Matoba Kotaro

Faculty of Medicine　Social Medicine　Social MedicineProfessor
Last Updated :2025/06/07

■Researcher basic information

Profile Information

  • 医師、医学博士、死体解剖資格、日本法医学会認定医

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Research Field

  • Life sciences, Forensic medicine

Educational Organization

■Research activity information

Papers

  • Postmortem contrast-enhanced computed tomography via direct large-vessel puncture
    Shogo Shimbashi, Akiko Takeuchi, Motoo Yoshimiya, Shigeki Jin, Kotaro Matoba, Hideki Hyodoh
    Legal Medicine, 69, 102448, 102448, Elsevier BV, Jul. 2024
    Scientific journal
  • Factors that hinder critical thinking and their resolution: Is active learning the key?
    Akiko Takeuchi, Shigeki Jin, Manabu Murakami, Kotaro Matoba
    Pakistan journal of medical sciences, 40, 6, 1313, 1314, Jul. 2024, [International Magazine]
    English, Scientific journal
  • The importance of early clinical exposure and interprofessional collaboration: Commonalities between Taiwan and Japan in the field of community medicine.
    Manabu Murakami, Akiko Takeuchi, Shigeki Jin, Kotaro Matoba
    Journal of the Chinese Medical Association : JCMA, 86, 11, 1037, 1038, 01 Nov. 2023, [International Magazine]
    English
  • Can the "Five Challenges" Overcome the Problem of "Reform Without Change" in Medical Education? Reexamining the "Hidden Curriculum".
    Manabu Murakami, Akiko Takeuchi, Shigeki Jin, Kotaro Matoba
    Acta medica portuguesa, 36, 9, 613, 614, 01 Sep. 2023, [International Magazine]
    English
  • 北海道大学病院における中毒検査診療体制の確立と地域連携の試み　　　　　　　　　　　　　　　
    方波見 謙一, 松本 悠, 早川 峰司, 神 繁樹, 的場 光太郎, 富田 明子
    中毒研究, 36, 2, 222, 222, (株)へるす出版, Jul. 2023
    Japanese
  • Objective Evaluation of Oral and Pharyngeal Areas in Autopsy Cases of Obstructive Sleep Apnea Syndrome via Postmortem CT.
    Akiko Takeuchi, Hideki Hyodoh, Shigeki Jin, Satoshi Tanaka, Manabu Murakami, Kazuyuki Minowa, Kotaro Matoba
    Current medical imaging, 28 Mar. 2023, [International Magazine]
    English, Scientific journal, BACKGROUND: Obstructive sleep apnea syndrome (OSAS) can cause sudden death during sleep. Previous findings have suggested that OSAS development is related to maxillofacial morphology. Evaluation of facial morphology can determine the risk of developing the disease, and establishing an objective method to assess the underlying etiology of OSAS-related death would be advantageous. OBJECTIVE: The objective of this study is to determine the key features of obstructive sleep apnea syndrome (OSAS) using postmortem oral and pharyngeal computed tomography (CT). METHODS: We retrospectively assessed autopsy cases of patients with (n=25) and without (n=25) OSAS-related death. We used oral and pharyngeal CT images to compare the oral and pharyngeal cavity volume (OPCV), oral and pharyngeal soft tissue volume (OPSV), oral and pharyngeal air space volume (OPAV), and OPAV to OPCV ratio (%air). Receiver operating curve (ROC) analysis was used to determine the accuracy of OSAS prediction. We assessed participants with body mass index (BMI) values within the normal range. RESULTS: Among the 50 subjects, we observed significant between-group differences in OPSV, OPAV, and % air, whereas there were significant between-group differences in OPSV and %air among 28 subjects with normal BMI values. Both comparisons suggested that OSAS-related death was associated with low %air and high OPSV values. CONCLUSION: The %air and OPSV are useful for assessing postmortem oropharyngeal CT images. OSAS-related sudden death is likely when %air and OPSV values are ≤20.1% and ≥127.2 ml, respectively. Among those with normal BMI values, % air and OPSV values of ≤22.8% and ≥111.5 ml, respectively, predict OSAS-related sudden death.
  • Objective evaluation of chest findings in infants by postmortem computed tomography.
    Shogo Shimbashi, Rina Hayata, Kotaro Matoba, Atsuko Saito, Tomoko Matoba, Akiko Takeuchi, Shigeki Jin, Hideki Hyodoh
    Legal medicine (Tokyo, Japan), 60, 102178, 102178, Feb. 2023, [International Magazine]
    English, Scientific journal, PURPOSE: The purpose of this study was to review the findings of computed tomography (CT) performed early postmortem on infants and to clarify the postmortem CT lung findings that occur in the absence of abnormal histopathological findings. MATERIALS AND METHODS: From July 2016 to March 2022, 72 infants were autopsied with postmortem CT (41 boys 31 girls, aged 0-36 (mean 8.2) months). Autopsy and postmortem CT lung findings were compared with the causes of death identified by the autopsies, namely sudden infant death syndrome (n = 37), acute circulatory system disease (18), drowning (7), asphyxia (5), and dehydration/undernutrition (5). RESULTS: The %aerated lung volume (-700 HU or less) ranged from 0 % to 33 % (mean 1.5 %, median 0 %), being <1 % in 61 cases (84.7 %) and >3 % in 3/5 (60 %) of the dehydration/undernutrition group. The dehydration/undernutrition group showed significant preservation of lung field air content compared with the other causes of death groups (p < 0.05). Receiver characteristic curve analysis showed a cut off value of 0.8 % and area under the curve of 0.88806. The drowning group had significantly greater pleural cavity fluid retention than the other causes of death groups (p < 0.05). No correlation was found between postmortem interval and pleural cavity fluid retention. However, resuscitation time and pleural cavity fluid retention were correlated. CONCLUSION: Evaluation of CT values on postmortem lung fields of infants usually reveals a marked decrease in air content. When air content exceeds 0.8% on infant postmortem CT, dehydration/undernutrition should be considered in the differential diagnosis.
  • How Undergraduates Perceive Stress Factors: An exploratory study.
    Manabu Murakami, Akiko Takeuchi, Shigeki Jin, Kotaro Matoba
    Pakistan journal of medical sciences, 39, 4, 1219, 1220, 2023, [International Magazine]
    English, Scientific journal
  • 直腸穿孔の原因特定に死後CT検査が有用であった一剖検例　　　　　　　　　　　　　　　
    的場 光太郎, 神 繁樹, 齋藤 厚子, 的場 智子, 竹内 明子, 赤川 有希, 早田 璃菜, 真橋 尚吾, 兵頭 秀樹
    法医学の実際と研究, 65, 119, 123, 法医学談話会, Nov. 2022
    Japanese
  • Students' perceptions on distance learning: Problems to be solved in the post COVID-19 era.
    Manabu Murakami, Manabu Murakami, Kotaro Matoba
    JPMA. The Journal of the Pakistan Medical Association, 72, 11, 2353, 2354, Nov. 2022, [International Magazine]
    English
  • 直腸穿孔の原因特定に死後CT検査が有用であった一剖検例　　　　　　　　　　　　　　　
    的場 光太郎, 神 繁樹, 齋藤 厚子, 的場 智子, 竹内 明子, 赤川 有希, 早田 璃菜, 真橋 尚吾, 兵頭 秀樹
    法医学の実際と研究, 65, 119, 123, 法医学談話会, Nov. 2022
    Japanese
  • Gluing blood into gel by electrostatic interaction using a water-soluble polymer as an embolic agent
    Zhiping Jin, Hailong Fan, Toshiya Osanai, Takayuki Nonoyama, Takayuki Kurokawa, Hideki Hyodoh, Kotaro Matoba, Akiko Takeuchi, Jian Ping Gong, Miki Fujimura
    Proceedings of the National Academy of Sciences, 119, 42, Proceedings of the National Academy of Sciences, 18 Oct. 2022
    Scientific journal, Liquid embolic agents are widely used for the endovascular embolization of vascular conditions. However, embolization based on phase transition is limited by the adhesion of the microcatheter to the embolic agent, use of an organic solvent, unintentional catheter retention, and other complications. By mimicking thrombus formation, a water-soluble polymer that rapidly glues blood into a gel without triggering coagulation was developed. The polymer, which consists of cationic and aromatic residues with adjacent sequences, shows electrostatic adhesion with negatively charged blood substances in a physiological environment, while common polycations cannot. Aqueous polymer solutions are injectable through clinical microcatheters and needles. The formed blood gel neither adhered to the catheter nor blocked the port. Postoperative computed tomography imaging showed that the polymer can block the rat femoral artery in vivo and remain at the injection site without nontarget embolization. This study provides an alternative for the development of waterborne embolic agents.
  • メトホルミン中毒による重篤な乳酸アシドーシスに対して血液浄化療法を行い救命に成功した一例　　　　　　　　　　　　　　　
    江原 慶介, 大城 あき子, 俵 敏弘, 岡本 博之, 清水 隆文, 大西 新介, 森下 由香, 奈良 理, 早川 峰司, 神 繁樹, 的場 光太郎
    日本救急医学会雑誌, 33, 10, 793, 793, (一社)日本救急医学会, Oct. 2022
    Japanese
  • 塩素化されたTyrosineのLC-MS/MS分析法の検討
    神 繁樹, 的場 光太郎, 赤川 有希, 早川 璃菜, 魚住 諒
    JSBMS Letters, 47, Suppl., 78, 78, (一社)日本医用マススペクトル学会, Aug. 2022
    Japanese
  • Nonverbal communication skills: New-era education needs of younger generation medical students
    Manabu Murakami, Shigeki Jin, Akiko Takeuchi, Kotaro Matoba
    Pakistan Journal of Medical Sciences, 38, 6, Pakistan Journal of Medical Sciences, 27 Jun. 2022
    Scientific journal, doi: https://doi.org/10.12669/pjms.38.6.6058 How to cite this:Murakami M, Jin S, Takeuchi A, Matoba K. Nonverbal communication skills: New-era education needs of younger generation medical students. Pak J Med Sci. 2022;38(6):---------. doi: https://doi.org/10.12669/pjms.38.6.6058 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • Objective skull fracture evaluation by using the postmortem 3D-CT skull fracture score in fatal falls
    Hideki Hyodoh, Akiko Takeuchi, Kotaro Matoba, Manabu Murakami, Tomoko Matoba, Atsuko Saito, Shigeki Jin
    Legal Medicine, 56, 102048, 102048, Elsevier BV, May 2022
    Scientific journal
  • The usefulness of measuring n-butyric acid concentration as a new indicator of blood decomposition in forensic autopsy.
    Kotaro Matoba, Manabu Murakami, Emi Fujita, Shigeki Jin, Ryosuke Ogasawara, Tomoko Matoba, Akiko Takeuchi, Sanae Haga, Michitaka Ozaki, Hideki Hyodoh
    Legal medicine (Tokyo, Japan), 57, 102071, 102071, 15 Apr. 2022, [International Magazine]
    English, Scientific journal, In forensic medicine, although various alcohols have been reported as indicators of decomposition in collected blood, no studies have examined short-chain fatty acids as indicators. In this study, the blood n-butyric acid concentration was quantified, and the association between n-butyric acid and decomposition was investigated to determine whether the detection of n-butyric acid could be a new indicator of decomposition. Among the forensic autopsies performed from 2016 to 2018 in our laboratory, the cases were divided into decomposed (n = 20) and non-decomposed (n = 20) groups based on macroscopic findings. Blood samples collected at the time of autopsy were derivatized with 3-nitrophenylhydrazine hydrochloride after solid-phase extraction. The n-butyric acid concentration was measured using liquid chromatography-tandem mass spectrometry. In addition, ethanol and n-propanol were measured using a gas chromatography-flame ionization detector. There was a significant difference (p < 0.01) in the concentrations of n-butyric acid between the decomposed and non-decomposed groups (0.343 ± 0.259 [0.030-0.973] and 0.003 ± 0.002 [0.001-0.007] mg/mL, respectively). In the decomposed group, n-butyric acid was detected at high concentrations, even in cases where n-propanol was low. These results suggest that n-butyric acid is more likely to be an indicator of blood decomposition than n-propanol.
  • Skills Required of Geriatricians: Why Medical Students Do Not Select Geriatrics as Their Career
    Manabu Murakami, Shigeki Jin, Akiko Takeuchi, Kotaro Matoba
    Acta Médica Portuguesa, 35, 3, 231, 231, Ordem dos Medicos, 02 Mar. 2022
    Scientific journal, N/a.
  • 3-クロロチロシンの検出によって塩素ガス中毒死を診断した一剖検例　　　　　　　　　　　　　　　
    的場 光太郎, 神 繁樹, 齋藤 厚子, 的場 智子, 竹内 明子, 赤川 有希, 早田 璃菜, 兵頭 秀樹
    法医学の実際と研究, 64, 25, 29, 法医学談話会, Nov. 2021
    Japanese
  • Poly(ADP-ribose) polymerase (PARP) is critically involved in liver ischemia/reperfusion-injury
    S. Haga, A. Kanno, N. Morita, S. Jin, K. Matoba, T. Ozawa, M. Ozaki
    The Journal of Surgical Research, 270, 124, 138, Oct. 2021, [Peer-reviewed]
    English, Scientific journal
  • Generation gaps in medical education: An exploratory qualitative study.
    Manabu Murakami, Kotaro Matoba, Hideki Hyodoh, Makoto Takahashi
    JPMA. The Journal of the Pakistan Medical Association, 71, 5, 1476, 1478, May 2021, [International Magazine]
    English, Scientific journal, This qualitative study aimed to explore medical students' experience of generation gap in their interactions with senior teachers (aged >55) in Japan. Focus group interviews were conducted with 28 medical students (20 to 30 years, mean age 22 ±2 years, classified as millennials, with only one year of studies since starting specialised courses for medicine. The participants were interviewed in groups of four, with each interview lasting 60 minutes. Topics covered included generation gap experienced in daily life and during their studies, and work-life balance issues. The discussions were recorded and transcribed, and content analysis was applied. Four specific influential generation-gap categories were identified - distinctive sociocultural backgrounds, more recent educational media tools and faster information dissemination speed, new-era values, and challenges in communication - that were consistent with findings from previous studies. More senior personnel involved in medical education need to consider these categories to enhance effectiveness of teaching.
  • Problems in implementing interprofessional education in rural areas: an exploratory study.
    Kotaro Matoba, Hideki Hyodoh, Manabu Murakami
    Rural and remote health, 21, 2, 6726, 6726, Apr. 2021, [International Magazine]
    English, Scientific journal
  • Evaluation of oral air space volume in obstructive sleep apnea syndrome using clinical and postmortem CT imaging.
    Akiko Takeuchi, Hideki Hyodoh, Kotaro Matoba, Manabu Murakami, Kohsuke Kudo, Kazuyuki Minowa
    Oral radiology, 38, 1, 29, 36, 20 Mar. 2021, [Domestic magazines]
    English, Scientific journal, OBJECTIVES: Obstructive sleep apnea syndrome (OSAS) induces upper airway occlusion and may cause sudden death during sleep. This study sought to clarify the relationship between oral air space volume and OSAS onset, which is influenced by multiple factors, such as jawbone, dentition morphology, and oral soft-tissue volume. METHODS: (1) 50 subjects from deceased cases were divided into two groups: OSAS (25 subjects) and controls (25 subjects). (2) 28 subjects from clinical cases were divided into two groups: OSAS (9 subjects) and controls (19 subjects). In all cases, the Computed Tomography (CT) images of the facial region were obtained, and four parameters of oral area volume were analyzed in deceased and clinical cases, and comparisons and analyses were performed between OSAS and control cases. In addition, the efficiency of measurement of these parameters was evaluated using Receiver Operating Characteristic (ROC) curves in OSAS. RESULTS: (1) In deceased cases, oral soft-tissue volume (OSV), oral air-space volume (OAV), and the ratio of OAV to OSV (%air) showed a significant correlation. (2) In clinical cases, OAV and %air showed a significant correlation. In both postmortem and clinical images, a small %air value indicates a high risk of developing OSAS and a high probability of OSAS-related sudden death. CONCLUSIONS: It was shown that the %air is an index to evaluate OSAS by CT imaging of the oral region. OSAS may be indicated when the %air value is ≦ 16.0% in deceased cases and ≦ 6.6% in clinical cases.
  • Do 'The Four Principles' Apply to the Improvement of Short-Term Clinical Electives?
    Kotaro Matoba, Manabu Murakami, Hideki Hyodoh
    Acta medica portuguesa, 34, 3, 238, 238, 01 Mar. 2021, [International Magazine]
    English
  • Educational support required by new forensic pathology trainees: An exploratory qualitative study.
    Manabu Murakami, Hideki Hyodoh, Kotaro Matoba
    The National medical journal of India, 34, 2, 124, 124, 2021, [International Magazine]
    English
  • Enhancing students' motivations through early exposure in actual settings is key.
    Manabu Murakami, Kotaro Matoba, Hideki Hyodoh
    The National medical journal of India, 34, 3, 188, 188, 2021, [International Magazine]
    English, Scientific journal
  • クロバエ科の蛆が薬物検査に有用であった一剖検例　　　　　　　　　　　　　　　
    的場 光太郎, 奥谷 菜穂子, 神 繁樹, 齋藤 厚子, 的場 智子, 竹内 明子, 兵頭 秀樹
    法医学の実際と研究, 63, 103, 106, 法医学談話会, Nov. 2020
    Japanese
  • 予期せぬ死に直面した遺族への対応 新型コロナウイルス感染による遺族に焦点を当てて　　　　　　　　　　　　　　　
    山田 典子, 兵頭 秀樹, 的場 光太郎
    日本災害看護学会誌, 22, 1, 102, 102, (一社)日本災害看護学会編集委員会, Sep. 2020
    Japanese
  • 血中チオ硫酸塩濃度の保存による変化について　　　　　　　　　　　　　　　
    神 繁樹, 的場 光太郎, 的場 智子, 兵頭 秀樹
    日本法医学雑誌, 74, 1, 73, 73, (NPO)日本法医学会, Aug. 2020
    Japanese
  • クロバエ科の蛆が薬物検査に有用であった一剖検例　　　　　　　　　　　　　　　
    的場 光太郎, 奥谷 菜穂子, 神 繁樹, 兵頭 秀樹
    日本法医学雑誌, 74, 1, 90, 90, (NPO)日本法医学会, Aug. 2020
    Japanese
  • 高コルチゾール血症を呈したFamilial Dysalbuminemic Hyperthyroxinemiaの一例
    千葉 幸輝, 亀田 啓, 野本 博司, 曹 圭龍, 中村 昭伸, 神 繁樹, 的場 光太郎, 三好 秀明, 渥美 達也
    日本内分泌学会雑誌, 96, 1, 366, 366, (一社)日本内分泌学会, Aug. 2020
    Japanese
  • Sample preparation method with ultrafiltration for whole blood thiosulfate measurement.
    Shigeki Jin, Manabu Murakami, Kotaro Matoba, Tomoko Matoba, Sanae Haga, Michitaka Ozaki, Akiko Takeuchi, Hideki Hyodoh
    Legal medicine (Tokyo, Japan), 47, 101765, 101765, 23 Jul. 2020, [Peer-reviewed], [International Magazine]
    English, Scientific journal, Quantitative analysis of thiosulfate is useful for diagnosing hydrogen sulfide poisoning. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) enables more rapid and sensitive measurements than previous methodologies. As simple measurements of blood thiosulfate concentration are affected by the blood matrix, blood is used as the solvent to prepare the standard solution for calibration curve generation. Thus, a large amount of blood devoid of thiosulfate is required. We developed a preparation method by incorporating an ultrafiltration step to overcome this limitation and generate a calibration curve using a standard solution prepared with pure water. We used this improved method to investigate the stability of thiosulfate in refrigerated samples. To compare the effects of refrigeration, blood samples were prepared using the following two methods: one sample was treated with a 50-kDa exclusion ultrafiltration membrane and the other was not treated. The samples were stored at 4 °C, and then measured at 0, 3, 6, 24, 48, and 96 h. The incorporation of the ultrafiltration step in the measurement procedure enabled the quantification of thiosulfate, by plotting a calibration curve using a standard of pure water; it did not require a blood standard. Additionally, the reduction in whole blood thiosulfate concentration was within 10% during 2 days of refrigeration. Thus, the need for a large amount of blood to prepare the standard solution was resolved by the ultrafiltration step in test sample preparation. This method is useful to measure thiosulfate concentration and is not hindered by sample refrigeration for a few days.
  • 肝胆膵と医療安全(第5回) 医療事故調査と病理解剖
    田中 敏, 的場 光太郎, 原田 太以佑, 兵頭 秀樹, 南須原 康行, 田中 伸哉
    肝胆膵, 81, 1, 137, 142, (株)アークメディア, Jul. 2020
    Japanese
  • Post-mortem computed tomography in sudden death by asthma.
    Casey Smith, Kotaro Matoba, Hideki Hyodoh, Manabu Murakami, Atsuko Saito, Tomoko Matoba, Nahoko Okuya, Shigeki Jin
    Legal medicine (Tokyo, Japan), 44, 101694, 101694, 19 Mar. 2020, [Peer-reviewed], [International Magazine]
    English, Ground glass attenuation (GGA) of the lungs is a common finding of post-mortem computed tomography (PMCT) that is associated with pulmonary congestion and edema due to cardiac failure during the agonal period, or due to post-mortem hypostasis. However, hypo-attenuation of the lung is an atypical finding of PMCT, and is usually a consequence of hypovolemic states before death or postmortem body posture after death. Previous studies have shown a few differential diagnoses, such as hypothermia, massive hemorrhage, asphyxiation by hanging, and dehydration, for hypo-attenuation of the lung. This report presents the case of a woman who died suddenly because of an asthma attack. Our PMCT analysis demonstrated hypoattenuation of the lung in this case. We suggest fatal asthma as a differential diagnosis for the appearance of hypo-attenuation of lungs on PMCT.
  • 【2020年のRadiology 今年1年を診断する!】オートプシー・イメージング 2020年のオートプシー・イメージング(死後画像)はこうなる　　　　　　　　　　　　　　　
    兵頭 秀樹, 的場 光太郎
    Rad Fan, 18, 4, 72, 75, (株)メディカルアイ, Mar. 2020
    Japanese
  • The infusion effect in postmortem lung CT
    Hideki Hyodoh, Kotaro Matoba, Manabu Murakami, Atsuko Saito, Nahoko Okuya, Tomoko Matoba, Shigeki Jin
    Forensic Imaging, 20, 200367, 200367, Elsevier BV, Mar. 2020
    Scientific journal
  • Evaluation of Fruit Anthocyanin Composition by LC/MS in Interspecific Hybrids Between Haskap (Lonicera caerulea subsp. edulis (Turcz. ex. Herder) Hultén) and Miyama-uguisukagura (Lonicera gracilipes Miq.)
    Ryohei Fujita, Shigeki Jin, Takahiro Hayasaka, Kotaro Matoba, Yoichiro Hoshino
    The Horticulture Journal, 89, 4, 343, 350, Japanese Society for Horticultural Science, 2020, [Peer-reviewed]
    English, Scientific journal
  • 凍死における肝細胞アポトーシス誘導の法医病理学的検索　　　　　　　　　　　　　　　
    大谷 静治, 的場 光太郎, 兵頭 秀樹
    法医学の実際と研究, 62, 214, 214, 法医学談話会, Nov. 2019
    Japanese
  • 溺死事例の死戦期に起きた食物誤嚥が解剖所見や検査結果に与える影響に関する検討　　　　　　　　　　　　　　　
    的場 光太郎, 兵頭 秀樹, 齋藤 厚子, 的場 智子, 奥谷 菜穂子, 竹内 明子, 邵 旻蓉, 神 繁樹
    法医学の実際と研究, 62, 15, 19, 法医学談話会, Nov. 2019
    Japanese
  • 剖検時採血で劇症1型糖尿病が判明した子宮内胎児死亡、母体死亡の症例　　　　　　　　　　　　　　　
    田中 敏, 的場 光太郎, 兵頭 秀樹, 菊池 穏香, 南須原 康行, 田中 伸哉
    日本病理学会会誌, 108, 2, 91, 91, (一社)日本病理学会, Sep. 2019
    Japanese
  • 剖検時採血で劇症1型糖尿病が判明した子宮内胎児死亡、母体死亡の症例　　　　　　　　　　　　　　　
    田中 敏, 的場 光太郎, 兵頭 秀樹, 菊池 穏香, 南須原 康行, 田中 伸哉
    日本病理学会会誌, 108, 2, 132, 132, (一社)日本病理学会, Sep. 2019
    Japanese
  • 死後造影CTに関する検討(Postmortem enhanced CT(PMeCT)　　　　　　　　　　　　　　　
    兵頭 秀樹, 的場 光太郎, 神 繁樹
    日本法医学雑誌, 73, 1, 73, 73, (NPO)日本法医学会, May 2019
    Japanese
  • 死後変化による腐敗が血液中のチオ硫酸濃度に与える影響について　　　　　　　　　　　　　　　
    的場 光太郎, 神 繁樹, 兵頭 秀樹
    日本法医学雑誌, 73, 1, 85, 85, (NPO)日本法医学会, May 2019
    Japanese
  • チオ硫酸塩測定における血液サンプルの前処理の検討　　　　　　　　　　　　　　　
    神 繁樹, 的場 光太郎, 兵頭 秀樹
    日本法医学雑誌, 73, 1, 86, 86, (NPO)日本法医学会, May 2019
    Japanese
  • 閉塞性睡眠時無呼吸症候群(OSAS)における口腔領域の画像評価に関する研究　　　　　　　　　　　　　　　
    竹内 明子, 兵頭 秀樹, 的場 光太郎, 箕輪 和行
    北海道歯学雑誌, 39, 2, 159, 159, 北海道歯学会, Mar. 2019
    Japanese
  • Lung weight estimation with postmortem CT in forensic cases.
    Kotaro Matoba, Hideki Hyodoh, Lisa Ishida, Manabu Murakami, Tomoko Matoba, Atsuko Saito, Nahoko Okuya, Sahar Almansoori, Emi Fujita, Mayumi Yamase, Minyo Shao, Shigeki Jin
    Legal medicine (Tokyo, Japan), 35, 61, 65, Nov. 2018, [Peer-reviewed], [International Magazine]
    English, Scientific journal, Postmortem computed tomography (CT) is a minimally invasive technique to examine internal organs before a forensic autopsy. The purpose of our study was to estimate lung weight in a forensic setting in cases of various lung states, including fluid accumulation (congestion, edema, hypostasis, and inflammation etc.) using postmortem CT. From January 2016 to July 2018, 111 deceased bodies (62 males and 59 females, aged from 18 to 95 (average 59.6) years) were examined by CT before autopsy. Both lungs of the 111 deceased were analyzed separately, making it a total of 222 samples. We extracted lung fields from CT images manually after semi-automatic detection using an image workstation. The total lung volume and 6 categories of lung volume divided according to their CT density were measured. Multiple regression analysis was performed with lung weight in autopsy as the response variable, while the 6 categories were labelled as explanatory variables. The relation between lung weight in autopsy and lung weight estimated using postmortem CT showed a high Pearson's correlation coefficient (R2 = 0.9106). Using postmortem CT, the lung weight can be estimated in forensic settings.
  • 心筋トロポニンT濃度の死後変化の影響に関する検討　　　　　　　　　　　　　　　
    的場 光太郎, 兵頭 秀樹, 齋藤 厚子, 石田 理沙, 神 繁樹
    法医学の実際と研究, 61, 151, 154, 法医学談話会, Nov. 2018
    Japanese
  • Lethal complication in Pott's Puffy tumor: A case report
    Hideki Hyodoh, Kotaro Matoba, Manabu Murakami, Atsuko Saito, Nahoko Okuya, Tomoko Matoba
    Journal of Forensic Radiology and Imaging, 14, 12, 15, Elsevier Ltd, 01 Sep. 2018
    English, Scientific journal
  • Estimating normal lung weight measurement using postmortem CT in forensic cases
    Kotaro Matoba, Hideki Hyodoh, Manabu Murakami, Atsuko Saito, Tomoko Matoba, Lisa Ishida, Emi Fujita, Mayumi Yamase, Shigeki Jin
    LEGAL MEDICINE, 29, 77, 81, Nov. 2017, [Peer-reviewed]
    English, Scientific journal
  • Freezing preparation for macroscopic forensic investigation in putrefied brain
    Kotaro Matoba, Hideki Hyodoh, Manabu Murakami, Tomoko Matoba, Atsuko Saito, Fei Feng, Shigeki Jin
    LEGAL MEDICINE, 26, 6, 10, May 2017, [Peer-reviewed]
    English, Scientific journal
  • Diagnosis of drowning: Electrolytes and total protein in sphenoid sinus liquid
    Akira Hayakawa, Koichi Terazawa, Kotaro Matoba, Kie Horioka, Tatsushige Fukunaga
    FORENSIC SCIENCE INTERNATIONAL, 273, 102, 105, Apr. 2017, [Peer-reviewed]
    English, Scientific journal
  • Experimental evaluation of freezing preparation for the macroscopic inspection in putrefied brain
    Hideki Hyodoh, Kotaro Matoba, Manabu Murakami, Tomoko Matoba, Atsuko Saito, Fei Feng, Shigeki Jin
    LEGAL MEDICINE, 24, 19, 23, Jan. 2017, [Peer-reviewed]
    English, Scientific journal
  • Liquid chromatography-tandem mass spectrometry method for the determination of thiosulfate in human blood and urine as an indicator of hydrogen sulfide poisoning
    Chikatoshi Maseda, Akira Hayakawa, Katsuhiro Okuda, Masaru Asari, Hiroki Tanaka, Hiromi Yamada, Shigeki Jin, Kie Horioka, Kotaro Matoba, Hiroshi Shiono, Kazuo Matsubara, Keiko Shimizu
    LEGAL MEDICINE, 24, 67, 74, Jan. 2017, [Peer-reviewed]
    English, Scientific journal
  • 【シーン別画像診断のいま-社会的要求への対応と課題 Scene Vol.10 オートプシー・イメージング(Ai) 第六弾 迫りくる多死社会とAiの役割 社会インフラとしての現状と今後の展開】地域医療におけるオートプシー・イメージング(Ai)の実際 北海道におけるAiの現状と死因究明教育研究センターの役割
    兵頭 秀樹, 的場 光太郎
    INNERVISION, 32, 1, 34, 36, (株)インナービジョン, Dec. 2016
    Japanese
  • Stature estimation from anatomical landmarks in femur using postmortem CT
    Miho Baba, Hideki Hyodoh, Shunichiro Okazaki, Junya Shimizu, Keisuke Mizuo, Masumi Rokukawa, Satoshi Watanabe, Kotaro Matoba, Hiromasa Inoue
    Journal of Forensic Radiology and Imaging, 7, 28, 32, 01 Dec. 2016, [Peer-reviewed]
    English, Scientific journal
  • Development for the measurement of serum thiosulfate using LC-MS/MS in forensic diagnosis of H2S poisoning
    Shigeki Jin, Hideki Hyodoh, Kotaro Matoba, Fei Feng, Akira Hayakawa, Katsuhiro Okuda, Keiko Shimizu, Sanae Haga, Michitaka Ozaki, Koichi Terazawa
    LEGAL MEDICINE, 22, 18, 22, Sep. 2016, [Peer-reviewed]
    English, Scientific journal
  • Time-related change evaluation of the cerebrospinal fluid using postmortem CT
    Kohei Morikawa, Hideki Hyodoh, Kotaro Matoba, Keisuke Mizuo, Shunichiro Okazaki, Satoshi Watanabe
    LEGAL MEDICINE, 22, 30, 35, Sep. 2016, [Peer-reviewed]
    English, Scientific journal
  • Appropriate blood sampling sites for measuring Tg concentrations for forensic diagnosis
    Akira Hayakawa, Kotaro Matoba, Kie Horioka, Manabu Murakami, Koichi Terazawa
    LEGAL MEDICINE, 17, 1, 65, 69, Jan. 2015, [Peer-reviewed]
    English, Scientific journal
  • Unreliability of the use of thyroglobulin concentration in postmortem blood samples in forensic diagnosis
    Akira Hayakawa, Kotaro Matoba, Kie Horioka, Manabu Murakami, Koichi Terazawa
    LEGAL MEDICINE, 16, 3, 164, 167, May 2014, [Peer-reviewed]
    English, Scientific journal
  • What younger forensic pathologists need for their training: Valuable comments from our interviews
    Manabu Murakami, Kotaro Matoba, Koichi Terazawa
    LEGAL MEDICINE, 15, 1, 55, 55, Jan. 2013, [Peer-reviewed]
    English
  • Raising future forensic pathologists (first report): results of a preliminary questionnaire survey.
    Murakami M, Matoba K, Terazawa K
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 87, 4-5, 153, 157, Aug. 2012, [Peer-reviewed]
    English
  • Raising future forensic pathologists (second report): results of a preliminary interview survey.
    Murakami M, Matoba K, Hayakawa A, Terazawa K
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 87, 4-5, 159, 163, Aug. 2012, [Peer-reviewed], [Domestic magazines]
    English, Scientific journal, Fostering the specialists of forensic pathology has become a worldwide problem. In Japan, factors such as government budget cuts, the introduction of initial postgraduate clinical training system, as well as national policy on increasing autopsy rates, may deter young graduates from entering this specialty. The aim of this study was to look for clues to promote the training of young forensic pathologists. We selected and interviewed five forensic pathologists, with each interview lasting approximately 60 minutes, and picked up common views among them. The interviews topic, based on a prior survey, was: "What do you believe forensic pathologists require to promote the training of their successors." We selected common views on the three themes listed below; 1) standardization of minimum requirements to be independent forensic pathologists, 2) balancing forensic pathologists' time among autopsy practice, research, and education, and 3) preparing positions for younger forensic pathologists. These opinions were the same as those of previous studies conducted overseas and must be discussed at academic conferences in the future, where both junior and senior forensic pathologists participate.
  • Application of electrolyte analysis of pleural effusion to diagnosis of drowning
    Kotaro Matoba, Manabu Murakami, Akira Hayakawa, Koichi Terazawa
    LEGAL MEDICINE, 14, 3, 134, 139, May 2012, [Peer-reviewed]
    English, Scientific journal
  • 頸部より上方に溢血点を認めるうつ伏せ状態で発見された焼死体の1剖検例 溢血点の発生機序および死後の血液就下の影響の検討　　　　　　　　　　　　　　　
    的場 光太郎, 木内 隆之, 寺沢 浩一
    法医学の実際と研究, 52, 17, 23, 法医学談話会, Nov. 2009
    Japanese
  • Unusual injuries on the right hand and forearm caused by unidentified wild animals
    Takayuki Kiuchi, Kotaro Matoba, Koichi Terazawa
    Legal Medicine, 10, 6, 301, 305, Nov. 2008, [Peer-reviewed]
    English, Scientific journal
  • [Estimation of the time of death of decomposed or skeletonized bodies found outdoors in cold season in Sapporo city, located in the northern district of Japan].
    Matoba K, Terazawa K
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 83, 4, 275, 279, Jul. 2008, [Peer-reviewed]
    Japanese
  • Estimation of the time of death of decomposed or skeletonized bodies found outdoors in cold season in Sapporo city, located in the northern district of Japan
    Kotaro Matoba, Koichi Terazawa
    Legal Medicine, 10, 2, 78, 82, Mar. 2008, [Peer-reviewed]
    English, Scientific journal
  • An autopsy case of intraoperative death due to pulmonary fat embolism - possibly caused by release of tourniquet after multiple muscle-release and tenotomy of the bilateral lower limbs
    Satoshi Watanabe, Koichi Terazawa, Kotaro Matoba, Naoya Yamada
    FORENSIC SCIENCE INTERNATIONAL, 171, 1, 73, 77, Aug. 2007, [Peer-reviewed]
    English, Scientific journal
  • Age estimation from quantitative evaluation of atherosclerosis of abdominal aorta in Japanese.
    Watanabe S, Terazawa K, Matoba K
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 82, 2, 91, 98, Mar. 2007, [Peer-reviewed]
    English
  • [Problems in applying a rapid assay kit for cardiac troponin T to medico-legal blood samples].
    Matoba K, Terazawa K, Watanabe S, Yamada N, Ueda M
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 81, 5, 359, 363, Sep. 2006, [Peer-reviewed]
    Japanese
  • [Estimation of time of death by the use of the overwintering of flies].
    Terazawa K, Matoba K, Watanabe N, Watanabe S, Yamada N
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 81, 4, 265, 269, Jul. 2006, [Peer-reviewed]
    Japanese

Other Activities and Achievements

Research Themes

  • 歯科的身元確認を支援する包括的歯科材料データベースの構築-災害時応用を目指して　　　　　　　　　　　　　　　
    科学研究費助成事業
    Apr. 2024 - Mar. 2026
    竹内明子, 的場光太郎, 神 茂樹, 箕輪和行
    基盤研究(C), 24K13384
  • Development of a new method of drug toxicology for severe decomposed cases based on forensic entomotoxicology
    Grants-in-Aid for Scientific Research
    01 Apr. 2022 - 31 Mar. 2025
    的場 光太郎, 神 繁樹
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 22K10599
  • 児童虐待に対応するための小児死後CTの至適条件、死後変化、診断の標準化の検討
    科学研究費助成事業
    01 Apr. 2020 - 31 Mar. 2025
    高橋 直也, 的場 光太郎, 成田 啓廣, 高塚 尚和, 舟山 一寿, 石川 浩志, 堀井 陽祐
    １）小児死後CTの至適条件の検討について。新生児の体格とX線吸収値を模した新生児ファントムを新潟大学医学部法医学教室の16列DualエネルギーMDCTで撮像して得られたCT画像の画質を検討した。複数の管電流を用いて得られた頭部CT画像に、計算ソフトウェアを用いて作成した仮想模擬病変を挿入し、病変の検出能を検討した。模擬病変の直径が7.5 mmの場合，240mAsが最適線量であった．直径5 mmの病変でコントラスト差が小さい場合500 mAsでも検出が困難であった．この結果は、第79回日本放射線技術学会総会学術大会で発表した。同様に5歳幼児の体格とX線吸収値を模した幼児ファントムを複数の管電流を用いて撮像した頭部CT画像に、仮想模擬病変を挿入して、病変の検出能を検討した。管電流が高い場合、模擬病変の検出率は向上したが、直径8 mm以下の模擬病変で4HUのコントラストの差の場合，設定可能な最大の線量である400 mAsでも検出できなかった．コントラストの差が小さい場合、高線量でも検出が難しいことが明らかとなった。この結果は、第21回オートプシー・イメージング学会学術総会にて発表した。
    ２）小児死後CTにおける死後変化について。新潟大学と北海道大学で解剖を行った小児症例において、病院で死亡直後に撮影されたCTと死後数日間の冷蔵保存後に撮影されたCTの、肺の含気量を比較検討した。成人例でも同様の検討を行い、成人と小児における死後変化の差異を明らかとした。小児、成人とも死後冷蔵保存していたにも関わらず死後の時間経過で肺の含気領域は減少し、特に乳幼児でその傾向が強かった。肺の含気体積の減少は、小児の方が成人よりも減少率が大きかった。この結果は、第21回オートプシー・イメージング学会学術総会にて発表した。
    日本学術振興会, 基盤研究(B), 新潟大学, 23K20177
  • 児童虐待に対応するための小児死後CTの至適条件、死後変化、診断の標準化の検討
    科学研究費助成事業
    01 Apr. 2020 - 31 Mar. 2025
    高橋 直也, 的場 光太郎, 成田 啓廣, 高塚 尚和, 舟山 一寿, 石川 浩志, 堀井 陽祐
    １）小児死後CTの至適条件の検討について。新生児の体格とX線吸収値を模した新生児ファントムを新潟大学医学部法医学教室の16列DualエネルギーMDCTで撮像して得られたCT画像の画質を検討した。CTでは管電流をあげると良好な画像が得られる。被曝の影響を考慮する必要がない遺体の場合、臨床で用いられない高い管電流を使用することが可能であるが、必要以上の管電流を使用すると、機器の負担が増える。複数の管電流を用いて得られた頭部CT画像に、計算ソフトウェアを用いて作成した仮想模擬病変を挿入し、病変の検出能を検討した。経験豊富な2名の放射線科医が、仮想模擬病変が挿入されたCT画像を観察し、この病変が検出できるかどうかを判断し、微細病変の検出に必要な最低限の撮像条件を明らかにした。今後は、小児ファントムを用いて、同様の撮像実験、病変検出能の検討を行い、体格の異なる小児におけるCTの至適条件を検討する予定である。
    ２）小児死後CTの画像収集について。２－１）2021年度に新潟大学法医学教室で死後CT検査が行われた小児は４例であった。このうち２例で解剖が行われ、体内の状態と死因についての結果が得られた。解剖が行われた症例については死後CTの画像所見と解剖における実際の所見を比較検討が可能であった。今後は、症例を蓄積し、死後画像所見における死因究明、死後変化について、さらなる検討を行う。２－２）新潟大学放射線医学教室の協力のもと、関連病院において小児死後CT画像の症例の提供を依頼した。各病院の倫理審査委員会で審議を行っていただき、症例提供の手続きを行った。関連病院から、2020年4月から2025年3月までの症例を提供していただき、死後CT所見における死後変化や死因究明の検討を行う。
    日本学術振興会, 基盤研究(B), 新潟大学, 20H01654
  • 遺族ケアのニーズに対するフォレンジック看護の役割と看護記録システムの検討
    科学研究費助成事業
    01 Apr. 2020 - 31 Mar. 2023
    山田 典子, 兵頭 秀樹, 的場 光太郎, 斎藤 和樹
    災害遺族支援は、急性期の情報提供が主であり、継続的な観点からの支援について十分な知見が全国に周知されていない現状が散見される。「被災者遺族支援の調査」より遺族のニーズを明らかにする計画であったが、COVID-19の変異型の感染拡大が原因で調査が難しい現状がある。その一方で、東日本大震災より11年を経て、遺族が様々な媒体を通じて語りはじめている。遺族の反応は多様で、精神的なケアのニーズは一般化が難しいことを実感している。しかし、DMORTの実践者から得られた情報をもとに、自然災害等で不慮の死を遂げた遺族へのフォレンジック看護支援について検討しつつ、フォレンジック看護支援が実践できる人材育成に必要な知識や技術とは何か、共同研究者である法医学者らが定期的に開催している死後画像診断セミナーに参加し、災害によって亡くなった方と遺族の方双方へ、求められるケアを提供できる人材育成に必要な知識や技術に関する内容の検討を重ねている。
    2021年度は、COVID-19 の感染症も災害と捉え、文献をもとに遺族の求める死別のケアについて論考をまとめた。また、東日本大震災の被災地域に居住する方の「自然災害における遺族のグリーフ」と「自死遺族が背負っているグリーフ」の類似性や差異性について、先行研究をもとに分析を行った。その結果、自死遺族が背負うスティグマや自責の念の深さは、災害による「予期しない死」が原因で遺族になった者の背負う自責感と似て異なるものであった。これらの一連の文献検討より、一般的に他者が触れることが難しい「異状死」を背景とする遺族体験には、従来のグリーフケアだけでは不十分であることが推察された。そこでフォレンジックな観察眼を糸口に、従来の遺体発見と管理および遺体安置面におけるケアの不足に対して、看護の視点で貢献できる要素を検討中である。
    日本学術振興会, 基盤研究(C), 日本赤十字秋田看護大学, 20K10643
  • 全身主要血管壁内における歯周病原性菌の存在分布ー脳血管障害による死亡例をもとに
    科学研究費助成事業
    01 Apr. 2020 - 31 Mar. 2023
    竹内 明子, 的場 光太郎, 箕輪 和行, 兵頭 秀樹, 亀田 浩之, 長谷部 晃
    研究期間２年目では、ご遺体（法医解剖体）における死後CT画像取得時に、全身大血管（大脳動脈、頚動脈、胸部大動脈、腹部大動脈）における壁肥厚やプラークによる血管狭窄に対する画像的検索を進めており、これらの症例数は累計で18件となりました。
    検体採取を行ったそれぞれの症例において画像的検索と法医解剖所見を比較することで、歯周病細菌の存在分布検証に用いる検体（主要血管壁）の採取部位をそれぞれ決定しました。また、採取した血管壁を用いて、凍結切片の作成により、病理学的検索の可能性を模索し、免疫染色による歯周病菌の同定（存在分布の確認）についても追加の検討を行っています。
    予備実験において、死後CT画像にて血管壁に石灰化が見られる場合、DNA採取が困難である場合があり、血管壁の石灰化の度合いに対して、死後CT画像上でのスコア化を追加検討しています。
    また、法医解剖体の口腔内所見採取時に、歯周病進行状況、残存歯数、歯科治療痕等のデータ収集をさらに進めています。検体数の増加により、前年度に取得した歯周ポケット検査による歯周病進行度のスコアに変更が生じたため、再度検討を行っています。検体採取については２年目も順調に進んでいますが、検体数の増加にともない、検体の口腔内所見（残存歯数や歯科治療所見）が多様に見られ、また、高齢のご遺体（解剖体）では、残存歯数が少ない場合があり、初年度に採取した口腔内所見によるスコア化に関して、調整が必要となっています。
    日本学術振興会, 基盤研究(C), 北海道大学, 20K10287
  • Evaluate the usefulness of postmortem CT and MRI for drug toxicology
    Grants-in-Aid for Scientific Research
    01 Apr. 2019 - 31 Mar. 2022
    Hyodoh Hideki
    Postmortem CT or MRI can be used to provide a reasonable index of suspicion that a drug or toxic substance may have caused death, but there are limitations to its high accuracy. However, the use of postmortem CT or postmortem MRI can provide a highly accurate index of suspicion that death may have been caused by drugs or toxic substances, but this method is limited in its ability to provide a highly accurate diagnosis.
    The final year's study revealed that postmortem images can be used to objectively evaluate fatty degeneration of the liver, and that they correlate well with histopathological examination results, and can determine metabolic abnormalities caused by drugs and toxic substances with a high degree of accuracy. Further research is needed.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 19K08114
  • Development and application of a new indicator for estimating postmortem interval using a chemical approach
    Grants-in-Aid for Scientific Research
    01 Apr. 2018 - 31 Mar. 2022
    Jin Shigeki
    We analyzed body fluids from cases at various postmortem intervals and found that high concentrations of n-butyric acid were detected in samples obtained from severely decomposed cases. n-Butyric acid was detected in decomposed cases at an average concentration more than 100 and 300 times higher than in non-composed cases, in blood and urine, respectively. These results suggest that the concentration of n-butyric acid in body fluids is a useful indicator of body decomposition. On the other hand, thiosulfate, a marker of hydrogen sulfide poisoning, was detected at high concentrations in severely decomposed cases that was not hydrogen sulfide poisoning, indicating the need for caution in the diagnosis of poisoning.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 18K10117
  • The development of hydrogen sulfide poisoning diagnosis method by measuring thiosulfate concentration with LC-MS/MS
    Grants-in-Aid for Scientific Research
    01 Apr. 2017 - 31 Mar. 2019
    Matoba Kotaro, Hyodoh Hideki, Jin Shigeki
    The thiosulfate concentration in blood has been recognized as a marker of hydrogen sulfide poisoning in forensic medicine. In this study, we established a new method of quantitative analysis of thiosulfate concentration using LC-MS/MS instead of GC-MS, and studied the changes in thiosulfate concentration caused by postmortem decomposition of 3 kinds of body fluids (blood, urine, and pericardial effusion) collected from forensic autopsy cases. The thiosulfate concentration in each body fluid in the decomposed cases (non-hydrogen sulfide poisoning cases) was detected at a high level, at the same level as that in hydrogen sulfide poisoning cases.Therefore, thiosulfate in body fluids is produced by postmortem decomposition regardless of hydrogen sulfide poisoning, and it is necessary to consider the influence of postmortem decomposition in the diagnosis of hydrogen sulfide poisoning based on thiosulfate concentration.
    Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, 17K15874
  • Experimental evaluation of postmortem enhanced CT image and histopathology
    Grants-in-Aid for Scientific Research
    01 Apr. 2016 - 31 Mar. 2019
    Hyodoh Hideki
    We evaluate the influence of infusion on cadaver lung, and to evaluate the mechanism of increasing lung density in postmortem CT. Comparing among the antemortem, and 80 ml injection and 160 ml injection groups, the lung density was relatively increasing after saline injection. The 160 ml injection group presented statistically increased lung density compared with antemortem and the 80 ml injection group. From segmented volume data analysis, the highly edematous lung area was statistically increasing; in contrast, the lung volume was not changed after saline injection. Therefore, depending on the infusion volume, the lung density increases, the aerated lung volume decreases, and the edematous lung volume increases in postmortem CT.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 16K10290