2023年03月, Wiley, Top downloaded Article　　　　　　　　　　　　　　　
New method of esophageal endoscopic ultrasonography with injected gel: Endoscopic ultrasonography-gel filling method
Shuichi Miyamoto

2022年10月, UEG Week, UEG Week 2022 Travel Grant Award　　　　　　　　　　　　　　　
Shuichi Miyamoto

2016年10月, UEG Week, UEG Week 2016 Basic Science Travel Grant Award　　　　　　　　　　　　　　　
Shuichi Miyamoto

Hepatocellular Carcinoma Rupture after Introducing Lenvatinib: An Autopsy Case Report.
Risako Kohya, Ryo Sugiura, Yoshiya Yamamoto, Hirohito Naruse, Kazuteru Hatanaka, Kenji Kinoshita, Satoshi Abiko, Shuichi Miyamoto, Kazuharu Suzuki, Hanae Kushibiki, Satoru Munakata, Norihiko Shimoyama
Internal medicine (Tokyo, Japan), 62, 7, 995, 998, 2023年04月01日, ［国内誌］
英語, 研究論文（学術雑誌）, Hepatocellular carcinoma (HCC) hemorrhaging/rupture is a rare adverse effect of lenvatinib, and only limited pathological examinations have been reported. This report presents the case of a 69-year-old man who suffered from cardiac arrest and died 7 days after starting lenvatinib treatment for HCC, with an autopsy subsequently performed. Crack and coagulated blood were observed in the largest tumor. Pathologically, the hemorrhaging area was scattered in nearly all of the HCC lesions, regardless of tumor differentiation. This pathological feature is unusual in normal HCC. Thus, it is believed to have been the effect of lenvatinib.

Effects of activation of an alcohol metabolic gene, cigarette smoking, and alcohol intake on the incidence of metachronous gastric cancer in patients who underwent endoscopic resection for gastric cancer: A multicenter retrospective pilot study.
Satoshi Abiko, Yuichi Shimizu, Marin Ishikawa, Masaki Inoue, Katsuma Nakajima, Risako Kohya, Koji Hirata, Kazuharu Suzuki, Ryo Sugiura, Shuichi Miyamoto, Kenji Kinoshita, Kazuteru Hatanaka, Yoshiya Yamamoto, Hirohito Naruse, Takuto Miyagishima, Naoya Sakamoto
JGH open : an open access journal of gastroenterology and hepatology, 7, 4, 305, 310, 2023年04月, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND AND AIM: Metachronous gastric cancer (GC) frequently occurs in patients who have undergone endoscopic resection (ER) for GC. We evaluated the risk for development of metachronous GC following ER for GC based on genetic polymorphisms for alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2), as well as alcohol consumption and smoking habits. METHODS: We studied 77 patients who underwent ER for GC (median follow-up of 84 months). Genotyping of ADH1B/ALDH2 was performed using saliva sampling. Histories of alcohol consumption and smoking before and after ER and Helicobacter pylori eradication were documented. RESULTS: Multivariate analyses revealed that homozygous slow-metabolizing ADH1B (hazard ratio [HR] = 2.38, P < 0.13), heavy smoking (HR = 2.36, P < 0.09), and cigarette smoking after ER (HR = 2.47, P < 0.10) were not independently associated with the risk of secondary GC development. We analyzed the cessation status of the 38 patients who were classified as heavy smokers before ER based on their smoking habits after the ER and divided them into a cessation group (n = 27, non-smokers after ER) and a non-cessation group (n = 11). Cumulative incidence curves of secondary GC in the cessation and non-cessation groups revealed 5-year incidence rates of 19.0% and 45.0%, respectively (P = 0.02). CONCLUSION: Continued cigarette smoking, at a high level, may be an important risk factor for the development of metachronous GC. Advice for smoking cessation should be given.

A rare case of pancreatic ductal adenocarcinoma with ossification mimicking a pancreatic stone impaction.
Ryo Sugiura, Kiyotaka Sasaki, Hideaki Nakamura, Shoichi Horita, Takashi Meguro, Hidetoshi Kagaya, Tatsuya Yoshida, Hironori Aoki, Takayuki Morita, Miyoshi Fujita, Keisuke Okamura, Eiji Tamoto, Masayuki Fukushima, Takashi Ueno, Akio Tsutaho, Ayano Inoue, Toshiyuki Takahashi
Endoscopic ultrasound, 12, 2, 290, 291, 2023年, ［国際誌］
英語, 研究論文（学術雑誌）

A rare case of pancreatic acinar cell carcinoma presenting a submucosal tumor.
Ryo Sugiura, Hidetoshi Kagaya, Hideaki Nakamura, Shoichi Horita, Takashi Meguro, Kiyotaka Sasaki, Tatsuya Yoshida, Hironori Aoki, Masaki Kuwatani, Masayuki Fukushima, Takayuki Morita, Miyoshi Fujita, Keisuke Okamura, Eiji Tamoto, Takashi Ueno, Akio Tsutaho, Ayano Inoue, Toshiyuki Takahashi
Endoscopic ultrasound, 12, 2, 300, 302, 2023年, ［国際誌］
英語, 研究論文（学術雑誌）

Liver Enzyme Elevation Related to Human Parainfluenza Virus Type 3 Infection.
Yoshimasa Kudo, Tomohiro Wakabayashi, Shuichi Miyamoto, Yuta Sasaoka, Yoshiyuki Sakai, Takeshi Tsugawa
The Pediatric infectious disease journal, 41, 10, e437-e438, 2022年10月01日, ［国際誌］
英語, 研究論文（学術雑誌）, The human parainfluenza viruses are common causes of upper and lower respiratory tract infection; however, nonrespiratory infections with human parainfluenza viruses are rare, and there are no reports of pediatric cases of liver enzyme elevation. We present 2 pediatric patients who developed liver enzyme elevation related to human parainfluenza virus type 3 infection.

Very urgent endoscopic retrograde cholangiopancreatography is associated with early discharge in patients with non-severe acute cholangitis.
Ryo Sugiura, Hirohito Naruse, Yoshiya Yamamoto, Kazuteru Hatanaka, Kenji Kinoshita, Satoshi Abiko, Shuichi Miyamoto, Kazuharu Suzuki, Masayuki Higashino, Risako Kohya, Naoya Sakamoto
Revista espanola de enfermedades digestivas, 114, 3, 133, 139, 2022年03月, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: endoscopic retrograde cholangiopancreatography (ERCP) is a first-line procedure for biliary drainage in patients with acute cholangitis, and there are no studies focused on very urgent ERCP within several hours of hospital arrival. This study aimed to elucidate the use of very urgent ERCP for non-severe acute cholangitis. METHODS: this retrospective observational study included patients with non-severe acute cholangitis who underwent ERCP between April 2011 and June 2020 in our institution. Patients were stratified into three groups based on time to ERCP after hospital arrival: very urgent (≤ 3 hours), urgent (3-24 hours) and elective (> 24 hours). The primary outcome was length of hospital stay (LOS). RESULTS: the study cohort included 291 patients, 168 males (57.7 %), with a median age of 76 (interquartile range, 70-83) years. In all, 47, 196 and 48 patients underwent very urgent, urgent and elective ERCP, respectively. Median LOS in the very urgent, urgent, and elective groups was 12, 14, and 15 days, respectively (Kaplan-Meier method). A shorter LOS was associated with earlier ERCP (log-rank trend test, p = 0.04). The rates of readmission within 30 days of discharge and of adverse events were not significantly different among the three groups. By multivariate analysis, very urgent ERCP was associated with a significantly earlier discharge than urgent and elective ERCP (HR, 0.71, p = 0.04 and HR, 0.47, p < 0.01, respectively). In addition, age ≥ 75 years, pancreatitis, albumin ≤ 2.8 g/dL and two or more ERCP procedures were associated with a significantly longer LOS (HRs < 1, p < 0.05). CONCLUSIONS: very urgent ERCP for non-severe acute cholangitis was associated with early discharge.

Capnocytophaga canimorsus infection led to progressively fatal septic shock in an immunocompetent patient.
Ryuichi Nakayama, Shuichi Miyamoto, Toshihiro Tawara, Arisa Aoyagi, Takeo Oguro, Nobumichi Kobayashi, Michio Suzuki, Yoshihiro Takeyama
Acute medicine & surgery, 9, 1, e738, 2022年, ［国際誌］
英語, BACKGROUND: Capnocytophaga canimorsus infection is rare, with a high fatality rate; however, there are few cases of death with a rapid course. This study reports a progressively fatal case of C. canimorsus. CASE PRESENTATION: A 68-year-old immunocompetent Japanese man was bitten and scratched on his right hand by a dog 6 days before emergency transportation to the emergency room with abdominal pain, back pain, and melena. The patient developed multiple-organ failure. Despite antibiotic therapy, transfusion, vasopressor therapy, and continuous renal replacement therapy, the patient died from uncontrolled metabolic acidosis 4.5 h after admission. Approximately 80 h after admission, blood cultures were positive for C. canimorsus. CONCLUSIONS: Capnocytophaga canimorsus infection can lead to rapid progression even in immunocompetent patients.

Effect of switching from tenofovir disoproxil fumarate to tenofovir alafenamide on lipid profiles in patients with hepatitis B.
Kazuharu Suzuki, Goki Suda, Yoshiya Yamamoto, Satoshi Abiko, Kenji Kinoshita, Shuichi Miyamoto, Ryo Sugiura, Megumi Kimura, Osamu Maehara, Ren Yamada, Takashi Kitagataya, Taku Shigesawa, Masatsugu Ohara, Naoki Kawagishi, Masato Nakai, Takuya Sho, Mitsuteru Natsuizaka, Kenichi Morikawa, Koji Ogawa, Naoya Sakamoto
PloS one, 17, 1, e0261760, 2022年, ［国際誌］
英語, 研究論文（学術雑誌）, For long-term treatment of hepatitis B virus (HBV) infection, switching from tenofovir-disoproxil-fumarate (TDF) to tenofovir-alafenamide (TAF) may prevent renal dysfunction and bone loss. However, the precise effects of this switch on the blood lipid profile remain to be clarified. This is an important issue as TDF is known to have effects on both low- and high-density lipids. Therefore, our retrospective multi-center study aimed to evaluate the effects of switching from TDF to TAF on the lipid profile of patients with HBV infection. Samples were obtained prior to the switch from TDF to TAF and at 6-12 months after TAF initiation. In some cases, additional samples obtained pre- and post-TDF administration were available for analysis. Serum cholesterol levels, including oxidized-low-density lipoprotein (LDL) and non-high-density lipoprotein-cholesterol (HDL-c), and the rate of dyslipidemia, according to the NCEP-ATP III lipid risk classification, were analyzed. The data from 69 patients were analyzed, including 33 patients with pre- and post-TDF-initiation serum samples. Total cholesterol (T-chol), HDL-c, LDL-c, non-HDL-c, and oxidized LDL levels increased significantly after switching to TAF. With regard to sequential changes pre- to post-TAF, TDF was associated with significantly lower serum T-chol, HDL-c, and oxidized LDL-c levels, with T-chol, HDL-c, LDL-c, and oxidized LDL-c levels increasing significantly after the switch. The switch from TDF to TAF was also associated with an increase in the rate of dyslipidemia, from 33% to 39%, with an increase in the rate of severe dyslipidemia of 1.4% and 5.8%, based on T-chol and LDL-c levels. Of note, no cases of severe dyslipidemia were detected pre-TAF treatment. As oxidized LDL-c and non-HDL-c are strongly associated with atherosclerosis development, careful monitoring of lipid is needed after switching from TDF to TAF in this clinical population.

Red dichromatic imaging helps in detecting exposed blood vessels in gastric ulcer induced by endoscopic submucosal dissection.
Shuichi Miyamoto, Ryo Sugiura, Satoshi Abiko, Kazuteru Hatanaka, Yoshiya Yamamoto, Hirohito Naruse, Naoya Sakamoto
Endoscopy, 53, 11, E403-E404, 2021年11月, ［筆頭著者, 責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）

Effectiveness of red dichromatic imaging for dissection of the submucosal layer when hematoma is encountered.
Shuichi Miyamoto, Tomohiko R Ohya, Kaori Nishi, Satoshi Abiko, Ryo Sugiura, Yoshiya Yamamoto, Naoya Sakamoto
Endoscopy, 53, 11, E413-E414, 2021年11月, ［筆頭著者, 責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）

Genomic profiling of intestinal/mixed-type superficial non-ampullary duodenal epithelial tumors.
Shuichi Miyamoto, Goki Suda, Marin Ishikawa, Hideyuki Hayashi, Satoshi Nimura, Yoshihiro Matsuno, Ryo Mori, Shigeki Tanishima, Takahiko Kudo, Tomofumi Takagi, Yoshiya Yamamoto, Shoko Ono, Yuichi Shimizu, Naoya Sakamoto
JGH open : an open access journal of gastroenterology and hepatology, 5, 9, 1071, 1077, 2021年09月, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND AND AIM: The mechanism underlying carcinogenesis and the genomic features of superficial non-ampullary duodenal epithelial tumors (SNADETs) have not been elucidated in detail. In this study, we examined the genomic features of incipient SNADETs, such as small lesions resected via endoscopic treatment, using next-generation sequencing (NGS). METHODS: Twenty consecutive patients who underwent endoscopic treatment for SNADETs of less than 20 mm between January and December 2017 were enrolled. Targeted genomic sequencing was performed through NGS using a panel of 160 cancer-related genes. Furthermore, the alteration/mutation frequencies in SNADETs were examined. RESULTS: The maximum size of the SNADETs examined in this study was 12 mm in diameter. Five SNADETs were classified as low-grade dysplasia (LGD) tumors, while 14 SNADETs were classified as high-grade dysplasia tumors. Only one carcinoma in situ was detected. NGS data for 16 samples were obtained. APC alterations were detected in 81% of samples (13/16). KRAS, BRAF, and TP53 alterations were detected in 25% (4/16), 18.8% (3/16), and 6.3% (1/16) of cases, respectively. CONCLUSION: We detected APC alterations in most small SNADETs resected via endoscopic treatment, from LGD to carcinoma samples. Even in SNADETs classified as small LGD exhibited KRAS and BRAF alterations.

Gastrointestinal: Pediatric pseudo-single magnet ingestion diagnosed by multidirectional X-ray and computed tomography.
T Wakabayashi, S Miyamoto, Y Sasaoka, Y Kudo, S Nakamura, T Noda, Y Kawashima, Y Yamamoto, Y Sakai, Y Kawasaki
Journal of gastroenterology and hepatology, 36, 8, 2035, 2035, 2021年08月, ［責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）

A new endoscopic fixation method using the commercially available Multi-Clamp: the "clamp technique".
Satoshi Abiko, Shuichi Miyamoto, Ryo Sugiura, Kenji Kinoshita, Kazuteru Hatanaka, Yoshiya Yamamoto, Hirohito Naruse
Endoscopy, 53, 8, E301-E302, 2021年08月, ［国際誌］
英語, 研究論文（学術雑誌）

Stereotyped Upper Limb Movement in MECP2 Duplication Syndrome.
Tomohiro Wakabayashi, Shinobu Fukumura, Satoru Takahashi, Kenji Kurosawa, Shuichi Miyamoto, Kosuke Tsuchida, Shinsuke Kato, Takeshi Tsugawa, Yoshiyuki Sakai, Yukihiko Kawasaki
Neurology, 97, 2, 92, 94, 2021年07月13日, ［国際誌］
英語, 研究論文（学術雑誌）

Percutaneous Retrieval of an Inferior Vena Cava Filter Penetrating Into the Duodenum.
Hiroyuki Gibo, Shota Saito, Jiro Koya, Yutaro Yasui, Yusuke Tokuda, Kazuya Sugitatsu, Yasuhiro Makita, Kazuharu Suzuki, Shuichi Miyamoto, Morio Shoda
JACC. Cardiovascular interventions, 14, 12, e131-e133, 2021年06月28日, ［国際誌］
英語, 研究論文（学術雑誌）

A case of Epstein-Barr virus-associated lymphoepithelioma-like carcinoma of the colon.
Hiromi Kanno-Okada, Kenta Takahashi, Harutaka Katano, Ai Shimizu, Emi Takakuwa, Shuichi Miyamoto, Satoshi Abiko, Keiko Yamamoto, Tadakazu Shimoda, Tomoko Mitsuhashi, Hideki Hasegawa, Yoshihiro Matsuno
Pathology international, 71, 6, 420, 426, 2021年06月, ［国際誌］
英語, 研究論文（学術雑誌）, Lymphoepithelioma-like carcinoma is a poorly differentiated carcinoma with prominent lymphoid infiltration occurring in various organs but is exceedingly rare in the colorectal region. This malignancy is frequently associated with Epstein-Barr virus (EBV). Here we report a case of EBV-associated lymphoepithelioma-like carcinoma of the cecum in an 84-year-old male who presented with occult blood. In situ hybridization for EBV-encoded small RNAs (EBER) in an endoscopic submucosal dissection specimen showed that the tumor consisted of EBER-negative well-differentiated tubular adenocarcinoma and EBER-positive lymphoepithelioma-like carcinoma. Real-time PCR detected 7.16 copies of the EBV genome per cell in a sample microdissected from the latter component. Genotyping analysis demonstrated EBV genotype 1, and viral protein/transcript expression in the tumor showed EBV latency I. Expression of Ephrin receptor A2, a recently reported receptor for EBV, was demonstrated in the tumor cells by immunohistochemistry. To our knowledge, this is the first report of lymphoepithelioma-like carcinoma in the colorectal region showing a definite association with EBV infection.

Efficiency of a novel gel product for duodenal ulcer bleeding.
Shuichi Miyamoto, Kazuharu Suzuki, Kenji Kinoshita
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 33, 4, e63-e64, 2021年05月, ［筆頭著者, 責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）

Transient Angioedema of the Small Bowel because of Intravenous Nonionic Iodinated Contrast Media.
Tomohiro Wakabayashi, Yuta Sasaoka, Yoshiyuki Sakai, Shuichi Miyamoto, Takeshi Tsugawa, Yukihiko Kawasaki
The Journal of pediatrics, 230, 264, 265, 2021年03月, ［国際誌］
英語, 研究論文（学術雑誌）

New method of esophageal endoscopic ultrasonography with injected gel: Endoscopic ultrasonography-gel filling method.
Shuichi Miyamoto, Kazuhiro Takahashi, Tomohiko R Ohya
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 33, 3, e49-e50, 2021年03月, ［筆頭著者, 責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）

Triple-loop clip for the traction-assisted colorectal endoscopic submucosal dissection: multidirectional triple-loop traction method.
Shuichi Miyamoto, Tomohiko R Ohya, Masayoshi Ono, Naoya Sakamoto
VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy, 6, 1, 1, 3, 2021年01月, ［筆頭著者, 責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）

Clip with thread attachment prior to incision - new strategy for traction-assisted esophageal endoscopic submucosal dissection.
Shuichi Miyamoto, Tomohiko R Ohya, Masayuki Higashino, Kazuteru Hatanaka, Yoshiya Yamamoto, Hirohito Naruse, Naoya Sakamoto
Endoscopy, 52, 9, E328-E329, 2020年09月, ［筆頭著者, 責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）

Gastrointestinal: Endoscopic myotomy for a large rectal tumor with severe fibrosis after treatment of hemorrhoids
S Miyamoto, J Ito, H Naruse, R Sugiura, Y Yamamoto, K Hatanaka, K Kinoshita, M Higashino, S Hayasaka, N Tsuchida, N Shimoyama, N Sakamoto
Journal of Gastroenterology and Hepatology, 35, 7, 1097, 1097, Wiley, 2020年07月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

New method of endoscopic injection sclerosis for esophageal varices using by modified endoscopic hood.
Shuichi Miyamoto, Yoshiya Yamamoto, Tomofumi Takagi
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 32, 5, e82-e83, 2020年07月, ［筆頭著者, 責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）

Modified method of making a clip with ring-thread for the traction of colorectal endoscopic submucosal dissection.
Shuichi Miyamoto, Jun Ito, Tomohiko R Ohya
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 32, 4, e59-e60, 2020年05月, ［筆頭著者, 責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）

Long-term outcomes and risk factors of recurrent biliary obstruction after permanent endoscopic biliary stenting for choledocholithiasis in high-risk patients.
Ryo Sugiura, Hirohito Naruse, Hiroaki Yamato, Taiki Kudo, Yoshiya Yamamoto, Kazuteru Hatanaka, Jun Ito, Kenji Kinoshita, Shuichi Miyamoto, Masayuki Higashino, Shuhei Hayasaka, Naoya Sakamoto
Journal of digestive diseases, 21, 4, 246, 251, 2020年04月, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVE: To elucidate the long-term outcomes of permanent endoscopic biliary stenting (EBS) and risk factors for recurrent biliary obstruction (RBO) in high-risk or elderly patients with common bile duct (CBD) stones. METHODS: The electronic database of Hakodate Municipal Hospital was searched to identify elderly or high-risk patients with CBD stones who had undergone permanent EBS using a plastic stent without stone removal and were followed up between April 2011 and May 2019, with no further intervention until symptoms occurred. RESULTS: We analyzed a total of 47 patients, of whom 19 (40.4%) were men, with a median age of 86 years (interquartile range 80-90 years). RBO and death without biliary disease occurred in 14 (29.8%) and 19 (40.4%) patients, respectively. The cumulative RBO rates at 20, 40, and 60 months were 22.1%, 31.8%, and 35.5%, respectively. The median time to RBO was 13.0 and 38.0 months in the group with CBD stone  ≥15 mm and 11-14 mm in diameter, respectively. The cumulative RBO incidence rate in the group with CBD stone ≤10 mm in diameter did not reach 50%. The cumulative RBO incidence rates were significantly different among the three groups based on the CBD stone diameter (competing risk analysis, P < 0.01). Multivariate analysis showed that an increase in CBD stone diameter predicted the increased risk of RBO (hazard ratio 1.26, P = 0.01). CONCLUSIONS: Permanent EBS is a feasible option for high-risk patients with small CBD stones.

Hepatobiliary and Pancreatic: Hemosuccus pancreaticus due to an intraductal papillary mucinous neoplasm: A rare cause of obscure gastrointestinal bleeding
R Sugiura, K Kinoshita, H Naruse, Y Yamamoto, K Hatanaka, J Ito, S Miyamoto, M Higashino, S Hayasaka, N Tsuchida, K Nakanishi, S Ueki, M Umehara, N Shimoyama, T Mitsuhashi, N Sakamoto
Journal of Gastroenterology and Hepatology, 35, 3, 363, 363, Wiley, 2020年03月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

表在性非乳頭部十二指腸腫瘍に対するエンドサイトスコピーシステムを用いた分類の検討　　　　　　　　　　　　　　　
宮本 秀一, 工藤 俊彦, 石川 麻倫, 小野 尚子, 清水 勇一, 土田 直央, 早坂 秀平, 東野 真幸, 杉浦 諒, 木下 賢治, 伊藤 淳, 畑中 一映, 山本 義也, 成瀬 宏仁, 坂本 直哉
日本消化器病学会北海道支部例会プログラム・抄録集, 126回, 73, 73, 日本消化器病学会-北海道支部, 2020年03月
日本語

Changes of Dyspeptic Symptom after Successful Eradication in Helicobacter pylori-Associated Dyspepsia.
Momoko Tsuda, Mototsugu Kato, Shoko Ono, Kana Matsuda, Shuichi Miyamoto, Satoshi Abiko, Masayoshi Ono, Takeshi Mizushima, Keiko Yamamoto, Manabu Nakagawa, Katsuhiro Mabe, Soichi Nakagawa, Takahiko Kudo, Keiko Nishikawa, Yuichi Shimizu, Masahiro Asaka, Naoya Sakamoto
Digestion, 101, 2, 165, 173, 2020年, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Helicobacter pylori (H. pylori) gastritis could cause dyspepsia, and eradication is recommended as the first-line treatment. Patients who continuously have their symptoms under control > 6 months after eradication are defined as having H. pylori-associated dyspepsia (HPD), whereas patients who do not benefit from successful eradication are defined as having functional dyspepsia. OBJECTIVES: We assessed changes in dyspeptic symptoms after successful eradication of H. pylori by using a questionnaire. METHODS: We studied H. pylori-infected dyspeptic participants with abdominal symptom scores > 4 points on the Global Overall Symptom (GOS) scoring items and received eradication therapy. We evaluated their symptoms using the GOS questionnaire before their eradications, at 1-month and at 1-year check-ups after eradication therapy. RESULTS: Thirty dyspeptic participants (mean age 59.6 ± 15.3 years) answered every questionnaire. Fourteen participants (46.7%) had HPD, whereas 16 participants (53.3%) were non-HPD patients. The questionnaire at 1 month showed sensitivity of 64.3% (9/14) and specificity of 56.3% (9/16) for HPD. Approximately 60% of H. pylori-infected dyspepsia participants were identified as having HPD or non-HPD within 1 month after their eradications. CONCLUSIONS: Approximately 60% of HPD participants improved at 1 month after eradication. The questionnaire at 1 month helped diagnose HPD in advance and guided next treatment choice.

Esophagitis in Non-Small Cell Lung Carcinoma Treatment Caused by Pembrolizumab.
Sonoe Yoshida, Shuichi Miyamoto, Hirohito Naruse, Jun Ito, Kenji Kinosita, Taiki Kudo, Kazuteru Hatanaka, Yoshiya Yamamoto, Naoya Sakamoto
The American journal of gastroenterology, 115, 1, 13, 13, 2020年01月, ［国際誌］
英語, 研究論文（学術雑誌）

Budesonide foam for prevention of rectal stricture following endoscopic submucosal dissection.
Shuichi Miyamoto, Hirohito Naruse, Naoya Sakamoto
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 31, 5, 588, 588, 2019年09月, ［筆頭著者, 責任著者］, ［国際誌］
英語

Detailed Observation of Fish Tapeworm Using Colonoscopy.
Shuichi Miyamoto, Shuhei Hayasaka, Yoshimasa Kudo, Yuta Sasaoka, Sonoe Yoshida, Kenji Kinoshita, Jun Ito, Taiki Kudo, Kazuteru Hatanaka, Yoshiya Yamamoto, Hirohito Naruse, Naoya Sakamoto
ACG case reports journal, 6, 6, e00086, 2019年06月, ［筆頭著者, 責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）

Evaluation of gastric acid suppression with vonoprazan using calcium carbonate breath test.
Shuichi Miyamoto, Momoko Tsuda, Mototsugu Kato, Katsuhiro Mabe, Shuichi Muto, Shoko Ono, Yuichi Shimizu, Naoya Sakamoto
Journal of clinical biochemistry and nutrition, 64, 2, 174, 179, 2019年03月, ［筆頭著者］, ［国内誌］
英語, 研究論文（学術雑誌）, Vonoprazan, a potassium-competitive acid blocker, is a new class of acid-suppressing agent. The acid-inhibitory effect of vonoprazan has been well-documented. However, there is no report on the extent to which the amount of gastric acid secretion is suppressed, not pH measurement, by the use of vonoprazan. The aim of this study was to evaluate this suppression effect. This was a single-arm, interventional pilot study involving 7 healthy Japanese men. The subjects were administered 20 mg vonoprazan for 6 days. The amount of gastric acid secretion was determined using the calcium carbonate breath test. The acid outputs were defined as the maximum Δ13C‰ (Δ13C max) and area under the curve (AUC) during the 30 min sampling period. The Δ13C max and AUC values significantly decreased on the administration of 20 mg vonoprazan. The AUC dropped by approximately 78% on day 1 and by 84% on day 6 and subsequently returned to the control level after cessation of vonoprazan therapy (reduction by 68% on day 7 and by 42% on day 8). In conclusion, the amount of gastric acid secretion rapidly decreased by the administration of vonoprazan; this inhibitory effect was found to be potent and long-lasting. (UMIN ID: UMIN000025469).

Lavender Color in Linked Color Imaging Enables Noninvasive Detection of Gastric Intestinal Metaplasia
Shoko Ono, Mototsugu Kato, Momoko Tsuda, Shuichi Miyamoto, Satoshi Abiko, Yuichi Shimizu, Naoya Sakamoto
Digestion, 98, 4, 222, 230, S. Karger AG, 2018年11月01日
英語, 研究論文（学術雑誌）, Background and Aims: Recently, there have been some reports that image-enhanced endoscopy may improve detection of gastric intestinal metaplasia (GIM). Our aim was to determine the usefulness of linked color imaging (LCI) for detection of GIM. Methods: In prospectively recruited patients, the whole antrum was observed by white light imaging (WLI) followed by LCI. When a whitish flat elevation (WFE) in WLI and a lavender color sign (LCS) in LCI were detected, target biopsies were performed after LCI. Random biopsies were performed in patients who had neither WFE nor LCS. The primary endpoint was the diagnostic accuracy of GIM per patient in WLI and LCI and the secondary endpoints were that of GIM per biopsy and interobserver agreement. Results: Data from 128 patients were analyzed and 58 patients (45.3%) had histological GIM in the antrum. The per-patient yields of WLI and LCI to detect GIM were 19.0% (11/58) and 91.4% (53/58) respectively. Diagnostic accuracies of target biopsies for GIM were 23.7% in WLI and 84.2% in LCI. Kappa values among 3 doctors were 0.60 for WFE and 0.78 for LCS respectively. Conclusion: LCI could be a new diagnostic tool for detecting GIM during routine endoscopy.

内視鏡を用いた小腸絨毛萎縮診断の正診率についての検討　　　　　　　　　　　　　　　
松田 可奈, 小野 尚子, 石川 麻倫, 宮本 秀一, 安孫子 怜史, 津田 桃子, 山本 桂子, 工藤 俊彦, 清水 勇一, 坂本 直哉
Gastroenterological Endoscopy, 60, Suppl.2, 2123, 2123, (一社)日本消化器内視鏡学会, 2018年10月
日本語

食道癌内視鏡的切除後の異時性多発癌に及ぼす節酒禁煙効果の検討　　　　　　　　　　　　　　　
安孫子 怜史, 清水 勇一, 石川 麻倫, 松田 可奈, 宮本 秀一, 津田 桃子, 山本 桂子, 小野 尚子, 工藤 俊彦, 坂本 直哉
日本消化器病学会雑誌, 115, 臨増大会, A756, A756, (一財)日本消化器病学会, 2018年10月
日本語

Risk assessment of metachronous squamous cell carcinoma after endoscopic resection for esophageal carcinoma based on the genetic polymorphisms of alcoholdehydrogense-1B aldehyde dehydrogenase-2: temperance reduces the risk.
Satoshi Abiko, Yuichi Shimizu, Shuichi Miyamoto, Marin Ishikawa, Kana Matsuda, Momoko Tsuda, Takeshi Mizushima, Keiko Yamamoto, Shoko Ono, Takahiko Kudo, Kota Ono, Naoya Sakamoto
Journal of gastroenterology, 53, 10, 1120, 1130, 2018年10月, ［国内誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Metachronous multiple squamous cell carcinoma (SCC) of the esophagus and the head and neck is commonly observed in patients who have previously undergone endoscopic resection (ER) for SCC of the esophagus (ESCC). We evaluated the risk for developing metachronous SCC following ER for ESCC based on the genetic polymorphisms for alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) as well as the alcohol consumption and smoking habits. METHODS: We studied 158 patients who underwent ER for ESCC (median follow-up 80 months). Genotyping of ADH1B/ALDH2 was performed using saliva sampling. The alcohol consumption and smoking histories of the patients before and after the ER were documented. RESULTS: Multivariate analyses revealed that inactive heterozygous ALDH2 [hazard ratio (HR) 2.25] and alcohol consumption after ER (HR 1.94) were independently associated with the risk of developing secondary SCC. Moreover, inactive heterozygous ALDH2 (HR 4.39) and alcohol consumption after the ER (HR 2.82) were independently associated with the risk of a third SCC. We analyzed 110 patients who had a history of moderate or heavy alcohol consumption before the ER. The 3-year cumulative incidence rates of secondary SCC in the temperance (n = 65) and non-temperance groups (n = 45) were 14.0 and 42.1% (p = 0.0002). Further, the 5-year cumulative incidence rates of a third SCC in the temperance and non-temperance groups were 0 and 15.6% (p = 0.0011), respectively. In addition, the 7-year cumulative incidence rates of a fourth SCC in the temperance and non-temperance groups were 0 and 15.3% (p = 0.0015), respectively. CONCLUSIONS: Continued alcohol consumption is an important risk factor for the onset of metachronous SCC and is a risk factor for the third and subsequent SCCs. Strict advice in favor of temperance is crucial.

Multicenter observational study on functional bowel disorders diagnosed using Rome III diagnostic criteria in Japan.
Masayoshi Ono, Mototsugu Kato, Shuichi Miyamoto, Momoko Tsuda, Takeshi Mizushima, Shouko Ono, Manabu Nakagawa, Katsuhiro Mabe, Soichi Nakagawa, Shuichi Muto, Yuichi Shimizu, Mineo Kudo, Shinichi Katsuki, Takashi Meguro, Naoya Sakamoto
Journal of gastroenterology, 53, 8, 916, 923, 2018年08月, ［国内誌］
英語, 研究論文（学術雑誌）, BACKGROUND: The Rome III diagnostic criteria had been used to diagnose functional gastrointestinal disorders (FGIDs) world wide, and functional bowel disorders (FBDs) including irritable bowel syndrome (IBS) have recently attracted the attention of Japanese physicians. However, there have been few reports on the prevalence of FBDs diagnosed by the Rome III diagnostic criteria. AIMS: The aim of this study was to determine the prevalence of FBDs diagnosed according to the diagnostic criteria of Rome III in Japan. PATIENTS AND METHODS: All patients who were booked for colonoscopy were enrolled from eight institutions in Japan. This study was a prospective observational study in the period from April 2013 to December 2013. Patients filled out FGID questionnaires of Rome III when they were waiting for colonoscopy. RESULTS: Data for 1200 patients who underwent colonoscopy were analyzed. A total of 547 patients (45.6%) were diagnosed with FBDs. Out of those patients, 9.1% had IBS. According to the Rome III diagnostic criteria, 134 patients (11.2%) had functional bloating (FB), 73 (6.1%) had functional constipation (FC), 40 (3.3%) had functional diarrhea (FD), and 191 (15.9%) had unspecified functional bowel disorder (UFBD). Patients with FBDs had significantly higher rates of almost all symptoms (abdominal pain, hard or lumpy stools, loose or watery stools, and bloating) than those in the controls. CONCLUSIONS: In Japan, the prevalence of FBDs and IBS is high, similar to that in the US. Many patients with FBDs have multiple symptoms.

Cecum ulcer is a reliable endoscopic finding in cytomegalovirus colitis concomitant with graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Kana Matsuda, Shoko Ono, Marin Ishikawa, Shuichi Miyamoto, Satoshi Abiko, Momoko Tsuda, Keiko Yamamoto, Takahiko Kudo, Yuichi Shimizu, Eiko Hayase, Daigo Hashimoto, Takanori Teshima, Yoshihiro Matsuno, Naoya Sakamoto
Annals of hematology, 97, 5, 877, 883, 2018年05月, ［国際誌］
英語, 研究論文（学術雑誌）, Although graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), cytomegalovirus (CMV) reactivation also occurs in patients after allo-HSCT and these conditions often clinically overlap. The aim of this study was to determine reliable endoscopic findings of CMV colitis in patients with gastrointestinal graft-versus-host-disease (GI-GVHD). Patients after allo-HSCT who were histologically confirmed to have GI-GVHD with or without CMV colitis and patients with an immunosuppressive condition were retrospectively analyzed. We divided the patients into three groups: GI-GVHD with CMV colitis (group A), GI-GVHD without CMV colitis (group B), and CMV colitis without undergoing allo-HSCT (group C). From medical records, the involved colorectal areas and endoscopic findings according to the groups were compared. A total of 70 patients were divided into three groups (group A: n = 19, group B: n = 28, group C: n = 23). Mucosal injuries in groups A and C frequently occurred in the cecum including ileocecal valves. On the other hand, there were no abnormal lesions on ileocecal valves in group B. Furthermore, ulcer lesions were more frequently observed in groups A and C than in group B (p < 0.001). The sensitivity and specificity of mucosal injuries in the cecum for prediction of CMV colitis were 89.5 and 76.5%, respectively, and mucosal injuries in the cecum were more reliable findings than CMV antigenemia. Ulcer lesions in the cecum are reliable endoscopic findings for CMV colitis in patients with GI-GVHD after allo-HSCT.

咽頭癌CRT後遺残再発に対するサルベージEMR/ESD　　　　　　　　　　　　　　　
安孫子 怜史, 清水 勇一, 石川 麻倫, 松田 可奈, 宮本 秀一, 津田 桃子, 高橋 正和, 山本 桂子, 森 康明, 中川 学, 小野 尚子, 中川 宗一, 工藤 俊彦, 坂本 直哉
Gastroenterological Endoscopy, 60, Suppl.1, 684, 684, (一社)日本消化器内視鏡学会, 2018年04月
日本語

Helicobacter pylori除菌後発見胃癌からみた効率的な内視鏡スクリーニング　　　　　　　　　　　　　　　
津田 桃子, 小野 尚子, 石川 麻倫, 松田 可奈, 宮本 秀一, 安孫子 怜史, 山下 充孝, 高橋 正和, 山本 桂子, 中川 学, 森 康明, 中川 宗一, 工藤 俊彦, 清水 勇一, 坂本 直哉
Gastroenterological Endoscopy, 60, Suppl.1, 696, 696, (一社)日本消化器内視鏡学会, 2018年04月
日本語

Gastric mucosal cracked and cobblestone-like changes resulting from proton pump inhibitor use
Shuichi Miyamoto, Mototsugu Kato, Momoko Tsuda, Kana Matsuda, Tetsuhito Muranaka, Satoshi Abiko, Masayoshi Ono, Takeshi Mizushima, Saori Omori, Keiko Yamamoto, Katsuhiro Mabe, Shoko Ono, Takahiko Kudo, Yuichi Shimizu, Naoya Sakamoto
Gastroenterological Endoscopy, 60, 1, 68, 77, Japan Gastroenterological Endoscopy Society, 2018年01月01日, ［査読有り］
日本語, 研究論文（学術雑誌）, Background and Aim : Use of proton pump inhibitors (PPI) is histologically associated with oxyntic gland dilatations. Two interesting mucosal changes are often detected endoscopically in patients who use PPI : gastric cracked mucosa (GCM) and gastric cobblestone-like mucosa (GCSM). The aim of the present study was to clarify the relationship between PPI use and these mucosal changes. Methods : This was a single-center observational study. All successive subjects who underwent a routine esophagogastroduodenoscopy (EGD) between August and November 2014 in Hokkaido University Hospital were enrolled. Endoscopists carried out the assessment blinded to the use of PPI and checked for GCSM and GCM using original diagnostic criteria for GCM and GCSM. Subjects were divided into two groups : those who used PPI (PPI group) and those who did not (control group). Endoscopic findings and backgrounds were compared between the two groups. Results : A total of 538 patients were analyzed (control group : 374 patients, men/women : 204/170, median age : 65.2 years
PPI group : 164 patients, men/women : 89/75, median age : 67.1 years). GCM was detected in 54 (10.0%) subjects, and GCSM was detected in 18 (3.3%) subjects. There was a significant difference in the prevalence rate of GCM between the control group (14/374, 3.7 %) and the PPI group (40/164, 24.4%) (P<
0.01). GCSM was significantly more prevalent in the PPI group (15/164, 9.1%) than in the control group (3/374, 0.8%) (P<
0.01). Conclusion : Novel GCM and GCSM endoscopic findings in the corpus area seem to be strongly associated with PPI use.

Effects of human amnion-derived mesenchymal stem cells and conditioned medium in rats with sclerosing cholangitis.
Ryo Sugiura, Shunsuke Ohnishi, Masatsugu Ohara, Marin Ishikawa, Shuichi Miyamoto, Reizo Onishi, Koji Yamamoto, Kazumichi Kawakubo, Masaki Kuwatani, Naoya Sakamoto
American journal of translational research, 10, 7, 2102, 2114, 2018年, ［国際誌］
英語, 研究論文（学術雑誌）, Mesenchymal stem cells (MSCs) represent a valuable cell source in regenerative medicine, and large numbers of MSCs can be isolated from the amnion noninvasively. Sclerosing cholangitis is a chronic cholestatic disease and characterized by progressive biliary destruction leading to cirrhosis. Many factors are involved in the development of sclerosing cholangitis; however, effective medical therapy is not established. We investigated the effects of human amnion-derived MSCs (hAMSCs) and conditioned medium (CM) obtained from hAMSC cultures in rats with sclerosing cholangitis. Sclerosing cholangitis was induced via the intragastric administration of 100 mg/kg alpha-naphthylisothiocyanate (ANIT) twice weekly for 4 weeks. One million hAMSCs or 200 μL of CM were intravenously administered on days 15 and 22. Rats were sacrificed on day 29 and evaluated via histological, immunohistochemical, and mRNA expression analyses. hAMSC transplantation and CM administration significantly improved the histological score. In addition, these two interventions significantly improved biliary hyperplasia, peribiliary fibrosis, and inflammation in Glisson's sheath. Accordingly, CK19, MMP-9, and TNF-α, and MCP-1 expression in the liver was also decreased by hAMSC and CM administration. In conclusion, hAMSC and CM administration ameliorated biliary hyperplasia, peribiliary fibrosis, and inflammation in a rat model of sclerosing cholangitis. hAMSCs and CM may represent new modalities for treating sclerosing cholangitis.

Parietal Cell Protrusions and Dilated Oxyntic Glands from Use of Vonoprazan.
Shuichi Miyamoto, Yoshihiro Matsuno, Mototsugu Kato, Takahiko Kudo, Shouko Ono, Yuichi Shimizu, Naoya Sakamoto
The American journal of gastroenterology, 112, 12, 1899, 1901, 2017年12月, ［筆頭著者］, ［国際誌］
英語

Endocytoscopy of Superficial Nonampullary Duodenal Epithelial Tumor: Two Cases of Tubular Adenocarcinoma and Adenoma.
Shuichi Miyamoto, Takahiko Kudo, Satoshi Abiko, Shouko Ono, Yuichi Shimizu, Yoshihiro Matsuno, Naoya Sakamoto
The American journal of gastroenterology, 112, 11, 1638, 1638, 2017年11月, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）

Proton Pump Inhibitor-associated Mucosal Change.
Mototsugu Kato, Shuichi Miyamoto
Internal medicine (Tokyo, Japan), 56, 20, 2697, 2697, 2017年10月15日, ［国内誌］
英語

Enrichment of Helicobacter pylori mutant strains after eradication therapy analyzed by gastric wash-based quantitative pyrosequencing.
Ritsuko Oikawa, Yoshiyuki Watanabe, Shuichi Miyamoto, Yoshinori Sato, Shoko Ono, Katsuhiro Mabe, Hiroyuki Yamamoto, Mototsugu Kato, Fumio Itoh
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 39, 10, 1010428317734865, 1010428317734865, 2017年10月, ［国際誌］
英語, 研究論文（学術雑誌）, The eradication of Helicobacter pylori reduces the risk of gastric cancer. A clear understanding of the factors underlying mixed infection with multiple clarithromycin-susceptible and clarithromycin-resistant H. pylori strains is necessary to design more effective therapies against H. pylori. We aimed to assess how the abundance and prevalence of H. pylori strains vary after clarithromycin-based eradication therapy. Using gastric wash samples, which represent the entire stomach, we sequentially analyzed the abundance and prevalence of H. pylori DNA by 23S ribosomal RNA pyrosequencing before and 1, 2, and 3 years after eradication therapy. Low levels of H. pylori DNA were still detectable at the first-year follow-up in all samples with negative post-treatment urea breath test results. The abundance of H. pylori DNA decreased significantly until the 2-year follow-up, but it switched to an increase at the 3-year follow-up. Importantly, the ratio of the prevalence of mutant strains to the prevalence of wild-type strains had already increased at the first-year follow-up and continued to increase, suggesting the selection and growth of clarithromycin-resistant strains during the follow-up periods. Being sensitive and representative, our assay will be useful in effectively addressing gastric cancer development by enhancing the long-term success of intervention strategies and consecutive surveillance for H. pylori eradication.

MULTICENTER RANDOMIZED CONTROLLED STUDY to ASSESS the EFFECT of PROPHYLACTIC CLIPPING ON POST-POLYPECTOMY DELAYED BLEEDING　　　　　　　　　　　　　　　
Mio Matsumoto, Mototsugu Kato, Koji Oba, Satoshi Abiko, Momoko Tsuda, Shuichi Miyamoto, Takeshi Mizushima, Masayoshi Ono, Saori Omori, Masakazu Takahashi, Shoko Ono, Katsuhiro Mabe, Manabu Nakagawa, Soichi Nakagawa, Takahiko Kudo, Yuichi Shimizu, Naoya Sakamoto
Gastroenterological Endoscopy, 59, 7, 1537, 1545, Japan Gastroenterological Endoscopy Society, 2017年07月01日
日本語, 研究論文（学術雑誌）, Prophylactic clipping has been widely used to prevent post-procedural bleeding in colon polypctomy. However, its efficiency has not been confirmed and there is no consensus on the usefulness of prophylactic clipping. The aim of the present study was to evaluate the preventive effect of prophylactic clipping on post-polypectomy bleeding. Methods : A multicenter randomized controlled study was conducted from January 2012 to July 2013 in Japan. Patients who had polyps <
2 Q cm in diameter were divided into a clipping group and a non-clipping group by cluster randomization. After endoscopic polypectomy, patients allocated to the clipping group underwent prophylactic clipping, whereas the procedure was completed without clipping in patients allocated to the nonclipping group. Occurrence of post-polypectomy bleeding was compared between the two groups. Results : Seven hospitals participated in this study. A total of 3,365 polyps in 1,499 patients were evaluated. The clipping group consisted of 1,636 polyps in 752 patients, and the non-clipping group consisted of 1,729 polyps in 747 patients. Postpolypectomy bleeding occurred in 1.10%" (18/1,636) of the cases in the clipping group, and in 0.87%" (15/1,729) of those in the nonclipping group. The difference was-0.22%" (95%" confidence interval [CI]:-0.96, 0.53). Upper limit of the 95%" CI was lower than the noninferiority margin (1.5%"), and we could thus prove non-inferiority of non-clipping against clipping. Conclusion : Prophylactic clipping is not necessary to prevent post-polypectomy bleeding for polyps <
cm in diameter.

大腸ポリープ切除後のクリップ止血予防に対する多施設共同無作為化比較試験
松本 美桜, 加藤 元嗣, 大庭 幸治, 安孫子 怜司, 津田 桃子, 宮本 秀一, 水島 健, 大野 正芳, 大森 沙織, 高橋 正和, 小野 尚子, 間部 克裕, 中川 学, 中川 宗一, 工藤 俊彦, 清水 勇一, 坂本 直哉
Gastroenterological Endoscopy, 59, 7, 1537, 1545, (一社)日本消化器内視鏡学会, 2017年07月
日本語, 【背景】現在大腸ポリープの切除に際し、切除後の出血予防にクリップをかけることが一般的である。しかし、クリップの有無については術者の裁量に委ねられており、かつ、クリップの出血予防効果についても明らかとはなっていない。今回、クリップの効果を明らかにすべく、われわれは2cm以下のポリープを対象に多施設共同の無作為化比較試験を行った。【方法】検討期間は2004年4月から2013年7月の間、内視鏡的にポリープ切除を行う2cm以下のポリープを持つ20歳以上の患者を対象とし、ポリープ切除後の出血の有無を調査した。肝硬変や透析症例、ヘパリン置換例など重篤な合併症を持つものは除外とした。クリップ施行群ではポリープ切除後に全例でクリップをかけ、非施行群ではクリップを施行せずに処置終了とした。切除時に露出血管または静脈性出血が見られた場合には、スネアの先端で凝固焼灼を追加した上でそれぞれの群に応じた処置を行い終了としたが、動脈性出血が見られた場合には適切な止血処置を行い検討からは除外した。切除後は慎重な経過観察を行い、顕性出血やHb2以上の低下であった場合には緊急内視鏡を行い出血部位を同定した。【結果】北海道の7施設が研究に参加し、1,499人3,365ポリープが解析対象となった。そのうちクリップ群は752人1,636ポリープ、非クリップ群は747人1,729ポリープであった。後出血率はクリップ群で1.10%(18/1,636)、非クリップ群で0.88%(15/1,729)であった。その差は-0.22%(95%Cl:-0.96、0.53)で、95%信頼区間上限が非劣性マージン1.5%を下回り、非クリップ群のクリップ群に対する非劣性が証明された。次いで、クリップ群、非クリップ群それぞれに出血に関わる因子を検討したところ、両群でサイズが有意な因子となった。さらに非クリップ群ではさらに切除後の凝固焼灼の追加も有意なリスク因子であった。【結語】大腸ポリープにおける後出血予防としてのクリップ施行は必ずしも必要でないことが明らかになった。さらに、後出血の危険因子として凝固焼灼の追加が挙げられ、高周波を使用しないコールドポリペクトミーの有用性も示唆された。(著者抄録)

Endoscopic ultrasonography features of gastric mucosal cobblestone-like changes from a proton-pump inhibitor.
Shuichi Miyamoto, Takahiko Kudo, Mototsugu Kato, Kana Matsuda, Satoshi Abiko, Momoko Tsuda, Takeshi Mizushima, Keiko Yamamoto, Shoko Ono, Yuichi Shimizu, Naoya Sakamoto
Clinical journal of gastroenterology, 10, 3, 220, 223, 2017年06月, ［筆頭著者］, ［国内誌］
英語, 研究論文（学術雑誌）, A 68-year-old man with no symptoms presented to Hokkaido University Hospital for esophagogastroduodenoscopy screening. He had a history of Helicobacter pylori eradication. Initial esophagogastroduodenoscopy showed no gastric cobblestone-like mucosa or gastric cracked mucosa. After 1 year, he received esomeprazole (20 mg) once daily for heartburn at another hospital. Esophagogastroduodenoscopy was performed after 2 years of esomeprazole administration. Endoscopic findings showed that after H. pylori eradication, according to the Kyoto classification, gastric cobblestone-like mucosa presented in the gastric body area. Dilation of the oval crypt opening and intervening part in the gastric cobblestone-like mucosa was detected by endoscopy with narrow band imaging. Endoscopic ultrasonography revealed a thick gastric second layer and sporadic small a-echoic lesions in the low-echoic thickened second layer in the gastric cobblestone-like mucosa. The gastric cobblestone-like mucosa biopsy specimen showed parietal cell protrusions and oxyntic gland dilatations. Recently, we reported that gastric mucosal changes such as gastric cracked mucosa and gastric cobblestone-like mucosa were caused by proton-pump inhibitors; however, the gastric cobblestone-like mucosa was not examined by endoscopic ultrasonography. In this case, endoscopic ultrasonography findings suggested that oxyntic gland dilatations caused the elevated gastric mucosa, such as gastric cobblestone-like mucosa, from the use of proton-pump inhibitors.

Gastric mucosal cracked and cobblestone-like changes resulting from proton pump inhibitor use.
Shuichi Miyamoto, Mototsugu Kato, Momoko Tsuda, Kana Matsuda, Tetsuhito Muranaka, Satoshi Abiko, Masayoshi Ono, Takeshi Mizushima, Saori Omori, Keiko Yamamoto, Katsuhiro Mabe, Shoko Ono, Takahiko Kudo, Yuichi Shimizu, Naoya Sakamoto
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 29, 3, 307, 313, 2017年05月, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND AND AIM: Use of proton pump inhibitors (PPI) is histologically associated with oxyntic gland dilatations. Two interesting mucosal changes are often detected endoscopically in patients who use PPI: gastric cracked mucosa (GCM) and gastric cobblestone-like mucosa (GCSM). The aim of the present study was to clarify the relationship between PPI use and these mucosal changes. METHODS: This was a single-center observational study. All successive subjects who underwent a routine esophagogastroduodenoscopy (EGD) between August and November 2014 in Hokkaido University Hospital were enrolled. Endoscopists carried out the assessment blinded to the use of PPI and checked for GCSM and GCM using original diagnostic criteria for GCM and GCSM. Subjects were divided into two groups: those who used PPI (PPI group) and those who did not (control group). Endoscopic findings and backgrounds were compared between the two groups. RESULTS: A total of 538 patients were analyzed (control group: 374 patients, men/women: 204/170, median age: 65.2 years; PPI group: 164 patients, men/women: 89/75, median age: 67.1 years). GCM was detected in 54 (10.0%) subjects, and GCSM was detected in 18 (3.3%) subjects. There was a significant difference in the prevalence rate of GCM between the control group (14/374, 3.7%) and the PPI group (40/164, 24.4%) (P < 0.01). GCSM was significantly more prevalent in the PPI group (15/164, 9.1%) than in the control group (3/374, 0.8%) (P < 0.01). CONCLUSION: Novel GCM and GCSM endoscopic findings in the corpus area seem to be strongly associated with PPI use.

Therapeutic effects of human amnion-derived mesenchymal stem cell transplantation and conditioned medium enema in rats with trinitrobenzene sulfonic acid-induced colitis.
Shuichi Miyamoto, Shunsuke Ohnishi, Reizo Onishi, Ikuki Tsuchiya, Hidetaka Hosono, Takehiko Katsurada, Kenichi Yamahara, Hiroshi Takeda, Naoya Sakamoto
American journal of translational research, 9, 3, 940, 952, 2017年, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, Cell therapy with mesenchymal stem cells (MSCs) is expected to provide a new strategy for the treatment of inflammatory bowel disease (IBD). Large amounts of MSCs can be obtained from human amnion. Therefore, we investigated the effect of transplantation of human amnion-derived MSCs (hAMSCs) or enema of conditioned medium (CM) from hAMSCs into rats with 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. In the first experiment, 10-week-old male Sprague-Dawley rats were intravenously injected with hAMSCs (1 × 106 cells) 3 h after rectal administration of TNBS (45 mg/kg). In the second experiment, rats with TNBS-induced colitis received CM by enema into the colon for 3 days. Colitis was investigated by endoscopy, histology, immunohistochemistry, and by measuring mRNA expression of inflammatory mediators. Administration of hAMSCs or CM enema significantly improved the endoscopic score. In addition, these two interventions resulted in significantly decreased infiltration of neutrophils and monocytes/macrophages and decreased expression levels of TNF-α, CXCL1, and CCL2. In conclusion, transplantation of hAMSCs and CM enema provided significant improvement in rats with TNBS-induced colitis. CM from hAMSCs and hAMSCs may be new strategies for the treatment of IBD.

Gastric Hyperplastic Polyps Associated with Proton Pump Inhibitor Use in a Case without a History of Helicobacter pylori Infection.
Shuichi Miyamoto, Mototsugu Kato, Kana Matsuda, Satoshi Abiko, Momoko Tsuda, Takeshi Mizushima, Keiko Yamamoto, Shoko Ono, Takahiko Kudo, Yuichi Shimizu, Kanako C Hatanaka, Izumi Tsunematsu, Naoya Sakamoto
Internal medicine (Tokyo, Japan), 56, 14, 1825, 1829, 2017年, ［筆頭著者］, ［国内誌］
英語, 研究論文（学術雑誌）, A 56-year-old man with gastroesophageal reflux disease (GERD) was referred to our hospital. Esophagogastroduodenoscopy (EGD) revealed no evidence of any polypoid lesions in the stomach, and the patient had no history of Helicobacter pylori infection. He received omeprazole (20 mg) once daily for the GERD. EGD was performed at 1 year after the start of omeprazole administration, and this time, gastric hyperplastic polyps (GHPs) were detected. The GHPs increased in size as the omeprazole treatment continued, but they markedly decreased in size following omeprazole discontinuation. Thus, the administration of proton pump inhibitors may be a risk factor for the development of GHP independent of H. pylori infection.

Analysis of Helicobacter pylori genotypes in clinical gastric wash samples.
Shuichi Miyamoto, Yoshiyuki Watanabe, Ritsuko Oikawa, Shoko Ono, Katsuhiro Mabe, Takahiko Kudo, Hiroyuki Yamamoto, Fumio Itoh, Mototsugu Kato, Naoya Sakamoto
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 37, 8, 10123, 32, 2016年08月, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, Helicobacter pylori is a key factor in the development of gastric cancer; indeed, clearance of H. pylori helps prevent gastric cancer. However, the relationship between gastric cancer and the abundance and diversity of H. pylori genotypes in the stomach remains unknown. Here, we present, for the first time, a quantitative analysis of H. pylori genotypes in gastric washes. A method was first developed to assess diversity and abundance by pyrosequencing and analysis of single nucleotide polymorphisms in 23S ribosomal RNA (rRNA), a gene associated with clarithromycin resistance. This method was then validated using arbitrarily mixed plasmids carrying 23S rRNA with single nucleotide polymorphisms. Multiple strains were detected in many of 34 clinical samples, with frequency 24.3 ± 24.2 and 26.3 ± 33.8 % for the A2143G and A2144G strains, respectively. Importantly, results obtained from gastric washes were similar to those obtained from biopsy samples. The method provides opportunities to investigate drug resistance in H. pylori and assess potential biomarkers of gastric cancer risk, and should thus be validated in large-scale clinical trials.

Multicenter randomized controlled study to assess the effect of prophylactic clipping on post-polypectomy delayed bleeding.
Mio Matsumoto, Mototsugu Kato, Koji Oba, Satoshi Abiko, Momoko Tsuda, Shuichi Miyamoto, Takeshi Mizushima, Masayoshi Ono, Saori Omori, Masakazu Takahashi, Shoko Ono, Katsuhiro Mabe, Manabu Nakagawa, Soichi Nakagawa, Takahiko Kudo, Yuichi Shimizu, Naoya Sakamoto
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 28, 5, 570, 6, 2016年07月, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND AND AIM: Prophylactic clipping has been widely used to prevent post-procedural bleeding in colon polypctomy. However, its efficiency has not been confirmed and there is no consensus on the usefulness of prophylactic clipping. The aim of the present study was to evaluate the preventive effect of prophylactic clipping on post-polypectomy bleeding. METHODS: A multicenter randomized controlled study was conducted from January 2012 to July 2013 in Japan. Patients who had polyps <2 cm in diameter were divided into a clipping group and a non-clipping group by cluster randomization. After endoscopic polypectomy, patients allocated to the clipping group underwent prophylactic clipping, whereas the procedure was completed without clipping in patients allocated to the non-clipping group. Occurrence of post-polypectomy bleeding was compared between the two groups. RESULTS: Seven hospitals participated in this study. A total of 3365 polyps in 1499 patients were evaluated. The clipping group consisted of 1636 polyps in 752 patients, and the non-clipping group consisted of 1729 polyps in 747 patients. Post-polypectomy bleeding occurred in 1.10% (18/1636) of the cases in the clipping group, and in 0.87% (15/1729) of those in the non-clipping group. The difference was -0.22% (95% confidence interval [CI]: -0.96, 0.53). Upper limit of the 95% CI was lower than the non-inferiority margin (1.5%), and we could thus prove non-inferiority of non-clipping against clipping. CONCLUSION: Prophylactic clipping is not necessary to prevent post-polypectomy bleeding for polyps <2 cm in diameter.

【腸管感染症-最新の話題を含めて】 最近注目される腸管感染症 サイトメガロウイルス腸炎
松田 可奈, 小野 尚子, 石川 麻倫, 宮本 秀一, 安孫子 怜史, 津田 桃子, 山本 桂子, 工藤 俊彦, 清水 勇一, 松野 吉宏, 坂本 直哉, 胃と腸, 53, 4, 446, 450, 2018年04月
＜文献概要＞サイトメガロウイルス(CMV)感染症は易感染性宿主の日和見感染症として知られている.多くは造血幹細胞移植後,自己免疫性疾患や炎症性腸疾患などの免疫抑制状態や易感染状態を背景としてCMV再活性化がみられるが,慢性腎不全や侵襲的な手術後などにも発症しうる.CMV腸炎は消化器症状,内視鏡検査所見および生検による病理組織学的診断をもって診断される.内視鏡像としては打ち抜き様潰瘍が特徴的とされているが,多彩な潰瘍やびらん性病変を呈することが多い.一方で,発赤・浮腫などの非特異的な炎症所見も多く認められる.治療は抗ウイルス薬であるガンシクロビルが第一選択薬となる., (株)医学書院, 日本語

ADH1B/ALDH2遺伝子型と飲酒習慣による食道癌ER後の異時性扁平上皮癌発症リスクの検討
安孫子怜史, 清水勇一, 石川麻倫, 松田可奈, 宮本秀一, 津田桃子, 山本桂子, 小野尚子, 工藤俊彦, 坂本直哉, 日本食道学会学術集会抄録集(CD-ROM), 72nd, 267, 267, 2018年
(NPO)日本食道学会, 日本語

【変わりゆく早期胃癌のスペクトラム-H.pylori未感染・現感染・除菌後は違う!】 H.pylori除菌後、感染既往のある胃癌治療後のサーベイランス
小野 尚子, 石川 麻倫, 松田 可奈, 安孫子 怜史, 津田 桃子, 宮本 秀一, 山本 桂子, 工藤 俊彦, 清水 勇一, 坂本 直哉, 消化器内視鏡, 30, 1, 85, 91, 2018年01月
本邦の多施設共同ランダム化比較試験により「胃癌内視鏡治療後のH.pyloriの除菌治療は異時性胃癌の発生を1/3に減少させる」ことが示されてから、約10年が経過した。異時多発胃癌のリスクは個々の症例で異なるが、特にリスクが高いのは除菌前の高度萎縮、胃癌の既往と高齢男性である。除菌後胃癌の発生部位は、多発性病変を含めてL領域が中心であるが、高度萎縮粘膜では体部や大彎にも病変がみられている。胃癌既往者では既往のない患者に比べて、除菌後の胃癌発生リスクは明らかに高く、除菌後も長期にわたり胃癌を繰り返す症例がある。そのため、サーベイランスは除菌後も長期に継続する必要があり、除菌前の萎縮部位を意識し、画像強調内視鏡を併用して色調差に着目するのが効率的である。(著者抄録), (株)東京医学社, 日本語

プロトンポンプ阻害薬による胃粘膜変化の検討 ひび割れ粘膜と敷石様粘膜　　　　　　　　　　　　　　　
宮本 秀一, 加藤 元嗣, 津田 桃子, 松田 加奈, 村中 徹人, 安孫子 怜史, 大野 正芳, 水島 健, 大森 沙織, 山本 桂子, 間部 克裕, 小野 尚子, 工藤 俊彦, 清水 勇一, 坂本 直哉, Gastroenterological Endoscopy, 60, 1, 68, 77, 2018年01月
【目的】プロトンポンプ阻害薬(以下PPI:Proton pump inhibitor)により胃底腺の拡張や壁細胞の内腔突出といった病理学的変化が報告されている。また、PPI服用者における上部消化管内視鏡検査では、ひび割れ粘膜(以下GCM:Gastric cracked mucosa)や敷石様粘膜(以下GCSM:Gastric cobblestone-like mucosa)などの胃粘膜変化を体部領域に認めることが多いことが知られている。しかし、これらの胃粘膜変化とPPIの関連についての検討はこれまでに報告されておらず、本検討ではPPIと胃粘膜変化(GCM、GCSM)との関連を明らかにすることを目的とする。【方法】単施設、観察研究。対象は2014年8月から2014年11月までに北海道大学病院で上部消化管内視鏡検査を施行した連続症例。内視鏡施行医と画像確認医師2人の合計3人でPPI内服状況を伏せた状態でGCSM、GCMの有無を評価した。対象をPPI服用者(PPI group)とPPI非服用者(Control group)の2つのグループに分け、胃粘膜所見を比較検討した。【結果】除外症例を除き最終的に解析対象症例となったのは538症例(Control group:374人、男性/女性:204人/170人、平均年齢:65.2歳;PPI group:164人、男性/女性:89人/75人、平均年齢:67.1歳)であった。全解析症例の54人(10%)にひび割れ粘膜を認め、18人(3.3%)に敷石様粘膜を認めた。PPI groupでは、ひび割れ粘膜は40人(24.4%)、敷石様粘膜は15人(9.1%)に認め、Control groupと比較し有意差をもってひび割れ粘膜や敷石様粘膜を多く認めた。【結語】PPI服用者にひび割れ粘膜と敷石様粘膜を多く認め、PPIとの関連が示唆された。(著者抄録), (一社)日本消化器内視鏡学会, 日本語

【ここまでできるIEE】 [胃・十二指腸] 精密診断 量的診断(staging) BLIを中心に
小野 尚子, 石川 麻倫, 松田 可奈, 安孫子 怜史, 津田 桃子, 宮本 秀一, 山本 桂子, 工藤 俊彦, 清水 勇一, 坂本 直哉, 消化器内視鏡, 29, 12, 2178, 2185, 2017年12月
拡大内視鏡検査は早期胃癌の範囲診断のうえで最も重要なツールである。レーザー光を使用した狭帯域光画像であるblue laser imagingの波長は、白色光も含まれた多波長であり、被写界深度が大きく、拡大内視鏡観察においても焦点が合わせやすい。近接弱拡大でも表面微細構造は明瞭に観察できることが多く、demarcation lineを同定しやすい。さらに中拡大〜強拡大観察では、微小血管構築と表面微細構造がともに明瞭に視認され、特に表面微細構造の描出に優れていることが特徴である。(著者抄録), (株)東京医学社, 日本語

内視鏡的粘膜下層剥離術後に骨転移をきたした食道表在癌(SM1)の一例　　　　　　　　　　　　　　　
松田 宗一郎, 清水 勇一, 水島 健, 安孫子 怜史, 松田 可奈, 宮本 秀一, 津田 桃子, 坂本 直哉, 高橋 正和, 山本 桂子, 小野 尚子, 森 康明, 中川 学, 中川 宗一, 工藤 俊彦, 北海道医学雑誌, 92, 2, 112, 113, 2017年11月
北海道医学会, 日本語

内視鏡的粘膜下層剥離術後に骨転移をきたした食道表在癌(SM1)の一例　　　　　　　　　　　　　　　
松田 宗一郎, 清水 勇一, 水島 健, 安孫子 怜史, 松田 可奈, 宮本 秀一, 津田 桃子, 坂本 直哉, 高橋 正和, 山本 桂子, 小野 尚子, 森 康明, 中川 学, 中川 宗一, 工藤 俊彦, 北海道医学雑誌, 92, 2, 112, 113, 2017年11月
北海道医学会, 日本語

ヒトとピロリ菌ゲノム解析に基づく"胃全体の情報を網羅した"次世代の胃癌バイオマーカーの開発と診断・治療・予防への応用　　　　　　　　　　　　　　　
山本 博幸, 渡邊 嘉行, 及川 律子, 宮本 秀一, 佐藤 義典, 小野 尚子, 間部 克裕, 加藤 元嗣, 日本癌学会総会記事, 76回, J, 3066, 2017年09月
(一社)日本癌学会, 英語

粘膜下局注併用APCと標準的APCの生体ブタ組織に対する焼灼効果の検討　　　　　　　　　　　　　　　
安孫子 怜史, 清水 勇一, 大西 俊介, 水島 健, 加藤 麻倫, 松田 可奈, 宮本 秀一, 津田 桃子, 山本 桂子, 小野 尚子, 工藤 俊彦, 坂本 直哉, Gastroenterological Endoscopy, 59, Suppl.2, 2223, 2223, 2017年09月
(一社)日本消化器内視鏡学会, 日本語

粘膜下局注併用APCと標準的APCの生体ブタ組織に対する焼灼効果の検討　　　　　　　　　　　　　　　
安孫子 怜史, 清水 勇一, 大西 俊介, 水島 健, 加藤 麻倫, 松田 可奈, 宮本 秀一, 津田 桃子, 山本 桂子, 小野 尚子, 工藤 俊彦, 坂本 直哉, Gastroenterological Endoscopy, 59, Suppl.2, 2223, 2223, 2017年09月
(一社)日本消化器内視鏡学会, 日本語

【胃潰瘍は変わったか-新しい胃潰瘍学の構築を目指して】 H.pylori除菌後の胃潰瘍
小野 尚子, 加藤 元嗣, 松田 可奈, 安孫子 怜史, 津田 桃子, 宮本 秀一, 水島 健, 山本 桂子, 工藤 俊彦, 清水 勇一, 坂本 直哉, 胃と腸, 52, 7, 885, 891, 2017年06月
Helicobacter pylori(H.pylori)除菌は明らかな消化性潰瘍再発予防効果を認めるものの,除菌成功後にもわずかながら潰瘍の発生,再発を認める.その原因はH.pylori再陽性化によるH.pylori潰瘍とH.pyloriに起因しない非H.pylori潰瘍の2つに分かれ,後者は薬剤性潰瘍とりわけアスピリンを含む非ステロイド性抗炎症薬(NSAIDs)潰瘍が大部分を占める.また,原因を特定できない特発性潰瘍もまれながら存在し,その再発率は高い.再発潰瘍への対応としては,酸分泌抑制薬の投与に加え,H.pyloriの再検査,服用薬の確認など潰瘍の誘因を調べることが大切である.(著者抄録), (株)医学書院, 日本語

Beyondボノプラザン標準療法 ペニシリンアレルギーに対するボノプラザンを用いたHelicobacter pylori除菌治療の成績　　　　　　　　　　　　　　　
松田 可奈, 小野 尚子, 宮本 秀一, 津田 桃子, 水島 健, 山本 桂子, 工藤 俊彦, 間部 克裕, 加藤 元嗣, 中川 宗一, 西川 恵子, 日本ヘリコバクター学会学術集会プログラム・抄録集, 23回, 86, 87, 2017年06月
(一社)日本ヘリコバクター学会, 日本語

H.pylori感染胃炎の内視鏡診断の進歩 内視鏡での胃癌リスク評価における画像強調観察の有用性　　　　　　　　　　　　　　　
津田 桃子, 小野 尚子, 松田 可奈, 宮本 秀一, 高橋 正和, 水島 健, 山本 桂子, 中川 学, 中川 宗一, 工藤 俊彦, 日本ヘリコバクター学会学術集会プログラム・抄録集, 23回, 115, 115, 2017年06月
(一社)日本ヘリコバクター学会, 日本語

自己記入問診票からみたH.pylori関連ディスペプシアの特徴　　　　　　　　　　　　　　　
津田 桃子, 加藤 元嗣, 松田 可奈, 宮本 秀一, 山本 桂子, 小野 尚子, 工藤 俊彦, 中川 宗一, 西川 恵子, 間部 克裕, 浅香 正博, 日本ヘリコバクター学会学術集会プログラム・抄録集, 23回, 161, 161, 2017年06月
(一社)日本ヘリコバクター学会, 日本語

除菌後の胃癌表層上皮と周囲粘膜との関係　　　　　　　　　　　　　　　
山本 桂子, 小野 尚子, 松田 可奈, 津田 桃子, 安孫子 怜史, 宮本 秀一, 工藤 俊彦, 日本ヘリコバクター学会学術集会プログラム・抄録集, 23回, 197, 197, 2017年06月
(一社)日本ヘリコバクター学会, 日本語

T1a-MM食道扁平上皮癌EMR/ESD症例の長期予後 5年以上経過例の検討　　　　　　　　　　　　　　　
安孫子 怜史, 清水 勇一, 水島 健, 松田 可奈, 宮本 秀一, 津田 桃子, 山本 桂子, 小野 尚子, 工藤 俊彦, 坂本 直哉, 日本食道学会学術集会プログラム・抄録集, 71回, P20, 1, 2017年06月
(NPO)日本食道学会, 日本語

【Helicobacter pylori除菌後の胃がん予防】 Helicobacter pylori除菌後の胃癌の内視鏡的特徴(2)
山本 桂子, 加藤 元嗣, 松田 可奈, 津田 桃子, 安孫子 怜史, 宮本 秀一, 水島 健, 小野 尚子, 工藤 俊彦, 清水 勇一, 松野 吉宏, 坂本 直哉, Helicobacter Research, 21, 2, 123, 129, 2017年04月
Helicobacter pylori除菌治療が一般に普及するにつれ、除菌では克服できない胃癌の存在が問題として取り上げられるようになった。これらの癌の多くは除菌治療前から存在し、消炎した環境の中で残存、発育した病変である。その内視鏡像は、拡大機能や特殊光を使用した観察においても発見や範囲診断が困難な特徴をもつことが次第に明らかになり、拡大観察像と病理組織像の対比をくり返す努力により、その原因となる病理組織学的な特徴も判明してきた。除菌後発見胃癌の内視鏡的特徴は、除菌前の萎縮、腸上皮化生の状況、癌組織自体の特徴と除菌後の胃内環境変化による影響、除菌消炎後に回復する周囲粘膜の状況などがさまざまに関与して形成されている。(著者抄録), (株)先端医学社, 日本語

サイトメガロウイルス腸炎の内視鏡像 腸管GVHD合併例と非合併例の比較　　　　　　　　　　　　　　　
松田 可奈, 小野 尚子, 宮本 秀一, 安孫子 怜史, 津田 桃子, 水島 健, 山本 桂子, 工藤 俊彦, 清水 勇一, 坂本 直哉, Gastroenterological Endoscopy, 59, Suppl.1, 1024, 1024, 2017年04月
(一社)日本消化器内視鏡学会, 日本語

胃発癌リスクマーカーとしての同一症例における胃内ピロリ菌複数種の混在比検討
及川 律子, 渡邊 嘉行, 宮本 秀一, 小野 尚子, 間部 克裕, 山本 博幸, 加藤 元嗣, 伊東 文生, 日本分子腫瘍マーカー研究会誌, 32, 61, 62, 2017年03月
日本分子腫瘍マーカー研究会, 日本語

当院における除菌後発見胃癌の臨床病理学的再評価　　　　　　　　　　　　　　　
山本 桂子, 安孫子 怜史, 宮本 秀一, 水島 健, 小野 尚子, 工藤 俊彦, 清水 勇一, 松田 可奈, 津田 桃子, 坂本 直哉, 胃病態機能研究会誌, 49, 17, 17, 2017年02月
胃病態機能研究会, 日本語

当院で内視鏡治療を施行したT1a-MM食道扁平上皮癌の長期予後　　　　　　　　　　　　　　　
水島 健, 清水 勇一, 宮本 秀一, 安孫子 怜史, 津田 桃子, 大野 正芳, 村中 徹人, 中積 宏之, 坂本 直哉, 高橋 正和, 小野 尚子, 中川 学, 中川 宗一, 小松 嘉人, 北海道医学雑誌, 91, 2, 91, 91, 2016年11月
北海道医学会, 日本語

同一症例胃内におけるピロリ菌複数種混在比の検討　　　　　　　　　　　　　　　
及川 律子, 宮本 秀一, 渡邊 嘉行, 小野 尚子, 間部 克裕, 山本 博幸, 加藤 元嗣, 伊東 文生, 日本癌学会総会記事, 75回, P, 2049, 2016年10月
(一社)日本癌学会, 英語

下咽頭上皮下浸潤癌EMR/ESD施行症例の病理組織学的検討　　　　　　　　　　　　　　　
安孫子 怜史, 清水 勇一, 水島 健, 松田 可奈, 宮本 秀一, 津田 桃子, 高橋 正和, 山本 桂子, 森 康明, 中川 学, 小野 尚子, 中川 宗一, 工藤 俊彦, 坂本 直哉, Gastroenterological Endoscopy, 58, Suppl.2, 1990, 1990, 2016年10月
(一社)日本消化器内視鏡学会, 日本語

胃発癌リスクマーカーとしての同一症例における胃内ピロリ菌複数種の混在比検討　　　　　　　　　　　　　　　
及川 律子, 渡邊 嘉行, 宮本 秀一, 小野 尚子, 間部 克裕, 山本 博幸, 加藤 元嗣, 伊東 文生, 日本分子腫瘍マーカー研究会プログラム・講演抄録, 36回, 84, 85, 2016年09月
日本分子腫瘍マーカー研究会, 日本語

【H.pylori除菌後の諸問題】 H.pylori除菌がGERD発症にどのように影響するのか　　　　　　　　　　　　　　　
加藤 元嗣, 小野 尚子, 中川 学, 中川 宗一, 安孫子 怜史, 宮本 秀一, 水島 健, 津田 桃子, 大野 正芳, 大西 俊介, 清水 勇一, 坂本 直哉, 間部 克裕, The GI Forefront, 11, 2, 106, 109, 2016年01月
H.pylori感染は胃酸分泌との関わりからGERDの影響因子である。実際、H.pylori感染率とGERD有病率については相反する関係にあり、H.pylori感染がGERD発症に防御的に作用している可能性がある。一方、H.pylori除菌がGERDの発症を増加させるかについては、いくつかのメタ解析の結果から否定的である。むしろ、GERD症状はH.pylori除菌によって軽減する傾向がある。したがって、GERDの存在がH.pylori除菌の妨げとはならない。(著者抄録), (株)メディカルレビュー社, 日本語

【慢性胃炎を見直す】 胃炎の内視鏡診断 通常光観察　　　　　　　　　　　　　　　
加藤 元嗣, 小野 尚子, 中川 学, 中川 宗一, 安孫子 怜史, 宮本 秀一, 水島 健, 津田 桃子, 大野 正芳, 大西 俊介, 清水 勇一, 坂本 直哉, 間部 克裕, 胃と腸, 51, 1, 42, 51, 2016年01月
組織学的所見と内視鏡所見が一致しないために,慢性胃炎はこれまで組織学的に診断されてきた.しかし,最近の内視鏡機器の進歩により,組織学的胃炎と一致する内視鏡所見が次第に明らかになった.胃粘膜におけるH. pylori感染状態は,H. pylori未感染,H. pylori感染,H. pylori既感染・除菌後に分けることができる.新たな内視鏡による胃炎分類である京都分類では,19の胃炎所見を定義して,H. pylori感染状態との関連性を整理した.RAC,びまん性発赤,地図状発赤は,それぞれH. pylori未感染,H. pylori感染,H. pylori除菌後の特徴的な所見である.H. pylori感染状態によって,発生胃癌のリスクや特徴は異なるため,胃炎の診断は胃癌スクリーニングにおいても重要である.(著者抄録), (株)医学書院, 日本語

Novel Gastric Gastric Mucosal Changes Induced by Use of Pproton Pump Inhibitor
Shuichi Miyamoto, Mototsugu Kato, Shouko Ono, Katsuhiro Mabe, Yuichi Shimizu, Naoya Sakamoto, GASTROINTESTINAL ENDOSCOPY, 81, 5, AB465, AB465, 2015年05月
MOSBY-ELSEVIER, 英語, 研究発表ペーパー・要旨（国際会議）

最速で身につける!消化器内視鏡の基本テクニック : とことんシンプルな解説とビジュアルでわかる操作の基本
宮本, 秀一
羊土社, 2024年06月, 9784758110822, 151p, 日本語, ［単著］

〔主要な業績〕Endoskopi Teknik och praktik　　　　　　　　　　　　　　　
Shuichi Miyamoto, All
Tillotts pharma Sweden, 2023年05月, 9789152765036, ［単著］

〔主要な業績〕安全に施行するためのESDテクニック
宮澤, 光男, 大西, 俊介, 視野確保の工夫-送気・吸引を使いこなそう(p146-p147)、トラクションデバイスの効果的な使い方(p148-151)
医学書院, 2022年04月, 9784260048613, xi, 162p, 日本語, ［共著］

The evaluation of the modified traction assisted endoscopic submucosal dissection with attachment of traction clip prior to making mucosal flap.　　　　　　　　　　　　　　　
S. Miyamoto, T.R. Ohya, S. Willmarson, D. Oikonomou, J. Zhu, L. Longer, T. Andersson-Thell, H. Björkenbeck, M. Higashino, M. Ono, S. Ono, Y. Yamamoto, N. Sakamoto
UEG Week 2022, 2022年10月, 英語, ポスター発表

Effects of Human Amnion-Derived Mesenchymal Stem Cell Transplantation and Conditioned Medium Enema in rats with trinitrobenzene sulfonic acid-induced colitis　　　　　　　　　　　　　　　
Miyamoto S, Ohnishi S, Tsuchiya I, Onishi R, Hosono H, TakedaH, Sakamoto N
UEG Week 2016, 2016年10月, ポスター発表

Novel gastric mucosal changes induced by use of proton pump inhibitor.　　　　　　　　　　　　　　　
Miyamoto S, Kato M, Abiko S, Ono M, Tsuda M, Omori S, Mizushima T, Mori Y, Ono S, Nakagawa M, Mabe K, Nakagawa S, Shimizu Y, Sakamoto N
Digestive Disease Week 2015, 2015年05月, ポスター発表

2013年04月 - 現在
日本消化器病学会　　　　　　　　　　　　　　　

2012年01月 - 現在
日本消化器内視鏡学会　　　　　　　　　　　　　　　

2011年05月 - 現在
日本内科学会