Uchida Tsutomu

Faculty of Engineering　Applied Physics　Complex Material PhysicsAssociate Professor
Institute for the Advancement of Higher EducationAssociate Professor
Last Updated :2026/02/05

■Researcher basic information

Researchmap personal page

Home Page URL

Research Field

  • Natural sciences, Bio-, chemical, and soft-matter physics
  • Nanotechnology/Materials, Nanomaterials
  • Nanotechnology/Materials, Basic physical chemistry

Educational Organization

■Career

Career

  • Mar. 2004 - Present
    Hokkaido University, Faculty of Engineering, Division of Applied Physics, Associate Professor

■Research activity information

Awards

  • Sep. 2012, （公社）日本雪氷学会, 学術賞　　　　　　　　　　　　　　　
    ガスハイドレートの生成過程とガス包接機構に関する基礎的研究
    内田 努
  • Oct. 2002, Japanese Society of Snow and Ice, The JSSI Hirata Award　　　　　　　　　　　　　　　
    Studies on the physical properties of gas hydrates in ice
    UCHIDA Tsutomu
  • Feb. 2000, Japanese Insitute of Energy, 2000: The JIE Progress Award　　　　　　　　　　　　　　　
    Studies on gas hydrates via Raman spectroscopy
    UCHIDA Tsutomu

Papers

Other Activities and Achievements

Books and other publications

  • 日本のガスハイドレート研究の歩み～黎明期から最先端まで～　　　　　　　　　　　　　　　
    一社, 日本エネルギー学会, 天然ガス部会, 資源分科会, GH 研究会編集委員会, 編集委員長、分担執筆：p. 7～22、39～42、75～77
    日本工業出版（株）, Sep. 2020, [Editor]
  • Fossil Fuels　　　　　　　　　　　　　　　
    MASUDA Yoshihiro, UCHIDA Tsutomu, NAGAKUBO Sadao, SATOH Mikio, Vol. 1, Chapter 10, Methane Hydrates
    World Scientific Pub. Co. Pte. Ltd., Jun. 2017, 9789814699976, [Contributor]
  • Handbook of Low Temperature Science　　　　　　　　　　　　　　　
    UCHIDA Tsutomu, 氷と雪の基礎科学
    Maruzen, Oct. 2015, [Contributor]
  • 非在来型天然ガスのすべて エネルギー資源の新たな主役（コールベッドメタン・シェールガス・メタンハイドレート）　　　　　　　　　　　　　　　
    内田 努, 編集委員会副委員長、分担執筆
    日本工業出版, May 2014, [Editor]
  • 新版 雪氷辞典　　　　　　　　　　　　　　　
    内田 努, 物性部門編集、分担執筆
    古今書院, 2014, [Editor]
  • Bio-Nanotechnology: A Revolution in Biomedical Sciences, & Human Health　　　　　　　　　　　　　　　
    UCHIDA Tsutomu, Chapter 29: Basic Characterization of Nanobubbles and Its Potential Applications
    John Wiley & Sons, Ltd., Feb. 2013, [Contributor]
  • Crystal Growth, Book 2　　　　　　　　　　　　　　　
    UCHIDA Tsutomu, Chapter 9: Freezing properties of disaccharide solutions: inhibition of hexagonal ice crystal growth and formation of cubic ice
    InTech, Jan. 2012, [Contributor]
  • Physics and Chemistry of Ice, 2010
    International, Symposium on the Physics, Chemistry of Ice, 古川 義純, 佐崎 元, 内田 努, Watanabe Naoki
    Hokkaido University Press, 2011, 9784832903616, xi, 472 p., English

Lectures, oral presentations, etc.

  • Observations of Micro- and Nano-bubbles and their accelaration effect on crystallization　　　　　　　　　　　　　　　
    UCHIDA Tsutomu
    LASOR seminar, 19 Dec. 2018, Japanese, Public discourse
    [Invited], [Domestic Conference]
  • Xenon plays inhibition roles on the neuronal network activities　　　　　　　　　　　　　　　
    T. Uchida, K. Shimada, R. Tanabe, T. Kubota, D. Ito, K. Yamazaki, K. Gohara
    2nd International Aquaphotomics Symposium,, 28 Nov. 2016, English, Oral presentation
    [Invited], [International presentation]
  • トレハロースの氷晶成長抑制機構～水溶液の凍結過程と凍結保護作用の観測～　　　　　　　　　　　　　　　
    内田 努
    第20回トレハロースシンポジウム, 17 Nov. 2016, Japanese, Poster presentation
    [Invited], [Domestic Conference]
  • １．農産物や食品の低温保存技術への応用技術seeds;「水溶液の凍結制御技術」「（2）ナノバブルによる結晶化促進効果」　　　　　　　　　　　　　　　
    内田 努
    グリーンテクノバンクUnmet needsワークショップ, 26 Oct. 2016, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • トレハローストランスポーターを発現したCHO-K1細胞の凍結保条件　　　　　　　　　　　　　　　
    内田 努, 古川真帆, 黄川田隆洋, 山崎憲慈, 郷原一寿
    28 Oct. 2015, Japanese, Oral presentation
    [Invited], [Domestic Conference]
  • ガスハイドレート溶解時のナノバブル発生と再結晶化過程におけるメモリー効果　　　　　　　　　　　　　　　
    内田 努, 山崎憲慈, 郷原一寿
    日本地球惑星科学連合2015年大会, 27 May 2015, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • 氷を制御して生物の活性を制御する　　　　　　　　　　　　　　　
    内田 努
    2014年度雪氷物性分科会シンポジウム, 20 Sep. 2014, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • 生物の中の水を制御する　　　　　　　　　　　　　　　
    内田 努
    鮮度保持技術に関する意見交換会, 01 Aug. 2014, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • Analysis and control of cultured neuronal networks using multi-electrode arrays: from gene expression to network dynamics　　　　　　　　　　　　　　　
    D. Ito, K. Yokoyama, T. Uchida, K. Gohara
    IVth Int. Conf. Topical Problems in Biophotonics 2013, 22 Jul. 2013, English, Invited oral presentation
    [Invited], [International presentation]
  • トレハロースの氷晶成長抑制機構～水溶液の凍結過程と凍結保護作用の観測～　　　　　　　　　　　　　　　
    内田 努
    第16回トレハロースシンポジウム, 25 Oct. 2012, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • Gas Structured Water: From Gas Hydrates to Cellular Activity Inhibition　　　　　　　　　　　　　　　
    UCHIDA Tsutomu
    WINPTech2011, “Water and Light” session, 02 Dec. 2011, English, Nominated symposium
    [Invited], [International presentation]
  • 混合ガスハイドレートの分解挙動の組成依存性　　　　　　　　　　　　　　　
    内田 努
    第６回GHIC講演会, 19 Jan. 2011, Japanese, Public discourse
    [Invited], [Domestic Conference]
  • 凍結割断レプリカ法による糖の凍結抑制作用の観測　　　　　　　　　　　　　　　
    内田 努
    平成22年度日本顕微鏡学会北海道支部学術講演会, 11 Dec. 2010, Japanese, Invited oral presentation
    [Invited], [Domestic Conference]
  • トレハロース水溶液凍結時に観測された氷Ic結晶相の形成過程　　　　　　　　　　　　　　　
    内田 努
    日本物理学会2010年秋季大会・領域9，12合同シンポジウム, 24 Sep. 2010, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • マイクロ・ナノバブルの電子顕微鏡観察　　　　　　　　　　　　　　　
    内田 努
    農林水産・食品産業マイクロ・ナノバブル技術研究組合平成22年度通常総会講演会, 31 May 2010, Japanese, Public discourse
    [Invited], [Domestic Conference]
  • 氷・クラスレートハイドレートの透過型電子顕微鏡観測　　　　　　　　　　　　　　　
    内田 努
    平成21年度日本顕微鏡学会北海道支部学術講演会, 12 Dec. 2009, Japanese, Invited oral presentation
    [Invited], [Domestic Conference]
  • ガスハイドレートの形成過程と水溶液の構造化　　　　　　　　　　　　　　　
    内田 努
    日本分析化学会第58回年会, 24 Sep. 2009, Japanese, Invited oral presentation
    [Invited], [Domestic Conference]
  • 水の構造化 ―クラスレートハイドレートから細胞へ―　　　　　　　　　　　　　　　
    内田 努
    2006年度第6回水科学研究会, 09 Dec. 2006, Japanese, Nominated symposium
    [Invited], [Domestic Conference]

Affiliated academic society

  • JAPAN SOCIETY OF THERMOPHYSICAL PROPERTIES　　　　　　　　　　　　　　　
  • THE JAPANESE SOCIETY OF MICROSCOPY　　　　　　　　　　　　　　　
  • JAPANESE SOCIETY FOR CRYOBIOLOGY AND CRYOTECHNOLOGY　　　　　　　　　　　　　　　
  • THE BIOPHYSICAL SOCIETY OF JAPAN　　　　　　　　　　　　　　　
  • THE JAPAN INSTITUTE OF ENERGY　　　　　　　　　　　　　　　
  • JAPANESE ASSOCIATION FOR CRYSTAL GROWTH　　　　　　　　　　　　　　　
  • THE JAPANESE SOCIETY OF SNOW AND ICE　　　　　　　　　　　　　　　

Research Themes

  • 細胞内水の状態観測による凍結保存メカニズムの再検討　　　　　　　　　　　　　　　
    科学研究費助成事業 挑戦的研究(萌芽)
    30 Jun. 2022 - 31 Mar. 2025
    内田 努
    日本学術振興会, 挑戦的研究(萌芽), 北海道大学, 22K18678
  • Development of advanced technology for cell cryopreservation　　　　　　　　　　　　　　　
    Adaptable and Seamless Technology Transfer Program through Target-driven R&D
    Sep. 2019 - Mar. 2021
    UCHIDA Tsutomu
    Japan Science and Technology Agency, Principal investigator, Competitive research funding
  • 抗氷核活性を利用した農産物の品質保持や凍結制御の技術開発　　　　　　　　　　　　　　　
    Hokudai Robust
    May 2019 - Mar. 2020
    ARAKAWA Keita
    Hokkaido University, Competitive research funding
  • ガスハイドレートの再生成過程促進に係るウルトラファインバブルの効果　　　　　　　　　　　　　　　
    第38回（2018年度）研究助成
    Apr. 2019 - Mar. 2020
    内田 努
    （公財）東燃ゼネラル石油研究奨励・奨学財団, Principal investigator, Competitive research funding
  • Nano-Structure 3D Atomic Imaging using Electron Diffraction
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    10 Jul. 2014 - 31 Mar. 2019
    GOHARA Kazutoshi, SAKAGUCHI Norihito, UCHIDA Tsutomu, YAMAZAKI Kenji, MAEHARA Yosuke
    In order to clarify the active site with atomic resolution, we aimed at the development and application of atomic resolved nanostructure imaging method by electron microscope.
    In subject 1, we advanced the development of imaging using electron diffraction and construction of experimental method for application. Furthermore, we developed a new algorithm on the ensemble averaging method in real space and Fourier space. In subject 2, experimental verification of atomic resolved imaging using an aberration corrected electron microscope was carried out. Using X-ray diffraction together, several important results regarding structure and function were obtained for the several objects. In subject 3, we studied three-dimensional atomic resolved imaging of nanostructures on graphene. We succeeded in dispersing single atoms on graphene without agglomeration. Atomic arrangement and local electronic state of Pt atom were revealed. We found the active site of atoms, molecules and clusters.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Hokkaido University, 26105009
  • 抗氷核活性を利用した農産物の品質保持や凍結制御の技術開発　　　　　　　　　　　　　　　
    Hokudai Robust
    Oct. 2018 - Mar. 2019
    ARAKAWA Keita
    Hokkaido University, Competitive research funding
  • Studies on cryopreservation mechanism of intracellular trehalose introduced through trehalose transporter
    Grants-in-Aid for Scientific Research Challenging Research (Exploratory)
    Jul. 2017 - Mar. 2019
    Uchida Tsutomu
    In this study, we aimed to clarify the mechanism of the high cryoprotective effect of intracellular trehalose experimentally. Since trehalose is not transported into the cell spontaneously, we used two CHO-K1 cells as the model cell, one of which is expressing the trehalose transporter (TRET1) and another is not. It has been thought that the intracellular water was vitrified by the intracellular trehalose, but the results of powder X-ray diffraction and differential calorimetry merely indicates the existence of ice Ih crystal below the melting point. The results of THz spectroscopy show the possibility of the presence of a liquid phase at that low temperature conditions. More detailed examinations by these measurement methods are necessary in the future.
    JSPS, Grant-in-Aid for Challenging Research (Exploratory), Hokkaido University, Principal investigator, Competitive research funding, 17K18834
  • 第9回国際ガスハイドレート会議（ICGH9）　　　　　　　　　　　　　　　
    平成28年度国際交流（派遣）助成金
    Jun. 2017 - Jul. 2017
    内田 努
    （一財）向科学技術振興財団, Principal investigator, Competitive research funding
  • 農林水産系のファインバブル技術開発　　　　　　　　　　　　　　　
    戦略的イノベーション創造プログラム（次世代農林水産業創造技術）
    Oct. 2014 - Mar. 2017
    内田 努
    総合科学技術・イノベーション会議, Principal investigator, Competitive research funding
  • ニューラルネットワークの信号伝達がガス分子によって抑制される機構の解明　　　　　　　　　　　　　　　
    科学研究費補助金事業
    Apr. 2011 - Mar. 2014
    内田 努
    Principal investigator, Competitive research funding
  • Morphological approach relates to the stabilization of nanobubbles
    Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
    2013 - 2014
    UCHIDA Tsutomu
    This study aims to confirm that nanobubbles (NBs) have sufficient lifetime, and to reveal the factors that prolong the life NB and the physical properties measurement of solute of the surrounding. In 2014 FY, the effects of the additive (NaCl) to the lifetime of the oxygen NB were evaluated by electron microscope observation using the freeze fracture replica method. Results indicated that the number of NB decreased and their diameters increased depending on the storage period of the solution. A thin layer was observed on stored NBs. These results suggested that a small amount of NaCl tended to concentrate around the bubble, which might stabilize the bubble.
    Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, Principal investigator, Competitive research funding, 25600035
  • メタンハイドレートの科学技術開発に関する国際会議　　　　　　　　　　　　　　　
    総長室事業推進経費（公募型プロジェクト研究等支援経費）「国際研究集会等開催支援」
    Aug. 2011 - Mar. 2013
    内田 努
    北海道大学, Principal investigator, Competitive research funding
  • Studies on inhibition mechanism of synchronized bursts in neuronal network
    Grants-in-Aid for Scientific Research(基盤研究(B))
    2011 - 2013
    Tsutomu UCHIDA, Kazutoshi GOHARA, Masafumi NAGAYAMA
    In order to understand the mechanism of general anesthesia with Xe, we carried out the mesoscopic and microscopic measurements on cultured neuronal network from rat cortex. We measured the activity depression of cultured neuronal network under Xe gas pressure by multi-electrode arrays (mesoscopic measurement) and by a Raman spectroscopy (microscopic measurement). When we applied Xe gas between 0.1 and 0.5 MPa on cultured neuronal network, the characteristic firing activity (synchronized burst firing) was completely inhibited under the conditions of Xe pressure higher than 0.3 MPa. Raman spectra of neurons showed the peak shift of C-H stretching mode of the cell membranes under Xe pressure, which indicated that Xe molecules dissolved in membranes. This indication coincides with that suggested by MD simulation.
    Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 北海道大学, Principal investigator, Competitive research funding, 23350001
  • マイクロ・ナノバブルの形態と安定性に関する研究　　　　　　　　　　　　　　　
    平成23年度第2回学術研究助成事業
    Sep. 2011 - Mar. 2012
    内田 努
    （財）前川報恩会, Principal investigator, Competitive research funding
  • Measurement and control for multiscale-spatiotemporal neurodynamics
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
    2008 - 2011
    GOHARA Kazutoshi, UCHIDA Tutomu, NAGAYAMA Masafumi, SHIOYA Hiroyuki
    This project has challenged to measurement and control of multi-scale spatiotemporal neuronal dynamics, three-figure spatially and ten-figure temporally. The aim of the project is as follows ; long term culture on multi-electrode array, detection of impulses, observation of way of growing neuronal networks, and analysis of obtained data. As a result, we established long term primary neuronal dissociative cell culture on multi-electrode arrays. Moreover, immunocytochemistry of some proteins was also established for main parts of neuron during several month. The main subject of construction of experimental systems to attack basic problems in neuroscience was achieved. Using constructed system, we obtained important issues of the related field. One of the results is a minimum density of surviving neurons that caused synchronized bursts. Further development of the present works is expected to execute the future fruitful studies on spatiotemporal neuronal dynamics.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Hokkaido University, 20240023
  • ガス印加法による細胞の常温保存技術の開発　　　　　　　　　　　　　　　
    地域イノベーション創出総合支援事業 重点地域研究開発支援プログラムシーズ発掘試験
    Aug. 2009 - Mar. 2010
    内田 努
    （独）科学技術振興機構（JST）, Principal investigator, Competitive research funding
  • 天然ガスハイドレートの焼結現象の観察　　　　　　　　　　　　　　　
    平成21年度北海道ガス大学研究支援制度
    Jul. 2009 - Mar. 2010
    内田 努
    北海道ガス, Principal investigator, Competitive research funding
  • ジェネティック・ニューロダイナミクスの開拓
    科学研究費助成事業 挑戦的萌芽研究
    2009 - 2010
    郷原 一寿, 内田 努, 永山 昌史
    今年度は、研究実施計画に沿って、1.蛍光染色条件の絞り込み、2.既知タンパク質の発現時期同定法、3.ブロッカーによる特定タンパク質のブロック法、4.ニューロダイナミクスの解析法について研究を進めた。1については、抑制性シナプス、興奮性シナプスをそれぞれ、VGluT1、VGATで再現良く染色することを可能とする手法を確立した。2については、ニューロンの核、軸索、樹状突起に加えて、抑制性シナプス、興奮性シナプスのそれぞれに特異的なタンパク質の発現量を2ヶ月の長期に渡って定量的に計測することが可能となった。3については、ピペッティングによるブロッカの注入、インパルス測定、ブロッカの除去、インパルス測定の手順を繰り返すことにより、再現性が保証できる実験条件を、特定タンパク質に対して試みたが、実験回数が十分でなく再現性についての課題が残った。4については、平均発火、同期バースト、リターンマップ、相関などの主要時系列データの解析が可能となった。
    研究成果の一部は、多電極アレイに関する最大規模の国際会議(MEA Meeting 2010、ドイツ、参加国数20,2010年7月)において発表され、数多くある候補の中から論文中の蛍光染色イメージの一つが"the most impressive image"としてProceedingの表紙に採択された。また、本研究で得られた1,2,4に関する結果の一部は、同期バーストに必要なネットワークの最小サイズに関する論文(Neuroscience 171,50-61,2010.)においてまとめられた。また、論文中の蛍光染色イメージの一つが、Neuroscience誌(論文の掲載号)の表紙を飾った。
    日本学術振興会, 挑戦的萌芽研究, 北海道大学, 21650049
  • ガスハイドレート自己保存効果発現条件の高度化　　　　　　　　　　　　　　　
    ゼネラル石油研究奨励財団研究助成
    Mar. 2008 - Mar. 2009
    内田 努
    ゼネラル石油研究奨励財団, Principal investigator, Competitive research funding
  • 第6回ガスハイドレート国際会議（カナダ国バンクーバー市）　　　　　　　　　　　　　　　
    平成20年度国際学会等派遣事業
    Jul. 2008 - Jul. 2008
    内田 努
    日本学術振興会, Principal investigator, Competitive research funding
  • 第6回メタンハイドレート研究技術開発に係る国際ワークショップ国際ワークショップ（ノルウェー国ベルゲン市）　　　　　　　　　　　　　　　
    研究者海外派遣助成
    May 2008 - May 2008
    内田 努
    池谷科学技術振興財団, Principal investigator, Competitive research funding
  • Regulating cell behaviors by structurization of intra-/extra-cellular water
    Grants-in-Aid for Scientific Research
    May 2005 - Mar. 2008
    UCHIDA Tsutomu, GOHARA Kazutoshi, NAGAYAMA Masafumi
    The project aimed to reveal the role of water playing on the signal transfer processes between neural cells or cardinal cells by water structurization. For this purpose, we studied the following two themes: 1) observations of the signal transfer in the cellular network and effects of temperature, pressure or composition of culturing circumstances including the clathrate forming components, and 2) development of the observation techniques on the structurized water between cells.
    In theme 1), we introduced the measurement system of electronic signals propagating in the cellular network. This system could control the culture conditions (temperature, pressure or compositions of vapor) independently. We observed these conditions effecting on the neural and cardinal cellular networks, especially low temperature and high pressure conditions which might lead the structurization of water, or form clathrate hydrates.
    In theme 2), we developed the observation system for structurized water via electron microscope. We first observed the replica samples of freeze-fractured surface on trehalose solution, which is known as one of the cryo-preservation material in the cellular system. Then we observed these samples directly by using the cryo-transfer holder for transmission electron microscopy. Based on these techniques, we introduced the sample preparation system for the water structurization.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), HOKKAIDO UNIVERSITY, Principal investigator, Competitive research funding, 17340125
  • Creation and control of Fractal spatiotemporal hierarchical structure
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    2005 - 2007
    GOHARA Kazutoshi, UCHIDA Tsutomu, NAGAYAMA Masafumi, SHIOYA Hiroyuki
    views the system as being closed, I.e. an autonomous system. Another views the system as being open, I.e. a non-autonomous system. The former approach assumes the external environment to be composed of constituent subsystems. In relation to this approach, many researchers have been interested in chaotic phenomena. Consequently, for the autonomous system, chaos has been established as a prominent research area that might be key to developing an understanding of complex systems in nature. On the other hand, the investigation into non-autonomous systems is still in its initial phase, and no clear theoretical framework has yet been established. We believe that the main reason that little research has thus far been done in this area is the difficulty in examining the interaction between systems. Therefore, we must attempt to determine how we can describe this interaction from a dynamical systems point of view. A theory for continuous dynamical systems stochastically excited by temporal external inputs has been presented. The theory suggests that the dynamics of continuous-time recurrent neural networks (RNNs) is generally characterized by a set of continuous trajectories with a fractal-like structure in hyper-cylindrical phase space. We refer to this dynamics as the fractal transition. Three types of numerical experiments are discussed in order to investigate the learning process and noise effects in terms of the fractal transition. First, to analyze how an RNN learns desired input {output transformations, a simple example with a single state was examined in detail. A fractal structure similar to a Cantor set was clearly observed in the learning process. This finding sheds light on the learning of RNNs, I.e. it suggests that the learning is a process of adjusting the fractal dimension. Second, input noise effects on the fractal structure were investigated. The results show that small-scale hierarchical structures are broken by noise. Third, using a network with twenty states, we show that fractal transition is a universal characteristic of RNNs driven by switching inputs.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 17300069
  • Regulating cell behaviors by structurization of intra-/extra-cellular water
    Grants-in-Aid for Scientific Research(基盤研究(B))
    2005 - 2006
    Tsutomu UCHIDA, Kazutoshi GOHARA, Masafumi NAGAYAMA
    The project aimed to reveal the role of water playing on the signal transfer processes between neural cells or cardinal cells by water structurization. For this purpose, we studied the following two themes: 1) observations of the signal transfer in the cellular network and effects of temperature, pressure or composition of culturing circumstances including the clathrate forming components, and 2) development of the observation techniques on the structurized water between cells.In theme 1), we introduced the measurement system of electronic signals propagating in the cellular network. This system could control the culture conditions (temperature, pressure or compositions of vapor) independently. We observed these conditions effecting on the neural and cardinal cellular networks, especially low temperature and high pressure conditions which might lead the structurization of water, or form clathrate hydrates.In theme 2), we developed the observation system for structurized water via electron microscope. We first observed the replica samples of freeze-fractured surface on trehalose solution, which is known as one of the cryo-preservation material in the cellular system. Then we observed these samples directly by using the cryo-transfer holder for transmission electron microscopy. Based on these techniques, we introduced the sample preparation system for the water structurization.
    Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 北海道大学, Principal investigator, Competitive research funding, 17340125
  • The Resource Development for CH_4 Hydrates
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
    1995 - 1996
    MAE Shinji, UCHIDA Tutomu, GOUHARA Kazutoshi, HONDOU Takeo
    CO_2 hydrates and CH_4 hydrated were formed from gas (guest) and water (host) mixtures with controlling the formation rate to analyze Rarnan intensities of both guest and host molecules. The intensity ratio of both guest and host molecules between the gas-hydrate phase and the reference phase represented the density ratio of both molecules in teh gas hydrate. It was found that the guest-host molecular density ratio of gas hydrates formed under an non-equilibrium condition was different from that formed under equilibrium condition, and it fluctuated with formation conditions.
    The formation reaction rates and the dissociation reaction rates were studied at pure-water/pure-methane-gas reaction system, and the equations of both reaction were derived considering temperature and methane gas mole concentration. Also effects of the stirring rate on formation reaction were investigated. The formation reaction rate was in proportion to l/T and the dissociation reaction rate was inverse proportion to l/T.The activation energy of formation and dissociation reactions were determined as -140kJ/mol and 114kJ/mol respectively.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), HOKKAIDO UNIVERSITY, 07555322

Industrial Property Rights

Social Contribution Activities

  • 北海道札幌啓成高等学校スーパーサイエンスハイスクール運営指導委員会　　　　　　　　　　　　　　　
    Apr. 2013 - Present
    Advisor, Organizing member
    Others
    北海道札幌啓成高等学校スーパーサイエンスハイスクール
  • 北大総合博物館「卒論ポスター発表会」　　　　　　　　　　　　　　　
    2011 - Present
    Advisor
    Seminar
    北大総合博物館
  • メタンハイドレート開発促進事業「環境有識者会議」委員　　　　　　　　　　　　　　　
    24 Dec. 2009 - 31 Mar. 2019
    Advisor
    Research advise
    エンジニアリング協会

Media Coverage

  • 太古のアルゴン世界で初検出 グリーンランド深部の氷掘削 大気の歴史解明に期待 長岡技科大・本間准教授のチーム　　　　　　　　　　　　　　　
    08 Jan. 2022
    新潟日報
    [Paper]
  • 砂層型メタンハイドレートの基礎研究は、本当にもう充分？　　　　　　　　　　　　　　　
    2017
    青山千春、ワニ・プラス
    科学者の話ってなんて面白いんだろう
    [Others]
  • Studying H2O from Scientific Approach　　　　　　　　　　　　　　　
    Apr. 2015
    Hokkaido University Admission Center
    Research Frontiers: Featured Researchers
    [Pr]

syllabus

  • 生物物理工学特論, 2024年, 修士課程, 工学院
  • 生物物理工学特論, 2024年, 博士後期課程, 工学院
  • 一般教育演習(ﾌﾚｯｼｭﾏﾝｾﾐﾅｰ), 2024年, 学士課程, 全学教育
  • 応用物理学実験法, 2024年, 学士課程, 工学部
  • 応用物理学英文講読, 2024年, 学士課程, 工学部
  • 一般教育演習(ﾌﾚｯｼｭﾏﾝｾﾐﾅｰ), 2024年, 学士課程, 全学教育