Dec. 2024, American College of Neuropsychopharmacology, ACNP Global Scholarship Program　　　　　　　　　　　　　　　
Ryo Sawagashira

Nov. 2024, 第二回計算論的精神医学研究会, 優秀演題賞　　　　　　　　　　　　　　　
Ryo Sawagashira

Sep. 2024, Hokkaido University, research promotion award　　　　　　　　　　　　　　　
Different properties of neurocognitive imparements among major psychiatric disorders using optimal machine learning.
澤頭亮;堤拓郎

Nov. 2023, 日本生物学的精神医学会, 2022年度国際学会発表奨励賞　　　　　　　　　　　　　　　
Prefrontal neuronal activity related to storage and extinction of short-term memory during oculomotor n-back task in monkeys

Mar. 2023, 北海道大学医学研究院, 第42回高桑榮松奨学基金奨学金　　　　　　　　　　　　　　　

Jun. 2022, The Japanese Society of Psychiatry and Neurology, 国際学会発表賞（個人発表部門）　　　　　　　　　　　　　　　
The oculomotor foraging task: a novel behavioral paradigm to evaluate multiple components of working memory
Ryo Sawagashira

Apr. 2022, The Japanese Society of Neuropsychopharmacology, JSNP Excellent Presentation Award for AsCNP2021　　　　　　　　　　　　　　　
The oculomotor foraging task: a novel behavioral paradigm to evaluate multiple components of working memory
Ryo Sawagashira

Feb. 2022, 北海道医学会, 第40回北海道医学会研究奨励賞　　　　　　　　　　　　　　　
Ryo Sawagashira

Aug. 2021, Hokkaido University, Otowa Prize　　　　　　　　　　　　　　　
Ryo Sawagashira

Aug. 2021, The 43rd Annual Meeting of the Japanese Society of Biological Psychiatry/ The 51th Annual Meeting of the Japanese Society of Neuropsychopharmacology, The 1st Young Psychiatrist Biological Psychiatry Research Encouragement Award　　　　　　　　　　　　　　　
非ヒト霊長類モデルを用いたワーキングメモリの神経メカニズムの解明
Ryo Sawagashira

Aug. 2021, The 43rd Annual Meeting of the Japanese Society of Biological Psychiatry/ The 51th Annual Meeting of the Japanese Society of Neuropsychopharmacology, Featured Presentation Award　　　　　　　　　　　　　　　
Ketamine-induced working memory deficits during oculomotor foraging task in monkeys
Ryo Sawagashira

Dec. 2020, RECBS, Excellent Presentation Award　　　　　　　　　　　　　　　
N-back課題中の前頭連合野ニューロンの活動
澤頭亮

Nov. 2019, Research and Education Center for Brain Science, Excellent Presentation Award　　　　　　　　　　　　　　　
霊長類モデルを用いた作業記憶の神経メカニズムの解明
Ryo Sawagashira

Aug. 2019, 第99回日本生理学会北海道地方会, 研究奨励賞　　　　　　　　　　　　　　　
採餌行動のモデルとケタミンによる変化
澤頭亮

Jul. 2016, Japanese Society of Neuropsychopharmacology, JSNP Excellent Presentation Award　　　　　　　　　　　　　　　
Ryo Sawagashira

Delirium Induced by Rapid Titration of Osilodrostat in a Patient With Cushing’s Disease: A Case Report
Toshiyuki Ishikawa, Ryo Sawagashira, Haruna Ito, Hiraku Kameda, Takahiro A Kato
Cureus, Springer Science and Business Media LLC, 11 Nov. 2025, [Peer-reviewed], [Corresponding author]
English, Scientific journal

Clozapine‐induced slowing in quantitative EEG: Delta–theta amplification and alpha peak shift in TRS patients
Ryo Sawagashira, Shuhei Ishikawa, Atsuhito Toyomaki, Toru Horinouchi, Naoki Hashimoto, Takahiro A. Kato
Psychiatry and Clinical Neurosciences Reports, 4, 3, Wiley, 11 Aug. 2025, [Peer-reviewed], [Lead author, Corresponding author]
Scientific journal

Neural correlates of memory updating in the primate prefrontal cortex
Ryo Sawagashira, Masaki Tanaka
Communications Biology, 8, 1, Springer Science and Business Media LLC, 09 Jun. 2025, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal, Abstract

Working memory allows temporary storage and manipulation of information during cognitive tasks. While the primate lateral prefrontal cortex (PFC) is involved in working memory, little is known about neuronal activity during memory updating. We trained macaque monkeys on an oculomotor n-back task, requiring them to remember locations of sequentially presented visual stimuli and generate a saccade to the location of the most recent or previous stimulus based on task rules. Many PFC neurons showed transient activity when a memory of a particular stimulus location was no longer needed, whereas others showed sustained activity for remembered locations. Decoding analysis successfully predicted future target selection based on the task rule from neuronal activity, indicating that these neuronal populations contain sufficient information to guide behavior. Furthermore, electrical stimulation at recording sites erased specific spatial memories, demonstrating a causal role of prefrontal neurons in maintaining and updating short-term memory.

Neural correlates of memory updating in the primate prefrontal cortex
Ryo Sawagashira, Masaki Tanaka
biorxiv, Cold Spring Harbor Laboratory, 30 Jan. 2025
English, Working memory is the ability to temporarily hold and manipulate information during cognitive tasks and is essential for complex behaviors and thinking. Although the primate lateral prefrontal cortex is involved in working memory and the neural representation of short-term memory has been reported, little is known about neuronal activity during memory updating. We trained macaque monkeys to perform an oculomotor version of the n-back task, in which the animals were required to remember the location of serially presented visual stimuli and generate a saccade to the location of the most recent or previous stimulus according to the instructions. We found that many neurons in the lateral prefrontal cortex showed transient activity when the memory of a particular stimulus location was no longer needed, whereas other neurons showed sustained activity when the stimulus location was maintained in memory. Decoding analysis successfully predicted future target selection from neuronal activity, indicating that these neuronal populations contain sufficient information to guide behavior. Furthermore, electrical stimulation applied to recording sites during the task erased specific spatial memories, suggesting that these neurons are causally involved in the retention of short-term memories and their dynamic control.

Assessment of factors associated with antipsychotic-induced weight gain: A nationwide cohort study
Shuhei Ishikawa, Naoki Hashimoto, Ryo Okubo, Ryo Sawagashira, Ryodai Yamamura, Yoichi M. Ito, Norihiro Sato, Ichiro Kusumi
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 111231, 111231, Elsevier BV, Dec. 2024
Scientific journal

【注意と注意障害】視覚探索における注意と記憶
澤頭 亮, 田中 真樹
BRAIN and NERVE: 神経研究の進歩, 76, 6, 0709, 0714, (株)医学書院, Jun. 2024
Japanese

Cardiovascular adverse reactions associated with escitalopram in patients with underlying cardiovascular diseases: a systematic review and meta-analysis
Kenichi Kimura, Hisashi Narita, Hissei Imai, Hisashi Akiyama, Shuhei Ishikawa, Ryo Sawagashira, Tomoyuki Isoyama, Mariko Nohara, Michiyo Kawamura, Yukari Kono, Takuya Saito, Ichiro Kusumi
Frontiers in Psychiatry, 14, Frontiers Media SA, 22 Sep. 2023
Scientific journal, Background

Despite the anticipated efficacy of escitalopram in treating depression and anxiety in individuals with preexisting cardiovascular conditions, persistent concerns regarding its adverse effects have emerged. In this systematic review, we aimed to evaluate the cardiovascular safety profile of escitalopram compared with that of placebo in patients with underlying cardiovascular disease.

Methods

We used a predefined search strategy in PubMed, Cochrane Central Register of Controlled Trials, Embase, International Clinical Trials Registry Platform, and ClinicalTrials.gov to identify studies evaluating adverse cardiovascular reactions to escitalopram in patients with underlying cardiovascular disease. Randomized controlled trials (RCTs) that provided results on cardiovascular safety outcomes were included. Two independent reviewers screened the abstracts and full texts of the individual studies. The risk of bias was assessed using version 2 of the Cochrane risk-of-bias tool for randomized trials. The certainty of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation approach.

Results

The primary outcomes were the frequency of major adverse cardiovascular events (MACE), QTc prolongation, and discontinuation of study medication. We identified 5 RCTs with 773 participants who met the inclusion criteria. Escitalopram was not associated with significantly increased risk of MACE (risk ratio [RR] = 1.85; 95% confidence interval [CI] 0.80 to 4.26; I² 0%; 5 RCTs; n = 773, moderate certainty of evidence), discontinuation of study medication (RR = 1.03; 95% CI 0.84–1.26; I² 0%; 5 RCTs; n = 773, low certainty of evidence), and QTc prolongation (RR = 1.20; 95% CI 0.76–1.90; I² 0%; 4 RCTs; n = 646, low certainty of evidence).

Conclusion

Escitalopram does not significantly increase the risk of cardiovascular adverse reactions compared with placebo in patients with underlying cardiovascular disease. However, the presence of wide CIs and the limited number of included studies highlight the need for further studies with larger sample sizes to enhance the precision and reliability of these findings.

Systematic review registration: International Prospective Register of Systematic Reviews [CRD42022298181].

Pharmacological interventions for social cognitive impairments in schizophrenia: A protocol for a systematic review and network meta-analysis
Yuji Yamada, Ryo Okubo, Hisateru Tachimori, Takashi Uchino, Ryotaro Kubota, Hiroki Okano, Shuhei Ishikawa, Toru Horinouchi, Keisuke Takanobu, Ryo Sawagashira, Yumi Hasegawa, Yohei Sasaki, Motohiro Nishiuchi, Takahiro Kawashima, Yui Tomo, Naoki Hashimoto, Satoru Ikezawa, Takahiro Nemoto, Norio Watanabe, Tomiki Sumiyoshi
Frontiers in Psychology, 13, Frontiers Media SA, 03 Aug. 2022
Scientific journal, Background

Social cognitive impairments adversely affect social functioning (e.g., employment status) in patients with schizophrenia. Although pharmacological interventions have been suggested to provide some benefits on social cognition, little information is available on the comparative efficacy of pharmacotherapy. Thus, the aim of this planned systematic review and network meta-analysis is to perform a quantitative comparison of the effects of various psychotropic drugs, including supplements, on social cognition disturbances of schizophrenia.

Methods

The literature search will be carried out using the PubMed, Embase, Cochrane Central Register of Controlled Trials, PsycINFO, ClinicalTrials.gov, and International Clinical Trials Registry Platform databases from inception onward. Randomized controlled trials that examined the efficacy of drugs in social cognitive disturbances will be included, based on the most recent studies and the broader literature than previously searched. This protocol defines a priori the methods that will be used for study selection, data collection, quality assessment, and statistical syntheses.

Discussion

The findings this work are expected to help promote the development of better therapeutics of social cognitive impairments in schizophrenia and related psychiatric conditions.

Systematic Review Registration

[www.crd.york.ac.uk/prospero], identifier [CRD42021293224].

Nicotine promotes the utility of short-term memory during visual search in macaque monkeys.
Ryo Sawagashira, Masaki Tanaka
Psychopharmacology, 08 Jul. 2022, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
English, Scientific journal, RATIONALE: The central cholinergic system is a major therapeutic target for restoring cognitive functions. Although manipulation of cholinergic signaling is known to alter working memory (WM), the underlying mechanism remains unclear. It is widely accepted that WM consists of multiple functional modules, one storing short-term memory and the other manipulating and utilizing it. A recently developed visual search task and a relevant model can be used to assess multiple components of WM during administration of acetylcholine receptor (AChR)-related substances. OBJECTIVES: The effects of systemic administration of AChR-related agents on WM and eye movements were examined during the oculomotor foraging task. METHODS: Three monkeys performing the task received an intramuscular injection of saline or the following AChR-related agents: nicotine (24 or 56 μg/kg), mecamylamine (nicotinic AChR antagonist, 1.0 mg/kg), oxotremorine (muscarinic AChR agonist, 3.0 µg/kg), and scopolamine (muscarinic AChR antagonist, 20 μg/kg). The task was to find a target among 15 identical objects by making eye movements within 6 s. The data were analyzed according to the foraging model that incorporated three parameters. RESULTS: Nicotine and mecamylamine significantly increased the utility but not the capacity of short-term memory, while muscarinic AChR-related agents did not alter any WM parameters. Further regression analyses with a mixed-effect model showed that the beneficial effect of nicotine on memory utility remained after considering eye movement variability, but the beneficial effect of mecamylamine disappeared. CONCLUSIONS: Nicotine improves visual search, mainly by increasing the utility of short-term memory, with minimal changes in oculomotor parameters.

Subthreshold Change in Glycated Hemoglobin and Body Mass Index After the Initiation of Second-Generation Antipsychotics Among Patients With Schizophrenia or Bipolar Disorder
Ryo Sawagashira, Ryodai Yamamura, Ryo Okubo, Naoki Hashimoto, Shuhei Ishikawa, Yoichi M. Ito, Norihiro Sato, Ichiro Kusumi
The Journal of Clinical Psychiatry, 83, 3, Physicians Postgraduate Press, Inc, 30 Mar. 2022, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal, Objective: The risk of diabetes development has been reported to differ among second-generation antipsychotics (SGAs). However, few studies have focused on the subthreshold change in glycated hemoglobin (HbA1c). Therefore, this study examined the subthreshold change in HbA1c and change in body mass index (BMI) 3 months after patients initiated one of 6 SGAs widely prescribed in Japan. Methods: This is a prospective cohort study of patients followed up based on the Japanese blood glucose monitoring guidelines for patients with schizophrenia. We collected eligible patients' demographic data, medication history, blood tests, and weight measurements both at baseline and 3 months after recruitment, between April 2013 and March 2015. In the 378 patients with schizophrenia, schizoaffective disorder, and bipolar disorder based on ICD-10, we compared the subthreshold change in HbA1c and the change in BMI 3 months after antipsychotic initiation by using multivariate regression analysis. Results: The subthreshold change in HbA1c 3 months after initiating blonanserin was significantly lower compared with olanzapine (B = -0.17, 95% CI = -0.31 to -0.04). In addition, the change in BMI 3 months after initiating blonanserin and aripiprazole was significantly lower compared with olanzapine (B = -0.93, 95% CI = -1.74 to -0.12; B = -0.71, 95% CI = -1.30 to -0.12, respectively). Conclusions: This is the first study to clarify the differences in the subthreshold change in HbA1c among SGAs. Our results suggest that blonanserin is likely to be a favorable treatment for patients with high risk of diabetes. Trial Registration: UMIN Clinical Trial Registry identifier: UMIN000009868.

The type rather than the daily dose or number of antipsychotics affects the incidence of hyperglycemic progression
Shuhei Ishikawa, Ryodai Yamamura, Naoki Hashimoto, Ryo Okubo, Ryo Sawagashira, Yoichi M. Ito, Norihiro Sato, Ichiro Kusumi
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 113, 110453, 110453, Elsevier BV, Mar. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, There have been concerns that antipsychotics increase the incidence of hyperglycemic progression. Many factors have been suggested to contribute to the risk of antipsychotic-induced hyperglycemic progression, including the type, daily dose, and number of antipsychotics; however, few studies have examined these relationships. This study aimed to examine the affect of antipsychotic treatment-associated factors on hyperglycemic progression, after adjustment for the affect of background factors suggested to be associated with hyperglycemic progression. This was a nationwide, multicenter, prospective cohort study examining the incidence of hyperglycemic progression during a 12 mo period following the initiation of newly prescribed antipsychotic medication. Demographic data, medication history, and blood test values were collected from 631 study participants with normal blood glucose levels at baseline for 12 mo. The primary endpoint (incidence of hyperglycemic progression) was defined as progression from normal to prediabetic or probable diabetic status, and was evaluated based on the Japanese monitoring guidance in patients with schizophrenia. To further examine the affect of antipsychotics on glucose metabolism over time, we examined changes in HbA1c levels 3, 6, and 12 mo after the initiation of treatment with each antipsychotic. We found that treatment with zotepine and clozapine was associated with a significantly high incidence of hyperglycemic progression. Furthermore, changes in HbA1c levels 6 mo after the initiation of zotepine treatment were significantly higher than those following blonanserin and haloperidol treatments. In contrast, there was no significant difference in the change in total cholesterol, triglycerides, HDL cholesterol, and BMI during the same period. Moreover, the "daily dose" and "number" of antipsychotics did not show an association with the incidence of hyperglycemic progression. However, in a post hoc analysis in which the antipsychotics were divided into two groups according to the strength of blockade of H1, M1, M3, and 5-HT2C receptors, the incidence of hyperglycemic progression was higher in the medium- and high-daily dose groups than in the low-daily dose group in the antipsychotic group with strong blockade of these receptors. Our study indicated that the type of antipsychotic had a greater affect on the incidence of hyperglycemic progression than the daily dose of antipsychotics or their number. Among these, zotepine was most likely to increase the incidence of hyperglycemic progression, suggesting the need for caution when these antipsychotics are prescribed.

Sick Sinus Syndrome Mimicking Autonomic Dysfunction of Dementia With Lewy Bodies
Ryo Sawagashira, Yoshihisa Sasagawa, Mayumi Matsukura, Yuji Takamaru
Cureus, 24 Apr. 2021, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Ketamine-induced alteration of working memory utility during oculomotor foraging task in monkeys
Ryo Sawagashira, Masaki Tanaka
eneuro, ENEURO.0403, 20.2021, Society for Neuroscience, 09 Mar. 2021, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
English, Scientific journal, Impairments of working memory are commonly observed in a variety of neurodegenerative disorders but they are difficult to quantitatively assess in clinical cases. Recent studies in experimental animals have used low-dose ketamine (an NMDA receptor antagonist) to disrupt working memory, partly mimicking the pathophysiology of schizophrenia. Here, we developed a novel behavioral paradigm to assess multiple components of working memory and applied it to monkeys with and without ketamine administration. In an oculomotor foraging task, the animals were presented with 15 identical objects on the screen. One of the objects was associated with a liquid reward, and monkeys were trained to search for the target by generating sequential saccades under a time constraint. We assumed that the occurrence of recursive movements to the same object might reflect working memory dysfunction. We constructed a "foraging model" that incorporated 1) memory capacity, 2) memory decay and 3) utility rate; this model was able to explain more than 92% of the variations in behavioral data obtained from three monkeys. Following systemic administration of low dosages of ketamine, the memory capacity and utility rate were dramatically reduced by 15% and 57%, respectively, while memory decay remained largely unchanged. These results suggested that the behavioral deficits during the blockade of NMDA receptors were mostly due to the decreased usage of short-term memory. Our oculomotor paradigm and foraging model appear to be useful for quantifying multiple components of working memory and could be applicable to clinical cases in future studies.Significance StatementWorking memory is often difficult to quantitatively assess in clinical cases, although deficiencies in working memory have been reported in a variety of disorders. Here, we developed a novel oculomotor foraging paradigm and devised a relevant model for accurately evaluating several parameters of working memory during visual search. We applied it to monkeys with and without administration of low-dose ketamine, which has been used to produce animal models of schizophrenia. Subanesthetic doses of ketamine dramatically reduced the use of short-term memory and increased the rate of exploratory choice, whereas the changes in memory capacity and memory decay were only modest. Our behavioral paradigm and the proposed model will provide a better understanding of the pathophysiology of working memory dysfunction.

Case of myxedema coma induced by lithium carbonate in a patient with schizophrenia.
Ryo Sawagashira
Psychiatry and clinical neurosciences, 72, 2, 131, 131, Wiley, 23 Dec. 2017, [Peer-reviewed], [Lead author, Corresponding author]
Scientific journal

Transient lesions of the splenium of the corpus callosum following rapid withdrawal of levetiracetam
Ryo Sawagashira, Hisashi Narita, Naoki Hashimoto, Tsugiko Kurita, Shin Nakagawa, Takuya Saitoh, Ichiro Kusumi
Epileptic Disorders, 19, 3, 379, 382, Sep. 2017, [Peer-reviewed], [Lead author]
English, Scientific journal

Clinical pharmacokinetic interactions between lamotrigine and hormonal contraceptives in bipolar I disorder
Ryo Sawagashira, Yutaka Fujii, Ichiro Kusumi
Psychiatry and Clinical Neurosciences, 71, 4, 290, 290, Apr. 2017, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal

数年ぶりに亜昏迷を呈したドパミン過感受性精神病患者の治療経過 ~ aripiprazole への置換と献身的な看護の観点から~　　　　　　　　　　　　　　　
澤頭 亮, 笹川 嘉久, 松倉 真弓, 髙丸 勇司
小樽市立病院誌, 第6巻, 1号, 63, 67, 2017, [Peer-reviewed], [Lead author]
Japanese, Scientific journal

Rapidly Progressive Tetraparesis with Ossification of the Posterior Longitudinal Ligament (OPLL)
Ryo Sawagashira, Takashi Watari, Yasuharu Tokuda
JOURNAL OF GENERAL AND FAMILY MEDICINE, 17, 2, 158, 159, Jun. 2016, [Peer-reviewed]
English, Scientific journal

[Case Report; A case of lipoid pneumonia mimicking lung cancer].
Ryo Sawagashira
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 105, 2, 281, 285, Japanese Society of Internal Medicine, 01 Feb. 2016, [Peer-reviewed], [Invited], [Lead author]
Japanese, Scientific journal

新精神科専門医制度における内科教育の実践 新医師臨床研修制度を通して見ててくる精神科医の意識変化　　　　　　　　　　　　　　　
澤頭 亮, 佐藤 明, 大矢 希, 中神 由香子, 堀之内 徹, 精神神経学雑誌, 2019特別号, S341, S341, Jun. 2019
(公社)日本精神神経学会, Japanese

新医師臨床研修制度を通して見えてくる精神科医の意識変化
澤頭亮, 佐藤明, 大矢希, 中神由香子, 堀之内徹, 日本精神神経学会総会プログラム・抄録集, 115th, 2019

精神科医療の普及と教育に対するガイドラインの効果に関する研究 北海道地区、うつ病講習についての報告　　　　　　　　　　　　　　　
澤頭 亮, 橋本 直樹, 山本 智也, 稲田 健, 渡邊 衡一郎, 橋本 亮太, 久住 一郎, 日本うつ病学会総会・日本認知療法・認知行動療法学会プログラム・抄録集, 14回・17回, 247, 247, Jul. 2017
日本うつ病学会・日本認知療法・認知行動療法学会, Japanese

Levetiracetamの急激な中止により引き起こされた一過性脳梁膨大部病変の一例　　　　　　　　　　　　　　　
澤頭 亮, 成田 尚, 橋本 直樹, 栗田 紹子, 中川 伸, 久住 一郎, 日本神経精神薬理学会年会プログラム・抄録集, 46回, 163, 163, Jul. 2016
(一社)日本神経精神薬理学会, Japanese

Best Articles of the Year) 短 期 記 憶 の 消 去 に 関 与 す る 外 側 前 頭 前 野 ニ ュ ー ロ ン　　　　　　　　　　　　　　　
澤頭亮, 田中真樹
北海道医学雑誌第100巻2号, Nov. 2025, [Joint work]

My Research: Toward Becoming a Neuroscience-Oriented Psychiatrist　　　　　　　　　　　　　　　
澤頭 亮
Japanese Journal of Biological Psychiatry Vol.36, No.3, 2025, Sep. 2025, [Single work]

BRAIN and NERVE Vol.76 No.6 2024年 06月号 特集 注意と注意障害　　　　　　　　　　　　　　　
澤頭 亮, 田中 真樹, 視覚探索における注意と記憶
医学書院, Jun. 2024, [Joint work]

COVID-19 & clinical management of mental health issues　　　　　　　　　　　　　　　
監訳, 井上 猛, 本屋敷 美奈, 翻訳, 安藝 森央, 石井 義隆, 入來 晃久, 川竹 絢子, 北岡 淳子, 木山 信明, 倉持 泉, 香田 将英,下島 里音, 高松 直岐, 寺尾 樹, 増田 将人, 山口 泰成, 大矢 希, 澤頭 亮, 福島 弘之, Long Acting Injection
Nov. 2020, [Joint translation]

Aspirin as an add-on treatment to antipsychotics for people schizophrenia　　　　　　　　　　　　　　　
Ryo Sawagashira
Cochrane Library, Nov. 2019, [Supervisor]

The role of the evolutionary approach in psychiatry　　　　　　　　　　　　　　　
Ryo Sawagashira
World Psychiatry, vol. 18, Number 3, Oct. 2019, [Joint translation]

The all‐encompassing perspective of the mental health care patient　　　　　　　　　　　　　　　
Ryo Sawagashira
World Psychiatry, vol. 18, Number 3, Oct. 2019, [Joint translation]

Moderation, mediation, and moderated mediation　　　　　　　　　　　　　　　
Ryo Sawagashira
World Psychiatry, vol. 18, Number 3, Oct. 2019, [Joint translation]

Therapeutic change processes link and clarify targets and outcomes　　　　　　　　　　　　　　　
Ryo Sawagashira
World Psychiatry, vol. 18, Number 3, Oct. 2019, [Joint translation]

Electroconvulsive therapy for treatment-resistant schizophrenia　　　　　　　　　　　　　　　
Ryo Sawagashira
Cochrane Library, Oct. 2019, [Supervisor]

Clinical Trial Education and Language Translation: Two Recent JYPO Activities　　　　　　　　　　　　　　　
Ryo Sawagashira, Language Translation from English to Japanese
The Bulletin of the AFPA The Winter 2019 Issue, Feb. 2019, [Joint work]

Digital phenotyping: a global tool for psychiatry　　　　　　　　　　　　　　　
Ryo Sawagashira
Oct. 2018, [Joint translation]

The contribution of the WPA to the production of the ICD‐11 chapter on mental, behavioural or neurodevelopmental disorders　　　　　　　　　　　　　　　
Ryo Sawagashira
Jun. 2018, [Joint translation]

The WPA website: rich in content, excellent in performance　　　　　　　　　　　　　　　
Ryo Sawagashira
Jun. 2018, [Joint translation]

WPA Position Statement on Banning the Participation of Psychiatrists in the Interrogation of Detainees　　　　　　　　　　　　　　　
Ryo Sawagashira
Jun. 2018, [Joint translation]

Mainstreaming psychiatry: implementing the WPA Action Plan 2017‐2020　　　　　　　　　　　　　　　
Ryo Sawagashira
Jun. 2018, [Joint translation]

WPA scientific publications in the triennium 2014‐2017　　　　　　　　　　　　　　　
Ryo Sawagashira
Feb. 2018, [Joint translation]

WPA Scientific Sections activities in the triennium 2014‐2017　　　　　　　　　　　　　　　
Ryo Sawagashira
Feb. 2018, [Joint translation]

News from WPA Scientific Sections　　　　　　　　　　　　　　　
Ryo Sawagashira
2017, [Joint translation]

Report on WPA activities in the triennium 2014-2017　　　　　　　　　　　　　　　
Ryo Sawagashira
2017, [Joint translation]

WPA International Competency-Based Curriculum for Mental Health Providers on Intimate Partner Violence and Sexual Violence Against Women　　　　　　　　　　　　　　　
Ryo Sawagashira
2017, [Joint translation]

A reassessment of the relationship between depression and all-cause mortality in 3,604,005 participants from 293 studies　　　　　　　　　　　　　　　
Ryo Sawagashira
2017, [Joint translation]

Causes and predictors of premature death in first-episode schizophrenia spectrum disorders　　　　　　　　　　　　　　　
澤頭亮
2017, [Joint translation]

Traditional marijuana, high-potency cannabis and synthetic cannabinoids: increasing risk for psychosis.　　　　　　　　　　　　　　　
澤頭亮
2016, [Joint translation]

修正型電気痙攣療法施行中、酸素飽和度が著明に低下した症例において筋弛緩薬をスキサメトニウムからロクロニウムへ変更し、酸素飽和度の低下を防止できた一例　　　　　　　　　　　　　　　
袋井 謙一郎, 石川 修平, 大久保 亮, 尾崎 孝爾, 澤頭 亮, 成田 尚, 山邊 茜, 加藤 隆弘
北海道精神神経学会第148回例会, 14 Dec. 2025, Japanese, Oral presentation

曝露反応妨害法と薬物療法の適正化により改善した強迫症状を伴う 治療抵抗性統合失調症の一例　　　　　　　　　　　　　　　
北海道精神神経学会第148回例会, 14 Dec. 2025, Japanese, Oral presentation

バルベナジン投与で改善した 遅発性ジスキネジアの一例： 動画併用による治療効果の可視化　　　　　　　　　　　　　　　
土田 直, 澤頭 亮, 石井 一, 石川 修, 橋本 直, 加藤 隆
北海道精神神経学会第148回例会, 14 Dec. 2025, Japanese, Oral presentation

Cognitive Heterogeneity in Mood Disorders　　　　　　　　　　　　　　　
澤頭 亮、堤 拓朗、渡辺 隼人、豊巻 敦人、大久保 亮、 橋本 直樹、加藤 隆弘
第44回躁うつ病の薬理・生化学的研究懇話会, 31 Oct. 2025, Japanese, Oral presentation
31 Oct. 2025 - 01 Nov. 2025

Different properties of neurocognitive impairments among bipolar disorder and depression using optimal machine learning　　　　　　　　　　　　　　　
Ryo Sawagashira, Takuro Tsutsumi, Atsuhito Toyomaki, Chiemi Kubota, Mariko Nohara, Hayato Watanabe, Ryo Okubo, Naoki Hashimoto, Takahiro A. Kato
27th Annual Conference of the International Society for Bipolar Disorders, 17 Sep. 2025, English, Poster presentation
17 Sep. 2025 - 19 Sep. 2025

躁うつ病とうつ病における神経認知機能障害の違い　　　　　　　　　　　　　　　
澤頭亮, 堤拓朗, 久保田千絵美, 渡辺隼人, 野原万梨子, 豊巻敦人, 大久保亮, 橋本直樹
CPSY TOKYO 2025, 17 Feb. 2025, Japanese, Poster presentation
17 Feb. 2025 - 18 Feb. 2025

Visual search課題を用いたワーキングメモリの定量化　　　　　　　　　　　　　　　
15 Nov. 2024, Oral presentation

Prefrontal neuronal activity related to storage and extinction of short-term memory during oculomotor n-back task in monkeys　　　　　　　　　　　　　　　
Ryo Sawagashira
第45回日本生物学的精神医学会, 06 Nov. 2023, English, Poster presentation
05 Nov. 2023 - 07 Nov. 2023, [Invited]

Prefrontal neuronal activity related to storage and extinction of short-term memory during oculomotor n-back task in monkeys　　　　　　　　　　　　　　　
Ryo Sawagashira, Masaki Tanaka
Neuroscience 2022 (Society for Neuroscience), 13 Nov. 2022, English, Poster presentation
12 Nov. 2022 - 16 Nov. 2022

Neuronal activity in the primate prefrontal cortex during the oculomotor n-back task　　　　　　　　　　　　　　　
Ryo Sawagashira, Masaki Tanaka
NEURO2022, 01 Jul. 2022, English, Poster presentation

The oculomotor foraging task: a novel behavioral paradigm to evaluate multiple components of working memory　　　　　　　　　　　　　　　
Ryo Sawagashira
7th Congress of Asian College of Neuropsychopharmacology, 22 Oct. 2021, English, Oral presentation

Ketamine-induced working memory deficits during oculomotor foraging task in monkeys　　　　　　　　　　　　　　　
Ryo Sawagashira, Masaki Tanaka
The 43rd Annual Meeting of the Japanese Society of Biological Psychiatry/ The 51th Annual Meeting of the Japanese Society of Neuropsychopharmacology, 15 Jul. 2021, Japanese, Oral presentation
14 Jul. 2021 - 16 Jul. 2021

N-back課題における前頭連合野ニューロンの活動　　　　　　　　　　　　　　　
Ryo Sawagashira, Masaki Tanaka
2020年度第2回時間生成学領域会議, 30 Jan. 2021, Japanese, Poster presentation

N-back課題中の前頭連合野ニューロンの神経活動　　　　　　　　　　　　　　　
澤頭亮
RECBS, 15 Dec. 2020, Oral presentation

N-back課題中の前頭連合野ニューロンの活動　　　　　　　　　　　　　　　
澤頭 亮
日本生理学会北海道地方会, 29 Aug. 2020, Japanese, Oral presentation

The oculomotor foraging task:a novel behavioral paradigm to evaluate working memory capacity and utility　　　　　　　　　　　　　　　
Ryo Sawagashira
The 97th Annual Meeting of the Physiological Society of Japan, 17 Mar. 2020, Poster presentation
17 Mar. 2020 - 19 Mar. 2020

新規採餌課題を用いた作業記憶の定量化　　　　　　　　　　　　　　　
澤頭亮
生理学研究所研究会〜行動の多様性を支える神経基盤とその動作様式の解明〜, 13 Dec. 2019, Japanese
[Domestic Conference]

採餌行動課題を用いたワーキングメモリの定量化　　　　　　　　　　　　　　　
澤頭亮
北海道大学部局横断シンポジウム, 06 Nov. 2019, Japanese, Poster presentation
[Domestic Conference]

霊長類モデルを用いた作業記憶の神経メカニズムの解明　　　　　　　　　　　　　　　
澤頭亮
2019年度脳科学研究教育センター合宿研修, 02 Nov. 2019, Japanese, Oral presentation
[Domestic Conference]

採餌行動のモデルとケタミンによる変化　　　　　　　　　　　　　　　
澤頭亮
日本生理学会北海道地方会, 31 Aug. 2019, Japanese, Oral presentation
[Domestic Conference]

採餌行動課題を用いた作業記憶の定量化とケタミンによる変化　　　　　　　　　　　　　　　
澤頭亮
新学術領域時間生成学第二回領域会議, 20 Aug. 2019, Japanese, Poster presentation
[Domestic Conference]

Ketamine-induced alterations in memory capacity and exploratory behavior during oculomotor foraging in monkey　　　　　　　　　　　　　　　
澤頭亮
NEURO2019, 26 Jul. 2019, English, Poster presentation
[Domestic Conference]

新医師臨床研修制度を通して見えてくる精神科医の意識変化　　　　　　　　　　　　　　　
澤頭亮
第115回日本精神神経学会, 22 Jun. 2019, Japanese, Nominated symposium
[Domestic Conference]

ケタミン投与による採餌行動の変化　　　　　　　　　　　　　　　
澤頭亮
新学術領域時間生成学第一回領域会議, 03 Feb. 2019, Japanese, Poster presentation
[Domestic Conference]

What should consultation liaison psychiatry be in aging societies?　　　　　　　　　　　　　　　
Ryo Sawagashira
第114回日本精神神経学会, Jun. 2018, English, Oral presentation
[Domestic Conference]

精神科医療の普及と教育に対するガイドラインの効果に関する研究-北海道地区、うつ病講習についての報告-　　　　　　　　　　　　　　　
Ryo Sawagashira
第14回日本うつ病学会, Jul. 2017, Japanese, Poster presentation
[Domestic Conference]

mECT施行前に肺塞栓症の診断がついた悪性緊張病の一例　　　　　　　　　　　　　　　
澤頭亮
第131回北海道精神神経学会例会, 2017, Japanese, Oral presentation
[Domestic Conference]

A case of transient splenial lesion of the corpus callosum following rapid withdrawal of levetiracetam　　　　　　　　　　　　　　　
Ryo Sawagashira
日本神経精神薬理学会ソウル大会, Jul. 2016, Japanese, Oral presentation
[International presentation]

自律神経症状と洞不全症候群の関連が示唆されたDLBの一例　　　　　　　　　　　　　　　
Ryo Sawagashira
第113回日本精神神経学会, Jun. 2016, Japanese, Poster presentation
[Domestic Conference]

2か月周期の軽躁病相を繰り返す警察訓練生の一例　　　　　　　　　　　　　　　
Ryo Sawagashira
精神病理クリニカルカンファレンス, May 2016, Japanese, Oral presentation
[Domestic Conference]

ペースメーカー挿入により、精神症状の改善が得られたprobable DLBの一例　　　　　　　　　　　　　　　
Ryo Sawagashira
第130回北海道精神神経学会例会, 2016, Japanese, Oral presentation
[Domestic Conference]

肺癌との鑑別が困難であったリポイド肺炎の1例　　　　　　　　　　　　　　　
澤頭亮
日本内科学会関東地方会, 2015, Japanese
[Domestic Conference]

抗凝固療法中に生じた腸腰筋血腫が胸腔内に穿破した1例　　　　　　　　　　　　　　　
澤頭亮
日本内科学会関東地方会, 2014, Japanese, Oral presentation
[Domestic Conference]

大学院講義 医学総論 健康管理医学　　　　　　　　　　　　　　　
Apr. 2025 - Present

脳科学研究の展開（実習）　　　　　　　　　　　　　　　
北海道大学脳科学教育研究センター
Apr. 2023 - Mar. 2024

脳科学研究の展開（講義）　　　　　　　　　　　　　　　
北海道大学脳科学研究教育センター
Apr. 2023 - Mar. 2024

Physiology II (Association cortex)　　　　　　　　　　　　　　　
School of Medicine, Hokkaido University
Oct. 2022 - Mar. 2024

General Education Seminar (Freshman Seminar) Invitation to Brain Science at Hokkaido University　　　　　　　　　　　　　　　
Hokkaido University
Apr. 2022 - Mar. 2024

Experience-based Practice for Medical Students （Neurophysiology）　　　　　　　　　　　　　　　
Hokkaido University, School of Medicine
Apr. 2018 - Mar. 2024

Physiology Practice for Medical Students (Electrocardiogram)　　　　　　　　　　　　　　　
Hokkaido University, School of Medicine
Apr. 2018 - Mar. 2024

非ヒト霊長類モデルを用いた前頭連合野における記憶消去活動の成因に関する探索的研究
科学研究費助成事業
Apr. 2024 - Mar. 2027
Ryo Sawagashira
日本学術振興会, 若手研究, 北海道大学, 24K18604

Different properties of neurocognitive imparements among major psychiatric disorders using optimal machine learning.　　　　　　　　　　　　　　　
第10回部局横断シンポジウム 研究助成
Sep. 2024 - Mar. 2025
澤頭亮
Hokkaido University, Principal investigator

統合失調症における作業記憶課題中の固視微動と注意障害の関連　　　　　　　　　　　　　　　
北海道大学大学院医学研究院学術奨励基金 黎風
Apr. 2024 - Mar. 2025
北海道大学大学院医学研究院, Principal investigator

非ヒト霊長類を用いた短期記憶を操作する神経メカニズムの解明とその障害の病態理解　　　　　　　　　　　　　　　
科学研究費助成事業 研究活動スタート支援
31 Aug. 2022 - 31 Mar. 2024
澤頭 亮
日本学術振興会, 研究活動スタート支援, 北海道大学, 22K20674

非ヒト霊長類を用いた作業記憶の消去に関連した前頭連合野神経活動の成因に関する研究　　　　　　　　　　　　　　　
研究助成（奨励）
Jun. 2023 - Mar. 2024
Ryo Sawagashira
The Akiyama Life Science Foundation, Hokkaido University, Principal investigator

統合失調症における作業記憶の定量化と中枢神経作用薬の機序の解明　　　　　　　　　　　　　　　
北海道大学大学院医学研究院学術奨励基金 黎風
Apr. 2022 - Mar. 2023
澤頭亮
北海道大学大学院医学研究院

Neural mechanisms underlying the central execution system for working memory in the primates
Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows
25 Apr. 2019 - 31 Mar. 2022
澤頭 亮
「霊長類モデルを用いた作業記憶を更新する神経メカニズムの解明」を研究課題として掲げ、複数の研究を同時並行で進めている。前年度までの進捗状況をふまえつつ、本年度の研究実施計画を述べる。
前年度においては、主に行動薬理実験（研究実施計画記載の②）の進捗が大きく、様々な研究会や国内学会で発表の機会を得て、専門家と積極的にディスカッションした。昨年末から英語論文としてまとめ、概ね投稿準備が整った。令和２年中の採択を目指している。同課題は、ヒトを対象とした心理物理実験も視野に入れた研究であり、その実験準備も開始する。
一方、2-back課題を用いた空間的作業記憶の更新に関わる神経活動の評価と操作（研究実施計画記載の①）に関しては、先行していた個体からの記録実験が不十分であったため、新規個体に対して課題のトレーニングを行い、昨年末から記録実験を開始した。現在までに、作業記憶のスレーブシステム（特別研究員申請書「研究の背景と問題点」に記載）を表象する神経活動は記録できているものの、メインの中央実行系を表象する神経活動は未だ発見できていない。従って、現有の個体からの記録実験を精力的に行いつつ、追加で新規個体に課題を訓練し、本年度からすぐに記録実験を開始できるように準備を行っている。
また、視覚探索課題における眼球運動特性のtACSによる操作（研究実施計画記載の③）に関しては、広範囲の脳領域に対して、様々な組み合わせの刺激を与える必要があるため、特殊な頭部固定方法が必要である。前年度は、そのための準備に時間を要した。本年度は、実験環境を早期に完成させ、新規個体に対して課題のトレーニングを開始する。
Japan Society for the Promotion of Science, Grant-in-Aid for JSPS Fellows, Hokkaido University, 19J21332

白糠町立庶路学園自主研修　　　　　　　　　　　　　　　
25 May 2023
Lecturer, Advisor, Informant
Meeting

Interdisciplinary Networking Trip for Doctoral Students　　　　　　　　　　　　　　　
07 Dec. 2022 - 08 Dec. 2022
Editor, Organizing member
Seminar

COVID-19 & clinical management of mental health issues　　　　　　　　　　　　　　　
Editor, Organizing member
Others
Oxford University

Cerebral Cortex　　　　　　　　　　　　　　　
Sep. 2023 - Present
Peer review
Peer review etc
Oxford Academic

The Journal of Clinical Psychiatry　　　　　　　　　　　　　　　
Aug. 2023 - Present
Peer review
Peer review etc
the American Society of Clinical Psychopharmacology

eNeuro　　　　　　　　　　　　　　　
Present
Peer review
Peer review etc
Society for Neuroscience

BMJ case report　　　　　　　　　　　　　　　
Present
Peer review
Peer review etc
British Medical Journal