Hosoda Mitsuchika
| Hokkaido University Hospital Surgery | Assistant Professor |
Last Updated :2025/06/07
■Researcher basic information
Researchmap personal page
Home Page URL
J-Global ID
Educational Organization
- Master's degree program, Graduate School of Medicine
- Doctoral (PhD) degree program, Graduate School of Medicine
■Career
■Research activity information
Papers
- 乳癌術後23年目に肺の小結節を指摘され,2年の経過を経て肺転移と診断された1例
荒町 優香里, 細田 充主, 小金澤 千夏, 守谷 結美, 羽田 光輝, 押野 智博, 竹中 淳規, 加藤 扶美, 高橋 將人
北海道外科雑誌, 69, 1, 51, 54, 北海道外科学会, Jun. 2024
Japanese - A Case of Pneumothorax Required Surgical Treatment as a Complication of Paclitaxel with Bevacizumab Treatment
Yumi Moriya, Tomohiro Oshino, Mitsuchika Hosoda, Karin Shikishima, Shun Miura, Jun Muto, Tatsuya Kato, Masato Takahashi
Case Reports in Oncology, 16, 1, 797, 802, S. Karger AG, 04 Sep. 2023
Scientific journal, A 63-year-old woman had a history of neoadjuvant chemotherapy, mastectomy, and adjuvant endocrine therapy for 5 years before being diagnosed with recurrent lesions involving the right anterior chest wall, multiple lymph nodes, and pulmonary metastases. The patient was subsequently initiated on a paclitaxel and bevacizumab regimen. During this treatment, the patient complained of palpitations and malaise. Chest radiography revealed a left pneumothorax. Despite attempts at conservative treatment, the pneumothorax did not improve and a thoracoscopic approach was required. One of the metastatic tumors in the left lower lobe appeared to rupture, and this area was estimated to be the cause of air leak. The tumor was covered with a tissue seal sheet, and the patient’s condition improved with no recurrence of pneumothorax. This case highlights the importance of early conversion to surgical treatment when conservative treatment for pneumothorax is unresponsive due to the potential side effects of bevacizumab. The findings of this case report may be of interest to oncologists, pulmonologists, and other healthcare professionals involved in the care of patients with breast cancer and pulmonary metastases who are undergoing bevacizumab chemotherapy. - Associations in tumor infiltrating lymphocytes between clinicopathological factors and clinical outcomes in estrogen receptor-positive/human epidermal growth factor receptor type 2 negative breast cancer.
Yuichiro Miyoshi, Tadahiko Shien, Akiko Ogiya, Naoko Ishida, Kieko Yamazaki, Rie Horii, Yoshiya Horimoto, Norikazu Masuda, Hiroyuki Yasojima, Touko Inao, Tomofumi Osako, Masato Takahashi, Nobumoto Tomioka, Yumi Wanifuchi-Endo, Mitsuchika Hosoda, Hiroyoshi Doihara, Hiroko Yamashita
Oncology letters, 17, 2, 2177, 2186, Feb. 2019, [International Magazine]
English, Scientific journal, The value of assessing tumor infiltrating lymphocytes (TILs) in estrogen receptor (ER) positive/human epidermal growth factor receptor type 2 (HER2) negative breast cancer has yet to be determined. In the present study, a total of 184 cases with early distant recurrence detected within 5 years following the primary operation, 134 with late distant recurrence diagnosed following 5 years or longer and 321 controls without recurrence for >10 years following starting the initial treatment for ER-positive/HER2 negative breast cancer, registered in 9 institutions, were analyzed. The distributions of TILs and their clinical relevance were investigated. TIL distributions did not differ significantly among the early, late and no recurrence groups, employing a 30% cut-off point as a dichotomous variable. In those who had received adjuvant chemotherapy as well as endocrine therapy, a trend toward higher TIL proportions was detected when the early recurrence group was compared with the no recurrence group employing the 30% cut-off point (P=0.064). The TIL distributions were significantly associated with nodal metastasis (P=0.004), ER status (P=0.045), progesterone receptor (PgR) status (P=0.002), tumor grade (P=0.021), and the Ki67 labeling index (LI) (P=0.002) in the no recurrence group and with the Ki67 LI in the recurrence groups (P=0.002 in early recurrence group, P=0.023 in late recurrence group). High TIL distributions also predicted shorter survival time following the detection of recurrence (P=0.026). However, these prognostic interactions were not significant in multivariate analysis (P=0.200). The present retrospective study demonstrated no significant interaction between TIL proportions and the timing of recurrence. However, higher TIL proportions were observed in breast cancer patients with aggressive biological phenotypes, which tended to be more responsive to chemotherapy. The clinical relevance of stromal TILs for identifying patients who would likely benefit from additional therapies merits further investigation in a larger patient population. - Post-relapse survival in patients with the early and late distant recurrence in estrogen receptor-positive HER2-negative breast cancer
Akiko Ogiya, Kieko Yamazaki, Rie Horii, Tadahiko Shien, Yoshiya Horimoto, Norikazu Masuda, Touko Inao, Mitsuchika Hosoda, Naoko Ishida, Tomofumi Osako, Masato Takahashi, Yumi Endo, Yuichiro Miyoshi, Hiroyuki Yasojima, Nobumoto Tomioka, Hiroko Yamashita
BREAST CANCER, 24, 3, 473, 482, May 2017
English, Scientific journal - Clinicopathological factors predicting early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer
Hiroko Yamashita, Akiko Ogiya, Tadahiko Shien, Yoshiya Horimoto, Norikazu Masuda, Touko Inao, Tomofumi Osako, Masato Takahashi, Yumi Endo, Mitsuchika Hosoda, Naoko Ishida, Rie Horii, Kieko Yamazaki, Yuichiro Miyoshi, Hiroyuki Yasojima, Nobumoto Tomioka
BREAST CANCER, 23, 6, 830, 843, Nov. 2016
English, Scientific journal - Fulvestrant 500 mg in postmenopausal patients with metastatic breast cancer: the initial clinical experience
Naoko Ishida, Kazuhiro Araki, Takehiko Sakai, Kokoro Kobayashi, Takayuki Kobayashi, Ippei Fukada, Mitsuchika Hosoda, Mitsugu Yamamoto, Kazuomi Ichinokawa, Shunji Takahashi, Takuji Iwase, Yoshinori Ito, Hiroko Yamashita
BREAST CANCER, 23, 4, 617, 623, Jul. 2016, [Peer-reviewed]
English, Scientific journal - Differences in expression of the cancer stem cell marker aldehyde dehydrogenase 1 among estrogen receptor-positive/human epidermal growth factor receptor type 2-negative breast cancer cases with early, late, and no recurrence
Yuichiro Miyoshi, Tadahiko Shien, Akiko Ogiya, Naoko Ishida, Kieko Yamazaki, Rie Horii, Yoshiya Horimoto, Norikazu Masuda, Hiroyuki Yasojima, Touko Inao, Tomofumi Osako, Masato Takahashi, Nobumoto Tomioka, Yumi Endo, Mitsuchika Hosoda, Hiroyoshi Doihara, Shinichiro Miyoshi, Hiroko Yamashita
BREAST CANCER RESEARCH, 18, Jul. 2016, [Peer-reviewed]
English, Scientific journal - Differences in morphological features and minimum apparent diffusion coefficient values among breast cancer subtypes using 3-tesla MRI.
Fumi Kato, Kohsuke Kudo, Hiroko Yamashita, Jeff Wang, Mitsuchika Hosoda, Kanako C Hatanaka, Rie Mimura, Noriko Oyama-Manabe, Hiroki Shirato
European journal of radiology, 85, 1, 96, 102, Jan. 2016, [International Magazine]
English, Scientific journal - Earlier and better high-resolution single breast imaging during bilateral breast dynamic scans at 3-T MRI: comparison with post dynamic high-resolution imaging.
Fumi Kato, Noriko Oyama-Manabe, Yusuke Sakuhara, Suzuko Mito, Masato Takahashi, Tetsuro Sakamoto, Mitsuchika Hosoda, Satoshi Terae, Hiroki Shirato
Breast cancer (Tokyo, Japan), 22, 5, 475, 9, Sep. 2015, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, BACKGROUND: Breast MRI protocols have been improved by using a combination of dynamic scans for bilateral breasts and high-resolution imaging for a single breast which can be obtained during dynamic scans by recent technological advances. The purpose of this study was to compare high-resolution imaging during dynamic scans (HR-intra) with high-resolution imaging obtained post dynamic scans (HR-post). METHODS: Fifty-five women with pathologically proven breast cancer who underwent breast dynamic scans at 3-T MRI from February to September 2009 were enrolled in this study. Tumoral contrasts to the background breast tissue were compared by three radiologists independently in a blinded fashion. Results of visual assessment were categorized into three groups as follows: HR-intra being better (IB), equal (E), and HR-post being better (PB). The contrast to noise ratio (CNR) of the tumor and the signal to noise ratio of the normal breast gland (SNR) were compared between HR-intra and HR-post. RESULTS: Two patients were excluded because of poor MR imaging quality. Three radiologists separately categorized 64.2, 79.2, and 77.4 % of lesions as IB. The CNR of the tumor of HR-intra (mean ± SD = 6.9 ± 4.0) was significantly higher than that of HR-post (6.0 ± 3.7, p < 0.0001). The SNR of the normal breast gland of HR-intra (9.5 ± 1.7) was significantly lower than that of HR-post (10.0 ± 1.9, p < 0.0001). CONCLUSION: HR-intra during dynamic MRI provided earlier and better tumor to normal breast gland contrast than HR-post. - 乳腺 乳がんホルモン療法とその問題点 エストロゲンレセプター陽性乳癌における早期再発、晩期再発症例の検討
山下 啓子, 荻谷 朗子, 石田 直子, 細田 充主, 枝園 忠彦, 三好 雄一郎, 堀本 義哉, 増田 慎三, 八十島 宏行, 稲尾 瞳子, 大佐古 智文, 高橋 將人, 富岡 伸元, 遠藤 友美, 堀井 理絵
日本癌治療学会誌, 50, 3, 362, 362, (一社)日本癌治療学会, Sep. 2015
Japanese - ER陽性HER2陰性乳癌における再発時期予測因子としての腫瘍浸潤リンパ球の意義の検討
三好 雄一郎, 枝園 忠彦, 荻谷 朗子, 石田 直子, 細田 充主, 堀本 義哉, 増田 慎三, 八十島 宏行, 稲尾 瞳子, 大佐古 智文, 高橋 將人, 富岡 伸元, 遠藤 友美, 堀井 理絵, 山下 啓子
日本癌治療学会誌, 50, 3, 556, 556, (一社)日本癌治療学会, Sep. 2015
Japanese - Prognostic significance of pathologic complete response and Ki67 expression after neoadjuvant chemotherapy in breast cancer
Tatsuya Yoshioka, Mitsuchika Hosoda, Mitsugu Yamamoto, Kazunori Taguchi, Kanako C. Hatanaka, Emi Takakuwa, Yutaka Hatanaka, Yoshihiro Matsuno, Hiroko Yamashita
BREAST CANCER, 22, 2, 185, 191, Mar. 2015
English, Scientific journal - 変異p53蛋白発現がアロマターゼ阻害剤投与後再発乳癌症例の予後に及ぼす影響の検討
山本 貢, 石田 直子, 市之川 一臣, 細田 充主, 山下 啓子, 畑中 佳奈子, 高桑 恵美, 畑中 豊, 松野 吉宏
北海道外科雑誌, 59, 2, 221, 221, 北海道外科学会, Dec. 2014
Japanese - Prognostic significance of pre-treatment neutrophil: lymphocyte ratio in Japanese patients with breast cancer.
Kiichiroh Nakano, Mitsuchika Hosoda, Mitsugu Yamamoto, Hiroko Yamashita
Anticancer research, 34, 7, 3819, 24, Jul. 2014, [Peer-reviewed], [International Magazine]
English, Scientific journal - 2013年度日本乳癌学会班研究中間報告 晩期再発乳癌の生物学的特徴と予測因子に関する研究
山下 啓子, 稲尾 瞳子, 荻谷 朗子, 枝園 忠彦, 堀本 義哉, 増田 慎三, 大佐古 智文, 高橋 將人, 遠藤 友美, 細田 充主
日本乳癌学会総会プログラム抄録集, 22回, 227, 227, (一社)日本乳癌学会, Jul. 2014
Japanese - Differential expression of progesterone receptor, FOXA1, GATA3, and p53 between pre- and postmenopausal women with estrogen receptor-positive breast cancer
Hosoda Mitsuchika, Yamamoto Mitsugu, Nakano Kiichiroh, Hatanaka Kanako C., Takakuwa Emi, Hatanaka Yutaka, Matsuno Yoshihiro, Yamashita Hiroko
Breast Cancer Research and Treatment, 144, 2, 249, 261, Springer, Apr. 2014
English, Estrogen receptor (ER) is essential for estrogendependent growth, and its level of expression is considered a crucial determinant of response to endocrine therapy and prognosis in ER-positive breast cancer. On the other hand, the clinical role of progesterone receptor (PgR) in ER-positive breast cancer remains controversial, although testing of PgR by immunohistochemistry (IHC) has become routine. Recent studies indicated that plasma estradiol levelswere related to the expression levels of estrogen-responsive genes in ER-positive breast cancer tissues in both pre- and postmenopausal women. In this study, we analyzed the expression levels of strogenresponsive genes (PgR and TFF1), a progesterone-responsive gene (RANKL), ER-related genes (FOXA1 and GATA3), HER2, Ki67 and p53 in ER-positive, HER2-negative breast cancer tissues by IHC. Correlations between the expression levels of these molecular markers and clinicopathological factors, including prognosis, were compared between pre- and postmenopausal women. Serum levels of estrone, estradiol, progesterone, and testosterone were also measured. Expression levels of PgR, TFF1, RANKL, and GATA3 were significantly higher in premenopausal women than in postmenopausal women. Serum estradiol levels were positively correlated with Ki67 labeling index (LI) in premenopausal women, but not in postmenopausal women. High expression of FOXA1 and GATA3 was significantly associated with improved diseasefreesurvival in premenopausal women, but not in postmenopausal women, whereas high expression of PgR and low expression of p53 were significantly correlated with the improved disease-free survival in postmenopausalwomen, but not in premenopausalwomen.Moreover, the best cutoff pointsof Ki67 LI for disease-free survival were 30 % for premenopausal women and 14 % for postmenopausal women.Expression levels of ER, TFF1, and RANKL were not associated with the disease-free survival in either pre- or postmenopausal women. Our results suggest that the mechanisms of development and estrogen-dependent growth ofER-positive breast cancer might differ according to menopausal status. - p53 accumulation is a strong predictor of recurrence in estrogen receptor-positive breast cancer patients treated with aromatase inhibitors
Mitsugu Yamamoto, Mitsuchika Hosoda, Kiichiroh Nakano, Shusheng Jia, Kanako C. Hatanaka, Emi Takakuwa, Yutaka Hatanaka, Yoshihiro Matsuno, Hiroko Yamashita
CANCER SCIENCE, 105, 1, 81, 88, Jan. 2014, [Peer-reviewed]
English, Scientific journal - 乳房温存術後、残存乳房照射後にpost radiation sarcomaを生じた1例
坂本 譲, 細田 充主, 山本 貢, 田口 和典, 山下 啓子, 武冨 紹信
北海道外科雑誌, 58, 1, 76, 76, 北海道外科学会, Jun. 2013, [Peer-reviewed]
Japanese - A CASE OF PRIMARY HYPERPARATHYROIDISM TREATED DURING PREGNANCY
ISHIGURO Yui, YAMAMOTO Mitugu, HOSODA Mitsuchika, TAGUCHI Kazunori, TAKAHASHI Hiromasa
The journal of the Japanese Practical Surgeon Society, 73, 8, 1882, 1886, Japan Surgical Association, 25 Aug. 2012
Japanese, Hyperparathyroidism during pregnancy is very rare but is associated with high rates of miscarriage, stillbirth, premature birth and neonatal tetany. A 38-year-old woman developed a slight fever and felt unwell ; hypercalcemia with an elevated intact PTH was detected. She was diagnosed as having primary hyperparathyroidism induced by parathyroid hyperplasia ; tumor involving both lower parathyroid glands was detected on ultrasonography and 99mTc-MIBI scintigraphy. The patient refused immediate surgery. Then, 21 months later, in the 24th week of pregnancy, she underwent total parathyroidectomy with intramuscular autotransplantation of parathyroid tissue and safely gave birth to a baby girl 4 months later ; currently, the patient and her daughter are both healthy with normal serum calcium levels 16 months postoperatively. In pregnant women the serum calcium level is usually at the lower limit. Therefore primary hyperparathyroidism should be considered in pregnant women with hypercalcemia. Surgery is safe to do in the second trimester of pregnancy. - 著明な高Ca血症をきたした巨大副甲状腺腺腫の1例
松澤文彦, 山本貢, 細田充主, 田口和典, 高橋弘昌, 松野吉宏
日本臨床外科学会雑誌, 73, 6, 1600, 25 Jun. 2012
Japanese - A CASE OF POLYMYOSITIS WITH BREAST CANCER AND GASTRIC CANCER
YAMAMOTO Mitsugu, HONMA Shigenori, HOSODA Mitsuchika, TAKAHASHI Norihiko, TAGUCHI Kazunori, TAKAHASHI Hiromasa
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association), 73, 5, 1307, 1310, 25 May 2012
Japanese - 乳房内出血にて緊急手術を要したadenosquamous carcinomaの1例
松澤 文彦, 旭 よう, 山本 貢, 細田 充主, 田口 和典, 高橋 弘昌, 藤堂 省, 藤田 裕美, 久保田 佳奈子
日本臨床外科学会雑誌, 72, 4, 1071, 1071, 日本臨床外科学会, Apr. 2011
Japanese - 異所性縦隔内甲状腺腫の1例
大畑 多嘉宣, 大高 和人, 山田 健司, 細田 充主, 高橋 將人, 高橋 弘昌, 藤堂 省
北海道外科雑誌, 55, 1, 75, 75, 北海道外科学会, Jun. 2010
Japanese - Comparative studies of paclitaxel injection [SAWAI] and Taxol® injection on pharmacokinetics in dogs and in vitro/vivo antitumor activities
Masato Takahashi, Mitsuchika Hosoda, Hiromasa Takahashi, Satoru Todo
Japanese Journal of Cancer and Chemotherapy, 37, 9, 1699, 1706, Japanese Journal of Cancer and Chemotherapy Publishers Inc., 2010
Japanese, Scientific journal - 甲状腺低分化癌の1例
旭 よう, 高橋 將人, 鈴木 徹平, 若山 顕治, 細田 充主, 高橋 弘昌, 藤堂 省
北海道外科雑誌, 54, 1, 37, 40, 北海道外科学会, Jun. 2009
Japanese - 乳腺mucocele-like tumorの2例
坂谷 慈, 長津 明久, 蔵谷 大輔, 細田 充主, 高橋 将人, 高橋 弘昌, 藤堂 省
北海道外科雑誌, 53, 1, 111, 111, 北海道外科学会, Jun. 2008, [Peer-reviewed]
Japanese - 甲状腺低分化癌の1例
旭 よう, 鈴木 徹平, 若山 顕治, 細田 充主, 高橋 將人, 高橋 弘昌, 久保田 佳奈子, 伊藤 智雄, 藤堂 省
日本臨床外科学会雑誌, 68, 9, 2420, 2420, 日本臨床外科学会, Sep. 2007
Japanese - 緊急手術を要した巨大乳腺扁平上皮癌の1例
渡辺 正明, 細田 充主, 寺崎 康展, 高橋 將人, 高橋 弘昌, 藤堂 省, 伊藤 智雄, 田口 和典, 高田 尚幸
北海道外科雑誌, 51, 2, 77, 77, 北海道外科学会, Dec. 2006
Japanese - Negative autoregulation of p73 and p53 by ΔNp73 in regulating differentiation and survival of human neuroblastoma cells
Takahito Nakagawa, Masato Takahashi, Toshinori Ozaki, Ken-Ichi Watanabe, Shunji Hayashi, Mitsuchika Hosoda, Satoru Todo, Akira Nakagawara
Cancer Letters, 197, 1-2, 105, 109, Elsevier Ireland Ltd, 18 Jul. 2003
English, International conference proceedings - Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function
Ken-Ichi Watanabe, Toshinori Ozaki, Takahito Nakagawa, Kou Miyazaki, Masato Takahashi, Mitsuchika Hosoda, Syunji Hayashi, Satoru Todo, Akira Nakagawara
Journal of Biological Chemistry, 277, 17, 15113, 15123, 26 Apr. 2002
English, Scientific journal
Other Activities and Achievements
- 膵頭部低悪性度腫瘍に対する全胆道・十二指腸温存膵頭部実質全切除術の有用性
上村 志臣, 細田 充主, 馬場 基, 石田 直子, 山下 啓子, 平野 聡, 柴田 有花, 北海道外科雑誌, 61, 2, 194, 194, Dec. 2016
北海道外科学会, Japanese - A CASE OF BREAST CANCER WITH POLYOSTOTIC FIBROUS DYSPLASIA THAT WAS INDISTINGUISHABLE FROM MULTIPLE BONE METASTASES
河北一誠, 河北一誠, 石田直子, 馬場基, 細田充主, 武冨紹信, 山下啓子, 日本臨床外科学会雑誌, 77, 8, 1907‐1911, 25 Aug. 2016
Japanese - 線維性骨異形成を合併し多発骨転移との鑑別に苦慮した早期乳癌の一例
河北一誠, 石田直子, 萩尾加奈子, 馬場基, 細田充主, 山下啓子, 武冨紹信, 北海道外科雑誌, 61, 1, 102, 20 Jun. 2016
Japanese - A case of postmenopausal breast cancer for which a pathological complete response was achieved through preoperative endocrine therapy
柴田泰洋, 柴田泰洋, 細田充主, 山本貢, 市之川一臣, 石田直子, 武冨紹信, 山下啓子, 北海道外科雑誌, 61, 1, 62‐66, 20 Jun. 2016
Japanese - 右乳癌、子宮体癌の重複癌に対し、同時切除を行ったCowden症候群の1例
上村 志臣, 細田 充主, 馬場 基, 石田 直子, 山下 啓子, 平野 聡, 柴田 有花, 北海道外科雑誌, 61, 1, 103, 103, Jun. 2016
北海道外科学会, Japanese - 3T乳腺MRIにおける拡散尖度画像を用いた浸潤性乳癌の評価 バイオマーカーおよび腋窩リンパ節転移との比較
加藤 扶美, 工藤 與亮, 藤原 太郎, Wang Jeff, 杉森 博行, 山下 啓子, 細田 充主, 真鍋 徳子, 三村 理恵, 白土 博樹, 日本乳癌学会総会プログラム抄録集, 24回, 250, 250, Jun. 2016
(一社)日本乳癌学会, Japanese - Prognostic value of aldehyde dehydrogenase 1 (ALDH1) and tumor infiltrating lymphocytes (TIL) to predict the late recurrence in ER positive, HER2 negative breast cancer
Y. Miyoshi, T. Shien, A. Ogiya, N. Ishida, K. Yamazaki, R. Horii, Y. Horimoto, N. Masuda, H. Yasojima, T. Inao, T. Osako, M. Takahashi, N. Tomioka, K. Hagio, Y. Endo, M. Hosoda, H. Yamashita, CANCER RESEARCH, 76, Feb. 2016
English, Summary international conference - 3T乳腺MRIにおける拡散尖度画像の検討
加藤 扶美, 工藤 與亮, 三村 理恵, 藪崎 哲史, 坂本 圭太, 宮本 憲幸, 真鍋 徳子, 藤原 太郎, 杉森 博行, 山下 啓子, 細田 充主, Wang Jeff, 白土 博樹, Japanese Journal of Radiology, 34, Suppl., 13, 13, Feb. 2016
(公社)日本医学放射線学会, Japanese - 造影超音波検査による乳癌術前化学療法効果判定の有用性
佐藤 恵美, 西田 睦, 工藤 悠輔, 井上 真美子, 表原 里実, 堀江 達則, 岩井 孝仁, 加藤 扶美, 細田 充主, 畑中 佳奈子, 山下 啓子, 超音波検査技術, 40, 6, 637, 648, Dec. 2015
(一社)日本超音波検査学会, Japanese - 当院における遺伝性乳がん・卵巣がん症候群の遺伝カウンセリングの現状
柴田 有花, 細田 充主, 三田村 卓, 山田 崇弘, 矢部 一郎, 山下 啓子, 三田村 卓, 山田 崇弘, 渡利 英道, 櫻木 範明, 炭山 峰華, 北海道外科雑誌, 60, 2, 231, 231, Dec. 2015
北海道外科学会, Japanese - A CASE OF MYELOID SARCOMA OF THE BREAST
柏倉さゆり, 柏倉さゆり, 山本貢, 細田充主, 三橋智子, 武冨紹信, 山下啓子, 日本臨床外科学会雑誌, 76, 7, 1567, 1570, 25 Jul. 2015
Japanese - 造影超音波検査による乳癌腋窩リンパ節転移診断能の検討
佐藤 恵美, 西田 睦, 工藤 悠輔, 井上 真美子, 表原 里実, 堀江 達則, 岩井 孝仁, 加藤 扶美, 細田 充主, 畑中 佳奈子, 山下 啓子, 超音波検査技術, 40, Suppl., S177, S177, May 2015
(一社)日本超音波検査学会, Japanese - 造影超音波が乳腺診療に何をもたらすのか? 4D造影超音波検査による乳癌の乳管内進展診断
佐藤 恵美, 西田 睦, 工藤 悠輔, 表原 里実, 堀江 達則, 岩井 孝仁, 加藤 扶美, 細田 充主, 菅野 宏美, 山下 啓子, 乳腺甲状腺超音波医学, 4, 2, 129, 129, Apr. 2015
(一社)日本乳腺甲状腺超音波医学会, Japanese - 造影超音波が乳腺診療に何をもたらすのか? 4D造影超音波検査による乳癌の乳管内進展診断
佐藤 恵美, 西田 睦, 工藤 悠輔, 表原 里実, 堀江 達則, 岩井 孝仁, 加藤 扶美, 細田 充主, 菅野 宏美, 山下 啓子, 超音波医学, 42, Suppl., S343, S343, Apr. 2015
(公社)日本超音波医学会, Japanese - 局所コントロール不能となり準緊急にて乳房切除術を施行したHER2陽性局所進行乳癌の1例
石川倫啓, 市之川一臣, 石田直子, 山本貢, 細田充主, 山下啓子, 武冨紹信, 菅野宏美, 北海道外科雑誌, 59, 2, 194, 20 Dec. 2014
Japanese - Surgical treatment for breast cancer Recent changes in surgical treatment of breast cancer and sentinel lymph node biopsy
山下 啓子, 細田 充主, 山本 貢, 北海道外科雑誌, 59, 2, 10, 14, Dec. 2014
北海道外科学会, Japanese - Post-radiation sarcoma after radiofrequency ablation and radiotherapy for breast cancer-a case report
坂本譲, 細田充主, 三橋智子, 山本貢, 田口和典, 武冨紹信, 山下啓子, 北海道外科雑誌, 59, 1, 44, 47, 20 Jun. 2014
Japanese - 当科におけるOncotypeDX施行症例のrecurrence score(RS)と臨床病理学的因子の検討
正司裕隆, 細田充主, 市之川一臣, 中野基一郎, 山本貢, 山下啓子, 武冨紹信, 亀田博, 北海道外科雑誌, 59, 1, 82, 20 Jun. 2014
Japanese - HER2陰性乳癌におけるソナゾイド造影超音波検査所見と乳癌subtypeの検討
佐藤 恵美, 西田 睦, 工藤 悠輔, 表原 里実, 堀江 達則, 岩井 孝仁, 加藤 扶美, 細田 充主, 山下 啓子, 畑中 佳奈子, 超音波医学, 41, Suppl., S643, S643, Apr. 2014
(公社)日本超音波医学会, Japanese - OP-094-6 ER陽性乳癌におけるER関連蛋白,Ki67,p53蛋白発現の閉経前後での異なる役割について(OP-094 乳腺 ホルモン・放射線・分子標的治療,一般演題,第114回日本外科学会定期学術集会)
細田 充主, 山本 貢, 中野 基一郎, 山下 啓子, 日本外科学会雑誌, 115, 2, 482, 482, 05 Mar. 2014
一般社団法人日本外科学会, Japanese - PS-219-7 エストロゲンレセプター陽性乳癌における血清性ホルモン濃度と臨床病理学的因子との相関(PS-219 乳腺 内分泌療法,ポスターセッション,第114回日本外科学会定期学術集会)
金沢 亮, 細田 充主, 山本 貢, 中野 基一郎, 武冨 紹信, 山下 啓子, 日本外科学会雑誌, 115, 2, 1013, 1013, 05 Mar. 2014
一般社団法人日本外科学会, Japanese - エストロゲンレセプター陽性乳癌における血清性ホルモン濃度と臨床病理学的因子との相関
金沢亮, 細田充主, 山本貢, 中野基一郎, 武冨紹信, 山下啓子, 日本外科学会雑誌, 115, 1013, 05 Mar. 2014
Japanese - A CASE OF RECURRENT BREAST CANCER WITH CARCINOMATOUS MENINGITIS AT 10 YEARS AFTER RESECTION, MANIFESTED BY RAPID EXCERBATION
WAKIZAKA KAZUKI, WAKIZAKA KAZUKI, TAGUCHI KAZUNORI, HOSODA MICHITSUKA, YAMAMOTO MITSUGU, TAKETOMI AKINOBU, YAMASHITA HIROKO, 日本臨床外科学会雑誌, 74, 5, 1208, 1211, 25 May 2013
Japanese - PS-135-5 乳癌組織におけるホルモンレセプターの発現量の臨床的意義に関する検討(PS ポスターセッション,第113回日本外科学会定期学術集会)
細田 充主, 山本 貢, 田口 和典, 山下 啓子, 日本外科学会雑誌, 114, 2, 706, 706, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - SY-10-3 エストロゲンレセプター陽性乳癌の発症メカニズムと生物学的特性の解明に関する研究(SY シンポジウム,第113回日本外科学会定期学術集会)
山下 啓子, 遠山 竜也, 吉本 信保, 遠藤 友美, 細田 充主, 山本 貢, 田口 和典, 日本外科学会雑誌, 114, 2, 135, 135, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - Co-overexpression of GEP100 With EGFR Correlates With Early Recurrence After Breast Conservation Therapy (BCT)
R. Kinoshita, J. Nam, M. Hosoda, C. Kubota K, M. Tanino, A. Hashimoto, Y. M. Ito, S. Tanaka, H. Sabe, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 84, 3, S227, S228, Nov. 2012
English, Summary international conference - A CASE OF PRIMARY NEUROENDOCRINE CARCINOMA OF THE BREAST
MATSUZAWA Fumihiko, YAMAMOTO Mitsugu, HOSODA Mitsuchika, TAGUCHI Kazunori, TAKAHASHI Hiromasa, 日本臨床外科学会雑誌 = The journal of the Japan Surgical Association, 73, 6, 1355, 1360, 25 Jun. 2012
Japanese - A case of aberrant mediastinal goiter
大畑 多嘉宣, 細田 充主, 高橋 將人, 北海道外科雑誌, 57, 1, 40, 43, Jun. 2012
北海道外科学会, Japanese - A case of giant parathyroid adenoma with remarkable hypercalcemia
細田 充主, 松澤 文彦, 山本 貢, 日本内分泌・甲状腺外科学会雑誌 = Official journal of the Japan Association of Endocrine Surgeons and the Japanese Society of Thyroid Surgery, 29, 2, 157, 161, Jun. 2012
日本内分泌外科学会 ; 2012-, Japanese - 北海道大学病院における乳房温存療法の治療成績
木下 留美子, 清水 伸一, 西岡 健太郎, 原田 慶一, 小野寺 俊輔, 田口 大志, 細田 充主, 田口 和典, 高橋 弘昌, 白土 博樹, 日本医学放射線学会学術集会抄録集, 71回, S318, S318, Feb. 2012
(公社)日本医学放射線学会, Japanese - Surgical indications for nodular goiter excluding papillary carcinoma
TAKAHASHI Hiromasa, HOSODA Mitsuchika, YAMAMOTO Mitsugu, TAGUCHI Kazunori, MATSUNO Yoshihiro, 内分泌外科 = Endocrine surgery, 28, 4, 245, 250, 30 Dec. 2011
Japanese - 乳癌・胃癌を合併した多発性筋炎の1例
山本貢, 本間重紀, 細田充主, 崎浜秀康, 高橋典彦, 田口和典, 片岡昭彦, 高橋弘昌, 竹内朗子, 久保田佳奈子, 松野吉宏, 北海道外科雑誌, 56, 2, 165, 165, 20 Dec. 2011
北海道外科学会, Japanese - A case of occult carcinoma of the thyroid which was found on the occasion of hoarseness caused by vagus nerve invasion by cervical lymph node metastases
SHIMADA Shingo, YAMAMOTO Mitsugu, HOSODA Mitsuchika, TAGUCHI Kazunori, TAKAHASHI Hiromasa, YAMADA Yousuke, TODO Satoru, 内分泌外科, 28, 3, 186, 190, Sep. 2011
(株)インターメルク, Japanese - A CASE REPORT OF INVASIVE CRIBRIFORM CARCINOMA OF THE BREAST
AIYAMA Takeshi, FUJITA Hiromi, HOSODA Mitsuchika, TAGUCHI Kazunori, TAKAHASHI Hiromasa, TODO Satoru, Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association), 72, 7, 1715, 1720, 25 Jul. 2011
Japanese - VW-1-7 乳癌ラジオ波治療の実際とその課題(VW1 ビデオワークショップ(1)乳癌に対するOncoplastic Surgery : 根治性と整容性を追究した乳癌手術の実際,第111回日本外科学会定期学術集会)
高橋 將人, 細田 充主, 高橋 弘昌, 柴崎 晋, 上徳 ひろみ, 渡邊 健一, 藤堂 省, 日本外科学会雑誌, 112, 1, 303, 303, 25 May 2011
一般社団法人日本外科学会, Japanese - A CASE OF MASTECTOMY FOR BREAST CANCER WITH RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA UNDER GENERAL ANESTHESIA
SHIMADA Shingo, YAMAMOTO Mitsugu, HOSODA Mitsuchika, TAGUCHI Kazunori, TAKAHASHI Hiromasa, TODO Satoru, Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association), 72, 1, 27, 31, 25 Jan. 2011
Epidermolysis bullosa is a rare disease which makes bullae in the skin and mucous membranes even by mild mechanical trauma. It is necessary for the patients to avoid stimulating the skin and mucous membranes during daily activities. Specially we must take care not to injure tracheal mucous membranes by endotracheal intubation during anesthesia and operation.
We report a case of successful mastectomy under general anesthesia using endotracheal intubation for a patient who had right breast cancer as well as recessive dystrophic epidermolysis bullosa. The patient was a 55-year-old female who had been treated at the department of dermatology in our hospital for recessive dystrophic epidermolysis bullosa since early childhood. She visited our surgical department because of a tumor of the right breast in June 2010. We diagnosed her as having right breast cancer, TisN0M0 Stage0, and performed operation under general anesthesia using endotracheal intubation. She was discharged from the hospital on 4th postoperative day without postoperative complications including dyspnea., Japan Surgical Association, Japanese - A CASE OF CHYLOUS FISTULA AFTER RIGHT MASTECTOMY WHICH WAS TREATED CONSERVATIVELY
EMOTO Shin, TAKAHASHI Masato, HOSODA Mitsuchika, TAKAHASHI Hiromasa, TODO Satoru, Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association), 71, 8, 1959, 1964, Aug. 2010
日本臨床外科学会, Japanese - 7.小児甲状腺びまん性硬化型乳頭癌の2例(第35回北海道小児がん研究会)
小野 仁, 細田 充主, 高橋 將人, 高橋 弘昌, 藤堂 省, 岡田 忠雄, 佐々木 文章, 小児がん : 小児悪性腫瘍研究会記録, 47, 2, 350, 350, 25 May 2010
日本小児がん学会, Japanese - VD-011-3 乳癌RFA治療 : 安全な治療適応決定のために(乳腺,一般ビデオ,第110回日本外科学会定期学術集会)
高橋 将人, 細田 充主, 高橋 弘昌, 松野 吉宏, 藤堂 省, 日本外科学会雑誌, 111, 2, 281, 281, 05 Mar. 2010
一般社団法人日本外科学会, Japanese - 乳房温存手術後接線照射における被照射腋窩リンパ節領域の検討
田口 大志, 清水 伸一, 木下 留美子, 白土 博樹, 高橋 弘昌, 高橋 將人, 細田 充主, 藤堂 省, 北海道外科雑誌, 54, 2, 188, 188, Dec. 2009
北海道外科学会, Japanese - THREE CASE REPORTS OF PRIMARY HYPERPARATHYROIDISM OCCURRING DURING PREGNANCY
YOKOO Hideki, TAKAHASHI Hiromasa, HOSODA Mitsuchika, TAKAHASHI Masato, SASAKI Fumiaki, TODO Satoru, Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association), 70, 6, 1614, 1619, 25 Jun. 2009
Parathyroidectomy was done in three patients with primary hyperparathyroidism during pregnancy. One case was diagnosed as primary hyperparathyroidism with hypercalcemia and had surgical treatment in the third trimester. The two other cases were diagnosed with neonatal tetany and had surgical treatment after delivery. Primary hyperparathyroidism during pregnancy is generally associated with a high risk of maternal morbidity, neonatal tetany, and fetal death. If hypercalcemia is detected, during pregnancy or neonatal tetany occurs, it is mandatory to rule out primary hyperparathyroidism., Japan Surgical Association, Japanese - ELASTOSONOGRAPHY OF 72 BREAST LESIONS
HOSODA Mitsuchika, TAKAHASHI Masato, TAKAHASHI Hiromasa, TODO Satoru, Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association), 70, 3, 645, 649, 25 Mar. 2009
Elastography, a non-invasive modality, provides objective information about tissue stiffness and can be used to diagnose breast tumor. However, the clinical usefulness of elastosonography is not yet clear.
To evaluate the diagnostic utility of elastography in breast tumors, the data of 71 women with 72 breast lesions evaluated using elastosonography (EUB-7500 : Hitachi Medical) from November 2006 to November 2007 were analyzed. The Tsukuba Elastography Score was used to assess the elastosonography results. There were 31 benign and 41 malignant lesions. The mean score of the benign lesions was 1.8±0.9, and the mean score of the malignant lesions was 3.7±1.3 (p<0.001). The sensitivity of elastography was 70.9%, and the specificity was 90.3%. B mode ultrasonography data obtained at the same time were also assessed ; the sensitivity of B mode was 97.6%, and specificity was 58.0%. The specificity of elastography was superior to B mode. The sensitivity of elastography was relatively higher for larger lesions, invasive carcinomas, and higher grade malignant tumors. It appears that elastosonography is very useful for diagnosing benign breast lesions and reducing the number of unnecessary biopsies., Japan Surgical Association, Japanese - HP-228-3 ステレオガイドマンモトーム生検442症例の検討(乳がん(画像診断2),ハイブリッドポスター,第109回日本外科学会定期学術集会)
高橋 將人, 細田 充主, 高橋 弘昌, 藤堂 省, 日本外科学会雑誌, 110, 2, 770, 770, 25 Feb. 2009
一般社団法人日本外科学会, Japanese - TWO CASES OF METAPLASTIC BREAST CARCINOMA
HOSODA Mitsuchika, TAKAHASHI Masato, TAKAHASHI Hiromasa, ITO Tomoo, TODO Satoru, Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association), 69, 10, 2479, 2484, 25 Oct. 2008
We report two cases of metaplastic breast carcinoma.
Case 1 : A 42-year-old woman who had undergone modified radical mastectomy for right breast cancer at the age of 25 presented with a firm mass in the left breast. Mammotome® biopsy revealed invasive carcinoma and left modified radical mastectomy was performed. Histological examination demonstrated metaplastic carcinoma showing spindle cells and cartilaginous metaplasia with ductal carcinoma. Case 2 : A 60-year-old woman was referred to our hospital because of a left breast mass and an axillary ulcer. Core biopsy revealed squamous cell carcinoma for which chemotherapy was unduccessful. Thus we performed modified radical mastectomy after irradiation. Histological examination demonstrated metaplastic carcinoma showing concomitance of ductal carcinoma and squamous cell carcinoma as well as osseous metaplasia. She died of local recurrence and multiple liver metastases 3 months after the operation.
Metaplastic breast carcinoma is a rare neoplasm of the breast. It has been reported to carry poor prognosis., Japan Surgical Association, Japanese - Cystic papillary carcinoma of the thyroid : Report of 4 cases
HOSODA Mitsuchika, WATANABE Ken-ichi, TAKAHASHI Masato, TAKAHASHI Hiromasa, ITO Tomoo, TODO Satoru, 内分泌外科 = Endocrine surgery, 25, 2, 127, 133, 30 Jun. 2008
Japanese - DP-110-3 早期乳癌に対するラジオ波熱凝固療法(RFA)(第108回日本外科学会定期学術集会)
高橋 將人, 細田 充主, 高橋 弘昌, 伊藤 智雄, 藤堂 省, 日本外科学会雑誌, 109, 2, 564, 564, 25 Apr. 2008
一般社団法人日本外科学会, Japanese - 無痛性甲状腺炎を契機に発見された甲状腺被包型乳頭癌の1例
島田 慎吾, 細田 充主, 高橋 將人, 高橋 弘昌, 伊藤 智雄, 藤堂 省, 北海道外科雑誌, 52, 2, 148, 152, Dec. 2007
北海道外科学会, Japanese - A case of giant squamous cell carcinoma of the breast excised in an emergency operation
渡辺 正明, 細田 充主, 高橋 將人, 北海道外科雑誌, 52, 1, 32, 36, Jun. 2007
北海道外科学会, Japanese - DP-015-3 早期乳癌に対するラジオ波熱凝固療法(RFA)の有用性を確認するための臨床研究(第107回日本外科学会定期学術集会)
高橋 將人, 細田 充主, 高橋 弘昌, 伊藤 智雄, 藤堂 省, 日本外科学会雑誌, 108, 2, 362, 362, 10 Mar. 2007
一般社団法人日本外科学会, Japanese - A CASE REPORT OF PAPILLARY THYROID CARCINOMA WITH A GIANT CYST REMAINING FOR 24 YEARS
NOGUCHI Takuro, TAKAHASHI Hiromasa, TAKAHASHI Masato, HOSODA Mitsuchika, SASAKI Ayami, TODO Satoru, Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association), 68, 1, 27, 30, 25 Jan. 2007
日本臨床外科学会, Japanese - Occult thyroid carcinoma detected by cervical lymph node metastases: a case report
寺崎 康展, 細田 充主, 高橋 將人, 北海道外科雑誌, 51, 2, 30, 34, Dec. 2006
北海道外科学会, Japanese - シスプラチン耐性獲得機構におけるp73の役割についての解析
林 俊治, 尾崎 俊文, 細田 充主, 中川 隆公, 渡邊 健一, 藤堂 省, 古川 龍彦, 秋山 伸一, 中川 原章, 日本外科学会雑誌, 107, 2, 669, 669, 05 Mar. 2006
一般社団法人日本外科学会, Japanese - 神経芽腫細胞のアポトーシス誘導過程におけるp73とユビキチンリガーゼUFD2aとの機能的相互作用(第105回日本外科学会定期学術集会)
細田 充主, 尾崎 俊文, 林 俊治, 宮崎 耕, 花本 尊之, 中川原 章, 中川 隆公, 渡邊 健一, 藤堂 省, 日本外科学会雑誌, 106, 0, 272, 272, 05 Apr. 2005
一般社団法人日本外科学会, Japanese - 蛋白質リン酸化酵素PKAによるp73の機能制御(第105回日本外科学会定期学術集会)
花本 尊之, 尾崎 俊文, 林 俊治, 細田 充主, 菊地 弘展, 藤堂 省, 中川原 章, 日本外科学会雑誌, 106, 0, 317, 317, 05 Apr. 2005
一般社団法人日本外科学会, Japanese - 癌抑制蛋白質ING1によるp53転写活性化能の制御
林 俊治, 尾崎 俊文, 細田 充主, 中川 隆公, 渡邊 健一, 藤堂 省, 中川原 章, 日本外科学会雑誌, 104, 0, 395, 396, 30 Apr. 2003
一般社団法人日本外科学会, Japanese - 酵母one-hybrid法によるΔNp73プロモーター活性を制御する因子の検索と機能解析
細田 充主, 中川 隆公, 渡邊 健一, 尾崎 俊文, 林 俊治, 藤堂 省, 中川 康章, 日本外科学会雑誌, 104, 0, 396, 396, 30 Apr. 2003
一般社団法人日本外科学会, Japanese - cDNAマイクロアレイを用いた乳がん発症モデル系におけるING1制御遺伝子群の大量解析
林 俊治, 高橋 將人, 関 直彦, 加藤 真樹, 中川 隆公, 渡邊 健一, 細田 充主, 尾崎 俊文, 中川 原章, 藤堂 省, 日本外科学会雑誌, 103, 0, 134, 134, 10 Mar. 2002
一般社団法人日本外科学会, Japanese - p73αカルボキシル末端領域結合蛋白質の機能解析
渡邊 健一, 尾崎 俊文, 中川 隆公, 高橋 将人, 林 俊治, 細田 充主, 宮崎 耕, 中川原 章, 藤堂 省, 日本外科学会雑誌, 103, 0, 188, 188, 10 Mar. 2002
一般社団法人日本外科学会, Japanese - DeltaNp73を標的としたp73のnegative auto-regulation
中川 隆公, 尾崎 俊文, 渡邊 健一, 高橋 将人, 細田 充主, 林 俊治, 宮崎 耕, 中川 原章, 藤堂 省, 日本外科学会雑誌, 103, 0, 524, 524, 10 Mar. 2002
一般社団法人日本外科学会, Japanese - 5. 腹腔鏡下摘出を行った縦隔奇形腫の 2 例(第 61 回 日本小児外科学会北海道地方会)
細田 充主, 皆川 のぞみ, 山本 浩史, 佐々木 文章, 藤堂 省, 森川 利昭, 日本小児外科学会雑誌, 36, 2, 359, 359, 20 Apr. 2000
特定非営利活動法人日本小児外科学会, Japanese - 5. 胸腔鏡下摘出術を行った縦隔奇形腫の 2 例(第 3 回日本小児内視鏡手術研究会)
細田 充主, 皆川 のぞみ, 山本 浩史, 佐々木 文章, 藤堂 省, 森川 利昭, 真弓 享久, 日本小児外科学会雑誌, 36, 2, 389, 389, 20 Apr. 2000
特定非営利活動法人日本小児外科学会, Japanese - 5.先天性食道狭窄症の1例(第54回日本小児外科学会北海道地方会)
細田 充主, 佐々木 伸, 川村 秀樹, 越前谷 勇人, 山本 浩史, 高橋 弘昌, 佐々木 文章, 内野 純一, 日本小児外科学会雑誌, 32, 4, 746, 747, 20 Jun. 1996
特定非営利活動法人日本小児外科学会, Japanese - 肝細胞癌(HCC)切除後肝不全に対し持続的血液浄化療法にも拘わらず,肝繊維化が急速に進行し死亡した1例(日本アフェレシス学会北海道アフェレシス研究会第15回学術集会抄録)
富岡 伸元, 松下 通明, 嶋村 剛, 中西 一彰, 羽田 力, 大久保 尚, 細田 充主, 仲 昌彦, 佐藤 直樹, 中島 保明, 宇根 良衛, 内野 純一, 日本アフェレシス学会雑誌, 15, 3, 327, 327, 1996
日本アフェレシス学会, Japanese
Research Themes
- Study on clinicopathological characteristics and predictive factors for breast cancer with late recurrence
Grants-in-Aid for Scientific Research
01 Apr. 2014 - 31 Mar. 2017
Yamashita Hiroko, ISHIDA NAOKO
We retrospectively collected data from ER-positive, HER2-negative breast cancer patients with early and late distant relapse and patients who remained relapse free for more than 10 years. A total of 223 patients with early distant recurrence and 149 patients with late distant recurrence of ER-positive, HER2-negative breast cancer who were given their initial treatment between 2000 and 2004 were registered. Clinicopathological factors and adjuvant therapies were compared among patients with early and late distant recurrence and patients without recurrence by menopausal status and age. Predictive factors for early and late distant recurrence were identified. Moreover, prognostic factors for post-relapse survival in patients with the early and late recurrence were analyzed.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 26461937 - Diagnostic bioimaging for acute cellular rejection using antibody probes in mouse liver transplantation
Grants-in-Aid for Scientific Research
2011 - 2012
MITSUCHIKA Hosoda, OZAKI Michitaka
We conducted this study to develop a new diagnostic method for allograft rejection in liver transplantation where infiltrating T-cells were quantified using antibody probes. We succeeded in inducing an acute cellular rejection in a mouse model of allogeneic liver transplantation. Immunohistologically, we confirmed that CD3 was strongly expressed on the infiltrating T-cells. However, a biological imaging after systemic injection of anti CD3 antibody probes could not detect the infiltrating T-cells. To deliver antibody probes to the infiltrating T-cells directly, we developed an extracorporeal perfusion machine for mouse liver and administered antibody probes to liver graft via the perfusion fluid. Even in this method, anti CD3 antibody probes could not detect the infiltrating T-cells.
Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 23659607 - Detection of circulating tumor cells in breast cancer utilizing new direct method and biological analysis
Grants-in-Aid for Scientific Research
2007 - 2009
TAKAHASI Masato
Exact identification of circulation tumor cells (CTC) brings the choice of patients who should take heavy treatment. As a result, Survival will be improved. At first, we confirmed the detection of very small number of breast cancer cells in blood by the isolation by size of epithelial tumor cells (ISET) method. The next, we compared the sensitivity of ISET method with that of quantitative real-time RT-PCR assay for the evaluation of CK-19 mRNA expression. The sensitivity of ISET was not comparable with those obtained using RT-PCR. Immunohistochemistry of ER, PgR, HER2 on the filter of ISET showed same behavior like the original cell lines. The DNA extracted from ISET-positive filter could detect the mutation of p53 using direct sequence method. HER-2 amplification could be measured by FISH analysis. Unfortunately none of 17 breast cancer samples from peripheral blood and bone marrow just before surgical operation, showed the presence of CTC cells on the filter of ISET method. Some devices for sensitivity improvement of ISET method should be required in the future.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 19591500 - Inhibition of severity of acute pancreatitis and MOF by a novel NF-kB inhibitior, DHMEQ.
Grants-in-Aid for Scientific Research
2007 - 2008
HOSODA Mitsuchika, TODO Satoru, MATSUSHITA Michiaki
セルレインによる急性膵炎モデルで、新規NF-kB選択的阻害剤DHMEQを用いて、重症化、多臓器不全の抑制効果について検討した。セルレイン膵炎を誘導することはできたが、DHMEQによる膵炎の抑制は血清学的にも、組織学的にも効果がなかった。そのため、多臓器不全モデルのセルレイン膵炎とLPSによる致死率モデルを検討したが、モデルの確立には至らなかった。また、膵炎の程度、多臓器障害の程度を血清、組織学的に評価したが、DHMEQによる抑制効果は認められなかった。
Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, 19790933
