Mar. 2018, Japan Society for Bioscience, Biotechnology, and Agrochemistry, The Japan Bioscience, Biotechnology and Agrochemistry Society Award for the Encouragement of Young Scientists　　　　　　　　　　　　　　　
食用植物の抗肥満、抗糖尿病効果を分子レベルで理解するための生物活性成分の探索と機能解析
KATO, Eisuke

Functional evaluation of TIE2 activators identified in a model system using human umbilical vein endothelial cells
Saki Igarashi, Koki Ishigami, Naonori Uchida, Eisuke Kato
Bioorganic & Medicinal Chemistry Letters, 127, 130311, Elsevier BV, Nov. 2025, [Peer-reviewed], [Corresponding author]
English, Scientific journal

Bioactive Components in Black Currant Fruit, Red Perilla (Shiso) Leaf, and Chinese Sweet Tea That Enhance Testosterone Production in Leydig Cells and Their Combined Effect in Male Mice
Eisuke Kato, Yosuke Inagaki, Hiromi Kayooka, Yusuke Adachi, Tomoaki Nagase, Naofumi Terada, Ai Tsuruma
ACS Food Science & Technology, 4, 5, 1209, 1215, 17 May 2024, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal, 44515277

Flavan-3-ols, flavonoids, anthocyanidins and triterpenoids induces TIE2 phosphorylation -a candidate target for the vascular protective effects
Saki Igarashi, Sayaka Hioki, Naoto Sakamaru, Asahi Suzuki, Mihoko Kurokawa, Eisuke Kato
Natural Product Research, 39, 12, 3481, 3485, Informa UK Limited, 12 Apr. 2024, [Peer-reviewed], [Corresponding author]
English, Scientific journal

α-Tocotrienol in rice bran enhances steroidogenesis in mouse Leydig cell via increased gene expression of steroidogenic acute regulatory protein and induction of its mitochondrial translocation
Naofumi Terada, Tomoaki Nagase, Hiromi Kayooka, Yusuke Adachi, Eisuke Kato
Bioscience, Biotechnology, and Biochemistry, 88, 2, 189, 195, 24 Jan. 2024, [Peer-reviewed], [Corresponding author]
English, Scientific journal, 14202882

Association of Bitter Taste Receptors with Obesity and Diabetes and Their Role in Related Tissues
Eisuke Kato, Shota Oshima
Receptors, 05 Dec. 2023, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Murine fecal microRNAs alter the composition of cultured gut microbiota
Fumina Ohsaka, Mayuko Yamaguchi, Yuka Teshigahara, Moeka Yasui, Eisuke Kato, Kei Sonoyama
Biochemical and Biophysical Research Communications, 685, 149184, 149184, Elsevier BV, Dec. 2023
Scientific journal

Taste 2 Receptor Is Involved in Differentiation of 3T3-L1 Preadipocytes
Shunsuke Kimura, Ai Tsuruma, Eisuke Kato
International Journal of Molecular Sciences, 23, 15, 8120, 8120, MDPI AG, 23 Jul. 2022, [Peer-reviewed], [Corresponding author]
English, Scientific journal, Expression of taste 2 receptor (T2R) genes, also known as bitter taste receptor genes, has been reported in a variety of tissues. The white adipose tissue of mice has been shown to express Tas2r108, Tas2r126, Tas2r135, Tas2r137, and Tas2r143, but the function of T2Rs in adipocytes remains unclear. Here, we show that fasting and stimulation by bitter compounds both increased Tas2r expression in mouse white adipose tissue, and serum starvation and stimulation by bitter compounds both increased the expression of Tas2r genes in 3T3-L1 adipocytes, suggesting that T2Rs have functional roles in adipocytes. RNA sequencing analysis of 3T3-L1 adipocytes stimulated by epicatechin, the ligand of Tas2r126, suggested that this receptor may play a role in the differentiation of adipocytes. Overexpression of Tas2r126 in 3T3-L1 preadipocytes decreases fat accumulation after induction of differentiation and reduces the expression of adipogenic genes. Together, these results indicate that Tas2r126 may be involved in adipocyte differentiation.

Saponins are responsible for the anti-obesogenic activity of Acacia concinna
Zhao Zhuoyue, Wijitrapha Ruangaram, Eisuke Kato
Journal of Natural Medicines, 75, 4, 1005, 1013, Springer Science and Business Media {LLC}, 21 Sep. 2021, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
English, Scientific journal

Proteinous pancreatic lipase inhibitor is responsible for the antiobesity effect of young barley (Hordeum vulgare L.) leaf extract
Eisuke Kato, Ai Tsuruma, Ayaka Amishima, Hiroshi Satoh
Bioscience, Biotechnology, and Biochemistry, 85, 8, 1885, 1889, Oxford University Press ({OUP}), 23 Jul. 2021, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal,
Young barley leaves (Hordeum vulgare L.) have various health effects and are employed as an ingredient in the production of health-promoting foods. Promoting antiobesity is one such health effect; however, the mechanism and bioactive compounds are unclear. In this research, young barley leaf extract (YB) was demonstrated to possess pancreatic lipase inhibitory activity. The addition of YB to a high-fat diet in mice increased fecal lipid content, indicating reduced absorption of lipids as the mechanism underlying antiobesity effect. The investigation of bioactive compounds in YB resulted in the identification of fructose–bisphosphate aldolase as a proteinous lipase inhibitor. Maximum inhibition of the protein was 45%, but inhibition was displayed at a concentration as low as 16 ng/mL, which is a characteristic inhibition compared with other reported proteinous lipase inhibitors.

Post-harvest and Extraction Conditions for the Optimum Alpha Glucosidase Inhibitory Activity of Stenochlaena palustris
Maria Dewi P. Tirtaningtyas Gunawan-Puteri, Eisuke Kato, Della Rahmawati, Stevan Teji, Jevon Ardy Santoso, Febbyandi Isnanda Pandiangan, Yanetri Asi Nion
International Journal of Technology, 12, 3, 649, 649, International Journal of Technology, 19 Jul. 2021, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
English, Scientific journal

TAS2R expression profile in brown adipose, white adipose, skeletal muscle, small intestine, liver and common cell lines derived from mice
Eisuke Kato
Gene Reports, 20, 100763, 100763, Sep. 2020, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
English, Scientific journal, 14202880

Selection of Thai Medicinal Plants with Anti-Obesogenic Potential via In Vitro Methods
Wijitrapha Ruangaram, Eisuke Kato
Pharmaceuticals, 13, 4, 56, 56, 29 Mar. 2020, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
English, Scientific journal

Silychristin derivatives conjugated with coniferylalcohols from silymarin and their pancreatic α-amylase inhibitory activity
Eisuke Kato, Natsuka Kushibiki, Hiroshi Satoh, Jun Kawabata
Natural Product Research, 34, 6, 759, 765, Informa UK Limited, 18 Mar. 2020, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
English, Scientific journal

Quassinoids in Brucea javanica are potent stimulators of lipolysis in adipocytes
Lucy Lahrita, Kenta Moriai, Ryohei Iwata, Kazuki Itoh, Eisuke Kato
Fitoterapia, 137, 104250, 104250, Elsevier BV, Sep. 2019, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
English, Scientific journal

Bioactive compounds in plant materials for the prevention of diabetesand obesity
Eisuke Kato
Bioscience, Biotechnology, and Biochemistry, 83, 6, 975, 985, Informa {UK} Limited, 03 Jun. 2019, [Peer-reviewed], [Invited], [Lead author, Corresponding author], [International Magazine]
English, Scientific journal,
Plant materials have been widely studied for their preventive and therapeutic effects for type 2 diabetes mellitus (T2DM) and obesity. The effect of a plant material arises from its constituents, and the study of these bioactive compounds is important to achieve a deeper understanding of its effect at the molecular level. In particular, the study of the effects of such bioactive compounds on various biological processes, from digestion to cellular responses, is required to fully understand the overall effects of plant materials in these health contexts. In this review, I summarize the bioactive compounds we have recently studied in our research group that target digestive enzymes, dipeptidyl peptidase-4, myocyte glucose uptake, and lipid accumulation in adipocytes.


Abbreviations: AC: adenylyl cyclase; AMPK: AMP-activated protein kinase; βAR: β-adrenergic receptor; CA: catecholamine; cAMP: cyclic adenosine monophosphate; cGMP: cyclic guanosine monophosphate; DPP-4: dipeptidyl peptidase-4; ERK: extracellular signal-regulated kinase; GC: guanylyl cyclase; GH: growth hormone; GLP-1: glucagon-like peptide-1; GLUT: glucose transporter; HSL: hormone-sensitive lipase; IR: insulin receptor; IRS: insulin receptor substrate; MAPK: mitogen-activated protein kinase; MEK: MAPK/ERK kinase; MG: maltase-glucoamylase; NP: natriuretic peptide; NPR: natriuretic peptide receptor; mTORC2: mechanistic target of rapamycin complex-2; PC: proanthocyanidin; PI3K: phosphoinositide 3-kinase; PKA: cAMP-dependent protein kinase; PKB (AKT): protein kinase B; PKG: cGMP-dependent protein kinase; PPARγ: peroxisome proliferator-activated receptor-γ; SGLT1: sodium-dependent glucose transporter 1; SI: sucrase-isomaltase; T2DM: type 2 diabetes mellitus; TNFα: tumor necrosis factor-α.

Macrocarpal C isolated from Eucalyptus globulus inhibits dipeptidyl peptidase 4 in an aggregated form
Eisuke Kato, Kazuhiro Kawakami, Jun Kawabata
Journal of Enzyme Inhibition and Medicinal Chemistry, 33, 1, 106, 109, 01 Jan. 2018, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
English, Scientific journal

Ability of higenamine and related compounds to enhance glucose uptake in L6 cells
Eisuke Kato, Shunsuke Kimura, Jun Kawabata
BIOORGANIC & MEDICINAL CHEMISTRY, 25, 24, 6412, 6416, Dec. 2017, [Peer-reviewed]
English, Scientific journal

Synthesis and Detailed Examination of Spectral Properties of (S)- and (R)-Higenamine 4 '-O-beta-D-Glucoside and HPLC Analytical Conditions to Distinguish the Diastereomers
Eisuke Kato, Ryohei Iwata, Jun Kawabata
MOLECULES, 22, 9, 1450, Sep. 2017, [Peer-reviewed]
English, Scientific journal

Isolation and lipolytic activity of eurycomanone and its epoxy derivative from Eurycoma longifolia
Lucy Lahrita, Ryota Hirosawa, Eisuke Kato, Jun Kawabata
BIOORGANIC & MEDICINAL CHEMISTRY, 25, 17, 4829, 4834, Sep. 2017, [Peer-reviewed]
English, Scientific journal

Intestinal alpha-Glucosidase Inhibitors in Achillea millefolium
Kota Noda, Eisuke Kato, Jun Kawabata
NATURAL PRODUCT COMMUNICATIONS, 12, 8, 1259, 1261, Aug. 2017, [Peer-reviewed]
English, Scientific journal

Astilbe thunbergii reduces postprandial hyperglycemia in a type 2 diabetes rat model via pancreatic alpha-amylase inhibition by highly condensed procyanidins
Eisuke Kato, Natsuka Kushibiki, Yosuke Inagaki, Mihoko Kurokawa, Jun Kawabata
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 81, 9, 1699, 1705, 2017, [Peer-reviewed]
English, Scientific journal

Synthesis and study of the pancreatic alpha-amylase inhibitory activity of methyl acarviosin and its derivatives
Eisuke Kato, Fumiaki Chikahisa, Jun Kawabata
TETRAHEDRON LETTERS, 57, 12, 1365, 1367, Mar. 2016, [Peer-reviewed]
English, Scientific journal

Isolation of rugosin A, B and related compounds as dipeptidyl peptidase-IV inhibitors from rose bud extract powder
Eisuke Kato, Yuta Uenishi, Yosuke Inagaki, Mihoko Kurokawa, Jun Kawabata
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 80, 11, 2087, 2092, 2016, [Peer-reviewed]
English, Scientific journal

Higenamine 4 '-O-beta-D-glucoside in the lotus plumule induces glucose uptake of L6 cells through beta 2-adrenergic receptor
Eisuke Kato, Yosuke Inagaki, Jun Kawabata
BIOORGANIC & MEDICINAL CHEMISTRY, 23, 13, 3317, 3321, Jul. 2015, [Peer-reviewed]
English, Scientific journal

Uncovering potential of Indonesian medicinal plants on glucose uptake enhancement and lipid suppression in 3T3-L1 adipocytes
Lucy Lahrita, Eisuke Kato, Jun Kawabata
JOURNAL OF ETHNOPHARMACOLOGY, 168, 229, 236, Jun. 2015, [Peer-reviewed]
English, Scientific journal

Selective purification of intestinal maltase complex by affinity chromatography employing an uncompetitive inhibitor as the ligand
Eisuke Kato, Hiroki Tsuji, Jun Kawabata
TETRAHEDRON, 71, 9, 1419, 1424, Mar. 2015, [Peer-reviewed]
English, Scientific journal

alpha-Amylase Inhibitory Triterpene from Abrus precatorius Leaves
Ryuta Yonemoto, Miyuki Shimada, Maria D. P. T. Gunawan-Puteri, Eisuke Kato, Jun Kawabata
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62, 33, 8411, 8414, Aug. 2014, [Peer-reviewed]
English, Scientific journal

Hydroxylamine enhances glucose uptake in C2C12 skeletal muscle cells through the activation of insulin receptor substrate 1
Taro Kimura, Eisuke Kato, Tsukasa Machikawa, Shunsuke Kimura, Shinji Katayama, Jun Kawabata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 445, 1, 6, 9, Feb. 2014, [Peer-reviewed]
English, Scientific journal

Identification of alpha-glucosidase inhibitors from the leaves of Pluchea indica (L.) Less., a traditional Indonesian herb: promotion of natural product use
Ines Septi Arsiningtyas, Maria D. P. T. Gunawan-Puteri, Eisuke Kato, Jun Kawabata
NATURAL PRODUCT RESEARCH, 28, 17, 1350, 1353, 2014, [Peer-reviewed]
English, Scientific journal

Identification of hydroxychavicol and its dimers, the lipase inhibitors contained in the Indonesian spice, Eugenia polyantha
Eisuke Kato, Ryo Nakagomi, Maria D. P. T. Gunawan-Puteri, Jun Kawabata
FOOD CHEMISTRY, 136, 3-4, 1239, 1242, Feb. 2013, [Peer-reviewed]
English, Scientific journal

Substrate-like water soluble lipase inhibitors from Filipendula kamtschatica
Eisuke Kato, Michitsugu Yama, Ryo Nakagomi, Toshiro Shibata, Keizo Hosokawa, Jun Kawabata
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22, 20, 6410, 6412, Oct. 2012, [Peer-reviewed]
English, Scientific journal

Synthesis and the Intestinal Glucosidase Inhibitory Activity of 2-Aminoresorcinol Derivatives toward an Investigation of Its Binding Site
Eisuke Kato, Kenichi Oikawa, Keisuke Takahashi, Jun Kawabata
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 76, 5, 1044, 1046, May 2012, [Peer-reviewed]
English, Scientific journal

Screening and Identification of Disaccharides with Insulin Mimetic Activity against L6 Cells
Kazuaki Yamasaki, Ryogo Hishiki, Eisuke Kato, Jun Kawabata
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 76, 4, 841, 842, Apr. 2012, [Peer-reviewed]
English, Scientific journal

alpha-Amylase inhibitors from an Indonesian medicinal herb, Phyllanthus urinaria
Maria D. P. T. Gunawan-Puteri, Eisuke Kato, Jun Kawabata
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 92, 3, 606, 609, Feb. 2012, [Peer-reviewed]
English, Scientific journal

Synthesis and alpha-amylase inhibitory activity of glucose-deoxynojirimycin conjugates
Eisuke Kato, Naoya Iwano, Akihiko Yamada, Jun Kawabata
TETRAHEDRON, 67, 40, 7692, 7702, Oct. 2011, [Peer-reviewed]
English, Scientific journal

Study of Kaempferol Glycoside as an Insulin Mimic Reveals Glycon To Be the Key Active Structure
Kazuaki Yamasaki, Ryogo Hishiki, Eisuke Kato, Jun Kawabata
ACS MEDICINAL CHEMISTRY LETTERS, 2, 1, 17, 21, Jan. 2011, [Peer-reviewed]
English, Scientific journal

Study on Insulin-Mimetic Activity of Kaempferol 3-Ο-neohesperidoside
Yamasaki Kazuaki, Hishiki Ryogo, Kato Eisuke, Kawabata Jun
Symposium on the Chemistry of Natural Products, symposium papers, 52, 409, 414, Symposium on the chemistry of natural products, 01 Sep. 2010
Japanese, Diabetes mellitus (DM) is a currently arising disease with patients increasing throughout the world. Treaments of diabetes mellitus focus on control of blood glucose level. In late years, some of flavonoid glycosides are reported as an insulin-mimetic compound which regulates glucose uptake ability of insulin-sensitive cells (insulin-mimetic activity). These compounds are thought to be effective for the treatment of DM by replacing insulin or supporting currently used medicines. One of these insulin-mimetic flavonoid glycosides, kaempferol 3-O-neohesperidoside (1), was idolated from a stem of Cyathea phalerata Mart., and reported to show strong insulin-mimetic activity at nanomolar level. We focused on this attractive compound, and started to perform a structure-activity relationship study on the insulin-mimetic effect of 1 by a synthetic method and in vitro assay emloying cultured cells. We achieved a synthesis of 1 for the first time, and performed insluin-mimetic activity examination of synthetic 1 against muscular cell model. L6 cells. As a result, a significantly high activity was observed in synthetic 1 at 1 nM. Further study on structure-activity relationship using several synthetic derivatives with partial structure of 1 revealed that neohesperidose (19) to be the major contributing structure for this activity. These findings may lead to utilization of disacchrides for treatment for diabetes mellitus.

Search for alpha-glucosidase and alpha-amylase inhibitors from Indonesian medicinal plants
M. Gunawan-Puteri, E. Kato, J. Kawabata
PLANTA MEDICA, 76, 12, 1182, 1182, Aug. 2010, [Peer-reviewed]
English

Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds
Eisuke Kato, Jun Kawabata
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20, 15, 4333, 4336, Aug. 2010, [Peer-reviewed]
English, Scientific journal

Methyl Caffeate as an alpha-Glucosidase Inhibitor from Solanum torvum Fruits and the Activity of Related Compounds
Keisuke Takahashi, Yasuyuki Yoshioka, Eisuke Kato, Shigeki Katsuki, Osamu Iida, Keizo Hosokawa, Jun Kawabata
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 74, 4, 741, 745, Apr. 2010, [Peer-reviewed]
English, Scientific journal

Affinity purification and characterization of a key enzyme responsible for circadian rhythmic control of nyctinasty in Lespedeza cuneata L.
Eisuke Kato, Takehiko Sasaki, Minoru Ueda
BIOORGANIC & MEDICINAL CHEMISTRY, 16, 8, 4600, 4616, Apr. 2008, [Peer-reviewed]
English, Scientific journal

Affinity purification of the key enzyme of nyctinasty controlling the rhythm of leaf movement using gluconamidine ligand
Eisuke Kato, Takehiko Sasaki, Tadahiro Kumagai, Minoru Ueda
TETRAHEDRON LETTERS, 48, 13, 2409, 2413, Mar. 2007, [Peer-reviewed]
English, Scientific journal

Synthesis of novel ginkgolide photoaffinity-biotin probes
Eisuke Kato, Rachel Howitt, Sergei V. Dzyuba, Koji Nakanishi
ORGANIC & BIOMOLECULAR CHEMISTRY, 5, 23, 3758, 3761, 2007, [Peer-reviewed]
English, Scientific journal

Bioorganic chemistry of nyctinasty using functional probes
M Ueda, T Fujii, E Kato, T Sugimoto, N Kato
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 64, 2, 117, 129, Feb. 2006, [Peer-reviewed]
Japanese, Scientific journal

Bioorganic studies on plant movement, from natural products to its receptor
Mitsuru Shoji, Eisuke Kato, Yoko Nakamura, Tomohiko Fujii, Yoshiyuki Manabe, Minoru Ueda
CHEMICAL RECORD, 6, 6, 344, 355, 2006, [Peer-reviewed]
English, Scientific journal

Concise synthesis of glyconoamidines as affinity ligands for the purification of beta-glucosidase involved in control of some biological events including plant leaf movement
E Kato, T Kumagai, M Ueda
TETRAHEDRON LETTERS, 46, 29, 4865, 4869, Jul. 2005, [Peer-reviewed]
English, Scientific journal

Synthetic inhibitor of leaf-closure that reveals the biological importance of leaf-movement for the survival of leguminous plants
E Kato, H Nagano, S Yamamura, M Ueda
TETRAHEDRON, 59, 31, 5909, 5917, Jul. 2003, [Peer-reviewed]
English, Scientific journal

Fluorescence studies on nyctinasty using fluorescence labeled cis-p-coumaroylagmatine, a leaf-opening substance of Albizzia plants: existence of genus-specific receptor for leaf-movement factor
H Nagano, E Kato, S Yamamura, M Ueda
TETRAHEDRON LETTERS, 44, 14, 2953, 2956, Mar. 2003, [Peer-reviewed]
English, Scientific journal

Synthetic Inhibitor of Leaf-closure Designed on the Chemical Mechanism of Leaf-movement
E. Kato, H. Nagano, S. Yamamura, M.Ueda
Tetrahedron, 59, 31, 5909, 5917, Elsevier BV, 2003, [Peer-reviewed]
English, Scientific journal

Fluorescence studies on nyctinasty which suggest the existence of genus-specific receptors for leaf-movement factor
H Nagano, E Kato, S Yamamura, M Ueda
ORGANIC & BIOMOLECULAR CHEMISTRY, 1, 18, 3186, 3192, 2003, [Peer-reviewed]
English, Scientific journal

A novel leaf-movement inhibitor of a nyctinastic weed, Sesbania exaltata Cory, designed on a naturally occurring leaf-opening substance and its application to a potential, highly selective herbicide
N Takada, E Kato, K Ueda, S Yamamura, M Ueda
TETRAHEDRON LETTERS, 43, 43, 7655, 7658, Oct. 2002, [Peer-reviewed]
English, Scientific journal

α‐グルコシダーゼの阻害部位同定に向けた2‐アミノレゾルシノールのプローブ化研究
及川健一, 加藤英介, 川端潤, 日本農芸化学会大会講演要旨集, 2011, 177, 05 Mar. 2011
Japanese

基質認識機構を利用したα‐アミラーゼ阻害剤の合成と活性
加藤英介, 山田有二, 山田暁彦, 安藤まり子, 川端潤, 日本農芸化学会大会講演要旨集, 2011, 19, 05 Mar. 2011
Japanese

オニシモツケ地上部中の新規膵リパーゼ阻害成分の単離
山理嗣, 柴田敏郎, 細川敬三, 加藤英介, 川端潤, 日本農芸化学会大会講演要旨集, 2011, 69, 05 Mar. 2011
Japanese

インドネシア産植物由来α‐アミラーゼ阻害成分の探索
島田実幸, GUNAWAN‐PUTERI Maria, 加藤英介, 川端潤, 日本農芸化学会大会講演要旨集, 2011, 68, 05 Mar. 2011
Japanese

Candida albicansの菌糸形成に影響する消化管腔内因子
園山慶, 中田麻友美, 加藤英介, 日本農芸化学会大会講演要旨集, 2011, 269, 05 Mar. 2011
Japanese

フェノールカルボン酸類のラジカル消去機構(31)―水系での新規プロトカテキュ酸メチル二量体の生成―
上杉信太郎, 加藤英介, 川端潤, 日本農芸化学会東北支部大会プログラム・講演要旨集, 145th, 55, 27 Sep. 2010
Japanese

グルコース‐デオキシノジリマイシン複合体の合成とα‐アミラーゼ阻害活性
加藤英介, 山田有二, 山田暁彦, 安藤まり子, 川端潤, 日本農芸化学会東北支部大会プログラム・講演要旨集, 145th, 55, 27 Sep. 2010
Japanese

Kaempferol3‐O‐neohesperidosideのインスリン様活性に関する研究
山崎一諒, 飛鋪亮吾, 加藤英介, 川端潤, 天然有機化合物討論会講演要旨集, 52nd, 409, 414, 01 Sep. 2010
Japanese

フェノールカルボン酸類のラジカル消去機構(30)―水系での新規プロトカテキュ酸二量体の生成―
上杉信太郎, 加藤英介, 川端潤, 日本農芸化学会大会講演要旨集, 2010, 273, 05 Mar. 2010
Japanese

Kaempferol配糖体および関連化合物の合成とそのインスリン様活性
山崎一諒, 加藤英介, 川端潤, 日本農芸化学会大会講演要旨集, 2010, 46, 05 Mar. 2010
Japanese

イソフラボン配糖体puerarinの糖取込促進活性に関する構造活性相関研究
加藤英介, 川端潤, 日本農芸化学会大会講演要旨集, 2010, 46, 05 Mar. 2010
Japanese

2‐アミノレゾルシノール誘導体の合成とα‐グルコシダーゼ阻害活性評価
及川健一, 高橋敬典, 加藤英介, 加藤英介, 川端潤, 川端潤, 日本農芸化学会大会講演要旨集, 2010, 174, 05 Mar. 2010
Japanese

マウス盲腸内容物中に含まれるCandida albicans菌糸形成促進物質の探索
中田麻友美, 武村直紀, 秦枝里奈, 上杉信太郎, 加藤英介, 園山慶, 日本栄養・食糧学会大会講演要旨集, 63rd, 222, 01 May 2009
Japanese

光反応基を導入したバイカレイン誘導体の合成と応用
高橋敬典, 加藤英介, 川端潤, 日本農芸化学会大会講演要旨集, 2009, 201, 05 Mar. 2009
Japanese

Kaempferol配糖体のインスリン様作用と構造活性相関研究
山崎一諒, 加藤英介, 川端潤, 日本農芸化学会大会講演要旨集, 2009, 222, 05 Mar. 2009
Japanese

イソフラボン配糖体puerarinのインスリン様作用に関する研究
加藤英介, 川端潤, 日本農芸化学会大会講演要旨集, 2009, 221, 05 Mar. 2009
Japanese

米国コロンビア大学でのポスドク生活 : 中西研究室でのギンコライドに関する研究
加藤 英介, 化学と生物, 47, 2, 143, 147, 01 Feb. 2009
「海外だより」を執筆している現在から1年と2ヵ月前までアメリカ，ニューヨーク州コロンビア大学に留学していました．すでに日本に帰っている筆者が「海外だより」を書くのは少々違和感がありますが，留学中の経験など紹介させていただきます．筆者は特別深い理由があって留学を決めたのではなく，博士2年当時に企業への就職の意志があまりなかったため，ポスドク先として適当なところはないかと考えていました．特に国内・国外はあまり気にせず見繕っていましたが，結局は当時の教授の薦めもあって，コロンビア大学の中西香爾教授の研究室に決めました．, 社団法人 日本農芸化学会, Japanese

サブサイト認識を志向したα‐アミラーゼ阻害剤の設計と合成
岩野直哉, 加藤英介, 川端潤, 日本農芸化学会大会講演要旨集, 2008, 127, 05 Mar. 2008
Japanese

バイカレインのビニローグ誘導体のスクラーゼ阻害活性
高橋敬典, 加藤英介, 川端潤, 日本農芸化学会大会講演要旨集, 2008, 126, 05 Mar. 2008
Japanese

Huisgen環化反応を利用したコレステロール吸収阻害活性検定法の確立
鳥巣哲生, 加藤英介, 川端潤, 日本農芸化学会北海道支部・日本土壌肥料学会北海道支部・日本生物工学会北日本支部・日本応用糖質科学会北海道支部・北海道農芸化学協会合同学術講演会講演要旨, 2008, 24, 2008
Japanese

就眠運動のリズムを調節する鍵酵素の精製とその性質
加藤英介, 佐々木健彦, 上田実, 日本化学会講演予稿集, 87th, 2, 1244, 12 Mar. 2007
Japanese

Affinity Purification of the Key Enzyme .BETA.-Glucosidase Controlling Nyctinastic Rhythm Movement
KATO EISUKE, KUMAGAI TADAHIRO, UEDA MINORU, 日本化学会講演予稿集, 86th, 2, 1318, 13 Mar. 2006
Japanese

Synthesis of Glyconoamidines as a Potent Inhibitor of .BETA.-Glucosidase Using Non-protected Thionolactum.
KUMAGAI TADAHIRO, KATO EISUKE, UEDA MINORU, 日本化学会講演予稿集, 86th, 2, 1319, 13 Mar. 2006
Japanese

Bioorganic chemistry of nyctinasty using functional probes
M Ueda, T Fujii, E Kato, T Sugimoto, N Kato, JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 64, 2, 117, 129, Feb. 2006
Japanese

Bioorganic chemistry of nyctinasty using functional probes
M Ueda, T Fujii, E Kato, T Sugimoto, N Kato, JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 64, 2, 117, 129, Feb. 2006
Japanese

グルコノアミジン型阻害剤による就眠運動の鍵酵素β‐グルコシダーゼのアフィニティー精製
加藤英介, 熊谷忠浩, 上田実, 天然有機化合物討論会講演要旨集, 47th, 47, 229, 234, 15 Sep. 2005
Nyctinastic movement of leguminous plants is controlled by the glucosylated leaf-movement factor, whose concentration changes throughout the day, regulated by β-glucosidase. Therefore, in order to understand the controlling mechanism of the movement by circadian clock, purification of this key enzymeis essential. Many isozymes of β-glucosidase are known to exist in plant body. To purify the key enzyme from this mixture, affinity chromatography is a powerful tool. We have tried two affinity gel 4 and 5, which is an usual tool used for purification of β-glucosidase. But they were both not effective, from the luck of aglycon part or the low inhibition constant. According to this experiment, we concluded that affinity ligand should be an analog of the leaf-movement factor, and at the same time it should be a strong inhibitor. Gluconoamidine is known to show strong inhibition toward β-glucosidase. Thus, we have planed to synthesize 7, an analog of leaf-movement factor with gluconoamidine part, instead of glucose as the glucoside part. Several methods are known for the synthesis of gluconoamidine compound using thionolactam(6) and amine compound. But there are several restriction. 1) Benzyl protected sugar derivative are necessary 2) Needs of a reactive amine group. And also, in some cases the epimerization at C2 of the sugar moiety occurs. To overcome these restrictions, we have developed a novel method for the synthesis of gluconoamidine compound. And by employing this method we have synthesized 7. Compound 7 showed strong and selective inhibition toward commercially available β-glucosidase. Encouraged by this result we synthesized an affinity gel 16, using 7 as a ligand. Purification of the crude enzyme, extracted from Lespedeza cuneata, by affinity gel 16 was effective. We are now working on further purification of the key enzyme., Symposium on the chemistry of natural products, Japanese

植物就眠運動の鍵酵素精製を目指したグルコノアミジン型アフィニティーゲルの開発
加藤英介, 熊谷忠浩, 上田実, 化学系学協会東北大会プログラムおよび講演予稿集, 2005, 186, 15 Sep. 2005
Japanese

44 Affinity Purification of the Key Enzyme β-Glucosidase Controlling Nyctinastic Movement of Leguminous Plant by Gluconoamidine Type Inhibitor
Kato Eisuke, Kumagai Tadahiro, Ueda Minoru, Symposium on the Chemistry of Natural Products, symposium papers, 0, 47, 229, 234, 15 Sep. 2005
Nyctinastic movement of leguminous plants is controlled by the glucosylated leaf-movement factor, whose concentration changes throughout the day, regulated by β-glucosidase. Therefore, in order to understand the controlling mechanism of the movement by circadian clock, purification of this key enzymeis essential. Many isozymes of β-glucosidase are known to exist in plant body. To purify the key enzyme from this mixture, affinity chromatography is a powerful tool. We have tried two affinity gel 4 and 5, which is an usual tool used for purification of β-glucosidase. But they were both not eff..., Symposium on the chemistry of natural products, Japanese

グルコノアミジン類の効率的合成と就眠運動の鍵酵素β‐グルコシダーゼの精製
加藤英介, 熊谷忠浩, 上田実, 万有生命科学振興国際交流財団仙台シンポジウム, 16th, 48, 28 May 2005
Japanese

Purification study of the key enzyme .BETA.-glucosidase controlling nyctinasty using amidine type leaf-opening substance analog
KATO EISUKE, KUMAGAI TADAHIRO, UEDA MINORU, 日本化学会講演予稿集, 85th, 2, 881, 11 Mar. 2005
Japanese

Purification of .BETA.-glucosidase, the key enzyme of nyctinasty, which controls the nyctinastic movement of leguminous plants
KATO EISUKE, YAMAMURA SHOSUKE, UEDA MINORU, 日本化学会講演予稿集, 84th, 2, 1028, 11 Mar. 2004
Japanese

Development of Inhibitor of Nyctinasty Based on the Leaf-Opening Substance and Its Application for a Highly Selective Agrochemical
KATO EISUKE, SUGIMOTO TAKANORI, YAMAMURA SHOSUKE, UEDA MINORU, 日本化学会講演予稿集, 83rd, 2, 918, 03 Mar. 2003
Japanese

The bioorganic Chemical study about nyctinastic leafmovement of Albizzia julibrissin Durazz with fluorescence probe compounds
NAGANO HIDEHARU, KATO EISUKE, YAMAMURA SHOSUKE, UEDA MINORU, 日本化学会講演予稿集, 83rd, 2, 918, 03 Mar. 2003
Japanese

The Leaf-opening Substance of Sesbania speciosa Taub. and Application for a Highly Selective Agrochemical
KATO EISUKE, TAKADA AKIRA, UEEDA KATSUHIRO, YAMAMURA SHOSUKE, UEDA MINORU, 日本化学会講演予稿集, 82nd, 200, 10 Sep. 2002
Japanese

植物はなぜ眠るのか? 就眠運動阻害剤を用いたアプローチと環境調和型アグロケミカルへの応用
加藤英介, 杉本貴謙, 沢井善行, 上江田捷博, 高田晃, 山村庄亮, 上田実, 天然有機化合物討論会講演要旨集, 44th, 44, 397, 402, 01 Sep. 2002
Most legumes close their leaves in the evening, and open them at the morning. This movement is called nyctinasty. "Why does the leguminous plant sleep?" is the unsolvable question about the nyctinasty. Darwin and Bunning had a view to this problem, for example Darwin said that it is a movement to guard against the coldness of the night, and Bunning said it is to prevent reset of the biological clock by moonlight. But it couldn't be a theory cause they didn't have much supporting data. On base of the mechanism of nyctinastic movement, we have synthesized an inhibitor (2) of nyctinastic movement from the leaf-opening substance of Cassia mimosoides L., thinking that legumes don't sleep will be a solution for the question. 2 had successfully inhibited nyctinastic movement and made the plant insomnia. Also we have found that insomnia plant withers in a week or two. And gave a key to solve the question "Why does the leguminous plant sleep?" that nyctinastic movement is essential for leguminous plants to survive. Two factors, that nyctinastic movement is essential for leguminous plants to survive, and leaf-opening substance is specific to each genus, suggested the use of nyctinastic movement inhibitor as the highly specific agrochemical. We have targeted Sesbania exaltata Cory, the weed becoming a problem on soybean plantation in USA. From the extraction of the Sesbania speciosa Taub., predicted to have the same leaf-opening substance with the S. exaltata Cory, we have isolated potassium 4-O-β-D-glucopyranosyl-trans-p-coumarate (11) as the leaf-opening factor. 11 was confirmed to be specific to the Sesbania genus, so next we synthesized an inhibitor (12 and 13) from 11. The synthesized 12 and 13 was first confirmed to be specific to Sesbania genus, and then used to S. exaltata Cory. 12 and 13 had successfully withered the plant and showed the possibility for the use of nyctinastic movement inhibitor as the highly specific agrochemical., Symposium on the chemistry of natural products, Japanese

68(P-47) Why does the leguminous plant sleep? : Chemical approach using synthetic inhibitor of nyctinasty
Kato Eisuke, Sugimoto Takanori, Sawai Yoshiyuki, Ueda Katsuhiro, Takada Noboru, Yamamura Shosuke, Ueda Minoru, Symposium on the Chemistry of Natural Products, symposium papers, 0, 44, 397, 402, 01 Sep. 2002
Most legumes close their leaves in the evening, and open them at the morning. This movement is called nyctinasty. "Why does the leguminous plant sleep?" is the unsolvable question about the nyctinasty. Darwin and Bunning had a view to this problem, for example Darwin said that it is a movement to guard against the coldness of the night, and Bunning said it is to prevent reset of the biological clock by moonlight. But it couldn't be a theory cause they didn't have much supporting data. On base of the mechanism of nyctinastic movement, we have synthesized an inhibitor (2) of nyctinastic movem..., Symposium on the chemistry of natural products, Japanese

Chemical Study on the Leaf-opening Substance of Sesbania speciosa Taub.
KATO EISUKE, TAKADA NOBORU, UEDA KATSUHIRO, YAMAMURA SHOSUKE, UEDA MINORU, 日本化学会講演予稿集, 81st, 2, 737, 11 Mar. 2002
Japanese

TIE2 activating components in Guava leaves and Indian dates and their effects on Vascular Endothelial Cells　　　　　　　　　　　　　　　
五十嵐早紀, 日置彩香, 石神滉己, 内田尚徳, 加藤 英介
日本農芸化学会2025年度大会, 07 Mar. 2025, Poster presentation
04 Mar. 2025 - 08 Mar. 2025

Functional analysis of bitter taste receptors Tas2r108 and Tas2r126 in adipocytes　　　　　　　　　　　　　　　
足立悠輔, 大島翔汰, 加藤 英介
日本農芸化学会2025年度大会, 07 Mar. 2025, Poster presentation
04 Mar. 2025 - 08 Mar. 2025

グアバ葉・インディアンデーツからのTIE2活性化成分の探索と血管内皮細胞に対する効果の検証　　　　　　　　　　　　　　　
五十嵐 早紀, 日置 彩香, 石神 滉己, 内田 尚徳, 加藤 英介
令和6年度 日本栄養・食糧学会東北支部 （第58回大会） 日本栄養・食糧学会北海道支部（第54回大会） 合同支部大会およびシンポジウム, 08 Dec. 2024, Oral presentation
07 Dec. 2024 - 08 Dec. 2024

カシス、アカジソ、ミオイノシトールが雌性マウスの性ホルモン分泌に与える影響の検証　　　　　　　　　　　　　　　
足立悠輔, 加藤英介, 稲垣洋介
2024年度 日本農芸化学会北海道支部 第２回学術講演会, 01 Dec. 2024, Oral presentation

苦味受容体Tas2r108 はcAMP の調節を介して脂肪細胞の分化を制御する　　　　　　　　　　　　　　　
島翔汰, 足立悠輔, 加藤英介
2024年度 日本農芸化学会北海道支部 第２回学術講演会, 01 Dec. 2024, Oral presentation

LOH症候群を予防する食品成分の探索と動物モデルによる効果の実証　　　　　　　　　　　　　　　
加藤英介, 稲垣洋介, 足立悠輔, 家代岡 広海, 長世 智朗, 寺田 直史, 鶴間 あい
第24回日本メンズヘルス医学会, 21 Sep. 2024, Oral presentation

男性更年期障害予防に有用なテストステロン量を増加させる食品成分　　　　　　　　　　　　　　　
加藤英介
日本食品分析学会 令和6年度学術集会, 18 Sep. 2024, Nominated symposium
[Invited]

ポリフェノールによる血管構造安定化受容体TIE2の活性化　　　　　　　　　　　　　　　
五十嵐早紀, 日置彩香, 坂丸直人, 鈴木朝日, 黒川美保子, 加藤英介
第17回日本ポリフェノール学会 学術集会, 30 Aug. 2024, Poster presentation

苦味受容体Tas2r108の発現調節により3T3-L1細胞の成熟脂肪細胞への分化は抑制される　　　　　　　　　　　　　　　
大島 翔汰, 佐々木 琴美, 鶴間 あい, 木村 駿介, 加藤 英介
日本農芸化学会2024年度大会, 26 Mar. 2024, Oral presentation

膵リパーゼを阻害する大麦若葉由来タンパク質の阻害活性に重要なアミノ酸配列の解析　　　　　　　　　　　　　　　
山口莉奈, 佐々木琴美, 鶴間あい, 加藤英介
日本農芸化学会2024年度大会, 26 Mar. 2024, Oral presentation

カシス、アカジソ、甜茶に含まれるテストステロン分泌促進活性成分の機能解析とin vivoでの検証　　　　　　　　　　　　　　　
足立 悠輔, 家代岡 広海, 鶴間 あい, 寺田 直史, 長世 智朗, 加藤 英介, 稲垣 洋介
日本農芸化学会2024年度大会, 26 Mar. 2024, Oral presentation

健康寿命を延ばす効果のある機能性成分の探索　　　　　　　　　　　　　　　
加藤英介
４大学＋１企業アグリ食品セミナー「食の未来を創るパートナーシップ：産学連携がもたらす機能性革新」, 2024, Public discourse

糖代謝を調節して血糖値を「下げる」機能性食品の開発　　　　　　　　　　　　　　　
加藤英介
第７回「食と健康」研究会, 22 Apr. 2014, Japanese, Public discourse
[Invited]

ヒドロキシアミンの骨格筋細胞に対する糖取り込み促進作用とそ の作用機構解析　　　　　　　　　　　　　　　
木村 太郎, 加藤 英介, 町川 司, 木村 駿介, 片山 紳司, 川端 潤
日本農芸化学会2014年度大会, 29 Mar. 2014, Japanese, Oral presentation
[Domestic Conference]

マカ由来のインスリン様活性物質の探索　　　　　　　　　　　　　　　
片山 紳司, 町川 司, 加藤 英介, 川端 潤
日本農芸化学会2014年度大会, 27 Mar. 2014, Japanese, Oral presentation
[Domestic Conference]

レモングラスからのインスリン様活性物質探索　　　　　　　　　　　　　　　
町川 司, 加藤 英介, 川端 潤
日本農芸化学会2014年度大会, 27 Mar. 2014, Japanese, Oral presentation
[Domestic Conference]

蓮芯に含まれる筋細 胞の糖取り込み促進活性成分の探索　　　　　　　　　　　　　　　
加藤 英介, 木村 太郎, 稲垣 洋 介, 藤田 裕之, 川端 潤
日本農芸化学会2014年度大会, 27 Mar. 2014, Japanese, Oral presentation
[Domestic Conference]

ヒドロキシアミンの糖取り込み促進作用とその作用機構解析　　　　　　　　　　　　　　　
木村 太郎, 加藤 英介, 町川 司, 木村 駿介, 片山 紳司, 川端 潤
平成２５年度公益社団法人日本農芸化学会北海道支部講演会, 30 Nov. 2013, Japanese, Oral presentation
[Domestic Conference]

Food Biochemistry II　　　　　　　　　　　　　　　
Hokkaido University
Oct. 2018 - Present

Organic chemistry 2　　　　　　　　　　　　　　　
Hokkaido University
Sep. 2018 - Present

Advanced Review of Food Science　　　　　　　　　　　　　　　
Hokkaido University
2016 - Present

Laboratry Work on Chemistry II　　　　　　　　　　　　　　　
Hokkaido University
2010 - Present

化学II　　　　　　　　　　　　　　　
北海道大学

Apr. 2024
日本栄養・食糧学会　　　　　　　　　　　　　　　

Functional analysis of bitter taste receptors in adipocytes and hepatocytes
Grants-in-Aid for Scientific Research
01 Apr. 2023 - 31 Mar. 2026
加藤 英介
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 23K05107

健康寿命の延長を目指したコメ糠成分の機能解析　　　　　　　　　　　　　　　
(公財) エリザベス・アーノルド富士財団 令和4年度学術研究助成
Sep. 2022 - Aug. 2023
加藤 英介
(公財) エリザベス・アーノルド富士財団, 北海道大学

苦味受容体を介した食品の健康機能　　　　　　　　　　　　　　　
一般財団法人糧食研究会 2022年度一般公募研究
Aug. 2022 - Aug. 2023
加藤 英介
一般財団法人糧食研究会, 北海道大学

男性更年期対策食品原料の開発手法の構築
産学が連携した研究開発成果の展開 研究成果展開事業 研究成果最適展開支援プログラム(A-STEP) トライアウト トライアウト
2022 - 2023
加藤 英介
ストレスや加齢によりテストステロンが欠乏すると男性も更年期障害を生じ、種々の体調不良の原因となる。本課題では、「食」による男性更年期予防を目指し、男性更年期対策食品原料の開発手法の構築と、実験動物レベルでのテストステロン量増加効果の実証を行い、男性更年期対策食品の開発基盤を構築する。
科学技術振興機構, 北海道大学, Principal investigator

体内に発現する苦味受容体の機能解析　　　　　　　　　　　　　　　
令和2年度 (公財)浦上食品・食文化振興財団 学術研究助成
Oct. 2020 - Mar. 2022
加藤 英介
公益財団法人 浦上食品・食文化振興財団, 北海道大学

食品成分が標的とする体内の苦味受容体の役割を探る
科学研究費補助金（基盤研究(C)）
Apr. 2019 - Mar. 2022
加藤英介
日本学術振興会, Principal investigator, Competitive research funding

米糠成分のステロイドホルモン生合成促進作用
令和元年度学術研究助成
Apr. 2019 - Mar. 2020
加藤英介
公益財団法人エリザベス・アーノルド富士財団, Principal investigator, Competitive research funding

苦味成分による脂肪細胞機能調節の解析　　　　　　　　　　　　　　　
平成30年度 学術研究奨励金
Jul. 2018 - Jun. 2019
加藤英介
公益財団法人 三島海雲記念財団, Principal investigator, Competitive research funding

消化管上皮細胞機能を調節する食品素材と生物活性成分の探索 研究課題　　　　　　　　　　　　　　　
科学研究費補助金(若手研究(B))
Apr. 2017 - Mar. 2019
加藤英介
文部科学省, Principal investigator, Competitive research funding

Study on glucose uptake enhancement activity of plant derived compounds with unique and high polar structure
Grants-in-Aid for Scientific Research
2013 - 2015
KATO Eisuke
Diabetes mellitus is a disease that shows high blood glucose level. The disease is currently considered a worldwide problem and development of a method for treatment is highly required task. However, current medicines are developed on a intense to control blood glucose and prevent complications and thus, they are not suitable for completely curing the disease. In this study, bioactive compound that enhance the glucose uptake of muscle cells are studied as a candidate for diabetes mellitus curing compound. The function of the glucose uptake enhancer neohesperidose was revealed and several new glucose uptake enhancers including higenamine glucoside, hydroxylamine, unsaturated fatty acids, piperine were discovered. Also, the function of higenamine glucoside, hydroxylamine are revealed from inhibitor co-incubation experiment.
Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, Principal investigator, Competitive research funding, 25750391

高齢者の筋力維持に有用な食素材の探索　　　　　　　　　　　　　　　
研究シーズ発掘補助金（札幌フードTalent補助金）
Aug. 2013 - Mar. 2014
加藤英介
公益財団法人 北海道科学技術総合振興センター, Principal investigator, Competitive research funding

Molecular design of amylase inhibitor based on the substrate recognition property of the enzyme
Grants-in-Aid for Scientific Research
2009 - 2011
KAWABATA Jun, KATO Eisuke
Inhibition of the pancreaticα-amylase is useful for the treatment of obesity and diabetes mellitus. However, not many small molecule inhibitors are known for this enzyme due to its characteristic substrate recognition which recognizes chained glucoses. We used this characteristic mode of substrate recognition to design new small moleculeα-amylase inhibitors and synthesized them. These synthetic inhibitors revealed a useful property of the pancreaticα-amylase for further development of the inhibitor.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 21603001