2012年08月, XXVIth International Biometric Conference (IBC 2012), Poster Prize; Second Prize　　　　　　　　　　　　　　　
Comparison of risk assessment approaches for adverse drug reactions in the post-marketing study

2011年07月, SASユーザー総会 2011, 最優秀賞　　　　　　　　　　　　　　　
マイクロアレイデータによる予後予測モデル構築における.632+推定量によるエラー率の補正とROC曲線解析

2004年09月, 日本計量生物学会, 奨励賞　　　　　　　　　　　　　　　

Enhancing surgical skills through telesimulation: A multicenter randomized controlled trial on laparoscopic inguinal hernia repair.
Kotoe Kiriyama, Yo Kurashima, Saseem Poudel, Yusuke Watanabe, Yoichi M Ito, Satoshi Hirano
Surgery, 180, 109136, 109136, 2025年01月21日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Telesimulation has been shown to be effective for teaching simple surgical techniques; however, its usefulness for teaching advanced skills remains unclear. The aim of this randomized controlled trial was to investigate the impact of a telesimulation program on training for laparoscopic inguinal hernia repair. METHODS: Novice trainees were randomly assigned to the intervention group or control group using a permuted block design. Intervention group participants received a 1-hour didactic telelecture and three 1-hour telesimulation sessions with a hernia specialist, whereas control group participants engaged in self-directed training using the same simulator and materials. Trainees' procedural videos, recorded before and after training, were assessed using the transabdominal preperitoneal checklist and the Global Operative Assessment of Laparoscopic Skills-Groin Hernia. Pre- and post-training tests were performed to evaluate knowledge of inguinal hernias and self-confidence in transabdominal preperitoneal procedures. RESULTS: Forty-three participants from 16 institutions in Japan were enrolled, with 22 and 19 in the intervention group and control group, respectively, completing the final analysis. Median post-test transabdominal preperitoneal checklist scores were 16 (interquartile range: 15-18.5) in the intervention group and 11 (interquartile range: 8.5-14.5) in the control group; intervention group participants significantly outperformed their counterparts (P < .001). However, comparison of pre- and post-test scores showed skill improvements in both groups (P < .001). Both groups also showed increased knowledge and confidence. CONCLUSION: The telesimulation program effectively enhanced the surgical skills of novice trainees in learning laparoscopic inguinal hernia repair, demonstrating superiority over self-directed learning.

Quantity and quality of napping to mitigate fatigue and sleepiness among nurses working long night shifts: a prospective observational study
Kazuhiro Watanabe, Inaho Shishido, Yoichi M. Ito, Rika Yano
Journal of Physiological Anthropology, 44, 1, Springer Science and Business Media LLC, 2025年01月06日
研究論文（学術雑誌）, Abstract

Background

Napping during night shifts is a countermeasure against fatigue and sleepiness, which both impact patient safety. However, there is insufficient evidence on how nurses nap, especially concerning their napping quality. This study explored night-shift napping and its associated factors among nurses, considering napping quantity and quality, to mitigate fatigue and sleepiness.

Methods

This month-long prospective observational study included 32 nurses working 16-h night shifts in a general ward. All nurses responded to questions on individual factors, while fatigue and sleepiness were checked four times during night shifts. Night-shift napping was measured using a wearable device and classified into six groups: time in bed [TIB] > 180 min and sleep efficiency [SE] ≥ 70%, TIB > 180 min and SE < 70%, TIB 120–180 min and SE ≥ 70%, TIB 120–180 min and SE < 70%, TIB < 120 min and SE ≥ 70%, and TIB < 120 min and SE < 70%.

Results

Most nurses (81.2%) worked four night shifts per month, and 105 night shifts in which nurses intended to nap were analyzed. The two nap conditions (TIB 120–180 min and SE ≥ 70%, TIB > 180 min and SE ≥ 70%) were not worse than other nap conditions in fatigue and sleepiness at the end of the night shift and change in fatigue from the start to the end of the night shift. Sleep reactivity, pre-nap time on electronic devices, and prophylactic naps taken before the night shift were each the common factors related to napping for TIB ≥ 120 min and SE ≥ 70%.

Conclusions

Nurses working long night shifts should consider both sufficient napping quantity and good napping quality. We suggest aiming for a TIB of at least 120 min and a SE of at least 70% to mitigate fatigue and sleepiness at the end of a night shift. Assessing sleep reactivity, pre-nap time on electronic devices, and prophylactic naps may be useful in achieving both quantity and quality effectively. Nurses and their managers should have a better understanding of napping and consider strategically taking naps during night shifts.

Association of Blood Glucose Data With Physiological and Nutritional Data From Dietary Surveys and Wearable Devices: Database Analysis
Takashi Miyakoshi, Yoichi M Ito
JMIR Diabetes, 9, e62831, e62831, JMIR Publications Inc., 2024年12月03日
研究論文（学術雑誌）, Background

Wearable devices can simultaneously collect data on multiple items in real time and are used for disease detection, prediction, diagnosis, and treatment decision-making. Several factors, such as diet and exercise, influence blood glucose levels; however, the relationship between blood glucose and these factors has yet to be evaluated in real practice.

Objective

This study aims to investigate the association of blood glucose data with various physiological index and nutritional values using wearable devices and dietary survey data from PhysioNet, a public database.

Methods

Three analytical methods were used. First, the correlation of each physiological index was calculated and examined to determine whether their mean values or SDs affected the mean value or SD of blood glucose. To investigate the impact of each physiological indicator on blood glucose before and after the time of collection of blood glucose data, lag data were collected, and the correlation coefficient between blood glucose and each physiological indicator was calculated for each physiological index. Second, to examine the relationship between postprandial blood glucose rise and fall and physiological and dietary nutritional assessment indices, multiple regression analysis was performed on the relationship between the slope before and after the peak in postprandial glucose over time and physiological and dietary nutritional indices. Finally, as a supplementary analysis to the multiple regression analysis, a 1-way ANOVA was performed to compare the relationship between the upward and downward slopes of blood glucose and the groups above and below the median for each indicator.

Results

The analysis revealed several indicators of interest: First, the correlation analysis of blood glucose and physiological indices indicated meaningful relationships: acceleration SD (r=–0.190 for lag data at –15-minute values), heart rate SD (r=–0.121 for lag data at –15-minute values), skin temperature SD (r=–0.121), and electrodermal activity SD (r=–0.237) for lag data at –15-minute values. Second, in multiple regression analysis, physiological indices (temperature mean: t=2.52, P=.01; acceleration SD: t=–2.06, P=.04; heart rate_30 SD: t=–2.12, P=.04; electrodermal activity_90 SD: t=1.97, P=.049) and nutritional indices (mean carbohydrate: t=6.53, P<.001; mean dietary fiber: t=–2.51, P=.01; mean sugar: t=–3.72, P<.001) were significant predictors. Finally, the results of the 1-way ANOVA corroborated the findings from the multiple regression analysis.

Conclusions

Similar results were obtained from the 3 analyses, consistent with previous findings, and the relationship between blood glucose, diet, and physiological indices in the real world was examined. Data sharing facilitates the accessibility of wearable data and enables statistical analyses from various angles. This type of research is expected to be more common in the future.

Assessment of factors associated with antipsychotic-induced weight gain: A nationwide cohort study
Shuhei Ishikawa, Naoki Hashimoto, Ryo Okubo, Ryo Sawagashira, Ryodai Yamamura, Yoichi M. Ito, Norihiro Sato, Ichiro Kusumi
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 111231, 111231, Elsevier BV, 2024年12月
研究論文（学術雑誌）

A nomogram to predict skin barrier dysfunction induced by mechanical irritation during skincare in hospitalized Japanese older adults
Issei Konya, Rika Yano, Yoichi M. Ito, Hiroaki Iwata, Mayumi Yoshida, Chiaki Watanabe, Akemi Morita
Geriatric Nursing, Elsevier BV, 2024年11月
研究論文（学術雑誌）

Decision regret after curative treatment and its association with the decision-making process and quality of life for prostate cancer patients.
Miho Sato, Takahiro Osawa, Kentaro Nishioka, Tomohiko Miyazaki, Shuhei Takahashi, Takashi Mori, Takayuki Hashimoto, Haruka Miyata, Ryuji Matsumoto, Takashige Abe, Kazuki Ohashi, Sachiyo Murai, Yoichi M Ito, Nobuo Shinohara
International journal of urology : official journal of the Japanese Urological Association, 2024年10月09日, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVES: To determine how the treatment decision-making process and posttreatment health-related quality of life (HRQOL) are related to regret about treatment choice for prostate cancer patients in Japan. METHODS: We invited a total of 614 patients who were treated with radiation therapy (RT), radical prostatectomy (RP), or active surveillance/watchful waiting (AS/WW) from April 2007 to March 2021. Posttreatment regret was evaluated by the Decision Regret Scale. HRQOL was evaluated by the Expanded Prostate Cancer Index Composite and the 12-item Short Form Survey. The decision-making process was assessed by patient evaluation of the decision-making process. We compared the decision regret scale scores across treatment types, HRQOL, and decision-making processes. RESULTS: Data from 371 patients were analyzed (RT: 202, RP: 149, AS/WW: 20). The median length of time since treatment was 64 (IQR: 43-93) months. The decision regret scale scores were not significantly different among the treatment groups but were significantly greater (strong regret) in patients with poor urinary summary scores, bowel summary scores, and hormonal summary scores. The decision regret scale scores were significantly lower (less regret) for patients who reported being adequately informed at the time of the treatment decision and who had adequately communicated their questions and concerns to physicians than for patients who reported less adequate communication. This result was also observed among patients who reported low HRQOL scores. CONCLUSIONS: These findings underline the important influence of posttreatment HRQOL and decision-making as an interactive process between physicians and their patients on posttreatment regret in prostate cancer patients.

Investigation of interfractional range variation owing to anatomical changes with beam directions based on water equivalent thickness in proton therapy for pancreatic cancer.
Yuhei Kikkawa, Hideaki Ueda, Yusuke Uchinami, Norio Katoh, Hidefumi Aoyama, Yoichi M Ito, Kohei Yokokawa, Ye Chen, Taeko Matsuura, Naoki Miyamoto, Seishin Takao
Journal of radiation research, 2024年10月08日, ［国際誌］
英語, 研究論文（学術雑誌）, To assess the interfractional anatomical range variations (ARVs) with beam directions and their impact on dose distribution in intensity modulated proton therapy, we analyzed water equivalent thickness (WET) from 10 patients with pancreatic cancer. The distributions of the interfractional WET difference ($\Delta{\mathrm{WET } }^{\theta }$) across 360° were visualized using polar histograms. Interfractional ARVs were evaluated using the mean absolute error and ΔWET pass rate, indicating the percentage of $\Delta \mathrm{WE},{\mathrm{T } }^{\theta }$ < thresholds. The impact on dose distribution in proton therapy was evaluated based on two treatment plans for 40 Gy(RBE)/5 fractions: 'Plan A', using two beam angles, in which the target was closest to the body surface among four perpendicular directions; and 'Plan B', using two beam angles with small ARVs. Analysis revealed individual variations in angular trends of interfractional ARVs. Three distinct trends were identified: Group 1 exhibited small ARVs around posterior directions; Group 2 exhibited small ARVs except ~60°; Group 3 demonstrated minimal ARVs only ~90°. In dose evaluation, while 150° and 210° were selected in Plan B for 9 out of 10 patients, for the remaining patient, 60° and 90° were chosen. Comparing dose volume histogram parameters for all patients, Plan B significantly reduced target coverage loss while maintaining organ-at-risk sparing comparable to Plan A. These results demonstrated that selecting beam angles with small interfractional ARVs for each patient enhances the robustness of dose distribution, reducing target coverage loss.

Intravenous infusion of auto-serum-expanded autologous mesenchymal stem cells into chronic severe brain injury patients
Tomohiro Yamaki, Shinichi Oka, Satoshi Iyama, Masanori Sasaki, Rie Onodera, Yuko Kataoka-Sasaki, Takahiro Namioka, Ai Namioka, Masahito Nakazaki, Mitsuhiro Takemura, Ryo Ukai, Takahiro Yokoyama, Yuichi Sasaki, Tatsuro Yamashita, Masato Kobayashi, Misako Yamaguchi, Marina Fukino, Taro Takazawa, Megumi Hayasaka, Takamitsu Owaku, Mika Funakura, Shinji Onodera, Yoichi M. Ito, Masayoshi Kobune, Junji Kato, Sumio Ishiai, Jeffery D. Kocsis, Masaru Odaki, Yasuo Iwadate, Shigeki Kobayashi, Osamu Honmou
Interdisciplinary Neurosurgery: Advanced Techniques and Case Management, 36, 2024年06月
研究論文（学術雑誌）

Cerebral oxygenation saturation in childhood: difference by age and comparison of two cerebral oximetry algorithms.
Yasunori Kubo, Yusuke Itosu, Tomonori Kubo, Hitoshi Saito, Kazufumi Okada, Yoichi M Ito, Yuji Morimoto
Journal of clinical monitoring and computing, 38, 3, 639, 648, 2024年06月, ［国際誌］
英語, 研究論文（学術雑誌）, Few reports are available on the monitoring of regional cerebral oxygen saturation (rSO2) in pediatric patients undergoing non-cardiac surgical procedures. In addition, no study has examined the rSO2 levels in children of a broad age range. In this study, we aimed to assess and compare rSO2 levels in pediatric patients of different age groups undergoing non-cardiac surgery. We used two oximeters, tNIRS-1, which uses time-resolved spectroscopy, and conventional INVOS 5100C. Seventy-eight children-26 infants, 26 toddlers, and 26 schoolchildren-undergoing non-cardiac surgery were included. We investigated the differences in the rSO2 levels among the age groups and the correlation between the models and physiological factors influencing the rSO2 values. rSO2 measured by INVOS 5100C was significantly lower in infants than those in other patients. rSO2 measured by tNIRS-1 was higher in the toddler group than those in the other groups. The rSO2 values of tNIRS-1 and INVOS 5100C were moderately correlated (r = 0.41); however, those of INVOS 5100C were approximately 20% higher, and a ceiling effect was observed. The values in INVOS 5100C and tNIRS-1 were affected by blood pressure and the minimum alveolar concentration of sevoflurane, respectively. In pediatric patients undergoing non-cardiac surgery, rSO2 values differed across the three age groups, and the pattern of these differences varied between the two oximeters employing different algorithms. Further research must be conducted to clarify cerebral oxygenation in children.

A Single-Institution Prospective Study To Evaluate the Safety and Efficacy of Real- Time Image-Gated Spot-Scanning Proton Therapy (RGPT) for Prostate Cancer.
Kentaro Nishioka, Takayuki Hashimoto, Takashi Mori, Yusuke Uchinami, Rumiko Kinoshita, Norio Katoh, Hiroshi Taguchi, Koichi Yasuda, Yoichi M Ito, Seishin Takao, Masaya Tamura, Taeko Matsuura, Shinichi Shimizu, Hiroki Shirato, Hidefumi Aoyama
Advances in radiation oncology, 9, 5, 101464, 101464, 2024年05月, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: In real-time image-gated spot-scanning proton therapy (RGPT), the dose distribution is distorted by gold fiducial markers placed in the prostate. Distortion can be suppressed by using small markers and more than 2 fields, but additional fields may increase the dose to organs at risk. Therefore, we conducted a prospective study to evaluate the safety and short-term clinical outcome of RGPT for prostate cancer. METHODS AND MATERIALS: Based on the previously reported frequency of early adverse events (AE) and the noninferiority margin of 10%, the required number of cases was calculated to be 43 using the one-sample binomial test by the Southwest Oncology Group statistical tools with the one-sided significance level of 2.5% and the power 80%. Patients with localized prostate cancer were enrolled and 3 to 4 pure gold fiducial markers of 1.5-mm diameter were inserted in the prostate. The prescribed dose was 70 Gy(relative biologic effectiveness) in 30 fractions, and treatment was performed with 3 fields from the left, right, and the back, or 4 fields from either side of slightly anterior and posterior oblique fields. The primary endpoint was the frequency of early AE (≥grade 2) and the secondary endpoint was the biochemical relapse-free survival rate and the frequency of late AE. RESULTS: Forty-five cases were enrolled between 2015 and 2017, and all patients completed the treatment protocol. The median follow-up period was 63.0 months. The frequency of early AE (≥grade 2) was observed in 4 cases (8.9%), therefore the noninferiority was verified. The overall 5-year biochemical relapse-free survival rate was 88.9%. As late AE, grade 2 rectal bleeding was observed in 8 cases (17.8%). CONCLUSIONS: The RGPT for prostate cancer with 1.5-mm markers and 3- or 4- fields was as safe as conventional proton therapy in early AE, and its efficacy was comparable with previous studies.

Influence of epicardial adipose tissue inflammation and adipocyte size on postoperative atrial fibrillation in patients after cardiovascular surgery
Hiroyuki Natsui, Masaya Watanabe, Takashi Yokota, Satonori Tsuneta, Yoshizuki Fumoto, Haruka Handa, Matsushima Shouji, Jiro Koya, Kotaro Nishino, Daishiro Tatsuta, Takuya Koizumi, Takahide Kadosaka, Motoki Nakao, Taro Koya, Taro Temma, Yoichi M. Ito, Hatanaka C. Kanako, Yutaka Hatanaka, Shingu Yasushige, Satoru Wakasa, Shuhei Miura, Takahiko Masuda, Naritomo Nishioka, Shuichi Naraoka, Kayoko Ochi, Tomoko Kudo, Tsugumine Ishikawa, Toshihisa Anzai
Physiological Reports, 12, 6, Wiley, 2024年03月28日, ［査読有り］
英語, 研究論文（学術雑誌）, Abstract

Epicardial adipose tissue (EAT) is an active endocrine organ that is closely associated with occurrence of atrial fibrillation (AF). However, the role of EAT in the development of postoperative AF (POAF) remains unclear. We aimed to investigate the association between EAT profile and POAF occurrence in patients who underwent cardiovascular surgery. We obtained EAT samples from 53 patients to evaluate gene expression, histological changes, mitochondrial oxidative phosphorylation (OXPHOS) capacity in the EAT, and protein secretion in EAT‐conditioned medium. EAT volume was measured using computed tomography scan. Eighteen patients (34%) experienced POAF within 7 days after surgery. Although no significant difference was observed in EAT profile between patients with and without POAF, logistic regression analysis identified that the mRNA expression levels of tumor necrosis factor‐alpha (TNF‐α) were positively correlated and adipocyte size in the EAT was inversely correlated with onset of POAF, respectively. Mitochondrial OXPHOS capacity in the EAT was not associated with POAF occurrence; however, it showed an inverse correlation with adipocyte size and a positive correlation with adiponectin secretion. In conclusion, changes in the secretory profile and adipocyte morphology of the EAT, which represent qualitative aspects of the adipose tissue, were present before the onset of AF.

Cross-sectional and longitudinal analyses of urinary extracellular vesicle mRNA markers in urothelial bladder cancer patients.
Taku Murakami, Keita Minami, Toru Harabayashi, Satoru Maruyama, Norikata Takada, Akira Kashiwagi, Haruka Miyata, Yasuyuki Sato, Ryuji Matsumoto, Hiroshi Kikuchi, Takashige Abe, Yoichi M Ito, Sachiyo Murai, Nobuo Shinohara, Hiroshi Harada, Takahiro Osawa
Scientific reports, 14, 1, 6801, 6801, 2024年03月21日, ［国際誌］
英語, 研究論文（学術雑誌）, We designed this multi-center prospective study with the following objectives: (1) the cross-sectional validation of extracellular vesicles (EV) mRNA markers to detect urothelial bladder cancer (UBC) before transurethral resection of bladder cancer (TURBT), and (2) the longitudinal validation of EV mRNA markers to monitor non-muscle invasive bladder cancer (NMIBC) recurrence after TURBT. EV mRNA markers evaluated in this study were KRT17, GPRC5A, and SLC2A1 in addition to two additional markers from literatures, MDK and CXCR2, and measured by quantitative RT-PCR with normalization by a reference gene (ALDOB). Diagnostic performances of EV mRNA markers were compared to conventional markers. Regarding the first objective, we confirmed that EV mRNA biomarkers in urine were higher in UBC patients, particularly those with higher stage/grade tumors, than in those without UBC (n = 278 in total) and the diagnostic performance of EV mRNA MDK and KRT17 outperformed conventional biomarkers with AUC 0.760 and 0.730, respectively. Concerning the second objective, we prospectively analyzed the time courses of EV mRNA markers while NMIBC patients (n = 189) (median follow-up 19 months). The expression of EV mRNA KRT17 was significantly high in patients with recurrence, while it gradually decreased over time in those without recurrence (p < 0.01).

Intracerebral transplantation of MRI-trackable autologous bone marrow stromal cells for patients with subacute ischemic stroke.
Masahito Kawabori, Satoshi Kuroda, Hideo Shichinohe, Kaoru Kahata, Souichi Shiratori, Satoshi Ikeda, Taisuke Harada, Kenji Hirata, Khin Khin Tha, Masato Aragaki, Shunsuke Terasaka, Yoichi M Ito, Naoki Nishimoto, Shunsuke Ohnishi, Ichiro Yabe, Kohsuke Kudo, Kiyohiro Houkin, Miki Fujimura
Med (New York, N.Y.), 2024年03月18日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Ischemic stroke is one of the leading causes of death and neurological disability worldwide, and stem cell therapy is highly expected to reverse the sequelae. This phase 1/2, first-in-human study evaluated the safety, feasibility, and monitoring of an intracerebral-transplanted magnetic resonance imaging (MRI)-trackable autologous bone marrow stromal cell (HUNS001-01) for patients with subacute ischemic stroke. METHODS: The study included adults with severe disability due to ischemic stroke. HUNS001-01 cultured with human platelet lysates and labeled with superparamagnetic iron oxide was stereotactically transplanted into the peri-infarct area 47-64 days after ischemic stroke onset (dose: 2 or 5 × 107 cells). Neurological and radiographic evaluations were performed throughout 1 year after cell transplantation. The trial was registered at UMIN Clinical Trial Registry (number UMIN000026130). FINDINGS: All seven patients who met the inclusion criteria successfully achieved cell expansion, underwent intracerebral transplantation, and completed 1 year of follow-up. No product-related adverse events were observed. The median National Institutes of Health Stroke Scale and modified Rankin scale scores before transplantation were 13 and 4, which showed improvements of 1-8 and 0-2, respectively. Cell tracking proved that the engrafted cells migrated toward the infarction border area 1-6 months after transplantation, and the quantitative susceptibility mapping revealed that cell signals at the migrated area constantly increased throughout the follow-up period up to 34% of that of the initial transplanted site. CONCLUSIONS: Intracerebral transplantation of HUNS001-01 was safe and well tolerated. Cell tracking shed light on the therapeutic mechanisms of intracerebral transplantation. FUNDING: This work was supported by the Japan Agency for Medical Research and Development (AMED; JP17bk0104045 and JP20bk0104011).

Development of a simulator and training curriculum for liver trauma surgery training for general surgeons
Hiroyasu Tojima, Soichi Murakami, Saseem Poudel, Yo Kurashima, Toshimichi Asano, Takehiro Noji, Kazufumi Okada, Yoichi M. Ito, Hiroyuki Kaneko, Yoshimitsu Izawa, Hiroshi Homma, Satoshi Hirano
Global Surgical Education - Journal of the Association for Surgical Education, 3, 1, Springer Science and Business Media LLC, 2024年03月17日
研究論文（学術雑誌）

The Evaluation Study for Social Cognition Measures in Japan: Psychometric properties, relationships with social function, and recommendations
Hisashi Akiyama, Ryo Okubo, Atsuhito Toyomaki, Akane Miyazaki, Sachiko Hattori, Mariko Nohara, Yohei Sasaki, Ryotaro Kubota, Hiroki Okano, Kanami Takahashi, Yumi Hasegawa, Izumi Wada, Takashi Uchino, Kazuyoshi Takeda, Satoru Ikezawa, Takahiro Nemoto, Yoichi M Ito, Naoki Hashimoto
Asian Journal of Psychiatry, 104003, 104003, Elsevier BV, 2024年03月
研究論文（学術雑誌）

Utility of salivary cortisol profile as a predictive biomarker in nurses’ turnover risk: a preliminary study
Shinya Yamaguchi, Tomoko Fujita, Shintaro Kato, Yuichi Yoshimitsu, Yoichi M. Ito, Rika Yano
Journal of Physiological Anthropology, 43, 1, Springer Science and Business Media LLC, 2024年01月02日
研究論文（学術雑誌）, Abstract

Background

Predicting nurse turnover risk is crucial due to the global nursing shortage; however, existing predictors, such as fatigue and burnout, lack objectivity. Salivary cortisol is a non-invasive marker of stress and fatigue, but its utility in predicting nurse turnover risk is unknown. We examined whether salivary cortisol profiles across three different day shifts in a month are predictors of the extent of nurses’ reluctance to stay in their current jobs.

Methods

This preliminary longitudinal study followed forty female nurses who engaged in shift work at a university hospital for 3 months. Data at enrollment were collected including demographics, working conditions, chronic fatigue (the Japanese version of the Occupational Fatigue/Exhaustion Recovery Scale), and burnout (Japanese Burnout scale). Salivary cortisol was measured before the three different day shifts (after awakening) during the first month, and the means of these measurements were used as the cortisol profile. The extent of reluctance to stay was assessed using the numerical rating scale at 3 months.

Results

Among the forty female nurses (mean [SD] age, 28.3 [5.1]), all completed follow-up and were included in the analysis. The cortisol profile was associated with the extent of reluctance to stay (P = 0.017), and this association was significant despite adjustments for chronic fatigue and burnout (P = 0.005). A multiple regression model with chronic fatigue, burnout, and job tenure explained 41.5% of the variation in reluctance to stay. When the cortisol profile was added to this model, the association of the cortisol profile was significant (P = 0.006) with an R² of 0.529 (ΔR² = 0.114).

Conclusions

This preliminary study conducted in an actual clinical setting indicated the potential of the salivary cortisol profile across three different day shifts in a month to predict nurses’ reluctance to stay in their current jobs. The combination of subjective indicators and the cortisol profile would be useful in predicting nurses' turnover risk.

Eribulin for patients with metastatic extramammary Paget disease: Study protocol for a single-arm phase II trial.
Takuya Maeda, Teruki Yanagi, Keiko Tokuchi, Takeru Funakoshi, Nao Horie, Toshiyuki Isoe, Yoichi M Ito, Norihiro Sato, Hideyuki Ujiie
Experimental dermatology, 33, 1, e14993, 2024年01月, ［国際誌］
英語, 研究論文（学術雑誌）, Extramammary Paget disease (EMPD) is a rare cutaneous malignancy that predominantly affects the anogenital areas of the elderly. Although the efficacy of docetaxel and other cytotoxic agents for advanced EMPD has been reported in small retrospective case studies, no treatment has been proven effective in prospective clinical trials. We established the world's first in vivo EMPD experimental model (a patient-derived xenograft model). In our treatment experiment, xenograft tumours showed a remarkable response to eribulin. This study evaluates the efficacy of eribulin for patients with advanced EMPD. In October 2022, we started a single-arm phase II trial to evaluate the efficacy of eribulin as a treatment for adult patients with unresectable EMPD with measurable lesions. Enrolment in this clinical trial is open to patients with any prior treatment for EMPD. The primary endpoint is overall response rate; the secondary endpoints include disease control rate, overall survival, progression-free survival and adverse events. The study protocol was approved by the Ethics Committee of Hokkaido University and the other collaborating institutions. If the primary endpoint is met, it is our hope that eribulin will be regarded as a standard medication for patients with advanced EMPD.

Risk factors for abnormal glucose metabolism during antipsychotic treatment: A prospective cohort study.
Takashi Miyakoshi, Shuhei Ishikawa, Ryo Okubo, Naoki Hashimoto, Norihiro Sato, Ichiro Kusumi, Yoichi M Ito
Journal of psychiatric research, 168, 149, 156, 2023年10月27日, ［国際誌］
英語, 研究論文（学術雑誌）, Antipsychotic medications increase the risk of abnormal glucose metabolism. However, in clinical practice, it is difficult to predict this risk because it is affected by medication-related and background factors. This study aimed to identify the risk factors for abnormal glucose metabolism during antipsychotic treatment. We conducted a multicenter, prospective, cohort study in patients with schizophrenia, schizoaffective disorder, or bipolar disorder. Of these patients, those with prediabetes or possible diabetes were excluded. Finally, 706 patients were included in the analysis. The hazard ratio (HR) for each factor was calculated for events of progression to hyperglycemia using time-dependent Cox regression analysis stratified according to facility type and adjusted for available background and drug-related factors. Treatments with olanzapine (HR = 2.06, 95% confidence interval [CI] = 1.05-4.05), clozapine (HR = 4.25, 95% CI = 1.56-11.60), and chlorpromazine (HR = 4.48, 95% CI = 1.21-16.57), overweight and obesity (HR = 1.57, 95% CI = 1.02-2.41), and hypertriglyceridemia (HR = 1.72, 95% CI = 1.02-2.88) were associated with a significantly higher occurrence of hyperglycemic progression. The number and daily dose of antipsychotics were not associated with their occurrence. Our study demonstrated that more careful monitoring is necessary during olanzapine, clozapine, and chlorpromazine treatment because of the higher occurrence of abnormalities in glucose metabolism. Furthermore, patients with obesity or hypertriglyceridemia warrant monitoring for the occurrence of abnormal glucose metabolism, regardless of the type of antipsychotic medication.

Inverse association between glucose variability and body fat in type 2 diabetes with impaired endogenous insulin secretion assessed using continuous glucose monitoring: A prospective observational study.
Aika Miya, Akinobu Nakamura, Yuka Suzuki, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, Yoichi M Ito, So Nagai, Hideaki Miyoshi, Tatsuya Atsumi
Diabetes, obesity & metabolism, 25, 7, 1883, 1889, 2023年07月, ［国際誌］
英語, 研究論文（学術雑誌）, AIM: To evaluate the contribution of body fat mass and serum adiponectin concentration to glucose variability (GV) stability in people with type 2 diabetes with impaired versus preserved endogenous insulin secretion. MATERIALS AND METHODS: This multicentre prospective observational study included 193 people with type 2 diabetes who underwent ambulatory continuous glucose monitoring, abdominal computed tomography and fasting blood sampling. A fasting C-peptide (FCP) concentration >2 ng/mL was defined as preserved endogenous insulin secretion. The participants were divided into high (FCP > 2 ng/mL) and low FCP subgroups (FCP ≤ 2 ng/mL). Multivariate regression analysis was performed in each subgroup. RESULTS: In the high FCP subgroup, the coefficient of variation (CV) in GV was unrelated to abdominal fat area. In the low FCP subgroup, a high CV was significantly related to small abdominal visceral fat area (β = -0.11, standard error 0.03; P < 0.05) and to small subcutaneous fat area (β = -0.09, standard error 0.04; P < 0.05). No significant relationship between serum adiponectin concentration and continuous glucose monitoring-related variables was found. CONCLUSIONS: The contribution of body fat mass to GV depends on the endogenous insulin secretion residue. A small body fat area has independent adverse effects on GV in people with type 2 diabetes and impaired endogenous insulin secretion.

Associations of COVID-19 symptoms with omicron subvariants BA.2 and BA.5, host status, and clinical outcomes in Japan: a registry-based observational study.
Sho Nakakubo, Naoki Kishida, Kenichi Okuda, Keisuke Kamada, Masami Iwama, Masaru Suzuki, Isao Yokota, Yoichi M Ito, Yasuyuki Nasuhara, Richard C Boucher, Satoshi Konno
The Lancet. Infectious diseases, 2023年06月30日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Previous SARS-CoV-2 infection and vaccination, coupled with the rapid evolution of SARS-CoV-2 variants, have modified COVID-19 clinical manifestations. We aimed to characterise the clinical symptoms of COVID-19 individuals in omicron BA.2 and BA.5 Japanese pandemic periods to identify omicron and subvariant associations between symptoms, immune status, and clinical outcomes. METHODS: In this registry-based observational study, individuals registered in Sapporo's web-based COVID-19 information system entered 12 pre-selected symptoms, days since symptom onset, vaccination history, SARS-CoV-2 infection history, and background. Eligibility criteria included symptomatic individuals who tested positive for SARS-CoV-2 (PCR or antigen test), and individuals who were not tested for SARS-CoV-2 but developed new symptoms after a household member tested positive for SARS-CoV-2. Symptom prevalence, variables associated with symptoms, and symptoms associated with progression to severe disease were analysed. FINDINGS: Data were collected and analysed between April 25 and Sept 25, 2022. For 157 861 omicron-infected symptomatic individuals, cough was the most common symptom (99 032 [62·7%] patients), followed by sore throat (95 838 [60·7%] patients), nasal discharge (69 968 [44·3%] patients), and fever (61 218 [38·8%] patients). Omicron BA.5 infection was associated with a higher prevalence of systemic symptoms than BA.2 in vaccinated and unvaccinated individuals (adjusted odds ratio [OR] for fever: 2·18 [95% CI 2·12-2·25]). Omicron breakthrough-infected individuals with three or more vaccinations or previous infection were less likely to exhibit systemic symptoms (fever 0·50 [0·49-0·51]), but more likely to exhibit upper respiratory symptoms (sore throat 1·33 [1·29-1·36]; nasal discharge 1·84 [1·80-1·89]). Infected older individuals (≥65 years) had lower odds for all symptoms. However, when symptoms were manifest, systemic symptoms were associated with increased odds for severe disease (dyspnoea 3·01 [1·84-4·91]; fever 2·93 [1·89-4·52]), whereas upper respiratory symptoms were associated with decreased odds (sore throat 0·38 [0·24-0·63]; nasal discharge 0·48 [0·28-0·81]). INTERPRETATION: Host immunological status, omicron subvariant, and age were associated with a spectrum of COVID-19 symptoms and outcomes. BA.5 produced a higher systemic symptom prevalence than BA.2. Vaccination and previous infection reduced systemic symptom prevalence and improved outcomes but increased upper respiratory tract symptom prevalence. Systemic, but not upper respiratory, symptoms in older people heralded severe disease. Our findings could serve as a practical guide to use COVID-19 symptoms to appropriately modify health-care strategies and predict clinical outcomes for older patients with omicron infections. FUNDING: Japan Agency for Medical Research and Development.

Five-Year Stroke Risk and Its Predictors in Asymptomatic Moyamoya Disease: Asymptomatic Moyamoya Registry (AMORE).
Satoshi Kuroda, Shusuke Yamamoto, Takeshi Funaki, Miki Fujimura, Hiroharu Kataoka, Tomohito Hishikawa, Jun Takahashi, Hidenori Endo, Tadashi Nariai, Toshiaki Osato, Nobuhito Saito, Norihiro Sato, Emiko Hori, Yoichi M Ito, Susumu Miyamoto
Stroke, 54, 6, 1494, 1504, 2023年06月, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Long-term outcomes are unknown in patients with asymptomatic moyamoya disease. In this report, we aimed to clarify their 5-year risk of stroke and its predictors. METHODS: We are conducting a multicenter, prospective cohort study (Asymptomatic Moyamoya Registry) in Japan. Participants were eligible if they were 20 to 70 years, had bilateral or unilateral moyamoya disease, experienced no episodes suggestive of TIA and stroke; and were functionally independent (modified Rankin Scale score 0-1). Demographic and radiological information was collected at enrollment. In this study, they are still followed up for 10 years. In this interim analysis, we defined the primary end point as a stroke occurring during a 5-year follow-up period. Independent predictors for stroke were also determined, using a stratification analysis method. RESULTS: Between 2012 and 2015, we enrolled 109 patients, of whom 103 patients with 182 involved hemispheres completed the 5-year follow-up. According to the findings on DSA and MRA, 143 hemispheres were judged as moyamoya disease and 39 hemispheres as questionable manifestations (isolated middle cerebral artery stenosis). The patients with questionable hemispheres were significantly older, more often male, and more frequently had hypertension than those with moyamoya hemisphere. Moyamoya hemispheres developed 7 strokes, including 6 hemorrhagic and 1 ischemic stroke, during the first 5 years. The annual risk of stroke was 1.4% per person, 0.8% per hemisphere, and 1.0% per moyamoya hemisphere. Independent predictor for stroke was Grade-2 choroidal anastomosis (hazard ratio, 5.05 [95% CI, 1.24-20.6]; P=0.023). Furthermore, microbleeds (hazard ratio, 4.89 [95% CI, 1.13-21.3]; P=0.0342) and Grade-2 choroidal anastomosis (hazard ratio, 7.05 [95% CI, 1.62-30.7]; P=0.0093) significantly predicted hemorrhagic stroke. No questionable hemispheres developed any stroke. CONCLUSIONS: The hemispheres with asymptomatic moyamoya disease may carry a 1.0% annual risk of stroke during the first 5 years, the majority of which are hemorrhagic stroke. Grade-2 choroidal anastomosis may predict stroke, and the microbleeds and Grade-2 choroidal anastomosis may carry the risk for hemorrhagic stroke. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: UMIN000006640.

Proton beam therapy for gliomas: a multicenter prospective registry study from all proton beam facilities in Japan
Takashi Mori, Masashi Mizumoto, Katsuya Maebayashi, Kentaro Nishioka, Yoshiki Arakawa, Kazuhiko Kurozumi, Koichi Yasuda, Taisuke Sumiya, Hiroyasu Tamamura, Yoshitaka Sato, Takahiro Waki, Masaru Takagi, Yu Takada, Tomoaki Okimoto, Masao Murakami, Yasuhiro Kikuchi, Kazufumi Okada, Yoichi M Ito, Tetsuo Akimoto, Hidefumi Aoyama
Journal of Radiation Research, Oxford University Press (OUP), 2023年04月07日
研究論文（学術雑誌）, Abstract

We reviewed the outcomes of glioma patients enrolled in a prospective observational registry study of proton beam therapy (PBT) in Japan. The inclusion criteria were glioma patients registered in the Electronic Data Capture system, the Proton-net, between May 2016 and July 2019. Data on patient characteristics, treatments, late adverse events, survival status, recurrence and secondary tumors were extracted and statistically analyzed. The primary endpoint was the overall survival (OS) rate, and the secondary endpoints were the progression-free survival (PFS) rate and cumulative local recurrence rate (cLRR). Of the 65 primary brain tumor patients registered, 29 glioma patients from eight of 19 PBT facilities met the inclusion criteria. There were 19 glioblastoma patients, eight of other malignant gliomas, and two of low-grade gliomas. For glioblastomas, with a median follow-up period of 16 months, the median survival time was 21.2 months and the OS at 1, 2, 3 and 4 years were 77.4%, 44.9%, 23.9% and 23.9%, respectively. The median PFS period was 10.1 months, the 1, 2, 3 and 4-year PFS were 32.4%, 19.4%, 9.7% and 9.7%, respectively. The 1, 2, 3 and 4-year cLRR were 56.1%, 68.8%, 78.4 and 78.4%, respectively. Grade 3 brain necrosis was observed in two patients. No secondary tumor was observed. This is the first report on the current status of PBT for gliomas in Japan. For glioblastomas, the outcomes of PBT are estimated to be equivalent to historical data of photon therapy. The results of a prospective comparative evaluation of PBT and photon therapy are awaited.

Development and validation of the Care Transitions Scale for Patients with Heart Failure: A tool for nurses to assess patients' readiness for hospital discharge
Mai Yoshimura, Masumi Kawamura, Satoko Hasegawa, Yoichi M. Ito, Keita Takahashi, Naomi Sumi
Japan Journal of Nursing Science, Wiley, 2023年02月08日
研究論文（学術雑誌）

Associations of COVID-19 Symptoms with Omicron Subvariants BA.2 and BA.5, Host Status, and Clinical Outcomes: A Registry-Based Observational Study in Sapporo, Japan.
Sho Nakakubo, Naoki Kishida, Kenichi Okuda, Keisuke Kamada, Masami Iwama, Masaru Suzuki, Isao Yokota, Yoichi M Ito, Yasuyuki Nasuhara, Richard C Boucher, Satoshi Konno
medRxiv : the preprint server for health sciences, 2023年02月07日, ［国際誌］
英語, BACKGROUND: Previous SARS-CoV-2 infection and vaccination, coupled to rapid evolution of SARS-CoV-2 variants, have modified COVID-19 clinical manifestations. We characterized clinical symptoms of COVID-19 individuals in omicron BA.2 and BA.5 Japanese pandemic periods to identify omicron and subvariant associations between symptoms, immune status, and clinical outcomes. METHODS: Individuals registered in Sapporo's web-based COVID-19 information system entered 12 pre-selected symptoms, days since symptom onset, vaccination history, SARS-CoV-2 infection history, and background. Symptom frequencies, variables associated with symptoms, and symptoms associated with progression to severe disease were analysed. RESULTS: For all omicron-infected individuals, cough was the most common symptom (62.7%), followed by sore throat (60.7%), nasal discharge (44.3%), and fever (38.8%). Omicron BA.5 infection was associated with a higher symptom burden than BA.2 in vaccinated and unvaccinated individuals. Omicron breakthrough-infected individuals with ≥ 3 vaccinations or previous infection were less likely to exhibit systemic symptoms, but more likely to exhibit upper respiratory symptoms. Infected elderly individuals had lower odds for all symptoms, but, when symptoms were manifest, systemic symptoms were associated with an increased risk, whereas upper respiratory symptoms with a decreased risk, of severe disease. CONCLUSION: Host immunological status, omicron subvariant, and age were associated with a spectrum of COVID-19 symptoms and outcomes. BA.5 produced a greater symptom burden than BA.2. Vaccination and prior infection mitigated systemic symptoms and improved outcomes, but increased upper respiratory tract symptom burden. Systemic, but not upper respiratory, symptoms in the elderly heralded severe disease.

Protocol for treating lumbar spinal canal stenosis with a combination of ultrapurified, allogenic bone marrow-derived mesenchymal stem cells and in situ-forming gel: a multicentre, prospective, double-blind randomised controlled trial.
Hideki Sudo, Takashi Miyakoshi, Yudai Watanabe, Yoichi M Ito, Kaoru Kahata, Khin Khin Tha, Nozomi Yokota, Hiroe Kato, Tomoko Terada, Norimasa Iwasaki, Teruyo Arato, Norihiro Sato, Toshiyuki Isoe
BMJ open, 13, 2, e065476, 2023年02月02日, ［国際誌］
英語, 研究論文（学術雑誌）, INTRODUCTION: In patients with combined lumbar spinal canal stenosis (LSCS), a herniated intervertebral disc (IVD) that compresses the dura mater and nerve roots is surgically treated with discectomy after laminoplasty. However, defects in the IVD after discectomy may lead to inadequate tissue healing and predispose patients to the development of IVD degeneration. Ultrapurified stem cells (rapidly expanding clones (RECs)), combined with an in situ-forming bioresorbable gel (dMD-001), have been developed to fill IVD defects and prevent IVD degeneration after discectomy. We aim to investigate the safety and efficacy of a new treatment method in which a combination of REC and dMD-001 is implanted into the IVD of patients with combined LSCS. METHODS AND ANALYSIS: This is a multicentre, prospective, double-blind randomised controlled trial. Forty-five participants aged 20-75 years diagnosed with combined LSCS will be assessed for eligibility. After performing laminoplasty and discectomy, participants will be randomised 1:1:1 into the combination of REC and dMD-001 (REC-dMD-001) group, the dMD-001 group or the laminoplasty and discectomy alone (control) group. The primary outcomes of the trial will be the safety and effectiveness of the procedure. The effectiveness will be assessed using visual analogue scale scores of back pain and leg pain as well as MRI-based estimations of morphological and compositional quality of the IVD tissue. Secondary outcomes will include self-assessed clinical scores and other MRI-based estimations of compositional quality of the IVD tissue. All evaluations will be performed at baseline and at 1, 4, 12, 24 and 48 weeks after surgery. ETHICS AND DISSEMINATION: This study was approved by the ethics committees of the institutions involved. We plan to conduct dissemination of the outcome data by presenting our data at national and international conferences, as well as through formal publication in a peer-reviewed journal. TRIAL REGISTRATION NUMBER: jRCT2013210076.

肝細胞癌陽子線治療効果予測におけるADC値指標の検討　　　　　　　　　　　　　　　
藤田 祥博, 加藤 徳雄, 打浪 雄介, 田口 大志, 西岡 健太郎, 森 崇, 安田 耕一, 小泉 富基, 大塚 愛美, 高尾 聖心, 田村 昌也, Sutherland Kenneth, Khin Khin Tha, 伊藤 陽一, 青山 英史
Japanese Journal of Radiology, 41, Suppl., 10, 10, (公社)日本医学放射線学会, 2023年02月
日本語

Change in cerebral circulation during the induction of anesthesia with remimazolam.
Takashi Soejima, Kentaro Ueda, Sakae Hasegawa, Hiromitsu Motoe, Kazufumi Okada, Yoichi M Ito, Koji Hoshino, Yuji Morimoto
Journal of anesthesia, 37, 1, 92, 96, 2023年02月, ［国内誌］
英語, 研究論文（学術雑誌）, PURPOSE: Remimazolam is a new ultra-short-acting benzodiazepine with unknown effects on cerebral circulation. We measured total cerebral hemoglobin concentrations, which reflect cerebral blood volume (CBV), and cerebral oxygen saturation, using time-domain near-infrared spectroscopy, which can measure the absolute values of cerebral hemoglobin concentrations. We also measured cerebral blood flow velocity (CBFV) in the middle cerebral artery using transcranial Doppler as an indicator of cerebral blood flow (CBF). We did so to examine the effect of remimazolam on cerebral circulation in humans, as assessed CBV, CBF, and cerebral oxygen saturation. METHODS: This was a prospective, observational study. Fifteen patients without serious complications scheduled for general anesthesia were recruited. We measured total cerebral hemoglobin concentrations, CBFV, and cerebral oxygen saturation throughout the anesthetic induction course with remimazolam. RESULTS: Total cerebral hemoglobin concentrations did not change during the process (p = 0.51). In contrast, the mean CBFV was reduced by 11% (significant, p = 0.04). The drop in mean blood pressure following the induction of anesthesia was 17%; however, it was within the range of cerebrovascular autoregulation. Moreover, cerebral oxygen saturation increased by 4% (statistically significant, p < 0.01). CONCLUSIONS: We found that anesthetic induction with remimazolam did not alter CBV and reduced CBF in uncomplicated patients.

Distribution of human papilloma virus genotypes and treatment outcomes in definitive radiotherapy for cervical cancer.
Rumiko Kinoshita, Takashi Mitamura, Fumi Kato, Takahiro Hattori, Hajime Higaki, Shuhei Takahashi, Yoshihiro Fujita, Manami Otsuka, Fuki Koizumi, Yusuke Uchinami, Takashi Mori, Kentaro Nishioka, Takayuki Hashimoto, Yoichi M Ito, Hidemichi Watari, Hidefumi Aoyama
Journal of radiation research, 64, 2, 463, 470, 2023年01月03日, ［国際誌］
英語, 研究論文（学術雑誌）, Most oncogenic human papilloma virus (HPV) genotypes stratify into two species, α-7 HPV and α-9 HPV. There are several studies that evaluate the relationship between HPV species and treatment outcomes and reports that HPV species is prognostic. The HPV genotyping was conducted using biopsy specimens which had been stored in these studies. We conducted the study using the HPV test performed by cytology specimens which is less invasive and more useful in clinical settings. This study enrolled 46 patients who received HPV genotyping before the definitive radiotherapy. The results of the HPV genotyping were classified into HPVα-7, HPVα-9 and negatives. Of the 46 patients, 10 were positive for HPVα-7, 21 positive for HPVα-9 and 15 were negative. The median follow-up period was 38 months (range 4-142). The HPVα-7, HPVα-9 and negative groups showed the 3-year overall survival (OS; 59.3%, 80.4% and 72.2% [P = 0.25]); local control (LC; 67.5%, 81% and 80% [P = 0.78]); pelvic control (PC) (50%, 81% and 72.7% [P = 0.032]); pelvic lymph node (PLN) control (78.7%, 95% and 92.3% [P = 0.012]); distant metastasis free (DMF) survival (50%, 75.4% and 42.8% [P = 0.098]); and progression free survival (PFS) rate of patients (30%, 66.7% and 38.9% [P = 0.085]), respectively. Patients with HPVα-7 showed statistically significant poorer PC than the HPVα-9 group, in multivariate analysis. This result is consistent with previous studies for HPV positive patients. The HPV negativity rate was higher in this study than in other studies and further work on this may be needed for clinical use.

Relationships of computed tomography-based small vessel indices of the lungs with ventilation heterogeneity and high transfer coefficients in non-smokers with asthma.
Kaoruko Shimizu, Hirokazu Kimura, Naoya Tanabe, Shotaro Chubachi, Susumu Sato, Masaru Suzuki, Kazuya Tanimura, Hiroaki Iijima, Akira Oguma, Yoichi M Ito, Nobuyasu Wakazono, Michiko Takimoto-Sato, Machiko Matsumoto-Sasaki, Yuki Abe, Nozomu Takei, Hironi Makita, Masaharu Nishimura, Satoshi Konno
Frontiers in physiology, 14, 1137603, 1137603, 2023年, ［国際誌］
英語, 研究論文（学術雑誌）, Background: The mechanism of high transfer coefficients of the lungs for carbon monoxide (Kco) in non-smokers with asthma is explained by the redistribution of blood flow to the area with preserved ventilation, to match the ventilation perfusion. Objectives: To examine whether ventilation heterogeneity, assessed by pulmonary function tests, is associated with computed tomography (CT)-based vascular indices and Kco in patients with asthma. Methods: Participants were enrolled from the Hokkaido-based Investigative Cohort Analysis for Refractory Asthma (Hi-CARAT) study that included a prospective asthmatic cohort. Pulmonary function tests including Kco, using single breath methods; total lung capacity (TLC), using multiple breath methods; and CT, were performed on the same day. The ratio of the lung volume assessed using single breath methods (alveolar volume; VA) to that using multiple breath methods (TLC) was calculated as an index of ventilation heterogeneity. The volume of the pulmonary small vessels <5 mm2 in the whole lung (BV5 volume), and number of BV5 at a theoretical surface area of the lungs from the plural surface (BV5 number) were evaluated using chest CT images. Results: The low VA/TLC group (the lowest quartile) had significantly lower BV5 number, BV5 volume, higher BV5 volume/BV5 number, and higher Kco compared to the high VA/TLC group (the highest quartile) in 117 non-smokers, but not in 67 smokers. Multivariable analysis showed that low VA/TLC was associated with low BV5 number, after adjusting for age, sex, weight, lung volume on CT, and CT emphysema index in non-smokers (not in smokers). Conclusion: Ventilation heterogeneity may be associated with low BV5 number and high Kco in non-smokers (not in smokers). Future studies need to determine the dynamic regional system in ventilation, perfusion, and diffusion in asthma.

Validation of the Japanese version of the Body Image Scale for bladder cancer patients.
Miho Sato, Takahiro Osawa, Takashige Abe, Michitaka Honda, Madoka Higuchi, Shuhei Yamada, Jun Furumido, Hiroshi Kikuchi, Ryuji Matsumoto, Yasuyuki Sato, Yoshihiro Sasaki, Toru Harabayashi, Satoru Maruyama, Norikata Takada, Keita Minami, Hiroshi Tanaka, Ken Morita, Akira Kashiwagi, Sachiyo Murai, Yoichi M Ito, Katsuhiko Ogasawara, Nobuo Shinohara
Scientific reports, 12, 1, 21544, 21544, 2022年12月13日, ［国際誌］
英語, 研究論文（学術雑誌）, The Body Image Scale (BIS) is a 10-item tool that measures the body images of cancer patients. This study aims to validate the Japanese version of the BIS for bladder cancer patients. A multicenter cross-sectional survey was used to identify the participants, which included Japanese bladder cancer patients. The percentage of missing responses, internal consistency, and known-group validity were evaluated. The correlations between the BIS and two HRQOL instruments (the Bladder Cancer Index and the SF-12) were assessed to determine convergent validity. Among 397 patients, 221 patients were treated by transurethral resection of bladder tumor (TURBT) endoscopically, 49 patients underwent cystectomy with neobladder, and 127 patients underwent cystectomy involving stoma. The percentage of missing responses in the BIS ranged from 8.1 to 15.6%. Cronbach's α coefficient was 0.924. Higher BIS scores indicate negative body image, and the median BIS score for patients with native bladders after TURBT (0.5) was significantly lower than those of the patients with neobladder (4.0) and stoma formation (7.0), which indicated the discriminatory ability of the BIS. Each domain of the Bladder Cancer Index and the role summary score of the SF-12 correlated to the BIS scores, which confirmed the convergent validity. A range of BIS scores were identified among patients who reported similar physical summary scores and mental summary scores of the SF-12. This study confirmed the reliability and validity of the Japanese version of the BIS for bladder cancer patients.

Changes in Cerebral Hemodynamics During Systemic Pulmonary Shunt and Pulmonary Artery Banding in Infants with Congenital Heart Disease.
Yoshifumi Takeda, Masataka Yamamoto, Koji Hoshino, Yoichi M Ito, Nobuyasu Kato, Satoru Wakasa, Yuji Morimoto
Pediatric cardiology, 2022年09月01日, ［国際誌］
英語, 研究論文（学術雑誌）, Palliative surgery is often performed in the treatment of congenital heart disease. Two representative palliative procedures are the systemic pulmonary shunt and pulmonary artery banding. Dramatic changes in cerebral hemodynamics may occur in these operations due to changes in the pulmonary-to-systemic blood flow ratio and systemic oxygenation. However, there seem to be almost no studies evaluating them. Accordingly, we evaluated cerebral perfusion by transcranial Doppler ultrasonography and cerebral oxygenation by near infrared spectroscopy during these procedures. In the post hoc analysis of a previous prospective observational study, cerebral blood flow velocities of the middle cerebral artery measured by transcranial Doppler were compared between the start and end of surgery as were the pulsatility index and resistance index. The cerebral oxygenation values were also compared between the start and end of surgery. Twenty-two infants with systemic pulmonary shunt and 20 infants with pulmonary artery banding were evaluated. There were no significant differences of the flow velocities between the start and end of surgery in either procedure. The pulsatility index significantly increased after pulmonary artery banding, which may compete with the increase in cerebral perfusion due to the increase in systemic blood flow. The cerebral oxygenation decreased in both procedures, possibly due to an increase in body temperature. Arterial oxygen saturation was almost the same before and after both procedures. Contrary to our expectation, the changes in cerebral hemodynamics in the palliative operations were small if the management of physiological indices such as arterial oxygen saturation was properly performed during the procedures.

Phase II Study of Ramucirumab Plus Irinotecan Combination Therapy as Second-Line Treatment in Patients with Advanced Gastric Cancer: HGCSG1603.
Yasuyuki Kawamoto, Satoshi Yuki, Kentaro Sawada, Michio Nakamura, Osamu Muto, Susumu Sogabe, Yoshiaki Shindo, Atsushi Ishiguro, Atsushi Sato, Yasushi Tsuji, Masayoshi Dazai, Hiroyuki Okuda, Takashi Meguro, Kazuaki Harada, Mari Sekiguchi, Kazufumi Okada, Yoichi M Ito, Yuh Sakata, Naoya Sakamoto, Yoshito Komatsu
The oncologist, 27, 8, e642-e649, 2022年08月05日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Ramucirumab is a human IgG1 monoclonal vascular endothelial growth factor receptor-2 antibody that inhibits tumor cell growth and affects the tumor cell microenvironment. We assessed the efficacy and safety of ramucirumab plus irinotecan combination therapy as second-line treatment in patients with previously treated advanced gastric cancer. MATERIALS AND METHODS: Patients with advanced gastric cancer refractory or intolerant to primary chemotherapy were included. Ramucirumab 8 mg/kg plus irinotecan 150 mg/m2 combination therapy was administered every 2 weeks. The primary endpoint was progression-free survival rate at 6 months and secondary endpoints were overall survival, progression-free survival, response rate, safety, and dose intensity for each drug. RESULTS: Thirty-five patients were enrolled between January 2018 and September 2019. The progression-free survival rate at 6 months was 26.5% [95%CI, 13.2%-41.8%, P = .1353)]. Median progression-free and overall survivals were 4.2 months (95%CI, 2.5-5.4 months) and 9.6 months (95%CI, 6.4-16.6 months), respectively. The overall response rate was 25.9% (95%CI, 11.1-36.3%) and disease control rate was 85.2% (95%CI, 66.3-95.8%). Grade ≥3 adverse events that occurred in >10% of patients included neutropenia, leucopenia, anemia, anorexia, and febrile neutropenia. No death or new safety signals with a causal relation to the study treatment were observed. CONCLUSION: Although the primary endpoint was not achieved statistically, combination therapy of ramucirumab plus irinotecan showed anticancer activity and a manageable safety profile for second-line treatment of patients with advanced gastric cancer.

Salivary Biomarker Profiles and Chronic Fatigue among Nurses Working Rotation Shifts: An Exploratory Pilot Study
Shinya Yamaguchi, Kazuhiro Watanabe, Naotaka Sugimura, Inaho Shishido, Issei Konya, Tomoko Fujita, Yuichi Yoshimitsu, Shintaro Kato, Yoichi M. Ito, Rika Yano
HEALTHCARE, 10, 8, 2022年08月
英語, 研究論文（学術雑誌）

Salivary Biomarker Profiles and Chronic Fatigue among Nurses Working Rotation Shifts: An Exploratory Pilot Study.
Shinya Yamaguchi, Kazuhiro Watanabe, Naotaka Sugimura, Inaho Shishido, Issei Konya, Tomoko Fujita, Yuichi Yoshimitsu, Shintaro Kato, Yoichi M Ito, Rika Yano
Healthcare (Basel, Switzerland), 10, 8, 2022年07月28日, ［国際誌］
英語, 研究論文（学術雑誌）, Although nurses' fatigue affects their well-being and patient safety, no effective objective measurements exist. We explored the profiles of salivary biomarkers associated with nurses' chronic fatigue across several shifts. This longitudinal study involved 45 shiftwork nurses and collected their saliva samples before two night and two day shifts for a month. Chronic fatigue was measured using the Cumulative Fatigue Symptom Index before the first night shift. Biomarker profiles were analyzed using hierarchical cluster analysis, and chronic fatigue levels were compared between the profiles. Cortisol profiles were classified into high- and low-level groups across two day shifts; the low-level group presented significantly higher irritability and unwillingness to work. Secretory immunoglobulin A (s-IgA) profiles across the four shifts were classified into high- and low-level groups; the high-level group had significantly higher depressive feelings, decreased vitality, irritability, and unwillingness to work. Cortisol (two day shifts) and s-IgA (four shifts) profiles were combined, and (i) cortisol low-level and s-IgA high-level and (ii) cortisol high-level and s-IgA low-level groups were identified. The former group had significantly higher chronic fatigue sign and irritability than the latter group. The profiles of salivary cortisol and s-IgA across several shifts were associated with nurses' chronic fatigue.

Intravenous Infusion of Autoserum-Expanded Autologous Mesenchymal Stem Cells in Patients With Chronic Brain Injury: Protocol for a Phase 2 Trial
Shinichi Oka, Tomohiro Yamaki, Masanori Sasaki, Ryo Ukai, Mitsuhiro Takemura, Takahiro Yokoyama, Yuko Kataoka-Sasaki, Rie Onodera, Yoichi M Ito, Shigeki Kobayashi, Jeffery D Kocsis, Yasuo Iwadate, Osamu Honmou
JMIR Research Protocols, 11, 7, e37898, e37898, JMIR Publications Inc., 2022年07月06日
研究論文（学術雑誌）, Background

Brain injuries resulting from motor vehicle accidents and falls, as well as hypoxic insults and other conditions, are one of the leading causes of disability and death in the world. Current treatments are limited but include continuous rehabilitation, especially for chronic brain injury. Recent studies have demonstrated that the intravenous infusion of mesenchymal stem cells (MSCs) has therapeutic efficacy for several neurological diseases, including stroke and spinal cord injury.

Objective

The objective of our investigator-initiated clinical trial is to assess the safety and potential efficacy of the intravenous infusion of autoserum-expanded autologous MSCs for patients with chronic brain injury.

Methods

The (phase 2) trial will be a single-arm, open-label trial with the primary objective of confirming the safety and efficacy of autoserum-expanded autologous MSCs (STR-01; produced under good manufacturing practices) when administered to patients with chronic brain injury. The estimated number of enrolled participants is 6 to 20 patients with a modified Rankin Scale grade of 3 to 5. The assessment of safety and the proportion of cases in which the modified Rankin Scale grade improves by 1 point or more at 180 days after the injection of STR-01 will be performed after MSC infusion.

Results

We received approval for our clinical trial from the Japanese Pharmaceuticals and Medical Devices Agency on December 12, 2017. The trial will be completed on June 11, 2023. The registration term is 5 years. The recruitment of the patients for this trial started on April 20, 2018, at Sapporo Medical University Hospital in Japan.

Conclusions

Our phase 2 study will aim to address the safety and efficacy of the intravenous infusion of MSCs for patients with chronic brain injury. The use of STR-01 has been performed for patients with cerebral infarction and spinal cord injury, providing encouraging results. The potential therapeutic efficacy of the systemic administration of autoserum-expanded autologous MSCs for chronic brain injury should be evaluated, given its safety and promising results for stroke and spinal cord injury.

Trial Registration

Japan Medical Association Center for Clinical Trials JMA-IIA00333; https://tinyurl.com/nzkdfnbc

International Registered Report Identifier (IRRID)

DERR1-10.2196/37898

Effects of obesity on CC16 and their potential role in overweight/obese asthma.
Houman Goudarzi, Hirokazu Kimura, Hiroki Kimura, Hironi Makita, Munehiro Matsumoto, Nozomu Takei, Kaoruko Shimizu, Masaru Suzuki, Taku Watanabe, Eiki Kikuchi, Hiroshi Ohira, Ichizo Tsujino, Jun Sakakibara-Konishi, Naofumi Shinagawa, Noriharu Shijubo, Hirokazu Sato, Katsunori Shigehara, Kichizo Kaga, Yasuhiro Hida, Soichi Murakami, Yuma Ebihara, Akinobu Nakamura, Hideaki Miyoshi, Satoshi Hirano, Nobuyuki Hizawa, Tatsuya Atsumi, Shau-Ku Huang, Yoichi M Ito, Masaharu Nishimura, Satoshi Konno
Respiratory research, 23, 1, 174, 174, 2022年06月29日, ［国際誌］
英語, 研究論文（学術雑誌）, INTRODUCTION: Club cell secretory protein-16 (CC16) is a major anti-inflammatory protein expressed in the airway; however, the potential role of CC16 on overweight/obese asthma has not been assessed. In this study, we examined whether obesity reduces airway/circulatory CC16 levels using experimental and epidemiological studies. Then, we explored the mediatory role of CC16 in the relationship of overweight/obesity with clinical asthma measures. METHODS: Circulating CC16 levels were assessed by ELISA in three independent human populations, including two groups of healthy and general populations and asthma patients. The percentage of cells expressing club markers in obese vs. non-obese mice and human airways was determined by immunohistochemistry. A causal mediation analysis was conducted to determine whether circulatory CC16 acted as a mediator between overweight/obesity and clinical asthma measures. RESULTS: BMI was significantly and monotonously associated with reduced circulating CC16 levels in all populations. The percentage of CC16-expressing cells was reduced in the small airways of both mice and humans with obesity. Finally, mediation analysis revealed significant contributions of circulatory CC16 in the association between BMI and clinical asthma measures; 21.8% of its total effect in BMI's association with airway hyperresponsiveness of healthy subjects (p = 0.09), 26.4% with asthma severity (p = 0.030), and 23% with the required dose of inhaled corticosteroid (p = 0.042). In logistic regression analysis, 1-SD decrease in serum CC16 levels of asthma patients was associated with 87% increased odds for high dose ICS requirement (p < 0.001). CONCLUSIONS: We demonstrate that airway/circulating CC16, which is inversely associated with BMI, may mediate development and severity in overweight/obese asthma.

HOPS-R01 phase II trial evaluating neoadjuvant S-1 therapy for resectable pancreatic adenocarcinoma.
Toru Nakamura, Tsuyoshi Hayashi, Yasutoshi Kimura, Hiroshi Kawakami, Kuniyuki Takahashi, Hirotoshi Ishiwatari, Takuma Goto, Masayo Motoya, Keisuke Yamakita, Yusuke Sakuhara, Michihiro Ono, Eiichi Tanaka, Makoto Omi, Katsuhiko Murakawa, Tomoya Iida, Tamaki Sakurai, Shin Haba, Takehiro Abiko, Yoichi M Ito, Hiroyuki Maguchi, Satoshi Hirano
Scientific reports, 12, 1, 9966, 9966, 2022年06月15日, ［国際誌］
英語, 研究論文（学術雑誌）, Although neoadjuvant therapy (Nac) is recommended for high-risk resectable pancreatic cancer (R-PDAC), evidence regarding specific regimes is scarce. This report aimed to investigate the efficacy of S-1 Nac for R-PDAC. In a multicenter phase II trial, we investigated the efficacy of Nac S-1 (an oral fluoropyrimidine agent containing tegafur, gimeracil, and oteracil potassium) in R-PDAC patients. The protocol involved two cycles of preoperative S-1 chemotherapy, followed by surgery, and four cycles of postoperative S-1 chemotherapy. Two-year progression-free survival (PFS) rates were the primary endpoint. Overall survival (OS) rates and median survival time (MST) were secondary endpoints. Forty-nine patients were eligible, and 31 patients underwent resection following Nac, as per protocol (31/49; 63.3%). Per-protocol analysis included data from 31 patients, yielding the 2-year PFS rate of 58.1%, and 2-, 3-, and 5-year OS rates of 96.8%, 54.8%, and 44.0%, respectively. MST was 49.2 months. Intention-to-treat analysis involved 49 patients, yielding the 2-year PFS rate of 40.8%, and the 2-, 3-, and 5-year OS rates of 87.8%, 46.9%, and 33.9%, respectively. MST was 35.5 months. S-1 single regimen might be an option for Nac in R-PDAC; however, the high drop-out rate (36.7%) was a limitation of this study.

Frequency-Response Relationship Between Exercise and Locomotive Syndrome Across Age Groups: Secondary Analysis of a Nationwide Cross-Sectional Study in Japan.
Satoshi Yamaguchi, Keiko Yamada, Yoichi M Ito, Takeshi Fuji, Kimihito Sato, Takashi Ohe
Modern rheumatology, 33, 3, 617, 622, 2022年06月11日, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVES: This study aimed to clarify the frequency-response relationship between exercise habits and locomotive syndrome in different age groups. METHODS: We analyzed 8,681 independent community dwellers who participated in a nationwide cross-sectional locomotive syndrome study. Participants were divided into young (20-39 years), middle (40-64 years), and old (≥ 65 years) groups. The presence of locomotive syndrome was evaluated using the locomotive syndrome risk tests. Exercise habits were assessed by exercise frequency (almost every day/sometimes/occasionally/never). The association between locomotive syndrome and exercise was assessed using the multiple logistic regression analysis adjusted for participant characteristics for each age category. RESULTS: Overall, 3,528 (41%) participants had locomotive syndrome. In the old group, the risk of locomotive syndrome was lower with an increased exercise frequency. However, this dose-response relationship was not found in the young group. The proportion of locomotive syndrome was lower even in participants who occasionally exercised (1-3 days/month) than those who never exercise in the young and middle age groups. CONCLUSIONS: Regular exercise reduced the risk of locomotive syndrome not only in middle and older adults but also in young adults. Moreover, increasing exercise frequency may provide benefits for locomotive syndrome prevention, especially among older adults.

Phase II study of niraparib in recurrent or persistent rare fraction of gynecologic malignancies with homologous recombination deficiency (JGOG2052).
Hiroshi Asano, Katsutoshi Oda, Kosuke Yoshihara, Yoichi M Ito, Noriomi Matsumura, Muneaki Shimada, Hidemichi Watari, Takayuki Enomoto
Journal of gynecologic oncology, 33, 4, e55, 2022年05月03日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Poly (adenosine diphosphate)-ribose polymerase (PARP) inhibitors for tumors with homologous recombination deficiency (HRD), including pathogenic mutations in BRCA1/2, have been developed. Genomic analysis revealed that about 20% of uterine leiomyosarcoma (uLMS) have HRD, including 7.5%-10% of BRCA1/2 alterations and 4%-6% of carcinomas of the uterine corpus, and 2.5%-4% of the uterine cervix have alterations of BRCA1/2. Preclinical and clinical case reports suggest that PARP inhibitors may be effective against those targets. The Japanese Gynecologic Oncology Group (JGOG) is now planning to conduct a new investigator-initiated clinical trial, JGOG2052. METHODS: JGOG2052 is a single-arm, open-label, multi-center, phase 2 clinical trial to evaluate the efficacy and safety of niraparib monotherapy for a recurrent or persistent rare fraction of gynecologic malignancies with BRCA1/2 mutations except for ovarian cancers. We will independently consider the effect of niraparib for uLMS or other gynecologic malignancies with BRCA1/2 mutations (cohort A, C) and HRD positive uLMS without BRCA1/2 mutations (cohort B). Participants must have 1-3 lines of previous chemotherapy and at least one measurable lesion according to RECIST (v.1.1). Niraparib will be orally administered once a day until lesion exacerbation or unacceptable adverse events occur. Efficacy will be evaluated by imaging through an additional computed tomography scan every 8 weeks. Safety will be measured weekly in cycle 1 and every 4 weeks after cycle 2 by blood tests and physical examinations. The sample size is 16-20 in each of cohort A and B, and 31 in cohort C. Primary endpoint is the objective response rate. TRIAL REGISTRATION: Japan Primary Registries Network (JPRN) Identifier: jRCT2031210264.

Disease activity as a risk factor for venous thromboembolism in rheumatoid arthritis analysed using time-averaged DAS28CRP: a nested case-control study.
Masaru Yoshimura, Yuichiro Fujieda, Masanari Sugawara, Michihito Kono, Masaru Kato, Isao Yokota, Olga Amengual, Yoichi M Ito, Tatsuya Atsumi
Rheumatology international, 42, 11, 1939, 1946, 2022年04月06日, ［国際誌］
英語, 研究論文（学術雑誌）, The objective of this study is to clarify the clinical features and risk factors of venous thromboembolism (VTE) in patients with rheumatoid arthritis (RA). We retrospectively reviewed the prevalence of VTE in RA patients who visited Hokkaido University Hospital from 2010 to 2019 and had more than 2 years of follow-up. To explore the risk to develop VTE, we selected 260 RA patients without VTE (non-VTE) via density sampling and identified the risk factors for VTE by multivariate logistic regression analysis. Univariate conditional logistic regression analysis showed older age (p < 0.0001, Odds Ratio [OR] 1.08, 95% Confidence Interval [CI] 1.04-1.14), increase of the body mass index (BMI) (p = 0.001, OR 1.17, 95% CI 1.06-1.31), higher prevalence of RA-associated lung disease (p = 0.002, OR 2.10, 95% CI 1.33-3.30) and more frequent glucocorticoid usage (p = 0.001, OR 2.09, 95% CI 1.34-3.51) in RA patients was associated with the development of VTE significantly. Furthermore, patients with higher time-averaged disease activity score 28 (DAS28) CRP were at elevated risk (p < 0.0001, OR 3.25, 95% CI 1.94-6.12). In conditional multivariate logistic regression analysis, time averaged DAS28CRP was significantly associated with the development of VTE (p = 0.0001, adjusted OR 3.40, 95% CI 1.77-7.85). Disease activity was identified as a major risk factor of VTE in patients with RA, suggesting that sustained clinical remission could be beneficial for decrease the risk of VTE.

難治性喘息 重症喘息における生物学的製剤の変更に影響する因子の検討
佐々木 真知子, 清水 薫子, 鈴木 正宣, 鈴木 雅, 松本 宗大, 木村 孔一, 中丸 裕爾, 伊藤 陽一, 今野 哲
日本呼吸器学会誌, 11, 増刊, 143, 143, (一社)日本呼吸器学会, 2022年04月
日本語

Subthreshold Change in Glycated Hemoglobin and Body Mass Index After the Initiation of Second-Generation Antipsychotics Among Patients With Schizophrenia or Bipolar Disorder
Ryo Sawagashira, Ryodai Yamamura, Ryo Okubo, Naoki Hashimoto, Shuhei Ishikawa, Yoichi M. Ito, Norihiro Sato, Ichiro Kusumi
The Journal of Clinical Psychiatry, 83, 3, Physicians Postgraduate Press, Inc, 2022年03月30日
研究論文（学術雑誌）

The type rather than the daily dose or number of antipsychotics affects the incidence of hyperglycemic progression
Shuhei Ishikawa, Ryodai Yamamura, Naoki Hashimoto, Ryo Okubo, Ryo Sawagashira, Yoichi M. Ito, Norihiro Sato, Ichiro Kusumi
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 113, 110453, 110453, Elsevier BV, 2022年03月
研究論文（学術雑誌）

Dosimetric advantages of daily adaptive strategy in IMPT for high-risk prostate cancer.
Hiroshi Tamura, Keiji Kobashi, Kentaro Nishioka, Takaaki Yoshimura, Takayuki Hashimoto, Shinichi Shimizu, Yoichi M Ito, Yoshikazu Maeda, Makoto Sasaki, Kazutaka Yamamoto, Hiroyasu Tamamura, Hidefumi Aoyama, Hiroki Shirato
Journal of applied clinical medical physics, 23, 4, e13531, 2022年01月19日, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: To evaluate the dosimetric advantages of daily adaptive radiotherapy (DART) in intensity-modulated proton therapy (IMPT) for high-risk prostate cancer by comparing estimated doses of the conventional non-adaptive radiotherapy (NART) that irradiates according to an original treatment plan through the entire treatment and the DART that uses an adaptive treatment plan generated by using daily CT images acquired before each treatment. METHODS: Twenty-three patients with prostate cancer were included. A treatment plan with 63 Gy (relative biological effectiveness (RBE)) in 21 fractions was generated using treatment planning computed tomography (CT) images assuming that all patients had high-risk prostate cancer for which the clinical target volume (CTV) needs to include prostate and the seminal vesicle (SV) in our treatment protocol. Twenty-one adaptive treatment plans for each patient (total 483 data sets) were generated using daily CT images, and dose distributions were calculated. Using a 3 mm set-up uncertainty in the robust optimization, the doses to the CTV, prostate, SV, rectum, and bladder were compared. RESULTS: Estimated accumulated doses of NART and DART in the 23 patients were 60.81 ± 3.47 Gy (RBE) and 63.24 ± 1.04 Gy (RBE) for CTV D99 (p < 0.01), 62.99 ± 1.28 Gy (RBE) and 63.43 ± 1.33 Gy (RBE) for the prostate D99 (p = 0.2529), and 59.07 ± 5.19 Gy (RBE) and 63.17 ± 1.04 Gy (RBE) for SV D99 (p < 0.001). No significant differences were observed between NART and DART in the estimated accumulated dose for the rectum and bladder. CONCLUSION: Compared with the NART, DART was shown to be a useful approach that can maintain the dose coverage to the target without increasing the dose to the organs at risk (OAR) using the 3 mm set-up uncertainty in the robust optimization in patients with high-risk prostate cancer.

Psychometric properties of the Japanese version of the Occupational Fatigue Exhaustion Recovery Scale among shift-work nurses.
Shinya Yamaguchi, Miho Sato, Naomi Sumi, Yoichi M Ito, Peter C Winwood, Rika Yano
Journal of occupational health, 64, 1, e12325, 2022年01月, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVES: Shift-work nurses are at a higher risk of inadequate recovery from fatigue and developing maladaptive fatigue with significant health consequences. Therefore, it is necessary to monitor fatigue and recovery levels with a reliable scale. We investigated psychometric properties of the Japanese version of the Occupational Fatigue Exhaustion Recovery scale (OFER-J) for shift-work nurses. METHODS: Japanese shift-work nurses responded to self-administered questionnaires at baseline (n = 942) and one month later (n = 334). The confirmatory factor analysis (CFA) and exploratory factor analysis (EFA) were conducted to verify the structural validity and the correlation analysis and one-way analysis of variance were conducted to test the construct and discriminative validity. Cronbach's alpha coefficient, intra-class correlation coefficient (ICC), and smallest detectable change (SDC) were calculated to assess reliability. RESULTS: The CFA showed high correlations between the factors and whilst the goodness-of-fit of the three-factor model was suboptimal, it was in an acceptable range. Most modifications included the error covariance of the Acute Fatigue (AF) and Intershift Recovery (IR) items. The EFA showed that Chronic Fatigue (CF) and AF were not clearly separated, indicating that the two AF items dropped out. Construct and discriminative validity were also well indicated. Cronbach's alpha coefficients were 0.75-0.85. Only CF showed sufficient reproductivity (ICC = 0.74). The SDC for CF, AF, and IR was 14.0, 17.1, and 18.7, respectively. CONCLUSIONS: The validity and reliability of the OFER-J were verified as acceptable for shift-work nurses. The OFER-J could contribute to a data-based approach to fatigue management in nursing management practice.

Clinical Characteristics of Patients and Factors Associated with Switching Biologics in Asthma.
Machiko Matsumoto-Sasaki, Kaoruko Simizu, Masanobu Suzuki, Masaru Suzuki, Hirokazu Kimura, Yuji Nakamaru, Yoichi M Ito, Akihiro Honma, Satoshi Konno
Journal of asthma and allergy, 15, 187, 195, 2022年, ［国際誌］
英語, 研究論文（学術雑誌）, Purpose: Biologics have been used increasingly for the treatment of severe asthma. However, established guidelines for the selection, switching, or discontinuation of biologics do not exist. We aimed to identify the clinical characteristics of patients with asthma who required switching biologics and the factors associated with switching biologics. Patients and Methods: This was a retrospective study of 42 patients with severe asthma treated with biologics at the Hokkaido University Hospital between 23rd June 2016 and 30th April 2021, when two biologics were available in Japan. We compared the characteristics of subjects who continued and switched biologics. The time to switch the biologics was assessed by type 2 inflammatory biomarkers, pulmonary function indices, and the presence of comorbidities, including the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) score and aspirin exacerbated respiratory diseases (AERD), using the Kaplan-Meier method and a multivariate Cox proportional hazards model. Results: Eight and five patients were treated by mepolizumab and benralizumab at baseline, respectively among the 31% (13/42) who switched the biologics. Subjects who required switching biologics were characterized by high blood eosinophil counts, younger age, JESREC scores of 11 points or higher, and AERD. The time taken to switch biologics was significantly shorter in the subgroups with high JESREC scores (≥11) or AERD, compared with their counterparts with low JESREC scores or without AERD (both, P < 0.05). JESREC scores of ≥11, but not the presence of AERD, were associated with time to switch biologics. Conclusion: The presence of eosinophilic chronic rhinosinusitis based on JESREC scores of ≥11 and younger age were factors associated with switching biologics in asthma.

Factors associated with mobility decrease leading to disability: a cross-sectional nationwide study in Japan, with results from 8681 adults aged 20-89 years.
Keiko Yamada, Satoshi Yamaguchi, Yoichi M Ito, Takashi Ohe
BMC geriatrics, 21, 1, 651, 651, 2021年11月19日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Mobility decrease leading to disability can gradually develop during early life, however, its related factors are not well clarified. Therefore, we investigate the related factors of mobility decrease at various levels, using nationwide data in Japan. METHODS: In total, 8681 independent community dwellers aged 20-89 years were analysed (average age, 51.6 years; 58.5% women). Three stages of mobility decrease were based on the locomotive syndrome risk test: Stage 1, emerging; Stage 2, progressing; Stage 3, progressed to restrict social engagement. Age was analysed using a simple quadratic function model. RESULTS: The prevalence of Stages 1-3 was 31.6% (n = 2746), 5.8% (n = 504), and 3.2% (n = 278), respectively. On the multivariable logistic regression, increased age in participants aged ≥40 years (stage 1: odds ratio[OR] 1.05-1.20, stage 2: OR 1.04-1.22, stage 3: OR 1.05-1.22), female (stage 1: OR 2.28, 95% confidence interval [CI] 1.99-2.61, stage 2: OR 2.40, 95% CI 1.77-3.25, stage 3: OR 1.80, 95% CI 1.19-2.72), overweight status (stage 1: OR 1.56, 95% CI 1.34-1.82, stage 2: OR 3.19, 95% CI 2.38-4.27, stage 3: OR 2.87, 95% CI 1.90-4.32), hypertension (stage 1: OR 1.20, 95% CI 1.01-1.41, stage 2: OR 1.99, 95% CI 1.49-2.64, stage 3: OR 2.10, 95% CI 1.44-3.05), and diabetes mellitus (stage 1: OR 1.62, 95% CI 1.17-2.24, stage 2: OR 1.57, 95% CI 0.93-2.66, stage 3: OR 2.10, 95% CI 1.13-3.90) were positively associated. The frequency of physical activity/sports, even a few per month, was inversely associated with all stages (stage 1: OR 0.59-0.72, stage 2: OR 0.50-0.67, stage 3: 0.36-0.53). A one-year increase in age had a stronger impact on mobility decrease in older adults than in younger ones. Increased age in participants aged < 40 years and smoking were associated with Stage 1, while intake of various foods was inversely associated with Stages 1 and 2. CONCLUSION: Increased age (< 40 years) was associated with emerging mobility decrease, while that (≥ 40 years) was associated with any levels of mobility decrease. Female, lifestyle habits, including physical activities and overweight status, were associated with mobility decrease at every level.

Particle therapy using protons or carbon ions for cancer patients with cardiac implantable electronic devices (CIED): a retrospective multi-institutional study.
Takayuki Hashimoto, Yusuke Demizu, Haruko Numajiri, Tomonori Isobe, Shigekazu Fukuda, Masaru Wakatsuki, Haruo Yamashita, Shigeyuki Murayama, Shigeyuki Takamatsu, Hiroyuki Katoh, Kazutoshi Murata, Ryosuke Kohno, Takeshi Arimura, Taeko Matsuura, Yoichi M Ito
Japanese journal of radiology, 40, 5, 525, 533, 2021年11月15日, ［国内誌］
英語, 研究論文（学術雑誌）, PURPOSE: To evaluate the outcomes of particle therapy in cancer patients with cardiac implantable electronic devices (CIEDs). MATERIALS AND METHODS: From April 2001 to March 2013, 19,585 patients were treated with proton beam therapy (PBT) or carbon ion therapy (CIT) at 8 institutions. Of these, 69 patients (0.4%, PBT 46, CIT 22, and PBT + CIT 1) with CIEDs (64 pacemakers, 4 implantable cardioverter defibrillators, and 1 with a cardiac resynchronization therapy defibrillator) were retrospectively reviewed. All the patients with CIEDs in this study were treated with the passive scattering type of particle beam therapy. RESULTS: Six (13%) of the 47 PBT patients, and none of the 23 CIT patients experienced CIED malfunctions (p = 0.105). Electrical resets (7) and over-sensing (3) occurred transiently in 6 patients. The distance between the edge of the irradiation field and the CIED was not associated with the incidence of malfunctions in 20 patients with lung cancer. A larger field size had a higher event rate but the test to evaluate trends as not statistically significant (p = 0.196). CONCLUSION: Differences in the frequency of occurrence of device malfunctions for patients treated with PBT and patients treated with CIT did not reach statistical significance. The present study can be regarded as a benchmark study about the incidence of malfunctioning of CIED in passive scattering particle beam therapy and can be used as a reference for active scanning particle beam therapy.

Development and validation of a prediction model based on the organ-based metabolic tumor volume on FDG-PET in patients with differentiated thyroid carcinoma.
Yuko Uchiyama, Kenji Hirata, Shiro Watanabe, Shozo Okamoto, Tohru Shiga, Kazufumi Okada, Yoichi M Ito, Kohsuke Kudo
Annals of nuclear medicine, 35, 11, 1223, 1231, 2021年11月, ［国内誌］
英語, 研究論文（学術雑誌）

がん治療医・緩和ケアスタッフを対象としたターミナルケア態度尺度を用いた意識調査　　　　　　　　　　　　　　　
熊井 正貴, 加藤 信太郎, 小柳 遼, 敦賀 健吉, 伊藤 陽一, 山田 武宏, 川本 泰之, 武隈 洋, 菅原 満, 小松 嘉人
Palliative Care Research, 16, Suppl._Hokkaido, S492, S492, (NPO)日本緩和医療学会, 2021年10月
日本語

Determination of brain tumor recurrence using 11 C-methionine positron emission tomography after radiotherapy.
Shigeru Yamaguchi, Kenji Hirata, Michinari Okamoto, Eku Shimosegawa, Jun Hatazawa, Ryuichi Hirayama, Naoki Kagawa, Haruhiko Kishima, Noboru Oriuchi, Masazumi Fujii, Kentaro Kobayashi, Hiroyuki Kobayashi, Shunsuke Terasaka, Ken-Ichi Nishijima, Yuji Kuge, Yoichi M Ito, Hiroshi Nishihara, Nagara Tamaki, Tohru Shiga
Cancer science, 112, 10, 4246, 4256, 2021年10月, ［国際誌］
英語, 研究論文（学術雑誌）

Developing a questionnaire on the quality of working life for female medical and healthcare professionals.
Kikuko Taketomi, Yoichi M Ito, Eriko Tokunaga, Yuko O Hirano, Yuriko Fujino, Akiko Chishaki
Industrial health, 59, 6, 371, 382, 2021年09月28日, ［国内誌］
英語, 研究論文（学術雑誌）, This study aimed to develop a questionnaire on the quality of working life among female medical and healthcare professionals and examine its validity and reliability. The questionnaire was developed from an item pool drawing on the literature. The four trait scales included 40 items, covering female-specific stress in continuing a career, stress of lifestyle in maintaining personal values, job satisfaction and social support network. The questionnaire's validity and reliability were assessed using data from 1,784 female doctors, dentists, and nurses. Validity was examined using exploratory factor analysis on each trait for construct validity, and multitrait scaling analysis for convergent and discriminant validity. Reliability was tested using Cronbach's alpha for trait subscales and scales. Exploratory factor analysis on each trait was convergent. One trait derived three subscales, and another two. The remaining two traits were convergent for one factor. Multitrait scaling analysis showed that all scales and subscales were independent. The questionnaire was therefore internally consistent and had construct validity. Cronbach's alpha was 0.85 for the total and between 0.72 and 0.83 for the subscales. These results validate the four-trait combination questionnaire and suggest that it would be suitable for use in future research, perhaps in combination with other existing scales.

Elevated serum CYFRA 21-1 level as a diagnostic marker for thymic carcinoma.
Haruhiko Shiiya, Hideki Ujiie, Yasuhiro Hida, Tatsuya Kato, Kichizo Kaga, Satoru Wakasa, Eiki Kikuchi, Naofumi Shinagawa, Kazufumi Okada, Yoichi M Ito, Yoshihiro Matsuno
Thoracic cancer, 12, 21, 2933, 2942, 2021年09月27日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: No useful tumor markers have been identified for the diagnosis of thymic carcinomas. Serum cytokeratin 19 fragment, measured using the CYFRA 21-1 immunoassay, is used as a tumor marker for squamous cell carcinomas in various malignant tumors. Here, we evaluated the value of CYFRA 21-1 in diagnosing thymic carcinoma. METHODS: We retrospectively reviewed 94 patients with pathological diagnoses of thymic carcinoma or thymoma (32 and 62 patients, respectively) who were referred to our departments between January 2000 and March 2019. Primary outcomes included tumor marker levels and their diagnostic accuracy. RESULTS: Patients with thymic carcinoma were significantly more likely to be male (thymic carcinoma, 68.8%; thymoma, 40.3%; p = 0.02), have an advanced TNM stage (p < 0.01), and a significantly higher CYFRA 21-1 level than those with thymoma (thymic carcinoma: median = 4.2 ng/ml; interquartile range [IQR] = 2.1-6.1 ng/ml vs. thymoma: median = 1.2 ng/ml; IQR = 0.9-1.7 ng/ml; p < 0.01). Receiver operating characteristic curves demonstrated that the area under the curve for CYFRA 21-1 to distinguish thymic carcinoma from thymoma was 0.86 (95% confidence interval [CI]: 0.74-0.93; cutoff = 2.7 ng/ml; sensitivity = 68.8%; specificity = 95.2%). Multivariable analysis demonstrated that CYFRA 21-1 (odds ratio = 25.6; 95% CI: 4.6-141.6; p < 0.01) was an independent predictor for thymic carcinoma after adjusting for TNM stage. CONCLUSIONS: Serum CYFRA 21-1 level may help in diagnosing thymic carcinoma.

Association of abdominal visceral adiposity with sputum IL-5 levels in asthma.
Houman Goudarzi, Hirokazu Kimura, Hironi Makita, Yuki Abe, Akira Oguma, Michiko Sato, Munehiro Matsumoto, Nozomu Takei, Hiroki Kimura, Kaoruko Shimizu, Masaru Suzuki, Yoichi M Ito, Masaharu Nishimura, Satoshi Konno
Allergology international : official journal of the Japanese Society of Allergology, 71, 1, 137, 139, 2021年09月14日, ［国際誌］
英語

Thrombocytopenia Associated with Unrecognized Non-Alcoholic Fatty Liver Disease Is an Independent Predictor of Perioperative Significant Blood Loss in Cervical Laminoplasty.
Ryota Suzuki, Yoshinao Koike, Masahiro Ota, Tsutomu Endo, Yuichiro Hisada, Takeru Tsujimoto, Masahiro Kanayama, Yoichi M Ito, Hideki Sudo, Akira Iwata, Katsuhisa Yamada, Norimasa Iwasaki, Masahiko Takahata
World neurosurgery, 155, e797-e804, 2021年09月09日, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVE: To identify risk factors for significant blood loss (SBL) in cervical laminoplasty, especially regarding thrombocytopenia and coagulopathy resulting from non-alcoholic fatty liver disease (NAFLD). METHODS: We retrospectively investigated differences in patient background data, laboratory data at the time of admission, and surgery-related data of 317 patients who underwent cervical laminoplasty and were divided into SBL (estimated blood loss [EBL] + drainage [D] ≥500 g) and non-SBL (EBL + D < 500 g) groups. To evaluate liver status, we used the fibrous 4 index and considered fibrous 4 index ≥1.85 as a representative phenotype for NAFLD with liver fibrosis. In addition, the risk factor for perioperative SBL was investigated using multiple logistic regression analysis, and the cutoff value was calculated. RESULTS: Incidence of perioperative SBL in cervical laminoplasty was 7.3% (23/317). Compared with the non-SBL group, the SBL group demonstrated significantly lower platelet count (PLT), lower aspartate aminotransferase, longer operation time, and greater number of opened laminae. According to multivariate analysis, lower PLT and a greater number of opened laminae were identified as significant risk factors for perioperative SBL. The cutoff value of PLT for predicting SBL was determined to be 16.7 × 104/μL using a receiver operating characteristic curve. The liver fibrosis group revealed significantly lower PLT and greater EBL + D than the non-liver fibrosis group. CONCLUSIONS: Thrombocytopenia is an independent predictor of perioperative SBL in cervical laminoplasty. Thus, patients with mild thrombocytopenia that may be associated with NAFLD must be carefully monitored to avoid perioperative SBL.

Work environment for hospital nurses in Japan: The relationships between nurses' perceptions of their work environment and nursing outcomes.
Yasuko Ogata, Kana Sato, Yoshimi Kodama, Noriko Morioka, Kikuko Taketomi, Yuki Yonekura, Kimiko Katsuyama, Sachiko Tanaka, Midori Nagano, Yoichi M Ito, Katsuya Kanda
Nursing open, 8, 5, 2470, 2487, 2021年09月, ［国際誌］
英語, 研究論文（学術雑誌）

Exploratory clinical trial on the safety and capability of dMD-001 in lumbar disc herniation: Study protocol for a first-in-human pilot study.
Katsuhisa Yamada, Maeda Kenichiro, Yoichi M Ito, Fujio Inage, Toshiyuki Isoe, Nozomi Yokota, Osamu Sugita, Norihiro Sato, Khin Khin Tha, Norimasa Iwasaki, Teruyo Arato, Hideki Sudo
Contemporary clinical trials communications, 23, 100805, 100805, 2021年09月, ［国際誌］
英語, 研究論文（学術雑誌）, Herniated nucleus pulposus (NP), one of the most common diseases of the spine, is surgically treated by removing the sequestered NP. However, intervertebral disc (IVD) defects may remain after discectomy, leading to inadequate tissue healing and predisposing patients to IVD degeneration. An acellular, bioresorbable, ultra-purified alginate (UPAL) gel (dMD-001) implantation system can be used to fill any IVD defects in order to prevent IVD degeneration after discectomy. This first-in-human pilot study aims to determine the feasibility, safety, and perceived patient response to a combined treatment involving discectomy and UPAL gel implantation for herniated NP. We designed a one-arm, double-centre, open-label, pilot trial. The study started in November 2018 and will run until a sample of 40 suitable participants is established. Patients aged 20-49 years, diagnosed with isolated lumbar IVD herniation and scheduled for discectomy represent suitable candidates. All eligible participants who provide informed consent undergo standard discectomy followed by UPAL gel implantation. The primary outcomes of the trial will be the feasibility and safety of the procedure. Secondary outcomes will include self-assessed clinical scores and magnetic resonance imaging-based measures of morphological and compositional quality of the IVD tissue. Initial outcomes will be published at 24 weeks. Analysis of feasibility and safety will be performed using descriptive statistics. Both intention-to-treat and per-protocol analyses of treatment trends of effectiveness will be conducted.

Close association between non-alcoholic fatty liver disease and ossification of the posterior longitudinal ligament of the spine.
Tsutomu Endo, Yoshinao Koike, Hideaki Miyoshi, Yuichiro Hisada, Ryo Fujita, Ryota Suzuki, Masaru Tanaka, Takeru Tsujimoto, Yukitoshi Shimamura, Yuichi Hasegawa, Masahiro Kanayama, Tomoyuki Hashimoto, Fumihiro Oha, Naoki Noro, Kiyofumi Komano, Misaki Ishii, Yoichi M Ito, Norimasa Iwasaki, Masahiko Takahata
Scientific reports, 11, 1, 17412, 17412, 2021年08月31日, ［国際誌］
英語, 研究論文（学術雑誌）

Three-day regimen of oseltamivir for post-exposure prophylaxis of influenza in hospital wards: a study protocol for a prospective, multi-center, single-arm trial.
Nobuhisa Ishiguro, Yoichi M Ito, Sumio Iwasaki, Miki Nagao, Hideki Kawamura, Shinichiro Kanai, Yoko Nukui, Koichi Tokuda, Takayuki Miyara, Hidetoshi Igari, Koichi Yamada, Hiroki Chikumi, Chiaki Sano, Ryuji Koike, Tetsuya Yagi, Nobuo Murakami
BMC infectious diseases, 21, 1, 887, 887, 2021年08月30日, ［国際誌］
英語, 研究論文（学術雑誌）

Efficacy and safety of second-line axitinib in octogenarians with metastatic renal cell carcinoma.
Yasutomo Nakai, Ario Takeuchi, Takahiro Osawa, Takahiro Kojima, Tomohiko Hara, Mikio Sugimoto, Masatoshi Eto, Keita Minami, Kosuke Ueda, Michinobu Ozawa, Motohide Uemura, Yasuyuki Miyauchi, Kojiro Ohba, Akira Kashiwagi, Masaya Murakami, Tomokazu Sazuka, Hiroaki Yasumoto, Shuichi Morizane, Yoshihide Kawasaki, Daichi Morooka, Toru Shimazui, Yoshiaki Yamamoto, Hiroshi Nakagomi, Ryotaro Tomida, Yoichi M Ito, Sachiyo Murai, Hiroshi Kitamura, Hiroyuki Nishiyama, Nobuo Shinohara
Journal of geriatric oncology, 12, 5, 834, 837, 2021年06月, ［国際誌］
英語

Assessment of the confidence interval in the multivariable normal tissue complication probability model for predicting radiation-induced liver disease in primary liver cancer.
Anussara Prayongrat, Natchalee Srimaneekarn, Sira Sriswasdi, Yoichi M Ito, Norio Katoh, Masaya Tamura, Yasuhiro Dekura, Chie Toramatsu, Chonlakiet Khorprasert, Napapat Amornwichet, Petch Alisanant, Yuichi Hirata, Anthony Hayter, Hiroki Shirato, Shinichi Shimizu, Keiji Kobashi
Journal of radiation research, 62, 3, 483, 493, 2021年05月12日, ［国際誌］
英語, 研究論文（学術雑誌）

Acute Oral Calcium Suppresses Food Intake Through Enhanced Peptide-YY Secretion Mediated by the Calcium-Sensing Receptor in Rats.
Akiho Igarashi, Shono Ogasawara, Ryo Takagi, Kazufumi Okada, Yoichi M Ito, Hiroshi Hara, Tohru Hira
The Journal of nutrition, 151, 5, 1320, 1328, 2021年05月11日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Dietary calcium has been proposed to reduce appetite in human studies. Postprandial satiety is mainly controlled by gut hormones. However, the effect of calcium on appetite and the role of gut hormones remain unclear. OBJECTIVES: We examined whether oral administration of calcium reduces food intake in rats and investigated the underlying mechanism. METHODS: Male Sprague Dawley rats (8-12 wk old) were used after an overnight fastifffng. In a series of 2 trials with 1-wk interval between challenges, food intake was measured 0.5-24 h after oral gavage of a vehicle (saline containing 1.5% carboxymethyl cellulose) as the control treatment, or the vehicle containing various calcium compounds [calcium chloride (CaCl2), calcium carbonate, calcium lactate, in a random order] at 150 mg calcium/kg dose. A conditional taste aversion test was conducted. In separate experiments, plasma calcium and gut hormone concentrations were measured 15 or 30 min after oral administration of the calcium compounds. In anesthetized rats, portal peptide-YY (PYY) concentrations were measured after intraluminal administration of a liquid meal with or without additional calcium. RESULTS: Oral CaCl2 reduced food intake acutely (30 min, ∼20%, P < 0.05) compared with control rats, without taste aversion. Plasma PYY concentration was higher (100%, P < 0.05) in CaCl2-preloaded rats than in control rats, 15 min after administration. In anesthetized rats, luminal meal + CaCl2 induced a 4-fold higher increase in plasma PYY than the control treatment did. Oral administration of a calcium-sensing receptor (CaSR) agonist suppressed food intake (∼30%, P < 0.05), but CaCl2 and CaSR agonist did not suppress food intake under treatment with a PYY receptor antagonist. Furthermore, the CaSR antagonist attenuated the effect of CaCl2 on food intake. CONCLUSIONS: CaCl2 suppresses food intake partly by increasing CaSR-mediated PYY secretion in rats. Our findings could at least partially explain the satiating effect of calcium.

Effects of Repeated 131I-Meta-Iodobenzylguanidine Radiotherapy on Tumor Size and Tumor Metabolic Activity in Patients with Metastatic Neuroendocrine Tumors.
Keiichiro Yoshinaga, Takashige Abe, Shozo Okamoto, Yuko Uchiyama, Osamu Manabe, Yoichi M Ito, Naomi Tamura, Natsue Ito, Naho Yoshioka, Komei Washino, Nobuo Shinohara, Nagara Tamaki, Tohru Shiga
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 62, 5, 685, 694, 2021年05月10日, ［国際誌］
英語, 研究論文（学術雑誌）

Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring.
Aika Miya, Akinobu Nakamura, Takahisa Handa, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, So Nagai, Yoichi M Ito, Hideaki Miyoshi, Tatsuya Atsumi
Scientific reports, 11, 1, 9057, 9057, 2021年04月27日, ［国際誌］
英語, 研究論文（学術雑誌）

Mediating Factors Between Parental Socioeconomic Status and Small for Gestational Age in Infants: Results from the Hokkaido Study on Environment and Children’s Health
Naomi Tamura, Tomoyuki Hanaoka, Kumiko Ito, Atsuko Araki, Chihiro Miyashita, Sachiko Ito, Sumitaka Kobayashi, Yoichi Ito, Hisanori Minakami, Kazutoshi Cho, Toshiaki Endo, Tsuyoshi Baba, Kazuo Sengoku, Toshinobu Miyamoto, Katsuhiko Ogasawara, Reiko Kishi
Maternal and Child Health Journal, 25, 4, 645, 655, Springer Science and Business Media LLC, 2021年04月
研究論文（学術雑誌）

Intravenous infusion of auto serum-expanded autologous mesenchymal stem cells in spinal cord injury patients: 13 case series.
Osamu Honmou, Toshihiko Yamashita, Tomonori Morita, Tsutomu Oshigiri, Ryosuke Hirota, Satoshi Iyama, Junji Kato, Yuichi Sasaki, Sumio Ishiai, Yoichi M Ito, Ai Namioka, Takahiro Namioka, Masahito Nakazaki, Yuko Kataoka-Sasaki, Rie Onodera, Shinichi Oka, Masanori Sasaki, Stephen G Waxman, Jeffery D Kocsis
Clinical neurology and neurosurgery, 203, 106565, 106565, 2021年04月, ［国際誌］
英語, 研究論文（学術雑誌）

ロボット支援腹腔鏡下前立腺全摘除術における神経温存が健康関連QOLに及ぼす影響
大澤 崇宏, 安部 崇重, 松本 隆児, 菊地 央, 山田 修平, 古御堂 純, 宮田 遥, 村井 祥代, 伊藤 陽一, 篠原 信雄
泌尿器外科, 34, 3, 321, 321, 医学図書出版(株), 2021年03月
日本語

Comparison of Health-Related Quality of Life Between Japanese and American Patients with Bladder Cancer as Measured by a Newly Developed Japanese Version of the Bladder Cancer Index
Takahiro Osawa, John T. Wei, Takashige Abe, Michitaka Honda, Karl T. Rew, Rod Dunn, Shuhei Yamada, Jun Furumido, Hiroshi Kikuchi, Ryuji Matsumoto, Yasuyuki Sato, Toni Harabayashi, Norikata Takada, Keita Minami, Ken Morita, Akira Kashiwagi, Shunichi Fukuhara, Sachiyo Murai, Yoichi M. Ito, Katsuhiko Ogasawara, Nobuo Shinohara
BLADDER CANCER, 7, 1, 61, 69, 2021年
英語, 研究論文（学術雑誌）

Health-related quality of life in Japanese patients with bladder cancer measured by a newly developed Japanese version of the Bladder Cancer Index.
Takahiro Osawa, John T Wei, Takashige Abe, Michitaka Honda, Shuhei Yamada, Jun Furumido, Hiroshi Kikuchi, Ryuji Matsumoto, Kazushi Hirakawa, Yasuyuki Sato, Yoshihiro Sasaki, Toru Harabayashi, Norikata Takada, Keita Minami, Hiroshi Tanaka, Ken Morita, Akira Kashiwagi, Naoto Miyajima, Tomoshige Akino, Sachiyo Murai, Yoichi M Ito, Shunichi Fukuhara, Katsuhiko Ogasawara, Nobuo Shinohara
International journal of clinical oncology, 25, 12, 2090, 2098, 2020年12月, ［国内誌］
英語, 研究論文（学術雑誌）

Quantitative analysis of treatments using real-time image gated spot-scanning with synchrotron-based proton beam therapy system log data.
Takaaki Yoshimura, Shinichi Shimizu, Takayuki Hashimoto, Kentaro Nishioka, Norio Katoh, Hiroshi Taguchi, Koichi Yasuda, Taeko Matsuura, Seishin Takao, Masaya Tamura, Sodai Tanaka, Yoichi M Ito, Yuto Matsuo, Hiroshi Tamura, Kenji Horita, Kikuo Umegaki, Hiroki Shirato
Journal of applied clinical medical physics, 21, 12, 10, 19, 2020年12月, ［国際誌］
英語, 研究論文（学術雑誌）

Resveratrol improves motor function in patients with muscular dystrophies: an open-label, single-arm, phase IIa study.
Kentaro Kawamura, Shinobu Fukumura, Koki Nikaido, Nobutada Tachi, Naoki Kozuka, Tsugumi Seino, Kingya Hatakeyama, Mitsuru Mori, Yoichi M Ito, Akiyoshi Takami, Shiro Hinotsu, Atsushi Kuno, Yukihiko Kawasaki, Yoshiyuki Horio, Hiroyuki Tsutsumi
Scientific reports, 10, 1, 20585, 20585, 2020年11月25日, ［国際誌］
英語, 研究論文（学術雑誌）

Reference values for the locomotive syndrome risk test quantifying mobility of 8681 adults aged 20-89 years: A cross-sectional nationwide study in Japan.
Keiko Yamada, Yoichi M Ito, Masao Akagi, Etsuo Chosa, Takeshi Fuji, Kenichi Hirano, Shinichi Ikeda, Hideaki Ishibashi, Yasuyuki Ishibashi, Muneaki Ishijima, Eiji Itoi, Norimasa Iwasaki, Ryoichi Izumida, Ken Kadoya, Masayuki Kamimura, Arihiko Kanaji, Hiroyuki Kato, Shunji Kishida, Naohiko Mashima, Shuichi Matsuda, Yasumoto Matsui, Toshiki Matsunaga, Naohisa Miyakoshi, Hiroshi Mizuta, Yutaka Nakamura, Ken Nakata, Go Omori, Koji Osuka, Yuji Uchio, Kazuteru Ryu, Nobuyuki Sasaki, Kimihito Sato, Masuo Senda, Akihiro Sudo, Naonobu Takahira, Hiroshi Tsumura, Satoshi Yamaguchi, Noriaki Yamamoto, Kozo Nakamura, Takashi Ohe
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25, 6, 1084, 1092, 2020年11月, ［国内誌］
英語, 研究論文（学術雑誌）

Combination of minimum wiping pressure and number of wipings that can remove pseudo-skin dirt: A digital image color analysis.
Issei Konya, Inaho Shishido, Yoichi M Ito, Rika Yano
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 26, 5, 639, 647, 2020年09月, ［国際誌］
英語, 研究論文（学術雑誌）

Social participation patterns and the incidence of functional disability: The Japan Gerontological Evaluation Study.
Shigekazu Ukawa, Akiko Tamakoshi, Yutaka Okada, Yoichi M Ito, Rika Taniguchi, Yukako Tani, Yuri Sasaki, Junko Saito, Maho Haseda, Naoki Kondo, Katsunori Kondo
Geriatrics & gerontology international, 20, 8, 765, 772, 2020年08月, ［国内誌］
英語, 研究論文（学術雑誌）

Right ventriculo-pulmonary arterial uncoupling and poor outcomes in pulmonary arterial hypertension
Toshitaka Nakaya, Hiroshi Ohira, Takahiro Sato, Taku Watanabe, Masaharu Nishimura, Noriko Oyama-Manabe, Masaru Kato, Yoichi M. Ito, Ichizo Tsujino
PULMONARY CIRCULATION, 10, 3, 2020年07月
英語, 研究論文（学術雑誌）

Oncological outcomes of a multicenter cohort treated with axitinib for metastatic renal cell carcinoma.
Takahiro Osawa, Takahiro Kojima, Tomohiko Hara, Mikio Sugimoto, Masatoshi Eto, Ario Takeuchi, Keita Minami, Yasutomo Nakai, Kosuke Ueda, Michinobu Ozawa, Motohide Uemura, Yasuyuki Miyauchi, Kojiro Ohba, Toshiro Suzuki, Satoshi Anai, Tetsuya Shindo, Naohisa Kusakabe, Keita Tamura, Motokiyo Komiyama, Takayuki Goto, Akira Yokomizo, Naoki Kohei, Akira Kashiwagi, Masaya Murakami, Tomokazu Sazuka, Hiroaki Yasumoto, Hideto Iwamoto, Koji Mitsuzuka, Daichi Morooka, Toru Shimazui, Yoshiaki Yamamoto, Suguru Ikeshiro, Hiroshi Nakagomi, Ken Morita, Ryotaro Tomida, Tango Mochizuki, Takamitsu Inoue, Hiroshi Kitamura, Shuhei Yamada, Yoichi M Ito, Sachiyo Murai, Hiroyuki Nishiyama, Nobuo Shinohara
Cancer science, 111, 7, 2460, 2471, 2020年07月, ［国際誌］
英語, 研究論文（学術雑誌）

Prenatal exposure to 11 perfluoroalkyl substances and fetal growth: A large-scale, prospective birth cohort study.
Ikuko Kashino, Seiko Sasaki, Emiko Okada, Hideyuki Matsuura, Houman Goudarzi, Chihiro Miyashita, Eisaku Okada, Yoichi M Ito, Atsuko Araki, Reiko Kishi
Environment international, 136, 105355, 105355, 2020年03月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Changes in cerebral oxygen saturation during one-lung ventilation determined using spatially resolved spectroscopy and contributing factors.
Nobuhiro Tanaka, Ryoko Ito Katoh, Masataka Yamamoto, Koji Hoshino, Yuji Morimoto, Yoichi M Ito, Tatsuya Kato
Journal of clinical anesthesia, 59, 99, 100, 2020年02月, ［査読有り］, ［国際誌］
英語

Single-Center Noninferiority Randomized Trial on the Efficacy and Safety of Low- and High-Dose Rush Oral Milk Immunotherapy for Severe Milk Allergy.
Yuri Takaoka, Yuko Yajima, Yoichi M Ito, Junko Kumon, Takahiro Muroya, Yuki Tsurinaga, Amane Shigekawa, Shinichi Takahashi, Norihito Iba, Taisuke Tsuji, Tomoki Nishikido, Yukinori Yoshida, Satoru Doi, Makoto Kameda
International archives of allergy and immunology, 181, 9, 699, 705, 2020年, ［国際誌］
英語, 研究論文（学術雑誌）

The urethral position may shift due to urethral catheter placement in the treatment planning for prostate radiation therapy.
Yasuhiro Dekura, Kentaro Nishioka, Takayuki Hashimoto, Naoki Miyamoto, Ryusuke Suzuki, Takaaki Yoshimura, Ryuji Matsumoto, Takahiro Osawa, Takashige Abe, Yoichi M Ito, Nobuo Shinohara, Hiroki Shirato, Shinichi Shimizu
Radiation oncology (London, England), 14, 1, 226, 226, 2019年12月12日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

The development of the preoperative nomogram predicting major perioperative complications after radical cystectomy with ileal conduit or orthotopic neobladder
Shuhei Yamada, Takahiro Osawa, Takashige Abe, Norikata Takada, Ryuji Matsumoto, Yoichi M. Ito, Hiroshi Kikuchi, Naoto Miyajima, Kunihiko Tsuchiya, Satoru Maruyama, Sachiyo Murai, Nobuo Shinohara
Acta Urologica Japonica, 65, 12, 495, 499, Editorial Board of Acta Urologica Japonica, 2019年12月01日
日本語, 研究論文（学術雑誌）

腸管利用尿路変向を行った開腹膀胱全摘除術における術前因子を用いた周術期重度合併症予測ノモグラムの作成の試み
山田 修平, 大澤 崇宏, 安部 崇重, 高田 徳容, 松本 隆児, 伊藤 陽一, 菊地 央, 宮島 直人, 土屋 邦彦, 丸山 覚, 村井 祥代, 篠原 信雄
泌尿器科紀要, 65, 12, 495, 499, 泌尿器科紀要刊行会, 2019年12月
日本語

Analysis of treatment process time for real-time-image gated-spot-scanning proton-beam therapy (RGPT) system.
Yoshimura T, Shimizu S, Hashimoto T, Nishioka K, Katoh N, Inoue T, Taguchi H, Yasuda K, Matsuura T, Takao S, Tamura M, Ito YM, Matsuo Y, Tamura H, Horita K, Umegaki K, Shirato H
Journal of applied clinical medical physics, 21, 2, 38, 49, 2019年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA-A24-positive pancreatic adenocarcinoma.
Hiroaki Shima, Giichiro Tsurita, Satoshi Wada, Yoshihiko Hirohashi, Hiroshi Yasui, Hiroshi Hayashi, Takashi Miyakoshi, Kazue Watanabe, Aiko Murai, Hiroko Asanuma, Serina Tokita, Terufumi Kubo, Munehide Nakatsugawa, Takayuki Kanaseki, Tomohide Tsukahara, Yutaka Nakae, Osamu Sugita, Yoichi M Ito, Yasunori Ota, Yasutoshi Kimura, Goro Kutomi, Koichi Hirata, Toru Mizuguchi, Kohzoh Imai, Ichiro Takemasa, Noriyuki Sato, Toshihiko Torigoe
Cancer science, 110, 8, 2378, 2385, 2019年08月, ［国際誌］
英語, 研究論文（学術雑誌）

Effects of femoral bone defect morphology on initial polished tapered stem stability in massive defect model: a biomechanical study.
Tohru Irie, Daisuke Takahashi, Tsuyoshi Asano, Tomohiro Shimizu, Ryuta Arai, Alaa Muhammad Terkawi, Yoichi M Ito, Norimasa Iwasaki
BMC musculoskeletal disorders, 20, 1, 355, 355, 2019年08月01日, ［国際誌］
英語, 研究論文（学術雑誌）

Impact of organ motion on volumetric and dosimetric parameters in stomach lymphomas treated with intensity-modulated radiotherapy.
Uchinami Y, Suzuki R, Katoh N, Taguchi H, Yasuda K, Miyamoto N, Ito YM, Shimizu S, Shirato H
Journal of applied clinical medical physics, 20, 8, 78, 86, 2019年08月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Safety and efficacy of amnion-derived mesenchymal stem cells (AM01) in patients with steroid-refractory acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation: a study protocol for a phase I/II Japanese trial.
Kenichi Yamahara, Akiko Hamada, Toshihiro Soma, Rika Okamoto, Masaya Okada, Satoshi Yoshihara, Kyoko Yoshihara, Kazuhiro Ikegame, Hiroya Tamaki, Katsuji Kaida, Takayuki Inoue, Yuko Ohsugi, Hiroki Nishikawa, Hiroshi Hayashi, Yoichi M Ito, Hiroaki Iijima, Shunsuke Ohnishi, Daigo Hashimoto, Toshiyuki Isoe, Takanori Teshima, Hiroyasu Ogawa, Norihiro Sato, Yoshihiro Fujimori
BMJ open, 9, 7, e026403, 2019年07月09日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Three-dimensional depth sensor imaging to identify adolescent idiopathic scoliosis: a prospective multicenter cohort study.
Terufumi Kokabu, Noriaki Kawakami, Koki Uno, Toshiaki Kotani, Teppei Suzuki, Yuichiro Abe, Kenichiro Maeda, Fujio Inage, Yoichi M Ito, Norimasa Iwasaki, Hideki Sudo
Scientific reports, 9, 1, 9678, 9678, 2019年07月04日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

cT1腎癌に対する開腹腎部分切除術と鏡視下腎部分切除術後のSF-36を用いたQOLの比較
大澤 崇宏, 安部 崇重, 菊地 央, 松本 隆児, 宮島 直人, 土屋 邦彦, 丸山 覚, 伊藤 陽一, 村井 祥代, 篠原 信雄
泌尿器外科, 32, 7, 985, 986, 医学図書出版(株), 2019年07月
日本語

Bladder Cancer Index(BCI)日本語版の妥当性検証
古御堂 純, 大澤 崇宏, 伊藤 陽一, 菊地 央, 松本 隆児, 平川 和志, 佐藤 泰之, 佐々木 芳浩, 高田 徳容, 原林 透, 柏木 明, 田中 博, 三浪 圭太, 森田 研, 山田 修平, 村井 祥代, 安部 崇重, 篠原 信雄
泌尿器外科, 32, 7, 991, 991, 医学図書出版(株), 2019年07月
日本語

Phase II study of trastuzumab and docetaxel therapy in patients with HER2-positive recurrent and/or metastatic salivary gland carcinoma
Ichiro Kinoshita, Satoshi Kano, Yasushi Shimizu, Naomi Kiyota, Yuichiro Tada, Kei Ijichi, Tmoko Yamazaki, Akihiro Homma, Yoichi M. Ito, Kota Ono, Keiko Kobayashi, Toshiyuki Isoe, Yutaka Hatanaka, Hitoshi Tsuda, Shojiroh Morinaga, Yoshihiro Matsuno, Hirotoshi Dosaka-Akita
CANCER RESEARCH, 79, 13, 2019年07月
英語

Three-dimensional depth sensor imaging to identify adolescent idiopathic scoliosis: a prospective multicenter cohort study　　　　　　　　　　　　　　　
Terufumi Kokabu, Noriaki Kawakami, Koki Uno, Toshiaki Kotani, Teppei Suzuki, Yuichiro Abe, Kenichiro Maeda, Fujio Inage, Yoichi M. Ito, Norimasa Iwasaki, Hideki Sudo
Scientific Reports, 9, 9678, 1, 8, 2019年07月, ［査読有り］
英語, 研究論文（学術雑誌）

The normal tissue complication probability model-based approach considering uncertainties for the selective use of radiation modality in primary liver cancer patients.
Prayongrat A, Kobashi K, Ito YM, Katoh N, Tamura M, Dekura Y, Toramatsu C, Khorprasert C, Amornwichet N, Alisanant P, Shirato H, Shimizu S
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 135, 100, 106, 2019年06月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Verification of the effectiveness of fucosylated haptoglobin as a pancreatic cancer marker in clinical diagnosis.
Kuwatani M, Kawakami H, Kubota Y, Kawakubo K, Ito YM, Togo S, Ikeda T, Kusama K, Kobayashi Y, Murata T, Sakamoto N
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 19, 4, 569, 577, 2019年06月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Bladder Cancer Index(BCI)日本語版の開発におけるPilot Study
大澤 崇宏, Wei John T., 伊藤 陽一, 成田 学, 賀古 勇輝, 宮田 遙, 菊地 央, 松本 隆児, 宮島 直人, 丸山 覚, 安部 崇重, 村井 祥代, 篠原 信雄
泌尿器外科, 32, 5, 518, 518, 医学図書出版(株), 2019年05月
日本語

Clinical experience of craniospinal intensity-modulated spot-scanning proton therapy using large fields for central nervous system medulloblastomas and germ cell tumors in children, adolescents, and young adults.
Hashimoto T, Shimizu S, Takao S, Terasaka S, Iguchi A, Kobayashi H, Mori T, Yoshimura T, Matsuo Y, Tamura M, Matsuura T, Ito YM, Onimaru R, Shirato H
Journal of radiation research, 60, 4, 527, 537, 2019年05月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Magnetic resonance imaging T1 and T2 mapping provide complementary information on the bone mineral density regarding cancellous bone strength in the femoral head of postmenopausal women with osteoarthritis.
Endo K, Takahata M, Sugimori H, Yamada S, Tadano S, Wang J, Todoh M, Ito YM, Takahashi D, Kudo K, Iwasaki N
Clinical biomechanics (Bristol, Avon), 65, 13, 18, 2019年05月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

The responsiveness of triaxial accelerometer measurement of gait ataxia is higher than that of the Scale for the Assessment and Rating of Ataxia in the early stages of spinocerebellar ataxia
Shirai S, Yabe I, Takahashi-Iwata I, Matsushima M, Ito YM, Takakusaki K, Sasaki H
Cerebellum, 18, 4, 721, 730, 2019年04月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Identifying the Essential Portions of the Skill Acquisition Process Using Item Response Theory.
Poudel S, Watanabe Y, Kurashima Y, Ito YM, Murakami Y, Tanaka K, Kawase H, Shichinohe T, Hirano S
Journal of surgical education, 76, 4, 1101, 1106, 2019年02月, ［査読有り］
英語, 研究論文（学術雑誌）

Progressive left ventricular dysfunction and myocardial fibrosis in Duchenne and Becker muscular dystrophy: a longitudinal cardiovascular magnetic resonance study.
Tadao Aikawa, Atsuhito Takeda, Noriko Oyama-Manabe, Masanao Naya, Hirokuni Yamazawa, Kazuhiro Koyanagawa, Yoichi M Ito, Toshihisa Anzai
Pediatric cardiology, 40, 2, 384, 392, 2019年02月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

The relationship between prenatal psychological stress and placental abruption in Japan, The Japan Environment and Children's Study (JECS).
Kawanishi Y, Yoshioka E, Saijo Y, Itoh T, Miyamoto T, Sengoku K, Ito Y, Ito S, Miyashita C, Araki A, Endo T, Cho K, Minakami H, Kishi R, Japan Environment, Children’s Study Group
PloS one, 14, 7, e0219379, 2019年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Prenatal psychological stress may increase the risk of placental abruption (PA). This study aimed to clarify the effects of psychological distress during pregnancy and exposure to stressful life events in the year before or during pregnancy on the occurrence of PA in Japanese women. METHODS: Using a nationwide prospective birth cohort study, we obtained data from 103,099 women between January 2011 and March 2014. Information on exposure to 14 stressful life events and psychological distress (Kessler 6 scale) was collected using a self-administered questionnaire during pregnancy. Clinical diagnoses of PA were obtained from medical records. A total of 80,799 women with singleton births were analyzed using logistic regression models that adjusted for possible confounders. RESULTS: PA was diagnosed in 335 (0.4%) women. There was no significant difference in the Kessler 6 score during pregnancy between the PA group and non-PA group. Exposure to the death of a child in the year before or during pregnancy was significantly associated with PA in multigravid women (adjusted odds ratio [aOR] 3.57; 95% confidence interval [CI] 1.50-8.34). A spouse's loss of employment was significantly associated with PA in parous women (aOR 3.25; 95% CI 1.40-7.56). CONCLUSIONS: This study identified the possible effects of exposure to the death of a child on PA occurrence that adjusted for important confounding factors.

Identifying a risk score for childhood obesity based on predictors identified in pregnant women and 1-year-old infants: An analysis of the data of the Hokkaido Study on Environment and Children's Health.
Saijo Y, Ito Y, Yoshioka E, Sato Y, Minatoya M, Araki A, Miyashita C, Kishi R
Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology, 28, 3, 81, 89, 2019年, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）, This study aimed to construct a childhood obesity risk index based on predictors identified in pregnant women and 1-yr-old infants. The primary outcome was an identified obesity index of > 20% at 6-8 yr of age. Of a total sample size of 6,846 mother-child pairs, 80% and 20% were randomly allocated to the derivation and validation cohorts, respectively. For the derivation cohort, univariate and multivariate logistic regression analyses of data were conducted to identify the final predictors to determine the childhood obesity risk score algorithm. These included pre-pregnancy body mass index (BMI), child's gender, smoking during pregnancy, education, and obesity index at one yr of age. The β coefficients for categories of predictor variables were each divided by the smallest value among them. The quotient was rounded off to the integer and assigned to the risk score, and a value of zero was assigned to reference categories. A total risk score was calculated for each individual. A cutoff point ≥ 16 had 22.2% and 21.8% positive predictive values in the derivation and validation cohorts, respectively. In conclusion, the childhood obesity risk score algorithm was constructed based on generic predictors that can be easily obtained from maternal and child health handbooks.

Effectiveness and Safety of Double-Blind, Placebo-Controlled, Low-Dose Oral Immunotherapy with Low Allergen Egg-Containing Cookies for Severe Hen's Egg Allergy: A Single-Center Analysis.
Yuri Takaoka, Akihiro Maeta, Kyoko Takahashi, Yoichi M Ito, Shinichi Takahashi, Takahiro Muroya, Amane Shigekawa, Yuki Tsurinaga, Norihito Iba, Yukinori Yoshida, Makoto Kameda, Satoru Doi
International archives of allergy and immunology, 180, 4, 244, 249, 2019年, ［国際誌］
英語, 研究論文（学術雑誌）

Complications Related to the Initial Trocar Insertion of 3 Different Techniques: A Systematic Review and Meta-analysis
Nishimura, Mai Department of Obstetrics, Gynecology, Teine Keijinkai Hospital, Matsumoto, Sachiko Department of Obstetrics, Gynecology, Teine Keijinkai Hospital, Ohara, Yasuhiro Department of Obstetrics, Gynecology, Teine Keijinkai Hospital, Minowa, Kaoru Department of Obstetrics, Gynecology, Teine Keijinkai Hospital, Tsunematsu, Risa Department of Obstetrics, Gynecology, Teine Keijinkai Hospital, Takimoto, Kanako Department of Obstetrics, Gynecology, Teine Keijinkai Hospital, Imai, Kazuaki Department of Obstetrics, Gynecology, Teine Keijinkai Hospital, Tsuzuki, Yoko Department of Obstetrics, Gynecology, Teine Keijinkai, Hospital, Ota, Hajime Department of Obstetrics, Gynecology, Teine Keijinkai Hospital, Nakajima, Ayako Department of Obstetrics, Gynecology, Teine Keijinkai, Hospital, Fukushi, Yoshiyuki Department of Obstetrics, Gynecology, Teine Keijinkai Hospital, Wada, Shinichiro Department of Obstetrics, Gynecology, Teine Keijinkai Hospital, Fujino, Takafumi Department of Obstetrics, Gynecology, Teine Keijinkai Hospital, M.Ito, Yoichi Department, of Biostatistics, Faculty of Medicine, Graduate School of, Medicine, Hokkaido University
The Journal of Minimally Invasive Gynecology, 26, 1, 63, 70, 2019年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Effects of coronary revascularization on global coronary flow reserve in stable coronary artery disease.
Tadao Aikawa, Masanao Naya, Masahiko Obara, Osamu Manabe, Keiichi Magota, Kazuhiro Koyanagawa, Naoya Asakawa, Yoichi M Ito, Tohru Shiga, Chietsugu Katoh, Toshihisa Anzai, Hiroyuki Tsutsui, Venkatesh L Murthy, Nagara Tamaki
Cardiovascular research, 115, 1, 119, 129, 2019年01月01日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Nationwide survey on the organ-specific prevalence and its interaction with sarcoidosis in Japan
Takeshi Hattori, Satoshi Konno, Noriharu Shijubo, Tetsuo Yamaguchi, Yukihiko Sugiyama, Sakae Honma, Naohiko Inase, Yoichi M. Ito, Masaharu Nishimura
Scientific Reports, 8, 1, 9440, 9440, 2018年12月01日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Automated noninvasive detection of idiopathic scoliosis in children and adolescents: A principle validation study
Sudo, Hideki Department of, Advanced Medicine for Spine, Spinal Cord Disorders, Faculty of Medicine, Graduate of Medicine, Hokkaido University, Kokabu, Terufumi Department of Orthopaedic Surgery, Hokkaido University Hospital, Abe, Yuichiro Department of Orthopaedic Surgery, Eniwa Hospital, Iwata, Akira Department, of Orthopaedic Surgery, Hokkaido University Hospital, Yamada, Katsuhisa Department of Orthopaedic Surgery, Hokkaido University Hospital, M. Ito, Yoichi Department, of Biostatistics, Hokkaido University, Graduate School of, Medicine, Iwasaki, Norimasa Department of Orthopaedic Surgery, Hokkaido University, Hospital, Kanai, Satoshi Division of, Systems Science, Informatics, Hokkaido University, Graduate School of, Information Science, Technology
Scientific Reports, 8, 1, 17714, 17714, 2018年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Uncertainties of Normal Tissue Complication Probability (NTCP) and NTCP Difference between Radiation Treatment Modalities for Radiation-Induced Liver Toxicity in Child-Pugh A Primary Liver Cancer Patients
A. Prayongrat, K. Kobashi, Y. Ito, N. Katoh, Y. Dekura, N. Amornwichet, S. Shimizu, H. Shirato
International Journal of Radiation Oncology*Biology*Physics, 102, 3, e65, e66, Elsevier BV, 2018年11月
研究論文（学術雑誌）

Analysis of Beam Delivery Times and Dose Rates for the Treatment of Mobile Tumors Using Real Time Image Gated Spot-Scanning Proton Beam Therapy
S. Shimizu, T. Yoshimura, N. Katoh, T. Inoue, T. Hashimoto, K. Nishioka, S. Takao, T. Matsuura, N. Miyamoto, Y.M. Ito, K. Umegaki, H. Shirato
International Journal of Radiation Oncology*Biology*Physics, 102, 3, S182, S183, Elsevier BV, 2018年11月
研究論文（学術雑誌）

Impact of Abdominal Visceral Adiposity on Adult Asthma Symptoms.
Goudarzi H, Konno S, Kimura H, Makita H, Matsumoto M, Takei N, Kimura H, Shimizu K, Suzuki M, Ito YM, Nishimura M, Hi-CARAT investigators
The journal of allergy and clinical immunology. In practice, 7, 4, 1222, 1229, 2018年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

An acellular bioresorbable ultra-purified alginate gel promotes intervertebral disc repair: A preclinical proof-of-concept study.
Takeru Tsujimoto, Hideki Sudo, Masahiro Todoh, Katsuhisa Yamada, Koji Iwasaki, Takashi Ohnishi, Naoki Hirohama, Takayuki Nonoyama, Daisuke Ukeba, Katsuro Ura, Yoichi M Ito, Norimasa Iwasaki
EBioMedicine, 37, 521, 534, 2018年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Contrasting associations of maternal smoking and pre-pregnancy BMI with wheeze and eczema in children
Houman Goudarzi, Satoshi Konno, Hirokazu Kimura, Atsuko Araki, Chihiro Miyashita, Sachiko Itoh, Yu Ait Bamai, Hiroki Kimura, Kaoruko Shimizu, Masaru Suzuki, Yoichi M. Ito, Masaharu Nishimura, Reiko Kishi
Science of the Total Environment, 639, 1601, 1609, 2018年10月15日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Predictive factors for hyperglycaemic progression in patients with schizophrenia or bipolar disorder
Kusumi, Ichiro Department of Psychiatry, Hokkaido University, Graduate School of, Medicine, Arai, Yuki Department of Psychiatry, Wakkanai City Hospital, Okubo, Ryo Department of Psychiatry, Hokkaido University, Graduate School of Medicine, Honda Memorial, Hospital, Honda, Minoru Honda Memorial Hospital, Matsuda, Yasuhiro Department of Psychiatry, Nara Medical University, Matsuda, Yukihiko Hosogi, Unity, Hospital, Tochigi, Akihiko Tomakomai, Midorigaoka Hospital, Takekita, Yoshiteru Department of Neuropsychiatry, Kansai Medical University, Yamanaka, Hiroyoshi Okamoto Hospital, Uemura, Keiichi Department of Psychiatry, Sapporo City General Hospital, Ito, Koichi, Sapporo, Hanazono Hospital, Tsuchiya, Kiyoshi Tomakomai, Midorigaoka Hospital, Yamada, Jun, Kei-ai Hospital, Yoshimura, Bunta Okayama, Psychiatric Medical Center, Mitsui, Nobuyuki Department of Psychiatry, Hokkaido University, Graduate School of Medicine, Department of Psychiatry, Wakkanai City Hospital, Matsubara, Sigehiro Department of Neuropsychiatry, Obihiro National, Hospital, Segawa, Takayuki Okamoto, Hospital, Nishi, Nobuyuki Nishi, Hospital, Sugawara, Yasufumi Teine, Hospital, Kako, Yuki Department of Psychiatry, Hokkaido University, Graduate School of Medicine, Shinkawa, Ikuta Okayama, Psychiatric Medical Center, Shinohara, Kaoru, Sapporo, Suzuki Hospital, Konishi, Akiko Okayama, Psychiatric Medical Center, Iga, Junichi Department of Psychiatry, Tokushima University, Department of Psychiatry, Ehime University, Hashimoto, Naoki Department of Psychiatry, Hokkaido University, Graduate School of, Medicine, Inomata, Shinsaku Hizen, Psychiatric Center, Tsukamoto, Noriko Hakodate, Watanabe Hospital, Ito, Hiroto National, Institute of, Occupational Safety, d Health, National Center of, Neurology, Psychiatry, M. Ito, Yoichi Department, of Biostatistics, Hokkaido University, Graduate School of, Medicine, Sato, Norihiro Hokkaido, University Hospital Clinical Research, Medical Innovation Center
BJPsych Open, 4, 6, 454, 460, 2018年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Stereotactic body radiotherapy to treat small lung lesions clinically diagnosed as primary lung cancer by radiological examination: A prospective observational study
Tetsuya Inoue, Norio Katoh, Yoichi M Ito, Tomoki Kimura, Yasushi Nagata, Kengo Kuriyama, Hiroshi Onishi, Tadamasa Yoshitake, Yoshiyuki Shioyama, Yusuke Iizuka, Koji Inaba, Koji Konishi, Masaki Kokubo, Katsuyuki Karasawa, Takuyo Kozuka, Kensuke Tanaka, Jun Sakakibara-Konishi, Ichiro Kinoshita, Hiroki Shirato
Lung Cancer, 122, 107, 112, 2018年08月01日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Should sulfonylurea be discontinued or maintained at the lowest dose when starting ipragliflozin? A multicenter observational study in Japanese patients with type 2 diabetes.
Takahashi K, Cho KY, Nakamura A, Miya A, Miyoshi A, Yamamoto C, Nomoto H, Niwa H, Takahashi K, Manda N, Kurihara Y, Aoki S, Ito YM, Atsumi T, Miyoshi H
Journal of diabetes investigation, 10, 2, 429, 438, 2018年08月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Validation of the nomogram for predicting 90-day mortality after radical cystectomy in a Japanese cohort
Osawa, Takahiro Department of Urology, Hokkaido University, Graduate School of, Medicine, Abe, Takashige Department of Urology, Hokkaido University, Graduate School of, Medicine, Takada, Norikata Department of Urology, Hokkaido University, Graduate School of Medicine, M. Ito, Yoichi Department, of Biostatistics, Hokkaido University, Graduate School of, Medicine, Murai, Sachiyo Department of Urology, Hokkaido University, Graduate School of, Medicine, Shinohara, Nobuo Department of Urology, Hokkaido University, Graduate School of Medicine
International Journal of Urology, 25, 7, 699, 701, 2018年08月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Prediction of major depressive episodes and suicide-related ideation over a 3-year interval among Japanese undergraduates.
Mitsui, Nobuyuki Department of Psychiatry, Hokkaido University, Graduate School of, Medicine, Asakura, SAtoshi Department of Psychiatry, Hokkaido University, Graduate School of Medicine, Takanobu, Keisuke Department of Psychiatry, Hokkaido University, Graduate School of Medicine, Watanabe, Shinya Department of Psychiatry, Hokkaido University, Graduate School of, Medicine, Toyoshima, Kuniyoshi Department of Psychiatry, Hokkaido University, Graduate School of, Medicine, Kako, Yuki Department of Psychiatry, Hokkaido University, Graduate School of, Medicine, Ito, Yoichi M. Department, of Biostatistics, Hokkaido University, Graduate School of, Medicine, Kusumi, Ichiro Department of Psychiatry, Hokkaido University, Graduate School of Medicine
PloS one., 13, 7, e0201047, 2018年07月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Is There an Association Between Borderline-to-mild Dysplasia and Hip Osteoarthritis? Analysis of CT Osteoabsorptiometry.
Tohru Irie, Daisuke Takahashi, Tsuyoshi Asano, Ryuta Arai, Muhammad Alaa Terkawi, Yoichi M Ito, Norimasa Iwasaki
Clinical orthopaedics and related research, 476, 7, 1455, 1465, 2018年07月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Antitumor effects of radionuclide treatment using α-emitting meta-211At-astato-benzylguanidine in a PC12 pheochromocytoma model
Yasuhiro Ohshima, Hitomi Sudo, Shigeki Watanabe, Kotaro Nagatsu, Atsushi B. Tsuji, Tetsuya Sakashita, Yoichi M. Ito, Keiichiro Yoshinaga, Tatsuya Higashi, Noriko S. Ishioka
European Journal of Nuclear Medicine and Molecular Imaging, 45, 6, 999, 1010, 2018年06月01日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

An epigenome-wide study of cord blood DNA methylations in relation to prenatal perfluoroalkyl substance exposure: The Hokkaido study
Ryu Miura, Atsuko Araki, Chihiro Miyashita, Sumitaka Kobayashi, Sachiko Kobayashi, Shu-Li Wang, Chung-Hsing Chen, Kunio Miyake, Mayumi Ishizuka, Yusuke Iwasaki, Yoichi M. Ito, Takeo Kubota, Reiko Kishi
Environment International, 115, 21, 28, 2018年06月01日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Educational system based on the TAPP checklist improves the performance of novices: a multicenter randomized trial
Saseem Poudel, Yo Kurashima, Kimitaka Tanaka, Hiroshi Kawase, Yoichi M. Ito, Fumitaka Nakamura, Toshiaki Shichinohe, Satoshi Hirano
Surgical Endoscopy and Other Interventional Techniques, 32, 5, 2480, 2487, 2018年05月01日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

母親の喫煙およびBMIと小児の喘鳴および湿疹との対照的な関連性(Contrasting associations of maternal smoking and BMI with wheeze and eczema in children)
Goudarzi Houman, Konno Satoshi, Kimura Hirokazu, Araki Atsuko, Miyashita Chihiro, Itou Sachiko, Bamai Yu Ait, Kimura Hiroki, Shimizu Kaoruko, Suzuki Masaru, Ito Yoichi, Nishimura Masaharu, Kishi Reiko
アレルギー, 67, 4-5, 509, 509, (一社)日本アレルギー学会, 2018年05月
英語

Prospective predictors of exacerbation status in severe asthma over a 3-year follow-up
Kimura, H. Department of Respiratory Medicine, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Konno, S. Department of Respiratory Medicine, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Makita, H. Department of Respiratory Medicine, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Taniguchi, N. Department of Respiratory Medicine, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Shimizu, K. Department of Respiratory Medicine, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Suzuki, M. Department of Respiratory Medicine, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Kimura, H. Department of Respiratory Medicine, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Goudarzi, H. Department of Respiratory Medicine, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Nakamaru, Y. Otolaryngology Head, Neck Surgery, Hokkaido University School of Medicine, Ono, J, Shino-Test Corporation, Ohta, S. Division of, Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Izuhara, K. Division of, Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, M. Ito, Y. Department, of Biostatistics, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, E. Wenzel, S. University of Pittsburgh Asthma, Institute at UPMC, University of Pittsburgh School of Medicine, Nishimura, M. Department of Respiratory Medicine, Faculty of Medicine, Graduate School of Medicine, Hokkaido University
Clinical and Experimental Allergy, 48, 9, 1137, 46, 2018年05月, ［査読有り］
研究論文（学術雑誌）

Effect of combined treatment with bisphosphonate and vitamin D on atherosclerosis in patients with systemic lupus erythematosus: a propensity score-based analysis.
Kazumasa Ohmura, Masaru Kato, Toshiyuki Watanabe, Kenji Oku, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Yoichi M Ito, Norihiro Sato, Tatsuya Atsumi
Arthritis research & therapy, 20, 1, 72, 72, 2018年04月17日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Effects of dietary supplementation with milk fat globule membrane on the physical performance of community-dwelling Japanese adults: a randomised, double-blind, placebo-controlled trial.
Kokai, Yasuo Department, of Biomedical Engineering, Sapporo Medical University School of Medicine, Mikami, Nana Department, of Biomedical Engineering, Sapporo Medical University School of, Medicine, Tada, Mitsuhiro Department of Neurosurgery, Rumoi Municipal Hospital, Tomonobu, Kazuishi ealth, Care Food, Research Laboratory, Kao Corporation, Ochiai, Ryuji ealth, Care Food, Research Laboratory, Kao Corporation, Osaki, Noriko ealth, Care Food, Research Laboratory, Kao Corporation, Katsuragi, Yoshihisa ealth, Care Food, Research Laboratory, Kao Corporation, Sohma, Hitoshi Department of Educational Development, Sapporo Medical, University Center for Medical Education, Ito, Yoichi M. Department, of Biostatics, Hokkaido University, Graduate School of Medicine
Journal of Nutritional Science., 7, e18, 2018年04月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

LONG-TERM EFFECTS OF ANGIOTENSIN CONVERTING ENZYME INHIBITOR ON LEFT VENTRICULAR EJECTION FRACTION IN DUCHENNE AND BECKER MUSCULAR DYSTROPHY: A LONGITUDINAL CARDIAC MAGNETIC RESONANCE IMAGING STUDY
Tadao Aikawa, Atsuhito Takeda, Noriko Oyama-Manabe, Masanao Naya, Hirokuni Yamazawa, Kazuhiro Koyanagawa, Yoichi M. Ito, Yuka Ishikawa, Yukitoshi Ishikawa, Toshihisa Anzai
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 71, 11, 1565, 1565, 2018年03月, ［査読有り］
英語

Present developments in reaching an international consensus for a model-based approach to particle beam therapy.
Anussara Prayongrat, Kikuo Umegaki, Arjen van der Schaaf, Albert C Koong, Steven H Lin, Thomas Whitaker, Todd McNutt, Naruhiro Matsufuji, Edward Graves, Masahiko Mizuta, Kazuhiko Ogawa, Hiroyuki Date, Kensuke Moriwaki, Yoichi M Ito, Keiji Kobashi, Yasuhiro Dekura, Shinichi Shimizu, Hiroki Shirato
Journal of radiation research, 59, suppl_1, i72-i76, I76, 2018年03月01日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Assessing the uncertainty in a normal tissue complication probability difference (ΔNTCP): radiation-induced liver disease (RILD) in liver tumour patients treated with proton vs X-ray therapy
Kobashi, Keiji Department of Medical Physics, Hokkaido University Hospital, Prayongrat, Anussara Department of, Radiation Oncology, Graduate School of Medicine, Hokkaido University, Kimoto, Takuya Department, of Radiology, Kyoto Prefectural, University of Medicine, Toramatsu, Chie Department of, Radiation Oncology, Tokyo Women’s Medical University, Dekura, Yasuhiro Department of, Radiation Oncology, Graduate School of Medicine, Hokkaido University, Katoh, Norio Department of, Radiation Oncology, Hokkaido University Hospital, Shimizu, Shinichi Department of, Radiation Oncology, Faculty of Medicine, Hokkaido University, M. Ito, Yoichi Department, of Biostatistics, Faculty of Medicine, Hokkaido University, Shirato, Hiroki Global, Station for, Quantum Biomedical Science, Engineering, Global Institute, for Cooperative Research, Education, Hokkaido University
Journal of Radiation Research, 59, suppl_1, i50, i57, 2018年03月01日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Evaluation of amnion-derived mesenchymal stem cells for treatment-resistant moderate Crohn’s disease: study protocol for a phase I/II, dual-centre, open-label, uncontrolled, dose–response trial
Otagiri, Shinsuke Department of Gastroenterology, Hepatology, Hokkaido, University Graduate School of, Medicine, Ohnishi, Shunsuke Department of Gastroenterology, Hepatology, Hokkaido, University Graduate School of, Medicine, Miura, Arisa Clinical Research, Medical Innovation Center, Hokkaido University, Hospital, Hayashi, Hiroshi Clinical Research, Medical Innovation Center, Hokkaido University Hospital, Kumagai, Izumi Clinical Research, Medical Innovation Center, Hokkaido University Hospital, M. Ito, Yoichi Department, of Biostatistics, Hokkaido University, Graduate School of Medicine, Katsurada, Takehiko Department of Gastroenterology, Hepatology, Hokkaido, University, Graduate School of, Medicine, Nakamura, Shiro Department of Inflammatory Bowel Disease, Hyogo College of, Medicine, Okamoto, Rika Center, for Clinical Research, Education, Hyogo College, of, Medicine, Yamahara, Kenichi Department of Transfusion Medicine, Cell Therapy, Hyogo College of, Medicine, Cho, Kyu Yong, Clinical Research, Medical Innovation Center, Hokkaido University Hospital, Isoe, Toshiyuki Clinical Research, Medical Innovation Center, Hokkaido University Hospital, Sato, Norihiro Clinical Research, Medical Innovation Center, Hokkaido University Hospital, Sakamoto, Naoya Department of Gastroenterology, Hepatology, Hokkaido, University, Graduate School of Medicine
BMJ Open Gastroenterology, 5, 1, e000206, 2018年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Serum periostin is associated with body mass index and allergic rhinitis in healthy and asthmatic subjects
Hirokazu Kimura, Satoshi Konno, Hironi Makita, Natsuko Taniguchi, Hiroki Kimura, Houman Goudarzi, Kaoruko Shimizu, Masaru Suzuki, Noriharu Shijubo, Katsunori Shigehara, Junya Ono, Kenji Izuhara, Yoichi Minagawa Ito, Masaharu Nishimura
Allergology International, 67, 3, 357, 63, 2018年, ［査読有り］
英語, 研究論文（学術雑誌）

Measurement of endometrial thickness in premenopausal women in office gynecology
Hiroshi Tsuda, Yoichi M. Ito, Yukiharu Todo, Takahiro Iba, Keiichi Tasaka, Yuji Sutou, Kozo Hirai, Koichiro Dozono, Yoshifusa Dobashi, Mami Manabe, Tomomi Sakamoto, Ritsu Yamamoto, Katsufumi Ueda, Moe Akatsuka, Yasuhiko Kiyozuka, Nobutaka Nagai, Manami Imai, Koji Kobiki, Hiromasa Fujita, Hiroaki Itamochi, Takafumi Oshita, Takahiro Kawarada, Masayuki Hatae, Yoshihito Yokoyama
Reproductive Medicine and Biology, 17, 1, 29, 35, 2018年01月01日, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Distinct phenotypes of smokers with fixed airflow limitation identified by cluster analysis of severe asthma
Satoshi Konno, for the HiCARAT Investigators, Natsuko Taniguchi, Hironi Makita, Yuji Nakamaru, Kaoruko Shimizu, Noriharu Shijubo, Satoshi Fuke, Kimihiro Takeyabu, Mitsuru Oguri, Hirokazu Kimura, Yukiko Maeda, Masaru Suzuki, Katsura Nagai, Yoichi M. Ito, Sally E. Wenzel, Masaharu Nishimura, Akira Isada, Takeshi Hattori, Kenichi Shimizu, Takayuki Yoshida, Kentaro Nagaoka, Shinji Nakane, Yoshiyuki Saito, Tsukasa Sasaki, Hideko Honda, Miho Deai, Ayako Muramoto, Natsumi Kudo, Nozomi Sato, Masanobu Suzuki, Hiroshi Saito, Tetsuya Kojima, Shiho Ichimura, Takashi Choji, Motoko Kobayashi, Akihiko Ishikuro, Yoshihiro Ohtsuka, Fumihiro Honmura, Yasushi Akiyama, Toshiyuki Harada, Akira Kamimura, Norio Tashiro, Hiroshi Mikami, Mistuhide Ohmichi, Yoshitaka Sugawara, Toshiki Takahashi, Makoto Yamamoto, Kei Takamura, Yoshio Tokuchi, Yuji Inoue, Katsunori Shigehara, Hideaki Ukita, Kouki Kikuchi, Hiroyuki Koba, Kyuichirou Sekine, Tsuyoshi Nakano, Yoshihiro Ohata, Noritomo Ohnuma, Fumihiko Sato, Hiroyuki Taguchi, Hiroyuki Sugawara, Osamu Honjo, Seiya Togashi, Hirotaka Nishikiori, Junya Kitada, Masaru Fujii, Eiji Shibuya, Hiroshi Tanaka, Yoshihiro Okamoto, Hiromitu Hiroumi, Kazuhiko Watanabe
Annals of the American Thoracic Society, 15, 1, 33, 41, American Thoracic Society, 2018年01月01日, ［査読有り］
英語, 研究論文（学術雑誌）

The effect of duration of illness and antipsychotics on subcortical volumes in schizophrenia: Analysis of 778 subjects.
Naoki Hashimoto, Yoichi M Ito, Naohiro Okada, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Noriko Kudo, Ariyoshi Takemura, Shuraku Son, Hisashi Narita, Maeri Yamamoto, Khin Khin Tha, Asuka Katsuki, Kazutaka Ohi, Fumio Yamashita, Shinsuke Koike, Tsutomu Takahashi, Kiyotaka Nemoto, Masaki Fukunaga, Toshiaki Onitsuka, Yoshiyuki Watanabe, Hidenori Yamasue, Michio Suzuki, Kiyoto Kasai, Ichiro Kusumi, Ryota Hashimoto
NeuroImage. Clinical, 17, 563, 569, 2018年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Performance of computed tomography-derived pulmonary vasculature metrics in the diagnosis and haemodynamic assessment of pulmonary arterial hypertension
Kaoruko Shimizu, Ichizo Tsujino, Takahiro Sato, Ayako Sugimoto, Toshitaka Nakaya, Taku Watanabe, Hiroshi Ohira, Yoichi M. Ito, Masaharu Nishimura
EUROPEAN JOURNAL OF RADIOLOGY, 96, 31, 38, 2017年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Regional interaction between myocardial sympathetic denervation, contractile dysfunction, and fibrosis in heart failure with preserved ejection fraction: 11C-hydroxyephedrine PET study.
Tadao Aikawa, Masanao Naya, Masahiko Obara, Noriko Oyama-Manabe, Osamu Manabe, Keiichi Magota, Yoichi M Ito, Chietsugu Katoh, Nagara Tamaki
European journal of nuclear medicine and molecular imaging, 44, 11, 1897, 1905, 2017年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Delayed Gastric Emptying in Side-to-Side Gastrojejunostomy in Pancreaticoduodenectomy: Result of a Propensity Score Matching
Akio Tsutaho, Toru Nakamura, Toshimichi Asano, Keisuke Okamura, Takahiro Tsuchikawa, Takehiro Noji, Yoshitsugu Nakanishi, Kimitaka Tanaka, Soichi Murakami, Yo Kurashima, Yuma Ebihara, Toshiaki Shichinohe, Yoichi M. Ito, Satoshi Hirano
JOURNAL OF GASTROINTESTINAL SURGERY, 21, 10, 1635, 1642, 2017年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

左室収縮が保持された心不全における11C-HED PETを用いた局所心筋交感神経分布の検討　　　　　　　　　　　　　　　
相川 忠夫, 納谷 昌直, 小原 雅彦, 真鍋 徳子, 真鍋 治, 小梁川 和宏, 孫田 恵一, 伊藤 陽一, 志賀 哲, 加藤 千恵次, 玉木 長良
核医学, 54, Suppl., S174, S174, (一社)日本核医学会, 2017年09月, ［査読有り］
日本語

Local relapse of nasopharyngeal cancer and Voxel-based analysis of FMISO uptake using PET with semiconductor detectors
Yukiko Nishikawa, Koichi Yasuda, Shozo Okamoto, Yoichi M. Ito, Rikiya Onimaru, Tohru Shiga, Kazuhiko Tsuchiya, Shiro Watanabe, Wataru Takeuchi, Yuji Kuge, Hao Peng, Nagara Tamaki, Hiroki Shirato
RADIATION ONCOLOGY, 12, 1, 148, 148, 2017年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Distinct Phenotypes of Smokers with Fixed Airflow Limitation Identified by Cluster Analysis of Severe Asthma.
Konno S, Taniguchi N, Makita H, Nakamaru Y, Shimizu K, Shijubo N, Fuke S, Takeyabu K, Oguri M, Kimura H, Maeda Y, Suzuki M, Nagai K, Ito YM, Wenzel SE, Nishimura M, HiCARAT Investigators
Annals of the American Thoracic Society, 15, 1, 33, 41, 2017年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Changes of Cerebral Oxygenation in Sequential Glenn and Fontan Procedures in the Same Children
Yasunori Yagi, Masataka Yamamoto, Hitoshi Saito, Toshihiro Mori, Yuji Morimoto, Takayoshi Oyasu, Tsuyoshi Tachibana, Yoichi M. Ito
PEDIATRIC CARDIOLOGY, 38, 6, 1215, 1219, 2017年08月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

日本人および米国人患者に対する膀胱全摘除術後周術期死亡予測ノモグラムの外的妥当性の検証
大澤 崇宏, 安部 崇重, 高田 徳容, 伊藤 陽一, 菊地 央, 宮島 直人, 土屋 邦彦, 丸山 覚, Lee Cheryl T., Morgan Todd M., 村井 祥代, 篠原 信雄
泌尿器外科, 30, 7, 1207, 1207, 医学図書出版(株), 2017年07月
日本語

Development of a screening tool to predict malnutrition among children under two years old in Zambia
Junko Hasegawa, Yoichi M. Ito, Taro Yamauchi
GLOBAL HEALTH ACTION, 10, 1, 2017年07月, ［査読有り］
英語, 研究論文（学術雑誌）

A registry study of multiple system atrophy in Hokkaido, Japan: HoRC-MSA Project 2014-16
M. Matsushima, K. Sakushima, I. Yabe, Y. Kanatani, Y. Ito, T. Matsuoka, T. Katayama, H. Uesugi, K. Sako, A. Takei, M. Mori, S. Shimohama, N. Sato, S. Kikuchi, H. Sasaki
MOVEMENT DISORDERS, 32, 2017年06月, ［査読有り］
英語

Association between suicide-related ideations and affective temperaments in the Japanese general adult population
Nobuyuki Mitsui, Yukiei Nakai, Takeshi Inoue, Niki Udo, Kan Kitagawa, Yumi Wakatsuki, Rie Kameyama, Atsuhito Toyomaki, Yoichi M. Ito, Yuji Kitaichi, Shin Nakagawa, Ichiro Kusumi
PLOS ONE, 12, 6, e0179952, 2017年06月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Lifetime attributable risk of radiation-induced secondary cancer from proton beam therapy compared with that of intensity-modulated X-ray therapy in randomly sampled pediatric cancer patients
Masaya Tamura, Hideyuki Sakurai, Masashi Mizumoto, Satoshi Kamizawa, Shigeyuki Murayama, Haruo Yamashita, Seishin Takao, Ryusuke Suzuki, Hiroki Shirato, Yoichi M. Ito
JOURNAL OF RADIATION RESEARCH, 58, 3, 363, 371, 2017年05月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

日本人および米国人患者に対する膀胱全摘除術後周術期死亡予測ノモグラムの外的妥当性の検証　　　　　　　　　　　　　　　
大澤 崇宏, 安部 崇重, 高田 徳容, 伊藤 陽一, 菊地 央, 宮島 直人, 土屋 邦彦, 丸山 覚, 村井 祥代, りー・しぇりる, もるがん・とっど, 篠原 信雄
日本泌尿器科学会総会, 105回, OP14, 3, (一社)日本泌尿器科学会総会事務局, 2017年04月
日本語

腸管利用尿路変更膀胱全摘除術における術前因子と周術期重度合併症の関連　　　　　　　　　　　　　　　
山田 修平, 大澤 崇宏, 安部 崇重, 高田 徳容, 伊藤 陽一, 菊池 央, 宮島 直人, 丸山 覚, 土屋 邦彦, 村井 祥代, 篠原 信雄
日本泌尿器科学会総会, 105回, PP11, 08, (一社)日本泌尿器科学会総会事務局, 2017年04月
日本語

Hypoxic glucose metabolism in glioblastoma as a potential prognostic factor.
Takuya Toyonaga, Shigeru Yamaguchi, Kenji Hirata, Kentaro Kobayashi, Osamu Manabe, Shiro Watanabe, Shunsuke Terasaka, Hiroyuki Kobayashi, Naoya Hattori, Tohru Shiga, Yuji Kuge, Shinya Tanaka, Yoichi M Ito, Nagara Tamaki
European journal of nuclear medicine and molecular imaging, 44, 4, 611, 619, 2017年04月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Analysis of inter- and intra fractional partial bladder wall movement using implanted fiducial markers
Kentaro Nishioka, Shinichi Shimizu, Nobuo Shinohara, Yoichi M. Ito, Takashige Abe, Satoru Maruyama, Norio Katoh, Rumiko Kinoshita, Takayuki Hashimoto, Naoki Miyamoto, Rikiya Onimaru, Hiroki Shirato
RADIATION ONCOLOGY, 12, 1, 44, 44, 2017年03月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Reduction of HbA1c levels by fucoxanthin-enriched akamoku oil possibly involves the thrifty allele of uncoupling protein 1 (UCP1): A randomised controlled trial in normal-weight and obese Japanese adults
Nana Mikami, Masashi Hosokawa, Kazuo Miyashita, Hitoshi Sohma, Yoichi M. Ito, Yasuo Kokai
Journal of Nutritional Science, 6, e5, 2017年02月14日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Psychometric properties of the Global Operative Assessment of Laparoscopic Skills (GOALS) using item response theory
Yusuke Watanabe, Amin Madani, Yoichi M. Ito, Elif Bilgic, Katherine M. McKendy, Liane S. Feldman, Gerald M. Fried, Melina C. Vassiliou
AMERICAN JOURNAL OF SURGERY, 213, 2, 273, 276, 2017年02月, ［査読有り］, ［国際共著］, ［国際誌］
英語, 研究論文（学術雑誌）

Accuracy of echocardiographic indices for serial monitoring of right ventricular systolic function in patients with precapillary pulmonary hypertension.
Sato T, Tsujino I, Ohira H, Oyama-Manabe N, Ito YM, Takashina C, Watanabe T, Nishimura M
PloS one, 12, 11, e0187806, 2017年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Impact of Real-Time Image Gating on Spot Scanning Proton Therapy for Lung Tumors: A Simulation Study.
Kanehira T, Matsuura T, Takao S, Matsuzaki Y, Fujii Y, Fujii T, Ito YM, Miyamoto N, Inoue T, Katoh N, Shimizu S, Umegaki K, Shirato H
International journal of radiation oncology, biology, physics, 97, 1, 173, 181, 2017年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia
Umma Habiba, Kyoko Hida, Tetsuya Kitamura, Aya Yanagawa Matsuda, Fumihiro Higashino, Yoichi M. Ito, Yoichi Ohiro, Yasunori Totsuka, Masanobu Shindoh
ONCOLOGY LETTERS, 13, 1, 321, 328, 2017年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Development of a screening tool to predict malnutrition among children under two years old in Zambia
Junko Hasegawa, Yoichi M Ito, Taro Yamauchi
Global Health Action, 10, 1, 1339981, 1339981, Informa UK Limited, 2017年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Maternal and child undernutrition is an important issue, particularly in low- and middle-income countries. Children at high risk of malnutrition should be prioritized to receive necessary interventions to minimize such risk. Several risk factors have been proposed; however, until now, there has been no appropriate evaluation method to identify these children. In sub-Saharan Africa, children commonly receive regular check-ups from community health workers. A simple and easy nutrition assessment method is therefore needed for use by semi-professional health workers. OBJECTIVES: The aim of this study was to develop and test a practical screening tool for community use in predicting growth stunting in children under two years in rural Zambia. METHODS: Field research was conducted from July to August 2014 in Southern Province, Zambia. Two hundred and sixty-four mother-child pairs participated in the study. Anthropometric measurements were performed on all children and mothers, and all mothers were interviewed. Risk factors for the screening test were estimated by using least absolute shrinkage and selection operator analysis. After re-evaluating all participants using the new screening tool, a receiver operating characteristic curve was drawn to set the cut-off value. Sensitivity and specificity were also calculated. RESULTS: The screening tool included age, weight-for-age Z-score status, birth weight, feeding status, history of sibling death, multiple birth, and maternal education level. The total score ranged from 0 to 22, and the cut-off value was eight. Sensitivity and specificity were 0.963 and 0.697 respectively. CONCLUSIONS: A screening tool was developed to predict children at high risk of malnutrition living in Zambia. Further longitudinal studies are needed to confirm the test's validity in detecting future stunting and to investigate the effectiveness of malnutrition treatment.

Lifetime attributable risk of radiation-induced secondary cancer from proton beam therapy compared with that of intensity-modulated X-ray therapy in randomly sampled pediatric cancer patients
Tamura,Masaya, Sakurai,Hideyuki, Mizumoto,Masashi, Kamizawa,Satoshi, Murayama,Shigeyuki, Yamashita,Haruo, Takao,Seishin, Suzuki,Ryusuke, Shirato,Hiroki, Ito,M. Yoichi
J Radiat Res, 58, 3, 363, 371, OXFORD UNIV PRESS, 2016年10月, ［査読有り］
英語, 研究論文（学術雑誌）, To investigate the amount that radiation-induced secondary cancer would be reduced by using proton beam therapy (PBT) in place of intensity-modulated X-ray therapy (IMXT) in pediatric patients, we analyzed lifetime attributable risk (LAR) as an in silico surrogate marker of the secondary cancer after these treatments. From 242 pediatric patients with cancers who were treated with PBT, 26 patients were selected by random sampling after stratification into four categories: (i) brain, head and neck, (ii) thoracic, (iii) abdominal, and (iv) whole craniospinal (WCNS) irradiation. IMXT was replanned using the same computed tomography and region of interest. Using the dose-volume histograms (DVHs) of PBT and IMXT, the LARs of Schneider et al were calculated for the same patient. All the published dose-response models were tested for the organs at risk. Calculation of the LARs of PBT and IMXT based on the DVHs was feasible for all patients. The means ± standard deviations of the cumulative LAR difference between PBT and IMXT for the four categories were (i) 1.02 ± 0.52% (n = 7, P = 0.0021), (ii) 23.3 ± 17.2% (n = 8, P = 0.0065), (iii) 16.6 ± 19.9% (n = 8, P = 0.0497)

Computed tomography (CT)-assessed bronchodilation induced by inhaled indacaterol and glycopyrronium/indacaterol in COPD
Kaoruko Shimizu, Ruriko Seto, Hironi Makita, Masaru Suzuki, Satoshi Konno, Yoichi M. Ito, Rie Kanda, Emiko Ogawa, Yasutaka Nakano, Masaharu Nishimura
RESPIRATORY MEDICINE, 119, 70, 77, 2016年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Comprehensive assessment of impaired peripheral and coronary artery endothelial functions in smokers using brachial artery ultrasound and oxygen-15-labeled water PET.
Noriki Ochi, Keiichiro Yoshinaga, Yoichi M Ito, Yuuki Tomiyama, Mamiko Inoue, Mutsumi Nishida, Osamu Manabe, Hitoshi Shibuya, Chikara Shimizu, Eriko Suzuki, Satoshi Fujii, Chietsugu Katoh, Nagara Tamaki
Journal of cardiology, 68, 4, 316, 23, 2016年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Correlation analysis between change in thoracic kyphosis and multilevel facetectomy and screw density in main thoracic adolescent idiopathic scoliosis surgery
Hideki Sudo, Yuichiro Abe, Terufumi Kokabu, Manabu Ito, Kuniyoshi Abumi, Yoichi M. Ito, Norimasa Iwasaki
SPINE JOURNAL, 16, 9, 1049, 1054, 2016年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Effects of prenatal exposure to perfluoroalkyl acids on prevalence ofallergic diseases among 4-year-old children
Houman Goudarzi, Chihiro Miyashita, Emiko Okada, Ikuko Kashino, Sumitaka Kobayashi, Chi-Jen Chen, Sachiko Ito, Atsuko Araki, Hideyuki Matsuura, Yoichi M. Ito, Reiko Kishi
ENVIRONMENT INTERNATIONAL, 94, 124, 132, 2016年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

NTCP modeling analysis of acute hematologic toxicity in whole pelvic radiation therapy for gynecologic malignancies - A dosimetric comparison of IMRT and spot-scanning proton therapy (SSPT)
Takaaki Yoshimura, Rumiko Kinoshita, Shunsuke Onodera, Chie Toramatsu, Ryusuke Suzuki, Yoichi M. Ito, Seishin Takao, Taeko Matsuura, Yuka Matsuzaki, Kikuo Umegaki, Hiroki Shirato, Shinichi Shimizu
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 32, 9, 1095, 1102, 2016年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

In Vivo Mouse Intervertebral Disc Degeneration Model Based on a New Histological Classification
Takashi Ohnishi, Hideki Sudo, Koji Iwasaki, Takeru Tsujimoto, Yoichi M. Ito, Norimasa Iwasaki
PLOS ONE, 11, 8, e0160486, 2016年08月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Effects of Multilevel Facetectomy and Screw Density on Postoperative Changes in Spinal Rod Contour in Thoracic Adolescent Idiopathic Scoliosis Surgery
Terufumi Kokabu, Hideki Sudo, Yuichiro Abe, Manabu Ito, Yoichi M. Ito, Norimasa Iwasaki
PLOS ONE, 11, 8, e0161906, 2016年08月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Comparison of conventional ultrasonography and ultrasonography-computed tomography fusion imaging for target identification using digital/real hybrid phantoms: a preliminary study
Takeshi Soyama, Yusuke Sakuhara, Kohsuke Kudo, Daisuke Abo, Jeff Wang, Yoichi M. Ito, Yu Hasegawa, Hiroki Shirato
JOURNAL OF MEDICAL ULTRASONICS, 43, 3, 327, 335, 2016年07月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

上咽頭癌再発例におけるFMISO-PETと放射線治療に関する解析　　　　　　　　　　　　　　　
安田 耕一, 西川 由記子, 岡本 祥三, 伊藤 陽一, 土屋 和彦, 志賀 哲, 鬼丸 力也, 久下 裕司, 玉木 長良, 白土 博樹
頭頸部癌, 42, 2, 158, 158, (一社)日本頭頸部癌学会, 2016年05月
日本語

Comparison of students' encountered diseases and available diseases at clerkship sites by exploratory multivariate analysis: Are encountered diseases predictable?
Kikuko Taketomi, Makoto Kikukawa, Yoichi M. Ito, Akihiro Yamaoka, Junji Otaki, Motofumi Yoshida
MEDICAL TEACHER, 38, 4, 395, 403, 2016年04月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Comparison of students' encountered diseases and available diseases at clerkship sites by exploratory multivariate analysis: Are encountered diseases predictable? (vol 38, pg 395, 2016)
Kikuko Taketomi, Makoto Kikukawa, Yoichi M. Ito, Akihiro Yamaoka, Junji Otaki, Motofumi Yoshida
MEDICAL TEACHER, 38, 4, 395, 403, 2016年04月, ［査読有り］
英語

Nepalese undergraduate nursing students' perceptions of the clinical learning environment, supervision and nurse teachers: A questionnaire survey
Bijeta Nepal, Kikuko Taketomi, Yoichi M. Ito, Masashi Kohanawa, Hidenobu Kawabata, Michiko Tanaka, Junji Otaki
NURSE EDUCATION TODAY, 39, 181, 188, 2016年04月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

The clinical trial on the safety and effectiveness of the photodynamic diagnosis of non-muscle-invasive bladder cancer using fluorescent light-guided cystoscopy after oral administration of 5-aminolevulinic acid (5-ALA)
Keiji Inoue, Hideyasu Matsuyama, Kiyohide Fujimoto, Yoshihiko Hirao, Hironobu Watanabe, Seiichiro Ozono, Masafumi Oyama, Munehisa Ueno, Yoshiki Sugimura, Hiroaki Shiina, Hiromitsu Mimata, Haruhito Azuma, Yasushi Nagase, Akio Matsubara, Yoichi M. Ito, Taro Shuin
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 13, 91, 96, 2016年03月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Association between Smoking Status and Obesity in a Nationwide Survey of Japanese Adults
Taku Watanabe, Ichizo Tsujino, Satoshi Konno, Yoichi M. Ito, Chisa Takashina, Takahiro Sato, Akira Isada, Hiroshi Ohira, Yoshinori Ohtsuka, Yuma Fukutomi, Hiroyuki Nakamura, Yukio Kawagishi, Chiharu Okada, Nobuyuki Hizawa, Masami Taniguchi, Akira Akasawa, Masaharu Nishimura
PLOS ONE, 11, 3, e0148926, 2016年03月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

椎体IMRTとその精度に関する研究　　　　　　　　　　　　　　　
安田 耕一, 清水 伸一, 橋本 孝之, Sutherland Ken, 白土 博樹, 土屋 和彦, 加藤 徳雄, 鬼丸 力也, 木下 留美子, 井上 哲也, 西岡 健太郎, 西川 由記子, 森 崇, 原田 慶一, 原田 八重, 鈴木 隆介, 寅松 千枝, 松浦 妙子, 高尾 聖心, 宮本 直樹, 伊藤 陽一
Japanese Journal of Radiology, 34, Suppl., 5, 5, (公社)日本医学放射線学会, 2016年02月
日本語

Reliable assessment of operative performance
Elif Bilgic, Yusuke Watanabe, Katherine McKendy, Amani Munshi, Yoichi M. Ito, Gerald M. Fried, Liane S. Feldman, Melina C. Vassiliou
AMERICAN JOURNAL OF SURGERY, 211, 2, 426, 430, 2016年02月, ［査読有り］, ［国際共著］, ［国際誌］
英語, 研究論文（学術雑誌）

Evaluation of the motion of lung tumors during stereotactic body radiation therapy (SBRT) with four-dimensional computed tomography (4DCT) using real-time tumor-tracking radiotherapy system (RTRT)
Keiichi Harada, Norio Katoh, Ryusuke Suzuki, Yoichi M. Ito, Shinichi Shimizu, Rikiya Onimaru, Tetsuya Inoue, Naoki Miyamoto, Hiroki Shirato
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 32, 2, 305, 311, 2016年02月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

The Association between Prenatal Yoga and the Administration of Ritodrine Hydrochloride during Pregnancy: An Adjunct Study of the Japan Environment and Children's Study.
Kawanishi Y, Saijo Y, Yoshioka E, Nakagi Y, Yoshida T, Miyamoto T, Sengoku K, Ito Y, Miyashita C, Araki A, Kishi R
PloS one, 11, 6, e0158155, 2016年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, INTRODUCTION: While the beneficial effects of prenatal yoga have been reported in recent years, little is known about its effectiveness in pregnant Japanese women. Despite several adverse effects, ritodrine hydrochloride is frequently prescribed to suppress preterm labor in Japan, and its usage may therefore indicate cases of preterm labor. This study aimed to clarify the association between prenatal yoga and ritodrine hydrochloride use during pregnancy. METHODS: An observational study was conducted as an adjunct study by the Hokkaido unit of the Japan Environment and Children's Study. Information on prenatal yoga practice was collected using a self-questionnaire between March 21, 2012, and July 7, 2015, targeting women who had recently delivered. Ritodrine hydrochloride use was identified from medical records. A total of 2,692 women were analyzed using logistic regression models that adjusted for possible confounders. RESULTS: There were 567 (21.1%) women who practiced prenatal yoga, which was associated with a lower risk of ritodrine hydrochloride use (adjusted odds ratio [OR] 0.77; 95% CI 0.61-0.98). This was especially evident in women with a total practice duration that exceeded 900 minutes throughout their pregnancy (adjusted OR 0.54; 95% CI 0.38-0.76). A sensitivity analysis that excluded patients with threatened abortion during the study period produced similar results. CONCLUSIONS: Prenatal yoga was associated with a lower risk of ritodrine hydrochloride use, particularly in women with more than 900 minutes of practice time over the course of their pregnancy. Prenatal yoga may be a beneficial option for pregnant women in the selection of alternative therapies.

The effect of APOE ϵ4 allele on brain perfusion SPECT in late onset Alzheimer's disease by an automated program, 3DSRT
Seiju Kobayashi, Takao Ishii, Masaru Tateno, Hitoshi Sohma, Yasuo Kokai, Yoichi M. Ito, Tomo Iwamoto, Kengo Furuse, Hanako Tsujino, Hidetoshi Morii, Wataru Ukai, Eri Hashimoto, Kumiko Utsumi, Chiaki Kawanishi
Neuropsychiatry, 6, 2, 55, 63, Future Medicine Ltd., 2016年, ［査読有り］
英語, 研究論文（学術雑誌）

Characteristics of Diffusional kurtosis in chronic ischemia of adult Moyamoya disease: Comparing Diffusional kurtosis and diffusion tensor imaging
Kazumata K, Tha K.K, Narita H, Ito Y.M, Shichinohe H, Ito M, Uchino H, Abumiya T
American Journal of Neuroradiology, 37, 8, 1432, 1439, 2016年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Associations among the plasma amino acid profile, obesity, and glucose metabolism in Japanese adults with normal glucose tolerance
Chisa Takashina, Ichizo Tsujino, Taku Watanabe, Shinji Sakaue, Daisuke Ikeda, Asuka Yamada, Takahiro Sato, Hiroshi Ohira, Yoshinori Otsuka, Noriko Oyama-Manabe, Yoichi M. Ito, Masaharu Nishimura
NUTRITION & METABOLISM, 13, 5, 5, 2016年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Distinct phenotypes of cigarette smokers identified by cluster analysis of patients with severe asthma
Satoshi Konno, Natsuko Taniguchi, Hironi Makita, Yuji Nakamaru, Kaoruko Shimizu, Noriharu Shijubo, Satoshi Fuke, Kimihiro Takeyabu, Mitsuru Oguri, Hirokazu Kimura, Yukiko Maeda, Masaru Suzuki, Katsura Nagai, Yoichi M. Ito, Sally E. Wenzel, Masaharu Nishimura
Annals of the American Thoracic Society, 12, 12, 1771, 1780, American Thoracic Society, 2015年12月01日, ［査読有り］
英語, 研究論文（学術雑誌）

Distinct Phenotypes of Cigarette Smokers Identified by Cluster Analysis of Patients with Severe Asthma.
Konno S, Taniguchi N, Makita H, Nakamaru Y, Shimizu K, Shijubo N, Fuke S, Takeyabu K, Oguri M, Kimura H, Maeda Y, Suzuki M, Nagai K, Ito YM, Wenzel SE, Nishimura M, Hi-CARAT Investigators
Annals of the American Thoracic Society, 12, 12, 1771, 1780, 2015年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Quantitative evaluation of gait ataxia by accelerometers
Shinichi Shirai, Ichiro Yabe, Masaald Matsushima, Yoichi M. Ito, Mitsuru Yoneyama, Hidenao Sasaki
JOURNAL OF THE NEUROLOGICAL SCIENCES, 358, 1-2, 253, 258, 2015年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Reliable Assessment of Performance in Surgery: A Practical Approach to Generalizability Theory
Elif Bilgic, Yusuke Watanabe, Katherine M. McKendy, Yoichi Ito, Melina C. Vassiliou
JOURNAL OF SURGICAL EDUCATION, 72, 5, 774, 775, 2015年09月, ［査読有り］, ［国際共著］
英語

Regional bronchodilator response assessed by computed tomography in chronic obstructive pulmonary disease
Kaoruko Shimizu, Hironi Makita, Masaru Hasegawa, Hirokazu Kimura, Satoshi Fuke, Katsura Nagai, Takayuki Yoshida, Masaru Suzuki, Satoshi Konno, Yoichi M. Ito, Masaharu Nishimura
EUROPEAN JOURNAL OF RADIOLOGY, 84, 6, 1196, 1201, 2015年06月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

被験者組入れ不良により中止された介入研究の失敗要因分析 事例検討
佐久嶋 研, 堀江 奈穂, 天野 虎次, 茂木 祐子, 西村 千佳子, 重松 明男, 大庭 幸治, 伊藤 陽一, 佐藤 典宏
薬理と治療, 43, Suppl.1, s94, s98, ライフサイエンス出版(株), 2015年05月
日本語

FDG PET performed at thyroid remnant ablation has a higher predictive value for long-term survival of high-risk patients with well-differentiated thyroid cancer than radioiodine uptake.
Florian C Gaertner, Shozo Okamoto, Tohru Shiga, Yoichi M Ito, Yuko Uchiyama, Osamu Manabe, Naoya Hattori, Nagara Tamaki
Clinical nuclear medicine, 40, 5, 378, 83, 2015年05月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients
Katsura Nagai, Hironi Makita, Masaru Suzuki, Kaoruko Shimizu, Satoshi Konno, Yoichi M Ito, Masaharu Nishimura, On behalf of the Hokkaido COPD Cohort Study Investigators, Yoshikazu Kawakami, Youichi Nishiura, Hiroshi Saito, Tetsuya Kojima, Takeshi Igarashi, Kiyonobu Kimura, Ikuo Nakano, Moto Katabami, Kouichi Itabashi, Kiyoshi Morikawa, Seiichi Tagami, Yoshihiro Otsuka, Rika Sato, Junichiro Kojima, Shinji Nigawara, Takashi Morioka, Ichiro Sakai, Hiroshi Yamamoto, Shigeaki Ogura, Kenji Akie, Fumihiro Honmura, Shinichi Kusudou, Hiroshi Izumi, Kensuke Baba, Hiroki Goya, Tsuyoshi Nakano, Kimihiro Takeyabu, Yasushi Akiyama, Fujiya Kishi, Akihide Ito, Michihiro Fujino, Masashi Ohe, Toshiyuki Harada, Akira Kamimura, Nobuyuki Hakuma, Noriaki Sukou, Kazuo Takaoka, Isamu Doi, Atsushi Ishimine, Ryouji Nakano, Yasushi Hasegawa, Yasuyuki Nasuhara, Tomoko Betsuyaku, Kunio Hamada, Yoko Ito, Motoko Kobayashi, Takeshi Hosokawa, Satoshi Fuke, Masaru Hasegawa, Nao Odajima, Chinatsu Moriyama, Takayuki Yoshida, Takashi Inomata, Kanako Maki, Eiji Shibuya, Tsukasa Sasaki, Katsuaki Nitta, Masafumi Yamamoto, Shigetaka Mizuno, Kenji Miyamoto, Nobuyuki Hizawa
International Journal of COPD, 10, 745, 757, Dove Medical Press Ltd., 2015年04月13日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Right atrial volume and reservoir function are novel independent predictors of clinical worsening in patients with pulmonary hypertension
Takahiro Sato, Ichizo Tsujino, Hiroshi Ohira, Noriko Oyama-Manabe, Yoichi M. Ito, Asuka Yamada, Daisuke Ikeda, Taku Watanabe, Masaharu Nishimura
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 34, 3, 414, 423, 2015年03月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Effect of age difference of cerebral oxygen saturation to predict early outcome in pediatric cardiac surgery for ventricular septal defect.
Yasunori Yagi, Masataka Yamamoto, Hitoshi Saito, Toshihiro Mori, Yuji Morimoto, Takayoshi Oyasu, Tsuyoshi Tachibana, Yoichi M Ito
Circulation Control, 36, 2, 106, 110, Japan Society of Circulation Control in Medicine, 2015年, ［査読有り］
英語, 研究論文（学術雑誌）

Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients
Katsura Nagai, Hironi Makita, Masaru Suzuki, Kaoruko Shimizu, Satoshi Konno, Yoichi M. Ito, Masaharu Nishimura
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 10, 745, 757, 2015年, ［査読有り］
英語, 研究論文（学術雑誌）

呼吸不全に関する調査研究 酢酸PETによる肺高血圧症患者の右室エネルギー代謝に関する研究
西村正治, 吉永恵一郎, 大平洋, 辻野一三, 真鍋徳子, MIELNICZUK L, BEANLANDS R S B, 加藤千恵次, 葛西克彦, 真鍋治, 佐藤隆博, 藤井聡, 伊藤陽一, 富山勇輝, 玉木長良
呼吸不全に関する調査研究 平成26年度 総括・分担研究報告書, 257‐259, 2015年
日本語

Exploration of failure causes of an incomplete clinical trial in enrollment: A case study
Sakushima K, Horie N, Amano T, Mogi Y, Nishimura C, Shigematsu A, Oba K, Ito Y.M, Sato N
Japanese Pharmacology and Therapeutics, 43, s94, s98, 2015年, ［査読有り］

Time trend of injection drug errors before and after implementation of bar-code verification system
Ken Sakushima, Reona Umeki, Akira Endoh, Yoichi M. Ito, Yasuyuki Nasuhara
TECHNOLOGY AND HEALTH CARE, 23, 3, 267, 274, 2015年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Effects and safety of ¹³¹I-metaiodobenzylguanidine (MIBG) radiotherapy in malignant neuroendocrine tumors: results from a multicenter observational registry.
Yoshinaga K, Oriuchi N, Wakabayashi H, Tomiyama Y, Jinguji M, Higuchi T, Kayano D, Fukuoka M, Inaki A, Toratani A, Okamoto S, Shiga T, Ito YM, Nakajo M, Nakajo M, Kinuya S, Drafting Committee, for Guidelines on Internal Radiotherapy with, I-MIBG, Japanese Society of Nuclear Medicine in, Oncology, Imunology, Japanese Society of, Nuclear Medicine
Endocrine journal, 61, 12, 1171, 1180, 2014年12月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Current Practice in Japan for the Prevention and Treatment of Missing Data in Confirmatory Clinical Trials: A Survey of Japanese and Foreign Pharmaceutical Manufacturers
Shiro Tanaka, Satoru Fukinbara, Satoru Tsuchiya, Hideki Suganami, Yoichi M. Ito
THERAPEUTIC INNOVATION & REGULATORY SCIENCE, 48, 6, 717, 723, 2014年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Prone-position acquisition of myocardial (123)I-metaiodobenzylguanidine (MIBG) SPECT reveals regional uptake similar to that found using (11)C-hydroxyephedrine PET/CT.
Keiichiro Yoshinaga, Yuuki Tomiyama, Osamu Manabe, Katsuhiko Kasai, Chietsugu Katoh, Kenichi Magota, Eriko Suzuki, Ken-Ichi Nishijima, Yuji Kuge, Yoichi M Ito, Nagara Tamaki
Annals of nuclear medicine, 28, 8, 761, 9, 2014年10月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Simultaneous Analysis of the Gene Expression Profiles of Cancer and Stromal Cells in Endometrial Cancer
Yoko Iguchi, Yoichi M. Ito, Fumio Kataoka, Hiroyuki Nomura, Hideo Tanaka, Tatsuyuki Chiyoda, Shiho Hashimoto, Sadako Nishimura, Masashi Takano, Wataru Yamagami, Nobuyuki Susumu, Daisuke Aoki, Hiroshi Tsuda
GENES CHROMOSOMES & CANCER, 53, 9, 725, 737, 2014年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Distinct Molecular Features of Different Macroscopic Subtypes of Colorectal Neoplasms
Kenichi Konda, Kazuo Konishi, Toshiko Yamochi, Yoichi M. Ito, Hisako Nozawa, Masayuki Tojo, Kensuke Shinmura, Mari Kogo, Atsushi Katagiri, Yutaro Kubota, Takashi Muramoto, Yuichiro Yano, Yoshiya Kobayashi, Toshihiro Kihara, Teppei Tagawa, Reiko Makino, Masafumi Takimoto, Michio Imawari, Hitoshi Yoshida
PLOS ONE, 9, 8, e103822, 2014年08月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Attenuated right ventricular energetics evaluated using ¹¹C-acetate PET in patients with pulmonary hypertension.
Yoshinaga K, Ohira H, Tsujino I, Oyama-Manabe N, Mielniczuk L, Beanlands RS, Katoh C, Kasai K, Manabe O, Sato T, Fujii S, Ito YM, Tomiyama Y, Nishimura M, Tamaki N
European journal of nuclear medicine and molecular imaging, 41, 6, 1240, 50, 2014年06月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

デジタル/シミュレーターハイブリッドファントムの開発とUS-CT Fusion Imagingのバリデーション　　　　　　　　　　　　　　　
曽山 武士, 作原 祐介, 阿保 大介, Wang Jeff, 伊藤 陽一, 長谷川 悠, 工藤 與亮, 白土 博樹
IVR: Interventional Radiology, 29, Suppl., 200, 200, (一社)日本インターベンショナルラジオロジー学会, 2014年05月
日本語

Clinical features and determinants of COPD exacerbation in the Hokkaido COPD cohort study
Masaru Suzuki, Hironi Makita, Yoichi M. Ito, Katsura Nagai, Satoshi Konno, Masaharu Nishimura
EUROPEAN RESPIRATORY JOURNAL, 43, 5, 1289, 1297, 2014年05月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

The effects of a Gly16Arg ADRB2 polymorphism on responses to salmeterol or montelukast in Japanese patients with mild persistent asthma
Satoshi Konno, Nobuyuki Hizawa, Hironi Makita, Kaoruko Shimizu, Tohru Sakamoto, Fumio Kokubu, Takefumi Saito, Takeo Endo, Hiroki Ninomiya, Hiroaki Iijima, Norihiro Kaneko, Yoichi M. Ito, Masaharu Nishimura
PHARMACOGENETICS AND GENOMICS, 24, 5, 246, 255, 2014年05月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Prognostic Factors for Survival in Patients with High-Grade Meningioma and Recurrence-Risk Stratification for Application of Radiotherapy
Shigeru Yamaguchi, Shunsuke Terasaka, Hiroyuki Kobayashi, Katsuyuki Asaoka, Hiroaki Motegi, Hiroshi Nishihara, Hiromi Kanno, Rikiya Onimaru, Yoichi M. Ito, Hiroki Shirato, Kiyohiro Houkin
PLOS ONE, 9, 5, e97108, 2014年05月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Prospective phase II study of image-guided local boost using a real-time tumor-tracking radiotherapy (RTRT) system for locally advanced bladder cancer
Nishioka K, Shimizu S, Shinohara N, Ito Y. M, Abe T, Maruyama S, Kinoshita R, Harada K, Nishikawa N, Miyamoto N, Onimaru R, Shirato H
Jpn J Clin Oncol, 44, 1, 28, 35, 2014年, ［査読有り］

Prospective Phase II Study of Image-guided Local Boost Using a Real-time Tumor-tracking Radiotherapy (RTRT) System for Locally Advanced Bladder Cancer
Kentaro Nishioka, Shinichi Shimizu, Nobuo Shinohara, Yoichi M. Ito, Takashige Abe, Satoru Maruyama, Rumiko Kinoshita, Keiichi Harada, Noboru Nishikawa, Naoki Miyamoto, Rikiya Onimaru, Hiroki Shirato
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 44, 1, 28, 35, 2014年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Simple prediction of right ventricular ejection fraction using tricuspid annular plane systolic excursion in pulmonary hypertension
Takahiro Sato, Ichizo Tsujino, Noriko Oyama-Manabe, Hiroshi Ohira, Yoichi M. Ito, Hiroyuki Sugimori, Asuka Yamada, Chisa Takashina, Taku Watanabe, Masaharu Nishimura
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, 29, 8, 1799, 1805, 2013年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Dose-volume analysis for respiratory toxicity in intrathoracic esophagealcancer patients treated with definitive chemoradiotherapy using extended fields
Satoshi Tanabe, Miyako Myojin, Shinichi Shimizu, Masaharu Fujino, Hiroaki Takahashi, Hiroki Shirato, Yoichi M. Ito, Masayori Ishikawa, Masao Hosokawa
Journal of Radiation Research, 54, 6, 1085, 1094, 2013年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Clinical utility of high-throughput glycome analysis in patients with pancreatic cancer
Kazuhiro Nouso, Maho Amano, Yoichi M. Ito, Koji Miyahara, Yuki Morimoto, Hironari Kato, Koichiro Tsutsumi, Takeshi Tomoda, Naoki Yamamoto, Shinichiro Nakamura, Sayo Kobayashi, Kenji Kuwaki, Hiroaki Hagihara, Hideki Onishi, Yasuhiro Miyake, Fusao Ikeda, Hidenori Shiraha, Akinobu Takaki, Taku Nakahara, Shin-Ichiro Nishimura, Kazuhide Yamamoto
JOURNAL OF GASTROENTEROLOGY, 48, 10, 1171, 1179, 2013年10月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Elevated (18)F-fluorodeoxyglucose uptake in the interventricular septum is associated with atrioventricular block in patients with suspected cardiac involvement sarcoidosis.
Osamu Manabe, Hiroshi Ohira, Keiichiro Yoshinaga, Takahiro Sato, Alisa Klaipetch, Noriko Oyama-Manabe, Yoichi M Ito, Ichizo Tsujino, Masaharu Nishimura, Nagara Tamaki
European journal of nuclear medicine and molecular imaging, 40, 10, 1558, 66, 2013年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Temporal trends of perfluoroalkyl acids in plasma samples of pregnant women in Hokkaido, Japan, 2003-2011
Emiko Okada, Ikuko Kashino, Hideyuki Matsuura, Seiko Sasaki, Chihiro Miyashita, Jun Yamamoto, Tamiko Ikeno, Yoichi M. Ito, Toru Matsumura, Akiko Tamakoshi, Reiko Kishi
ENVIRONMENT INTERNATIONAL, 60, 89, 96, 2013年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Co-Overexpression of GEP100 and AMAP1 Proteins Correlates with Rapid Local Recurrence after Breast Conservative Therapy
Rumiko Kinoshita, Jin-Min Nam, Yoichi M. Ito, Kanako C. Hatanaka, Ari Hashimoto, Haruka Handa, Yutaro Otsuka, Shigeru Hashimoto, Yasuhito Onodera, Mitsuchika Hosoda, Shunsuke Onodera, Shinichi Shimizu, Shinya Tanaka, Hiroki Shirato, Mishie Tanino, Hisataka Sabe
PLOS ONE, 8, 10, e76791, 2013年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Right atrial volume and phasic function in pulmonary hypertension
Takahiro Sato, Ichizo Tsujino, Noriko Oyama-Manabe, Hiroshi Ohira, Yoichi M. Ito, Asuka Yamada, Daisuke Ikeda, Taku Watanabe, Masaharu Nishimura
INTERNATIONAL JOURNAL OF CARDIOLOGY, 168, 1, 420, 426, 2013年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Imaging characteristics of cardiac dominant diffuse large B-cell lymphoma demonstrated with MDCT and PET/CT.
Yasuka Kikuchi, Noriko Oyama-Manabe, Osamu Manabe, Masanao Naya, Yoichi M Ito, Kanako C Hatanaka, Hiroyuki Tsutsui, Satoshi Terae, Nagara Tamaki, Hiroki Shirato
European journal of nuclear medicine and molecular imaging, 40, 9, 1337, 44, 2013年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging.
Khin K Tha, Satoshi Terae, Shin Nakagawa, Takeshi Inoue, Nobuki Kitagawa, Yuki Kako, Yasuya Nakato, Kawser Akter Popy, Noriyuki Fujima, Yuri Zaitsu, Daisuke Yoshida, Yoichi M Ito, Tamaki Miyamoto, Tsukasa Koyama, Hiroki Shirato
Psychiatry research, 212, 3, 208, 15, 2013年06月30日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Diffusion tensor imaging (DTI) is considered to be able to non-invasively quantify white matter integrity. This study aimed to use DTI to evaluate white matter integrity in non-geriatric patients with major depressive disorder (MDD) who were free of antidepressant medication. DTI was performed on 19 non-geriatric patients with MDD, free of antidepressant medication, and 19 age-matched healthy subjects. Voxel-based and histogram analyses were used to compare fractional anisotropy (FA) and mean diffusivity (MD) values between the two groups, using two-sample t tests. The abnormal DTI indices, if any, were tested for correlation with disease duration and severity, using Pearson product-moment correlation analysis. Voxel-based analysis showed clusters with FA decrease at the bilateral frontal white matter, anterior limbs of internal capsule, cerebellum, left putamen and right thalamus of the patients. Histogram analysis revealed lower peak position of FA histograms in the patients. FA values of the abnormal clusters and peak positions of FA histograms of the patients exhibited moderate correlation with disease duration and severity. These results suggest the implication of frontal-subcortical circuits and cerebellum in MDD, and the potential utility of FA in evaluation of brain parenchymal integrity.

Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging
Khin K. Tha, Satoshi Terae, Shin Nakagawa, Takeshi Inoue, Nobuki Kitagawa, Yuki Kako, Yasuya Nakato, Kawser Akter Popy, Noriyuki Fujima, Yuri Zaitsu, Daisuke Yoshida, Yoichi M. Ito, Tamaki Miyamoto, Tsukasa Koyama, Hiroki Shirato
PSYCHIATRY RESEARCH-NEUROIMAGING, 212, 3, 208, 215, 2013年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Paradoxical Interventricular Septal Motion as a Major Determinant of Late Gadolinium Enhancement in Ventricular Insertion Points in Pulmonary Hypertension
Takahiro Sato, Ichizo Tsujino, Hiroshi Ohira, Noriko Oyama-Manabe, Yoichi M. Ito, Teruo Noguchi, Asuka Yamada, Daisuke Ikeda, Taku Watanabe, Masaharu Nishimura
PLOS ONE, 8, 6, e66724, 2013年06月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

7対1看護導入がインシデント報告件数に与えた影響について 新人看護職数の増加に着目して
南須原 康行, 佐久嶋 研, 奥原 芳子, 渋谷 かをり, 伊藤 陽一, 石川 誠, 宝金 清博
日本医療マネジメント学会雑誌, 14, 1, 25, 30, (NPO)日本医療マネジメント学会, 2013年05月
日本語

High Reproducibility of Tumor Hypoxia Evaluated by F-18-Fluoromisonidazole PET for Head and Neck Cancer
Shozo Okamoto, Tohru Shiga, Koichi Yasuda, Yoichi M. Ito, Keiichi Magota, Katsuhiko Kasai, Yuji Kuge, Hiroki Shirato, Nagara Tamaki
JOURNAL OF NUCLEAR MEDICINE, 54, 2, 201, 207, 2013年02月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

自主臨床研究における予定症例登録数未達の原因に関する関係者へのインタビュー調査　　　　　　　　　　　　　　　
堀江 奈穂, 佐久嶋 研, 大庭 幸治, 西本 尚樹, 伊藤 陽一, 佐藤 典宏
臨床薬理, 43, Suppl., S265, S265, (一社)日本臨床薬理学会, 2012年10月
日本語

転倒・転落防止及び対応に関する看護師の意識調査　　　　　　　　　　　　　　　
南須原 康行, 佐久嶋 研, 奥原 芳子, 渋谷 かをり, 石川 誠, 伊藤 陽一, 宝金 清博
医療の質・安全学会誌, 7, Suppl., 205, 205, (一社)医療の質・安全学会, 2012年10月
日本語

リストバンド照合による注射製剤における患者間違いインシデントの減少とコスト
佐久嶋 研, 南須原 康行, 奥原 芳子, 渋谷 かをり, 伊藤 陽一, 梅木 玲緒奈, 遠藤 晃, 宝金 清博
日本医療マネジメント学会雑誌, 13, Suppl., 389, 389, (NPO)日本医療マネジメント学会, 2012年09月
日本語

Clinical characteristics and determinants of exacerbation in Japanese patients with COPD: Hokkaido COPD cohort study results
Masaru Suzuki, Hironi Makita, Satoshi Konno, Kaoruko Shimizu, Natsuko Taniguchi, Yoichi M. Ito, Masaharu Nishimura
EUROPEAN RESPIRATORY JOURNAL, 40, 2012年09月
英語

Hyperintense putaminal rim at 1.5 T: prevalence in normal subjects and distinguishing features from multiple system atrophy.
Khin K Tha, Satoshi Terae, Akiko Tsukahara, Hiroyuki Soma, Ryo Morita, Ichiro Yabe, Yoichi M Ito, Hidenao Sasaki, Hiroki Shirato
BMC neurology, 12, 39, 39, 2012年06月18日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Preoperative percutaneous transhepatic portal vein embolization with ethanol injection.
Yusuke Sakuhara, Daisuke Abo, Yu Hasegawa, Tadashi Shimizu, Toshiya Kamiyama, Satoshi Hirano, Daisuke Fukumori, Takeshi Kawamura, Yoichi M Ito, Khin Khin Tha, Hiroki Shirato, Satoshi Terae
AJR. American journal of roentgenology, 198, 4, 914, 22, 2012年04月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Validation Study on the Accuracy of Echocardiographic Measurements of Right Ventricular Systolic Function in Pulmonary Hypertension
Takahiro Sato, Ichizo Tsujino, Hiroshi Ohira, Noriko Oyama-Manabe, Asuka Yamada, Yoichi M. Ito, Chisa Goto, Taku Watanabe, Shinji Sakaue, Masaharu Nishimura
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 25, 3, 280, 286, 2012年03月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Annual Change in Pulmonary Function and Clinical Phenotype in Chronic Obstructive Pulmonary Disease
Masaharu Nishimura, Hironi Makita, Katsura Nagai, Satoshi Konno, Yasuyuki Nasuhara, Masaru Hasegawa, Kaoruko Shimizu, Tomoko Betsuyaku, Yoichi M. Ito, Satoshi Fuke, Takeshi Igarashi, Yasushi Akiyama, Shigeaki Ogura
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 185, 1, 44, 52, 2012年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Prenatal exposure to perfluorinated chemicals and relationship with allergies and infectious diseases in infants
Emiko Okada, Seiko Sasaki, Yasuaki Saijo, Noriaki Washino, Chihiro Miyashita, Sumitaka Kobayashi, Kanae Konishi, Yoichi M. Ito, Rie Ito, Ayako Nakata, Yusuke Iwasaki, Koichi Saito, Hiroyuki Nakazawa, Reiko Kishi
ENVIRONMENTAL RESEARCH, 112, 118, 125, 2012年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Usefulness of portography and contrast-enhanced computed tomography to predict the embolized area in percutaneous transhepatic portal vein embolization with absolute ethanol under temporary balloon occlusion
Yu Hasegawa, Daisuke Abo, Yusuke Sakuhara, Fumi Kato, Tamotsu Kamishimma, Tadashi Shimizu, Yoichi M. Ito, Satoshi Terae, Hiroki Shirato
JAPANESE JOURNAL OF RADIOLOGY, 30, 1, 53, 61, 2012年01月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

In vivo vascularity alterations in repaired rotator cuffs determined by contrast-enhanced ultrasound.
Tadanao Funakoshi, Norimasa Iwasaki, Tamotsu Kamishima, Mutsumi Nishida, Yoichi Ito, Kinya Nishida, Makoto Motomiya, Naoki Suenaga, Akio Minami
The American journal of sports medicine, 39, 12, 2640, 6, 2011年12月, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: The alterations in blood flow after rotator cuff repair remain unclear. Visualization of vascular patterns could clarify basic and clinical investigations. PURPOSE: To assess longitudinal blood flow inside the repaired cuff and the surrounding tissue after rotator cuff repair, using contrast-enhanced ultrasonography. STUDY DESIGN: Descriptive laboratory study. METHODS: Fifteen patients (7 men and 8 women; mean age, 65.0 ± 9.8 years) consented to participate. The patients underwent an ultrasound scan before and 1, 2, and 3 months after surgery. Enhanced ultrasound images were recorded for 1 minute after intravenous injection of contrast reagent. Four regions of interest inside the cuff and 2 regions in the anchor hole and subacromial bursa were superimposed on the obtained images. Calculated areas under the time-intensity curves were expressed in acoustic units (AU). RESULTS: We found area-dependent differences in patterns of alteration and magnitude of blood flow inside the repaired cuff and peritendinous tissues. Vascularity in the articular distal and bursal distal region of the repaired cuff at 1 month postoperatively increased significantly compared with that at the preoperative baseline (76 vs 5 AU, P = .0037; 92 vs 7 AU, P = .043). The vascularity peaked at 1 month after surgery in the bursal area within the cuff but at 2 months in the articular area. The vascularity in the articular proximal region of the repaired cuff was significantly lower than that in the bursal proximal (P = .0046), bursal distal (P = .0183), and articular distal regions (P = .0163) 1 month after surgery. CONCLUSION: Enhancement patterns in intratendinous tissue increased at 1 or 2 months postoperatively and decreased at 3 months. We found area-dependent differences in enhancement patterns inside the repaired cuff and peritendinous tissue. CLINICAL RELEVANCE: Visualization of vascularization using contrast-enhanced ultrasound could help in deciding on an appropriate repair technique or on the form of postoperative rehabilitation after rotator cuff repair.

Identification and further differentiation of subendocardial and transmural myocardial infarction by fast strain-encoded (SENC) magnetic resonance imaging at 3.0 Tesla.
Noriko Oyama-Manabe, Naoki Ishimori, Hiroyuki Sugimori, Marc Van Cauteren, Kohsuke Kudo, Osamu Manabe, Tomoyuki Okuaki, Tamotsu Kamishima, Yoichi M Ito, Hiroyuki Tsutsui, Khin Khin Tha, Satoshi Terae, Hiroki Shirato
European radiology, 21, 11, 2362, 8, 2011年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Early expression of plasma CCL8 closely correlates with survival rate of acute graft-vs.-host disease in mice.
Yamamoto M, Ota A, Hori T, Imai S, Sohma H, Suzuki N, Hatakeyama N, Inazawa N, Ito YM, Kimura H, Tsutsumi H, Kokai Y
Experimental hematology, 39, 11, 1101, 1112, 2011年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Outcome of medium-dose VP-16/CY/TBI superior to CY/TBI as a conditioning regimen for allogeneic stem cell transplantation in adult patients with acute lymphoblastic leukemia
Akio Shigematsu, Junji Tanaka, Ritsuro Suzuki, Yoshiko Atsuta, Takakazu Kawase, Yoichi M. Ito, Takuya Yamashita, Takahiro Fukuda, Keiki Kumano, Koji Iwato, Fumiaki Yoshiba, Heiwa Kanamori, Naoki Kobayashi, Takashi Fukuhara, Yasuo Morishima, Masahiro Imamura
INTERNATIONAL JOURNAL OF HEMATOLOGY, 94, 5, 463, 471, 2011年11月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Model combining hydrodynamics and fractal theory for analysis of in vivo peripheral pulmonary and systemic resistance of shunt cardiac defects
Yoshihiro Nakamura, Shoichi Awa, Hitoshi Kato, Yoichi M. Ito, Akira Kamiya, Takashi Igarashi
JOURNAL OF THEORETICAL BIOLOGY, 287, 64, 73, 2011年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Apolipoprotein E4 Frequencies in a Japanese Population with Alzheimer's Disease and Dementia with Lewy Bodies
Seiju Kobayashi, Masaru Tateno, Tae Woo Park, Kumiko Utsumi, Hitoshi Sohma, Yoichi M. Ito, Yasuo Kokai, Toshikazu Saito
PLOS ONE, 6, 4, e18569, 2011年04月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Single-slice epicardial fat area measurement: do we need to measure the total epicardial fat volume?
Noriko Oyama, Daisuke Goto, Yoichi M. Ito, Naoki Ishimori, Rie Mimura, Tomoo Furumoto, Fumi Kato, Hiroyuki Tsutsui, Nagara Tamaki, Satoshi Terae, Hiroki Shirato
JAPANESE JOURNAL OF RADIOLOGY, 29, 2, 104, 109, 2011年02月, ［査読有り］
英語, 研究論文（学術雑誌）

Prognostic Model for Hepatocellular Carcinoma with Time-Dependent Factors
Kenji Kuwaki, Kazuhiro Nouso, Yoshiyuki Kobayashi, Shinichiro Nakamura, Yoichi M. Ito, Shouta Iwadou, Hiroaki Hagihara, Tetsuya Yasunaka, Junichi Toshimori, Hirokazu Miyatake, Kenji Miyoshi, Hideki Onishi, Yasuhiro Miyake, Bon Shoji, Akinobu Takaki, Hidenori Shiraha, Yoshiaki Iwasaki, Haruhiko Kobashi, Kazuhide Yamamoto
ACTA MEDICA OKAYAMA, 65, 1, 11, 19, 2011年02月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Single-slice epicardial fat area measurement: do we need to measure the total epicardial fat volume?
Noriko Oyama, Daisuke Goto, Yoichi M Ito, Naoki Ishimori, Rie Mimura, Tomoo Furumoto, Fumi Kato, Hiroyuki Tsutsui, Nagara Tamaki, Satoshi Terae, Hiroki Shirato
Japanese journal of radiology, 29, 2, 104, 9, 2011年02月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Detection of patient setup errors with a portal image - DRR registration software application
Kenneth Sutherland, Masayori Ishikawa, Gerard Bengua, Yoichi M. Ito, Yoshiko Miyamoto, Hiroki Shirato
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 12, 3, 2, 15, 2011年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

In vivo visualization of vascular patterns of rotator cuff tears using contrast-enhanced ultrasound.
Tadanao Funakoshi, Norimasa Iwasaki, Tamotsu Kamishima, Mutsumi Nishida, Yoichi Ito, Makoto Kondo, Akio Minami
The American journal of sports medicine, 38, 12, 2464, 71, 2010年12月, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Hypoxia and decreased blood supply have been proposed as risks for tendon rupture. Visualization of the vascularity of intact and torn rotator cuffs would be useful for improving treatments for rotator cuff tear. PURPOSE: To assess vascularity inside a tendon or an adjacent rotator cuff insertion point in patients differing in age and extent of damage to the tendon. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: Ten volunteers (all men) and 15 patients (10 men, 5 women) consented to participate in the study. Contrast agent for enhanced ultrasound was injected intravenously. Enhanced ultrasound images of the torn cuff and the contralateral shoulder were recorded for 1 minute. Four small regions of interest, the articular and bursal sides of the tendon and the medial and lateral sides of the bursa, were studied in all shoulders. RESULTS: There was a significant decrease in blood flow in the intratendinous region in elderly subjects compared with young subjects, but age had no effect on blood flow in bursal tissue. Blood flow in ruptured rotator cuffs did not differ from that in intact rotator cuffs. The intraclass correlation coefficient for intraobserver reproducibility was 0.82 (95% confidence interval: 0.77-0.86). CONCLUSIONS: The findings of this investigation were the hypovascular pattern in intratendinous tissue compared with the subacromial bursa, the age-related decrease in intratendinous vascularity, and the hypovascular pattern in the tendon, regardless of rupture of the tendon. Clarification of vascular patterns inside or around the torn ends of a rotator cuff will assist in the development of successful treatments for torn rotator cuffs.

Investigation of Annexin A5 as a Biomarker for Alzheimer's Disease Using Neuronal Cell Culture and Mouse Model
Mami Yamaguchi, Yasuo Kokai, Shin-ichi Imai, Kumiko Utsumi, Kyoichi Matsumoto, Hirohito Honda, Yuka Mizue, Masako Momma, Tetsu Maeda, Shozo Toyomasu, Yoichi M. Ito, Seijyu Kobayashi, Eri Hashimoto, Toshikazu Saito, Hitoshi Sohma
JOURNAL OF NEUROSCIENCE RESEARCH, 88, 12, 2682, 2692, 2010年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Reduced intensity conditioning regimen with fludarabine, busulfan, and low-dose TBI (Flu-BU2-TBI): Clinical efficacy in high-risk patients
Mutsumi Takahata, Satoshi Hashino, Kohei Okada, Masahiro Onozawa, Kaoru Kahata, Junichi Sugita, Akio Shigematsu, Takeshi Kondo, Satoshi Yamamoto, Tomoyuki Endo, Mitsufumi Nishio, Yoichi M. Ito, Junji Tanaka, Takao Koike, Masahiro Asaka, Masahiro Imamura
AMERICAN JOURNAL OF HEMATOLOGY, 85, 4, 243, 248, 2010年04月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

The sensitivity and specificity of a new formula to distinguish endometrioid type endometrial carcinoma from ovarian endometrial carcinoma
Sadako Nishimura, Yoichi M. Ito, Hiroshi Tsuda, Yoshitaka Ohnishi, Fumio Kataoka, Hiroyuki Nomura, Tatsuyuki Chiyoda, Atsushi Suzuki, Nobuyuki Susumu, Daisuke Aoki, Masayuki Hatae
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 148, 1, 67, 72, 2010年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Minimally Invasive Surgical Treatment for Tuberculous Spondylodiscitis
M. Ito, H. Sudo, K. Abumi, Y. Kotani, M. Takahata, M. Fujita, A. Minami
MINIMALLY INVASIVE NEUROSURGERY, 52, 5-6, 250, 253, 2009年10月, ［査読有り］
英語, 研究論文（学術雑誌）

Managing "healthy" late preterm infants
Akio Ishiguro, Yoshiyuki Namai, Yoichi M. Ito
PEDIATRICS INTERNATIONAL, 51, 5, 720, 725, 2009年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Measurement of (63)Ni produced in Cu samples by the Hiroshima atomic bomb (vol 273, pg 517, 2007)
S. Shibata, K. Takamiya, Y. Ota, N. Nogawa, Y. Ito, T. Shibata, M. Hoshi, S. Endo, H. Hasai, S. Fujita
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 279, 2, 699, 699, 2009年02月
英語, 研究論文（学術雑誌）

N1 component reflects difference of terminal chords in three-chord sequences
Shoko Dekio-Hotta, Tomoyuki Kojima, Shotaro Karino, Tatsuya Yamasoba, Itaru Dekio, Yoichi M. Ito, Hiroyuki Satake, Kimitaka Kaga
NEUROREPORT, 20, 3, 251, 256, 2009年02月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Role of multidrug resistance-associated protein 1 in the pathogenesis of allergic airway inflammation
Masakata Yoshioka, Hironori Sagara, Fumiyuki Takahashi, Norihiro Harada, Kazuto Nishio, Akio Mori, Hiroko Ushio, Kazue Shimizu, Takenori Okada, Mayumi Ota, Yoichi M. Ito, Osamu Nagashima, Ryo Atsuta, Toshihiro Suzuki, Takeshi Fukuda, Yoshinosuke Fukuchi, Kazuhisa Takahashi
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 296, 1, L30, L36, 2009年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Factors Associated with Variation in Utility Scores among Patients with Prostate Cancer
Fumitaka Shimizu, Katsuki Fujino, Yoichi M. Ito, Takashi Fukuda, Yoshio Kawachi, Shigeru Minowada, Makoto Fujime, Yasuo Ohashi
VALUE IN HEALTH, 11, 7, 1190, 1193, 2008年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

A neural network approach to simple prediction of soil nitrification potential: A case study in Japanese temperate forests
Eriko Ito, Kenji Ono, Yoichi M. Ito, Makoto Araki
ECOLOGICAL MODELLING, 219, 1-2, 200, 211, 2008年11月
英語, 研究論文（学術雑誌）

Prognostic factors and treatment effects for hepatocellular carcinoma in Child C cirrhosis
K. Nouso, Y. M. Ito, K. Kuwaki, Y. Kobayashi, S. Nakamura, Y. Ohashi, K. Yamamoto
British Journal of Cancer, 98, 7, 1161, 1165, 2008年04月08日, ［査読有り］
英語, 研究論文（学術雑誌）

Sensitivity and specificity of des-gamma-carboxy prothrombin for diagnosis of patients with hepatocellular carcinomas varies according to tumor size
Shinichiro Nakamura, Kazuhiro Nouso, Kohsaku Sakaguchi, Yoichi M. Ito, Yasuo Ohashi, Yoshiyuki Kobayashi, Nobuyuki Toshikuni, Hironori Tanaka, Yasuhiro Miyake, Eiji Matsumoto, Yasushi Shiratori
AMERICAN JOURNAL OF GASTROENTEROLOGY, 101, 9, 2038, 2043, 2006年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Prevalence of Epstein-Barr virus in Japan: Trends and future prediction
K Takeuchi, K Tanaka-Taya, Y Kazuyama, YM Ito, S Hashimoto, M Fukayama, S Mori
PATHOLOGY INTERNATIONAL, 56, 3, 112, 116, 2006年03月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses
H Tsuda, YM Ito, Y Ohashi, KK Wong, Y Hashiguchi, WR Welch, RS Berkowitz, MJ Birrer, SC Mok
CLINICAL CANCER RESEARCH, 11, 19, 6880, 6888, 2005年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Burkholderia pickettii spondylitis
H Sudo, Y Hisada, M Ito, H Kotaki, A Minami
SPINAL CORD, 43, 8, 499, 502, 2005年08月, ［査読有り］
英語, 研究論文（学術雑誌）

Alcohol consumption and colorectal cancer risk: Findings from the JACC study
K Wakai, M Kojima, K Tamakoshi, Y Watanabe, N Hayakawa, K Suzuki, S Hashimoto, M Kawado, S Tokudome, S Suzuki, K Ozasa, H Toyoshima, Y Ito, A Tamakoshi
JOURNAL OF EPIDEMIOLOGY, 15, S173, S179, 2005年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Medical history of circulatory diseases and colorectal cancer death in the JACC study
Y Watanabe, K Ozasa, Y Ito, K Suzuki, M Kojima, S Suzuki, S Tokudome, K Tamakoshi, H Toyoshima, M Kawado, S Hashimoto, N Hayakawa, K Wakai, A Tamakoshi
JOURNAL OF EPIDEMIOLOGY, 15, S168, S172, 2005年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Glucose intolerance and colorectal cancer risk in a nested case-control study among Japanese people
K Ozasa, Y Ito, K Suzuki, Y Watanabe, M Kojima, S Suzuki, S Tokudome, K Tamakoshi, H Toyoshima, M Kawado, S Hashimoto, N Hayakawa, K Wakai, A Tamakoshi
JOURNAL OF EPIDEMIOLOGY, 15, S180, S184, 2005年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Colorectal cancer and serum C-reactive protein levels: a case-control study nested in the JACC study
Y Ito, K Suzuki, K Tamakoshi, K Wakai, M Kojima, K Ozasa, Y Watanabe, M Kawado, S Hashimoto, S Suzuki, S Tokudome, H Toyoshima, N Hayakawa, K Kato, M Watanabe, Y Ohta, M Maruta, A Tamakoshi
JOURNAL OF EPIDEMIOLOGY, 15, S185, S189, 2005年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Stability of frozen serum levels of insulin-like growth factor-I, insulin-like growth factor-II, insulin-like growth factor binding protein-3, transforming growth factor beta, soluble fas, and superoxide dismutase activity for the JACC study
Y Ito, K Nakachi, K Imai, S Hashimoto, Y Watanabe, Y Inaba, A Tamakoshi, T Yoshimura
JOURNAL OF EPIDEMIOLOGY, 15, S67, S73, 2005年03月, ［査読有り］
英語, 研究論文（学術雑誌）

Serum levels of polyunsaturated fatty acids and risk of colorectal cancer: A prospective study
M Kojima, K Wakai, S Tokudome, K Suzuki, K Tamakoshi, Y Watanabe, M Kawado, S Hashimoto, N Hayakawa, K Ozasa, H Toyoshima, S Suzuki, Y Ito, A Tamakoshi
AMERICAN JOURNAL OF EPIDEMIOLOGY, 161, 5, 462, 471, 2005年03月, ［査読有り］
英語, 研究論文（学術雑誌）

Quantitative assessment of regional myocardial flow reserve using Tc-99m-Sestamibi imaging - Comparison with results of O-15 water PET
T Tsukamoto, Y Ito, K Noriyasu, K Morita, C Katoh, H Okamoto, N Tamaki
CIRCULATION JOURNAL, 69, 2, 188, 193, 2005年02月, ［査読有り］
英語, 研究論文（学術雑誌）

Perceived psychologic stress and colorectal cancer mortality: Findings from the Japan collaborative cohort study
M Kojima, K Wakai, S Tokudome, K Tamakoshi, H Toyoshima, Y Watanabe, N Hayakawa, K Suzuki, S Hashimoto, M Kawado, S Suzuki, Y Ito, A Tamakoshi
PSYCHOSOMATIC MEDICINE, 67, 1, 72, 77, 2005年01月, ［査読有り］
英語, 研究論文（学術雑誌）

Leptin is associated with an increased female colorectal cancer risk: A nested case-control study in Japan
K Tamakoshi, H Toyoshima, K Wakai, M Kojima, K Suzuki, Y Watanabe, N Hayakawa, H Yatsuya, T Kondo, S Tokudome, S Hashimoto, S Suzuki, M Kawado, K Ozasa, Y Ito, A Tamakoshi
ONCOLOGY, 68, 4-6, 454, 461, 2005年, ［査読有り］
英語, 研究論文（学術雑誌）

Serum carotenoids, retinol, and tocopherols, and colorectal cancer risk in a Japanese cohort: Effect modification by sex for carotenoids
K Wakai, K Suzuki, Y Ito, M Kojima, K Tamakoshi, Y Watanabe, H Toyoshima, N Hayakawa, S Hashimoto, S Tokudome, S Suzuki, M Kawado, K Ozasa, A Tamakoshi
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 51, 1, 13, 24, 2005年, ［査読有り］
英語, 研究論文（学術雑誌）

Identification of DNA copy number changes in microdissected serous ovarian cancer tissue using a cDNA microarray platform
H Tsuda, MJ Birrer, YM Ito, Y Ohashi, M Lin, C Lee, WH Wong, PH Rao, CC Lau, RS Berkowitz, KK Wong, SC Mok
CANCER GENETICS AND CYTOGENETICS, 155, 2, 97, 107, 2004年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Regulation of mineral-to-matrix ratio of lumbar trabecular bone in ovariectomized rats treated with risedronate in combination with or without vitamin K-2
H Otomo, A Sakai, S Ikeda, S Tanaka, M Ito, RJ Phipps, T Nakamura
JOURNAL OF BONE AND MINERAL METABOLISM, 22, 5, 404, 414, 2004年09月, ［査読有り］
英語, 研究論文（学術雑誌）

Validity and clinical applicability of the Japanese version of amyotrophic lateral sclerosis: Assessment questionnaire 40 (ALSAQ-40)
Takuhiro Yamaguchi, Sadayoshi Ohbu, Mari Saito, Yoichi Ito, Fumio Moriwaka, Kunio Tashiro, Yasuo Ohashi, Shun-Ichi Fukuhara
Brain and Nerve, 56, 6, 483, 494, 2004年06月, ［査読有り］
日本語, 研究論文（学術雑誌）

A prospective study of body size and colon cancer mortality in Japan: The JACC Study
K Tamakoshi, K Wakai, M Kojima, Y Watanabe, N Hayakawa, H Toyoshima, H Yatsuya, T Kondo, S Tokudome, S Hashimoto, K Suzuki, Y Ito, A Tamakoshi
INTERNATIONAL JOURNAL OF OBESITY, 28, 4, 551, 558, 2004年04月, ［査読有り］
英語, 研究論文（学術雑誌）

Bowel movement frequency and risk of colorectal cancer in a large cohort study of Japanese men and women
M Kojima, K Wakai, S Tokudome, K Tamakoshi, H Toyoshima, Y Watanabe, N Hayakawa, K Suzuki, S Hashimoto, Y Ito, A Tamakoshi
BRITISH JOURNAL OF CANCER, 90, 7, 1397, 1401, 2004年04月, ［査読有り］
英語, 研究論文（学術雑誌）

UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma in Japanese patients with hepatitis C virus infection
Y Wang, N Kato, Y Hoshida, M Otsuka, H Taniguchi, M Moriyama, S Shiina, T Kawabe, YM Ito, M Omata
CLINICAL CANCER RESEARCH, 10, 7, 2441, 2446, 2004年04月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

A prospective study on the possible association between having children and colon cancer risk: Findings from the JACC Study
K Tamakoshi, K Wakai, M Kojima, Y Watanabe, N Hayakawa, H Toyoshima, H Yatsuya, T Kondo, S Tokudome, S Hashimoto, K Suzuki, Y Ito, A Tamakoshi
CANCER SCIENCE, 95, 3, 243, 247, 2004年03月, ［査読有り］
英語, 研究論文（学術雑誌）

Diet and colorectal cancer mortality: Results from the Japan Collaborative Cohort Study
M Kojima, K Wakai, K Tamakoshi, S Tokudome, H Toyoshima, Y Watanabe, N Hayakawa, K Suzuki, S Hashimoto, Y Ito, A Tamakoshi
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 50, 1, 23, 32, 2004年, ［査読有り］
英語, 研究論文（学術雑誌）

Effect of preoperative transbronchial biopsy on prognosis of non-small cell lung cancer
Jun Nakajima, Shinichi Takamoto, Jun Matsumoto, Eriho Takeuchi, Yoichi M. Ito
Asian Cardiovascular and Thoracic Annals, 12, 4, 330, 335, Asia Publishing Exchange Pte Ltd, 2004年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Smoking and colorectal cancer in a non-western population: a prospective Cohort Study in Japan
K Wakai, N Hayakawa, M Kojima, K Tamakoshi, Y Watanabe, K Suzuki, S Hashimoto, S Tokudome, H Toyoshima, Y Ito, A Tamakoshi
JOURNAL OF EPIDEMIOLOGY, 13, 6, 323, 332, 2003年11月, ［査読有り］
英語, 研究論文（学術雑誌）

In vitro biomechanical effects of reconstruction on adjacent motion segment: comparison of aligned/kyphotic posterolateral fusion with aligned posterior lumbar interbody fusion/posterolateral fusion
H Sudo, Oda, I, K Abumi, M Ito, Y Kotani, Y Hojo, A Minami
JOURNAL OF NEUROSURGERY, 99, 2, 221, 228, 2003年09月, ［査読有り］
英語, 研究論文（学術雑誌）

A moving middle finger
H Sudo, M Ito, A Minami
LANCET, 361, 9376, 2202, 2202, 2003年06月, ［査読有り］
英語

Reduction of coronary flow reserve in areas with and without ischemia on stress perfusion imaging in patients with coronary artery disease: A study using oxygen 15-labeled water PET
K Yoshinaga, C Katoh, K Noriyasu, Y Iwado, H Furuyama, Y Ito, Y Kuge, T Kohya, A Kitabatake, N Tamaki
JOURNAL OF NUCLEAR CARDIOLOGY, 10, 3, 275, 283, 2003年05月, ［査読有り］
英語, 研究論文（学術雑誌）

[Validation of the Japanese version of the Parkinson's Disease Questionnaire].
Kohmoto J, Ohbu S, Nagaoka M, Suzukamo Y, Kihira T, Mizuno Y, Ito YM, Hith M, Yamaguchi T, Ohashi Y, Fukuhara S, Kondo T
Rinsho shinkeigaku = Clinical neurology, 43, 3, 71, 76, 2003年03月, ［査読有り］, ［国内誌］
日本語, 研究論文（学術雑誌）, UNLABELLED: The PDQ-39 (Parkinson's Disease Questionnaire-39) is a specific quality-of-life (QOL) scale for patients with Parkinson's disease (PD). It evaluates the dysfunction of daily living and quality of life. We developed the Japanese-translated version of PDQ-39 and examined the validity of the PDQ-39 in Japanese PD patients. SUBJECTS: A total of 156 patients with PD were studied (age 35-86 years, Hoehn-Yahr stage 1 to 4). None of the patients had dementia. METHODS: Semi-structured interviews were conducted by one trained interviewer. The PDQ-39, SF-36 (36-item short form of the Medical Outcome Study questionnaire), EQ5D (Euro Qol), and NAS-J (Nottingham Adjustment Scale Japanese version) were used for evaluation. The attending physician of each patient rated the patient's condition by using the UPDRS (Unified Parkinson's Disease Rating Scale). RESULTS: Exploratory factor analysis, Cronbach alpha, and construct validity were fair, and there were significant correlations between the results of the PDQ-39 and the corresponding parts of the UPDRS and SF-36, and the Hoehn-Yahr stage, respectively. CONCLUSION: The Japanese version of the PDQ-39 is valuable for evaluating the QOL of Japanese patients with PD. Results of comparison of PDQ-39 with other scales of the QOL such as NAS-J suggest the possibility that acceptance of the disease and feelings of self-achievement improve the QOL of patients with Parkinson's disease.

Altered myocardial flow reserve and endothelial function late after Kawasaki disease
H Furuyama, Y Odagawa, C Katoh, Y Iwado, Y Ito, K Noriyasu, M Mabuchi, K Yoshinaga, Y Kuge, K Kobayashi, N Tamaki
JOURNAL OF PEDIATRICS, 142, 2, 149, 154, 2003年02月, ［査読有り］
英語, 研究論文（学術雑誌）

Spinal cord compression by multistrand cables after solid posterior atlantoaxial fusion - Report of three cases
H Sudo, K Abumi, M Ito, Y Kotani, A Minami
JOURNAL OF NEUROSURGERY, 97, 3, 359, 361, 2002年10月, ［査読有り］
英語, 研究論文（学術雑誌）

QOL質問票における項目反応理論に対するパラメータ推定
伊藤 陽一, 大橋 靖雄
計量生物学, 23, 1, 3, 26, The Biometric Society of Japan, 2002年09月30日
日本語, Item Response Theory (IRT) is a promising concept for constructing and calibrating health related quality of life questionnaires. The most popular IRT model is the two-parameter logistic model, and its parameters are often estimated by the Marginal Maximum Likelihood method (MML). However, performance of estimation by MML is poor in a small sample, such as severe or rare disease patients. The purpose of this study was to propose a Bayesian method for improving the performance and to compare the precision and accuracy of estimates by different methods with a simulation. In the simulation, item responses were generated according to the two-parameter logistic model. The estimates obtained using a MML Program (MULTILOG) and a Bayesian program written in this study were compared with respect to the precision and accuracy. The proposed method could improve the performance about difficulty parameters using more than 100 individuals and 10 items. Though that about discrimination parameters was still poor. For example, 137 patients received the Parkinson's disease specific questionnaire (PDQ-39) and a generic one (SF-36); and we calibrated items of physical functioning in these questionnaire simultaneously. It was shown that half of the PDQ-39 items could measure the ability of patients at a little bit high level of physical functioning more efficiently than SF-36.

Quantitative analysis of regional wall motion and thickening by quantitative gated SPECT comparison with visual analysis
M Konno, K Morita, Adach, I, Y Ito, T Kohya, A Kitabatake, E Tsukamoto, N Tamaki
CLINICAL NUCLEAR MEDICINE, 26, 3, 202, 207, 2001年03月, ［査読有り］
英語, 研究論文（学術雑誌）

Preparation of highly unsaturated fatty acid-containing phosphatidylcholine by transesterification with phospholipase A(2)
M Hosokawa, M Ito, K Takahashi
BIOTECHNOLOGY TECHNIQUES, 12, 8, 583, 586, 1998年08月, ［査読有り］
英語, 研究論文（学術雑誌）

cT1腎癌に対する開腹腎部分切除術と鏡視下腎部分切除術後のSF-36を用いたQOLの比較　　　　　　　　　　　　　　　
大澤 崇宏, 安部 崇重, 菊地 央, 松本 隆児, 宮島 直人, 土屋 邦彦, 丸山 覚, 伊藤 陽一, 村井 祥代, 篠原 信雄, 泌尿器外科, 32, 7, 985, 986, 2019年07月
医学図書出版(株), 日本語

NORTH/HGCSG1003 Stage III結腸癌に対する術後補助化学療法FOLFOXの第II相研究 腫瘍内科医と外科医の比較　　　　　　　　　　　　　　　
村中 徹人, 小松 嘉人, 結城 敏志, 川本 泰之, 高橋 典彦, 七戸 俊明, 久須美 貴哉, 中村 文隆, 大森 一吉, 伊藤 陽一, 武冨 紹信, 平野 聡, 坂本 直哉, 日本大腸肛門病学会雑誌, 72, 1, 48, 48, 2019年01月
(一社)日本大腸肛門病学会, 日本語

日本における臨床研究の現状と,観察データに基づく臨床研究 リアルワールドデータの利用　　　　　　　　　　　　　　　
伊藤 陽一, 統計数理研究所データ科学研究系, 公衆衛生, 82, 12, 907, 11, 2018年12月
記事・総説・解説・論説等（学術雑誌）

Bladder Cancer Index(BCI)日本語版の開発におけるPilot Study　　　　　　　　　　　　　　　
大澤 崇宏, ウェイ・ジョン, 伊藤 陽一, 成田 学, 賀古 勇輝, 宮田 遙, 菊地 央, 松本 隆児, 宮島 直人, 丸山 覚, 安部 崇重, 村井 祥代, 篠原 信雄, 日本泌尿器科学会総会, 106回, PP1, 201, 2018年04月
(一社)日本泌尿器科学会総会事務局, 日本語

放射線治療における数値指標の医学物理的利用
清水伸一, 小橋啓司, 伊藤陽一, PRAYONGRAT Anussara, 加藤徳雄, 安田耕一, 出倉康裕, 木元拓也, 白土博樹, 日本放射線腫瘍学会高精度放射線外部照射部会学術大会プログラム・抄録集, 31st (CD-ROM), 39, 2018年
日本語

北海道における多系統萎縮症レジストリ研究:HoRC-MSA2014-2017　　　　　　　　　　　　　　　
松島 理明, 佐久嶋 研, 矢部 一郎, 金谷 泰宏, 伊藤 陽一, 松岡 健, 片山 隆行, 上杉 春雄, 佐光 一也, 武井 麻子, 下濱 俊, 佐藤 典宏, 菊地 誠志, 佐々木 秀直, 臨床神経学, 57, 12, 813, 813, 2017年12月
(一社)日本神経学会, 日本語

pStage III結腸癌に対するFOLFOXの第II相試験[NORTH/HGCSG1003]原発部位による解析　　　　　　　　　　　　　　　
篠原 敏樹, 結城 敏志, 川本 泰之, 中積 宏之, 高橋 典彦, 七戸 俊明, 久須美 貴哉, 中村 文隆, 小林 良充, 岩永 一郎, 伊藤 陽一, 坂本 直哉, 武冨 紹信, 平野 聡, 小松 嘉人, 日本癌治療学会学術集会抄録集, 55回, O29, 2, 2017年10月
(一社)日本癌治療学会, 日本語

North Japan multicenter phase II study of FOLFOX as adjuvant chemotherapy for stage III colon cancer (NORTH/HGCSG1003): Analysis of tumor location
A. Ishiguro, S. Yuki, Y. Kawamoto, H. Nakatsumi, N. Takahashi, T. Shichinohe, T. Kusumi, I. Iwanaga, T. Miyagishima, K. Hatanaka, K. Oomori, M. Nakamura, N. Senmaru, K. Iwai, M. Koike, N. Sakamoto, A. Taketomi, S. Hirano, Y. M. Ito, Y. Komatsu, ANNALS OF ONCOLOGY, 28, 2017年09月
英語, 研究発表ペーパー・要旨（国際会議）

Stage III結腸癌の術後補助化学療法としてのFOLFOX療法の第II相臨床試験 NORTH/HGCSG1003　　　　　　　　　　　　　　　
仙丸 直人, 結城 敏志, 七戸 俊明, 高橋 典彦, 川本 泰之, 中積 宏之, 久須美 貴哉, 中村 文隆, 小林 良充, 岩永 一郎, 畑中 一映, 三澤 一仁, 岩井 和浩, 小池 雅彦, 伊藤 陽一, 坂本 直哉, 平野 聡, 武冨 紹信, 坂田 優, 小松 嘉人, 日本消化器病学会雑誌, 114, 臨増大会, A842, A842, 2017年09月
(一財)日本消化器病学会, 日本語

腹腔鏡下鼠径ヘルニア修復術の新しいトレーニングシステムの開発及び教育効果の検討 多施設無作為比較試験　　　　　　　　　　　　　　　
Poudel Saseem, 倉島 庸, 田中 公貴, 川瀬 寛, 村上 康洋, 川原田 陽, 伊藤 陽一, 七戸 俊明, 平野 聡, 日本外科学会定期学術集会抄録集, 117回, SF, 51, 2017年04月
(一社)日本外科学会, 日本語

MOLECULAR DETERMINANTS OF FUNCTIONAL CHANGES AND FIBROSIS DETERMINED BY NOVEL AUTOMATED OSCILLOMETRIC APPROACH TO MEASURE BRACHIAL ARTERY VASCULAR VOLUME ELASTIC MODULUS IN CHRONIC KIDNEY DISEASE
Keiichiro Yoshinaga, Yoichi Ito, Satoshi Fujii, Saori Nishio, Noriki Ochi, Katoh Chietsugu, Mamiko Inoue, Mutsumi Nishida, Osamu Manabe, Nagara Tamaki, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 69, 11, 2086, 2086, 2017年03月
英語, 研究発表ペーパー・要旨（国際会議）

North Japan multicenter phase II study of oxaliplatin-containing regimen as adjuvant chemotherapy for stage III colon cancer (NORTH/HGCSG1003).
Toshiaki Shichinohe, Satoshi Yuki, Norihiko Takahashi, Hiroshi Nakatsumi, Yasuyuki Kawamoto, Takaya Kusumi, Atsushi Ishiguro, Susumu Sogabe, Ichiro Iwanaga, Kazuteru Hatanaka, Kazuyoshi Oomori, Michio Nakamura, Naoto Senmaru, Kazuhiro Iwai, Masahiko Koike, Naoya Sakamoto, Akinobu Taketomi, Satoshi Hirano, Yoichi M. Ito, Yoshito Komatsu, JOURNAL OF CLINICAL ONCOLOGY, 35, 4, 2017年02月
英語, 研究発表ペーパー・要旨（国際会議）

左室収縮が保持された心不全における¹¹C-HED PETを用いた局所心筋交感神経分布の検討
相川忠夫, 納谷昌直, 小原雅彦, 真鍋徳子, 真鍋治, 小梁川和宏, 孫田恵一, 伊藤陽一, 志賀哲, 加藤千恵次, 玉木長良, 核医学(Web), 54, Supplement, 2017年

北海道における多系統萎縮症レジストリ研究 HoRC-MSA　　　　　　　　　　　　　　　
松島 理明, 佐久嶋 研, 矢部 一郎, 伊藤 陽一, 片山 隆行, 佐光 一也, 森 満, 下濱 俊, 佐藤 典宏, 菊地 誠志, 佐々木 秀直, 北海道保健福祉部健康安全局地域保健課感染症, 特定疾患グループ, 臨床神経学, 56, Suppl., S484, S484, 2016年12月
(一社)日本神経学会, 日本語

脊髄小脳変性症における歩行解析(第二報)　　　　　　　　　　　　　　　
白井 慎一, 矢部 一郎, 松島 理明, 伊藤 陽一, 米山 満, 佐々木 秀直, 臨床神経学, 56, Suppl., S487, S487, 2016年12月
(一社)日本神経学会, 日本語

北海道における多系統萎縮症のレジストリ研究 HoRC-MSA 2015-2016　　　　　　　　　　　　　　　
松島 理明, 佐久嶋 研, 矢部 一郎, 金谷 泰宏, 伊藤 陽一, 片山 隆行, 佐光 一也, 武井 麻子, 森 満, 下濱 俊, 佐藤 典宏, 菊地 誠志, 佐々木 秀直, 北海道保健福祉部健康安全局地域保健課感染症, 特定疾患グループ, 臨床神経学, 56, 11, 802, 802, 2016年11月
(一社)日本神経学会, 日本語

女性医療人の労働生活の質評価尺度の開発と検証
武冨 貴久子, 伊藤 陽一, 徳永 えり子, 平野 裕子, 藤野 ユリ子, 樗木 晶子, 大滝 純司, 医学教育, 47, Suppl., 190, 190, 2016年07月
(一社)日本医学教育学会, 日本語

An Evaluation Method of Lifetime Attributable Risk for Comparing Between Proton Beam Therapy and Intensity Modulated X-Ray Therapy for Pediatric Cancer Patients by Averaging Four Dose-Response Models for Carcinoma Induction
M. Tamura, Y. Ito, H. Sakurai, M. Mizumoto, S. Kamizawa, S. Murayama, H. Yamashita, S. Takao, R. Suzuki, H. Shirato, MEDICAL PHYSICS, 43, 6, 3508, 3508, 2016年06月
英語, 研究発表ペーパー・要旨（国際会議）

北海道における多系統萎縮症のレジストリ研究:HoRC-MSA 2015-2016
松島理明, 佐久嶋研, 矢部一郎, 金谷泰宏, 伊藤陽一, 片山隆行, 佐光一也, 武井麻子, 森満, 下濱俊, 佐藤典宏, 菊地誠志, 佐々木秀直, 臨床神経学(Web), 56, 11, 2016年

Ten Years' Mortality Data Of Patients With Chronic Obstructive Pulmonary Disease From The Hokkaido COPD Cohort Study
H. Makita, M. Suzuki, S. Konno, K. Shimizu, Y. M. Ito, M. Nishimura, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 193, 2016年
英語, 研究発表ペーパー・要旨（国際会議）

Safety analysis of FOLFOX as adjuvant chemotherapy for stage III colon cancer in phase II study (NORTH/HGCSG1003) - an analysis of surgeons vs oncologists
A. Ishiguro, S. Yuki, Y. Kawamoto, F. Nakamura, N. Takahashi, T. Shichinohe, T. Kusumi, S. Sogabe, K. Hatanaka, K. Misawa, M. Nenohi, H. Hayashi, H. Fukushima, M. Takahashi, T. Amano, Y. M. Ito, N. Sakamoto, A. Taketomi, S. Hirano, Y. Komatsu, ANNALS OF ONCOLOGY, 26, 50, 50, 2015年12月
英語, 研究発表ペーパー・要旨（国際会議）

北海道における多系統萎縮症のレジストリ研究:HoRC‐MSA step 2
松島理明, 佐久嶋研, 矢部一郎, 伊藤陽一, 片山隆行, 佐光一也, 森満, 下濱俊, 佐藤典宏, 菊地誠志, 佐々木秀直, 臨床神経学(Web), 55, 12, 945(J‐STAGE), 945, 2015年12月
(一社)日本神経学会, 日本語

北海道における多系統萎縮症のレジストリ研究 HoRC-MSA step2　　　　　　　　　　　　　　　
松島 理明, 佐久嶋 研, 矢部 一郎, 伊藤 陽一, 片山 隆行, 佐光 一也, 森 満, 下濱 俊, 佐藤 典宏, 菊地 誠志, 佐々木 秀直, 臨床神経学, 55, 12, 945, 945, 2015年12月
(一社)日本神経学会, 日本語

Particle Therapy Using Protons or Carbon Ions for Cancer Patients With Cardiac Implantable Electronic Devices (CIEDs): A Retrospective Japan Radiological Society Multi-institutional Study
T. Hashimoto, Y. Demizu, T. Isobe, H. Numajiri, S. Fukuda, M. Wakatsuki, H. Yamashita, S. Murayama, S. Takamatsu, H. Katoh, K. Murata, R. Kohno, T. Arimura, T. Matsuura, Y. M. Ito, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93, 3, E563, E564, 2015年11月
英語, 研究発表ペーパー・要旨（国際会議）

NTCP Modeling Analysis of Acute Hematologic Toxicity in Whole-Pelvic Radiation Therapy for Gynecologic Malignancies: A Dosimetric Comparison of IMRT and Spot-Scanning Proton Therapy
T. Yoshimura, R. Kinoshita, S. Onodera, C. Toramatsu, R. Suzuki, Y. M. Ito, S. Takao, T. Matsuura, Y. Matsuzaki, S. Shimizu, K. Umegaki, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93, 3, E254, E254, 2015年11月
英語, 研究発表ペーパー・要旨（国際会議）

Altered Vascular Elasticity Reflected Vascular Endothelial Dysfunction and Elevated Galectin-3 Using Novel Brachial Artery Vascular Volume Elastic Modulus With Automated Oscillometric Approach
Keiichiro Yoshinaga, Yuuki Tomiyama, Satoshi Fujii, Saori Nishio, Noriki Ochi, Chietsugu Katoh, Mamiko Inoue, Mutumi Nishida, Keisuke Takeuchi, Yoichi M. Ito, Nagara Tamaki, CIRCULATION, 132, 2015年11月
英語, 研究発表ペーパー・要旨（国際会議）

The Voxel-based Analysis of FMISO-PET Image in Patients With Local Recurrence of Nasopharyngeal Carcinoma
Y. Nishikawa, K. Yasuda, S. Okamoto, Y. M. Ito, T. Mori, R. Onimaru, T. Shiga, K. Tsuchiya, S. Watanabe, W. Takeuchi, N. Katoh, Y. Kuge, N. Tamaki, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93, 3, E337, E337, 2015年11月
英語, 研究発表ペーパー・要旨（国際会議）

HPV vaccination crisis in Japan (vol 385, pg 2571, 2015)
S. J. B. Hanley, E. Yoshioka, Y. Ito, R. Kishi, LANCET, 386, 9990, 248, 248, 2015年07月
英語, その他

Safety analysis of FOLFOX as adjuvant chemotherapy for stage III colon cancer in phase II study (NORTH/HGCSG1003) - an analysis of surgeons vs oncologists
I. Iwanaga, S. Yuki, H. Fukushima, N. Takahashi, T. Shichinohe, T. Kusumi, F. Nakamura, S. Sogabe, K. Hatanaka, K. Oomori, K. Misawa, N. Senmaru, K. Iwai, T. Shinohara, M. Koike, K. Miyashita, T. Amano, Y. M. Ito, N. Sakamoto, A. Taketomi, S. Hirano, Y. Komatsu, ANNALS OF ONCOLOGY, 26, 2015年06月
英語, 研究発表ペーパー・要旨（国際会議）

Safety analysis of FOLFOX as adjuvant chemotherapy for stage III colon cancer in phase II study (NORTH/HGCSG1003): Detailed analysis of peripheral sensory neuropathy.
Susumu Sogabe, Satoshi Yuki, Hiraku Fukushima, Norihiko Takahashi, Toshiaki Shichinohe, Takaya Kusumi, Fumitaka Nakamura, Ichiro Iwanaga, Kazuteru Hatanaka, Kencho Miyashita, Jun Konno, Kazuhito Uemura, Masaaki Nenohi, Masaya Kina, Naoya Sakamoto, Akinobu Taketomi, Satoshi Hirano, Toraji Amano, Yoichi M. Ito, Yoshito Komatsu, JOURNAL OF CLINICAL ONCOLOGY, 33, 3, 2015年01月
英語, 研究発表ペーパー・要旨（国際会議）

DIFFERENTIAL CHANGES OF COMPONENTS IN QUALITY OF LIFE OVER 5 YEARS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS
H. Makita, K. Nagai, M. Suzuki, K. Shimizu, S. Konno, Y. M. Ito, M. Nishimura, RESPIROLOGY, 19, 126, 126, 2014年11月
英語, 研究発表ペーパー・要旨（国際会議）

Novel Simple and Accurate Quantitative Endothelial Function Measurements Using Brachial Artery Vascular Volume Elastic Modulus With Automated Oscillometric Approach
Keiichiro Yoshinaga, Yuuki Tomiyama, Satoshi Fujii, Saori Nishio, Naoko Matsuoka, Noriki Ochi, Chietsugu Katoh, Mamiko Inoue, Mutumi Nishida, Yoichi M. Ito, Hideo Nishibayashi, Nagara Tamaki, CIRCULATION, 130, 2014年11月
英語, 研究発表ペーパー・要旨（国際会議）

Impaired coronary and peripheral artery vascular function in smokers - Comprehensive evaluation using Oxygen-15 labeled water PET and brachial artery ultrasound
Noriki Ochi, Keiichiro Yoshinaga, Yuuki Tomiyama, Chietsugu Katoh, Mamiko Inoue, Mutsumi Nishida, Eriko Suzuki, Osamu Manabe, Yoichi Ito, Nagara Tamaki, JOURNAL OF NUCLEAR MEDICINE, 55, 2014年05月
英語, 研究発表ペーパー・要旨（国際会議）

Predictive value of FDG PET at initial radioiodine therapy for survival of high-risk patients with differentiated thyroid cancer
Florian Gaertner, Shozo Okamoto, Tohru Shiga, Yoichi Ito, Yuko Uchiyama, Osamu Manabe, Naoya Hattori, Nagara Tamaki, JOURNAL OF NUCLEAR MEDICINE, 55, 2014年05月
英語, 研究発表ペーパー・要旨（国際会議）

Impaired Vascular Elastic Mechanics Predict Endothelial Dysfunction in Chronic Kidney Disease
YOSHINAGA Keiichiro, TOMIYAMA Yuuki, NISHIO Saori, MATSUOKA Naoko, OCHI Noriki, KATOH Chietsugu, INOUE Mamiko, ITO Yoichi, NISHIBAYASHI Hideo, FUJII Satoshi, TAMAKI Nagara, Circ J, 78, Supplement 1(CD-ROM), ROMBUNNO.PE-375, 2014年02月20日
英語

Impaired Peripheral Artery and Coronary Endothelial Function in Healthy Young Smokers Using Brachial Artery Ultrasound and Oxygen-15 Labeled Water PET
OCHI Noriki, YOSHINAGA Keiichiro, ITO Yoichi, TOMIYAMA Yuuki, KATOH Chietsugu, INOUE Mamiko, NISHIDA Mutsumi, SUZUKI Eriko, MANABE Osamu, TAMAKI Nagara, Circ J, 78, Supplement 1(CD-ROM), ROMBUNNO.OJ-039, 2014年02月20日
英語

SIMPLE PREDICTION OF RIGHT VENTRICULAR EJECTION FRACTION USING TRICUSPID ANNULAR PLANE SYSTOLIC EXCURSION IN PULMONARY HYPERTENSION
Takahiro Sato, Ichizo Tsujino, Noriko Oyama-Manabe, Hiroshi Ohira, Yoichi. M. Ito, Hiroyuki Sugimori, Asuka Yamada, Chisa Takashina, Taku Watanabe, Masaharu Nishimura, RESPIROLOGY, 18, 20, 20, 2013年11月
英語, 研究発表ペーパー・要旨（国際会議）

Right Atrial Volume and Reservoir Function are Novel Predictors of Clinical Worsening in Pulmonary Hypertension
Takahiro Sato, Ichizo Tsujino, Hiroshi Ohira, Noriko Oyama-Manabe, Yoichi M. Ito, Masaharu Nishimura, CIRCULATION, 128, 22, 2013年11月
英語, 研究発表ペーパー・要旨（国際会議）

THE EFFECTS OF AN ARG16GLY ADRB2 POLYMORPHISM ON RESPONSES TO SALMETEROL OR MONTELUKAST IN JAPANESE PATIENTS WITH MILD PERSISTENT ASTHMA
Satoshi Konno, Nobuyuki Hizawa, Hironi Makita, Kaoruko Shimizu, Tohru Sakamoto, Fumio Kokubu, Takefumi Saito, Takeo Endo, Hiroki Ninomiya, Hiroaki Iijima, Norihiro Kaneko, Yoichi Ito, Masaharu Nishimura, RESPIROLOGY, 18, 12, 12, 2013年11月
英語, 研究発表ペーパー・要旨（国際会議）

肺高血圧患者における右心室酸素代謝亢進は右心室容量の増加よりも肺血管抵抗の上昇と強く関連する
吉永恵一郎, 伊藤陽一, 大平洋, 辻野一三, 真鍋治, 加藤千恵次, 佐藤隆博, 真鍋徳子, 藤井聡, 西村正治, 玉木長良, 核医学, 50, 3, 214, 2013年09月30日
日本語

Gene scoring model to predict recurrence in low- and intermediate-risk uterine endometrial cancer: Establishment of uterine print
Tatsuyuki Chiyoda, Yoichi M. Ito, Fumio Kataoka, Wataru Yamagami, Hiroyuki Nomura, Hiroshi Tsuda, Hideo Tanaka, Masashi Takano, Sadako Nishimura, Yoko Iguchi, Shiho Hashimoto, Tomoko Yoshihama, Nobuyuki Susumu, Daisuke Aoki, JOURNAL OF CLINICAL ONCOLOGY, 31, 15, 2013年05月
英語, 研究発表ペーパー・要旨（国際会議）

有機フッ素化合物(11種類)の胎児期曝露による出生時体格への影響　　　　　　　　　　　　　　　
樫野 いく子, 佐々木 成子, 岡田 恵美子, 宮下 ちひろ, 山本 潤, 松浦 英幸, 伊藤 陽一, 松村 徹, 玉腰 暁子, 岸 玲子, 日本衛生学雑誌, 68, Suppl., S160, S160, 2013年03月
日本衛生学会, 日本語

有機フッ素化合物の胎児期曝露による1歳までのアレルギー症状との関連　　　　　　　　　　　　　　　
岡田 恵美子, 樫野 いく子, 佐々木 成子, 宮下 ちひろ, 山本 潤, 伊藤 陽一, 松浦 英幸, 松村 徹, 玉腰 暁子, 岸 玲子, 日本衛生学雑誌, 68, Suppl., S161, S161, 2013年03月
日本衛生学会, 日本語

Co-overexpression of GEP100 With EGFR Correlates With Early Recurrence After Breast Conservation Therapy (BCT)
R. Kinoshita, J. Nam, M. Hosoda, C. Kubota K, M. Tanino, A. Hashimoto, Y. M. Ito, S. Tanaka, H. Sabe, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 84, 3, S227, S228, 2012年11月
英語, 研究発表ペーパー・要旨（国際会議）

IMPROVING THE HEALTH OF JAPANESE WOMEN: ACCEPTANCE OF HPV VACCINATION IN MOTHERS OF ADOLESCENT GIRLS
S. Hanley, E. Yoshioka, Y. Ito, R. Konno, N. Sakuragi, R. Kishi, JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 65, A250, A251, 2011年08月
英語, 研究発表ペーパー・要旨（国際会議）

Annexin A5 is a potential biomarker for Alzheimer disease
Hitoshi Sohma, Mami Yamaguchi, Shin-ichi Imai, Kumiko Utsumi, Kyoichi Matsumoto, Hirohito Honda, Yuka Mizue, Masako Momma, Yoichi Ito, Yasuo Kokai, NEUROSCIENCE RESEARCH, 68, E66, E67, 2010年
英語, 研究発表ペーパー・要旨（国際会議）

【原発不明がん】 Interface on Cancer Therapy 原発巣同定のアルゴリズム
倉橋 一成, 中川 和彦, 西尾 和人, 伊藤 陽一, 大橋 靖雄, がん分子標的治療, 7, 3, 160, 165, 2009年07月
(株)メディカルレビュー社, 日本語

Prognostic factors of hepatocellular carcinoma with decompensated cirrhosis
Kazuhim Nouso, Yoichi M. Ito, Kenji Kuwaki, Shoji Uematsu, Kunflum Shiraga, Ryoichi Okamoto, Shinichiro Nakamura, Yoshiyuki Kobayashi, Yasuyuki Araki, Kohsaku Sakaguchi, Yasuo Ohashi, Kazuhide Yamamoto, GASTROENTEROLOGY, 134, 4, A365, A365, 2008年04月
英語, 研究発表ペーパー・要旨（国際会議）

cDNAマクロアレイデータ解析における正規化手法の性能評価(<特集1>医薬品の有効性・安全性)
倉橋 一成, 伊藤 陽一, 松山 裕, 大橋 靖雄, 西尾 和人, 日本統計学会誌. シリーズJ, 36, 2, 147, 163, 2007年03月
一般社団法人日本統計学会, 日本語

Prognostic value of ABCF2 in ovarian clear cell adenocarcinoma.
H Tsuda, YM Ito, K Ito, S Nishimura, N Yaegashi, MJ Birrer, Y Ohashi, Y Hashiguchi, RS Berkowitz, SC Mok, JOURNAL OF CLINICAL ONCOLOGY, 23, 16, 463S, 463S, 2005年06月
英語, 研究発表ペーパー・要旨（国際会議）

ABCF2 is a new biomarker of ovarian clear cell adenocarcinoma.
S Nishimura, H Tsuda, YM Ito, K Ito, N Yaegashi, MJ Birrer, Y Ohashi, Y Hashiguchi, WS Berkowitz, SC Mok, JOURNAL OF CLINICAL ONCOLOGY, 23, 16, 466S, 466S, 2005年06月
英語, 研究発表ペーパー・要旨（国際会議）

ファルネシールトランスフェレース阻害剤,R115777のトランスレーショナル・スタディ-臨床第I相試験における遺伝子発現プロファイル解析結果　　　　　　　　　　　　　　　
秋山 慶太, 中川 和彦, 山本 信之, 小宮 武文, 植島 久雄, 浅井 暁, 鶴谷 純司, 森山 あづさ, 児玉 圭司, 築山 正嗣, 米阪 仁雄, 宮崎 昌樹, 金田 裕靖, 倉田 宝保, 田村 研治, 西尾 和人, 大橋 靖雄, 伊藤 陽一, W David, 伊藤 博夫, 小林 豪太, 福岡 正博, 日本呼吸器学会雑誌, 41, 増刊, 81, 81, 2003年03月
(一社)日本呼吸器学会, 日本語

A-5 分子標的薬剤に対する用量反応性遺伝子の探索(ゲノム・遺伝解析)(2003年度統計関連学会連合大会記録(日本統計学会第71回大会))
伊藤 陽一, 大橋 靖雄, 日本統計学会誌, 33, 3, 414, 414, 2003年
日本統計学会, 日本語

Low dose dobutamine stress gated Tc-99m-tetrofosmin SPECT provides additional value for identification of myocardial viability - Comparison with stress-rest perfusion SPECT and F-18-FDG PET.
K Yoshinaga, C Katoh, K Noriyasu, S Yamada, Y Ito, Y Kuge, T Kohya, A Kitabatake, N Tamaki, JOURNAL OF NUCLEAR MEDICINE, 43, 5, 93P, 94P, 2002年05月
英語, 研究発表ペーパー・要旨（国際会議）

Quantitative assessment of myocardial blood flow and flow reserve with (99m)-Tc-MIBI: Comparison with the results of measured by O-15-water PET.
Y Ito, K Noriyasu, H Furuyama, Y Iwado, K Yoshinaga, C Katoh, M Mabuchi, Y Kuge, T Kohya, A Kitabatake, N Tamaki, JOURNAL OF NUCLEAR MEDICINE, 43, 5, 187P, 187P, 2002年05月
英語, 研究発表ペーパー・要旨（国際会議）

Diminished endthelium-dependent coronary artery vasodilator function in smokers in healthy young adults evaluated by O-15-labeled water positron emission tomography.
Y Iwado, K Yoshinaga, H Furuyama, Y Ito, K Noriyasu, C Katoh, Y Kuge, E Tsukamoto, N Tamaki, JOURNAL OF NUCLEAR MEDICINE, 43, 5, 51P, 51P, 2002年05月
英語, 研究発表ペーパー・要旨（国際会議）

Greater reduction of coronary vasodilator function in the remote areas in patients with myocardial infarction than those without infarction.
K Yoshinaga, C Katoh, K Noriyasu, H Furuyama, Y Ito, Y Kuge, T Kohya, A Kitabatake, N Tamaki, JOURNAL OF NUCLEAR MEDICINE, 43, 5, 52P, 52P, 2002年05月
英語, 研究発表ペーパー・要旨（国際会議）

Evaluation of myocardial flow reserve and endothelial function late after Kawasaki disease with O-15-water PET.
H Furuyama, Y Odagawa, C Katoh, Y Iwado, K Yoshinaga, Y Ito, K Noriyasu, M Mabuchi, Y Kuge, K Kobayashi, N Tamaki, JOURNAL OF NUCLEAR MEDICINE, 43, 5, 344P, 344P, 2002年05月
英語, 研究発表ペーパー・要旨（国際会議）

Decreased myocardial oxygen consumption and cardiac efficiency in dilated cardiomyopathy assessed by positron emission tomography with C-11 acetate.
K Noriyasu, K Yoshinaga, Y Ito, C Katoh, H Furuyama, Y Iwado, M Mabuchi, Y Kuge, T Kohya, A Kitabatake, N Tamaki, JOURNAL OF NUCLEAR MEDICINE, 43, 5, 189P, 189P, 2002年05月
英語, 研究発表ペーパー・要旨（国際会議）

Reduced coronary flow reserve and endothelial function after Kawasaki disease using O-15-water PET
H Furuyama, Y Odagawa, C Katoh, Y Iwado, K Yoshinaga, Y Ito, K Noriyasu, Y Kuge, N Tamaki, K Kobayashi, CIRCULATION, 104, 17, 515, 515, 2001年10月
英語, 研究発表ペーパー・要旨（国際会議）

Regional differences in optimal threshold for viability assessment by FDG-SPECT.
M Mabuchi, K Yoshinaga, K Morita, K Noriyasu, Y Ito, H Furuyama, Y Iwado, N Kubo, C Katoh, Y Kuge, N Tamaki, JOURNAL OF NUCLEAR MEDICINE, 42, 5, 180P, 180P, 2001年05月
英語, 研究発表ペーパー・要旨（国際会議）

Reduced coronary flow reserve in well controlled hypercholesterolemic patients without perfusion abnormality or coronary stenosis.
K Yoshinaga, C Katoh, K Noriyasu, H Furuyama, M Mabuchi, Y Iwado, Y Ito, Y Kuge, T Kohya, A Kitabatake, N Tamaki, JOURNAL OF NUCLEAR MEDICINE, 42, 5, 90P, 91P, 2001年05月
英語, 研究発表ペーパー・要旨（国際会議）

Quantitative analysis for myocardial glucose utilization ln patients with LV dysfunction by FDG dynamic positron tomography.
K Morita, K Yoshinaga, M Mabuchi, Y Ito, K Noriyasu, Y Kuge, C Katoh, T Kohya, A Kitabatake, N Tamaki, JOURNAL OF NUCLEAR MEDICINE, 42, 5, 53P, 53P, 2001年05月
英語, 研究発表ペーパー・要旨（国際会議）

Reduction of coronary flow reserve in the area with and without ischemia on stress perfusion spect in patients with coronary artery disease.
K Yoshinaga, C Katoh, K Noriyasu, H Furuyama, M Mabuchi, Y Iwado, Y Ito, Y Kuge, T Kohya, A Kitabatake, N Tamaki, JOURNAL OF NUCLEAR MEDICINE, 42, 5, 179P, 179P, 2001年05月
英語, 研究発表ペーパー・要旨（国際会議）

Transient LV dysfunction in ischemic myocardium due to post-exercise stunning not subendocardial hypoperfusion. Comparative study with exercise and pharmacological stress gated myocardial SPECT.
H Furuyama, Y Iwado, K Yoshinaga, M Mabuchi, Y Ito, K Noriyasu, N Tamaki, JOURNAL OF NUCLEAR MEDICINE, 42, 5, 179P, 179P, 2001年05月
英語, 研究発表ペーパー・要旨（国際会議）

観察研究データの統計解析-傾向スコアの活用-　　　　　　　　　　　　　　　
伊藤 陽一, 統計数理研究所
日本医師会ORCA管理機構シンポジウム, 2019年02月12日, 日本語, 口頭発表（招待・特別）
東京 日本, ［国内会議］

データベースの構築や観察研究をどのように進めていけばいいか　　　　　　　　　　　　　　　
伊藤 陽一, 統計数理研究所
高知大学臨床試験セミナー, 2019年01月22日, 日本語, 口頭発表（招待・特別）
高知 日本, ［国内会議］

JMP Proで混合効果モデルを使いこなそう　　　　　　　　　　　　　　　
伊藤 陽一, 統計数理研究所
Discovery Summit Japan 2018, 2018年11月16日, 日本語, 口頭発表（招待・特別）
東京 日本, ［国内会議］

医薬品評価における医学統計学の役割　　　　　　　　　　　　　　　
伊藤 陽一, 統計数理研究所
統計思考力育成事業 統計数理研究所 公開講演会 創薬のフロンティア データサイエンスの挑戦, 2018年11月01日, 日本語, 口頭発表（招待・特別）
立川 日本, ［国際会議］

医療分野のデータサイエンティスト：生物統計家ってどんな仕事　　　　　　　　　　　　　　　
伊藤 陽一, 統計数理研究所
一般社団法人データサイエンティスト協会シンポジウム, 2018年10月19日, 日本語, 口頭発表（招待・特別）
東京 日本, ［国内会議］

臨床研究におけるリアルワールドデータの統計解析　　　　　　　　　　　　　　　
伊藤 陽一, 統計数理研究所
第17回久留米大学バイオ統計フォーラム, 2018年10月05日, 日本語, 口頭発表（招待・特別）
福岡 日本, ［国内会議］

臨床試験におけるEstimandの考え方　　　　　　　　　　　　　　　
伊藤 陽一, 統計数理研究所
第7回DIA医薬品開発に携わる生物統計専門家でない方のための統計ワークショップ, 2018年09月03日, 日本語, 口頭発表（一般）
東京 日本, ［国内会議］

M&S概論　　　　　　　　　　　　　　　
伊藤 陽一, 統計数理研究所
医薬品開発のためのPPK・PD研究会 2018年セミナー M&Sコース, 2018年08月23日, 日本語, 口頭発表（一般）
横浜 日本, ［国内会議］

臨床研究における統計手法の高度化と医療健康データ科学研究センターの取り組み　　　　　　　　　　　　　　　
伊藤 陽一, 統計数理研究所
医療イノベーション推進センター研修会, 2018年06月26日, 日本語, 口頭発表（招待・特別）
神戸 日本, ［国内会議］