Ohkuma Takeshi
| Faculty of Engineering Applied Chemistry Industrial Organic Chemistry | Specially Appointed Professor |
Last Updated :2025/06/07
■Researcher basic information
Degree
Researchmap personal page
Home Page URL
J-Global ID
Research Keyword
- Dual Catalysis
- Unsaturated Carbonyl Compound
- Unsaturated Ketone
- Combined Metal Catalyst
- Asymmetric Cyanation
- Allylic Alcohol
- Asymmetric Isomerization
- Box ligands
- Kinetic resolution
- Photocyclization
- Pd nanoparticles
- Cu complexes
- 不斉水素化
- 光学活性アルコール
- ルテニウム錯体
- ケトン
- エナンチオ選択性
- DPEN
- DAIPEN
- 反応機構
- XylBINAP
- 生理活性物質
- 触媒活性
- 単純ケトン類
- BINAP
- ルテニウム錯体触媒
- TolBINAP
- DMAPEN
- 1,4-ジアミン
- シアノヒドリン
- アルコール
- カルボニル選択性
- 1-テトラロン
- PICA
- 触媒的不斉合成
- IPHAN
- 金属錯体触媒
- LiCl
- アルデヒド
- ヘテロ原子置換ケトン
- 合成有機化学
- 有機金属化学
- Asymmetric Catalysis (4072)
- Organometallic Chemistry (4072)
- Synthetic Organic Chemistry (4602)
- Organometallic Chemistry
Research Field
Educational Organization
- Bachelor's degree program, School of Engineering
- Master's degree program, Graduate School of Chemical Sciences and Engineering
- Doctoral (PhD) degree program, Graduate School of Chemical Sciences and Engineering
■Career
Career
- Apr. 2013 - Present
北海道大学（大学院工学研究院 フロンティア化学教育研究センター）, センター長（兼任） - 2009 - Present
北海道大学 (大学院工学研究院 有機プロセス工学部門）, 教授 - Apr. 2016 - Mar. 2018
Hokkaido University, Graduate School of Chemical Sciences and Engineering, Deen - Jun. 2012 - Mar. 2013
北海道大学（大学院工学研究院 フロンティア化学教育研究センター）, 副センター長（兼任） - 2010
- Professor,Professor (Hokkaido University, Faculty of Chemical Process Engineering) - 2005 - 2009
同大学教授（大学院工学研究科 有機プロセス工学専攻） 教授 - 2005 - 2009
Professor,Professor (Hokkaido University, Division of Chemical Process Engineering) - 2004 - 2005
北海道大学教授 (大学院工学研究科 分子化学専攻) 教授 - 2004 - 2005
Professor,Professor (Hokkaido University, Division of Molecular Chemistry) - 2002 - 2004
同大学助教授 (物質科学国際研究センター 有機物質合成研究分野) 助教授 - 2002 - 2004
Associate Professor,Associate Professor (Nagoya University, Research Center for Materials Science) - 1996 - 2002
名古屋大学助教授 (大学院理学研究科 物質理学専攻) 助教授 - 1996 - 2002
Associate Professor,Associate Professor (Nagoya University, Chemistry Department) - 1992 - 1996
野依分子触媒プロジェクト研究員 (新技術事業団 (現 科学技術振興機構)) 研究員 - 1992 - 1996
Researcher,Molecular Catalysis Project Researcher (Japan Science and Technology Agency) - 1991 - 1992
博士研究員 (米国スタンフォード大学) 研究員 - 1991 - 1992
Researcher,Post Doctoral Researcher (Stanford University, USA) - 1988 - 1990
特別研究員 (日本学術振興会) 研究員 - 1988 - 1990
Researcher,Researcher (Japan Society for Promotion of Science)
Educational Background
- 1991, Nagoya University, 理学研究科, 博士課程後期課程, Japan
- 1991, Nagoya University, Graduate School, Division of Natural Science
- 1987, Keio University, Graduate School of Science and Technology, Japan
- 1987, Keio University, Graduate School, Division of Science and Engineering
- 1985, Keio University, Faculty of Science and Technology, Department of Chemistry, Japan
- 1985, Keio University, Faculty of Science and Engineering
Committee Memberships
- Mar. 2021 - Present
Catalysts, Editorial Board Member, Others - Feb. 2021 - Present
Synthetic Organic Chemistry Japan, kanji, Society - Apr. 2020 - Present
Frontier Chemistry Center (Division of Engineering, Hokkaido University), Responsible Person for NMR equipments - Apr. 2015 - Present
NEDO, Peer Reviewer, Government - Apr. 2013 - Present
Frontier Chemistry Center, Director, Others - 2010 - Present
万有札幌シンポジウム, 組織委員, Others - Mar. 2023 - Feb. 2025
日本化学会北海道支部, 監事, Society - Apr. 2021 - May 2024
Elsevier: Academic Press, Comprehensive Chirality 2nd Edition Volume Editor, Others - Apr. 2023 - Mar. 2024
応用化学部門・総合化学院, 代議員 - Apr. 2021 - Mar. 2023
Admission Center, Hokkaido University, Member - Apr. 2020 - Mar. 2023
The Society of Synthetic Organic Chemistry, Japan, International Prize Committee for "Ryoji Noyori Prize", Society - Mar. 2022 - Feb. 2023
Chemical Society of Japan (Hokkaido Branch), Chairman, Society - Apr. 2021 - Mar. 2022
Chemical Society of Japan, Reviewer - Apr. 2020 - Mar. 2022
Graduate School of Chemical Sciences and Engineering (Hokkaido University), Student Committee member - Feb. 2021 - Feb. 2022
Chemical Society of Japan (Hokkaido Branch), Vice Chairman, Society - Oct. 2020 - Sep. 2021
Applied Chemistry Course (Division of Engineering, Hokkaido University), Placement stuff - Aug. 2017 - Jul. 2021
JSPS, Peer Reviewer, Government - Apr. 2020 - Mar. 2021
Graduate School of Chemical Sciences and Engineering (Hokkaido University), representative - Apr. 2019 - Mar. 2021
日本化学会, 学会賞選考委員, Society - Apr. 2018 - Feb. 2021
有機合成化学協会, 代議員, Society - Feb. 2019 - Jan. 2021
有機合成化学協会 北海道支部, 支部長, Society - Apr. 2007 - Mar. 2020
高分解能核磁気共鳴装置研究室, 責任者, Others - May 2017 - May 2019
日本化学会, 本部理事, Society - Apr. 2017 - Mar. 2019
有機合成化学協会, 北海道支部副支部長, Society - Oct. 2015 - Sep. 2018
北海道大学触媒科学研究所, 評価委員会委員, Others - Apr. 2017 - Mar. 2018
有機合成化学区協会, 支部推薦委員会委員, Society - Apr. 2007 - Mar. 2018
有機合成化学協会, 北海道支部 常任幹事, Society - Apr. 2014 - Mar. 2015
北海道大学触媒化学研究センター, 協議委員会委員, Others - Apr. 2010 - Mar. 2011
北海道大学大学院工学研究院, 有機プロセス工学部門長, Others - 2007 - 2010
日本化学会, 北海道支部 環境安全担当幹事, Society - Apr. 2006 - Mar. 2007
北海道大学大学院工学研究科, 有機プロセス工学専攻長, Others - Apr. 2006 - Mar. 2007
北海道大学工学部, 応用化学コース長, Others - Apr. 2006 - Mar. 2007
北海道大学工学部, 応用理工系学科長, Others
■Research activity information
Awards
- Feb. 2025, The Society of Synthetic Organic Chemistry, Japan, The66th Synthetic Organic Chemistry Award, Japan
独自のルテニウム錯体触媒を用いる不斉水素化反応とシアノ化反応の開拓
Takeshi Ohkuma - Jan. 2022, American Chemical Society, Citations for Chemical Breakthrough Awards
Asymmetric Hydrogenation of β-Keto Carboxylic Esters. A Practical Curly Chemical Access to β-Hydroxy Esters in High Enantiomeric Purity, J. Am. Chem. Soc. 1987, 109, 5856-5858.
R. Noyori;T. Ohkuma;M. Kitamura (Nagoya University);H. Takaya (Institute for Molecular Science);N. Sayo;H. Kumabayashi;S. Akutagawa (Takasago International Corporation). - Mar. 2018, Chemical Society of Japan, The 35th Excellent Scholar Award
Development of Asymmetric Reactions Catalyzed by Ruthenium Complexes with Two Kinds of Ligands
OHKUMA Takeshi - Dec. 2014, University of Malaya, Asian Core Program Lectureship Award
OHKUMA Takeshi - Jun. 2007, International Scientist of the Year 2007
- Mar. 2007, 第３回日本学術振興会賞
Japan - 2007, International Scientist of the Year 2007
- 2007, JSPS Prize
- Jun. 2005, 慶應義塾大学同窓会, 研究教育奨励基金による表彰者
大熊 毅 - Feb. 2000, 有機合成化学協会, エヌ・イー ケムキャット研究企画賞
大熊 毅 - Feb. 1998, 有機合成化学奨励賞
大熊 毅
Papers
- Asymmetric Hydrogenation Catalyzed by Ru Complexes
Takeshi Ohkuma
Organometallic News, 2, 55, 60, 19 May 2025, [Peer-reviewed], [Invited], [Lead author, Corresponding author]
Japanese, Scientific journal, 46744024 - We Want to Make Lithium Cation Optically Active
Takeshi Ohkuma
Journal of Synthetic Organic Chemistry Japan, 83, 4, 347, 351, Apr. 2025, [Peer-reviewed], [Invited], [Lead author, Corresponding author]
Japanese, Scientific journal, 46744024 - Exclusive Papers of the Editorial Board Members and Topical Advisory Panel Members of Catalysts in Section “Catalysis in Organic and Polymer Chemistry”
Kotohiro Nomura, Raffaella Mancuso, Zhengguo Cai, Samuel Dagorne, Moris S. Eisen, Luca Gonsalvi, Martin Kotora, Bun Yeoul Lee, Shaofeng Liu, Luísa Margarida Martins, Takeshi Ohkuma, Armando Pombeiro, Fabio Ragaini, Carl Redshaw, Marc Visseaux, Zongquan Wu, Hiroto Yoshida, Masamichi Ogasawara
Catalysts, 14, 7, 407, MDPI AG, 27 Jun. 2024, [Peer-reviewed], [Invited]
English, Scientific journal, Herein, I would like to provide an overview of this Special Issue, published in the Organic and Polymer Chemistry Section of Catalysis, comprising contributions from 18 of the journal’s Editorial Board Members [...] - Asymmetric Cyanation of α-Ketimino Ester Derivatives with Chiral Ru–Li Combined Catalysts
Taiga Yurino, Zhen Wu, Kazuaki Suzuki, Rino Nitta, Yusuke Sakaguchi, Takeshi Ohkuma
Organic Letters, 26, 900, 905, American Chemical Society (ACS), 22 Jan. 2024, [Peer-reviewed], [Last author, Corresponding author]
English, Scientific journal, 13483696 - Asymmetric Hydrogenation of α-Alkyl-Substituted β-Keto Esters and Amides through Dynamic Kinetic Resolution
Taiga Yurino, Ryo Nishihara, Toshihisa Yasuda, Shuangli Yang, Noriyuki Utsumi, Takeaki Katayama, Noriyoshi Arai, Takeshi Ohkuma
Organic Letters, 26, 2872, 2876, 05 Jan. 2024, [Peer-reviewed], [Invited], [Last author, Corresponding author]
English, Scientific journal, 13483696 - Ru(η1-BH4)(daipena)(diphosphine): Ruthenabicyclic borohydride complexes for asymmetric hydrogenation of ketones and asymmetric formal hydroamination of allylic alcohols under base-free conditions
Tomohiro Ishizaka, Yuji Nakayama, Taichiro Touge, Yamato Yuki, Kazuhiko Matsumura, Taiga Yurino, Takeshi Ohkuma
Tetrahedron, 133705, 133705, Elsevier BV, 14 Oct. 2023, [Peer-reviewed], [Invited], [Last author, Corresponding author]
English, Scientific journal, 13483696 - Ag-Catalyzed Cyanomethylation of Amines Using Nitromethane as a C1 Source
Takuya Takashima, Hamdiye Ece, Taiga Yurino, Takeshi Ohkuma
Organic Letters, 25, 25, 6052, 6056, American Chemical Society (ACS), 10 Aug. 2023, [Peer-reviewed], [Last author, Corresponding author]
English, Scientific journal, 13483696 - Development of Catalytic Isocyanation via Precise Reactivity Control of Ambident Reagent
Taiga Yurino, Takeshi Ohkuma
Journal of Synthetic Organic Chemistry, Japan, 81, 3, 235, 243, The Society of Synthetic Organic Chemistry, Japan, 01 Mar. 2023, [Peer-reviewed], [Invited], [Last author, Corresponding author]
Japanese, Scientific journal, 13483696 - Asymmetric Hydrogenation of α-Amino Esters into Optically Active β-Amino Alcohols through Dynamic Kinetic Resolution Catalyzed by Ruthenabicyclic Complexes
Hiroki. Ishikawa, Taiga Yurino, Ryo Komatsu, Ming-Yuan Gao, Noriyoshi Arai, Takeshi Ohkuma
Organic Letters, 25, 2355, 2360, American Chemical Society (ACS), Mar. 2023, [Peer-reviewed], [Last author, Corresponding author]
English, Scientific journal, 13483696 - Potassium Alkoxide as an Efficient Catalyst for Nucleophilic Perfluoroalkylation: Attempt at Anion-Controlled Enantioselective Insertion of a Trifluoromethyl Group
Taiga Yurino, Takeshi Ohkuma, Hiroyuki Yamashita, Yuanrong Shan, Zhen Wu
Synlett, 33, 17, 1739, 1744, Georg Thieme Verlag KG, Oct. 2022, [Peer-reviewed], [Last author, Corresponding author]
English, Scientific journal, Abstract
Potassium alkoxide was found to be a highly active catalyst for the nucleophilic trifluoromethylation of carbonyl compounds. The catalytic system was successfully applied to the reactions of both aldehydes and ketones, affording the corresponding trifluoromethylated products in high yields at low catalyst loadings (0.1–0.01 mol%) in several solvents, such as THF, toluene, and CH2Cl2. In addition, the potassium salt of a Ru(II) complex bearing an (S)-2,2′-bis[bis(3,5-dimethylphenyl)phosphinyl]-1,1′-binaphthalene [ (S)-XylBINAP] ligand and two l-threoninate ligands, prepared in situ, catalyzed the enantioselective trifluoromethylation of aromatic aldehydes, although the ee values were not satisfactory (less than 20%)., 13483696 - Aerobic Allylic Amination Catalyzed by Pd(OAc)2/P(OPh)3 System with Low Catalyst Loading
Taiga Yurino, Sunaho Saito, Mizuki Ichihashi, Takeshi Ohkuma
The Journal of Organic Chemistry, 87, 2864, 2872, American Chemical Society (ACS), Jan. 2022, [Peer-reviewed], [Last author, Corresponding author]
English, Scientific journal, 13483696 - Stereoselective construction of cycloheptene-fused indoline frameworks through photosensitised formal [5+2] cycloaddition
Noriyoshi Arai, Takeshi Ohkuma
Tetrahedron Letters, 88, 153588, 153588, Elsevier BV, Jan. 2022, [Peer-reviewed], [Last author, Corresponding author]
English, Scientific journal - Palladium-Catalyzed Nucleophilic Isocyanation for the Synthesis of α-Aryl-α-Isocyanoacetoamide Derivatives
Taiga Yurino, Yuji Tange, Takeshi Ohkuma
Bulletin of the Chemical Society of Japan, 94, 9, 2155, 2161, The Chemical Society of Japan, 15 Sep. 2021, [Peer-reviewed], [Corresponding author]
English, Scientific journal - Asymmetric (Transfer) Hydrogenation of Functionalized Ketones
Noriyoshi Arai, Takeshi Ohkuma
Asymmetric Hydrogenation and Transfer Hydrogenation, 55, 85, Wiley, 26 Apr. 2021 - Silyl Cyanopalladate-Catalyzed Friedel–Crafts-Type Cyclization Affording 3-Aryloxindole Derivatives
Hamdiye Ece, Yuji Tange, Taiga Yurino, Takeshi Ohkuma
Synlett, 32, 935, 939, Georg Thieme Verlag KG, 26 Jan. 2021, [Peer-reviewed], [Corresponding author]
English, Scientific journal,Abstract 3-Aryloxindole derivatives were synthesized through a Friedel–Crafts-type cyclization. The reaction was catalyzed by a trimethylsilyl tricyanopalladate complex generated in situ from trimethylsilyl cyanide and Pd(OAc)2. Wide varieties of diethyl phosphates derived from N-arylmandelamides were converted almost quantitatively into oxindoles. When N,N-dibenzylamide was used instead of an anilide substrate, a benzo-fused δ-lactam was obtained. An oxindole product was subjected to substitution reactions to afford 3,3-diaryloxindoles with two different aryl groups., 13483696 - Photosensitized Intramolecular [2+2] Cycloaddition of 1H-Pyrrolo[2,3-b]pyridines Enabled by the Assistance of Lewis Acids
Noriyoshi Arai, Takeshi Ohkuma
The Journal of Organic Chemistry, 85, 23, 15717, 15725, American Chemical Society (ACS), 04 Dec. 2020, [Peer-reviewed], [Corresponding author]
English, Scientific journal, 13483696 - 〔巻頭言〕伝えることの大切さと難しさ
大熊毅
有機合成化学協会誌, 78, 8, 759, 759, Aug. 2020, [Invited], [Corresponding author] - Selective Conversion of Benzylic Phosphates into Diarylmethanes Through Al(OTf)3-Catalyzed Friedel-Crafts-Type Benzylation
Taiga Yurino, Asuka Hachiya, Keisuke Suzuki, Takeshi Ohkuma
European Journal of Organic Chemistry, 2020, 15, 2225, 2232, Wiley, 23 Apr. 2020, [Peer-reviewed], [Corresponding author]
English, Scientific journal, 13483696 - Friedel−Crafts‐Type Allylation of Phenol Derivatives Catalyzed by In Situ‐Generated Silyl Cyanometallates
Taiga Yurino, Hamdiye Ece, Takeshi Ohkuma
Asian Journal of Organic Chemistry, 9, 4, 557, 560, Wiley, Apr. 2020, [Peer-reviewed], [Invited]
English, Scientific journal, 13483696 - Nucleophilic Isocyanation
Taiga Yurino, Takeshi Ohkuma
ACS Omega, 5, 10, 4719, 4724, American Chemical Society (ACS), 17 Mar. 2020, [Peer-reviewed], [Invited], [Corresponding author]
English, Scientific journal, 13483696 - Ag2O-catalysed nucleophilic isocyanation: selective formation of less-stable benzylic isonitriles
Taiga Yurino, Yuji Tange, Ryutaro Tani, Takeshi Ohkuma
Organic Chemistry Frontiers, 7, 11, 1308, 1313, Royal Society of Chemistry (RSC), 2020, [Peer-reviewed], [Corresponding author]
English, Scientific journal,Both primary and secondary benzylic isonitriles were exclusively produced by the Ag2O-catalysed reaction of benzylic phosphates and trimethylsilyl cyanide without formation of the thermodynamically favoured regioisomers, benzylic nitriles.
, 13483696 - Stereoselective Preparation of Methylenecyclobutane-fused Angular Tetracyclic Spiroindolines via Photosensitized Intramolecular [2+2] Cycloaddition with Allene
Noriyoshi Arai, Takeshi Ohkuma
Tetrahedron Letters, 60, 46, 151252, 151255, Elsevier BV, Nov. 2019, [Peer-reviewed]
English, Scientific journal - Isomerization–Asymmetric Hydrogenation Sequence Converting Racemic β-Ylidenecycloalkanols into Stereocontrolled β-Substituted Cycloalkanols Using a Ru Catalytic System with Dual Roles
Noriyoshi Arai, Yuki Okabe, Takeshi Ohkuma
Advanced Synthesis & Catalysis, 361, 24, 5540, 5547, Nov. 2019, [Peer-reviewed]
English, Scientific journal - Asymmetric Hydrogenation of Mines Catalyzed by Ruthenium Complexes
Takeshi Ohkuma
Catalyst, 61, 5, 291, 297, Oct. 2019, [Peer-reviewed], [Invited]
Japanese, Scientific journal - Pd-Catalyzed Allylic Isocycnation: Nucleophilic N-Terminus Substitution of Ambident Cyanide
Taiga Yurino, Ryutaro Tani, Takeshi Ohkuma
ACS Catalysis, 9, 4434, 4440, Apr. 2019, [Peer-reviewed]
English, Scientific journal - Development of Highly Active Hydrogenation Catalysts
Takeshi Ohkuma
Chemistry & Chemical Industry, 72, 3, 259, 261, Mar. 2019, [Peer-reviewed], [Invited]
Japanese, Scientific journal - Development of Asymmetric Reactions Catalyzed by Ruthenium Complexes with Two Kinds of Ligands
T. Ohkuma, N. Kurono, N. Arai
Bulletin of the Chemical Society of Japan, 92, 3, 475, 504, Dec. 2018, [Peer-reviewed], [Invited]
English, Scientific journal - Asymmetric Hydrogenation of Polysubstituted Aromatic Ketones Catalyzed by the DIPSkewphos/PICA Derivative–Ruthenium(II) Complexes
N. Utsumi, N. Arai, K. Kawaguchi, T. Katayama, T. Yasuda, K. Murata, T. Ohkuma
ChmCatChem, 10, 3955, 3959, Jul. 2018, [Peer-reviewed]
English, Scientific journal - Enantioselective Cyanosilylation of Alkynyl Ketones Catalyzed by Combined Systems Consisting of Chiral Ruthenium(II) Complex and Lithium Phenoxide
Takeshi Ohkuma, Nobuhito Kurono, Yusuke Sakaguchi, Kohei Yamauchi, Taiga Yurino
Advanced Synthesis and Catalysis, 360, 7, 1517, 1522, Wiley-VCH Verlag, 03 Apr. 2018, [Peer-reviewed]
English, Scientific journal - Construction of Unique Heterocyclic Frameworks by Photochemical Reaction of 5- and 6-Membered Heteroaromatics
N. Arai, T. Ohkuma
Heterocycles, 96, 6, 997, 1035, Mar. 2018, [Peer-reviewed], [Invited]
English, Scientific journal - Chemoselectivity Control in the Asymmetric Hydrogenation of γ- and δ-Keto Esters into Hydroxy Esters or Diols
Noriyoshi Arai, Takanori Namba, Kei Kawaguchi, Yuki Matsumoto, Takeshi Ohkuma
Angewandte Chemie - International Edition, 57, 5, 1386, 1389, Wiley-VCH Verlag, 26 Jan. 2018, [Peer-reviewed]
English, Scientific journal - Chiraltechnology
OHKUMA Takeshi
Chemical Engineering Japan, 81, 12, 666, 669, Dec. 2017, [Peer-reviewed], [Invited]
Japanese, Scientific journal - Synthetic Organic Chemistry (2)
N. Arai, T. Ohkuma
Chemistry Today, 12, 18, 23, 東京化学同人, Dec. 2017, [Peer-reviewed], [Invited]
Japanese, Scientific journal - Synthetic Organic Chemistry (1)
N. Arai, T. Ohkuma
Chemistry Today, 11, 17, 21, 東京化学同人, Nov. 2017, [Peer-reviewed], [Invited]
Japanese, Scientific journal - Photochemically Promoted Aza-Diels-Alder-Type Reaction: High Catalytic Activity of the Cr(III)/Bipyridine Complex Enhanced by Visible Light Irradiation
Noriyoshi Arai, Takeshi Ohkuma
Journal of Organic Chemistry, 82, 14, 7628, 7636, American Chemical Society, 21 Jul. 2017, [Peer-reviewed]
English, Scientific journal - Double Asymmetric Hydrogenation of Linear beta,beta-Disubstituted alpha,beta-Unsaturated Ketones into gamma-Substituted Secondary Alcohols using a Dual Catalytic System
Noriyoshi Arai, Hironori Satoh, Ryo Komatsu, Takeshi Ohkuma
CHEMISTRY-A EUROPEAN JOURNAL, 23, 37, 8806, 8809, Jul. 2017, [Peer-reviewed]
English, Scientific journal - Special Issue Dedicated to Professor Ryoji Noyori on the 15th Anniversary of His Nobel Prize in Chemistry: Introductory Remarks
Takeshi Ohkuma
CHEMICAL RECORD, 16, 6, 2428, 2429, Dec. 2016, [Peer-reviewed], [Invited]
English, Scientific journal - Advancement in Catalytic Asymmetric Hydrogenation of Ketones and Imines, and Development of Asymmetric Isomerization of Allylic Alcohols
Takeshi Ohkuma, Noriyoshi Arai
CHEMICAL RECORD, 16, 6, 2801, 2819, Dec. 2016, [Peer-reviewed], [Invited]
English, Scientific journal - Efficient chemoselective hydrogenation of organic azides catalyzed by palladium nanoparticles with alkyne-derived homogeneous supports
Noriyoshi Arai, Nozomi Onodera, Takeshi Ohkuma
TETRAHEDRON LETTERS, 57, 37, 4183, 4186, Sep. 2016, [Peer-reviewed]
English, Scientific journal - Development of Methods for Construction of Heterocyclic Frameworks by Photochemical Activation of Molecules
Noriyoshi Arai, Takeshi Ohkuma
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 74, 4, 360, 371, Apr. 2016, [Peer-reviewed], [Invited]
Japanese, Scientific journal - Catalytic Asymmetric Cyanation Reactions
Nobuhito Kurono, Takeshi Ohkuma
ACS CATALYSIS, 6, 2, 989, 1023, Feb. 2016, [Peer-reviewed], [Invited]
English, Scientific journal - Hydrogenation of nitroarenes with palladium nanoparticles stabilized by alkyne derivatives in homogeneous phase
Noriyoshi Arai, Nozomi Onodera, Atsushi Dekita, Junichi Hori, Takeshi Ohkuma
TETRAHEDRON LETTERS, 56, 25, 3913, 3915, Jun. 2015, [Peer-reviewed]
English, Scientific journal - Asymmetric Hydrogenation of Ketones and Imines Catalyzed by Ru(II) Complexes
OHKUMA Takeshi
Pharmacia, 51, 4, 295, 299, Apr. 2015, [Peer-reviewed]
Japanese, Scientific journal - Stereoselective Preparation of Spiro[4.4] Cyclic Compounds by the Photochemical Activation of Oxazoles
Noriyoshi Arai, Moe Mizota, Takeshi Ohkuma
ORGANIC LETTERS, 17, 1, 86, 89, Jan. 2015, [Peer-reviewed]
English, Scientific journal - NOVEL INTRAMOLECULAR CYCLIZATION-SKELETAL REORGANIZATION OF 2-ARYLTHIAZOLES UNDER PHOTOIRRADIATION
Noriyoshi Arai, Moe Mizota, Takeshi Ohkuma
HETEROCYCLES, 90, 1, 607, 616, Jan. 2015, [Peer-reviewed], [Invited]
English, Scientific journal - Asymmetric Conjugate Hydrocyanation of alpha,beta-Unsaturated N-Acylpyrroles with the Ru(phgly)(2)(binap)-CH3OLi Catalyst System
Yusuke Sakaguchi, Nobuhito Kurono, Kohei Yamauchi, Takeshi Ohkuma
ORGANIC LETTERS, 16, 3, 808, 811, Feb. 2014, [Peer-reviewed]
English, Scientific journal - Enantioselective Isomerization of Primary Allylic Alcohols into Chiral Aldehydes with the tol-binap/dbapen/Ruthenium(II) Catalyst
Noriyoshi Arai, Keisuke Sato, Keita Azuma, Takeshi Ohkuma
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52, 29, 7500, 7504, Jul. 2013, [Peer-reviewed]
English, Scientific journal - Asymmetric Hydrogenation of Alkynyl Ketones with the eta(6)-Arene/TsDPEN-Ruthenium(II) Catalyst
Noriyoshi Arai, Hironori Satoh, Noriyuki Utsumi, Kunihiko Murata, Kunihiko Tsutsumi, Takeshi Ohkuma
ORGANIC LETTERS, 15, 12, 3030, 3033, Jun. 2013, [Peer-reviewed]
English, Scientific journal - Preparation of Diastereomerically Pure and Mixed (S)-PhGly/BIPHEP/Ru(II) Complexes and Their Catalytic Behavior with Li2CO3 in Asymmetric Cyanosilylation of Benzaldehyde
Nobuhito Kurono, Taiki Katayama, Takeshi Ohkuma
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 86, 5, 577, 582, May 2013, [Peer-reviewed]
English, Scientific journal - Synthesis of 8-Oxoberbines and Related Benzolactams by Pd(OAc)2-Catalyzed Direct Aromatic Carbonylation
Mamoru Miyazawa, Takashi Tokuhashi, Akiyoshi Horibata, Takatoshi Nakamura, Yu Onozaki, Nobuhito Kurono, Hisanori Senboku, Masao Tokuda, Takeshi Ohkuma, Kazuhiko Orito
JOURNAL OF HETEROCYCLIC CHEMISTRY, 50, E48, E54, Feb. 2013, [Peer-reviewed]
English, Scientific journal - Asymmetric hydrogenation of quinoxalines, benzoxazines, and a benzothiazine catalyzed by chiral ruthenabicyclic complexes
Noriyoshi Arai, Yu Saruwatari, Kotaro Isobe, Takeshi Ohkuma
Advanced Synthesis and Catalysis, 355, 14-15, 2769, 2774, Wiley-VCH Verlag, 2013, [Peer-reviewed]
English, Scientific journal - 5.11 Reduction - Hydrogenation: C=O; Chemoselective
T. Ohkuma, N. Arai
Comprehensive Chirality, 5, 270, 300, Elsevier Ltd, Sep. 2012, [Peer-reviewed]
English, In book - Asymmetric Cyanation with the Chiral Ru-Li Combined Catalysts
Takeshi Ohkuma, Nobuhito Kurono
SYNLETT, 23, 13, 1865, 1881, Aug. 2012, [Peer-reviewed]
English, Scientific journal - Asymmetric Hydrogenation of N-Arylimines Catalyzed by the Xyl-Skewphos/DPEN-Ruthenium(II) Complex
Noriyoshi Arai, Noriyuki Utsumi, Yuki Matsumoto, Kunihiko Murata, Kunihiko Tsutsumi, Takeshi Ohkuma
ADVANCED SYNTHESIS & CATALYSIS, 354, 11-12, 2089, 2095, Aug. 2012, [Peer-reviewed]
English, Scientific journal - Synthesis of Benzo[c]phenanthridine Alkaloids by Pd(OAc)2-Induced Direct Aromatic Carbonylation
Eri Kumazawa, Takashi Tokuhashi, Akiyoshi Horibata, Nobuhito Kurono, Hisanori Senboku, Masao Tokuda, Takashi Ohkuma, Kazuhiko Orito
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 24, 4622, 4633, Aug. 2012, [Peer-reviewed]
English, Scientific journal - ルテナビシクロ錯体触媒を用いたキノキサリン類の不斉水素化反応
新井則義, 猿渡佑, 磯部孝太郎, 大熊毅
万有生命科学振興国際交流財団札幌シンポジウム, 24th, 45, 07 Jul. 2012
Japanese - Enantioselective Cyanosilylation of Ketones with Amino Acid/BINAP/Ruthenium(II)-Lithium Phenoxide Catalyst Systems
Masato Uemura, Nobuhito Kurono, Yusuke Sakai, Takeshi Ohkuma
ADVANCED SYNTHESIS & CATALYSIS, 354, 10, 2023, 2030, Jul. 2012, [Peer-reviewed]
English, Scientific journal - Synthesis of a 3-Arylisoquinoline Alkajoid, Decumbenine B.
Kumazawa E, Tokuhashi T, Horibata A, Kurono N, Senboku H, Tokuda M, Ohkuma T, Orito K
European Journal of Organic Chemistry, 4622, 4633, Jul. 2012, [Peer-reviewed]
English, Scientific journal - Design of molecular catalysts for achievement of high turnover number in homogeneous hydrogenation.
Arai N, Ohkuma T
Chemical record (New York, N.Y.), 12, 2, 284, 289, 2, Apr. 2012, [Peer-reviewed] - 新規なルテナビシクロ錯体触媒(RUCY)によるケトン類の高速かつ高選択的不斉水素化反応
松村和彦, 新井則義, 堀清人, 齊藤隆夫, 佐用昇, 大熊毅
日本化学会講演予稿集, 92nd, 2, 342, 09 Mar. 2012
Japanese - ルテニウム錯体触媒によるN‐アリールイミン類の不斉水素化反応
内海典之, 新井則義, 松本祐樹, 村田邦彦, 堤邦彦, 大熊毅
日本化学会講演予稿集, 92nd, 4, 1463, 09 Mar. 2012
Japanese - ルテニウム/リチウム複合錯体触媒を用いるアルジミン類の不斉ヒドロシアノ化反応
植村真人, 黒野暢仁, 大熊毅
日本化学会講演予稿集, 92nd, 4, 1381, 09 Mar. 2012
Japanese - Novel Intramolecular Photocyclization of alpha-Arylthiophene Derivatives
Noriyoshi Arai, Koichiro Tanaka, Takeshi Ohkuma
ORGANIC LETTERS, 14, 6, 1488, 1491, Mar. 2012, [Peer-reviewed]
English, Scientific journal - Enantioselective Hydrocyanation of N-Protected Aldimines
Masato Uemura, Nobuhito Kurono, Takeshi Ohkuma
ORGANIC LETTERS, 14, 3, 882, 885, Feb. 2012, [Peer-reviewed]
English, Scientific journal - Phosphane-Free Pd-0-Catalyzed Cycloamination and Carbonylation with Pd(OAc)(2) and Cu(OAc)(2) in the Presence of K2CO3: Preparation of Benzocyclic Amines and Benzolactams
Rika Harada, Naoto Nishida, Shiho Uchiito, Yu Onozaki, Nobuhito Kurono, Hisanori Senboku, Tokuda Masao, Takeshi Ohkuma, Kazuhiko Orito
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 2, 366, 379, Jan. 2012, [Peer-reviewed]
English, Scientific journal - Kinetic Resolution of Racemic alpha-tert-Alkyl-alpha-hydroxy Esters by Enantiomer-Selective Carbamoylation
Nobuhito Kurono, Kentaro Ohtsuga, Masanori Wakabayashi, Tadahiro Kondo, Hirohito Ooka, Takeshi Ohkuma
JOURNAL OF ORGANIC CHEMISTRY, 76, 24, 10312, 10318, Dec. 2011
English, Scientific journal - Kinetic Resolution of Racemic alpha-tert-Alkyl-alpha-hydroxy Esters by Enantiomer-Selective Carbamoylation
Nobuhito Kurono, Kentaro Ohtsuga, Masanori Wakabayashi, Tadahiro Kondo, Hirohito Ooka, Takeshi Ohkuma
JOURNAL OF ORGANIC CHEMISTRY, 76, 24, 10312, 10318, Dec. 2011, [Peer-reviewed]
English, Scientific journal - Catalyst-Controlled Diastereoselection in the Hydrogenation of Heterocycloalkyl Ketones
Masaya Akashi, Noriyoshi Arai, Tsutomu Inoue, Takeshi Ohkuma
ADVANCED SYNTHESIS & CATALYSIS, 353, 11-12, 1955, 1960, Aug. 2011
English, Scientific journal - ルテニウム錯体/C6H5OLi触媒系を用いるα,β‐不飽和ケトン類の不斉共役シアノ化反応
坂口祐亮, 新居紀之, 黒野暢仁, 大熊毅
万有生命科学振興国際交流財団札幌シンポジウム, 23rd, 54, 02 Jul. 2011
Japanese - Chiral Ruthenabicyclic Complexes: Precatalysts for Rapid, Enantioselective, and Wide-Scope Hydrogenation of Ketones
Kazuhiko Matsumura, Noriyoshi Arai, Kiyoto Hori, Takao Saito, Noboru Sayo, Takeshi Ohkuma
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133, 28, 10696, 10699, Jul. 2011
English, Scientific journal - ルテニウム錯体/C6H5OLi触媒系を用いるα,β‐不飽和ケトン類の不斉共役シアノ化反応
坂口祐亮, 新居紀之, 黒野暢仁, 大熊毅
日本化学会北海道支部夏季研究発表会講演要旨集, 2011, 15, 01 Jul. 2011
Japanese - Chiral Ruthenabicyclic Complexes: Precatalysts for Rapid, Enantioselective, and Wide-Scope Hydrogenation of Ketones
Kazuhiko Matsumura, Noriyoshi Arai, Kiyoto Hori, Takao Saito, Noboru Sayo, Takeshi Ohkuma
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133, 28, 10696, 10699, Jul. 2011, [Peer-reviewed]
English, Scientific journal - BINAP
Takeshi Ohkuma, Nobuhito Kurono
Privileged Chiral Ligands and Catalysts, 1, 53, Wiley-VCH, 07 Apr. 2011, [Peer-reviewed]
English, In book - BINAP/IPHAN‐Ru(II)錯体触媒によるビシクロケトン類の不斉水素化反応
新井則義, 明石真也, 杉崎聡, 大岡浩仁, 井上勉, 大熊毅
日本化学会講演予稿集, 91st, 4, 1256, 11 Mar. 2011
Japanese - ルテニウム錯体/C6H5OLi触媒系を用いるα,β‐不飽和ケトン類の不斉共役シアノ化反応
坂口祐亮, 新居紀之, 黒野暢仁, 大熊毅
日本化学会講演予稿集, 91st, 4, 1286, 11 Mar. 2011
Japanese - Cu(I)触媒による逆電子要請分子内イミニウムエン反応を用いた4‐アミノ‐3‐メチレンクロマン類の簡便合成
新井則義, 大熊毅
日本化学会講演予稿集, 91st, 4, 1203, 11 Mar. 2011
Japanese - ルテニウム‐リチウム複合錯体を用いるアルデヒド類の不斉ヒドロシアノ化反応
黒野暢仁, 吉川達也, 山崎幹緒, 大熊毅
日本化学会講演予稿集, 91st, 4, 1286, 11 Mar. 2011
Japanese - Enantioselective Hydrocyanation of Aldehydes Catalyzed by [Li{Ru(phgly)(2)(binap)}]X (X = Cl, Br)
Nobuhito Kurono, Tatsuya Yoshikawa, Mikio Yamasaki, Takeshi Ohkuma
ORGANIC LETTERS, 13, 5, 1254, 1257, Mar. 2011
English, Scientific journal - Intramolecular iminium ene reaction with Cu(I) catalysts: facile formation of 4-amino-3-methylenechromans from O-propargyl salicylaldehydes and dialkylamines
Noriyoshi Arai, Takeshi Ohkuma
TETRAHEDRON, 67, 9, 1617, 1622, Mar. 2011
English, Scientific journal - Enantioselective Hydrocyanation of Aldehydes Catalyzed by [Li{Ru(phgly)(2)(binap)}]X (X = Cl, Br)
Nobuhito Kurono, Tatsuya Yoshikawa, Mikio Yamasaki, Takeshi Ohkuma
ORGANIC LETTERS, 13, 5, 1254, 1257, Mar. 2011, [Peer-reviewed]
English, Scientific journal - Asymmetric Hydrocyanation of alpha,beta-Unsaturated Ketones into beta-Cyano Ketones with the [Ru(phgly)(2)(binap)]/C6H5OLi Catalyst System
Nobuhito Kurono, Noriyuki Nii, Yusuke Sakaguchi, Masato Uemura, Takeshi Ohkuma
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 24, 5541, 5544, 2011
English, Scientific journal - Asymmetric Hydrocyanation of alpha,beta-Unsaturated Ketones into beta-Cyano Ketones with the [Ru(phgly)(2)(binap)]/C6H5OLi Catalyst System
Nobuhito Kurono, Noriyuki Nii, Yusuke Sakaguchi, Masato Uemura, Takeshi Ohkuma
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 24, 5541, 5544, 2011, [Peer-reviewed]
English, Scientific journal - Asymmetric Hydrogenation of Bicyclic Ketones Catalyzed by BINAP/IPHAN-Ru(II) Complex
Noriyoshi Arai, Masaya Akashi, Satoshi Sugizaki, Hirohito Ooka, Tsutomu Inoue, Takeshi Ohkuma
ORGANIC LETTERS, 12, 15, 3380, 3383, Aug. 2010
English, Scientific journal - Asymmetric Hydrogenation of Bicyclic Ketones Catalyzed by BINAP/IPHAN-Ru(II) Complex
Noriyoshi Arai, Masaya Akashi, Satoshi Sugizaki, Hirohito Ooka, Tsutomu Inoue, Takeshi Ohkuma
ORGANIC LETTERS, 12, 15, 3380, 3383, Aug. 2010, [Peer-reviewed]
English, Scientific journal - Xylskewphos/PICA‐ルテニウム錯体を触媒に用いる実用的な3‐キヌクリジノンの不斉水素化反応
堤邦彦, 大熊毅, 片山武昭, 内海典之, 村田邦彦, 新井則義, 黒野暢仁
日本化学会講演予稿集, 90th, 4, 1221, 12 Mar. 2010
Japanese - Ru(phgly)2(binap)錯体を用いるα‐ケトエステル類の不斉シアノシリル化反応
黒野暢仁, 植村真人, 大熊毅
日本化学会講演予稿集, 90th, 4, 1221, 12 Mar. 2010
Japanese - パラジウムナノ粒子‐テトラブチルアンモニウムボロヒドリド触媒系によるアルキン類の高活性かつ高選択的な部分水素化反応
堀順一, 村田邦彦, 菅井俊樹, 篠原久典, 野依良治, 新井則義, 黒野暢仁, 大熊毅
日本化学会講演予稿集, 90th, 4, 1350, 12 Mar. 2010
Japanese - MsDPEN‐Cp*イリジウム錯体触媒を用いる芳香族複素環状ケトン類の不斉水素化反応
内海典之, 大熊毅, 堤邦彦, 渡辺正人, 村田邦彦, 新井則義, 黒野暢仁
日本化学会講演予稿集, 90th, 4, 1215, 12 Mar. 2010
Japanese - Asymmetric hydrogenation of ketones: Tactics to achieve high reactivity, enantioselectivity, and wide scope
Takeshi Ohkuma
Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 86, 3, 202, 219, Mar. 2010
English - Asymmetric Cyanosilylation of alpha-Keto Esters Catalyzed by the [Ru(phgly)(2)(binap)]-C6H5OLi System
Nobuhito Kurono, Masato Uemura, Takeshi Ohkuma
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2010, 8, 1455, 1459, Mar. 2010
English, Scientific journal - Photosensitized intramolecular cyclization of furan and non-activated alkene: pathway switching by the substituent on the furan ring
Noriyoshi Arai, Koichiro Tanaka, Takeshi Ohkuma
TETRAHEDRON LETTERS, 51, 9, 1273, 1275, Mar. 2010
English, Scientific journal - Asymmetric hydrogenation of ketones: Tactics to achieve high reactivity, enantioselectivity, and wide scope
Takeshi Ohkuma
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 86, 3, 202, 219, Mar. 2010, [Peer-reviewed]
English - Chiral eta(6)-Arene/N-Tosylethylenediamine-Ruthenium(II) Complexes: Solution Behavior and Catalytic Activity for Asymmetric Hydrogenation
Christian A. Sandoval, Fusheng Bie, Aki Matsuoka, Yoshiki Yamaguchi, Hiroshi Naka, Yuehui Li, Koichi Kato, Noriyuki Utsumi, Kunihiko Tsutsumi, Takeshi Ohkuma, Kunihiko Murata, Ryoji Noyori
CHEMISTRY-AN ASIAN JOURNAL, 5, 4, 806, 816, 2010
English, Scientific journal - ASYMMETRIC HYDROGENATION OF AROMATIC HETEROCYCLIC KETONES CATALYZED BY THE MsDPEN-Cp*Ir(III) COMPLEX
Noriyuki Utsumi, Kunihiko Tsutsumi, Masahiko Watanabe, Kunihiko Murata, Noriyoshi Arai, Nobuhito Kurono, Takeshi Ohkume
HETEROCYCLES, 80, 1, 141, 147, Jan. 2010
English, Scientific journal - Chiral eta(6)-Arene/N-Tosylethylenediamine-Ruthenium(II) Complexes: Solution Behavior and Catalytic Activity for Asymmetric Hydrogenation
Christian A. Sandoval, Fusheng Bie, Aki Matsuoka, Yoshiki Yamaguchi, Hiroshi Naka, Yuehui Li, Koichi Kato, Noriyuki Utsumi, Kunihiko Tsutsumi, Takeshi Ohkuma, Kunihiko Murata, Ryoji Noyori
CHEMISTRY-AN ASIAN JOURNAL, 5, 4, 806, 816, 2010, [Peer-reviewed]
English, Scientific journal - Asymmetric Hydrogenation of Ketones Catalyzed by Ru Complexes
OHKUMA TAKESHI
Catalysts & Catalysis, 51, 8, 577, 582, 触媒学会, 10 Dec. 2009, [Corresponding author]
Japanese, 10239699 - Asymmetric Hydrogenation of Ketones Catalyzed by Ru Complexes.
OKUMA TAKESHI
触媒, 51, 8, 577-582, 582, 触媒学会, 10 Dec. 2009
Japanese - Highly Active and Selective Semihydrogenation of Alkynes with the Palladium Nanoparticles-Tetrabutylammonium Borohydride Catalyst System
Junichi Hori, Kunihiko Murata, Toshiki Sugai, Hisanori Shinohara, Ryoji Noyori, Noriyoshi Arai, Nobuhito Kurono, Takeshi Ohkuma
ADVANCED SYNTHESIS & CATALYSIS, 351, 18, 3143, 3149, Dec. 2009
English, Scientific journal - BINAP/DMAPEN—Ru(II)錯体触媒を用いるカルコン類の不斉水素化反応
新井則義, 東慶太, 新居紀之, 大熊毅
万有生命科学振興国際交流財団札幌シンポジウム, 21st, 45, 04 Jul. 2009
Japanese - 銅触媒によるラセミ体α‐ヒドロキシエステル類の速度論分割の研究
黒野暢仁, 大津賀健太郎, 若林真徳, 近藤忠弘, 大岡浩仁, 大熊毅
日本化学会北海道支部夏季研究発表会講演要旨集, 2009, 8, 26 Jun. 2009
Japanese - フランと単純アルケンとの光増感Diels‐Alder反応の開発研究
新井則義, 田中皓一朗, 大熊毅
日本化学会北海道支部夏季研究発表会講演要旨集, 2009, 20, 26 Jun. 2009
Japanese - ルテニウム錯体を用いるアルデヒド類の不斉シアノシリル化反応
植村真人, 新井健太, 黒野暢仁, 大熊毅
万有生命科学振興国際交流財団福岡シンポジウム, 19th, 40, 23 May 2009
Japanese - Practical Asymmetric Hydrogenation of 3-Quinuclidinone Catalyzed by the XylSkewphos/PICA-Ruthenium(II) Complex
Kunihiko Tsutsumi, Takeaki Katayama, Noriyuki Utsumi, Kunihiko Murata, Noriyoshi Arai, Nobuhito Kurono, Takeshi Ohkuma
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 13, 3, 625, 628, May 2009
English - Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by the TolBINAP/DMAPEN-Ruthenium(II) Complex: A Significant Effect of N-Substituents of Chiral 1,2-Diamine Ligands on Enantioselectivity
Hirohito Ooka, Noriyoshi Arai, Keita Azuma, Nobuhito Kurono, Takeshi Ohkuma
JOURNAL OF ORGANIC CHEMISTRY, 73, 22, 9084, 9093, Nov. 2008
English, Scientific journal - Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by the TolBINAP/DMAPEN-Ruthenium(II) Complex: A Significant Effect of N-Substituents of Chiral 1,2-Diamine Ligands on Enantioselectivity
Hirohito Ooka, Noriyoshi Arai, Keita Azuma, Nobuhito Kurono, Takeshi Ohkuma
JOURNAL OF ORGANIC CHEMISTRY, 73, 22, 9084, 9093, Nov. 2008, [Peer-reviewed]
English, Scientific journal - 銅触媒によるα‐ヒドロキシラクトン類のエナンチオマー選択的カーバメート化反応
若林真徳, 近藤忠弘, 大岡浩仁, 田地川浩人, 黒野暢仁, 大熊毅
日本化学会北海道支部研究発表会講演要旨集, 2008, 34, 19 Jul. 2008
Japanese - ルテニウム錯体を用いるアルデヒド類の不斉シアノシリル化反応
植村真人, 新井健太, 黒野暢仁, 大熊毅
日本化学会北海道支部研究発表会講演要旨集, 2008, 33, 19 Jul. 2008
Japanese - ルテニウム錯体を用いるアルデヒド類の不斉シアノシリル化反応
植村真人, 新井健太, 黒野暢仁, 大熊毅
万有生命科学振興国際交流財団札幌シンポジウム, 20th, 56, 05 Jul. 2008
Japanese - Carbonyl Hydroboration
Noriyoshi Arai, Takeshi Ohkuma
Modern Reduction Methods, 159, 181, John Wiley and Sons, 04 Apr. 2008, [Peer-reviewed]
English, In book - MsDPEN‐Cp*イリジウム錯体触媒を用いるα‐ヒドロキシケトン類の不斉水素化反応
大熊毅, 内海典之, 渡辺正人, 堤邦彦, 新井則義, 村田邦彦
日本化学会講演予稿集, 88th, 2, 1158, 12 Mar. 2008
Japanese - TolBINAP/ジアミン‐ルテニウム(II)錯体を用いるアシルシラン類の触媒的不斉水素化反応
新井則義, 鈴木賢, 杉崎聡, 反町尋子, 大熊毅
日本化学会講演予稿集, 88th, 2, 1108, 12 Mar. 2008
Japanese - TolBINAP/ジアミン‐ルテニウム(II)錯体を用いるカルコン類の触媒的不斉水素化
新井則義, 東慶太, 新居紀之, 大熊毅
日本化学会講演予稿集, 88th, 2, 1107, 12 Mar. 2008
Japanese - 銅触媒によるα‐ヒドロキシラクトン類のエナンチオマー選択的カーバメート化反応
若林真徳, 近藤忠弘, 大岡浩仁, 田地川浩人, 黒野暢仁, 大熊毅
日本化学会講演予稿集, 88th, 2, 1268, 12 Mar. 2008
Japanese - Enantioselective Ketone and β-Keto Ester Hydrogenations (Including Mechanisms)
Takeshi Ohkuma, Ryoji Noyori
The Handbook of Homogeneous Hydrogenation, 1105, 1163, John Wiley and Sons, 31 Jan. 2008, [Peer-reviewed]
English, In book - Highly enantioselective hydrogenation of aryl vinyl ketones to allylic alcohols catalyzed by the tol-binap/dmapen ruthenium(II) complex
Noriyoshi Arai, Keita Azuma, Noriyuki Nii, Takeshi Ohkuma
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47, 39, 7457, 7460, 2008
English, Scientific journal - [Ru(phgly)(2)(binap)]/Li(2)CO(3): A highly active, robust, and enantioselective catalyst for the cyanosilylation of aldehydes
Nobuhito Kurono, Kenta Arai, Masato Uemura, Takeshi Ohkuma
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47, 35, 6643, 6646, 2008
English, Scientific journal - Enantiomer-selective carbamoylation of racemic alpha-hydroxy gamma-lactones with chiral Cu-II catalysts: An example of a highly active Lewis acid catalyzed reaction
Nobuhito Kurono, Tadahiro Kondo, Masanori Wakabayashi, Hirohito Ooka, Tsutomu Inoue, Hiroto Tachikawa, Takeshi Ohkuma
CHEMISTRY-AN ASIAN JOURNAL, 3, 8-9, 1289, 1297, 2008
English, Scientific journal - Asymmetric hydrogenation of aromatic, aliphatic, and alpha,beta-unsaturated acyl silanes catalyzed by tol-binap/pica ruthenium(II) complexes: Practical synthesis of optically active alpha-hydroxysilanes
Noriyoshi Arai, Ken Suzuki, Satoshi Sugizaki, Hiroko Sorimachi, Takeshi Ohkuma
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47, 9, 1770, 1773, 2008
English, Scientific journal - TolBINAP/ジアミン‐ルテニウム(II)錯体を用いるカルコン類の触媒的不斉水素化
新井則義, 東慶太, 新居紀之, 大熊毅
有機合成シンポジウム講演要旨集, 94th, 98-99, 2008
Japanese - 分子集合体型錯体触媒を用いるケトン類およびイミン類の不斉水素化 平成18‐19年度
大熊毅
分子集合体型錯体触媒を用いるケトン類およびイミン類の不斉水素化 平成18−19年度 No.18350046, 241P, 2008
Japanese - Asymmetric hydrogenation of aromatic, aliphatic, and alpha,beta-unsaturated acyl silanes catalyzed by tol-binap/pica ruthenium(II) complexes: Practical synthesis of optically active alpha-hydroxysilanes
Noriyoshi Arai, Ken Suzuki, Satoshi Sugizaki, Hiroko Sorimachi, Takeshi Ohkuma
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47, 9, 1770, 1773, 2008, [Peer-reviewed]
English, Scientific journal - Enantiomer-selective carbamoylation of racemic alpha-hydroxy gamma-lactones with chiral Cu-II catalysts: An example of a highly active Lewis acid catalyzed reaction
Nobuhito Kurono, Tadahiro Kondo, Masanori Wakabayashi, Hirohito Ooka, Tsutomu Inoue, Hiroto Tachikawa, Takeshi Ohkuma
CHEMISTRY-AN ASIAN JOURNAL, 3, 8-9, 1289, 1297, 2008, [Peer-reviewed]
English, Scientific journal - [Ru(phgly)(2)(binap)]/Li(2)CO(3): A highly active, robust, and enantioselective catalyst for the cyanosilylation of aldehydes
Nobuhito Kurono, Kenta Arai, Masato Uemura, Takeshi Ohkuma
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47, 35, 6643, 6646, 2008, [Peer-reviewed]
English, Scientific journal - Highly enantioselective hydrogenation of aryl vinyl ketones to allylic alcohols catalyzed by the tol-binap/dmapen ruthenium(II) complex
Noriyoshi Arai, Keita Azuma, Noriyuki Nii, Takeshi Ohkuma
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47, 39, 7457, 7460, 2008, [Peer-reviewed]
English, Scientific journal - Tailor-made catalysts for asymmetric hydrogenation of ketones
Takeshi Ohkuma
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 65, 11, 1070, 1080, Nov. 2007
English, Scientific journal - On the synthesis of protopine alkaloids
Yasuhiro Wada, Harumi Kaga, Shiho Uchiito, Eri Kumazawa, Miho Tomiki, Yu Onozaki, Nobuhito Kurono, Masao Tokuda, Takeshi Ohkuma, Kazuhiko Orito
JOURNAL OF ORGANIC CHEMISTRY, 72, 19, 7301, 7306, Sep. 2007
English, Scientific journal - On the synthesis of protopine alkaloids
Yasuhiro Wada, Harumi Kaga, Shiho Uchiito, Eri Kumazawa, Miho Tomiki, Yu Onozaki, Nobuhito Kurono, Masao Tokuda, Takeshi Ohkuma, Kazuhiko Orito
JOURNAL OF ORGANIC CHEMISTRY, 72, 19, 7301, 7306, Sep. 2007, [Peer-reviewed]
English, Scientific journal - α位分枝芳香族ケトン類の不斉水素化
新井則義, 大岡浩仁, 大岡浩仁, 東慶太, 薮内俊夫, 井上勉, 大熊毅
万有生命科学振興国際交流財団札幌シンポジウム, 19th, 38, 07 Jul. 2007
Japanese - Asymmetric hydrogenation of alpha-hydroxy ketones catalyzed by MsDPEN-Cp*Ir(III) complex
Takeshi Ohkuma, Noriyuki Utsumi, Masahito Watanabe, Kunihiko Tsutsumi, Noriyoshi Arai, Kunihiko Murata
ORGANIC LETTERS, 9, 13, 2565, 2567, Jun. 2007
English, Scientific journal - Asymmetric hydrogenation of alpha-hydroxy ketones catalyzed by MsDPEN-Cp*Ir(III) complex
Takeshi Ohkuma, Noriyuki Utsumi, Masahito Watanabe, Kunihiko Tsutsumi, Noriyoshi Arai, Kunihiko Murata
ORGANIC LETTERS, 9, 13, 2565, 2567, Jun. 2007, [Peer-reviewed]
English, Scientific journal - 光学活性ルテニウム錯体触媒によるα‐クロロアセトフェノン類の不斉水素化反応
堤邦彦, 大熊毅, 内海典之, 新井則義, 野依良治, 村田邦彦
日本化学会講演予稿集, 87th, 2, 1002, 12 Mar. 2007
Japanese - η6‐アレーン/TsDPEN‐ルテニウム錯体触媒を用いるケトン類の不斉水素化:光学活性4‐クロマノールの合成
内海典之, 大熊毅, 堤邦彦, 村田邦彦, SANDOVAL C. A, 野依良治, 野依良治
日本化学会講演予稿集, 87th, 2, 1002, 12 Mar. 2007
Japanese - General asymmetric hydrogenation of alpha-branched aromatic ketones catalyzed by TolBINAP/DMAPEN-ruthenium(II) complex
Noriyoshi Arai, Hirohito Ooka, Keita Azuma, Toshio Yabuuchi, Nobuhito Kurono, Tsutomu Inoue, Takeshi Ohkuma
ORGANIC LETTERS, 9, 5, 939, 941, Mar. 2007
English, Scientific journal - General asymmetric hydrogenation of alpha-branched aromatic ketones catalyzed by TolBINAP/DMAPEN-ruthenium(II) complex
Noriyoshi Arai, Hirohito Ooka, Keita Azuma, Toshio Yabuuchi, Nobuhito Kurono, Tsutomu Inoue, Takeshi Ohkuma
ORGANIC LETTERS, 9, 5, 939, 941, Mar. 2007, [Peer-reviewed]
English, Scientific journal - Asymmetric hydrogenation of alpha-chloro aromatic ketones catalyzed by eta(6)-arene/TsDPEN-ruthenium(II) complexes
Takeshi Ohkuma, Kunihiko Tsutsumi, Noriyuki Utsumi, Noriyoshi Arai, Ryoji Noyori, Kunihiko Murata
ORGANIC LETTERS, 9, 2, 255, 257, Jan. 2007
English, Scientific journal - Synthesis of a 3-arylisoquinoline alkaloid, decumbenine B
Yasuhiro Wada, Naoto Nishida, Nobuhito Kurono, Takashi Ohkuma, Kazuhiko Orito
European Journal of Organic Chemistry, 2007, 26, 4320, 4327, 2007
English, Scientific journal - Asymmetric hydrogenation of alpha-chloro aromatic ketones catalyzed by eta(6)-arene/TsDPEN-ruthenium(II) complexes
Takeshi Ohkuma, Kunihiko Tsutsumi, Noriyuki Utsumi, Noriyoshi Arai, Ryoji Noyori, Kunihiko Murata
ORGANIC LETTERS, 9, 2, 255, 257, Jan. 2007, [Peer-reviewed]
English, Scientific journal - The hydrogenation/transfer hydrogenation network: Asymmetric hydrogenation of ketones with chiral eta(6)-arene/N-tosylethylenediamine-ruthenium(II) catalysts
Takeshi Ohkuma, Noriyuki Utsumi, Kunihiko Tsutsumi, Kunihiko Murata, Christian Sandoval, Ryoji Noyori
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128, 27, 8724, 8725, Jul. 2006
English, Scientific journal - Mechanism of asymmetric hydrogenation of acetophenone catalyzed by chiral eta(6)-arene-N-tosylethylenediamine-ruthenium(II) complexes
Christian A. Sandoval, Takeshi Ohkuma, Noriyuki Utsumi, Kunihiko Tsutsumi, Kunihiko Murata, Ryoji Noyori
CHEMISTRY-AN ASIAN JOURNAL, 1, 1-2, 102, 110, Jul. 2006
English, Scientific journal - The hydrogenation/transfer hydrogenation network: Asymmetric hydrogenation of ketones with chiral eta(6)-arene/N-tosylethylenediamine-ruthenium(II) catalysts
Takeshi Ohkuma, Noriyuki Utsumi, Kunihiko Tsutsumi, Kunihiko Murata, Christian Sandoval, Ryoji Noyori
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128, 27, 8724, 8725, Jul. 2006, [Peer-reviewed]
English, Scientific journal - Mechanism of asymmetric hydrogenation of acetophenone catalyzed by chiral eta(6)-arene-N-tosylethylenediamine-ruthenium(II) complexes
Christian A. Sandoval, Takeshi Ohkuma, Noriyuki Utsumi, Kunihiko Tsutsumi, Kunihiko Murata, Ryoji Noyori
CHEMISTRY-AN ASIAN JOURNAL, 1, 1-2, 102, 110, Jul. 2006, [Peer-reviewed]
English, Scientific journal - Ligand Design for Catalytic Asymmetric Reduction
Takeshi Ohkuma, Masato Kitamura, Ryoji Noyori
New Frontiers in Asymmetric Catalysis, 1, 32, John Wiley & Sons, Inc., 14 Jun. 2006, [Peer-reviewed]
English, In book - Cyanosilylation of hetero-substituted ketones catalyzed by LiCl
N Kurono, K Suzuki, T Ohkuma
LETTERS IN ORGANIC CHEMISTRY, 3, 4, 275, 277, Apr. 2006
English, Scientific journal - Solution structures and behavior of trans-RuH(eta(1)-BH4) (binap)(1,2-diamine) complexes
CA Sandoval, Y Yamaguchi, T Ohkuma, K Kato, R Noyori
MAGNETIC RESONANCE IN CHEMISTRY, 44, 1, 66, 75, Jan. 2006
English, Scientific journal - Solution structures and behavior of trans-RuH(eta(1)-BH4) (binap)(1,2-diamine) complexes
CA Sandoval, Y Yamaguchi, T Ohkuma, K Kato, R Noyori
MAGNETIC RESONANCE IN CHEMISTRY, 44, 1, 66, 75, Jan. 2006, [Peer-reviewed]
English, Scientific journal - Lithium chloride: An active and simple catalyst for cyanosilylation of aldehydes and ketones
N Kurono, M Yamaguchi, K Suzuki, T Ohkuma
JOURNAL OF ORGANIC CHEMISTRY, 70, 16, 6530, 6532, Aug. 2005
English, Scientific journal - Lithium chloride: An active and simple catalyst for cyanosilylation of aldehydes and ketones
N Kurono, M Yamaguchi, K Suzuki, T Ohkuma
JOURNAL OF ORGANIC CHEMISTRY, 70, 16, 6530, 6532, Aug. 2005, [Peer-reviewed]
English, Scientific journal - Asymmetric hydrogenation of tert-alkyl ketones
T Ohkuma, CA Sandoval, R Srinivasan, Q Lin, Y Wei, K Muniz, R Noyori
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127, 23, 8288, 8289, Jun. 2005
English, Scientific journal - Asymmetric hydrogenation of tert-alkyl ketones
T Ohkuma, CA Sandoval, R Srinivasan, Q Lin, Y Wei, K Muniz, R Noyori
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127, 23, 8288, 8289, Jun. 2005, [Peer-reviewed]
English, Scientific journal - Metal-ligand bifunctional catalysis for asymmetric hydrogenation
R Noyori, CA Sandoval, K Muniz, T Ohkuma
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 363, 1829, 901, 912, Apr. 2005
English, Scientific journal - Metal-ligand bifunctional catalysis for asymmetric hydrogenation
R Noyori, CA Sandoval, K Muniz, T Ohkuma
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 363, 1829, 901, 912, Apr. 2005, [Peer-reviewed]
English, Scientific journal - Preparation of the dibenz[c,g]azecine structure via ring-opening by singlet oxygen
WADA YASUHIRO, TOMIKI MIHO, TOKUDA MASAO, OKUMA TAKESHI, ORITO KAZUHIKO
日本化学会講演予稿集, 85th, 2, 937, 11 Mar. 2005
Japanese - Cyclization reactions for preparation of dibenzindolizine rings
WADA YASUHIRO, NISHIDA NAOTO, TOKUDA MASAO, OKUMA TAKESHI, ORITO KAZUHIKO
日本化学会講演予稿集, 85th, 2, 937, 11 Mar. 2005
Japanese - Direct aromatic carbonylation using Pd(OAc)2. Synthesis of benzo[c]phenanthridine alkaloids
KUMAZAWA ERI, TOKUHASHI TAKASHI, HORIBATA AKIYOSHI, OKUMA TSUYOSHI, TOKUDA MASAO, ORITO KAZUHIKO
複素環化学討論会講演要旨集, 34th, 229-230, 01 Nov. 2004
Japanese - Stereoselective and highly efficient cyclization using aminyl radical
MIKAMI JUN'YA, HASEGAWA HIKARU, KURONO NOBUHITO, OKUMA TAKESHI, ORITO KAZUHIKO, TOKUDA MASAO
複素環化学討論会講演要旨集, 34th, 231-232, 01 Nov. 2004
Japanese - BINAP/1 4-diamine-ruthenium(II) complexes for efficient asymmetric hydrogenation of 1-tetralones and analogues
T Ohkuma, T Hattori, H Ooka, T Inoue, R Noyori
ORGANIC LETTERS, 6, 16, 2681, 2683, Aug. 2004
English, Scientific journal - BINAP/1 4-diamine-ruthenium(II) complexes for efficient asymmetric hydrogenation of 1-tetralones and analogues
T Ohkuma, T Hattori, H Ooka, T Inoue, R Noyori
ORGANIC LETTERS, 6, 16, 2681, 2683, Aug. 2004, [Peer-reviewed]
English, Scientific journal - Asymmetric hydrogenation of 2-arylated cycloalkanones through dynamic kinetic resolution
T Ohkuma, J Li, R Noyori
SYNLETT, 8, 1383, 1386, Jul. 2004
English, Scientific journal - Toward efficient asymmetric hydrogenation: Architectural and functional engineering of chiral molecular catalysts
R Noyori, M Kitamura, T Ohkuma
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 15, 5356, 5362, Apr. 2004
English, Scientific journal - Toward efficient asymmetric hydrogenation: Architectural and functional engineering of chiral molecular catalysts
R Noyori, M Kitamura, T Ohkuma
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 15, 5356, 5362, Apr. 2004, [Peer-reviewed]
English, Scientific journal - Key chemicals that regulate unexplained biological phenomena. Synthesis of optically-active alcohols with physiological function.
Takeshi Ohkuma
未解明生物現象を司る鍵化学物質 平成11−14年度 No.11175101, 260-263, 2004
Japanese - CFTAエステルのNMR測定によるキラルアルコール類の絶対配置決定法
藤沢英仁, 藤原朋也, 竹内義雄, 大熊毅, 野依良治
フッ素化学討論会講演要旨集, 27th, 24-25, 20 Nov. 2003
Japanese - Mechanism of asymmetric hydrogenation of ketones catalyzed by BINAP/1,2-diamine-ruthenium(II) complexes
CA Sandoval, T Ohkuma, K Muniz, R Noyori
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125, 44, 13490, 13503, Nov. 2003
English - Mechanism of asymmetric hydrogenation of ketones catalyzed by BINAP/1,2-diamine-ruthenium(II) complexes
CA Sandoval, T Ohkuma, K Muniz, R Noyori
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125, 44, 13490, 13503, Nov. 2003, [Peer-reviewed]
English - trans-RuH(eta(1)-BH4)(binap)(1,2-diamine): a catalyst for asymmetric hydrogenation of simple ketones under base-free conditions
T Ohkuma, M Koizumi, K Muniz, G Hilt, C Kabuto, R Noyori
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 124, 23, 6508, 6509, Jun. 2002, [Peer-reviewed]
English, Scientific journal - Noyori Laboratory:A Portrait of Saturday
Ohkuma Takeshi
tits, 7, 1, 80, 81, Japan Science Support Foundation, 2002
Japanese - 単純ケトン類の水素化触媒の開拓 : ユニークな触媒はユニークな発想から生まれる
大熊 毅
有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN, 59, 5, 446, 447, 社団法人 有機合成化学協会, 01 May 2001
Japanese - 単純ケトン類の水素化触媒の開拓 ユニークな触媒はユニークな発想から生まれる
大熊毅
有機合成化学協会誌, 59, 5, 446, 447, The Society of Synthetic Organic Chemistry, Japan, 01 May 2001
Japanese - Asymmetric hydrogenation of ketones with polymer-bound BINAP/diamine ruthenium catalysts
T Ohkuma, H Takeno, Y Honda, R Noyori
ADVANCED SYNTHESIS & CATALYSIS, 343, 4, 369, 375, May 2001, [Peer-reviewed]
English, Scientific journal - General Asymmetric Hydrogenation of Hetero-aromatic Ketones.
OKUMA TAKESHI, KOIZUMI MASATOSHI, YOSHIDA MAKOTO, NOYORI RYOJI
日本化学会講演予稿集, 79th, 2, 1201, 15 Mar. 2001
Japanese - Asymmetric Hydrogenation of Amino and Alkoxy Ketones Using Chiral RuCl2(diphosphine)(1,2-diamine) Complexes.
OKUMA TAKESHI, ISHII DAI, TAKENO HIROSHI, NOYORI RYOJI
日本化学会講演予稿集, 79th, 2, 1201, 15 Mar. 2001
Japanese - Asymmetric Hydrogenation of .ALPHA.-Ethylstyrenes Catalyzed by Chiral Ruthenium Complexes.
FORMAN G S, OKUMA TAKESHI, HEMS W P, NOYORI RYOJI
日本化学会講演予稿集, 79th, 2, 1201, 15 Mar. 2001
Japanese - Asymmetric hydrogenation via architectural and functional molecular engineering
R Noyori, M Koizumi, D Ishii, T Ohkuma
PURE AND APPLIED CHEMISTRY, 73, 2, 227, 232, Feb. 2001, [Peer-reviewed]
English, Scientific journal - Asymmetric catalysis by architectural and functional molecular engineering: Practical chemo- and stereoselective hydrogenation of ketones
R Noyori, T Ohkuma
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 40, 1, 40, 73, 2001, [Peer-reviewed]
English - Asymmetric hydrogenation of alpha-ethylstyrenes catalyzed by chiral ruthenium complexes
GS Forman, T Ohkuma, WP Hems, R Noyori
TETRAHEDRON LETTERS, 41, 49, 9471, 9475, Dec. 2000, [Peer-reviewed]
English, Scientific journal - Asymmetric hydrogenation of amino ketones using chiral RuCl2(diphophine)(1,2-diamine) complexes
T Ohkuma, D Ishii, H Takeno, R Noyori
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 122, 27, 6510, 6511, Jul. 2000, [Peer-reviewed]
English, Scientific journal - General asymmetric hydrogenation of hetero-aromatic ketones
T Ohkuma, M Koizumi, M Yoshida, R Noyori
ORGANIC LETTERS, 2, 12, 1749, 1751, Jun. 2000, [Peer-reviewed]
English, Scientific journal - Enantioselective Hydrogenation of Benzophenones with trans-RuCl2(xylbinap)(daipen) as a Precatalyst.
OKUMA TAKESHI, KOIZUMI MASATOSHI, IKEHIRA HIDEYUKI, YOKOZAWA TOORU, NOYORI RYOJI
日本化学会講演予稿集, 78th, 2, 1043, 15 Mar. 2000
Japanese - Selective hydrogenation of benzophenones to benzhydrols. Asymmetric synthesis of unsymmetrical diarylmethanols
T Ohkuma, M Koizumi, H Ikehira, T Yokozawa, R Noyori
ORGANIC LETTERS, 2, 5, 659, 662, Mar. 2000, [Peer-reviewed]
English, Scientific journal - Asymmetric activation/deactivation of racemic Ru catalysts for highly enantioselective hydrogenation of ketonic substrates
K Mikami, T Korenaga, T Ohkuma, R Noyori
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 39, 20, 3707, 3710, 2000, [Peer-reviewed]
English, Scientific journal - High-speed and highly stereoselective hydrogenation of simple ketones
T Ohkuma
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 57, 8, 667, 676, Aug. 1999
Japanese - Rapid, productive and stereoselective hydrogenation of ketones
R Noyori, T Ohkuma
PURE AND APPLIED CHEMISTRY, 71, 8, 1493, 1501, Aug. 1999, [Peer-reviewed]
English, Scientific journal - Molecule catalyst of which it is the most efficient.
OKUMA TAKESHI
別冊化学, 1999, 111-115, 01 May 1999
Japanese - Asymmetric Hydrogenation of .ALPHA.,.BETA.-Unsaturated Ketones with trans-RuCl2(xylbinap)(1,2-diamine).
OKUMA TAKESHI, KOIZUMI MASATOSHI, DOUCET H, PHAM T, KOZAWA MASAMI, MURATA KUNIHIKO, KATAYAMA EIJI, YOKOZAWA TOORU, NOYORI RYOJI
日本化学会講演予稿集, 76th, 2, 899, 15 Mar. 1999
Japanese - Highly Efficient Asymmetric Hydrogenation of Aromatic Ketones with trans-RuCl2(xylbinap)(1,2-diamine).
OKUMA TAKESHI, KOIZUMI MASATOSHI, DOUCET H, PHAM T, KOZAWA MASAMI, MURATA KUNIHIKO, KATAYAMA EIJI, YOKOZAWA TOORU, NOYORI RYOJI
日本化学会講演予稿集, 76th, 2, 898, 15 Mar. 1999
Japanese - Stereoselective Hydrogenation of Simple Ketones.
OKUMA TAKESHI
日本化学会講演予稿集, 76th, 2, 969, 15 Mar. 1999
Japanese - Conformationally flexible biphenylphosphane ligands for Ru-catalyzed enantioselective hydrogenation
K Mikami, T Korenaga, M Terada, T Ohkuma, T Pham, R Noyori
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 38, 4, 495, 497, 1999, [Peer-reviewed]
English, Scientific journal - Asymmetric hydrogenation of alkenyl, cyclopropyl, and aryl ketones. RuCl2(xylbinap)(1,2-diamine) as a precatalyst exhibiting a wide scope
T Ohkuma, M Koizumi, H Doucet, T Pham, M Kozawa, K Murata, E Katayama, T Yokozawa, T Ikariya, R Noyori
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 120, 51, 13529, 13530, Dec. 1998, [Peer-reviewed]
English, Scientific journal - Chemistry friendly with environment. Stereoselective hydrogenation reaction of simple ketone.
OKUMA TAKESHI
ファルマシア, 34, 11, 1095-1099, Nov. 1998
Japanese - Synthesis of trans-RuCl2(1,2-diamine)(phosphine)2 and trans-RuCl2(1,2-diamine)(diphosphine).
HENRI D, OKUMA TAKESHI, MURATA KUNIHIKO, KOZAWA MASAMI, YOKOZAWA TOORU, KATAYAMA EIJI, IKARIYA TAKAO, NOYORI RYOJI
日本化学会講演予稿集, 74th, 2, 1071, Mar. 1998
Japanese - Hydrogenation of Benzophenones to Benzhydrols.
OKUMA TAKESHI, IKEHIRA HIDEYUKI, IKARIYA TAKAO, NOYORI RYOJI
日本化学会講演予稿集, 74th, 2, 1072, Mar. 1998
Japanese - Stereoselective Hydrogenation of Ketones with 1,2-Diamine-Phosphine-Ruthenium(II) Complexes.
HENRI D, OKUMA TAKESHI, MURATA KUNIHIKO, KOZAWA MASAMI, YOKOZAWA TOORU, KATAYAMA EIJI, IKARIYA TAKAO, NOYORI RYOJI
日本化学会講演予稿集, 74th, 2, 1072, Mar. 1998
Japanese - Asymmetric Activation of Racemic Ruthenium(II) Complexes for Enantioselective Hydrogenation.
OKUMA TAKESHI, HENRI D, PHAM T, NOYORI RYOJI
日本化学会講演予稿集, 74th, 2, 1071, Mar. 1998
Japanese - Asymmetric activation of racemic ruthenium(II) complexes for enantioselective hydrogenation
T Ohkuma, H Doucet, T Pham, K Mikami, T Korenaga, M Terada, R Noyori
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 120, 5, 1086, 1087, Feb. 1998, [Peer-reviewed]
English, Scientific journal - Asymmetric hydrogenation of cyclic alpha,beta-unsaturated ketones to chiral allylic alcohols
T Ohkuma, H Ikehira, T Ikariya, R Noyori
SYNLETT, 5, 467, +, May 1997, [Peer-reviewed]
English, Scientific journal - Asymmetric Hydrogenation of Cyclic .ALPHA.,.BETA.-Unsaturated Ketones to Chiral Allylic Alcohols.
OKUMA TAKESHI, IKEHIRA HIDEYUKI, IKARIYA TAKAO, NOYORI RYOJI
日本化学会講演予稿集, 72nd, 2, 809, Mar. 1997
Japanese - Practical stereoselective synthesis of trans-3-isocamphylcyclohexanol as a sandalwood odor principle.
EMURA MAKOTO, HARADA MAKOTO, TOYODA TAKAAKI, YAMAZAKI TETSURO, OKUMA TAKESHI, IKARIYA TAKAO, NOYORI RYOJI
日本化学会講演予稿集, 72nd, 2, 970, Mar. 1997
Japanese - Enantioselective hydrogenation of simple ketones
T Ohkuma, R Noyori
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 54, 7, 553, 563, Jul. 1996
Japanese, Scientific journal - Diastereoselective Hydrogenation of Ketones Catalyzed by a RuCl2(phosphine)n-1,2-Diamine-KOH Combined System.
OKUMA TAKESHI, OOKA HIROHITO, IKARIYA TAKAO, NOYORI RYOJI
日本化学会講演予稿集, 70th, 2, 1310, Mar. 1996
Japanese - Preferential Hydrogenation of Aldehydes and Ketones.
OKUMA TAKESHI, OOKA HIROHITO, IKARIYA TAKAO, NOYORI RYOJI
日本化学会講演予稿集, 70th, 2, 1309, Mar. 1996
Japanese - Practical asymmetry hydrogenation reaction of ketones.
OKUMA TAKESHI
日本化学会中国四国支部岡山地区化学講演会講演要旨集, 1995, 1,2,3,4, Nov. 1995
Japanese - A Practical Enantioselective Hydrogenation of Aromatic Ketones.
OKUMA TAKESHI, OOKA HIROHITO, HASHIGUCHI SHOHEI, IKARIYA TAKAO, NOYORI RYOJI
日本化学会講演予稿集, 69th, 2, 1149, Mar. 1995
Japanese - A High Speed Hydrogenation of Ketones Catalyzed by Ruthenium Complex with Mixed Ligands.
OKUMA TAKESHI, OOKA HIROHITO, HASHIGUCHI SHOHEI, IKARIYA TAKAO, NOYORI RYOJI
日本化学会講演予稿集, 69th, 2, 1149, Mar. 1995
Japanese - A Practical Enantioselective Hydrogenation of Aromatic Ketones.
OKUMA TAKESHI
創造科学技術推進事業 1994 創造科学技術研究報告会(東京) 第4部講演要旨集, 85-89, 1994
Japanese - A PRACTICAL METHOD FOR ACTIVATION OF COMMERCIAL LITHIUM HYDRIDE - REDUCTIVE SILYLATION OF CARBONYL-COMPOUNDS WITH LITHIUM HYDRIDE AND CHLOROTRIMETHYLSILANE
T OHKUMA, S HASHIGUCHI, R NOYORI
JOURNAL OF ORGANIC CHEMISTRY, 59, 1, 217, 221, Jan. 1994, [Peer-reviewed]
English, Scientific journal - ENANTIOSELECTIVE SYNTHESIS OF 4-SUBSTITUTED GAMMA-LACTONES
T OHKUMA, M KITAMURA, R NOYORI
TETRAHEDRON LETTERS, 31, 38, 5509, 5512, 1990, [Peer-reviewed]
English, Scientific journal - 74 CATALYTIC ASYMMETRIC HYDROGENATION OF FUNCTIONALIZED KETONES
Kitamura M, Ohkuma T, Nishi T, Takaya H, Noyori R
Symposium on the Chemistry of Natural Products, symposium papers, 0, 30, 572, 579, Symposium on the chemistry of natural products, 26 Sep. 1988
Japanese, Under the influence of the (R)- or (S)-BINAP-based Ru(II) complexes (BINAP =2,2'-bis(diphenylphosphino)-1,1'-binaphthyl), a wide range of functionalized ketones are hydrogenated in a highly enantioselective and predictable manner. The hydrogenation proceeds smoothly in alcoholic media at room temperature with initial hydrogen pressure of 40-100 atm. The substrate to catalyst mole ratio ranges from 230 to 2200. Ru complexes of the type RuX_2(binap) (X = halogen, empirical formula), Ru_2Cl_4(binap)_2N(C_2H_5)_3, or Ru(OCOR)_2(binap) are employable as catalysts, depending on the substrates. Va... - Stereoselective synthesis of 1,3-diols.
OHKUMA TAKESHI, NOYORI RYOJI
化学, 43, 7, 480-481, Jul. 1988
Japanese - PB83 A PRACTICAL ASYMMETRIC SYNTHESIS OF CARNITINE
Kitamura M., Ohkuma T., Takaya H., Noyori R.
International Symposium on the Chemistry of Natural Products, 1988, 329, 329, Symposium on the chemistry of natural products, 29 May 1988
English - A PRACTICAL ASYMMETRIC-SYNTHESIS OF CARNITINE
M KITAMURA, T OHKUMA, H TAKAYA, R NOYORI
TETRAHEDRON LETTERS, 29, 13, 1555, 1556, 1988, [Peer-reviewed]
English, Scientific journal - SYNTHESIS OF STATINE AND ITS ANALOGS BY HOMOGENEOUS ASYMMETRIC HYDROGENATION
T NISHI, M KITAMURA, T OHKUMA, R NOYORI
TETRAHEDRON LETTERS, 29, 48, 6327, 6330, 1988, [Peer-reviewed]
English, Scientific journal - ASYMMETRIC-SYNTHESIS OF CHIRAL SYNTHONS BEARING ALKYNYL GROUP VIA ORGANOALUMINUM-PROMOTED PINACOL-TYPE REARRANGEMENT
K SUZUKI, T OHKUMA, M MIYAZAWA, GI TSUCHIHASHI
TETRAHEDRON LETTERS, 27, 3, 373, 376, 1986, [Peer-reviewed]
English, Scientific journal - ENANTIO-CONTROLLED AND DIASTEREO-CONTROLLED SYNTHESIS OF (+)-ELDANOLIDE AND (-)-ELDANOLIDE BASED ON ASYMMETRIC PINACOL-TYPE REARRANGEMENT
K SUZUKI, T OHKUMA, G TSUCHIHASHI
TETRAHEDRON LETTERS, 26, 7, 861, 864, 1985, [Peer-reviewed]
English, Scientific journal - Asymmetric Hydrogenaton of Polysubstituted Aromatic Ketones Catalyzed by the DIPSkewphos/PICA Derivative–Ruthenium(II) Complexes
N. Utsmi, N. Arai, K. Kawaguchi, T. Katayama, T. Yasuda, K. Murata, T. Ohkuma
ChemCatChem, Publishaed, on Web, [Peer-reviewed]
English, Scientific journal - Synthesis of 8-Oxoberbines and Related Benzolactams by Pd(OAc)2-Catalyzed Direct Aromatic Carbonylation
M. Miyazawa, T. Tokuhashi, A. Horibata, T. Nakamura, Y. Onozaki, N. Kurono, H. Senboku, M. Tokuda, T. Ohkuma, K. Orito
[Peer-reviewed]
Other Activities and Achievements
- ルテナビシクロボロヒドリド錯体を用いた塩基無添加条件下でのケトンの不斉水素化反応およびアリルアルコールの不斉ヒドロアミノ化反応
石坂智洋, 中山裕治, 峠太一郎, 結城大和, 松村和彦, 百合野大雅, 百合野大雅, 大熊毅, 大熊毅, 有機合成シンポジウム講演予稿集, 124th, 2024 - Asymmetric Hydrogenation of α-Amino Esters through Dynamic Kinetic Resolution Catalyzed by Ruthenabicyclic Complexes (RUCY)
石川宏紀, 百合野大雅, 百合野大雅, 小松稜, GAO Ming-Yuan, 新井則義, 峠太一郎, 松村和彦, 大熊毅, 大熊毅, シンポジウム「モレキュラー・キラリティー」講演要旨集, 2023 (CD-ROM), 2023 - Enantioresolution and absolute stereochemistry of o-substituted diphenylmethanols
S Kuwahara, M Watanabe, N Harada, M Koizumi, T Ohkuma, ENANTIOMER, 5, 1, 109, 114, 2000
English - Enantioresolution by the chiral phthalic acid method: absolute configurations of (2-methylphenyl)phenylmethanol and related compounds
M Watanabe, S Kuwahara, N Harada, M Koizumi, T Ohkuma, TETRAHEDRON-ASYMMETRY, 10, 11, 2075, 2078, Jun. 1999
English - trans-[RuCl(2)(phosphane)(2)(1,2-diamine)] and chiral trans-[RuCl(2)(diphosphane)(1,2-diamine]): Shelf-stable precatalysts for the rapid, productive, and stereoselective hydrogenation of ketones
H Doucet, T Ohkuma, K Murata, T Yokozawa, M Kozawa, E Katayama, AF England, T Ikariya, R Noyori, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 37, 12, 1703, 1707, Jul. 1998
English - Stereoselective hydrogenation of simple ketones catalyzed by Ruthenium(II) complexes
T Ohkuma, H Ooka, M Yamakawa, T Ikariya, R Noyori, JOURNAL OF ORGANIC CHEMISTRY, 61, 15, 4872, 4873, Jul. 1996
English, Report scientific journal - On the mechanism of the ruthenium catalyzed hydrogenation of simple aromatic ketones
AF England, T Ohkuma, T Ikariya, R Noyori, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 211, 523, INOR, Mar. 1996
English, Summary international conference - PREFERENTIAL HYDROGENATION OF ALDEHYDES AND KETONES
T OHKUMA, H OOKA, T IKARIYA, R NOYORI, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 117, 41, 10417, 10418, Oct. 1995
English, Introduction scientific journal - アルデヒドおよびケトンの優先的水素化
OHKUMA T, OOKA H, IKARIYA T, NOYORI R, Journal of the American Chemical Society, 117, 41, 10417, 10418, 1995 - CONVENIENT PREPARATION OF BINAP RUTHENIUM(II) COMPLEXES CATALYZING ASYMMETRIC HYDROGENATION OF FUNCTIONALIZED KETONES
M KITAMURA, M TOKUNAGA, T OHKUMA, R NOYORI, TETRAHEDRON LETTERS, 32, 33, 4163, 4166, Aug. 1991
English - DYNAMIC KINETIC RESOLUTION IN BINAP-RUTHENIUM(II) CATALYZED HYDROGENATION OF 2-SUBSTITUTED 3-OXO CARBOXYLIC ESTERS
M KITAMURA, T OHKUMA, M TOKUNAGA, R NOYORI, TETRAHEDRON-ASYMMETRY, 1, 1, 1, 4, 1990
English, Introduction scientific journal - STEREOSELECTIVE HYDROGENATION VIA DYNAMIC KINETIC RESOLUTION
R NOYORI, T IKEDA, T OHKUMA, M WIDHALM, M KITAMURA, H TAKAYA, S AKUTAGAWA, N SAYO, T SAITO, T TAKETOMI, H KUMOBAYASHI, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 111, 25, 9134, 9135, Dec. 1989
English, Introduction scientific journal - HOMOGENEOUS ASYMMETRIC HYDROGENATION OF FUNCTIONALIZED KETONES
M KITAMURA, T OHKUMA, S INOUE, N SAYO, H KUMOBAYASHI, S AKUTAGAWA, T OHTA, H TAKAYA, R NOYORI, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 110, 2, 629, 631, Jan. 1988
English, Introduction scientific journal - ASYMMETRIC HYDROGENATION OF BETA-KETO CARBOXYLIC ESTERS - A PRACTICAL, PURELY CHEMICAL ACCESS TO BETA-HYDROXY ESTERS IN HIGH ENANTIOMERIC PURITY
R NOYORI, T OHKUMA, M KITAMURA, H TAKAYA, N SAYO, H KUMOBAYASHI, S AKUTAGAWA, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 109, 19, 5856, 5858, Sep. 1987
English, Introduction scientific journal - PREPARATION OF ENAMINONES BY 2-CARBON HOMOLOGATION OF AMIDES WITH LITHIUM (TRIPHENYLSILYL)ACETYLIDE
K SUZUKI, T OHKUMA, G TSUCHIHASHI, JOURNAL OF ORGANIC CHEMISTRY, 52, 13, 2929, 2930, Jun. 1987
English, Introduction scientific journal
Books and other publications
- Comprehensive Chirality, 2nd edition, Vol. 7
Takeshi Ohkuma, Introduction
Elsevier • Academic Press, May 2024, 9780323906449, 1, English, Scholarly book, 46744024, [Peer-reviewed], [Contributor] - Comprehensive Chirality, 2nd edition, Vol. 7
Taiga Yurino, Takeshi Ohkuma, Reduction: Asymmetric Hydorgenation and Transfer Hydrogenation of C=O Bonds.
Elsevier: Academic Press, May 2024, 9780323906449, 43, English, Scholarly book, [Peer-reviewed], [Contributor] - ドラマチック有機合成化学 : 感動の瞬間100
有機合成化学協会, ケトンの高活性不斉水素化触媒を求めて—遷移状態モデルに基づいた試行錯誤—
化学同人, Jul. 2023, 9784759823363, xiv, 206p, Japanese, [Contributor] - 有機合成のための新触媒反応101
百合野 大雅, 大熊 毅(有機合成化学協会, 檜山, 為次郎, 野崎, 京子, 中尾, 佳亮, 中野, 幸司 編集), カルボニル基のシアノ化; アルケン，アルキンのシアノ官能基化; 不斉Strecker反応
東京化学同人, Nov. 2021, 9784807920051, x, 212p, Japanese - Asymmetric Hydrogenation and Transfer Hydrogenation
Noriyoshi Arai, Takeshi Ohkuma, Asymmetric (Transfer) Hydrogenation of Functionalized Ketones
Wiley-VCH, Apr. 2021, 13483696, [Contributor] - 化学便覧 基礎編 改定６版
新井則義, 大熊 毅, 12.10.3 水素化・水素移動反応 (https://www.chem-reference.com/viewkiso.php?ID=H120028)
丸善, 2020, 13483696, [Joint work] - Atropisomerism and Axial Chirality
Taiga Kurino, Takeshi Ohkuma, Axially Chiral P,P-Ligands for Asymmetric Metal-Catalyzed Reactions
World Scientific, 2019, [Joint work] - Handbook of Organic Synthesis Experiment
N. Arai, T. Ohkuma, Reduction with Gaseous Hydrogen
Maruzen, 2015, [Contributor] - Comprehensive Chirality, Vol. 5
Ohkuma T, Arai N, Reduction–Hydrogenation: C=O; Chemoselective.
Elsevier, 2012, [Contributor] - Privileged Chiral Ligands and Catalysts
Ohkuma T, Kurono N, BINAP
Wiley-VCH, 2011, [Contributor] - Science of Synthesis: Stereoselective Synthesis 2
Arai N, Ohkuma T, Reduction of Carbonyl Compound: Hydrogenation.
Thieme, 2010, [Contributor] - Modern Reduction Methods
Arai N, Ohkuma T, Carbonyl Hydroboration.
Wiley-VCH, 2008, [Contributor] - New Frontiers in Asymmetric Catalysis
Ohkuma T, Kitamura M, Noyori R, Ligand Design for Catalytic Asymmetric Reduction.
John Wiley & Sons, Inc., 2007, [Contributor] - The Handbook of Homogeneous Hydrogenation
Ohkuma T, Noyori R, Enantioselective Ketone and β-Keto Ester Hydrogenation (Including Mechanisms).
Wiley-VCH Verlag GmbH & Co. KGaA, 2007, [Contributor] - 実力養成化学スクール キラル化学
丸善, 2005 - Chirality on Organic Chemistry
Maruzen, 2005 - 化学便覧 基礎編II 第５版
丸善, 2004 - 実験化学講座 第５版 第１９巻 有機化合物の合成VII
丸善, 2004 - Comprehensive Asymmetric Catalysis-Supplement 2
Springer, 2004 - Transition Metals for Organic Synthesis, 2nd Ed
Wiley-VCH, 2004 - 有機合成のための触媒反応103
東京化学同人, 2004 - The Fifth Series of Chemistry Handbook
Marzen, 2004 - The Fifth Series of Experimental Chemistry
Marzen, 2004 - Catalytic Organic Reactions
Tokyo Kagaku Dozin, 2004 - Comprehensive Asymmetric Catalysis-Supplement 1
Springer, 2003 - Handbook of Reagints for Organic Synthesis: Chiral Reagents for Asymmetric Synthesis
John Wiley & Sons, Inc., 2003
Lectures, oral presentations, etc.
- Development of Asymmetric Hydrogenation and Cyanation Catalyzed by Ruthenium Complexes
Takeshi Ohkuma
有機合成化学協会賞受賞講演, 18 Feb. 2025, Japanese, Invited oral presentation
46744024, [Invited] - Development of Asymmetric Hydrogenation Catalyzed by Ruthenium Complexes with Two Kinds of Ligands
Takeshi Ohkuma
近畿化学協会 有機金属部会 2024年度 第３回例会, 22 Nov. 2024, Japanese, Invited oral presentation
46744024, [Invited] - Development of Asymmetric Hydrogenation Catalyzed by Ruthenium Complexes with Two Kinds of Ligands
Takeshi Ohkuma
Wender Fest 2024@Tokyo, 08 Jun. 2024, English, Invited oral presentation
08 Jun. 2024 - 08 Jun. 2024, 46744024, [Invited] - Development of Regio- and Stereoselective Reactions Catalyzed by Metal Complexes
Takeshi Ohkuma
日産化学株式会社 物質科学研究所 講演会, 24 Jul. 2023, Japanese, Invited oral presentation
24 Jul. 2023 - 24 Jul. 2023, [Invited] - Asymmetric Hydrogenation of Simple Ketones
Takeshi Ohkuma
Commemorative Symposium on Citation for Chemical Breakthrough, 02 Jul. 2022, Japanese, Invited oral presentation
02 Jul. 2022, [Invited] - Catalytic Nucleophilic Isocyanation with Pd and Ad Catalysts
Takeshi Okuma
Catalysts Asia-Pacific Academic Forum 2021, 08 Jul. 2021, English, Invited oral presentation
08 Jul. 2021 - 08 Jul. 2021, [Invited] - オープニング（オーガナイザー）
大熊毅
第３２回札幌万有シンポジウム, 12 Dec. 2020, Japanese, Others
12 Dec. 2020 - 12 Dec. 2020, [Invited] - Recent Progress on Asymmetric Hydrogenation with Diphosphine/Diamine–Ru(II) Catalysts
Takeshi Ohkuma
2019 Hokkaido University & Peking University Joint Symposium, 21 Jan. 2019, English, Invited oral presentation
[Invited], [International presentation] - Asymmetric Reactions Catalyzed by Chiral Ruthenium Complexes
Takeshi Ohkuma
Yamaguchi University IoL Center Colloquium, 20 Nov. 2018, Japanese, Invited oral presentation
[Invited], [Domestic Conference] - Development of Asymmetric Reactions Catalyzed by Chiral Ruthenium Complexes with Two Kinds of Ligands
Takeshi Ohkuma
The98th the Chemical Society of Japan Annual Meeting, 20 Mar. 2018, English, Invited oral presentation
[Invited], [Domestic Conference] - Asymmetric Hydrogenation and Isomerization Catalyzed byChiral Ruthenium Complexes
OHKUMA Takeshi
The 5th International Symposium on AMBITIOOUS LEASR'S PROGRAM, 21 Nov. 2017, English, Invited oral presentation
[Invited], [International presentation] - Asymmetric Hydrogenation and Isomerization with Chiral Ru(II) Catalysts
OHKUMA Takeshi
5th UK-Japanese Symposium on Asymmetric Catalysis, 15 Mar. 2016, English, Invited oral presentation
[Invited], [International presentation] - Enantioselective Cyanation Catalyzed by Ru Complex/Li Compound Combined Systems
OHKUMA Takeshi
The 6th Japanese-Sino Symposium on Organic Chemistry for Young Scientists, 07 Jul. 2015, English, Invited oral presentation
[Invited], [International presentation] - Asymmetric Hydrogenation and Isomerization Catalyzed by Ruthenium(II) Complexes
OHKUMA Takeshi
8th Singapore International Chemistry Conference 2014, 16 Dec. 2014, English, Invited oral presentation
[Invited], [International presentation] - Enantioselective Hydrogenation and Isomerization with Chiral Ruthenium(II) Catalysts
OHKUMA Takeshi
The 9th International Conference on Cutting-Edge Organic Chemistry in Asia, 02 Dec. 2014, English, Invited oral presentation
[Invited], [International presentation] - Asymmetric Hydrogenatin with Ruthenium Complexes
OHKUMA Takeshi
日産化学学術講演会, 19 Nov. 2014, Japanese, Invited oral presentation
[Invited], [Domestic Conference] - Asymmetric Hydrogenatin with Molecular Catalysts
OHKUMA Takeshi
タワーホール船堀（東京都江戸川区）, 15 Oct. 2014, Japanese, Invited oral presentation
[Invited], [Domestic Conference] - Preface/Opening Remarks
OHKUMA Takeshi
Frontier Chemistry Center The 3rd International Symposium "Challenges at the Frontier of Chemical Sciences", 13 Jun. 2014, English, Invited oral presentation
[Invited], [International presentation] - Preface/Opening Remarks
OHKUMA Takeshi
Frontier Chemistry Center The 2nd International Symposium "Advanced Material Science", 09 Dec. 2013, English, Invited oral presentation
[Invited], [International presentation] - Practical Synthesis of Optically Active Aicohols
OHKUMA Takeshi
Inovation Japan 2013, 29 Aug. 2013, Japanese, Invited oral presentation
[Invited], [Domestic Conference] - Kinetic Resolution of α-Hydroxy Esters Catalyzed by Chiral Cu Complexes
OHKUMA Takeshi
JST Symposium, 11 Mar. 2013, Japanese, Invited oral presentation
[Invited], [Domestic Conference] - Preface/Opening Remarks
OHKUMA Takeshi
Frontier Chemistry Center The 1st International Symposium "Next Generation of Molecular Chemistry", 22 Feb. 2013, English, Invited oral presentation
[Invited], [International presentation] - Asymmetric Hydrogenation for Practical Synthesis of Chiral Molecules
OHKUMA Takeshi
The 4th Symposium on Academic Exchange and Collaborative Research between MRC-ETHZ and FoE-HU (Coorganized by Frontier Chemistry Center of FoE-HU), 21 Feb. 2013, English, Invited oral presentation
[Invited], [International presentation] - Asymmetric Hydrogenation of Ketones and Imines Catalyzed by Ru(II) Complexes
OHKUMA Takeshi
2012 Hokkaido University & Peking University Joint Symposium on Organic and Organometallic Chemistry, 17 Jul. 2012, English, Invited oral presentation
[Invited], [International presentation] - Asymmetric Cyanation Catalyzed by Ru-Li Combined Systems
OHKUMA Takeshi
The 5th GCOE International Symposium/The 1st International Symposium of Graduate School of Chemical Sciences and Engineering, 21 Feb. 2012, English, Invited oral presentation
[Invited], [International presentation] - Asymmetric Cyanation Catalyzed by the Chiral Ru-Li Combined Systems
OHKUMA Takeshi
大阪大学基礎工学研究科学術講演会, 02 Dec. 2011, Japanese, Invited oral presentation
[Invited], [Domestic Conference] - Asymmetric Cyanosilylation of Aldehydes and α-Keto Esters with the Chiral Ru–Li Combined Catalysts
OHKUMA Takeshi
Joint Pre-Symposium on Organometallic Chemistry, 18 Jul. 2010, English, Invited oral presentation
[Invited], [International presentation] - Asymmetric Cyanosilylation of Aldehydes and α-Keto Esters Catalyzed by the Chiral Ru–Li Combined Systems
OHKUMA Takeshi
22nd International Symposium on Chirality 2010, 15 Jul. 2010, English, Invited oral presentation
[Invited], [International presentation] - Asymmetric Hydrogenation of Ketones Catalyzed by Chiral Ru(II) Complexes
OHKUMA Takeshi
BIT's 1st Annual World Congress of Catalytic Asymmetric Synthesis-2010, 20 May 2010, English, Invited oral presentation
[Invited], [International presentation] - Practcal Synthesis of Optically Active Amino Alcohols
OHKUMA Takeshi
ファーマ i ジャパン, 02 Jul. 2009, Japanese, Invited oral presentation
[Invited], [Domestic Conference] - Asymmetric Reduction of Unsaturated Compounds
OHKUMA Takeshi
有機合成化学講習会, 18 Jun. 2009, Japanese, Public discourse
[Invited], [Domestic Conference] - Asymmetric Cyanosilylation of Aldehydes with the Chiral Ru–Li Catalyst System
OHKUMA Takeshi
The 4th Hokkaido University–Nanjing University Joint Symposium, 17 Dec. 2008, English, Invited oral presentation
[Invited], [International presentation] - Asymmetric Cyanosilylation of Aldehydes with Chiral Ruthenium Catalysts
OHKUMA Takeshi
Taiwan-Japan International Symposium on Organic Chemistry and Molecular Science, 18 Apr. 2008, English, Invited oral presentation
[Invited], [International presentation] - Tailor-made触媒を用いるケトン類の不斉水素化
大熊 毅
近畿化学協会有機金属部会平成１９年度第３回例会, 22 Nov. 2007, Japanese, Invited oral presentation
[Invited], [Domestic Conference] - Tailor-made触媒によるケトン類の不斉水素化
大熊 毅
2007年度 大塚有機合成シンポジウム, 04 Oct. 2007, Japanese, Invited oral presentation
[Invited], [Domestic Conference] - Asymmetric Hydrogenation of Ketones Catalyzed by Tailor-made Ruthenium(II) Complexes
OHKUMA Takeshi
2nd International Conference on Cutting-Edge Organic Chemistry in Asia, 05 Sep. 2007, English, Invited oral presentation
[Invited], [International presentation] - Asymmetric Hydrogenation of Ketones Catalyzed by Tailot-made Ru complexes
OHKUMA Takeshi
The 16th Symposium on Optically Active Compounds, 27 Oct. 2006, English, Invited oral presentation
[Invited], [International presentation] - Asymmetric Hydrogenation of tert-Alkyl Ketones and 1-Tetralones
OHKUMA Takeshi
The 2005 International Chemical Congress of Pacific Basin Societies, 16 Dec. 2005, English, Invited oral presentation
[Invited], [International presentation] - Asymmetric Hydrogenation of Ketones -Design of Chiral Catalysts-
OHKUMA Takeshi
The 15th International Symposium on Fine Chemistry and Functional Polymer (FCFPXIV-2005) & IUPAC 1st International Symposium on Novel Materials and Synthesis (NM-1), 18 Oct. 2005, English, Invited oral presentation
[Invited], [International presentation] - ルテニウム錯体触媒を用いるケトン類の不斉水素化
大熊 毅
第４５回オーロラセミナー第２回規則性多孔体研究会合同セミナー, 25 Jul. 2005, Japanese, Invited oral presentation
[Invited], [Domestic Conference] - ケトン類の不斉水素化ー分子世界の左と右ー
大熊 毅
慶應義塾大学理工学部同窓会研究・教育奨励基金による特別講演会, 18 Jun. 2005, Japanese, Invited oral presentation
[Invited], [Domestic Conference] - ケトン類の不斉水素化ー分子触媒を用いるアプローチー
大熊 毅
第１回生体触媒化学若手講演会, 25 Mar. 2005, Japanese, Invited oral presentation
横浜, [Invited], [Domestic Conference] - Asymmetric Hydrogenation of Simple Ketones
OHKUMA Takeshi
第１５回北海道大学触媒化学研究センター研究討論会, 12 Nov. 2004, Japanese, Invited oral presentation
[Invited], [Domestic Conference] - Asymmetric Hydrogenation of Simple Ketones Catalyzed by Ruthenium Complexes
OHKUMA Takeshi
The 14th International Symposium on Fine Chemistry and Functional Polymer (FCFP XIV-2004), 17 Aug. 2004, English, Invited oral presentation
[Invited], [International presentation] - 新規ルテニウムヒドリド錯体触媒を用いるケトン類の不斉水素化
大熊 毅
第３７回有機金属若手の会 夏の学校, 16 Jul. 2004, Japanese, Invited oral presentation
[Invited], [Domestic Conference] - Asymmetric Hydrogenation of Ketones with Chiral Ru Complexes
OHKUMA Takeshi
北海道大学大学院工学研究科 学術講演会, 03 Mar. 2004, Japanese, Invited oral presentation
[Invited], [Domestic Conference] - Asymmetric Hydrogenation of Ketones
OHKUMA Takeshi
日本化学会創立125周年記念 第15回名古屋コンファレンス「産官学連携と化学」, 18 Dec. 2003, Japanese, Invited oral presentation
[Invited], [Domestic Conference] - Development of Efficient Molecular Catalysts
OHKUMA Takeshi
21世紀COE形成プログラム「分子機能の解明と創造」：第１回成果報告会, 18 Jun. 2003, Japanese, Invited oral presentation
[Invited], [Domestic Conference]
Courses
Affiliated academic society
Works
- Published paper was introduced on the Organic Chemistry Portal https://www.organic-chemistry.org/abstracts/lit7/974.shtm
H. Ece, Y. Tange, T. Yurino, T. Ohkuma, 01 Apr. 2022 - Present - Citations for Chemical Breakthrough Awards (2021) (American Chemical Society)
R. Noyori, T. Ohkuma, M. Kitamura, Nagoya University, H. Takaya, Molecular Science, N. Sayo, H. Kumabayashi, S. Akutagawa, Takasago International Corperation, 20 Jan. 2022 - Present - Topic Information
関東化学株式会社, 01 Apr. 2021 - Present - 新聞掲載（複数社）される「アジアで初の米国化学会「歴史的化学論文大賞」を受賞」
R. Noyori, T. Ohkuma, M. Kitamura, Nagoya University, H. Takaya, Molecular Science, N. Sayo, H. Kumabayashi, S. Akutagawa, Takasago International Corperation, 20 Jan. 2022 - 20 Jan. 2022 - 化学工業日報記事掲載「不斉水素化触媒を新開発 医薬品向け受託合成も活況」
21 Jun. 2020 - 21 Jun. 2020, 13483696 - Commercialization of Catalysts for Asymmetric Hydrogenation: s-PICA
Takeshi Ohkuma, Dec. 2019, [Others] - 北海道大学研究シーズ集Vol. 4 (2017) 掲載「均一系パラジウムナノ粒子触媒による水素化反応 —シスアルケンとアミン類の選択的合成—」 ナノテク・材料分野 p100
大熊 毅, 2017, [Others] - 不斉シアノ化触媒市販開始（日本曹達・関東化学）カタログ作成「—不斉シアノ化触媒—Catalyst for Asymmetric Hydrocyanaiton Asymmetric Cyanosilylation」
大熊 毅, 2017, [Others] - The Chemical Recordの”Special Issue Dedicted to Professor Ryoji Noyori on the 15th Anniversary of His Nobel Prize in Chemistry”でGuest Editorを務めた
大熊 毅, Dec. 2016, [Others] - 北海道大学研究シーズ集Vol. 3 (2016) 掲載「アリルアルコール類の不斉異性化反応 —光学活性β-置換アルデヒド類の高純度合成法—」 ナノテク・材料分野 p99
大熊 毅, 2016, [Others] - 北海道大学研究シーズ集Vol. 2 (2015) 掲載「カルボニル化合物、イミン類の不斉シアノ化反応 —ルテニウム・リチウム複合錯体触媒による多様な光学活性シアン化物の合成—」
大熊 毅, Jun. 2015, [Others] - CSJ Journal Selects Vol. 2 掲載“Preparation of Diastereomerically Pure and Mixed (S)-PhGly/BIPHEP/Ru(II) Complexes and Their Catalytic Behavior with Li2O3 in Asymmetric Cyanosilylation of Benzaldehyde” Asymmetric Catalysis 分野 p5
大熊 毅, 2015, [Others] - Symposium Organizer "Frontier Chemistry Center The 3rd International Symposium" "Challenges at the Frontier of Chemical Sciences"
OHKUMA Takeshi, Jun. 2014, [Others] - 北海道大学研究シーズ集2014掲載「ケトン類・イミン類の不斉水素化反応 —ルテニウム錯体触媒による光学活性アルコール類・アミン類の実用的合成法—」
大熊 毅, May 2014, [Others] - 学術雑誌に記事掲載 Editer’s Eye「光学活性アルデヒドの効率的な合成触媒を開発」「ファルマシア」
大熊 毅, Dec. 2013, [Others] - 新聞記事掲載「みんなでサイエンス 同じ分子に異なる性質？ 作り分けの技術を開発」「北海道新聞」
大熊 毅, Dec. 2013, [Others] - Symposium Organizer "Frontier Chemistry Center The 2nd International Symposium" "Advanced Materials Science"
OHKUMA Takeshi, Dec. 2013, [Others] - 新聞記事掲載「受託製造ビジネス拡大 独自の触媒と配位子活用」「化学工業日報」
大熊 毅, Nov. 2013, [Others] - 新聞記事掲載「アルデヒド、１回で合成 北海道大 新触媒で純度９９％超」「日経産業新聞」
大熊 毅, Jul. 2013, [Others] - 発表論文が雑誌内表紙にハイライトされる
大熊 毅, Jun. 2013, [Others] - Symposium Organizer "Frontier Chemistry Center The 1st International Symposium" "Next Generation of Molecular Chemistry"
OHKUMA Takeshi, Feb. 2013, [Others] - Symposium Organizer "2012 Hokkaido University & Peking University Joint Symposium on Organic and Organometallic Chemistry"
OHKUMA Takeshi, Jul. 2012, [Others] - シンポジウムオーガナイザー「北海道大学グローバルCOEシンポジウム 第１７回精密合成化学セミナー ジョイントシンポジウム」「分子変換と機能開発の新基軸」
大熊 毅, Oct. 2011, [Others] - シンポジウムオーガナイザー「第２３回万有札幌シンポジウム」「有機化学の深化と多様化」
大熊 毅, Jul. 2011, [Others] - 新聞記事掲載「超高速の不斉水素化触媒」「化学工業日報」
Jun. 2011, [Others] - シンポジウムオーガナイザー「第１６回精密合成化学セミナー」
大熊 毅, Jan. 2011, [Others] - シンポジウムオーガナイザー「精密合成化学セミナー」「有機合成化学の新基軸」
大熊 毅, Jan. 2009, [Others] - シンポジウムオーガナイザー「北海道大学グローバルCOEシンポジウム」「触媒的不斉合成の最先端」
大熊 毅, Oct. 2008, [Others] - 北海道大学大学院工学研究科公開講座「応用理工学研究の最先端〜豊かな生活を 目指して〜」「分子の世界の右手と左手」
Oct. 2007, [Others] - 日本化学会・ディビジョンレポート執筆
2007 - イノベーション・ジャパン２００７-大学見本市
2007 - 夢・化学−２１「北海道大学化学系への二日間体験入学」
2007 - 新聞記事掲載
2007 - Division reports of Japan Chemical Society
2007 - Inovation Japan 2007
2007 - 「不斉還元」, 日本化学会
2004 - 2006 - 新聞記事掲載
2005 - 「Chirality in the Molecular World」
2004
Research Themes
- Development of Asymmetric Hydrogenation and Cyanation Catalyzed by Unique Ruthenium Complexes
科学研究費助成事業
Apr. 2024 - Mar. 2027
Takeshi Ohkuma
Japan Society for Promotion of Science, 基盤研究(C), Hokkaido University, Principal investigator, 24K08403 - Development of Catalytic Organic Reactions Based on the Dynamic Behaviors of Molecules
Kakenhi (B)
Apr. 2019 - Mar. 2022
Takeshi Ohkuma
Japan Society for the Promotion of Science, Principal investigator, Competitive research funding - 特異な配位子効果に基づく高機能金属錯体触媒の開拓
科学研究費補助金(基盤研究(B))
2015 - 2017
大熊 毅
日本学術振興会, Principal investigator, Competitive research funding - Strategic Molecular and Materials Chemistry through Innovative Coupling Reactions
文部科学省特別経費 大学の特性を生かした学術研究機能の充実
Apr. 2012 - Mar. 2016
OHKUMA Takeshi
Ministry of Education, Culture, Sports, Science, and Technology, Japan, Principal investigator, Competitive research funding - Overseas Visit Program for Young Prospective Researchers Involved in Innovative Chemistry for Efficient Molecular Conversion and the Creation of New Functional Materials
Strategic Young Researcher Overseas Visits Program for Accelerating Brain Circulation
Oct. 2012 - Mar. 2015
OHKUMA Takeshi
Japan Society for the Promotion of Science, Principal investigator, Competitive research funding - Asymmetric Cyanation and Hydrogenation Catalyzed by Ruthenium Complexes
Grants-in-Aid for Scientific Research
2012 - 2014
OHKUMA Takeshi
Chiral Ru-Li combined systems developed by our research group efficiently catalyzed 1) hydrocyanation of aldehydes and N-protected aldimines, 2) cyanosilylation of simple and α-alkoxy ketones, and 3) conjugate hydrocyanation of α,β-unsaturated ketones and N-acylpyrroles. The substrate-to-catalyst molar ratio of 10,000 and enantioselectivity of 99% were achieved in the best cases.
The novel chiral Ru complexes achieved 1) very rapid and highly enantioselective hydrogenation of ketones, 2) asymmetric hydrogenation of N-arylimines, quinoxalines, and benzoxazines. The rate (turnover frequency) of the hydrogenation of ketones reached about 35,000 per minute with grater than 99% enantioselectivity. The turnover number of 18,000 and enantioselectivity of 99% in the reaction of N-arylimines were obtained in the best cases.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, Principal investigator, Competitive research funding, 24350042 - 医薬合成重要原料「光学活性プロパルギルアルコール類」の高純度合成
研究成果最適展開支援プログラム(A-STEP)(フィージビリティスタディ（探索タイプ））
Nov. 2012 - Oct. 2013
大熊 毅
科学技術振興機構, Principal investigator, Competitive research funding - 重要医薬原料「光学活性α-ヒドロキシラクトン類・エステル類」の高純度合成
研究成果最適展開支援プログラム(A-STEP)(フィージビリティスタディ（探索タイプ））
Aug. 2011 - Mar. 2012
大熊 毅
科学技術振興機構, Principal investigator, Competitive research funding - 医薬等合成原料アルケン類の高効率合成法の開発
研究成果最適展開支援プログラム(A-STEP)(フィージビリティスタディ（探索タイプ））
Oct. 2010 - Mar. 2011
大熊 毅
科学技術振興機構, Principal investigator, Competitive research funding - Asymmetric Reactions Catalyzed by Metal Complexes with two Chiral Ligands
Grants-in-Aid for Scientific Research
2009 - 2011
OHKUMA Takeshi
Chiral Ru(II) and Ir(III) complexes developped by our research groupi efficiently catalyzed 1) asymmetric cyanosilylation of aldehydes and ketones, 2) asymmetric hydrogenation of ketones, and 3) asymmetric 1,3-hydride migration of allylic alcohols : 1) Enantioselectivity as high as 99% in the reaction with a substrate-to-catalyst molar ratio (S/C) of 10,000 was achieved. 2) A series of chiral alcohols which is hardly prepared by the other methods was readily synthesized in high enantioselectivity. One of these ractions has been commercialized in the synthetic process of a chiral medicine. 3) The highest enantioselectivity of 98% in the reaction with an S/C of 1000 was achieved
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, Principal investigator, Competitive research funding, 21350048 - 医薬合成重要中間体「光学活性シアン化物」の高純度合成法の開発
平成２１年度シーズ発掘試験（発展型）
Aug. 2009 - Mar. 2010
大熊 毅
科学技術振興機構, Principal investigator, Competitive research funding - 医薬合成鍵中間体「光学活性アミノアルコール類」の高効率合成
産学共同シーズイノベーション化事業 顕在化ステージ
Dec. 2008 - Nov. 2009
大熊 毅
科学技術振興機構, Principal investigator, Competitive research funding - 医薬合成原料光学活性シアノヒドリンの高純度合成法の開発
平成２０年度シーズ発掘試験（発掘型）
Jul. 2008 - Mar. 2009
大熊 毅
科学技術振興機構, Principal investigator, Competitive research funding - Asymmetric Hydrogenation of Ketones and Imines with Poly-Coordinated Chiral Catalysts
Grants-in-Aid for Scientific Research(基盤研究(B))
2006 - 2007
Takeshi OHKUMA
A series of ruthenium complexes with both chiral diphosphine and diamine ligands was designed and applied to asymmetric hydrogenation of ketones. The obtained results are described below1) Chiral 1,4-diamine IPHAN was prepared from mannitol. The TolBINAP/IPHAN-Ru complex effectively catalyzed asymmetric hydrogenation of 1-tetralones and their analogues in a base containing 2-propanol. The reaction was completed with a substrate-to-catalyst molar ratio (S/C) as high as 55,000 to afford the chiral alcohols in up to 99% enantiomeric excess (ee). Substituted 2-cyclohexenones were also converted...
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 北海道大学, Principal investigator, Competitive research funding, 18350046 - 光学活性アルコール類の合成法の開発
大学発事業創出研究開発事業
2004 - 2006
大熊 毅
新エネルギー・産業技術総合開発機構, Principal investigator, Competitive research funding - Exploitation of Fine Molecular Catalysts
Grants-in-Aid for Scientific Research(学術創成研究費)
2002 - 2006
Ryoji NOYORI, 大熊 毅, 斎藤 進, 伊丹 健一郎
(1) Asymmetric Hydrogenation of Ketones: Chiral RuC1_2(binap)(1, 2-diamine) complexes allow rapid, enantioselective hydrogenation of various simple, unfunctionalized ketones with a high substrate/catalyst molar ratio up to 2, 400, 000. As high practicality of this procedure became recognized, we have been encouraged to develop a robust (pre)catalyst that promotes the enantioselective reaction under base-free conditions. During the course of this program, we established that RuH(η^1-BH_4)(binap)(1, 2-diamine) complexes allow for asymmetric hydrogenation of simple ketones in 2-propanol withou...
Ministry of Education, Culture, Sports, Science and Technology, 学術創成研究費, 名古屋大学, Coinvestigator not use grants, Competitive research funding, 14GS0214 - Mechanism of Asymmetric Hydrogenation of Ketones
Grants-in-Aid for Scientific Research(基盤研究(B))
2003 - 2004
Takeshi OHKUMA
Chiral diphosphine/1,2-diamine Ru(II) complexes catalyze the rapid, productive, and enantioselective hydrogenation of simple ketones. The reaction proceeds smoothly even at an atmospheric pressure of H_2 at room temperature and is further accelerated by addition of an alkaline base or a strong organic base. Most importantly, the hydrogenation rate is initially increased to a great extent with an increase in base molarity, but subsequently decreases. Without a base, the rate is independent on H_2 pressure in the range of 1-16 atm, while in the presence of a base, the reaction is accelerated ...
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 名古屋大学->北海道大学, Principal investigator, Competitive research funding, 15350079 - 新規水素化触媒の開発
産業技術実用化開発事業
2002 - 2004
大熊 毅
新エネルギー・産業技術総合開発機構, Principal investigator, Competitive research funding - 金属ナノ粒子を用いる立体選択的水素化反応の開発
基礎科学研究
2004
Competitive research funding - Development of Stereoselective Hydrogenation Catalyzed by Metal Nanoparticles
Basic Science Research Program
2004
Competitive research funding - Asymmetric Hydrogenation of Ketones and Olefins
Grants-in-Aid for Scientific Research(基盤研究(B))
2001 - 2002
Takeshi OHKUMA
Homogeneous asymmetric catalysis provides a fundamental tool for the preparation of chiral building blocks for biologically important substances and advanced materials. Polymer-bound catalysts have inherent operational and economical advantages : immobilization on solid matrices facilitates the separation from reaction mixtures, recovery, and reuse of the expensive chiral compounds. Further, the solid-phase reaction offers a technical basis for diversity-oriented combinatorial synthesis. Numerous resin-supported (pre)catalysts have been developed along this line, though their practical appl...
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 名古屋大学, Principal investigator, Competitive research funding, 13440188 - 生理機能を有する光学活性アルコール類の合成
科学研究費補助金(特定領域研究(A), 特定領域研究)
2001 - 2002
大熊 毅
本研究者の開拓した光学活性ジホスフィンとジアミンを配位子とするルテニウムジクロロ錯体は、アルカリ塩基の存在下、種々の芳香族およびα,β-不飽和ケトン類、アミノケトン類等の水素化に対して極めて高い触媒活性とエナンチオ選択性を示す。この塩化物錯体は、大気中でも安定なため操作性に優れているが、活性種を発生させるために強塩基の添加が不可欠である。したがって、塩基性条件下で不安定なケトン類の水素化には適用が困難であった。本研究では、塩基を添加せずに活性種を発生する触媒前駆体の探索研究を行った。塩化物錯体trans-RuCl_2[ (S)-xylbinap][ (S,S)-dpen](XylBINAP=2,2'-ビス(ジ-3,5-キシリルホスフィノ)-1,1'-ビナフチル、DPEN=1,2-ジフェニルエチレンジアミン)に水素化ホウ素ナトリウムを作用させることにより、ヒドリド錯体trans-RuH(η^1-BH_4)[ (S)-xylbinap][ (S,S)-dpen]を得た。この錯体は、塩基無添加条件でケトン類の水素化に対して極めて高い触媒活性とエナンチオ選択性を示した。例えば、アセトフェノンを10万分の1当量の錯体を用い、水素8気圧で水素化すると、反応は7時間で完結し、(R)-1-フェニルエタノールが99%の鏡像体過剰率で得られた。次に、塩基性条件下で容易に異性化するラセミ体α位置換シクロヘ...
文部科学省, 特定領域研究(A), 特定領域研究, 名古屋大学, Principal investigator, Competitive research funding, 13024239 - Enantioselective Hydrogenation of Ketones
Grants-in-Aid for Scientific Research(基盤研究(B))
1999 - 2000
Takeshi OHKUMA
The development of practical methods effecting stereoselective hydrogenation of simple ketones is highly desirable, since the existing homogeneous catalysts lack reactivity and/or stereoselectivity. A new Ru (II) complex, trans-RuCl_2 [ (S)-xylbinap][ (S)-daipen] or the R, R enantiomer acts as an excellent precatalyst for asymmetric hydrogenation of simple ketones (XylBINAP=2, 2'-bis (di-3, 5-xylylphosphino)-1, 1'-binaphthyl. DAIPEN=1, 1-dianisyl-2-isopropyl-1, 2-ethylenediamine). The reaction is conducted with a substrate/catalyst molar ratio of up to 100000 in 2-propanol containing alkaline...
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 名古屋大学, Principal investigator, Competitive research funding, 11440188 - 分子触媒を用いる不斉合成反応の開発
基礎科学研究
1994
Competitive research funding - Development of Asymmetric Reactions with Molecular Catalysts
Basic Science Research Program
1994
Competitive research funding
Industrial Property Rights
- 光学活性なヒドロキシエステル類またはヒドロキシアミド類の製造方法
Patent right, 大熊 毅, 新井則義, 安田俊尚, 内海典之, 片山武昭, 国立大学法人北海道大学, 関東化学株式会社
特願2020-174920, 16 Oct. 2020
特許第7650639号, 14 Mar. 2025
国立大学法人北海道大学、関東化学株式会社
13483696 - 化合物及びその製造方法
Patent right, 大熊 毅,ウシン, 百合野大雅, 国立大学法人 北海道大学
特願2025-038282, 11 Mar. 2025 - α-オキシニトリル、α-チオニトリル、α-アミノニトリル及びα-ホスファニトリルから選択されるニトリル化合物の製造方法
Patent right, 百合野 大雅, 高島 拓也, 大熊 毅, 北海道大学
特願2023-033163, 03 Mar. 2023 - Synthetic Method of Allylic Isocyanides
Patent right, Takeshi Ohkuma, Taiga Yurino, Hokkaido University; Nihonsoda
特願2017-35319, 27 Feb. 2017
特許第6871540号, 20 Apr. 2021
Hokkaido University; Nihonsoda
13483696 - 光学活性２級アルコールの製造方法
Patent right, 片山武昭, 堤 邦彦, 村田邦彦, 大熊 毅, 新井則義
特願2013-156036, 26 Jul. 2013
特開2015-24976, 05 Feb. 2015
特許第6437187号
22 Nov. 2018 - 光学活性２級アルコールの製造方法
Patent right, 片山武昭, 堤 邦彦, 村田邦彦, 大熊 毅, 新井則義
特願2013-156016, 26 Jul. 2013
特開2015-24975, 05 Feb. 2015
特許第6291179号
16 Feb. 2018 - 光学活性アミン化合物の製造方法
Patent right, 大熊 毅, 新井則義, 内海典之, 村田邦彦, 堤 邦彦
特願2013-017845, 31 Jan. 2013
特開2013-177374, 09 Sep. 2013
特許第6173702号
14 Jul. 2017 - Synthetic Method of 3-Substituted 4-Chroman-4-ols
Patent right, Takeshi Ohkuma, Noriyoshi Arai, Tsutomu Inoue, Hirohito Ooka, Keita Azuma
特願2013-177329, 28 Aug. 2013
特許第6156640号
16 Jun. 2017 - 光学活性第三級アルコール誘導体の製造方法
Patent right, 大熊 毅, 上宮暢仁, 大岡浩仁
特願2013-045569, 07 Mar. 2013
特許第6120215号
07 Apr. 2017 - 光学活性アルコール化合物の製造方法
Patent right, 明石真也, 井上 勉, 大熊 毅, 新井則義
PCT/JP2011/078816, 13 Dec. 2011
WO2012/081585, 21 Jun. 2012
特許第5616977号
19 Sep. 2014 - ジアステレオ選択的にアルコール化合物を製造する方法
Patent right, 明石真也, 井上 勉, 大熊 毅, 新井則義
PCT/JP2011/078812, 13 Dec. 2011
WO2012/081582, 12 Jun. 2012
特許第5616976号
19 Sep. 2014 - 光学活性β—ケトニトリル化合物およびその製造方法
Patent right, 大熊 毅, 黒野暢仁, 森浩幸
特願2010-26762, 09 Feb. 2010
特開2011-162477, 25 Aug. 2011
特許第5552716号
06 Jun. 2014 - β,β—ビスへテロ置換光学活性アルコールの製造方法
Patent right, 大熊 毅, 新井 則義, 井上 勉, 大岡 浩仁, 国立大学法人 北海道大学, 日本曹達株式会社
特願2006-209433, 01 Aug. 2006
特開2008-031132, 14 Feb. 2008
特許第5346434号
23 Aug. 2013
200903003028940682 - シアノ化触媒及びそれを用いた光学活性シアノヒドリン化合物類の製造方法
Patent right, 大熊 毅, 黒野暢仁
特願2008-513849, 14 Feb. 2008
特開WO2008/099965, 21 Aug. 2008
特許第5266495号
17 May 2013
PCT/JP2008/052913 - 光学活性アミノニトリル化合物およびその製造方法
Patent right, 大熊 毅, 黒野暢仁, 植村真人, 森 浩幸
特願2011-221938, 06 Oct. 2011
特開2013-082638, 09 May 2013 - 光学活性第三級アルコール誘導体の製造方法
Patent right, 大熊 毅, 上宮暢仁, 大岡浩仁
特願2013-45569, 07 Mar. 2013 - 芳香族アミン化合物の製造方法
Patent right, 大熊 毅, 新井則義, 堤 邦彦
特願2013-45958, 07 Mar. 2013 - 光学活性アルデヒドの製造方法
Patent right, 大熊 毅, 新井則義, 松村和彦
特願2013-044065, 06 Mar. 2013 - 光学活性アミン化合物の製造方法
Patent right, 大熊 毅, 新井則義, 内海典之, 村田邦彦, 堤 邦彦
特願2012-19742, 01 Feb. 2012
特開2013-177374, 31 Jan. 2013 - スルホナート触媒及びそれを利用したアルコール化合物の製法
Patent right, 内海 典之, 村田 邦彦, 堤 邦彦, 片山 武昭, 渡辺 正人, 大熊 毅, 野依 良治, 関東化学株式会社, 財団法人名古屋産業科学研究所
JP2006304750, 10 Mar. 2006
WO2006-137195, 28 Dec. 2006
特許第5087395号
14 Sep. 2012
200903051762733888 - 光学活性アミンの製造方法
Patent right, 大熊 毅, 新井則義, 松村和彦
特願2012-197246, 07 Sep. 2012 - 光学活性α−ヒドロキシシラン類の製造方法及び新規な光学活性α−ヒドロキシシラン類化合物
Patent right, 大熊 毅, 新井 則義, 鈴木 賢, 国立大学法人 北海道大学
特願2007-032105, 13 Feb. 2007
特開2008-195647, 28 Aug. 2008
特許第5050202号
13 Aug. 2012
特願 2007-032105, 200903029301710562 - 光学活性キヌクリジノール類の製造方法
Patent right, 野依 良治, 大熊 毅, 堤 邦彦, 内海 典之, 村田 邦彦, 片山 武昭, 関東化学株式会社, 財団法人名古屋産業科学研究所
JP2005006048, 30 Mar. 2005
WO2006-103756, 05 Oct. 2006
特許US 8,212,037 B2
03 Jul. 2012
200903095876947133 - シアノ化触媒及びそれを用いた光学活性シアンヒドリン化合物類の製造方法
Patent right, 大熊 毅, 黒野 暢仁, 国立大学法人北海道大学, 三菱レイヨン株式会社
JP2008052913, 14 Feb. 2008
WO2008-099965, 21 Aug. 2008
特許US 8,163,947 B2
24 Apr. 2012
201003070007051993 - ルテニウムヒドリド錯体
Patent right, 大熊 毅, 小泉 昌稔, キリアン・ムニツ, 野依 良治, 日本曹達株式会社
特願2011-281984, 22 Dec. 2011
特開2012-056969, 22 Mar. 2012
201203045224174017 - 水素化促進剤、水素化触媒及びアルケン化合物の製法
Patent right, 堀 順一, 村田 邦彦, 黒野 暢仁, 大熊 毅, 野依 良治, 関東化学株式会社, 財団法人名古屋産業科学研究所
特願2011-243193, 07 Nov. 2011
特開2012-035264, 23 Feb. 2012
201203000591529308 - 光学活性β−ケトニトリル化合物およびその製造方法
Patent right, 大熊 毅, 黒野 暢仁, 森 浩幸, 国立大学法人北海道大学, 三菱レイヨン株式会社
特願2010-026762, 09 Feb. 2010
特開2011-162477, 25 Aug. 2011
201103085467467220 - 光学活性シアノヒドリン化合物類およびその製造方法
Patent right, 大熊 毅, 黒野 暢仁, 植村 真人, 森 浩幸, 国立大学法人北海道大学, 三菱レイヨン株式会社
特願2009-258736, 12 Nov. 2009
特開2011-102282, 26 May 2011
201103019326011092 - 光学活性アルコール化合物の製造方法
Patent right, 明石真也, 井上 勉, 大熊 毅, 新井則義
特願2011-92511, 18 Apr. 2011 - 光学活性アルコールの製法
Patent right, 野依 良治, 大熊 毅, 堤 邦彦, 内海 典之, 村田 邦彦, 財団法人名古屋産業科学研究所, 関東化学株式会社
JP2004004422, 29 Mar. 2004
WO2005-092825, 06 Oct. 2005
特許第4722037号
15 Apr. 2011
200903068105869834 - 光学活性アルコールの製法
Patent right, 野依 良治, 大熊 毅, 堤 邦彦, 内海 典之, 村田 邦彦, 関東化学株式会社, 財団法人名古屋産業科学研究所
特願2010-167292, 26 Jul. 2010
特開2010-285443, 24 Dec. 2010
201103000722943523 - 光学活性アルコール化合物合成用触媒
Patent right, 碇屋 隆雄, 池平 秀行, 村田 邦彦, 清藤 信夫, 大岡 浩仁, 橋口 昌平, 大熊 毅, 野依 良治, 独立行政法人科学技術振興機構, JFEスチール株式会社, 関東化学株式会社, 高砂香料工業株式会社, 日本曹達株式会社, 武田薬品工業株式会社
特願2007-165566, 22 Jun. 2007
特開2007-283302, 01 Nov. 2007
特許第4637876号
03 Dec. 2010
201103040660653584 - 水素化促進剤、水素化触媒及びアルケン化合物の製法
Patent right, 堀 順一, 村田 邦彦, 黒野 暢仁, 大熊 毅, 野依 良治, 財団法人名古屋産業科学研究所, 関東化学株式会社
JP2005006694, 30 Mar. 2005
WO2005-094993, 13 Oct. 2005
特許US7,619,125 B2
17 Nov. 2009
200903003861485239 - 光学活性3−キヌクリジノール誘導体の製造方法
Patent right, 大熊 毅, 新井 則義, 明石 真也, 大岡 浩仁, 井上 勉, 国立大学法人北海道大学, 日本曹達株式会社
JP2008065746, 02 Sep. 2008
WO2009-031526, 12 Mar. 2009
201003070731318276 - 光学活性３−キヌクリジノール誘導体の製造方法
Patent right, 大熊 毅, 新井則義, 明石真也, 大岡浩仁, 井上 勉
特願2008-32311, 13 Feb. 2008
特開WO2009/031526 A1, 12 Mar. 2009
PCT/JP2008/065746 - 光学活性アルコール化合物の製造方法
Patent right, 野依 良治, 三上 幸一, 大熊 毅, 寺田 眞浩, ヘンリ ドゥセ, ファム ティ, マイ, ジャン, カソリーヌ, 是永 敏伸, 伊藤 雅通, 佐用 昇, 長谷川香料株式会社, 高砂香料工業株式会社
特願平9-241119, 05 Sep. 1997
特開平11-080053, 23 Mar. 1999
特許第4144814号
27 Jun. 2008
200903095748243484 - ルテニウム錯体及びこれを用いるtert−アルキルアルコールの製造方法
Patent right, 大熊 毅, クリスチャン, アンブロシオ, サンドバル, 野依 良治, 関東化学株式会社, 財団法人名古屋産業科学研究所
JP2005019497, 24 Oct. 2005
WO2006-046508, 04 May 2006
特許US 7,378,560 B2
27 May 2008
200903090006052791 - 光学活性アルコール類の製造方法
Patent right, 池平 秀行, 村田 邦彦, 碇屋 隆雄, 大熊 毅, 野依 良治, 独立行政法人科学技術振興機構, 住友化学株式会社, 関東化学株式会社, JFEスチール株式会社
特願平9-359655, 26 Dec. 1997
特開平11-189558, 13 Jul. 1999
特許第4052702号
14 Dec. 2007
200903092166879210 - アルコール類の製造方法
Patent right, 池平 秀行, 村田 邦彦, 碇屋 隆雄, 大熊 毅, 野依 良治, 独立行政法人科学技術振興機構, 住友化学株式会社, 関東化学株式会社, JFEスチール株式会社
特願平9-359656, 26 Dec. 1997
特開平11-189559, 13 Jul. 1999
特許第4052703号
14 Dec. 2007
200903058419931210 - 触媒組成物
Patent right, 碇屋 隆雄, 池平 秀行, 村田 邦彦, 清藤 信夫, 大岡 浩仁, 橋口 昌平, 大熊 毅, 野依 良治, 独立行政法人科学技術振興機構, JFEスチール株式会社, 関東化学株式会社, 高砂香料工業株式会社, 日本曹達株式会社, 武田薬品工業株式会社
特願2007-165566, 22 Jun. 2007
特開2007-283302, 01 Nov. 2007
200903025683341876 - ルテニウム錯体を触媒とするアルコール化合物の製造方法
Patent right, 碇屋 隆雄, 池平 秀行, 村田 邦彦, 清藤 信夫, 大岡 浩仁, 橋口 昌平, 大熊 毅, 野依 良治, 独立行政法人科学技術振興機構, 住友化学株式会社, JFEスチール株式会社, 関東化学株式会社, 高砂香料工業株式会社, 日本曹達株式会社, 武田薬品工業株式会社
特願平9-359654, 26 Dec. 1997
特開平11-189600, 13 Jul. 1999
特許第4004123号
31 Aug. 2007
201103012636304974 - 光学活性キヌクリジノールの製造方法
Patent right, 大熊 毅, 新井則義, 明石真也, 大岡浩仁, 井上 勉
特願2007-230973, 2007 - 水素化触媒及びそれを利用したアルコール化合物の製法
Patent right, 内海 典之, 村田邦彦, 堤 邦彦, 片山 武昭, 大熊 毅, 野依 良治
PCT/JP2005/011674, 20 Jun. 2005
WO2006/137165, 28 Dec. 2006 - スルホナート触媒及びそれを利用したアルコール化合物の製法
Patent right, 内海 典之, 村田 邦彦, 堤 邦彦, 片山 武昭, 大熊 毅, 野依 良治
PCT/JP2005/011679, 20 Jun. 2005
WO2006/137167, 28 Dec. 2006 - シリルシアノ化触媒及びシアノヒドリンシリルエーテル化合物の製法
Patent right, 大熊 毅, 黒野 暢仁, 国立大学法人 北海道大学
特願2005-036430, 14 Feb. 2005
特開2006-219457, 24 Aug. 2006
200903072721454319 - ルテニウムヒドリド錯体、アルコール化合物の製造方法およびラセミ体カルボニル化合物の分割方法
Patent right, 堤 邦彦, 村田 邦彦, 内海 典之, 大熊 毅, 野依 良治, 財団法人名古屋産業科学研究所
特願2003-027409, 04 Feb. 2003
特開2004-238306, 26 Aug. 2004
200903043357222857 - 水素化触媒及びアルケン化合物の製造方法
Patent right, 大熊 毅, 吉田 誠, 野依 良治, 財団法人名古屋産業科学研究所
特願2002-034427, 12 Feb. 2002
特開2003-236386, 26 Aug. 2003
200903090993414306 - ルテニウムヒドリド錯体、アルコール化合物の製造方法およびラセミ体カルボニル化合物の分割方法
Patent right, 大熊 毅, 小泉 昌稔, キリアン・ムニツ, 野依 良治, 財団法人名古屋産業科学研究所
特願2001-301852, 28 Sep. 2001
特開2003-104993, 09 Apr. 2003
200903045009512127 - ルテニウム錯体及びアルコール化合物の製造方法
Patent right, 大熊 毅, 武野 泰士, 野依 良治, 財団法人名古屋産業科学研究所
JP2002000946, 06 Feb. 2002
WO2002-062809, 15 Aug. 2002
200903086654383542 - トランス−3−イソカンフィルシクロヘキサノールの製造法
Patent right, 江村 誠, 豊田 高明, 清藤 信夫, 原田 睦, 野依 良治, 碇屋 隆雄, 大熊 毅, 高砂香料工業株式会社
特願平8-050309, 07 Mar. 1996
特開平9-241195, 16 Sep. 1997
特許第3281532号
22 Feb. 2002
200903027096436409 - 窒素あるいは酸素官能基を有する光学活性第二級アルコール類の製造法
Patent right, 中野 誠志, 野依 良治, 大熊 毅, 石井 大, 旭化成株式会社
JP2001000797, 05 Feb. 2001
WO2001-058843, 16 Aug. 2001
200903057145505167 - アルコール類の製造法
Patent right, 池平 秀行, 村田 邦彦, 片山 栄治, 小沢 征巳, 横澤 亨, 大熊 毅, 碇屋 隆雄, 野依 良治, 科学技術振興事業団, 住友化学工業株式会社, 関東化学株式会社, 日産化学工業株式会社, 高砂香料工業株式会社, 日本曹達株式会社
特願平10-358034, 16 Dec. 1998
特開2000-178215, 27 Jun. 2000
200903092957524530 - 光学活性な1−(4−イソブチルフェニル)ブタン−1−オールの製造方法
Patent right, 寺島 幸司, 大熊 毅, 野依 良治, 野依 良治, 大原薬品工業株式会社
特願平10-202798, 01 Jul. 1998
特開2000-026344, 25 Jan. 2000
200903078336439463 - ルテニウム錯体とこれを触媒とするアルコール化合物 の製造方法
Patent right, 碇屋 隆雄, 池平 秀行, 村田 邦彦, 清藤 信夫, 大岡 浩仁, 橋口 昌平, 大熊 毅, 野依 良治, 科学技術振興事業団, 日本鋼管株式会社, 住友化学工業株式会社, 関東化学株式会社, 高砂香料工業株式会社, 日本曹達株式会社, 武田薬品工業株式会社
特願平9-359654, 26 Dec. 1997
特開平11-189600, 13 Jul. 1999
200903095374170593 - アルコール類の製造方法
Patent right, 碇屋 隆雄, 大岡 浩仁, 橋口 昌平, 大熊 毅, 清藤 信夫, 野依 良治, 科学技術振興事業団, 高砂香料工業株式会社, 日本鋼管株式会社, 日本曹達株式会社, 武田薬品工業株式会社
特願平7-316560, 05 Dec. 1995
特開平8-225467, 03 Sep. 1996
特許第2935453号
04 Jun. 1999
200903084531455201 - 光学活性アルコール類の製造方法
Patent right, 池平 秀行, 碇屋 隆雄, 大熊 毅, 野依 良治, 科学技術振興事業団, 住友化学工業株式会社, 日本鋼管株式会社
特願平9-079539, 31 Mar. 1997
特開平10-273456, 13 Oct. 1998
200903040307907574 - アルコール類の製造方法
Patent right, 池平 秀行, 碇屋 隆雄, 大熊 毅, 野依 良治, 科学技術振興事業団, 住友化学工業株式会社, 日本鋼管株式会社
特願平9-079538, 31 Mar. 1997
特開平10-273455, 13 Oct. 1998
200903057712298496 - 4―アミノ―3―ヒドロキシカルボン酸類の立体選択的合成法
Patent right, 野依 良治, 北村 雅人, 大熊 毅, 森沢 靖弘, 西 剛秀, 三共株式会社
特願平1-060543, 13 Mar. 1989
特開平2-009849, 12 Jan. 1990
特許第2804284号
17 Jul. 1998
201103068233260603 - 光学活性γ―ブチロラクトン誘導体の製造方法
Patent right, 野依 良治, 北村 雅人, 大熊 毅, 佐用 昇, 雲林 秀徳, 高砂香料工業株式会社
特願平2-228957, 30 Aug. 1990
特開平4-108782, 09 Apr. 1992
特許第2796884号
03 Jul. 1998
201103026436358035 - 光学活性アルコール類の製造方法
Patent right, 碇屋 隆雄, 大岡 浩仁, 橋口 昌平, 大熊 毅, 清藤 信夫, 野依 良治, 科学技術振興事業団, 碇屋 隆雄, 大岡 浩仁, 橋口 昌平, 清藤 信夫
特願平7-316559, 05 Dec. 1995
特開平8-225466, 03 Sep. 1996
特許第2731377号
19 Dec. 1997
200903088720021161 - シス−4−t−ブチルシクロヘキサノールの製造法
Patent right, 江村 誠, 豊田 高明, 清藤 信夫, 野依 良治, 碇屋 隆雄, 大熊 毅, 高砂香料工業株式会社
特願平8-050310, 07 Mar. 1996
特開平9-241194, 16 Sep. 1997
200903062352658244 - シリルエーテル類の製造法
Patent right, 大熊 毅, 橋口 昌平, 碇屋 隆雄, 野依 良治, 新技術事業団, 橋口 昌平, 碇屋 隆雄
特願平5-245801, 30 Sep. 1993
特開平7-101964, 18 Apr. 1995
200903058028769630 - 光学活性アルコールおよびその誘導体の製造方法
Patent right, 野依 良治, 北村 雅人, 大熊 毅, 雲林 秀徳, 高砂香料工業株式会社
特願昭63-037032, 19 Feb. 1988
特開平1-211551, 24 Aug. 1989
201103077902736790 - 光学活性シアノヒドリン化合物類およびその製造方法
Patent right
特願2009-258736 - 光学活性キヌクリジノールの製造方法
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US7,601,667 B2 - ルテニウム錯体及びこれを用いるtert-アルキルアルコールの製造方法
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US7,378,560 B2 - 水素化触媒及びそれを利用したアルコール化合物の製法
Patent right
WO2006/137165 - スルホナート触媒及びそれを利用したアルコール化合物の製法
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WO2006/137167 - 光学活性キヌクリジノール類の製造方法
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WO2006/103756 A1 - 水素化促進剤、水素化触媒及びアルケン化合物の製法
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WO2005/094993 A1 - シリルシアノ化触媒及びシアノヒドリンシリルエーテル化合物の製法
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特開2006-219457 - 光学活性アルコールの製法
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PCT/JP2008/065746 - Synthesis of optically active cyanohydrin derivatives
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WO2003/068391
