2015, 日本胸部外科学会 優秀論文賞　　　　　　　　　　　　　　　
若狭哲

Dec. 2013, 第27回日本冠疾患学会学術集会, 最優秀演題　　　　　　　　　　　　　　　
若狭哲

Intermittent Mechanical Aortic Valve Sticking Due to Pannus Formation Complicated by Coronary Embolism and Cardiac Arrest.
Yu Agata, Atsushi Tada, Hiroshi Sugiki, Koji Sato, Rui Katano, Kenta Otsuka, Yutaro Yasui, Suguru Ishizaka, Toshiyuki Nagai, Satoru Wakasa, Toshihisa Anzai
The Canadian journal of cardiology, 14 Jan. 2026, [International Magazine]
English, Scientific journal

Diffusion-Weighted Whole-Body Magnetic Resonance Imaging with Background Body Signal Suppression for Differentiating Infectious from Non-Infectious Aortitis
Jien Saito, Masahiro Muto, Masafumi Tada, Isao Yokota, Shinji Kamiya, Yukihide Numata, Hideki Sasaki, Takuya Hashizume, Kenji Iwata, Miki Asano, Satoru Wakasa
Diagnostics, Jan. 2026
Scientific journal

Blood Flow Dynamics of Self-expanding vs Balloon-expandable Transcatheter Aortic Valve Replacement in Patients With a Small Aortic Annulus.
Takeshi Hamaya, Kiwamu Kamiya, Toshiyuki Nagai, Satonori Tsuneta, Noriko Oyama-Manabe, Hirokazu Komoriyama, Yuki Takahashi, Akinori Takahashi, Yuki Mori, Yoshifumi Mizuguchi, Sakae Takenaka, Suguru Ishizaka, Takuma Sato, Taro Temma, Yasushige Shingu, Kohsuke Kudo, Satoru Wakasa, Toshihisa Anzai
The Canadian journal of cardiology, 41, 12, 2364, 2377, Dec. 2025, [International Magazine]
English, Scientific journal, BACKGROUND: A recent trial showed the supra-annular self-expanding valve (SEV) provides superior valve function compared to the balloon-expandable valve (BEV) in patients with aortic stenosis (AS) and a small aortic annulus (SAA) undergoing transcatheter aortic valve replacement (TAVR). This study aimed to compare blood flow hemodynamics between SEV and BEV using four-dimensional flow cardiovascular magnetic resonance imaging (4D flow CMR). METHODS: We prospectively examined 166 consecutive patients with AS who underwent TAVR between May 2018 and March 2025. SAA was defined as an annular area ≤ 430 mm2. Patients were categorized into four groups: SAA-SEV (n = 35), SAA-BEV (n = 66), non-SAA-SEV (n = 21), and non-SAA-BEV (n = 44). Blood flow patterns, wall shear stress (WSS), and energy loss were assessed using 4D flow CMR. RESULTS: In patients with SAA, the SEV group showed significantly greater absolute reductions in vortical flow, helical flow, and flow eccentricity after TAVR compared to the BEV group (-0.47 ± 0.9 vs. 0.15 ± 1.0, P = 0.003; -0.79 ± 0.8 vs. -0.36 ± 0.9, P = 0.008; and -0.59 ± 0.9 vs. -0.20 ± 0.8, P = 0.024, respectively). The absolute reduction of average WSS was also significantly greater in the SEV group (-2.0 [-3.0 to -0.9] Pa vs. -0.9 [-2.5 to 0.4] Pa, P = 0.037). These differences were not observed in the non-SAA groups. CONCLUSIONS: In SAA patients undergoing TAVR, SEV demonstrated a significantly greater reduction in abnormal blood flow patterns and average WSS than BEV.

ハムスター心臓における冷却保存耐性 ミトコンドリア遺伝子発現解析　　　　　　　　　　　　　　　
コウ セイブン, 新宮 康栄, 杉木 宏司, 山口 良文, 若狭 哲
移植, 60, 297, 297, (一社)日本移植学会, Oct. 2025
Japanese

JCS/JHFS 2025 Guideline on Diagnosis and Treatment of Heart Failure.
Takeshi Kitai, Shun Kohsaka, Takao Kato, Eri Kato, Kimi Sato, Kanako Teramoto, Hidenori Yaku, Eiichi Akiyama, Masahiko Ando, Chisato Izumi, Tomomi Ide, Yu-Ki Iwasaki, Yohei Ohno, Takahiro Okumura, Neiko Ozasa, Shuichiro Kaji, Takeshi Kashimura, Hiroaki Kitaoka, Yoshiharu Kinugasa, Shintaro Kinugawa, Koichi Toda, Toshiyuki Nagai, Makiko Nakamura, Shungo Hikoso, Masatoshi Minamisawa, Satoru Wakasa, Yuta Anchi, Shogo Oishi, Akiko Okada, Masaru Obokata, Nobuyuki Kagiyama, Naoko P Kato, Takashi Kohno, Takuma Sato, Yasuyuki Shiraishi, Yodo Tamaki, Yuichi Tamura, Kazuya Nagao, Yuji Nagatomo, Naoko Nakamura, Kotaro Nochioka, Akihiro Nomura, Seitaro Nomura, Yu Horiuchi, Atsushi Mizuno, Ryosuke Murai, Takayuki Inomata, Koichiro Kuwahara, Yasushi Sakata, Hiroyuki Tsutsui, Koichiro Kinugawa
Journal of cardiac failure, 01 Sep. 2025, [International Magazine]
English

Aneurysm shape and sac shrinkage after total arch replacement with frozen elephant trunk for true aortic arch aneurysm.
Shinji Abe, Yasushige Shingu, Taro Minamida, Nobuyasu Kato, Hiroshi Sugiki, Satoru Wakasa
Interdisciplinary cardiovascular and thoracic surgery, 40, 9, 21 Aug. 2025, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
English, Scientific journal, OBJECTIVES: This study aimed to evaluate midterm outcomes and identify predictors of sac shrinkage following total arch replacement with a frozen elephant trunk (TAR-FET) for true aortic arch aneurysms. METHODS: A retrospective analysis was conducted on 28 patients who underwent elective TAR-FET for true arch aneurysms between July 2014 and March 2022. Postoperative sac changes on CT were categorized as shrinkage (≥5 mm reduction), enlargement (≥5 mm increase), or no change (<5 mm change). The sphericity index, a novel morphological parameter, was calculated by dividing the average axial and sagittal sac diameters by sac length. RESULTS: The median age was 74 years, and 23 were male. No operative deaths or recurrent laryngeal nerve palsy occurred. Among 28 patients, 12 experienced sac shrinkage attributable to the initial TAR-FET. Over a median follow-up of 3.6 years, 12 cases showed shrinkage, 2 enlargement, and 14 no change. Cumulative shrinkage rates at 1, 2, and 3 years were 42%, 47%, and 47%, respectively. Additional TEVAR was required in 5 patients (22% at 3 years). Multivariable analysis showed that shorter preoperative sac length (subdistribution hazard ratio 0.96; 95% CI, 0.93-0.99) and a higher sphericity index (per 0.1 increment: subdistribution hazard ratio 1.38; 95% CI, 1.21-1.57) were independently associated with sac shrinkage. CONCLUSIONS: TAR-FET resulted in sac shrinkage in a substantial proportion of patients. Aneurysms that were shorter and more protruding, as indicated by a higher sphericity index, may be more likely to exhibit postoperative sac shrinkage.

[Left Ventriculoplasty for Ventricular Septal Rupture and Left Ventricular Aneurysm Following Acute Myocardial Infarction:Report of a Case].
Yoshinobu Watabe, Koji Sato, Taiki Ito, Satoru Wakasa
Kyobu geka. The Japanese journal of thoracic surgery, 78, 6, 449, 453, Jun. 2025, [Last author, Corresponding author], [Domestic magazines]
Japanese, A 70-year-old man with acute myocardial infarction underwent percutaneous coronary intervention (PCI) for the diagonal branch. Eight days after PCI, the patient presented worsening heart failure. Transthoracic echocardiography( TTE) and enhanced computed tomography( CT) revealed ventricular septal rupture( VSR) and left ventricular aneurysm( LVA). After establishing cardiopulmonary bypass, the LVA was longitudinally excised along the left anterior descending artery( LAD). A septal anterior ventricular exclusion( SAVE) procedure was performed using a bovine pericardial patch to exclude the LVA and VSR. The VSR was directly closed with pledgeted sutures. Additionally, coronary artery bypass grafting was performed to the LAD using the left internal thoracic artery. The patient was discharged without any complications.

Impact of right ventricular reserve function during exercise on aortic valve opening in patients with left ventricular assist device.
Sakae Takenaka, Takuma Sato, Toshiyuki Nagai, Atsushi Tada, Yuta Kobayashi, Sho Kazui, Yutaro Yasui, Takeshi Hamaya, Yuki Mori, Akinori Takahashi, Suguru Ishizaka, Takao Konishi, Taro Temma, Kiwamu Kamiya, Tomonori Ooka, Satoru Wakasa, Toshihisa Anzai
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 44, 11, 1776, 1785, 31 May 2025, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Although aortic valve (AV) opening during exercise has fewer adverse events in patients with a left ventricular (LV) assist device (LVAD), factors associated with it remain unclear. We hypothesized that right ventricular (RV) reserve function is associated with the AV opening status. This study aimed to explore the hemodynamic parameters observed at rest and during maximal exercise and investigate the association between the RV reserve function and AV opening status in patients with an LVAD. METHODS: We prospectively examined 25 consecutive patients with an LVAD who underwent invasive exercise right heart catheterization with simultaneous echocardiography in the supine position. The AV opening status was assessed at rest and during exercise. The change in RV stroke work index (RVSWI) from rest to peak exercise (ΔRVSWI) was calculated to assess the RV reserve function. Patients were divided into three groups according to AV opening: AV opening both at rest and during exercise (n = 7), AV opening during exercise only (n = 8), and closed AV (n = 10). RESULTS: Patients with a closed AV had significantly lower ΔRVSWI and ΔRV dP/dt max than those with AV opening both at rest and during exercise and AV opening during exercise only, whereas changes in pulmonary artery wedge pressure and pulmonary vascular resistance were comparable across the groups. In a multivariable logistic regression analysis, ΔRVSWI was independently associated with AV opening even after adjustment for the change in LV ejection fraction from rest to peak exercise. During a median follow-up period of 743 (interquartile range, 483-1037) days, the incidence of adverse events was higher in patients in the closed AV group than in those in the AV opening groups (p = 0.002). CONCLUSIONS: RV reserve function is associated with AV opening status in patients with an LVAD. CLINICAL TRIAL REGISTRATION: URL: https://www.umin.ac.jp/ctr/index.htm. Unique Identifier: UMIN000039001.

Effects of Left Ventricular Unloading on Cardiac Function, Heart Failure Markers, and Autophagy in Rat Hearts with Acute Myocardial Infarction
Ryota Azuma, Yasushige Shingu, Jingwen Gao, Satoru Wakasa
International Journal of Molecular Sciences, 26, 9, 06 May 2025, [Peer-reviewed], [Last author], [International Magazine]
English, Scientific journal, Percutaneous ventricular assist devices are utilized in cases of cardiogenic shock following acute myocardial infarction (AMI). However, the mechanism underlying the beneficial effects of LV unloading in AMI remains unclear. This study aimed to examine the impact of LV unloading on cardiac function, heart failure markers, and protein degradation (autophagy and ubiquitin-proteasome system: UPS) post AMI in rats. Nine-week-old male Lewis rats were randomized into non-AMI, AMI, non-AMI with LV unloading, and AMI with LV unloading groups. LV unloading was achieved through heterotopic heart-lung transplantation. Rats were euthanized 2 and 14 days after the procedure. Cardiac functional assessment was performed using Langendorff heart perfusion. RT-PCR and Western blot analyses were conducted using the LV myocardium. The rate pressure product was comparable between the non-AMI with LV unloading group and the AMI with LV unloading at 14 days. The atrial natriuretic factor tended to be suppressed by LV unloading. LV unloading had reducing effects on the expressions of p62, selectively degraded during autophagy, both 2 and 14 days after AMI. There was no effect on the parameters for the UPS. LV unloading has a mitigating effect on the deterioration of cardiac function following AMI. Autophagy, which was suppressed by AMI, was ameliorated by LV unloading.

[How to Avoid Reoperation for Complications Associated with Durable Mechanical Circulatory Support Therapy].
Tomonori Ooka, Taro Minamida, Hiroshi Sugiki, Yasushige Shingu, Satoru Wakasa
Kyobu geka. The Japanese journal of thoracic surgery, 78, 4, 318, 323, Apr. 2025, [Domestic magazines]
Japanese, Since April 2011, durable mechanical circulatory support (DMCS) has been used for bridge to transplant (BTT-DMCS) in Japan, with its success leading to insurance coverage for destination therapy (DT-DMCS) in 2021. Despite advancements, managing DMCS-related complications remains challenging, with high readmission rates impacting patients' quality of life and healthcare facilities' workloads. Key complications include de novo aortic insufficiency (dnAI), driveline infections (DLI), and external outflow graft obstruction( EOGO). dnAI contributes significantly to chronic right heart failure, with no consensus on optimal intervention timing. Techniques such as bioprosthetic aortic valve replacement (bioAVR) and central aortic valve closure( CAVC) are employed, each with distinct benefits and limitations. DLI, often caused by mechicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant bacteria, or Mycobacterium abscessus, necessitates advanced wound management, driveline translocation, and prolonged antibiotic therapy. Imaging modalities like 18-FDG PET/CT are crucial for accurate diagnosis and treatment planning. EOGO, frequently caused by seroma compression, can lead to circulatory failure and often requires surgical intervention or catheter-based treatments. Preventing reoperations, optimizing intervention timing, and ensuring multidisciplinary collaboration are essential strategies for improving patient outcomes and enhancing the long-term effectiveness of DMCS therapy.

A Case of Chronic Expanding Hematoma Presenting as a Subcutaneous Mass 24 Years after Konno Procedure
Yoshinobu Watabe, Koji Sato, Taiki Ito, Satoru Wakasa
Surgical Case Reports, 11, 1, 2025, [Domestic magazines]
English, Scientific journal, INTRODUCTION: Here, we report a very rare case of chronic expanding hematoma presenting as a gradually enlarging subcutaneous pulsatile mass detected 24 years after a Konno procedure. CASE PRESENTATION: A 37-year-old man, who had undergone a Konno procedure at the age of 13 for severe aortic stenosis caused by a bicuspid aortic valve, presented with a pulsatile subcutaneous mass that had gradually increased in size over a 4-month period. CT revealed a large mediastinal mass compressing the right ventricular outflow tract, and a transthoracic echocardiogram showed an elevated pressure gradient between the right ventricle and pulmonary artery. Surgical resection of the mass and reconstruction of the right ventricular outflow tract were performed. The mass was completely excised, and the outflow tract was reconstructed using a short valved composite graft. The patient had an uneventful postoperative course. CONCLUSIONS: This case underscores the importance of considering chronic expanding hematoma in the differential diagnosis of new pulsatile masses in patients with a history of cardiac surgery and demonstrates that timely surgical intervention can be performed safely and effectively.

CORRIGENDUM: JCS/JHFS 2025 Guideline on Diagnosis and Treatment of Heart Failure.
Takeshi Kitai, Shun Kohsaka, Takao Kato, Eri Kato, Kimi Sato, Kanako Teramoto, Hidenori Yaku, Eiichi Akiyama, Masahiko Ando, Chisato Izumi, Tomomi Ide, Yu-Ki Iwasaki, Yohei Ohno, Takahiro Okumura, Neiko Ozasa, Shuichiro Kaji, Takeshi Kashimura, Hiroaki Kitaoka, Yoshiharu Kinugasa, Shintaro Kinugawa, Koichi Toda, Toshiyuki Nagai, Makiko Nakamura, Shungo Hikoso, Masatoshi Minamisawa, Satoru Wakasa, Yuta Anchi, Shogo Oishi, Akiko Okada, Masaru Obokata, Nobuyuki Kagiyama, Naoko P Kato, Takashi Kohno, Takuma Sato, Yasuyuki Shiraishi, Yodo Tamaki, Yuichi Tamura, Kazuya Nagao, Yuji Nagatomo, Naoko Nakamura, Kotaro Nochioka, Akihiro Nomura, Seitaro Nomura, Yu Horiuchi, Atsushi Mizuno, Ryosuke Murai, Takayuki Inomata, Koichiro Kuwahara, Yasushi Sakata, Hiroyuki Tsutsui, Koichiro Kinugawa
Circulation journal : official journal of the Japanese Circulation Society, 89, 9, 1579, 1581, 2025, [Domestic magazines]
English, Scientific journal

Usefulness of the Slope of the Preload Recruitable Stroke Work Relationship for the Prediction of Rehospitalization After Transcatheter Mitral Edge-to-Edge Repair.
Yasushige Shingu, Jien Saito, Kiwamu Kamiya, Toshiyuki Nagai, Toshihisa Anzai, Satoru Wakasa
Circulation journal : official journal of the Japanese Circulation Society, 89, 1, 139, 144, 25 Dec. 2024, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, BACKGROUND: Among patients with functional mitral regurgitation (FMR), responders to transcatheter mitral edge-to-edge repair (TEER) remain unclear. We investigated whether the slope of the preload recruitable stroke work relationship (Mw; calculated as stroke work / [EDV - k × EDV + {1 - k} × LV wall], where EDV is end-diastolic volume, k is a constant, and LV wall is the volume of the left ventricular wall) could predict rehospitalization in FMR patients after TEER. METHODS AND RESULTS: Mwwas calculated for 24 FMR patients using echocardiography. The median left ventricular ejection fraction was 27% and the median Mwwas 32. Over a 498-day median follow-up period, 38% of patients were rehospitalized for heart failure, and only Mwhad a high area under the curve in time-dependent receiver operating characteristic analysis. CONCLUSIONS: Mwis an effective predictor for rehospitalization in FMR patients after TEER.

A Protocol Investigation Comparing Transcatheter Repair with the Standard Surgical Procedure for Secondary Mitral Regurgitation
Francesco Nappi, Sanjeet Singh Avtaar Singh, Antonio Salsano, Aubin Nassif, Yasushige Shingu, Satoru Wakasa, Antonio Fiore, Cristiano Spadaccio, Zein EL-Dean
Journal of Clinical Medicine, 13, 24, 18 Dec. 2024, [International Magazine]
English, Scientific journal, Background: Secondary mitral regurgitation (SMR) is characterized by a pathological process impacting the left ventricle (LV) as opposed to the mitral valve (MV). In the absence of structural alterations to the MV, the expansion of the LV or impairment of the papillary muscles (PMs) may ensue. A number of technical procedures are accessible for the purpose of determining the optimal resolution for MR. Nevertheless, there is a dearth of rigorous data to facilitate a comparative analysis of MV replacement, MV repair (including subvalvular repair), and transcatheter mitral valve interventions (TMV-Is). The objective of this investigation is to evaluate and compare the efficacy and clinical outcomes of transcatheter mitral valve repair (TMV-r) utilizing the edge-to-edge mitral valve repair (TEER) procedure in comparison to conventional surgical mitral valve interventions (S-SMVis) in patients with secondary mitral regurgitation. Methods and analysis: A consortium of five cardiac surgery institutions from four European states and Japan have joined forces to establish a multicenter observational registry, designated TEERMISO. Patients who underwent technical procedures for SMR between January 2007 and December 2023 will be enrolled consecutively into the TEERMISO registry. The investigation team evaluated the comparative efficacy of replacement and repair techniques, utilizing both the standard surgical methodology and the transcatheter intervention. The primary clinical outcome will be the degree of left ventricular remodeling, as assessed by the left ventricular end-diastolic volume index, at 10 years. The forthcoming research will assess a variety of secondary endpoints, among which all-cause mortality will be the primary endpoint. Subsequent assessments will be made in the following order: functional status, hospitalization, neurocognition, physiological measures (echocardiographic assessment), occurrence of adverse clinical incidents, and reoperation. Ethics and dissemination: The multicenter design of the database is anticipated to reduce the potential for bias associated with institutional caseload and surgical experience. All participating centers possess an established mitral valve protocol that facilitates comprehensive follow-up and management of any delayed mitral complications following replacement surgery or surgical repair of the secondary mitral regurgitation. The data collected will provide insights into the impact of diverse surgical approaches on standard mitral valve surgery and TEER. This will facilitate the evaluation of LV remodeling over the course of long-term post-procedural follow-up. Trial Registration: ClinicalTrials.gov ID: NCT05090540; IRB ID: 202201143.

Associations of sarcopenia and malnutrition with 30-day in-hospital morbidity and mortality after cardiac surgery.
Takahiro Abe, Tasuku Inao, Yasushige Shingu, Akira Yamada, Shingo Takada, Arata Fukushima, Noriko Oyama-Manabe, Isao Yokota, Satoru Wakasa, Shintaro Kinugawa, Takashi Yokota
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 67, 1, 17 Dec. 2024, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: Sarcopenia and malnutrition often occur simultaneously in adults with cardiovascular diseases. Our objective was to determine the associations of preoperative sarcopenia and malnutrition with major adverse cardiac and cerebral events (MACCE) after cardiac surgery. METHODS: We retrospectively analyzed 154 consecutive patients who underwent elective cardiac surgery between January 2015 and June 2018 at two institutions in Japan. Sarcopenia and nutritional status were preoperatively assessed by bilateral psoas muscle volume index (PMVI) using CT scans and the prognostic nutritional index (PNI), respectively. RESULTS: The median age in the total cohort was 69 years, and 43% were women. Within 30 days after surgery, 20 patients developed in-hospital MACCE and 7 patients died of any cause. Low PMVI (<72.25 cm3/m2) and low PNI (<48.15) were each independent predictors of postoperative MACCE occurrence with odds ratios (95% confidence interval) of 3.58 (1.22-10.53) and 3.73 (1.25-11.09) when adjusted for age and sex, and 3.25 (1.07-9.87) and 3.27 (1.08-9.89) when adjusted for preoperative left ventricular ejection fraction, angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker, and anticoagulant. In addition, the combination of low PMVI and low PNI conferred the highest risk of in-hospital MACCE among the 4 groups (ie, the low PMVI, low PNI, low PMVI+low PNI, and neither low PMVI nor low PNI groups). CONCLUSIONS: Preoperative low PMVI and low PNI were respectively associated with 30-day in-hospital MACCE occurrence after cardiac surgery. Notably, coexistence of these reductions further enhanced the risk of postoperative MACCE.

A study protocol for an international registry observational study evaluating clinical outcomes of transcatheter versus standard surgical mitral valve operation for secondary mitral regurgitation: the TEERMISO study
Francesco Nappi, Sanjeet Singh Avtaar Singh, Antonio Salsano, Cristiano Spadaccio, Yasushige Shingu, Satoru Wakasa, Antonio Fiore
BMJ open, 15, 1, e086888, 02 Nov. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: Secondary mitral regurgitation (SMR) is a condition affecting the left ventricle (LV) rather than the mitral valve (MV). If the MV remains structurally unchanged, enlargement of the LV or impairment of the papillary muscles can occur. Several mechanical interventions are available to dictate the resolution of MR. However, there is a lack of robust data to compare MV replacement, MV repair (including subvalvular repair) and transcatheter mitral valve procedures (TMVp). This study aims to compare the effectiveness and clinical outcomes of TMVp using the edge-to-edge mitral valve repair technique and standard surgical mitral valve procedures in patients with SMR. METHODS AND ANALYSIS: Five cardiac surgery centres from four European countries and Japan have collaborated to create a multicentre observational registry (TEERMISO). The registry will enrol consecutive patients who underwent mechanical intervention for SMR between January 2007 and December 2023. The investigators assessed the difference between replacement and repair for both the standard surgical approach and the transcatheter procedure. The main clinical outcome will be the degree of LV remodelling as assessed by the Left Ventricular End-Diastolic Volume Index at 10 years. The study will measure several secondary endpoints, including all-cause mortality as the primary endpoint, followed by functional status, hospitalisation, neurocognition, physiological measures (echocardiographic assessment), adverse events and reoperation. ETHICS AND DISSEMINATION: Ethics approval was obtained in Montpellier University Hospital on 24 May 2022 (Institutional Review Board Approval Number: IRB-MTP_2022_05_202201143). The results of the main study and each sub-analysis will be submitted for publication in a peer-reviewed journal. TRIAL REGISTRATION NUMBER: NCT05090540.

L-Carnitine: A New Therapeutic Option for the Prevention of Atrial Fibrillation in Non-Cardiac Surgery—A Single-Group Interventional Pilot Study
Yasushige Shingu, Isao Yokota, Tatsuya Kato, Yasuhiro Hida, Kichizo Kaga, Jingwen Gao, Satoru Wakasa
Journal of Clinical Medicine, 13, 20, 18 Oct. 2024, [Peer-reviewed], [International Magazine]
English, Scientific journal, Background: L-carnitine is essential in lipid metabolism and reportedly has preventive effects for arrhythmia. Our objective was to examine the incidence of postoperative atrial fibrillation (POAF) and changes in serum biomarker levels following perioperative L-carnitine administration in patients with lung cancer. Methods: Thirteen patients undergoing a lobectomy with preoperative serum brain natriuretic peptide levels >24 pg/mL were perioperatively administered L-carnitine for 5 days (3 g/3×). Accurate 95% confidence intervals (CI) for POAF incidence were calculated. Serum biomarkers for POAF in lung cancer and target proteins for L-carnitine were evaluated by using open-source data from proteomic analysis. Results: The incidence of POAF was 38.5% (95% CI 13.9%-68.4%). Fatty acid-binding protein 4 (FABP4) was selected as a candidate biomarker from 1472, 63, and 26 proteins related to lung cancer, L-carnitine, and AF, respectively. A positive correlation was observed between the predicted POAF incidence rate and preoperative FABP4 levels (Pearson's r = 0.5183). The mean change in serum FABP4 after L-carnitine administration for 5 days was -2.9 ng/mL (95% CI -4.9 to -0.89 ng/mL). Conclusions: The incidence of POAF after a lobectomy was 38.5% after the perioperative administration of L-carnitine for patients at a high risk of POAF. The serum FABP4 level demonstrates potential as a candidate biomarker for POAF prediction.

Distinct Roles of Omental and Latissimus Dorsi Flaps for Blocking Infection Pathways and Protecting A Left Ventricular Assist Device
Dongkyung Seo, Taku Maeda, Tomonori Ooka, Takahiro Miura, Kosuke Ishikawa, Emi Funayama, Satoru Wakasa, Yuhei Yamamoto
The Heart Surgery Forum, 27, 9, E998, E1002, Forum Multimedia Publishing LLC, 10 Sep. 2024, [Peer-reviewed]
Scientific journal, Left ventricular assist devices (LVADs) are vital for managing severe heart failure in transplant-ineligible patients, but device exposure and infection pose significant challenges. This report details a 42-year-old man with dilated cardiomyopathy and bronchial asthma who presented with an externalized LVAD following a HeartMate II to HeartMate III exchange due to malfunction. Our tailored surgical strategy treated the LVAD driveline and main body as two distinct parts. This distinction is crucial, as major upstream infections typically originate from the driveline. We applied flaps to these parts for different purposes, maximizing their unique characteristics. The omental flap, chosen for its flexibility, blood supply, and immunological activation upon foreign body contact, covered the driveline. The latissimus dorsi flap provided vascularity and mechanical protection for the LVAD. Additionally, we review the omentum's basic physiological aspects, which are often unfamiliar to clinicians. Infection has not recurred in 6 months postoperatively, demonstrating the approach's effectiveness.

Orthotopic heart transplantation in patient with situs inversus and pectus excavatum: a case report.
Satoru Wakasa, Tomonori Ooka, Takuma Sato, Yasushige Shingu, Nobuyasu Kato, Toshiyuki Nagai, Toshihisa Anzai, Minoru Ono, Yoshiro Matsui
Surgical case reports, 10, 1, 202, 202, 30 Aug. 2024, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
English, Scientific journal, BACKGROUND: Heart transplantation in patients with situs inversus is challenging, especially in terms of reconstruction of the systemic venous return. Several rerouting techniques have been presented but are associated with vulnerability to external compression, which might cause hemodynamic instability, especially in the presence of chest deformity. In this study, we report a rare case of successful heart transplantation in the presence of situs inversus and pectus excavatum. CASE PRESENTATION: A 55-year-old man, with a history of surgeries for corrected transposition of the great arteries with ventricular septal defect, was registered for heart transplantation owing to progression of heart failure. Subsequently, he had undergone a left ventricular assist device implantation; 14 years after registration, he underwent transplantation of the heart with normal anatomy. The inferior vena cava was reconstructed by anastomosing the left atria with a counterclockwise rotation of the donor heart and by lengthening the recipient inferior vena cava with a conduit made of the residual right atrial tissue. The superior vena cava was reconstructed using a donor innominate vein harvested with sufficient length. After successful weaning from cardiopulmonary bypass, the chest could not be closed because the heart was compressed owing to chest deformity, resulting in hemodynamic instability. Therefore, to exclude the left lung, a left pericardial screen was created using a bovine pericardium, allowing the chest to be closed with acceptable hemodynamics. The patient suffered postoperatively from a higher venous pressure, suggesting an obstruction of venous return early after surgery. The obstruction gradually resolved, and the patient was transferred for rehabilitation. CONCLUSIONS: Heart transplantation in the presence of situs inversus is challenging; moreover, the presence of pectus excavatum further complicates the procedure. The paradoxically larger left lung and chest deformity compressed and impaired reconstructed systemic venous return. Although intrathoracic exclusion of the left lung was effective, an intraoperative or early postoperative thoracoplasty for pectus excavatum was also a viable option. Patient-specific management is mandatory, depending on the anatomy.

Incidence of atrial fibrillation after esophageal cancer surgery with L-carnitine use: a preliminary single-group interventional study.
Yasushige Shingu, Isao Yokota, Toshiaki Shichinohe, Soichi Murakami, Yuma Ebihara, Yo Kurashima, Satoshi Hirano, Satoru Wakasa
Surgery today, 54, 8, 892, 898, Aug. 2024, [Peer-reviewed], [Last author], [Domestic magazines]
English, Scientific journal, PURPOSE: We aimed to investigate the POAF rate and blood FABP4 levels after perioperative L-carnitine administration in patients with esophageal cancer. METHODS: L-carnitine (3 g in three divided doses) was administered to 15 patients 2 days before and 3 days after surgery. POAF during the study period and blood FABP4 levels (ELISA) before and after L-carnitine administration were evaluated. Accurate 95% confidence intervals (CI) for POAF incidence and changes in blood FABP4 levels were calculated. The preoperative predicted POAF rate was calculated using an application for esophageal cancer. The correlation between FABP4 levels and the predicted POAF rate was analyzed using Pearson's coefficient (r). RESULTS: Thirteen patients completed this study. The predicted POAF rate was 24% (17%, 34%) (median; interquartile range). The actual incidence of POAF was 7.7% (95% CI: 0.2-36%). Blood FABP4 levels changed from 10.3 to 7.0 ng/mL; the average change was - 3.3 (95% CI: - 6.6 to - 0.1). A positive correlation was found between preoperative FABP4 levels and the predicted POAF rates (r = 0.564). CONCLUSIONS: The POAF rate after esophageal surgery was 7.7% for L-carnitine. L-carnitine may reduce blood FABP4 levels. This preliminary study will contribute to the planning of sample sizes in future randomized trials.

Chronic Active Myocarditis After Transapical Transcatheter Aortic Valve Implantation.
Yuta Kobayashi, Toshiyuki Nagai, Kiwamu Kamiya, Satonori Tsuneta, Yasushige Shingu, Kento Wakabayashi, Kohsuke Kudo, Yoshihiro Matsuno, Satoru Wakasa, Toshihisa Anzai
Circulation journal : official journal of the Japanese Circulation Society, 88, 6, 1008, 1008, 24 May 2024, [Peer-reviewed], [Domestic magazines]
English, Scientific journal

Effects of Trehalose Preconditioning on H9C2 Cell Viability and Autophagy Activation in a Model of Donation after Circulatory Death for Heart Transplantation.
Jingwen Gao, Yasushige Shingu, Satoru Wakasa
Current issues in molecular biology, 46, 4, 3353, 3363, 12 Apr. 2024, [Peer-reviewed], [Last author], [International Magazine]
English, Scientific journal, Donation after circulatory death (DCD) is a promising strategy for alleviating donor shortage in heart transplantation. Trehalose, an autophagy inducer, has been shown to be cardioprotective in an ischemia-reperfusion (IR) model; however, its role in IR injury in DCD remains unknown. In the present study, we evaluated the effects of trehalose on cardiomyocyte viability and autophagy activation in a DCD model. In the DCD model, cardiomyocytes (H9C2) were exposed to 1 h warm ischemia, 1 h cold ischemia, and 1 h reperfusion. Trehalose was administered before cold ischemia (preconditioning), during cold ischemia, or during reperfusion. Cell viability was measured using the Cell Counting Kit-8 after treatment with trehalose. Autophagy activation was evaluated by measuring autophagy flux using an autophagy inhibitor, chloroquine, and microtubule-associated protein 1A/1B light chain 3 B (LC3)-II by western blotting. Trehalose administered before the ischemic period (trehalose preconditioning) increased cell viability. The protective effects of trehalose preconditioning on cell viability were negated by chloroquine treatment. Furthermore, trehalose preconditioning increased autophagy flux. Trehalose preconditioning increased cardiomyocyte viability through the activation of autophagy in a DCD model, which could be a promising strategy for the prevention of cardiomyocyte damage in DCD transplantation.

Influence of epicardial adipose tissue inflammation and adipocyte size on postoperative atrial fibrillation in patients after cardiovascular surgery
Hiroyuki Natsui, Masaya Watanabe, Takashi Yokota, Satonori Tsuneta, Yoshizuki Fumoto, Haruka Handa, Matsushima Shouji, Jiro Koya, Kotaro Nishino, Daishiro Tatsuta, Takuya Koizumi, Takahide Kadosaka, Motoki Nakao, Taro Koya, Taro Temma, Yoichi M. Ito, Hatanaka C. Kanako, Yutaka Hatanaka, Shingu Yasushige, Satoru Wakasa, Shuhei Miura, Takahiko Masuda, Naritomo Nishioka, Shuichi Naraoka, Kayoko Ochi, Tomoko Kudo, Tsugumine Ishikawa, Toshihisa Anzai
Physiological Reports, 12, 6, e15957, Wiley, 28 Mar. 2024, [Peer-reviewed], [International Magazine]
English, Scientific journal, Abstract

Epicardial adipose tissue (EAT) is an active endocrine organ that is closely associated with occurrence of atrial fibrillation (AF). However, the role of EAT in the development of postoperative AF (POAF) remains unclear. We aimed to investigate the association between EAT profile and POAF occurrence in patients who underwent cardiovascular surgery. We obtained EAT samples from 53 patients to evaluate gene expression, histological changes, mitochondrial oxidative phosphorylation (OXPHOS) capacity in the EAT, and protein secretion in EAT‐conditioned medium. EAT volume was measured using computed tomography scan. Eighteen patients (34%) experienced POAF within 7 days after surgery. Although no significant difference was observed in EAT profile between patients with and without POAF, logistic regression analysis identified that the mRNA expression levels of tumor necrosis factor‐alpha (TNF‐α) were positively correlated and adipocyte size in the EAT was inversely correlated with onset of POAF, respectively. Mitochondrial OXPHOS capacity in the EAT was not associated with POAF occurrence; however, it showed an inverse correlation with adipocyte size and a positive correlation with adiponectin secretion. In conclusion, changes in the secretory profile and adipocyte morphology of the EAT, which represent qualitative aspects of the adipose tissue, were present before the onset of AF.

Interpapillary muscle distance independently predicts recurrent mitral regurgitation.
Ivancarmine Gambardella, Cristiano Spadaccio, Sanjeet S A Singh, Yasushige Shingu, Takashi Kunihara, Satoru Wakasa, Francesco Nappi
Journal of cardiothoracic surgery, 19, 1, 147, 147, 20 Mar. 2024, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: Ischaemic secondary mitral regurgitation (ISMR) after surgery is due to the displacement of papillary muscles resulting from progressive enlargement of the left ventricle end-diastolic diameter (LVEDD). Our aim was to prove that if the interpapillary muscle distance (IPMD) is surgically stabilized, an increase in LVEDD will not lead to a recurrence of ischaemic mitral regurgitation (MR). METHODS: Ninety-six patients with ISMR, who underwent surgical revascularisation and annuloplasty, were randomly assigned in a 1:1 ratio to undergo papillary muscle approximation (PMA). At the 5-year follow-up, we assessed the correlation between PMA and echocardiographic improvements, the effect size of PMA on echocardiographic improvements, and a prediction model for recurrent MR using inferential tree analysis. RESULTS: There was a significant correlation between PMA and enhancements in both the α and β angles (Spearman's rho > 0.7, p < 0.01). The α angle represents the angle between the annular plane and either the A2 annular-coaptation line or the P2 annular-coaptation line. The β angle indicates the angle between the annular plane and either the A2 annular-leaflet tip line or the P2 annular-leaflet tip line. PMA led to substantial improvements in LVEDD, tenting area, α and β angles, with a large effect size (Hedge's g ≥ 8, 95% CI ORs ≠ 1). The most reliable predictor of recurrent MR grade was the interpapillary distance, as only patients with an interpapillary distance greater than 40 mm developed ≥ 3 + grade MR. For patients with an IPMD of 40 mm or less, the best predictor of recurrent MR grade was LVEDD. Among the patients, only those with LVEDD greater than 62 mm showed moderate (2+) MR, while only those with LVEDD less than or equal to 62 mm had absent to mild (1+) MR. CONCLUSION: Prediction of recurrent ischaemic MR is not independent of progressive LVEDD increase. PMA-based surgical procedure stabilises IPMD.

EVAR後のopen conversion surgery ステントグラフト温存瘤縫縮術予後の検討　　　　　　　　　　　　　　　
佐藤 公治, 伊藤 大貴, 若狭 哲
日本心臓血管外科学会学術総会抄録集, 54回, WS15, 2, (NPO)日本心臓血管外科学会, Feb. 2024
English

当院におけるFROZENIXを用いたTAR-OSG後のDSINE発生症例についての検討　　　　　　　　　　　　　　　
渡部 克将, 佐藤 公治, 若狭 哲
日本血管外科学会雑誌, 33, Suppl., P18, 8, (NPO)日本血管外科学会, 2024
Japanese

Posterior Papillary Muscle Suspension for Treating Systolic Anterior Motion in Hypertrophic Obstructive Cardiomyopathy.
Taiki Ito, Satoru Wakasa, Koji Sato, Shinji Abe, Taro Minamida
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 30, 1, 2024, [Peer-reviewed], [Corresponding author], [Domestic magazines]
English, Scientific journal, Systolic anterior motion of the anterior mitral leaflet can persist after ventricular septal myectomy for obstructive hypertrophic cardiomyopathy, resulting in residual pressure gradients and mitral regurgitation. However, additional procedures for systolic anterior motion involving mitral valve leaflet suturing and resection may lead to future valve disease. Therefore, we adopted posterior papillary muscle suspension, a subvalvular procedure for functional mitral regurgitation, to treat systolic anterior motion without directly intervening in the mitral valve leaflets. Papillary muscle suspension toward the posterior mitral annulus moved the papillary muscles away from the interventricular septum and successfully eliminated the systolic anterior motion and midventricular pressure gradient. In terms of avoiding direct mitral interventions, this procedure is a viable option for systolic anterior motion, especially in cases of very mild mitral regurgitation.

Rough-zone suspension with mitral valve replacement for ventricular functional mitral regurgitation.
Satoru Wakasa, Yasushige Shingu
General thoracic and cardiovascular surgery, 02 Nov. 2023, [Peer-reviewed], [Lead author, Corresponding author], [Domestic magazines]
English, Scientific journal, Chordal preservation is recommended in mitral valve replacement for functional mitral regurgitation to preserve left ventricular function. In contrast, papillary muscle suspension toward the anterior mitral annulus can induce left ventricular reverse remodeling after mitral valve replacement for functional mitral regurgitation. However, the extent of suspension depends on the surgeon's experience. Therefore, we developed a new concept of chordal preservation, called rough-zone suspension, which not only spares the subvalvular structure but also suspends the papillary muscles toward the annulus. This procedure is simple and reproducible for determining the extent of suspension, and can increase the probability of left ventricular reverse remodeling after mitral valve replacement for functional mitral regurgitation.

LMT病変に対するローターブレーター中の冠動脈穿孔、出血性ショックに対する一救命例　　　　　　　　　　　　　　　
渡部 克将, 伊藤 大貴, 佐藤 公治, 若狭 哲
日本冠疾患学会誌, Suppl.2023, 224, 224, (NPO)日本冠疾患学会, Nov. 2023
Japanese

Impact of sarcopenia on early and mid-term outcomes of surgery for acute type A aortic dissection in octogenarians.
Takahiro Ishigaki, Satoru Wakasa, Yasushige Shingu, Yohei Ohkawa, Akira Yamada
General thoracic and cardiovascular surgery, 71, 11, 674, 680, Nov. 2023, [Peer-reviewed], [Corresponding author], [Domestic magazines]
English, Scientific journal, OBJECTIVE: To determine the association between sarcopenia and surgical outcomes in octogenarians with acute type A aortic dissection. METHODS: We enrolled 72 octogenarians who had undergone type A aortic dissection surgery between April 2013 and March 2019. The psoas muscle index, an indexed area of the psoas muscle at the L3 level on preoperative computed tomography, was obtained as an indicator of sarcopenia. The study participants were divided into sarcopenia and non-sarcopenia groups based on the mean psoas muscle index. The postoperative outcomes were compared between the groups. RESULTS: The median age was 84 years (interquartile range 82-87 years), and 13 patients were male. The mean psoas muscle index was 3.53 ± 0.97 cm2/m2. Except for sex, no significant differences were observed in patients' baseline characteristics and operative data between the two groups. The 30-day mortality rates in the sarcopenia and non-sarcopenia groups were 14% and 8%, respectively (P = 0.71), and postoperative morbidity was similar in both groups. Postoperative all-cause mortality was significantly higher in the sarcopenia group (log-rank P = 0.038), especially in patients aged 85 years or older (log-rank P < 0.01). The sarcopenia group had a lower home discharge rate than the non-sarcopenia group (21% vs. 54%, P < 0.01), and home discharge was associated with longer survival (log-rank P = 0.015). CONCLUSIONS: All-cause mortality after emergency surgery for acute type A aortic dissection was significantly higher in octogenarians with sarcopenia than in those without, especially in patients aged 85 years or older.

Differences in blood flow dynamics between balloon- and self-expandable valves in patients with aortic stenosis undergoing transcatheter aortic valve replacement.
Yuki Takahashi, Kiwamu Kamiya, Toshiyuki Nagai, Satonori Tsuneta, Noriko Oyama-Manabe, Takeshi Hamaya, Sho Kazui, Yutaro Yasui, Kohei Saiin, Seiichiro Naito, Yoshifumi Mizuguchi, Sakae Takenaka, Atsushi Tada, Suguru Ishizaka, Yuta Kobayashi, Kazunori Omote, Takuma Sato, Yasushige Shingu, Kohsuke Kudo, Satoru Wakasa, Toshihisa Anzai
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 25, 1, 60, 60, 26 Oct. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: The differences in pre- and early post-procedural blood flow dynamics between the two major types of bioprosthetic valves, the balloon-expandable valve (BEV) and self-expandable valve (SEV), in patients with aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR), have not been investigated. We aimed to investigate the differences in blood flow dynamics between the BEV and SEV using four-dimensional flow cardiovascular magnetic resonance (4D flow CMR). METHODS: We prospectively examined 98 consecutive patients with severe AS who underwent TAVR between May 2018 and November 2021 (58 BEV and 40 SEV) after excluding those without CMR because of a contraindication, inadequate imaging from the analyses, or patients' refusal. CMR was performed in all participants before (median interval, 22 [interquartile range (IQR) 4-39] days) and after (median interval, 6 [IQR 3-6] days) TAVR. We compared the changes in blood flow patterns, wall shear stress (WSS), and energy loss (EL) in the ascending aorta (AAo) between the BEV and SEV using 4D flow CMR. RESULTS: The absolute reductions in helical flow and flow eccentricity were significantly higher in the SEV group compared in the BEV group after TAVR (BEV: - 0.22 ± 0.86 vs. SEV: - 0.85 ± 0.80, P < 0.001 and BEV: - 0.11 ± 0.79 vs. SEV: - 0.50 ± 0.88, P = 0.037, respectively); there were no significant differences in vortical flow between the groups. The absolute reduction of average WSS was significantly higher in the SEV group compared to the BEV group after TAVR (BEV: - 0.6 [- 2.1 to 0.5] Pa vs. SEV: - 1.8 [- 3.5 to - 0.8] Pa, P = 0.006). The systolic EL in the AAo significantly decreased after TAVR in both the groups, while the absolute reduction was comparable between the groups. CONCLUSIONS: Helical flow, flow eccentricity, and average WSS in the AAo were significantly decreased after SEV implantation compared to BEV implantation, providing functional insights for valve selection in patients with AS undergoing TAVR. Our findings offer valuable insights into blood flow dynamics, aiding in the selection of valves for patients with AS undergoing TAVR. Further larger-scale studies are warranted to confirm the prognostic significance of hemodynamic changes in these patients.

Blood flow characteristics of the bilateral internal thoracic artery: implications of optimal graft configuration for coronary artery bypass grafting to maximize blood supply.
Takashi Kunihara, Yasushige Shingu, Satoru Wakasa, Hiroshi Sugiki, Yasuhiro Kamikubo, Norihiko Shiiya, Yoshiro Matsui
General thoracic and cardiovascular surgery, 71, 10, 552, 560, Oct. 2023, [Domestic magazines]
English, Scientific journal, PURPOSE: There is controversy regarding which internal thoracic artery (ITA) should be anastomosed to the left anterior descending artery (LAD). Here, we propose an optimal graft design based on measurement of blood flow in the ITA. METHODS: Sixty-one patients (53 men, median age 68 [62-75] years) undergoing first elective coronary artery bypass grafting were enrolled. Fifty-seven left ITAs (LITAs) and 28 right ITAs (RITAs) were harvested in either a semi-skeletonized manner using a harmonic scalpel covered with papaverine-soaked gauze (group-A, n = 45) or a fully skeletonized manner using electrocautery with intraluminal papaverine injection (group-B, n = 41). Free flow of 33 ITAs was measured after pharmacological dilatation and in situ ITA-LAD flow was measured in 59 patients by transit-time flowmetry. RESULTS: RITA and LITA free flow were 147.0 [87.8-213.0] mL/min and 108.0 [90.0-144.0] mL/min, respectively (P = 0.199). The group-B had significantly higher ITA free flow (135.0 [102.0-171.0] mL/min) than group-A (63.0 [36.0-96.0] mL/min, P = 0.009). In 13 patients with bilateral ITA harvesting, free flow of the RITA (138.0 [79.5-204.0] mL/min) was also significantly higher than the LITA (102.0 [81.0-138.0] mL/min, P = 0.046). There was no significant difference between RITA and LITA flow anastomosed to the LAD. The group-B had significantly higher ITA-LAD flow (56.5 [32.3-73.6] mL/min) than group-A (40.9 [20.1-53.7] mL/min, P = 0.023). CONCLUSION: RITA provides significantly higher free flow than LITA but similar blood flow to the LAD. Full skeletonization with intraluminal papaverine injection maximizes both free flow and ITA-LAD flow.

Reconstruction of right ventricular outflow tract with severe calcification: lantern procedure.
Takahiro Ishigaki, Satoru Wakasa, Koji Sato, Nobuyasu Kato, Yasuhiro Kamikubo
General thoracic and cardiovascular surgery, 24 Aug. 2023, [Peer-reviewed], [Corresponding author], [Domestic magazines]
English, Scientific journal, Right ventricular outflow tract reconstruction is repeatedly required after the Rastelli procedure. However, standard right ventricular outflow tract reconstruction using direct anastomosis on the posterior right ventricular outflow tract wall is unfeasible in cases with severe calcification. Herein, we present a novel technique called the "lantern procedure," which can fix the prosthetic pulmonary valve without anastomosis to the calcified right ventricular outflow tract wall.

Surgical repair of a residual lesion of mixed-type total anomalous pulmonary venous connection using a vertical vein as a free graft: a case report(タイトル和訳中)　　　　　　　　　　　　　　　
Watabe Yoshinobu, Kato Nobuyasu, Niwano Haruki, Shingu Yasushige, Ooka Tomonori, Kato Hiroki, Abe Shinji, Wakasa Satoru
General Thoracic and Cardiovascular Surgery Cases, 2, 1 of 5, 5 of 5, BioMed Central, Aug. 2023, [Peer-reviewed]
English

当科における冠動脈に対する外科介入　　　　　　　　　　　　　　　
加藤 伸康, 阿部 慎司, 新宮 康栄, 大岡 智学, 加藤 裕貴, 山澤 弘州, 武田 充人, 若狭 哲
日本小児循環器学会総会・学術集会抄録集, 59回, [II, 03], (NPO)日本小児循環器学会, Jul. 2023
Japanese

Staged definitive repair for pulmonary atresia and ventricular septal defect 40 years after palliative surgery: a case report
Noriyoshi Ebuoka, Norihiro Ando, Hidetsugu Asai, Nobuyasu Kato, Tsuyoshi Tachibana, Satoru Wakasa
General Thoracic and Cardiovascular Surgery Cases, 05 Jun. 2023, [Peer-reviewed]
Scientific journal

Impact of Steroid on Macrophage Migration Inhibitory Factor During and After Cardiopulmonary Bypass.
Takashi Kunihara, Yasushige Shingu, Satoru Wakasa, Norihiko Shiiya, Satoshi Gando
ASAIO journal (American Society for Artificial Internal Organs : 1992), 69, 4, 391, 395, 01 Apr. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine released in response to glucocorticoids, which counter-regulates the effects of glucocorticoids. This study was performed to determine the impact of steroids on the expression of MIF and other pro- and anti-inflammatory cytokines during and after cardiopulmonary bypass (CPB). Twenty adult patients (10 men, 64 ± 8 years old) who underwent elective cardiac surgery by CPB were given either 2000 mg (group-H, n = 10) or 500 mg of methylprednisolone (group-L, n = 10) during CPB. The serum concentrations of MIF, interleukin (IL)-1β, IL-8, IL-10, and tumor necrosis factor-alpha (TNF-α) were measured at eight time points until 36 hours after skin closure. The early postoperative course was uneventful for all patients. There were no significant differences in duration of operation, CPB, or aortic cross-clamping (AXC) between the two groups. MIF and IL-10 levels peaked just after the conclusion of CPB and decreased gradually thereafter. IL-1β, IL-8, and TNF-α were undetectable throughout the study period. There were no significant differences in MIF or IL-10 levels between the two groups. Peak levels of MIF in all patients were significantly correlated with the duration of CPB and AXC, whereas no such correlation was observed for IL-10. MIF or IL-10 levels were significantly elevated during and after CPB, but there were no differences between the two doses of steroid administration. Both steroid doses sufficiently suppressed proinflammatory cytokines. MIF better reflected the invasiveness of the operation than IL-10.

Multimodal Imaging of Constrictive Pericarditis Induced by Long-term Pergolide Treatment for Parkinson's Disease.
Hiroyuki Aoyagi, Shingo Tsujinaga, Yuki Takahashi, Seiichiro Naito, Takuma Sato, Takuya Otsuka, Yoji Tamaki, Ko Motoi, Suguru Ishizaka, Yasuyuki Chiba, Kiwamu Kamiya, Hiroyuki Iwano, Toshiyuki Nagai, Satoru Wakasa, Toshihisa Anzai
Internal medicine (Tokyo, Japan), 31 Mar. 2023, [Domestic magazines]
English, Scientific journal, We herein report the first case of constrictive pericarditis (CP) induced by long-term pergolide treatment for Parkinson's disease that was assessed using multimodal imaging in a 72-year-old patient with leg edema and dyspnea. The patient was correctly diagnosed with CP using multimodal imaging and successfully treated with pericardiectomy. The treatment history of Parkinson's disease and pathological findings of the removed pericardium suggested that long-term pergolide was the cause of CP. Properly recognizing pergolide as the cause of CP and accurately diagnosing CP using multimodal imaging may contribute to the early detection and treatment of pergolide-induced CP.

ステントグラフト挿入後に一期的に胸腔鏡下食道切除,再建,下行大動脈置換術を施行し救命し得た大動脈食道瘻の1例
熊谷 健太郎, 海老原 裕磨, 武内 慎太郎, 岡村 国茂, 和田 雅孝, 寺村 紘一, 倉島 庸, 村上 壮一, 七戸 俊明, 若狭 哲, 平野 聡
日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 132回・126回, 58, 58, 日本消化器病学会-北海道支部, Mar. 2023
Japanese

TEVAR術後の下行・胸腹部大動脈手術とアダムキービッツ動脈の意義
佐藤 公治, 鍋島 龍一, 若狭 哲
日本心臓血管外科学会学術総会抄録集, 53回, 490, 490, (NPO)日本心臓血管外科学会, Mar. 2023
Japanese

Impact of right ventricular reserve on exercise capacity and quality of life in patients with left ventricular assist device.
Sakae Takenaka, Takuma Sato, Toshiyuki Nagai, Kazunori Omote, Yuta Kobayashi, Kiwamu Kamiya, Takao Konishi, Atsushi Tada, Yoshifumi Mizuguchi, Yuki Takahashi, Seiichiro Naito, Kohei Saiin, Suguru Ishizaka, Satoru Wakasa, Toshihisa Anzai
American journal of physiology. Heart and circulatory physiology, 324, 3, H355-H363, 01 Mar. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, Although measuring right ventricular (RV) function during exercise is more informative than assessing it at rest, the relationship between RV reserve function, exercise capacity, and health-related quality of life (HRQoL) in patients with left ventricular assist devices (LVAD) remains unresolved. We aimed to investigate whether RV reserve assessed by the change in RV stroke work index (RVSWI) during exercise is correlated with exercise capacity and HRQoL in patients with LVAD. We prospectively assessed 24 consecutive patients with LVAD who underwent invasive right heart catheterization in the supine position. Exercise capacity and HRQoL were assessed using the 6-min walk distance (6 MWD) and peak oxygen consumption (V̇o2) in cardiopulmonary exercise testing, and the EuroQol visual analog scale (EQ-VAS), respectively. The patients were divided into two groups according to the median ΔRVSWI (change from rest to peak exercise). Patients with lower ΔRVSWI had significantly lower changes in cardiac index and absolute value of RV dP/dt than those with higher ΔRVSWI. The ΔRVSWI was positively correlated with 6 MWD (r = 0.59, P = 0.003) and peak V̇o2 (r = 0.56, P = 0.006). In addition, ΔRVSWI was positively correlated with the EQ-VAS (r = 0.44, P = 0.030). In contrast, there was no significant correlation between RVSWI at rest and 6 MWD (r = -0.34, P = 0.88), peak V̇o2 (r = 0.074, P = 0.74), or EQ-VAS (r = 0.127, P = 0.56). Our findings suggest that the assessment of RV reserve function is useful for risk stratification in patients with LVAD.NEW & NOTEWORTHY The change in right ventricular stroke work index (RVSWI) during exercise, not RVSWI at rest, was associated with exercise capacity and HRQoL. Our findings suggest that the assessment of change in RVSWI during exercise as a surrogate of RV reserve function may aid in risk stratification of patients with LVAD.

B型解離に対するTEVAR術後遠隔期におけるRetrograde Type A Dissection　　　　　　　　　　　　　　　
佐藤 公治, 伊藤 大貴, 杉木 宏司, 久保田 卓, 若狭 哲
日本血管外科学会雑誌, 32, Suppl., O18, 2, (NPO)日本血管外科学会, 2023
Japanese

Closed VSDを合併した右室二腔症の手術症例　　　　　　　　　　　　　　　
齋藤 翔太, 石坂 傑, 下野 裕依, 甲谷 太郎, 神谷 究, 阿部 慎司, 加藤 伸康, 永井 利幸, 若狭 哲, 安斉 俊久
日本成人先天性心疾患学会雑誌, 12, 1, 200, 200, (一社)日本成人先天性心疾患学会, Jan. 2023
Japanese

カルニチンを用いた食道癌術後の心房細動予防 探索的単群介入試験　　　　　　　　　　　　　　　
新宮 康栄, 横田 勲, 七戸 俊明, 村上 壮一, 海老原 裕磨, 倉島 庸, 平野 聡, 若狭 哲
日本胸部外科学会定期学術集会, 75回, JP2, 1, (一社)日本胸部外科学会, Oct. 2022
Japanese

TEVAR術後の下行・胸腹部大動脈手術における脊髄保護　　　　　　　　　　　　　　　
佐藤 公治, 鍋島 龍一, 若狭 哲
日本胸部外科学会定期学術集会, 75回, COP15, 4, (一社)日本胸部外科学会, Oct. 2022
Japanese

ステントグラフト内挿術後に外科的治療を要した尿管動脈瘻の1例　　　　　　　　　　　　　　　
杉戸 悠紀, 堀田 記世彦, 山田 修平, 千葉 博基, 松本 隆児, 大澤 崇宏, 安部 崇重, 阿保 大介, 佐藤 公治, 若狭 哲, 篠原 信雄
日本泌尿器科学会雑誌, 113, 4, 134, 138, (一社)日本泌尿器科学会, Oct. 2022
Japanese

ステントグラフト内挿術後に外科的治療を要した尿管動脈瘻の1例　　　　　　　　　　　　　　　
杉戸 悠紀, 堀田 記世彦, 山田 修平, 千葉 博基, 松本 隆児, 大澤 崇宏, 安部 崇重, 阿保 大介, 佐藤 公治, 若狭 哲, 篠原 信雄
日本泌尿器科学会雑誌, 113, 4, 134, 138, (一社)日本泌尿器科学会, Oct. 2022, [Peer-reviewed]
Japanese

Iatrogenic Arteriovenous Fistula of Subclavian Artery to Vertebral Vein with Perimedullary Vein Reflux
Sato Koji, Shingu Yasushige, Fusegawa Masato, Ishigaki Takahiro, Wakasa Satoru
Annals of Vascular Diseases, 15, 3, 193, 196, The Editorial Committee of Annals of Vascular Diseases, 25 Sep. 2022, [Peer-reviewed], [Last author, Corresponding author], [Domestic magazines]
English, Scientific journal, Iatrogenic arteriovenous fistula (AVF) rarely develops around the proximal subclavian artery, although open surgical repair of this etiology is known to be complicated as deep dissection is required around the fistula surrounded by dilated veins. In this study, we present the case of a 64-year-old man, who was referred to our hospital, with AVF between the right subclavian artery and the right vertebral vein. He had a history of accidental puncture of the right subclavian artery. An endovascular repair using a covered stent was successfully performed, and the AVF disappeared. Thus, covered stent placement should be considered as the first-line treatment for a deeply developed AVF, if anatomically feasible.

Changes in Cerebral Hemodynamics During Systemic Pulmonary Shunt and Pulmonary Artery Banding in Infants with Congenital Heart Disease.
Yoshifumi Takeda, Masataka Yamamoto, Koji Hoshino, Yoichi M Ito, Nobuyasu Kato, Satoru Wakasa, Yuji Morimoto
Pediatric cardiology, 44, 3, 695, 701, 01 Sep. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Palliative surgery is often performed in the treatment of congenital heart disease. Two representative palliative procedures are the systemic pulmonary shunt and pulmonary artery banding. Dramatic changes in cerebral hemodynamics may occur in these operations due to changes in the pulmonary-to-systemic blood flow ratio and systemic oxygenation. However, there seem to be almost no studies evaluating them. Accordingly, we evaluated cerebral perfusion by transcranial Doppler ultrasonography and cerebral oxygenation by near infrared spectroscopy during these procedures. In the post hoc analysis of a previous prospective observational study, cerebral blood flow velocities of the middle cerebral artery measured by transcranial Doppler were compared between the start and end of surgery as were the pulsatility index and resistance index. The cerebral oxygenation values were also compared between the start and end of surgery. Twenty-two infants with systemic pulmonary shunt and 20 infants with pulmonary artery banding were evaluated. There were no significant differences of the flow velocities between the start and end of surgery in either procedure. The pulsatility index significantly increased after pulmonary artery banding, which may compete with the increase in cerebral perfusion due to the increase in systemic blood flow. The cerebral oxygenation decreased in both procedures, possibly due to an increase in body temperature. Arterial oxygen saturation was almost the same before and after both procedures. Contrary to our expectation, the changes in cerebral hemodynamics in the palliative operations were small if the management of physiological indices such as arterial oxygen saturation was properly performed during the procedures.

A preliminary prediction model using a deep learning software program for prolonged hospitalization after cardiovascular surgery.
Ryota Murase, Yasushige Shingu, Satoru Wakasa
Surgery today, 53, 3, 393, 395, 05 Aug. 2022, [Peer-reviewed], [Last author], [Domestic magazines]
English, Scientific journal, A prolonged length of hospital stay (LOS) has become an important issue among patients undergoing cardiovascular surgery in our aging society. However, there are no established prediction models for a prolonged LOS. We therefore created a prediction model of a prolonged LOS using a deep learning software program (Prediction One; Sony Network Communications Inc., Tokyo, Japan) using preoperative data. Subjects were 157 patients (121 for training data, 36 for validation data). A prolonged LOS was defined as a more than 30-day postoperative stay due to physical inactivity. The area under the receiver operating characteristic curve and the accuracy of the model in the validation data were 0.806 and 67%, respectively. In conclusion, the preliminary model demonstrated acceptable performance for the prediction of a prolonged LOS after cardiovascular surgery.

A case report of video-assisted flap bronchoplasty for central type typical carcinoid
Yuya Wada, Hideki Ujiie, Ryohei Chiba, Shunsuke Nomura, Aki Fujiwara-Kuroda, Kichizo Kaga, Satoru Wakasa, Tatsuya Kato
VIDEO-ASSISTED THORACIC SURGERY, Aug. 2022
English, Scientific journal

A novel system for analyzing indocyanine green (ICG) fluorescence spectra enables deeper lung tumor localization during thoracoscopic surgery.
Ryohei Chiba, Yuma Ebihara, Haruhiko Shiiya, Hideki Ujiie, Aki Fujiwara-Kuroda, Kichizo Kaga, Liming Li, Satoru Wakasa, Satoshi Hirano, Tatsuya Kato
Journal of thoracic disease, 14, 8, 2943, 2952, Aug. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Background: Palpation of tumors during thoracoscopic surgery remains difficult, and identification of deep-seated tumors may be impossible. This preclinical study investigated the usefulness of a novel indocyanine green (ICG) fluorescence spectroscopy system for tumor localization. Methods: ICG was diluted to 5.0×10-2 mg/mL in fetal bovine serum (FBS) and mixed with silicone resin to prepare pseudo-tumors. Sponges of different densities and a porcine lung were placed on top of the pseudo-tumors, which were examined using a novel fluorescence spectroscopy system and a near-infrared (NIR) camera. Spectra were measured for different sponge and lung thicknesses, and the lung spectra were measured during both inflation and deflation. Results: The fluorescence spectroscopy system was able to identify tumors at depths ≥15 mm, while the NIR system was not. The spectroscopy system also detected tumors at greater depths when the density of the intervening material was lower. Depending on the density and thickness of the intervening material, the system could detect spectra as deep as 40 mm for sponges and 30 mm for lungs. Conclusions: This new fluorescence spectroscopy system can be used to identify lung tumors up to a depth of 30 mm in experiments using pseudo-tumors and a porcine lung, which may aid in tumor identification during thoracoscopic surgery.

Cardioprotective effects of chloroquine pretreatment on ischemic and reperfusion injury via activation of ERK1/2 in isolated rat hearts.
Ryota Murase, Yasushige Shingu, Satoru Wakasa
Molecular biology reports, 49, 10, 9429, 9436, 27 Jul. 2022, [Peer-reviewed], [Last author], [International Magazine]
English, Scientific journal, PURPOSE: Several therapeutic agents have been found to prevent myocardial ischemic and reperfusion (I/R) injury after cardiac surgery; however, no drug is routinely used to afford cardioprotective benefits in clinical settings. Herein, we aimed to determine whether chloroquine (CQ) pretreatment attenuates I/R injury after global ischemia in isolated rat hearts and elucidate mechanisms underlying the effects of CQ. METHODS: Isolated rat hearts were subjected to 30-min global ischemia, followed by 60-min reperfusion with Krebs-Henseleit buffer (KHB). Immediately before ischemia, 10 mL of pretreatment solutions (KHB, n = 4 or KHB + CQ [100 μM], n = 4) were injected through the aortic root. Cardiac function was examined based on the rate pressure product (RPP). Myocardial apoptosis was evaluated using TUNEL staining. To assess the reperfusion ischemia salvage kinase pathway, protein expression levels of AKT and extracellular signal-regulated kinase (ERK1/2) were determined using western blotting. To investigate the role of ERK1/2, an ERK1/2 selective inhibitor was used in eight additional rats. RESULTS: The recovery rate of the RPP was higher in the KHB + CQ group than in the KHB group 60 min after I/R (KHB, 44 ± 3% vs. KHB + CQ, 69 ± 7%; P = 0.019, d = 2.2). CQ pretreatment reduced apoptosis and enhanced the phosphorylation of ERK1/2; however, AKT phosphorylation was unaltered. In addition, the ERK1/2 inhibitor abolished CQ-mediated cardioprotective effects. CONCLUSIONS: CQ pretreatment showed protective effects on cardiac function after I/R by activating ERK1/2.

Achieving Secure Hemostasis in Cardiovascular Surgery
WAKASA Satoru
THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA, 42, 4, 377, 384, THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA, 15 Jul. 2022, [Invited], [Lead author, Corresponding author]
Japanese, Secure hemostasis is essential to achieve good outcomes after cardiovascular surgery because it is associated with less transfusion and shorter hospital stays. However, intraoperative use of anticoagulants and cardiopulmonary bypass can result in a tendency to bleeding and make it difficult to achieve secure hemostasis. The causes of intraoperative bleeding can be classified into surgical bleeding originating from a relatively large bleeding site, which develops during dissection and anastomosis, and consumption coagulopathy associated with a smaller bleeding site which is exaggerated by loss of coagulation factors and platelets due to surgical bleeding and hemodilution by use of cardiopulmonary bypass. Because transfusion alone is less effective in controlling surgical bleeding, the surgeon should control such bleeding in the operative field using surgical procedures to maximize the effect of supplemental treatment by anesthesiologists. To achieve effective and secure intraoperative hemostasis, surgeons and anesthesiologists should cooperate, sharing information about the cause of bleeding and the strategy of hemostasis.

当院の体肺動脈短絡手術の治療成績　　　　　　　　　　　　　　　
加藤 伸康, 阿部 慎司, 新宮 康栄, 加藤 裕貴, 大岡 智学, 泉 岳, 山澤 弘州, 武田 充人, 若狭 哲
日本小児循環器学会総会・学術集会抄録集, 58回, [III, 04], (NPO)日本小児循環器学会, Jul. 2022
Japanese

Effect of Diabetes Mellitus on Outcomes in Patients With Left Ventricular Assist Device - Analysis of Data From a Japanese National Database.
Daisuke Yoshioka, Koichi Toda, Minoru Ono, Norihide Fukushima, Akira Shiose, Yoshikatsu Saiki, Akihiko Usui, Satoru Wakasa, Hiroshi Niinami, Goro Matsumiya, Hirokuni Arai, Yoshiki Sawa, Shigeru Miyagawa
Circulation journal : official journal of the Japanese Circulation Society, 86, 12, 1950, 1958, 01 Jul. 2022, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, BACKGROUND: The objective of this study is to investigate the effect of preoperative diabetes on all-cause mortality and major postoperative complications among patients with continuous-flow left ventricular assist device (LVAD) by using data from a national database.Methods and Results: The 545 study patients who underwent primary HeartMateII implantation between 2013 and 2019 were divided into 2 groups according to their diabetes mellitus (DM) status; patients with DM (n=116) and patients without DM (n=429). First, the on-device survival and incidence of adverse events were evaluated. Second, after adjusting for patients' backgrounds, the change of laboratory data in the 2 groups were compared. Overall, on-device survival at 1, 2, and 3 years was almost equivalent between the 2 groups; it was 95%, 94%, and 91% in patients without DM, and 93%, 91%m and 91% in patients with DM (P=0.468) The incidence of adverse events was similar between 2 groups of patients, except for driveline exit site infection in the adjusted cohort. Cox proportional hazards regression analysis revealed younger age (HR: 0.98 (95% confidence interval (CI): 0.97-0.99, P=0.001) and presence of DM (HR: 1.83 (95% CI: 1.14-2.88), P=0.016) as significant predictors of driveline infection. Laboratory findings revealed no differences between groups throughout the periods. CONCLUSIONS: The clinical results after LVAD implantation in DM patients were comparable with those in non-DM patients, except for the driveline exit site infection.

特集 ファロー四徴症に対する外科治療 : 新生児期・幼少期から成人期まで—Surgery for tetralogy of Fallot from infancy to adulthood
加藤 伸康, 阿部 慎司, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲
北海道外科雑誌 = The Hokkaido journal of surgery / 北海道外科雑誌編集委員会 編, 67, 1, 2, 9, Jun. 2022, [Invited], [Last author]
Japanese

Long-term preservation of functional capacity and quality of life in advanced heart failure patients with bridge to transplant therapy: A report from Japanese nationwide multicenter registry.
Takuma Sato, Yuta Kobayashi, Toshiyuki Nagai, Takeshi Nakatani, Jon Kobashigawa, Yoshikatsu Saiki, Minoru Ono, Satoru Wakasa, Toshihisa Anzai
International journal of cardiology, 356, 66, 72, 01 Jun. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Under the revised heart allocation system in the United States, bridge to transplant (BTT) patients with left ventricular assist device (LVAD) have a longer waitlist period, as they are now lowly prioritized. However, little is known regarding the long-term trajectory of functional capacity (FC) and health-related quality of life (HR-QOL) among BTT-LVAD patients. METHODS: We retrospectively analyzed 442 consecutive patients with BTT-LVAD between April 2013 and May 2019 from a Japanese nationwide registry. FC (New York Heart Association [NYHA] functional class, peak oxygen uptake [VO2], and 6-min walk test [6MWT]) and HR-QOL (European Quality of Life [EQ-5D index] and Visual Analogue Scale [EQ-VAS]) were assessed at baseline and for up to 60 months after LVAD implantation. RESULTS: During the follow-up period of 30 months (IQR 18-42 months), 100 (22.6%) patients underwent transplantation, 37 (8.3%) died, and 14 (3.1%) underwent explantation for recovery. Mean peak VO2, 6MWT distance, EQ-5D index, and EQ-VAS significantly improved 3 months after LVAD implantation (p = 0.0012, p = 0.0037, p < 0.001, p < 0.001, respectively). Furthermore, these improvements were sustained for up to 60 months following LVAD implantation. Major adverse events including device failure, infection, stroke, and bleeding, which occurred within the first 3 months after LVAD implantation may have not affected FC or HR-QOL for up to 60 months (p = 0.15, p = 0.22, respectively). CONCLUSIONS: BTT patients showed long-term preservation of FC and HR-QOL, suggesting that BTT remains an option despite the long waiting time to HTx.

Protective effects of trehalose preconditioning on cardiac and coronary endothelial function through eNOS signaling pathway in a rat model of ischemia-reperfusion injury.
Kenichiro Suno, Yasushige Shingu, Satoru Wakasa
Molecular and cellular biochemistry, 477, 10, 2403, 2414, 17 May 2022, [Peer-reviewed], [Last author], [International Magazine]
English, Scientific journal, Coronary endothelial dysfunction is a major cause of ischemia-reperfusion (I/R) injury. Trehalose, a natural disaccharide, has been reported to ameliorate endothelial dysfunction during aging by activating endothelial nitric oxide synthase (eNOS); however, its role in I/R injury is unknown. This study evaluated the effects of trehalose preconditioning on cardiac and coronary endothelial function after I/R. Langendorff-perfused rat hearts underwent 30 min of global ischemia followed by 80 min of reperfusion with or without trehalose preconditioning. Rate pressure product (RPP) and coronary flow (CF) were measured during reperfusion. Perivascular edema was assessed by hematoxylin and eosin staining. Myocardial oxidative stress and apoptosis were evaluated by immunohistochemistry and TUNEL staining, respectively. eNOS dimerization was determined by western blotting. An eNOS inhibitor was used to examine the role of eNOS. Trehalose preconditioning showed a higher recovery rate after I/R as indicated by high RPP (control vs. trehalose, 28 ± 6% vs. 46 ± 9%; P = 0.017, Cohen's d = 2.3) and CF values (35 ± 10% vs. 55 ± 9%; P = 0.025, d = 1.7). Furthermore, trehalose preconditioning reduced perivascular edema, myocardial oxidative stress, and apoptosis. The eNOS dimerization ratio was increased by trehalose (1.2 ± 0.2 vs. 1.6 ± 0.2; P = 0.023, d = 2.1), which was associated with the recovery of RPP and CF. These effects of trehalose were abolished by the eNOS inhibitor. Trehalose preconditioning showed protective effects on cardiac and coronary endothelial function after I/R through the eNOS signaling pathway.

Changes in AMPKα and Ubiquitin Ligases in Myocyte Reverse Remodeling after Surgical Ventricular Reconstruction in rats with ischemic cardiomyopathy.
Yasushige Shingu, Tetsuya Hieda, Satoshi Sugimoto, Hidetsugu Asai, Tomoji Yamakawa, Satoru Wakasa
Molecular biology reports, 49, 6, 4885, 4892, 08 May 2022, [Peer-reviewed], [Last author], [International Magazine]
English, Scientific journal, BACKGROUND: The change in myocardial protein degradation systems after ventricular unloading has been unknown. We aimed to evaluate the anti-hypertrophic protein adenosine monophosphate-activated protein kinase (AMPK) and two major protein degradation systems (ubiquitin proteasome system and autophagy) in a model of surgical ventricular reconstruction (SVR) in rats with ischemic cardiomyopathy. METHODS AND RESULTS: Rats were randomized into the following groups: sham/sham (control group), myocardial infarction (MI)/sham (sham group) and MI/SVR (SVR group), with an interval of 4 weeks. Two (early, n = 5 for each) and 28 days (late, n = 5 for each) after SVR, ventricular size, and wall stress were assessed. Myocyte area, protein expression of AMPKα and autophagy markers, and gene expression of ubiquitin ligases (Atrogin-1 and Murf-1) were evaluated in the late phase. In the early phase, left ventricular dimensions and wall stress were smaller in the SVR group than in the sham group, whereas they were comparable in the late period. Myocyte area in the SVR group was reduced to the value in the control group, while it was larger in the sham group than in the control group. Total-AMPKα, p-AMPKα, and AMPKα phosphorylation rates were higher, and Atrogin-1 and Murf-1 were lower in the SVR group than in the sham group, while the autophagy markers were not different between the groups. p-AMPKα had strong negative correlations with myocyte area, Atrogin-1, and Murf-1. CONCLUSIONS: In myocyte reverse remodeling after SVR, AMPKα phosphorylation increased in association with reduced gene expression of ubiquitin ligases.

Bronchial artery hypertrophy-associated perioperative pulmonary hemorrhage in cardiovascular surgery: a case report.
Shinji Abe, Yasuhiro Kamikubo, Nobuyasu Kato, Hiroki Kato, Tomonori Ooka, Yasushige Shingu, Satoru Wakasa
Surgical case reports, 8, 1, 80, 80, 29 Apr. 2022, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
English, Scientific journal, BACKGROUND: Pulmonary hemorrhage is a life-threatening complication of cardiovascular surgery. Bronchial artery hypertrophy, a rare pathology associated with inflammatory and ischemic respiratory diseases, increases the risk of pulmonary hemorrhage; however, its involvement in cardiovascular surgery is not well known. We present two cardiovascular surgical cases in which embolization of the hypertrophied bronchial artery was effective in controlling perioperative pulmonary hemorrhage. CASE PRESENTATION: The first case was a 51-year-old man with chronic obstructive pulmonary disease who developed acute type A aortic dissection. After emergent surgery, his blood pressure suddenly dropped in the intensive care unit; computed tomography revealed a right hemothorax. Because a 4-mm dilated bronchial artery was identified on preoperative computed tomography, the hemothorax was suspected to be associated with bronchial artery hypertrophy. Selective bronchial arteriography was emergently performed and revealed a right pulmonary parenchymal blush. After subsequent coil embolization of the bronchial artery, the parenchymal blush disappeared, and his hemodynamic condition stabilized. The second case was a 66-year-old man with bronchiectasis who was referred for redo aortic valve replacement due to structural valve deterioration. A bioprosthesis was previously implanted to avoid permanent anticoagulation because the patient had repeated episodes of hemoptysis; however, he still had persistent hemosputum during admission for the redo aortic valve replacement. A dilated bronchial artery 3.7 mm in size was incidentally identified on preoperative computed tomography, and hence, the repeated hemosputum was suspected to be associated with bronchial artery hypertrophy. Bronchial arteriography revealed a right pulmonary parenchymal blush, and prophylactic embolization of the bronchial artery was performed. The hemosputum disappeared after the procedure, and redo aortic valve replacement was performed uneventfully 8 days later. CONCLUSION: In cardiovascular surgery, the risk of pulmonary hemorrhage associated with bronchial artery hypertrophy should be considered, especially in patients with inflammatory and ischemic respiratory diseases.

A simple closure method for a mechanical aortic valve in left ventricular assist device implantation.
Takahiro Ishigaki, Satoru Wakasa
General thoracic and cardiovascular surgery, 70, 7, 677, 679, 07 Apr. 2022, [Peer-reviewed], [Last author, Corresponding author], [Domestic magazines]
English, Scientific journal, Because a mechanical aortic valve is a contraindication for the implantation of left ventricular assist device, complicated additional procedures such as a replacement with a bioprosthesis and a closure of the left ventricular outflow tract are required to implant the device. Among such procedures, a sandwich plug technique using vascular clips is one of the simple and feasible procedures. However, this technique requires an off-label use of vascular clips within the aorta that could be associated with a risk of dislodgement and embolization. Thus, we developed a modified sandwich technique without using vascular clips, where the valve leaflets were fixed in the closed position using felt patches and sutures instead of vascular clips. This modified technique is a simple and secure method to close the mechanical aortic valve with the minimum use of artificial materials.

Presurgical assessment of flow variability in an azygos vein aneurysm using 4D-flow MRI.
Takuya Ikushima, Hideki Ujiie, Satonori Tsuneta, Ryohei Chiba, Yukiko Tabata, Aki Fujiwara-Kuroda, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Tatsuya Kato
General thoracic and cardiovascular surgery, 70, 7, 673, 676, 06 Apr. 2022, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Azygos vein aneurysm (AVA) is necessary to prevent pulmonary embolism due to the outflow of a thrombus or rupture of the aneurysm. However, there is no established modality to assess the properties of AVA. Time-resolved three-dimensional phase-contrast magnetic resonance imaging (4D-flow MRI) has been used to examine the hemodynamics in various fields. We report a case of AVA to evaluate the flow variability and adhesions of surrounding tissues using 4D-flow MRI. The findings of the study suggested aneurysm turbulence and the absence of thrombi. The cine image, which showed a sliding wall synchronized to the heartbeat, indicated no adhesion to the superior vena cava. Based on these results, the thoracoscopic approach was deemed possible preoperatively. Thoracoscopic AVA resection was performed, and the postoperative course was uneventful. This study documented the utility of 4D-flow MRI for a detailed evaluation of AVA.

Elective Uniportal Video-Assisted Thoracoscopic Lobectomy for Congenital Cystic Lung Disease in a 2-Year-Old Child Using One-Lung Ventilation
Haruhiko Shiiya, Hideki Ujiie, Tatsuya Kato, Shohei Honda, Satoru Wakasa, Kichizo Kaga
INDIAN JOURNAL OF SURGERY, Apr. 2022, [Peer-reviewed]
English, Scientific journal

Chunnel debranching for hybrid repair of thoracoabdominal aortic aneurysm.
Satoru Wakasa, Koji Sato, Takahiro Ishigaki, Yoshinobu Watabe, Shinji Abe
General thoracic and cardiovascular surgery, 70, 6, 588, 590, 21 Mar. 2022, [Peer-reviewed], [Lead author, Corresponding author], [Domestic magazines]
English, Scientific journal, Hybrid repair of a thoracoabdominal aortic aneurysm comprising thoracic endovascular aortic repair and total renovisceral debranching is a feasible alternative to open repair, especially for high-risk patients. However, transperitoneal debranching is a relatively complicated procedure that requires deep dissection around vital abdominal organs. Therefore, we developed a new debranching technique called Chunnel debranching, which was characterized by transaortic tunneling using a covered stent between the target artery and the prosthetic graft anastomosed on the aneurysmal wall using an inclusion technique. This procedure increases the feasibility of renovisceral debranching with fewer dissections than conventional transperitoneal debranching.

Effects of trehalose on recurrence of remodeling after ventricular reconstruction in rats with ischemic cardiomyopathy.
Tetsuya Hieda, Yasushige Shingu, Satoshi Sugimoto, Hidetsugu Asai, Tomoji Yamakawa, Satoru Wakasa
Heart and vessels, 37, 3, 528, 537, Mar. 2022, [Peer-reviewed], [Last author], [Domestic magazines]
English, Scientific journal, Recurrence of left ventricular (LV) remodeling after surgical ventricular reconstruction (SVR) for ischemic cardiomyopathy has been reported to be partially attributed to autophagy. We aimed to examine the effects of trehalose, an autophagy inducer, on the recurrence of LV remodeling after SVR. After SVR in rats with ICM, trehalose was orally administered. The changes in LV end-diastolic dimension (LVEDD) and fractional shortening (FS) were evaluated. The activation of myocardial autophagy was also estimated by autophagy markers: microtubule-associated light chain 3 II (LC3-II) and p62; the former usually increases and the latter decreases if autophagy is activated. Significant LV reverse remodeling was observed early after SVR. On the other hand, the 28th postoperative day SVR + trehalose was associated with smaller LVEDD and better FS than SVR alone (LVEDD, P = 0.043; FS, P < 0.01). LC3-II increased comparably in both groups, while p62 was significantly lower in the SVR + trehalose group than in the SVR alone group (P < 0.01). In conclusion, trehalose attenuated the recurrence of LV remodeling and changed autophagy markers after SVR in rats with ICM. Trehalose may be a candidate for adjuvant therapy to retain the effects of SVR.

切除を先行した巨大(>10cm)肺腫瘤の2症例　　　　　　　　　　　　　　　
千葉 龍平, 加賀 基知三, 幾島 拓也, 田畑 佑希子, 藤原 晶, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 若狭 哲, 岡崎 ななせ, 若林 健人, 松野 吉宏
肺癌, 62, 1, 72, 73, (NPO)日本肺癌学会, Feb. 2022, [Peer-reviewed]
Japanese

JCS 2018 Guideline on Revascularization of Stable Coronary Artery Disease.
Masato Nakamura, Hitoshi Yaku, Junya Ako, Hirokuni Arai, Tohru Asai, Taishiro Chikamori, Hiroyuki Daida, Kiyoshi Doi, Toshihiro Fukui, Toshiaki Ito, Kazushige Kadota, Junjiro Kobayashi, Tatsuhiko Komiya, Ken Kozuma, Yoshihisa Nakagawa, Koichi Nakao, Hiroshi Niinami, Takayuki Ohno, Yukio Ozaki, Masataka Sata, Shuichiro Takanashi, Hirofumi Takemura, Takafumi Ueno, Satoshi Yasuda, Hitoshi Yokoyama, Tomoyuki Fujita, Tokuo Kasai, Shun Kohsaka, Takashi Kubo, Susumu Manabe, Naoya Matsumoto, Shigeru Miyagawa, Tomohiro Mizuno, Noboru Motomura, Satoshi Numata, Hiroyuki Nakajima, Hirotaka Oda, Hiromasa Otake, Fumiyuki Otsuka, Ken-Ichiro Sasaki, Kazunori Shimada, Tomoki Shimokawa, Toshiro Shinke, Tomoaki Suzuki, Masao Takahashi, Nobuhiro Tanaka, Hiroshi Tsuneyoshi, Taiki Tojo, Dai Une, Satoru Wakasa, Koji Yamaguchi, Takashi Akasaka, Atsushi Hirayama, Kazuo Kimura, Takeshi Kimura, Yoshiro Matsui, Shunichi Miyazaki, Yoshitaka Okamura, Minoru Ono, Hiroki Shiomi, Kazuo Tanemoto
Circulation journal : official journal of the Japanese Circulation Society, 86, 3, 477, 588, 31 Jan. 2022, [Invited], [Domestic magazines]
English, Scientific journal

A Surgical Experience of Popliteal Venous Aneurysm Associated with Acute Pulmonary Thromboembolism
Yoshimoto Kimihiro, Wakasa Satoru
Japanese Journal of Cardiovascular Surgery, 51, 1, 53, 56, The Japanese Society for Cardiovascular Surgery, 15 Jan. 2022, [Peer-reviewed], [Last author]
Japanese, Popliteal venous aneurysm (PVA) is recognized as source of fatal pulmonary embolism ; surgical treatment is indicated. A 79-year-old woman presented with acute shortness of breath. A cardiac ultrasound echography showed right heart overload and pulmonary hypertension. A contrast enhanced CT revealed multiple pulmonary artery emboli and right popliteal venous aneurysm. She was immediately started anticoagulation therapy with oral factor Xa inhibitor and her dyspnea improved. As thrombus in venous aneurysm was considered the cause of the pulmonary embolism, we recommended surgical treatment. Tangential aneurysmectomy with lateral venorrhaphy for the saccular venous aneurysm was performed. Postoperative contrast enhanced CT showed good morphology and she was discharged without complication. Surgical treatment of symptomatic popliteal venous aneurysm is considered useful strategy.

Simple Chordal Replacement with a Newly Designed "Mitral Plate" in Mitral Valvuloplasty.
Yoshiro Matsui, Suguru Kubota, Tatsuya Seki, Yasushige Shingu, Satoru Wakasa
The Annals of thoracic surgery, 114, 2, e141-e144, 09 Dec. 2021, [Peer-reviewed], [Last author], [International Magazine]
English, Scientific journal, Mitral valvuloplasty using Gore-Tex as the artificial chordae is often associated with difficulties in determining the length of the artificial chordae, achieving the correct artificial chordae length, and preventing knot slippage, especially for beginners. We describe a simple technique involving a novel device called the "Mitral Plate," which enables surgeons to automatically determine the correct length of the artificial chordae and tie slippery knots without performing excessive saline tests.

α-グルコシダーゼ阻害薬内服中に発症した肺移植後の腸管嚢胞様気腫症の一例—Pneumatosis Intestinalis After Living Donor Lung Transplantation Associated With Alpha-Glucosidase Inhibitor Treatment : A Case Report
大塚 慎也, 氏家 秀樹, 加藤 達哉, 椎谷 洋彦, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 井上 玲, 飯村 泰昭
北海道外科雑誌 = The Hokkaido journal of surgery / 北海道外科雑誌編集委員会 編, 66, 2, 131, 133, 北海道外科学会, Dec. 2021, [Peer-reviewed]
Japanese

Reduction of tethering distance by papillary muscle tugging approximation with mitral valve replacement for non-ischemic functional mitral regurgitation induces left ventricular reverse remodeling
Takahiro Ishigaki, Satoru Wakasa, Yasushige Shingu, Yohei Ohkawa, Akira Yamada, Toshihisa Anzai, Yoshiro Matsui
Journal of Cardiology, 79, 4, 530, 536, Elsevier BV, Nov. 2021, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, BACKGROUND: Functional mitral regurgitation (FMR) is caused by left ventricular (LV) remodeling and subsequent tethering of the mitral valve (MV). If LV remodeling is irreversibly advanced, it could not be attenuated by the MV procedure alone, although the additional subvalvular procedure could induce LV reverse remodeling by forcibly reducing MV tethering. This study aimed to assess the anti-tethering effect of papillary muscle tugging approximation (PMTA) on LV reverse remodeling after mitral valve replacement (MVR) for non-ischemic FMR. METHODS: The study subjects were 19 patients who underwent MVR with and without PMTA [MVR + PMTA (n = 11) and MVR alone (n = 8), respectively] for non-ischemic FMR. The tethering distance (TD) and LV end-systolic volume (ESV) at the preoperative, postoperative, and follow-up periods were assessed in terms of their correlation and time-dependent changes. The intra-LV energy efficiency was also evaluated through vector flow mapping analysis. RESULTS: TD and ESV were comparable between both procedures preoperatively and did not change after MVR alone. In MVR + PMTA, however, a significant decrease was identified in TD and ESV at the early postoperative and follow-up periods, respectively [TD = 48, 30, and 31 mm (p < 0.001) and ESV = 159, 133, and 82 mL (p < 0.001) at the preoperative, postoperative, and follow-up periods, respectively]. Finally, at follow-up, the extent of change from the preoperative value in ESV significantly correlated with that in TD (ρ = 0.81, p < 0.001 for overall; ρ = 0.93, p < 0.001 for MVR + PMTA; ρ = 0.86, p = 0.011 for MVR alone). The ratio of TD to ESV was also significantly correlated with systolic energy loss to LV stroke work after MVR + PMTA (ρ = 0.81, p = 0.015). CONCLUSIONS: PMTA for non-ischemic FMR could induce LV reverse remodeling depending on the extent of postoperative TD reduction. A smaller TD to ESV was associated with a higher intra-LV energy efficiency after PMTA + MVR.

Surgical treatment for tracheal stent prolapse in a patient with blunt tracheal trauma.
Shinya Otsuka, Tatsuya Kato, Hideki Ujiie, Aki Fujiwara-Kuroda, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Yuta Takashima, Naofumi Shinagawa
General thoracic and cardiovascular surgery, 69, 12, 1589, 1592, 28 Sep. 2021, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Blunt tracheal injury is a rare but life-threatening condition. Several indications for treatment have been reported. Conservative treatment (i.e., stenting) can be performed when the patient is clinically stable or has medical contraindications to surgical treatment. Although some studies have reported the use of tracheal stents as treatment for iatrogenic injury and blunt trauma, the efficacy of these stents is unknown. Herein, we report a case of emergency tracheoplasty for the management of tracheal stent prolapse in a patient with blunt tracheobronchial trauma. This report highlights the necessity of being cautious about the migration and prolapse of tracheal stents, which can more frequently occur in blunt trauma than in malignant stenosis or iatrogenic injury. Due to the limitations of non-surgical treatments, early surgical intervention may be lifesaving.

Elevated serum CYFRA 21-1 level as a diagnostic marker for thymic carcinoma.
Haruhiko Shiiya, Hideki Ujiie, Yasuhiro Hida, Tatsuya Kato, Kichizo Kaga, Satoru Wakasa, Eiki Kikuchi, Naofumi Shinagawa, Kazufumi Okada, Yoichi M Ito, Yoshihiro Matsuno
Thoracic cancer, 12, 21, 2933, 2942, 27 Sep. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: No useful tumor markers have been identified for the diagnosis of thymic carcinomas. Serum cytokeratin 19 fragment, measured using the CYFRA 21-1 immunoassay, is used as a tumor marker for squamous cell carcinomas in various malignant tumors. Here, we evaluated the value of CYFRA 21-1 in diagnosing thymic carcinoma. METHODS: We retrospectively reviewed 94 patients with pathological diagnoses of thymic carcinoma or thymoma (32 and 62 patients, respectively) who were referred to our departments between January 2000 and March 2019. Primary outcomes included tumor marker levels and their diagnostic accuracy. RESULTS: Patients with thymic carcinoma were significantly more likely to be male (thymic carcinoma, 68.8%; thymoma, 40.3%; p = 0.02), have an advanced TNM stage (p < 0.01), and a significantly higher CYFRA 21-1 level than those with thymoma (thymic carcinoma: median = 4.2 ng/ml; interquartile range [IQR] = 2.1-6.1 ng/ml vs. thymoma: median = 1.2 ng/ml; IQR = 0.9-1.7 ng/ml; p < 0.01). Receiver operating characteristic curves demonstrated that the area under the curve for CYFRA 21-1 to distinguish thymic carcinoma from thymoma was 0.86 (95% confidence interval [CI]: 0.74-0.93; cutoff = 2.7 ng/ml; sensitivity = 68.8%; specificity = 95.2%). Multivariable analysis demonstrated that CYFRA 21-1 (odds ratio = 25.6; 95% CI: 4.6-141.6; p < 0.01) was an independent predictor for thymic carcinoma after adjusting for TNM stage. CONCLUSIONS: Serum CYFRA 21-1 level may help in diagnosing thymic carcinoma.

Intralobar pulmonary sequestration associated with left main coronary artery obstruction and mitral regurgitation.
Yusuke Motohashi, Tatsuya Kato, Nobuyasu Kato, Masato Aragaki, Aki Fujiwara-Kuroda, Tsuyoshi Tachibana, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa
General thoracic and cardiovascular surgery, 69, 12, 1575, 1579, 21 Sep. 2021, [Peer-reviewed], [Last author], [Domestic magazines]
English, Scientific journal, A 4-year-old boy with left intralobar pulmonary sequestration associated with left main coronary artery obstruction (LMCAO) and severe mitral regurgitation (MR) was admitted to our hospital. Since the patient presented with dyskinesia of the cardiac apex and increased left ventricular end-diastolic volume (LVEDV), left main coronary artery reconstruction and mitral annuloplasty were performed. The enlargement of the left ventricle was improved after sequential surgeries. There was a risk of deterioration of MR and regrowth of LVEDV due to shunt blood flow; therefore, left lower lobectomy and aberrant artery division were performed. This is a very rare case of a patient with pulmonary sequestration associated with LMCAO and severe MR.

Ischemic MR : Touch or No Touch ?
Satoru Wakasa
Japanese Journal of Cardiovascular Surgery, 50, 5, 5, xxxviii, The Japanese Society for Cardiovascular Surgery, 15 Sep. 2021, [Invited], [Lead author]
Japanese, Scientific journal

A Novel Treatment of Widespread Empyema Necessitatis.
Shinya Otsuka, Hideki Ujiie, Kosuke Ishikawa, Takahiro Miura, Satoru Wakasa, Tatsuya Kato
The Annals of thoracic surgery, 112, 6, e471, 04 Sep. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal

Repeated porphyrin lipoprotein-based photodynamic therapy controls distant disease in mouse mesothelioma via the abscopal effect
Jenny Lou, Masato Aragaki, Nicholas Bernards, Tomonari Kinoshita, Jessica Mo, Yamoto Motooka, Tsukasa Ishiwata, Alexander Gregor, Tess Chee, Zhenchian Chen, Juan Chen, Kichizo Kaga, Satoru Wakasa, Gang Zheng, Kazuhiro Yasufuku
NANOPHOTONICS, 10, 12, 3279, 3294, Sep. 2021
English, Scientific journal

三尖弁形成リングの選択と縫着のコツ
柴田利彦, 若狭哲
胸部外科, 74, 9, 652, 653, 01 Sep. 2021, [Invited], [Lead author]
Japanese

Combined treatment of an aortosplenic bypass followed by coil embolization in the treatment of pancreaticoduodenal artery aneurysms caused by median arcuate ligament compression: a report of two cases.
Shuhei Kii, Hirofumi Kamachi, Daisuke Abo, Takuya Kato, Yousuke Tsuruga, Kenji Wakayama, Tatsuhiko Kakisaka, Takeshi Soyama, Toshiya Kamiyama, Tomonori Ooka, Satoru Wakasa, Akinobu Taketomi
Surgical case reports, 7, 1, 174, 174, 04 Aug. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Pancreaticoduodenal artery aneurysms (PDAAs) are rare visceral aneurysms, and prompt intervention/treatment of all PDAAs is recommended at the time of diagnosis to avoid rupture of aneurysms. Herein, we report two cases of PDAA caused by the median arcuate ligament syndrome, treated with surgical revascularization by aortosplenic bypass followed by coil embolization. CASE PRESENTATION: Case 1 A 54-year-old woman presented with a chief complaint of severe epigastralgia and was diagnosed with two large fusiform inferior PDAAs and celiac axis occlusion. To preserve the blood flow of the pancreatic head, duodenum, liver, and spleen, we performed elective surgery to release the MAL along with aortosplenic bypass. At 6 days postoperatively, transcatheter arterial embolization was performed. At the 8-year 6-month follow-up observation, no recurrent perfusion of the embolized PDAAs or rupture had occurred, including the non-embolized small PDAA, and the bypass graft had excellent patency. Case 2 A 39-year-old man who had been in good health was found to have a PDAA with celiac stenosis during a medical checkup. Computed tomography and superior mesenteric arteriography showed severe celiac axis stenosis and a markedly dilated pancreatic arcade with a large saccular PDAA. To preserve the blood flow of the pancreatic arcade, we performed elective surgery to release the MAL along with aortosplenic bypass. At 9 days postoperatively, transcatheter arterial embolization was performed. At the 6-year 7-month follow-up observation, no recurrent perfusion or rupture of the PDAA had occurred, and the bypass graft had excellent patency. CONCLUSION: Combined treatment with bypass surgery and coil embolization can be an effective option for the treatment of PDAAs associated with celiac axis occlusion or severe stenosis.

A Nationwide Survey of Surgical Treatment for Severe Ischemic Mitral Regurgitation.
Akihiro Masuzawa, Tomomitsu Takagi, Hirokuni Arai, Goro Matsumiya, Shuichiro Takanashi, Hitoshi Yaku, Tatsuhiko Komiya, Yoshiro Matsui, Satoru Wakasa, Takashi Kunihara
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 28, 1, 56, 62, 02 Aug. 2021, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, OBJECTIVE: Mitral subvalvular procedures in addition to restrictive annuloplasty are promising for ischemic mitral regurgitation (IMR). However, the prevalence and efficacy of specific subvalvular repair in severe IMR have not been elucidated. This is the first nationwide survey regarding surgeons' attitudes toward IMR in Japan. METHODS: A questionnaire was sent to 543 institutions. From 2015 to 2019, numbers of elective first-time mitral valve replacement (MVR) with/without complete chordal preservation (CCP)/papillary muscle approximation (PMA) and mitral valvuloplasty (MVP) with/without papillary muscle relocation (PMR)/PMA in patients with severe IMR were collected. Concomitant procedures for coronary artery, tricuspid valve, and arrhythmia could be included but left ventricular reconstruction was excluded. RESULTS: Completed questionnaires were received from 286 institutions (52.7%). The majority (90%) had less than 20 cases within 5 years. The number of MVP (1413, 61.5%) surpassed MVR (886, 38.5%). CCP was performed in half of MVR (50.0%), while PMA was included in only 1.9% of MVR. PMA and PMR were also performed infrequently, in only 7.7% and 10.9% of MVP, respectively. CONCLUSION: Japanese surgeons aggressively perform MVP for severe IMR. Subvalvular repair was also aggressively performed in addition to MVR, but not to MVP. A multicenter registry study is in progress.

Intra-Atrial Rerouting of Anomalous Systemic Venous Connection and Septation of Common Atrium in Intracardiac Repair of Complete Atrioventricular Septal Defect with Left Isomerism and Dextrocardia: A Case Report
Kato Nobuyasu, Takeda Atsuhito, Arai Yosuke, Hatta Eiichiro, Yakuwa Satoshi, Shingu Yasushige, Ooka Tomonori, Wakasa Satoru
Pediatric Cardiology and Cardiac Surgery, 37, 2, 126, 132, Japanese Society of Pediatric Cardiology and Cardiac Surgery, 01 Aug. 2021, [Peer-reviewed], [Last author]
Japanese, Left isomerism is frequently associated with anomalous systemic venous connection and common atrium, requiring systemic venous abnormality correction and common-atrium septation in biventricular repair. Our case was a 4-year-old girl diagnosed with left isomerism, dextrocardia, complete atrioventricular septal defect, common atrium, bilateral superior vena cava, and interruption of the inferior vena cava with hemiazygos vein connection. She underwent intracardiac repair with intra-atrial rerouting. Preoperative computed tomography suggested that extracardiac reconstruction of the anomalous systemic vein was inappropriate, and showed that all the pulmonary veins drain to the common chamber in the common atrium. Thus, the blood flow from the right superior vena cava was diverted into the left side of the common atrium through an intra-atrial tunnel. Complete atrioventricular septal defect was repaired with modified one-patch method, and the patch divided the common atrium into the right and left atria. She was discharged on postoperative day 11 without obstruction in systemic and pulmonary venous return. Therefore, if all the pulmonary veins drain to the common chamber, intra-atrial rerouting may effectively correct anomalous systemic venous connection in the septation of the common atrium.

Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery.
Akihiro Sasaki, Tatsuya Kato, Hideki Ujiie, Satoru Wakasa, Setsuyuki Otake, Keisuke Kikuchi, Koichi Ohno
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 28, 6, 448, 452, 16 Jul. 2021, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, INTRODUCTION: Stiff-person syndrome (SPS) is a rare autoimmune neurological disorder. Paraneoplastic SPS associated with malignant tumors such as thymoma occurs in approximately 5% of all SPS cases. We present a rare case of thymoma accompanied by SPS successfully treated using surgery. PRESENTATION OF CASE: A 26-year-old woman presented with lower limbs convulsions and gait disturbance and complained of leg pain. Cerebrospinal fluid and blood test results showed a high level of anti-glutamic acid decarboxylase (GAD) antibodies. Computed tomography showed anterior mediastinal tumor suggestive of a thymoma. She underwent extended thymectomy, and her symptoms gradually improved after surgery. No evidence of recurrent thymoma and SPS has been observed over 44 months. CONCLUSION: Surgical treatment would be effective for patients with SPS and thymoma.

Rare Diagnosis of a Multilobular Pulmonary Mass.
Yoshinobu Watabe, Hideki Ujiie, Yoshihiro Matsuno, Hideaki Fukui, Aki Fujiwara-Kuroda, Tatsuya Kato, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa
Chest, 160, 1, e63-e67, E67, Jul. 2021, [Peer-reviewed], [Last author], [International Magazine]
English, Scientific journal

Blood flow dynamics with four-dimensional flow cardiovascular magnetic resonance in patients with aortic stenosis before and after transcatheter aortic valve replacement.
Hirokazu Komoriyama, Kiwamu Kamiya, Toshiyuki Nagai, Noriko Oyama-Manabe, Satonori Tsuneta, Yuta Kobayashi, Yoshiya Kato, Miwa Sarashina, Kazunori Omote, Takao Konishi, Takuma Sato, Shingo Tsujinaga, Hiroyuki Iwano, Yasushige Shingu, Satoru Wakasa, Toshihisa Anzai
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 23, 1, 81, 81, 28 Jun. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Pre- and post-procedural hemodynamic changes which could affect adverse outcomes in aortic stenosis (AS) patients who undergo transcatheter aortic valve replacement (TAVR) have not been well investigated. Four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) enables accurate analysis of blood flow dynamics such as flow velocity, flow pattern, wall shear stress (WSS), and energy loss (EL). We sought to examine the changes in blood flow dynamics of patients with severe AS who underwent TAVR. METHODS: We examined 32 consecutive severe AS patients who underwent TAVR between May 2018 and June 2019 (17 men, 82 ± 5 years, median left ventricular ejection fraction 61%, 6 self-expanding valve), after excluding those without CMR because of a contraindication or inadequate imaging from the analyses. We analyzed blood flow patterns, WSS and EL in the ascending aorta (AAo), and those changes before and after TAVR using 4D flow CMR. RESULTS: After TAVR, semi-quantified helical flow in the AAo was significantly decreased (1.4 ± 0.6 vs. 1.9 ± 0.8, P = 0.002), whereas vortical flow and eccentricity showed no significant changes. WSS along the ascending aortic circumference was significantly decreased in the left (P = 0.038) and left anterior (P = 0.033) wall at the basal level, right posterior (P = 0.011) and left (P = 0.010) wall at the middle level, and right (P = 0.012), left posterior (P = 0.019) and left anterior (P = 0.028) wall at the upper level. EL in the AAo was significantly decreased (15.6 [10.8-25.1 vs. 25.8 [18.6-36.2]] mW, P = 0.012). Furthermore, a significant negative correlation was observed between EL and effective orifice area index after TAVR (r = - 0.38, P = 0.034). CONCLUSIONS: In severe AS patients undergoing TAVR, 4D flow CMR demonstrates that TAVR improves blood flow dynamics, especially when a larger effective orifice area index is obtained.

4-Dimensional Flow Cardiovascular Magnetic Resonance Imaging of Changes in Blood Flow Dynamics After Surgery for Discrete Subaortic Stenosis.
Hirokazu Komoriyama, Kiwamu Kamiya, Yuta Kobayashi, Satonori Tsuneta, Takao Konishi, Takuma Sato, Hiroyuki Iwano, Toshiyuki Nagai, Satoru Wakasa, Kohsuke Kudo, Toshihisa Anzai
Circulation journal : official journal of the Japanese Circulation Society, 85, 6, 954, 954, 25 May 2021, [Peer-reviewed], [Domestic magazines]
English, Scientific journal

Diabetes Mellitus With Left Ventricular Dysfunction - Optimal Indication of Bilateral Internal Thoracic Artery Grafting?
Satoru Wakasa, Yoshiro Matsui
Circulation journal : official journal of the Japanese Circulation Society, 85, 11, 2002, 2003, 14 May 2021, [Peer-reviewed], [Invited], [Lead author, Corresponding author], [Domestic magazines]
English, Scientific journal

Prediction of Pulmonary Embolism Following Resection of Pulmonary Infarction: A Case Series.
Hiroshi Yamasaki, Hideki Ujiie, Tatsuya Kato, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Yoshihiro Matsuno
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 27, 6, 371, 379, 14 May 2021, [Peer-reviewed], [Domestic magazines]
English, Scientific journal

Pneumatosis Intestinalis After Living Donor Lung Transplantation Associated With Alpha-Glucosidase Inhibitor Treatment: A Case Report.
Shinya Otsuka, Hideki Ujiie, Tatsuya Kato, Haruhiko Shiiya, Aki Fujiwara-Kuroda, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Rei Inoue, Yasuaki Iimura
Transplantation proceedings, 53, 4, 1379, 1381, May 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, INTRODUCTION: Pneumatosis intestinalis (PI) is a rare but critical condition in which gas is found in the bowel wall. Although organ transplant recipients have an increased PI risk because of long-term immunosuppression, alpha-glucosidase inhibitors (α-GI), a standard diabetes therapy, often contribute to PI. However, little is known about the postorgan transplantation relationship between PI and α-GI. To the best of our knowledge, this is the first reported case of PI in a lung transplant recipient treated with α-GI. CASE REPORT: A 59-year-old man underwent hybrid (living-donor and cadaveric) lung transplantation (LTx). The patient was treated with prednisolone and tacrolimus as immunosuppressive therapy and α-GI for diabetes for 4 years. He developed asymptomatic PI 1031 days after transplantation without any acute abdominal finding. After excluding other possible causes of PI, his PI was attributed to α-GI. The suspected α-GI was immediately withdrawn. The patient was managed conservatively with bowel rest and oxygen therapy. After 11 days of α-GI discontinuation, PI improved, and the patient completely recovered. CONCLUSION: Physicians should keep this rare adverse drug reaction in mind when prescribing α-GI, particularly in patients with diabetes after organ transplantation and including LTx. The management strategy for asymptomatic PI caused by α-GI is the immediate discontinuation of α-GI therapy, followed by conservative management initiation.

Feasibility of limited resection for peripheral small-sized non-small cell lung cancer: a retrospective single-center-based study.
Masato Aragaki, Yasuhiro Hida, Tatsuya Kato, Aki Fujiwara-Kuroda, Kichizo Kaga, Satoru Wakasa
Journal of cancer research and clinical oncology, 147, 5, 1519, 1527, May 2021, [Peer-reviewed], [Last author], [International Magazine]
English, Scientific journal, PURPOSE: This study aimed to establish new criteria for limited resection of non-small cell lung cancer (NSCLC) based on computed tomography findings and maximum standardized uptake value (SUVmax). METHODS: Between December 2007 and December 2015, 611 patients underwent lung cancer surgery; of these, 70 with cT1aN0M0 who underwent limited resection were enrolled. Criteria for undergoing intentional limited resection (ILR) were (1) tumor ground-glass opacity (GGO) ratio of ≥ 0.75 and (2) tumor SUVmax ≤ 1.5. Patients who met criteria (1) and (2) underwent partial resection, and those who only met criteria (2) underwent segmentectomy as ILR. The control group was subjected to limited surgery without meeting the criteria. RESULTS: Overall, 45 and 25 patients who met the criteria were included in the ILR and control groups, respectively. In the ILR group, 13 patients underwent partial resection, and 32 underwent segmentectomy; in the control group, 18 patients underwent partial resection and 7 underwent segmentectomy. According to our criteria, no relapsed cases occurred in the ILR group, although six patients showed recurrence of lung cancer in the control group. The 5-year overall survival (OS) rates in the ILR and control groups were 100% and 67.7%, respectively, and the relapse-free survival (RFS) rates were 100% and 61.6%, respectively. The log-rank test showed that this difference was statistically significant (OS: P < 0.0001, RFS: P < 0.0001). CONCLUSIONS: SUVmax may serve as a predictive marker of recurrence to determine the treatment strategy for patients with NSCLC. Patients with low GGO ratio and low SUVmax may be cured by limited resection.

Trehalose preconditioning for transient global myocardial ischemia in rats.
Norihiro Ando, Yasushige Shingu, Kenichiro Suno, Satoru Wakasa
Biochemical and biophysical research communications, 548, 14, 19, 09 Apr. 2021, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
English, Scientific journal, Autophagy is an intracellular pathway that degrades unnecessary proteins and organelles and provides energy substrates during cellular ischemic conditions. Although pharmacological myocardial preconditioning with an autophagy inducer has been reported to protect cells against ischemic reperfusion (I/R), the effects of preconditioning using naturally occurring substances are still unknown. We aimed to examine whether autophagic preconditioning with trehalose improves cardiac function after myocardial stunning by global ischemia in rats. Rat hearts were perfused by oxygenized Krebs Henseleit (KH) solution in Langendorff system. Ten rats were randomized into the following two groups according to the perfusates during the preconditioning: control (KH solution only, n = 5) and trehalose (KH + 2% trehalose, n = 5). After the 35-min preconditioning period and subsequent 20 min of global ischemia, the hearts were reperfused for 60 min. Cardiac function was assessed during the reperfusion. To evaluate autophagy, myocardial protein expression of microtubule-associated protein light chain 3 (LC3) II was evaluated by western blotting. During I/R, a systolic functional parameter, maximum dP/dt was significantly higher; meanwhile, coronary flow tended to be higher in the trehalose group than in the control group. Myocardial LC3-II expression after preconditioning was higher in the trehalose group than in the control group and decreased to the control level after I/R. In conclusion, in a rat model of global myocardial ischemia, trehalose preconditioning improved cardiac function during I/R. Further studies would be needed to identify the mechanism and effects of trehalose preconditioning.

Non-heart transplant surgical approaches with mitral valve operation and surgical ventricular reconstruction for non-ischaemic dilated cardiomyopathy: a Japanese multicenter study.
Yasunori Cho, Satoru Wakasa, Akihiko Usui, Kenji Minatoya, Hirokuni Arai, Hitoshi Yaku, Atsushi Yamaguchi, Tatsuhiko Komiya, Goro Matsumiya, Kimikazu Hamano, Yoshikatsu Saiki, Yoshiro Matsui
General thoracic and cardiovascular surgery, 69, 4, 679, 689, Apr. 2021, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, OBJECTIVES: There is uncertainty over the efficacy of additional surgical ventricular reconstruction (SVR) associated with mitral valve operation for non-ischaemic dilated cardiomyopathy (DCM). This study aims to assess mid-term outcomes of these non-heart transplant surgical approaches for DCM. METHODS: We reviewed retrospectively 106 patients (median age 64, 44 females) who underwent isolated mitral annular plasty (MAP; n = 34), mitral valve replacement (MVR; n = 29), and SVR associated with MAP (SVR + MAP; n = 43) for DCM, in 11 Japanese hospitals. We analysed mid-term outcomes, specifically freedom from cardiac death and cardiac event. RESULTS: Hospital deaths occurred in 16 patients (15.1%) and cardiac deaths in 36 patients (34.0%) during the study period of 4.4 ± 3.5 years. Freedom from cardiac death at 7 years in patients undergoing MAP, MVR, and SVR + MAP were, respectively, 79.1%, 82.6%, and 29.5% (P < 0.0001). Freedom from cardiac event at 7 years in patients undergoing MAP, MVR, and SVR + MAP were, respectively, 42.8%, 59.9%, 22.6% (P = 0.0004). In the multivariable analyses, preoperative tricuspid regurgitation (TR) grade was the only risk factor for both cardiac death and event, whereas MVR for DCM emerged as a protective factor for cardiac event. CONCLUSIONS: This study could not show any benefit of additional SVR, by means of volume reduction, to MAP, because the baseline characteristics were different even after the stratification of DCM grade. MVR can be performed with favorable mid-term outcomes even in patients with advanced DCM, while patients undergoing MAP with/without SVR had more frequent MR recurrence or cardiac events. Interestingly, the right ventricular feature is a predictor of both cardiac death and events, with the TR grade being a predictor of poor mid-term outcomes.

L-Carnitine supplementation for the prevention of postoperative atrial fibrillation in aortic valve surgery.
Yasushige Shingu, Nobuyasu Katoh, Tomonori Ooka, Hiroki Katoh, Satoru Wakasa
General thoracic and cardiovascular surgery, 69, 11, 1460, 1466, 10 Mar. 2021, [Peer-reviewed], [Last author, Corresponding author], [Domestic magazines]
English, Scientific journal, OBJECTIVES: L-Carnitine, a quaternary amine, improves fatty acid metabolism in the heart and has anti-inflammatory effects. Several studies have reported the efficacy of L-carnitine for the prophylaxis of arrhythmia. We assessed the clinical effectiveness of L-carnitine in preventing postoperative atrial fibrillation (POAF) in aortic valve surgery. METHODS: Thirty patients who underwent aortic valve surgery were included. Fifteen patients had no prophylaxis other than conventional measures (control), while 15 patients received oral L-carnitine for 9 days (daily dose of 3 g). The incidence of POAF during 1 week after surgery was compared between the two groups. The multivariable logistic regression analysis for POAF was performed using the pre- and intraoperative parameters. RESULTS: Preoperative characteristics and operative data were comparable between the groups. The POAF rate was significantly lower in the L-carnitine group than in the control (20% and 60%, respectively; P = 0.025). L-Carnitine use was an independently negative predictor for POAF (odds ratio 0.067; 95% confidence interval 0.006-0.768). CONCLUSIONS: L-Carnitine administration may have potential for the prevention of POAF in aortic valve surgery.

A novel Tn antigen epitope-recognizing antibody for MUC1 predicts clinical outcome in patients with primary lung adenocarcinoma.
Tatsuya Kato, Hideki Ujiie, Kanako C Hatanaka, Ayae Nange, Asami Okumura, Kaho Tsubame, Kentato Naruchi, Masaharu Sato, Kichizo Kaga, Yoshihiro Matsuno, Satoru Wakasa, Yutaka Hatanaka
Oncology letters, 21, 3, 202, 202, Mar. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, Mucin 1 (MUC1) expression is upregulated in multiple types of cancer, including lung cancer. However, the conventional anti-MUC1 antibody is not useful for the differentiation of malignant lung tumors and benign lesions due to its limited specificity. Our previous study screened a novel epitope-defined antibody against cancer-associated sugar chain structures that specifically recognizes the MUC1 Tn antigen (MUC1-Tn ED Ab). In the present study, its potential utility as a diagnostic marker and therapeutic tool for lung adenocarcinoma (ADC) was examined. Immunohistochemical analysis of a lung ADC tissue microarray was performed using the MUC1-Tn ED Ab (clone SN-102), and the results were compared with those of another clone and commercially available MUC1 antibodies. The association between positive immunoreactivity of SN-102 and clinicopathologic factors was analyzed. Furthermore, the association between MUC1-Tn expression and epithelial-mesenchymal transition markers and radiological characteristics was analyzed. Moderate or high MUC1-Tn expression (MUC1-Tn-H) was observed in 138 (78.9%) of the 175 lung ADC cases. MUC1-Tn-H was associated with male sex, cigarette smoking, tumor extension, pleural invasion, and higher preoperative serum carcinoembryonic antigen and cytokeratin 19 fragment levels. Tumors with MUC1-Tn-H had higher consolidation/tumor ratios according to computed tomography and greater uptakes of 18F-fluorodeoxyglucose. A total of 46 (26.9%) of the tumors had mesenchymal features, and MUC1-Tn positivity was higher in the mesenchymal group than in the epithelial and intermediate groups (P<0.01 and P<0.01, respectively). Patients with tumors exhibiting MUC1-Tn-H had significantly shorter 5-year overall and disease-free survival times (P=0.011 and P<0.001, respectively). Additionally, MUC1-Tn-H was identified as an independent prognostic factor in multivariate analysis (P=0.024). MUC1-Tn is specific for lung cancer cells and can improve diagnostic capabilities. Additionally, it may be a potential therapeutic target in lung ADC.

Frozen elephant trunk術後早期SINE発生のリスク因子　　　　　　　　　　　　　　　
佐藤 公治, 加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲
日本心臓血管外科学会学術総会抄録集, 51回, OP32, 4, (NPO)日本心臓血管外科学会, Feb. 2021
Japanese

Developing a virtual reality simulation system for preoperative planning of thoracoscopic thoracic surgery.
Hideki Ujiie, Aogu Yamaguchi, Alexander Gregor, Harley Chan, Tatsuya Kato, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Chad Eitel, Tod R Clapp, Kazuhiro Yasufuku
Journal of thoracic disease, 13, 2, 778, 783, Feb. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, Background: Video-assisted thoracoscopic surgery (VATS) has become a standard approach for the treatment of lung cancer. However, its minimally invasive nature limits the field of view and reduces tactile feedback. These limitations make it vital that surgeons thoroughly familiarize themselves with the patient's anatomy preoperatively. We have developed a virtual reality (VR) surgical navigation system using head-mounted displays (HMD). The aim of this study was to investigate the potential utility of this VR simulation system in both preoperative planning and intraoperative assistance, including support during thoracoscopic sublobar resection. Methods: Three-dimensional (3D) polygon data derived from preoperative computed tomography data was loaded into BananaVision software developed at Colorado State University and displayed on an HMD. An interactive 3D reconstruction image was created, in which all the pulmonary structures could be individually imaged. Preoperative resection simulations were performed with patient-individualized reconstructed 3D images. Results: The 3D anatomic structure of pulmonary vessels and a clear vision into the space between the lesion and adjacent tissues were successfully appreciated during preoperative simulation. Surgeons could easily evaluate the real patient's anatomy in preoperative simulations to improve the accuracy and safety of actual surgery. The VR software and HMD allowed surgeons to visualize and interact with real patient data in true 3D providing a unique perspective. Conclusions: This initial experience suggests that a VR simulation with HMD facilitated preoperative simulation. Routine imaging modalities combined with VR systems could substantially improve preoperative planning and contribute to the safety and accuracy of anatomic resection.

Intraoperative real-time hemodynamics in intralobar pulmonary sequestration using indocyanine green and near-infrared thoracoscopy.
Yusuke Motohashi, Tatsuya Kato, Masato Aragaki, Aki Fujiwara-Kuroda, Yasuhiro Hida, Satoru Wakasa, Kichizo Kaga
General thoracic and cardiovascular surgery, 69, 2, 383, 387, Feb. 2021, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, A 33-year-old man with left pulmonary sequestration was admitted to our hospital. We planned left basilar segmentectomy to preserve the lung function, using indocyanine green (ICG) and near-infrared thoracoscopy. The intravenous (IV) administration of ICG (0.1 mg/kg) showed the distribution of fluorescence from the aberrant arteries, blood flow blockage from the aberrant arteries after they were divided, and the superior-basal boundary after the pulmonary artery and vein were divided. In adult patients with intralobar pulmonary sequestration, ICG and near-infrared thoracoscopic techniques are useful to confirm abnormal hemodynamics and demonstrate a safe and successful basilar segmentectomy.

Frozen elephant trunk術後dSINEリスクの検討　　　　　　　　　　　　　　　
佐藤 公治, 加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲
日本血管外科学会雑誌, 30, Suppl., O24, 1, (NPO)日本血管外科学会, 2021
Japanese

A Case of Multiple Cardiac Papillary Fibroelastoma in the Aortic Valve
Kubota Takehiro, Shingu Yasushige, Wakasa Satoru
Japanese Journal of Cardiovascular Surgery, 50, 4, 270, 273, The Japanese Society for Cardiovascular Surgery, 2021, [Peer-reviewed], [Last author]
Japanese,

We report a case of multiple papillary fibroelastoma (PFE) on the aortic valve. A healthy woman in her 60 s was referred to a nearby doctor with the chief complaint of palpitation and was admitted to our hospital for detailed examination. A mobile tumor was found by transthoracic echo, and she was introduced to us. We undertook excision surgery for her. Initially, it was thought to be a single tumor, and a pedunculated tumor adhering to the central aortic side of the left coronary cusp with a length of 7 mm was removed. After closing the aorta, we recognized a remaining mobile tumor by transesophageal echo. We decided to perform cardiac arrest again, and we recognized one tumor with 6 mm long string-like mobile mass on the right and non-coronary commissure of cardiac side, and a thorn-like mass of about 1.5 mm on the non-coronary cusp of the cardiac side. We removed both tumors from the aortic valve using shaving resection and preserved the aortic valve. All of these were found to be PFE pathologically as if they were three tumors that followed the developmental stage of PFE. After surgery, PFE recurrence is extremely rare. In the case of a pedunculated tumor, it is possible to remove the tumor and preserve the valve. However, as in this case, if both sides of the valve were not carefully inspected, it can be overlooked. In addition, small tumor resection could avoid the risk of new cerebral infarction and myocardial infarction due to recurrence and could avoid reoperation.

TREATMENT OF TYPICAL CARCINOID TUMORS
氏家 秀樹, 樋田 泰浩, 大塚 慎也, 佐々木 明洋, 山崎 洋, 藤原 晶, 加藤 達哉, 加賀 基知三, 若狭 哲, 松野 吉宏
日本外科学会雑誌 = Journal of Japan Surgical Society, 122, 1, 18, 25, 日本外科学会, 2021
Japanese

Persistent Fifth Aortic Arch With Left Ventricular Dysfunction and Left Bronchial Obstruction.
Nobuyasu Kato, Tsuyoshi Tachibana, Hidetsugu Asai, Noriyoshi Ebuoka, Yasushige Shingu, Tomonori Ooka, Hiroki Kato, Satoru Wakasa
The Annals of thoracic surgery, 110, 5, e361-e363, Nov. 2020, [Peer-reviewed], [Last author], [International Magazine]
English, Persistent fifth aortic arch (AA) is a rare anomaly in congenital heart disease, which is often associated with aortic obstructive diseases. We report a 7-month-old infant diagnosed with persistent fifth AA with left ventricular dysfunction along with left bronchial malacia due to compression from their own heart. Surgical repair was performed, including AA reconstruction using the fifth AA as an in situ flap to enlarge the fourth AA with end-to-end anastomosis, and external stenting for the left bronchial malacia. Postoperative courses were uneventful. On computed tomography, a reconstructed AA without obstruction and an expanded left bronchus were seen.

肺高血圧を伴う肺動脈閉鎖症/心室中隔欠損症/主要体肺側副動脈の成人例に対して姑息的右室流出路再建を施行した1例
新井 洋輔, 加藤 伸康, 新宮 康栄, 大岡 智学, 若狭 哲, 橘 剛
日本胸部外科学会定期学術集会, 73回, CCPA10, 2, (一社)日本胸部外科学会, Oct. 2020
Japanese

長期VAD治療の現状と課題 新規大動脈閉鎖不全と感染症に対する治療戦略
大岡 智学, 布施川 真哲, 鍋島 龍二, 小市 裕太, 稗田 哲也, 安東 悟央, 石垣 隆弘, 佐藤 公治, 加藤 伸康, 加藤 裕貴, 新宮 康栄, 若狭 哲
日本胸部外科学会定期学術集会, 73回, CLO19, 1, (一社)日本胸部外科学会, Oct. 2020
Japanese

胸腹部大動脈瘤手術時の肋間動脈再建法の工夫と脊髄保護 internal cuff reimplantation法の有用性
佐藤 公治, 杉本 聡, 加藤 伸康, 新宮 康栄, 杉木 宏司, 加藤 裕貴, 大岡 智学, 若狭 哲
日本胸部外科学会定期学術集会, 73回, CTA1, 5, (一社)日本胸部外科学会, Oct. 2020
Japanese

心嚢ドレナージ術と食道減圧ドレナージ術で保存的に軽快した食道心嚢瘻の一例　　　　　　　　　　　　　　　
植木 知音, 東嶋 宏泰, 楢崎 肇, 倉島 庸, 海老原 裕磨, 村上 壮一, 七戸 俊明, 若狭 哲, 平野 聡
日本胸部外科学会定期学術集会, 73回, ECPA1, 2, (一社)日本胸部外科学会, Oct. 2020
Japanese

Preoperative identification of clinicopathological prognostic factors for relapse-free survival in clinical N1 non-small cell lung cancer: a retrospective single center-based study.
Masato Aragaki, Tatsuya Kato, Aki Fujiwara-Kuroda, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa
Journal of cardiothoracic surgery, 15, 1, 229, 229, 28 Aug. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Given the difficulty in preoperatively diagnosing lymph node metastasis, patients with Stage I-III non-small cell lung cancer (NSCLC) are likely to be included in the clinical N1 (cN1) group. However, better treatment options might be selected through further stratification. This study aimed to identify preoperative clinicopathological prognostic and stratification factors for patients with cN1 NSCLC. METHODS: This retrospective study evaluated 60 patients who were diagnosed with NSCLC during 2004-2014. Clinical nodal status had been evaluated using routine chest computed tomography (CT) and/or positron emission tomography (PET). To avoid biasing the fluorodeoxyglucose uptake values based on inter-institution or inter-model differences, we used only two PET systems (one PET system and one PET/CT system). Relapse-free survival (RFS) and overall survival (OS) were the primary study outcomes. The maximum standardized uptake value (SUVmax) was calculated for each tumor and categorized as low or high based on the median value. Patient sex, age, histology, tumor size, and tumor markers were also assessed. RESULTS: Poor OS was associated with older age (P = 0.0159) and high SUVmax values (P = 0.0142). Poor RFS was associated with positive carcinoembryonic antigen (CEA) expression (P = 0.0035) and high SUVmax values (P = 0.015). Multivariate analyses confirmed that poor OS was independently predicted by older age (hazard ratio [HR] = 2.751, confidence interval [CI]: 1.300-5.822; P = 0.0081) and high SUVmax values (HR = 5.121, 95% CI: 1.759-14.910; P = 0.0027). Furthermore, poor RFS was independently predicted by positive CEA expression (HR = 2.376, 95% CI: 1.056-5.348; P = 0.0366) and high SUVmax values (HR = 2.789, 95% CI: 1.042-7.458; P = 0.0410). The primary tumor's SUVmax value was also an independent prognostic factor for both OS and RFS. CONCLUSIONS: For patients with cN1 NSCLC, preoperative prognosis and stratification might be performed based on CEA expression, age, and the primary tumor's SUVmax value. To enhance the prognostic value of the primary tumor's SUVmax value, minimizing bias between facilities and models could lead to a more accurate prognostication.

Phosphoglyceride crystal deposition disease as a rare tumour after cardiac surgery.
Tomoya Sato, Takao Konishi, Satoru Wakasa, Noriko Oyama-Manabe, Toshihisa Anzai
European heart journal, 41, 27, 2596, 2596, 14 Jul. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal

Video-assisted Thoracoscopic Surgery for Congenital Cystic Lung Diseases in Children
加賀 基知三, 樋田 泰浩, 加藤 達哉, 藤原(黒田) 晶, 椎名 伸行, 氏家 秀樹, 佐々木 明洋, 山崎 洋, 若狭 哲
北海道外科雑誌 = The Hokkaido journal of surgery, 65, 1, 2, 7, 北海道外科学会, Jun. 2020, [Last author]
Japanese

Autophagy during left ventricular redilation after ventriculoplasty: Insights from a rat model of ischemic cardiomyopathy.
Satoshi Sugimoto, Yasushige Shingu, Torsten Doenst, Tomoji Yamakawa, Hidetsugu Asai, Satoru Wakasa, Yoshiro Matsui
The Journal of thoracic and cardiovascular surgery, 19 Feb. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: Myocardial autophagy has been recognized as an important factor in heart failure. It is not known whether changes in ventricular geometry by left ventriculoplasty influence autophagy in ischemic cardiomyopathy. We hypothesized that myocardial autophagy plays an important role in left ventricular (LV) redilation after ventriculoplasty. METHODS: Four weeks after ligation of the left anterior descending artery, ventriculoplasty or sham operation was performed. The animals were euthanized at 2 days (early) or 28 days (late) after the second operation. Ventricular autophagy was evaluated by protein expression of microtubule-associated protein light chain 3 II, an autophagosome marker. Cardiomyocyte area was assessed by histologic examination. LV function was evaluated by echocardiography. To examine the implications of autophagy, an autophagy inhibitor (3-methyladenine) was injected intraperitoneally for 3 weeks before sacrifice. RESULTS: The LV was reduced in size early and redilated late after ventriculoplasty. LV systolic function was improved early and later worsened after ventriculoplasty. Light chain 3 II expression decreased early after ventriculoplasty and increased in the late period. Myocyte area increased from the early to late stage after ventriculoplasty. Autophagic inhibition exaggerated the increased myocyte hypertrophy and LV redilation. CONCLUSIONS: In a rat model of myocardial infarction, autophagy decreased early after ventriculoplasty and increased again during LV redilation. These results provide new insights into the mechanism underlying the late failure of ventriculoplasty.

ステントグラフト温存型動脈瘤切除術の中間成績(Midterm results of stent graft-conserving aneurysmorrhaphy)　　　　　　　　　　　　　　　
佐藤 公治, 若狭 哲, 新宮 康栄, 杉木 宏司, 加藤 裕貴, 大岡 智学
日本血管外科学会雑誌, 29, Suppl., SY11, 5, (NPO)日本血管外科学会, 2020
English

ステントグラフト温存型動脈瘤切除術の中間成績(Midterm results of stent graft-conserving aneurysmorrhaphy)　　　　　　　　　　　　　　　
佐藤 公治, 若狭 哲, 新宮 康栄, 杉木 宏司, 加藤 裕貴, 大岡 智学
日本血管外科学会雑誌, 29, Suppl., SY11, 5, (NPO)日本血管外科学会, 2020
English

Perioperative changes of the slope in the preload recruitable stroke work relationship by a single-beat technique after mitral valve surgery in functional mitral regurgitation with non-ischemic dilated cardiomyopathy.
Takahiro Ishigaki, Yasushige Shingu, Nobuyasu Katoh, Satoru Wakasa, Hiroki Katoh, Tomonori Ooka, Suguru Kubota, Yoshiro Matsui
General thoracic and cardiovascular surgery, 68, 1, 30, 37, Jan. 2020, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, OBJECTIVES: The slope in the preload recruitable stroke work relationship is a highly linear, load-insensitive contractile parameter. However, the perioperative change of the slope has not been reported before. We examined the perioperative slope from a steady-state single beat in patients with functional mitral regurgitation and assessed the correlation with brain natriuretic peptide (BNP) levels. METHODS: The study included 16 patients with non-ischemic dilated cardiomyopathy and refractory heart failure: 10 patients underwent mitral valve plasty and left ventricular plasty (MVP + LVP group) and 6 patients who underwent mitral valve replacement and papillary muscle tugging approximation (MVR + PMTA group). The left ventricular ejection fraction was assessed by the modified Simpson method; the slope was assessed by the single-beat technique using transthoracic echocardiography. BNP levels were measured by chemiluminescent immunoassay. RESULTS: The left ventricular ejection fraction and slope did not significantly change from pre- to early post-surgery in the MVP + LVP group. Both the left ventricular ejection fraction and slope significantly increased 6 months after surgery in the MVR + PMTA group. Postoperative BNP level was low in the MVR + PMTA group. While the postoperative left ventricular ejection fraction did not correlate with BNP levels, the postoperative slope significantly correlated with BNP level after surgery in the MVP + LVP group and in the total functional mitral regurgitation group. CONCLUSIONS: The change of slope was dependent on surgical procedures. In functional mitral regurgitation, the slope may be a more sensitive parameter in reflecting the left ventricular contractile function than the left ventricular ejection fraction.

卵円孔開存による慢性の右左シャントとplatypnea-orthodeoxia syndromeを合併した重症右心不全の1例　　　　　　　　　　　　　　　
佐藤 隆博, 伊東 直史, 魚住 健志, 児島 裕一, 須野 賢一郎, 佐藤 公治, 松名 伸記, 白井 真也, 若狭 哲, 神垣 光徳
KKR札幌医療センター医学雑誌, 16, 1, 59, 62, KKR札幌医療センター, Dec. 2019
Japanese

The optimal treatment strategy for secondary mitral regurgitation: a subject of ongoing debate.
Annelieke H J Petrus, Robert J M Klautz, Michele De Bonis, Frank Langer, Hans-Joachim Schäfers, Satoru Wakasa, Alec Vahanian, Jean-Francois Obadia, Roland Assi, Michael Acker, Matthias Siepe, Jerry Braun
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 56, 4, 631, 642, 01 Oct. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal

Re-do mitral valve replacement for a bioprosthetic valve with central transvalvular leakage in a patient with ischemic cardiomyopathy: a case report.
Tatsuya Seki, Yasushige Shingu, Satoru Wakasa, Hiroki Katoh, Tomonori Ooka, Tsuyoshi Tachibana, Suguru Kubota, Yoshiro Matsui
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 22, 2, 177, 180, Jun. 2019, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Transvalvular leakage (TVL) of a prosthetic heart valve is not negligible regurgitant flow in patients with critically low contractile function. Although the opening function of prosthetic valves has been reported, its closing function is not well understood. A man in his 70 s had a history of mitral valve replacement (MVR) with a Magna Mitral® valve for ischemic mitral valve regurgitation. He presented with dyspnea 2 years postoperatively. Echocardiography showed moderate TVL. The pulmonary capillary wedge pressure and cardiac index were 37 mmHg and 1.65 L/min/m2, respectively. Because we considered his TVL relevant, we performed re-do MVR with a mechanical valve and papillary muscle approximation and suspension ("papillary muscle tugging approximation"). His cardiac function improved postoperatively; he was discharged with New York Heart Association class I. For MVR in patients with critically low contractile function, prosthetic valves, such as mechanical valves, with small TVL are recommended.

Mechanical properties of a new thermally deformable mitral valve annuloplasty ring and its effects on the mitral valve.
Tatsuya Seki, Katsuyoshi Jimuro, Yasushige Shingu, Satoru Wakasa, Hiroki Katoh, Tomonori Ooka, Tsuyoshi Tachibana, Suguru Kubota, Toshiro Ohashi, Yoshiro Matsui
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 22, 2, 126, 133, Jun. 2019, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Ideally, an annuloplasty ring's shape should be changed intraoperatively if mitral valve repair is unsuccessful because of a short coaptation length or systolic anterior motion. Several post-implantation adjustable rings have been developed, but they are not freely deformable and are unsuitable for asymmetric repair of the valvular annulus. We developed a novel thermally deformable mitral annuloplasty ring to address these problems and assessed the ring's mechanical properties and its effect on the mitral valve anatomy. This ring was made of polycaprolactone. Tensile and bending tests were performed to evaluate the ring's mechanical properties. The ratio of the transverse and septal-lateral length was determined as 4:3. Using 10 pig hearts, we measured the post-deformation coaptation length and minimum distance from the coaptation to the ventricular septum, which is a factor of abnormal systolic anterior motion of the mitral valve. In the mechanical tests, the ring's yield point was greater than the deformation force of the annulus in humans. In pigs with deformation from "4:3" to "4:2", the coaptation length was significantly increased in each mitral valve part. In pigs with deformation from "4:3" to "4:4", the minimum distance from the coaptation to the ventricular septum was significantly increased. Asymmetrical ring deformation increased the coaptation length only at the deformed area. In conclusion, this new thermally deformable mitral annuloplasty ring could be "order-made" to effectively change the coaptation length in all parts of the mitral valve and the distance from the coaptation to septum post-deformation via intraoperative heating.

Papillary Muscle Tugging Approximation for Functional Mitral Regurgitation.
Yoshiro Matsui, Yasushige Shingu, Satoru Wakasa, Tomonori Ooka, Suguru Kubota
The Annals of thoracic surgery, 107, 6, e427-e429, e429, Jun. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, The surgical approach is challenging for patients with severe functional mitral regurgitation with nonischemic/ischemic dilated cardiomyopathy who are unsuitable for heart transplantation or ventricular assist device implantation. We developed a new surgical treatment named papillary muscle tugging approximation combined with mitral valve replacement. This technique is safe and feasible, with excellent midterm outcomes.

Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis.
Takayuki Nakajima, Takashi Yokota, Yasushige Shingu, Akira Yamada, Yutaka Iba, Kosuke Ujihira, Satoru Wakasa, Tomonori Ooka, Shingo Takada, Ryosuke Shirakawa, Takashi Katayama, Takaaki Furihata, Arata Fukushima, Ryosuke Matsuoka, Hiroshi Nishihara, Flemming Dela, Katsuhiko Nakanishi, Yoshiro Matsui, Shintaro Kinugawa
Scientific reports, 9, 1, 3535, 3535, 05 Mar. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Epicardial adipose tissue (EAT), a source of adipokines, is metabolically active, but the role of EAT mitochondria in coronary artery disease (CAD) has not been established. We investigated the association between EAT mitochondrial respiratory capacity, adiponectin concentration in the EAT, and coronary atherosclerosis. EAT samples were obtained from 25 patients who underwent elective cardiac surgery. Based on the coronary angiographycal findings, the patients were divided into two groups; coronary artery disease (CAD; n = 14) and non-CAD (n = 11) groups. The mitochondrial respiratory capacities including oxidative phosphorylation (OXPHOS) capacity with non-fatty acid (complex I and complex I + II-linked) substrates and fatty acids in the EAT were significantly lowered in CAD patients. The EAT mitochondrial OXPHOS capacities had a close and inverse correlation with the severity of coronary artery stenosis evaluated by the Gensini score. Intriguingly, the protein level of adiponectin, an anti-atherogenic adipokine, in the EAT was significantly reduced in CAD patients, and it was positively correlated with the mitochondrial OXPHOS capacities in the EAT and inversely correlated with the Gensini score. Our study showed that impaired mitochondrial OXPHOS capacity in the EAT was closely linked to decreased concentration of adiponectin in the EAT and severity of coronary atherosclerosis.

Quantitative analysis of regional endocardial geometry dynamics from 4D cardiac CT images: endocardial tracking based on the iterative closest point with an integrated scale estimation.
Kazuya Kobayashi, Satoru Wakasa, Koji Sato, Satoshi Kanai, Hiroaki Date, Satomi Kimura, Noriko Oyama-Manabe, Yoshiro Matsui
Physics in medicine and biology, 64, 5, 055009, 055009, 25 Feb. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Regional cardiac function analysis is important for the diagnosis and treatment planning of ischemic heart disease, but has not been sufficiently developed in the field of computed tomography (CT). Therefore, we propose a 3D endocardial tracking framework for cardiac CT using local point cloud registration based on the iterative closest point with an integrated scale estimation algorithm. We also introduce regional function descriptors that express the curvature and stretching of the endocardium: Surface distortion (E) and Scaling rate (S). For a region-to-region comparison, we propose endocardial segmentation according to coronary perfusion territories defined by the Voronoi partition based on coronary distribution. Our study of 65 endocardial segments in ten subjects showed that global endocardial deformation has a positive relationship with the stroke volume index (r  =  0.896 and 0.829 in [Formula: see text] and [Formula: see text], respectively) and ejection fraction (r  =  0.804 and 0.835), and a positive relationship with the brain natriuretic peptide level (r  =  0.690 and 0.776). A positive relationship between segmental E and S (r  =  0.845), a higher value of E in ischemic segments (p   =  0.021) that are determined by fractional flow reserve estimated from coronary CT data, and a higher value of S in the left circumflex artery territory (p   <  0.05) were also observed. The required radiation dose was 5.0  ±  0.7 mSv and the computation time was 7.2  ±  1.1 min. The result suggests that proposed endocardial deformation analysis using CT can be conducted on site and in time for the acute setting, and may be useful for the diagnosis of cardiac dysfunction or myocardial ischemia.

Surgery for Left Ventricular Aneurysm and Thrombus Causing Embolic Stroke 26 Years after Penetrating Cardiac Injury : A Case Report
Sato Koji, Suno Kenichiro, Wakasa Satoru
Japanese Journal of Cardiovascular Surgery, 48, 4, 254, 258, The Japanese Society for Cardiovascular Surgery, 2019, [Peer-reviewed], [Last author, Corresponding author]
Japanese,

A 41-year-old man who had a history of suicide attempt by self-stabbing of the chest at the age of 15 and surgical repair of the stab wound of the heart was transferred to a neurosurgical hospital suffering from right hemiparesis. Stroke was diagnosed and he successfully underwent endovascular thrombectomy but postoperative computed tomography revealed left ventricular aneurysm and intracavitary thrombus that could have caused the embolic stroke. He was transferred to our hospital for cardiac surgery to prevent another embolization. Although an emergency operation had been attempted for the large and mobile thrombus, the patient was carefully observed for 4 weeks prior to surgery because of acute and huge stroke with a high risk of perioperative intracranial hemorrhage. After a fortunately uneventful observation, thrombectomy with left ventriculoplasty was performed successfully and the postoperative course was uneventful without neurological impairment. To prevent a fatal embolic event, postoperative follow-up after successful repair of cardiac injury is mandatory.

A Case of Left Atrial Villous-Type Myxoma Mimicking Papillary Fibroelastoma
Ishigaki Takahiro, Shingu Yasushige, Kato Nobuyasu, Wakasa Satoru, Ooka Tomonori, Katoh Hiroki, Matsui Yoshiro
Japanese Journal of Cardiovascular Surgery, 48, 6, 405, 410, The Japanese Society for Cardiovascular Surgery, 2019, [Peer-reviewed]
Japanese,

A female in her 60 s with a mobile cardiac tumor in the left atrium was referred to our hospital. The tumor was diagnosed as myxoma by echocardiography, CT scan, and MRI. Under cardiac arrest using cardiopulmonary bypass, we resected the tumor through the superior trans-septal approach. We resected two tumors (tumor 1 and 2) with adequate rims of the interatrial septum to avoid recurrence. Although the tumor had a broad base and extended to near the mitral annulus, mitral valve repair was not necessary. Tumor 1 was gelatinous and seemed to be a myxoma ; tumor 2 had a lot of papillary structures attached to the solid mass and presented with the figure of a sea anemone when it was put in saline, which is typical for papillary fibroelastomas. The defect of the interatrial septum was closed with the autologous pericardium. The postoperative course was uneventful. Unexpectedly, both tumor 1 and 2 were diagnosed as myxomas on pathological examination. Tumor 2 (papillary lesion) included a few tumor cells with positive staining of calretinin typical for myxoma and was diagnosed as a "villous-type myxoma". Because it is difficult to distinguish myxoma from papillary fibroelastoma by pre- and intraoperative findings, it would be recommended to resect tumors with an adequate margin to prevent recurrence.

Estimating postoperative left ventricular volume: Identification of responders to surgical ventricular reconstruction.
Satoru Wakasa, Yoshiro Matsui, Junjiro Kobayashi, Yasunori Cho, Hitoshi Yaku, Goro Matsumiya, Tadashi Isomura, Shuichiro Takanashi, Akihiko Usui, Ryuzo Sakata, Tatsuhiko Komiya, Yoshiki Sawa, Yoshikatsu Saiki, Hideyuki Shimizu, Atsushi Yamaguchi, Kimikazu Hamano, Hirokuni Arai
The Journal of thoracic and cardiovascular surgery, 156, 6, 2088, 2096, Dec. 2018, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal, OBJECTIVES: The postoperative left ventricular end-systolic volume index and ejection fraction are benchmarks of surgical ventricular reconstruction but remain unpredictable. This study aimed to identify who could be associated with a higher long-term survival by adding surgical ventricular reconstruction to coronary artery bypass grafting than coronary artery bypass grafting alone (responders to surgical ventricular reconstruction). METHODS: The subjects were 293 patients (median age, 63 years; 255 men) who underwent coronary artery bypass grafting for ischemic heart disease with left ventricular dysfunction in 16 cardiovascular centers in Japan. The relationships among surgical ventricular reconstruction, postoperative end-systolic volume index, ejection fraction, and survival were analyzed to identify responders to surgical ventricular reconstruction. RESULTS: Surgical ventricular reconstruction was performed in 165 patients (56%). The end-systolic volume index and ejection fraction significantly improved (end-systolic volume index, 91 to 64 mL/m2; ejection fraction, 28% to 35%) for all patients. The postoperative end-systolic volume index and ejection fraction were estimated, and surgical ventricular reconstruction was found to be significantly associated with both end-systolic volume index (14.5 mL/m2 reduction, P < .001) and ejection fraction (3.1% increase, P = .003). During the median follow-up of 6.8 years, 69 patients (24%) died. Only the postoperative ejection fraction was significantly associated with survival (hazard ratio, 0.925; 95% confidence interval, 0.885-0.968), although this effect was limited to those with postoperative end-systolic volume index of 40 to 80 mL/m2 in the subgroup analysis (hazard ratio, 0.932; 95% confidence interval, 0.894-0.973). CONCLUSIONS: Adding surgical ventricular reconstruction to coronary artery bypass grafting could reduce the mortality risk by increasing ejection fraction for those with a postoperative end-systolic volume index within a specific range. The postoperative end-systolic volume index could demarcate responders to surgical ventricular reconstruction, and its estimation can help in surgical decision making.

Modified total cavopulmonary shunt as a staged Fontan operation.
Hidetsugu Asai, Tsuyoshi Tachibana, Yasushige Shingu, Hiroki Kato, Satoru Wakasa, Yoshiro Matsui
Asian cardiovascular & thoracic annals, 26, 9, 701, 703, Nov. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, The left superior vena cava became occluded in an infant with hypoplastic left heart syndrome. After a bidirectional Glenn procedure, he presented with severe oxygen desaturation and right ventricular dysfunction; the left superior vena cava drained into the inferior vena cava through collateral veins. As salvage therapy, we created a modified total cavopulmonary shunt using only autologous tissue in which the right hepatic vein and inferior vena cava drained into the pulmonary artery via a lateral tunnel in the right atrium. Immediately after surgery, his oxygen saturation increased and right ventricular function improved.

Anticoagulation management during cardiopulmonary bypass in patients with antiphospholipid syndrome.
Tatsuya Seki, Yasushige Shingu, Hiroshi Sugiki, Satoru Wakasa, Hiroki Katoh, Tomonori Ooka, Tsuyoshi Tachibana, Suguru Kubota, Yoshiro Matsui
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 21, 3, 363, 366, Sep. 2018, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Antiphospholipid syndrome (APS) is a complex autoimmune disease often related to systemic lupus erythematosus. Although adequate anticoagulation is important for APS patients during cardiopulmonary bypass, clotting tests can be potentially misleading due to antiphospholipid antibodies. We performed cardiac surgery safely in two APS patients under anticoagulation monitoring determined using preoperative heparin titration. We performed heparin titration for activated clotting time to determine the appropriate heparin concentration during cardiac surgery. We changed the targeted heparin concentration considering each patient's thrombotic risks: 3 U/ml of heparin for a normal-risk APS patient and 5 U/ml for a high-risk APS patient with a history of antiphospholipid-antibody-associated thrombocytopenia. A higher targeted heparin concentration might be necessary for patients with high thrombotic risks.

Surgery for Left Ventricular Outflow Tract Obstruction with a Relatively Thin Interventricular Septum.
Yasushige Shingu, Hiroshi Sugiki, Tomonori Ooka, Hiroki Kato, Satoru Wakasa, Tsuyoshi Tachibana, Yoshiro Matsui
The Thoracic and cardiovascular surgeon, 66, 4, 307, 312, Jun. 2018, [Peer-reviewed], [International Magazine]
English, BACKGROUND: To examine the results of myectomy and mitral valve surgery for systolic anterior motion (SAM) of the mitral valve and left ventricular outflow tract obstruction (LVOTO) with a relatively thin interventricular septum. METHODS: The subjects were 12 patients with SAM and LVOTO. Eight had hypertrophic obstructive cardiomyopathy (HOCM) with a mean interventricular septal thickness of 16 mm. Three had sigmoid septum and one had an unknown etiology. For HOCM, isolated extended myectomy was performed when mitral regurgitation was mild (n = 1) and extended myectomy plus mitral valve surgery was performed when mitral regurgitation was more than mild (n = 4) or primary valve etiologies existed (n = 3). Myectomy was performed for the three cases with sigmoid septum. Myectomy plus height reduction of the posterior mitral leaflet was performed for the one case with the unknown etiology of SAM. RESULTS: In the patients with HOCM, the maximum LVOT pressure gradient significantly decreased from 140 ± 18 to 16 ± 6 and 3 ± 3 mm Hg, while mitral regurgitation significantly decreased from 2.3 ± 0.5 to 0.5 ± 0.3 and 0.4 ± 0.2 at pre-op, early post-op, and last follow-up (3 ± 1 years), respectively. In the other etiologies, the maximum LVOT pressure gradient changed from 56 ± 15 to 25 ± 15 and 5 ± 4 mm Hg; mitral regurgitation changed from 2.0 ± 0.6 to 1.3 ± 0.3 and 1.3 ± 0.8, at pre-op, early post-op, and the last follow-up (3 ± 2 years), respectively. CONCLUSION: Myectomy with mitral valve surgery is an option for SAM and LVOTO in patients with a relatively thin interventricular septum.

心外膜脂肪組織におけるミトコンドリア機能障害は冠動脈狭窄と関連している(Mitochondrial Dysfunction in Epicardial Adipose Tissue is Associated with Coronary Artery Stenosis)　　　　　　　　　　　　　　　
Nakajima Takayuki, Yokota Takashi, Shingu Yasushige, Yamada Akira, Iba Yutaka, Ujihira Kosuke, Wakasa Satoru, Ooka Tomonori, Takada Shingo, Shirakawa Ryosuke, Furihata Takaaki, Tsuda Masaya, Matsumoto Junichi, Katayama Takashi, Fukushima Arata, Saito Akimichi, Matsuoka Ryosuke, Nishihara Hiroshi, Matsui Yoshiro, Kinugawa Shintaro
日本循環器学会学術集会抄録集, 82回, YIA, 1, (一社)日本循環器学会, Mar. 2018
English

A Surgical Case for a Huge Pulmonary Artery Aneurysm 40 Years after Waterston Operation
Ando Norihiro, Matsui Yoshiro, Tachibana Tsuyoshi, Kato Nobuyasu, Arimura Satoshi, Asai Hidetsugu, Shingu Yasushige, Wakasa Satoru, Kato Hiroki, Ooka Tomonori
Japanese Journal of Cardiovascular Surgery, 47, 1, 13, 17, The Japanese Society for Cardiovascular Surgery, 2018
Japanese,

Surgical cases for pulmonary artery aneurysm after palliative operation for congenital heart disease are rare. A man in his 40s underwent Waterston operation (side-side anastomosis of the ascending aorta and right pulmonary artery) for pulmonary atresia and ventricular septal defect at the age of one. Medical follow-up was continued at a local clinic without definitive repair. He had complained of exertional dyspnea and cough for one month. CT scan on admission showed a large right pulmonary artery aneurysm and atelectasis of the right lung. An urgent operation was planned for the huge pulmonary artery aneurysm. Under cardiac arrest, the proximal end-to-side anastomosis to the aorta was conducted using a Y-shaped vascular prosthesis at the previous Waterston anastomosis. The peripheral pulmonary arteries were reconstructed by inclusion technique. Percutaneous cardiopulmonary support was necessary for one day after operation due to unstable hemodynamics. He was extubated on postoperative day (POD) 4 and transferred to our general ward on POD 5. He was discharged home on POD 38. He is now free from heart failure symptoms and recurrence of aneurysm one year after surgery. Careful follow-up is necessary for the dilatation of the pulmonary artery and aortic root. A definitive operation—Rastelli and closure of the ventricular septal defect—may be considered in the future if the pulmonary artery resistance is suitable for the repair.

Ligation of Lumbar Arteries and Stent Graft-Conserving Aneurysmorrhaphy for Type II Endoleak
Sato Koji, Matsui Yoshiro, Shingu Yasushige, Wakasa Satoru, Kato Nobuyasu, Seki Tatsuya, Ooka Tomonori, Kato Hiroki, Tachibana Tsuyoshi, Kubota Suguru
Japanese Journal of Cardiovascular Surgery, 47, 6, 257, 262, The Japanese Society for Cardiovascular Surgery, 2018
Japanese,

Background : Persistent endoleak is a major cause of aneurysmal enlargement or rupture after endovascular aneurysm repair (EVAR). Although several reports have described ligation of lumbar arteries and stent graft-conserving aneurysmorrhaphy as useful strategies, treatment for type II endoleak after EVAR is controversial. Objectives : We investigated the early results in 5 patients who underwent ligation of lumbar arteries and stent graft-conserving aneurysmorrhaphy for type II endoleak. Methods : A>10 mm increase in aneurysm diameter after primary EVAR or a maximum diameter>65 mm serve as indications for intervention for type II endoleak. Under general anesthesia, following transperitoneal exposure of the abdominal aorta, the infrarenal aorta was banded using a tape at the proximal landing zone. After the aorta was opened without clamping, the lumbar arteries were ligated, and a stent graft-conserving aneurysmorrhaphy was performed. Results : The mean interval from the primary EVAR was 47±17 months. The mean operation time was 215±76 min. Blood transfusion was necessary in 4 patients (estimated blood loss 1,260±710 ml). No in-hospital deaths were observed, and the mean postoperative hospital stay was 26±20 days. One patient developed aspiration pneumonia and 1 developed surgical site infection post-surgery. The diameter of the aneurysm changed from 68±8 to 47±5 mm during hospitalization and decreased further to 36±7 mm at the last follow-up. Conclusions : The early results of ligation of lumbar arteries and stent graft-conserving aneurysmorrhaphy were favorable. Although this strategy could be useful for aneurysmal dilatation secondary to persistent type II endoleak after EVAR, the indications for this approach should be determined following careful evaluation of the patient's status considering the invasiveness of the procedure.

ランダム化比較試験後の腹部大動脈瘤破裂の課題 多施設共同研究　　　　　　　　　　　　　　　
佐藤 公治, 若狭 哲, 石橋 義光, 大川 洋平, 上久保 康弘, 須藤 幸雄, 牧野 裕, 松浦 弘司, 丸山 隆史, 村上 達哉, 本橋 雅壽, 山川 智士, 松居 喜郎
日本血管外科学会雑誌, 26, Suppl., O4, 4, (NPO)日本血管外科学会, Jun. 2017
Japanese

胸腹部大動脈瘤術後脊髄障害の発生におけるAdamkiewicz動脈開存性の意義　　　　　　　　　　　　　　　
若狭 哲, 佐藤 公治, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
日本外科学会定期学術集会抄録集, 117回, SF, 7, (一社)日本外科学会, Apr. 2017
Japanese

大動脈全弓部置換術における循環停止期間を予測する　　　　　　　　　　　　　　　
佐藤 公治, 若狭 哲, 浅井 英嗣, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
日本心臓血管外科学会学術総会抄録集, 47回, 420, 420, (NPO)日本心臓血管外科学会, Feb. 2017
Japanese

TypeIIエンドリークに対するステントグラフト温存直達手術　　　　　　　　　　　　　　　
佐藤 公治, 新宮 康栄, 浅井 英嗣, 太安 孝允, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
日本心臓血管外科学会学術総会抄録集, 47回, 872, 872, (NPO)日本心臓血管外科学会, Feb. 2017
Japanese

Optimal indication and limitation of surgical ventricular reconstruction for ischemic heart failure
Wakasa Satoru, Matsui Yoshiro, SURVIVE registry
Journal of the Japanese Coronary Association, 23, 2, 125, 129, The Japanese Coronary Association, 2017, [Invited], [Lead author]
Japanese

Left-Ventricular Plication Reduces Wall Stress and Cardiomyocyte Hypertrophy in a Rat Model of Ischemic Cardiomyopathy.
Hidetsugu Asai, Yasushige Shingu, Tomoji Yamakawa, Haruki Niwano, Satoru Wakasa, Tomonori Ooka, Hiroki Kato, Tsuyoshi Tachibana, Yoshiro Matsui
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 58, 1-2, 69, 80, 2017, [Peer-reviewed], [International Magazine]
English, BACKGROUND: The indications of left-ventricular plication (LVP) are controversial, although several studies have reported favorable outcomes in heart failure patients. The aim of this study was to assess left-ventricular (LV) wall stress and myocardial remodeling after LVP in a rat model of myocardial infarction (MI). METHODS: Sixteen rats underwent LVP by excluding the LV anterior wall scar 4 weeks after ligation of the left anterior descending artery. After 4 weeks, LV wall stress was assessed using transthoracic echocardiography and an LV catheter. Gene expression of the wall stress markers, atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP), were evaluated via reverse transcription polymerase chain reaction. Cardiomyocyte area and myocardial fibrosis were also examined through histological examinations. These parameters were compared to those in 16 rats that underwent coronary artery ligation but not LVP. RESULTS: We noted that the LV end-diastolic dimension was smaller (9.9 ± 0.3 vs. 11.2 ± 0.2 mm, p < 0.05) and fractional shortening was greater (25 ± 2 vs. 15 ± 1%, p < 0.05) in LVP rats than in sham rats. Moreover, systolic wall stress was lower in LVP rats (71 ± 7 vs. 111 ± 9 × 103 dyn/cm2, p < 0.05). Myocardial ANF and BNP expression levels were lower in LVP rats (2.6 ± 0.3 vs. 4.4 ± 0.5 and 1.0 ± 0.1 vs. 1.5 ± 0.2 arbitrary units, respectively; p < 0.05). Cardiomyocyte area was significantly decreased in LVP rats (556 ± 15 vs. 670 ± 28 μm2, p = 0.003) and was correlated with LV wall stress (r = 0.669, p = 0.002). The reduction in myocardial fibrosis after LVP was not significant. CONCLUSION: LVP reduced LV wall stress and cardiomyocyte hypertrophy in a rat model of MI.

Waterston手術後44年後に肺動脈瘤切迫破裂で発症したPA/VSDの1例
安東 悟央, 古川 夕里香, 村瀬 亮太, 杉本 聡, 佐藤 公治, 太安 孝允, 新宮 康栄, 若狭 哲, 加藤 裕貴, 大岡 智学, 橘 剛, 松居 喜郎
北海道外科雑誌, 61, 2, 197, 188, 北海道外科学会, Dec. 2016
Japanese

EVAR術後のsuprarenal stentに起因する仮性動脈瘤のため胸腹部大動脈置換術を要した1例　　　　　　　　　　　　　　　
佐藤 公治, 新宮 康栄, 古川 夕里香, 安東 悟央, 荒木 大, 杉本 聡, 村瀬 亮太, 浅井 英嗣, 太安 孝允, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
北海道外科雑誌, 61, 2, 188, 188, 北海道外科学会, Dec. 2016
Japanese

鬱血性肝障害を合併した心臓手術に対する手術成績
杉本 聡, 新宮 康栄, 村瀬 亮太, 佐藤 公治, 浅井 英嗣, 太安 孝允, 小林 一哉, 大岡 智学, 加藤 裕貴, 若狭 哲, 橘 剛, 松居 喜郎
北海道外科雑誌, 61, 1, 104, 105, 北海道外科学会, Jun. 2016
Japanese

企業製オープンステントグラフトの早期成績
佐藤 公治, 若狭 哲, 飯島 誠, 小林 一哉, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
北海道外科雑誌, 61, 1, 106, 106, 北海道外科学会, Jun. 2016
Japanese

破裂性腹部大動脈瘤に対する早期成績の検討
佐藤 公治, 若狭 哲, 石橋 義光, 大川 洋平, 大場 淳一, 上久保 康弘, 久保田 卓, 須藤 幸雄, 松浦 弘司, 丸山 隆史, 村上 達哉, 山川 智士, 松居 喜郎
日本血管外科学会雑誌, 25, Suppl., 179, 179, (NPO)日本血管外科学会, Jun. 2016
Japanese

Thoracoabdominal aortic aneurysm repair in the era of minimally invasive surgery
若狭 哲, 松居 喜郎
北海道外科雑誌 = The Hokkaido journal of surgery, 61, 1, 7, 12, 北海道外科学会, Jun. 2016, [Invited], [Lead author]
Japanese

Unicuspid Aortic Valve Stenosis Combined with Aortic Coarctation : Report of a Case
窪田武浩, 若狭哲, 新宮康栄, 松居喜郎
胸部外科, 69, 6, 467, 470, 南江堂, Jun. 2016, [Peer-reviewed]
Japanese

異種心膜パッチを用いたintervalvular fibrous body再建を要した弁手術の検討　　　　　　　　　　　　　　　
大岡 智学, 村瀬 亮太, 杉本 聡, 佐藤 公治, 浅井 英嗣, 飯島 誠, 小林 一哉, 新宮 康栄, 若狭 哲, 橘 剛, 松居 喜郎
日本外科学会定期学術集会抄録集, 116回, OP, 7, (一社)日本外科学会, Apr. 2016
Japanese

大動脈全弓部置換術成績向上の工夫 末梢吻合部位と循環停止時間短縮の観点から　　　　　　　　　　　　　　　
佐藤 公治, 若狭 哲, 飯島 誠, 小林 一哉, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
日本外科学会定期学術集会抄録集, 116回, PS, 1, (一社)日本外科学会, Apr. 2016
Japanese

The significance of the analysis on scalographic pattern for detecting malfunctioning bileaflet valve with the wavelet analysis.
Hiroshi Sugiki, Kenji Sugiki, Tomonori Ooka, Satoru Wakasa, Yasushige Shingu, Tsuyoshi Tachibana, Yoshiro Matsui
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 19, 1, 62, 9, Mar. 2016, [Peer-reviewed], [Domestic magazines]
English, The authors developed the wavelet analysis system which can detect the splitting of bileaflet mechanical heart valve (BLV) into two spikes on the scalogram, and reported that either consecutive single spike or the split behavior can detect malfunctioning BLV (MBV). The latest study on 12 BLVs suggested that the comparison between two spike areas showed higher potential to detect MBV than the split behavior. The aim of the current study is to review 226 files of BLV sound and to select the suitable scalographic property to differentiate the function of BLV with the split. Eight of 30 MBV files showed consecutive single spike, and the rest of 22 MBV files showed two spikes. Two spike areas can be compared by the following three ratios; the anterior spike area/posterior spike area (Aa/La), its reverse ratio (Pa/Aa) and the smaller spike area/the larger spike ratio (Sa/La). Therefore, the current study compared those three ratios to pursue the suitable ratio to compare two spike areas and its sensitivity to differentiate valve function by the ROC analysis. As a result, the Sa/La was suitable for comparing two spike areas, and only this ratio showed high accuracy to differentiate the function of BVL with the split, and its cutoff value was <0.665. Conclusively, the key for detecting MBV was either consecutive single spike or the mean of Sa/La < 0.665. However, this cutoff point is still tentative due to small number of malfunctioning valves, and other key might be available in future.

Modified Right Ventricular Obliteration Technique for Fontan Candidates with Non-functional Right Ventricle
Asai Hidetsugu, Tachibana Tsuyoshi, Shingu Yasushige, Wakasa Satoru, Oooka Tomonori, Matsui Yoshiro
Japanese Journal of Cardiovascular Surgery, 45, 1, 26, 31, The Japanese Society for Cardiovascular Surgery, 2016, [Peer-reviewed]
Japanese, Introduction : Right atrial (RA) and right ventricular (RV) dilatation that are associated with severe tricuspid regurgitation, and severe high RV pressure that is associated with pulmonary atresia and intact ventricular septum cause left ventricular (LV) dysfunction and hypoplastic lung. We have applied a modified RV obliteration technique that excludes non-functional enlarged RV for these diseases. Objectives : To evaluate the efficacy of our procedure. Methods and Results : Five patients (six operations) underwent the procedure without complications. Cardiothoracic ratio significantly decreased from 71±10% to 61±5% (p=0.017), and fractional shortening ended to increase from 27±17% to 37±5% (p=0.071). All of them achieved Fontan completion finally. One patient who underwent this procedure as a neonate experienced RV re-dilation 19 months later. He additionally received the same procedure in a Fontan operation, and then RV reduced again and good LV function was maintained. Conclusion : The application of modified RV obliteration technique is effective for Fontan candidates with nonfunctional RV.

3. Infective Endocarditis, 1) Surgical Intervention for Active Infective Endocarditis
Matsui Yoshiro, Wakasa Satoru, Ooka Tomonori, Shingu Yasushige
Nihon Naika Gakkai Zasshi, 105, 2, 238, 244, The Japanese Society of Internal Medicine, 2016, [Invited]
Japanese,

活動期感染性心内膜炎（infective endocarditis：IE）に対する外科治療は，心不全や感染の制御，塞栓症の予防の観点から，適応，手術時期を判断し，感染組織の可及的切除により再感染を予防する．また，脳合併症を呈する場合には，梗塞後出血や新規発症のリスクを考慮に入れたうえで適切な手術時期を決定すべきである．大動脈弁位では弁周囲膿瘍が起こりやすく，周囲組織との解剖学的関係を十分理解し，郭清，再建を行う．僧帽弁位では弁形成の可能性を常に考慮すべきである．

Treatment of Congenital Systemic and Coronary-to-Pulmonary Artery Fistulas
Kubota Takehiro, Wakasa Satoru, Shingu Yasushige, Matsui Yoshiro
Japanese Journal of Cardiovascular Surgery, 45, 4, 170, 175, The Japanese Society for Cardiovascular Surgery, 2016, [Peer-reviewed]
Japanese,

Congenital coronary artery-pulmonary artery fistula is rare and occurs concomitantly with various disease conditions, including myocardial ischemia symptoms and aneurisms. Such a fistula complicated by continuity to a systemic blood vessel is even rarer. The patient was a healthy 75-year-old man who had lost consciousness for several tens of seconds at home. An examination performed at a nearby neurosurgical clinic showed no abnormalities, and he was referred to our cardiovascular department for detailed examination for suspected cardiogenic syncope. Sick sinus syndrome was diagnosed based on Holter monitoring. Pulmonary artery-bilateral coronary artery fistula with coronary artery stenosis was diagnosed on coronary arteriography. It was difficult to determine whether coronary bypass surgery was indicated because of the presence of a fistula. Based on the overall evaluation of coronary fractional flow reserve, coronary artery ultrasound, and stress myocardial scintigraphy in addition to usual coronary arteriography, triple-vessel bypass surgery was indicated. Preoperative CT angiography showed a left common carotid artery/bronchial artery-pulmonary artery fistula, with a communication at a bilateral coronary artery-pulmonary artery fistula. Coronary artery bypass surgery was performed in addition to coronary artery-pulmonary artery fistula ligation, left common carotid artery-pulmonary artery fistula closure, bronchial artery-pulmonary artery fistula closure, and pacemaker implantation. Preoperative CT angiography and perioperative surface echocardiography were useful for locating fistula openings. The abnormal blood vessels that allowed blood flow from the left common carotid and bronchial arteries, and into the fistula vessel opening were ligated previously. When cardioplegic solution was injected, the fistula opening was directly pressed, which facilitated the solution to spread over the cardiac muscle, contributing to full cardiac arrest. Postoperative CT angiography showed disappearance of the pulmonary artery-bilateral coronary artery fistula and left common carotid artery/bronchial artery-pulmonary artery fistula. To our knowledge, there are no reports describing the surgical treatment of left common carotid artery/bronchial artery-pulmonary artery fistula and bilateral coronary artery-pulmonary artery fistula. Here we report this rare case with a review of the relevant literature.

下行大動脈置換時の再建肋間動脈開存性が次回胸腹部大動脈置換時の脊髄血流に与える影響
佐藤 公治, 若狭 哲, 浅井 英嗣, 太安 孝允, 小林 一哉, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
北海道外科雑誌, 60, 2, 204, 204, 北海道外科学会, Dec. 2015
Japanese

大動脈食道瘻の1治験例
杉本 聡, 村瀬 亮太, 佐藤 公治, 浅井 英嗣, 太安 孝允, 小林 一哉, 新宮 康栄, 大岡 智学, 加藤 裕貴, 若狭 哲, 橘 剛, 松居 喜郎
北海道外科雑誌, 60, 2, 204, 205, 北海道外科学会, Dec. 2015
Japanese

EVAR後のType Iaエンドリークに対して中枢側ネックbandingを施行した1例
村瀬 亮太, 新宮 康栄, 杉本 聡, 佐藤 公治, 浅井 英嗣, 太安 孝允, 小林 一哉, 大岡 智学, 加藤 裕貴, 若狭 哲, 橘 剛, 松居 喜郎
北海道外科雑誌, 60, 2, 206, 207, 北海道外科学会, Dec. 2015
Japanese

Can we treat DCM by surgical procedures?
松居喜郎, 若狭哲, 新宮康栄, 大岡智学, 橘剛
Heart view, 19, 10, 1146, 1152, メジカルビュー社, Oct. 2015, [Invited]
Japanese

Early Surgery for Active Infective Endocarditis
若狭哲, 松居喜郎
胸部外科, 68, 8, 586, 590, 20 Jul. 2015, [Invited], [Lead author]
Japanese

北大関連病院データベース(HOCARD)を用いた腹部大動脈瘤破裂の検討
佐藤 公治, 若狭 哲, 浅井 英嗣, 太安 孝允, 内藤 祐嗣, 小林 一哉, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
北海道外科雑誌, 60, 1, 77, 77, 北海道外科学会, Jun. 2015
Japanese

術後の創部感染におけるトリクロサン含有縫合糸の有用性
稗田 哲也, 佐藤 公治, 浅井 英嗣, 太安 孝允, 小林 一哉, 内藤 裕嗣, 新宮 康栄, 若狭 哲, 加藤 裕貴, 大岡 智学, 橘 剛, 松居 喜郎
北海道外科雑誌, 60, 1, 93, 93, 北海道外科学会, Jun. 2015
Japanese

Hydrofitを用いた大動脈吻合部出血軽減の工夫
若狭 哲, 内藤 祐嗣, 関 達也, 小林 一哉, 佐藤 公治, 新宮 康栄, 大岡 智学, 橘 剛, 松居 喜郎
日本血管外科学会雑誌, 24, 3, 349, 349, (NPO)日本血管外科学会, May 2015
Japanese

段階的胸腹部大動脈置換時の脊髄保護 胸部下行置換時の肋間動脈閉鎖が与える影響
佐藤 公治, 若狭 哲, 浅井 英嗣, 太安 孝允, 内藤 祐嗣, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
日本血管外科学会雑誌, 24, 3, 514, 514, (NPO)日本血管外科学会, May 2015
Japanese

心臓血管 末梢吻合部位の深さからみた遠位弓部大動脈瘤に対するstaged repair選択基準の検討　　　　　　　　　　　　　　　
佐藤 公治, 若狭 哲, 浅井 英嗣, 太安 孝允, 関 達也, 内藤 祐嗣, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
日本外科学会定期学術集会抄録集, 115回, OP, 4, (一社)日本外科学会, Apr. 2015
Japanese

Slope in preload recruitable stroke work relationship predicts survival after left ventriculoplasty and mitral repair in patients with idiopathic cardiomyopathy.
Yasushige Shingu, Suguru Kubota, Satoru Wakasa, Tomonori Ooka, Hiroki Kato, Tsuyoshi Tachibana, Yoshiro Matsui
Journal of cardiology, 65, 2, 157, 63, Feb. 2015, [Peer-reviewed], [International Magazine]
English, BACKGROUND: Left ventriculoplasty (LVP) and mitral valve plasty (MVP) are sometimes effective for patients with idiopathic dilated cardiomyopathy (DCM) who are not eligible for heart transplantation. Strict patient selection is warranted for these controversial procedures. METHODS AND RESULTS: The subjects were 18 patients with idiopathic DCM and mitral regurgitation who had not been indicated for heart transplantation due to either older age or patient refusal, and who underwent LVP and MVP. Their mean age was 57±14 years and 50% were dependent on catecholamine infusion. The preload recruitable stroke work (PRSW) relationship and its slope (Mw) were estimated by a single-beat technique using transthoracic echocardiography. There were one 30-day mortality and six (33%) hospital deaths due to heart failure. The one-year survival rate was 50%. Left ventricular end-diastolic dimension (LVDd) decreased from 77±11 to 68±11mm (p=0.001) whereas the ejection fraction did not change. Preoperative Mw was significantly higher in one-year survivors than that in non-survivors (54±17ergcm(-3)10(3) vs. 31±10ergcm(-3)10(3), p=0.005). Preoperative LVDd was not different between the groups. The cut-off value of 42ergcm(-3)10(3) for Mw predicted one-year survival with high sensitivity (100%) and specificity (77%). CONCLUSIONS: Mw, the slope in the PRSW relationship, may predict survival after LVP and MVP in patients with idiopathic DCM.

S字状心室中隔に伴う流出路狭窄による僧帽弁逆流と弁穿孔が溶血性貧血の原因となった僧帽弁形成術後の1例　　　　　　　　　　　　　　　
横山 しのぶ, 山田 聡, 新宮 康栄, 中鉢 雅大, 岩野 弘幸, 若狭 哲, 西田 睦, 渋谷 斉, 清水 力, 松居 喜郎
超音波医学, 42, 1, 84, 84, (公社)日本超音波医学会, Jan. 2015
Japanese

Characteristics of inoperable patients with severe aortic valve stenosis -in the era of transcatheter aortic valve replacement.
Tatsuya Seki, Mamoru Sakakibara, Yasushige Shingu, Hiroki Katoh, Satoru Wakasa, Hiroyuki Tsutsui, Yoshiro Matsui
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 21, 2, 132, 8, 2015, [Peer-reviewed], [Domestic magazines]
English, PURPOSE: Transcatheter aortic valve replacement (TAVR) has emerged as a therapeutic option for severe aortic valvular stenosis (AS). To determine the indication for TAVR, it is mandatory to clarify the characteristics of the patients who were judged as inoperable for conventional aortic valve replacement (cAVR). METHODS: Of 185 patients newly diagnosed as severe AS from March 2010 to April 2011, we studied the characteristics of 61 (33%) patients (mean age, 86 ± 8 years) who were judged as inoperable. RESULTS: Younger patients (<85 years old, n = 22) had more major comorbidities and lower left ventricular ejection fraction than older patients (≥85 years old, n = 39). Mean estimated mortality for cAVR by Japan score was 7.0% ± 7.4%. Japan score did not correlate to age and was calculated relatively low in the older age group (6.2% ± 7.0%) than the younger age group (8.3% ± 8.1%). CONCLUSION: One thirds of severe AS patients were judged as inoperable. In advanced age patients, age itself and other factors, which are not included in the conventional scoring systems, might have contributed to the decision making not to perform cAVR by cardiologists. Further study is necessary to define risk factors except for age.

Surgical strategy for ischemic mitral regurgitation adopting subvalvular and ventricular procedures.
Satoru Wakasa, Yasushige Shingu, Tomonori Ooka, Hiroki Katoh, Tsuyoshi Tachibana, Yoshiro Matsui
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 21, 4, 370, 7, 2015, [Peer-reviewed], [Lead author], [Domestic magazines]
English, PURPOSE: The progression of left ventricular (LV) remodeling and subsequent mitral valve tethering impair the results of reduction annuloplasty for ischemic mitral regurgitation (MR). METHODS: We studied 90 patients who underwent surgical repair of ischemic MR between 1999 and 2013 according to our surgical strategy adding submitral and ventricular procedures to annuloplasty as follows: annuloplasty alone (stage 1, n = 30), additional papillary muscle approximation (PMA) for progression of tethering (stage 2, n = 26), and additional left ventriculoplasty with PMA for progression of LV remodeling and tethering (stage 3, n = 34). RESULTS: The preoperative New York Heart Association (NYHA) functional classes (2.5 ± 0.7, 3.1 ± 0.7 and 3.3 ± 0.7 for stages 1, 2 and 3, respectively, P <0.001), LV end-diastolic diameters (56 ± 7 mm, 66 ± 5 mm and 70 ± 7 mm, P <0.001), and LV ejection fractions (45 ± 12%, 32 ± 9% and 27 ± 9%, P <0.001) significantly differed among the stages. In contrast, the MR grades did not significantly differ (2.9 ± 0.8, 3.0 ± 1.0, and 2.9 ± 1.1, respectively; P = 0.93). Both the rates of cardiac-related survival and freedom from reoperation were comparable among the 3 groups (log-rank P = 0.92 and 0.58, respectively). CONCLUSION: Additional submitral and ventricular procedures can compensate for the possible impairment of the outcomes after annuloplasty alone for ischemic MR in patients with severe LV remodeling and tethering.

Benefits of submitral procedures for ischemic mitral regurgitation.
Satoru Wakasa, Yoshiro Matsui
General thoracic and cardiovascular surgery, 62, 9, 511, 5, Sep. 2014, [Peer-reviewed], [Invited], [Lead author], [Domestic magazines]
English, The surgical strategy for ischemic mitral regurgitation (MR) remains controversial. Ischemic MR is a secondary valve disease caused by left ventricular (LV) remodeling and subsequent papillary muscle displacement, usually without structural valve lesions. Reduction annuloplasty is the standard surgical procedure for this condition, though it cannot clearly provide a survival benefit for those with LV dysfunction and is associated with a high prevalence of late recurrence of MR. The valvular procedure alone could be insufficient to treat ischemic MR in terms of long-term survival and the prevention of recurrence because ischemic MR is primarily a ventricular disorder. Thus, recent studies have focused on alternative procedures that target the primary cause of ischemic MR, the papillary muscles and left ventricle. We believe that the appropriate selection of surgical procedures among valvular, subvalvular, and even ventricular ones, considering the severity of LV remodeling for each patient would be more beneficial. Here we review recent studies featuring various surgical approaches to ischemic MR, especially with submitral procedures.

The extent of papillary muscle approximation affects mortality and durability of mitral valve repair for ischemic mitral regurgitation
Satoru Wakasa, Suguru Kubota, Yasushige Shingu, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui
JOURNAL OF CARDIOTHORACIC SURGERY, 9, 98, Jun. 2014, [Peer-reviewed], [Lead author]
English, Scientific journal

Risk scores for predicting mortality after surgical ventricular reconstruction for ischemic cardiomyopathy: Results of a Japanese multicenter study
Satoru Wakasa, Yoshiro Matsui, Tadashi Isomura, Shuichiro Takanashi, Atsushi Yamaguchi, Tatsuhiko Komiya, Yasunori Cho, Junjiro Kobayashi, Hitoshi Yaku, Kiyokazu Kokaji, Hirokuni Arai, Yoshiki Sawa
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 147, 6, 1868, U215, Jun. 2014, [Peer-reviewed], [Lead author]
English, Scientific journal

Consideration of optimal surgical strategy for aortoesophageal fistula
荒木大, 若狭哲, 久保田卓, 新宮康栄, 大岡智学, 橘剛, 松居喜郎
北海道外科雑誌, 59, 1, 37, 43, 北海道外科学会, Jun. 2014, [Peer-reviewed], [Corresponding author]
Japanese

Internal Cuff Reimplantation Technique for Aortic Branch Reconstruction
Satoru Wakasa, Yuji Naito, Suguru Kubota, Makoto Iijima, Yasushige Shingu, Yoshiro Matsui
ANNALS OF THORACIC SURGERY, 97, 5, 1822, 1823, May 2014, [Peer-reviewed], [Lead author]
English

Histological assessment of transmurality after repeated radiofrequency ablation of the left atrial wall
Satoru Wakasa, Suguru Kubota, Yasushige Shingu, Hiroki Kato, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui
General Thoracic and Cardiovascular Surgery, 62, 7, 428, 433, Springer-Verlag Tokyo, 2014, [Peer-reviewed], [Lead author]
English, Scientific journal

Surgical treatment for ischemic mitral regurgitation adopting submitral and ventricular procedures according to severity of left ventricular remodeling
Wakasa Satoru, Matsui Yoshiro
Journal of the Japanese Coronary Association, 20, 3, 255, 258, The Japanese Coronary Association, 2014, [Invited], [Lead author]
Japanese

Mitral valve surgery for ischemic mitral regurgitation with left ventricular dysfunction
Wakasa Satoru, Matsui Yoshiro
Journal of the Japanese Coronary Association, 20, 1, 84, 87, The Japanese Coronary Association, 2014, [Invited], [Lead author]
Japanese

Preoperative Regional Left Ventricular Wall Thickening Determined by Quantitative Gated SPECT as a Predictor of Mid-Term Surgical Results for Ischemic and Nonischemic Cardiomyopathy
Suguru Kubota, Satoru Wakasa, Yasushige Shingu, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui
CIRCULATION JOURNAL, 77, 12, 2936, 2941, Dec. 2013, [Peer-reviewed]
English, Scientific journal

One-stage radical operation of aortoesophageal fistula -combination of VATS esophagectomy and open aortic surgery : report of a case
Shichinohe Toshiaki, Wakasa Satoru, Kubota Suguru, Kato Kentaro, Ebihara Yuma, Kurashima Yo, Tsuchikawa Takahiro, Tanaka Eiichi, Matsui Yoshiro, Hirano Satoshi
Esophagus : official journal of the Japan Esophageal Society, 10, 4, 280, 284, Springer japan kk, Dec. 2013
English, Aortoesophageal fistula is a rare but fatal disease of thoracic surgery. We present a case of a 74-year-old male with aortoesophageal fistula. The patient underwent successful one-stage surgical treatment by video-assisted esophagectomy with esophageal reconstruction by gastric conduit and open aortic graft replacement subsequent to a temporary thoracic endovascular aortic repair.

Impact of left ventricular remodelling on outcomes after left ventriculoplasty for ischaemic cardiomyopathy: Japanese surgical ventricular reconstruction group experience(dagger)
Satoru Wakasa, Yoshiro Matsui, Tadashi Isomura, Shuichiro Takanashi, Atsushi Yamaguchi, Tatsuhiko Komiya, Yasunori Cho, Junjiro Kobayashi, Hitoshi Yaku, Kiyokazu Kokaji, Hirokuni Arai, Yoshiki Sawa
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 16, 6, 785, 791, Jun. 2013, [Peer-reviewed], [Lead author]
English, Scientific journal

Interrelation between myocardial oxidative metabolism and diastolic function in patients undergoing surgical ventricular reconstruction.
Satoru Chiba, Masanao Naya, Hiroyuki Iwano, Keiichiro Yoshinaga, Chietsugu Katoh, Osamu Manabe, Satoshi Yamada, Satoru Wakasa, Suguru Kubota, Yoshiro Matsui, Nagara Tamaki, Hiroyuki Tsutsui
European journal of nuclear medicine and molecular imaging, 40, 3, 349, 55, Feb. 2013, [Peer-reviewed], [International Magazine]
English, PURPOSE: Diastolic function is impaired in patients with end-stage heart failure. Favorable structural changes by surgical ventricular reconstruction (SVR) are thought to improve diastolic function, however, previous studies reported the contradictory results. We hypothesized that cardiac oxidative metabolism and diastolic dysfunction might improve in parallel to the reduction of left ventricular chamber size after SVR. METHODS: We studied 11 patients underwent SVR associated with mitral valve repair for end-stage heart failure due to dilated cardiomyopathy. Diastolic function was assessed by echocardiography and myocardial oxidative metabolism was measured by the monoexponential clearance (k-mono) of (11)C-acetate positron emission tomography at baseline and 1 month after SVR. RESULTS: All patients had preoperative severe diastolic dysfunction [E/A 4.11 ± 1.18, deceleration time (DT) 134 ± 26 ms]. The study patients were divided into 2 groups according to the changes in diastolic function after SVR; unchanged or worsened diastolic function in 6 patients (55 %, Non-responder) and improved diastolic function in 5 (45 %, Responder). K-mono and wall stress decreased only in responder. The changes in k-mono before and after SVR correlated with those in deceleration time (r =  -0.63; p < 0.05) and wall stress (r = 0.75; p < 0.01). CONCLUSIONS: Improvement of diastolic dysfunction in patients with end-stage heart failure by SVR was in parallel to that in oxidative metabolism. It suggests that SVR reduced excessive metabolism during the diastolic phase, in part, via the improvement in diastolic function and the reduction in LV wall stress.

Surgical strategy for aortoesophageal fistula in the endovascular era
Suguru Kubota, Norihiko Shiiya, Yasushige Shingu, Satoru Wakasa, Tomonori Ooka, Tsuyoshi Tachibana, Hidetoshi Yamauchi, Yoshimitu Ishibashi, Jun-Ichi Oba, Yoshiro Matsui
General Thoracic and Cardiovascular Surgery, 61, 10, 560, 564, 10, 2013, [Peer-reviewed]
English, Scientific journal

Diagnostic Value of Cytology of Pericardial Effusion for Cardiac Malignant Lymphoma
Asai Hidetsugu, Shingu Yasushige, Naito Yuji, Wakasa Satoru, Ōoka Tomonori, Tachibana Tsuyoshi, Kubota Suguru, Matsui Yoshiro
Japanese Journal of Cardiovascular Surgery, 42, 6, 494, 498, The Japanese Society for Cardiovascular Surgery, 2013
Japanese, Introduction : Although there are various diagnostic tools like computed tomography, magnetic resonance imaging, and positron emission tomography, it is sometimes difficult to precisely diagnose cardiac tumors. Early pathological diagnosis is crucial for possible chemotherapy and/or radiation therapy in cardiac malignant lymphoma. Objectives : To assess the diagnostic value of pericardial excisional biopsy and cytology of pericardial effusion for the pathological diagnosis of cardiac lymphoma. Methods : Five patients had a clinical diagnosis of cardiac tumor with no pathological diagnosis. The pericardial biopsy and pericardial effusion were obtained without sternotomy through the subxyphoid by a small incision under local anesthesia. Results : All procedures were completed without complications. In 3 cases, the cytology of pericardial effusion yielded a diagnosis of malignant lymphoma. One patient who had a negative cytology result in whom surgical resection was performed for definitive diagnosis and tumor volume reduction was found to have malignant lymphoma. The remaining patient underwent tumor biopsy via a cardiac catheter and benign lymphoma was diagnosed. There were no specific findings in the pericardial excisional biopsy in 3 cases. Conclusion : The analysis of cytology of pericardial effusion obtained through the subxyphoid may be useful for the diagnosis of cardiac malignant lymphoma. Pericardial excisional biopsy may not be necessary for the diagnosis of cardiac malignant lymphoma.

Optimal Indication for Surgical Ventricular Restoration for Dilated Cardiomyopathy
WAKASA SATORU, SHINGU YASUSHIGE, KUBOTA SUGURU, MINAMIDA TARO, IIJIMA MAKOTO, NAITO YUJI, OOKA TOMONORI, TACHIBANA TSUYOSHI, MATSUI YOSHIRO
胸部外科, 66, 1, 26, 30, 南江堂, Jan. 2013, [Invited], [Lead author]
Japanese

機能的僧帽弁逆流に対する前方への乳頭筋つり上げ術は左室流入血流障害を軽減する　　　　　　　　　　　　　　　
新宮 康栄, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎
北海道外科雑誌, 57, 2, 130, 134, 北海道外科学会, Dec. 2012, [Peer-reviewed]
Japanese

Postoperative atrial fibrillation: mechanism, prevention, and future perspective
Yasushige Shingu, Suguru Kubota, Satoru Wakasa, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui
SURGERY TODAY, 42, 9, 819, 824, Sep. 2012, [Peer-reviewed]
English

Surgical strategy for ischemic cardiomyopathy, including surgical ventricular reconstruction, ventricular assist device and heart transplantation
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎
Journal of the Japanese Coronary Association, 18, 3, 265, 269, The Japanese Coronary Association, 2012, [Invited]
Japanese

Surgical Ventricular Restoration Improves the Left Ventricle Basal Wall Function Using Quantitative Gated Spect
Suguru Kubota, Kinya Matsui, Satoru Wakasa, Yukio Suto, Shigeyuki Sasaki, Keiichiro Yoshinaga, Yoshiro Matsui
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, 17, 6, 552, 558, Dec. 2011, [Peer-reviewed]
English, Scientific journal

Analysis of the Risk Associated With Pregnancy in Women With Marfan Syndrome
Satoru Wakasa, Yoshiro Matsui
CIRCULATION JOURNAL, 75, 11, 2532, 2533, Nov. 2011, [Peer-reviewed], [Invited], [Lead author]
English

Surgical Ventricular Restoration for Ischemic Cardiomyopathy
WAKASA SATORU, SHINGU SUYASHIGE, OOKA TOMONORI, TACHIBANA TSUYOSHI, KUBOTA SUGURU, MATSUI YOSHIRO
胸部外科, 64, 11, 985, 988, 01 Oct. 2011, [Invited], [Lead author]
Japanese

Cytokine balance in hepatosplanchnic system during thoracoabdominal aortic aneurysm repair
Takashi Kunihara, Suguru Kubota, Norihiko Shiiya, Kenji Iizuka, Shigeyuki Sasaki, Satoru Wakasa, Kenji Matsuzaki, Yoshiro Matsui
JOURNAL OF ARTIFICIAL ORGANS, 14, 3, 192, 200, Sep. 2011, [Peer-reviewed]
English, Scientific journal

Measured Tube Technique for Ensuring the Correct Length of Slippery Artificial Chordae in Mitral Valvuloplasty
Yoshiro Matsui, Suguru Kubota, Hiroshi Sugiki, Satoshi Wakasa, Tomonori Ooka, Tsuyoshi Tachibana, Shigeyuki Sasaki
ANNALS OF THORACIC SURGERY, 92, 3, 1132, 1134, Sep. 2011, [Peer-reviewed]
English

Effects of surgical ventricular reconstruction and mitral complex reconstruction on cardiac oxidative metabolism and efficiency in nonischemic and ischemic dilated cardiomyopathy.
Takashi Sugiki, Masanao Naya, Osamu Manabe, Satoru Wakasa, Suguru Kubota, Satoru Chiba, Hiroyuki Iwano, Satoshi Yamada, Keiichiro Yoshinaga, Nagara Tamaki, Hiroyuki Tsutsui, Yoshiro Matsui
JACC. Cardiovascular imaging, 4, 7, 762, 70, 7, Jul. 2011, [Peer-reviewed], [International Magazine]
English, OBJECTIVES: The aim of this study was to investigate the effects of surgical ventricular reconstruction (SVR) on cardiac efficiency as a surrogate marker for cardiac function and oxidative metabolism in patients with severe heart failure. BACKGROUND: Our new integrated overlapping left ventriculoplasty, modified SVR, combined with mitral complex reconstruction, reduce left ventricular (LV) volume associated with improvement of symptoms of heart failure. METHODS: Twelve consecutive patients with end-stage heart failure due to nonischemic dilated cardiomyopathy (DCM) (n = 6) and ischemic dilated cardiomyopathy (ICM) (n = 6) who underwent SVR were studied. Myocardial oxidative metabolism per gram of tissue was estimated by monoexponential clearance of (11)C-acetate positron emission tomography (K(mono)). Forward stroke volume at the LV outflow tract was measured by echocardiography. Cardiac efficiency was estimated by the ratio of external work (stroke volume at the LV outflow tract index × systolic blood pressure × heart rate) to K(mono) before and 1 month after SVR. RESULTS: After SVR, medians of New York Heart Association functional class significantly improved from 3 to 1.5 (p < 0.01) in both DCM and ICM patients. End-systolic and end-diastolic volume and LV mass significantly decreased in both groups. Stroke volume at the LV outflow tract increased from 43 ± 8 ml to 52 ± 11 ml (p = 0.028) in DCM patients, but not in ICM patients (49 ± 21 ml to 59 ± 26 ml, p = 0.12). K(mono) × LV mass, as an index of global LV oxidative metabolism, decreased in DCM patients (13.6 ± 1.9 g/min vs. 8.6 ± 1.5 g/min, p = 0.03) and ICM patients (12.0 ± 3.4 g/min vs. 9.2 ± 1.0 g/min, p = 0.06). As a result, cardiac efficiency increased in all patients with DCM (3.34 ± 0.46 × 10E6 vs. 4.74 ± 0.88 × 10E6 mm Hg·ml·min/m(2), p = 0.03) and in 5 of 6 patients with ICM (4.54 ± 1.66 × 10E6 vs. 5.99 ± 2.11 × 10E6 mm Hg·ml·min/m(2), p = 0.12). CONCLUSIONS: Combined surgery with SVR and mitral complex reconstruction reduced LV volume in association with improvement of cardiac efficiency in patients with severe heart failure.

Can we change the operative criteria for the MAZE procedure combined with valve surgery in the era of radiofrequency devices?
Suguru Kubota, Hiroshi Sugiki, Satoru Wakasa, Tomonori Ooka, Tsuyoshi Tachibana, Shigeyuki Sasaki, Yoshiro Matsui
General Thoracic and Cardiovascular Surgery, 59, 6, 406, 412, 6, Jun. 2011, [Peer-reviewed]
English, Scientific journal

Successful excision of a saphenous vein graft aneurysm with different methods
Suguru Kubota, Satoru Wakasa, Tomonori Ooka, Tsuyoshi Tachibana, Shigeyuki Sasaki, Yoshiro Matsui
General Thoracic and Cardiovascular Surgery, 59, 6, 426, 428, 6, Jun. 2011, [Peer-reviewed]
English, Scientific journal

Left-ventricular electromechanical delay is prolonged in patients with postoperative atrial fibrillation
Yasushige Shingu, Suguru Kubota, Satoru Wakasa, Noriyoshi Ebuoka, Daisuke Mori, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 39, 5, 684, 688, May 2011, [Peer-reviewed]
English, Scientific journal

感染性大動脈瘤の診断におけるFDG-PETの有用性
飯島 誠, 浅井 英嗣, 澁谷 千英子, 加藤 伸康, 南田 太朗, 小林 一哉, 内藤 祐嗣, 夷岡 徳彦, 松井 欣哉, 若狭 哲, 杉木 宏司, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎
日本血管外科学会雑誌, 20, 2, 341, 341, (NPO)日本血管外科学会, Apr. 2011
Japanese

心大血管再手術80例の検討　　　　　　　　　　　　　　　
内藤 祐嗣, 夷岡 徳彦, 松井 欣哉, 若狭 哲, 杉木 宏司, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎
日本心臓血管外科学会雑誌, 40, Suppl., 328, 328, (NPO)日本心臓血管外科学会, Jan. 2011
Japanese

虚血性僧帽弁閉鎖不全症に対する乳頭筋接合術の成績　　　　　　　　　　　　　　　
若狭 哲, 杉木 宏司, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎
日本心臓血管外科学会雑誌, 40, Suppl., 363, 363, (NPO)日本心臓血管外科学会, Jan. 2011
Japanese

ウェーヴレット解析による新しい二葉弁機能不全診断基準の検討　　　　　　　　　　　　　　　
杉木 宏司, 久保田 卓, 大岡 智学, 橘 剛, 若狭 哲, 夷岡 徳彦, 松井 欣哉, 杉木 健司, 松居 喜郎
人工臓器, 39, 2, S148, S148, (一社)日本人工臓器学会, Nov. 2010
Japanese

心房内腫瘍栓を伴う肝細胞癌の4切除例　　　　　　　　　　　　　　　
大野 陽介, 神山 俊哉, 中西 一彰, 横尾 英樹, 蒲池 浩文, 田原 宗徳, 福森 大介, 松下 通明, 藤堂 省, 若狭 哲, 久保田 卓
北海道外科雑誌, 55, 1, 67, 67, 北海道外科学会, Jun. 2010
Japanese

A case of Carpentier-Edwards pericardial bioprosthesis in mitral position explanted 22 years after implantation
Suguru Kubota, Satoru Wakasa, Tomonori Ooka, Tsuyoshi Tachibana, Norihiko Shiiya, Yoshiro Matsui
JOURNAL OF ARTIFICIAL ORGANS, 13, 1, 48, 50, Apr. 2010, [Peer-reviewed]
English, Scientific journal

Anatomical Pattern of Feeding Artery and Mechanism of Intraoperative Spinal Cord Ischemia
Norihiko Shiiya, Satoru Wakasa, Kinya Matsui, Takashi Sugiki, Yasushige Shingu, Tomoshi Yamakawa, Yoshiro Matsui
ANNALS OF THORACIC SURGERY, 88, 3, 768, 772, Sep. 2009, [Peer-reviewed]
English, Scientific journal

成人重複大動脈弓の1例
阿部 慎司, 夷岡 徳彦, 新宮 康栄, 杉木 孝司, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 山川 智士, 椎谷 紀彦, 村下 十志文, 松居 喜郎
日本小児循環器学会雑誌, 25, 4, 638, 639, (NPO)日本小児循環器学会, Jul. 2009
Japanese

心臓腫瘍との鑑別に苦慮した冠動脈仮性瘤の1例　　　　　　　　　　　　　　　
太安 孝允, 加藤 伸康, 佐藤 公治, 夷岡 徳彦, 新宮 康栄, 杉木 孝司, 松井 欣哉, 若狭 哲, 大岡 智学, 橘 剛, 山川 智士, 久保田 卓, 椎谷 紀彦, 松居 喜郎, 大山 徳子, 筒井 裕之
北海道外科雑誌, 54, 1, 69, 70, 北海道外科学会, Jun. 2009
Japanese

Assessment of hepatosplanchnic pathophysiology during thoracoabdominal aortic aneurysm repair using visceral perfusion and shunt
Takashi Kunihara, Norihiko Shiiya, Satoru Wakasa, Kenji Matsuzaki, Yoshiro Matsui
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 35, 4, 677, 683, Apr. 2009, [Peer-reviewed]
English, Scientific journal

A semiquantitative analysis of reactive astrogliosis demonstrates its correlation with the number of intact motor neurons after transient spinal cord ischemia
Satoru Wakasa, Norihiko Shiiya, Tsuyoshi Tachibana, Tomonori Ooka, Yoshiro Matsui
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 137, 4, 983, 990, Apr. 2009, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Sivelestat Sodium is Effective to Prevent Acute Lung Injury in Acute Aortic Dissection
Yasushige Shingu, Norihiko Shiiya, Suguru Kubota, Yuji Naito, Kinya Matsui, Satoru Wakasa, Hiroshi Sugiki, Tsuyoshi Tachibana, Tomoji Yamakawa, Toshifumi Murashita, Yoshiro Matsui
ADVANCES IN UNDERSTANDING AORTIC DISEASES, 187, 187, 2009, [Peer-reviewed]
English, International conference proceedings

術後22年目に弁機能不全により再弁置換を行った僧帽弁位牛心膜生体弁の一例　　　　　　　　　　　　　　　
久保田 卓, 松居 喜郎, 佐藤 公治, 夷岡 徳彦, 新宮 康栄, 杉木 孝司, 若狭 哲, 大岡 智学, 橘 剛, 山川 智士, 椎谷 紀彦
人工臓器, 37, 2, S, 111, (一社)日本人工臓器学会, Nov. 2008
Japanese

Aortic Valve Replacement Through Left Thoracotomy After Esophageal Operation
Satoru Wakasa, Tomonori Ooka, Suguru Kubota, Norihiko Shiiya, Toshifumi Murashita, Yoshiro Matsui
ANNALS OF THORACIC SURGERY, 86, 5, 1668, 1670, Nov. 2008, [Peer-reviewed], [Lead author]
English

ステントグラフト導入後の腹部大動脈瘤手術　　　　　　　　　　　　　　　
佐藤 公治, 椎谷 紀彦, 若狭 哲, 杉木 孝司, 夷岡 徳彦, 松居 喜郎
日本血管外科学会雑誌, 17, 6, 656, 656, (NPO)日本血管外科学会, Oct. 2008
Japanese

Bulging sinusおよびePTFE弁付き導管を用いたRoss手術の治療経験
杉木 孝司, 村下 十志文, 若狭 哲, 杉木 宏司, 松居 喜郎
日本小児循環器学会雑誌, 24, 4, 564, 564, (NPO)日本小児循環器学会, Jul. 2008
Japanese

胸骨裏食道再建後の大動脈弁閉鎖不全症(AR)に対する左開胸での大動脈弁置換術の1例
若狭 哲, 阿部 慎司, 夷岡 徳彦, 内藤 祐嗣, 新宮 康栄, 松井 欣哉, 杉木 孝司, 大岡 智学, 橘 剛, 久保田 卓, 山川 智士, 椎谷 紀彦, 村下 十志文, 松居 喜郎
北海道外科雑誌, 53, 1, 116, 116, 北海道外科学会, Jun. 2008
Japanese

Microembolization from an Abdominal Aortic Aneurysm after Thoracic Aortic Replacement
Yasushige Shingu, Norihiko Shiiya, Takashi Sugiki, Satoru Wakasa, Kenji Matsuzaki, Takashi Kunihara, Yoshiro Matsui
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, 14, 2, 126, 128, Apr. 2008, [Peer-reviewed]
English, Scientific journal

遠隔期に再手術を要した人工弁周囲逆流症(PVL)の2例
夷岡 徳彦, 阿部 慎司, 内藤 祐嗣, 新宮 康栄, 松井 欣哉, 杉木 孝司, 若狭 哲, 杉木 宏司, 橘 剛, 久保田 卓, 山川 智士, 椎谷 紀彦, 村下 十志文, 松居 喜郎
北海道外科雑誌, 52, 2, 209, 209, 北海道外科学会, Dec. 2007
Japanese

Apicoaortic valved conduit for a patient with porcelain aorta and severe AS
杉木 孝司, 若狭 哲, 大岡 智学
北海道外科雑誌, 52, 2, 174, 177, 北海道外科学会, Dec. 2007, [Peer-reviewed]
Japanese

ウサギ脊髄虚血再灌流モデルにおける Astrocyte 活性化と遅発性運動神経細胞死に関する検討
若狭 哲
北海道醫學雜誌 = Acta medica Hokkaidonensia, 82, 6, 401, 408, 01 Nov. 2007, [Lead author, Corresponding author]
Japanese

開心術後のCEDV/RVEFモニタリングによる右室容量と中心静脈圧の変化　　　　　　　　　　　　　　　
新宮 康栄, 松井 欣哉, 杉木 孝司, 若狭 哲, 杉木 宏司, 橘 剛, 山川 智士, 久保田 卓, 椎谷 紀彦, 村下 十志文, 松居 喜郎
日本臨床外科学会雑誌, 68, 9, 2420, 2420, 日本臨床外科学会, Sep. 2007
Japanese

シャント閉鎖術後、自家静脈再建術後、再々発上腕動脈瘤の一例　　　　　　　　　　　　　　　
松井 欣哉, 椎谷 紀彦, 新宮 康栄, 杉木 孝, 若狭 哲, 杉木 宏司, 橘 剛, 山川 智士, 久保田 卓, 村下 十志文, 松居 喜郎
日本臨床外科学会雑誌, 68, 9, 2421, 2421, 日本臨床外科学会, Sep. 2007
Japanese

上行弓部大動脈置換術後における急性期心機能と脳性ナトリウム利尿ペプチド(BNP)　　　　　　　　　　　　　　　
新宮 康栄, 椎谷 紀彦, 阿部 慎司, 内藤 祐嗣, 松井 欣哉, 若狭 哲, 杉木 宏司, 橘 剛, 山川 智士, 久保田 卓, 村下 十志文, 松居 喜郎
脈管学, 47, Suppl., S128, S128, (一社)日本脈管学会, Sep. 2007
Japanese

心不全、不整脈に対する外科治療 重症心不全に対する左室形成術のpitfalls　　　　　　　　　　　　　　　
松居 喜郎, 杉木 宏司, 若狭 哲, 新宮 康栄, 久保田 卓, 椎谷 紀彦, 村下 十志文
日本外科系連合学会誌, 32, 3, 495, 495, 日本外科系連合学会, Jun. 2007
Japanese

高度石灰化を伴う腹部大動脈瘤に対し、瘤穿刺による中枢balloon occlusionを用いて手術を施行した1症例
松井 欣哉, 椎谷 紀彦, 松崎 賢司, 長谷川 公生, 杉木 孝司, 若狭 哲, 山下 知剛, 杉木 宏司, 国原 孝, 村下 十志文, 松居 喜郎
北海道外科雑誌, 52, 1, 77, 77, 北海道外科学会, Jun. 2007
Japanese

適応の破綻と修復 重症心不全に対する左室形成術による外科治療
松居 喜郎, 新宮 康栄, 若狭 哲, 杉木 宏司, 杉木 孝司, 松井 欣哉, 椎谷 紀彦, 村下 十志文
適応医学, 11, 1, 21, 21, 日本適応医学会, May 2007
Japanese

先天性僧帽弁閉鎖不全に対する弁形成手技とその成績
村下 十志文, 杉木 宏司, 若狭 哲, 松井 欣哉, 杉木 孝司, 椎谷 紀彦, 松居 喜郎
日本小児循環器学会雑誌, 23, 3, 279, 279, (NPO)日本小児循環器学会, May 2007
Japanese

Off-pump aortic arch repair through a median sternotomy for type b interrupted aortic arch with single ventricle physiology
Satoru Wakasa, Toshifumi Murashita, Takehiro Kubota, Hiroshi Sugiki
JOURNAL OF CARDIAC SURGERY, 22, 3, 215, 217, May 2007, [Peer-reviewed], [Lead author]
English, Scientific journal

拡張心に伴う機能的僧帽弁逆流に対する我々のmitral complex reconstruction法の効果　　　　　　　　　　　　　　　
松居 喜郎, 志村 信一郎, 須藤 幸雄, 深山 雅寿, 若狭 哲, 杉木 宏司, 国原 孝, 椎谷 紀彦, 村下 十志文
日本心臓血管外科学会雑誌, 36, Suppl., 222, 222, (NPO)日本心臓血管外科学会, Jan. 2007
Japanese

"Distal end-to-side first"法を用いたCrawford II型胸腹部大動脈置換術
椎谷 紀彦, 國原 孝, 松崎 賢司, 若狭 哲, 杉木 宏司, 松居 喜郎
The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 54, Suppl., 491, 491, (一社)日本胸部外科学会, Sep. 2006
Japanese

右側下行大動脈を伴った重複大動脈弓の1例　　　　　　　　　　　　　　　
杉木 宏司, 村下 十志文, 窪田 武浩, 若狭 哲, 椎谷 紀彦, 国原 孝, 松崎 賢司
The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 54, 5, 20, 20, (一社)日本胸部外科学会, May 2006
Japanese

僧帽弁形成術後の外科治療成績 中期遠隔期成績　　　　　　　　　　　　　　　
村下 十志文, 国原 孝, 杉木 宏司, 山下 知剛, 若狭 哲, 松崎 賢司, 窪田 武浩, 椎谷 紀彦
The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 54, 5, 25, 25, (一社)日本胸部外科学会, May 2006
Japanese

DICを併発したIEに対して両弁置換(ステントレス生体弁)を施行した一症例　　　　　　　　　　　　　　　
松井 欣哉, 村下 十志文, 国原 孝, 杉木 宏司, 若狭 哲, 松崎 賢司, 窪田 武浩, 椎谷 紀彦
The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 54, 5, 29, 29, (一社)日本胸部外科学会, May 2006
Japanese

TCPC術後ドレーン留置期間に関連する因子の検討
窪田 武浩, 若狭 哲, 杉木 宏司, 今村 道明, 村下 十志文, 安田 慶秀
日本小児循環器学会雑誌, 22, 1, 27, 27, (NPO)日本小児循環器学会, Jan. 2006
Japanese

外傷性末梢動脈疾患に対する手術の経験
若狭 哲, 新宮 康栄, 杉木 宏司, 菅 敏郎, 松崎 賢司, 國原 孝, 上久保 康弘, 椎谷 紀彦
北海道外科雑誌, 50, 2, 177, 177, 北海道外科学会, Dec. 2005
Japanese

肺動脈弁輪はどこまで温存可能か ファロー4徴症根治手術における弁輪温存手術
窪田 武浩, 若狭 哲, 杉木 宏司, 橘 剛, 村下 十志文, 安田 慶秀
The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 53, Suppl.II, 608, 608, (一社)日本胸部外科学会, Sep. 2005
Japanese

ファロー四徴症、両大血管右室起始症に対する根治術後に発生した肺動脈再狭窄の検討　　　　　　　　　　　　　　　
八田 英一郎, 若狭 哲, 杉木 宏司, 橘 剛, 窪田 武浩, 椎谷 紀彦, 村下 十志文, 安田 慶秀
日本心臓血管外科学会雑誌, 34, Suppl., 470, 470, (NPO)日本心臓血管外科学会, Jan. 2005
Japanese

Surgical Results of Takayasu's Arteritis
KUNIHARA Takashi, WAKASA Satoshi, MATSUZAKI Kenji, SHIIYA Norihiko, KUBOTA Takehiro, MURASHITA Toshifumi, YASUDA Keishu
脈管学, 44, 9, 363, 374, 25 Sep. 2004
Japanese

Modified B-T shunt術後人工血管由来のseromaと難治性胸水の治療に苦慮した1例
坂野 康人, 佐藤 一義, 若狭 哲, 衣川 佳数, 武田 充人, 山崎 弘州
道南医学会誌, 38, 38, 81, 83, 道南医学会, Jul. 2003
Japanese, 日齢6,女児.生直後よりチアノーゼを認め,NICUに搬送入院した.心エコー検査でエプスタイン奇形が認められた.機能的肺動脈弁閉鎖,肺血流量の減少,肺血流動脈管依存が認められた.挿管,人工呼吸管理を行ったが,状態の改善を認めず肺循環維持目的にB-Tシャント術を施行した.術後2日目,夜間に急激にLOSに陥った.レントゲン,超音波検査上,心嚢液貯留,心タンポナーデの所見で,緊急ドレナージ術を施行した.保存的治療では改善が見込めないため,再開胸止血術を施行した.手術後経過は良好で,術後の胸水殆ど認めず,術後5日目にドレーン抜去し,以後再貯留を認めなかった.現在,フォンタン型手術への待機中である

心不全で発症した Coronary-Subclavian Steal Syndrome の1症例
若狭哲
市立釧路医誌, 13, 94, 97, 2001, [Lead author]

デバイス関連感染性心内膜炎による慢性肺血栓塞栓症に対してハイブリッドアプローチでのデバイス全抜去を行った1例
田原就, 門坂崇秀, 佐々木颯, 上原拓樹, 島野金太郎, 川崎祐寛, 川上慧, 齋藤翔太, 西野広太郎, 甲谷次郎, 立田大志郎, 齋藤慈円, 南田太朗, 小西崇夫, 天満太郎, 永井利幸, 若狭哲, 安斉俊久, 植込みデバイス関連冬季大会プログラム・抄録集(Web), 17th, 2025

ラット心肺移植モデルでのAMI-Unloading後のオートファジー関連タンパク発現の検討
東亮太, コウ セイブン, 新宮康栄, 若狭哲, 日本心臓血管外科学会学術総会(Web), 55th, 2025

Frozen elephant trunk法を用いた全弓部置換術時の末梢吻合位置の検討
高柳涼, 杉木宏司, 加藤伸康, 南田大朗, 新宮康栄, 大岡智学, 若狭哲, 日本心臓血管外科学会学術総会(Web), 55th, 2025

植込型補助人工心臓ドライブライン感染症に対する統合的治療とその限界
大岡智学, 小熊宥統, 高柳涼, 砂土居泰生, 齊藤慈円, 東亮太, 南田大朗, 加藤伸康, 杉木宏司, 加藤裕貴, 新宮康栄, 若狭哲, 日本心臓血管外科学会学術総会(Web), 55th, 2025

EC-TCPC術中バソプレシン・アドレナリン投与と関連する術後経過変化の検討
小熊宥統, 齊藤慈円, 砂土居泰生, 加藤伸康, 高柳涼, 南田大朗, 杉木宏司, 新宮康栄, 加藤裕貴, 大岡智学, 若狭哲, 日本心臓血管外科学会学術総会(Web), 55th, 2025

RNAseq解析を用いたラット心筋梗塞後左室負荷軽減の影響の検討-炎症との関連
新宮康栄, 東亮太, コウ セイブン, 若狭哲, 日本心臓血管外科学会学術総会(Web), 55th, 2025

巨大左房に対する左房縫縮の手術成績の検討
南田大朗, 加藤伸康, 新宮康栄, 杉木宏司, 大岡智学, 若狭哲, 日本心臓血管外科学会学術総会(Web), 55th, 2025

冬眠動物と非冬眠動物の心臓冷却保存再灌流モデルにおけるミトコンドリア機能解析
コウ セイブン, 新宮康栄, 若狭哲, 日本心臓血管外科学会学術総会(Web), 55th, 2025

材料力学から検討する大血管の最適な吻合について
齊藤慈円, 新宮康栄, 若狭哲, 日本心臓血管外科学会学術総会(Web), 55th, 2025

当院における小児患者に対する開胸central ECMOの治療成績
加藤伸康, 南田大朗, 新宮康栄, 杉木宏司, 加藤裕貴, 大岡智学, 若狭哲, 人工心臓と補助循環懇話会学術集会プログラム・抄録集, 53rd (CD-ROM), 2025

自己肺動脈弁温存TOF手術の再介入に関する検討
加藤伸康, 砂土居泰生, 南田大朗, 杉木宏司, 大岡智学, 加藤裕貴, 新宮康栄, 山澤弘州, 武田充人, 若狭哲, 日本小児循環器学会総会・学術集会(Web), 61st, 2025

グラフト置換術後の人工血管劣化による出血に対しballoon expandable covered stentを用いて止血を得た症例
山崎康之, 木野田直也, 森田亮, 金谷本真, 藤井宝顕, 加藤大祐, 阿保大介, 斎藤慈円, 南田大朗, 若狭哲, 工藤與亮, 工藤與亮, 日本インターベンショナルラジオロジー学会雑誌(Web), 39, 3, 2025

Cardiac entrapment as a contraindication for minimally invasive mitral valve surgery under direct vision
新宮康栄, 若狭哲, 北海道外科雑誌, 70, 1, 2025

透析シャント肢の駆血による内胸動脈の血流変化に関する解析
齊藤慈円, 加藤伸康, 阿部慎司, 加藤裕貴, 大岡智学, 新宮康栄, 若狭哲, 日本心臓血管外科学会学術総会(Web), 54th, 2024

広範囲大動脈瘤に対する治療:Open Proximal Anastomosisにおける脳合併症の検証
齊藤慈円, 阿部慎司, 加藤伸康, 加藤裕貴, 大岡智学, 新宮康栄, 若狭哲, 日本血管外科学会雑誌(Web), 33, Supplement, 2024

透析シャント肢側の内胸動脈の血流解析
齊藤慈円, 加藤伸康, 杉木宏司, 新宮康栄, 大岡智学, 若狭哲, 日本冠疾患学会誌(Web), Supplement, 2024

当院におけるFROZENIXを用いたTAR-OSG後のDSINE発生症例についての検討
渡部克将, 佐藤公治, 若狭哲, 日本血管外科学会雑誌(Web), 33, Supplement, 2024

冠動脈バイパス術前の補助循環用ポンプカテーテル導入直後にショックバイタルとなった虚血性心疾患の一例
玉置陽生, 玉置陽生, 斉藤仁志, 下野裕依, 中村公亮, 石坂傑, 神谷究, 永井利幸, 南田大朗, 若狭哲, 安斉俊久, 日本集中治療医学会北海道支部学術集会プログラム・抄録集(Web), 8th, 2024

移植心冠動脈病変(CAV)の進行に近赤外線分光法血管内超音波(NIRS-IVUS)が有効であった1例
竹中秀, 佐藤琢真, 永井利幸, 神谷究, 小西崇夫, 内藤正一郎, 濱谷孟志, 森勇喜, 高橋昌寛, 若狭哲, 安斉俊久, 日本移植学会総会(Web), 60th, 2024

Treatment of Mitral Valve Infective Endocarditis in a Patient with Severe Metal Allergy: A Case Report
松井双葉, 齊藤慈円, 加藤伸康, 阿部慎司, 加藤裕貴, 大岡智学, 新宮康栄, 若狭哲, 北海道外科雑誌, 69, 1, 2024

4D-flowMRIを使用した奇静脈瘤術前の内部血流評価—Presurgical assessment of flow variability in an azygos vein aneurysm using 4D-flow MRI
幾島 拓也, 氏家 秀樹, 常田 慧徳, 千葉 龍平, 田畑 佑希子, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 加藤 達哉, 北海道外科雑誌 = The Hokkaido journal of surgery / 北海道外科雑誌編集委員会 編, 68, 1, 52, 54, Jun. 2023
[札幌] : 北海道外科学会, Japanese

IgG4関連冠動脈周囲炎に対する外科治療
齊藤慈円, 土田輝, 加藤伸康, 阿部慎司, 加藤裕貴, 大岡智学, 新宮康栄, 若狭哲, 日本冠疾患学会誌(Web), Supplement, 2023

ラット心筋細胞を用いた心停止ドナー冷却保存モデルにおけるトレハロース・プレコンディショニングの細胞生存率に対する影響
高せいぶん, 新宮康栄, 若狭哲, 日本移植学会総会(Web), 59th, 2023

B型解離に対するTEVAR術後遠隔期におけるRetrograde Type A Dissection
佐藤公治, 伊藤大貴, 杉木宏司, 久保田卓, 若狭哲, 日本血管外科学会雑誌(Web), 32, Supplement, 2023

植込型補助人工心臓治療におけるunmet medical needsの考察　　　　　　　　　　　　　　　
渡部 克将, 大岡 智学, 松本 嶺, 東 亮太, 須野 賢一郎, 稗田 哲也, 石垣 隆弘, 村瀬 亮太, 阿部 慎司, 加藤 伸康, 加藤 裕貴, 新宮 康栄, 若狭 哲, 北海道外科雑誌, 67, 1, 92, 92, Jun. 2022
北海道外科学会, Japanese

大動脈気管支瘻腸管瘻に対する治療 大動脈食道瘻に対する治療戦略 内視鏡手術を行う食道外科医の立場から　　　　　　　　　　　　　　　
七戸 俊明, 海老原 裕磨, 村上 壮一, 倉島 庸, 若狭 哲, 平野 聡, 日本外科学会定期学術集会抄録集, 122回, WS, 1, Apr. 2022
(一社)日本外科学会, Japanese

3D-バーチャル・リアリティー(VR)システムを用いた、呼吸器外科ロボット手術トレーニング法の開発　　　　　　　　　　　　　　　
氏家 秀樹, 幾島 拓也, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲, 日本外科学会定期学術集会抄録集, 122回, SF, 3, Apr. 2022
(一社)日本外科学会, Japanese

3D-バーチャル・リアリティー(VR)システムを用いた、呼吸器外科ロボット手術トレーニング法の開発　　　　　　　　　　　　　　　
氏家 秀樹, 幾島 拓也, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲, 日本外科学会定期学術集会抄録集, 122回, SF, 3, Apr. 2022
(一社)日本外科学会, Japanese

人工知能を用いた心大血管手術後長期リハビリ症例予測モデルの構築と検証　　　　　　　　　　　　　　　
村瀬 亮太, 新宮 康栄, 加藤 伸康, 加藤 裕貴, 大岡 智学, 若狭 哲, 日本臨床外科学会雑誌, 83, 3, 600, 600, Mar. 2022
日本臨床外科学会, Japanese

低左心機能に合併した機能性僧帽弁閉鎖不全症に対する治療-カテーテル治療(MitraClip、TMVR)と僧帽弁形成術、僧帽弁置換術 カテーテルインターベンション時代における機能性僧帽弁閉鎖不全症に対する治療選択肢の適切な準備(Proper Arrangement of Treatment Options for Functional Mitral Regurgitation in the Era of Catheter Mitral Intervention)　　　　　　　　　　　　　　　
若狭 哲, 日本循環器学会学術集会抄録集, 86回, SY13, 5, Mar. 2022
(一社)日本循環器学会, English

切除を先行した巨大(>10cm)肺腫瘤の2症例　　　　　　　　　　　　　　　
千葉 龍平, 加賀 基知三, 幾島 拓也, 田畑 佑希子, 藤原 晶, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 若狭 哲, 岡崎 ななせ, 若林 健人, 松野 吉宏, 肺癌, 62, 1, 72, 73, Feb. 2022
(NPO)日本肺癌学会, Japanese

化学放射線療法後の左主気管支腺様嚢胞癌の一手術例
幾島拓也, 氏家秀樹, 千葉龍平, 野村俊介, 田畑佑希子, 藤原晶, 樋田泰浩, 加賀基知三, 品川尚文, 高島雄太, 若狭哲, 松野吉宏, 加藤達哉, 日本胸部外科学会定期学術集会(Web), 75th, 2022

右主気管支狭窄に対し心膜吊り上げ法による縦隔授動とステント留置により救命し得た一例
長島諒太, 藤原晶, 千葉龍平, 田畑佑希子, 氏家秀樹, 加藤達哉, 樋田泰浩, 加賀基知三, 若狭哲, 品川尚文, 日本呼吸器外科学会総会(Web), 39th, 2022

ロボット支援下後縦隔腫瘍切除術における,腹臥位アプローチの有用性の検討
氏家秀樹, 海老原裕麿, 長島諒太, 千葉龍平, 野村俊介, 田畑祐希子, 藤原晶, 加藤達哉, 樋田泰浩, 加賀基知三, 若狭哲, 日本ロボット外科学会学術集会プログラム・抄録集, 14th, 2022

切除を先行した巨大(>10cm)肺腫瘤の2症例
千葉龍平, 加賀基知三, 幾島拓也, 田畑佑希子, 藤原晶, 氏家秀樹, 加藤達哉, 樋田泰浩, 若狭哲, 岡崎ななせ, 若林健人, 松野吉宏, 肺癌(Web), 62, 1, 2022

幼少期に留置した肺動脈ステント内狭窄に対する外科治療の経験　　　　　　　　　　　　　　　
加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲, 日本成人先天性心疾患学会雑誌, 11, 1, 195, 195, Jan. 2022
日本成人先天性心疾患学会, Japanese

難治性肺瘻をどう取り扱うか 肺切除後難治性肺瘻の治療戦略　　　　　　　　　　　　　　　
加賀 基知三, 樋田 泰浩, 加藤 達哉, 藤原 晶, 氏家 秀樹, 田畑 佑希子, 野村 俊介, 千葉 龍平, 幾島 拓也, 若狭 哲, 日本内視鏡外科学会雑誌, 26, 7, WS32, 3, Dec. 2021
(一社)日本内視鏡外科学会, Japanese

難治性肺瘻をどう取り扱うか 肺切除後難治性肺瘻の治療戦略　　　　　　　　　　　　　　　
加賀 基知三, 樋田 泰浩, 加藤 達哉, 藤原 晶, 氏家 秀樹, 田畑 佑希子, 野村 俊介, 千葉 龍平, 幾島 拓也, 若狭 哲, 日本内視鏡外科学会雑誌, 26, 7, WS32, 3, Dec. 2021
(一社)日本内視鏡外科学会, Japanese

有瘻性膿胸に対し気管支充填術と持続陰圧吸引療法を併用した2症例
田畑 佑希子, 加藤 達哉, 大塚 慎也, 幾島 拓也, 千葉 龍平, 藤原 晶, 氏家 秀樹, 樋田 泰浩, 品川 尚文, 有里 仁希, 高島 雄太, 加賀 基知三, 若狭 哲, 気管支学, 43, 6, 689, 689, Nov. 2021
(NPO)日本呼吸器内視鏡学会, Japanese

低左心機能を伴う虚血性閉鎖不全症〜外科手術vs Mitraclip〜 虚血性僧帽弁閉鎖不全症に対する外科治療戦略　　　　　　　　　　　　　　　
若狭 哲, 新宮 康栄, 加藤 伸康, 阿部 慎司, 大岡 智学, 松居 喜郎, 日本胸部外科学会定期学術集会, 74回, CWS2, 3, Oct. 2021
(一社)日本胸部外科学会, Japanese

混合型TAPVC術後の遺残病変修復に際して垂直静脈を遊離グラフトとして用いた1例　　　　　　　　　　　　　　　
渡部 克将, 加藤 伸康, 庭野 陽樹, 松本 嶺, 東 亮太, 須野 賢一郎, 石垣 隆弘, 稗田 哲也, 村瀬 亮太, 阿部 慎司, 新宮 康栄, 大岡 智学, 若狭 哲, 日本胸部外科学会定期学術集会, 74回, CCPA3, 8, Oct. 2021
(一社)日本胸部外科学会, Japanese

クロロキンの心筋虚血再灌流障害抑制効果の実験的検討　　　　　　　　　　　　　　　
村瀬 亮太, 新宮 康栄, 加藤 伸康, 加藤 裕貴, 大岡 智学, 若狭 哲, 日本胸部外科学会定期学術集会, 74回, COP35, 4, Oct. 2021
(一社)日本胸部外科学会, Japanese

非虚血性機能性僧帽弁閉鎖不全症に対する僧帽弁置換術において僧帽弁下手技によるアンチテザリング効果の追加が術後左室リバースリモデリングを誘導する　　　　　　　　　　　　　　　
石垣 隆弘, 若狭 哲, 新宮 康栄, 大川 洋平, 山田 陽, 松居 喜郎, 日本胸部外科学会定期学術集会, 74回, COP41, 4, Oct. 2021
(一社)日本胸部外科学会, Japanese

ECMO運用に関わる院内ガイドラインの作成　　　　　　　　　　　　　　　
藤原 晶, 若狭 哲, 大岡 智学, 斉藤 仁志, 新宮 康栄, 加賀 基知三, 太田 稔, 南須原 康行, 日本胸部外科学会定期学術集会, 74回, OD1, 1, Oct. 2021
(一社)日本胸部外科学会, Japanese

ファロー四徴症に対するValve slicingを用いた肺動脈弁温存の検討　　　　　　　　　　　　　　　
稗田 哲也, 加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲, 日本胸部外科学会定期学術集会, 74回, COD38, 3, Oct. 2021
(一社)日本胸部外科学会, Japanese

未来のための今 胸部外科医育成のための新たなる挑戦 3D-バーチャル・リアリティー(VR)システムを用いた、呼吸器外科手術トレーニング法の開発　　　　　　　　　　　　　　　
氏家 秀樹, 幾島 拓也, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲, 日本胸部外科学会定期学術集会, 74回, SP5, 3, Oct. 2021
(一社)日本胸部外科学会, Japanese

奇静脈瘤の伸展評価における4D-Flow MRIの有用性　　　　　　　　　　　　　　　
幾島 拓也, 氏家 秀樹, 加藤 達哉, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 日本胸部外科学会定期学術集会, 74回, LOD19, 5, Oct. 2021
(一社)日本胸部外科学会, Japanese

バーチャル・リアリティー(VR)システムを用いた,ロボット外科手術シミュレーション法の開発　　　　　　　　　　　　　　　
氏家 秀樹, 幾島 拓也, 千葉 龍平, 野村 俊介, 田畑 佑希子, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲, 肺癌, 61, 6, 613, 613, Oct. 2021
(NPO)日本肺癌学会, Japanese

COVID-19に対する、北海道大学の取り組み　　　　　　　　　　　　　　　
氏家 秀樹, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲, 石黒 信久, 豊嶋 崇徳, 日本呼吸器外科学会雑誌, 35, 3, SP2, 3, May 2021
(NPO)日本呼吸器外科学会, Japanese

小児に対するReduced port VATS　　　　　　　　　　　　　　　
加賀 基知三, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 氏家 秀樹, 藤原 晶, 加藤 達哉, 樋田 泰浩, 若狭 哲, 日本呼吸器外科学会雑誌, 35, 3, SP4, 6, May 2021
(NPO)日本呼吸器外科学会, Japanese

呼吸器外科におけるトランスレーショナルリサーチの最前線 ctDNAを用いた肺癌術後のMinimal residual diseaseモニタリングの有用性　　　　　　　　　　　　　　　
加藤 達哉, Low Siew-Kee, 清谷 一馬, 林 理絵, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 祐輔, 日本呼吸器外科学会雑誌, 35, 3, PD1, 5, May 2021
(NPO)日本呼吸器外科学会, Japanese

気管支充填術と分離陰圧閉鎖療法を併用した治療戦略　　　　　　　　　　　　　　　
大塚 慎也, 加藤 達哉, 千葉 龍平, 椎谷 洋彦, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 三浦 隆洋, 石川 耕資, 日本呼吸器外科学会雑誌, 35, 3, O14, 3, May 2021
(NPO)日本呼吸器外科学会, Japanese

通常採血管を用いたctDNA測定による肺癌術後モニタリングは術後早期再発検出に有用である　　　　　　　　　　　　　　　
加藤 達哉, Low Siew-Kee, 清谷 一馬, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 祐輔, 日本外科学会定期学術集会抄録集, 121回, SF, 2, Apr. 2021
(一社)日本外科学会, Japanese

通常採血管を用いたctDNA測定による肺癌術後モニタリングは術後早期再発検出に有用である　　　　　　　　　　　　　　　
加藤 達哉, Low Siew-Kee, 清谷 一馬, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 祐輔, 日本外科学会定期学術集会抄録集, 121回, SF, 2, Apr. 2021
(一社)日本外科学会, Japanese

重症虚血性僧帽弁閉鎖不全症に対する手術術式、乳頭筋介入に関する全国アンケート調査　　　　　　　　　　　　　　　
益澤 明広, 齊藤 翔吾, 有村 聡士, 高木 智充, 星野 理, 中尾 充貴, 松村 洋高, 儀武 路雄, 長堀 隆一, 坂東 興, 森田 紀代造, 荒井 裕国, 松宮 護郎, 高梨 秀一郎, 夜久 均, 小宮 達彦, 佐田 文宏, 松居 喜郎, 若狭 哲, 國原 孝, 日本心臓血管外科学会学術総会抄録集, 51回, OP15, 3, Feb. 2021
(NPO)日本心臓血管外科学会, Japanese

心室拡大による機能性僧帽弁閉鎖不全症の外科治療 左室リモデリングを中心に考える機能性僧帽弁閉鎖不全症に対する外科治療　　　　　　　　　　　　　　　
若狭 哲, 新宮 康栄, 石垣 隆弘, 加藤 伸康, 加藤 裕貴, 大岡 智学, 日本心臓血管外科学会学術総会抄録集, 51回, SY3, 4, Feb. 2021
(NPO)日本心臓血管外科学会, Japanese

ラット心筋虚血再灌流モデルにおけるトレハロース・プレコンディショニングの効果　　　　　　　　　　　　　　　
須野 賢一郎, 新宮 康栄, 安東 悟央, 若狭 哲, 日本心臓血管外科学会学術総会抄録集, 51回, OP13, 1, Feb. 2021
(NPO)日本心臓血管外科学会, Japanese

小児房室弁(単心室共通房室弁を含む)形成術 右側房室弁にEbstein病様の異形成を合併した共通房室弁閉鎖不全に対する弁形成　　　　　　　　　　　　　　　
加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲, 日本心臓血管外科学会学術総会抄録集, 51回, VS2, 4, Feb. 2021
(NPO)日本心臓血管外科学会, Japanese

重症虚血性僧帽弁閉鎖不全症に対する手術術式、乳頭筋介入に関する全国アンケート調査　　　　　　　　　　　　　　　
益澤 明広, 齊藤 翔吾, 有村 聡士, 高木 智充, 星野 理, 中尾 充貴, 松村 洋高, 儀武 路雄, 長堀 隆一, 坂東 興, 森田 紀代造, 荒井 裕国, 松宮 護郎, 高梨 秀一郎, 夜久 均, 小宮 達彦, 佐田 文宏, 松居 喜郎, 若狭 哲, 國原 孝, 日本心臓血管外科学会学術総会抄録集, 51回, OP15, 3, Feb. 2021
(NPO)日本心臓血管外科学会, Japanese

80歳以上高齢者の急性A型大動脈解離に対する外科手術のリスク因子解析　　　　　　　　　　　　　　　
石垣 隆弘, 新宮 康栄, 若狭 哲, 日本心臓血管外科学会学術総会抄録集, 51回, OP19, 4, Feb. 2021
(NPO)日本心臓血管外科学会, Japanese

Arterial switch operation後の死亡・再介入関連因子の検討　　　　　　　　　　　　　　　
稗田 哲也, 加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲, 日本心臓血管外科学会学術総会抄録集, 51回, OP28, 1, Feb. 2021
(NPO)日本心臓血管外科学会, Japanese

Frozen elephant trunk術後早期SINE発生のリスク因子　　　　　　　　　　　　　　　
佐藤 公治, 加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲, 日本心臓血管外科学会学術総会抄録集, 51回, OP32, 4, Feb. 2021
(NPO)日本心臓血管外科学会, Japanese

血気胸を発症したPleuroparenchymal fibroelastosis(PPFE)合併肺癌の1切除例
大塚 慎也, 加藤 達哉, 佐々木 明洋, 山崎 洋, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 順一, 篠崎 鮎香, 中久保 祥, 木村 孔一, 渡辺 正明, 岡崎 ななせ, 松野 吉宏, 肺癌, 61, 1, 67, 67, Feb. 2021
(NPO)日本肺癌学会, Japanese

血気胸を発症したPleuroparenchymal fibroelastosis(PPFE)合併肺癌の1切除例
大塚 慎也, 加藤 達哉, 佐々木 明洋, 山崎 洋, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 順一, 篠崎 鮎香, 中久保 祥, 木村 孔一, 渡辺 正明, 岡崎 ななせ, 松野 吉宏, 肺癌, 61, 1, 67, 67, Feb. 2021
(NPO)日本肺癌学会, Japanese

神経線維腫症I型に肺腺癌、内頸動静脈瘻を合併した1例
横山 誓也, 氏家 秀樹, 加藤 達哉, 大塚 慎也, 佐々木 明洋, 山崎 洋, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 松野 吉宏, 今井 陽子, 肺癌, 61, 1, 67, 68, Feb. 2021
(NPO)日本肺癌学会, Japanese

日本のHeart Allocation Systemには,日本のエビデンスに基づいたIncentivesの導入が必要である
大岡智学, 櫛引勝年, 加藤美香, 加藤伸康, 加藤裕貴, 新宮康栄, 若狭哲, 日本移植学会総会(Web), 57th, 2021

Prediction of Pulmonary Embolism Following Resection of Pulmonary Infarction: A Case Series
Yamasaki Hiroshi, Ujiie Hideki, Kato Tatsuya, Hida Yasuhiro, Kaga Kichizo, Wakasa Satoru, Matsuno Yoshihiro, Annals of Thoracic and Cardiovascular Surgery (Web), 27, 6, 2021

肝移植後にPleuroparenchymal fibroelastosis(PPFE)合併肺癌を発症した一例
大塚慎也, 加藤達哉, 氏家秀樹, 椎谷洋彦, 加賀基知三, 若狭哲, 中村順一, 中久保祥, 木村孔一, 渡辺正明, 嶋村剛, 岡崎ななせ, 松野吉宏, 田中敏, 日本移植学会総会プログラム抄録集, 57th (Web), 2021

胎児治療を施行したCongenital pulmonary airway malformation(CPAM)の患児に対し日齢9で完全胸腔鏡下右上葉切除術を施行した一例
幾島拓也, 氏家秀樹, 加藤達哉, 大塚慎也, 千葉龍平, 野村俊介, 椎谷洋彦, 田畑佑希子, 藤原晶, 樋田泰浩, 加賀基知三, 若狭哲, 本多昌平, 日本気胸・嚢胞性肺疾患学会雑誌, 21, 2, 2021

肺切除後難治性肺ろうの治療戦略
加賀基知三, 樋田泰浩, 加藤達哉, 藤原晶, 氏家秀樹, 田畑佑希子, 野村俊介, 千葉龍平, 幾島拓也, 若狭哲, 日本内視鏡外科学会総会(Web), 34th, 2021

神経線維腫症I型に肺腺癌,内頚動静脈瘻を合併した1例
横山誓也, 氏家秀樹, 加藤達哉, 大塚慎也, 佐々木明洋, 山崎洋, 藤原晶, 樋田泰浩, 加賀基知三, 若狭哲, 松野吉宏, 今井陽子, 肺癌(Web), 61, 1, 2021

血気胸を発症したPleuroparenchymal fibroelastosis(PPFE)合併肺癌の1切除例
大塚慎也, 加藤達哉, 佐々木明洋, 山崎洋, 氏家秀樹, 藤原晶, 樋田泰浩, 加賀基知三, 若狭哲, 中村順一, 篠崎鮎香, 中久保祥, 木村孔一, 渡辺正明, 岡崎ななせ, 松野吉宏, 肺癌(Web), 61, 1, 2021

バーチャル・リアリティー(VR)システムを用いた,呼吸器外科手術シミュレーション法の開発
氏家秀樹, 大塚慎也, 千葉龍平, 椎谷洋彦, 藤原晶, 加藤達哉, 樋田泰浩, 加賀基知三, 若狭哲, 気管支学, 43, 2021

肺移植後に発症したα-グルコシダーゼ阻害薬内服中の腸管嚢胞様気腫症の一例
大塚慎也, 大塚慎也, 氏家秀樹, 加藤達哉, 千葉龍平, 椎谷洋彦, 藤原晶, 樋田泰浩, 加賀基知三, 若狭哲, 井上玲, 飯村泰昭, 日本肺および心肺移植研究会プログラム・抄録集, 37th, 2021

80歳以上高齢者の急性A型大動脈解離に対する外科手術のリスク因子解析　　　　　　　　　　　　　　　
石垣 隆弘, 新宮 康栄, 若狭 哲, HOCARD members, 日本血管外科学会雑誌, 30, Suppl., O11, 1, 2021
(NPO)日本血管外科学会, Japanese

Frozen elephant trunk術後dSINEリスクの検討　　　　　　　　　　　　　　　
佐藤 公治, 加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲, 日本血管外科学会雑誌, 30, Suppl., O24, 1, 2021
(NPO)日本血管外科学会, Japanese

止血デバイスを用いた経皮的腹部ステントグラフト内挿術の創合併症予防効果の検討　　　　　　　　　　　　　　　
鍋島 龍一, 石垣 隆弘, 加藤 伸康, 加藤 裕貴, 新宮 康栄, 大岡 智学, 若狭 哲, 日本血管外科学会雑誌, 30, Suppl., O37, 1, 2021
(NPO)日本血管外科学会, Japanese

二心室修復可能な心疾患に対する姑息的右室流出路再建術8例の検討　　　　　　　　　　　　　　　
加藤 伸康, 橘 剛, 新宮 康栄, 若狭 哲, 加藤 裕貴, 大岡 智学, 山澤 弘州, 武田 充人, 日本小児循環器学会雑誌, 36, Suppl.2, s2, 383, Nov. 2020
(NPO)日本小児循環器学会, Japanese

透析患者における3年間のデノスマブ投与の効果　　　　　　　　　　　　　　　
伊藤 賀恵, 熊田 千晶, 飯塚 一秀, 永井 志保, 永井 哲士, 関口 孝, 中島 豊, 衣笠 えり子, 若狭 幹雄, 宍戸 寛治, 日本透析医学会雑誌, 53, Suppl.1, 553, 553, Oct. 2020
(一社)日本透析医学会, Japanese

肺移植患者における超音波気管支鏡の安全性および有効性の検討
氏家 秀樹, 加藤 達哉, 稲毛 輝長, 石綿 司, 新垣 雅人, 樋田 泰浩, 加賀 基知三, 若狭 哲, Keshavjee Shaf, Yasufuku Kazuhiro, 移植, 55, 総会臨時, 383, 383, Oct. 2020
(一社)日本移植学会, Japanese

感染症対策を見据えたVAD治療の進歩と臨床展開 VAD関連感染症の治療戦略 大網と局所閉鎖陰圧療法の適用と有効性　　　　　　　　　　　　　　　
大岡 智学, 布施川 真哲, 鍋島 龍二, 小市 裕太, 稗田 哲也, 石垣 隆弘, 佐藤 公治, 加藤 伸康, 新宮 康栄, 若狭 哲, 人工臓器, 49, 2, S, 53, Oct. 2020
(一社)日本人工臓器学会, Japanese

非典型的な先天性嚢胞性肺疾患　　　　　　　　　　　　　　　
加賀 基知三, 大塚 慎也, 佐々木 明洋, 山崎 洋, 氏家 秀樹, 藤原 晶[黒田], 加藤 達哉, 樋田 泰浩, 若狭 哲, 日本気胸・嚢胞性肺疾患学会雑誌, 20, 1, 69, 69, Aug. 2020
日本気胸・嚢胞性肺疾患学会, Japanese

智と技の伝承(鏡視外科手術トレーニングの将来像) ドライラボ、カダバーを用いた単孔式胸腔鏡手術(Uniportal VATS)トレーニングの経験
藤原 晶, 大塚 慎也, 山崎 洋, 佐々木 明洋, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲, 小切開・鏡視外科学会雑誌, 11, 1, 38, 38, Jun. 2020
(NPO)小切開・鏡視外科学会, Japanese

先天性肺嚢胞性疾患に対する胸腔鏡手術の適応と成績
加賀 基知三, 大塚 慎也, 佐々木 明洋, 山崎 洋, 氏家 秀樹, 藤原 晶[黒田], 加藤 達哉, 樋田 泰浩, 若狭 哲, 小切開・鏡視外科学会雑誌, 11, 1, 50, 50, Jun. 2020
(NPO)小切開・鏡視外科学会, Japanese

有茎肋間筋弁による胸腔鏡下気管支断端被覆の検討
山崎 洋, 加賀 基知三, 大塚 慎也, 佐々木 明洋, 氏家 秀樹, 藤原 晶, 加藤 達也, 樋田 泰浩, 若狭 哲, 小切開・鏡視外科学会雑誌, 11, 1, 57, 57, Jun. 2020
(NPO)小切開・鏡視外科学会, Japanese

【小児の先天性嚢胞性肺疾患に対する胸腔鏡手術】
加賀 基知三, 樋田 泰浩, 加藤 達哉, 藤原 晶[黒田], 椎名 伸行, 氏家 秀樹, 佐々木 明洋, 山崎 洋, 若狭 哲, 北海道外科雑誌, 65, 1, 2, 7, Jun. 2020
北海道外科学会, Japanese

Type IIエンドリークに対する腰動脈結紮・ステントグラフト温存瘤縫縮術　　　　　　　　　　　　　　　
小市 裕太, 新宮 康栄, 新井 洋輔, 石垣 隆弘, 安東 悟央, 稗田 哲也, 佐藤 公治, 加藤 伸康, 関 達也, 加藤 裕貴, 若狭 哲, 大岡 智学, 日本インターベンショナルラジオロジー学会雑誌, 34, 4, 298, 298, Apr. 2020
(一社)日本インターベンショナルラジオロジー学会, Japanese

VISUALIZATION OF PERIPROCEDUAL BLOOD FLOW DYNAMICS WITH FOUR-DIMENSIONAL FLOW MAGNETIC RESONANCE IMAGING IN PATIENTS WITH SEVERE AORTIC STENOSIS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT
Hirokazu Komoriyama, Kiwamu Kamiya, Toshiyuki Nagai, Noriko Oyama-Manabe, Satonori Tsuneta, Yuta Kobayashi, Yoshiya Kato, Kazunori Omote, Takao Konishi, Takuma Sato, Shingo Tsujinaga, Hiroyuki Iwano, Yasushige Shingu, Satoru Wakasa, Toshihisa Anzai, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 75, 11, 1639, 1639, Mar. 2020
English, Summary international conference

心筋症に対する外科的左室負荷軽減と「アジュバント治療」の可能性　　　　　　　　　　　　　　　
新宮 康栄, 稗田 哲也, 加藤 伸康, 若狭 哲, 大岡 智学, 日本心臓血管外科学会学術総会抄録集, 50回, PR20, 1, Mar. 2020
(NPO)日本心臓血管外科学会, Japanese

機能性僧帽弁逆流に対する置換術式による左室内エネルギー損失の違い VFMによる検討　　　　　　　　　　　　　　　
石垣 隆弘, 新宮 康栄, 加藤 伸康, 若狭 哲, 大岡 智学, 大川 洋平, 山田 陽, 高橋 順一郎, 松居 喜郎, 日本心臓血管外科学会学術総会抄録集, 50回, O9, 1, Mar. 2020
(NPO)日本心臓血管外科学会, Japanese

肺動脈血栓内膜摘除は慢性血栓塞栓性肺高血圧症に対する標準治療であり続けられるか?　　　　　　　　　　　　　　　
大岡 智学, 小市 裕太, 稗田 哲也, 荒木 大, 石垣 隆弘, 安東 悟央, 佐藤 公治, 加藤 伸康, 新宮 康栄, 若狭 哲, 加藤 裕貴, 日本心臓血管外科学会学術総会抄録集, 50回, O11, 4, Mar. 2020
(NPO)日本心臓血管外科学会, Japanese

当院における完全型房室中隔欠損症に対する二心室修復の成績　　　　　　　　　　　　　　　
稗田 哲也, 加藤 伸康, 小市 裕太, 安東 悟央, 荒木 大, 石垣 隆弘, 佐藤 公治, 新宮 康栄, 若狭 哲, 加藤 裕貴, 大岡 智学, 橘 剛, 日本心臓血管外科学会学術総会抄録集, 50回, P2, 3, Mar. 2020
(NPO)日本心臓血管外科学会, Japanese

胸腹部大動脈瘤手術時の肋間動脈再建法の工夫と脊髄保護-internal cuff reimplantation法の有用性
佐藤公治, 杉本聡, 加藤伸康, 新宮康栄, 杉木宏司, 加藤裕貴, 大岡智学, 若狭哲, 日本胸部外科学会定期学術集会(Web), 73rd, 2020

Midterm results of stent graft-conserving aneurysmorrhaphy
佐藤公治, 若狭哲, 新宮康栄, 杉木宏司, 加藤裕貴, 大岡智学, 日本血管外科学会雑誌(Web), 29, Supplement, 2020

肺移植患者における超音波気管支鏡の安全性および有効性の検討
氏家 秀樹, 加藤 達哉, 稲毛 輝長, 石綿 司, 新垣 雅人, 樋田 泰浩, 加賀 基知三, 若狭 哲, 移植, 55, Supplement, 383_2, 383_2, 2020
目的 気管支腔内超音波検査法（EBUS）は低侵襲かつ高い診断能を有する検査手技である。本研究では、肺移植待機患者および移植後患者の経過中に、悪性腫瘍が疑われた肺・リンパ節病変に対するEBUSの有用性を検討した。方法 2008年～2018年までの間にEBUSガイド下経気道的肺生検 (EBUS-GS-TBB, EBUS-TBNA)が施行された肺移植後患者及び待機患者に対し後方視的検討を行った。結果 全28例に対してEBUS-TBNA：20例、EBUS-GS-TBB：8例 が施行された。肺移植術後患者19例の内訳は、移植後に肺腫瘤を認め悪性腫瘍が疑われた11例、肺門及び縦隔リンパ節腫大を認め移植後リンパ増殖性疾患(PTLD)が疑われた8例であった。全症例において確定診断が可能であり、重篤な合併症を認めなかった。診断の内訳は、原発性肺癌6例、PTLD 4例、感染性疾患3例、良性疾患6例であった。PTLDが疑われた8例中、4例（50%）がPTLDと診断され、肺悪性腫瘍が疑われた11例中、6例(55%)で肺悪性腫瘍の確定診断が可能であった。また、肺移植待機9例のうち、5例（56%）にて肺悪性腫瘍の確定診断に至り、治療方針が変更された。結論 移植待機中の末期慢性肺疾患症例及び肺移植術前後症例におけるEBUSは、肺病変及び縦隔肺門リンパ節に対する安全かつ高精度な質的診断が可能な検査法と考えられた。, 一般社団法人 日本移植学会, Japanese

ヘッドマウントディスプレイ(HMD)によるバーチャル・リアリティー(VR)システムを用いた,肺区域切除手術シミュレーション法の開発
氏家秀樹, 大塚慎也, 佐々木明洋, 山崎洋, 藤原晶, 加藤達哉, 樋田泰浩, 加賀基知三, 若狭哲, 日本胸部外科学会定期学術集会(Web), 73rd, 2020

気管ステント留置後の逸脱に対し気管形成術を行い救命できた外傷性気管損傷の一例
大塚慎也, 加藤達哉, 氏家秀樹, 山崎洋, 佐々木明洋, 藤原晶, 樋田泰浩, 加賀基知三, 若狭哲, 高島雄太, 品川尚文, 日本胸部外科学会定期学術集会(Web), 73rd, 2020

肉眼的に乳頭状線維弾性腫と鑑別が困難であったvilloustype左房粘液腫の1例
石垣 隆弘, 新宮 康栄, 加藤 伸康, 若狭 哲, 大岡 智学, 加藤 裕貴, 若林 健人, 三橋 智子, 松居 喜郎, 北海道外科雑誌, 64, 2, 207, 207, Dec. 2019
北海道外科学会, Japanese

カルニチンによる心臓弁膜症手術後の心房細動の予防(単群介入試験)
新宮 康栄, 小市 裕太, 稗田 哲也, 新井 洋輔, 安東 悟央, 石垣 隆弘, 佐藤 公治, 加藤 伸康, 若狭 哲, 大岡 智学, 北海道外科雑誌, 64, 2, 209, 209, Dec. 2019
北海道外科学会, Japanese

川崎病冠動脈障害に対する冠動脈バイパス術　　　　　　　　　　　　　　　
安東 悟央, 若狭 哲, 加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 日本冠疾患学会誌, Suppl.2019, 179, 179, Dec. 2019
(NPO)日本冠疾患学会, Japanese

肉眼的に乳頭状線維弾性腫と鑑別が困難であったvilloustype左房粘液腫の1例　　　　　　　　　　　　　　　
石垣 隆弘, 新宮 康栄, 加藤 伸康, 若狭 哲, 大岡 智学, 加藤 裕貴, 若林 健人, 三橋 智子, 松居 喜郎, 北海道外科雑誌, 64, 2, 207, 207, Dec. 2019
北海道外科学会, Japanese

カルニチンによる心臓弁膜症手術後の心房細動の予防(単群介入試験)　　　　　　　　　　　　　　　
新宮 康栄, 小市 裕太, 稗田 哲也, 新井 洋輔, 安東 悟央, 石垣 隆弘, 佐藤 公治, 加藤 伸康, 若狭 哲, 大岡 智学, 北海道外科雑誌, 64, 2, 209, 209, Dec. 2019
北海道外科学会, Japanese

長期(3年以上)VAD治療の課題と対策 長期植込型補助人工心臓治療の現状、課題、そして対策　　　　　　　　　　　　　　　
大岡 智学, 加藤 伸康, 新宮 康栄, 若狭 哲, 加藤 裕貴, 松居 喜朗, 寒河江 磨, 矢萩 亮児, 櫛引 勝年, 加藤 美香, 人工臓器, 48, 2, S, 75, Oct. 2019
(一社)日本人工臓器学会, Japanese

感染性大動脈瘤に対するウシ心膜ロールを用いた人工血管置換症例の検討　　　　　　　　　　　　　　　
関 達也, 松居 喜郎, 新宮 康栄, 大岡 智学, 若狭 哲, 脈管学, 59, Suppl., S231, S231, Oct. 2019
(一社)日本脈管学会, Japanese

原発性肺動脈腫瘍に対する治療経験　　　　　　　　　　　　　　　
安東 悟央, 大岡 智学, 小市 裕太, 新井 洋輔, 稗田 哲也, 石垣 隆弘, 佐藤 公治, 関 達也, 新宮 康栄, 若狭 哲, 加藤 裕貴, 脈管学, 59, Suppl., S288, S288, Oct. 2019
(一社)日本脈管学会, Japanese

卵円孔開存の判断に苦慮した心房内血栓症の一症例　　　　　　　　　　　　　　　
佐藤 文昭, 加賀谷 希望, 土田 幸弘, 若狭 哲, 柳内 充, 共済医報, 68, Suppl., 111, 111, Oct. 2019
国家公務員共済組合連合会, Japanese

長期(3年以上)VAD治療の課題と対策 長期植込型補助人工心臓治療の現状、課題、そして対策　　　　　　　　　　　　　　　
大岡 智学, 加藤 伸康, 新宮 康栄, 若狭 哲, 加藤 裕貴, 松居 喜朗, 寒河江 磨, 矢萩 亮児, 櫛引 勝年, 加藤 美香, 人工臓器, 48, 2, S, 75, Oct. 2019
(一社)日本人工臓器学会, Japanese

重症心不全に対する左室介入手術の功罪
松居喜郎, 新宮康栄, 若狭哲, 久保田卓, 大岡智学, 加藤信康, 加藤裕貴, 日本心臓血管外科学会学術総会(Web), 49回, [Ex, 3], Feb. 2019
(NPO)日本心臓血管外科学会, Japanese

補助循環・外科療法 左室形成術・僧帽弁関連手術
松居喜郎, 新宮康栄, 若狭哲, 大岡智学, 久保田卓, 日本臨床, 77, 増刊1 心不全(中), 446, 451, Feb. 2019
(株)日本臨床社, Japanese

EVAR術後エンドリークに対するステントグラフト温存瘤縫縮術
佐藤公治, 須野賢一郎, 若狭哲, 日本血管外科学会雑誌(Web), 28, Supplement, 2019

慢性B型大動脈解離に対するTEVAR後遠隔期再介入の検討
佐藤公治, 若狭哲, 杉木宏司, 久保田卓, 上田秀樹, 日本胸部外科学会定期学術集会(Web), 72nd, 2019

EVAR後type II ELの治療戦略 EVAR術後エンドリークに対するステントグラフト温存瘤縫縮術　　　　　　　　　　　　　　　
佐藤 公治, 須野 賢一郎, 若狭 哲, 日本血管外科学会雑誌, 28, Suppl., PR6, 1, 2019
(NPO)日本血管外科学会, Japanese

急性及び慢性B型大動脈解離に対する胸部ステントグラフトが凝固線溶系に与える影響　　　　　　　　　　　　　　　
佐藤 公治, 久保田 卓, 上田 秀樹, 若狭 哲, 日本血管外科学会雑誌, 27, Suppl., O21, 2, Jun. 2018
(NPO)日本血管外科学会, Japanese

Mitochondrial Dysfunction in Epicardial Adipose Tissue is Associated with Coronary Artery Stenosis
NAKAJIMA Takayuki, YOKOTA Takashi, SHINGU Yasushige, YAMADA Akira, IBA Yutaka, UJIHIRA Kosuke, WAKASA Satoru, OOKA Tomonori, TAKADA Shingo, SHIRAKAWA Ryosuke, FURIHATA Takaaki, TSUDA Masaya, MATSUMOTO Junichi, KATAYAMA Takashi, FUKUSHIMA Arata, SAITO Akimichi, MATSUOKA Ryosuke, NISHIHARA Hiroshi, MATSUI Yoshiro, KINUGAWA Shintaro, 日本循環器学会学術集会(Web), 82nd, 2018

急性及び慢性B型大動脈解離に対する胸部ステントグラフトが凝固線溶系に与える影響
佐藤公治, 久保田卓, 上田秀樹, 若狭哲, 日本血管外科学会雑誌(Web), 27, Supplement, ROMBUNNO.O21‐2(J‐STAGE), 2018
Japanese

ハイブリッドオペ後2年の吻合部狭窄にてPROPATENを使用した一例の転帰
松井欣哉, 長谷川幸生, 川崎浩一, 齋藤克憲, 若狭哲, 日本血管外科学会雑誌(Web), 27, Supplement, ROMBUNNO.P32‐7(J‐STAGE), 2018
Japanese

Blow‐out型左室破裂の1救命例
須野賢一郎, 佐藤公治, 若狭哲, 日本循環器学会北海道地方会(Web), 119th, HOKKAIDO119,1 (WEB ONLY), 2018
Japanese

TypeIIIbエンドリークによる瘤拡大に対する胸部ステントグラフト温存直達手術の経験
佐藤公治, 若狭哲, 北海道外科雑誌, 62, 2, 189, 20 Dec. 2017
Japanese

高度粥状硬化病変を有する弓部大動脈瘤に対する胸部ステントグラフト内挿術時の脳梗塞予防の工夫
小倉直浩, 小倉直浩, 小倉直浩, 阿部文靖, 鍋島豊, 佐藤崇太, 棚田智之, 大宮裕樹, 山内孝, 若狭哲, 人工臓器(日本人工臓器学会), 46, 2, S.127, 31 Aug. 2017
Japanese

大血管転位症3型に対する当院の治療戦略 体肺動脈短絡術+短周径肺動脈絞扼術(BT-shunt with tight PAB)の有効性　　　　　　　　　　　　　　　
加藤 伸康, 橘 剛, 佐々木 理, 泉 岳, 山澤 弘州, 武田 充人, 新宮 康栄, 若狭 哲, 加藤 裕貴, 大岡 智学, 松居 喜郎, 日本小児循環器学会雑誌, 33, Suppl.1, s1, 224, Jul. 2017
(NPO)日本小児循環器学会, Japanese

人工血管を用いたバイパス術により軽快したabdominal anginaの1例
古川夕里香, 安東悟央, 村瀬亮太, 杉本聡, 佐藤公治, 加藤伸康, 新宮康栄, 加藤裕貴, 若狭哲, 大岡智学, 橘剛, 松居喜郎, 北海道外科雑誌, 62, 1, 80, 20 Jun. 2017
Japanese

TypeIIエンドリークに対するステントグラフト温存直達手術　　　　　　　　　　　　　　　
佐藤 公治, 新宮 康栄, 太安 孝允, 加藤 伸康, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本血管外科学会雑誌, 26, Suppl., V4, 10, Jun. 2017
(NPO)日本血管外科学会, Japanese

Frailtyからみた腹部大動脈瘤開腹手術の成績　　　　　　　　　　　　　　　
村瀬 亮太, 新宮 康栄, 大岡 智学, 若狭 哲, 橘 剛, 松居 喜郎, 日本血管外科学会雑誌, 26, Suppl., O18, 3, Jun. 2017
(NPO)日本血管外科学会, Japanese

胸腹部動脈瘤術後脊髄障害予防を目的とした分節動脈再建法の工夫 再建動脈開存性の意義　　　　　　　　　　　　　　　
若狭 哲, 佐藤 公治, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本血管外科学会雑誌, 26, Suppl., P19, 8, Jun. 2017
(NPO)日本血管外科学会, Japanese

右冠動脈肺動脈起始症に対しreimplantation法、肺動脈欠損壁自己心膜パッチ形成術を施行した1例　　　　　　　　　　　　　　　
安東 悟央, 大岡 智学, 古川 夕里香, 村瀬 亮太, 杉本 聡, 佐藤 公治, 加藤 伸康, 浅井 英嗣, 太安 孝允, 新宮 康栄, 若狭 哲, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本血管外科学会雑誌, 26, Suppl., P37, 8, Jun. 2017
(NPO)日本血管外科学会, Japanese

冠動脈肺動脈起始症(ACAPA)と冠動脈肺動脈瘻の治療経験
安東 悟央, 大岡 智学, 古川 夕里香, 有村 聡士, 村瀬 亮太, 杉本 聡, 佐藤 公治, 加藤 伸康, 新宮 康栄, 若狭 哲, 橘 剛, 松居 喜郎, 太安 孝允, 加藤 裕貴, 北海道外科雑誌, 62, 1, 80, 80, Jun. 2017
北海道外科学会, Japanese

急性期にタクロリムスが原因とされる横紋筋融解症・多臓器不全を呈した心移植の1例　　　　　　　　　　　　　　　
大岡 智学, 大安 孝允, 新宮 康栄, 若狭 哲, 加藤 裕貴, 橘 剛, 松居 喜郎, 小林 真梨子, 櫛引 勝年, 移植, 52, 1, 90, 91, Apr. 2017
(一社)日本移植学会, Japanese

我が国の人工心臓治療の現況と展望 Destination Therapy導入に向け、5年間の植込型補助人工心臓によるBridge to Transplantationから何を学んだか?　　　　　　　　　　　　　　　
大岡 智学, 佐藤 公治, 新宮 康栄, 加藤 裕貴, 若狭 哲, 橘 剛, 松居 喜郎, 日本外科学会定期学術集会抄録集, 117回, SY, 5, Apr. 2017
(一社)日本外科学会, English

Mitochondrial Dysfunction in Epicardial Adipose Tissue is Associated with Coronary Artery Stenosis(和訳中)
中島 孝之, 横田 卓, 新宮 康栄, 山田 陽, 伊庭 裕, 若狭 哲, 大岡 智学, 高田 真吾, 白川 亮介, 降旗 高明, 津田 正哉, 松本 純一, 片山 貴史, 福島 新, 松居 喜郎, 絹川 真太郎, 日本循環器学会学術集会抄録集, 81回, PJ, 075, Mar. 2017
(一社)日本循環器学会, English

3D analysis of regional ventricle wall motion using high resolution CT images
Kimura Satomi, Kanai Satoshi, Date Hiroaki, Matsui Yoshirou, Wakasa Satoru, Proceedings of JSPE Semestrial Meeting, 2017, 231, 232, 2017
現在，心機能の評価では，心臓全体の運動を指標化する方法が一般的である．しかし，心不全の場合心臓の壁運動は局所的に不均一となり，拡張収縮運動が正常に行われている領域とその運動が殆ど見られない領域に分かれる為，診断・治療ではそれらの局所的な違いを解析する事が重要となる．そこで本研究では，時系列CT画像より3次元心内膜メッシュモデルを作成し，これらを利用した3次元運動解析を行った為，報告を行う．, The Japan Society for Precision Engineering, Japanese

植込み型補助人工心臓装着患者の在宅管理 北海道大学病院における植込型補助人工心臓装着患者に対する在宅管理の現状と課題　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 櫛引 勝年, 加藤 美香, 鴇田 智久, 矢萩 亮児, 寒河江 磨, 松居 喜郎, 人工臓器, 45, 2, S, 57, Oct. 2016
(一社)日本人工臓器学会, Japanese

TEVAR後のtypeIIエンドリークによる瘤拡大に対して動脈瘤直接切開による肋間動脈結紮および瘤縫縮を施行した1例　　　　　　　　　　　　　　　
村瀬 亮太, 若狭 哲, 杉本 聡, 佐藤 公治, 浅井 英嗣, 太安 孝允, 小林 一哉, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本血管外科学会雑誌, 25, Suppl., 228, 228, Jun. 2016
(NPO)日本血管外科学会, Japanese

感染性大動脈瘤手術における遠隔期再感染予防　　　　　　　　　　　　　　　
飯島 誠, 若狭 哲, 新宮 康栄, 加藤 裕貴, 大岡 智学, 橘 剛, 松居 喜郎, 日本血管外科学会雑誌, 25, Suppl., 251, 251, Jun. 2016
(NPO)日本血管外科学会, Japanese

鼠径部の人工血管感染に対して閉鎖孔バイパス術を施行した3例の経験　　　　　　　　　　　　　　　
須野 賢一郎, 新宮 康栄, 杉本 聡, 村瀬 亮太, 浅井 英嗣, 大安 孝允, 佐藤 公治, 飯島 誠, 小林 一哉, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本血管外科学会雑誌, 25, Suppl., 362, 362, Jun. 2016
(NPO)日本血管外科学会, Japanese

Surgical Strategy for Ischemic Mitral Regurgitation Adopting Subvalvular and Ventricular Procedures (vol 21, pg 370, 2015)
Satoru Wakasa, Yasushige Shingu, Tomonori Ooka, Hiroki Katoh, Tsuyoshi Tachibana, Yoshiro Matsui, ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, 22, 2, 125, 125, 2016
English, Others

小児先天性心疾患術後管理におけるトルバプタンの使用経験　　　　　　　　　　　　　　　
太安 孝允, 浅井 英嗣, 佐藤 公治, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲, 橘 剛, 松居 喜郎, 丸藤 哲, 日本集中治療医学会雑誌, 23, Suppl., 514, 514, Jan. 2016
(一社)日本集中治療医学会, Japanese

一期的に腹部大動脈瘤手術と脳死膵腎同時移植を実施した1例
藤居勇貴, 腰塚靖之, 財津雅昭, 川村典生, 後藤了一, 山下健一郎, 杉谷篤, 若狭哲, 松居喜郎, 嶋村剛, 北海道外科雑誌, 60, 2, 214, 20 Dec. 2015
Japanese

上行大動脈弓部置換術後の大動脈食道瘻に対し、TEVAR内挿後、胸腔鏡下食道切除術を施行した一例　　　　　　　　　　　　　　　
上村 志臣, 七戸 俊明, 村上 壮一, 海老原 裕磨, 倉島 庸, 鯉沼 潤吉, 田中 公貴, サシーム・パウデル, 若狭 哲, 平野 聡, Japanese Journal of Acute Care Surgery, 5, 2, 211, 211, Oct. 2015
日本Acute Care Surgery学会, Japanese

Stoke Work Index Predicts Left Ventricular Reverse Remodeling
Yasushige Shingu, Satoru Wakasa, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui, JOURNAL OF CARDIAC FAILURE, 21, 10, S157, S157, Oct. 2015
English, Summary international conference

Bridge to recoverとなったHeartmate II装着例に対する治療経験　　　　　　　　　　　　　　　
大岡 智学, 浅井 英嗣, 佐藤 公治, 小林 一哉, 新宮 康栄, 加藤 裕貴, 若狭 哲, 橘 剛, 松居 喜郎, 人工臓器, 44, 2, S, 156, Oct. 2015
(一社)日本人工臓器学会, Japanese

心移植直後に発症した、タクロリムスによると思われる横紋筋融解を呈した1例　　　　　　　　　　　　　　　
大岡 智学, 大安 孝允, 佐藤 公治, 小林 一哉, 新宮 康栄, 加藤 裕貴, 若狭 哲, 櫛引 勝年, 小林 真梨子, 松居 喜郎, 移植, 50, 総会臨時, 383, 383, Sep. 2015
(一社)日本移植学会, Japanese

心臓血管 small volume centerにおける慢性血栓性肺高血圧症に対する肺動脈血栓内膜摘除の成績　　　　　　　　　　　　　　　
大岡 智学, 関 達也, 内藤 祐嗣, 新宮 康栄, 若狭 哲, 橘 剛, 松居 喜郎, 日本外科学会定期学術集会抄録集, 115回, OP, 184, Apr. 2015
(一社)日本外科学会, Japanese

MsEPの消失が超低体温循環停止時の脳血流低下よるものと推察された胸腹部大動脈瘤の一例
山本雅史, 村上望, 奥原浩之, 市川智大, 藤田和華子, 中根進児, 渋谷斉, 加畑馨, 若狭哲, 松居喜郎, 清水力, 臨床神経生理学, 43, 5, 2015

北大関連病院データベース(HOCARD)を用いた腹部大動脈瘤破裂の検討　　　　　　　　　　　　　　　
佐藤 公治, 若狭 哲, 浅井 英嗣, 太安 孝允, 関 達也, 内藤 祐嗣, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本心臓血管外科学会雑誌, 44, Suppl., 283, 283, Jan. 2015
(NPO)日本心臓血管外科学会, Japanese

左室形態からみた虚血性心筋症に対する左室形成と乳頭筋接合術の意義　　　　　　　　　　　　　　　
若狭 哲, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本心臓血管外科学会雑誌, 44, Suppl., 343, 343, Jan. 2015
(NPO)日本心臓血管外科学会, Japanese

心大血管再手術138例の検討　　　　　　　　　　　　　　　
内藤 祐嗣, 新宮 康栄, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本心臓血管外科学会雑誌, 44, Suppl., 376, 376, Jan. 2015
(NPO)日本心臓血管外科学会, Japanese

僧帽弁収縮期前方運動と左室流出路狭窄に対する心室中隔切除術の検討　　　　　　　　　　　　　　　
新宮 康栄, 若狭 哲, 大岡 智学, 橘 剛, 杉木 宏司, 松居 喜郎, 日本心臓血管外科学会雑誌, 44, Suppl., 392, 392, Jan. 2015
(NPO)日本心臓血管外科学会, Japanese

末梢吻合部位の深さからみた遠位弓部大動脈瘤に対するstaged repair選択基準の検討　　　　　　　　　　　　　　　
佐藤 公治, 若狭 哲, 浅井 英嗣, 太安 孝允, 関 達也, 内藤 祐嗣, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本心臓血管外科学会雑誌, 44, Suppl., 438, 438, Jan. 2015
(NPO)日本心臓血管外科学会, Japanese

遠隔成績を鑑みて、機能性三尖弁閉鎖不全に対する弁輪形成術単独は十分か?　　　　　　　　　　　　　　　
大岡 智学, 関 達也, 内藤 祐嗣, 新宮 康栄, 若狭 哲, 橘 剛, 松居 喜郎, 日本心臓血管外科学会雑誌, 44, Suppl., 236, 236, Jan. 2015
(NPO)日本心臓血管外科学会, Japanese

正中弓状靭帯症候群を合併した下膵十二指腸動脈瘤2例の治療経験
加藤拓也, 蒲池浩文, 敦賀陽介, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 神山俊哉, 若狭哲, 大岡智学, 阿保大介, 作原祐介, 松居喜郎, 武冨紹信, 日本外科学会定期学術集会(Web), 115th, RS-19-7 (WEB ONLY), 7, 2015
(一社)日本外科学会, Japanese

下膵十二指腸動脈瘤に正中弓状靭帯症候群を合併した2例の治療経験
加藤拓也, 蒲池浩文, 敦賀陽介, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 若狭哲, 大岡智学, 阿保大介, 作原祐介, 北海道外科雑誌, 59, 2, 190, 190, 20 Dec. 2014
北海道外科学会, Japanese

バイパス術後にIVRにて治療し得た未破裂膵十二指腸動脈瘤の1例
木井修平, 蒲池浩文, 敦賀陽介, 若山顕治, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 阿保大介, 若狭哲, IVR, 29, 4, 426, 426, 01 Dec. 2014
(一社)日本インターベンショナルラジオロジー学会, Japanese

EVAHEART装着後のMRSA縦隔炎及びポンプポケット感染例に対するJarvik2000換装(左開胸)の経験　　　　　　　　　　　　　　　
大岡 智学, 内藤 祐嗣, 新宮 康栄, 若狭 哲, 橘 剛, 松居 喜郎, 人工臓器, 43, 2, S, 149, Sep. 2014
(一社)日本人工臓器学会, Japanese

北海道における心臓移植報告　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 若狭 哲, 松居 喜郎, 榊原 守, 絹川 真太郎, 筒井 裕之, 小林 真梨子, 久保田 卓, 杉木 宏司, 日本移植学会総会プログラム抄録集, 50回, 431, 431, Aug. 2014
(一社)日本移植学会, Japanese

北海道大学における植込型補助人工心臓治療及び心臓移植実施体制の現状　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 絹川 真太郎, 榊原 守, 筒井 裕之, 小林 真梨子, 浅野 恵子, 寒河江 磨, 法邑 まなみ, 矢萩 亮児, 加藤 伸彦, 移植, 49, 1, 192, 193, May 2014
(一社)日本移植学会, Japanese

PD-2-4 心大血管再手術のPitfalls(PD-2 パネルディスカッション(2)心臓再手術のPitfalls,第114回日本外科学会定期学術集会)
松居 喜郎, 内藤 祐嗣, 新宮 康栄, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 久保田 卓, 日本外科学会雑誌, 115, 2, 171, 171, 05 Mar. 2014
一般社団法人日本外科学会, Japanese

VL-4 大動脈弁形成術を伴うRemodeling法による弁温存大動脈塞部再建術(VL-4 映像による私の手術手技(4),第114回日本外科学会定期学術集会)
松居 喜郎, 新宮 康栄, 若狭 哲, 大岡 智学, 加藤 裕貴, 裕貴 剛, 久保田 卓, 日本外科学会雑誌, 115, 2, 241, 241, 05 Mar. 2014
一般社団法人日本外科学会, Japanese

OP-098-6 大動脈瘤手術時の肋間動脈再建法の検討 : internal cuff reimplantation法の有用性(OP-098 大血管 胸部・その他,一般演題,第114回日本外科学会定期学術集会)
若狭 哲, 内藤 祐嗣, 久保田 卓, 関 達也, 小林 一哉, 新宮 康栄, 大岡 智学, 橘 剛, 松居 喜郎, 日本外科学会雑誌, 115, 2, 489, 489, 05 Mar. 2014
一般社団法人日本外科学会, Japanese

PS-019-1 拡張型心筋症術後のreverse remodelingと術前心仕事量拡張末期容積関係の勾配との関連(PS-019 心臓 虚血性疾患・移植・その他,ポスターセッション,第114回日本外科学会定期学術集会)
新宮 康栄, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 115, 2, 612, 612, 05 Mar. 2014
一般社団法人日本外科学会, Japanese

心臓再手術のPitfalls 心大血管再手術のPitfalls　　　　　　　　　　　　　　　
松居 喜郎, 内藤 祐嗣, 新宮 康栄, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 久保田 卓, 日本外科学会雑誌, 115, 臨増2, 171, 171, Mar. 2014
(一社)日本外科学会, Japanese

大動脈弁形成術を伴うRemodeling法による弁温存大動脈塞部再建術　　　　　　　　　　　　　　　
松居 喜郎, 新宮 康栄, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 久保田 卓, 日本外科学会雑誌, 115, 臨増2, 241, 241, Mar. 2014
(一社)日本外科学会, Japanese

当科におけるTOFの肺動脈二尖弁に対する自己弁温存の術式と変遷　　　　　　　　　　　　　　　
加藤 伸康, 橘 鹿, 浅井 英嗣, 安東 悟央, 関 達也, 小林 一哉, 内藤 裕嗣, 新宮 康栄, 若狭 哲, 加藤 裕貴, 大岡 智学, 久保田 卓, 武田 充人, 松居 喜郎, 日本心臓血管外科学会雑誌, 43, Suppl., 443, 443, Jan. 2014
(NPO)日本心臓血管外科学会, Japanese

Complete Papillary Muscle Approximation is Associated with High Durability of Mitral Valve Repair for Ischemic Mitral Regurgitation
Satoru Wakasa, Yasushige Shingu, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui, JOURNAL OF CARDIAC FAILURE, 19, 10, S114, S114, Oct. 2013
English, Summary international conference

植込型補助人工心臓装着後の課題　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 北海道外科雑誌, 58, 1, 70, 70, Jun. 2013
北海道外科学会, Japanese

VF-048-3 機能的僧帽弁閉鎖不全症に対するpapillary muscle approximation with anterior suspension(VF ビデオフォーラム,第113回日本外科学会定期学術集会)
若狭 哲, 新宮 康栄, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-031-1 TOFに対する肺動脈弁温存/弁輪の工夫(PS ポスターセッション,第113回日本外科学会定期学術集会)
加藤 伸康, 橘 剛, 浅井 英嗣, 関 達也, 南田 太朗, 飯島 誠, 内藤 祐嗣, 新宮 康栄, 若狭 哲, 大岡 智学, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-032-3 ブタ心大動脈基部を用いた大動脈弁逸脱症モデルの構築(PS ポスターセッション,第113回日本外科学会定期学術集会)
関 達也, 新宮 康栄, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-033-4 術後心房細動患者では術後心筋興奮-収縮連関時間が延長している(PS ポスターセッション,第113回日本外科学会定期学術集会)
新宮 康栄, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-034-1 機能性僧帽弁逆流への僧帽弁形成術後に発生する機能性僧帽弁狭窄の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)
南田 大朗, 若狭 哲, 加藤 伸康, 関 達也, 浅井 英嗣, 飯島 誠, 内藤 祐嗣, 新宮 康栄, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-282-3 Marfan症候群における大血管病変に対する治療戦略(PS ポスターセッション,第113回日本外科学会定期学術集会)
内藤 祐嗣, 新宮 康栄, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

VF-048-3 機能的僧帽弁閉鎖不全症に対するpapillary muscle approximation with anterior suspension(VF ビデオフォーラム,第113回日本外科学会定期学術集会)
若狭 哲, 新宮 康栄, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 465, 465, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-031-1 TOFに対する肺動脈弁温存/弁輪の工夫(PS ポスターセッション,第113回日本外科学会定期学術集会)
加藤 伸康, 橘 剛, 浅井 英嗣, 関 達也, 南田 太朗, 飯島 誠, 内藤 祐嗣, 新宮 康栄, 若狭 哲, 大岡 智学, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 560, 560, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-032-3 ブタ心大動脈基部を用いた大動脈弁逸脱症モデルの構築(PS ポスターセッション,第113回日本外科学会定期学術集会)
関 達也, 新宮 康栄, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 562, 562, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-033-4 術後心房細動患者では術後心筋興奮-収縮連関時間が延長している(PS ポスターセッション,第113回日本外科学会定期学術集会)
新宮 康栄, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 563, 563, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-034-1 機能性僧帽弁逆流への僧帽弁形成術後に発生する機能性僧帽弁狭窄の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)
南田 大朗, 若狭 哲, 加藤 伸康, 関 達也, 浅井 英嗣, 飯島 誠, 内藤 祐嗣, 新宮 康栄, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 564, 564, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-282-3 Marfan症候群における大血管病変に対する治療戦略(PS ポスターセッション,第113回日本外科学会定期学術集会)
内藤 祐嗣, 新宮 康栄, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 914, 914, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

心臓・大血管手術における止血法の工夫 TFF(TachoSil-Fibrin-Felt)StripとTF Sheet　　　　　　　　　　　　　　　
松居 喜郎, 若狭 哲, 新宮 康栄, 大岡 智学, 橘 剛, 久保田 卓, 日本心臓血管外科学会雑誌, 42, Suppl., 193, 193, Feb. 2013
(NPO)日本心臓血管外科学会, Japanese

機能性三尖弁閉鎖不全に対する弁輪形成術後中等度以上の遺残閉鎖不全は予測可能か?　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 日本心臓血管外科学会雑誌, 42, Suppl., 363, 363, Feb. 2013
(NPO)日本心臓血管外科学会, Japanese

当科で施行したTOF術後成人期(16歳以上)での再手術症例の検討
KATO NOBUYASU, ASAI HIDETSUGU, SEKI TATSUYA, MINAMIDA TARO, IIJIMA MAKOTO, NAITO YUJI, SHINGU YASUSHIGE, WAKASA SATORU, OOKA TOMONORI, TACHIBANA TSUYOSHI, KUBOTA SUGURU, MATSUI YOSHIRO, 日本成人先天性心疾患学会雑誌, 2, 1, 83, 83, Jan. 2013
日本成人先天性心疾患学会, Japanese

TCPC conversion時にextra cardiac routeにおける工夫と右室縫縮を施行した一例　　　　　　　　　　　　　　　
浅井 英嗣, 加藤 伸康, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 古川 卓朗, 武井 黄太, 山澤 弘州, 武田 充人, 上野 倫彦, 日本成人先天性心疾患学会雑誌, 2, 1, 109, 109, Jan. 2013
日本成人先天性心疾患学会, Japanese

植込型補助人工心臓承認によって重症心不全治療はどう変わったか? 重症心不全患者に対する左室形成術の成績から見た植込型補助人工心臓装着を含む外科的重症心不全治療戦略　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 人工臓器, 41, 2, S, 33, Nov. 2012
(一社)日本人工臓器学会, Japanese

Left-ventriclar electromechanical delay is prolonged in patients with postperative atrial fibrillation
新宮 康栄, 久保田 卓, 若狭 哲, 夷岡 徳彦, 森 大輔, 大岡 智学, 橘 剛, 松居 喜郎, 北海道醫學雜誌 = Acta medica Hokkaidonensia, 87, 6, 268, 268, 01 Nov. 2012
Japanese

Left Ventriculoplasty and Mitral Complex Reconstruction for Dilated Cardiomyopathy
Yoshiro Matsui, Yasushige Shingu, Satoru Wakasa, Tomonori Ooka, Tsuyoshi Tachibana, Suguru Kubota, JOURNAL OF CARDIAC FAILURE, 18, 10, S134, S134, Oct. 2012
English, Summary international conference

重症左心不全に対する左室形成術後に左室拡張能改善と心筋酸素代謝軽減を認める
千葉知, 納谷昌直, 吉永恵一郎, 岩野弘幸, 山田聡, 若狭哲, 新宮康栄, 久保田卓, 松居喜郎, 筒井裕之, 玉木長良, 核医学, 49, 3, 261, 31 Aug. 2012
Japanese

重症左心不全患者に対する修正左室形成術(オーバーラッピング法)前後の左室拡張能と心筋酸素代謝の検討
千葉知, 納谷昌直, 岩野弘幸, 吉永恵一郎, 山田聡, 若狭哲, 松居喜郎, 玉木長良, 筒井裕之, 日本心臓病学会誌, 7, Supplement 1, 339, 06 Aug. 2012
Japanese

左室形成術は局所的な左室壁基部の収縮機能を改善する : QGSの左室壁 thickening による検討
久保田 卓, 松井 欣哉, 若狭 哲, 須藤 行雄, 佐々木 重幸, 吉永 恵一郎, 松居 喜郎, 北海道醫學雜誌 = Acta medica Hokkaidonensia, 87, 4, 191, 191, 01 Aug. 2012
Japanese

VWS-1-4 僧帽弁複合体形成術 : 僧帽弁輪縫縮・乳頭筋接合・乳頭筋つり上げ(VWS-1 ビデオワークショップ(1)機能的僧帽弁逆流に対する術式の工夫,第112回日本外科学会定期学術集会)
松居 喜郎, 新宮 康栄, 内藤 祐嗣, 夷岡 徳彦, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 日本外科学会雑誌, 113, 2, 261, 261, 05 Mar. 2012
一般社団法人日本外科学会, Japanese

SF-080-2 傍腎動脈腹部大動脈瘤手術における常温腎動脈上遮断の安全性(SF-080 サージカルフォーラム(80)末梢血管 臨床,第112回日本外科学会定期学術集会)
内藤 祐嗣, 夷国 徳彦, 新宮 康栄, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 113, 2, 392, 392, 05 Mar. 2012
一般社団法人日本外科学会, Japanese

SF-105-4 大動脈弁置換術非適応患者の手術危険率予測スコア評価 : 北海道における実情調査アンケート結果(SF-105 サージカルフォーラム(105)心臓,第112回日本外科学会定期学術集会)
関 達也, 新宮 康栄, 榊原 守, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 筒井 裕之, 松居 喜郎, 日本外科学会雑誌, 113, 2, 428, 428, 05 Mar. 2012
一般社団法人日本外科学会, Japanese

PS-153-2 先天性心疾患に対する右室流出路形成術後の再右室流出路再建例の検討(心臓小児・弁膜症,ポスターセッション,第112回日本外科学会定期学術集会)
浅井 英嗣, 松居 喜朗, 久保田 卓, 橘 剛, 大岡 智学, 若狭 哲, 夷岡 徳彦, 内藤 裕嗣, 新宮 康栄, 南田 太朗, 関 達也, 日本外科学会雑誌, 113, 2, 797, 797, 05 Mar. 2012
一般社団法人日本外科学会, Japanese

PS-153-5 溶血性貧血を伴う人工弁paravalvular leakに対する再置換術の早期手術成績に与える術前因子の検討(心臓小児・弁膜症,ポスターセッション,第112回日本外科学会定期学術集会)
久保田 卓, 関 達也, 浅井 英嗣, 新宮 康栄, 内藤 祐嗣, 夷岡 徳彦, 若狭 哲, 大岡 智学, 橘 剛, 松居 喜郎, 日本外科学会雑誌, 113, 2, 798, 798, 05 Mar. 2012
一般社団法人日本外科学会, Japanese

PS-153-7 SJM Tailor Ringを用いた二次性三尖弁閉鎖不全に対する弁輪形成術 : MC^3 ringとの比較(心臓小児・弁膜症,ポスターセッション,第112回日本外科学会定期学術集会)
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 113, 2, 798, 798, 05 Mar. 2012
一般社団法人日本外科学会, Japanese

PS-154-4 高齢者の大動脈弁置換術の成績(心臓弁膜症,ポスターセッション,第112回日本外科学会定期学術集会)
新宮 康栄, 関 達也, 久保田 卓, 若狭 哲, 大岡 智学, 橘 剛, 松居 喜郎, 日本外科学会雑誌, 113, 2, 799, 799, 05 Mar. 2012
一般社団法人日本外科学会, Japanese

PS-107-8 高周波焼灼デバイスを用いたメイズ手術 : 焼灼回数と貫壁性の検討(PS-107 心臓 虚血性疾患,ポスターセッション,第112回日本外科学会定期学術集会)
若狭 哲, 久保田 卓, 新宮 康栄, 大岡 智学, 橘 剛, 松居 喜郎, 日本外科学会雑誌, 113, 2, 706, 706, 05 Mar. 2012
一般社団法人日本外科学会, Japanese

新しい僧帽弁形成術 Measured Tube Techniqueによる人工腱策再建　　　　　　　　　　　　　　　
松居 喜郎, 新宮 康栄, 夷岡 徳彦, 若狭 哲, 杉木 宏司, 大岡 智学, 橘 剛, 久保田 卓, 日本心臓血管外科学会雑誌, 41, Suppl., 345, 345, Mar. 2012
(NPO)日本心臓血管外科学会, Japanese

静脈血リザーバ併用PCPS閉鎖回路による心筋負荷補助効果の実験的検討
飯島誠, 関達也, 浅井英嗣, 加藤伸康, 南田大朗, 夷岡徳彦, 内藤祐嗣, 新宮康栄, 若狭哲, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 北海道外科雑誌, 56, 2, 160, 161, 20 Dec. 2011
Japanese

北海道初の植込型補助人工心臓を用いた重症心不全治療の経験 院内治療体制構築からHub-Satellite Hospital systemへ　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 北海道外科雑誌, 56, 2, 156, 156, Dec. 2011
北海道外科学会, Japanese

北海道初の植込型補助人工心臓を用いた重症心不全治療の経験 院内治療体制構築からHub-Satellite Hospital systemへ　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 人工臓器, 40, 2, S134, S134, Oct. 2011
(一社)日本人工臓器学会, Japanese

最新の弁膜症治療 外科治療からカテーテル治療まで 虚血性僧帽弁逆流の外科治療　　　　　　　　　　　　　　　
松居 喜郎, 久保田 卓, 橘 剛, 大岡 智学, 若狭 哲, 新宮 康栄, 日本心臓病学会誌, 6, Suppl.I, 160, 160, Aug. 2011
(一社)日本心臓病学会, Japanese

心不全に対する外科治療 左室形成術と心臓移植、植込型補助人工心臓はどのようにすみ分けるか?　　　　　　　　　　　　　　　
松居 喜郎, 久保田 卓, 橘 剛, 大岡 智学, 若狭 哲, 新宮 康栄, 日本心臓病学会誌, 6, Suppl.I, 172, 172, Aug. 2011
(一社)日本心臓病学会, Japanese

心不全治療の新展開―外科医との共働による新たな治療戦略《心不全に対する外科治療の新展開》左室形成術・僧帽弁手術
松居喜郎, 若狭哲, 新宮康栄, 杉木宏司, 大岡智学, 久保田卓, 内科, 108, 1, 81, 86, 01 Jul. 2011
Japanese

左室形成術・僧帽弁手術 (特集 心不全治療の新展開--外科医との共働による新たな治療戦略) -- (心不全に対する外科治療の新展開)
松居 喜郎, 若狭 哲, 新宮 康栄, 内科, 108, 1, 81, 86, Jul. 2011
南江堂, Japanese

感染性大動脈瘤の診断におけるFDG‐PETの有用性
飯島誠, 澁谷千英子, 南田大朗, 小林一哉, 松井欣哉, 杉木宏司, 橘剛, 松居喜郎, 浅井英嗣, 加藤伸康, 夷岡徳彦, 内藤祐嗣, 若狭哲, 大岡智学, 久保田卓, 北海道外科雑誌, 56, 1, 69, 70, 20 Jun. 2011
Japanese

SF-067-1 PETを用いた心筋酸素代謝評価による重症僧帽弁閉鎖不全症手術指摘時期の検討(SF-067 サージカルフォーラム(67)心臓:基礎,第111回日本外科学会定期学術集会)
若狭 哲, 久保田 卓, 杉木 宏司, 大岡 智学, 橘 剛, 千葉 知, 吉永 恵一郎, 筒井 裕之, 玉木 長良, 松居 喜郎, 日本外科学会雑誌, 112, 1, 418, 418, 25 May 2011
一般社団法人日本外科学会, Japanese

感染性大動脈瘤の診断におけるFDG-PETの有用性
飯島誠, 浅井英嗣, 澁谷千英子, 加藤伸康, 南田太朗, 小林一哉, 内藤祐嗣, 夷岡徳彦, 松井欣哉, 若狭哲, 杉木宏司, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 日本血管外科学会雑誌, 20, 2, 2011

心大血管再手術80例の検討
内藤祐嗣, 夷岡徳彦, 松井欣哉, 若狭哲, 杉木宏司, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 日本心臓血管外科学会雑誌, 40, Supplement, 2011

虚血性僧帽弁閉鎖不全症に対する乳頭筋接合術の成績
若狭哲, 杉木宏司, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 日本心臓血管外科学会雑誌, 40, Supplement, 2011

過去10年間の医原性大腿動脈損傷の治療経験
松井欣哉, 飯島誠, 小林一哉, 夷岡徳彦, 若狭哲, 杉木宏司, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 日本血管外科学会雑誌, 20, 2, 2011

大動脈弁置換時に機能的2度僧帽弁逆流は放置しても良い?-MAP群との遠隔成績比較から-
久保田卓, 澁谷千英子, 夷岡徳彦, 松井欣哉, 若狭哲, 杉木宏司, 大岡智学, 橘剛, 松居喜郎, 日本心臓血管外科学会雑誌, 40, Supplement, 2011

上行弓部大動脈人工血管置換術に伴う大伏在静脈を用いた冠動脈バイパス術の検討
若狭哲, 国原孝, 久保田卓, 杉木宏司, 大岡智学, 橘剛, 椎谷紀彦, 松居喜郎, 日本血管外科学会雑誌, 20, 2, 2011

僧帽弁手術で二次性三尖弁閉鎖不全(TR)をどう扱う?-遺残TRの予測因子の検討-
大岡智学, 松居喜郎, 松井欣哉, 杉木宏司, 若狭哲, 橘剛, 久保田卓, 日本心臓血管外科学会雑誌, 40, Supplement, 2011

弁周囲逆流に対する手術の検討
内藤祐嗣, 夷岡徳彦, 若狭哲, 杉木宏司, 大岡智学, 加藤裕貴, 橘剛, 久保田卓, 松居喜郎, 北海道外科雑誌, 56, 1, 2011

メインボディーによる両側腎動脈閉塞をきたしたがmainbody pull-down法で腎動脈rescueに成功した腹部大動脈ステントグラフトの一例
澁谷千英子, 久保田卓, 若狭哲, 杉木宏司, 大岡智学, 橘剛, 松居喜郎, 北海道外科雑誌, 56, 1, 2011

体外設置型補助人工心臓(VAD)ABIOMED社MJ010の使用経験
大岡智学, 若狭哲, 久保田卓, 杉木宏司, 橘剛, 松居喜郎, 北海道外科雑誌, 56, 1, 2011

Mitral Complex Reconstruction and Left Ventriculoplasty for Functional Mitral Regurgitation With Dilated Cardiomyopathy
Yoshiro Matsui, Satoru Wakasa, Yasushige Shingu, Tomonori Ooka, Tsuyoshi Tachibana, Suguru Kubota, JOURNAL OF CARDIAC FAILURE, 16, 9, S137, S137, Sep. 2010
English, Summary international conference

僧帽弁逆流の手術時期 虚血性・拡張型心筋症における僧帽弁逆流　　　　　　　　　　　　　　　
松居 喜郎, 若狭 哲, 杉木 宏司, 大岡 智学, 橘 剛, 久保田 卓, 日本心臓病学会誌, 5, Suppl.I, 171, 171, Aug. 2010
(一社)日本心臓病学会, Japanese

三尖弁閉鎖不全に対するSJMT Tailor Ringを用いた三尖弁形成術の術後早期成績の検討　　　　　　　　　　　　　　　
大岡 智学, 松居 喜郎, 久保田 卓, 橘 剛, 若狭 哲, 北海道外科雑誌, 55, 1, 76, 76, Jun. 2010
北海道外科学会, Japanese

SV-2-2-3 虚血性/非虚血性拡張型心筋症に対する左室形成術(心臓・血管-2,特別ビデオセッション2,第110回日本外科学会定期学術集会)
松居 喜郎, 松井 欣哉, 夷岡 徳彦, 加藤 裕貴, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 日本外科学会雑誌, 111, 2, 50, 50, 05 Mar. 2010
一般社団法人日本外科学会, Japanese

OP-175-1 非虚血性拡張型心筋症に対する左室形成術の中期成績(心臓-3,一般口演,第110回日本外科学会定期学術集会)
若狭 哲, 新宮 康栄, 松井 欣哉, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 111, 2, 557, 557, 05 Mar. 2010
一般社団法人日本外科学会, Japanese

虚血性拡張型心筋症に対する左室形成術の中期成績~広範akinesis症例における術後左室容量の影響
若狭哲, 杉木宏司, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 日本冠動脈外科学会学術大会講演抄録集, 15th, 2010

ウェーブレット解析による新しい二葉弁機能不全診断基準の検討
杉木宏司, 久保田卓, 大岡智学, 橘剛, 若狭哲, 夷岡徳彦, 松井欣哉, 杉木健司, 松居喜郎, 人工臓器(日本人工臓器学会), 39, 2, 2010

二葉機械弁音のウェーブレット解析による新たな弁機能不全診断の試み
杉木宏司, 久保田卓, 大岡智学, 橘剛, 若狭哲, 松井欣哉, 内藤祐嗣, 夷岡徳彦, 杉木健司, 松居喜郎, 日本循環器学会北海道地方会(Web), 104th, 2010

心大血管手術における再手術症例(再胸骨正中切開)の検討
内藤祐嗣, 南田大朗, 飯島誠, 夷岡徳彦, 松井欣哉, 若狭哲, 杉木宏司, 大岡智学, 加藤裕貴, 橘剛, 久保田卓, 松居喜郎, 日本循環器学会北海道地方会(Web), 103rd, 2010

当科における補助人工心臓装着症例の検討
大岡智学, 夷岡徳彦, 内藤祐嗣, 松井欣哉, 杉木宏司, 若狭哲, 橘剛, 久保田卓, 松居喜郎, 日本循環器学会北海道地方会(Web), 103rd, 2010

JACVSD risk解析モデルとEuroSCOREとの比較検討
南田大朗, 夷岡徳彦, 松井欣哉, 若狭哲, 杉木宏司, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 日本循環器学会北海道地方会(Web), 103rd, 2010

Wavelet解析による二葉機械弁機能不全の診断criteriaの再検討
杉木宏司, 久保田卓, 大岡智学, 若狭哲, 橘剛, 杉木健司, 松居喜郎, 日本循環器学会北海道地方会(Web), 103rd, 2010

冠動脈手術領域におけるJapan scoreでの予測危険率の検討
杉木宏司, 南田大朗, 大岡智学, 久保田卓, 若狭哲, 橘剛, 夷岡徳彦, 松居喜郎, 日本冠動脈外科学会学術大会講演抄録集, 15th, 2010

虚血性心筋症に対する左室形成術の成績
若狭哲, 久保田卓, 杉木宏司, 大岡智学, 橘剛, 松居喜郎, 日本冠疾患学会雑誌, 16, 4, 2010

SAPHO症候群に合併した繰り返す大動脈弁輪部膿瘍に対する大動脈基部再置換術
若狭哲, 松井欣哉, 杉木宏司, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 日本血管外科学会雑誌, 19, 2, 2010

結核性胸腹部大動脈瘤破裂緊急手術の2症例の検討
松井欣哉, 夷岡徳彦, 若狭哲, 杉木宏司, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 日本血管外科学会雑誌, 19, 2, 2010

TEVAR時代の弓部open surgeryの成績
若狭哲, 杉木宏司, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 日本循環器学会北海道地方会(Web), 103rd, 2010

鈍的外傷による大腿動静脈損傷に対し,緊急下肢血行再建を行った1症例
松井欣哉, 渋谷千鶴子, 夷岡徳彦, 若狭哲, 杉木宏司, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 日本循環器学会北海道地方会(Web), 103rd, 2010

胸部下行大動脈に対する自作ステントグラフト治療の遠隔期成績
飯島誠, 松居喜郎, 久保田卓, 橘剛, 大岡智学, 杉木宏司, 若狭哲, 松井欣哉, 夷岡徳彦, 内藤祐嗣, 河合昭浩, 澁谷千英子, 日本循環器学会北海道地方会(Web), 103rd, 2010

大動脈弁置換に併施した僧帽弁輪形成術の検討
久保田卓, 澁谷千英子, 内藤祐嗣, 夷岡徳彦, 松井欣哉, 杉木宏司, 若狭哲, 大岡智学, 橘剛, 松居喜郎, 日本循環器学会北海道地方会(Web), 103rd, 2010

収縮期前方運動を伴った閉塞性肥大型心筋症の対する僧帽弁形成術-sliding leaflet technique-
久保田卓, 河合昭浩, 内藤祐嗣, 夷岡徳彦, 松井欣哉, 杉木宏司, 若狭哲, 大岡智学, 橘剛, 松居喜郎, 日本循環器学会北海道地方会(Web), 104th, 2010

内科的コントロール中に大動脈基部拡大を来たし再手術を要した大動脈炎症候群の1例
澁谷千英子, 加藤伸康, 内藤祐司, 夷岡徳彦, 松井欣哉, 若狭哲, 杉木宏司, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 日本循環器学会北海道地方会(Web), 103rd, 2010

重症心不全に対する左室形成術~酢酸PETによる心筋酸素消費量評価に基づいたresponder判別の試み
若狭哲, 杉木宏司, 大岡智学, 橘剛, 久保田卓, 松居喜郎, General Thoracic and Cardiovascular Surgery, 58, Supplement, 2010

胸腹部大動脈瘤手術における脊髄モニターとしてのmotor evoked potential
若狭哲, 杉木宏司, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 北海道外科雑誌, 55, 1, 2010

FDG-PET-CTを用いた縦隔炎の診断
南田大朗, 杉木宏司, 内藤祐嗣, 夷岡徳彦, 松井欣哉, 若狭哲, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 北海道外科雑誌, 55, 2, 2010

当科における感染性胸腹部大動脈瘤の外科治療
飯島誠, 澁谷千英子, 河合昭浩, 加藤伸康, 南田大朗, 内藤祐嗣, 夷岡徳彦, 松井欣哉, 若狭哲, 杉木宏司, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 北海道外科雑誌, 55, 2, 2010

大腿深部動脈内膜摘除後11年経過し,大腿動脈瘤を生じた1例
松井欣哉, 内藤祐嗣, 夷岡徳彦, 若狭哲, 杉木宏司, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 北海道外科雑誌, 55, 2, 2010

三尖弁閉鎖不全に対する人工弁輪を用いた三尖弁形成術の術後早期成績の検討　　　　　　　　　　　　　　　
大岡 智学, 夷岡 徳彦, 松井 欣哉, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 日本心臓血管外科学会雑誌, 39, Suppl., 272, 272, Jan. 2010
(NPO)日本心臓血管外科学会, Japanese

TA(Ib)に対するAPC後Af,PATに対してEC conversion,right side MAZEを行った一例
TACHIBANA TSUYOSHI, ABE SHINJI, NAITO YUJI, EBUOKA NORIYOSHI, SHINGU YASUSHIGE, MATSUI KIN'YA, SUGIKI TAKASHI, WAKASA SATOSHI, OOKA TOMONORI, YAMAKAWA SATOSHI, KUBOTA SUGURU, SHIIYA NORIHIKO, MURASHITA TOSHIFUMI, MATSUI YOSHIRO, Gen Thorac Cardiovasc Surg, 57, 8, 7, 10 Aug. 2009
Japanese

拡張型心筋症と僧帽弁閉鎖不全症例における外科治療の心筋酸素代謝に対する効果
杉木孝司, 納谷昌直, 新宮康栄, 松井欣也, 若狭哲, 久保田卓, 椎谷紀彦, 筒井裕之, 玉木長良, 松居喜郎, Gen Thorac Cardiovasc Surg, 57, 8, 15, 10 Aug. 2009
Japanese

The development of surgical treatment for congenital heart disease
TACHIBANA TSUYOSHI, EBUOKA NORIYOSHI, MATSUI KIN'YA, WAKASA SATORU, OOKA TOMONORI, KUBOTA SUGURU, MATSUI YOSHIRO, 北海道外科雑誌, 54, 1, 2, 5, 20 Jun. 2009
Japanese

¹¹C‐酢酸PETを用いた心筋代謝効率の左室形成術による変化についての検討
杉木孝司, 納谷昌直, 新宮康栄, 松井欣也, 若狭哲, 大岡智学, 久保田卓, 椎谷紀彦, 玉木長良, 筒井裕之, 松居喜郎, 日本心臓血管外科学会雑誌, 38, Supplement, 351, 20 Mar. 2009
Japanese

当科における慢性血栓塞栓性肺高血圧症に対する肺動脈血栓内膜摘除症例の検討　　　　　　　　　　　　　　　
大岡 智学, 夷岡 徳彦, 新宮 康栄, 杉木 孝司, 松井 欣哉, 若狭 哲, 橘 剛, 久保田 卓, 山川 智士, 椎谷 紀彦, 松居 喜郎, 安藤 太三, 日本心臓血管外科学会雑誌, 38, Suppl., 324, 324, Mar. 2009
(NPO)日本心臓血管外科学会, Japanese

VS-008-4 二弁置換手術が必要な人工弁感染及び僧帽弁位人工弁周囲逆流症例におけるManouguian法の工夫 : double-layered patchによるintervalvular fibrous body reconstruction(心臓:後天性疾患,ビデオセッション,第109回日本外科学会定期学術集会)
大岡 智学, 夷岡 徳彦, 新宮 康栄, 杉木 孝司, 松井 欣哉, 若狭 哲, 橘 剛, 久保田 卓, 椎谷 紀彦, 松居 喜郎, 日本外科学会雑誌, 110, 2, 378, 378, 25 Feb. 2009
一般社団法人日本外科学会, Japanese

21) CTによる大動脈弁,僧帽弁石灰化の定量的評価(第99回日本循環器学会北海道地方会)
新宮 康栄, 大山 徳子, 加藤 伸康, 夷岡 徳彦, 杉木 孝司, 若狭 哲, 大岡 智学, 橘 剛, 山川 智士, 久保田 卓, 椎谷 紀彦, 村下 十志文, 松居 喜郎, Circulation journal : official journal of the Japanese Circulation Society, 72, 0, 1073, 1073, 20 Oct. 2008
社団法人日本循環器学会, Japanese

23) 高度左室拡大及び低左心機能を伴った重症大動脈弁狭窄症に対する手術経験(第99回日本循環器学会北海道地方会)
久保田 卓, 夷岡 徳彦, 新宮 康栄, 松井 欣哉, 杉木 孝司, 若狭 哲, 大岡 智学, 橘 剛, 山川 智士, 椎谷 紀彦, 村下 十志文, 松居 喜郎, Circulation journal : official journal of the Japanese Circulation Society, 72, 0, 1073, 1073, 20 Oct. 2008
社団法人日本循環器学会, Japanese

片側肺血管床の発育不良、側副血行路の発達を認め、intrapulmonary septation(IPS)を施行した1例　　　　　　　　　　　　　　　
武井 黄太, 八鍬 聡, 武田 充人, 上野 倫彦, 村上 智明, 村下 十志文, 若狭 哲, 杉木 宏司, 日本小児循環器学会雑誌, 24, 4, 563, 563, Jul. 2008
(NPO)日本小児循環器学会, Japanese

PD-2-5 虚血性心筋症の外科治療戦略 : Overlapping法と僧帽弁複合体形成術(第108回日本外科学会定期学術集会)
新宮 康栄, 夷岡 徳彦, 松井 欣哉, 杉木 孝司, 若狭 哲, 橘 剛, 山川 智士, 久保田 卓, 椎谷 紀彦, 村下 十志文, 松居 喜郎, 日本外科学会雑誌, 109, 2, 123, 123, 25 Apr. 2008
一般社団法人日本外科学会, Japanese

SF-018-1 ウサギ脊髄虚血再灌流モデルにおけるastrocyte活性化と遅発性運動神経細胞死に関する検討(第108回日本外科学会定期学術集会)
若狭 哲, 椎谷 紀彦, 橘 剛, 久保田 卓, 村下 十志文, 松居 喜郎, 日本外科学会雑誌, 109, 2, 208, 208, 25 Apr. 2008
一般社団法人日本外科学会, Japanese

肺動脈絞扼術後のccTGA(SLL),VSD,dextracardiaに対して経左房でconventional repair,TVPを行った1例
TACHIBANA TAKESHI, ABE SHINJI, NAITO HIROSHI, EBISUOKA NORIHIKO, SHINGU YASUEI, MATSUI KIN'YA, SUGIKI KOJI, WAKASA SATOSHI, SUGIKI KOJI, YAMAKAWA SATOSHI, KUBOTA TAKASHI, SHIIYA NORIHIKO, MURASHITA TOSHIFUMI, MATSUI YOSHIRO, Gen Thorac Cardiovasc Surg, 56, 4, 16, 10 Apr. 2008
Japanese

Bulging sinusおよびePTFE弁付き導管を用いたRoss手術の治療経験
杉木孝司, 村下十志文, 若狭哲, 杉木宏司, 松居喜郎, 日本小児循環器学会雑誌, 24, 4, 2008

胸部下行領域におけるstent graftとopen surgeryの棲み分けと成績の現状
杉木孝司, 椎谷紀彦, 若狭哲, 杉木宏司, 久保田卓, 松居喜郎, General Thoracic and Cardiovascular Surgery, 56, 4, 2008

左冠動脈肺動脈起始症(ALCAPA)に対する左冠動脈主幹部形成による再建術
若狭哲, 村下十志文, 杉木孝司, 杉木宏司, 國原孝, 椎谷紀彦, 松居喜郎, General Thoracic and Cardiovascular Surgery, 56, 4, 2008

大動脈弁上狭窄に対する大動脈形成術(Myer法)の経験
杉木孝司, 村下十志文, 若狭哲, 杉木宏司, 國原孝, 椎谷紀彦, 松居喜郎, General Thoracic and Cardiovascular Surgery, 56, 4, 2008

大動脈解離に対するETの長期予後
新宮康栄, 阿部慎司, 内藤祐嗣, 松井欣哉, 若狭哲, 杉木宏司, 橘剛, 山川智士, 久保田卓, 椎谷紀彦, 村下十志文, 松居喜郎, General Thoracic and Cardiovascular Surgery, 56, 4, 2008

左室流出路狭窄を伴う大動脈弁狭窄症に対し弁置換術と心室中隔筋切除を同時施行した2例
阿部慎司, 内藤祐嗣, 新宮康栄, 松井欣哉, 若狭哲, 杉木宏司, 橘剛, 久保田卓, 山川智士, 椎谷紀彦, 村下十志文, 松居喜郎, General Thoracic and Cardiovascular Surgery, 56, 4, 2008

QGSを用いた左室形成術前後壁運動解析
松井欣哉, 阿部慎司, 夷岡徳彦, 内藤祐嗣, 新宮康栄, 杉木孝司, 若狭哲, 杉木宏司, 橘剛, 久保田卓, 山川智士, 椎谷紀彦, 村下十志文, 松居喜郎, General Thoracic and Cardiovascular Surgery, 56, 4, 2008

重症心不全に対する左室形成術による外科治療　　　　　　　　　　　　　　　
松居 喜郎, 新宮 康栄, 若狭 哲, 杉木 孝司, 松井 欣哉, 久保田 卓, 椎谷 紀彦, 村下 十志文, 志村 信一郎, 須藤 幸雄, 適応医学, 11, 2, 50, 56, Jan. 2008
拡張心に伴う重症心不全に対して、症例に応じOverlapping法あるいは乳頭筋接合術を加えた変法、さらに乳頭筋接合術単独施行を行った。今回これらの術式による中期遠隔成績を報告した。非虚血性拡張型心筋症(DCM)36例、虚血性拡張型心筋症(ICM)34例を対象とした。周術期は心臓関連死亡はなく、緊急手術の1例が脳障害、2例が肺炎で死亡した。中期成績では4例が心不全、1例が不整脈、5例が感染、2例が脳梗塞、1例が腎不全で死亡した。1年、3年生存率は順にDCM 59±5、59±5%、ICM 92±6、87±6%、total 75±6、72±6%であった。Overlapping法、乳頭筋接合術を組み合わせた左室形成術は短期的には比較的安全で、特に虚血性心筋症に対し心機能改善の意味で有効な術式であるが、中期成績では非心臓死が多く、術前状態の悪化する前の手術が重要であることが示唆された。, 日本適応医学会, Japanese

Juxtarenal AAA手術症例の検討
内藤 祐嗣, 阿部 慎司, 夷岡 徳彦, 新宮 康栄, 杉木 孝司, 松井 欣哉, 若狭 哲, 杉木 宏司, 橘 剛, 山川 智士, 久保田 卓, 椎谷 紀彦, 村下 十志文, 松居 喜郎, 北海道外科雑誌, 52, 2, 212, 212, Dec. 2007
北海道外科学会, Japanese

虚血性MRの病態と治療戦略 拡大心によるfunctional MRに対して僧帽弁輪形成にPapillary muscle approximationを加えた治療戦略　　　　　　　　　　　　　　　
久保田 卓, 松居 喜郎, 阿部 慎司, 夷岡 徳彦, 新宮 康栄, 杉木 孝司, 若狭 哲, 橘 剛, 山川 智士, 椎谷 紀彦, 村下 十志文, 日本冠疾患学会雑誌, 13, 4, 296, 296, Nov. 2007
(NPO)日本冠疾患学会, Japanese

41)左室縮小率からみたオーバーラッピング型左室形成術後の心機能(第97回日本循環器学会北海道地方会)
新宮 康栄, 松居 喜郎, 内藤 祐嗣, 松井 欣哉, 若狭 哲, 杉木 宏司, 橘 剛, 山川 智士, 久保田 卓, 椎谷 紀彦, 村下 十志文, Circulation journal : official journal of the Japanese Circulation Society, 71, 0, 1010, 1010, 20 Oct. 2007
社団法人日本循環器学会, Japanese

10)Freestyle生体弁を使用してfull root replacementを施行した症例の検討(第96回日本循環器学会北海道地方会)
杉木 孝司, 国原 孝, 若狭 哲, 杉木 宏司, 椎谷 紀彦, 村下 十志文, 松屑 喜郎, Circulation journal : official journal of the Japanese Circulation Society, 71, 0, 824, 824, 20 Apr. 2007
社団法人日本循環器学会, Japanese

特発性/虚血性拡張型心筋症に伴う tethering による僧帽弁閉鎖不全症に対する乳頭筋接合術を中心とする僧帽弁複合体再建術
松居 喜郎, 須藤 幸雄, 志村 信一郎, 若狭 哲, 杉木 宏司, 国原 孝, 椎谷 紀彦, 村下 十志文, 日本外科学会雑誌, 108, 2, 322, 322, 10 Mar. 2007
一般社団法人日本外科学会, Japanese

シャント閉鎖術後,自家静脈再建術後,再々発上腕動脈瘤の一例
松井欣哉, 椎谷紀彦, 新宮康栄, 杉木孝, 若狭哲, 杉木宏司, 橘剛, 山川智士, 久保田卓, 村下十志文, 松居喜郎, 日本臨床外科学会雑誌, 68, 9, 2007

開心術後のCEDV/RVEFモニタリングによる右室容量と中心静脈圧の変化
新宮康栄, 松井欣哉, 杉木孝司, 若狭哲, 杉木宏司, 橘剛, 山川智士, 久保田卓, 椎谷紀彦, 村下十志文, 松居喜郎, 日本臨床外科学会雑誌, 68, 9, 2007

先天性僧帽弁閉鎖不全に対する弁形成手技とその成績
村下十志文, 杉木宏司, 若狭哲, 松井欣哉, 杉木孝司, 椎谷紀彦, 松居喜郎, 日本小児循環器学会雑誌, 23, 3, 2007

重症心不全に対する左室形成術のpitfalls
松居喜郎, 杉木宏司, 若狭哲, 新宮康栄, 久保田卓, 椎谷紀彦, 村下十志文, 日本外科系連合学会誌, 32, 3, 2007

上行弓部大動脈置換術後における急性期心機能と脳性ナトリウム利尿ペプチド(BNP)
新宮康栄, 椎谷紀彦, 阿部慎司, 内藤祐嗣, 松井欣哉, 若狭哲, 杉木宏司, 橘剛, 山川智士, 久保田卓, 村下十志文, 松居喜郎, 脈管学, 47, Supplement, 2007

特発性拡張型心筋症に対する左室形成術(オーバーラッピング,乳頭筋接合)施行症例のQGS(quantitative gated SPECT)による局所壁運動・血流量評価
松井欣哉, 新宮康栄, 杉木孝司, 若狭哲, 杉木宏司, 橘剛, 久保田卓, 山川智士, 椎谷紀彦, 村下十志文, 松居喜郎, 吉永恵一郎, 玉木長良, 志村信一郎, 須藤幸雄, General Thoracic and Cardiovascular Surgery, 55, Supplement, 2007

左室縮小率からみたオーバーラッピング型左室形成術後の心機能
新宮康栄, 内藤祐嗣, 松井欣哉, 若狭哲, 杉木宏司, 橘剛, 山川智士, 久保田卓, 椎谷紀彦, 村下十志文, 松居喜郎, General Thoracic and Cardiovascular Surgery, 55, Supplement, 2007

遠位弓部hybrid治療後のステントmigrationの1例
松井欣哉, 椎谷紀彦, 内藤祐嗣, 新宮康栄, 杉木孝司, 若狭哲, 杉木宏司, 橘剛, 松崎賢司, 山川智, 久保田卓, 村下十志文, 松居喜郎, 北海道外科雑誌, 52, 2, 2007

新生児期より心室中隔欠損孔の狭小化を来したファロー四徴症の1例　　　　　　　　　　　　　　　
上野 倫彦, 武井 黄太, 八鍬 聡, 武田 充人, 村上 智明, 若狭 哲, 杉木 宏司, 村下 十志文, 日本小児科学会雑誌, 111, 1, 76, 77, Jan. 2007
(公社)日本小児科学会, Japanese

両方向性グレン術後にTCPC非適応となった症例の検討
若狭哲, 杉木宏司, 橘剛, 八田英一郎, 窪田武浩, 村下十志文, 安田慶秀, Japanese Journal of Thoracic and Cardiovascular Surgery, 54, 5, 2006

Bilateral superior vena cavaはstaged Fontan手術のリスクとなるか
若狭哲, 杉木宏司, 窪田武浩, 椎谷紀彦, 村下十志文, 松居喜郎, Japanese Journal of Thoracic and Cardiovascular Surgery, 54, 2006

乳児期に外科治療を要したASD+PH症例の検討
杉木宏司, 窪田武浩, 八田英一郎, 橘剛, 若狭哲, 村下十志文, 安田慶秀, Japanese Journal of Thoracic and Cardiovascular Surgery, 54, 5, 2006

Shaher 5A(intramural LCA)coronary patternのTGA(II)症例の治療経験
橘剛, 杉木孝司, 若狭哲, 杉木宏司, 山下知剛, 加藤裕貴, 松崎賢司, 八田英一郎, 国原孝, 窪田武浩, 椎谷紀彦, 村下十志文, 安田慶秀, Japanese Journal of Thoracic and Cardiovascular Surgery, 54, 5, 2006

機能的単心室を伴うB型大動脈弓離断症に対する胸骨正中切開アプローチ人工心肺非使用下弓部再建術
若狭哲, 村下十志文, 窪田武浩, 杉木宏司, 日本小児循環器学会雑誌, 22, 3, 2006

純型肺動脈閉鎖症に対する手術-右室冠動脈瘻および小さい右室が与える影響-
若狭哲, 村下十志文, 窪田武浩, 杉木宏司, 日本小児循環器学会雑誌, 22, 3, 2006

小児期僧帽弁形成術の遠隔成績-使用リングと成績の検討-
杉木宏司, 村下十志文, 若狭哲, 杉木孝司, 窪田武浩, 村上智明, 日本小児循環器学会雑誌, 22, 3, 2006

先天性僧帽弁閉鎖不全症に対する弁形成術の1例
若狭哲, 杉木孝司, 杉木宏司, 橘剛, 窪田武浩, 村下十志文, Japanese Journal of Thoracic and Cardiovascular Surgery, 54, 5, 2006

肺血流量を増加させないように管理しFontan循環に到達した心房錯位症候群の2例　　　　　　　　　　　　　　　
八鍬 聡, 村上 智明, 盛一 享徳, 武田 充人, 上野 倫彦, 若狭 哲, 杉木 宏司, 八田 英一郎, 窪田 武浩, 村下 十志文, 佐川 浩一, 石川 司郎, 角 秀秋, 日本小児循環器学会雑誌, 21, 4, 508, 508, Jul. 2005
(NPO)日本小児循環器学会, Japanese

新生児・乳児期混合型総肺静脈還流異常症(TAPVC)の治療方針とその妥当性　　　　　　　　　　　　　　　
窪田 武浩, 若狭 哲, 杉木 宏司, 橘 剛, 今村 道明, 村下 十志文, 安田 慶秀, 村上 智明, 上野 倫彦, 武田 充人, 日本小児循環器学会雑誌, 21, 3, 345, 345, May 2005
(NPO)日本小児循環器学会, Japanese

心嚢カテーテル留置によるlate tamponadeの予防効果について　　　　　　　　　　　　　　　
橘 剛, 若狭 哲, 杉木 宏司, 窪田 武浩, 村下 十志文, 安田 慶秀, 武田 充人, 上野 倫彦, 村上 智明, 日本小児循環器学会雑誌, 21, 3, 427, 427, May 2005
(NPO)日本小児循環器学会, Japanese

ファロー四徴症,両大血管右室起始症に対する根治術後に発生した肺動脈再狭窄の検討
八田英一郎, 若狭哲, 杉木宏司, 橘剛, 窪田武浩, 椎谷紀彦, 村下十志文, 安田慶秀, 日本心臓血管外科学会雑誌, 34, Supplement, 2005

ファロー型(TOFおよびDORV)根治手術における肺動脈弁輪温存症例の検討
杉木宏司, 窪田武浩, 八田英一郎, 橘剛, 若狭哲, 村下十志文, 今村道明, 村上智明, 上野倫彦, 日本小児循環器学会雑誌, 21, 3, 2005

Fontan型手術非到達例の検討
若狭哲, 杉木宏司, 橘剛, 今村道明, 窪田武浩, 村下十志文, 安田慶秀, 村上智明, 日本小児循環器学会雑誌, 21, 3, 2005

ファロー四徴症およびDORV根治手術における肺動脈弁輪温存症例の検討
杉木宏司, 窪田武浩, 八田英一郎, 橘剛, 若狭哲, 村下十志文, 椎谷紀彦, 安田慶秀, 日本小児循環器学会雑誌, 21, 4, 2005

Total Cavopulmonary connectionの術後に関わる因子は何か,自験例22例の検討
窪田武浩, 村下十志文, 今村道明, 八田英一郎, 橘剛, 若狭哲, 杉木宏司, 安田慶秀, 日本心臓血管外科学会雑誌, 34, Supplement, 2005

Cantrell症候群に合併したDORV,subaortic VSDの1例　　　　　　　　　　　　　　　
橘 剛, 若狭 哲, 八田 英一郎, 窪田 武浩, 村下 十志文, 安田 慶秀, 石川 友一, 武田 充人, 斎田 吉伯, 上野 倫彦, 村上 智明, 日本小児循環器学会雑誌, 20, 5, 560, 560, Sep. 2004
(NPO)日本小児循環器学会, Japanese

先天性心疾患開心術に対するminimal accessは患者に美容上の恩恵をもたらしたのか? 術後遠隔期での検証　　　　　　　　　　　　　　　
八田 英一郎, 窪田 武浩, 若狭 哲, 橘 剛, 村下 十志文, 安田 慶秀, 齋田 吉伯, 武田 充人, 上野 倫彦, 村上 智明, 日本小児循環器学会雑誌, 20, 3, 307, 307, May 2004
(NPO)日本小児循環器学会, Japanese

新生児大動脈縮窄症及び大動脈弓離断症に対する治療の検討　　　　　　　　　　　　　　　
八田 英一郎, 窪田 武浩, 若狭 哲, 橘 剛, 村下 十志文, 安田 慶秀, 齋田 吉伯, 武田 充人, 上野 倫彦, 村上 智明, 日本小児循環器学会雑誌, 20, 3, 354, 354, May 2004
(NPO)日本小児循環器学会, Japanese

心内膜床欠損症に対するmodified one patch法を行った3症例　　　　　　　　　　　　　　　
窪田 武浩, 若狭 哲, 橘 剛, 八田 英一郎, 村下 十志文, 安田 慶秀, 村上 智明, 上野 倫彦, 武田 充人, 齋田 吉伯, 日本小児循環器学会雑誌, 20, 3, 354, 354, May 2004
(NPO)日本小児循環器学会, Japanese

2. VSD根治術後に発症したfentanyl-induced muscle rigidityの1例(第69回日本小児外科学会北海道地方会)
若狭 哲, 加藤 裕貴, 橘 剛, 八田 英一郎, 窪田 武浩, 村下 十志文, 安田 慶秀, 日本小児外科学会雑誌, 40, 1, 101, 101, 2004
特定非営利活動法人 日本小児外科学会, Japanese

13) 大動脈解離におけるULP症例の外科的処置の検討
加藤 裕貴, 明神 一宏, 石橋 義光, 石井 浩二, 宮嵜 直樹, 若狭 哲, Japanese circulation journal, 64, 0, 734, 734, 20 Apr. 2000
社団法人日本循環器学会, Japanese

EBM循環器疾患の治療
三田村, 秀雄, 小室, 一成, 横井, 宏佳, 山下, 武志, 楽木, 宏実
中外医学社, Oct. 2001, 4498034708, 冊, Japanese, [Contributor]

重症心不全に対する自己心温存外科治療戦略　　　　　　　　　　　　　　　
若狭哲
重症心不全に対する非薬物治療を考える/アボットメディカル Web講演会, 01 Dec. 2021, Others
[Invited]

僧帽弁形成術/後尖逸脱症例　　　　　　　　　　　　　　　
若狭哲
僧帽弁形成術におけるマイテクニック/エドワーズ・オンライン座談会, 25 Nov. 2021, Others
[Invited]

心臓血管外科手術における止血の工夫　　　　　　　　　　　　　　　
若狭哲
第41回日本臨床麻酔学会学術集会 シンポジウム１「心臓手術の凝固管理」, 05 Nov. 2021, Nominated symposium
[Invited]

虚血性僧帽弁閉鎖不全症に対する外科治療戦略　　　　　　　　　　　　　　　
若狭哲
第74回日本胸部外科学会定期学術集会 ワークショップ 低左心機能を伴う虚血性閉鎖不全症 ～外科手術 vs Mitraclip～, 03 Nov. 2021, Nominated symposium
[Invited]

Subvalvular surgical procedure for functional mitral regurgitation　　　　　　　　　　　　　　　
Satoru Wakasa
MITRAPLUS kick-off meeting, 23 Oct. 2021, Public discourse
[Invited]

重症心不全外科治療とＮＯ吸入療法　　　　　　　　　　　　　　　
若狭哲
熊本県 iNO WEBフォーラム, 08 Oct. 2021, Public discourse
[Invited]

重症心不全外科治療とＮＯ吸入療法　　　　　　　　　　　　　　　
若狭哲
神奈川県心臓周術期 iNO WEBセミナー, 03 Sep. 2021, Public discourse
[Invited]

虚血性僧帽弁閉鎖不全症　　　　　　　　　　　　　　　
若狭哲
日本心臓血管外科学会U-40 online BLC, 17 Jul. 2021, Public discourse
[Invited]

Small Aortic Root, session 3　　　　　　　　　　　　　　　
Satoru Wakasa
Abbott Japan/China Mentorship Program, 24 Jun. 2021, Public discourse
[Invited]

Small Aortic Root, session 2　　　　　　　　　　　　　　　
Satoru Wakasa
Abbott Japan/China Mentorship Program, 17 Jun. 2021, Public discourse
[Invited]

Small Aortic Root, session 1　　　　　　　　　　　　　　　
Satoru Wakasa
Abbott Japan/China Mentorship Program, 03 Jun. 2021, Public discourse
[Invited]

Ischemic MR：touch or no touch？　　　　　　　　　　　　　　　
若狭哲
第51回日本心臓血管外科学会学術総会 卒後教育セミナー＜冠動脈＞, 19 Feb. 2021, Public discourse
[Invited]

心臓血管外科手術時の止血の工夫　　　　　　　　　　　　　　　
若狭哲
第51回日本心臓血管外科学会学術総会 ランチョンセミナー, 19 Feb. 2021, Oral presentation
[Invited]

左室リモデリングを中心に考える機能性僧帽弁閉鎖不全症に対する外科治療　　　　　　　　　　　　　　　
若狭哲
第51回日本心臓血管外科学会学術総会 シンポジウム2「心室拡大による機能性僧帽弁閉鎖不全症の外科治療」, 19 Feb. 2021, Nominated symposium
[Invited]

オープンステントグラフトを用いた胸部大動脈手術　　　　　　　　　　　　　　　
若狭哲
第24回九州心臓血管外科セミナー, 09 Jan. 2021
[Invited]

Mitral valve replacement for FMR　　　　　　　　　　　　　　　
Satoru Wakasa
Think Mitral – EACTS Live Webinar -, 10 Oct. 2020, English, Oral presentation
[Invited]

Functional mitral valve disease - Beyond annuloplasty: targeting the left ventricle　　　　　　　　　　　　　　　
Satoru Wakasa
32nd Annual Meeting of the European Association for Cardio-Thoracic Surgery, Milan, 18 Oct. 2018, English, Invited oral presentation
18 Oct. 2018 - 20 Oct. 2018, [Invited]

Who benefits from surgical ventricular restoration: consideration according to INTERMACS profiles　　　　　　　　　　　　　　　
Satoru Wakasa
21st Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery, Kobe, 07 Apr. 2013, English
04 Apr. 2013 - 07 Apr. 2013

Left ventriculoplasty for progressively deteriorated left ventricle with global akinesis due to ischaemic cardiomyopathy: Japanese surgical ventricular reconstruction group experience　　　　　　　　　　　　　　　
Satoru Wakasa
26th Annual Meeting of the European Association for Cardio-Thoracic Surgery, Barcelona, 29 Oct. 2012, English, Oral presentation
27 Oct. 2012 - 31 Oct. 2012

Complete papillary muscle approximation could prevent the recurrence of functional mitral regurgitaion effectively in patients with severe heart failure　　　　　　　　　　　　　　　
若狭 哲
24th Annual Meeting of the European Association for Cardio-Thoracic Surgery, Geneva, 13 Sep. 2010
11 Sep. 2010 - 15 Sep. 2010

Integrated surgical approach with overlapping left ventriculoplasty and papillary muscle approximation for patients with severe heart failure due to ischemic dilated cardiomyopathy　　　　　　　　　　　　　　　
Satoru Wakasa
Masters in Repair of Structural Heart Disease, Miami, 2010

Influence of right ventricular-coronary artery fistula and right ventricular morphology on surgery of pulmonary atresia and intact ventricular septum　　　　　　　　　　　　　　　
若狭 哲
14th Annual Meeting of the Asian Society for Cardiovascular Surgery, Osaka, 2006

胸部大血管手術～私の工夫　　　　　　　　　　　　　　　
若狭哲
第11回浜松心臓血管外科研究会, Invited oral presentation
[Invited]

重症虚血性僧帽弁閉鎖不全症に対する弁下組織介入形成術のNCD利用多施設共同研究
科学研究費助成事業 基盤研究(C)
01 Apr. 2022 - 31 Mar. 2025
中村 賢, 國原 孝, 尾辻 豊, 上嶋 徳久, 荒井 裕国, 松宮 護郎, 高梨 秀一郎, 夜久 均, 松居 喜郎, 若狭 哲, 小宮 達彦, 本村 昇
日本学術振興会, 基盤研究(C), 東京慈恵会医科大学, 22K08964

A new thermally deformable mitral valve annuloplasty ring
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
01 Apr. 2017 - 31 Mar. 2020
Matsui Yoshiro
We developed a novel thermally deformable mitral annuloplasty ring to address the problems in mitral valve surgery. We assessed the ring's mechanical properties and its effect on the mitral valve anatomy. This ring was made of polycaprolactone. In the mechanical tests, the ring's yield point was greater than the deformation force of the annulus in humans. In pigs with deformation from "4:3" to "4:2", the coaptation length was significantly increased in each mitral valve part. Asymmetrical ring deformation increased the coaptation length only at the deformed area. In conclusion, this new thermally deformable mitral annuloplasty ring could be "order-made" to effectively change the coaptation length in all parts of the mitral valve post-deformation via intraoperative heating.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 17K10719

The mechanism and function of astrocytes in ischemic spinal cord injury in rabbit
Grants-in-Aid for Scientific Research(基盤研究(B))
2008 - 2010
椎谷 紀彦, Satoru WAKASA, Norihiko SHIIYA
Spinal cord injury is one of the disastrous complications after surgical repair of thoracoabdominal aortic aneurysm and remains to be eliminated. We investigated the role of astrocytes in the spinal cord injury after transient spinal cord ischemia to elucidate whether the astrocyte would be a target for prevention of spinal cord injury. In the rabbit model, we demonstrated the significant inverse correlation between the activity of astrocytes and number of intact motor neurons. Furthermore, a concentration of arachidonic adid significantly correlated with the activity of astrocytes.
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 北海道大学, Principal investigator, Competitive research funding, 20390362