Funayama Emi
| Faculty of Medicine Specialized Medicine Reconstructive Surgery and Rehabilitation Medicine | Associate Professor |
| Hokkaido University Hospital | Associate Professor |
Last Updated :2025/06/07
■Researcher basic information
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Researcher number
- 10533630
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Educational Organization
- Bachelor's degree program, Departments of Medicine, School of Medicine
- Master's degree program, Graduate School of Medicine
- Doctoral (PhD) degree program, Graduate School of Medicine
■Career
Career
■Research activity information
Papers
- A novel mouse model for studies of burn wound conversion using a top hat–shaped brass template
Matsuda N, Sato C, Ishikawa K, Miura T, Funayama E, Yamamoto Y, Fuyama K, Ohnishi S, Maeda T
Burns, 51, 2, 107348, Mar. 2025, [Peer-reviewed]
English, Scientific journal - Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat Accelerates Wound Healing in a Mouse Hind limb Lymphedema Model.
Kosuke Ishikawa, Yoshitada Hoshino, Masayuki Osawa, Emi Funayama, Takahiro Miura, Masahiro Hojo, Yuki Sasaki, Satoru Sasaki, Yuhei Yamamoto, Taku Maeda
Advances in wound care, 24 Jan. 2025, [International Magazine]
English, Scientific journal, Objective: Drugs regulating hypoxia-inducible factor (HIF)-1α have not been investigated for wound healing in lymphedema. Therefore, we examined the effects of drug modulation of HIF-1α activity for wound healing in our previously developed mouse model of nonirradiated hind limb lymphedema. Approach: Mouse hind limb lymphedema models (n = 17) and a sham group (n = 6) were created using 8- to 10-week-old male C57BL/6N mice. Mice with hind limb lymphedema were randomized into experimental groups receiving roxadustat, 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1), or dimethyl sulfoxide and were given intraperitoneal injections every 2 days for up to 2 weeks. Four days after the surgery, an 8-mm diameter full-thickness skin wound was created in the hind limb. The number of days required for wound closure and the percentage of wounds closed were measured. Skin samples taken at wound creation were evaluated by histological and molecular analysis. Results: Administration of roxadustat accelerated wound healing, whereas YC-1 delayed it, with a significant decrease and increase in skin thickness, respectively. The relative mRNA expression of Hif1α, matrix metalloproteinase-3, and interleukin-6 was significantly higher in the roxadustat group and that of metalloproteinase-9 was significantly lower in the roxadustat group compared with the control group. Innovation: This study is the first to demonstrate delayed wound healing in a mouse model of hind limb lymphedema and the first to demonstrate the promotion of significant wound healing through the use of roxadustat. Conclusion: Roxadustat exerts wound-healing effects and may promote the regulation of extracellular matrix remodeling via gene expression in hind limb lymphedema wound models. - Synergistic anti-tumor effects of oncolytic virus and anti-programmed cell death protein 1 antibody combination therapy: For suppression of lymph node and distant metastasis in a murine melanoma model
Sasaki Y., Maeda T., Hojo M., Miura T., Ishikawa K., Funayama E., Okada K., Yamamoto Y.
Biochemical and Biophysical Research Communications, 740, 151011, Dec. 2024, [Peer-reviewed]
English, Scientific journal - Comparison of leg volume ratio between inguinal lymphadenectomy and inguino-pelvic lymphadenectomy in patients with skin cancer of the lower extremity
Taku Maeda, Kosuke Ishikawa, Toshihiko Hayashi, Hiroshi Furukawa, Takahiro Miura, Masahiro Hojo, Emi Funayama, Yuhei Yamamoto
Journal of Plastic, Reconstructive & Aesthetic Surgery, 99, 397, 405, Elsevier BV, Dec. 2024
Scientific journal - Physiological and Functional Restoration of the Modiolus Using a Double Tendon Sling in Patients With Full-Thickness Oral Defects
Taku Maeda, Toshihiko Hayashi, Kosuke Ishikawa, Takahiro Miura, Emi Funayama, Yuhei Yamamoto
Annals of Plastic Surgery, Ovid Technologies (Wolters Kluwer Health), 18 Oct. 2024
Scientific journal, Background
Reconstruction of the oral modiolus should be considered for facial defects involving the lip and cheek. We have performed free flap reconstruction using a novel technique that includes a vertical and a horizontal sling for full-thickness defects involving the oral commissure.
Patients and Methods
We used a free radial forearm flap and the palmaris longus tendon to correct lip and cheek defects in 6 patients (3 men, 3 women; age, 55–84 years). The tendon was divided into 2 portions for use as the double sling. One sling was used to connect the upper and lower stumps of the orbicularis oris in the vertical direction and the other to connect the vertical sling and masseter muscle. The outcomes assessed were esthetic appearance and functional results.
Results
The facial defects ranged in size from 3.0 cm × 4.0 cm to 7.0 cm × 6.0 cm and the mucosal defects from 1.5 cm × 4.0 cm to 6.5 cm × 5.0 cm. The length of the harvested tendon ranged from 11.5 to 13.5 cm. All flaps survived without complications. Good esthetic outcomes were achieved (excellent facial appearance, n = 1; no lip deviation or drooping, n = 5). Functionally, all patients had acceptable mouth opening and were able to eat a regular diet.
Conclusions
Good physiological and functional results can be achieved using a double tendon sling for reconstruction of the modiolus in patients with full-thickness defects involving the oral commissure. - Hypoxic culture enhances the antimicrobial activity of amnion-derived mesenchymal stem cells, thereby reducing bacterial load and promoting wound healing in diabetic mice
Riku Ishii, Shunsuke Ohnishi, Masahiro Hojo, Kosuke Ishikawa, Emi Funayama, Takahiro Miura, Naoto Okubo, Kazufumi Okada, Yuhei Yamamoto, Taku Maeda
Biochemical and Biophysical Research Communications, 150903, 150903, Elsevier BV, Oct. 2024
Scientific journal - Distinct Roles of Omental and Latissimus Dorsi Flaps for Blocking Infection Pathways and Protecting A Left Ventricular Assist Device
Dongkyung Seo, Taku Maeda, Tomonori Ooka, Takahiro Miura, Kosuke Ishikawa, Emi Funayama, Satoru Wakasa, Yuhei Yamamoto
The Heart Surgery Forum, 27, 9, E998, E1002, Forum Multimedia Publishing LLC, 10 Sep. 2024
Scientific journal, Left ventricular assist devices (LVADs) are vital for managing severe heart failure in transplant-ineligible patients, but device exposure and infection pose significant challenges. This report details a 42-year-old man with dilated cardiomyopathy and bronchial asthma who presented with an externalized LVAD following a HeartMate II to HeartMate III exchange due to malfunction. Our tailored surgical strategy treated the LVAD driveline and main body as two distinct parts. This distinction is crucial, as major upstream infections typically originate from the driveline. We applied flaps to these parts for different purposes, maximizing their unique characteristics. The omental flap, chosen for its flexibility, blood supply, and immunological activation upon foreign body contact, covered the driveline. The latissimus dorsi flap provided vascularity and mechanical protection for the LVAD. Additionally, we review the omentum's basic physiological aspects, which are often unfamiliar to clinicians. Infection has not recurred in 6 months postoperatively, demonstrating the approach's effectiveness. - 乳房に生じた線維肉腫成分を伴う隆起性皮膚線維肉腫の1例
福田 摩莉佳, 石川 耕資, 前田 拓, 三浦 隆洋, 三田村 真太郎, 岡田 宏美, 舟山 恵美, 山本 有平
形成外科, 67, 9, 990, 998, 克誠堂出版(株), Sep. 2024
Japanese - Leukocytoclastic Vasculitis-Induced Lower Leg Ulceration in the Course of Immune Checkpoint Inhibitor Therapy for Advanced Malignant Melanoma: A Case Report
Dongkyung Seo, Shin Ariga, Kosuke Ishikawa, Takahiro Miura, Rika Moku, Emi Funayama, Yuhei Yamamoto, Taku Maeda
Journal of Wound Management and Research, 20, 2, 168, 172, Korean Wound Management Society, 30 Jun. 2024
Scientific journal, Immune checkpoint inhibitors (ICIs) have expanded therapeutic options for advanced malignancies, offering new hope for conditions once deemed untreatable. However, the advent of ICIs has introduced a spectrum of immune-related adverse events (irAEs), including leukocytoclastic vasculitis (LCV), a rare but significant complication. This case report describes development of LCV after treatment with nivolumab and ipilimumab in a 70-year-old man with malignant melanoma, highlighting the diagnostic and management challenges of such irAEs. Despite extensive investigation, conventional pathology failed to identify the immune complexes typically associated with LCV. The clinical presentation, alongside a detailed medical history and the exclusion of infections, medications, and autoimmune diseases, was crucial in establishing a diagnosis. Ulcer resolution following discontinuation of ICI therapy and initiation of steroids further support the conclusion that LCV was an irAE in this patient. This case underscores the need for vigilant monitoring for irAEs for the variable onset after ICI therapy and the importance of thorough history-taking to guide diagnosis and treatment. With ICIs becoming increasingly prevalent in oncology, the incidence of ICI-induced ulcers like LCV is expected to rise, necessitating heightened awareness and multidisciplinary approaches to patient care. - 高周波溶解炉システムにより受傷した背部電撃傷の1例
石井 浩子, 村尾 尚規, 石川 耕資, 徐 東經, 開田 ひろみ, 三浦 隆洋, 前田 拓, 舟山 恵美, 山本 有平
熱傷, 50, 2, 61, 65, (一社)日本熱傷学会, Jun. 2024
Japanese - これからのリンパ浮腫治療 皮弁移行による鼠径・骨盤内リンパ節郭清術後の下肢リンパ浮腫発症予防効果についての検討
前田 拓, 北條 正洋, 石川 耕資, 舟山 恵美, 三浦 隆洋, 山本 有平
リンパ学, 47, 1, 45, 47, 日本リンパ学会, Jun. 2024
Japanese - Fluoroscopy- and endoscopy-guided transoral sclerotherapy using foamed polidocanol for oropharyngolaryngeal venous malformations in a hybrid operation room: A case series
Ishikawa K, Maeda T, Funayama E, Murao N, Miura T, Sasaki Y, Seo D, Mitamura S, Oide S, Yamamoto Y, Sasaki S
Journal of Clinical Medicine, 13, 8, 2369, 18 Apr. 2024, [Peer-reviewed], [Invited]
English, Scientific journal - Lymphatic drainage patterns of malignant skin tumors in the head and neck region: a single-center retrospective study
Nishio T, Maeda T, Ishikawa K, Murao N, Fuyama K, Yamamoto Y, Hayashi T
International Journal of Clinical Oncology, 30 Mar. 2024, [Peer-reviewed], [Domestic magazines]
English, Scientific journal - Refinement of Surgery for Postaxial Polysyndactyly of the Toes
Kosuke Ishikawa, Hiroshi Furukawa, Yuhei Yamamoto, Emi Funayama, Takahiro Miura, Taku Maeda
Annals of Plastic Surgery, Ovid Technologies (Wolters Kluwer Health), 27 Mar. 2024
Scientific journal, Purpose
Treatment for polysyndactyly of the toes aims at cosmetic improvement but the lateroplantar rotation of the new fifth toe remains challenging. This study evaluated our novel surgical procedure for postaxial polysyndactyly of the toes.
Materials and Methods
Patients with postaxial polysyndactyly involving the fourth, fifth, and sixth toes treated in 2007 to 2017 with a minimum follow-up duration of 1 year were retrospectively investigated. Our aims of surgery for this condition were to avoid excessive lateroplantar rotation of the new fifth toe by using a proximally elongated plantar “shark-fin flap” and to make the tip of this toe appear to be naturally pointing inward by using the dog-ear component of the flap on the tip of the toe. The excess skin of the shark-fin flap was grafted onto the lateral surface of the fourth toe. Lateroplantar rotation of the fifth toe in these patients was compared with that in photographs of the feet of 96 normal 4-year-old children.
Results
A total of 11 feet in 10 patients (6 male, 4 female; mean age 1.3 years) were analyzed. Syndactyly between the fourth and fifth toes was complete in 3 feet, incomplete at the level of the distal interphalangeal joint of the fifth toe in 5, and incomplete at the level of the proximal interphalangeal joint of the fifth toe in 3. Lateroplantar rotation of the fifth toe, evaluated by the mean angle between 2 intersecting lines extending from the proximal nail fold of the third and fifth toes, was 25 ± 10° in normal feet and 0 ± 12° in operated feet with polysyndactyly. The absolute left-right difference in this angle was 7 ± 5° in normal children and 22 ± 12° in patients with polysyndactyly. Valgus deformity of the new fifth toe improved in all patients during a mean postoperative follow-up of 3.8 years.
Conclusions
Using our procedure, no excessive lateroplantar rotation has been observed when the tip of the fifth toe is inclined inward using a dog-ear flap component. This procedure could be useful in patients in whom the cosmetic outcome is a priority. - Negative Pressure Wound Therapy with Instillation and Dwell Time in Patients on Hemodialysis
Erika Guilpain Kusajima, Kosuke Ishikawa, Emi Funayama, Takahiro Miura, Katsumi Horiuchi, Suguru Matsui, Tatsuya Saito, Hotaka Matsui, Yuhei Yamamoto, Taku Maeda
International Journal of Surgical Wound Care, 5, 1, 1, 7, Japan Society for Surgical Wound Care, 01 Mar. 2024
Scientific journal - Intranodal lymphangiography with lipiodol as a diagnostic and therapeutic approach for spontaneous cervical chyle leak
Sasaki Y, Sakuhara Y, Sasaki S, Maeda T, Yamamoto Y, Ishikawa K
Clinical Case Reports, 11, 12, e8161, 19 Dec. 2023, [Peer-reviewed]
English, Scientific journal - Burn conversion possibly caused by COVID-19 infection: A case report
Dongkyung Seo, Taku Maeda, Yuhei Yamamoto, Emi Funayama, Takahiro Miura, Norifumi Matsuda, Kosuke Ishikawa
Burns Open, Elsevier BV, Dec. 2023
Scientific journal - Partially involuting congenital hemangioma with pyogenic granuloma‐induced rapid progression following incisional biopsy in infancy: A case report
Yuki Sasaki, Kosuke Ishikawa, Takahiro Miura, Emi Funayama, Yuhei Yamamoto, Taku Maeda
Clinical Case Reports, 11, 10, Wiley, 17 Oct. 2023
Scientific journal, Key Clinical Message
We present a case of partially involuting congenital hemangioma (PICH) that showed rapid growth with ulceration after incisional biopsy. PICH does not typically grow after birth. However, if growth occurs due to stimuli like biopsy, it is essential to consider the possibility of pyogenic granuloma complication. - Targeted next-generation sequencing for detection of PIK3CA mutations in archival tissues from patients with Klippel–Trenaunay syndrome in an Asian population
Yuki Sasaki, Kosuke Ishikawa, Kanako C. Hatanaka, Yumiko Oyamada, Yusuke Sakuhara, Tadashi Shimizu, Tatsuro Saito, Naoki Murao, Tomohiro Onodera, Takahiro Miura, Taku Maeda, Emi Funayama, Yutaka Hatanaka, Yuhei Yamamoto, Satoru Sasaki
Orphanet Journal of Rare Diseases, 18, 1, Springer Science and Business Media LLC, 04 Sep. 2023
Scientific journal, Abstract
Background
Klippel–Trenaunay syndrome (KTS) is a rare slow-flow combined vascular malformation with limb hypertrophy. KTS is thought to lie on the PIK3CA-related overgrowth spectrum, but reports are limited. PIK3CA encodes p110α, a catalytic subunit of phosphatidylinositol 3-kinase (PI3K) that plays an essential role in the PI3K/AKT/mammalian target of rapamycin (mTOR) signaling pathway. We aimed to demonstrate the clinical utility of targeted next-generation sequencing (NGS) in identifying PIK3CA mosaicism in archival formalin-fixed paraffin-embedded (FFPE) tissues from patients with KTS.
Results
Participants were 9 female and 5 male patients with KTS diagnosed as capillaro-venous malformation (CVM) or capillaro-lymphatico-venous malformation (CLVM). Median age at resection was 14 years (range, 5–57 years). Median archival period before DNA extraction from FFPE tissues was 5.4 years (range, 3–7 years). NGS-based sequencing of PIK3CA achieved an amplicon mean coverage of 119,000x. PIK3CA missense mutations were found in 12 of 14 patients (85.7%; 6/8 CVM and 6/6 CLVM), with 8 patients showing the hotspot variants E542K, E545K, H1047R, and H1047L. The non-hotspot PIK3CA variants C420R, Q546K, and Q546R were identified in 4 patients. Overall, the mean variant allele frequency for identified PIK3CA variants was 6.9% (range, 1.6–17.4%). All patients with geographic capillary malformation, histopathological lymphatic malformation or macrodactyly of the foot had PIK3CA variants. No genotype–phenotype association between hotspot and non-hotspot PIK3CA variants was found. Histologically, the vessels and adipose tissues of the lesions showed phosphorylation of the proteins in the PI3K/AKT/mTOR signaling pathway, including p-AKT, p-mTOR, and p-4EBP1.
Conclusions
The PI3K/AKT/mTOR pathway in mesenchymal tissues was activated in patients with KTS. Amplicon-based targeted NGS could identify low-level mosaicism from low-input DNA extracted from FFPE tissues, potentially providing a diagnostic option for personalized medicine with inhibitors of the PI3K/AKT/mTOR signaling pathway. - Development of a simultaneous and noninvasive measuring method using high-frame rate videography and motion analysis software for the assessment of facial palsy recovery in a rat model
Takahiro Miura, Yuhei Yamamoto, Emi Funayama, Kosuke Ishikawa, Taku Maeda
Journal of Plastic, Reconstructive & Aesthetic Surgery, 82, 211, 218, Elsevier BV, Jul. 2023
Scientific journal - Utility of Color Doppler Ultrasonography in Monitoring of a Free Jejunal Flap
Taku Maeda, Kosuke Ishikawa, Yoichiro Oda, Satoshi Kano, Nayuta Tsushima, Tomohiro Sakashita, Akihiro Homma, Yuhei Yamamoto, Emi Funayama
The Laryngoscope, Wiley, 29 Jun. 2023
Scientific journal - 皮膚欠損用創傷被覆材Sorbactコンプレスを用いた広範囲熱傷デブリードマン後の局所療法
石川 耕資, 北條 正洋, 星野 善允, 石井 浩子, 石井 陸, 佐々木 雄輝, 徐 東經, 松田 識郁, 三浦 隆洋, 前田 拓, 舟山 恵美, 山本 有平
熱傷, 49, 2, 103, 103, (一社)日本熱傷学会, Jun. 2023
Japanese - Therapeutic Potential of the Prolyl Hydroxylase Inhibitor Roxadustat in a Mouse Hindlimb Lymphedema Model
Yoshitada Hoshino, Masayuki Osawa, Emi Funayama, Kosuke Ishikawa, Takahiro Miura, Masahiro Hojo, Yuhei Yamamoto, Taku Maeda
Lymphatic Research and Biology, 21, 4, 372, 380, Mary Ann Liebert Inc, 07 Mar. 2023
Scientific journal - Effectiveness and safety of percutaneous sclerotherapy using absolute ethanol and/or polidocanol for maxillofacial venous malformations involving the masticatory muscles: A case series
Kosuke Ishikawa, Satoru Sasaki, Hiroshi Furukawa, Taku Maeda, Takahiro Miura, Yuki Sasaki, Yuhei Yamamoto, Emi Funayama
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 135, 3, 355, 362, Elsevier BV, Mar. 2023
Scientific journal - Efficacy of hyperbaric oxygen after microtia reconstruction using costal cartilage: A retrospective case-control study
Naoki Murao, Akihiko Oyama, Yuhei Yamamoto, Emi Funayama, Kosuke Ishikawa, Taku Maeda
Undersea and Hyperbaric Medicine, Undersea and Hyperbaric Medical Society (UHMS), 01 Jan. 2023
Scientific journal, Introduction: Microtia reconstruction with autologous costal cartilage framework grafting is challenging because the three-dimensional structure of the ear is highly complex, and meeting the high aesthetic demands of patients can be difficult. If the skin flap overlying the framework is thinned to achieve a smooth and accentuated outline, a poor blood supply in the thin skin flap may lead to skin necrosis, exposure of the framework, and poor surgical results. Hyperbaric oxygen (HBO2) therapy can promote the healing of complex wounds and flaps. This study sought to determine the effectiveness of HBO2 therapy for prevention of postoperative complications after framework grafting in microtia reconstruction. Methods: We retrospectively evaluated postoperative complications and compared outcomes in pediatric patients who underwent costal cartilage grafting for microtia reconstruction at our institution between 2011 and 2015 according to whether or not they received postoperative HBO2 therapy. HBO2 therapy was applied once daily for a total of 10 sessions starting on the first postoperative day. Results: During the study period, eight patients received HBO2 therapy after costal cartilage grafting and 12 did not. There was no significant difference in the incidence of postoperative ulcers. However, the incidence of framework exposure was lower and the healing time was shorter in patients who received HBO2 therapy than in those who did not. Discussion: HBO2 therapy can be used safely in pediatric patients to reduce postoperative complications and improve the aesthetic outcome of microtia reconstruction. After costal cartilage grafting, HBO2 therapy should be considered as adjuvant therapy. - ProPlan CMFを用いた術前3Dシミュレーションに基づく下顎再建の経験
北條 正洋, 前田 拓, 三浦 隆洋, 石川 耕資, 大澤 昌之, 舟山 恵美, 足利 雄一, 山本 有平
日本マイクロサージャリー学会学術集会プログラム・抄録集, 49回, 222, 222, (一社)日本マイクロサージャリー学会, Dec. 2022
Japanese - Sentinel node restoration by vascularized lymph node transfer in mice
Erika G. Kusajima, Yuhei Yamamoto, Kosuke Ishikawa, Takahiro Miura, Emi Funayama, Masayuki Osawa, Ryo Takagi, Taku Maeda
Microsurgery, Wiley, 02 Nov. 2022
Scientific journal - 腓骨再建における術前3Dシミュレーションの活用
石井 陸, 前田 拓, 三浦 隆洋, 石川 耕資, 舟山 恵美, 山本 有平
日本頭蓋顎顔面外科学会学術集会プログラム・抄録集, 40回, 136, 136, (一社)日本頭蓋顎顔面外科学会, Nov. 2022
Japanese - Restoration of lymph flow by flap transfer can prevent severe lower extremity lymphedema after inguino-pelvic lymphadenectomy
Taku Maeda, Yuhei Yamamoto, Toshihiko Hayashi, Hiroshi Furukawa, Kosuke Ishikawa, Takahiro Miura, Masahiro Hojo, Emi Funayama
Surgery Today, 53, 5, 588, 595, Springer Science and Business Media LLC, 29 Oct. 2022
Scientific journal - Streptococcal Toxic Shock Syndrome in a Pediatric Patient With Intramuscular Venous Malformation in the Neck
Norifumi Matsuda, Kosuke Ishikawa, Emi Funayama, Shintaro Mitamura, Satoru Sasaki, Yuhei Yamamoto, Taku Maeda
The Journal of Emergency Medicine, Elsevier BV, Oct. 2022
Scientific journal - チームサージャリーにおける形成外科の貢献 新型コロナウイルス感染症が及ぼした影響
松田 識郁, 石川 耕資, 前田 拓, 大澤 昌之, 舟山 恵美, 村尾 尚規, 林 利彦, 山本 有平
日本形成外科学会会誌, 42, 7, 369, 374, (一社)日本形成外科学会, Jul. 2022
Japanese - 好酸球性多発血管炎性肉芽腫症に伴う神経障害によって足部潰瘍を生じた1例
石井 陸, 村尾 尚規, 石川 耕資, 舟山 恵美, 前田 拓, 大澤 昌之, 山本 有平
創傷, 13, 3, 124, 127, (一社)日本創傷外科学会, Jul. 2022
Japanese - チームサージャリーにおける形成外科の貢献 新型コロナウイルス感染症が及ぼした影響
松田 識郁, 石川 耕資, 前田 拓, 大澤 昌之, 舟山 恵美, 村尾 尚規, 林 利彦, 山本 有平
日本形成外科学会会誌, 42, 7, 369, 374, (一社)日本形成外科学会, Jul. 2022
Japanese - リンパ節移植という局所外科的リンパ系再構築法がもたらす可能性 循環と免疫の観点から
前田 拓, 石川 耕資, 村尾 尚規, 林 利彦, 古川 洋志, 舟山 恵美, 大澤 昌之, 山本 有平
リンパ学, 45, 1, 38, 41, 日本リンパ学会, Jun. 2022
Japanese - 粉瘤様の外観を呈したPrimary dermal melanomaの治療経験
草島 英梨香, 前田 拓, 石川 耕資, 三浦 隆洋, 舟山 恵美, 大澤 昌之, 吉田 哲也, 山本 有平
日本臨床皮膚外科学会総会・学術大会プログラム・抄録集, 40回, 31, 31, 日本臨床皮膚外科学会, May 2022
Japanese - 遊離空腸再建における合併症早期発見のためのカラーエコーの有用性について
前田 拓, 林 利彦, 石川 耕資, 北條 正洋, 舟山 恵美, 三浦 隆洋, 山本 有平
頭頸部癌, 48, 2, 180, 180, (一社)日本頭頸部癌学会, May 2022
Japanese - 顕微鏡下マウスリンパ節移植モデルの開発 新たな材料を求めて
北條 正洋, 前田 拓, 石川 耕資, 大澤 昌之, 舟山 恵美, 山本 有平
日本マイクロサージャリー学会学術集会プログラム・抄録集, 48回, 355, 355, (一社)日本マイクロサージャリー学会, Dec. 2021
Japanese - Combined internal and external negative pressure wound therapy: breakthrough treatment for lymphocutaneous intractable fistula
Takahiro Miura, Yuhei Yamamoto, Naoki Murao, Taku Maeda, Masayuki Osawa, Toshihiko Hayashi, Emi Funayama
Surgery Today, 51, 10, 1630, 1637, Springer Science and Business Media LLC, Oct. 2021
Scientific journal - 遊離広背筋弁で再建した頭蓋骨に及ぶIII度熱傷の1例
竹田 朋弘, 石川 耕資, 林 利彦, 前田 拓, 石井 陸, 佐々木 雄輝, 北條 正洋, 三浦 隆洋, 大澤 昌之, 舟山 恵美, 山本 有平
熱傷, 47, 3, 114, 121, (一社)日本熱傷学会, Sep. 2021
Japanese - リンパ浮腫に対する最新研究と治療戦略 マウスリンパ節移植モデル リンパ節移植の循環系・免疫系作用に関する基礎研究
石川 耕資, 前田 拓, 草島 英梨香, 舟山 恵美, 林 利彦, 大澤 昌之, 古川 洋志, 山本 有平
リンパ学, 44, 1, 24, 27, 日本リンパ学会, Jul. 2021
Japanese - Breast reconstruction via fat grafting for a patient with bilateral congenital amastia ( Finlay‐Marks syndrome)
Riri Ito, Yuhei Yamamoto, Taku Maeda, Kosuke Ishikawa, Emi Funayama
Congenital Anomalies, 61, 4, 142, 143, Wiley, Jul. 2021
Scientific journal - リンパ浮腫に対する最新研究と治療戦略 マウスリンパ節移植モデル リンパ節移植の循環系・免疫系作用に関する基礎研究
石川 耕資, 前田 拓, 草島 英梨香, 舟山 恵美, 林 利彦, 大澤 昌之, 古川 洋志, 山本 有平
リンパ学, 44, 1, 24, 27, 日本リンパ学会, Jul. 2021
Japanese - Topical Application of Conditioned Medium from Hypoxically Cultured Amnion-Derived Mesenchymal Stem Cells Promotes Wound Healing in Diabetic Mice.
Hiroko Takahashi, Shunsuke Ohnishi, Yuhei Yamamoto, Toshihiko Hayashi, Naoki Murao, Masayuki Osawa, Taku Maeda, Kosuke Ishikawa, Naoya Sakamoto, Emi Funayama
Plastic and reconstructive surgery, 147, 6, 1342, 1352, 01 Jun. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: Mesenchymal stem cells or their conditioned medium improve chronic wound healing, and their effect is enhanced by hypoxia. Diabetic foot ulcers are chronic wounds characterized by abnormal and delayed healing, which frequently require amputation. The authors evaluated the effect of topical application of conditioned medium from hypoxically cultured amnion-derived mesenchymal stem cells on wound healing in diabetic mice. METHODS: Amnion-derived mesenchymal stem cells were cultured under 21% oxygen to prepare normoxic conditioned medium and under 1% oxygen to prepare hypoxic conditioned medium. Hydrogels containing standard medium, normoxic conditioned medium, or hypoxic conditioned medium were topically applied to excisional wounds of mice with streptozotocin-induced diabetes. Ulcer tissues were harvested on day 9; immunohistochemical and quantitative polymerase chain reaction analyses were performed to analyze angiogenesis, inflammatory cell infiltration, and expression levels of inflammation-related genes. RESULTS: Hypoxic conditioned medium significantly enhanced wound closure, increased capillary density and epithelization, and reduced macrophage infiltration. It also tended to reduce the infiltration of neutrophils and enhance the infiltration of regulatory T cells; it showed a tendency to downregulate the expression of the inflammation-related genes interleukin-1β, interleukin-6, chemokine ligand 1, and chemokine ligand 2. Normoxic conditioned medium exhibited similar effects, although they were of lesser magnitude than those of hypoxic conditioned medium. CONCLUSIONS: Hydrogels containing hypoxically cultured, amnion-derived mesenchymal stem cell conditioned medium accelerated wound healing in diabetic mice by enhancing angiogenesis, accelerating epithelization, and suppressing inflammation. Therefore, topical application of amnion mesenchymal stem cell-derived hypoxic conditioned medium could be a novel treatment for diabetic foot ulcers. - Cleft lip in oto-palato-digital syndrome type I.
Erika Guilpain Kusajima, Taku Maeda, Naoki Murao, Emi Funayama, Yuhei Yamamoto
Congenital anomalies, 61, 3, 103, 104, May 2021, [International Magazine]
English, Scientific journal - Iatrogenic third-degree burn caused by off-label use of an infrared radiant heat lamp in a patient with accidental hypothermia
Kosuke Ishikawa, Taku Maeda, Toshihiko Hayashi, Ryuji Shichinohe, Naoki Murao, Masahiro Hojo, Riri Ito, Masayuki Osawa, Yuhei Yamamoto, Emi Funayama
Burns Open, 5, 1, 21, 24, Elsevier BV, Jan. 2021
Scientific journal - Maggot debridement therapy in critical limb ischaemia: a case study.
Taku Maeda, Yuhei Yamamoto, Naoki Murao, Toshihiko Hayashi, Chu Kimura, Suguru Matsui, Tatsuya Saito, Hotaka Matsui, Masayuki Osawa, Emi Funayama
Journal of wound care, 29, Sup12, S28-S32, 01 Dec. 2020, [International Magazine]
English, Scientific journal, OBJECTIVE: In critical limb ischaemia (CLI), first-line therapy is revascularisation, but alternative treatment options are needed in certain cases. Maggot debridement therapy (MDT) is historically considered to be contraindicated in ischaemic ulcers. Wound care in patients with CLI is becoming increasingly diverse with the development of novel revascularisation strategies; therefore, CLI now needs to be reconsidered as an indication for MDT. METHOD: We retrospectively reviewed five legs with CLI (five male, one female) treated with MDT between January 2013 and December 2017. Changes in skin perfusion pressure (SPP) around the ulcer before and after MDT were evaluated. One or two cycles of MDT were performed (eight in total). We also evaluated the proportion of necrotic tissue in the ulcer and the presence of exposed necrotic bone. The proportion of necrotic tissue in the ulcer was classified as NT 1+ (<25%), NT 2+ (25-50%), NT 3+ (50-75%) or NT 4+ (>75%). RESULTS: When the proportion of necrotic tissue was >50%, with no exposed necrotic bone in the wound, an increase in SPP was observed after five (62.5%) of eight cycles of MDT. And with a proportion of necrotic tissue of <25% and/or exposed necrotic bone in the wound, a decrease in SPP was observed after three (37.5%) of eight cycles. Wound healing was accelerated in the presence of increased SPP. CONCLUSION: Effective MDT with increased SPP requires an ulcerative state of necrotic tissue grade > NT 3+, with no exposed necrotic bone. - Long-term outcomes and recurrence-free interval after the treatment of keloids with a standardized protocol.
T Maeda, E Funayama, Y Yamamoto, N Murao, M Osawa, K Ishikawa, T Hayashi
Journal of tissue viability, 30 Nov. 2020, [International Magazine]
English, Scientific journal, BACKGROUND: Recurrence rates of keloids have generally been reported at one time point. However, the longer the duration after treatment, the greater the likelihood that such lesions will recur. In this study, we analysed the time to recurrence during long-term follow-up. MATERIAL AND METHODS: We retrospectively reviewed recurrence-free interval in 52 patients with keloid (age 8-79 years) who had been treated between June 2006 and January 2011 using a standardised protocol developed by our group. RESULTS: Mean duration of follow-up was 37.5 (range, 7-120) months in patients with keloid. Kaplan-Meier survival curves revealed a statistically significant difference in recurrence-free interval between ear keloids and keloids excluding ear keloids. Recurrence rate for keloids was high in the first 2 years after treatment. CONCLUSIONS: Kaplan-Meier analysis was useful for understanding the tendency of recurrence of keloids after treatment using a standardised protocol. - 「頭頸部の難渋する良性疾患I(NF-1、血管疾患)」 口唇部の動静脈奇形に対する硬化療法・手術・レーザーによる複合的治療の検討
石川 耕資, 村尾 尚規, 西尾 卓哉, 福田 摩莉佳, 竹田 朋弘, 藤田 宗純, 澤口 恵美, 舟山 恵美, 山本 有平, 佐々木 了
日本頭蓋顎顔面外科学会学術集会プログラム・抄録集, 38回, 83, 83, (一社)日本頭蓋顎顔面外科学会, Nov. 2020
Japanese - 口蓋の潰瘍を伴う乳児血管腫に対するプロプラノロール内服による診断的治療の経験
石川 耕資, 村尾 尚規, 西尾 卓哉, 福田 摩莉佳, 竹田 朋弘, 藤田 宗純, 澤口 恵美, 舟山 恵美, 山本 有平, 佐々木 了
日本頭蓋顎顔面外科学会学術集会プログラム・抄録集, 38回, 118, 118, (一社)日本頭蓋顎顔面外科学会, Nov. 2020
Japanese - A Comparison of Outcomes After Palatoplasty in Patients With Non-Syndromic Pierre Robin Sequence Versus Patients With Non-Syndromic Isolated Cleft Palate
Maeda Taku, Yuhei Yamamoto, Akihiko Oyama, Satoru Sasaki, Toshihiko Hayashi, Naoki Murao, Masayuki Osawa, Emi Funayama
The Journal of craniofacial surgery, 31, 8, 2231, 2234, NLM (Medline), 01 Nov. 2020
English, Scientific journal - A Comparison of Outcomes After Palatoplasty in Patients With Non-Syndromic Pierre Robin Sequence Versus Patients With Non-Syndromic Isolated Cleft Palate.
Maeda Taku, Yuhei Yamamoto, Akihiko Oyama, Satoru Sasaki, Toshihiko Hayashi, Naoki Murao, Masayuki Osawa, Emi Funayama
The Journal of craniofacial surgery, 13 Oct. 2020, [International Magazine]
English, Scientific journal, The purpose of this retrospective study was to compare outcomes of cleft palate repair in patients with non-syndromic Pierre Robin sequence (NS-PRS) versus those with non-syndromic isolated cleft palate (NS-ICP). Pierre Robin sequence (PRS) was defined as a diagnosis of the triad of microretrognathia, glossoptosis, and cleft palate, and the severity of PRS was assessed based on the presence of respiratory and feeding problems. All patients underwent palatoplasty between January 2000 and December 2011. The authors examined age at palatoplasty, type of cleft palate, fistula rate, velopharyngeal (VP) function, nasal emission, hypernasality, and need for secondary speech surgery, in addition to PRS severity in the NS-PRS patients. A total of 15 NS-PRS patients and 40 NS-ICP patients were reviewed. The incidence of VP dysfunction, nasal emission, hypernasality, and secondary speech surgery was not significantly different between the NS-PRS patients and NS-ICP patients. Age at palatoplasty was significantly different between the 2 groups (P = 0.012) but type of CP was not (P = 1.00). Only 2 NS-PRS patients were classified as category III (severe), and all of the NS-PRS patients who had VP insufficiency were classified as PRS severity category I (not severe). The findings of this study indicate that NS-PRS patients may not have worse outcomes than NS-ICP patients. - Ulcerated Infantile Hemangioma of the Hard Palate: Diagnostic Treatment With Oral Propranolol
Kosuke Ishikawa, Munezumi Fujita, Tomohiro Takeda, Shintaro Mitamura, Takuya Nishio, Emi Funayama, Toshihiko Hayashi, Masayuki Osawa, Taku Maeda, Yuhei Yamamoto, Satoru Sasaki
The Journal of craniofacial surgery, 31, 6, e600, e602, NLM (Medline), 01 Sep. 2020
English, Scientific journal - Ulcerated Infantile Hemangioma of the Hard Palate
Kosuke Ishikawa, Munezumi Fujita, Tomohiro Takeda, Shintaro Mitamura, Takuya Nishio, Emi Funayama, Toshihiko Hayashi, Masayuki Osawa, Taku Maeda, Yuhei Yamamoto, Satoru Sasaki
Journal of Craniofacial Surgery, Publish Ahead of Print, Ovid Technologies (Wolters Kluwer Health), 03 Jul. 2020
Scientific journal - カルシフィラキシーに対する創部ケア 周期的持続灌流を併用した陰圧閉鎖療法による新規アプローチ法(Wound Care for Calciphylaxis: A Novel Approach for Wound Management with Negative Pressure Wound Therapy with Instillation and Dwell Time)
Guilpain Kusajima Erika, Yamamoto Yuhei, Murao Naoki, Hayashi Toshihiko, Osawa Masayuki, Maeda Taku, Ishikawa Kosuke, Horiuchi Katsumi, Matsui Suguru, Saito Tatsuya, Matsui Hotaka, Funayama Emi
International Journal of Surgical Wound Care, 1, 1, 20, 26, (一社)日本創傷外科学会, Jun. 2020
English - Wound Care for Calciphylaxis
Erika Guilpain Kusajima, Yuhei Yamamoto, Naoki Murao, Toshihiko Hayashi, Masayuki Osawa, Taku Maeda, Kosuke Ishikawa, Katsumi Horiuchi, Suguru Matsui, Tatsuya Saito, Hotaka Matsui, Emi Funayama
International Journal of Surgical Wound Care, 1, 1, 20, 26, Japan Society for Surgical Wound Care, 2020
Scientific journal - Application of Negative-pressure Wound Therapy after Radical Excision of Soft Tissue Malignancy
Taku Maeda, Naoki Murao, Toshihiko Hayashi, Emi Funayama, Masayuki Osawa, Kosuke Ishikawa, Yuhei Yamamoto
International Journal of Surgical Wound Care, 1, 2, 47, 52, Japan Society for Surgical Wound Care, 2020
Scientific journal - 眼外胚葉症候群(Oculoectodermal syndrome)の治療経験
開田 ひろみ, 村尾 尚規, 舟山 恵美, 石川 耕資, 高橋 周子, 山本 有平
日本形成外科学会会誌, 39, 12, 623, 629, (一社)日本形成外科学会, Dec. 2019
Japanese - Squamous cell carcinoma arising in a chronic leg ulcer in Klippel-Trenaunay syndrome after the Charles procedure: A case with 40 years of follow up.
Ishikawa K, Funayama E, Yamamoto Y, Furukawa H, Hayashi T, Murao N, Osawa M, Maeda T, Fujita M, Sasaki S
The Journal of dermatology, 46, 11, e403, e405, Nov. 2019, [Peer-reviewed], [International Magazine]
English - Advancement Flap Using Excess Skin for Upper Eyelid Full-Thickness Defects.
Ito R, Maeda T, Yamamoto Y, Funayama E, Murao N, Osawa M, Ishikawa K, Ikeda M, Hayashi T
The Journal of craniofacial surgery, 30, 8, 2614, 2616, Nov. 2019, [Peer-reviewed] - 先天性顔面神経麻痺に対するネットワーク型神経再建を行った1例
古川 洋志, 山本 有平, 前田 拓, 林 利彦, 大澤 昌之, 舟山 恵美, 七戸 龍司
日本頭蓋顎顔面外科学会誌, 35, 3, 84, 88, (一社)日本頭蓋顎顔面外科学会, Sep. 2019
Japanese - Oculo-auriculo-fronto-nasal syndrome with duane retraction syndrome and dysplastic bony structure in the midline of nose
Ito R, Osawa M, Yamamoto Y, Murao N, Hayashi T, Maeda T, Ishikawa K, Oyama A, Funayama E
The Journal of Craniofacial Surgery, 30, 6, e576, e578, Sep. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Oculo-auriculo-fronto-nasal syndrome (OAFNS) is a rare anomaly characterized by features overlapping those of frontonasal dysplasia (FND) and the oculo-auriculo-vertebral spectrum (OAVS).1 The FND features malformation of frontonasal process-derived structures, characterized by anomalies in the central portion of the face. The OAVS is characterized by developmental anomalies of the first and second pharyngeal arches. The OAFNS is a condition with clinical features of both FND and OAVS. Here, the authors present the case of a male with OAFNS who not only exhibited typical OAFNS symptoms but also a dysplastic bony structure that bridged the anterior nasal spine and inferior nasal bones, and unilateral type 3 Duane retraction syndrome (absence of right-eye abduction). Abnormal nasal bones are characteristic of OAFNS; such abnormalities are absent from FND and OAVS. The authors reduced the dysplastic nasal bony structure via open external rhinoplasty, followed by lateral nasal osteotomy when he was 16 years of age. The nasal dorsum appeared natural after surgery and he was satisfied with the result. - Wound-healing problems associated with combined vascular malformations in Klippel–Trenaunay syndrome
Ishikawa K, Yamamoto Y, Funayama E, Furukawa H, Sasaki S
Advances in Wound Care, 8, 6, 246, 255, Jun. 2019, [Peer-reviewed], [Invited]
English, Scientific journal, Significance: In Klippel–Trenaunay syndrome (KTS), management of a wound in the affected limb can be difficult because of the underlying vascular malformations present. This review describes the characteristics of KTS with wound complications in light of the genetic and molecular mechanisms of the disease. Recent Advances: KTS is a slow-flow combined vascular malformation characterized by the triad of capillary malformation, venous malformation with or without lymphatic malformation, and limb overgrowth. KTS is encompassed within the phosphatidylinositol-4,5-bisphosphate3-kinase catalytic subunit alpha (PIK3CA)-related overgrowth spectrum (PROS), having recently been linked to activating mutations in the PIK3CA gene. This clearly has implications for both molecular diagnosis and potential treatment strategies for the disease. Critical Issues: KTS should be distinguished from Parkes Weber syndrome, a fast-flow-type combined vascular malformation with limb overgrowth. Individualized management is needed for KTS and should be focused on the treatment of symptoms. Future Directions: Targeted therapies that inhibit the phosphoinositide 3-kinase signaling pathway are a potential treatment option for PROS. - Changes in high endothelial venules in lymph nodes after vascularized and nonvascularized lymph node transfer in a murine autograft model.
Ishikawa K, Funayama E, Maeda T, Hayashi T, Murao N, Osawa M, Ito R, Furukawa H, Oyama A, Yamamoto Y
Journal of surgical oncology, 119, 6, 700, 707, May 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND AND OBJECTIVES: Vascularized lymph node transfer (LNT) is gaining popularity in the treatment of lymphedema. However, it is unclear whether the vascularization of transferred lymph nodes (LNs) contributes to functional improvement. High endothelial venules (HEVs) are specialized vessels that allow lymphocytes to enter LNs. In this study, we compared the numbers of HEVs and lymphocytes in LNs after vascularized and nonvascularized LNT. METHODS: Fifty mice were divided into three groups (group 1, pedicled vascularized LNT; group 2, pedicled nonvascularized LNT; group 3, free nonvascularized LNT). Afferent lymphatic reconnection was confirmed by patent blue staining. The transferred LNs were harvested 4 weeks after surgery. HEVs, B-cells, and T-cells were subjected to immunohistochemical staining and quantified. RESULTS: Afferent lymphatic reconnection was observed in 13 of 20 transferred LNs in group 1, 11 of 15 in group 2, and 7 of 15 in group 3. The ratio of dilated/total HEVs in transferred LNs with afferent lymphatic reconnection was significantly higher in group 1 than in groups 2 and 3. No significant differences in numbers of B-cells and T-cells were found in the transferred LNs. CONCLUSIONS: We found that more functional HEVs were preserved in cases with successful afferent lymphatic reconnection after vascularized LNT than after nonvascularized LNT. - Feasibility of pedicled vascularized inguinal lymph node transfer in a mouse model: A preliminary study.
Ishikawa K, Maeda T, Funayama E, Hayashi T, Murao N, Osawa M, Furukawa H, Oyama A, Yamamoto Y
Microsurgery, 39, 3, 247, 254, Mar. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: Vascularized lymph node transfer is becoming more common in the treatment of lymphedema, but suitable small animal models for research are lacking. Here, we evaluated the feasibility of pedicled vascularized inguinal lymph node transfer in mice. METHODS: Twenty-five mice were used in the study. An inguinal lymph node-bearing flap with a vascular pedicle containing the superficial caudal epigastric vessels was transferred into the ipsilateral popliteal fossa after excision of the popliteal lymph node. Indocyanine green (ICG) angiography was used to confirm vascularity of the flap. ICG lymphography was performed to evaluate lymphatic flow at 3 and 4 weeks postoperatively. Patent blue dye was injected into the ipsilateral hind paw to observe staining of the transferred lymph node at 4 weeks postoperatively. All transferred lymph nodes were then harvested and histologically evaluated by hematoxylin and eosin staining. RESULTS: In 16 of the 25 mice, ICG lymphography showed reconnection between the transferred lymph node and the afferent lymphatic vessels, as confirmed by patent blue staining. Histologically, these transferred lymph nodes with afferent lymphatic reconnection significantly regressed in size (0.37 ± 0.24 mm2 ) and showed clear follicle formation, whereas those without afferent lymphatic reconnection showed less size regression (1.31 ± 1.17 mm2 ); the cell population was too dense to allow identification of follicles. CONCLUSIONS: We established a mouse model of vascularized lymph node transfer with predictable afferent lymphatic reconnection. Both the vascularization and reconnection might be necessary for functional regeneration of the transferred lymph node. - NEDD4 Is Involved in Inflammation Development during Keloid Formation.
Fujita M, Yamamoto Y, Jiang JJ, Atsumi T, Tanaka Y, Ohki T, Murao N, Funayama E, Hayashi T, Osawa M, Maeda T, Kamimura D, Murakami M
The Journal of investigative dermatology, 139, 2, 333, 341, Feb. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Keloids mark a chronic inflammatory disease characterized by a fibroproliferative disorder of the skin. A genome-wide association study showed that single-nucleotide polymorphism rs8032158 in the neural precursor cell-expressed NEDD4 gene, which has six protein-coding transcript variants (TVs), is genetically linked to keloids. Here, we show that the high frequency of risk allele C in rs8032158 in keloid patients is associated with a selectively higher expression of TV3 of NEDD4 to activate the NF-κB pathway. Comparisons of keloid scars with normal skin samples that do not have the single-nucleotide polymorphism allele and were derived from different anatomical sites showed stronger expressions of NEDD4 TV3 and activated forms of NF-κB and STAT3 in keloid scars. Forced expression or selective knockdown of NEDD4 TV3 increased or decreased NF-κB activation in vitro. Furthermore, NEDD4 knockdown suppressed NF-κB-dependent inflammation development in vivo. Mechanistic analysis showed that NEDD4 TV3 is involved in NF-κB activation through its association with the adaptor protein RIP. These results suggest that NEDD4 TV3 is a potential diagnostic marker and therapeutic target for chronic skin diseases, including keloid. - Combination laser therapy as a non-surgical method for treating congenital melanocytic nevi from cosmetically sensitive locations on the body.
Funayama E, Yamamoto Y, Oyama A, Murao N, Hayashi T, Maeda T, Furukawa H, Osawa M
Lasers in medical science, 34, 9, 1925, 1928, Feb. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal - Comparison of Nasal Symmetry Between Presurgical Nasal Stenting and Postsurgical Nasal Retainer Placement in Unilateral Clefts.
Funayama E, Yamamoto Y, Oyama A, Furukawa H, Murao N, Hayashi T, Maeda T, Osawa M
The Journal of craniofacial surgery, 30, 1, 133, 136, Jan. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, The timing of cleft lip nose surgery remains controversial. The less invasive the procedure at the time of primary cleft lip repair, the less the growth and development of the nose is affected. Therefore, the nasal-stenting component of presurgical nasoalveolar molding has increasingly been used. However, not all cleft centers use such treatment. Conventional postsurgical placement of silicone nasal retainers remains popular. No report has yet compared presurgical nasal stenting (preNS) and postsurgical nasal retainer placement (postNR). In this study, postoperative nasal form outcomes after primary lip repair using preNS or postNR in patients with complete unilateral cleft lips, alveoli, and palates were compared. Patients in whom preNS alone was used for 6 months (group I) were compared with those receiving postNR (no preNS) for 6 months after primary nasal cartilage dissection (group II) and controls with no appliance (group III). Nasal anthropometric distances and angular relationships were measured photographically to assess nasal symmetry at 4 years of age in all groups. Compared to group III, groups I and II exhibited significantly greater nostril heights (P = 0.0075, P = 0.0015 respectively) and columellar deviation angles (P = 0.0020, P = 0.0221). Groups I and II did not differ significantly. No significant between-treatment difference in terms of nasal symmetry between preNS and postNR was observed. However, both treatments afforded significantly better results than no treatment. Since older infants tend to resist the placement of nasal devices, preNS is more feasible in this age group. - Our techniques for secondary alveolar bone grafting
Masayuki Osawa, Akihiko Oyama, Emi Funayama, Yuhei Yamamoto
Japanese Journal of Plastic Surgery, 61, 7, 824, 834, Kokuseido Publishing Co. Ltd, 01 Jul. 2018
Japanese, Scientific journal - チームサージャリーにおける形成外科の貢献に関する10年間の検討
石川 耕資, 古川 洋志, 小山 明彦, 舟山 恵美, 林 利彦, 村尾 尚規, 大澤 昌之, 前田 拓, 関堂 充, 山本 有平
日本形成外科学会会誌, 38, 6, 277, 282, (一社)日本形成外科学会, Jun. 2018
Japanese - [A 10-year analysis of the contribution of plastic surgeons to team surgery]
Kosuke Ishikawa, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Toshihiko Hayashi, Naoki Murao, Masayuki Osawa, Taku Maeda, Mitsuru Sekido, Yuhei Yamamoto
Journal of Japan Society of Plastic and Reconstructive Surgery, 38, 6, 277, 282, (一社)日本形成外科学会, Jun. 2018, [Peer-reviewed]
Japanese - 斗南病院における血管奇形患者116例の血液凝固系についての検討
藤田 宗純, 佐々木 了, 石川 耕資, 舟山 恵美, 山本 有平
日本形成外科学会会誌, 38, 4, 183, 191, (一社)日本形成外科学会, Apr. 2018
Japanese - Lymphatic Reconnection and Restoration of Lymphatic Flow by Nonvascularized Lymph Node Transplantation: Real-Time Fluorescence Imaging Using Indocyanine Green and Fluorescein Isothiocyanate-Dextran
Taku Maeda, Yuhei Yamamoto, Daisuke Iwasaki, Toshihiko Hayashi, Emi Funayama, Akihiko Oyama, Naoki Murao, Hiroshi Furukawa
Lymphatic Research and Biology, 16, 2, 165, 173, Mary Ann Liebert Inc., 01 Apr. 2018, [Peer-reviewed]
English, Scientific journal - Immune-mediated antitumor effect of a transplanted lymph node.
Maeda T, Hayashi T, Furukawa H, Iwasaki D, Ishikawa K, Funayama E, Murao N, Osawa M, Oyama A, Yamamoto Y
International journal of cancer, 143, 5, 1224, 1235, Mar. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, Lymph node (LN) transplantation is a recognized method for reconstruction of the lymphatic system and is used in the clinical setting to treat lymphedema. However, it is unclear whether transplanted LNs contribute to immune surveillance. In our study, we investigated whether a single transplanted non-vascularized LN, defined as a tumor-draining transplanted lymph node (TDTLN), could exert an immune-mediated antitumor effect. LN and lung metastases and primary tumor enlargement were evaluated in mice that were inoculated with B16-F10-luc2 melanoma cells in a hind limb footpad without (group 1) and with (group 2) popliteal lymph node (PLN) resection and in mice that underwent LN transplantation after PLN resection (group 3). The function of a TDTLN (group 3) and a tumor-draining popliteal lymph node (TDPLN; group 1) was evaluated in the context of cancer. LN and lung metastases were significantly aggravated by PLN resection but were significantly decreased by LN transplantation. Immunohistochemistry showed that the TDTLNs retained T-cells and B-cells and fluorescence-activated cell sorting analysis confirmed expansion of lymphocytes in these nodes; however, the degree of expansion in TDTLNs was different from that in TDPLNs. Expression of cytokines associated with immunostimulation was confirmed in the TDTLNs as well as in the TDPLNs. One of the differences in the immune-mediated antitumor effect of the TDPLNs and TDTLNs was ascribed to a difference in the site of lymphocyte homing to peripheral LNs through high endothelial venules. Non-vascularized LN transplantation had an immune-mediated antitumor effect. - Conditioned Medium Obtained from Amnion-Derived Mesenchymal Stem Cell Culture Prevents Activation of Keloid Fibroblasts.
Sato C, Yamamoto Y, Funayama E, Furukawa H, Oyama A, Murao N, Hosono H, Kawakubo K, Sakamoto N, Ohnishi S
Plastic and reconstructive surgery, 141, 2, 390, 398, Feb. 2018, [Peer-reviewed]
English, Scientific journal - Apert症候群との鑑別を要したoral-facial-digital syndrome type Iの1例
伊藤 梨里, 小山 明彦, 林 利彦, 舟山 恵美, 古川 洋志, 山本 有平
日本頭蓋顎顔面外科学会誌, 33, 4, 132, 136, (一社)日本頭蓋顎顔面外科学会, Dec. 2017
Japanese - Vesiculobullous melanoma: an unusual manifestation of in-transit metastasis
E. Kusajima, H. Furukawa, E. Funayama, A. Oyama, T. Mitsuhashi, Y. Yamamoto
CLINICAL AND EXPERIMENTAL DERMATOLOGY, 42, 7, 767, 770, Oct. 2017, [Peer-reviewed]
English, Scientific journal - Transarterial Embolization and Transmucosal Sclerotherapy That Led to Successful Deliveries in a Patient With Symptomatic Arteriovenous Malformation of the Tongue
Munezumi Fujita, Yuhei Yamamoto, Satoru Sasaki, Akihiko Oyama, Emi Funayama, Hiroshi Furukawa
JOURNAL OF CRANIOFACIAL SURGERY, 28, 7, E675, E678, Oct. 2017, [Peer-reviewed]
English, Scientific journal - Factors that Affected Functional Outcome After a Delayed Excision and Split-Thickness Skin Graft on the Dorsal Side of Burned Hands
Ryuji Shichinohe, Yuhei Yamamoto, Kunihiro Kawashima, Chu Kimura, Kentaro Ono, Katsumi Horiuchi, Tetsunori Yoshida, Naoki Murao, Toshihiko Hayashi, Emi Funayama, Akihiko Oyama, Hiroshi Furukawa
JOURNAL OF BURN CARE & RESEARCH, 38, 5, E851, E858, Sep. 2017, [Peer-reviewed]
English, Scientific journal - Dominant lymph drainage patterns in the occipital and parietal regions: evaluation of lymph nodes in patients with skin cancer of the head
Taku Maeda, Yuhei Yamamoto, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Naoki Murao, Toshihiko Hayashi
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 22, 4, 774, 779, Aug. 2017, [Peer-reviewed]
English, Scientific journal - 下顎再建後のプレート露出に対するVAC治療システムおよび高気圧酸素療法を用いた集学的治療
前田 拓, 林 利彦, 古川 洋志, 村尾 尚規, 小山 明彦, 舟山 恵美, 山本 有平
日本形成外科学会会誌, 37, 6, 332, 332, (一社)日本形成外科学会, Jun. 2017
Japanese - Hinged mastoid fascial flapを用いたトリーチャーコリンズ症候群のlow hairline microtiaの再建
前田 拓, 小山 明彦, 舟山 恵美, 古川 洋志, 林 利彦, 村尾 尚規, 山本 有平
日本形成外科学会会誌, 37, 6, 344, 344, (一社)日本形成外科学会, Jun. 2017
Japanese - Review and proposal of regional surgical management for melanoma: revisiting of integumentectomy and incontinuity dissection in treatment of skin melanoma
Toshihiko Hayashi, Hiroshi Furukawa, Takashi Kitamura, Ryuji Shichinohe, Naoki Murao, Akihiko Oyama, Emi Funayama, Taku Maeda, Yuhei Yamamoto
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 22, 3, 569, 576, Jun. 2017, [Peer-reviewed]
English - Full-Thickness Entire Nasal Alar Reconstruction Using a Forehead Flap in Asians: No Cartilaginous Infrastructural Lining Is Necessary
Emi Funayama, Yuhei Yamamoto, Hiroshi Furukawa, Naoki Murao, Ryuji Shichinohe, Takeshi Yamao, Toshihiko Hayashi, Akihiko Oyama
JOURNAL OF CRANIOFACIAL SURGERY, 28, 3, 734, 737, May 2017, [Peer-reviewed]
English, Scientific journal - Establishment of an Acquired Lymphedema Model in the Mouse Hindlimb: Technical Refinement and Molecular Characteristics
Daisuke Iwasaki, Yuhei Yamamoto, Naoki Murao, Akihiko Oyama, Emi Funayama, Hiroshi Furukawa
PLASTIC AND RECONSTRUCTIVE SURGERY, 139, 1, 67E, 78E, Jan. 2017, [Peer-reviewed]
English, Scientific journal - 3つのコンセプトを融合した片側唇裂口唇形成術の改良法 "ASSIST" technique
小山 明彦, 舟山 恵美, 古川 洋志, 林 利彦, 村尾 尚規, 七戸 龍司, 山本 有平
日本頭蓋顎顔面外科学会誌, 32, 3, 182, 182, (一社)日本頭蓋顎顔面外科学会, Oct. 2016
Japanese - 初回口蓋形成術後の言語成績の比較検討 非症候群性Pierre Robin Sequence VS非症候群性口蓋裂
前田 拓, 舟山 恵美, 小山 明彦, 古川 洋志, 林 利彦, 村尾 尚規, 七戸 龍司, 山本 有平
日本頭蓋顎顔面外科学会誌, 32, 3, 183, 183, (一社)日本頭蓋顎顔面外科学会, Oct. 2016
Japanese - 広範な先天性頭皮頭蓋骨欠損の治療経験 保存的治療か外科的治療か
前田 拓, 小山 明彦, 舟山 恵美, 古川 洋志, 林 利彦, 村尾 尚規, 七戸 龍司, 山本 有平
日本頭蓋顎顔面外科学会誌, 32, 3, 216, 216, (一社)日本頭蓋顎顔面外科学会, Oct. 2016
Japanese - Reconstruction of Large Cheek Defect With/Without Sideburn Using Malar-Posterior Auricular-Cervico Flap
Toshihiko Hayashi, Yuhei Yamamoto, Akihiko Oyama, Emi Funayama, Ryuji Shichinohe, Naoki Murao, Hiroshi Furukawa
ANNALS OF PLASTIC SURGERY, 77, 2, 173, 177, Aug. 2016, [Peer-reviewed]
English, Scientific journal - Exploration of more effective neurorrhaphy in facial nerve reconstruction: A comparison focusing on the difference of neural window size and condition of the neurorrhaphy site
Kentaro Ono, Yuhei Yamamoto, Ryuji Shichinohe, Naoki Murao, Akihiko Oyama, Emi Funayama, Hiroshi Furukawa
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 69, 8, 1072, 1079, Aug. 2016, [Peer-reviewed]
English, Scientific journal - 当院における過去5年間の児童虐待の実態と形成外科の役割
高橋 紀久子, 舟山 恵美, 本田 進, 北條 正洋, 木村 中
日本形成外科学会会誌, 36, 7, 304, 310, (一社)日本形成外科学会, Jul. 2016
Japanese - Reconstruction of low hairline microtia of Treacher Collins syndrome with a hinged mastoid fascial flap
T. Maeda, A. Oyama, E. Funayama, Y. Yamamoto
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 45, 6, 731, 734, Jun. 2016, [Peer-reviewed]
English, Scientific journal - 初回口蓋形成術後の鼻咽腔閉鎖不全と二次修正術について 非症候性Pierre Robin Sequenceと非症候性口蓋裂
前田 拓, 舟山 恵美, 小山 明彦, 古川 洋志, 林 利彦, 村尾 尚規, 七戸 龍司, 山本 有平
日本口蓋裂学会雑誌, 41, 2, 104, 104, (一社)日本口蓋裂学会, Apr. 2016
Japanese - Prevention of Lymphedematous Change in the Mouse Hindlimb by Nonvascularized Lymph Node Transplantation
Ryuta Shioya, Hiroshi Furukawa, Naoki Murao, Toshihiko Hayashi, Akihiko Oyama, Emi Funayama, Yuhei Yamamoto, Noriko Saito
ANNALS OF PLASTIC SURGERY, 76, 4, 442, 445, Apr. 2016, [Peer-reviewed]
English, Scientific journal - 小耳症耳介形成術後の皮膚潰瘍に対する治療戦略
小山 明彦, 古川 洋志, 舟山 恵美, 林 利彦, 村尾 尚規, 七戸 龍司, 山本 有平
日本形成外科学会会誌, 36, 3, 137, 137, (一社)日本形成外科学会, Mar. 2016
Japanese - 小耳症耳介形成術後の皮膚潰瘍の予防を目的とした高気圧酸素療法の有用性
小山 明彦, 塩谷 隆太, 古川 洋志, 舟山 恵美, 林 利彦, 村尾 尚規, 七戸 龍司, 山本 有平
日本形成外科学会会誌, 36, 3, 138, 138, (一社)日本形成外科学会, Mar. 2016
Japanese - Neuregulin-1 released by biodegradable gelatin hydrogels can accelerate facial nerve regeneration and functional recovery of traumatic facial nerve palsy
Go Yasui, Yuhei Yamamoto, Ryuji Shichinohe, Emi Funayama, Akihiko Oyama, Toshihiko Hayashi, Hiroshi Furukawa
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 69, 3, 328, 334, Mar. 2016, [Peer-reviewed]
English, Scientific journal - A new primary cleft lip repair technique tailored for Asian patients that combines three surgical concepts: Comparison with rotation-advancement and straight-line methods
Emi Funayama, Yuhei Yamamoto, Hiroshi Furukawa, Naoki Murao, Ryuji Shichinohe, Toshihiko Hayashi, Akihiko Oyama
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 44, 1, 27, 33, Jan. 2016, [Peer-reviewed]
English, Scientific journal - 美容外科教育 大学での美容外科教育の現状と課題 北海道大学病院における整容・美容外科の現状と教育の課題
舟山 恵美, 小山 明彦, 古川 洋志, 村尾 尚規, 七戸 龍司, 林 利彦, 山本 有平
日本美容外科学会会報, 37, 4, 137, 137, (一社)日本美容外科学会, Dec. 2015
Japanese - 北海道大学病院における急性期熱傷症例の過去5年間の検討
藤田 宗純, 村尾 尚規, 山尾 健, 七戸 龍司, 林 利彦, 舟山 恵美, 小山 明彦, 古川 洋志, 山本 有平, 丸藤 哲
熱傷, 41, 4, 202, 202, (一社)日本熱傷学会, Nov. 2015
Japanese - Tessier No.3およびNo.4の合併症例 12年間のフォローアップ
前田 拓, 小山 明彦, 岡本 亨, 舟山 恵美, 古川 洋志, 林 利彦, 村尾 尚規, 七戸 龍司, 山本 有平
日本頭蓋顎顔面外科学会誌, 31, 3, 247, 247, (一社)日本頭蓋顎顔面外科学会, Oct. 2015
Japanese - Effectiveness of intraoperative indocyanine-green fluorescence angiography during inguinal lymph node dissection for skin cancer to prevent postoperative wound dehiscence
Hiroshi Furukawa, Toshihiko Hayashi, Akihiko Oyama, Emi Funayama, Naoki Murao, Takeshi Yamao, Yuhei Yamamoto
SURGERY TODAY, 45, 8, 973, 978, Aug. 2015, [Peer-reviewed]
English, Scientific journal - 北海道大学病院における広範囲熱傷の治療戦略 形成外科医の立場から
藤田 宗純, 村尾 尚規, 七戸 龍司, 林 利彦, 舟山 恵美, 小山 明彦, 古川 洋志, 山本 有平, 宮本 大輔, 丸藤 哲
熱傷, 41, 2, 99, 99, (一社)日本熱傷学会, Jun. 2015
Japanese - 上眼瞼全層欠損に対する余剰皮膚を利用したadvancement flapによる再建
林 利彦, 古川 洋志, 七戸 龍司, 村尾 尚規, 小山 明彦, 舟山 恵美, 山本 有平
頭頸部癌, 41, 2, 215, 215, (一社)日本頭頸部癌学会, May 2015
Japanese - Dental Arch Relationship Outcomes in One- and Two-Stage Palatoplasty for Japanese Patients With Complete Unilateral Cleft Lip and Palate
Tadashi Mikoya, Toyoko Shibukawa, Takafumi Susami, Yoshiaki Sato, Toshimoto Tengan, Hirotaka Katashima, Akihiko Oyama, Yusuke Matsuzawa, Yumi Ito, Emi Funayama
CLEFT PALATE-CRANIOFACIAL JOURNAL, 52, 3, 277, 286, May 2015, [Peer-reviewed]
English, Scientific journal - Successful Conservative Management of a Large Congenital Scalp and Skull Defect
Taku Maeda, Akihiko Oyama, Emi Funayama, Hiroshi Furukawa, Kazutoshi Cho, Yuhei Yamamoto
JOURNAL OF CRANIOFACIAL SURGERY, 26, 3, E275, E277, May 2015, [Peer-reviewed]
English, Scientific journal - Dental arch relationship outcomes in one- and two-stage palatoplasty for Japanese patients with complete unilateral cleft lip and palate
Tadashi Mikoya, Toyoko Shibukawa, Takafumi Susami, Yoshiaki Sato, Toshimoto Tengan, Hirotaka Katashima, Akihiko Oyama, Yusuke Matsuzawa, Yumi Ito, Emi Funayama
Cleft Palate-Craniofacial Journal, 52, 3, 277, 286, American Cleft Palate Craniofacial Association, 01 May 2015, [Peer-reviewed]
English, Scientific journal - 片側性唇顎口蓋裂の術前顎矯正および一期手術 術前・術後の歯槽形態の変化について
岡本 亨, 小山 明彦, 舟山 恵美, 古川 洋志, 林 利彦, 村尾 尚規, 七戸 龍司, 山本 有平
日本口蓋裂学会雑誌, 40, 2, 111, 111, (一社)日本口蓋裂学会, Apr. 2015
Japanese - A case of combined soft tissue and intraosseous venous malformation of the thumb treated with sclerotherapy using a bone marrow aspiration needle.
Ishikawa K, Sasaki S, Furukawa H, Nagao M, Iwasaki D, Fujita M, Saito N, Oyama A, Yamamoto Y
Case reports in plastic surgery & hand surgery, 2, 2, 37, 39, Informa UK Limited, 2015, [Peer-reviewed]
Scientific journal - Combined therapy of NPWT and bipedicled flap as an alternative approach for giant abdominal wall defect with significant visceral edema: report of a case.
Yasui G, Furukawa H, Warabi T, Hayashi T, Oyama A, Funayama E, Yamamoto Y
Case reports in plastic surgery & hand surgery, 2, 2, 25, 28, 2015, [Peer-reviewed] - 下顎再建後のプレート露出に対するVAC治療システムおよび高気圧酸素療法を用いた集学的治療
前田 拓, 林 利彦, 古川 洋志, 七戸 龍司, 栗林 和代, 小野 貢伸, 村尾 尚規, 小山 明彦, 舟山 恵美, 山本 有平
日本マイクロサージャリー学会学術集会プログラム・抄録集, 41回, 166, 166, (一社)日本マイクロサージャリー学会, Dec. 2014
Japanese - Important points for primary cleft palate repair for speech derived from speech outcome after three different types of palatoplasty
Emi Funayama, Yuhei Yamamoto, Noriko Nishizawa, Tadashi Mikoya, Toru Okamoto, Satoko Imai, Naoki Murao, Hiroshi Furukawa, Toshihiko Hayashi, Akihiko Oyama
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 78, 12, 2127, 2131, Dec. 2014, [Peer-reviewed]
English, Scientific journal - Combination of Tessier clefts 3 and 4: Case report of a rare anomaly with 12 years' follow-up
Taku Maeda, Akihiko Oyama, Toru Okamoto, Emi Funayama, Hiroshi Furukawa, Toshihiko Hayashi, Naoki Murao, Yoshiaki Sato, Yuhei Yamamoto
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 42, 8, 1985, 1989, Dec. 2014, [Peer-reviewed]
English, Scientific journal - Treg-enriched CD4+T cells attenuate collagen synthesis in keloid fibroblasts
Naoki Murao, Ken-ichiro Seino, Toshihiko Hayashi, Masaki Ikeda, Emi Funayama, Hiroshi Furukawa, Yuhei Yamamoto, Akihiko Oyama
EXPERIMENTAL DERMATOLOGY, 23, 4, 266, 271, Apr. 2014, [Peer-reviewed]
English, Scientific journal - An Analysis of Cheek Reconstruction After Tumor Excision in Patients With Melanoma
Toshihiko Hayashi, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Akira Saito, Yuhei Yamamoto
JOURNAL OF CRANIOFACIAL SURGERY, 25, 2, E98, E101, Mar. 2014, [Peer-reviewed]
English, Scientific journal - Dominant lymph drainage in the upper extremity and upper trunk region: evaluation of lymph drainage in patients with skin melanomas
Toshihiko Hayashi, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Akira Saito, Yuhei Yamamoto
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 19, 1, 193, 197, Feb. 2014, [Peer-reviewed]
English, Scientific journal - Minor-Form/Microform Cleft Lip Repair The Importance of Identification and Utilization of Cupid Bow Peak on the Lateral Lip
Akihiko Oyama, Emi Funayama, Hiroshi Furukawa, Toshihiko Hayashi, Akira Saito, Yuhei Yamamoto
ANNALS OF PLASTIC SURGERY, 72, 1, 47, 49, Jan. 2014, [Peer-reviewed]
English, Scientific journal - Flap reconstruction in two patients with rare blood coagulation disorders
Toshihiko Hayashi, Akira Saito, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Yuhei Yamamoto
European Journal of Plastic Surgery, 37, 5, 297, 300, Springer Verlag, 2014, [Peer-reviewed]
English, Scientific journal - Skin necrosis around bilateral buttock of hikikomori teenager
Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Toshihiko Hayashi, Yuhei Yamamoto
International Journal of Culture and Mental Health, 7, 1, 43, 45, 2014, [Peer-reviewed]
English, Scientific journal - 遊離腓骨皮弁で再建した下顎骨粘液腫の1例
佐藤 千草, 坂本 泰輔, 蕨 雄大, 舟山 恵美, 山本 有平
日本形成外科学会会誌, 33, 11, 835, 840, (一社)日本形成外科学会, Nov. 2013
Japanese - Preliminary experience with intraoperative near-infrared fluorescence imaging in percutaneous sclerotherapy of soft-tissue venous malformations
Ishikawa, K., Sasaki, S., Furukawa, H., Nagao, M., Iwasaki, D., Saito, N., Yamamoto, Y.
Dermatologic Surgery, 39, 6, 907, 912, 01 Jun. 2013, [Peer-reviewed]
English, Scientific journal - Efficacy of percutaneous ethanol sclerotherapy for venous malformation in lower extremities: A retrospective review of 21 cases
Hiroshi Furukawa, Satoru Sasaki, Akihiko Oyama, Emi Funayama, Toshihiko Hayashi, Noriko Saito, Munetomo Nagao, William Mol, Yuhei Yamamoto
European Journal of Plastic Surgery, 36, 2, 105, 110, Feb. 2013, [Peer-reviewed]
English, Scientific journal - A New Aspect of Metastasis in Cutaneous Cancer Two Cases of Presacral Squamous Cell Carcinoma With Metastases to Internal Iliac Nodes
Kohei Oashi, Toshihiko Hayashi, Hiroshi Furukawa, Arata Tsutsumida, Chu Kimura, Hiroshi Oyamatsu, Akihiko Oyama, Emi Funayama, Akira Saito, Yuhei Yamamoto
ANNALS OF PLASTIC SURGERY, 70, 1, 79, 81, Jan. 2013, [Peer-reviewed]
English, Scientific journal - Pathophysiological characteristics of melanoma in-transit metastasis in a lymphedema mouse model
Kohei Oashi, Hiroshi Furukawa, Hiroshi Nishihara, Michitaka Ozaki, Akihiko Oyama, Emi Funayama, Toshihiko Hayashi, Yuji Kuge, Yuhei Yamamoto
Journal of Investigative Dermatology, 133, 2, 537, 544, Nature Publishing Group, 2013, [Peer-reviewed]
English, Scientific journal - 皮膚がんに特化した腋窩リンパ節郭清術についての検討
古川 洋志, 林 利彦, 大芦 孝平, 小山 明彦, 舟山 恵美, 山本 有平, 堤田 新, 齋藤 亮, 皆川 英彦, 吉田 哲憲
Skin Cancer, 27, 3, 274, 274, The Japanese Skin Cancer Society, 2013
Japanese - 皮膚がん治療における頸部郭清術の工夫
林 利彦, 古川 洋志, 大芦 孝平, 小山 明彦, 舟山 恵美, 山本 有平
Skin Cancer, 27, 3, 268, 268, The Japanese Skin Cancer Society, 2013
Japanese - ICGを併用したnavigation surgery－SLNBおよび腫瘍切除/所属リンパ節郭清に対する新たな取り組み－
林 利彦, 古川 洋志, 大芦 孝平, 小山 明彦, 舟山 恵美, 山本 有平
Skin Cancer, 27, 3, 294, 295, The Japanese Skin Cancer Society, 2013
Japanese - A New Model of Acquired Lymphedema in the Mouse Hind Limb A Preliminary Report
Kohei Oashi, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Toshihiko Hayashi, Akira Saito, Yuhei Yamamoto
ANNALS OF PLASTIC SURGERY, 69, 5, 565, 568, Nov. 2012, [Peer-reviewed]
English, Scientific journal - Effectiveness of combined pulsed dye and Q-switched ruby laser treatment for large to giant congenital melanocytic naevi
E. Funayama, S. Sasaki, H. Furukawa, T. Hayashi, T. Yamao, K. Takahashi, Y. Yamamoto, A. Oyama
BRITISH JOURNAL OF DERMATOLOGY, 167, 5, 1085, 1091, Nov. 2012, [Peer-reviewed]
English, Scientific journal - Microsurgical lymphaticovenous implantation targeting dermal lymphatic backflow using indocyanine green fluorescence lymphography in the treatment of postmastectomy lymphedema
古川, 洋志, 大澤, 昌之, 齋藤, 亮, 林, 利彦, 舟山, 恵美, 小山, 明彦, 関堂, 充, 山本, 有平
北海道醫學雜誌 = Acta medica Hokkaidonensia, 87, 6, 270, 270, Nov. 2012
Japanese, Scientific journal - Vascularised fat flaps lose 44% of their weight 24 weeks after transplantation
Kohei Oashi, Hiroshi Furukawa, Sadanori Akita, Masahiro Nakashima, Katsuya Matsuda, Akihiko Oyama, Emi Funayama, Toshihiko Hayashi, Akiyoshi Hirano, Yuhei Yamamoto
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 65, 10, 1403, 1409, Oct. 2012, [Peer-reviewed]
English, Scientific journal - Dominant lymph drainage in the facial region: evaluation of lymph nodes of facial melanoma patients
Toshihiko Hayashi, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Akira Saito, Yuhei Yamamoto
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 17, 4, 330, 335, Aug. 2012, [Peer-reviewed]
English, Scientific journal - A New Uniform Protocol of Combined Corticosteroid Injections and Ointment Application Reduces Recurrence Rates After Surgical Keloid/Hypertrophic Scar Excision
Toshihiko Hayashi, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Akira Saito, Naoki Murao, Yuhei Yamamoto
DERMATOLOGIC SURGERY, 38, 6, 893, 897, Jun. 2012, [Peer-reviewed]
English, Scientific journal - Direction of innervation after interpositional nerve graft between facial and hypoglossal nerves in individuals with or without facial palsy: A rat model for treating incomplete facial palsy
Ryuji Shichinohe, Hiroshi Furukawa, Mitsuru Sekido, Akira Saito, Toshihiko Hayashi, Emi Funayama, Akihiko Oyama, Yuhei Yamamoto
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 65, 6, 763, 770, Jun. 2012, [Peer-reviewed]
English, Scientific journal - Sentinel lymph node biopsy using real-time fluorescence navigation with indocyanine green in cutaneous head and neck/lip mucosa melanomas
Toshihiko Hayashi, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Akira Saito, Takeshi Yamao, Yuhei Yamamoto
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 34, 5, 758, 761, May 2012, [Peer-reviewed]
English, Scientific journal - Reconstruction of periorbital defects following malignant tumour excision: A report of 50 cases
Akira Saito, Noriko Saito, Hiroshi Furukawa, Toshihiko Hayashi, Akihiko Oyama, Emi Funayama, Hidehiko Minakawa, Yuhei Yamamoto
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 65, 5, 665, 670, May 2012, [Peer-reviewed]
English, Scientific journal - Effectiveness of muscle coverage to manage osteomyelitis of very late onset in the irradiated chest wall
Emi Funayama, Hidehiko Minakawa, Hidekazu Otani, Akihiko Oyama, Hiroshi Furukawa, Toshihiko Hayashi, Noriko Saito, Akira Saito, Yuhei Yamamoto
SURGERY TODAY, 42, 3, 306, 311, Feb. 2012, [Peer-reviewed]
English, Scientific journal - Statistical observation of malignant skin tumors at the Division of Plastic and Reconstructive Surgery, Hokkaido Cancer Center
SAITO Akira, MINAKAWA Hidehiko, SAITO Noriko, FUNAYAMA Emi, NOZAKI Ai, TAKAHASHI Yoriko, KATO Naoko
Skin Cancer, 27, 2, 137, 142, The Japanese Skin Cancer Society, 2012
Japanese, We reported a total of 300 cases (143 males and 157 females) with malignant skin tumors that were treated surgically at the Division of Plastic and Reconstructive Surgery, Hokkaido Cancer Center from 2001 to 2011. The most common malignant skin tumors were basal cell carcinoma (34%), followed by squamous cell carcinoma (24%). The most common tumor site was the head and neck region (64%), followed by the lower extremity (14%) and upper extremity (10%). The cases that were treated at our division have decreased gradually in recent years. Most of the patients (95%) were referred to our division from other departments or other facilities, and 83% of the patients were from the dermatology department at our hospital or other facilities.[Skin Cancer (Japan) 2012 ; 27 : 137-142] - INTRAOPERATIVE COLOR DOPPLER SONOGRAPHY IN THE ELEVATION OF ANTEROLATERAL THIGH FLAP
Akira Saito, Hiroshi Furukawa, Toshihiko Hayashi, Akihiko Oyama, Emi Funayama, Yuhei Yamamoto
MICROSURGERY, 31, 7, 582, 583, Oct. 2011, [Peer-reviewed]
English - The Importance of the Anti-aging Rejuvenation Clinic at Hokkaido University Hospital
FUNAYAMA Emi, YAMAMOTO Yuhei, OYAMA Akihiko, FURUKAWA Hiroshi, HAYASHI Toshihiko
日形会誌 : 日本形成外科学会会誌 = Journal of Japan Society of Plastic and Reconstructive Surgery, 31, 9, 619, 627, 20 Sep. 2011
Japanese - PRELIMINARY REPORT OF PREOPERATIVE ASSESSMENT OF ANTEROLATERAL THIGH FLAP PERFORATORS USING REAL-TIME VIRTUAL SONOGRAPHY SYSTEM
Akira Saito, Hiroshi Furukawa, Toshihiko Hayashi, Akihiko Oyama, Emi Funayama, Yuhei Yamamoto
MICROSURGERY, 31, 6, 499, 501, Sep. 2011, [Peer-reviewed]
English - Ethanol sclerotherapy with 'injection and aspiration technique' for giant lymphatic malformation in adult cases
Hiroshi Furukawa, Satoru Sasaki, Akihiko Oyama, Toshihiko Hayashi, Emi Funayama, Noriko Saito, Yuhei Yamamoto
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 64, 6, 809, 811, Jun. 2011, [Peer-reviewed]
English, Scientific journal - Microsurgical Lymphaticovenous Implantation Targeting Dermal Lymphatic Backflow Using Indocyanine Green Fluorescence Lymphography in the Treatment of Postmastectomy Lymphedema
Hiroshi Furukawa, Masayuki Osawa, Akira Saito, Toshihiko Hayashi, Emi Funayama, Akihiko Oyama, Mitsuru Sekido, Yuhei Yamamoto
PLASTIC AND RECONSTRUCTIVE SURGERY, 127, 5, 1804, 1811, May 2011, [Peer-reviewed]
English, Scientific journal - Our refinements in microtia reconstruction for the improvement of aesthetic outcome
小山 明彦, 古川 洋志, 舟山 恵美
Japanese journal of plastic surgery, 54, 3, 243, 250, 克誠堂出版, Mar. 2011
Japanese - How Do the Type and Location of a Vascular Malformation Influence Growth in Klippel-Trenaunay Syndrome?
Emi Funayama, Satoru Sasaki, Akihiko Oyama, Hiroshi Furukawa, Toshihiko Hayashi, Yuhei Yamamoto
PLASTIC AND RECONSTRUCTIVE SURGERY, 127, 1, 340, 346, Jan. 2011, [Peer-reviewed]
English, Scientific journal - A New Modified Technique for Removing Epidermal Cysts Using a Trepan in One Stage with a Smaller Postoperative Scar and No Recurrence
Emi Funayama, Akihiko Oyama, Hiroshi Furukawa, Toshihiko Hayashi, Mariko Sugino, Yuhei Yamamoto
DERMATOLOGIC SURGERY, 36, 12, 2050, 2052, Dec. 2010, [Peer-reviewed]
English, Scientific journal - 低蛋白血症が原因と推察された熱傷術後の創傷治癒遅延
蕨 雄大, 大野 健太郎, 池田 正起, 大芦 耕平, 七戸 龍司, 林 利彦, 舟山 恵美, 山本 有平
熱傷, 36, 2, 108, 109, (一社)日本熱傷学会, Jun. 2010
Japanese - Reconstructive considerations in the treetment of soft tissue sarcomas of the cheek.
Saito, N, Tsutsumida, A, Sekido, M, Furukawa, H, Oyama, A, Funayama, E, Saito, A, Yamamoto, Y
ACTA italica, 30, 103-106, Jan. 2010
English, Scientific journal - Laminin-421 produced by lymphatic endothelial cells induces chemotaxis for human melanoma cells
Noriko Saito, Jun-ichi Hamada, Hiroshi Furukawa, Arata Tsutsumida, Akihiko Oyama, Emi Funayama, Akira Saito, Tsutomu Tsuji, Mitsuhiro Tada, Tetsuya Moriuchi, Yuhei Yamamoto
PIGMENT CELL & MELANOMA RESEARCH, 22, 5, 601, 610, Oct. 2009, [Peer-reviewed]
English, Scientific journal - Correction of involutional entropion using a rhytidoplasty technique
Masatsugu Kondo, Hidehiko Minakawa, Emi Funayama, Toshihiko Hayashi
European Journal of Plastic Surgery, 32, 4, 181, 184, Aug. 2009, [Peer-reviewed]
English, Scientific journal - Sebaceous carcinoma of the eyelids: a review of 21 cases.
Saito A, Tsutsumida A, Furukawa H, Saito N, Yamamoto Y
Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 61, 1328, 1331, 11, Nov. 2008, [Peer-reviewed] - Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells.
Saito A, Saito N, Mol W, Furukawa H, Tsutsumida A, Oyama A, Sekido M, Sasaki S, Yamamoto Y
Melanoma research, 18, 85, 94, 2, Apr. 2008, [Peer-reviewed] - Intraoperative Simulation Device Using Negative Pressure for Construction of Framework in Microtia Reconstruction
Akihiko Oyama, Hideyuki Fujimori, Emi Funayama, Yuhei Yamamoto
PLASTIC AND RECONSTRUCTIVE SURGERY, 121, 3, 129E, 130E, Mar. 2008, [Peer-reviewed]
English - [Squamous cell carcinoma of the lower lip, completely responding to concurrent chemoradiotherapy with S-1].
Saito N, Tsutsumida A, Saito A, Furukawa H, Suzuki K, Nishioka T, Yamamoto Y
Gan to kagaku ryoho. Cancer & chemotherapy, 35, 495, 497, 3, Mar. 2008, [Peer-reviewed] - Salvage of cartilage framework exposure in microtia reconstruction using a mastoid fascial flap
Akihiko Oyama, Satoru Sasaki, Mol William, Emi Funayama, Yuhei Yamamoto
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 61, S110, S113, 2008, [Peer-reviewed]
English, Scientific journal - Forehead lipoma resection via a small remote incision using a surgical raspatory
Emi Funayama, Hidehiko Minakawa, Akihiko Oyama
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 56, 3, 458, 459, Mar. 2007, [Peer-reviewed]
English, Scientific journal - Velopharyngeal insufficiency in hemifacial microsomia: Analysis of correlated factors
Emi Funayama, Hiroharu H. Igawa, Noriko Nishizawa, Akihiko Oyama, Yuhei Yamamoto
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 136, 1, 33, 37, Jan. 2007, [Peer-reviewed]
English, Scientific journal - Melanoma of thumb: retrospective study for amputation levels, surgical margin and reconstruction.
Furukawa H, Tsutsumida A, Yamamoto Y, Sasaki S, Sekido M, Fujimori H, Sugihara T
Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 60, 1, 24, 31, 1, 2007, [Peer-reviewed] - Modification of thoracoscopy in pectus excavatum: insertion of both thoracoscope and introducer through a single incision to maximise visualisation.
Furukawa H, Sasaki S, William M, Sekido M, Tsutsumida A, Oyama A, Yamamoto Y
Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi, 41, 4, 189, 192, 4, 2007, [Peer-reviewed] - CD10が陽性を示したatypical fibroxanthomaの1例
氏家 英之, 加藤 直子, 夏賀 健, 冨田 幸希, 皆川 英彦, 舟山 恵美, 國分 一郎
臨床皮膚科, 60, 13, 1262, 1264, (株)医学書院, Dec. 2006
Japanese - リンパ節転移をきたした外陰部apocrine ductal carcinomaの1例
夏賀 健, 加藤 直子, 氏家 英之, 冨田 幸希, 皆川 英彦, 舟山 恵美, 木村 中
日本皮膚科学会雑誌, 116, 4, 478, 478, (公社)日本皮膚科学会, Apr. 2006
Japanese - 北海道がんセンターにおけるMerkel cell carcinoma 7例の検討
氏家 英之, 加藤 直子, 夏賀 健, 冨田 幸希, 皆川 英彦, 舟山 恵美
日本皮膚科学会雑誌, 116, 4, 486, 486, (公社)日本皮膚科学会, Apr. 2006
Japanese - Treatment strategy for cutaneous malignant melanoma.
Tsutsumida A, Furukawa H, Yamamoto Y, Sugihara T
International journal of clinical oncology, 10, 5, 311, 317, 5, Oct. 2005, [Peer-reviewed] - 二段階口蓋形成術法と一段階口蓋形成術法との比較検討 片側性完全唇顎口蓋裂児の5歳時までの歯槽弓形態変化
熊澤 龍一郎, 伊藤 裕美, 井上 農夫男, 川嶋 邦裕, 三古谷 忠, 松沢 祐介, 飯田 順一郎, 佐々木 了, 斉藤 豪紀, 松岡 真琴, 佐藤 嘉晃, 舟山 恵美, 山本 栄治, 戸塚 靖則, 杉原 平樹, 井川 浩晴
日本口蓋裂学会雑誌, 30, 2, 72, 72, (一社)日本口蓋裂学会, Apr. 2005
Japanese - Microvascularly augmented Occipito-Cervico-Dorsal flap (OCD flap)により再建した項部慢性膿皮症の1例
皆川 知広, 木村 中, 七戸 龍司, 舟山 恵美, 小山 明彦
日本形成外科学会会誌, 25, 3, 235, 235, (一社)日本形成外科学会, Mar. 2005
Japanese - Medial pedicled orbicularis oculi flapによる内眼角再建の経験
皆川 知広, 木村 中, 七戸 龍司, 舟山 恵美, 小山 明彦
道南医学会誌, 40, 98, 100, 道南医学会, Mar. 2005
Japanese - Apoptosis in keloids
Emi Funayama, Thinle Chodon, Akihiko Oyama, Tsuneki Sugihara
Japanese Journal of Plastic and Reconstructive Surgery, 47, 5, 493, 500, May 2004
Japanese, Scientific journal - 側頭筋膜弁で再建した耳後部有棘細胞癌の1例
木村 中, 舟山 恵美, 蔵盛 理保子, 古屋 和彦, 七戸 龍司, 皆川 知弘, 小山 明彦
道南医学会誌, 39, 196, 198, 道南医学会, Apr. 2004
Japanese - Change of weight-bearing pattern before and after plantar reconstruction with free anterolateral thigh flap.
Sekido M, Yamamoto Y, Furukawa H, Sugihara T
Microsurgery, 24, 4, 289, 292, 4, 2004, [Peer-reviewed] - Keratinocytes promote proliferation and inhibit apoptosis of the underlying fibroblasts: An important role in the pathogenesis of keloid
E Funayama, T Chodon, A Oyama, T Sugihara
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 121, 6, 1326, 1331, Dec. 2003, [Peer-reviewed]
English, Scientific journal - A case of angiosarcoma of the scalp treated by wide local excision
KIMURA Chu, FUNAYAMA Emi, FURUYA Kazuhiko, YOKOYAMA Tomoko, HAYASHI Toshihiko
Skin Cancer, 18, 1, 51, 55, The Japanese Skin Cancer Society, 30 May 2003
Japanese, Angiosarcoma of the scalp is a relatively rare malignant endothelial tumor. We experienced a case of angiosarcoma treated by wide local excision. An 85-year-old man was admitted to our hospital with a tumor which had appeared 1 month before on his left temporal region. The diagnosis of angiosarcoma was made based on the clinical features and histopathological finding of the lesions on the skin by a former institution. We performed wide local excision immediately circumferentially to a distance of more than 3-5cm from the tumor margin. At present, 13 months after surgery, no recurrence or metastasis has been observed. [Skin Cancer (Japan) 2003; 18: 51-55] - Bone Morphogenesis of the Piriform Aperture in Cleft Lip Patients Without Alveolar Cleft
KIMURA Chu, FUNAYAMA Emi, HAYASAKA Tokiko, MURAI Shigeru, YOKOYAMA Tomoko
Journal of Japanese Cleft Palate Association, 28, 1, 20, 27, Japanese Cleft Palate Association, 30 Apr. 2003
Japanese, There appear to be fewer abnormalities in the bony development of the upper jaw in patients who have cleft lip without cleft alveolar, hard or soft palate, and special care does not appear to be necessary. However, we have observed bone defects or bone deformity and asymmetry of the piriform aperture among patients undergoing long-term follow-up fa. r cleft lip without cleft hard or soft palate. There were six patients, two male and four female. Five patients had a right-sided cleft lip and one had a left-sided cleft lip. All patients were diagnosed as cleft lip, but no evidence of cleft palate was found. On three-dimensional CT scans taken at 5 to 17 years of age, deformity of the piriform aperture was observed. Auto logous bone grafting was performed in two of the patients and an artificial bone substitute was used in another two patients. Two patients did not undergo any treatment of the bony abnormality. In patient s who have unilateral cleft lip without cleft palate, we have found that good development of the external nose is often impossible even when the nasal cartilage has developed and the recess at the base of the ala nasae is repaired. However, when attention is also paid to the shape of the piriform aperture and deformity is found in the hard tissue that supports the nasal cartilage, it is important to improve its morphology by inserting autologous or artificial bone grafts. - [A study of interaction between keratinocytes and fibroblasts in keloid].
Funayama E
[Hokkaido igaku zasshi] The Hokkaido journal of medical science, 77, 6, 533, 541, Hokkaido University, Nov. 2002, [Peer-reviewed]
Japanese - Two innovations of the star flap technique for nipple reconstruction
YAMAMOTO Y.
Br. J. Plast. Surg., 54, 8, 723, 726, 2001 - Keloid-derived fibroblasts are refractory to Fas-mediated apoptosis and neutralization of autocrine transforming growth factor-beta 1 can abrogate this resistance
T Chodon, T Sugihara, HH Igawa, E Funayama, H Furukawa
AMERICAN JOURNAL OF PATHOLOGY, 157, 5, 1661, 1669, Nov. 2000, [Peer-reviewed]
English, Scientific journal - Multiple basal cell epithelioma. A case of multiple basal cell epithelioma after irradiation.
KIMURA Chu, MINAMIMOTO Toshiyuki, HAMADA Yoshimi, SASAKI Harue, FURUYA Kazuhiko, FUNAYAMA Emi
Skin Cancer, 13, 2, 158, 162, The Japanese Skin Cancer Society, 30 Oct. 1998
Japanese, Malignant skin tumors are known to develop in areas of chronic radiodermatitis. We experienced a patient with multiple basal cell carcinomas that developed about 50 years after irradiation. The patient was a 77-year-old man who underwent radiotherapy in his twenties for caries in the left shoulder joint. The dose given was unknown. Black skin tumor appeared initially about 10 years before the first consultation. The skin around the tumor began to erode about six months before presentation. Biopsy of the tumor was done at another institution and revealed basal cell carcinoma(BCC), so the patient was referred to our department. In addition to the BCC measuring 35×20mm in the left shoulder, BCC measuring 17×20mm and 15×15mm were found on the chest and the left axilla, respectively. The lesions were excised with a margin of 5mm from the radiodermatitis, and the resultant skin defects were covered with latissimus dorsi flaps. All three tumors were basal cell carcinomas. The patient died of an unrelated disease six years after surgery and there was no recurrence of his tumors.
Other Activities and Achievements
- New Design Concept of Nasolabial Flap for the Reconstruction of a Complex Defect in the Alar Base
Toshihiko Hayashi, Taku Maeda, Yuhei Yamamoto, Emi Funayama, Facial Plastic Surgery, 37, 1, 134, 135, 01 Feb. 2021
Thieme Medical Publishers, Inc., English, Report scientific journal - 上肢の電撃傷に対して遊離大網移植術を施行した1例
高橋 紀久子, 坂本 泰輔, 舟山 恵美, 蕨 雄大, 岩嵜 大輔, 佐藤 千草, 木村 中, 創傷, 9, 4, 126, 130, Oct. 2018
(一社)日本創傷外科学会, Japanese - 【顔面神経麻痺の治療アルゴリズム:ベストプラクティス】 当教室の顔面神経麻痺に対する外科治療のアルゴリズム
古川 洋志, 大澤 昌之, 小山 明彦, 村尾 尚規, 林 利彦, 舟山 恵美, 山本 有平, 日本頭蓋顎顔面外科学会誌, 34, 1, 16, 20, Apr. 2018
(一社)日本頭蓋顎顔面外科学会, Japanese - Horse‐related Facial Injuries at Our Institution: Report of 4 Cases
藤田宗純, 小山明彦, 大澤昌之, 村尾尚規, 林利彦, 舟山恵美, 山本有平, 日本頭蓋顎顔面外科学会誌, 33, 3, 87‐92, 25 Sep. 2017
Japanese - 片側唇顎口蓋裂に対する一期手術全51症例の経過(その1)
小山 明彦, 岡本 亨, 舟山 恵美, 佐藤 嘉晃, 西澤 典子, 今井 智子, 山本 有平, 日本口蓋裂学会雑誌, 42, 2, 93, 93, Apr. 2017
(一社)日本口蓋裂学会, Japanese - 片側唇顎口蓋裂に対する一期手術全51症例の経過(その2)
小山 明彦, 岡本 亨, 舟山 恵美, 佐藤 嘉晃, 西澤 典子, 今井 智子, 山本 有平, 日本口蓋裂学会雑誌, 42, 2, 94, 94, Apr. 2017
(一社)日本口蓋裂学会, Japanese - ケロイド・肥厚性瘢痕切除後の電子線照射とステロイド局注療法に関する考察 患者アンケート調査を通じて
池田 正起, 林 利彦, 村尾 尚規, 舟山 恵美, 小山 明彦, 山本 有平, 瘢痕・ケロイド治療ジャーナル, 10, 1, 6, Aug. 2016
(株)全日本病院出版会, Japanese - 自家培養表皮が効果的となりうる症例の選択 北海道大学病院における5年間の広範囲熱傷症例の検討
藤田 宗純, 村尾 尚規, 山尾 健, 七戸 龍司, 林 利彦, 舟山 恵美, 小山 明彦, 古川 洋志, 山本 有平, 熱傷, 42, 2, 64, 70, Jun. 2016
(一社)日本熱傷学会, Japanese - 当科における色素性母斑のレーザー治療
伊藤 梨里, 小山 明彦, 佐々木 了, 舟山 恵美, 古川 洋志, 林 利彦, 山本 有平, 日本レーザー医学会誌, 36, 4, 529, 529, Jan. 2016
(NPO)日本レーザー医学会, Japanese - 片側唇裂口蓋裂における口蓋形成術術式の違いによる言語成績の評価
舟山 恵美, 小山 明彦, 西澤 典子, 三古谷 忠, 今井 智子, 岡本 亨, 佐藤 嘉晃, 山本 有平, 日本頭蓋顎顔面外科学会誌, 31, 3, 218, 218, Oct. 2015
(一社)日本頭蓋顎顔面外科学会, Japanese - 成人まで観察し得たCarpenter症候群の1症例
伊藤 梨里, 小山 明彦, 舟山 恵美, 山本 有平, 日本頭蓋顎顔面外科学会誌, 31, 3, 247, 247, Oct. 2015
(一社)日本頭蓋顎顔面外科学会, Japanese - Marchac Frontal Modelを用いたCraniosynostosis頭蓋形成~その有用性とわれわれの工夫~
小山明彦, 古川洋志, 舟山恵美, 林利彦, 山本有平, 黒田敏, 中山若樹, 日本形成外科学会会誌, 34, 10, 780, 20 Oct. 2014
Japanese - 解剖学的サブユニットに最大限配慮した片側唇裂初回口唇形成術 (特集 口唇裂初回手術 : 最近の術式とその中期的結果) -- (片側口唇裂初回口唇形成術)
小山 明彦, 舟山 恵美, 山本 有平, Pepars, 89, 16, 22, May 2014
全日本病院出版会, Japanese - 常染色体22q11.2欠失症候群の経過分析
村尾 尚規, 小山 明彦, 舟山 恵美, 山本 有平, 西澤 典子, 福田 諭, 日本形成外科学会会誌, 34, 4, 312, 312, Apr. 2014
(一社)日本形成外科学会, Japanese - 特異な臨床像を呈したMadelung病(両側対称性脂肪腫症)の1例
伊藤 梨里, 舟山 恵美, 林 利彦, 古川 洋志, 小山 明彦, 山本 有平, 日本形成外科学会会誌, 34, 4, 311, 311, Apr. 2014
(一社)日本形成外科学会, Japanese - 片側唇顎口蓋裂に対する一期手術 全16例の短期経過
小山 明彦, 舟山 恵美, 古川 洋志, 林 利彦, 山本 有平, 岡本 亨, 西澤 典子, 今井 智子, 佐藤 嘉晃, 日本形成外科学会会誌, 33, 11, 865, 865, Nov. 2013
(一社)日本形成外科学会, Japanese - 術式の違いによる片側唇顎口蓋裂4歳時言語成績の検討
舟山 恵美, 小山 明彦, 山本 有平, 西澤 典子, 今井 智子, 三古谷 忠, 三上 愛, 佐々木 了, 岡本 亨, 日本形成外科学会会誌, 33, 11, 866, 866, Nov. 2013
(一社)日本形成外科学会, Japanese - Preliminary report of preoperative assessment of anterolateral thigh flap perforators using real-time virtual sonography system
齋藤 亮, 古川 洋志, 林 利彦, 小山 明彦, 舟山 恵美, 山本 有平, 北海道醫學雜誌 = Acta medica Hokkaidonensia, 87, 6, 264, 264, 01 Nov. 2012
Japanese - Hemifacial Microsomia における鼻咽腔閉鎖機能不全 : 関連因子の解析について
舟山 恵美, 日形会誌 : 日本形成外科学会会誌 = Journal of Japan Society of Plastic and Reconstructive Surgery, 32, 10, 775, 776, 20 Oct. 2012
Japanese - 片側唇顎口蓋裂に対する一期手術 全15例の短期経過
小山 明彦, 岡本 亨, 舟山 恵美, 佐藤 嘉晃, 西澤 典子, 今井 智子, 山本 有平, 日本口蓋裂学会雑誌, 37, 2, 111, 111, Apr. 2012
(一社)日本口蓋裂学会, Japanese - 口蓋形成術術式の違いによる言語成績の検討 片側唇顎口蓋裂4歳時の評価
舟山 恵美, 小山 明彦, 西澤 典子, 三古谷 忠, 今井 智子, 三上 愛, 佐々木 了, 日本口蓋裂学会雑誌, 37, 2, 133, 133, Apr. 2012
(一社)日本口蓋裂学会, Japanese - 口唇口蓋裂治療 未来へのネットワーク 理想的なチーム医療を目指して 北海道大学病院における口唇・口蓋裂チーム医療 歴史と現況
小山 明彦, 舟山 恵美, 佐藤 嘉晃, 上田 康夫, 三古谷 忠, 西澤 典子, 今井 智子, 岡本 亨, 山本 有平, 日本口蓋裂学会雑誌, 37, 2, 75, 75, Apr. 2012
(一社)日本口蓋裂学会, Japanese - Evaluation of Necrotizing Fasciitis, Using the LRINEC score & Probability Estimates for the Prediction of Mortality from Necrotizing Fasciitis
MAEDA Taku, FUNAYAMA Emi, YAMAMOTO Yuhei, 日形会誌 : 日本形成外科学会会誌 = Journal of Japan Society of Plastic and Reconstructive Surgery, 32, 2, 63, 68, 20 Feb. 2012
Japanese - Velopharyngeal Insufficiency in Hemifacial Microsomia
FUNAYAMA Emi, IGAWA Hiroharu H, NISHIZAWA Noriko, OYAMA Akihiko, YAMAMOTO Yuhei, 日形会誌 : 日本形成外科学会会誌 = Journal of Japan Society of Plastic and Reconstructive Surgery, 31, 11, 735, 740, 20 Nov. 2011
Japanese - 口蓋裂治療アップデート
小山 明彦, 舟山 恵美, 西澤 典子, 今井 智子, 佐藤 嘉晃, 岡本 亨, 山本 有平, 耳鼻咽喉科展望, 54, 5, 279, 286, Oct. 2011
耳鼻咽喉科展望会, Japanese - 口蓋裂二次手術としてのFurlow法 鼻腔ファイバースコープ所見に基づく適応判断
小山 明彦, 舟山 恵美, 古川 洋志, 林 利彦, 山本 有平, 西澤 典子, 日本形成外科学会会誌, 31, 5, 344, 344, May 2011
(一社)日本形成外科学会, Japanese - 口蓋裂二次手術としてのFurlow法 鼻腔ファイバースコープ所見に基づく適応判断について
小山 明彦, 西澤 典子, 佐々木 了, 舟山 恵美, 林 利彦, 大澤 昌之, 山本 有平, 日本頭蓋顎顔面外科学会誌, 26, 2, 143, 143, Jun. 2010
(一社)日本頭蓋顎顔面外科学会, Japanese - Treatment for senile blepharoptosis with skin resection: review of the width of excised skin by age bracket
近藤 雅嗣, 皆川 英彦, 舟山 恵美, Japanese journal of plastic surgery, 53, 1, 73, 78, Jan. 2010
克誠堂出版, Japanese - 頭蓋顔面骨切り術の術前計画と手術の実際 上下顎 上下顎骨切り術の術前計画と手術の実際 Desirable ProfileとDesirable Occlusionの両立のために
小山 明彦, 佐々木 了, 大澤 昌之, 上田 康夫, 佐藤 嘉晃, 舟山 恵美, 山本 有平, 日本頭蓋顎顔面外科学会誌, 25, 2, 88, 88, Jun. 2009
(一社)日本頭蓋顎顔面外科学会, Japanese - 北海道がんセンターにおける過去13年間の悪性黒色腫87例の検討
山根 尚子, 加藤 直子, 大澤 倫子, 柳 輝希, 皆川 英彦, 舟山 恵美, 夏賀 健, 日本皮膚科学会雑誌, 119, 1, 66, 66, Jan. 2009
(公社)日本皮膚科学会, Japanese - 北海道がんセンターにおける過去14年間の悪性黒色腫90例の検討
山根 尚子, 加藤 直子, 大澤 倫子, 柳 輝希, 伊藤 幹, 西村 真智子, 皆川 英彦, 舟山 恵美, 林 利彦, 夏賀 健, 日本皮膚科学会雑誌, 118, 10, 2024, 2024, Sep. 2008
(公社)日本皮膚科学会, Japanese - Our modification of operation technique for microform cleft lip
OYAMA Akihiko, 日本口蓋裂学会雑誌, 31, 2, 129, 129, 30 Apr. 2006
Japanese - 先天性両側鼻孔狭窄の1例
近藤 雅嗣, 皆川 英彦, 舟山 恵美, 山本 有平, 日形会誌 : 日本形成外科学会会誌 = Journal of Japan Society of Plastic and Reconstructive Surgery, 25, 10, 686, 689, 20 Oct. 2005
Japanese - Retrospective study on the risk factors for postoperative velopharyngeal insufficiency in nonsyndromic cleft palate
OYAMA Akihiko, 日本口蓋裂学会雑誌, 30, 2, 189, 189, 30 Apr. 2005
Japanese - われわれの工夫(16)唇裂外鼻変形に対する手術におけるわれわれの工夫
木村 中, 舟山 恵美, 蔵盛 理保子, 形成外科, 47, 3, 241, 243, Mar. 2004
克誠堂出版, Japanese - Evaluation of Basal Cell Carcinomas on the Nose
KIMURA Chu, FUNAYAMA Emi, HONMA Toyohiro, OYAMA Akihiko, KITAMURA Takashi, KOBAYASHI Tomoko, MURAO Naoki, 日本頭蓋顎顔面外科学会誌 = Journal of the Japan Society of Cranio-Maxillo-Facial Surgery, 19, 2, 117, 124, 25 Sep. 2003
Japanese - Reconstruction of the Burned Ear Deformity
KIMURA Chu, MINAMIMOTO Toshiyuki, HATA Shin-ya, SAITOH Akira, MINAKAWA Hidehiko, FUNAYAMA Emi, OYAMA Akihiko, 熱傷, 26, 3, 131, 139, 15 Sep. 2000
Japanese - 先天性鼻咽腔閉鎖機能不全を呈したHemifacial Microsomiaの1例
舟山 恵美, 井川 浩晴, 坂村 律生, 杉原 平樹, 畠 真也, 西澤 典子, 日本頭蓋顎顔面外科学会誌, 15, 1, 172, 172, Apr. 1999
(一社)日本頭蓋顎顔面外科学会, Japanese - Burned Hands Requiring Finger Amputation
KIMURA Chu, MINAMIMOTO Toshiyuki, KOKUBU Ichiroh, FUNAYAMA Emi, 熱傷, 25, 1, 28, 36, 15 Mar. 1999
Japanese - Two Cases of Burns after Epileptic Seizures while Bathing
KIMURA Chu, KITAMURA Takashi, KANAZAWA Hiroyuki, FUNAYAMA Emi, 熱傷, 24, 1, 30, 35, 15 Mar. 1998
Japanese - Treatment of Subungual Exostosis : Experiments with artificial dermis applied to nail bed defects
KIMURA Chu, KANAZAWA Hiroyuki, OYAMA Akihiko, FUNAYAMA Emi, 日本形成外科学会会誌, 16, 5, 332, 342, 31 May 1996
Japanese
Books and other publications
- 美容外科に必須の形成外科の基本知識と手技 （形成外科 増刊号 第58巻 2015年）
杠俊介, 野平久仁彦, 山脇孝徳, 三川信之, 渡辺頼勝, 山下昌信, 倉片優, 柏克彦, 上田和毅, 舟山恵美, 平林慎一, 川上重彦, 清川兼輔
克誠堂出版, 2015, [Joint work]
Research Themes
- 続発性リンパ浮腫における急性期重症化を防ぐ！レグネース１を標的とした新たな治療法
科学研究費助成事業
01 Apr. 2024 - 31 Mar. 2027
佐藤 千草, 舟山 恵美, 松田 識郁, 石川 耕資, 前田 拓
日本学術振興会, 基盤研究(C), 北海道大学, 24K12817 - Genetic diagnosis of vascular malformations by liquid biopsy and its application to precision medicine
Grants-in-Aid for Scientific Research
01 Apr. 2023 - 31 Mar. 2026
石川 耕資, 山本 有平, 舟山 恵美, 前田 拓
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 23K09072 - 低酸素応答システム活性化薬剤を用いた下肢慢性創傷の新治療
科学研究費助成事業
01 Apr. 2020 - 31 Mar. 2023
大澤 昌之, 舟山 恵美, 山本 有平, 前田 拓, 石川 耕資, 林 利彦
創傷治癒過程において酸素環境は重要である。生体は低酸素状態に対する適応応答としてHIF-1α (hypoxia inducible factor-1 alpha) を発現することで、血管新生などの創傷治癒の多段階で作用し、創傷治癒を促進するとされる。
本研究は、リンパ浮腫・虚血・糖尿病を念頭に置いたマウス下肢慢性創傷モデルを用いてHIF-1α調整薬剤の創傷治癒に与える影響を検証し、生体が本来もつ低酸素応答システムを利用した、新たな慢性創傷に対する治療法の開発を目的とした。
本年度は、２年目の計画に従い、初年度で行ったマウス後肢リンパ浮腫モデルを利用した創傷モデルの作成、Roxadustat（HIF-1α安定化薬）およびYC-１（HIF-1α阻害薬）の容量用法の検討に基づき、薬剤投与群と非投与群の間で創傷治癒期間および各タイムポイントでの創傷閉鎖割合に差があるかどうかを検討した。
作成した群は、①皮膚切開のみのコントロール（手術なし・薬剤非投与群）②リンパ浮腫モデル（薬剤非投与群）③リンパ浮腫モデル（Roxadustat投与群）④リンパ浮腫モデル（YC-1投与群）の4群であり、それぞれ大腿部に創傷を作成した。
皮膚切開のみのコントロール（手術なし・薬剤非投与群）に比してリンパ浮腫モデル（薬剤非投与群）は有意に創傷治癒期間が遅延した。また、通常のリンパ浮腫モデル（薬剤非投与群）に比して、Roxadustat（HIF-1α安定化薬）を使用した群で、創傷治癒期間の短縮および創閉鎖割合が促進し、YC-１（HIF-1α阻害薬）を使用した群で、創傷治癒期間の延長および創閉鎖割合が減少する傾向が見られた。また、薬剤を投与したリンパ浮腫モデル群間で後肢の周径の差および皮膚厚の差を認めた。これにより、リンパ浮腫の動態に対しても薬剤による影響がある可能性が示唆された。
日本学術振興会, 基盤研究(C), 北海道大学, 20K09841 - 低酸素応答システムからケロイド病態を斬る！～局所免疫の正常化と炎症・線維化の抑制
科学研究費助成事業
01 Apr. 2020 - 31 Mar. 2023
村尾 尚規, 山本 有平, 林 利彦, 舟山 恵美, 前田 拓, 石川 耕資
ケロイドは創傷治癒過程の異常により炎症と線維化が亢進した状態である。抗原とサイトカインの刺激を受けたCD4陽性T細胞、制御性T細胞とTh17細胞は相互に制御しバランスを保っており、炎症性疾患の発症や病態は制御性T細胞とTh17細胞のバランスにより影響される。われわれは既報でケロイド内では制御性T細胞の発現が低下し、免疫バランスの破綻により 炎症が遷延し線維化が亢進することを報告した。一方、近年ケロイド内は、低酸素状態であることがわかってきた。低酸素誘導因子(hypoxia-inducible factor、HIF)は、酸素供給が滞った組織内の細胞で活性化し 様々な遺伝子の発現を誘導し、生体の環境への適応を促す転写因子である。HIFは低酸素適応応答だけでなく、炎症や悪性腫瘍の病態にも関与する。HIFのサブタイプの中でも、ケロイド内ではHIF-1αの発現が亢進しており、低酸素状態を反映していると考えられる。HIF-1αはTh17細胞への分化を促進するが、制御性T細胞への分化を抑制し、免疫バランスを破綻させる。ケロイドにおいても持続的なHIF-1αの発現亢進が制御性T細胞とTh17細胞の免疫バランスを破綻させることで、ケロイド病態を悪化させている可能性があると仮定し、本研究を計画した。本年度は、文書による同意を得て、17例のケロイド患者からケロイド組織の採取を行い、そのうち15例から血液サンプルを採取することができた。採取した組織の部位別内訳は、耳垂7例、耳介6例、頚部1例、肩部1例、臍部2例であった。パラフィンブロック作成及び初代培養を行い、線維芽細胞を凍結保存した。また、採取した血液検体からLeucosep管を用いて末梢血単核球を分離し、凍結保存した。今後はこれらの検体を使用して共培養を行う予定である。
日本学術振興会, 基盤研究(C), 北海道大学, 20K09858 - Potential abilities of visceral fat:circulation and immunity (hyper 2-way player)
Grants-in-Aid for Scientific Research
01 Apr. 2019 - 31 Mar. 2022
Yamamoto Yuhei
Reconstruction using various materials has been reported as a method of physiologic surgical treatment of impairment of local lymphatic system. In this study, we focused on the omentum, which is considered to play a central role immunologically among visceral fat and verified it in an experimental animal model using mice.
We designed two models: a pedicled omentum transplantation model in which blood flow is maintained as a stemmed tissue valve, and a less invasive free omentum transplantation model, and compared and verified the contribution of each group to lymphatic reconstruction. The results suggest that both groups may promote lymphatic remodeling.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 19H03811 - 羊膜由来幹細胞の大いなる可能性～理想的な乳房再建を目指して
科学研究費補助金(基盤研究(C))
Apr. 2018 - Mar. 2021
舟山恵美
日本学術振興会, Principal investigator, Competitive research funding - 下肢慢性創傷の治癒促進に向けた低酸素応答システム制御の試み
科学研究費助成事業
01 Apr. 2017 - 31 Mar. 2020
七戸 龍司, 舟山 恵美, 山本 有平, 村尾 尚規
日本学術振興会, 基盤研究(C), 北海道大学, 17K11526 - 機能的リンパ組織移植法の開発!
科学研究費補助金(基盤研究(B))
Apr. 2016 - Mar. 2019
山本 有平
日本学術振興会, Competitive research funding - 郭清術後のリンパ組織再構築術～悪性黒色腫予後の改善を目指して！
科学研究費補助金(基盤研究(B))
Apr. 2015 - Mar. 2018
古川 洋志
日本学術振興会, Competitive research funding - ケロイドの免疫細胞治療を目指して！～制御性T細胞は炎症＆線維化を抑制する～
科学研究費補助金(基盤研究(B))
Apr. 2014 - Mar. 2017
村尾 尚規
日本学術振興会, Competitive research funding - リンパ浮腫を薬で治す！～DDS技術を駆使したVEGF-C徐放治療の開発
科学研究費補助金(基盤研究(C))
Apr. 2014 - Mar. 2017
小山 明彦
日本学術振興会, Competitive research funding - 筋肉内静脈網を利用したNeurotization～培養シュワン細胞の血管内遊走
科学研究費補助金(挑戦的萌芽研究)
Apr. 2014 - Mar. 2016
古川 洋志
日本学術振興会, Competitive research funding - 免疫抑制剤による新しいケロイド治療を目指して ～共培養モデルを用いた検討～
科学研究費補助金(挑戦的萌芽研究)
Apr. 2013 - Mar. 2016
山本有平
日本学術振興会, Competitive research funding - 悪性黒色腫における腫瘍免疫の破綻を解明する！～マウスリンパ浮腫モデルを用いて～
科学研究費補助金(基盤研究(B))
Apr. 2013 - Mar. 2016
山本 有平
学術振興会, Competitive research funding - Imaging of lymph flow in mouse model using in vivo imaging system
Grants-in-Aid for Scientific Research
01 Apr. 2012 - 31 Mar. 2015
HORIUCHI Katsumi, YAMAMOTO Yuhei, FURUKAWA Hiroshi, OYAMA Akihiko, FUNAYAMA Emi, HAYASHI Toshihiko, OSAWA Masayuki, SEKIDO Mitsuru
We analyzed the mechanism of the improvement of lymphedema using mouse hind limb model, with fluorescence lymphatic imaging using indocyanine green and in vivo imaging system as a fluorescence detector. To evaluate the improvement of lymphedema paw volume was measured using a water displacement plethysmometer,
We found a constant correlation between a degree of paw edema improvement and the reduction of the intensity of fluorescence.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 24592704 - 側側縫合によるNetwork型再建～神経信号付加の更なる効率化～
科学研究費補助金(挑戦的萌芽研究)
Apr. 2013 - Mar. 2015
大澤 昌之
日本学術振興会, Competitive research funding - Effects of estrogen and selective estrogen receptor modulators on normal and keloid fibroblasts
Grants-in-Aid for Scientific Research
01 Apr. 2012 - 31 Mar. 2014
FURUKAWA Hiroshi, YAMAMOTO Yuhei, OYAMA Akihiko, FUNAYAMA Emi, HAYASHI Toshiyuki, HORIUCHI Katsumi, SAITO Noriko
Selective estrogen receptor modulators (SERMs) bind to estrogen receptors acting as an agonist or an antagonist depending on the target tissue. First, we detected the expression of estrogen receptors in keloid fibroblasts. Second, we investigated the effects of SERMs on keloid fibroblasts. The effect is different depending on the concentration of SERMs. Some SERMs are suggested to inhibit cell proliferation of keloid fibroblasts.
Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 24659777 - Active axonal guidance for reconstruction of facial palsy
Grants-in-Aid for Scientific Research
01 Apr. 2012 - 31 Mar. 2014
SAITO Akira, YAMAMOTO Yuhei, HURUKAWA Hiroshi, OYAMA Akihiko, FUNAYAMA Emi, OSAWA Masayuki
In the basic experiment using nine-week-old wistar male rat, when the main trunk of the facial nerve was cut and anastomosed by epineural suture, the nerve regeneration already started from the sutured edge at four week past from the operation, and the nerve could reached to the mimetic muscles. Furthermore, when it was attached bFGF-impregnated MedGel on the point of epineural suture, the speed of nerve regeneration was faster than former group. And finally it also improve the movement of the mimetic muscles. This will enable us to expect a good role and capacity of the control released bFGF in the treatment of facial palsy after neurotmesis.
Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 24659776 - Mechanism of the improvement of lymphedema with the lymph node transfer
Grants-in-Aid for Scientific Research
01 Apr. 2012 - 31 Mar. 2014
SAITO Noriko, YAMAMOTO Yuhei, FURUKAWA Hiroshi, OYAMA Akihiko, FUNAYAMA Megumi, SAITO Akira
We developed the new lymph node transfer method using mouse hind limb model, in which we transferred the axillary lymph node to the popliteal space at the opposite side after the lymph node removal. Compared to control group, earlier improvement of lymphedema was observed in the lymph node transfer group.
We analyzed the mechanism of the improvement of lymphedema with the lymph node transfer, with fluorescence lymphatic imaging using indocyanine green and PDE system equipped with a charge-coupled device camera as a fluorescence detector. In the lymph node transfer group, formation of the collateral pathway and the transferred lymph node take were observed. This result supports the hypothesis that the lymph node transfer can improve lymphedema by increasing the lymphatic flow.
Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 24659775 - Lymph node targeting by human interferon-ß with hyaluronic acid based on metal coordination
Grants-in-Aid for Scientific Research
01 Apr. 2011 - 31 Mar. 2014
AKIRA Saito, YAMAMOTO Yuhei, FURUKAWA Hiroshi, OYAMA Akihiko, FUNAYAMA Emi, HAYASHI Toshihiko, TABATA Yasuhiko
The purpose of this study was to reduce the side effects and the pain caused by frequent injections of IFN-beta for melanoma while specifically targeting the lymph nodes by taking advantage of metal coordination to bind IFN-beta to hyaluronic acid. Sustained release of IFN-beta by conjugation with HA prolongs lymphatic retention. IFN-beta-hyaluronic acid conjugates can be given as an adjuvant therapy post-surgery to reduce the risk of recurrence and eradicate melanoma residuals, such as micrometastases. In addition, due to the sustained release characteristics of the conjugate, weekly injections for melanoma could replace conventional daily injections, thereby reducing pain as well as healthcare costs.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 23390406 - Controlled release of granulocyte colony-stimulating factor (G-CSF) enhances osteoconductive and biodegradable properties of beta-tricalcium phosphate (beta-TCP) in a rat calvarial defect model
Grants-in-Aid for Scientific Research
2011 - 2013
OYAMA Akihiko, YAMAMOTO Yuhei, FURUKAWA Hiroshi, FUNAYAMA Emi, HAYASHI Toshikhiko, SAITO Akira, TABATA Yasuhiko
A total of 27 calvarial defects were randomly divided into nine treatment groups. One set of defects was filled with a beta-TCP disc containing normal saline alone (group-A, control) or 1 (group-B), 5 (group-C), or 20 ug of G-CSF saline solution (group-D). Another set of defects was filled with a beta-TCP disc with an overlaid gelatin hydrogel sheet incorporating normal saline alone (group-E), or 1 (group-F), 5 (group-G), or 20 ug of G-CSF solution (group-H). The last set of defects was left untreated (group-I). Histologic and histomorphometric analyses were performed at eight weeks postoperatively.
In groups F and G, values of newly formed bone were significantly higher compared to group A. The percentage of remaining beta-TCP in group G was significantly lower compared to group A.
Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 23659826 - A New Perspective Of Therapies For Keloids: Application Of An Antifibrotic Medicine
Grants-in-Aid for Scientific Research
2011 - 2013
HAYASHI TOSHIHIKO, YAMAMOTO Yuhei, FURUKAWA Hiroshi, OYAMA Akihiko, FUNAYAMA Emi, SAITO Akira, MURAO Naoki
Pirfenidone is a novel anti-fibrotic agent used in the treatment of idiopathic pulmonary fibrosis. Keloid is a cutaneous fibrotic disease characterized by fibroblast overproliferation and fibrogenesis such as the abnormally high production of alpha smooth muscle actin and collagen in keloid-derived fibroblasts. The effects of pirfenidone on cell proliferation, type I collagen production, and alpha-smooth muscle actin expression in keloid-derived fibroblasts were investigated in this study.
Results showed that pirfenidone significantly inhibited cell proliferation, type I collagen production, and alpha-smooth muscle actin expression in keloid-derived fibroblasts. Our study highlights the potential use of pirfenidone in the treatment of keloids.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 23592637 - Does HGF act as a inhibitor of TGF-β mediated keloid formation?
Grants-in-Aid for Scientific Research
2011 - 2012
YAMAMOTO Yuhei, FURUKAWA Hiroshi, OYAMA Akihiko, FUNAYAMA Emi, HAYASHI Toshihiko, SAITO Akira
HGF (hepatocyte growth factor) and TGF-β(transforming growth factor-β) often act antagonistically each other. For example, TGF-β accelerates liver fibrosis, whereas HGF prevents its progression. In our study, HGF suppressed type I collagen mRNA expression in keloid fibroblasts. HGF is suggested to repress TGF-β signal transduction pathway.
Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 23659825 - The role of circulating fibrocytes in keloid diathesis.
Grants-in-Aid for Scientific Research
2010 - 2012
FUNAYAMA Emi, YAMAMOTO Yuhei, OYAMA Akihiko, FURUKAWA Hiroshi, HAYASHI Toshihiko
Identification of chemokine (CXCL12) in human keloid tissue using immunohistochemistry(2) Development of a mouse dermal inflammation model using PMA(3) Isolation of human fibrocyte and transfer of human fibrocytes to mice
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Principal investigator, Competitive research funding, 22591988 - Clarifying the metastatic mechanisms of melanoma by imaging techniques
Grants-in-Aid for Scientific Research
2010 - 2012
FURUKAWA Hiroshi, YAMAMOTO Yuhei, OYAMA Akihiko, FUNAYAMA Emi, HAYASHI Toshihiko, SAITO Akira, OZAKI Michitaka, TSUTSUMIDA Arata, KUGE Yuji, OASHI Kohei
We reproduced melanoma in-transit metastasis (ITM) in a mouse hind limb by transplanting melanoma cells into the footpad of a mouse with lymphedema (LE). The tumor cells at the ITM site were highly proliferative, and mice with ITMs were more likely than control mice to develop distant lymph node and lung metastases. Peritumoral lymphatic vessels and tumor-associated blood vessels were increased in the primary tumor site of the LE mice.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, Coinvestigator not use grants, Competitive research funding, 22390330 - Dynamic change of Myogenin in denervated rat mimetic muscle: Does the neural repair repress its expression ?
Grants-in-Aid for Scientific Research
2010 - 2012
YAMAMOTO Yuhei, SEKIDOU Mitsuru, HATOU Naoto, FURUKAWA Hiroshi, OYAMA Akihiro
Myogenin expression in facial mimetic muscles would be accumulated by denervation rapidly, and repressed by nerve repair. Myog expression level of mimetic muscle, just after nerve repair, will help surgeon to predict thepost-operative prognosis for facial palsy.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, Coinvestigator not use grants, Competitive research funding, 22390331 - Can we detect the invasive keloid fibroblasts for the effective treatment?
Grants-in-Aid for Scientific Research(基盤研究(B))
2008 - 2010
佐々木 了, Toshihiko HAYASHI, 関堂 充, 林 利彦, Yuhei YAMAMOTO, Hiroshi FURUKAWA, Akihiko OYAMA, Emi FUNAYAMA, Mitsuru SEKIDO, Arata TSUTSUMIDA, Akira SAITO
In a keloid lesion, T lymphocytes are found around activated and invasive keloid fibroblasts whose levels of type 1 collagen production, transforming growth factor-beta expression and α-SMA expression are very high. So we co-cultured keloid fibroblasts with T lymphocytes to establish the keloid in vitro model. But the levels of type 1 collagen and transforming growth factor-beta of the keloid fibroblasts co-cultured with T lymphocytes tended to rather decrease. Some subset of T lymphocytes might suppress keloid fibroblasts.
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 北海道大学, Coinvestigator not use grants, Competitive research funding, 20390454 - The influence of interactions between normal lymphatic endothelial cells and melanoma cells on cell migration
Grants-in-Aid for Scientific Research(基盤研究(B))
2008 - 2010
堤田 新, Akihiko OYAMA, 齋藤 亮, 浜田 淳一, Yuhei YAMAMOTO, Hiroshi FURUKAWA, Emi FUNAYAMA, Toshihiko HAYASHI, Akira SAITO
Laminin-421 secreted by LEC possibly facilitates lymphatic metastasis through the induction of chemotaxis of melanoma cells.
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 北海道大学, Coinvestigator not use grants, Competitive research funding, 20390455 - New lymphatic imaging with indocyanine green (ICG) dye labeled hyaluronic acid derivative
Grants-in-Aid for Scientific Research(基盤研究(B))
2007 - 2009
Hiroshi FURUKAWA, 関堂 充, 田畑 泰彦, 久下 裕司, Yuhei YAMAMOTO, 堤田 新, Emi FUNAYAMA, Toshihiko HAYASHI, Akihiko OYAMA, Yasuhiko TABATA
In this study, we succeeded in invention of new lymphatic imaging complex, consists of hyaluronicacid derivative labeled by indocyanine green (ICG) dye, which is clinically used in neae-infraredbioimaging, such as sentinel lymph node biopsy.Investigations into physical characteristics and in vivo kinetics of this complex have revealed that ICG fluorescence was enhanced and sustained enough for clinically use due to formation of the complex, and it is likely that the complex has more tendency to be transported to lymphatics.
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 北海道大学, Coinvestigator not use grants, Competitive research funding, 19390450
