研究活動情報

• DTI Histogram and Texture Features as Early Predictors of Post-Radiotherapy Cognitive Decline
  Jincheng Wang; Philip Kyeremeh Jnr Oppong; Maho Kitagawa; Hidefumi Aoyama; Shunsuke Onodera; Satoshi Terae; Khin Khin Tha
  Applied Sciences, 15, 12, 6794, 6794, MDPI AG, 2025年06月17日, ［査読有り］
  英語, 研究論文（学術雑誌）, Background: Radiotherapy for brain tumors can induce cognitive decline, yet most studies examine white matter (WM) damage six months post-treatment, overlooking early microstructural changes. This study investigated whether early WM changes, as measured by diffusion tensor imaging (DTI) histogram and texture features, can predict later cognitive deficits. Methods: Nineteen adults with brain metastases underwent DTI before and immediately after radiotherapy. Ten features—eight histogram-based and two texture-based—were extracted from normal-appearing WM of major DTI indices. Changes (Δ) in these features, if any, were analyzed via multiple linear regression, correlating them with cognitive performance at four months after therapy. Results: Out of 40 features, four exhibited significant post-radiotherapy changes. These were the mean (ADmean) and skewness (ADskewness) of axial diffusivity and the kurtosis of mean diffusivity (MDkurtosis) and radial diffusivity (RDkurtosis). Regression identified ΔADmean (β = −3.303 × 104, p = 0.002) as negatively and ΔADskewness (β = 4.642, p = 0.006) and ΔRDkurtosis (β = −1.505, p = 0.027) as positively associated with semantic fluency. Conclusions: Early WM microstructural disruptions—particularly axonal damage and heterogeneous injury—correlate with declines in semantic fluency. DTI histogram and texture features may be promising as early non-invasive biomarkers for cognitive risk following radiotherapy.
• Comparative Sensitivity of MRI Indices for Myelin Assessment in Spinal Cord Regions
  Philip Kyeremeh Jnr Oppong; Hiroyuki Hamaguchi; Maho Kitagawa; Nina Patzke; Kevin C. Wakeman; Khin Khin Tha
  Tomography, 11, 1, 8, 8, MDPI AG, 2025年01月14日, ［査読有り］
  英語, 研究論文（学術雑誌）, Background/Objectives: Although multiple magnetic resonance imaging (MRI) indices are known to be sensitive to the noninvasive assessment of myelin integrity, their relative sensitivities have not been directly compared. This study aimed to identify the most sensitive MRI index for characterizing myelin composition in the spinal cord’s gray matter (GM) and white matter (WM). Methods: MRI was performed on a deer’s ex vivo cervical spinal cord. Quantitative indices known to be sensitive to myelin, including the myelin water fraction (MWF), magnetization transfer ratio (MTR), the signal ratio between T1- and T2-weighted images (T1W/T2W), fractional anisotropy (FA), mean diffusivity (MD), electrical conductivity (σ), and T1, T2, and T1ρ relaxation times were calculated. Their mean values were compared using repeated measures analysis of variance (ANOVA) and post hoc Bonferroni tests or Friedman and post hoc Wilcoxon tests to identify differences across GM and WM columns possessing distinct myelin distributions, as revealed by histological analysis. Relationships among the indices were examined using Spearman’s rank-order correlation analysis. Corrected p < 0.05 was considered statistically significant. Results: All indices except σ differed significantly between GM and all WM columns. Two of the three WM columns had significantly different MWF, FA, MD, and T2, whereas one WM column had significantly different MTR, σ, T1, and T1ρ from the others. A significant moderate to very strong correlation was observed among most indices. Conclusions: The sensitivity of MRI indices in distinguishing spinal cord regions varied. A strategic combination of two or more indices may allow the accurate differentiation of spinal cord regions.
• Brain Temperature as an Indicator of Cognitive Function in Traumatic Brain Injury Patients
  Maho Kitagawa; Kagari Abiko; Sulaiman Sheriff; Andrew A. Maudsley; Xinnan Li; Daisuke Sawamura; Sinyeob Ahn; Khin Khin Tha
  Metabolites, 14, 1, 17, 17, MDPI AG, 2023年12月27日, ［査読有り］, ［筆頭著者］
  英語, 研究論文（学術雑誌）, Whether brain temperature noninvasively extracted by magnetic resonance imaging has a role in identifying brain changes in the later phases of mild to moderate traumatic brain injury (TBI) is not known. This prospective study aimed to evaluate if TBI patients in subacute and chronic phases had altered brain temperature measured by whole-brain magnetic resonance spectroscopic imaging (WB-MRSI) and if the measurable brain temperature had any relationship with cognitive function scores. WB-MRSI was performed on eight TBI patients and fifteen age- and sex-matched control subjects. Brain temperature (T) was extracted from the brain’s major metabolites and compared between the two groups. The T of the patients was tested for correlation with cognitive function test scores. The results showed significantly lower brain temperature in the TBI patients (p < 0.05). Brain temperature derived from N-acetylaspartate (TNAA) strongly correlated with the 2 s paced auditory serial addition test (PASAT-2s) score (p < 0.05). The observation of lower brain temperature in TBI patients may be due to decreased metabolic activity resulting from glucose and oxygen depletion. The correlation of brain temperature with PASAT-2s may imply that noninvasive brain temperature may become a noninvasive index reflecting cognitive performance.
• 脳腫瘍の診療におけるRadiomics，Radiogenomicsの活用
  タ キンキン; 北川 真歩; 工藤 與亮
  臨床放射線, 68, 9, 853, 859, 2023年09月10日
  英語
• Radiomics ―統合的解析で何が変わるか―
  北川 真歩; タ キンキン
  画像診断, 43, 8, 823, 832, 2023年06月25日, ［筆頭著者］
  日本語
• Quantitative Assessment of Intervertebral Disc Composition by MRI: Sensitivity to Diurnal Variation
  Hiroyuki Hamaguchi; Maho Kitagawa; Daiki Sakamoto; Ulrich Katscher; Hideki Sudo; Katsuhisa Yamada; Kohsuke Kudo; Khin Khin Tha
  Tomography, 9, 3, 1029, 1040, MDPI AG, 2023年05月16日, ［査読有り］
  英語, 研究論文（学術雑誌）, Whether diurnal variation exists in quantitative MRI indices such as the T1rho relaxation time (T1ρ) of the intervertebral disc (IVD) is yet to be explored. This prospective study aimed to evaluate the diurnal variation in T1ρ, apparent diffusion coefficient (ADC), and electrical conductivity (σ) of lumbar IVD and its relationship with other MRI or clinical indices. Lumbar spine MRI, including T1ρ imaging, diffusion-weighted imaging (DWI), and electric properties tomography (EPT), was conducted on 17 sedentary workers twice (morning and evening) on the same day. The T1ρ, ADC, and σ of IVD were compared between the time points. Their diurnal variation, if any, was tested for correlation with age, body mass index (BMI), IVD level, Pfirrmann grade, scan interval, and diurnal variation in IVD height index. The results showed a significant decrease in T1ρ and ADC and a significant increase in the σ of IVD in the evening. T1ρ variation had a weak correlation with age and scan interval, and ADC variation with scan interval. Diurnal variation exists for the T1ρ, ADC, and σ of lumbar IVD, which should be accounted for in image interpretation. This variation is thought to be due to diurnal variations in intradiscal water, proteoglycan, and sodium ion concentration.