Miyamoto Naoki
| Faculty of Engineering Applied Quantum Science and Engineering Quantum Engineering for Life Science and Medicine | Associate Professor |
Last Updated :2025/11/06
■Researcher basic information
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Researcher number
- 00552879
J-Global ID
Research Field
Educational Organization
- Bachelor's degree program, School of Engineering
- Master's degree program, Graduate School of Engineering
- Doctoral (PhD) degree program, Graduate School of Engineering
■Career
Career
- Jun. 2018 - Present
Hokkaido University, Faculty of Engineering, 准教授 - Apr. 2014 - May 2018
Hokkaido University Hospital, Department of Radiation Medicine, Assistant Professor - Apr. 2008 - Mar. 2013
Graduate School of Medicine, Department of Medical Physics, Assistant Professor - Apr. 2006 - Mar. 2008
Graduate School of Engineering, Quantum Beam System Engineering, Postdoctoral Fellow
Educational Background
■Research activity information
Awards
- May 2025, 第38回高精度放射線外部照射部会学術大会, 優秀賞
心疾患に対する心拍・呼吸迎撃陽子線治療 システムの実現可能性に関するイン・シリコ検証
宮本直樹;加藤徳雄;山田貴啓;金平孝博;高尾聖心;松浦妙子;小橋啓司;橋本孝之;青山英史 - Sep. 2019, 日本癌学会, 第9回 JCA-CHAAO賞
動体追跡技術と同期照射技術を用いた高精度放射線治療の開発と臨床研究
白土 博樹;清水 伸一;鬼丸 力也;品川 尚文;阿保 大介;加藤 徳雄;梅垣 菊男;石川 正純;宮本 直樹;青山 英史 - Apr. 2017, 公益社団法人 発明協会, 恩賜発明賞
動体追跡粒子線がん治療装置の発明
藤井祐介;梅川徹;梅澤真澄;白土博樹;梅垣菊男;宮本直樹;松浦妙子 - Sep. 2012, 医学物理学会, Outstanding Research Award
Real-time tumor-tracking system with single fluoroscopic imaging
Naoki Miyamoto;Masayori Ishikawa;Kenneth Sutherland;Ryusuke Suzuki;Taeko Matsuura;Chie Toramatsu;Seishin Tako;Hideaki Nihongi;Shinichi Shimizu;Kikuo Umegaki;Hiroki Shirato - Oct. 2011, Japanese Society of Medical Physics, Outstanding Poster Award
Respiratory motion of lung tumor determined by trajectory data of multiple fiducial markers in real-time tumor-tracking radiotherapy
Naoki Miyamoto;Kanako Otomo;Kenneth Sutherland;Ryusuke Suzuki;Taeko Matsuura;Chie Toramatsu;Seishin Tako;Hideaki Nihongi;Rumiko Kinoshita;Shinichi Shimizu;Rikiya Onimaru;Masayori Ishikawa;Kikuo Umegaki;Hiroki Shirato - Oct. 2007, Japanese Society for Non-Destructive Inspection, Young Scientists Award
Non-destructive analysis of nuclide distribution by neutron resonance absorption CT utilizing a small pulsed neutron source
Naoki Miyamoto;Tamotsu Kozaki;Satoshi Tomioka;Takashi Kamiyama
Papers
- Normal tissue complication probability model for severe radiation-induced lymphopenia in patients with pancreatic cancer treated with concurrent chemoradiotherapy
Fuki Koizumi, Norio Katoh, Takahiro Kanehira, Yasuyuki Kawamoto, Toru Nakamura, Tatsuhiko Kakisaka, Miyako Myojin, Noriaki Nishiyama, Akio Yonesaka, Manami Otsuka, Rikiya Takashina, Hideki Minatogawa, Hajime Higaki, Yusuke Uchinami, Hiroshi Taguchi, Kentaro Nishioka, Koichi Yasuda, Naoki Miyamoto, Isao Yokota, Keiji Kobashi, Hidefumi Aoyama
Physics and Imaging in Radiation Oncology, 100690, 100690, Elsevier BV, Dec. 2024, [Peer-reviewed]
Scientific journal - Investigation of interfractional range variation owing to anatomical changes with beam directions based on water equivalent thickness in proton therapy for pancreatic cancer.
Yuhei Kikkawa, Hideaki Ueda, Yusuke Uchinami, Norio Katoh, Hidefumi Aoyama, Yoichi M Ito, Kohei Yokokawa, Ye Chen, Taeko Matsuura, Naoki Miyamoto, Seishin Takao
Journal of radiation research, 08 Oct. 2024, [Peer-reviewed], [International Magazine]
English, Scientific journal, To assess the interfractional anatomical range variations (ARVs) with beam directions and their impact on dose distribution in intensity modulated proton therapy, we analyzed water equivalent thickness (WET) from 10 patients with pancreatic cancer. The distributions of the interfractional WET difference ($\Delta{\mathrm{WET } }^{\theta }$) across 360° were visualized using polar histograms. Interfractional ARVs were evaluated using the mean absolute error and ΔWET pass rate, indicating the percentage of $\Delta \mathrm{WE},{\mathrm{T } }^{\theta }$ < thresholds. The impact on dose distribution in proton therapy was evaluated based on two treatment plans for 40 Gy(RBE)/5 fractions: 'Plan A', using two beam angles, in which the target was closest to the body surface among four perpendicular directions; and 'Plan B', using two beam angles with small ARVs. Analysis revealed individual variations in angular trends of interfractional ARVs. Three distinct trends were identified: Group 1 exhibited small ARVs around posterior directions; Group 2 exhibited small ARVs except ~60°; Group 3 demonstrated minimal ARVs only ~90°. In dose evaluation, while 150° and 210° were selected in Plan B for 9 out of 10 patients, for the remaining patient, 60° and 90° were chosen. Comparing dose volume histogram parameters for all patients, Plan B significantly reduced target coverage loss while maintaining organ-at-risk sparing comparable to Plan A. These results demonstrated that selecting beam angles with small interfractional ARVs for each patient enhances the robustness of dose distribution, reducing target coverage loss. - Application of motion prediction based on a long short-term memory network for imaging dose reduction in real-time tumor-tracking radiation therapy.
Kazuki Numakura, Seishin Takao, Taeko Matsuura, Kouhei Yokokawa, Ye Chen, Yusuke Uchinami, Hiroshi Taguchi, Norio Katoh, Hidefumi Aoyama, Satoshi Tomioka, Naoki Miyamoto
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 125, 104507, 104507, Sep. 2024, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, PURPOSE: To demonstrate the possibility of using a lower imaging rate while maintaining acceptable accuracy by applying motion prediction to minimize the imaging dose in real-time image-guided radiation therapy. METHODS: Time-series of three-dimensional internal marker positions obtained from 98 patients in liver stereotactic body radiation therapy were used to train and test the long-short-term memory (LSTM) network. For real-time imaging, the root mean squared error (RMSE) of the prediction on three-dimensional marker position made by LSTM, the residual motion of the target under respiratory-gated irradiation, and irradiation efficiency were evaluated. In the evaluation of the residual motion, the system-specific latency was assumed to be 100 ms. RESULTS: Except for outliers in the superior-inferior (SI) direction, the median/maximum values of the RMSE for imaging rates of 7.5, 5.0, and 2.5 frames per second (fps) were 0.8/1.3, 0.9/1.6, and 1.2/2.4 mm, respectively. The median/maximum residual motion in the SI direction at an imaging rate of 15.0 fps without prediction of the marker position, which is a typical clinical setting, was 2.3/3.6 mm. For rates of 7.5, 5.0, and 2.5 fps with prediction, the corresponding values were 2.0/2.6, 2.2/3.3, and 2.4/3.9 mm, respectively. There was no significant difference between the irradiation efficiency with and that without prediction of the marker position. The geometrical accuracy at lower frame rates with prediction applied was superior or comparable to that at 15 fps without prediction. In comparison with the current clinical setting for real-time image-guided radiation therapy, which uses an imaging rate of 15.0 fps without prediction, it may be possible to reduce the imaging dose by half or more. CONCLUSIONS: Motion prediction can effectively lower the frame rate and minimize the imaging dose in real-time image-guided radiation therapy. - Clinical application of real-time tumor-tracking for stereotactic volumetric modulated arc therapy for liver tumors.
Naoki Miyamoto, Norio Katoh, Takahiro Kanehira, Kohei Yokokawa, Ryusuke Suzuki, Yusuke Uchinami, Hiroshi Taguchi, Daisuke Abo, Hidefumi Aoyama
Physics and imaging in radiation oncology, 31, 100623, 100623, Jul. 2024, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal, Real-time tumor-tracking volumetric modulated arc therapy (RT-VMAT) enabling beam-gating based on continuous X-ray tracking of the three-dimensional position of internal markers is relevant for moving tumors. Dose-volume characteristics and treatment time were evaluated in ten consecutive patients who underwent liver stereotactic body radiation therapy with RT-VMAT. Target dose conformity and sparing of the stomach and the intestine were improved comparing RT-VMAT with RT-3D conformal radiotherapy. The mean treatment time for each fraction was less than 10 min. RT-VMAT could be effective, especially for targets located adjacent to organs at risk. - A novel method for measurements of sleep/wake states, feeding and drinking behaviors using the tracking technique of 3D positions in freely moving mice
Hamada T, Sutherland K, Ishikawa M, Saito J, Miyamoto N, Honma S, Shirato H, Honma K-I ( * Correspondence)
Biochemical and Biophysical Research Communications, Jul. 2024, [Peer-reviewed]
English, Scientific journal - A new predictive parameter for dose‐volume metrics in intensity‐modulated radiation therapy planning for prostate cancer: Initial phantom study
Yuki Saito, Ryusuke Suzuki, Naoki Miyamoto, Kenneth Lee Sutherland, Takahiro Kanehira, Masaya Tamura, Takashi Mori, Kentaro Nishioka, Takayuki Hashimoto, Hidefumi Aoyama
Journal of Applied Clinical Medical Physics, Apr. 2024, [Peer-reviewed]
Scientific journal - Impact of adaptive radiotherapy on survival in locally advanced nasopharyngeal carcinoma treated with concurrent chemoradiotherapy.
Yusuke Uchinami, Koichi Yasuda, Hideki Minatogawa, Yasuhiro Dekura, Noboru Nishikawa, Rumiko Kinoshita, Kentaro Nishioka, Norio Katoh, Takashi Mori, Manami Otsuka, Naoki Miyamoto, Ryusuke Suzuki, Keiji Kobashi, Yasushi Shimizu, Jun Taguchi, Nayuta Tsushima, Satoshi Kano, Akihiro Homma, Hidefumi Aoyama
Radiation oncology journal, 42, 1, 74, 82, Mar. 2024, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: To investigate the clinical significance of adaptive radiotherapy (ART) in locally advanced nasopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS: Eligible patients were treated with concurrent chemoradiotherapy using IMRT. Planning computed tomography in ART was performed during radiotherapy, and replanning was performed. Since ART was started in May 2011 (ART group), patients who were treated without ART up to April 2011 (non-ART group) were used as the historical control. The Kaplan-Meier method was used to calculate overall survival (OS), locoregional recurrence-free survival (LRFS), progression-free survival (PFS), and distant metastasis-free survival (DMFS). LRFS for the primary tumor (LRFS_P) and regional lymph node (LRFS_LN) were also studied for more detailed analysis. Statistical significance was evaluated using the log-rank test for survival. RESULTS: The ART group tended to have higher radiation doses. The median follow-up period was 127 months (range, 10 to 211 months) in the non-ART group and 61.5 months (range, 5 to 129 months) in the ART group. Compared to the non-ART group, the ART group showed significantly higher 5-year PFS (53.8% vs. 81.3%, p = 0.015) and LRFS (61.2% vs. 85.3%, p = 0.024), but not OS (80.7% vs. 80.8%, p = 0.941) and DMFS (84.6% vs. 92.7%, p = 0.255). Five-year LRFS_P was higher in the ART group (61.3% vs. 90.6%, p = 0.005), but LRFS_LN did not show a significant difference (91.9% vs. 96.2%, p = 0.541). CONCLUSION: Although there were differences in the patient backgrounds between the two groups, this study suggests the potential effectiveness of ART in improving locoregional control, especially in the primary tumor. - Technical note: Application of an optical hydrophone to ionoacoustic range detection in a tissue-mimicking agar phantom.
Shota Sueyasu, Koki Kasamatsu, Taisuke Takayanagi, Ye Chen, Yasutoshi Kuriyama, Yoshihiro Ishi, Tomonori Uesugi, Wolfgang Rohringer, Mehmet Burcin Unlu, Nobuki Kudo, Kohei Yokokawa, Seishin Takao, Naoki Miyamoto, Taeko Matsuura
Medical physics, 21 Dec. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Ionoacoustics is a promising approach to reduce the range uncertainty in proton therapy. A miniature-sized optical hydrophone (OH) was used as a measuring device to detect weak ionoacoustic signals with a high signal-to-noise ratio in water. However, further development is necessary to prevent wave distortion because of nearby acoustic impedance discontinuities while detection is conducted on the patient's skin. PURPOSE: A prototype of the probe head attached to an OH was fabricated and the required dimensions were experimentally investigated using a 100-MeV proton beam from a fixed-field alternating gradient accelerator and k-Wave simulations. The beam range of the proton in a tissue-mimicking phantom was estimated by measuring γ-waves and spherical ionoacoustic waves with resonant frequency (SPIRE). METHODS: Four sizes of probe heads were fabricated from agar blocks for the OH. Using the prototype, the γ-wave was detected at distal and lateral positions to the Bragg peak on the phantom surface for proton beams delivered at seven positions. For SPIRE, independent measurements were performed at distal on- and off-axis positions. The range positions were estimated by solving the linear equation using the sensitive matrix for the γ-wave and linear fitting of the correlation curve for SPIRE; they were compared with those measured using a film. RESULTS: The first peak of the γ-wave was undistorted with the 3 × 3 × 3-cm3 probe head used at the on-axis and 3-cm off-axis positions. The range positions estimated by the γ-wave agreed with the film-based range in the depth direction (the maximum deviation was 0.7 mm), although a 0.6-2.1 mm deviation was observed in the lateral direction. For SPIRE, the deviation was <1 mm for the two measurement positions. CONCLUSIONS: The attachment of a relatively small-sized probe head allowed the OH to measure the beam range on the phantom surface. - Real-time tumor-tracking radiotherapy with SyncTraX for primary liver tumors requiring isocenter shift†.
Yusuke Uchinami, Naoki Miyamoto, Daisuke Abo, Ryo Morita, Koji Ogawa, Tatsuhiko Kakisaka, Ryusuke Suzuki, Tomohiko Miyazaki, Hiroshi Taguchi, Norio Katoh, Hidefumi Aoyama
Journal of radiation research, 22 Nov. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, The SyncTraX series enables real-time tumor-tracking radiotherapy through the real-time recognition of a fiducial marker using fluoroscopic images. In this system, the isocenter should be located within approximately 5-7.5 cm from the marker, depending on the version, owing to the limited field of view. If the marker is placed away from the tumor, the isocenter should be shifted toward the marker. This study aimed to investigate stereotactic body radiotherapy (SBRT) outcomes of primary liver tumors treated with SyncTraX in cases where the isocenter was shifted marginally or outside the planning target volume (PTV). Twelve patients with 13 liver tumors were included in the analysis. Their isocenter was shifted toward the marker and was placed marginally or outside the PTV. The prescribed doses were generally 40 Gy in four fractions or 48 Gy in eight fractions. The overall survival (OS) and local control (LC) rates were calculated using the Kaplan-Meier method. All patients completed the scheduled SBRT. The median distance between the fiducial marker and PTV centroid was 56.0 (interquartile range [IQR]: 52.7-66.7) mm. By shifting the isocenter toward the marker, the median distance between the marker and isocenter decreased to 34.0 (IQR: 33.4-39.7) mm. With a median follow-up period of 25.3 (range: 6.9-70.0) months, the 2-year OS and LC rates were 100.0% (95% confidence interval: 100-100). An isocenter shift makes SBRT with SyncTraX feasible in cases where the fiducial marker is distant from the tumor. - Wavefront restoration from lateral shearing data using spectral interpolation
Satoshi Tomioka, Naoki Miyamoto, Yuji Yamauchi, Yutaka Matsumoto, Samia Heshmat
Applied Optics, 10 Oct. 2023, [Peer-reviewed]
Scientific journal - Predicting the daily gastrointestinal doses of stereotactic body radiation therapy for pancreatic cancer based on the shortest distance between the tumor and the gastrointestinal tract using daily computed tomography images
Yusuke Uchinami, Takahiro Kanehira, Keiji Nakazato, Yoshihiro Fujita, Fuki Koizumi, Shuhei Takahashi, Manami Otsuka, Koichi Yasuda, Hiroshi Taguchi, Kentaro Nishioka, Naoki Miyamoto, Kohei Yokokawa, Ryusuke Suzuki, Keiji Kobashi, Keita Takahashi, Norio Katoh, Hidefumi Aoyama
BJR|Open, 5, 1, British Institute of Radiology, Aug. 2023, [Peer-reviewed]
Scientific journal, Objectives:
We aimed to investigate whether daily computed tomography (CT) images could predict the daily gastroduodenal, small intestine, and large intestine doses of stereotactic body radiation therapy (SBRT) for pancreatic cancer based on the shortest distance between the gross tumor volume (GTV) and gastrointestinal (GI) tract.
Methods:
Twelve patients with pancreatic cancer received SBRT of 40 Gy in five fractions. We recalculated the reference clinical SBRT plan (PLANref) using daily CT images and calculated the shortest distance from the GTV to each GI tract. The maximum dose delivered to 0.5 cc (D0.5cc) was evaluated for each planning at-risk volume of the GI tract. Spearman’s correlation test was used to determine the association between the daily change in the shortest distance (Δshortest distance) and the ratio of ΔD0.5cc dose to D0.5cc dose in PLANref (ΔD0.5cc/PLANref) for quantitative analysis.
Results:
The median shortest distance in PLANref was 0 mm in the gastroduodenum (interquartile range, 0–2.7), 16.7 mm in the small intestine (10.0–23.7), and 16.7 mm in the large intestine (8.3–28.1 mm). The D0.5cc of PLANref in the gastroduodenum was >30 Gy in all patients, with 10 (83.3%) having the highest dose. A significant association was found between the Δshortest distance and ΔD0.5cc/ PLANref in the small or large intestine (p < 0.001) but not in the gastroduodenum (p = 0.404).
Conclusions:
The gastroduodenum had a higher D0.5cc and predicting the daily dose was difficult. Daily dose calculations of the GI tract are recommended for safe SBRT.
Advances in knowledge:
This study aimed to predict the daily doses in SBRT for pancreatic cancer from the shortest distance between the GTV and the gastrointestinal tract. Daily changes in the shortest distance can predict the daily dose to the small or large intestines, but not to the gastroduodenum. - Evaluation of short-term gastrointestinal motion and its impact on dosimetric parameters in stereotactic body radiation therapy for pancreatic cancer
Yusuke Uchinami, Takahiro Kanehira, Yoshihiro Fujita, Naoki Miyamoto, Kohei Yokokawa, Fuki Koizumi, Motoyasu Shido, Shuhei Takahashi, Manami Otsuka, Koichi Yasuda, Hiroshi Taguchi, Keiji Nakazato, Keiji Kobashi, Norio Katoh, Hidefumi Aoyama
Clinical and Translational Radiation Oncology, 39, 100576, 100576, Elsevier BV, Mar. 2023, [Peer-reviewed]
Scientific journal - Study of hepatic toxicity in small liver tumors after photon or proton therapy based on factors predicting the benefits of proton.
Yusuke Uchinami, Norio Katoh, Daisuke Abo, Ryo Morita, Hiroshi Taguchi, Yoshihiro Fujita, Takahiro Kanehira, Ryusuke Suzuki, Naoki Miyamoto, Seishin Takao, Taeko Matsuura, Takuya Sho, Koji Ogawa, Tatsuya Orimo, Tatsuhiko Kakisaka, Keiji Kobashi, Hidefumi Aoyama
The British journal of radiology, 96, 1144, 20220720, 20220720, 12 Jan. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: In a previous study of hepatic toxicity, the following three factors were identified to predict the benefits of proton beam therapy (PBT) for hepatocellular carcinomas (HCC) with a maximum diameter of ≤5 cm and Child-pugh grade A (CP-A): number of tumors (one vs ≥2), the location of tumors (hepatic hilum or others), and the sum of the diameters of lesions. The aim of this study is to analyze the association between these three factors and hepatic toxicity. METHODS: We retrospectively reviewed patients of CP-A treated with PBT or photon stereotactic body radiotherapy (X-ray radiotherapy, XRT) for HCC ≤5 cm. For normal liver dose, the V5, V10, V20 (volumes receiving 5, 10, and 20 Gy at least), and the mean dose was evaluated. The albumin-bilirubin (ALBI) and CP score changes from the baseline were evaluated at 3 and 6 months after treatment. RESULTS: In 89 patients (XRT: 48, PBT: 41), those with two or three (2-3) predictive factors were higher normal liver doses than with zero or one (0-1) factor. In the PBT group, the ALBI score worsened more in patients with 2-3 factors than those with 0-1 factor, at 3 months (median 0.26 vs 0.02, p = 0.032) and at 6 months (median: 0.35 vs 0.10, p = 0.009). The ALBI score change in the XRT group and CP score change in either modality were not significantly different in the number of predictive factors. CONCLUSIONS: The predictive factor numbers predicted the ALBI score change in PBT but not in XRT. ADVANCES IN KNOWLEDGE: This study suggest that the number of predictive factors previously identified (0-1 vs 2-3) were significantly associated with dosimetric parameters of the normal liver in both modalities. In the proton group, the number of predictive factors was associated with a worsening ALBI score at 3 and 6 months, but these associations were not found in the photon SBRT group. - Deformed dose restoration to account for tumor deformation and position changes for adaptive proton therapy.
Koichi Miyazaki, Yusuke Fujii, Takahiro Yamada, Takahiro Kanehira, Naoki Miyamoto, Taeko Matsuura, Koichi Yasuda, Yusuke Uchinami, Manami Otsuka, Hidefumi Aoyama, Seishin Takao
Medical physics, 50, 2, 675, 687, 11 Dec. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Online adaptation during intensity-modulated proton therapy (IMPT) can minimize the effect of inter-fractional anatomical changes, but remains challenging because of the complex workflow. One approach for fast and automated online IMPT adaptation is dose restoration, which restores the initial dose distribution on the updated anatomy. However, this method may fail in cases where tumor deformation or position changes occur. PURPOSE: To develop a fast and robust IMPT online adaptation method named "deformed dose restoration (DDR)" that can adjust for inter-fractional tumor deformation and position changes. METHODS: THE DDR METHOD COMPRISES TWO STEPS: : (1) calculation of the deformed dose distribution, and (2) restoration of the deformed dose distribution. First, the deformable image registration (DIR) between the initial clinical target volume (CTV) and the new CTV were performed to calculate the vector field. To ensure robustness for setup and range uncertainty and the ability to restore the deformed dose distribution, an expanded CTV-based registration to maintain the dose gradient outside the CTV was developed. The deformed dose distribution was obtained by applying the vector field to the initial dose distribution. Then, the voxel-by-voxel dose difference optimization was performed to calculate beam parameters that restore the deformed dose distribution on the updated anatomy. The optimization function was the sum of total dose differences and dose differences of each field to restore the initial dose overlap of each field. This method only requires target contouring, which eliminates the need for organs at risk (OARs) contouring. Six clinical cases wherein the tumor deformation and/or position changed on repeated CTs were selected. DDR feasibility was evaluated by comparing the results with those from three other strategies, namely, not adapted (continuing the initial plan), adapted by previous dose restoration, and fully optimized. RESULTS: In all cases, continuing the initial plan was largely distorted on the repeated CTs and the dose-volume histogram (DVH) metrics for the target were reduced due to the tumor deformation or position changes. On the other hand, DDR improved DVH metrics for the target to the same level as the initial dose distribution. Dose increase was seen for some OARs because tumor growth had reduced the relative distance between CTVs and OARs. Robustness evaluation for setup and range uncertainty (3 mm/3.5%) showed that deviation in DVH-bandwidth for CTV D95% from the initial plan was 0.4 ± 0.5% (Mean ± S.D.) for DDR. The calculation time was 8.1 ± 6.4 min. CONCLUSIONS: An online adaptation algorithm was developed that improved the treatment quality for inter-fractional anatomical changes and retained robustness for intra-fractional setup and range uncertainty. The main advantage of this method is that it only requires target contouring alone and saves the time for OARs contouring. The fast and robust adaptation method for tumor deformation and position changes described here can reduce the need for offline adaptation and improve treatment efficiency. This article is protected by copyright. All rights reserved. - Technical Note: Performance evaluation of volumetric imaging based on motion modeling by principal component analysis
Suzuka Asano, Keishi Oseki, Seishin Takao, Koichi Miyazaki, Kohei Yokokawa, Taeko Matsuura, Hiroshi Taguchi, Norio Katoh, Hidefumi Aoyama, Kikuo Umegaki, Naoki Miyamoto
Medical Physics, Wiley, 03 Dec. 2022, [Peer-reviewed], [Corresponding author]
Scientific journal - Detailed analysis of failure patterns using deformable image registration in hypopharyngeal cancer patients treated with sequential boost intensity-modulated radiotherapy.
Manami Otsuka, Koichi Yasuda, Yusuke Uchinami, Nayuta Tsushima, Takayoshi Suzuki, Satoshi Kano, Ryusuke Suzuki, Naoki Miyamoto, Hideki Minatogawa, Yasuhiro Dekura, Takashi Mori, Kentaro Nishioka, Jun Taguchi, Yasushi Shimizu, Norio Katoh, Akihiro Homma, Hidefumi Aoyama
Journal of medical imaging and radiation oncology, 67, 1, 98, 110, 14 Nov. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, INTRODUCTION: Sequential boost intensity-modulated radiotherapy (SQB-IMRT) uses two different planning CTs (pCTs) and treatment plans. SQB-IMRT is a form of adaptive radiotherapy that allows for responses to changes in the shape of the tumour and organs at risk (OAR). On the other hand, dose accumulation with the two plans can be difficult to evaluate. The purpose of this study was to analyse patterns of loco-regional failure using deformable image registration (DIR) in hypopharyngeal cancer patients treated with SQB-IMRT. METHODS: Between 2013 and 2019, 102 patients with hypopharyngeal cancer were treated with definitive SQB-IMRT at our institution. Dose accumulation with the 1st and 2nd plans was performed, and the dose to the loco-regional recurrent tumour volume was calculated using the DIR workflow. Failure was classified as follows: (i) in-field (≥95% of the recurrent tumour volume received 95% of the prescribed dose); (ii) marginal (20-95%); or (iii) out-of-field (<20%). RESULTS: After a median follow-up period of 25 months, loco-regional failure occurred in 34 patients. Dose-volume histogram analysis showed that all loco-regional failures occurred in the field within 95% of the prescribed dose, with no marginal or out-of-field recurrences observed. CONCLUSION: The dosimetric analysis using DIR showed that all loco-regional failures were within the high-dose region. More aggressive treatment may be required for gross tumours. - Injectable Fiducial Marker for Image-Guided Radiation Therapy Based on Gold Nanoparticles and a Body Temperature-Activated Gel-Forming System
Haoran Liu, Naoki Miyamoto, Mai Thanh Nguyen, Hiroki Shirato, Tetsu Yonezawa
ACS Applied Bio Materials, 08 Sep. 2022, [Peer-reviewed], [International Magazine]
Scientific journal - Ligand release from silicon phthalocyanine dyes triggered by X-ray irradiation.
Hideo Takakura, Shino Matsuhiro, Osamu Inanami, Masato Kobayashi, Kenichiro Saita, Masaki Yamashita, Kohei Nakajima, Motofumi Suzuki, Naoki Miyamoto, Tetsuya Taketsugu, Mikako Ogawa
Organic & biomolecular chemistry, 16 Aug. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Ligand release from silicon phthalocyanine (SiPc) dyes triggered by near-infrared (NIR) light is a key photochemical reaction involving caged compounds based on SiPc. Although NIR light is relatively permeable compared with visible light, this light can be attenuated by tissue absorption and scattering; therefore, using light to induce photochemical reactions deep inside the body is difficult. Herein, because X-rays are highly permeable and can produce radicals through the radiolysis of water, we investigated whether the axial ligands of SiPcs can be cleaved using X-ray irradiation. SiPcs with different axial ligands (alkoxy, siloxy, oxycarbonyl, and phenoxy groups) were irradiated with X-rays under hypoxic conditions. We found that the axial ligands were cleaved via reactions with hydrated electrons (e-aq), not OH radicals, generated from water in response to X-ray irradiation, and SiPc with alkoxy groups exhibited the highest cleavage efficiency. A quantitative investigation revealed that X-ray-induced axial ligand cleavage proceeds via a radical chain reaction. The reaction is expected to be applicable to the molecular design of X-ray-activatable functional molecules in the future. - A study on predicting cases that would benefit from proton beam therapy in primary liver tumors of less than or equal to 5 cm based on the estimated incidence of hepatic toxicity
Yusuke Uchinami, Norio Katoh, Ryusuke Suzuki, Takahiro Kanehira, Masaya Tamura, Seishin Takao, Taeko Matsuura, Naoki Miyamoto, Yoshihiro Fujita, Fuki Koizumi, Hiroshi Taguchi, Koichi Yasuda, Kentaro Nishioka, Isao Yokota, Keiji Kobashi, Hidefumi Aoyama
Clinical and Translational Radiation Oncology, 35, 70, 75, Elsevier BV, Jul. 2022, [Peer-reviewed]
Scientific journal - Preparation of Biopex-Supported Gold Nanoparticles as Potential Fiducial Markers for Image-Guided Radiation Therapy.
Kai Ikeda, Haoran Liu, Naoki Miyamoto, Mai Thanh Nguyen, Hiroki Shirato, Tetsu Yonezawa
ACS applied bio materials, 5, 3, 1259, 1266, 21 Mar. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Image-guided radiation therapy (IGRT) has emerged as a promising technique for cancer treatment to improve radiation precision and accuracy, thereby reducing the treatment toxicity and optimizing therapeutic efficacy. In IGRT, fiducial markers are required to be inserted near the tumor to get the spatial information of the tumor. Currently used metal fiducial markers with large sizes would be highly invasive; therefore, it is critical to develop minimally invasive alternatives to these markers. In this work, an injectable marker based on Biopex-supported Au NPs with adequate radio-opacity for X-ray visualization was developed. Biopex can function as a substrate for the growth of Au NPs and avoid excessive reaction-induced aggregation and precipitation. The self-curing property of Biopex prevents the leakage and elimination of isolated Au NPs, enabling long-term X-ray observation and radiotherapy. The effect of Biopex amount, gold precursor concentration, and reaction time were evaluated. The visibility of samples prepared by the optimized formula was also examined. The developed Biopex-Au NPs could be injected through a 21 G needle and exhibit great visibility in the X-ray visualization test, showing great potential as a fiducial marker for image-guided radiation therapy. - Green and effective synthesis of gold nanoparticles as an injectable fiducial marker for real-time image gated proton therapy
Haoran Liu, Naoki Miyamoto, Mai Thanh Nguyen, Hiroki Shirato, Tetsu Yonezawa
Materials Advances, Royal Society of Chemistry ({RSC}), 2022, [Peer-reviewed]
Scientific journal - Impact of a spatially dependent dose delivery time structure on the biological effectiveness of scanning proton therapy.
Koki Kasamatsu, Sodai Tanaka, Koichi Miyazaki, Seishin Takao, Naoki Miyamoto, Shusuke Hirayama, Kentaro Nishioka, Takayuki Hashimoto, Hidefumi Aoyama, Kikuo Umegaki, Taeko Matsuura
Medical physics, 49, 1, 702, 713, Jan. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: In the scanning beam delivery of protons, different portions of the target are irradiated with different linear energy transfer protons with various time intervals and irradiation times. This research aimed to evaluate the spatially dependent biological effectiveness of protracted irradiation in scanning proton therapy. METHODS: One and two parallel opposed fields plans were created in water phantom with the prescribed dose of 2 Gy. Three scenarios (instantaneous, continuous, and layered scans) were used with the corresponding beam delivery models. The biological dose (physical dose × relative biological effectiveness) was calculated using the linear quadratic model and the theory of dual radiation action to quantitatively evaluate the dose delivery time effect. In addition, simulations using clinical plans (postoperative seminoma and prostate tumor cases) were conducted to assess the impact of the effects on the dose volume histogram parameters and homogeneity coefficient (HC) in targets. RESULTS: In a single-field plan of water phantom, when the treatment time was 19 min, the layered-scan scenario showed a decrease of <0.2% (almost 3.3%) in the biological dose from the plan on the distal (proximal) side because of the high (low) dose rate. This is in contrast to the continuous scenario, where the biological dose was almost uniformly decreased over the target by approximately 3.3%. The simulation with clinical geometry showed that the decrease rates in D99% were 0.9% and 1.5% for every 10 min of treatment time prolongation for postoperative seminoma and prostate tumor cases, respectively, whereas the increase rates in HC were 0.7% and 0.2%. CONCLUSIONS: In protracted irradiation in scanning proton therapy, the spatially dependent dose delivery time structure in scanning beam delivery can be an important factor for accurate evaluation of biological effectiveness. - Prediction of target position from multiple fiducial markers by partial least squares regression in real-time tumor-tracking radiation therapy.
Kanako Ukon, Yohei Arai, Seishin Takao, Taeko Matsuura, Masayori Ishikawa, Hiroki Shirato, Shinichi Shimizu, Kikuo Umegaki, Naoki Miyamoto
Journal of radiation research, 62, 5, 926, 933, 13 Sep. 2021, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, The purpose of this work is to show the usefulness of a prediction method of tumor location based on partial least squares regression (PLSR) using multiple fiducial markers. The trajectory data of respiratory motion of four internal fiducial markers inserted in lungs were used for the analysis. The position of one of the four markers was assumed to be the tumor position and was predicted by other three fiducial markers. Regression coefficients for prediction of the position of the tumor-assumed marker from the fiducial markers' positions is derived by PLSR. The tracking error and the gating error were evaluated assuming two possible variations. First, the variation of the position definition of the tumor and the markers on treatment planning computed tomograhy (CT) images. Second, the intra-fractional anatomical variation which leads the distance change between the tumor and markers during the course of treatment. For comparison, rigid predictions and ordinally multiple linear regression (MLR) predictions were also evaluated. The tracking and gating errors of PLSR prediction were smaller than those of other prediction methods. Ninety-fifth percentile of tracking/gating error in all trials were 3.7/4.1 mm, respectively in PLSR prediction for superior-inferior direction. The results suggested that PLSR prediction was robust to variations, and clinically applicable accuracy could be achievable for targeting tumors. - First experimental results of gated proton imaging using x-ray fluoroscopy to detect a fiducial marker.
Sodai Tanaka, Naoki Miyamoto, Yuto Matsuo, Takaaki Yoshimura, Seishin Takao, Taeko Matsuura
Physics in medicine and biology, 66, 18, 09 Sep. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, Increasing numbers of proton imaging research studies are being conducted for accurate proton range determination in proton therapy treatment planning. However, there is no proton imaging system that deals with motion artifacts. In this study, a gated proton imaging system was developed and the first experimental results of proton radiography (pRG) were obtained for a moving object without motion artifacts. A motion management system using dual x-ray fluoroscopy for detecting a spherical gold fiducial marker was introduced and the proton beam was gated in accordance with the motion of the object. To demonstrate the performance of the gated proton imaging system, gated pRG images of a moving phantom were acquired experimentally, and the motion artifacts clearly were diminished. Also, the factors causing image deteriorations were evaluated focusing on the new gating system developed here, and the main factor was identified as the latency (with a maximum value of 93 ms) between the ideal gating signal according to the actual marker position and the actual gating signal. The possible deterioration due to the latency of the proton imaging system and proton beam irradiation was small owing to appropriate setting of the time structure. - Real-time CT image generation based on voxel-by-voxel modeling of internal deformation by utilizing the displacement of fiducial markers.
Risa Hayashi, Koichi Miyazaki, Seishin Takao, Kohei Yokokawa, Sodai Tanaka, Taeko Matsuura, Hiroshi Taguchi, Norio Katoh, Shinichi Shimizu, Kikuo Umegaki, Naoki Miyamoto
Medical physics, 48, 9, 5311, 5326, Sep. 2021, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, PURPOSE: To show the feasibility of real-time CT image generation technique utilizing internal fiducial markers that facilitate the evaluation of internal deformation. METHODS: In the proposed method, a linear regression model that can derive internal deformation from the displacement of fiducial markers is built for each voxel in the training process before the treatment session. Marker displacement and internal deformation are derived from the four-dimensional computed tomography (4DCT) dataset. In the treatment session, the three-dimensional deformation vector field is derived according to the marker displacement, which is monitored by the real-time imaging system. The whole CT image can be synthesized by deforming the reference CT image with a deformation vector field in real-time. To show the feasibility of the technique, image synthesis accuracy and tumor localization accuracy were evaluated using the dataset generated by extended NURBS-Based Cardiac-Torso (XCAT) phantom and clinical 4DCT datasets from six patients, containing 10 CT datasets each. In the validation with XCAT phantom, motion range of the tumor in training data and validation data were about 10 and 15 mm, respectively, so as to simulate motion variation between 4DCT acquisition and treatment session. In the validation with patient 4DCT dataset, eight CT datasets from the 4DCT dataset were used in the training process. Two excluded inhale CT datasets can be regarded as the datasets with large deformations more than training dataset. CT images were generated for each respiratory phase using the corresponding marker displacement. Root mean squared error (RMSE), normalized RMSE (NRMSE), and structural similarity index measure (SSIM) between the original CT images and the synthesized CT images were evaluated as the quantitative indices of the accuracy of image synthesis. The accuracy of tumor localization was also evaluated. RESULTS: In the validation with XCAT phantom, the mean NRMSE, SSIM, and three-dimensional tumor localization error were 7.5 ± 1.1%, 0.95 ± 0.02, and 0.4 ± 0.3 mm, respectively. In the validation with patient 4DCT dataset, the mean RMSE, NRMSE, SSIM, and three-dimensional tumor localization error in six patients were 73.7 ± 19.6 HU, 9.2 ± 2.6%, 0.88 ± 0.04, and 0.8 ± 0.6 mm, respectively. These results suggest that the accuracy of the proposed technique is adequate when the respiratory motion is within the range of the training dataset. In the evaluation with a marker displacement larger than that of the training dataset, the mean RMSE, NRMSE, and tumor localization error were about 100 HU, 13%, and <2.0 mm, respectively, except for one case having large motion variation. The performance of the proposed method was similar to those of previous studies. Processing time to generate the volumetric image was <100 ms. CONCLUSION: We have shown the feasibility of the real-time CT image generation technique for volumetric imaging. - Eribulin improves tumor oxygenation demonstrated by 18F-DiFA hypoxia imaging, leading to radio-sensitization in human cancer xenograft models.
Tomoki Bo, Hironobu Yasui, Tohru Shiga, Yuki Shibata, Masaki Fujimoto, Motofumi Suzuki, Kei Higashikawa, Naoki Miyamoto, Osamu Inanami, Yuji Kuge
European journal of nuclear medicine and molecular imaging, 49, 3, 821, 833, 01 Sep. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: Eribulin, an inhibitor of microtubule dynamics, is known to show antitumor effects through its remodeling activity in the tumor vasculature. However, the extent to which the improvement of tumor hypoxia by eribulin affects radio-sensitivity remains unclear. We utilized 1-(2,2-dihydroxymethyl-3-18F-fluoropropyl)-2-nitroimidazole (18F-DiFA), a new PET probe for hypoxia, to investigate the effects of eribulin on tumor hypoxia and evaluate the radio-sensitivity during eribulin treatment. METHODS: Mice bearing human breast cancer MDA-MB-231 cells or human lung cancer NCI-H1975 cells were administered a single dose of eribulin. After administration, mice were injected with 18F-DiFA and pimonidazole, and tumor hypoxia regions were analyzed. For the group that received combined treatment with radiation, 18F-DiFA PET/CT imaging was performed before tumors were locally X-irradiated. Tumor size was measured every other day after irradiation. RESULTS: Eribulin significantly reduced 18F-DiFA accumulation levels in a dose-dependent manner. Furthermore, the reduction in 18F-DiFA accumulation levels by eribulin was most significant 7 days after treatment. These results were also supported by reduction of the pimonidazole-positive hypoxic region. The combined treatment showed significant retardation of tumor growth in comparison with the control, radiation-alone, and drug-alone groups. Importantly, tumor growth after irradiation was inversely correlated with 18F-DiFA accumulation. CONCLUSION: These results demonstrated that 18F-DiFA PET/CT clearly detected eribulin-induced tumor oxygenation and that eribulin efficiently enhanced the antitumor activity of radiation by improving tumor oxygenation. - Treatment outcomes of stereotactic body radiation therapy using a real-time tumor-tracking radiotherapy system for hepatocellular carcinomas.
Yusuke Uchinami, Norio Katoh, Daisuke Abo, Hiroshi Taguchi, Koichi Yasuda, Kentaro Nishioka, Takeshi Soyama, Ryo Morita, Naoki Miyamoto, Ryusuke Suzuki, Takuya Sho, Masato Nakai, Koji Ogawa, Tatsuhiko Kakisaka, Tatsuya Orimo, Toshiya Kamiyama, Shinichi Shimizu, Hidefumi Aoyama
Hepatology research : the official journal of the Japan Society of Hepatology, 51, 8, 870, 879, Aug. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, AIM: To report the outcomes of stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system for hepatocellular carcinoma patients. METHODS: From January 2005 to July 2018, 63 patients with 74 lesions with a maximum diameter ≤52 mm were treated by stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system. No patient with a Child-Pugh Score ≥9 was included, and 85.6% had a score of 5 or 6. Using the biological effective dose (BED) with an α/β ratio of 10 (BED10 ), the median dose in BED10 at the reference point was 76.8 Gy (range 60-122.5 Gy). Overall survival (OS) and local control rates were assessed using the Kaplan-Meier method. RESULTS: With a median follow-up period of 24.6 months (range 0.9-118.4 months), the 1-year and 2-year OS rates were 86.8% (95% confidence interval [95% CI] 75.8-93.3) and 71.1% (57.8-81.6), respectively. The 2-year OS was 89.6% in patients with the baseline modified albumin-bilirubin (mALBI) grade =1, and 61.7% in patients with grade ≥2a. In the multivariate analysis, the mALBI grade (=1 vs. ≥2a) was a significant factor for OS (p = 0.028, 95% CI 1.11-6.18). The 1-year and 2-year local control rates were 100% (100-100%) and 92.0% (77.5-97.5%). The local control rates were significantly higher in the BED10 ≥100 Gy group than in the BED10 <100 Gy group (2-year 100% vs. 86.5%, p = 0.049) at the reference point. CONCLUSION: This retrospective study of stereotactic body radiotherapy using real-time tumor-tracking radiotherapy for hepatocellular carcinoma showed favorable outcomes with lower incidence of toxicities, especially in patients treated with BED10 ≥100 Gy to the reference point. - Validation of dose distribution for liver tumors treated with real-time-image gated spot-scanning proton therapy by log data based dose reconstruction.
Takahiro Yamada, Seishin Takao, Hidenori Koyano, Hideaki Nihongi, Yusuke Fujii, Shusuke Hirayama, Naoki Miyamoto, Taeko Matsuura, Kikuo Umegaki, Norio Katoh, Isao Yokota, Hiroki Shirato, Shinichi Shimizu
Journal of radiation research, 62, 4, 626, 633, 10 Jul. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, In spot scanning proton therapy (SSPT), the spot position relative to the target may fluctuate through tumor motion even when gating the radiation by utilizing a fiducial marker. We have established a procedure that evaluates the delivered dose distribution by utilizing log data on tumor motion and spot information. The purpose of this study is to show the reliability of the dose distributions for liver tumors treated with real-time-image gated SSPT (RGPT). In the evaluation procedure, the delivered spot information and the marker position are synchronized on the basis of log data on the timing of the spot irradiation and fluoroscopic X-ray irradiation. Then a treatment planning system reconstructs the delivered dose distribution. Dose distributions accumulated for all fractions were reconstructed for eight liver cases. The log data were acquired in all 168 fractions for all eight cases. The evaluation was performed for the values of maximum dose, minimum dose, D99, and D5-D95 for the clinical target volumes (CTVs) and mean liver dose (MLD) scaled by the prescribed dose. These dosimetric parameters were statistically compared between the planned dose distribution and the reconstructed dose distribution. The mean difference of the maximum dose was 1.3% (95% confidence interval [CI]: 0.6%-2.1%). Regarding the minimum dose, the mean difference was 0.1% (95% CI: -0.5%-0.7%). The mean differences of D99, D5-D95 and MLD were below 1%. The reliability of dose distributions for liver tumors treated with RGPT-SSPT was shown by the evaluation of the accumulated dose distributions. - Fundamental study on quality assurance (QA) procedures for a real-time tumor tracking radiotherapy (RTRT) system from the viewpoint of imaging devices.
Suguru Kimura, Naoki Miyamoto, Kenneth L Sutherland, Ryusuke Suzuki, Hiroki Shirato, Masayori Ishikawa
Journal of applied clinical medical physics, 22, 7, 165, 176, Jul. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: The real-time tumor tracking radiotherapy (RTRT) system requires periodic quality assurance (QA) and quality control. The goal of this study is to propose QA procedures from the viewpoint of imaging devices in the RTRT system. METHODS: Tracking by the RTRT system (equips two sets of colored image intensifiers (colored I.I.s) fluoroscopy units) for the moving gold-marker (diameter 2.0 mm) in a rotating phantom were performed under various X-ray conditions. To analyze the relationship between fluoroscopic image quality and precision of gold marker coordinate calculation, the standard deviation of the 3D coordinate (σ3D [mm]) of the gold marker, the mean of the pattern recognition score (PRS) and the standard deviation of the distance between rays (DBR) (σDBR [mm]) were evaluated. RESULTS: When tracking with speed of 10-60 mm/s, σDBR increased, though the mean PRS did not change significantly (p>0.05). On the contrary, the mean PRS increased depending on the integral noise equivalent quanta (∫NEQ) that is an indicator of image quality calculated from the modulation transfer function (MTF) as an indicator of spatial resolution and the noise power spectrum (NPS) as an indicator of noise characteristic. CONCLUSION: The indicators of NEQ, MTF, and NPS were useful for managing the tracking accuracy of the RTRT system. We propose observing the change of these indicators as additional QA procedures for each imaging device from the commissioning baseline. - Clinical practice vs. state-of-the-art research and future visions: Report on the 4D treatment planning workshop for particle therapy - Edition 2018 and 2019.
Katarzyna Czerska, Frank Emert, Renata Kopec, Katja Langen, Jamie R McClelland, Arturs Meijers, Naoki Miyamoto, Marco Riboldi, Shinichi Shimizu, Toshiyuki Terunuma, Wei Zou, Antje Knopf, Antoni Rucinski
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 82, 54, 63, Feb. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, The 4D Treatment Planning Workshop for Particle Therapy, a workshop dedicated to the treatment of moving targets with scanned particle beams, started in 2009 and since then has been organized annually. The mission of the workshop is to create an informal ground for clinical medical physicists, medical physics researchers and medical doctors interested in the development of the 4D technology, protocols and their translation into clinical practice. The 10th and 11th editions of the workshop took place in Sapporo, Japan in 2018 and Krakow, Poland in 2019, respectively. This review report from the Sapporo and Krakow workshops is structured in two parts, according to the workshop programs. The first part comprises clinicians and physicists review of the status of 4D clinical implementations. Corresponding talks were given by speakers from five centers around the world: Maastro Clinic (The Netherlands), University Medical Center Groningen (The Netherlands), MD Anderson Cancer Center (United States), University of Pennsylvania (United States) and The Proton Beam Therapy Center of Hokkaido University Hospital (Japan). The second part is dedicated to novelties in 4D research, i.e. motion modelling, artificial intelligence and new technologies which are currently being investigated in the radiotherapy field. - The impact of dose delivery time on biological effectiveness in proton irradiation with various biological parameters.
Koki Kasamatsu, Taeko Matsuura, Sodai Tanaka, Seishin Takao, Naoki Miyamoto, Jin-Min Nam, Hiroki Shirato, Shinichi Shimizu, Kikuo Umegaki
Medical physics, 47, 9, 4644, 4655, 11 Jul. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: The purpose of this study is to evaluate the sub-lethal damage (SLD) repair effect in prolonged proton irradiation using the biophysical model with various cell-specific parameters of (α/β)x and T1/2 (repair half time). At present, most of the model-based studies on protons have focused on acute radiation, neglecting the reduction in biological effectiveness due to SLD repair during the delivery of radiation. Nevertheless, the dose-rate dependency of biological effectiveness may become more important as advanced treatment techniques, such as hypofractionation and respiratory gating, come into clinical practice, as these techniques sometimes require long treatment times. Also, while previous research using the biophysical model revealed a large repair effect with a high physical dose, the dependence of the repair effect on cell-specific parameters has not been evaluated systematically. METHODS: Biological dose (relative biological effectiveness (RBE) × physical dose) calculation with repair included was carried out using the linear energy transfer (LET)-dependent linear-quadratic (LQ) model combined with the theory of dual radiation action (TDRA). First, we extended the dose protraction factor in the LQ model for the arbitrary number of different LET proton irradiations delivered sequentially with arbitrary time lags, referring to the TDRA. Using the LQ model, the decrease in biological dose due to SLD repair was systematically evaluated for spread-out Bragg peak (SOBP) irradiation in a water phantom with the possible ranges of both (α/β)x and repair parameters ((α/β)x = 1-15 Gy, T1/2 = 0-90 min). Then, to consider more realistic irradiation conditions, clinical cases of prostate, liver, and lung tumors were examined with the cell-specific parameters for each tumor obtained from the literature. Biological D99% and biological dose homogeneity coefficient (HC) were calculated for the clinical target volumes (CTVs), assuming dose-rate structures with a total irradiation time of 0-60 min. RESULTS: The differences in the cell-specific parameters resulted in considerable variation in the repair effect. The biological dose reduction found at the center of the SOBP with 30 min of continuous irradiation varied from 1.13% to 14.4% with a T1/2 range of 1-90 min when (α/β)x is fixed as 10 Gy. It varied from 2.3% to 6.8% with an (α/β)x range of 1-15 Gy for a fixed value of T1/2 = 30 min. The decrease in biological D99% per 10 min was 2.6, 1.2, and 3.0% for the prostate, liver, and lung tumor cases, respectively. The value of the biological D99% reduction was neither in the order of (α/β)x nor prescribed dose, but both comparably contributed to the repair effect. The variation of HC was within the range of 0.5% for all cases; therefore, the dose distribution was not distorted. CONCLUSION: The reduction in biological dose caused by the SLD repair largely depends on the cell-specific parameters in addition to the physical dose. The parameters should be considered carefully in the evaluation of the repair effect in prolonged proton irradiation. - Difference in LET-based biological doses between IMPT optimization techniques: Robust and PTV-based optimizations.
Shusuke Hirayama, Taeko Matsuura, Koichi Yasuda, Seishin Takao, Takaaki Fujii, Naoki Miyamoto, Kikuo Umegaki, Shinichi Shimizu
Journal of applied clinical medical physics, 21, 4, 42, 50, Apr. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: While a large amount of experimental data suggest that the proton relative biological effectiveness (RBE) varies with both physical and biological parameters, current commercial treatment planning systems (TPS) use the constant RBE instead of variable RBE models, neglecting the dependence of RBE on the linear energy transfer (LET). To conduct as accurate a clinical evaluation as possible in this circumstance, it is desirable that the dosimetric parameters derived by TPS ( D RBE = 1.1 ) are close to the "true" values derived with the variable RBE models ( D v RBE ). As such, in this study, the closeness of D RBE = 1.1 to D v RBE was compared between planning target volume (PTV)-based and robust plans. METHODS: Intensity-modulated proton therapy (IMPT) treatment plans for two Radiation Therapy Oncology Group (RTOG) phantom cases and four nasopharyngeal cases were created using the PTV-based and robust optimizations, under the assumption of a constant RBE of 1.1. First, the physical dose and dose-averaged LET (LETd ) distributions were obtained using the analytical calculation method, based on the pencil beam algorithm. Next, D v RBE was calculated using three different RBE models. The deviation of D v RBE from D RBE = 1.1 was evaluated with D99 and Dmax , which have been used as the evaluation indices for clinical target volume (CTV) and organs at risk (OARs), respectively. The influence of the distance between the OAR and CTV on the results was also investigated. As a measure of distance, the closest distance and the overlapped volume histogram were used for the RTOG phantom and nasopharyngeal cases, respectively. RESULTS: As for the OAR, the deviations of D max v RBE from D max RBE = 1.1 were always smaller in robust plans than in PTV-based plans in all RBE models. The deviation would tend to increase as the OAR was located closer to the CTV in both optimization techniques. As for the CTV, the deviations of D 99 v RBE from D 99 RBE = 1.1 were comparable between the two optimization techniques, regardless of the distance between the CTV and the OAR. CONCLUSION: Robust optimization was found to be more favorable than PTV-based optimization in that the results presented by TPS were closer to the "true" values and that the clinical evaluation based on TPS was more reliable. - Dynamic gating window technique for the reduction of dosimetric error in respiratory-gated spot-scanning particle therapy: An initial phantom study using patient tumor trajectory data.
Naoki Miyamoto, Kouhei Yokokawa, Seishin Takao, Taeko Matsuura, Sodai Tanaka, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki
Journal of applied clinical medical physics, 21, 4, 13, 21, 18 Feb. 2020, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal, Spot-scanning particle therapy possesses advantages, such as high conformity to the target and efficient energy utilization compared with those of the passive scattering irradiation technique. However, this irradiation technique is sensitive to target motion. In the current clinical situation, some motion management techniques, such as respiratory-gated irradiation, which uses an external or internal surrogate, have been clinically applied. In surrogate-based gating, the size of the gating window is fixed during the treatment in the current treatment system. In this study, we propose a dynamic gating window technique, which optimizes the size of gating window for each spot by considering a possible dosimetric error. The effectiveness of the dynamic gating window technique was evaluated by simulating irradiation using a moving target in a water phantom. In dosimetric characteristics comparison, the dynamic gating window technique exhibited better performance in all evaluation volumes with different effective depths compared with that of the fixed gate approach. The variation of dosimetric characteristics according to the target depth was small in dynamic gate compared to fixed gate. These results suggest that the dynamic gating window technique can maintain an acceptable dose distribution regardless of the target depth. The overall gating efficiency of the dynamic gate was approximately equal or greater than that of the fixed gating window. In dynamic gate, as the target depth becomes shallower, the gating efficiency will be reduced, although dosimetric characteristics will be maintained regardless of the target depth. The results of this study suggest that the proposed gating technique may potentially improve the dose distribution. However, additional evaluations should be undertaken in the future to determine clinical applicability by assuming the specifications of the treatment system and clinical situation. - The urethral position may shift due to urethral catheter placement in the treatment planning for prostate radiation therapy.
Yasuhiro Dekura, Kentaro Nishioka, Takayuki Hashimoto, Naoki Miyamoto, Ryusuke Suzuki, Takaaki Yoshimura, Ryuji Matsumoto, Takahiro Osawa, Takashige Abe, Yoichi M Ito, Nobuo Shinohara, Hiroki Shirato, Shinichi Shimizu
Radiation oncology (London, England), 14, 1, 226, 226, 12 Dec. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: To determine the best method to contour the planning organ at risk volume (PRV) for the urethra, this study aimed to investigate the displacement of a Foley catheter in the urethra with a soft and thin guide-wire. METHODS: For each patient, the study used two sets of computed tomography (CT) images for radiation treatment planning (RT-CT): (1) set with a Foley urethral catheter (4.0 mm diameter) plus a guide-wire (0.46 mm diameter) in the first RT-CT and (2) set with a guide-wire alone in the second CT recorded 2 min after the first RT-CT. Using three fiducial markers in the prostate for image fusion, the displacement between the catheter and the guide-wire in the prostatic urethra was calculated. In 155 consecutive patients treated between 2011 and 2017, 5531 slices of RT-CT were evaluated. RESULTS: Assuming that ≥3.0 mm of difference between the catheter and the guide-wire position was a significant displacement, the urethra with the catheter was displaced significantly from the urethra with the guide-wire alone in > 20% of the RT-CT slices in 23.2% (36/155) of the patients. The number of patients who showed ≥3.0 mm anterior displacement with the catheter in ≥20% RT-CT slices was significantly larger at the superior segment (38/155) than at the middle (14/155) and inferior segments (18/155) of the prostatic urethra (p < 0.0167). CONCLUSIONS: The urethral position with a Foley catheter is different from the urethral position with a thin and soft guide-wire in a significant proportion of the patients. This should be taken into account for the PRV of the urethra to ensure precise radiotherapy such as in urethra-sparing radiotherapy. - OC-078: Development of Gated Proton Imaging System for Moving Target
S. Tanaka, N. Miyamoto, T. Nishio, T. Yoshimura, S. Takao, Y. Matsuo, S. Shimizu, H. Shirato, T. Matsuura
Radiotherapy and Oncology, 141, S32, S33, Elsevier BV, Dec. 2019
Scientific journal - Phase Extraction from Single Interferogram Including Closed-Fringe Using Deep Learning
Daichi Kando, Satoshi Tomioka, Naoki Miyamoto, Ryosuke Ueda
APPLIED SCIENCES-BASEL, 9, 17, Sep. 2019, [Peer-reviewed]
English, Scientific journal - The Potential Benefit of Adaptive Intensity Modulated Proton Therapy in Nasopharyngeal Carcinoma: Planning Comparison Study
H. Minatogawa, K. Yasuda, T. Matsuura, R. Onimaru, T. Yoshimura, S. Takao, Y. Matsuo, Y. Dekura, R. Suzuki, M. Tamura, N. Miyamoto, S. Shimizu, H. Shirato
International Journal of Radiation Oncology*Biology*Physics, 105, 1, E394, E394, Elsevier BV, Sep. 2019
Scientific journal - Percutaneous insertion of hepatic fiducial true-spherical markers for real-time adaptive radiotherapy.
Morita R, Abo D, Sakuhara Y, Soyama T, Katoh N, Miyamoto N, Uchinami Y, Shimizu S, Shirato H, Kudo K
Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy, 29, 6, 1, 10, Sep. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Purpose: This study evaluated the success rate and complications of percutaneous implantation of hepatic fiducial true-spherical gold markers for real-time adaptive radiotherapy (RAR), which constitutes real-time image-guided radiotherapy with gating.Material and methods: We retrospectively evaluated 100 patients who underwent 116 percutaneous intrahepatic implantations of 2-mm-diameter, spherical, gold fiducial markers before RAR from 1999 to 2016, with Seldinger's method. We defined technical success as marker placement at the intended liver parenchyma, without mispositioning, and clinical success as successful tracking of the gold marker and completion of planned RAR. Complications related to marker placement were assessed.Results: The technical success rate for true-spherical gold marker implantation was 92.2% (107/116). Nine of 116 markers migrated (intra-procedurally in seven patients, delayed in two patients). Migration out of the liver (n = 4) or intrahepatic vessels (n = 5) occurred without complications; these markers were not retrieved. The clinical success rate was 100.0% (115/115). Abdominal pain occurred in 16 patients, fever and hemorrhage in seven patients each, and pneumothorax and nausea in one patient each. No major complications were encountered.Conclusions: Percutaneous transhepatic implantation of true-spherical gold markers for RAR is feasible and can be conducted with a high success rate and low complication rate. - Impact of organ motion on volumetric and dosimetric parameters in stomach lymphomas treated with intensity-modulated radiotherapy.
Uchinami Y, Suzuki R, Katoh N, Taguchi H, Yasuda K, Miyamoto N, Ito YM, Shimizu S, Shirato H
Journal of applied clinical medical physics, 20, 8, 78, 86, Aug. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: Interplay effects may influence dose distributions to a moving target when using dynamic delivery techniques such as intensity-modulated radiotherapy (IMRT). The aim of this study was to evaluate the impact of organ motion on volumetric and dosimetric parameters in stomach lymphomas treated with IMRT. METHODS: Ten patients who had been treated with IMRT for stomach lymphomas were enrolled. The clinical target volume (CTV) was contoured as the whole stomach. Considering interfractional uncertainty, the internal target volume (ITV) margin was uniformly 1.5 cm to the CTV and then modified based on the 4DCT images in case of the large respiratory motion. The planning target volume (PTV) was created by adding 5 mm to the ITV. The impact of organ motion on the volumetric and dosimetric parameters was evaluated retrospectively (4D simulation). The organ motion was reproduced by shifting the isocenter on the radiation treatment planning system. Several simulation plans were created to test the influence of the beam-on timing in the respiration cycle on the dose distribution. The homogeneity index (HI), volume percentage of stomach covered by the prescribed dose (Vp ), and D99 of the CTV were evaluated. RESULTS: The organ motion was the largest in the superior-inferior direction (10.1 ± 4.5 mm [average ± SD]). Stomach volume in each respiratory phase compared to the mean volume varied approximately within a ± 5% range in most of the patients. The PTV margin was sufficiently large to cover the CTV during the IMRT. There was a significant reduction in Vp and D99 but not in HI in the 4D simulation in free-breathing and multiple fractions compared to the clinically-used plan (P < 0.05) suggesting that interplay effects deteriorate the dose distribution. The absolute difference of D99 was less than 1% of the prescribed dose. CONCLUSIONS: There were significant interplay effects affecting the dose distribution in stomach IMRT. The magnitude of the dose reduction was small when patients were treated on free-breathing and multiple fractions. - Quantitative evaluation of image recognition performance of fiducial markers in real-time tumor-tracking radiation therapy.
Miyamoto N, Maeda K, Abo D, Morita R, Takao S, Matsuura T, Katoh N, Umegaki K, Shimizu S, Shirato H
Physica Medica, 65, 33, 36, Aug. 2019, [Peer-reviewed], [Lead author]
English, Scientific journal - 強度変調放射線治療中に皮下気腫をきたし,再検証を要した頭頸部癌患者の1例
湊川 英樹, 安田 耕一, 白土 博樹, 土屋 和彦, 鈴木 隆介, 宮本 直樹, 坂下 智博, 本間 明宏, 福田 諭
Japanese Journal of Radiology, 37, Suppl., 4, 4, (公社)日本医学放射線学会, Feb. 2019
Japanese - Desingularization of matrix equations employing hypersingular integrals in boundary element methods using double nodes
Satoshi Tomioka, Shusuke Nishiyama, Yutaka Matsumoto, Naoki Miyamoto
Engineering Analysis with Boundary Elements, 106, 493, 504, 2019, [Peer-reviewed]
English, Scientific journal - [Department of Medical Physics, Hokkaido University Hospital].
Ryusuke Suzuki, Naoki Miyamoto, Seishin Takao, Shinichi Shimizu
Igaku butsuri : Nihon Igaku Butsuri Gakkai kikanshi = Japanese journal of medical physics : an official journal of Japan Society of Medical Physics, 39, 2, 54, 56, 2019, [Domestic magazines]
Japanese, Scientific journal - Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo.
Yuki Shibata, Hironobu Yasui, Kei Higashikawa, Naoki Miyamoto, Yuji Kuge
PloS one, 14, 12, e0225931, 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, High concentrations of antioxidants in cancer cells are huge obstacle in cancer radiotherapy. Erastin was first discovered as an inducer of iron-dependent cell death called ferroptosis accompanied by antioxidant depletion caused by cystine glutamate antiporter inhibition. Therefore, treatment with erastin is expected to potentially enhance cellular radiosensitivity. In this study, we investigated the influence of treatment with erastin on the radiation efficiency against cancers. The clonogenic ability, glutathione peroxidase 4 (GPX4) expression, and glutathione concentration were evaluated using HeLa and NCI-H1975 adenocarcinoma cell lines treated with erastin and/or X-ray irradiation. For in vivo studies, NCI-H1975 cells were transplanted in the left shoulder of nude mice, and then radiosensitizing effect of erastin and glutathione concentration in the cancer were evaluated. Treatment with erastin induced ferroptosis and decreased the concentration of glutathione and GPX4 protein expression levels in the two tumor cell lines. Moreover, erastin enhanced X-ray irradiation-induced cell death in both human tumor cell lines. Furthermore, erastin treatment of a tumor-transplanted mouse model similarly demonstrated the radiosensitizing effect and decrease in intratumoral glutathione concentration in the in vitro study. In conclusion, our study demonstrated the radiosensitizing effect of erastin on two adenocarcinoma cell lines and the tumor xenograft model accompanied by glutathione depletion, indicating that ferroptosis inducers that reduce glutathione concentration could be applied as a novel cancer therapy in combination with radiotherapy. - 3D Transformation Matrix Calculation and Pixel Intensity Normalization for the Dual Focus Tracking System
Kenneth Sutherland, Toshiyuki Hamada, Masayori Ishikawa, Naoki Miyamoto, Masahiro Mizuta, Hiroyuki Date, Hiroki Shirato
Journal of Medical and Biological Engineering, 2019, [Peer-reviewed]
English, Scientific journal - Analysis of Beam Delivery Times and Dose Rates for the Treatment of Mobile Tumors Using Real Time Image Gated Spot-Scanning Proton Beam Therapy
S. Shimizu, T. Yoshimura, N. Katoh, T. Inoue, T. Hashimoto, K. Nishioka, S. Takao, T. Matsuura, N. Miyamoto, Y.M. Ito, K. Umegaki, H. Shirato
International Journal of Radiation Oncology*Biology*Physics, 102, 3, S182, S183, Elsevier BV, Nov. 2018
Scientific journal - Real-Time Tumor-Tracking Radiotherapy and General Stereotactic Body Radiotherapy for Adrenal Metastasis in Patients With Oligometastasis
Katoh N, Onishi H, Uchinami Y, Inoue T, Kuriyama K, Nishioka K, Shimizu S, Komiyama T, Miyamoto N, Shirato H
TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 17, 1533033818809983, 1533033818809983, Nov. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Precise local radiotherapy for adrenal metastasis can prolong the useful life of patients with oligometastasis. The aim of this retrospective, 2-center study was to establish the safety and effectiveness of real-time tumor-tracking radiotherapy and general stereotactic body radiotherapy in treating patients with adrenal metastatic tumors. MATERIALS AND METHODS: Thirteen lesions in 12 patients were treated with real-time tumor-tracking radiotherapy (48 Gy in 8 fractions over 2 weeks) and 8 lesions in 8 patients were treated with general stereotactic body radiotherapy (40-50 Gy in 5-8 fractions over 2 weeks or 60-70 Gy in 10 fractions over 2 weeks). Overall survival rates, local control rates, and adverse effects were analyzed. RESULTS: The actuarial overall survival rates for all patients at 1 and 2 years were 78.5% and 45.8%, respectively, with a median follow-up of 17.5 months, and the actuarial local control rates for all tumors at 1 and 2 years were 91.7% and 53.0%, respectively, with a median follow-up of 9 months. A complete local tumor response was obtained in 3 tumors treated by real-time tumor-tracking radiotherapy (lung adenocarcinomas with diameters of 35, 40, and 60 mm). There was a statistically significant difference in the local control between the groups treated by real-time tumor-tracking radiotherapy (100% at 1 year) and general stereotactic body radiotherapy (50% at 1 year; P < .001). No late adverse reactions at Grade 2 or higher were reported for either treatment group. CONCLUSIONS: This study showed that although both treatments are safe and effective, the real-time tumor-tracking radiotherapy is more effective than general stereotactic body radiotherapy in local control for adrenal metastasis. - Determination of the urethra position for accurate radiation therapy of prostate cancers
Dekura Yasuhiro, Nishioka Kentaro, Hashimoto Takayuki, Miyamoto Naoki, Suzuki Ryusuke, Matsumoto Ryuji, Osawa Takahiro, Abe Takashige, Maruyama Satoru, Shinohara Nobuo, Shirato Hiroki, Shimizu Shinichi
INTERNATIONAL JOURNAL OF UROLOGY, 25, 445, 445, Oct. 2018, [Peer-reviewed]
English - An analytical dose-averaged LET calculation algorithm considering the off-axis LET enhancement by secondary protons for spot-scanning proton therapy.
Hirayama S, Matsuura T, Ueda H, Fujii Y, Fujii T, Takao S, Miyamoto N, Shimizu S, Fujimoto R, Umegaki K, Shirato H
Medical physics, 45, 7, 3404, 3416, Jul. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: To evaluate the biological effects of proton beams as part of daily clinical routine, fast and accurate calculation of dose-averaged linear energy transfer (LETd ) is required. In this study, we have developed the analytical LETd calculation method based on the pencil-beam algorithm (PBA) considering the off-axis enhancement by secondary protons. This algorithm (PBA-dLET) was then validated using Monte Carlo simulation (MCS) results. METHODS: In PBA-dLET, LET values were assigned separately for each individual dose kernel based on the PBA. For the dose kernel, we employed a triple Gaussian model which consists of the primary component (protons that undergo the multiple Coulomb scattering) and the halo component (protons that undergo inelastic, nonelastic and elastic nuclear reaction); the primary and halo components were represented by a single Gaussian and the sum of two Gaussian distributions, respectively. Although the previous analytical approaches assumed a constant LETd value for the lateral distribution of a pencil beam, the actual LETd increases away from the beam axis, because there are more scattered and therefore lower energy protons with higher stopping powers. To reflect this LETd behavior, we have assumed that the LETs of primary and halo components can take different values (LETp and LEThalo ), which vary only along the depth direction. The values of dual-LET kernels were determined such that the PBA-dLET reproduced the MCS-generated LETd distribution in both small and large fields. These values were generated at intervals of 1 mm in depth for 96 energies from 70.2 to 220 MeV and collected in the look-up table. Finally, we compared the LETd distributions and mean LETd (LETd,mean ) values of targets and organs at risk between PBA-dLET and MCS. Both homogeneous phantom and patient geometries (prostate, liver, and lung cases) were used to validate the present method. RESULTS: In the homogeneous phantom, the LETd profiles obtained by the dual-LET kernels agree well with the MCS results except for the low-dose region in the lateral penumbra, where the actual dose was below 10% of the maximum dose. In the patient geometry, the LETd profiles calculated with the developed method reproduces MCS with the similar accuracy as in the homogeneous phantom. The maximum differences in LETd,mean for each structure between the PBA-dLET and the MCS were 0.06 keV/μm in homogeneous phantoms and 0.08 keV/μm in patient geometries under all tested conditions, respectively. CONCLUSIONS: We confirmed that the dual-LET-kernel model well reproduced the MCS, not only in the homogeneous phantom but also in complex patient geometries. The accuracy of the LETd was largely improved from the single-LET-kernel model, especially at the lateral penumbra. The model is expected to be useful, especially for proper recognition of the risk of side effects when the target is next to critical organs. - 同時期に異所性に発生した悪性腫瘍に対して、二部位同時にIMRTを施行した症例
湊川 英樹, 安田 耕一, 白土 博樹, 土屋 和彦, 原田 八重, 水町 貴諭, 坂下 智博, 本間 明宏, 福田 諭, 石嶋 漢, 宮本 直樹, 高尾 聖心, 鈴木 隆介, 松浦 妙子, 牧永 綾乃, 田村 昌也
Japanese Journal of Radiology, 36, Suppl., 6, 6, (公社)日本医学放射線学会, Feb. 2018
Japanese - Weighted reconstruction of three-dimensional refractive index in interferometric tomography
Satoshi Tomioka, Shusuke Nishiyama, Naoki Miyamoto, Daichi Kando, Samia Heshmat
APPLIED OPTICS, 56, 24, 6755, 6764, Aug. 2017, [Peer-reviewed]
English, Scientific journal - A simulation study on the dosimetric benefit of real-time motion compensation in spot-scanning proton therapy for prostate
Yusuke Fujii, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Takaaki Fujii, Naoki Miyamoto, Kikuo Umegaki, Kentaro Nishioka, Shinichi Shimizu, Hiroki Shirato
JOURNAL OF RADIATION RESEARCH, 58, 4, 591, 597, Jul. 2017, [Peer-reviewed]
English, Scientific journal - Analysis of inter- and intra fractional partial bladder wall movement using implanted fiducial markers
Kentaro Nishioka, Shinichi Shimizu, Nobuo Shinohara, Yoichi M. Ito, Takashige Abe, Satoru Maruyama, Norio Katoh, Rumiko Kinoshita, Takayuki Hashimoto, Naoki Miyamoto, Rikiya Onimaru, Hiroki Shirato
RADIATION ONCOLOGY, 12, 1, 44, Mar. 2017, [Peer-reviewed]
English, Scientific journal - Impact of Real-Time Image Gating on Spot Scanning Proton Therapy for Lung Tumors: A Simulation Study
Takahiro Kanehira, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Yusuke Fujii, Takaaki Fujii, Yoichi M. Ito, Naoki Miyamoto, Tetsuya Inoue, Norio Katoh, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 97, 1, 173, 181, Jan. 2017, [Peer-reviewed]
English, Scientific journal - 自由行動マウスの複数組織における時計遺伝子発現のin vivo追跡定量化 (Best articles of the year)
浜田俊幸, ケネスリーサザーランド, 石川正純, 宮本直樹, 本間さと, 白土博樹, 本間研一
The Hokkaido Journal of Medical Science, 91, 2, Nov. 2016, [Peer-reviewed] - Optimization and evaluation of multiple gating beam delivery in a synchrotron-based proton beam scanning system using a real-time imaging technique
Takahiro Yamada, Naoki Miyamoto, Taeko Matsuura, Seishin Takao, Yusuke Fujii, Yuka Matsuzaki, Hidenori Koyano, Masumi Umezawa, Hideaki Nihongi, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 32, 7, 932, 937, Jul. 2016, [Peer-reviewed], [Corresponding author]
English, Scientific journal - In vivo imaging of clock gene expression in multiple tissues of freely moving mice
Toshiyuki Hamada, Kenneth Sutherland, Masayori Ishikawa, Naoki Miyamoto, Sato Honma, Hiroki Shirato, Ken-ichi Honma
NATURE COMMUNICATIONS, 7, Jun. 2016, [Peer-reviewed]
English, Scientific journal - Evaluation of the motion of lung tumors during stereotactic body radiation therapy (SBRT) with four-dimensional computed tomography (4DCT) using real-time tumor-tracking radiotherapy system (RTRT)
Keiichi Harada, Norio Katoh, Ryusuke Suzuki, Yoichi M. Ito, Shinichi Shimizu, Rikiya Onimaru, Tetsuya Inoue, Naoki Miyamoto, Hiroki Shirato
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 32, 2, 305, 311, Feb. 2016, [Peer-reviewed]
English, Scientific journal - Development and evaluation of a short-range applicator for treating superficial moving tumors with respiratory-gated spot-scanning proton therapy using real-time image guidance
Taeko Matsuura, Yusuke Fujii, Seishin Takao, Takahiro Yamada, Yuka Matsuzaki, Naoki Miyamoto, Taisuke Takayanagi, Shinichiro Fujitaka, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki
PHYSICS IN MEDICINE AND BIOLOGY, 61, 4, 1515, 1531, Feb. 2016, [Peer-reviewed]
English, Scientific journal - Intrafractional Baseline Shift or Drift of Lung Tumor Motion During Gated Radiation Therapy With a Real-Time Tumor-Tracking System
Seishin Takao, Naoki Miyamoto, Taeko Matsuura, Rikiya Onimaru, Norio Katoh, Tetsuya Inoue, Kenneth Lee Sutherland, Ryusuke Suzuki, Hiroki Shirato, Shinichi Shimizu
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 94, 1, 172, 180, Jan. 2016, [Peer-reviewed]
English, Scientific journal - Dynamic image prediction using principle component and multi-channel singular spectral analysis: a feasibility study
Ritu Bhusal Chhatkuli, Kazuyuki Demachi, Naoki Miyamoto, Mitsuru Uesaka, Akihiro Haga
Open Journal of Medical Imaging, 5, 3, 133, 142, 09 Sep. 2015, [Peer-reviewed]
English, Scientific journal - Application of radiosurgical techniques to produce a primate model of brain lesions
Jun Kunimatsu, Naoki Miyamoto, Masayori Ishikawa, Hiroki Shirato, Masaki Tanaka
Frontiers in Systems Neuroscience, 9, 67, 1, 10, Frontiers Research Foundation, 24 Apr. 2015, [Peer-reviewed]
English, Scientific journal - Development of a wavelength-separated type scintillator with optical fiber (SOF) dosimeter to compensate for the Cerenkov radiation effect
Masayori Ishikawa, Naomi Nagase, Taeko Matsuura, Junichi Hiratsuka, Ryusuke Suzuki, Naoki Miyamoto, Kenneth Lee Sutherland, Katsuhisa Fujita, Hiroki Shirato
JOURNAL OF RADIATION RESEARCH, 56, 2, 372, 381, Mar. 2015, [Peer-reviewed]
English, Scientific journal - International standardization of four dimensional radiotherapy system — Enhancement of effects of irradiation and assurance of safety &mdash
Hirata, Yuichi, Miyamoto, Naoki, Shimizu, Morihito, Yoshida, Mitsuhiro, Hiramoto, Kazuo, Ichikawa, Yoshiaki, Kaneko, Shuji, Sasagawa, Tsuyoshi, Hiraoka, Masahiro, Shirato, Hiroki
Synthesiology English edition, 7, 4, 229, 238, National Institute of Advanced Industrial Science and Technology, 2015, [Peer-reviewed]
English, Scientific journal, In radiation therapy for cancer, there are possibilities of position changes of the affected area during irradiation due to respiration of a patient. In order to enhance effects of irradiation for the affected area and minimize damages to the surrounding normal tissues, four dimensional radiotherapy (4DRT), which can take into account time variation of the three-dimensional position of the affected area, has been recently developed, and has been achieving significant therapeutic effects. We have proposed the International Electrotechnical Commission (IEC) standards including technical requirements of the safety aspects of the systems which realize this 4DRT, taking into account the time aspect. The reason for the proposal is that international standardization will be very effective to ensure safety of 4DRT, and international standards of IEC will have compelling force if regulatory agencies refer to them. The purpose of this paper is to summarize the analysis of the strategy in a precedent endeavor toward international standardization of the 4DRT systems, for which demands are increasing. The main point of the strategy is forming an international consensus by bringing together the opinions of specialists from various fields from a clinical point of view, focusing on the international standardization of the technical requirements of the safety aspects of the 4DRT. Based on such a strategy, we will promote developing new standards by evaluating the overall safety of the 4DRT systems for further expanding use, in addition to updating existing standards of particular equipment which constitute the 4DRT systems. - A motion-compensated image filter for low-dose fluoroscopy in a real-time tumor-tracking radiotherapy system
Naoki Miyamoto, Masayori Ishikawa, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
JOURNAL OF RADIATION RESEARCH, 56, 1, 186, 196, Jan. 2015, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal - Preliminary analysis for integration of spot-scanning proton beam therapy and real-time imaging and gating
S. Shimizu, T. Matsuura, M. Umezawa, K. Hiramoto, N. Miyamoto, K. Umegaki, H. Shirato
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 30, 5, 555, 558, Jul. 2014, [Peer-reviewed]
English, Scientific journal - A Proton Beam Therapy System Dedicated to Spot-Scanning Increases Accuracy with Moving Tumors by Real-Time Imaging and Gating and Reduces Equipment Size
Shinichi Shimizu, Naoki Miyamoto, Taeko Matsuura, Yusuke Fujii, Masumi Umezawa, Kikuo Umegaki, Kazuo Hiramoto, Hiroki Shirato
PLOS ONE, 9, 4, Apr. 2014, [Peer-reviewed]
English, Scientific journal - 高精度放射線治療における呼吸性移動対策のコツとピットフォール RTRTによる呼吸性移動対策:有用性と今後の展望
宮本直樹, 石川正純, 井上哲也, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹
Rad Fan, 12, 3, 70-73,20, 73, (株)メディカルアイ, 25 Feb. 2014
Japanese - International standardization of four dimensional radiotherapy system:— Enhancement of effects of irradiation and assurance of safety —
HIRATA Yuichi, SHIRATO Hiroki, MIYAMOTO Naoki, SHIMIZU Morihito, YOSHIDA Mitsuhiro, HIRAMOTO Kazuo, ICHIKAWA Yoshiaki, KANEKO Shuji, SASAGAWA Tsuyoshi, HIRAOKA Masahiro
Synthesiology, 7, 4, 238, 246, National Institute of Advanced Industrial Science and Technology, 2014, [Peer-reviewed]
Japanese, In radiation therapy for cancer, there are possibilities of changing of positions of the affected area during irradiation due to respiration of a patient. In order to enhance effects of irradiation for the affected area and minimize damages to the surrounding normal tissues, four dimensional radiotherapy (4DRT), which can take into account time variation of the three-dimensional position of the affected area, has been recently developed, and has been achieving significant therapeutic effect. We have proposed the International Electrotechnical Commission (IEC) standards including technical requirements of the safety aspects of the systems which realize this 4DRT, taking into account the time variation. The reason for the proposal is that international standardization will be very effective to ensure safety of 4DRT, and international standards of IEC will have compelling force if regulatory agencies refer to them. The purpose of this paper is to summarize the analysis of the strategy in a precedent endeavor toward international standardization of the 4DRT systems, for which demands are increasing. The main point of the strategy is forming an international consensus by bringing together the opinions of specialists from various fields from a clinical point of view, focusing on the international standardization of the technical requirements of the safety aspects of the 4DRT. Based on such a strategy, we will promote developing new standards by evaluating the overall safety of the 4DRT systems for further expanding use, in addition to updating existing standards of particular equipment which constitute the 4DRT systems. - Prospective phase II study of image-guided local boost using a real-time tumor-tracking radiotherapy (RTRT) system for locally advanced bladder cancer
Nishioka K, Shimizu S, Shinohara N, Ito Y. M, Abe T, Maruyama S, Kinoshita R, Harada K, Nishikawa N, Miyamoto N, Onimaru R, Shirato H
Jpn J Clin Oncol, 44, 1, 28, 35, 2014, [Peer-reviewed] - Prospective Phase II Study of Image-guided Local Boost Using a Real-time Tumor-tracking Radiotherapy (RTRT) System for Locally Advanced Bladder Cancer
Kentaro Nishioka, Shinichi Shimizu, Nobuo Shinohara, Yoichi M. Ito, Takashige Abe, Satoru Maruyama, Rumiko Kinoshita, Keiichi Harada, Noboru Nishikawa, Naoki Miyamoto, Rikiya Onimaru, Hiroki Shirato
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 44, 1, 28, 35, Jan. 2014, [Peer-reviewed]
English, Scientific journal - 医療情報誘導治療の最新 リアルタイム4次元放射線治療の―スーパー特区の成果―
白土博樹, 鬼丸力也, 清水伸一, 石川正純, 宮本直樹, SUTHERLAND Ken, 鈴木隆介, 寅松千枝
映像情報Medical, 45, 7, 619, 623, 01 Jul. 2013
Japanese - Integration of a real-time tumor monitoring system into gated proton spot-scanning beam therapy: An initial phantom study using patient tumor trajectory data
Taeko Matsuura, Naoki Miyamoto, Shinichi Shimizu, Yusuke Fujii, Masumi Umezawa, Seishin Takao, Hideaki Nihongi, Chie Toramatsu, Kenneth Sutherland, Ryusuke Suzuki, Masayori Ishikawa, Rumiko Kinoshita, Kenichiro Maeda, Kikuo Umegaki, Hiroki Shirato
MEDICAL PHYSICS, 40, 7, 071729-11, 071729-1, Jul. 2013, [Peer-reviewed]
English, Scientific journal - What is the appropriate size criterion for proton radiotherapy for hepatocellular carcinoma? A dosimetric comparison of spot-scanning proton therapy versus intensity-modulated radiation therapy
Chie Toramatsu, Norio Katoh, Shinichi Shimizu, Hideaki Nihongi, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Ryusuke Suzuki, Kenneth Sutherland, Rumiko Kinoshita, Rikiya Onimaru, Masayori Ishikawa, Kikuo Umegaki, Hiroki Shirato
RADIATION ONCOLOGY, 8, 48, Mar. 2013, [Peer-reviewed]
English, Scientific journal - Can 4DCT Imaging Predict Lung Motion During Stereotactic Body Radiation Therapy?
Harada K, Katoh N, Suzuki R, Inoue T, Omimaru R, Shimizu S, Miyamoto N, Ishikawa M, Shirato H
International Journal of Radiation Oncology Biology Physics, 87, 2, S67, 2013, [Peer-reviewed] - Baseline Shift of Intrafractional Lung Tumor Motion in Real-Time Tumor-Tracking Radiation Therapy
Takao S, Miyamoto N, Matsuura T, Shimizu S, Onimaru R, Katoh N, Inoue T, Shirato H
International Journal of Radiation Oncology Biology Physics, 87, 2, S67, 2013, [Peer-reviewed] - 一方向X線透視による低被曝・省スペース型動体追跡装置の開発
宮本直樹, 石川正純, SUTHERLAND Kenneth, 鈴木隆介, 松浦妙子, 高尾聖心, 寅松千枝, 二本木英明, 清水伸一, 梅垣菊男, 白土博樹
医学物理 Supplement, 32, 3, 281, 282, 13 Sep. 2012
Japanese - 体内複数マーカを用いた高精度ゲーティング照射法の基礎検討
大友可奈子, 宮本直樹, SUTHERLAND Kenneth, 鈴木隆介, 松浦妙子, 鬼丸力也, 清水伸一, 梅垣菊男, 白土博樹, 石川正純
医学物理 Supplement, 32, 3, 155, 156, 13 Sep. 2012
Japanese - 陽子線スキャニング照射における体内マーカーによる線量遮蔽のTCPを用いた評価
前田憲一郎, 松浦妙子, 高尾聖心, SUTHERLAND Kenneth, 寅松千枝, 二本木英明, 宮本直樹, 石川正純, 清水伸一, 梅垣菊男, 白土博樹
医学物理 Supplement, 32, 3, 101, 102, 13 Sep. 2012
Japanese - 陽子線治療における最適な治療ワークフローの検討
高尾聖心, 松浦妙子, 寅松千枝, 二本木英明, 宮本直樹, 清水伸一, 木下留美子, 松田浩二, 木谷貴雄, 梅垣菊男, 白土博樹
医学物理 Supplement, 32, 3, 169, 170, 13 Sep. 2012
Japanese - Biological effect of dose distortion by fiducial markers in spot-scanning proton therapy with a limited number of fields: A simulation study
Taeko Matsuura, Kenichiro Maeda, Kenneth Sutherland, Taisuke Takayanagi, Shinichi Shimizu, Seishin Takao, Naoki Miyamoto, Hideaki Nihongi, Chie Toramatsu, Yoshihiko Nagamine, Rintaro Fujimoto, Ryusuke Suzuki, Masayori Ishikawa, Kikuo Umegaki, Hiroki Shirato
MEDICAL PHYSICS, 39, 9, 5584, 5591, Sep. 2012, [Peer-reviewed]
English, Scientific journal - 治療計画シミュレーションによる陽子線スキャニング専用機の線量分布の検証
二本木英明, 寅松千枝, 松浦妙子, 高尾聖心, 宮本直樹, 梅垣菊男, 清水伸一, 木下留美子, 白土博樹
医学物理 Supplement, 32, 1, 190, 01 Apr. 2012
Japanese - Improvement of tracking accuracy and stability by recursive image processing in real-time tumor-tracking radiotherapy system
Naoki Miyamoto, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Rumiko Kinoshita, Shinichi Shimizu, Rikiya Onimaru, Kikuo Umegaki, Hiroki Shirato, Masayori Ishikawa
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8316, 2012, [Peer-reviewed]
International conference proceedings - The Role of Spot Scanning Proton Therapy in the Treatment of Large Abdominal Tumors: A Comparative Planning Study of Hepatocellular Carcinoma
Toramatsu C, Katoh N, Shimizu S, Nihongi H, Matsuura T, Takao S, Miyamoto N, Kinoshita R, Umegaki K, Shirato H
International Journal of Radiation Oncology Biology Physics, 84, 3, S327, S328, 2012, [Peer-reviewed] - Improvement of tracking accuracy and stability by recursive image processing in real-time tumor-tracking radiotherapy system
Naoki Miyamoto, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Rumiko Kinoshita, Shinichi Shimizu, Rikiya Onimaru, Kikuo Umegaki, Hiroki Shirato, Masayori Ishikawa
MEDICAL IMAGING 2012: IMAGE-GUIDED PROCEDURES, ROBOTIC INTERVENTIONS, AND MODELING, 8316, 2012
English, International conference proceedings - Optimization of fluoroscopy parameters using pattern matching prediction in the real-time tumor-tracking radiotherapy system
Naoki Miyamoto, Masayori Ishikawa, Gerard Bengua, Kenneth Sutherland, Ryusuke Suzuki, Suguru Kimura, Shinichi Shimizu, Rikiya Onimaru, Hiroki Shirato
PHYSICS IN MEDICINE AND BIOLOGY, 56, 15, 4803, 4813, Aug. 2011, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal - A feasibility study of a molecular-based patient setup verification method using a parallel-plane PET system
Satoshi Yamaguchi, Masayori Ishikawa, Gerard Bengua, Kenneth Sutherland, Teiji Nishio, Satoshi Tanabe, Naoki Miyamoto, Ryusuke Suzuki, Hiroki Shirato
PHYSICS IN MEDICINE AND BIOLOGY, 56, 4, 965, 977, Feb. 2011, [Peer-reviewed]
English, Scientific journal - Phase unwrapping for noisy phase maps using rotational compensator with virtual singular points
Satoshi Tomioka, Samia Heshmat, Naoki Miyamoto, Shusuke Nishiyama
APPLIED OPTICS, 49, 25, 4735, 4745, Sep. 2010, [Peer-reviewed]
English, Scientific journal - 生物学的効果を考慮した治療計画—Dose Volume Histogram解析による考察—
関原和正, 石川正純, SUTHERLAND Kenneth, BENGUA Gerard, 宮本直樹, 鈴木隆介, 清水伸一, 白土博樹
Jpn J Radiol, 28, Supplement 1, 15, 15, (公社)日本医学放射線学会, 25 Jul. 2010
Japanese - The impact of 18F-fluoromisonidazole PET for H&N cancer and the applying for IMRT
YASUDA KOICHI, HASEGAWA MASAICHI, ONIMARU RIKIYA, KINOSHITA RUMIKO, KATO NORIO, TAGUCHI HIROSHI, SHIMIZU SHIN'ICHI, INOUE TETSUYA, ONODERA SHUNSUKE, MIZOGUCHI FUMIKI, AOYAMA HIDEFUMI, SHIRATO HIROKI, SHIGA SATORU, OKAMOTO SHOZO, TAMAKI NAGARA, ISHIKAWA MASAZUMI, SUTHERLAND KENNETH, BENGUA GERARD, MIYAMOTO NAOKI, SUZUKI TAKASUKE
Jpn J Radiol, 28, Supplement 1, 14, 14, (公社)日本医学放射線学会, 25 Jul. 2010
Japanese - Phase unwrapping for noisy phase maps using rotational compensator with virtual singular points
Satoshi Tomioka, Samia Heshmat, Naoki Miyamoto, Shusuke Nishiyama
Applied Optics, 49, 25, 4735, 2010, [Peer-reviewed]
English, Scientific journal - 動体追跡装置におけるコントラスト‐ノイズ比の測定方法の検討
木村傑, 宮本直樹, 石川正純, SUTHERLAND Kenneth, BENGUA Gerard, 鈴木隆介, 清水伸一, 青山英史, 鬼丸力也, 白土博樹
医学物理 Supplement, 29, 3, 148-149, Sep. 2009
Japanese - 動体追跡放射線治療におけるX線透視条件の最適化
宮本直樹, SUTHERLAND Kenneth, 石川正純, 鈴木隆介, BENGUA Gerard, 木村傑, 清水伸一, 青山英史, 鬼丸力也, 白土博樹
医学物理 Supplement, 29, 3, 150-151, Sep. 2009
Japanese - 動体追跡装置を用いた肺定位照射時の投与線量解析—動体追跡データに基づくDVH解析—
石川正純, サザランド ケネス, ベングア ジェラード, 鈴木隆介, 宮本直樹, 加藤徳雄, 清水伸一, 鬼丸力也, 青山英史, 白土博樹
日本放射線腫よう学会誌, 21, Supplement 1, 158, 19 Aug. 2009
Japanese - Epithermal neutron tomography using compact electron linear accelerator
T. Kamiyama, N. Miyamoto, S. Tomioka, T. Kozaki
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 605, 1-2, 91, 94, Jun. 2009, [Peer-reviewed]
English, Scientific journal - 対向型PET装置を用いた分子イメージング動体追跡装置の開発〜18F点線源を用いた追跡精度の検証〜
棚邊哲史, 石川正純, 山口哲, 武島嗣英, 鈴木隆介, 宮本直樹, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹
医学物理 Supplement, 29, 2, 101-102, Apr. 2009
Japanese - 体内臓器同期照射を目的とした次世代動体追跡装置の開発〜透視画像の歪みと位置計算誤差〜
宮本直樹, SUTHERLAND Kenneth, 石川正純, 鈴木隆介, BENGUA Gerard, 木村傑, 清水伸一, 青山英史, 鬼丸力也, 白土博樹
医学物理 Supplement, 29, 2, 192-193, Apr. 2009
Japanese - 体内臓器同期照射を目的とした次世代動体追跡装置の開発〜デジタル画像機器としての定量的評価〜
木村傑, 石川正純, SUTHERLAND Kenneth, 宮本直樹, BENGUA Gerard, 鈴木隆介, 清水伸一, 青山英史, 鬼丸力也, 白土博樹
医学物理 Supplement, 29, 2, 196-197, Apr. 2009
Japanese - 体内臓器同期照射を目的とした次世代動体追跡装置の開発〜複数マーカ追跡への挑戦〜
石川正純, SUTHERLAND Kenneth, 宮本直樹, BENGUA Gerard, 清水伸一, 青山英史, 鬼丸力也, 木村傑, 白土博樹
医学物理 Supplement, 29, 2, 194-195, Apr. 2009
Japanese - Energy sliced neutron tomography using neutron resonance absorption spectrometer
Takashi Kamiyama, Hirotaka Sato, Naoki Miyamoto, Hirokatsu Iwasa, Yoshiaki Kiyanagi, Susumu Ikeda
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 600, 1, 107, 110, 21 Feb. 2009, [Peer-reviewed]
English, Scientific journal - Quantitative epithermal neutron tomography with compact pulsed neutron source
Takashi Kamiyama, Naoki Miyamoto, Satoshi Tomioka, Tamotsu Kozaki
IEEE Nuclear Science Symposium Conference Record, 1266, 1270, 2009, [Peer-reviewed]
English, International conference proceedings - Quantitative epithermal neutron tomography with compact pulsed neutron source
T. Kamiyama, N. Miyamoto, S. Tomioka, T. Kozaki
2009 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE RECORD (NSS/MIC), 1266, 1270, 2009 - Can the Real-time Tumor-tracking Radiotherapy Give the Planned Dose to the Tumor? DVH Analysis Based on Measured Real-time Tracking Data
Ishikawa M, Sutherland KL, Bengua G, Suzuki R, Miyamoto N, Katoh N, Shimizu S, Onimaru R, Aoyama H, Shirato
International Journal of Radiation Oncology Biology Physics, 75, 3, S590, S591, 2009, [Peer-reviewed] - Numerical reconstruction of an infrared wavefront utilizing an optical phase modulation device
Naoki Miyamoto, Shusuke Nisiyama, Satoshi Tomioka, Takeaki Enoto
OPTICS COMMUNICATIONS, 272, 1, 67, 72, Apr. 2007, [Peer-reviewed]
English, Scientific journal - Epithermal neutron tomography with time-of-flight technique
T. Kamiyama, H. Sato, N. Miyamoto, H. Iwasa, Y. Kiyanagi, S. Ikeda
IEEE Nuclear Science Symposium Conference Record, 2, 1720, 1724, 2007, [Peer-reviewed]
English, International conference proceedings - Study of Neutron Tomography using Neutron Resonance Absorption
T. Kamiyama, H. Sato, N. Miyamoto, H. Iwasa, Y. Kiyanagi, S. Ikeda
Proceedings of 18th Meeting of the International Collaboration on Advanced Neutron Sources (ICANS-XVIII), 2007
English, International conference proceedings - Epithermal neutron tomography with time-of-flight technique
T. Kamiyama, H. Sato, N. Miyamoto, H. Iwasa, Y. Kiyanagi, S. Ikeda
2007 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE RECORD (NSS/MIC), 1720, 1725, Jan. 2007 - Application of the nitroanisole as an infrared detector used in middle infrared interferometer
N Miyamoto, S Nisiyama, S Tomioka, T Enoto
OPTICS COMMUNICATIONS, 260, 1, 25, 29, Apr. 2006, [Peer-reviewed]
English, Scientific journal - Infrared phase-shifting interferometry using the nitroanisole as a two-dimensional detector
Naoki Miyamoto, Shusuke Nisiyama, Satoshi Tomioka, Takeaki Enoto
Proceedings of SPIE - The International Society for Optical Engineering, 6049, 202, 211, 2005
English, International conference proceedings
Other Activities and Achievements
- 強度変調放射線治療(IMRT)を行った下咽頭癌における再発症例の検討
大塚愛美, 安田耕一, 湊川英樹, 出倉康裕, 青山英史, 清水伸一, 鈴木隆介, 宮本直樹, 清水伸一, 鈴木崇祥, 対馬那由多, 加納里志, 田口純, 清水康, 本間明宏, 清水伸一, Japanese Journal of Radiology, 40, Supplement, 2022 - 18F-DiFA PET/CTイメージングを用いたエリブリンによる腫瘍内低酸素解除効果の解析と放射線増感作用の検討(Eribulin improves tumor oxygenation demonstrated by 18F-DiFA hypoxia imaging, leading to radio-sensitization in human breast cancer xenograft model)
房 知輝, 安井 博宣, 志賀 哲, 柴田 悠貴, 藤本 政毅, 鈴木 基史, 東川 桂, 宮本 直樹, 稲波 修, 久下 裕司, 日本放射線影響学会大会講演要旨集, 63回, 119, 119, Oct. 2020
(一社)日本放射線影響学会, English - 画像誘導陽子線治療の将来展望
田口大志, 橋本孝之, 橋本孝之, 加藤徳雄, 木下留美子, 安田耕一, 西岡健太郎, 西岡健太郎, 森崇, 打浪雄介, 宮本直樹, 高尾聖心, 清水伸一, 清水伸一, 青山英史, 日本癌治療学会学術集会(Web), 58th, 2020 - SLD repair impact on prolonged proton irradiation with various cell specific parameters
KASAMATSU Koki, MATSUURA Taeko, MATSUURA Taeko, TAKAO Seishin, TAKAO Seishin, TANAKA Sodai, TANAKA Sodai, MIYAMOTO Naoki, MIYAMOTO Naoki, NAM Jin-Min, SHIRATO Hiroki, SHIRATO Hiroki, UMEGAKI Kikuo, UMEGAKI Kikuo, 日本医学物理学会学術大会報文集, 119th, 2020 - Training convolutional neural network using experimental data in phase extraction for 3D refractive-index measurement
貫洞大地, 柳瀬佳亮, 富岡智, 宮本直樹, 上田亮介, HESHMAT Samia, Optics & Photonics Japan講演予稿集(CD-ROM), 2019, 2019 - 前立腺癌治療の新たな展開:ハイリスク前立腺癌に対する拡大手術、粒子線治療、ネオアジュバント治療 ハイリスク前立腺がんに対する強度変調放射線治療・陽子線治療 現状と可能性
清水 伸一, 橋本 孝之, 西岡 健太郎, 安部 崇重, 大澤 崇宏, 松本 隆児, 松浦 妙子, 宮本 直樹, 高尾 聖心, 鈴木 隆介, 梅垣 菊男, 篠原 信雄, 白土 博樹, 日本癌治療学会学術集会抄録集, 56回, SY5, 2, Oct. 2018
(一社)日本癌治療学会, English - An Organ Motion and Acute Toxicity Study of Image-Guided Spot-Scanning Proton Beam Therapy With An Internal Fiducial Marker for Pancreatic Cancers.
Y. Uchinami, N. Katoh, D. Abo, K. Harada, Y. Nishikawa, T. Inoue, T. Hashimoto, R. Onimaru, N. Miyamoto, Y. Sakuhara, S. Shimizu, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 99, 2, E194, E194, Oct. 2017
English, Summary international conference - 頭蓋底腫瘍術後に強度変調放射線治療を行った2例
森 崇, 宮本 直樹, 鈴木 隆介, 鬼丸 力也, 白土 博樹, Japanese Journal of Radiology, 35, Suppl., 4, 4, Feb. 2017
(公社)日本医学放射線学会, Japanese - Analysis of Durations and Dose Rates for Treatment of Moving Liver Tumors Using Real-Time Image Gated Spot Scanning Proton Beam Therapy
S. Shimizu, N. Katoh, T. Hashimoto, K. Nishioka, T. Yoshimura, S. Takao, T. Matsuura, N. Miyamoto, K. Umegaki, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 96, 2, S211, S212, Oct. 2016
English, Summary international conference - 食道IMRTにおけるintra-fractional organ motionの影響
田村 弘詞, 宮本 直樹, 鈴木 隆介, 堀田 賢治, 藤田 勝久, 井上 哲也, 日本放射線技術学会雑誌, 72, 9, 873, 874, Sep. 2016
(公社)日本放射線技術学会, Japanese - Simulation Study of Real-Time-Image Gating On Spot Scanning Proton Therapy for Lung Tumors
T. Kanehira, T. Matsuura, S. Takao, Y. Matsuzaki, Y. Fujii, T. Fujii, N. Miyamoto, T. Inoue, N. Katoh, S. Shimizu, K. Umegaki, H. Shirato, MEDICAL PHYSICS, 43, 6, Jun. 2016
English, Summary international conference - Software Development for 4D-CBCT Research of Real-Time-Image Gated Spot Scanning Proton Therapy
T. Fujii, T. Matsuura, S. Takao, N. Miyamoto, Y. Matsuzaki, Y. Fujii, K. Umegaki, S. Shimizu, H. Shirato, MEDICAL PHYSICS, 43, 6, 3389, 3389, Jun. 2016
English, Summary international conference - Treatment Time and Dose Rate Analysis for Respiratory Moving Liver Tumor Using Real-time-image Gated Spot Scanning Proton Beam Therapy System
SHIMIZU Shinichi, KATOH Norio, TAKAO Seishin, MATSUURA Taeko, MIYAMOTO Naoki, HASHIMOTO Takayuki, NISHIOKA Kentaro, YOSHIMURA Takaaki, UMEGAKI Kikuo, SHIRATO Hiroki, 日本医学放射線学会総会抄録集, 75th, S225, S225, 29 Feb. 2016
(公社)日本医学放射線学会, English - 【呼吸性移動対策の今後-光子線治療から粒子線治療まで-】 次世代型動体追跡放射線治療システムの臨床応用と今後の展望
宮本 直樹, 石川 正純, 井上 哲也, 加藤 徳雄, 清水 伸一, 鬼丸 力也, 白土 博樹, 臨床放射線, 61, 2, 293, 302, Feb. 2016
金原出版(株), Japanese - 椎体IMRTとその精度に関する研究
安田 耕一, 清水 伸一, 橋本 孝之, Sutherland Ken, 白土 博樹, 土屋 和彦, 加藤 徳雄, 鬼丸 力也, 木下 留美子, 井上 哲也, 西岡 健太郎, 西川 由記子, 森 崇, 原田 慶一, 原田 八重, 鈴木 隆介, 寅松 千枝, 松浦 妙子, 高尾 聖心, 宮本 直樹, 伊藤 陽一, Japanese Journal of Radiology, 34, Suppl., 5, 5, Feb. 2016
(公社)日本医学放射線学会, Japanese - 照射中と4DCT撮像時の肺内マーカー移動の比較
原田 慶一, 加藤 徳雄, 井上 哲也, 鬼丸 力也, 清水 伸一, 白土 博樹, 鈴木 隆介, 宮本 直樹, 石川 正純, Japanese Journal of Radiology, 34, Suppl., 10, 10, Feb. 2016
(公社)日本医学放射線学会, Japanese - Target Residual Motion During Beam Delivery in Gated Irradiation Using Real Time Tumor Tracking Radiation Therapy System: Analysis of Simultaneous Motion of Multiple Internal Fiducial Markers
N. Miyamoto, M. Ishikawa, R. Suzuki, A. Makinaga, T. Matsuura, S. Takao, Y. Matsuzaki, T. Inoue, N. Katoh, S. Shimizu, R. Onimaru, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93, 3, E554, E554, Nov. 2015
English, Summary international conference - Development of a Real-Time Image Gated Proton Beam Therapy (RGPT) System and Its Initial Clinical Application to Respiratory Moving Liver Tumors
S. Shimizu, N. Katoh, S. Takao, T. Matsuura, N. Miyamoto, T. Hashimoto, K. Nishioka, T. Yoshimura, Y. Matsuzaki, R. Kinoshita, Y. Nishikawa, R. Onimaru, K. Umegaki, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93, 3, S42, S42, Nov. 2015
English, Summary international conference - 新規動体追跡技術により可能になる3D imagingによる自由行動マウスの全身の遺伝子発現追跡定量法の開発
浜田 俊幸, 石川 正純, Sutherland Kenneth, 宮本 直樹, 白土 博樹, 本間 さと, 本間 研一, バイオイメージング, 24, 2, 114, 114, Sep. 2015
日本バイオイメージング学会, Japanese - Future of stereotactic irradiation - dose composition radiotherapy (DCRT)
Hiroki Shirato, Rikiya Onimaru, Shinichi Shimizu, Naoki Miyamoto, Ruijiang Li, Albert C. Koong, Masahiro Mizuta, Stereotactic Body Radiation Therapy: Principles and Practices, 239, 250, 06 Aug. 2015 - Development and Commissioning of Real-Time Imaging Function for Respiratory-Gated Spot-Scanning Proton Beam Therapy
N. Miyamoto, S. Takao, T. Matsuura, Y. Matsuzaki, T. Yamada, Y. Fujii, Y. Matsuo, T. Kidani, Y. Egashira, T. Umekawa, S. Shimizu, H. Shirato, K. Umegaki, MEDICAL PHYSICS, 42, 6, 3678, 3678, Jun. 2015
English, Summary international conference - Development of Evaluation System of Optimal Synchrotron Controlling Parameter for Spot Scanning Proton Therapy with Multiple Gate Irradiations in One Operation Cycle
T. Yamada, N. Miyamoto, T. Matsuura, S. Takao, Y. Matsuzaki, Y. Fujii, H. Koyano, H. Nihongi, M. Umezawa, K. Matsuda, K. Umegaki, H. Shirato, MEDICAL PHYSICS, 42, 6, 3394, 3394, Jun. 2015
English, Summary international conference - Startup Experience of the New Proton Beam Therapy System with Gated Spot Scanning and Real-Time Tumor-Tracking
K. Umegaki, T. Matsuuta, S. Takao, Y. Matsuzaki, T. Yamada, Y. Fujii, N. Miyamoto, S. Shimizu, H. Shirato, MEDICAL PHYSICS, 42, 6, 3728, 3728, Jun. 2015
English, Summary international conference - Development of An Applicator for Treating Shallow and Moving Tumors with Respiratory-Gated Spot-Scanning Proton Therapy Using Real-Time Image Guidance
T. Matsuura, Y. Fujii, S. Takao, T. Yamada, Y. Matsuzaki, N. Miyamoto, T. Takayanagi, S. Fujitaka, S. Shimizu, H. Shirato, K. Umegaki, MEDICAL PHYSICS, 42, 6, 3207, 3208, Jun. 2015
English, Summary international conference - Influence of the Intrafraction Patient Repositioning On Spot Scanning Proton Therapy for Prostate Cancer
Y. Fujii, T. Matsuura, S. Takao, Y. Matsuzaki, T. Yamada, N. Miyamoto, S. Shimizu, K. Umegaki, H. Shirato, MEDICAL PHYSICS, 42, 6, 3449, 3449, Jun. 2015
English, Summary international conference - 新規4D imagingによる自由行動マウスの全身の時計遺伝子発現制御機構の解析
浜田 俊幸, Sutherland Kenneth, 石川 正純, 宮本 直樹, 本間 さと, 白土 博樹, 本間 研一, 日本薬学会年会要旨集, 135年会, 2, 290, 290, Mar. 2015
(公社)日本薬学会, Japanese - 4DCTを用いた肺内マーカー移動の解析
加藤 徳雄, 原田 慶一, 鈴木 隆介, 井上 哲也, 鬼丸 力也, 清水 伸一, 宮本 直樹, 白土 博樹, Japanese Journal of Radiology, 33, Suppl., 5, 5, Feb. 2015
(公社)日本医学放射線学会, Japanese - 【放射線治療活用BOOK 2014】 (DIVISION-3)これからの放射線治療の展望 最新の動体追跡放射線治療装置
宮本 直樹, 石川 正純, 松浦 妙子, 井上 哲也, 加藤 徳雄, 清水 伸一, 鬼丸 力也, 梅垣 菊男, 白土 博樹, Rad Fan, 12, 15, 75, 77, Dec. 2014
(株)メディカルアイ, Japanese - Realization of the Cone Beam CT by FPDs That Mounted on the Spot-Scanning Dedicated Proton Beam Gantry
S. Shimizu, S. Takao, T. Matsuura, N. Miyamoto, R. Baba, T. Umekawa, K. Matsuda, T. Sasaki, Y. Nagamine, K. Umegaki, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 90, S920, S920, Sep. 2014
English, Summary international conference - 新動体追跡システムにおけるゲート照射時のビーム特性の評価
田村 弘詞, 宮本 直樹, 藤田 勝久, 堀田 賢治, 斉藤 英一, 日本放射線技術学会雑誌, 70, 9, 973, 973, Sep. 2014
(公社)日本放射線技術学会, Japanese - International standardization of four dimensional radiotherapy system - Enhancement of effects of irradiation and assurance of safety
Yuichi Hirata, Naoki Miyamoto, Morihito Shimizu, Mitsuhiro Yoshida, Kazuo Hiramoto, Yoshiaki Ichikawa, Shuji Kaneko, Tsuyoshi Sasagawa, Masahiro Hiraoka, Hiroki Shirato, Synthesiology, 7, 4, 238, 246, 01 Jan. 2014
National Institute of Advanced Industrial Science and Technology, English - 覚醒マウス嗅球および皮膚における時計遺伝子発現の4Dイメージング
浜田俊幸, 石川正純, SUTHERLAND K, 宮本直樹, 白土博樹, 本間さと, 本間研一, 日本生理学雑誌, 75, 4, 206, 207, 01 Jul. 2013
Japanese - SU‐E‐T‐448: Effectiveness of An In‐Gate Beam Tracking Method in Spot‐Scanning Proton Therapy
T. Matsuura, Y. Fujii, R. Fujimoto, M. Umezawa, N. Miyamoto, K. Sutherland, S. Takao, H. Nihongi, C. Toramatsu, S. Shimizu, K. U. Megaki, H. Shirato, Medical Physics, 40, 6, 308, 2013
English - SU‐E‐J‐57: A Feasibility Study On Molecular‐Imaging‐Based Real‐Time Tumor Tracking for Gated Radiotherapy
M. Ishikawa, S. Tanabe, S. Yamaguchi, N. Ukon, T. Yamanaka, K. Sutherland, N. Miyamoto, R. Suzuki, N. Katoh, K. Yasuda, H. Shirato, Medical Physics, 40, 162, 01 Jan. 2013 - Development of the compact proton beam therapy system dedicated to spot scanning with real-time tumor-tracking technology
Masumi Umezawa, Rintaro Fujimoto, Tooru Umekawa, Yuusuke Fujii, Taisuke Takayanagi, Futaro Ebina, Takamichi Aoki, Yoshihiko Nagamine, Koji Matsuda, Kazuo Hiramoto, Taeko Matsuura, Naoki Miyamoto, Hideaki Nihongi, Kikuo Umegaki, Hiroki Shirato, AIP Conference Proceedings, 1525, 360, 363, 2013
English - SU‐E‐J‐42: Motion Adaptive Image Filter for Low Dose X‐Ray Fluoroscopy in the Real‐Time Tumor‐Tracking Radiotherapy System
N. Miyamoto, M. Ishikawa, K. Sutherland, R. Suzuki, T. Matsuura, S. Takao, C. Toramatsu, H. Nihongi, S. Shimizu, R. Onimaru, K. Umegaki, H. Shirato, Medical Physics, 39, 6, 3661, 3662, Jun. 2012 - リアルタイム分子イメージングを用いた治療ビームゲーティングに関する基礎検討
右近直之, 棚邊哲史, 棚邊哲史, 山中琢, 山口哲, SUTHERLAND Kenneth, 鈴木隆介, 宮本直樹, 白土博樹, 石川正純, 医学物理 Supplement, 32, 3, 2012 - MO‐F‐213AB‐04: Biological Effect of Dose Shadowing by Fiducial Markers in Spot Scanning Proton Therapy with a Limited Number of Fields
T. Matsuura, K. Maeda, K. Sutherland, T. Takayanagi, S. Shimizu, S. Takao, H. Nihongi, C. Toramatsu, N. Miyamoto, Y. Nagamine, R. Fujimoto, K. Umegaki, H. Shirato, Medical Physics, 39, 6, 3872, 2012
English - SU‐E‐T‐506: Dosimetric Study for Shallow‐Seated Tumor Using Passive/active Scanning Proton Beam
C. Toramatsu, T. Matsuura, H. Nihongi, S. Takao, N. Miyamoto, S. Shimizu, R. Kinoshita, K. Umegaki, H. Shirato, Medical Physics, 39, 3821, 3822, 01 Jan. 2012 - 鼻腔・副鼻腔癌に対する超選択的動注を併用した根治的化学放射線療法
長谷川雅一, 安田耕一, 吉田大介, 加藤徳雄, 鬼丸力也, 浅野剛, 白土博樹, 本間明宏, 折舘伸彦, 福田諭, 石川正純, BENGUA Gerard, SUTHERLAND Kenneth, 宮本直樹, 鈴木隆介, Jpn J Radiol, 28, Supplement 1, 7, 7, 25 Jul. 2010
(公社)日本医学放射線学会, Japanese - 診断X線領域における極微小SOF線量計による被曝線量評価
石川正純, 江口菜弥帆, 作原大介, 阿保大介, 太田真緒, SUTHERLAND Kenneth, BENGUA Gerard, 鈴木隆介, 宮本直樹, 白土博樹, 日本医学放射線学会総会抄録集, 69th, S378, S378, 28 Feb. 2010
(公社)日本医学放射線学会, Japanese - Conceptual Design of PET-linac System for Molecular-guided Radiotherapy
M. Ishikawa, S. Yamaguchi, S. Tanabe, G. Bengua, K. Sutherland, R. Suzuki, N. Miyamoto, K. Nishijima, N. Katoh, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 78, 3, S674, S674, 2010
English, Summary international conference - Improvement of Tracking Accuracy and Stability with Utilizing a Color Image Intensifier in Real-time Tumor-tracking Radiotherapy System
N. Miyamoto, M. Ishikawa, G. Bengua, K. Sutherland, R. Suzuki, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 78, 3, S678, S678, 2010
English, Summary international conference - Feasibility Study on Molecular-imaging Based Tracking System for Lung Cancer Treatment
S. Tanabe, M. Ishikawa, S. Yamaguchi, G. Bengua, K. Sutherland, R. Suzuki, N. Miyamoto, N. Katoh, R. Onimaru, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 78, 3, S749, S749, 2010
English, Summary international conference - 小型加速器中性子源を用いた中性子共鳴吸収断層撮像
加美山隆, 宮本直樹, 富岡智, 小崎完, 日本原子力学会秋の大会予稿集(CD-ROM), 2008, 0, I13, 164, 21 Aug. 2008
本研究では、原子力用途を第一の目的とした核種分布の非破壊分析システムを構築するため、中性子共鳴吸収分光法(Neutron Resonance Absorption Spectroscopy; N-RAS)と計算機断層撮像法(Computer Tomography; CT)法の組み合わせによる分析法(N-RAS/CT)を提案し、実際に北海道大学の45MeV電子線ライナックに中性子共鳴吸収分光器および断層撮像用CTステージを建設した。これを用いて断層撮像用の中性子共鳴吸収スペクトル測定を行うことで、小型加速器中性子源を用いた測定システムにおいて1mm程度の分解能で核種分布の断層イメージング結果が得られた。, 一般社団法人 日本原子力学会, Japanese - 小型加速器を利用した中性子共鳴吸収CTによる核種分布の非破壊分析
宮本直樹, 小崎完, 富岡智, 加美山隆, 日本非破壊検査協会大会講演概要集, 2007, 335, 338, 18 Oct. 2007
Japanese - 中性子共鳴吸収分光法と計算機断層撮像法を利用した核種分布の非破壊分析
宮本直樹, 小崎完, 富岡智, 加美山隆, 日本原子力学会秋の大会予稿集(CD-ROM), 2007, 0, C51, 171, 07 Sep. 2007
中性子共鳴吸収分光法と計算機断層撮像法を組み合わせることにより、非破壊で核種分布を断層撮影することが可能な分析法の開発を目的としている。複数の核種の存在分布、およびその密度分布を再構成できることを示した。, 一般社団法人 日本原子力学会, Japanese
Lectures, oral presentations, etc.
- Evaluation of measurement accuracy of novel monoscopic X-ray imaging technique for three-dimensional target localization using multiple internal fiducial markers
Naoki Miyamoto, Ryusuke Suzuki, Seishin Takao, Taeko Matsuura, Shusuke Hirayama, Takaaki Fujii, Satoshi Tomioka, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
第114回医学物理学会, 15 Sep. 2017, English, Oral presentation
大阪, [Domestic Conference] - Target tumor localization algorithm using multiple fiducial markers for Real-time Tumor-tracking Radiation Therapy
Yohei Arai, Hideaki Ueda, Haruo Nakagawa, Naoki Miyamoto, Kikuo Umegaki
第114回医学物理学会, 15 Sep. 2017, English, Oral presentation
大阪, [Domestic Conference] - Evaluation of dosimetric error with utilizing respiratory motion modeling aimed for beam angle optimization in proton beam therapy
Haruo Nakagawa, Naoki Miyamoto, Shusuke Hirayama, Hideaki Ueda, Kohei Yokokawa, Kikuo Umegaki
第114回医学物理学会, 15 Sep. 2017, English, Poster presentation
大阪, [Domestic Conference] - Evaluation of the sensitivity to variable RBE considering LET dependence for the robust optimization and the PTV-based optimization
Shusuke Hirayama, Taeko Matsuura, Hideaki Ueda, Seishin Takao, Hidenori Koyano, Takaaki Fujii, Naoki Miyamoto, Shinichi Shimizu, Yusuke Fujii, Rintaro Fujimoto, Kikuo Umegaki, Hiroki Shirato
第114回医学物理学会, 15 Sep. 2017, English, Oral presentation
大阪, [Domestic Conference] - Evaluation of Water-Equivalent-Thickness (WET) deviation between Plan CT and Re-plan CT for prostate cancer in Spot-Scanning Proton-beam Therapy
Takaaki Fujii, Taeko Matsuura, Seishin Takao, Shusuke Hirayama, Naoki Miyamoto, Kikuo Umegaki, Shinichi Shimizu, Toru Umekawa, Hiroki Shirato
第114回医学物理学会, 15 Sep. 2017, English, Oral presentation
大阪, [Domestic Conference] - Monoscopic X-ray imaging for real-time three-dimensional target localization using multiple internal fiducial markers
Naoki Miyamoto, Ryusuke Suzuki, Seishin Takao, Taeko Matsuura, Takaaki Fujii, Yusuke Hirayama, Hidenori Koyano, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
2017 AAPM Annual Meeting, 30 Jul. 2017, English, Poster presentation
Denver, [International presentation] - Novel 4D-CBCT reconstruction technique for moving target using fiducial-marker position
Takaaki Fujii, Seishin Takao, Taeko Matsuura, Naoki Miyamoto, Shusuke Hirayama, Shinnichi Shimizu, Kikuo Umegaki, Rika Baba, Toru Umekawa, Hiroki Shirato
PTCOG 2017, 08 May 2017, English
Yokohama, [Domestic Conference] - The Retrospective Interplay Effect Evaluation for Real-time Image-gated Proton Therapy using the Fiducial Marker Motion and Treatment Machine Log
Shusuke Hirayama, Taeko Matsuura, Hidenori Koyano, Seishin Takao, Takaaki Fujii, Naoki Miyamoto, Shinichi Shimizu, Yusuke Fujii, Takahiro Yamada, Hideaki Nihongi, Toru Umekawa, Rintaro Fujimoto, Kikuo Umegaki, Hiroki Shirato
第113回医学物理学会, 13 Apr. 2017, Japanese
横浜, [Domestic Conference] - Analysis software to evaluate deviation of water-equivalent thickness along proton beam path between Plan CT and CBCT for proton therapy
Takaaki Fujii, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Shusuke Hirayama, Kikuo Umegaki, Shinichi Shimizu, Toru Umekawa, Rika Baba, Hiroki Shirato
第113回医学物理学会, 13 Apr. 2017, Japanese
横浜, [Domestic Conference] - 体内複数マーカの軌跡データを用いた呼吸による肺の変形の再現性の評価
宮本直樹, 高尾聖心, 松浦妙子, 松崎有華, 鈴木隆介, 井上哲也, 加藤徳雄, 鬼丸力也, 清水伸一, 白土博樹
日本放射線腫瘍学会第29回学術大会, 25 Nov. 2016, Japanese, Oral presentation
京都, [Domestic Conference] - 肺体幹部定位照射中における腫瘍の複雑な動きの解析と動体追跡放射線治療による対策
宮本直樹
日本放射線腫瘍学会第29回学術大会, 25 Nov. 2016, English, Oral presentation
京都, [Invited], [Domestic Conference] - 食道IMRTにおけるintra-fractional organ motionの影響
田村弘詞, 宮本直樹, 鈴木隆介, 堀田賢治, 藤田勝久, 井上哲也
第44回日本放射線技術学会秋期学術大会, 13 Oct. 2016, Japanese
埼玉, [Domestic Conference] - Analysis of Times and Dose Rates for Treating Moving Liver Tumors Using Real-time-image Gated Spot Scanning Proton Beam Therapy System
Shinichi Shimizu, Norio Katoh, Takayuki Hashimoto, Kentaro Nishioka, Takaaki Yoshimura, Seishin Takao, Taeko Matsuura, Naoki Miyamoto, Kikuo Umegaki, Hiroki Shirato
58th ASTRO Annual meeting, 25 Sep. 2016, English
Boston, [International presentation] - Initial Study for the System of Estimating Entrance Skin Dose from X-ray Fluoroscopy during Real-time image Gated Proton Therapy
Yuto Matsuo, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Yuka Matsuzaki, Takaaki Fujii, Shusuke Hirayama, Takaaki Yoshimura, Kikuo Umegaki, Katsuhisa Fujita, Shinichi Shimizu, Hiroki Shirato
第112回医学物理学会, 08 Sep. 2016, Japanese
沖縄, [Domestic Conference] - Modeling of respiratory tumor motion for dosimetric evaluation in proton beam therapy
Haruo Nakagawa, Naoki Miyamoto, Hideaki Ueda, Kohei Yokokawa, Yuka Matsuzaki, Mayuko Nagata, Kikuo Umegaki
第112回医学物理学会, 08 Sep. 2016, Japanese
沖縄, [Domestic Conference] - 動体追跡研究及び４DCBCT研究向け画像解析プラットフォームの開発
藤井孝明, 松浦妙子, 高尾聖心, 宮本直樹, 松崎有華, 平山嵩祐, 清水伸一, 梅垣菊男, 白土博樹
第112回医学物理学会, 08 Sep. 2016, Japanese
沖縄, [Domestic Conference] - Weighted tomographic image reconstruction for time varying object
Satoshi Tomioka, Daiki Naito, Shusuke Nishiyama, Naoki Miyamoto, Kikuo Umegaki
第112回医学物理学会, 08 Sep. 2016, Japanese
沖縄, [Domestic Conference] - 体内マーカ3次元軌跡の解析による呼吸位相評価を利用した動体追跡放射線治療の患者位置決め/ゲート照射の効率化
宮本直樹, 鈴木隆介, 高尾聖心, 松浦妙子, 松崎有華, 藤井孝明, 富岡智, 清水伸一, 梅垣菊男, 白土博樹
第112回医学物理学会, 08 Sep. 2016, Japanese, Oral presentation
沖縄, [Domestic Conference] - Simulation Study of Real-time-image Gating on Spot Scanning Proton Therapy for Lung Tumors
Takahiro Kanehira, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Yusuke Fujii, Takaaki Fujii, Naoki Miyamoto, Tetsuya Inoue, Norio Katoh, Shinichi Shmizu, Kikuo Umegaki, Hiroki Shirato
2016 AAPM Annual Meeting, 31 Jul. 2016, English
Washington DC, [International presentation] - Software development for 4D-CBCTresearchesof Real-time-image gated Spot Scanning Proton Therapy
Takaaki Fujii, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Yuka Matsuzaki, Yusuke Fujii, Kikuo Umegaki, Shinichi Shimizu, Hiroki Shirato
2016 AAPM Annual Meeting, 31 Jul. 2016, English
Washington DC, [International presentation] - An Initial Comparison Study of Motion Interplay Effects between IMPT and SFUD in Liver Real-time-image Gated, Spot-scanning Proton Beam Therapy
Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Yusuke Fujii, Takaaki Fujii, Naoki Miyamoto, Norio Katoh, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki
PTCOG 2016, 22 May 2016, English
Czech, [International presentation] - The evaluation of plan robustness for spot-scanning proton irradiation
Yuka Matsuzaki, Taeko Matsuura, Seishin Takao, Yusuke Fujii, Takaaki Fujii, Naoki Miyamoto, Shinichi Shimizu, Norio Katoh, Kikuo Umegaki, Hiroki Shirato
PTCOG 2016, 22 May 2016, English
Czech, [International presentation] - 陽子線治療装置回転ガントリー搭載型二軸X線撮影装置を用いたCBCT時短撮影の実現可能性検討
高尾聖心, 清水伸一, 宮本直樹, 松浦妙子, 松崎有華, 藤井祐介, 藤井孝明, 梅垣菊男, 白土博樹
第111回医学物理学会, 14 Apr. 2016, Japanese
横浜, [Domestic Conference] - Dual Energy Subtraction 法を用いた動体標的認識技術の基礎検証
藤井孝明, 宮本直樹, 吉村高明, 松尾勇斗, 松浦妙子, 高尾聖心, 松崎有華, 藤井祐介, 梅垣菊男, 清水伸一, 白土博樹
第111回医学物理学会, 14 Apr. 2016, Japanese
横浜, [Domestic Conference] - 肝がんRGPTにおける腫瘍の動き起因の線量誤差比較-SFUD vs. IMPT
松浦妙子, 高尾聖心, 松崎有華, 藤井祐介, 藤井孝明, 宮本直樹, 金平孝博, 加藤徳雄, 清水伸一, 梅垣菊男, 白土博樹
第111回医学物理学会, 14 Apr. 2016, Japanese
横浜, [Domestic Conference] - スポットスキャニング陽子線治療における治療計画のRobustness評価
松崎有華, 松浦妙子, 高尾聖心, 藤井祐介, 藤井孝明, 宮本直樹, 清水伸一, 梅垣菊男, 白土博樹
第111回医学物理学会, 14 Apr. 2016, Japanese
横浜, [Domestic Conference] - 呼吸性移動の複雑さと対策：最新の動体追跡放射線治療
宮本直樹, 高尾聖心, 原田慶一, 石川正純, 鈴木隆介, 松浦妙子, 牧永彩乃, 井上哲也, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹
第2９回日本高精度放射線外部照射研究会, 27 Feb. 2016, Japanese, Nominated symposium
東京, [Invited], [Domestic Conference] - Development of a Real-time-image Gated Proton-beam Therapy (RGPT) system and its Initial Clinical Application to Respiratory Moving Liver Tumors
Shinichi Shimizu, Norio Katoh, Seishin Takao, Taeko Matsuura, Naoki Miyamoto, Takayuki Hashimoto, Kentaro Nishioka, Takaaki Yoshimura, Yuka Matsuzaki, Rumiko Kinoshita, Yukiko Nishikawa, Rikiya Onimaru, Kikuo Umegaki, Hiroki Shirato
57th ASTRO Annual meeting, 18 Oct. 2015, English
San Antonio, [International presentation] - Target Residual Motion During Beam Delivery in Gated Irradiation Using Real-Time Tumor-Tracking Radiotherapy System: Analysis of Simultaneous Motion of Multiple Internal Fiducial Markers
N. Miyamoto, M. Ishikawa, R. Suzuki, A. Makinaga, T. Matsuura, S. Takao, Y. Matsuzaki, T. Inoue, N. Katoh, S. Shimizu, R. Onimaru, H. Shirato
57th ASTRO Annual meeting, 18 Oct. 2015, English, Poster presentation
San Antonio, [International presentation] - Evaluation of treatment time for real-time tumor-tracking radiotherapy
Hiroshi Tamura, Naoki Miyamoto, Ryusuke Suzuki, Kenji Horita, Katsuhisa Fujita
第110回医学物理学会, 18 Sep. 2015, Japanese, Oral presentation
札幌, [Domestic Conference] - International standardization of complex real-time controlled radiotherapy systems for a moving target
Yuichi Hirata, Naoki Miyamoto, Matsuura Taeko, Yusuke Fujii, Kikuo Umegaki, Morihito Shimizu, Yoshiaki Ichikawa, Mitsuhiro Yoshida, Kazuo Hiramoto, Tsuyoshi Sasagawa, Shuji Kaneko, Yutaka Ando, Mitsuhiro Nakamura, Kenji Yokota, Teiji Nishio, Masahiro Hiraoka, Hiroki Shirato
第110回医学物理学会, 18 Sep. 2015, Japanese, Oral presentation
札幌, [Domestic Conference] - Influence of patient repositioning on spot scanning proton therapy for prostate cancer
Yusuke Fujii, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Naoki Miyamoto, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
第110回医学物理学会, 18 Sep. 2015, Japanese, Oral presentation
札幌, [Domestic Conference] - 動体追跡放射線治療の有用性と最新の研究
宮本直樹
第110回医学物理学会, 18 Sep. 2015, Japanese, Nominated symposium
札幌, [Invited], [Domestic Conference] - Influence of the Intrafraction Patient Repositioning On Spot Scanning Proton Therapy for Prostate Cancer
Y Fujii, T Matsuura, S Takao, Y Matsuzaki, T Yamada, N Miyamoto, S Shimizu, K Umegaki, H Shirato
2015 AAPM Annual Meeting, 12 Jul. 2015, English
Anaheim, [International presentation] - Startup Experience of the New Proton Beam Therapy System with Gated Spot Scanning and Real-Time Tumor-Tracking
K Umegaki, T Matsuura, S Takao, Y Matsuzaki, T Yamada, Y Fujii, N Miyamoto, S Shimizu, H Shirato
2015 AAPM Annual Meeting, 12 Jul. 2015, English
Anaheim, [International presentation] - Development of An Applicator for Treating Shallow and Moving Tumors with Respiratory-Gated Spot-Scanning Proton Therapy Using Real-Time Image Guidance
T Matsuura, Y Fujii, S Takao, T Yamada, Y Matsuzaki, N Miyamoto, T Takayanagi, S Fujitaka, S Shimizu, H Shirato, K Umegaki
2015 AAPM Annual Meeting, 12 Jul. 2015, English
Anaheim, [International presentation] - Development of Evaluation System of Optimal Synchrotron Controlling Parameter for Spot Scanning Proton Therapy with Multiple Gate Irradiations in One Operation Cycle
T Yamada, N Miyamoto, T Matsuura, S Takao, Y Matsuzaki, Y Fujii, H Koyano, H Nihongi, M Umezawa, K Matsuda, K Umegaki, H Shirato
2015 AAPM Annual Meeting, 12 Jul. 2015, English
Anaheim, [International presentation] - Development and Commissioning of Real-Time Imaging Function for Respiratory-Gated Spot-Scanning Proton Beam Therapy
N Miyamoto, S Takao, T Matsuura, Y Matsuzaki, T Yamada, Y Fujii, Y Matsuo, T Kidani, Y Egashira, T Umekawa, S Shimizu, H Shirato, K Umegaki
2015 AAPM Annual Meeting, 12 Jul. 2015, English, Oral presentation
Anaheim, [International presentation] - Commissioning & QA for SyncTraX for SRS
Naoki Miyamoto, Masayori Ishikawa, Ryusuke Suzuki, Hiroshi Tamura, Katsuhisa Fujita, Tetsuya Inoue, Norio Katoh, Shinichi Shimizu, Rikiya Onimaru, Hiroki Shirato
12th International Stereotactic Radiosurgery Society Congress, 07 Jun. 2015, English, Nominated symposium
Yokohama, [Invited], [Domestic Conference] - Feasibility of fast cone-beam CT image acquisition with a dual-orthogonal fluoroscopic imaging system equipped on rotating gantry of proton beam therapy system
Seishin Takao, Shinichi Shimizu, Takahiro Yamada, Naoki Miyamoto, Taeko Matsuura, Yuka Matsuzaki, Yusuke Fujii, Toru Umekawa, Rika Baba, Kikuo Umegaki, Hiroki Shirato
54th PTCOG, 18 May 2015, English
San Diego, [International presentation] - The Establishment of Patient-specific QA for Spot-Scanning Proton Beam Irradiation System at Hokkaido University
Yuka Matsuzaki, Taeko Matsuura, Seishin Takao, Takahiro Yamada, Yusuke Fujii, Naoki Miyamoto, Yuto Matsuo, Takaaki Yoshimura, Kikuo Umegaki, Hiroki Shirato
54th PTCOG, 18 May 2015, English
San Diego, [International presentation] - Startup experience of gated spot scanning proton beam therapy system with real-time tumor-tracking
Kikuo Umegaki, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Naoki Miyamoto, Takahiro Yamada, Yusuke Fujii, Shinichi Shimizu, Hiroki Shirato
54th PTCOG, 18 May 2015, English
San Diego, [International presentation] - Machine QA for Spot-Scanning Proton Beam Irradiation System at Hokkaido University
Takahiro Yamada, Yuka Matsuzaki, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Yuto Matsuo, Takaaki Yoshimura, Kikuo Umegaki, Hiroki Shirato
54th PTCOG, 18 May 2015, English
San Diego, [International presentation] - Commissioning of the on-board cone-beam CT system equipped on the rotating gantry of a proton beam therapy system
Takao S, Shimizu S, Miyamoto N, Matsuura T, Matsuzaki Y, Yamada T, Fujii Y, Matsuo Y, Umegaki K, Shirato H
第109回医学物理学会, 16 Apr. 2015, Japanese
横浜, [Domestic Conference] - Development of a short range applicator for real-time-image gated proton beam therapy
Taeko Matsuura, Yusuke Fujii, Seishin Takao, Yuka Matsuzaki, Takahiro Yamada, Naoki Miyamoto, Yuto Matsuo, Shinichiro Fujitaka, Tisuke Takayanagi, Kikuo Umegaki, Hiroki Shirato
第109回医学物理学会, 16 Apr. 2015, Japanese
横浜, [Domestic Conference] - 体内マーカー運動に基づく呼吸位相評価法の開発と待ち伏せ照射の高精度化への応用
宮本直樹, 石川正純, 鈴木隆介, 高尾聖心, 松浦妙子, 平田雄一, 加藤徳雄, 清水伸一, 梅垣菊男, 白土博樹
第109回医学物理学会, 16 Apr. 2015, Japanese, Oral presentation
横浜, [Domestic Conference] - 北海道大学病院陽子線治療センターの動体追跡装置のコミッショニング
宮本直樹, 高尾聖心, 松浦妙子, 松崎有華, 山田貴啓, 藤井祐介, 松尾勇斗, 清水伸一, 梅垣菊男, 白土博樹
第109回医学物理学会, 16 Apr. 2015, Japanese, Oral presentation
横浜, [Domestic Conference] - 体追跡放射線治療システムの臨床応用と今後の展望
宮本直樹, 石川正純, 井上哲也, 加藤徳雄, 清水伸一, 鬼丸力也
日本放射線腫瘍学会第27回学術大会, 11 Dec. 2014, Japanese, Nominated symposium
横浜, [Invited], [Domestic Conference] - Validation of treatment planning system of a spot-scanning proton therapy at Hokkaido University
Takahiro Yamada, Taeko Matsuura, Chie Toramatsu, Seishin Takao, Naoki Miyamoto, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
7th Korea-Japan Meeting on Medical Physics, 25 Sep. 2014, Poster presentation
Busan, Korea, [International presentation] - Quality control of a next generation Realtime tumor tracking radiotherapy system
Suguru Kimura, Naoki Miyamoto, Kenneth Sutherland, Ryusuke Suzuki, Hiroki Shirato, Masayori Ishikawa
7th Korea-Japan Meeting on Medical Physics, 25 Sep. 2014, Poster presentation
Busan, Korea, [International presentation] - Fundamental study of a new gating irradiation method in Real-Time tumor tracking radiotherapy (RTRT) system by using multiple internal fiducial marker
Kanako Otomo, Naoki Miyamoto, Masayori Ishikawa, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Rikiya Onimaru, Shinichirou Shimizu, Hiroki Shirato
7th Korea-Japan Meeting on Medical Physics, 25 Sep. 2014, Poster presentation
Busan, Korea, [International presentation] - Dosimetric evaluation of the moving target in beam gating irradiation system
Naoki Miyamoto, Masayori Ishikawa, Ryusuke Suzuki, Yuichi Hirata, Tsuyoshi Sasagawa, Seiji Yamanaka, Hiroshi Tamura, Katsuhisa Fujita, Tetsuya Inoue, Norio Katoh, Hiroki Shirato
7th Korea-Japan Meeting on Medical Physics, 25 Sep. 2014, Oral presentation
Busan, Korea, [International presentation] - Validation of beam accuracy of a gated spot-scanning proton therapy system with real-time tumor-tracking at Hokkaido University
Takahiro Yamada, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Chie Toramatsu, Shinichi Shimizu, Hideaki Nihongi, Taisuke Takayanagi, Masumi Umezawa, Koji Matsuda, Kikuo Umegaki, Hiroki Shirato
AAPM 56th Annual Meeting,, 20 Jul. 2014, Poster presentation
Austin, [International presentation] - Commissioning of the On-board Cone-beam CT System Equipped on the Rotating Gantry of a Proton Therapy System
Takao S, Shimizu S, Miyamoto N, Matsuura T, Toramatsu C, Nihongi H, Yamada T, Matsuda K, Sasaki T, Nagamine Y, Baba R, Umekawa T, Umegaki K, Shirato H
AAPM 56th Annual Meeting,, 20 Jul. 2014, Poster presentation
Austin, [International presentation] - A real-time patient positioning and monitoring system utilizing fluoroscopy
Kenneth Sutherland, Naoki Miyamoto, Hiroki Shirato
CARS 2014, 25 Jun. 2014, Poster presentation
Fukuoka, [International presentation] - Clinical Commissioning of Hokkaido University Hospital Proton Therapy Center
Chie Toramatsu, Taeko Matsuura, Seishin Takao, Hideaki Nihongi, Takahiro Yamada, Naoki Miyamoto, Kikuo Umegaki, Rumiko Kinoshita, Shinichi Shimizu, Hiroki Shirato
PTCOG 53, 08 Jun. 2014, Poster presentation
Shanghai, [International presentation] - Validation of beam performance of a new spot-scanning proton therapy system at Hokkaido University
Takahiro Yamada, Chie Toramatsu, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Hideaki Nihongi, Masumi Umezawa, Koji Matsuda, Kikuo Umegaki, Shinichi Shimizu, Hiroki Shirato
PTCOG 53, 08 Jun. 2014, Poster presentation
Shanghai, [International presentation] - 北海道大学における分子追跡放射線治療装置のビーム性能の検証
二本木英明, 寅松千枝, 松浦妙子, 高尾聖心, 宮本直樹, 山田貴啓, 清水伸一, 梅垣菊男, 白土博樹, 松田浩二, 梅澤真澄
第107回医学物理学会, 10 Apr. 2014, Oral presentation
横浜, [Domestic Conference] - 北海道大学病院陽子線治療センターのクリニカルコミッショニング
寅松千枝, 松浦妙子, 高尾聖心, 二本木英明, 山田貴啓, 宮本直樹, 清水伸一, 梅垣菊男, 白土博樹
第107回医学物理学会, 10 Apr. 2014, Oral presentation
横浜, [Domestic Conference] - 次世代動体追跡装置のアクセプタンス/コミッショニング
石川 正純, 宮本 直樹, 篠川 毅, 山中 誓次, 堀田 賢治, 藤田 勝久, 鈴 木隆介, 鬼丸 力也, 井上 哲也, 白土 博樹
第107回医学物理学会, 10 Apr. 2014, Oral presentation
横浜, [Domestic Conference] - Development of a dynamic phantom for quality control in 4D radiotherapy
Naoki Miyamoto, Yuichi Hirata, Ryusuke Suzuki, Chie Toramatsu, Yuki Miyabe, Shuji Kaneko, Teiji Nishio, Shinichi Shimizu, Masayori Ishikawa, Hiroki Shirato
第107回医学物理学会, 10 Apr. 2014, Oral presentation
横浜, [Domestic Conference] - 3点の体内マーカーを用いた患者セットアップの有効性評価
加藤英斗, 宮本直樹, 大友加奈子, 鈴木隆介, 西岡健太郎, 清水伸一, 鬼丸力也, 石川正純, 白土博樹
第27回日本高精度外部照射研究会, 22 Feb. 2014, Poster presentation
東京, [Domestic Conference] - 次世代型RTRT：SyncTraXの開発から臨床応用へ
宮本直樹, 石川正純, 井上哲也, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹
第27回日本高精度外部照射研究会, 22 Feb. 2014, Nominated symposium
東京, [Invited], [Domestic Conference] - Development of a dynamic phantom for quality control in 4D radiotherapy
Naoki Miyamoto, Yuichi Hirata, Ryusuke Suzuki, Chie Toramatsu, Takashi Kozuka, Yuki Miyabe, Shuji Kaneko, Teiji Nishio, Shinichi Shimizu, Masayori Ishikawa, Hiroki Shirato
4D (Treatment Planning) workshop, 28 Nov. 2013, Poster presentation
Switzerland, [International presentation] - Evaluation of the measurement accuracy of a novel monoscopic x-ray imaging system for real-time tumor-tracking radiotherapy
Naoki Miyamoto, Masayori Ishikawa, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Seishin Takao, Chie Toramatsu, Hideaki Nihongi, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
4D (Treatment Planning) workshop, 28 Nov. 2013, Poster presentation
Switzerland, [International presentation] - 動体追跡装置における透視X線による患者被ばく線量の評価
木村傑, 宮本直樹, 鈴木隆介, 石川正純, 寅松千枝, 松浦妙子, 高尾聖心, 白土博樹
第106回医学物理学会, 18 Oct. 2013, Poster presentation
大阪, [Domestic Conference] - 陽子線治療が求められる腫瘍体積
寅松千枝, 加藤徳雄, 清水伸一, 二本木英明, 松浦妙子, 高尾聖心, 宮本直樹, 鈴木隆介, 木下留美子, 鬼丸力也, 石川正純, 梅垣菊男, 白土博樹
日本放射線腫瘍学会第26回学術大会, 18 Oct. 2013, Oral presentation
青森, [Domestic Conference] - 動体迎撃照射の現状と未来
宮本直樹
日本放射線腫瘍学会第26回学術大会, 18 Oct. 2013, Japanese, Nominated symposium
青森, [Invited], [Domestic Conference] - Baseline shift of intrafractional lung tumor motion in the real-time tumor-tracking radiotherapy
Seishin Takao, Naoki Miyamoto, Taeko Matsuura, Shinichi Shimizu, Rikiya Onimaru, Norio Katoh, Tetsuya Inoue, Hiroki Shirato
55th ASTRO Annual Meeting, 22 Sep. 2013, Oral presentation
Atlanta, [International presentation] - Can 4D CT Imaging Predict Lung Motion During Stereotactic Body Radiation Therapy?
K. Harada, N. Katoh, R. Suzuki, T. Inoue, R. Onimaru, S. Shimizu, N. Miyamoto, M.Ishikawa, H. Shirato
55th ASTRO Annual Meeting, 22 Sep. 2013, Oral presentation
Atlanta, [International presentation] - Conformal Therapy (ECT) and Spot Scanning Proton Therapy for Post-mastectomy Chest Wall Irradiation
Chie Toramatsu, Shinichi Shimizu, Taeko Matsuura, Naoki Miyamoto, Rumiko Kinoshita, Seishin Takao, Hideaki Nihongi, Kikuo Umegaki, Hiroki Shirato
55th ASTRO Annual Meeting, 22 Sep. 2013, Poster presentation
Atlanta, [International presentation] - Simulation of spot scanning proton-beam therapy for moving targets - using organ motion log data gathered with the RTRT system
S. Shimizu, T. Matsuura, N. Katoh, R. Kinoshita, S. Onodera, R. Onimaru, N. Miyamoto, C. Toramatsu, S. Takao, H. Nihongi, R. Fujimoto, Y. Nagamine, M. Umezawa, K. Hiramoto, K. Umegaki, H. Shirato
PTCOG 52, 02 Jun. 2013, Poster presentation
Germany, [International presentation] - Baseline shift of intrafractional lung tumor motion in the real-time tumor-tracking radiotherapy
Seishin Takao, Shinichi Shimizu, Naoki Miyamoto, Taeko Matsuura, Chie Toramatsu, Hideaki Nihongi, Kikuo Umegaki, Hiroki Shirato
PTCOG 52, 02 Jun. 2013, Poster presentation
Germany, [International presentation] - Development of the device for Spot-scanning proton irradiation to shallow seated tumor
Chie Toramatsu, Rikiya Onimaru, Shinichi Shimizu, Taeko Matsuura, Naoki Miyamoto, Rumiko Kinoshita, Seishin Takao, Hideaki Nihongi, Kikuo Umegaki, Hiroki Shirato, Rintaro Fujimoto, Shunsuke Hirayama, Yusuke Fujii, Taisuke Takayanagi, Masumi Umezasa, Koji Matsuda, Yoshihiko Nagamine
PTCOG 52, 02 Jun. 2013, Poster presentation
Germany, [International presentation] - Real-time tumor-tracking radiotherapy system with mono X-ray fluoroscopy
Naoki Miyamoto, Masayori Ishikawa, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Seishin Takao, Chie Toramatsu, Hideaki Nihongi, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
第105回医学物理学会, 11 Apr. 2013, Oral presentation
横浜, [Domestic Conference] - A study on a gated proton spot-scanning beam therapy integrated with a real-time tumor-monitoring: an initial phantom study using patient tumor trajectory data
Taeko Matsuura, Naoki Miyamoto, Shinichi Shimizu, Yusuke Fujii, Masumi Umezawa, Seishin Takao, Hideaki Nihongi, Chie Toramatsu, Kikuo Umegaki, Hiroki Shirato
第105回医学物理学会, 11 Apr. 2013, Oral presentation
横浜, [Domestic Conference] - 照射中と4DCT撮影時の肺内マーカ移動の比較
原田慶一, 加藤徳男, 鈴木隆介, 井上哲也, 鬼丸力也, 清水伸一, 宮本直樹, 石川正純, 白土博樹
第26回日本高精度放射線外部照射研究会, 23 Feb. 2013
京都 - Progress report on collaborative development activities in improvement of spot-scanning proton therapy system Simulation of spot-scanning proton-beam therapy to the moving target using organ motion log-data obtained by an RTRT system
Chie Toramatsu, Rintaro Fujimoto, Rikiya Onimaru, Shinichi Shimizu, Taeko Matsuura, Naoki Miyamoto, Rumiko Kinoshita, Seishin Takao, Hideaki Nihongi, Kikuo Umegaki, Hiroki Shirato, Shunsuke Hirayama, Yusuke Fujii, Taisuke Takayanagi, Masumi Umezawa, Koji Matsuda, Yoshihiko Nagamine
Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique, 07 Feb. 2013, Poster presentation
Sapporo, [International presentation] - Simulation of spot-scanning proton-beam therapy to the moving target using organ motion log-data obtained by an RTRT system
Shinichi Shimizu, Taeko Matsuura, Norio Katoh, Rumiko Kinoshita, Shunsuke Onodera, Rikiya Onimaru, Naoki Miyamoto, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Rintaro Fujimoto, Yoshihiko Nagamine, Masumi Umezawa, Kazuo Hiramoto, Kikuo Umegaki, Hiroki Shirato
Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique, 07 Feb. 2013, Poster presentation
Sapporo, [International presentation] - A study on a gated proton spot-scanning beam therapy integrated with a real-time tumor-monitoring: an initial phantom study using patient tumor trajectory data
Taeko Matsuura, Naoki Miyamoto, Shinichi Shimizu, Yusuke Fujii, Masumi Umezawa, Seishin Takao, Hideaki Nihongi, Chie Toramatsu, Kenneth Sutherland, Kikuo Umegaki, Hiroki Shirato
Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique, 07 Feb. 2013, Poster presentation
Sapporo, [International presentation] - Preparation of Manuals for Treatment Planning at Hokkaido University
Nihongi H, Toramatsu C, Matsuura T, Takao S, Miyamoto N, Umegaki K, Shimizu S, Kinoshita R, Onodera S, Shirato H
Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique, 07 Feb. 2013, Poster presentation
Sapporo, [International presentation] - Development of dynamic phantom for safety management in four-dimensional radiotherapy
Naoki Miyamoto, Yuichi Hirata, Ryusuke Suzuki, Chie Toramatsu, Satoru Utsunomiya, Mitsuhiro Nakamura, Yuki Miyabe, Teiji Nishio, Takashi Kozuka, Shuji Kaneko, Takashi Mizowaki, Shinichic Shimizu, Masayori Ishikawa, Masahiro Hiraoka, Hiroki Shirato
Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique, 07 Feb. 2013, Poster presentation
Sapporo, [International presentation] - The Role of Spot Scanning Proton Therapy in the Treatment of Large tumors:A Comparative Planning Study of Hepatocellular Carcinoma
Toramatsu C, Katoh N, Shimizu S, Nihongi H, Matsuura T, Takao S, Miyamoto N, Kinoshita R, Umegaki K, Shirato H
54th ASTRO Annual Meeting, 28 Oct. 2012, Poster presentation
Boston, [International presentation] - 北海道大学における分子追跡陽子線治療装置
二本木英明, 寅松千枝, 松浦妙子, 高尾聖心, 宮本直樹, 梅垣菊男, 清水伸一, 木下留美子, 小野寺俊輔, 白土博樹, 松田浩二, 梅澤真澄, 平本和夫
第9回日本粒子線治療臨床研究会, 13 Oct. 2012
指宿 - 一方向X線透視による低被曝･省スペース型動体追跡装置の開発
宮本直樹, 石川正純, Kenneth Sutherland, 鈴木隆介, 松浦妙子, 高尾聖心, 寅松千枝, 二本木英明, 清水伸一, 梅垣菊男, 白土博樹
第104回医学物理学会, 01 Sep. 2012
つくば - 陽子線治療における最適な治療ワークフローの検討
高尾聖心, 松浦妙子, 寅松千枝, 二本木英明, 宮本直樹, 清水伸一, 木下留美子, 松田浩二, 木谷貴雄, 梅垣菊男, 白土博樹
第104回医学物理学会, 01 Sep. 2012
つくば - 複数体内マーカを利用した腫瘍の呼吸性運動の詳細解析とゲーティング照射の有用性の検討
大友可奈子, 宮本直樹, 石川正純, Kenneth Sutherland, 鈴木隆介, 松浦妙子, 鬼丸力也, 清水伸一, 梅垣菊男, 白土博樹
第104回医学物理学会, 01 Sep. 2012
つくば - Accelerated Computation of Digitally Reconstructed Radiographs with a GPU
Kenneth Sutherland, 宮本直樹, 石川正純, 鈴木隆介, 白土博樹
第104回医学物理学会, 01 Sep. 2012
つくば - 陽子線スキャニング照射における体内マーカーによる線量遮蔽のTCPを用いた評価
前田憲一郎, 松浦妙子, Kenneth Sutherland, 高尾聖心, 寅松千枝, 二本木英明, 宮本直樹, 清水伸一, 石川正純, 梅垣菊男, 白土博樹
第104回医学物理学会, 01 Sep. 2012
つくば - Development of The Compact Proton Beam Therapy System Dedicated to Spot Scanning with Real-time Tumor-tracking Technology
Umezawa M, Fujimoto R, Umekawa T, Fujii Y, Takayanagi T, Ebina F, Aoki T, Nagamine Y, Matsuda K, Hiramoto K, Matsuura T, Miyamoto N, Nihongi H, Umegaki K, iShirato H
22nd International Conference on the Application of Accelerators in Research and Industry, 05 Aug. 2012, Poster presentation
Texas, [International presentation] - Motion adaptive image filter for low dose X-ray fluoroscopy in real-time tumor-tracking radiotherapy system
Naoki Miyamoto, Masayori Ishikawa, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Seishin Takao, Chie Toramatsu, Hideaki Nihongi, Shinichi Shimizu, Rikiya Onimaru, Kikuo Umegaki, Hiroki Shirato
AAPM 54th Annual Meeting,, 29 Jul. 2012, Poster presentation
Charlotte, [International presentation] - Biological Effect of Dose Shadowing by Fiducial Markers in Spot Scanning Proton Therapy with a Limited Number of Fields
T Matsuura, K Maeda, K Sutherland, T Takayanagi, S Shimizu, S Takao, H Nihongi, C Toramatsu, N Miyamoto, Y Nagamine, R Fujimoto, K Umegaki, H Shirato
AAPM 54th Annual Meeting,, 29 Jul. 2012, Poster presentation
Charlotte, [International presentation] - Dosimetric Study for Shallow-Seated Tumor Using Passive/active Scanning Proton Beam
C Toramatsu, T Matsuura, H Nihongi, S Takao, N Miyamoto, S Shimizu, R Kinoshita, K Umegaki, H Shirato
AAPM 54th Annual Meeting,, 29 Jul. 2012, Poster presentation
Charlotte, [International presentation] - DEVELOPMENT OF DYNAMIC PHANTOM FOR QUALITY CONTROL IN FOUR-DIMENSIONAL RADIOTHERAPY
Naoki Miyamoto, Yuichi Hirata, Kenji Naoe, Ryusuke Suzuki, Chie Toramatsu, Shinichi Shimizu, Yuki Miyabe, Shuji Kaneko, Teiji Nishio, Masayori Ishikawa, Masahiro Hiraoka, Hiroki Shirato
31th Sapporo International Cancer Symposium, 23 Jul. 2012, Poster presentation
Sapporo, [International presentation] - Spot-scanning Proton Therapy for Mobile Tumors -Reduction of Interplay Effect by Gating Technique-
Taeko Matsuura, Naoki Miyamoto, Shinichi Shimizu, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Rumiko Kinoshita, Rikiya Onimaru, Masumi Umezawa, Rintaro Fujimoto, Koji Matsuda, Kikuo Umegaki, Hiroki Shirato
31th Sapporo International Cancer Symposium, 23 Jul. 2012, Poster presentation
Sapporo, [International presentation] - Usability of Treatment Procedure in Spot Scanning Proton Beam Therapy System
Seishin Takao, Shinichi Shimizu, Taeko Matsuura, Chie Toramatsu, Hideaki Nihongi, Naoki Miyamoto, Koji Matsuda, Toru Umekawa, Kikuo Umegaki, Hiroki Shirato
31th Sapporo International Cancer Symposium, 23 Jul. 2012, Poster presentation
Sapporo, [International presentation] - A Comparative Planning Study of Large abdominal tumors _ The role of Proton Therapy in the Treatment of Large Irradiation Volumes
Chie Toramatsu, Hideaki Nihongi, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Kikuo Umegaki, Norio Katoh, Shinichi Shimizu, Rumiko Kinoshita, Hiroki Shirato
31th Sapporo International Cancer Symposium, 23 Jul. 2012, Poster presentation
Sapporo, [International presentation] - PREPARATION FOR A PROTON SCANNING TREATMENT PLANNING SYSTEM AT HOKKDAIDO UNIVERSITY
Hideaki Nihongi, Chie Toramatsu, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Kikuo Umegaki, Shinichi Shimizu, Rumiko Kinoshita, Shunsuke Onodera, Hiroki Shirato
31th Sapporo International Cancer Symposium, 23 Jul. 2012, Poster presentation
Sapporo, [International presentation] - Web-based database system for inter-fractional organ motion estimated by real-time tumor-tracking radiotherapy system
Ryusuke Suzuki, Masayori Ishikawa, Naoki Miyamoto, Kenneth Lee Sutherland, Taeko Matsuura, Seishin Takao, Chie Toramatsu, Hideaki Nihongi, Shinichi Shimizu, Rikiya Onimaru, Hiroki Shirato
31th Sapporo International Cancer Symposium, 23 Jul. 2012, Poster presentation
Sapporo, [International presentation] - Development of international standardization of Four Dimensional Radiotherapy
Yuichi Hirata, Takashi Kozuka, Kenji Naoe, Naoki Miyamoto, Chie Toramatsu, Ryusuke Suzuki, Shinichi Shimizu, Yuki Miyabe, Shuji Kaneko, Takashi Mizowaki, Masahiro Hiraoka, Mitsuhiro Yoshida, Kazuo Hiramoto, Tsuyoshi Sasagawa, Hiroki Shirato
31th Sapporo International Cancer Symposium, 23 Jul. 2012, Poster presentation
Sapporo, [International presentation] - Motion adaptive image filter for low dose X-ray fluoroscopy in real-time tumor-tracking radiotherapy system
Naoki Miyamoto, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Rumiko Kinoshita, Shinichi Shimizu, Rikiya Onimaru, Kikuo Umegaki, Hiroki Shirato, Masayori Ishikawa
The 6th S. Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, 19 Jul. 2012, Poster presentation
Hiroshima, [International presentation] - Development of the Compact Proton Beam Therapy System Dedicated to Spot Scanning with Real Time Tumor Tracking Technology
Yusuke Fujii, Futaro Ebina, Rintaro Fujimoto, Masumi Umezawa, Kazuo Hiramoto, Yoshihiko Nagamine, Koji Matsuda, Taeko Matsuura, Naoki Miyamoto, Hideaki Nihongi, Kikuo Umegaki, Hiroki Shirato
The 6th S. Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, 19 Jul. 2012, Poster presentation
Hiroshima, [International presentation] - Development of Spot Scanning Proton Beam Therapy System with Real-Time Tumor-Tracking Technology
Hiroki Shirato, Kikuo Umegaki, Shinichi Shimizu, Taeko Matsuura, Naoki Miyamoto, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Kazuo Hiramoto, Fumito Nakamura
PTCOG 51, 17 May 2012, Invited oral presentation
Seoul, Korea, [International presentation] - On reduction of irradiation time in Real-time Tumor-tracking Proton beam Therapy
Taeko Matsuura, Naoki Miyamoto, Shinichi Shimizu, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Masumi Umezawa, Yusuke Fujii, Kikuo Umegaki, Hiroki Shirato
PTCOG 51, 17 May 2012, Poster presentation
Seoul, Korea, [International presentation] - Design of treatment workflow in proton therapy system with compact rotating gantry
Seishin Takao, Shinichi Shimizu, Chie Toramatsu, Taeko Matsuura, Hideaki Nihongi, Naoki Miyamoto, Koji Matsuda, Toru Umekawa, Kikuo Umegaki, Hiroki Shirato
PTCOG 51, 17 May 2012, Poster presentation
Seoul, Korea, [International presentation] - A Comparative Planning Study of Large abdominal tumors
Toramatsu C, Katoh N, Shimizu S, Nihongi H, Matsuura T, Takao S, Miyamoto N, Kinoshita R, Umegaki K, Shirato H
PTCOG 51, 17 May 2012, Poster presentation
Seoul, Korea, [International presentation] - Performance and dose distribution evaluation of scanning dedicated compact proton therapy system by treatment planning simulation
Hideaki Nihongi, Chie Toramatsu, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Kikuo Umegaki, Shinichi Shimizu, Rumiko Kinoshita, Hiroki Shirato
PTCOG 51, 17 May 2012, Poster presentation
Seoul, Korea, [International presentation] - Accuracy Verification of the Marker Tracking System Mounted on the Rotating Gantry
Toru Umekawa, Takao Kidani, Toshie Sasaki, Yoshihiko Nagamine, Masumi Umezawa, Kazuo Hiramoto, Naoki Miyamoto, Seishin Takao, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
PTCOG 51, 17 May 2012, Poster presentation
Seoul, Korea, [International presentation] - Dose distribution analysis of moving target irradiated by proton spot scanning combined with gating technique
Yusuke Fujii, Toru Umekawa, Rintaro Fujimoto, Yoshihiko Nagamine, Masumi Umezawa, Kazuo Hiramoto, Hiroshi Akiyama, Naoki Miyamoto, Taeko Matsuura, Kikuo Umegaki, Hiroki Shirato
PTCOG 51, 17 May 2012, Poster presentation
Seoul, Korea, [International presentation] - 高精度X線治療機器の開発
宮本直樹
第51回日本生体医工学会大会, 10 May 2012, Japanese, Nominated symposium
福岡, [Invited], [Domestic Conference] - 治療計画シミュレーションによる陽子線スキャニング専用機の線量分布の検証
二本木英明, 寅松千枝, 松浦妙子, 高尾聖心, 宮本直樹, 梅垣菊男, 清水伸一, 木下留美子, 白土博樹
第103回医学物理学会, 12 Apr. 2012
横浜 - フリームービング条件下における時計遺伝子発現の新規非侵襲 4D イメージング
浜田俊幸, 本間さと, Kenneth Sutherland, 宮本直樹, 石川正純, 白土博樹, 本間研一
第89回日本生理学会大会, 29 Mar. 2012
長野 - IGRT and Real time 4DRT with RTRT
Shimizu S, Onimaru R, Kinoshita R, Kato N, Inoue T, Nishioka K, Matsuura T, Miyamoto N, Kenneth Sutherland, Toramatsu C, Takao S, Nihongi H, Umegaki K, Shirato H
Second International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique, 16 Feb. 2012, Oral presentation
Kyoto, [International presentation] - Real-time Tumor-tracking Radiotherapy (RTRT) for Non-smoll Cell Lung Cancer(NSCLC)
Onimaru R, Shimizu S, Kinoshita R, Kato N, Inoue T, Nishioka K, Matsuura T, Miyamoto N, Kenneth Sutherland, Toramatsu C, Takao S, Nihongi H, Umegaki K, Shirato H
Second International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique, 16 Feb. 2012, Oral presentation
Kyoto, [International presentation] - Progress Report on Collaborative Research Activities in RTPT I-Synchrotron-based Compact Proton Therapy System Dedicated to Spot Scanning-
Umezawa M, Fujimoto R, Umekawa T, Fujii Y, Takayanagi T, Ebina F, Aoki T, Nagamine Y, Matsuda K, Hiramoto K, Matsuura T, Miyamoto N, Nihongi H, Umegaki K, Shirato H
Second International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique, 16 Feb. 2012, Oral presentation
Kyoto, [International presentation] - Progress Report on Collaborative Research Activities in RTPT II -Integration of RTRT and Spot Scanning Proton Therapy-
Matsuura T, Miyamoto N, Kenneth Sutherland, Toramatsu C, Takao S, Nihongi H, Shimizu S, Kinoshita R, Onimaru R, Umezawa M, Fujimoto R, Hiramoto K, Nagamine Y, Matsuda K, Umegaki K, Shirato H
Second International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique, 16 Feb. 2012, Oral presentation
Kyoto, [International presentation] - 分子イメージング画像を用いた高精度画像誘導放射線治療
石川正純, 山口哲, 棚邊哲史, 山中琢, 宮本直樹, 鈴木隆介, Kenneth Sutherland, 加藤徳雄, 白土博樹
第24回日本高精度放射線外部照射研究会, 04 Feb. 2012
横浜 - Improvement of tracking accuracy and stability by recursive image processing in real-time tumor-tracking radiotherapy system
Naoki Miyamoto, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Rumiko Kinoshita, Shinichi Shimizu, Rikiya Onimaru, Kikuo Umegaki, Hiroki Shirato, Masayori Ishikawa
SPIE Medical Imaging, 04 Feb. 2012, Oral presentation
San Diego, [International presentation] - マルチベンダ環境における放射線治療情報統合・照合システムの構築
鈴木隆介, 安田耕一, 藤田勝久, 辻真太郎, 宮崎智夫, 石川正純, 宮本直樹, 望月健太, 清水伸一, 白土博樹
日本放射線腫瘍学会, 17 Nov. 2011
神戸 - 複数体内マーカを利用した腫瘍の呼吸性運動の詳細解析とゲーティング照射の有用性の検討
大友可奈子, 宮本直樹, 石川正純, Kenneth Sutherland, 鈴木隆介, 松浦妙子, 鬼丸力也, 清水伸一, 梅垣菊男, 白土博樹
日本放射線腫瘍学会, 17 Nov. 2011
神戸 - 線量分布検証における誤差の要因と判定基準に関する考察
石川正純, Kenneth Sutherland, 峯村俊行, 棚邊哲史, 遠山尚紀, 成田雄一郎, 西尾禎治, 宮本直樹, 鈴木隆介, 石倉聡
日本放射線腫瘍学会, 17 Nov. 2011
神戸 - Notable achievements and future vision of the real-time tumor-tracking radiotherapy system
Naoki Miyamoto
6-th JKMP 11-th AOCMP, 29 Sep. 2011, English, Invited oral presentation
Fukuoka, [Invited], [International presentation] - Respiratory motion of lung tumor determined by trajectory data of multiple fiducial markers in real-time tumor-tracking radiotherapy
Naoki Miyamoto, Kanako Otomo, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Chie Toramatsu, Seishin Tako, Hideaki Nihongi, Rumiko Kinoshita, Shinichi Shimizu, Rikiya Onimaru, Masayori Ishikawa, Kikuo Umegaki, Hiroki Shirato
6-th JKMP 11-th AOCMP, 29 Sep. 2011, Poster presentation
Fukuoka, [International presentation] - The initial evaluation of irradiation time and motion dose errors in Real-time Tumor-Tracking Proton Beam Therapy
Taeko Matsuura, Naoki Miyamoto, Kenneth Sutherland, Chie Toramatsu, Seishin Tako, Hideaki Nihongi, Shinichi Shimizu, Rumiko Kinoshita, Rikiya Onimaru, Yusuke Fujii, Taisuke Takayanagi, Rintaro Fujimoto, Yoshihiko Nagamine, Kikuo Umegaki, Hiroki Shirato
6-th JKMP 11-th AOCMP, 29 Sep. 2011, Oral presentation
Fukuoka, [International presentation] - A feasibility study on molecular-guided radiotherapy using a parallel plane PET
Masayori Ishikawa, Satoshi Yamaguchi, Satoshi Tanabe, Kenneth Sutherland, Naoki Miyamoto, Ryusuke Suzuki, Hiroki Shirato
6-th JKMP 11-th AOCMP, 29 Sep. 2011, Oral presentation
Fukuoka, [International presentation] - 陽子線治療計画装置とX線治療計画の環境構築
清水伸一, 木下留美子, 鬼丸力也, 白土博樹, 二本木英明, 寅松千枝, 松浦妙子, 高尾聖心, 宮本直樹, 梅垣菊男
第8回日本粒子線治療臨床研究会, 23 Sep. 2011
群馬 - 分子追跡陽子線治療装置の開発
梅垣菊男, 寅松千枝, 松浦妙子, 高尾聖心, 二本木英明, 宮本直樹, 清水伸一, 木下留美子, 鬼丸力也, 白土博樹
第8回日本粒子線治療臨床研究会, 23 Sep. 2011
群馬 - 複数マーカを利用したゲーティング照射における照射効率に関する検討
大友可奈子, 宮本直樹, 石川正純, Kenneth Sutherland, 鈴木隆介, Gerard Bengua, 松浦妙子, 鬼丸力也, 清水伸一, 白土博樹
第101回日本医学物理学会, 09 May 2011
Web - 陽子線スキャニングビームにおける偏向磁場による線量分布の形状変化に関する考察
前田憲一郎, Kenneth Sutherland, 松浦妙子, 石川正純, 清水伸一, 鬼丸力也, 木下留美子, Gerard Bengua, 宮本直樹, 鈴木隆介, 白土博樹
第101回日本医学物理学会, 09 May 2011
Web - 対向型PET装置を用いた3次元分子追跡装置の基礎検討
右近直之, 石川正純, 棚邊哲史, 山口哲, 宮本直樹, Gerard Bengua, 志賀哲, 玉木長良, 白土博樹
第101回日本医学物理学会, 09 May 2011
Web - スポット陽子線照射における体内マーカーの問題点〜前立腺位置合わせと飛程変化に関する考察〜
山中琢, 松浦妙子, 石川正純, Kenneth Sutherland, 清水伸一, 鬼丸力也, 木下留美子, Gerard Bengua, 宮本直樹, 鈴木隆介, 白土博樹
第101回日本医学物理学会, 09 May 2011
Web - Real-time tumor-tracking, spot scanning proton beam therapy
Shirato H, Shimizu S, Onimaru R, Kinoshita R, Umegaki K, Matsuura T, Miyamoto N, Ishikawa M, Hiramoto K, Nakamura
PTCOG 50, 08 May 2011, Oral presentation
Philadelphia, [International presentation] - Dose distribution analysis of moving target irradiated by proton spot scanning combined with gating technique
Yusuke Fujii, Toru Umekawa, Rintaro Fujimoto, Yoshihiko Nagamine, Masumi Umezawa, Kazuo Hiramoto, Hiroshi Akiyama, Naoki Miyamoto, Taeko Matsuura, Kikuo Umegaki, Hiroki Shirato
PTCOG 50, 08 May 2011, Poster presentation
Philadelphia, [International presentation] - Improvement of Tracking Accuracy and Stability with Utilizing a Color Image Intensifier in Real-time Tumor-tracking Radiotherapy System
Naoki Miyamoto, Masayori Ishikawa, Kenneth Sutherland, Gerard Bengua, Ryusuke Suzuki, Hiroki Shirato
52nd ASTRO Annual Meeting, 30 Oct. 2010, Poster presentation
San Diego, [International presentation] - Conceptual Design of PET-linac System for Molecular-guided Radiotherapy
Masayori Ishikawa, Kenneth Sutherland, Gerard Bengua, Ryusuke Suzuki, Naoki Miyamoto, Norio Katoh, Shinichi Shimizu, Rikiya Onimaru, Hidefumi Aoyama, Hiroki Shirato
52nd ASTRO Annual Meeting, 30 Oct. 2010, Poster presentation
San Diego, [International presentation] - Feasibility Study on Molecular-imaging Based Tracking System for Lung Cancer Treatment
Satoshi Tanabe, Masayori Ishikawa, Kenneth Sutherland, Gerard Bengua, Ryusuke Suzuki, Naoki Miyamoto, Norio Katoh, Shinichi Shimizu, Rikiya Onimaru, Hidefumi Aoyama, Hiroki Shirato
52nd ASTRO Annual Meeting, 30 Oct. 2010, Poster presentation
San Diego, [International presentation] - 動体追跡放射線治療における画像処理を応用したマーカ追跡精度の向上
宮本直樹, 石川正純, Kenneth Sutherland、Gerard Bengua, 鈴木隆介, 白土博樹
第100 回日本医学物理学会, 17 Sep. 2010
東京 - 動体追跡データに基づく腫瘍および周辺臓器のDVH 線量解析-JCOG0702 プロトコルへの適用-
石川正純, 宮本直樹, Kenneth Sutherland、Gerard Bengua, 鈴木隆介, 白土博樹
第100 回日本医学物理学会, 17 Sep. 2010
東京 - 新規ライナック導入に伴うコミッショニング手順に関する報告
鈴木隆介, 石川正純, 宮本直樹, Gerard Bengua, Kenneth Sutherland, 白土博樹
第99 回日本医学物理学会, 09 Apr. 2010
横浜 - 光ファイバ線量計を用いた高エネルギーγ線線量測定におけるチェレンコフ光除去方法の検討
太田真緒, 石川正純, 江口奈弥帆, Gerard Bengua, 鈴木隆介, 宮本直樹, Kenneth Sutherland, 白土博樹
第99 回日本医学物理学会, 09 Apr. 2010
横浜 - Basics of real-time tumor tracking radiothrepy (RTRT) and development of a next generation RTRT
Naoki Miyamoto, Masayori Ishikawa, Kenneth Sutherland, Bengua Gerard, Ryusuke Suzuki, Shinichi Shimizu, Rikiya Onimaru, Hidefumi Aoyama, Hiroki Shirato
5th International Symposium on Medical, Bio- and Nano-Electronics, 24 Feb. 2010, English, Invited oral presentation
Sendai, [Invited], [International presentation] - Can the real-time tumor-tracking radiotherapy give the planned dose to the tumor? DVH analysis based on measured real-time tracking data
Masayori Ishikawa, Kenneth Sutherland, Gerard Bengua, Ryusuke Suzuki, Naoki Miyamoto, Norio Katoh, Shinichi Shimizu, Rikiya Onimaru, Hidefumi Aoyama, Hiroki Shirato
51st ASTRO Annual Meeting, 30 Oct. 2009, Poster presentation
Chicago, [International presentation] - 動体追跡装置を用いた肺定位照射時の投与線量解析―動体追跡データに基づくDVH解析―
石川正純, Kenneth Sutherland, 宮本直樹, Gerard Bengua, 清水伸一, 青山英史, 鬼丸力也, 木村傑, 白土博樹
日本放射線腫瘍学会第22回学術大会, 17 Sep. 2009 - 動体追跡放射線治療におけるＸ線透視条件の最適化
宮本直樹, 石川正純, Kenneth Sutherland、Gerard Bengua, 清水伸一, 青山英史, 鬼丸力也, 木村傑, 白土博樹
第98 回日本医学物理学会, 17 Sep. 2009 - 動体追跡装置におけるコントラスト-ノイズ比（ＣＮＲ）の測定方法の検討
木村傑, 宮本直樹, 石川正純, Kenneth Sutherland、Gerard Bengua, 清水伸一, 青山英史, 鬼丸力也, 白土博樹
第98 回日本医学物理学会, 17 Sep. 2009 - 体内臓器同期照射を目的とした次世代動体追跡装置の開発〜複数マーカ追跡への挑戦〜
石川正純, Kenneth Sutherland, 宮本直樹, Gerard Bengua, 清水伸一, 青山英史, 鬼丸力也, 木村傑, 白土博樹
第97回日本医学物理学会学術大会, 17 Apr. 2009
横浜 - 体内臓器同期照射を目的とした次世代動体追跡装置の開発〜透視画像の歪みと位置計算誤差〜
宮本直樹, 石川正純, Kenneth Sutherland、Gerard Bengua, 清水伸一, 青山英史, 鬼丸力也, 木村傑, 白土博樹
第97回日本医学物理学会学術大会, 17 Apr. 2009
横浜 - 体内臓器同期照射を目的とした次世代動体追跡装置の開発〜デジタル画像機器としての定量的評価〜
木村傑, 石川正純, Kenneth Sutherland, 宮本直樹, Gerard Bengua, 鈴木隆介, 清水伸一, 青山英史, 鬼丸力也, 白土博樹
第97回日本医学物理学会学術大会, 17 Apr. 2009
横浜 - 対向型PET装置を用いた患者位置確認システムの開発−GEANT4基礎シミュレーション−
山口哲, 石川正純, 棚邊哲史, Gerard Bengua, Kenneth Sutherland, 宮本直樹, 鈴木隆介, 青山英史, 武島嗣英, 白土 博樹
第97回日本医学物理学会学術大会, 17 Apr. 2009
横浜 - 対向型PET装置を用いた分子イメージング動体追跡装置の開発〜18F点線源を用いた追跡精度の検証〜
棚邊哲史, 石川正純, 山口哲, 武島嗣英, 鈴木隆介, 宮本直樹, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹
第97回日本医学物理学会学術大会, 17 Apr. 2009
横浜 - 次世代動体追跡装置の開発〜位置計算誤差の評価〜
宮本直樹, 石川正純, Gerard Bengua, 鈴木隆介, 木村傑, Kenneth Sutherland, 清水伸一, 青山英史, 鬼丸力也, 白土博樹
第19回日本高精度放射線外部照射研究会, 31 Jan. 2009
名古屋 - 小型加速器中性子源を用いた中性子共鳴吸収断層撮像
加美山隆, 宮本直樹, 富岡智, 小崎完
日本原子力学会秋の大会, 2008
高知 - Epithermal neutron tomography with time-of-flight technique
Takashi Kamiyama, Hirotaka Sato, Naoki Miyamoto, Hirokatsu Iwasa, Yoshiaki Kiyanagi, Susumu Ikeda
IEEE Nuclear Science Symposium and Medical Imaging Conference, 28 Oct. 2007, Oral presentation
Honolulu, [International presentation] - 中性子共鳴吸収分光法と計算機断層撮像法を利用した核種分布の非破壊分析
宮本直樹, 小崎完, 富岡智, 加美山隆
日本原子力学会秋の大会, 2007
北九州 - 小型加速器を利用した中性子共鳴吸収CTによる核種分布の非破壊分析
宮本直樹, 小崎完, 富岡智, 加美山隆
日本非破壊検査協会秋季大会,, 2007
札幌 - Study of Neutron Tomography using Neutron Resonance Absorption
Takashi Kamiyama, Hirotaka Sato, Naoki Miyamoto, Hirokatsu Iwasa, Yoshiaki Kiyanagi, Susumu Ikeda
The 18th Meeting of the International Collaboration on Advanced Neutron Sources, 2007, Oral presentation
Beijing, [International presentation] - 光変調材料を用いた赤外線ホログラフィー
宮本直樹, 西山修輔, 富岡智, 榎戸武揚
第6 回核融合エネルギー連合講演会, 2006
富山 - 中赤外光計測を目的とした熱吸収型可視位相変調素子の空間分解能
富岡智, 宮本直樹, 西山修輔, 榎戸武揚
第6 回核融合エネルギー連合講演会, 2006
富山 - ニトロアニソールを用いた赤外線ホログラフィによる画像再生と計測への応用
宮本直樹, 西山修輔, 富岡智, 榎戸武揚
高速度撮影とフォトニクスに関する総合シンポジウム, 2005
市ヶ谷 - Infrared phase-shifting interferometer using the nitroanisole as a two-dimensional detector
Naoki Miyamoto, Shusuke Nisiyama, Satoshi Tomioka, Takeaki Enoto
SPIE International Symposium on Optomechatronic Technologies, Optomechatronic Sensors and Instrumentation, 2005, Poster presentation
Sapporo, [International presentation] - ニトロアニソールを用いた赤外位相情報の可視化
宮本直樹, 西山修輔, 富岡智, 榎戸武揚
第65 回応用物理学会学術講演会, 2004
仙台
Courses
- 医用放射線計測学（2017）
北海道大学大学院医理工学院 - Medical Physics School（2017）
北海道大学大学院医理工学院 - 基礎放射線治療物理学（2017）
北海道大学大学院医理工学院 - 総合医理工学研究Ⅰ（2017）
北海道大学大学院医理工学院 - 総合医理工学研究II（2017）
北海道大学大学院医理工学院 - 医学総論 放射線医学（2017）
北海道大学大学院医学研究科 - 医学総論 がん放射線治療実習III（高精度放射線治療）（2017）
北海道大学大学院医学研究科 - 臨床医学物理学実習（治療計画）（2017）
北海道大学大学院医学研究科 - 臨床医学物理学実習（品質管理）（2017）
北海道大学大学院医学研究科 - 臨床医学物理学実習（品質管理）（2017）
北海道大学大学院医理工学院 - 臨床医学物理学実習（陽子線・画像誘導）（2017）
北海道大学大学院医理工学院 - 先端医理工学研究Ⅰ（2017）
北海道大学大学院医理工学院 - 先端医理工学研究II（2017）
北海道大学大学院医理工学院 - 医学総論 医学物理工学（2016）
北海道大学大学院医学研究科 - 医学総論 がん放射線治療実習Ⅲ（高精度放射線治療）（2016）
北海道大学大学院医学研究科 - 放射線治療物理学実習Ⅰ（2016）
北海道大学大学院医学研究科 - 放射線治療物理学実習II（2016）
北海道大学大学院医学研究科 - 放射線治療物理学実習III（2016）
北海道大学大学院医学研究科
Affiliated academic society
Research Themes
- MR画像誘導陽子線治療システムおよび磁場下の治療計画・検証技法に関する基盤開発
科学研究費助成事業
01 Apr. 2024 - 31 Mar. 2028
松浦 妙子, 宮本 直樹, 打浪 雄介, 高尾 聖心, 陳 叶, 橋本 孝之, 栗山 靖敏, 加藤 徳雄
日本学術振興会, 基盤研究(B), 北海道大学, 24K02389 - 肺癌に対する陽子線治療の選択基準確立に向けた心肺相互作用勘案NTCPモデル構築
科学研究費助成事業
01 Apr. 2022 - 31 Mar. 2025
青山 英史, 鈴木 隆介, 宮本 直樹, 高尾 聖心, 金平 孝博, 橋本 孝之, 小橋 啓司, 西岡 健太郎, 田口 大志
昨年度は、集積した症例のDICOM-RTにおける心臓・肺などの関心領域（ROI）設定が完了し、Dose Volume Histogram（DVH）解析を実施し、以下の探索的研究を行った。
局所進行肺癌化学療法後に補助療法として投与される免疫チェックポイント阻害剤休薬の一因である放射線性肺臓炎に着目し、心臓並びに肺の相互作用を勘案したNormal Tissue Complication Probability（NTCP）モデルを作成すべく、各種臨床指標並びにDVH指標を統計学的に検討した。Grade2以上の肺臓炎の予測因子として、単変量解析では肺並びに心臓のDVH指標、年齢等の複数の臨床指標が有意な因子として抽出されたが、多変量解析において心臓指標は有意とならず、肺臓炎のNTCPモデルに心臓指標を組み込むことは困難であると考えられた。また、心毒性に関しても同様の検討を行う予定であったが、心関連事象発生数が少なく、モデル作成は困難と判断した。
次に全生存率に着目し、各種臨床指標とDVH指標との関連を統計解析したところ、単変量、多変量解析において肺、心臓のDVH指標が有意な因子として抽出され、また、臨床指標として年齢、Performance status、Nodal stage、喫煙の有無、化学療法併用の有無、原発巣の体積も有意な因子であった。心臓指標が独立した予後因子の一つであることに着目し、その予測モデルを検討したところ、原発巣の体積並びに局在の2変量によるモデルが良い予測能を有していた。
今年度は、肺・心臓の両指標を内包する全生存率に関する上記モデルを基に放射線毒性高リスク群を抽出し、3次元原体照射、強度変調放射線照射、陽子線照射の各照射モダリティの適切な選択に資する検討を行う予定である。
日本学術振興会, 基盤研究(B), 北海道大学, 23K24269 - 肺癌に対する陽子線治療の選択基準確立に向けた心肺相互作用勘案NTCPモデル構築
科学研究費助成事業 基盤研究(B)
01 Apr. 2022 - 31 Mar. 2025
青山 英史, 鈴木 隆介, 宮本 直樹, 高尾 聖心, 金平 孝博, 橋本 孝之, 小橋 啓司, 西岡 健太郎, 田口 大志
日本学術振興会, 基盤研究(B), 北海道大学, 22H03008 - Three-dimensional density distribution mesurement of spieces of mixtured gas by shearing interferometry with multi-wavelength light
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
01 Apr. 2022 - 31 Mar. 2025
富岡 智, 山内 有二, 宮本 直樹, 松本 裕
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 22K04117 - MR画像誘導と併用可能なリアルタイム陽子線飛程検出法の開発
科学研究費助成事業
01 Apr. 2021 - 31 Mar. 2025
松浦 妙子, 宮本 直樹, 高尾 聖心, 栗山 靖敏
令和5年度は、MR画像誘導陽子線治療装置の照射ノズル構造の検討および治療計画における陽子線軌道湾曲を含めた飛程不確かさマージンのモデル化についての検討を進め，前者については論文投稿を行い，後者については学会発表を行った．装置構成の更なる改善やマージンモデルを不均質体系に一般化するアルゴリズムの開発は後続の科研費研究にて実施する予定で初期検討を開始した．
加えて，令和5年度は，MR磁場下の陽子線照射と音響波伝搬シミュレーションを統合したシミュレーションシステムの構築を完了させた．水中のビーム照射においては，磁場下で陽子線軌道が湾曲することでγ波波形に強度や波形到達時刻の変化が見られた．今後よりシステマティックに種々の臨床条件で検討を進めて論文化する予定である．
また，MR画像誘導陽子線治療に用いる超音波検出器の体表設置を想定し，実験データ解析をもとに，プローブヘッド形状やサイズの検討を行った．臨床線量で音響波観測が可能なのは，十分な音圧を担保できるビーム軸近傍の領域と考えられるが，この領域では3 cm程度の小型プローブヘッドで十分飛程計測が可能であった．一方で，現在のセンサには窓枠部分にステンレスが用いられており，MRI装置と同時に使うには適さないことが分かった．メーカーと議論し，今後チタンやセラミクスなどの素材を検討していく予定である．プローブヘッドの基材として用いているゲルについても，飛程位置を決める第一因子であるγ波ピークは計測可能であるものの，耐久性の観点やピーク以降の波形再現性について現状課題が残るため，別素材を含めた検討を開始した．
日本学術振興会, 基盤研究(B), 北海道大学, 23K21418 - MR画像誘導と併用可能なリアルタイム陽子線飛程検出法の開発
科学研究費助成事業 基盤研究(B)
01 Apr. 2021 - 31 Mar. 2025
松浦 妙子, 宮本 直樹, 高尾 聖心, 栗山 靖敏
日本学術振興会, 基盤研究(B), 北海道大学, 21H02859 - Research and development about helium and proton hybrid system with proton CT and Immuno-radiotherapy
Grants-in-Aid for Scientific Research
01 Apr. 2019 - 31 Mar. 2024
白土 博樹, 宮本 直樹, 平田 雄一, 田中 創大, 高尾 聖心, 梅垣 菊男, 茶本 健司, 清水 伸一, Nam JinMin, 小野寺 康仁, 松浦 妙子
① 2019年度に決定した、短時間（0.1秒以下）でエネルギー変更可能な小型加速器の基本設計に基づき、小型加速器の要素技術の設計を行い、短時間（0.1秒以下）でエネルギー変更を可能とする回転ガントリーを含む照射・輸送系の磁場制御設計を行った。
② 陽子からヘリウムに短時間で加速粒子を変更できる混合加速方式を検討、2023年度に制作開始するべく、陽子線CTの機器としての仕様を検討した。
③ 陽子線CT値-ヘリウムSPR変換プロセスと、X線CT値利用時の精度を比較し、高エネルギー陽子線CTに必要な要素機器と制御方式の仕様を明確化した。
④ 高エネルギー陽子線ビームを照射する場合に、ビームの人体への入射方向を意図的に偏心させ、ノズルの外側から照射野中心に向かったビームアングルとするための加速器・照射系の検討を行った。
⑤ PD-1阻害剤およびPD-L1阻害剤を用いて、がん細胞の制御に最適なLET、ROSとミトコンドリアの分布を計測し、放射線と阻害剤の組み合わせによる相関を検討した。T細胞のPD-1阻害に関する条件検討を行っていたところ、当初の想定に反し、がん細胞での観察と類似の条件ではT細胞の観察が困難であることが判明した。T細胞を観察した上で条件決定することが不可欠であるため、T細胞のPD-1阻害に関する条件決定のための追加検討事項として、培養条件や使用する蛍光色素の種類を複数追加し、T細胞を観察するための至適条件の検討を行った。
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 19H03591 - Marker-less volume imaging technique for real-time tumor tracking radiation therapy
Grants-in-Aid for Scientific Research
01 Apr. 2020 - 31 Mar. 2023
宮本 直樹
本研究では、放射線治療中に得られる2方向X線透視画像を利用し、体内マーカを利用することなく（マーカーレス）、リアルタイムに体内の3次元構造を取得するボリュームイメージング技術を開発することを目的とする。この提案技術の実現により、体内にマーカーを留置するという侵襲性のあるプロセスを無くすことができ、加えて、ボリュームイメージを得ることによる高精度な呼吸性移動対策をFLASH などの超高線量率照射を含むあらゆる照射において実施可能となる。本研究では、研究期間内に各要素技術の開発を進め、十分な質と量のデータにより精度検証を実施し、ボリュームイメージングを利用した治療ビーム照射制御の臨床的有用性を明らかにする。
2021年度は、昨年度のデジタルファントムによる画像合成精度評価に続き、実際の患者の4DCTデータによる評価を進めた。同一患者で異なる日に撮影された4DCTデータを利用し、1つの4DCTデータを変形モデリング用、残りの4DCTデータを検証に用い、モデリングの課程で得られた固有体内変形ベクトルの線形結合にもとづくボリュームイメージングにより、検証データをどこまで再現できるか評価した。合成画像の画素値と構造の再現性を評価した結果、先行研究（主にデジタルファントムでの評価）と同等の性能が得られた。したがって、放射線治療中に正確な固有値を評価することにより、標的の位置や体内構造の評価に応用できるボリュームイメージをリアルタイムで合成できると考えられ、提案手法の臨床的な実行可能性を示すことができた。
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 20H03612 - Real-time volumetric image generation based on CT deformation driven by simultaneous monitoring of internal landmarks and object surface
Grants-in-Aid for Scientific Research Challenging Research (Exploratory)
29 Jun. 2018 - 31 Mar. 2021
Miyamoto Naoki
We developed a method to reconstruct 3D in vivo information in real time by using the positional information of biological surfaces and in vivo markers through modeling of in vivo deformations using pre-learning data. Using a patient's 4DCT acquired for radiotherapy, we evaluated the image synthesis accuracy of the in vivo reconstruction method developed in this project as the normalized root mean square error (NRMSE) between the ground truth image and the synthesized image. The image synthesis accuracies for the training data and the validation with motion beyond the training data were about 7% and 11%, respectively. In addition, the accuracy of tumor location evaluation was less than 1 mm. These results suggest that the accuracy is sufficient for application in radiotherapy.
Japan Society for the Promotion of Science, Challenging Research (Exploratory), Hokkaido University, 18K19887 - Development of minimum invasive real-time markerless image guided radiotherapy technique using minimum space information.
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
01 Apr. 2018 - 31 Mar. 2021
Shimizu Shinichi
In the real-time tumor tracking radiotherapy, feature point information, that is used for gating, is obtained by fluoroscopic X-ray images. There still problems exist:1.X-ray exposure from diagnostic X ray that used for gating 2.insertion of a gold marker etc. as a feature pointReduce or eliminate X-ray exposure by making the observing area through diagnostic X-rays as small as possible to acquire target movement information or establishing the method of processing gating information obtained using MRI technology without using fluoroscopy were considered to be the goal of this study.
X-rays are still optimal for acquiring organ motion information within human body necessary for gating treatment in real time, but a method for limiting the range was achieved in this study. In addition, we succeeded in trying to visualize the position of organs with MRI image data without using X-rays when preparing for treatment, and there were expectations for the promotion of future research.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 18H02758 - Three-dimensional refractive index measurement system using shear interferometer
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
01 Apr. 2018 - 31 Mar. 2021
Tomioka Satoshi
In order to measure the three-dimensional refractive index distribution, a coupling method of interferometer and computed tomography can be used. As the interferometer to measure delay of wavefront due to object from different incident angles, we adopted a shearing interferometer, which always satisfies interference condition during changing incident angle since the shearing interferometer does not use a reference wave. We demonstrated that interferograms obtained with the shearing interferometer are not affected by vibration caused by changing of the incident direction. In addition, we measured the three-dimensional distribution of the refractive index of the gas near the candle flame, and the reconstructed result was qualitative agreed.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 18K04158 - Real-time tumor-tracking arc therapy for stereotactic body radiotherapy
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
01 Apr. 2017 - 31 Mar. 2020
Miyamoto Naoki
In this study, we have developed the fundamental techniques to realize real-time tumor-tracking arc radiation therapy for stereotactic body radiation therapy. In order to show the clinical feasibility and effectiveness, expected treatment time and dosiemtric characteristics were evaluated. Treatment time could be reduced by the proposed treatment technique compared with the current treatment system used for real-time tumor-tracking. For the dosimetric validation, film and ion-chamber measurement with dynamic phantom was conducted. It was confirmed that the acceptable dosimetric characteristics could be achievable with the proposed technique. Dosimetric error between the measured dose and the planned dose was within 3% in ion-chamber measurement. It was suggested that the proposed method has clinical feasibility.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 17H04115 - Development of robust proton beam scanning treatment technology considering target heterogeneity and movement
Grants-in-Aid for Scientific Research
01 Apr. 2016 - 31 Mar. 2020
Umegaki Kikuo
We have proposed a new approach of treatment plan optimization method considering the probability distribution of dose error caused by the various uncertainties in proton beam therapy. The three-dimensional dose distribution is optimized to irradiate the target tumor while sparing the normal tissue by controlling the dose for each spot with intensity modulation. We have evaluated probabilistic dose errors caused by variation of individual device performance, patient positioning error, target tumor movement under respiration, etc.. The dose error considering the anisotropy unique to the proton beam is also clarified. Beyond the conventional treatment plan concept of contouring the tumor shape and providing a uniform margin, we have constructed a robust optimization method considering the probability distribution of dose error. The method was evaluated and demonstrated using the actual proton beam therapy system.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 16H05235 - Development of therapeutic response-guided radiotherapy based on dose evaluation using CBCT images
Grants-in-Aid for Scientific Research
01 Apr. 2016 - 31 Mar. 2020
Takao Seishin
In this study, we have developed the therapeutic response-guided radiotherapy technique based on the quantitative estimation of changes of therapeutic response using cone-beam CT (CBCT) images. We improved the image quality of CBCT images, calculated the water equivalent thickness in spot scanning proton beam thereapy, and established a method to estimate the treatment response from changes in the water equivalent thickness.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 16K10381 - Attempt of 4D-IGRT by Volume Matching Method of 4D-CBCT and Therapy Planning CT
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
01 Apr. 2015 - 31 Mar. 2018
Shimizu Shinichi
We conduct research using 2 axis of diagnostic X-ray fluoroscope that consist real-time tumour-tracking (RTRT) system installed in a proton beam treatment gantry. With the use of the system, we conduct a research aimed constructing a 4D-IGRT radiotherapy system that can treat cancer in consideration of spatial and temporal fluctuations and also respiratory movement of tumors. Four-dimensional cone beam CT (4D-CBCT) image is obtained from the fluoroscopic image of the RTRT system. From the 4D-CBCT image group composed of a plurality of respiratory phases, a CT image that represent the same respiratory phase as the CT image used for the treatment plan is selected. We develop an advanced real time image guidance system aiming marker-less 4D-RT using selected CBCT image and its source image.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 15H04899 - Weighted reconstruction algorithm for time varying object with incomplete projection data
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
01 Apr. 2015 - 31 Mar. 2018
Tomioka Satoshi
In order to monitor positions and shapes of tissue inside body during radiotherapy, we propose a computed tomographic reconstruction technique with limited projection beams. In this technique, the number of angles of projection beams measured at the time of reconstruction is small and most projection beams are lacked. The lacked projection data are replaced by the projection data measured in the past. Since the past state of body is different from that at the reconstructing time, the contribution of each projection data to the reconstructed image should be modified. By applying the weighted reconstruction algorithm to take into account the contribution of the projection data which includes past projection data, we demonstrated feasibility of low exposure monitoring.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 15K06097 - Development of respiratory phase segmentation algorithm based on the analysis of internal target motion for high accurate respiratory-gated radiation therapy
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
01 Apr. 2014 - 31 Mar. 2017
Miyamoto Naoki
Respiratory-gated irradiation is realized by monitoring three-dimensional location of internal fiducial marker in real-time tumor-tracking radiation therapy. Irradiation accuracy could be improved by monitoring respiratory phase in addition to the marker location. In this research, the novel algorithm of respiratory phase segmentation based on the analysis of three-dimensional trajectory data of the fiducial marker. Irradiation efficiency was evaluated from the log data retrospectively assuming that patient setup was conducted by proposed method. About 20 % of irradiation efficiency was obtained by proposed method even in the small gating windows size, +/- 1 mm. The evaluated efficiency was less than 10 % in conventional setup procedure. Hence, it is expected that the irradiation accuracy can be improved while keeping the acceptable irradiation efficiency.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 26460714 - Functional evaluation in animal models of radiosurgical brain lesions
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
01 Apr. 2014 - 31 Mar. 2017
Tanaka Masaki, KUNIMATU JUN, TAKEYA RYUJI, ISHIKAWA MASAYORI, MIYAMOTO NAOKI
Experimental technique to produce focal brain lesions may provide opportunities for future research exploring mechanisms of brain function and recovery from injury. As a candidate method, we evaluated the radiosurgical technique. We also tried to develop behavioral and electrophysiological techniques to examine subcortical brain functions, and explored new methods to generate focal brain lesions. We evaluated the oculomotor behavior in monkeys up to 8 months following irradiation to the frontal eye field. In addition, we have developed several behavioral tasks and a method to record cortical potentials through epi-dural electrodes, both of which are usable to detect subcortical dysfunction. Further, we performed a feasible study of chemogenetic application to monkeys by injecting a viral vector into the cerebellum. Through these studies, we could obtain valuable information for future studies.
Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 26560454 - Approaches to the 4D-CBCT using 2 axis fluoroscopic X-ray
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
01 Apr. 2012 - 31 Mar. 2015
SHIMIZU Shinichi, MIYAMOTO Naoki, TAKAO Seishin
Construction of a radiation therapy system which can consider respiratory movement of tumor and organs. Location variation and irradiation time are also considered using the 2 axis of X-ray fluoroscopic motion tracking device that are installed at the proton therapy within the gantry. To enable image of the cone-beam CT to get the original source image of 4-dimensional CBCT (4D-CBCT) with the use of the motion tracking device and try to develop the principle and performs imaging test by phantom. Morphological changes of the patients on the treatment couch by imaging moving tumors and organs by 4D-CBCT, the appropriateness of the treatment planning time and compare present status of tumor irradiated and the condition of the normal tissues are to be verified.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 24591829 - Development of a research technique to create animal model of brain lesions using therapeutic linear accelerator
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
01 Apr. 2012 - 31 Mar. 2014
TANAKA Masaki, ISHIKAWA Masayori, KUNIMATU Jun, MIYAMOTO Naoki
We developed a research technique to create animal model of brain lesions using the therapeutic linear accelerator. A total of four irradiations (130-150 Gy) were performed on the right frontal eye field of three Japanese monkeys. During a few weeks following irradiation, brain edema was evident in MRI and the performance of oculomotor tasks was declined; however, it recovered thereafter. For one monkey that was followed up about 8 months, the behavioral deficits reappeared in the 4th month and gradually progressed. Postmortem histological examination in two animals revealed large necrosis in the white matter and surrounding hemorrhage, but the cortical gray matter retained layers. This technique can be applied to deep brain structures in the future study. We now plan to use lower doses and will follow up longer interval.
Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 24650206 - Real-time tumor-tracking radiotherapy system with monoscocpic imaging system
Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
01 Apr. 2012 - 31 Mar. 2014
MIYAMOTO Naoki
In this study, the novel monoscopic imaging system that can be utilized for gated-radiotherapy is proposed. The proposed system can reduce imaging dose due to pulsed fluoroscopy during treatment and can realize compact system. It was shown that the measurement error of the proposed technique was within acceptable level in most cases by performing the evaluations with actual marker positions and actual marker trajectories. In addition, the measurement error can be minimized by optimizing imaging geometry. As a result, the feasibility for clinical use was shown.
Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, 24791258 - ２軸Ｘ線を用いた４Ｄ−ＣＢＣＴの撮像方法構築による相互作用放射線治療の試み
科学研究費補助金(基盤研究(C))
Apr. 2012 - Mar. 2014
清水 伸一
平成24年度は、2軸X線を用いた4次元コーンビームCT(4D-CBCT)撮像方法構築のため、北海道大学にて保有する動体追跡装置を用いて放射線治療を行ったデータのログを用いて、4D-CBCT の元画像 を撮像する際のガントリー回転速度と画像取得位置、取得可能な画像データ数、4D-CBCT 画像を作成する際に得 られる呼吸位相数のシミュレーションを行った。その結果を基に、2軸X線撮像系を実際に用いてファントム実験およびCBCT画像を計算・取得するための元画像の撮像を行った。これら元画像は、次年度以降の研究で予定している4D-CBCT画像取得のためのシミュレーション、ファントムの考案、作成および演算法最適化に用いる予定である。本研究の実行可能性について事前検討のために作成し、計算を行った基本的なシミュレーションソフトウエアの結果を基に、CBCT撮像のソフトウエアの本作成に着手した。このソフトウエアの本作成ならびに動体追跡放射線治療で取得された実際の治療ログを用いることにより、陽子線治療装置ガントリー上で取得可能な4D-CBCT 元画像の必要撮影条件の検討を行った。知的財産申請の都合上本研究に直接関与する学会・論文発表は行えなかったが、関連する基礎研究成果として骨盤部CBCT画像での臓器輪郭描出に関する検討．としてコーンビームCTに関係する研究内容を日本医学放射線学会北日本地方会にて学会発表を行った。
文部科学省, Competitive research funding - Development of 4-dimensional Cone Beam CT for precise IGRT
Research Grant for Nuclear Technology in Medicine
Apr. 2011 - Mar. 2012
Naoki Miyamoto
Association for Nuclear Technology in Medicine, Principal investigator, Competitive research funding - Development of real-time tumor-tracking radiotherapy system with utilizing color X-ray image intensifier
Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
2010 - 2011
MIYAMOTO Naoki
The image processing that is combination of edge enhancement and subtraction was useful to extract the marker in the fluoroscopic image. This image processing can reduce the probability of marker lost and misidentification. And also, the imaging dose could be reduced while maintaining the equivalent image quality by applying the motion adaptive recursive image filter.
Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, 22791163 - Pattern projection system for patient setup in radiation therapy
Research Grant for Young Scientists
Apr. 2009 - Mar. 2010
Naoki Miyamoto
Hokkaido University, Principal investigator, Competitive research funding
Industrial Property Rights
- 治療計画装置、治療計画生成方法及びコンピュータプログラム
Patent right, 高柳 泰介, 山田 貴啓, 藤井 祐介, 梅川 徹, 白土 博樹, 清水 伸一, 松浦 妙子, 宮本 直樹, 高尾 聖心, 平田 雄一, 田中 創大, 株式会社日立製作所, 国立大学法人北海道大学
特願2021-057201, 30 Mar. 2021
特開2022-154269, 13 Oct. 2022
特許第7489667号, 16 May 2024
202403013940696965 - 放射線治療システム、動き追跡装置、および動き追跡方法
Patent right, 張 凌峰, 藤井 孝明, 藤高 伸一郎, 宮本 直樹, 梅垣 菊男, 宮崎 康一, 株式会社日立製作所, 国立大学法人北海道大学
特願2022-137185, 30 Aug. 2022
特開2024-033548, 13 Mar. 2024
202403002212284136 - 放射線治療装置
Patent right, 宮本 直樹, 梅垣 菊男, 清水 伸一, 富岡 智, ▲高▼尾 聖心, 国立大学法人北海道大学
JP2019020395, 23 May 2019
特許第7362130号, 06 Oct. 2023
202303003901144626 - 動体追跡装置とそれを備えた放射線治療システム、プログラム、および動体の追跡方法
Patent right, 梅川 徹, 宮崎 康一, 藤井 孝, 清水 伸一, ▲高▼尾 聖心, 梅垣 菊男, 宮本 直樹, 加藤 徳雄, 株式会社日立製作所, 国立大学法人北海道大学
特願2019-056069, 25 Mar. 2019
特開2020-156562, 01 Oct. 2020
特許第7311859号, 11 Jul. 2023
202303011823701516 - 放射線治療システム
Patent right, 山田 貴啓, 藤井 祐介, 藤本 林太郎, 宮崎 康一, 松浦 妙子, 宮本 直樹, 株式会社日立製作所, 国立大学法人北海道大学
特願2021-145846, 08 Sep. 2021
特開2023-038962, 20 Mar. 2023
202303020758720108 - 動体追跡装置、放射線照射システム及び動体追跡方法
Patent right, 山田 貴啓, 藤井 祐介, 宮本 直樹, 清水 伸一, ▲高▼尾 聖心, 宮崎 康一, 株式会社日立製作所, 国立大学法人北海道大学
特願2021-111908, 06 Jul. 2021
特開2023-008382, 19 Jan. 2023
202303006796752290 - 治療計画装置、治療計画生成方法及びコンピュータプログラム
Patent right, 高柳 泰介, 山田 貴啓, 藤井 祐介, 梅川 徹, 白土 博樹, 清水 伸一, 松浦 妙子, 宮本 直樹, 高尾 聖心, 平田 雄一, 田中 創大, 株式会社日立製作所, 国立大学法人北海道大学
特願2021-057201, 30 Mar. 2021
特開2022-154269, 13 Oct. 2022
202203003533802874 - 放射線治療装置
Patent right, 藤井 孝明, ▲高▼尾 聖心, 宮本 直樹, 松浦 妙子, 梅垣 菊男, 国立大学法人北海道大学
JP2018009499, 12 Mar. 2018
特許第7122003号, 10 Aug. 2022
202203013414957822 - 精度検証装置、放射線治療システム、精度検証方法及びコンピュータプログラム
Patent right, 宮崎 康一, 梅垣 菊男, 宮本 直樹, 梅川 徹, 藤井 孝明, 株式会社日立製作所, 国立大学法人北海道大学
特願2020-058288, 27 Mar. 2020
特開2021-153952, 07 Oct. 2021
202103018501067536 - 動体追跡装置とそれを備えた放射線治療システム、プログラム、および動体の追跡方法
Patent right, 梅川 徹, 宮崎 康一, 藤井 孝, 清水 伸一, ▲高▼尾 聖心, 梅垣 菊男, 宮本 直樹, 加藤 徳雄, 株式会社日立製作所, 国立大学法人北海道大学
特願2019-056069, 25 Mar. 2019
特開2020-156562, 01 Oct. 2020
202003018251233772 - 動体追跡装置および放射線照射システム
Patent right, 山田 貴啓, 梅川 徹, 藤井 祐介, 宮本 直樹, 梅垣 菊男, 株式会社日立製作所, 国立大学法人北海道大学
特願2016-088163, 26 Apr. 2016
特開2017-196036, 02 Nov. 2017
特許第6744123号, 03 Aug. 2020
202003006278320407 - 放射線照射システムおよび動体追跡装置
Patent right, 藤井 祐介, 宮本 直樹, 梅垣 菊男, 清水 伸一, 梅川 徹, 山田 貴啓, 株式会社日立製作所, 国立大学法人北海道大学
特願2016-103596, 24 May 2016
特開2017-209243, 30 Nov. 2017
特許第6742153号, 30 Jul. 2020
202003013293330709 - 粒子線治療システムおよびリッジフィルタならびにリッジフィルタの製造方法
Patent right, 高柳 泰介, 藤高 伸一郎, 中島 千博, 村田 朋貴, 松浦 妙子, 宮本 直樹, 梅垣 菊男, 平田 雄一, 株式会社日立製作所, 国立大学法人北海道大学
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特開2017-148204, 31 Aug. 2017
特許第6660761号, 13 Feb. 2020
202003019884618483 - 放射線治療装置および放射線治療方法
Patent right, 宮本 直樹, 梅垣 菊男, 清水 伸一, 富岡 智, ▲高▼尾 聖心, 国立大学法人北海道大学
JP2019020395, 23 May 2019
WO2020-012785, 16 Jan. 2020
202103013693852825 - 放射線治療装置及びベッド位置決め装置並びにベッドの位置決め方法
Patent right, 藤井 祐介, 梅澤 真澄, 藤本 林太郎, 梅川 徹, 白土 博樹, 梅垣 菊男, 宮本 直樹, 小川 和彦, 八木 雅史, 株式会社日立製作所, 国立大学法人北海道大学
特願2018-056379, 23 Mar. 2018
特開2019-166098, 03 Oct. 2019
201903008663920212 - 放射線治療装置及びベッド位置決め装置並びにベッドの位置決め方法
Patent right, 藤井 祐介, 梅澤 真澄, 藤本 林太郎, 梅川 徹, 白土 博樹, 梅垣 菊男, 宮本 直樹, 小川 和彦, 八木 雅史, 株式会社日立製作所, 国立大学法人北海道大学
特願2018-056379, 23 Mar. 2018
特開2019-166098, 03 Oct. 2019
特許第7082366号, 31 May 2022
201903008663920212 - 粒子線照射システムおよび照射計画装置
Patent right, 梅垣 菊男, 藤井 祐介, 藤本 林太郎, 宮本 直樹, 平山 嵩祐, 清水 伸一, 株式会社日立製作所, 国立大学法人北海道大学
特願2018-028532, 21 Feb. 2018
特開2019-141331, 29 Aug. 2019
201903015271582200 - 追跡対象認識シミュレータ、若しくはマーカ認識シミュレータおよび動体追跡装置ならびに放射線照射システム
Patent right, 平山 嵩祐, 梅川 徹, 梅垣 菊男, 宮本 直樹, 山田 貴啓, 藤井 祐介, 株式会社日立製作所, 国立大学法人北海道大学
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201903006104814604 - 放射線治療システム
Patent right, 宮崎 康一, 宮本 直樹, 株式会社日立製作所, 国立大学法人北海道大学
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Patent right, 宮崎 康一, 宮本 直樹, 株式会社日立製作所, 国立大学法人北海道大学
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特許第7057934号, 13 Apr. 2022
201903004960096345 - 放射線治療システム
Patent right, 藤井 孝明, 梅川 徹, えび名 風太郎, 青木 孝道, 梅垣 菊男, 宮本 直樹, 平田 雄一, 山田 貴啓, 株式会社日立製作所, 国立大学法人北海道大学
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特許第6465283号, 18 Jan. 2019
201903017724399935 - 放射線治療装置
Patent right, 藤井 孝明, ▲高▼尾 聖心, 宮本 直樹, 松浦 妙子, 梅垣 菊男, 国立大学法人北海道大学
JP2018009499, 12 Mar. 2018
WO2018-168766, 20 Sep. 2018
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Patent right, 藤井 孝明, ▲高▼尾 聖心, 宮本 直樹, 松浦 妙子, 梅垣 菊男, 国立大学法人北海道大学
JP2018009499, 12 Mar. 2018
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202003014835370660 - 骨セメントを活用した放射線治療用の病変識別マーカーおよび放射線治療用の病変識別マーカーキット
Patent right, 阿保 大介, 作原 祐介, 森田 亮, 宮本 直樹, 国立大学法人北海道大学
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201903007949251419 - 放射線照射システムおよび動体追跡装置
Patent right, 藤井 祐介, 宮本 直樹, 梅垣 菊男, 清水 伸一, 梅川 徹, 山田 貴啓, 株式会社日立製作所, 国立大学法人北海道大学
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201703006208294829 - 動体追跡装置および放射線照射システム
Patent right, 山田 貴啓, 梅川 徹, 藤井 祐介, 宮本 直樹, 梅垣 菊男, 株式会社日立製作所, 国立大学法人北海道大学
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201703002706682504 - 粒子線治療システムおよびリッジフィルタならびにリッジフィルタの製造方法
Patent right, 高柳 泰介, 藤高 伸一郎, 中島 千博, 村田 朋貴, 松浦 妙子, 宮本 直樹, 梅垣 菊男, 平田 雄一, 株式会社日立製作所, 国立大学法人北海道大学
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201703016659902313 - 放射線治療制御装置および放射線治療制御プログラム
Patent right, 宮本 直樹, 清水 伸一, 松浦 妙子, 寅松 千枝, 高▼尾 聖心, 二本木 英明, 平田 雄一, 梅垣 菊男, 国立大学法人北海道大学
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Patent right, 作原 祐介, 高橋 文也, 宮本 直樹, 森田 亮, 国立大学法人北海道大学
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201703016603468793 - 画像処理装置および粒子線治療装置
Patent right, 藤井 孝明, 梅川 徹, 梅垣 菊男, 高尾 聖心, 宮本 直樹, 藤井 祐介, 山田 貴啓, 平田 雄一, 株式会社日立製作所, 国立大学法人北海道大学
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201603007823714870 - 放射線治療システムおよび放射線治療プログラム
Patent right, 宮本 直樹, 清水 伸一, 松浦 妙子, 高▼尾 聖心, 平田 雄一, 梅垣 菊男, 加藤 徳雄, 国立大学法人北海道大学
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201603011303099827 - 放射線治療システム
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特開2013-111406, 10 Jun. 2013
特許第5896211号, 11 Mar. 2016
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特開2015-116284, 25 Jun. 2015
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Patent right, 石川 正純, 宮本 直樹, 篠川 毅, 山中 誓次, 国立大学法人北海道大学, 株式会社島津製作所
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特許第5667489号, 19 Dec. 2014
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Patent right, 石川 正純, 宮本 直樹, 白土 博樹, 篠川 毅, 山中 誓次, 国立大学法人北海道大学, 株式会社島津製作所
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201403059137899701 - 放射線治療用動体追跡装置
Patent right, 石川 正純, 宮本 直樹, 篠川 毅, 山中 誓次, 山崎 純一, 山地 昌行, 山脇 浩一, 国立大学法人北海道大学, 株式会社島津製作所
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特許第5530967号, 25 Apr. 2014
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Patent right, 藤井 祐介, 藤本 林太郎, 梅澤 真澄, 松浦 妙子, 宮本 直樹, 清水 伸一, 寅松 千枝, 高尾 聖心, 二本木 英明, 平田 雄一, 梅垣 菊男, 株式会社日立製作所, 国立大学法人北海道大学
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201403009444680060 - 荷電粒子照射システムおよび照射計画装置
Patent right, 藤井 祐介, 藤本 林太郎, 梅澤 真澄, 松浦 妙子, 宮本 直樹, 清水 伸一, 寅松 千枝, 高▼尾 聖心, 二本木 英明, 平田 雄一, 梅垣 菊男, 株式会社日立製作所, 国立大学法人北海道大学
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Patent right, 宮本 直樹, 清水 伸一, 松浦 妙子, 寅松 千枝, 高▼尾 聖心, 二本木 英明, 平田 雄一, 梅垣 菊男, 国立大学法人北海道大学
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201303090601879821 - 放射線治療用動体追跡装置
Patent right, 石川 正純, 宮本 直樹, 篠川 毅, 山中 誓次, 山崎 純一, 山地 昌行, 山脇 浩一, 国立大学法人北海道大学, 株式会社島津製作所
特願2011-062628, 22 Mar. 2011
特開2012-196325, 18 Oct. 2012
201203034989879378 - 放射線治療用動体追跡装置
Patent right, 石川 正純, 宮本 直樹, 篠川 毅, 山中 誓次, 国立大学法人北海道大学, 株式会社島津製作所
特願2011-062630, 22 Mar. 2011
特開2012-196326, 18 Oct. 2012
201203062435719658 - 放射線治療用動体追跡装置
Patent right, 石川 正純, 宮本 直樹, 白土 博樹, 篠川 毅, 山中 誓次, 国立大学法人北海道大学, 株式会社島津製作所
JP2012001958, 21 Mar. 2012
WO2012-127864, 27 Sep. 2012
201403036897198622 - 放射線治療用動体追跡装置
Patent right, 石川 正純, 宮本 直樹, 篠川 毅, 山中 誓次, 山崎 純一, 山地 昌行, 山脇 浩一, 国立大学法人北海道大学, 株式会社島津製作所
JP2012001959, 21 Mar. 2012
WO2012-127865, 27 Sep. 2012
201403073043761075 - 放射線治療用動体追跡装置
Patent right, 石川 正純, 宮本 直樹, 白土 博樹, 篠川 毅, 山中 誓次, 国立大学法人北海道大学, 株式会社島津製作所
JP2012001958, 21 Mar. 2012
WO2012-127864, 27 Sep. 2012
WO2012-127864, 27 Sep. 2012
201403036897198622 - 放射線治療用動体追跡装置
Patent right, 石川 正純, 宮本 直樹, 篠川 毅, 山中 誓次, 山崎 純一, 山地 昌行, 山脇 浩一, 国立大学法人北海道大学, 株式会社島津製作所
JP2012001959, 21 Mar. 2012
WO2012-127865, 27 Sep. 2012
WO2012-127865, 27 Sep. 2012
201403073043761075
