Dual Mechanism of Action: Exosomes from Human iPSC-Cardiomyocytes and Mesenchymal Stem Cells Restore Injured Myocardium
Eileen Tzng, Nathan Bayardo, Gentaro Ikeda, Hiroyuki Takashima, Jennifer Lyons, Mihoko Bennett, Connor G O’Brien, Phillip C. Yang
30 May 2024

Platelet-rich plasma does not accelerate the healing of damaged muscle following muscle strain
Fusagawa, H., Yamada, T., Sato, T., Ashida, Y., Teramoto, A., Takashima, H., Naito, A., Tokuda, N., Yamauchi, N., Ichise, N., Ogon, I., Yamashita, T., Tohse, N.
Journal of Orthopaedic Research, 42, 6, 2024
Scientific journal

Specific pelvic shape in patients with developmental dysplasia of the hip on 3D morphometric homologous model analysis.
Yui Sasaki, Daisuke Suzuki, Ryo Tokita, Hiroyuki Takashima, Hirofumi Matsumura, Satoshi Nagoya
PloS one, 19, 6, e0300938, 2024, [International Magazine]
English, Scientific journal, PURPOSE: To clarify the morphological factors of the pelvis in patients with developmental dysplasia of the hip (DDH), three-dimensional (3D) pelvic morphology was analyzed using a template-fitting technique. METHODS: Three-dimensional pelvic data of 50 patients with DDH (DDH group) and 3D pelvic data of 50 patients without obvious pelvic deformity (Normal group) were used. All patients were female. A template model was created by averaging the normal pelvises into a symmetrical and isotropic mesh. Next, 100 homologous models were generated by fitting the pelvic data of each group of patients to the template model. Principal component analysis was performed on the coordinates of each vertex (15,235 vertices) of the pelvic homologous model. In addition, a receiver-operating characteristic (ROC) curve was calculated from the sensitivity of DDH positivity for each principal component, and principal components for which the area under the curve was significantly large were extracted (p<0.05). Finally, which components of the pelvic morphology frequently seen in DDH patients are related to these extracted principal components was evaluated. RESULTS: The first, third, and sixth principal components showed significantly larger areas under the ROC curves. The morphology indicated by the first principal component was associated with a decrease in coxal inclination in both the coronal and horizontal planes. The third principal component was related to the sacral inclination in the sagittal plane. The sixth principal component was associated with narrowing of the superior part of the pelvis. CONCLUSION: The most important factor in the difference between normal and DDH pelvises was the change in the coxal angle in both the coronal and horizontal planes. That is, in the anterior and superior views, the normal pelvis is a triangle, whereas in DDH, it was more like a quadrilateral.

Quantitative assessment of anterior talofibular ligament quality in chronic lateral ankle instability using magnetic resonance imaging T2* value.
Yoshihiro Akatsuka, Atsushi Teramoto, Yasutaka Murahashi, Katsunori Takahashi, Rui Imamura, Hiroyuki Takashima, Kota Watanabe, Toshihiko Yamashita
Skeletal radiology, 20 Oct. 2023, [International Magazine]
English, Scientific journal, OBJECTIVE: To determine T2* normal reference values for anterior talofibular ligament (ATFL) and to investigate the feasibility of the quantitative ATFL quality evaluation in chronic lateral ankle instability (CLAI) using T2* values. MATERIALS AND METHODS: This study enrolled 15 patients with CLAI and 30 healthy volunteers. The entire ATFL T2* values from the MRI T2* mapping were measured. The prediction equation (variables: age, height, and weight) in a multiple linear regression model was used to calculate the T2* normal reference value in the healthy group. T2* ratio was defined as the ratio of the actual T2* value of the patient's ATFL to the normal reference value for each patient. A Telos device was used to measure the talar tilt angle (TTA) from the stress radiograph. RESULTS: T2* values of ATFL in the healthy and CLAI groups were 10.82 ± 1.84 ms and 14.36 ± 4.30 ms, respectively, which are significantly higher in the CLAI group (P < 0.05). The prediction equation of the normal reference T2* value was [14.9 + 0.14 × age (years) - 4.7 × height (m) - 0.03 × weight (kg)] (R2 = 0.65, P < 0.0001). A significant positive correlation was found between the T2* ratio and TTA (r = 0.66, P = 0.007). CONCLUSION: MRI T2* values in patients with CLAI were higher than those in healthy participants, and the T2* ratio correlated with TTA, suggesting that T2* values are promising for quantitative assessment of ATFL quality preoperatively.

Coefficient of variation of T2-weighted MRI may predict the prognosis of malignant peripheral nerve sheath tumor.
Makoto Emori, Hiroyuki Tsuchie, Hiroyuki Takashima, Atsushi Teramoto, Yasutaka Murahashi, Yoshinori Imura, Hidetatsu Outani, Sho Nakai, Satoshi Takenaka, Ryosuke Hirota, Naoya Nakahashi, Junya Shimizu, Kazuyuki Murase, Akira Takasawa, Hiroyuki Nagasawa, Shintaro Sugita, Kohichi Takada, Tadashi Hasegawa, Seiji Okada, Naohisa Miyakoshi, Toshihiko Yamashita
Skeletal radiology, 27 Sep. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: We investigated whether non-enhancement MRI features, including measurement of the heterogeneity of the tumor with MR T2 imaging by calculating coefficient of variation (CV) values, were associated with the prognosis of non-metastatic malignant peripheral nerve sheath tumors (MPNST). METHODS: This retrospective study included 42 patients with MPNST who had undergone surgical resection (mean age, 50 years ± 21; 20 male participants). Non-enhancement MR images were evaluated for signal intensity heterogeneity on T1- and T2-weighted imaging, tumor margin definition on T1- and T2-weighted imaging, peritumoral edema on T2-weight imaging, and CV. We measured the signal intensities of MR T2-weighted images and calculated the corresponding CV values. CV is defined as the ratio of the standard deviation to the mean. The associations between factors and overall survival (OS) were investigated via the Kaplan-Meier method with log-rank tests and the Cox proportional hazards model. RESULTS: The mean CV value of MR T2 images was 0.2299 ± 0.1339 (standard deviation) (range, 0.0381-0.8053). Applying receiver operating characteristics analysis, the optimal cut-off level for CV value was 0.137. This cut-off CV value was used for its stratification into high and low CV values. At multivariate survival analysis, a high CV value (hazard ratio = 3.63; 95% confidence interval = 1.16-16.0; p = 0.047) was identified as an independent predictor of OS. CONCLUSION: The CV value of the signal intensity of heterogenous MPNSTs MR T2-weighted images is an independent predictor of patients' OS.

Osteophyte Bridge Formation Correlates with Vascular Calcification and Cardiovascular Disease in Diffuse Idiopathic Skeletal Hyperostosis
Ryosuke Hirota, Atsushi Teramoto, Mitsunori Yoshimoto, Hiroyuki Takashima, Naomi Yasuda, Arihiko Tsukamoto, Noriyuki Iesato, Makoto Emori, Kousuke Iba, Nobuyoshi Kawaharada, Toshihiko Yamashita
Journal of Clinical Medicine, 12, 16, Aug. 2023
Scientific journal, Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory spondyloarthropathy characterized by ectopic calcification of spinal cord tissue. Its etiology is possibly polygenic. However, its pathogenesis and systemic effects remain unclear. Recent studies have reported a high prevalence of DISH in heart failure patients. The authors investigated how the incidence and severity of DISH are associated with vascular calcification and the occurrence of cardiovascular events. In this retrospective chart review study, 500 patients with cardiovascular disease who underwent surgery (cardiovascular events group) and 500 patients with non-cardiovascular disease who underwent computed tomography scans (non-cardiovascular events group) were randomly selected to investigate the degree of ossification of the anterior longitudinal ligament and the incidence of DISH. We found that the incidence of DISH was higher in patients with cardiovascular events and that patients with DISH had more calcification of the coronary arteries and aorta. Next, we examined the relationship between the degree of coronary and aortic calcification, the incidence of DISH, and the degree of ossification of the anterior longitudinal ligament in the non-cardiovascular event group. The prevalence of DISH in the cardiovascular and non-cardiovascular groups was 31.4% and 16.5%, respectively (p = 0.007). Aortic calcification and a predominant degree of vascular calcification with a certain level of ossification of the anterior longitudinal ligament suggest some correlation between DISH and cardiovascular events. This study is important in understanding the pathophysiology and pathogenesis of DISH.

Quantitative magnetic resonance spectroscopy and imaging analysis of the lipid content in the psoas major and its association with intervertebral disc degeneration: a cross-sectional study
Izaya Ogon, Hiroyuki Takashima, Tomonori Morita, Mitsunori Yoshimoto, Tsuneo Takebayashi, Atsushi Teramoto
Exploration of Musculoskeletal Diseases, 29 Jun. 2023
Scientific journal

Does the L4 nerve root extend during femoral nerve stretch test? A cadaveric study of four cases analyzing the extension rates of the lumbar nerve root.
Izaya Ogon, Tsuneo Takebayashi, Hironori Chiba, Hiroyuki Takashima, Tomonori Morita, Atsushi Teramoto
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 02 Jun. 2023, [Domestic magazines]
English, Scientific journal, BACKGROUND: Lumbar radicular pain is a common symptom of lumbar disc herniation and spinal canal stenosis, and L4 nerve root impingement is difficult to diagnose. This study aimed to elucidate the extension rate of L4 nerve roots in Thiel-embalmed specimens using both classic and new femoral nerve stretch test (FNST), as well as straight leg raising test (SLRT). Additionally, the extension rate of the L2 and L3 nerve roots and L5 and S1 roots were determined using FNST (both classic and new) and SLRT, respectively. METHODS: Four Thiel-embalmed specimens were used. The extension rate data of the nerve root were obtained using a displacement sensor under the following conditions: knee joint flexed to 0°/45°/90°/135° with either the hip extension/flexion of 0° (classic FNST) or extension of 15° (new FNST); and hip joint flexed to 0°/30°/60°/90° with the knee flexion of 0° (SLRT). RESULTS: Case A had almost no L4 nerve root lengthening at 45° and 90° knee joint flexion; however, at 135° of knee flexion, the nerve root was lengthened. In Case B, the L4 nerve root was hardly extended by the classic FNST, but it was extended at 135° of knee flexion and 15° of hip extension. In Case C, the L4 nerve root showed little change by classic FNST and it was shortened by new FNST, whereas, it was extended by SLRT. Case D showed a shortened L4 nerve root at 135° of knee flexion in classic FNST and at 0°/45°/90°/135° of knee flexion and 15° of hip extension. Further, no root shortening was observed for L2 and L3 nerve roots according to both classic and new FNST. In contrast, the extension of L2 and L3 nerve root with the new FNST was high. In all cases, nerve roots were lengthened by the SLRT. Further, as the hip flexion angle increased, the rate of nerve elongation also increased. CONCLUSIONS: It was shown that in patients in whom L4 nerve root was extended by FNST, it was shortened by SLRT. The opposite pattern was also observed. Further, it is believed that FNST and SLRT are reliable tests for L2 and L3 radiculopathy and L5 and S1 radiculopathy, respectively, and that more tension on the femoral and sciatic nerves is better. Furthermore, we recommend that FNST should be performed with 15° hip extension and 135° knee flexion to improve the diagnostic accuracy.

Intravoxel Incoherent Motion Factors Affecting Collapse and Nonunion of Osteoporotic Vertebral Fracture.
Izaya Ogon, Tsuneo Takebayashi, Hiroyuki Takashima, Yasuhisa Abe, Hiroshi Oguma, Rui Imamura, Yoshihiro Akatsuka, Tomonori Morita, Atsushi Teramoto
Global spine journal, 21925682231167788, 21925682231167788, SAGE PUBLICATIONS LTD, 31 Mar. 2023, [International Magazine]
English, Scientific journal, STUDY DESIGN: Longitudinal study. OBJECTIVES: Intravoxel incoherent motion (IVIM), a magnetic resonance imaging (MRI) scanning technique that applies diffusion-weighted imaging (DWI), is effective for the quantitative assessment of malignant tumors of the vertebral bone. We hypothesized that IVIM parameters of vertebral bodies are associated with the prognosis of osteoporotic vertebral fracture (OVF). We aimed to explore the relationships between IVIM parameters for vertebral collapse and non-union after OVF and calculate the cut-off values of these parameters for vertebral collapse and non-union. METHODS: A total of 150 patients with acute OVF (150 women; mean age: 79.1 ± 7.4 years) were included and treated conservatively with bracing. MRI was performed at the time of injury. IVIM parameters, such as apparent diffusion coefficient (ADC), molecular diffusion coefficient (D), and perfusion-related diffusion (D*) were recorded. The patients were classified into 3 groups: low-collapse (height loss of ≤50%), high-collapse (height loss of >50%), and non-union. We compared ADC, D, and D* among the low-collapse, high-collapse, and non-union groups and performed a receiver operating characteristic (ROC) curve analysis to determine the boundary values of the high-collapse and non-union groups. RESULTS: The low-collapse, high-collapse, and non-union groups had no significant differences in ADC and D. However, D* differed significantly among the 3 groups. ROC analysis revealed cut-off values of 19.0 × 10-3 mm2/s and 12.3 × 10-3 mm2/s for the high-collapse and non-union groups, respectively. CONCLUSIONS: D* is a significant prognostic indicator for high-collapse and non-union groups with OVF. This suggests that D* should be considered when assessing OVF.

T1rho, T2, and T2* relaxation time based on grading of intervertebral disc degeneration.
Hiroyuki Takashima, Mitsunori Yoshimoto, Izaya Ogon, Tsuneo Takebayashi, Rui Imamura, Yoshihiro Akatsuka, Toshihiko Yamashita
Acta radiologica (Stockholm, Sweden : 1987), 64, 3, 1116, 1121, SAGE PUBLICATIONS LTD, Mar. 2023, [Lead author, Corresponding author], [International Magazine]
English, Scientific journal, BACKGROUND: Previous studies have explored the biochemical changes of disc degeneration and its relevance in low back pain using various quantitative magnetic resonance imaging (MRI) techniques. However, quantitative evaluation of intervertebral disc (IVD) with MRI such as T1rho, T2, and T2* have not been previously analyzed and compared directly in the same patients. PURPOSE: To investigate T1rho, T2, and T2* of IVD degeneration in the same patients, reveal the correlation coefficients of these values, and evaluate which values are more sensitive to detect the degree of IVD degeneration. MATERIAL AND METHODS: The participants were 55 patients who underwent MRI examinations which the investigator classified the degree of IVD degeneration according to the Pfirrmann classification. The T1rho, T2, and T2* values of IVD were analyzed for their classification and were compared. RESULTS: T1rho, T2, and T2* values were 74.3 ± 7.1, 61.2 ± 6.7, and 46.5 ± 16.3 ms (grade II); 61.6 ± 11.8, 48.9 ± 8.2, and 34.1 ± 11.8 ms (grade III); 50.8 ± 10.8, 38.9 ± 9.8, and 25.4 ± 8.1 ms, (grade IV); 44.5 ± 13.3, 34.8 ± 9.5, and 11.2 ± 6.6 ms (grade V), respectively. Those values significantly decreased with increasing grades, but T1rho and T2 values for grades IV and V were not different. CONCLUSION: The T1rho and T2 values were excellent for the evaluation of initial to moderate IVD degeneration with water and proteoglycan content. In contrast, the T2* value was suitable for detailed evaluation of progressive IVD, even with poor water content.

Comparison of the three-dimensional bone morphology of the first proximal phalanx and first metatarsal between normal and hallux valgus foot using the homologous model technique.
Kenta Yamatsu, Mizuho Hayashi, Hiroyuki Takashima, Kota Watanabe
Foot (Edinburgh, Scotland), 54, 101968, 101968, Mar. 2023, [International Magazine]
English, Scientific journal, Bone morphology is one of the factors involved in hallux valgus development. However, previous studies have not evaluated the overall bone shape in three dimensions. This study aimed to compare the overall shape of the first proximal phalanx and first metatarsal in hallux valgus with those of normal feet.Homologous models were created from computed tomography data of the first proximal phalanx and first metatarsal of 75 healthy men and 53 women in the control group and 10 men and 71 women in the hallux valgus group. Principal component analysis was performed to examine the differences in bone morphology between the control and hallux valgus groups. In men and women with hallux valgus, the proximal articular surface of the first proximal phalanx was characterized by a more lateral inclination and torsion of the pronated first metatarsal. Additionally, the first metatarsal head was characterized by a more lateral inclination in male hallux valgus. This study is the first to reveal the morphological characteristics of the first metatarsal and first proximal phalanx in hallux valgus as a whole bone using a homologous model technique. These characteristics are considered possible causes of hallux valgus development. The shapes of the first proximal phalanx and first metatarsal in hallux valgus were different from those in normal feet. This finding should be useful when considering the pathogenesis and treatment development for hallux valgus.

Relationships of cross-sectional area of the thigh muscles before or after total knee arthroplasty with postoperative pain or patient satisfaction: A retrospective, exploratory study
Akatsuka, Y., Teramoto, A., Takashima, H., Okada, Y., Watanabe, K., Yamashita, T.
Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, 33, 2023
Scientific journal

Association of central sensitization, visceral fat, and surgical outcomes in lumbar spinal stenosis
Ogon, I., Takashima, H., Morita, T., Fukushi, R., Takebayashi, T., Teramoto, A.
Journal of Orthopaedic Surgery and Research, 18, 1, 2023
Scientific journal

Mitochondria-Rich Extracellular Vesicles From Stem Cell-Derived Cardiomyocytes Restore Cardiac Energy Metabolism of Ischemic Myocardium in a Preclinical Pig Model
Gentaro Ikeda, Hiroyuki Takashima, Chunli Zhao, Nathan Bayardo, Jennifer Lyins, Connor O'Brien, Phillip C. Yang
CIRCULATION, 146, LIPPINCOTT WILLIAMS & WILKINS, Nov. 2022
English, 0

Manganese-Enhanced MRI (MEMRI) Determines the Mechanistic Efficacy of Exosome Therapy in a Porcine Myocardial Infarction Model
Hiroyuki Takashima, Gentaro Ikeda, Chunli Zhao, Nathan Bayardo, Connor O'Brien, Phillip C. Yang
CIRCULATION, 146, LIPPINCOTT WILLIAMS & WILKINS, Nov. 2022, [Lead author]
English, 0

感染拡大防止を目的とした感染症患者検査時の感染箇所の同定と清拭消毒方法の検討　　　　　　　　　　　　　　　
高島 弘幸
医療の広場, 62, 8, 9, 11, (公財)政策医療振興財団, Aug. 2022, [Lead author, Last author, Corresponding author]
Japanese, 新型コロナウイルス感染症患者の肺炎の重症度などを判断する目的で幅広く利用されているCT検査室における、感染患者対応時の接触感染の原因となる箇所を明らかにすることを目的に、蛍光塗料を塗布したディスポーザブル長袖エプロン及び手袋等を装着した感染模擬患者を、実際の検査時と同様に標準予防策を施した医療者がCT寝台に移乗する介助を行い、実際の診療を想定した行為(酸素投与、造影剤投与、寝台操作および撮影等)後の、CT検査室内及び操作室をブラックライトで照射し、蛍光塗料付着部を汚染箇所としてカメラで撮影し、その箇所及び面積を計測した。その結果、汚染箇所は、とくにCT検査室内で大きく、CT装置の寝台の蛍光塗料付着が最も大きく、以下、造影剤投与インジェクター、ドアノブの順であった。

Factors associated with low back pain in patients with lumbar spinal stenosis: a cross-sectional study.
Izaya Ogon, Atsushi Teramoto, Hiroyuki Takashima, Yoshinori Terashima, Mitsunori Yoshimoto, Makoto Emori, Kousuke Iba, Tsuneo Takebayashi, Toshihiko Yamashita
BMC musculoskeletal disorders, 23, 1, 552, 552, BMC, 08 Jun. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: Low back pain (LBP) is a major symptom of symptomatic lumbar spinal stenosis (SLSS). It is important to assess LBP in patients with SLSS to develop better treatment. This study aimed to analyse the factors associated with LBP in patients with SLSS. METHODS: This cross-sectional study included consecutive patients with SLSS aged between 51 and 79 years who had symptoms in one or both the legs, with and without LBP. The participants were classified into two groups: the high group (LBP visual analogue scale [VAS] score ≥ 30 mm) and the low group (LBP VAS score < 30 mm). We performed multiple logistic regression analysis with the high and low groups as dependent variables, and a receiver operating characteristic (ROC) analysis. RESULTS: A total of 80 patients with LSS were included (35 men and 45 women; mean age 64.5 years), with 47 and 30 patients in the high and low groups, respectively. Multivariate logistic regression analysis revealed that the sagittal vertical axis (SVA; + 10 mm; odds ratio, 1.331; 95% confidence interval, 1.051 - 1.660) and pelvic incidence-lumbar lordosis (PI-LL; + 1°; odds ratio, 1.065; 95% confidence interval, 1.019-1.168) were significantly associated with LBP. A receiver operating characteristic analysis revealed cut-off values of 47.0 mm of SVA and 30.5° of PI-LL, respectively. CONCLUSION: Our results indicated that SVA and PI-LL were significant predictors for LBP in SLSS. It is suggested that these parameters should be taken into consideration when assessing LBP in patients with SLSS.

腰部脊柱管狭窄症における腰痛関連因子の解析
黄金 勲矢, 高島 弘幸, 寺島 嘉紀, 吉本 三徳, 竹林 庸雄, 山下 敏彦
Journal of Spine Research, 13, 5, 770, 777, (一社)日本脊椎脊髄病学会, May 2022
Japanese, はじめに:目的は腰部脊柱管狭窄症における腰痛と関連する因子を解析することである.対象と方法:対象は腰部脊柱管狭窄症の患者120例(男性52例,女性68例,平均年齢64.1歳)で腰痛visual analogue scale(VAS)が30mmより大きいH群,30mm以下のL群に分類した.神経障害型式,VAS(下肢痛,下肢しびれ),骨密度,すべり,脊柱・骨盤アライメント,椎間板変性,多裂筋断面積と脂肪浸潤,Modic change,椎間関節変性を解析した.結果:H群とL群の平均はそれぞれ,下肢痛VASが73.3mmと50.3mm,下肢しびれVASが76.2mmと51.2mm,腰椎前彎角(lumbar lordosis:LL)が32.6°,40.4°,sagittal vertical axis(SVA)が54.4mm,29.2mm,仙骨傾斜が27.7°,32.3°,pelvic incidence(PI)-LLが15.9°,9.6°で有意差を認めた.多重ロジスティック回帰分析でSVA(調整オッズ比:1.017,95%信頼区間:1.003～1.031,p<0.05)とPI-LL(調整オッズ比:1.058,95%信頼区間:1.012～1.152,p<0.05)が有意となった.結語:腰部脊柱管狭窄症における腰痛にSVAとPI-LLが有意に関連していた.(著者抄録)

圧縮センシング併用3D MRIにおけるCS reduction factorが空間分解能に与える影響　　　　　　　　　　　　　　　
植村 美穂, 中西 光広, 赤塚 吉紘, 今村 塁, 長濱 宏史, 沼澤 香夏子, 高島 弘幸
北海道放射線技術雑誌, 92, 32, 33, (公社)日本放射線技術学会-北海道支部, Apr. 2022, [Last author]
Japanese

呼吸同期の有無による圧縮センシング併用4D flow MRIの撮像時間および大動脈血流定量値の比較　　　　　　　　　　　　　　　
沼澤 香夏子, 中西 光広, 赤塚 吉紘, 今村 塁, 植村 美穂, 鈴木 瑞穂, 高島 弘幸
北海道放射線技術雑誌, 92, 43, 44, (公社)日本放射線技術学会-北海道支部, Apr. 2022, [Last author]
Japanese

胸骨骨折否定目的で行ったMRIで肋軟骨損傷と診断された1例　　　　　　　　　　　　　　　
赤塚 吉紘, 中西 光広, 植村 美穂, 今村 塁, 早川 耕平, 高島 弘幸
北海道放射線技術雑誌, 92, 50, 51, (公社)日本放射線技術学会-北海道支部, Apr. 2022, [Last author]
Japanese

びまん性特発性骨増殖症罹患と血管石灰化・心血管イベント発症の関連性
廣田 亮介, 吉本 三徳, 高島 弘幸, 安田 尚美, 川原田 修義, 山下 敏彦
東日本整形災害外科学会雑誌, 34, 1, 6, 12, 東日本整形災害外科学会, Mar. 2022
Japanese, びまん性特発性骨増殖症(DISH)と血管石灰化・心血管イベント発生の相互関連性について調査した.心血管イベント発生症例はDISH罹患率が高く,DISHを有する症例は冠動脈・大動脈の石灰化が強いという結果からDISHと心血管イベントには何らかの相関があることが示唆された.本疾患の病態生理・発生メカニズムを捉える際に肝要な結果である.また,本知見は未治療の心血管疾患の早期発見・対応に有用となりうる.(著者抄録)

Effect of Minimally Invasive Selective Laminectomy for Cervical Spondylotic Myelopathy on Degenerative Spondylolisthesis.
Kota Kurihara, Kousuke Iba, Atsushi Teramoto, Makoto Emori, Ryosuke Hirota, Tsutomu Oshigiri, Izaya Ogon, Noriyuki Iesato, Yoshinori Terashima, Hiroyuki Takashima, Mitsunori Yoshimoto, Tsuneo Takebayashi, Toshihiko Yamashita
Clinical spine surgery, 35, 1, E242-E247, E247, LIPPINCOTT WILLIAMS & WILKINS, 01 Feb. 2022, [International Magazine]
English, Scientific journal, STUDY DESIGN: Retrospective analysis of prospectively collected observational data. OBJECTIVE: This study aimed to evaluate the slippage, sagittal alignment, and range of motion (ROM) after selective laminectomy (SL) in patients who had cervical spondylotic myelopathy (CSM) with degenerative spondylolisthesis (DS). SUMMARY OF BACKGROUND DATA: Clinical outcomes have been reported for both decompression and fusion surgeries for DS of the lumbar spine. However, only a few reports have examined cervical spine spondylolisthesis. MATERIALS AND METHODS: This study included 178 patients who underwent SL for CSM. Those with ossification of the posterior longitudinal ligament were excluded. Slippage >2 mm was defined as spondylolisthesis, and spondylolisthesis progression was defined as an additional displacement >2 mm on a neutral radiograph. The slippage, translational motion, C2-C7 angle, local kyphosis, and ROM were examined before and ≥2 years after surgery. Radiologic parameters were evaluated according to the slip direction and the number of laminae removed. RESULTS: DS was observed in 29 patients (16.3%); 24 patients, comprising 9 and 15 in the anterolisthesis and retrolisthesis groups, respectively, were successfully followed up for more than 2 years. Preoperative and postoperative radiologic changes in slippage, translational motion, C2-C7 angle, local kyphosis, and ROM were not remarkable in either group regardless of the number of laminae removed. Revision surgery for the progression of DS and alignment deterioration was not required in any patient of either group. CONCLUSIONS: SL does not affect DS, sagittal alignment, or ROM irrespective of the slip direction and the number of laminae removed, even after >2 years after surgery. Given the preservation of the posterior elements, SL may be an effective treatment for CSM with DS. LEVEL OF EVIDENCE: Level IV.

Differential diagnosis of fibroma of tendon sheath and giant cell tumor of tendon sheath in the finger using signal intensity on T2 magnetic resonance imaging.
Makoto Emori, Hiroyuki Takashima, Kousuke Iba, Tomoko Sonoda, Takashi Oda, Tadashi Hasegawa, Toshihiko Yamashita
Acta radiologica (Stockholm, Sweden : 1987), 62, 12, 1632, 1638, SAGE PUBLICATIONS LTD, Dec. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: The differential diagnosis of fibroma of tendon sheath (FTS) and giant cell tumor of tendon sheath (GCTTS) on the basis of clinical and radiographic characteristics remains difficult. PURPOSE: To evaluate the quantitative measurement of signal intensity (SI) obtained by magnetic resonance imaging (MRI) for the differential diagnosis of FTS and GCTTS in just the finger. MATERIAL AND METHODS: We retrospectively identified patients with FTS (n = 6) and GCTTS (n = 22) of the finger who were treated at our hospitals between April 2011 and August 2019. Two researchers independently reviewed the MRIs and measured the regions of interest (ROIs) in the tumor and flexor tendon from the same image. The SI ratio obtained for the tumor and tendon ROIs was measured and compared using receiver-operating characteristic curve analyses. Sensitivity and specificity analyses were performed. RESULTS: The SI ratios (mean ± SD) of FTS and GCTTS were 1.83 ± 0.64 and 6.34 ± 3.16 for researcher 1 and 1.82 ± 0.60 and 6.10 ± 3.22 for researcher 2, respectively. The areas under the curve were 0.970 and 0.970 for researchers 1 and 2, respectively. The cut-off values of the SI ratio as determined by researchers 1 and 2 for differentiating FTS from GCTTS were 3.00 and 3.00, respectively (sensitivity = 95.5%, specificity = 100%). CONCLUSIONS: The SI ratio is useful for differentiating FTS from GCTTS independent of a combination of tumor signal and shape.

足関節外側靱帯における3D MRIシーケンスの比較
赤塚 吉紘, 寺本 篤史, 高島 弘幸, 中西 光広, 渡邉 耕太, 山下 敏彦
整形・災害外科, 64, 13, 1705, 1709, 金原出版(株), Dec. 2021
Japanese, ＜文献概要＞足関節外側靱帯損傷における三次元(3D)MRI評価は有用であるが,最適な撮像条件に関しては一定の見解が得られていない。本研究では,健常ボランティア22名22足(男性15名,女性7名)を対象に,spin echo法である3D VISTAと,gradient echo法である3D balanced FFEの撮像を行い,前距腓靱帯(ATFL)と踵腓靱帯(CFL)の画像コントラストを比較した。取得した画像のATFL,CFL,およびそれらの周囲組織である腓骨,皮下脂肪に関心領域を設定し,コントラストノイズ比を測定した。ATFLと周囲組織とのコントラストノイズ比は,3D balanced FFEより3D VISTAの方が高い値を示した。また,CFLに関しても同様の傾向を示した。足関節外側靱帯を対象に3D MRIを撮像する場合には3D VISTAを選択することが望ましい。

MRIの新しい骨イメージング
高島 弘幸, 山下 敏彦
整形･災害外科, 64, 9, 1141, 1145, 金原出版, 01 Aug. 2021, [Lead author, Corresponding author]
Japanese, ＜文献概要＞MRIは,CTに比べ軟部組織のコントラストに優れるという利点がある一方,骨を直接的に評価するには限界があった。MRIの新たな撮像法であるFRACTUREの開発によって,皮質骨や海綿骨を画像化することが可能となり,様々な部位に応用されつつある。今後,MRIの利点である良好な軟部組織のコントラストに骨の評価を組み合わせることで,さらなる有用性が期待される。

Magnetic Resonance Spectroscopic Analysis of Multifidus Muscle Lipid Contents and Association with Nociceptive Pain in Chronic Low Back Pain.
Izaya Ogon, Kouske Iba, Hiroyuki Takashima, Mitsunori Yoshimoto, Tomonori Morita, Tsutomu Oshigiri, Yoshinori Terashima, Makoto Emori, Atsushi Teramoto, Tsuneo Takebayashi, Toshihiko Yamashita
Asian spine journal, 15, 4, 441, 446, KOREAN SOC SPINE SURGERY, Aug. 2021, [International Magazine]
English, Scientific journal, STUDY DESIGN: Cross-sectional study. PURPOSE: This study aimed to analyze the differences in the lipid contents in chronic low back pain (CLBP) patients with nociceptive pain (NocP) and neuropathic pain (NeP) using magnetic resonance spectroscopy (MRS) of the multifidus muscle (Mm). OVERVIEW OF LITERATURE: Early identification of the pain characteristics with CLBP is important because specific treatment approaches are required, depending on NocP and NeP. METHODS: The participants were 50 patients with CLBP (23 men and 27 women; mean age, 63.1±17.8 years; range, 41-79 years). We compared the Visual Analog Scale (VAS) scores, intramyocellular lipids (IMCLs) and extramyocellular lipids (EMCLs) of the Mm in NocP and NeP groups, as evaluated with the Japanese NeP screening questionnaire. RESULTS: The patients were categorized into the NocP (n=32) and NeP (n=18) groups. The mean VAS score of the NocP group was 59.3±3.1 mm and that of the NeP group was 73.6±4.6 mm. The mean VAS score was significantly higher in the NeP group as compared to that in the NocP group (p<0.01). As per the analysis of covariance for the VAS score, the mean IMCL levels of the Mm in the NocP and NeP groups were 722.3 mmol/L (95% confidence interval [CI], 611.4-833.1) and 484.8 mmol/L (95% CI, 381.1-588.5), respectively. The mean IMCL level was significantly higher in the NocP group than in the NeP group (p<0.05). The mean EMCL levels of the Mm for the NocP and NeP groups were 6,022.9 mmol/L (95% CI, 4,510.6-7,535.2) and 5,558.1 mmol/L (95% CI, 4,298.3-6,817.9), respectively; however, the difference was not significant (p=0.72). CONCLUSIONS: The results indicated an association between the IMCL level of the Mm and NocP. Our results suggest that MRS of the Mm might be beneficial for the assessment of CLBP as well as appropriate targeted analgesic therapies.

Does renin-angiotensin system inhibition have impacts on muscle mass and bone mineral density in heart failure patients?
Satoshi Katano, Toshiyuki Yano, Masaki Shimizu, Katsuhiko Ohori, Hidemichi Kouzu, Masayuki Koyama, Ryohei Nagaoka, Takuya Inoue, Yuhei Takamura, Tomoyuki Ishigo, Hiroyuki Takashima, Masaki Katayose, Hirofumi Ohnishi, Tetsuji Miura
ESC heart failure, 8, 4, 2617, 2624, WILEY PERIODICALS, INC, Aug. 2021, [International Magazine]
English, Scientific journal, AIMS: Results of experimental studies have indicated the possibility of muscle and bone mass being negatively regulated by renin-angiotensin system (RAS) activation, but that possibility has not been analysed in patients with heart failure (HF). METHODS AND RESULTS: Data for HF patients who received a dual-energy X-ray absorptiometry scan in our hospital were reviewed. Propensity scores for the use of RAS inhibitors (RASIs) were calculated using a multivariate logistic regression model to minimize selection bias. One hundred sixty pairs of patients were extracted. Plasma aldosterone concentration was significantly lower in the RASIs group than in the no-RASIs group (119 [IQR 71-185] vs. 94 [IQR 60-131] pg/mL, P = 0.003), confirming RAS inhibition in the RASIs group. Skeletal muscle mass index tended to be higher in the RASIs group than in the non-RASIs group (15.6 [IQR 14.0-17.2] vs. 15.0 [IQR 13.3-16.6] pg/mL, P = 0.065). The proportion of patients with muscle wasting, defined as appendicular skeletal muscle mass indexes of <7.00 and <5.40 kg/m2 for males and females, respectively, was significantly lower in the RASIs group than in the non-RASIs group (53% vs. 64%, P = 0.041). Multivariate logistic regression analysis showed that the no use of RASIs was associated with presence of muscle wasting independently of age, presence of diabetes, renal function, and severity of HF. Bone mineral densities and proportions of patients with osteoporosis were similar in the two groups. CONCLUSIONS: Renin-angiotensin system inhibition is associated with a lower prevalence of muscle wasting in HF patients independently of established risk factors.

早期変形性膝関節症に対するT2*マッピングを用いた軟骨と半月の定量解析
今村 塁, 寺本 篤史, 神谷 智昭, 岡田 葉平, 村橋 靖崇, 高島 弘幸, 赤塚 吉紘, 渡邉 耕太, 山下 敏彦
日本整形外科学会雑誌, 95, 8, S1638, S1638, (公社)日本整形外科学会, Aug. 2021
Japanese

【痛み-慢性痛研究の最近の話題と将来展望】画像診断 多裂筋の画像診断 Magnetic resonance spectroscopyによる定量的解析
黄金 勲矢, 高島 弘幸, 山下 敏彦
医学のあゆみ, 278, 1, 38, 42, 医歯薬出版(株), Jul. 2021
Japanese, 近年、さまざまな機能的画像法が臨床応用されており、障害部位の同定のみならず痛みとの関連性についても報告されている。Magnetic resonance spectroscopy(MRS)は筋脂肪変性を筋細胞内脂肪(IMCL)と筋細胞外脂肪(EMCL)に分離して評価することが可能で、前者は有酸素代謝能に関連し、後者は代謝不活性の脂質とされる。本研究では多裂筋のIMCLの増加は腰痛の悪化、脊柱アライメント不良(腰椎前彎減少、前傾姿勢)、椎間板変性と関連が認められた。MRSを用いた多裂筋の画像解析は慢性腰痛の病態解析の一助となる可能性がある。(著者抄録)

【腰痛の発生・慢性化のメカニズム】慢性腰痛に関する定量的MRIを用いた画像的検討
黄金 勲矢, 高島 弘幸, 寺島 嘉紀, 吉本 三徳, 竹林 庸雄, 山下 敏彦
Journal of Spine Research, 12, 6, 819, 824, (一社)日本脊椎脊髄病学会, Jun. 2021
Japanese, 慢性腰痛患者における腰痛visual analogue score(VAS)と椎間板T2値,多裂筋と大腰筋の筋細胞内脂肪(intramyocellular lipids:IMCL)および筋細胞外脂肪(extramyocellular lipids:EMCL),脊柱骨盤アライメント,腰椎可動域の関連について検討した.腰痛VASはL4/5の後方線維輪のT2値と有意な負の相関(r=-0.49,p<0.01),多裂筋のIMCLと有意な正の相関(r=0.51,p<0.01),腰椎前彎角と有意な負の相関(r=-0.41,p<0.01),sagittal vertical axisと有意な正の相関(r=0.42,p<0.01)を認めた.L4/5の後方線維輪周囲の豊富な神経支配,IMCLの増加にともなう炎症,脊柱後彎による椎間板への負荷,筋内圧の上昇,筋虚血などが慢性腰痛の一因であると考えられた.(著者抄録)

Evaluation of a Polyethylene Glycol Phantom for Measuring Apparent Diffusion Coefficients Using Three 3.0 T MRI Systems
Eisuke Sato, Kei Fukuzawa, Hiroyuki Takashima, Yuya Yamatani, Yasuo Takatsu, Junichi Hata, Keigo Hikishima, Kenta Miwa
Applied Magnetic Resonance, 52, 5, 619, 631, SPRINGER WIEN, May 2021
English, Scientific journal, We aimed to examine the possibility that polyethylene glycol (PEG) phantoms can simulate apparent diffusion coefficients (ADCs) of malignant tumors and the effectiveness of PEG phantoms using three 3.0 T magnetic resonance imaging (MRI) systems. In particular, the correlations between PEG concentrations and ADC values, the validation of ADC measurement precision, and the stability and reproducibility of PEG phantom were verified. A phantom containing 0, 0.625, 1.250, 2.5, 5, 10, 20 mM PEG was assessed using three MRI systems. The endpoints comprised correlations between PEG concentrations and ADC, validation of ADC measurement precision and the stability and reproducibility of the PEG phantom. The correlation coefficients between PEG concentrations and the ADC of the three MRI systems and among the three MRI systems revealed negative (r ≈ − 1.000, P < 0.001) and positive (r ≈ 1.000, P < 0.001) correlations. The ADCmean of 2.5–20 mM PEG was significant (P < 0.05 t tests), and that at ≥ 10 mM PEG was < 1.0 × 10–3 mm2/s. The %CV ranged from 1.20 to 4.62, and repeatability was confirmed by the 90% confidence interval. The maximum values for DifferenceChange over time and DifferencePri.vs.New were 0.20 and 0.19 × 10–3 mm2/s, respectively. In this study, we found that PEG concentrations ≥ 10 mM are required to simulate the ADCs of malignant tumors (ADC < 1.0 × 10–3 mm2/s). We also showed that the ADC value is easily controlled by adjusting PEG concentrations, and can be stably measured using our PEG phantom for at least 6 months. The PEG phantom can easily and stably simulate the ADC of malignant tumors with high reproducibility.

Accumulation of Macromolecules in Idiopathic Normal Pressure Hydrocephalus.
Yukinori Akiyama, Rintaro Yokoyama, Hiroyuki Takashima, Yuka Kawata, Masayasu Arihara, Ryohei Chiba, Yusuke Kimura, Takeshi Mikami, Nobuhiro Mikuni
Neurologia medico-chirurgica, 61, 3, 211, 218, JAPAN NEUROSURGICAL SOC, 15 Mar. 2021, [Domestic magazines]
English, Scientific journal, The clearance system in the brain is not completely understood. The aim of this study was to prove the presence of the "glymphatic system" in the human brain using magnetic resonance spectroscopy (MRS).Spectral data of the brain white matter were obtained from healthy volunteers and patients with hydrocephalic dementia and used to measure intracerebral metabolites, including macromolecules (MMs) and lipids. Data were transferred from the MRS scanners to a workstation, and metabolites were quantified with the spectrogram-based eddy current method and water scaling.MM levels were significantly higher in patients with a slow gait and executive dysfunction due to normal pressure hydrocephalus (NPH) than in asymptomatic volunteers (p <0.01). In contrast, the N-acetyl aspartate (NAA) level was significantly lower in patients with executive dysfunction than in asymptomatic volunteers (p <0.01). There were no statistically significant differences in metabolites, including alanine, aspartate, creatine, γ-amino butyric acid, D-glucose, glutamine, glutamate, glycerophosphorylcholine, phosphorylcholine, lactate, myoinositol, N-acetyl-aspartyl-glutamate, scyllo-inositol, taurine, creatine methylene, and guanine, in the centrum semiovale between patients with NPH and asymptomatic volunteers.We quantitatively evaluated cerebral metabolites, particularly in the centrum semiovale, with MRS. In the brain of patients with a slow gait and executive dysfunction due to NPH, MRS revealed significantly higher MM levels and lower NAA levels compared to healthy volunteers. Therefore, it may be concluded that the patients have a dysfunctional glymphatic system in the brain.

Association between lumbar segmental mobility and intervertebral disc degeneration quantified by magnetic resonance imaging T2 mapping.
Izaya Ogon, Kousuke Iba, Hiroyuki Takashima, Yoshinori Terashima, Mitsunori Yoshimoto, Makoto Emori, Atsushi Teramoto, Tsuneo Takebayashi, Toshihiko Yamashita
North American Spine Society journal, 5, 100044, 100044, Mar. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: The relation between segmental mobility and degree of lumbar degenerative change is still unknown. This cross-sectional study aimed to elucidate the association between intervertebral disc degeneration (IVDD) and segmental mobility in chronic low back pain using magnetic resonance imaging (MRI) T2 mapping. METHODS: Subjects comprised 60 patients (29 men, 31 women; mean age, 61.8 ± 1.9 years; range, 41-79 years). T2 values of the anterior annulus fibrosus (AF), the nucleus pulposus (NP) and the posterior AF were evaluated with MRI T2 mapping. Facet joint degeneration was divided into 4 grades using MRI. We analyzed the correlation between segmental mobility and T2 values of anterior AF, NP and posterior AF using multiple linear regression analysis adjusted for age and facet joint degeneration. RESULTS: The standardized partial regression coefficient of the anterior AF, NP and posterior AF T2 values were 0.125 (p=0.72), 0.499 (p<0.01) and -0.026 (p=0.11), respectively, for the L1-2 level; 0.102 (p=0.27), 0.395 (p<0.01) and -0.094 (p=0.20), respectively, for the L2-3 level; 0.108 (p=0.38), 0.415 (p<0.01) and -0.050 (p=0.51), respectively, for the L3-4 level; 0.124 (p=0.09), 0.396 (p<0.01) and 0.025 (p=0.73), respectively, for the L4-5 level; and 0.011 (p=0.89), 0.443 (p<0.01) and 0.030 (p=0.72), respectively, for the L5-S level. There was a significantly positive correlation between segmental mobility and the T2 values of NP at L1-L2, L2-L3, L3-L4, L4-L5, and L5-S1. No significant correlations arose between segmental mobility and the T2 values of the anterior AF and the posterior AF at L1-L2, L2-L3, L3-L4, L4-L5, and L5-S1. CONCLUSION: Characterization of the relationship between NP degeneration and lumbar segmental mobility may enhance our ability to evaluate the changes seen in kinematics of functional spinal unit.

Visualization of cerebellar peduncles using diffusion tensor imaging.
Hiroshi Nagahama, Masahiko Wanibuchi, Toru Hirano, Mitsuhiro Nakanishi, Hiroyuki Takashima
Acta neurochirurgica, 163, 3, 619, 624, SPRINGER WIEN, Mar. 2021, [Last author], [International Magazine]
English, Scientific journal, The cerebellum communicates with the cerebral cortex via the superior, middle, and inferior cerebellar peduncles (CPs). To preserve the structure and function of the brainstem and cerebellum, which is compressed in various pathological conditions, it is important to delineate the spatial interrelationship of the CPs for presurgical planning and intraoperative guidance. Diffusion tensor tractography (DTT) is a technique capable of depicting the major fiber bundles in CPs. However, routine use of this technology for brainstem visualization remains challenging due to the anatomical smallness and complexity of the brainstem and susceptibility-induced image distortions. Here, we attempt to visualize CPs using high-resolution DTT in a commercial equipment for the application of this technique in normal clinical settings. DTT and fast imaging employing steady-state acquisition-cycled phases (FIESTA) of the whole brainstem were performed. We rendered the DTT fiber bundle using a region-of-interest-based fiber tracking method onto the structural image generated in FIESTA by automatic image coregistration. Fibers of the CPs were clearly visualized by DTT. The DTT-FIESTA overlaid image revealed the cross-sectional and three-dimensional anatomy of the pyramidal tract and the ascending sensory fibers, in addition to the CPs. This could indicate a geometrical relationship of these fibers in the brainstem. The CPs could be visualized clearly using DTT within clinically acceptable scanning times. This method of visualizing the exact pathway of fiber bundles and cranial nerves in the skull base helps in the planning of surgical approaches.

Optimal acceleration factor for image acquisition in turbo spin echo: diffusion-weighted imaging with compressed sensing.
Hiroyuki Takashima, Mitsuhiro Nakanishi, Rui Imamura, Yoshihiro Akatsuka, Hiroshi Nagahama, Izaya Ogon
Radiological physics and technology, 14, 1, 100, 104, SPRINGER JAPAN KK, Mar. 2021, [Lead author, Corresponding author], [Domestic magazines]
English, Scientific journal, In this study, the change in the image quality and apparent diffusion coefficient (ADC) with increase in the acceleration factor (AF) was analyzed and the most optimal AF was determined to reduce the scan time while preserving the image quality. The AF was changed from 2 to 20 in the MR acquisitions. The similarities between the accelerated and reference images were determined based on the structural similarity (SSIM) index for DWI image and coefficient of variation (%CV) for ADC. The SSIM index decreased significantly when the AF ≥ 8 compared with when the AF = 2 (p < 0.05). In the reference image, the %CV of the ADC increased significantly when the AF ≥ 10 (p < 0.01). In conclusion, a remarkable decrease in the image quality and ADC was observed when the AF was > 8. Thus, an AF < 8 would be optimal for reducing the scan time while preserving the image quality.

Associations between visceral fat chronic low back pain and central sensitization in patients with lumbar spinal stenosis.
Izaya Ogon, Atsushi Teramoto, Hiroyuki Takashima, Yoshinori Terashima, Mitsunori Yoshimoto, Makoto Emori, Kousuke Iba, Tsuneo Takebayashi, Toshihiko Yamashita
Journal of back and musculoskeletal rehabilitation, 35, 5, 1035, 1041, IOS PRESS, 16 Feb. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: Pain sensitization may be one of the mechanisms contributing to chronic low back pain (CLBP). OBJECTIVE: To evaluate the association between visceral fat, CLBP, and central sensitization (CS); describe the relationship between low back pain (LBP) intensity and CS; and identify possible correlation between visceral fat and LBP intensity. METHODS: Patients with CLBP were divided using their CS inventory (CSI) scores into low- (CSI < 40) and high-CSI (CSI ⩾ 40) subgroups. We compared computed tomography (CT) measurements and scores for association with pain according to the visual analogue scale (VAS) between the two groups. RESULTS: The low-CSI and the high-CSI groups had 47 patients (67.1%; 21 men, 26 women) and 23 patients (32.9%; 11 men and 12 women), respectively. The high-CSI group had a significantly higher mean VAS score (p< 0.01) and estimated mean visceral fat area (p< 0.05) than the low-CSI group. There was a moderate positive correlation between VAS score and visceral fat (standardised partial regression coefficient: 0.659, p< 0.01) in the high-CSI group according to multiple linear regression analysis adjusted for age and sex. CONCLUSIONS: Visceral fat is associated with CLBP, regardless of sex or age, and may be a potential therapeutic target for CLBP with CS.

Relationship Between Plantar Callosity and Foot Deformity in Hallux Valgus Using Weightbearing Computed Tomography.
Yasutaka Murahashi, Kousuke Iba, Atsushi Teramoto, Katsunori Takahashi, Yohei Okada, Tomoaki Kamiya, Hiroyuki Takashima, Kota Watanabe, Hirofumi Ohnishi, Toshihiko Yamashita
The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons, 60, 6, 1207, 1211, ELSEVIER SCIENCE INC, 2021, [International Magazine]
English, Scientific journal, Plantar callosities under lesser metatarsals are often accompanied by the hallux valgus, and the cause of callosity is thought to be associated with the foot deformity, such as the metatarsal length discrepancy, the abnormal metatarsal head height, cavus, flat foot, and rheumatoid conditions. However, it is unclear which variable is most involved in the cause of callosity in hallux valgus deformity. To clarify the factors associated with the callosity with hallux valgus deformity, we conducted multiple image assessments based on weightbearing radiography and computed tomography. A retrospective review was performed based on the collection of clinical records from all patients with hallux valgus treated from 2010 to 2019 in our institution. We measured the hallux valgus angle, intermetatarsal angles, calcaneal pitch angles, talo-first metatarsal angles, metatarsal length, metatarsal head height, first metatarsal pronation angles, and sesamoid position with weightbearing radiography and computed tomography. We analyzed the relation between callosity formation and imaging assessments using univariate and multivariate logistic regression models. Fifty feet were retrospectively evaluated, and multiple logistic analyses by the stepwise method revealed that the first metatarsal-lateral-sesamoid distance was the only radiographical variable associated with callosity formation among all the tested variables (p < .001). As the grade of the callosity became more severe, the lateral shift of the lateral sesamoid increased. The position of the sesamoid bone appears to have a critical role in the assessment and choice of treatment protocols and further research needs to be conducted on the relationship with the position of sesamoid bone to elucidate the mechanism of callus formation.

早期・初期変形性膝関節症における内側半月後節と関節軟骨のT2*値の関連
今村 塁, 高島 弘幸, 赤塚 吉紘, 寺本 篤史, 神谷 智昭, 岡田 葉平, 村橋 靖崇, 山下 敏彦, 渡邉 耕太
北海道整形災害外科学会雑誌, 63, 139th suppl, 35, 35, 北海道整形災害外科学会, 2021
Japanese

Clinical Risk Factors and Prognostic Impact of Osteoporosis in Patients With Chronic Heart Failure.
Satoshi Katano, Toshiyuki Yano, Takanori Tsukada, Hidemichi Kouzu, Suguru Honma, Takuya Inoue, Yuhei Takamura, Ryohei Nagaoka, Tomoyuki Ishigo, Ayako Watanabe, Katsuhiko Ohori, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Hiroyuki Takashima, Akiyoshi Hashimoto, Masaki Katayose, Tetsuji Miura
Circulation journal : official journal of the Japanese Circulation Society, 84, 12, 2224, 2234, JAPANESE CIRCULATION SOC, 25 Nov. 2020, [Domestic magazines]
English, Scientific journal, BACKGROUND: The clinical significance of osteoporosis in chronic heart failure (CHF) remains unclear.Methods and Results:A total of 303 CHF patients (75 years, [interquartile range (IQR) 66-82 years]; 41% female) were retrospectively examined. Bone mineral densities (BMDs) at the lumbar spine, femoral neck, and total femur were measured by using dual-energy X-ray absorptiometry (DEXA), and osteoporosis was diagnosed when the BMD at any of the 3 sites was <70% of the Young Adult Mean percentage (%YAM). The prevalence of osteoporosis in CHF patients was 40%. Patients with osteoporosis were older (79 [IQR, 74-86] vs. 72 [IQR, 62-80] years), included a large percentage of females, had slower gait speed and had a lower body mass index. Multivariate logistic regression analysis indicated that sex, BMI, gait speed, loop diuretics use and no use of direct oral anticoagulants (DOACs) were independently associated with osteoporosis. Kaplan-Meier survival curves showed that the rate of death and heart failure hospitalization was higher in patients with osteoporotic BMD at 2 or 3 sites than in patients without osteoporosis (hazard ratio 3.45, P<0.01). In multivariate Cox regression analyses, osteoporotic BMD at 2 or 3 sites was an independent predictor of adverse events after adjustment for prognostic markers. CONCLUSIONS: Loop diuretics use and no DOACs use are independently associated with osteoporosis in CHF patients. Osteoporosis is a novel predictor of worse outcome in patients with CHF.

Bioabsorbable interference screws can be used with less tunnel widening in anatomic rectangular tunnel anterior cruciate ligament reconstruction with a bone-patellar-tendon-bone graft.
Kousuke Shiwaku, Tomoyuki Suzuki, Takashi Matsumura, Hiroyuki Takashima, Hidenori Otsubo, Toshihiko Yamashita
The Knee, 27, 5, 1293, 1299, ELSEVIER, Oct. 2020, [International Magazine]
English, Scientific journal, BACKGROUND: The purpose of this study was to investigate postoperative tunnel widening after rectangular tunnel bone-patellar-tendon-bone graft anterior cruciate ligament reconstruction using newer-generation bioabsorbable interference screws. METHODS: Forty-six patients who had undergone primary rectangular tunnel bone-patellar-tendon-bone graft anterior cruciate ligament reconstruction using MILAGRO bioabsorbable interference screws (DePuy Synthes, Warsaw, IN, USA) for femoral fixation and for whom computed tomography was performed at two weeks and one year postoperatively were included in this prospective study. To assess the tunnel widening, the cross-sectional area of the femoral tunnel aperture (compared between two weeks and one year postoperatively) was assessed using computed tomography. Cyst formation, postoperative screw breakage, screw migration, and graft migration were also evaluated using computed tomography one year postoperatively. RESULTS: Mean tunnel widening was 1.9%, and the cross-sectional area of the femoral tunnel aperture was not significantly different between two weeks and one year postoperatively. Postoperative cyst formation, screw breakage, screw migration, and graft migration were not observed in any patient. CONCLUSIONS: After rectangular tunnel bone-patellar-tendon-bone graft anterior cruciate ligament reconstruction using bioabsorbable interference screws for femoral fixation, tunnel widening was not observed via computed tomography analysis at two weeks and one year postoperatively.

Is the Lipid Content of the Psoas Major Correlated with Chronic Low Back Pain and Spinopelvic Alignment? A Magnetic Resonance Spectroscopic Study.
Izaya Ogon, Hiroyuki Takashima, Tomonori Morita, Tsutomu Oshigiri, Yoshinori Terashima, Mitsunori Yoshimoto, Makoto Emori, Atsushi Teramoto, Tsuneo Takebayashi, Toshihiko Yamashita
Asian spine journal, 14, 4, 430, 437, KOREAN SOC SPINE SURGERY, Aug. 2020, [International Magazine]
English, Scientific journal, STUDY DESIGN: Cross-sectional observational study. PURPOSE: This study aimed to analyze any potential associations of extramyocellular lipid (EMCL) and intramyocellular lipid (IMCL) contents with (1) the intensity of low back pain (LBP); (2) age, cross-sectional area (CSA), and fatty infiltration (FI) of the psoas major; and (3) spinopelvic parameters. OVERVIEW OF LITERATURE: The psoas major has clinically relevant function; however, the association of this muscle with chronic LBP is controversial. Magnetic resonance spectroscopy enables a detailed analysis of the composition of muscular fat tissues such as its EMCL and IMCL contents. METHODS: The study population comprised 40 patients (19 males, 21 females; mean age, 61.7±2.4 years). Possible correlations of LBP Visual Analog Scale (VAS) scores, age, CSA, FI, and spinopelvic parameters with EMCL and IMCL contents of the psoas major were assessed. RESULTS: No association was identified between the EMCL and IMCL contents and LBP VAS scores (r=0.05, p=0.79 and r=0.06, p=0.75, respectively). The EMCL content correlated with age (r=0.47, p<0.01), body mass index (BMI) (r=0.44, p<0.01), CSA (r=-0.59, p< 0.01), and FI (r=0.49, p<0.01). EMCL content showed a significant negative correlation with sacral slope (SS) (r=-0.43, p<0.05) and positive correlation with pelvic tilt (PT) (r=0.56, p<0.01). CONCLUSIONS: EMCL content correlated with age, BMI, CSA, and FI of the psoas major, while IMCL content had no correlation. This study found correlations between SS and PT and EMCL content of the psoas major, but no correlations were found between spinopelvic parameters and IMCL content of the psoas major.

Lumbar disc degeneration assessment using T2* relaxation time with ultra-short TE.
Hiroyuki Takashima, Mitsunori Yoshimoto, Izaya Ogon, Yoshinori Terashima, Rui Imamura, Yoshihiro Akatsuka, Noriyuki Iesato, Tsutomu Oshigiri, Tomonori Morita, Tsuneo Takebayashi, Makoto Emori, Atsushi Teramoto, Toshihiko Yamashita
Magnetic resonance imaging, 73, 11, 14, ELSEVIER SCIENCE INC, 14 Jul. 2020, [Lead author, Corresponding author], [International Magazine]
English, Scientific journal

MRI拡散強調像における前臨床研究のための画像評価用ファントムの開発　　　　　　　　　　　　　　　
高島 弘幸
医療の広場, 60, 7, 8, 10, (公財)政策医療振興財団, Jul. 2020, [Lead author, Last author, Corresponding author]
Japanese

Efficacy of non-rigid registration technique for misregistration in 3D-CTA fusion imaging.
Yoshiya Ohashi, Hiroyuki Takashima, Goh Ohmori, Kohei Harada, Ayaka Chiba, Kanako Numasawa, Tatsuya Imai, Shun Hayasaka, Aya Itoh
La Radiologia medica, 125, 7, 618, 624, SPRINGER-VERLAG ITALIA SRL, Jul. 2020, [Corresponding author], [International Magazine]
English, Scientific journal, PURPOSE: To assess whether fusion 3D-CTA images can be corrected using non-rigid registration (NRR) for gastroenterology imaging. METHODS: This study included 55 patients before gastroenterology surgery who underwent preoperative 3D-CTA prior to gastroenterological surgery. We recorded the coordinate of measurement points on the arterial vessels (X, Y, and Z) in each portal phase, original image of the arterial phase, and arterial phase with NRR. The distance of misregistration between the two points was calculated with the coordinate of the original image with NRR and that of the portal phase as true value. RESULTS: The distance of misregistration between the two points in the original arterial and portal phase images was significantly higher than that in the arterial phase image with NRR on all directions (p < 0.01). CONCLUSIONS: This study showed that NRR may correct misregistration on fusion 3D-CTA imaging. Hence, it can visualize correctly the anatomy of the vessel.

慢性腰痛患者における腰痛の改善に伴う多裂筋の筋細胞内脂肪の変化
高島 弘幸, 黄金 勲矢, 竹林 庸雄, 押切 勉, 森田 智慶, 吉本 三徳, 寺島 嘉紀, 山下 敏彦
Journal of Spine Research, 11, 6, 897, 901, (一社)日本脊椎脊髄病学会, Jun. 2020, [Lead author, Corresponding author]
Japanese, 慢性腰痛患者では,多裂筋の筋細胞内脂肪(intramyocellular lipids:IMCL)が上昇していることが報告されている.本研究では,慢性腰痛患者における多裂筋のIMCLが腰痛の経過とともにどのように変化するかを縦断的に解析した.腰痛VASの改善率とIMCLの変化率の間には,正の相関(r=0.818,p<0.001)が認められ,腰痛の改善とともにIMCLが低下する傾向であった.多裂筋のIMCLは,慢性腰痛と深い関連があることが示唆された.(著者抄録)

圧縮センシングMRIは心筋T1mappingの空間分解能向上に貢献できるか　　　　　　　　　　　　　　　
中西 光広, 赤塚 吉紘, 今村 塁, 長濱 宏史, 高島 弘幸
北海道放射線技術雑誌, 88, 48, 49, (公社)日本放射線技術学会-北海道支部, Apr. 2020, [Last author]
Japanese

脳の圧縮センシングMRI 三次元等方性ボクセルスピンエコーの撮像時間は半減する　　　　　　　　　　　　　　　
長濱 宏史, 今村 塁, 赤塚 吉紘, 中西 光広, 高島 弘幸
北海道放射線技術雑誌, 88, 10, 11, (公社)日本放射線技術学会-北海道支部, Apr. 2020, [Last author]
Japanese

圧縮センシングMRIによる高倍速化が3D-TSE画像の解像度に与える影響　　　　　　　　　　　　　　　
今村 塁, 高島 弘幸, 中西 光広, 長濱 宏史, 赤塚 吉紘
北海道放射線技術雑誌, 88, 46, 47, (公社)日本放射線技術学会-北海道支部, Apr. 2020
Japanese

拡散強調像における圧縮センシングの併用はどこまで許容できるか　　　　　　　　　　　　　　　
高島 弘幸, 中西 光広, 長濱 宏史, 今村 塁, 赤塚 吉紘
北海道放射線技術雑誌, 88, 58, 59, (公社)日本放射線技術学会-北海道支部, Apr. 2020, [Lead author, Corresponding author]
Japanese

APT-CESTにおける卵白粉を用いたpHイメージングの検討　　　　　　　　　　　　　　　
赤塚 吉紘, 高島 弘幸, 今村 塁, 長濱 宏史, 中西 光広
北海道放射線技術雑誌, 88, 60, 61, (公社)日本放射線技術学会-北海道支部, Apr. 2020
Japanese

Relevance between Schmorl's Node and Lumbar Intervertebral Disc Degeneration Quantified with Magnetic Resonance Imaging T2 Mapping in Chronic Low Back Pain.
Izaya Ogon, Hiroyuki Takashima, Tomonori Morita, Tsutomu Oshigiri, Yoshinori Terashima, Mitsunori Yoshimoto, Ryunosuke Fukushi, Shutaro Fujimoto, Makoto Emori, Atsushi Teramoto, Tsuneo Takebayashi, Toshihiko Yamashita
Asian spine journal, 14, 5, 621, 628, KOREAN SOC SPINE SURGERY, 30 Mar. 2020, [International Magazine]
English, Scientific journal, Study Design: Cross-sectional study. Purpose: The purpose of this study was to elucidate the relevance among Schmorl's node (SN), chronic low back pain (CLBP), and intervertebral disc degeneration (IVDD) with the use of magnetic resonance imaging T2 mapping. Overview of Literature: SN may be combined with CLBP and/or IVDD; however, their relationship has not been determined to date. Methods: A total of 105 subjects were included (48 men and 57 women; mean age, 63.2±2.7 years; range, 22-84 years). We analyzed five functional spinal unit levels (L1-S1) and evaluated the T2 values of the anterior annulus fibrosus (AF), nucleus pulposus, and posterior AF. We compared the low back pain (LBP) Visual Analog Scale (VAS) scores and the T2 values in each decade with or without SN. Results: There were no remarkable differences in SN prevalence rate regarding age decade or gender. SNs were more prevalent in the upper 2 levels (70.3%). LBP VAS scores with and without SN were 64.7±4.3 mm and 61.9±2.8 mm, respectively, with no significant differences between the groups (p =0.62). The T2 values of anterior AF with SN were significantly lower than those without SN in patients in their 50s, 60s, 70s, and 80s (p <0.01). Conclusions: SN presence is not itself a risk factor for CLBP; however, it indicates IVDD of the anterior AF in subjects with SN who are ≥50 years old.

MR Spectroscopyを用いた尾部懸垂ラットにおける骨格筋脂肪の解析　　　　　　　　　　　　　　　
高島 弘幸, 黄金 勲矢, 寺島 嘉紀, 射場 浩介, 長濱 宏史, 山下 敏彦
日本放射線技術学会総会学術大会予稿集, 76回, 253, 253, (公社)日本放射線技術学会, Mar. 2020, [Lead author, Corresponding author]
Japanese

Imaging diagnosis for intervertebral disc.
Izaya Ogon, Tsuneo Takebayashi, Hiroyuki Takashima, Tomonori Morita, Yoshinori Terashima, Mitsunori Yoshimoto, Toshihiko Yamashita
JOR spine, 3, 1, e1066, WILEY, Mar. 2020, [International Magazine]
English, Scientific journal, Various functional magnetic resonance imaging (MRI) techniques have been investigated in recent years and are being used in clinical practice for the patients with low back pain (LBP). MRI is an important modality for diagnosing intervertebral disc (IVD) degeneration. In recent years, there have been several reported attempts to use MRI T2 mapping and MRI T1ρ mapping to quantify lumbar disc degeneration. MRI T2 mapping involves digitizing water content, proteoglycan content, and collagen sequence breakdown as relaxation times (T2 values) at each site. These digitized values are used to create a map, that is, then used to quantitatively evaluate the metabolite concentrations within IVD tissues. MRI T2 mapping utilizes the T2 relaxation time to quantify moisture content and the collagen sequence breakdown. MRI T1ρ mapping digitizes water molecule dispersion within the cartilaginous matrix to evaluate the degree of cartilaginous degeneration. Magnetic resonance spectroscopy is a less-invasive diagnostic test that provides biochemical information. Adequate analysis of the IVD has not yet been performed, although there are indications of a relationship between the adipose content of the multifidus muscle in the low back and LBP. The ultra short TE technique has been recently used to investigate lumbar cartilaginous endplates. Unlike diagnosis based on contrast-enhanced images of the IVD, which depends on the recurrence of pain that is determined subjectively, MRI-based diagnosis is less-invasive and based on objective imaging findings. It is therefore expected to play a key role in the diagnostic imaging of IVD conditions in the future.

足部・足関節の画像解析-画像解析による病態の解明- 3D MRIによる足関節外側靱帯の評価　　　　　　　　　　　　　　　
寺本 篤史, 赤塚 吉紘, 今村 塁, 高島 弘幸, 神谷 智昭, 渡邉 耕太, 山下 敏彦
日本整形外科学会雑誌, 94, 2, S45, S45, (公社)日本整形外科学会, Mar. 2020
Japanese

TKA術前下腿筋量は術後DVT発生に関連するか　　　　　　　　　　　　　　　
赤塚 吉紘, 寺本 篤史, 高島 弘幸, 岡田 葉平, 神谷 智昭, 渡邉 耕太, 山下 敏彦
日本整形外科学会雑誌, 94, 3, S766, S766, (公社)日本整形外科学会, Mar. 2020
Japanese

Denosumab prevents periprosthetic bone mineral density loss in the tibial metaphysis in total knee arthroplasty.
Yasutaka Murahashi, Atsushi Teramoto, Shunsuke Jimbo, Yohei Okada, Tomoaki Kamiya, Rui Imamura, Hiroyuki Takashima, Kota Watanabe, Satoshi Nagoya, Toshihiko Yamashita
The Knee, 27, 2, 580, 586, ELSEVIER, Mar. 2020, [International Magazine]
English, Scientific journal, BACKGROUND: Periprosthetic bone quality is one of the most important factors preventing early prosthesis migration and long-term failure. Although denosumab, which binds to the receptor activator of nuclear factor kappa-B ligand (RANKL), has been linked with periprosthetic bone mineral density (BMD), the effectiveness of denosumab against bone loss remains unclear. We hypothesized that denosumab treatment after total knee arthroplasty (TKA) could prevent periprosthetic bone resorption. METHODS: In this prospective cohort study, 28 patients with primary knee osteoarthritis were divided into two groups: denosumab (denosumab and vitamin D) and control (vitamin D only) groups. All patients underwent TKA with the same implant model and received medication after surgery. We used dual-energy X-ray absorptiometry to measure periprosthetic BMD after TKA. RESULTS: In the control group, the BMD of the proximal medial tibia decreased drastically at 12 months after TKA (-19.7%). Denosumab treatment significantly preserved this BMD loss (0.7%). The linear regression analysis revealed that denosumab intervention had the highest significantly positive relationship with BMD. CONCLUSIONS: Our results indicate that denosumab treatment significantly reduces periprosthetic BMD loss, even at the early stages after TKA. This therapeutic strategy may facilitate early stable fixation of the prosthesis which, in turn, may help to prevent early implant migration and reduce the need for revision surgery.

【腰痛診療perspective】腰痛の新しい画像診断の取り組み MR spectroscopyで評価した多裂筋脂肪変性と非特異的腰痛の関連
黄金 勲矢, 高島 弘幸, 山下 敏彦
Pharma Medica, 38, 1, 49, 53, (株)メディカルレビュー社, Jan. 2020
Japanese

Association between Spinopelvic Alignment and Lumbar Intervertebral Disc Degeneration Quantified with Magnetic Resonance Imaging T2 Mapping in Patients with Chronic Low Back Pain.
Izaya Ogon, Hiroyuki Takashima, Tomonori Morita, Tsutomu Oshigiri, Yoshinori Terashima, Mitsunori Yoshimoto, Tsuneo Takebayashi, Toshihiko Yamashita
Spine surgery and related research, 4, 2, 135, 141, JAPANESE SOC SPINE SURGERY & RELATED RESEARCH, 2020, [Domestic magazines]
English, Scientific journal, INTRODUCTION: Although intervertebral disc degeneration (IVDD) and spinopelvic malalignment are likely key structural features of spinal degeneration and chronic low back pain (CLBP), the correlation analysis has not been fully conducted. This cross-sectional quantitative magnetic resonance imaging (MRI) T2 mapping study aimed to elucidate the association between IVDD and spinopelvic alignment in CLBP patients. METHODS: The subjects included 45 CLBP patients (19 men and 26 women; mean age, 63.8 ± 2.0 years; range, 41-79 years). The T2 values of the anterior annulus fibrosus (AF), the nucleus pulposus (NP), and the posterior AF were evaluated using MRI T2 mapping. We compared the possible correlations of spinopelvic parameters with T2 values of anterior AF, NP, and posterior AF using Pearson's correlation coefficient analysis. T2 values in these regions were classified into upper (L1-L2 and L2-L3), middle (L3-L4), and lower (L4-L5 and L5-S1) disc levels, and we analyzed the correlations with spinopelvic parameters. RESULTS: There were significant correlations of the anterior AF T2 values with lumbar lordosis (r = 0.51, p < 0.01), sacral slope (r = 0.43, p < 0.01), sagittal vertical axis (r = -0.40, p < 0.01), and pelvic tilt (r = -0.33, p < 0.01). In all lumbar levels, T2 values of anterior AF had significantly positive correlation with LL and significantly negative correlation with SVA. In lower disc level, T2 values of anterior AF had significantly positive correlation with SS and significantly negative correlation with PT. T2 values of NP and posterior AF had no significant correlations with spinopelvic parameters in all lumbar disc levels. CONCLUSIONS: In summary, this study indicated that the anterior AF degeneration is associated with hypolordosis of the lumbar spine, anterior translation of the body trunk, and posterior inclination of the pelvis in CLBP. Anterior AF degeneration in all lumbar disc levels was associated with hypolordosis of the lumbar spine and anterior translation of the body trunk. Anterior AF degeneration in lower disc level was associated with posterior inclination of the pelvis.

[Knowledge Obtained from Process of Research-Does JSRT Really Aim for Society of Researcher?].
Hiroyuki Takashima
Nihon Hoshasen Gijutsu Gakkai zasshi, 76, 5, I, 2020, [Lead author], [Domestic magazines]
Japanese, Scientific journal

TKA術前下腿筋量は術後DVT発生に関連するか
赤塚 吉紘, 高島 弘幸, 寺本 篤史, 岡田 葉平, 神谷 智昭, 山下 敏彦, 渡邉 耕太
北海道整形災害外科学会雑誌, 62, 138th suppl, 76, 76, 北海道整形災害外科学会, 2020
Japanese

退行性疾患における椎間板変性と多裂筋断面積は相関する
藤田 直輝, 三木 貴弘, 渡邊 勇太, 高島 弘幸, 竹林 庸雄, 小熊 大士, 阿部 恭久, 鈴木 智之, 大西 史師, 黒田 未来, 山崎 生久男, 山村 恵
北海道整形災害外科学会雑誌, 62, 138th suppl, 13, 13, 北海道整形災害外科学会, 2020
Japanese

Associations between Paraspinal Muscle Morphology, Disc Degeneration, and Clinical Features in Patients with Lumbar Spinal Stenosis.
Takahiro Miki, Fujita Naoki, Hiroyuki Takashima, Tsuneo Takebayashi
Progress in rehabilitation medicine, 5, 20200015, 20200015, 2020, [Domestic magazines]
English, Scientific journal, Objective: The purpose of this study was to examine the relationships between intervertebral disc degeneration in the lumbar spine, paraspinal muscle morphology, and clinical features in patients with lumbar spinal stenosis (LSS). Methods: A total of 52 patients with LSS participated in this study. Magnetic resonance imaging was used to assess intervertebral disc degeneration at L4/5 and to measure the standardized cross-sectional areas (SCSAs) of the multifidus and erector spinae muscles. The intensity of low back pain (LBP) and lower limb pain, the level of disability, and the quality of life (QoL) were evaluated using patient-reported outcome measures. The associations between the image findings and clinical features, including the disability score, the pain score for low back pain, and the QoL score, were calculated using Spearman's rank correlation coefficient. Results: No associations were found between disc degeneration and clinical features. However, disc degeneration and the SCSA of the multifidus muscle (r=-0.38, P <0.01) and of the erector spinae muscle (r=-0.29, P=0.04) were significantly associated. Analysis of the associations between muscle morphology and clinical features found that the SCSA of the multifidus muscle was associated with LBP (r=0.31, P=0.03). Conclusions: These results suggest that there is some correlation between atrophy of the multifidus and pain intensity. Consequently, focusing on the CSA of the multifidus muscle may help to clarify the causes of LBP in patients with LSS. However, because of the cross-sectional nature of this study, causal relationships could not be determined and further research is needed.

3D MRI evaluation of morphological characteristics of lateral ankle ligaments in injured patients and uninjured controls.
Atsushi Teramoto, Yoshihiro Akatsuka, Hiroyuki Takashima, Hiroaki Shoji, Yuzuru Sakakibara, Kota Watanabe, Toshihiko Yamashita
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25, 1, 183, 187, ELSEVIER, Jan. 2020, [Domestic magazines]
English, Scientific journal, BACKGROUND: With ultrasonography or 2D magnetic resonance imaging (MRI) of the lateral ankle ligament, it is particularly difficult to show the entire calcaneofibular ligament (CFL). The purpose of this study was to evaluate the morphological characteristics of the lateral ankle ligaments in injured patients and uninjured controls using 3D MRI. METHODS: A total of 64 ankles of 59 healthy volunteers and lateral ligament injury patients (mean age of 32.4 years) were examined. The 64 ankles included a healthy group of 11 ankles, an acute injury group of 12 ankles that underwent MRI a month after injury, and a chronic injury group of 41 ankles that underwent MRI more than 3 months after injury. Using a 3.0-T MRI system, imaging was done with fast imaging employing steady-state acquisition cycled phases. Oblique sagittal images that most clearly depicted the entire anterior talofibular ligament (ATFL) and CFL were prepared manually and evaluated using a workstation. RESULTS: In the healthy group, both the ATFL and CFL were clearly and entirely visualized. The mean width in the central portion was 4.0 ± 1.0 mm in the ATFL and 4.8 ± 0.6 mm in the CFL. 3D MRI in the acute injury group showed findings of diffuse swelling with hyperintensity in the ATFL of all patients. The CFL in 7 of 12 ankles showed findings of diffuse swelling with hyperintensity. In the chronic injury group, morphological abnormalities of the ATFL were seen in 19 of 41 ankles. The ligament signal disappeared in 2 ankles, thinned in 4 ankles, and showed swelling in 13 ankles. Morphological abnormalities of the CFL were seen in 17 of 41 ankles. The ligament signal disappeared in 1 ankle, thinned in 2 ankles, and showed swelling in 14 ankles. CONCLUSION: 3D MRI may be a useful modality to visualize both the ATFL and the CFL.

Do We Have Adequate Flexion-extension Radiographs for Evaluating Instability in Patients With Lumbar Spondylolisthesis?
Tomonori Morita, Mitsunori Yoshimoto, Yoshinori Terashima, Katsumasa Tanimoto, Noriyuki Iesato, Izaya Ogon, Tsutomu Oshigiri, Atsushi Teramoto, Makoto Emori, Hiroyuki Takashima, Ryosuke Hirota, Shutaro Fujimoto, Toshihiko Yamashita
Spine, 45, 1, 48, 54, LIPPINCOTT WILLIAMS & WILKINS, 01 Jan. 2020, [International Magazine]
English, Scientific journal, STUDY DESIGN: A retrospective cohort study of consecutive patients. OBJECTIVE: To investigate whether adequate flexion-extension was acquired in standard functional radiographs in lumbar spondylolisthesis. SUMMARY OF BACKGROUND DATA: In lumbar spondylolisthesis, flexion-extension radiographs taken in the standing position are most commonly used to evaluate spinal instability. However, these functional radiographs occasionally depend on the patient's effort and cooperation, they can provide different results. METHODS: This study included 92 consecutive patients diagnosed with L4-5 degenerative lumbar spondylolisthesis. We analyzed the flexion-extension radiographs taken with the patient being led by the hand (LH) and those taken without LH (NLH). Sagittal translation (ST), segmental angulation (SA), posterior opening (PO), and lumbar lordosis (LL) were measured on functional radiographs taken in both tests. Then, ST, SA, PO, detection rate of instability, and LL observed in LH were compared with those observed in NLH. Furthermore, the correlation of the difference was evaluated between ST, lumbar angulation, and LL. RESULTS: A relative value of ST was 9.5% ± 4.3% in LH and 5.6% ± 3.3% in NLH, which differed significantly (P < 0.001). SA and PO were also significantly greater in LH than in NLH. The detection rate of instability was 71.7% in LH and 30.4% in NLH (P < 0.001). LL measurement on flexion showed 17.6° ± 13.5° in LH and 28.2° ± 12.2° in NLH, which differed significantly (P < 0.001). However, no significant difference was found in LL on extension between LH and NLH. There was a moderate correlation between the difference of ST, SA, PO, and LL on flexion. CONCLUSION: Flexion with physical assistance was useful for the detection of abnormal lumbar mobility. Taking radiation exposure into consideration, physical assistance such as using a table in front of a patient could lead the similar evaluation of the segmental instability. LEVEL OF EVIDENCE: 2.

Glossopharyngeal and Hypoglossal Nerve Paralysis Secondary to Prevertebral Phlegmon.
Ryunosuke Fukushi, Izaya Ogon, Yoshinori Terashima, Hiroyuki Takashima, Tsutomu Oshigiri, Noriyuki Iesato, Mitsunori Yoshimoto, Makoto Emori, Atsushi Teramoto, Toshihiko Yamashita
Case reports in orthopedics, 2020, 3795035, 3795035, 2020, [International Magazine]
English, A 50-year-old man presented to the clinic with severe neck pain, fever, and difficulty breathing and was subsequently admitted to the local orthopedics department with possible retropharyngeal abscess and pyogenic spondylitis. Antibiotic therapy was initiated; however, due to poor oxygenation, he was referred and transferred to our department and admitted. Magnetic resonance imaging showed signal changes at the left C1/2 lateral atlantoaxial joint, posterior pharynx, longus colli muscle, carotid space, and medial deep cervical region, predominantly on the left side. In addition, despite lymph node enlargement from the posterior pharynx to the deep cervical region, there was no abscess formation. There were no signs of a space-occupying lesion or signal changes in the jugular foramen. One day postadmission, the patient's temperature had risen to 39.1°C and his SpO2 had fallen. His neck pain had also worsened, and emergency surgery was decided. Preoperatively, we suspected retropharyngeal abscess and pyogenic spondylitis. On day 13 postadmission, the patient exhibited dysphagia, deviated tongue protrusion, and the curtain sign. Glossopharyngeal and hypoglossal nerve paralysis were diagnosed. The patient's swallowing functions recovered and he was discharged on day 36. We experienced a case of glossopharyngeal and hypoglossal nerve paralysis secondary to pyogenic cervical facet joint arthritis.

腰部脊柱管狭窄症における椎間板変性および脊柱筋群断面積と疼痛、機能障害、QOLとの関連の検討
藤田 直輝, 三木 貴弘, 高島 弘幸, 竹林 庸雄
Journal of Musculoskeletal Pain Research, 11, 4, S59, S59, (一社)日本運動器疼痛学会, Nov. 2019, [Peer-reviewed]
Japanese

新しい医療技術 Dual energy CT
高島 弘幸, 小倉 圭史, 山下 敏彦
整形･災害外科, 62, 11, 1399, 1402, 金原出版, 01 Oct. 2019, [Lead author, Corresponding author]
Japanese, ＜文献概要＞Dual energy CT(DECT)は,異なる2つのエネルギーを用いて画像データを取得する手法である。整形外科領域では,特に金属アーチファクトの低減に関する有用性が知られている。まだ発展途上の分野でもあり,限られた新しい装置でなければ施行不可能な技術ではあるが,今後も様々な側面から研究が行われ,その有用性が確立されることを期待する。

足関節外側靱帯におけるMRI 3Dシーケンスの比較　　　　　　　　　　　　　　　
赤塚 吉紘, 寺本 篤史, 高島 弘幸, 今村 塁, 中西 光広, 神谷 智昭, 渡邉 耕太, 山下 敏彦
日本整形外科学会雑誌, 93, 8, S1734, S1734, (公社)日本整形外科学会, Sep. 2019
Japanese

造影剤の到達遅延症例におけるBT法のトリガーCT値の検討　　　　　　　　　　　　　　　
大橋 芳也, 原田 耕平, 千葉 彩佳, 沼澤 香夏子, 今井 達也, 早坂 駿, 高島 弘幸
日本放射線技術学会雑誌, 75, 9, 1076, 1076, (公社)日本放射線技術学会, Sep. 2019, [Peer-reviewed], [Last author]
Japanese

Magnetic resonance spectroscopyを用いた多裂筋の画像診断
黄金 勲矢, 竹林 庸雄, 高島 弘幸, 森田 智慶, 寺島 嘉紀, 吉本 三徳, 山下 敏彦
北海道整形災害外科学会雑誌, 61, 1, 19, 22, 北海道整形災害外科学会, Aug. 2019
Japanese, 近年、様々な機能的画像法の研究が進み臨床応用されており、障害部位を同定するのみならず痛みとの関連についても報告されている。Magnetic resonance spectroscopy(MRS)は筋脂肪変性を筋細胞内脂肪と筋細胞外脂肪に分離して評価することが可能で、前者は有酸素代謝に関連し、後者は代謝不活性の脂質である。多裂筋の筋細胞外脂肪の増加は腰痛の悪化および脊柱アライメント不良(腰椎前彎減少、前傾姿勢)と関連があった。MRSを用いた筋肉の画像解析は慢性腰痛診断の一助となる可能性がある。(著者抄録)

Multifidus Muscles Lipid Content Is Associated with Intervertebral Disc Degeneration: A Quantitative Magnetic Resonance Imaging Study.
Izaya Ogon, Tsuneo Takebayashi, Hiroyuki Takashima, Tomonori Morita, Tsutomu Oshigiri, Yoshinori Terashima, Mitsunori Yoshimoto, Toshihiko Yamashita
Asian spine journal, 13, 4, 601, 607, KOREAN SOC SPINE SURGERY, Aug. 2019, [International Magazine]
English, Scientific journal, STUDY DESIGN: Cross-sectional study. PURPOSE: To determine the association between fatty degeneration of the multifidus muscle (Mm) and intervertebral disc degeneration (IVDD) using quantitative magnetic resonance imaging (MRI). OVERVIEW OF LITERATURE: Few studies have reported on quantitative MRI analysis of the relation between the Mm and IVDD. METHODS: The subjects with chronic low back pain comprised 45 patients (19 males, 26 females; mean age, 63.8±2.0 years; range, 41-79 years). We analyzed the intramyocellular lipids (IMCL) and extramyocellular lipids (EMCL) of the Mm using magnetic resonance spectroscopy. The T2 values of the anterior annulus fibrosus (AF), nucleus pulposus (NP), and posterior AF were evaluated using MRI T2 mapping. We compared the possible correlations of IMCL and EMCL of the Mm with the T2 values of anterior AF, NP, and posterior AF. RESULTS: There was a significant negative correlation between IMCL and T2 values of the anterior AF (r=-0.65, p<0.01). There were no significant correlations between the IMCL and T2 values of NP (r=-0.16, p=0.30) and posterior AF (r=0.07, p=0.62). There were no significant correlations between the EMCL and T2 values of the anterior AF (r=-0.11, p=0.46), NP (r=0.15, p=0.32), and posterior AF (r=0.07, p=0.66). After adjustment for age and sex using multiple linear regression analysis, there was a significant negative correlation between the IMCL and T2 values of anterior AF (standardized partial regression coefficient=-0.65, p<0.01). CONCLUSIONS: The results indicated that IMCL of the Mm might be accompanied with anterior AF degeneration. Therapeutic exercises using IMCL of the Mm as evaluation index might have the potential to identify novel targets for the treatment and prevention of IVDD.

Optimizing T1rho and T2 Values for Intervertebral Discs Obtained from the Combined T1rho and T2 Sequence
Imamura Rui, Takashima Hiroyuki, Nakanishi Mitsuhiro, Akatsuka Yoshihiro, Nagahama Hiroshi, Okuaki Tomoyuki, Yoneyama Masami, Hatakenaka Masamitsu
APPLIED MAGNETIC RESONANCE, 50, 8, 959, 966, SPRINGER WIEN, Aug. 2019, [Peer-reviewed]
English, Scientific journal, To investigate the effect of the number of spin-lock (SL) and T2 preparation pulse using T1rho and T2 values obtained from the combined T1rho and T2 sequence. We included 30 patients who underwent magnetic resonance imagingof the lumbar spine because of low back pain and leg numbness, tingling, and pain. We used 3D turbo-field echo and the adiabatic pulse as SL pulse for T1rho mapping and the block pulse as T2 preparation pulse for T2 mapping of the combined T1rho and T2 sequence. The preparation time of T1rho and T2 was set at 0, 20, 40, 60, and 80ms. We defined the T1rho and T2 values calculated from all SL and T2 preparation pulses as Dfull and decreased several number of SL and T2 preparation pulses from Dfull as other groups (D1, D2, and D3). We used the Bland-Altman analyses to estimate the systematic and proportional bias between Dfull and other groups. The 95% CI of the mean difference included zero in all groups. Therefore, systematic bias was not detected. The regression coefficients with D3 of the T1rho and T2 value were -0.34 and -0.23, respectively (p<0.01). We detected the proportional bias in the T1rho and T2 values in only D3 (0 and 80ms). An investigation of the T1rho and T2 values of IVDs using the combined T1rho and T2 sequence suggested that the accuracy of these values decreased with suitably adjusted three preparation pulses, facilitating the assessment of both T1rho and T2 values at approximately 10min.

3D MRI斜位断面による遠位脛腓靱帯結合の描出能　　　　　　　　　　　　　　　
寺本 篤史, 赤塚 吉紘, 小路 弘晃, 高島 弘幸, 神谷 智昭, 渡邉 耕太, 山下 敏彦
日本足の外科学会雑誌, 40, Suppl., S309, S309, (一社)日本足の外科学会, Jul. 2019
Japanese

【腰痛の真理追求と明るい未来へ】MRI T2*を用いた高度変性椎間板の定量的評価と腰痛の関連性
高島 弘幸, 吉本 三徳, 竹林 庸雄, 家里 典幸, 今村 塁, 赤塚 吉紘, 寺島 嘉紀, 谷本 勝正, 黄金 勲矢, 山下 敏彦
Journal of Spine Research, 10, 6, 944, 947, (一社)日本脊椎脊髄病学会, Jun. 2019, [Lead author, Corresponding author]
Japanese, T2値が短い組織を評価可能なultra-short TE(UTE)を用いて、変性椎間板のT2*値を計測し、腰痛との関連について解析した。T2*値は、椎間板変性の進行に伴い、有意に低下し、L4/5およびL5/SのT2*値と腰痛VASに負の相関が認められた。椎間板のT2*値の解析は、高度の変性椎間板の判別も可能であり、椎間板性腰痛の解析に有用である可能性が示唆された。(著者抄録)

Analysis of Neuropathic Pain Using Magnetic Resonance Imaging T2 Mapping of Intervertebral Disc in Chronic Low Back Pain.
Izaya Ogon, Tsuneo Takebayashi, Hiroyuki Takashima, Tomonori Morita, Noriyuki Iesato, Katsumasa Tanimoto, Yoshinori Terashima, Mitsunori Yoshimoto, Toshihiko Yamashita
Asian spine journal, 13, 3, 403, 409, KOREAN SOC SPINE SURGERY, Jun. 2019, [International Magazine]
English, Scientific journal, STUDY DESIGN: Cross sectional study. PURPOSE: The study aimed to analyze mechanisms underlying chronic low back pain (CLBP) using magnetic resonance imaging (MRI) T2 mapping of the intervertebral disc (IVD). OVERVIEW OF LITERATURE: MRI T2 mapping utilizes the T2 values for quantifying moisture content and collagen sequence breakdown. We previously used MRI T2 mapping for quantifying the extent of IVD degeneration (IVDD) and showed a correlation between the degeneration of the posterior annulus fibrosus (AF) and CLBP. METHODS: We enrolled 40 patients with CLBP (17 males, 23 females; mean age, 50.8±1.6 years; range, 22-60 years). IVDs were categorized as the anterior AF, nucleus pulposus (NP), and posterior AF, and T2 value for each disc was measured. T2 values, assessed using the Japanese neuropathic pain (NeP) screening questionnaire, of the NeP and nociceptive pain (NocP) groups were compared. RESULTS: T2 values of the NocP and NeP groups were 64.7±5.6 ms and 58.1±2.3 ms for the anterior AF; 67.0±4.6 ms and 59.6±2.1 ms for NP; and 70.7±4.6 ms and 51.0±1.2 ms for the posterior AF, respectively. T2 values for IVDD were significantly lower in the NeP group than those in the NocP group (p<0.01). CONCLUSIONS: The results indicate a correlation between the degeneration of posterior AF and NeP. MRI T2 mapping may be beneficial for detecting NeP caused by IVDD and can help formulate targeted analgesic therapies.

骨付き膝蓋腱を用いた長方形骨孔前十字靱帯再建術における生体吸収スクリューの安全性の検討
塩泡 孝介, 鈴木 智之, 松村 崇史, 山下 敏彦, 高島 弘幸, 大坪 英則
整形・災害外科, 62, 6, 791, 796, 金原出版(株), May 2019
Japanese, ＜文献概要＞本調査の目的は,生体吸収性インターフェランススクリュー(B-IFS)により大腿骨側の固定を行った骨付き膝蓋腱を用いた長方形骨孔前十字靱帯再建術(RT BTB法)について,術後1年のCTによる合併症調査を行い,安全性を検討することである。対象は,RT BTB法を施行され,術後2週目と術後1年目にCTを撮影した29膝である。平均年齢は32.1歳,男性14膝であった。術後1年のCTにて合併症(骨嚢胞形成,術後のB-IFSの折損や脱転,移植骨片脱転)の有無を調査した。術後2週と術後1年のCTの大腿骨骨孔開口部面積を比較した。骨嚢胞形成,術後のB-IFS折損や脱転,移植骨片脱転を認めた例はなく,骨孔面積の変化は平均で1.1±22.8%で有意な骨孔拡大を認めなかった。B-IFSを用いたRT BTB法では,骨嚢胞形成などの合併症や有意な骨孔拡大を認めず,安全性が確認された。

Quantitative Analysis Concerning Atrophy and Fat Infiltration of the Multifidus Muscle with Magnetic Resonance Spectroscopy in Chronic Low Back Pain.
Izaya Ogon, Tsuneo Takebayashi, Hiroyuki Takashima, Tomonori Morita, Mitsunori Yoshimoto, Yoshinori Terashima, Toshihiko Yamashita
Spine surgery and related research, 3, 2, 163, 170, JAPANESE SOC SPINE SURGERY & RELATED RESEARCH, 27 Apr. 2019, [Domestic magazines]
English, Scientific journal, INTRODUCTION: Magnetic resonance spectroscopy (MRS) enables detailed analysis of the composition of muscular fat tissues such as intramyocellular lipids (IMCLs) and extramyocellular lipids (EMCLs). The aim of this study was to analyze the EMCL and IMCL of the multifidus muscle (Mm) using MRS in chronic low-back pain (CLBP) patients and identify their possible correlations with age, body mass index (BMI), low-back pain (LBP) visual analog scale (VAS) score, cross-sectional area (CSA), and fat infiltration of the Mm. METHODS: Eighty patients (32 men and 48 women; mean age, 64.7 ± 1.3 years; range, 22-83 years) with VAS scores >30 mm for CLBP were included. We analyzed the gender difference and the possible correlations of age, BMI, LBP VAS, CSA, and fat infiltration of the Mm with the IMCL and EMCL of the Mm. The subjects were divided into five groups as per their age range: < 40s, 50s, 60s, 70s, and 80s. We also analyzed the EMCL and IMCL of the Mm as per the fat infiltration classification. RESULTS: CSA was larger in the male group, EMCL was higher in the female group, and there was no significant difference in IMCL between the female and male groups. There was a significant positive correlation of EMCL with age (r = 0.33, p < 0.01) and BMI (r = 0.42, p < 0.01) and a significant negative correlation of EMCL with CSA (r = -0.61, p < 0.01). There was a significant positive correlation between IMCL and VAS (r = 0.43, p < 0.01). The EMCL and CSA of the Mm decreased with age, whereas fat infiltration increased with age. CONCLUSIONS: These results suggest that EMCL could indicate Mm degeneration associated with aging, and IMCL could be an effective objective indicator of CLBP. The EMCL and IMCL of the Mm may be useful prognostic markers in rehabilitation strategies.

【整形外科診療における最先端技術】診断、評価 新しい画像・機能診断 MRI定量的画像法(T1ρ、T2、T2*)による椎間板変性の評価
高島 弘幸, 吉本 三徳, 竹林 庸雄, 今村 塁, 赤塚 吉紘, 山下 敏彦
別冊整形外科, 75, 16, 19, (株)南江堂, Apr. 2019, [Lead author, Corresponding author]
Japanese

椎体骨折におけるintravoxel incoherent motion(IVIM)パラメータの解析　　　　　　　　　　　　　　　
今村 塁, 高島 弘幸, 竹林 庸雄, 吉中 宣康, 赤塚 吉紘
北海道放射線技術雑誌, 86, 34, 35, (公社)日本放射線技術学会-北海道支部, Apr. 2019
Japanese

足関節外側靱帯 isotropic 3D fast spin-echoとbalanced fast field-echoの比較　　　　　　　　　　　　　　　
赤塚 吉紘, 高島 弘幸, 今村 塁, 中西 光広
北海道放射線技術雑誌, 86, 44, 45, (公社)日本放射線技術学会-北海道支部, Apr. 2019
Japanese

胃CT perfusionにおける撮影間隔による解析精度の評価　　　　　　　　　　　　　　　
沼澤 香夏子, 原田 耕平, 大橋 芳也, 千葉 彩佳, 今井 達也, 早坂 駿, 大森 剛, 伊藤 彩, 高島 弘幸
北海道放射線技術雑誌, 86, 30, 31, (公社)日本放射線技術学会-北海道支部, Apr. 2019, [Peer-reviewed], [Last author]
Japanese

Optimization of MR Signal Contrast of the Lumbar Cartilaginous Endplates Using Ultra-Short TE
Hiroyuki Takashima, Mika Yanagida, Rui Imamura, Mitsunori Yoshimoto, Izaya Ogon, Mitsuhiro Nakanishi, Yoshihiro Akatsuka, Tomoyuki Okuaki, Masami Yoneyama, Masamitsu Hatakenaka, Toshihiko Yamashita
APPLIED MAGNETIC RESONANCE, 50, 1-3, 381, 389, SPRINGER WIEN, Mar. 2019
English, Scientific journal, The ultra-short TE (UTE) technique has been recently used to investigate lumbar cartilaginous endplates (CEPs). However, parameters of UTE have not been investigated, especially optimal second TE is unclear. The aim of this study was to investigate the use of an optimal second TE with UTE for visualizing CEPs. The subjects included 20 volunteers without LBP who did not undergo lumbar spine surgery. A UTE sequence with fat suppression was used, and TEs were set at 0.16ms as first TE, and 4.6, 9.2, 13.8, 18.2ms as second TE. Analyzed images subtracted each second TE image from first TE image. Two researchers measured contrast ratio (CR) between CEPs and vertebral bodies (VBs), intervertebral discs (IVDs). ICCs between two researchers were calculated for CRs (r=0.924, 0.939). CR between CEP and VB of 13.8 and 18.4ms was significantly higher than that of other TEs (p<0.01). CR between CEP and IVD of 9.2 and 13.8ms was significantly higher than that of other TEs (p<0.01, 0.05). CEPs were evaluated using subtraction images obtained with UTE. The first TE was 0.16ms, the optimal second TE was suggested to be 13.8ms for evaluating human CEPs.

3D MRIを用いた足関節外側靱帯の腓骨側付着部の検討　　　　　　　　　　　　　　　
赤塚 吉紘, 寺本 篤史, 高島 弘幸, 神谷 智昭, 渡邉 耕太, 山下 敏彦
日本整形外科学会雑誌, 93, 2, S153, S153, (公社)日本整形外科学会, Mar. 2019
Japanese

Morphological evaluation of the calcaneofibular ligament in different ankle positions using a three-dimensional MRI sequence.
Yoshihiro Akatsuka, Atsushi Teramoto, Hiroyuki Takashima, Kota Watanabe, Toshihiko Yamashita
Surgical and radiologic anatomy : SRA, 41, 3, 307, 311, SPRINGER FRANCE, Mar. 2019, [International Magazine]
English, Scientific journal, PURPOSE: Evaluating images of the lateral ligament of the ankle is not easy, and evaluation of the calcaneofibular ligament (CFL) in particular is difficult. We prospectively conducted morphological measurements of the CFL in different ankle positions and obtain basic data for use in functional assessment of the CFL, diagnosis of CFL injury, and determination of treatment effects. METHODS: The subjects were ten healthy volunteers (ten ankles) with a mean age of 27.8 years and no history of ankle disease. Imaging was done using a 3-T magnetic resonance imaging (MRI) machine and fast imaging employing steady-state acquisition cycled phases (FIESTA-C), a three-dimensional (3D) sequence, with the ankle in a neutral position, maximum dorsiflexion, and maximum plantar flexion. 3D images of the CFL, peroneal muscle tendons, fibula, and calcaneus were prepared at a workstation, and morphological measurements of the CFL were made. RESULTS: In all positions, the CFL showed a gently curving course with the peroneal muscle tendons as a fulcrum. The tortuosity angle was significantly smaller in plantar flexion (30.0° ± 7.4°) than in the neutral position (41.7° ± 8.3°). CONCLUSIONS: 3D MRI sequences showed that, in all positions, the CFL curved due to the influence of the peroneal muscle tendons. With maximum plantar flexion, the CFL tortuosity angle was small, which was thought to have been due to the tension in the CFL.

足関節外側靱帯におけるMRI 3Dシーケンスの比較
赤塚 吉紘, 高島 弘幸, 今村 塁, 中西 光広, 寺本 篤史, 神谷 智昭, 山下 敏彦, 渡邉 耕太
北海道整形災害外科学会雑誌, 61, 137th suppl, 69, 69, 北海道整形災害外科学会, 2019
Japanese

【腰痛治療の最前線】腰痛の診断 MRIを用いた腰痛の可視化の可能性
高島 弘幸, 山下 敏彦
関節外科, 37, 12, 1310, 1317, (株)メジカルビュー社, Dec. 2018, [Lead author, Corresponding author]
Japanese, 最近の画像診断機器の進歩は著しく、MRIでは、さまざまな定量的画像解析法が開発されている。椎間板におけるT2、T1rho、T2*mapや終板イメージング、傍脊柱筋の脂肪量解析など多くの報告があり、腰痛との関連について研究されている。主観的な腰痛をこれらの画像解析法により客観的に可視化するためにはまだ課題があるが、新たな診断法として病態の解明や治療法の開発につながることを期待する。(著者抄録)

Differentiating spinal intradural-extramedullary schwannoma from meningioma using MRI T2 weighted images.
Hiroyuki Takashima, Tsuneo Takebayashi, Mitsunori Yoshimoto, Maki Onodera, Yoshinori Terashima, Noriyuki Iesato, Katsumasa Tanimoto, Izaya Ogon, Tomonori Morita, Toshihiko Yamashita
The British journal of radiology, 91, 1092, 20180262, 20180262, BRITISH INST RADIOLOGY, Dec. 2018, [Lead author, Corresponding author], [International Magazine]
English, Scientific journal, OBJECTIVE:: Prior studies advocate the subjective visual differences between meningioma and schwannoma on T2 weighted images, however objective measurement of signal intensity differences may be useful in certain cases. The aim of this study was to investigate whether an objective evaluation of SIs on T2 weighted images would be useful to differentiate spinal schwannomas from meningiomas. METHODS:: The patients with spinal MRIs demonstrating path proven and subsequently treated intradural extramedullary spinal tumors were selected between April 2008 and May 2017. Regions of interest (ROIs) were measured in the tumor and subcutaneous fat on the same image, and we calculated the SI ratio between tumor and fat ROIs. RESULTS:: Twenty patients each with meningioma and schwannoma were enrolled. The SI ratios of schwannomas were significantly higher than those of meningiomas (both researcher 1 and 2: p = 0.002). The areas under the curve by researchers 1 and 2 were 0.780. The cutoff value of SI ratio by both of researchers 1 and 2 to differentiate between schwannomas from meningiomas was 0.420 (sensitivity: 80.0%, specificity: 70.0-75.0%). CONCLUSION:: The SI ratio, calculated from the SIs of the tumor and fat on T2 weighted images, is useful for differentiating spinal schwannomas from meningiomas to obtain an accurate diagnosis. ADVANCES IN KNOWLEDGE:: Signal intensity ratio of the spinal tumor and fat on T2 weighted images is useful for differentiating schwannomas from meningiomas to obtain an accurate diagnosis.

The Difference in Gender Affects the Pathogenesis of Ligamentum Flavum Hypertrophy.
Hiroyuki Takashima, Tsuneo Takebayashi, Mitsunori Yoshimoto, Maki Onodera, Izaya Ogon, Tomonori Morita, Noriyuki Iesato, Yoshinori Terashima, Katsumasa Tanimoto, Toshihiko Yamashita
Spine surgery and related research, 2, 4, 263, 269, JAPANESE SOC SPINE SURGERY & RELATED RESEARCH, 26 Oct. 2018, [Lead author, Corresponding author], [Domestic magazines]
English, Scientific journal, INTRODUCTION: Gender differences may play a role in the pathogenesis of lumbar spinal stenosis. However, few reports that discuss the effects of gender differences in ligamentum flavum (LF) hypertrophy have been published, and no study has investigated the relationship between LF thickness and the quantitative value of intervertebral disc (IVD) degeneration. This study aimed to investigate the impact of gender on the pathomechanisms underlying LF hypertrophy, focusing on the relationship among LF thickness, IVD degeneration, and age. METHODS: The subjects include 100 patients with low back pain and leg numbness, tingling, or pain. We measured LF thickness and the T2 values of IVDs using MR imaging and analyzed the relationship among LF thickness, T2 values of IVDs, and age. The interclass correlation coefficient (ICC) was calculated as the inter-rater reliability between the LF thickness values measured by two investigators. RESULTS: ICC was calculated for the two measurements of LF thickness (r = 0.923, 95% CI: 0.907-0.936). No statistically significant difference in the T2 values of IVDs was observed between females and males from L2/3 to L5/S. There were significantly negative linear correlations between LF thickness and the T2 values of IVDs at all levels, but this correlation was not observed in females at L4/5. There were significantly negative linear correlations between age and the T2 values of IVDs from L2/3 to L5/S for all patients, females, and males (r = 0.422-0.756). In addition, there were significantly positive linear correlations between age and LF thickness from L2/3 to L4/5 for all patients (r = 0.329-0.361) and females (r = 0.411-0.481). Correlations were not observed for males at all levels or for all patients at L5/S. CONCLUSIONS: The relationships identified among LF thickness, age, and IVD degeneration suggest that gender differences play a role in the pathogenesis of LF hypertrophy.

男性骨盤の前方CE角は年齢とともに増大する
鈴木 大輔, 名越 智, 岡崎 俊一郎, 喜沢 史弥, 高島 弘幸, 舘田 健児, 小助川 維摩, 佐々木 幹人, 山下 敏彦
北海道整形災害外科学会雑誌, 60, 1, 149, 150, 北海道整形災害外科学会, Aug. 2018
Japanese

Cutting Edge on Clinical Management of Chronic Lateral Ankle Instability MR Imaging of Chronic Lateral Ankle Instability MRIで何がわかるか　　　　　　　　　　　　　　　
寺本 篤史, 赤塚 吉紘, 高島 弘幸, 小路 弘晃, 榊原 醸, 神谷 智昭, 渡邉 耕太, 山下 敏彦
JOSKAS, 43, 4, 456, 456, (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2018
Japanese

TKA術前および術後における大腿筋断面積と術後の疼痛・満足度との関係
赤塚 吉紘, 高島 弘幸, 今村 塁, 寺本 篤史, 鈴木 智之, 岡田 葉平, 木井 雄一郎, 山下 敏彦, 渡邉 耕太
北海道整形災害外科学会雑誌, 59, 2, 285, 285, 北海道整形災害外科学会, Mar. 2018
Japanese

Analysis of intra and extramyocellular lipids in the multifidus muscle in patients with chronic low back pain using MR spectroscopy
Hiroyuki Takashima, Tsuneo Takebayashi, Izaya Ogon, Mitsunori Yoshimoto, Tomonori Morita, Rui Imamura, Mitsuhiro Nakanishi, Hiroshi Nagahama, Yoshinori Terashima, Toshihiko Yamashita
British Journal of Radiology, 91, 1083, 20170536, 20170536, British Institute of Radiology, 2018, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
English, Scientific journal, Objective: To analyse the intra- (IMCL) and extramyocellular lipids (EMCL) concentration in the multifidus muscle (Mm) using MR spectroscopy (MRS) in patients with low back pain (LBP), and to evaluate the correlation between those lipid concentrations and age, obesity, atrophy of the Mm and LBP intensity. Methods: 60 LBP patients underwent routine diagnostic MRI of the lumbar spine before undergoing imaging for the study. Body mass index, as an indicator of obesity and visual analogue scale, as an indicator of LBP were also measured. Proton MRS was acquired with a single-voxel point-resolved spectroscopy sequence. Furthermore, the MRS volume of interest for measuring the IMCL and EMCL concentration at L4/5 for the right Mm was determined, and we measured the cross-sectional area of Mm as an indicator of muscle atrophy. Results: Age showed correlation with EMCL concentration (r = 0.314, p = 0.008). The body mass index showed correlation with EMCL concentration (r = 0.358, p = 0.005). The cross-sectional area of Mm showed correlation with EMCL concentration (r = −0.543, p <
0.001). Moreover, the LBP visual analogue scale showed correlation with IMCL concentration (r = 0.367, p = 0.004). Conclusion: There were correlations between age, obesity, muscle atrophy, and EMCL concentration in Mm. IMCL concentration in Mm showed a correlation with LBP intensity. This may suggest that IMCL concentration could become an effective objective indicator of chronic LBP intensity.

男性骨盤の前方CE 角は年齢とともに増大する
鈴木大輔, 名越智, 喜沢史弥, 高島弘幸, 舘田健児, 小助川維摩, 佐々木幹人, 岡崎俊一郎, 山下敏彦
Hip Joint, 44, 1, 309, 313, 日本股関節学会, 2018
Japanese, Scientific journal, 大腿骨被覆は股関節疾患と深い関わりがあり、近年は大腿骨寛骨臼インピンジメント(FAI)と骨形態の関わりが多く研究されている。FAIの臨床症状として、股関節の前部痛、屈曲内旋で痛み増強などが挙げられ、これらは股関節前方の骨形態と強く関連している。著者等は以前、正常股関節例のherniation pit存在率について調査し、50～60歳代で最も高かった。これらのことから、正常人の大腿骨の前方被覆は高齢になると変化するのではないかと考え、検証を行った。方法は、当院に検診目的で来院した日本人120名(男性60名、女性60名、年齢15～79歳)のCT画像を用い、3D画像ソフトで三次元構築し、「骨盤傾斜」「前方CE角」「後方CE角」を計測した。その結果、男女とも加齢に伴って骨盤が有意に後傾し、また男性のみ加齢に伴って前方CE角が有意に増大した。前方CE角の増大はFAIの発生に関係している可能性が示唆された。

Three cases of implantation of a SureScan(A (R)) system and MRI for investigating causes of pain
Kazunobu Takahashi, Atsushi Sawada, Soshi Iwasaki, Naoya Yama, Hiroyuki Takashima, Maki Onodera, Masamitsu Hatakenaka, Michiaki Yamakage
JOURNAL OF ANESTHESIA, 31, 6, 915, 917, SPRINGER JAPAN KK, Dec. 2017, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, We report three cases of implantation of the SureScan(A (R)) system and magnetic resonance imaging (MRI) for investigating causes of pain. Although there were metal-induced artifacts on the MR images of 2 patients, the artifacts did not affect the images of structures that needed to be assessed to make the diagnosis. The SureScan(A (R)) system enabled patients implanted with spinal cord stimulation devices to undergo MRI.

特集 高齢者脊椎疾患の診断･治療の最近の進歩 診断 MRIによる定量的画像解析法を用いた椎間板および傍脊柱筋の解析
高島 弘幸, 山下 敏彦
関節外科, 36, 14, 19, 25, (株)メジカルビュー社, 01 Oct. 2017, [Lead author, Corresponding author]
Japanese

変形性足関節症モデルラットにおけるヒアルロン酸ナトリウムの効果
神保 俊介, 寺島 嘉紀, 竹林 庸雄, 黄金 勲矢, 高島 弘幸, 寺本 篤史, 渡邉 耕太, 當瀬 規嗣, 山下 敏彦
Journal of Musculoskeletal Pain Research, 9, 3, S34, S34, (一社)日本運動器疼痛学会, Oct. 2017
Japanese

Three-dimensional orientation of the acetabulum
Daisuke Suzuki, Satoshi Nagoya, Hiroyuki Takashima, Kenji Tateda, Toshihiko Yamashita
CLINICAL ANATOMY, 30, 6, 753, 760, WILEY, Sep. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, This study was designed specifically to determine the normal acetabular orientation and femoral head covering, and whether these are affected by age or sex. Computed tomographic images of normal Japanese hip joints were used (males 60, females 60; mean age 48.3 years, range 15-79 years). Male and female age profiles were matched. The reconstructed 3-D pelvic images were aligned in the anatomical pelvic coordinate system. The acetabular orientation angles and femoral covering angles were measured in the sagittal, coronal, and horizontal planes. In the sagittal plane, the acetabular orientation angle was operative anteversion (O-av), and the femoral covering angles were the anterior and posterior center-edge angles (ACE and PCE). In the coronal plane, they were the Sharp angle (SA) and the lateral center-edge angle (LCE). In the horizontal plane, they were anatomical anteversion (A-av) and the anterior and posterior sector angles (ASA and PSA). The O-av, SA, and A-av were smaller in the male than the female acetabulum (P<0.01). SA in both males and females was inversely correlated with age (P<0.01). Both male PCE and PSA were significantly smaller than those of females, while male ASA was larger than female ASA (P<0.05). The male acetabulum is directed further outward and downward than the female one. However, this does not indicate that the male acetabulum covers the femoral head more, because there is no significant sex difference in the LCE. Femoral coverage is more posteriorly biased in females than in males owing to pelvic inclination. Clin. Anat. 30:753-760, 2017. (c) 2017Wiley Periodicals, Inc.

日本人正常寛骨臼による三次元大腿骨被覆　　　　　　　　　　　　　　　
鈴木 大輔, 名越 智, 高島 弘幸, 舘田 健児, 小助川 維摩, 佐々木 幹人, 岡崎 俊一郎, 山下 敏彦
日本整形外科学会雑誌, 91, 8, S1545, S1545, (公社)日本整形外科学会, Aug. 2017
Japanese

ストレス撮影は必要である 踵腓靱帯に着目した新たな画像診断ツール3D MRIに加えて　　　　　　　　　　　　　　　
寺本 篤史, 赤塚 吉紘, 高島 弘幸, 渡邉 耕太, 山下 敏彦
日本整形外科スポーツ医学会雑誌, 37, 2, 116, 119, (一社)日本整形外科スポーツ医学会, May 2017
Japanese, 足関節外側靱帯損傷は適切な保存治療によりスポーツ活動への復帰が可能であるが、重度損傷はスポーツ競技復帰まで長期間を要したり、手術が必要になることがある。重症度は踵腓靱帯(CFL)損傷の有無によって定義される。ストレス撮影は画像診断として広く行なわれているが、ストレス撮影単独での評価には限界があり、筆者らはストレス撮影と3D MRIの組み合わせによってCFLを中心とした足関節外側靱帯損傷の詳細な評価を行ってきた。その結果、手術の必要性や手術手技の選択における有用性が高まり、足関節外側靱帯損傷の治療選択に応用可能と考えられた。(著者抄録)

プリパルス印加型連結T1rho/T2マッピングシーケンスにおける印加時間が計測値に与える影響　　　　　　　　　　　　　　　
今村 塁, 高島 弘幸, 奥秋 知幸, 中西 光広, 宍戸 博紀, 赤塚 吉紘
北海道放射線技術雑誌, 82, 71, 72, (公社)日本放射線技術学会-北海道支部, Mar. 2017
Japanese

MRI depiction and 3D visualization of three anterior cruciate ligament bundles.
H Otsubo, Y Akatsuka, H Takashima, T Suzuki, D Suzuki, T Kamiya, Y Ikeda, T Matsumura, T Yamashita, K Shino
Clinical anatomy (New York, N.Y.), 30, 2, 276, 283, Mar. 2017, [International Magazine]
English, Scientific journal, The anterior cruciate ligament (ACL) is divided into three fiber bundles (AM-M: anteromedial-medial, AM-L: anteromedial-lateral, PL: posterolateral). We attempted to depict the three bundles of the human ACL on MRI images and to obtain 3-dimensional visualization of them. Twenty-four knees of healthy volunteers (14 males, 10 females) were scanned by 3T-MRI using the fat suppression 3D coherent oscillatory state acquisition for the manipulation of imaging contrast (FS 3D-COSMIC). The scanned images were reconstructed after the isotropic voxel data, which allows the images to be reconstructed in any plane, was acquired. We conducted statistical examination on the identification rate of the three ACL bundles by 2D planes. Segmentation and 3D visualization of the fiber bundles using volume rendering were performed. The triple-bundle ACL was best depicted in the oblique axial plane. While the AM-M and AM-L bundles were clearly depicted in all cases, the PL bundle was not clearly visualized in two knees (8%). Therefore, the three ACL bundles were depicted in 22 knees (92%). The results of 3D visualization of the fiber arrangement agreed well with macroscopic findings of previous anatomical studies. 3T-MRI and the isotropic voxel data from FS 3D-COSMIC made it possible to demonstrate the identifiable depiction of three ACL bundles in nearly all cases. 3D visualization of the bundles could be a useful tool to understand the ACL fiber arrangement. Clin. Anat. 30:276-283, 2017. 2016 The Authors. Clinical Anatomy published by Wiley Periodicals, Inc. on behalf of American Association of Clinical Anatomists.

寛骨臼形成不全患者と正常者の後方被覆の比較　　　　　　　　　　　　　　　
鈴木 大輔, 喜沢 史弥, 名越 智, 高島 弘幸, 舘田 健児, 小助川 維摩, 佐々木 幹人, 岡崎 俊一郎, 山下 敏彦
日本整形外科学会雑誌, 91, 2, S533, S533, (公社)日本整形外科学会, Mar. 2017
Japanese

人工膝関節置換術後の疼痛と術前大腿部筋断面積の関係
赤塚 吉紘, 高島 弘幸, 今村 塁, 寺本 篤史, 鈴木 智, 岡田 葉平, 木井 雄一郎, 山下 敏彦, 渡邉 耕太
北海道整形災害外科学会雑誌, 58, 2, 258, 258, 北海道整形災害外科学会, Mar. 2017
Japanese

TKA術前および術後における大腿筋断面積と術後の疼痛・満足度との関係　　　　　　　　　　　　　　　
赤塚 吉紘, 寺本 篤史, 高島 弘幸, 鈴木 智之, 岡田 葉平, 木井 雄一郎, 今村 塁, 渡邉 耕太, 山下 敏彦
日本整形外科学会雑誌, 91, 3, S910, S910, (公社)日本整形外科学会, Mar. 2017
Japanese

特集 次の25年の放射線治療の進歩を見据えて 放射線技術学と日本放射線技術学会の発展に向けて
高島 弘幸
臨床放射線, 62, 2, 265, 268, 金原出版, 10 Feb. 2017, [Lead author, Corresponding author]
Japanese

Efficacy of intraoperative direct electrical stimulation of the spinal root and measurement of distal motor latency in lumbar spinal stenosis
Takao Murohashi, Mitsunori Yoshimoto, Tsuneo Takebayashi, Shuichi Hashimoto, Shouto Yamada, Hiroyuki Takashima, Toshihiko Yamashita
EUROPEAN SPINE JOURNAL, 26, 2, 434, 440, SPRINGER, Feb. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, The measurement of distal motor latency (DML) is an established method for diagnosing entrapment peripheral neuropathy. DML can also serve as an index for disease severity and prognosis. We considered that measuring DML could be useful in estimating the severity of spinal root impairment and predicting prognosis in patients with lumbar spinal stenosis (LSS). The purpose of this study was to investigate the efficacy of intraoperative direct electrical stimulation of the spinal root and the measurement of DML in LSS.
In 39 patients with LSS, a total of 93 spinal roots were stimulated, and evoked electromyography was recorded at the leg muscles after decompression. DML was measured and its correlation with clinical severity, as evaluated by Zurich claudication questionnaire (ZCQ) and Short Form 36 (SF-36), was investigated.
For the stimulation of the L3, L4, and L5 spinal root, the mean DML (ms) were 6.8 (+/- 1.4), 7.4 (+/- 1.3), and 6.0 (+/- 1.3) in gluteus medius, 9.3 (+/- 1.5), 9.2 (+/- 1.5), and 9.0 (+/- 1.6) in biceps femoris, 9.7 (+/- 1.0), 9.8 (+/- 1.8), and 9.4 (+/- 1.2) in vastus medialis, 16.1 (+/- 1.0), 14.7 (+/- 1.3), and 14.1 (+/- 1.5) in tibialis anterior, and 16.4 (+/- 1.4), 14.3 (+/- 1.8), and 13.9 (+/- 1.9) in gastrocnemius muscles. Statistically significant positive correlations were observed between DML and height. Preoperative symptom and function scores of ZCQ and postoperative bodily pain scores of SF-36 were significantly worse in the patients with prolonged DML.
DML is thought to be useful for estimating the severity of spinal root impairment and for predicting the prognosis.

Improvement effect of low back pain with microendoscopic decompression for lumbar spinal stenosis: Comparison with degenerative spondylolisthesis and pattern of neurological disorder
Ogon Izaya, Takebayashi Tsuneo, Yoshimoto Mitsunori, Takashima Hiroyuki, Morita Tomonori, Terashima Yoshinori, Yamashita Toshihiko
PAIN RESEARCH, 32, 3, 203, 211, JAPANESE ASSOCIATION FOR STUDY OF PAIN, 2017
Japanese, Scientific journal,

Sixty–five patients (45 male, 20 female; mean age: 71.7 ± 0.9) who under­went microendoscopic muscle preserving interlaminar decompression for lumbar spinal stenosis (LSS) were classified according to degenerative spondylolisthesis and pattern of neurological disorder. We estimated concerning clinical results and association between low back pain (LBP) and lumbar lordosis (LL). Postoperatively, leg symptom as well as LBP significantly improved in all groups. The improvement of LBP was significantly correlated with the increase of LL. Lumbar decompression for LSS may improve LBP and the lumbar alignment regardless of spondylolisthesis and pattern of neurological disorder.

Magnetic resonance spectroscopic analysis of multifidus muscles lipid content and association with spinopelvic malalignment in chronic low back pain
Izaya Ogon, Tsuneo Takebayashi, Hiroyuki Takashima, Tomonori Morita, Mitsunori Yoshimoto, Yoshinori Terashima, Toshihiko Yamashita
BRITISH JOURNAL OF RADIOLOGY, 90, 1073, 20160753, 20160753, BRITISH INST RADIOLOGY, 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, Objective: To analyze intramyocellular lipids (IMCLs) and extramyocellular lipids (EMCLs) of the multifidus muscle (Mm) using MR spectroscopy in chronic low back pain (CLBP) and control groups and to identify correlations with spinopelvic alignment.
Methods: 40 patients (16 males, 24 females; mean age, 62.9 +/- 1.9 years) whose visual analogue scale scores were > 30mm for CLBP were included. Furthermore, 40 control participants matched with the CLBP group subjects by sample size, gender and age (17 males, 23 females; mean age, 65.0 +/- 1.2 years) were included. We compared the body mass index, physical workload, leisure time physical activity level, spinopelvic parameters, and IMCLs and EMCLs of the Mm between the groups. We also evaluated possible correlations of spinopelvic parameters with IMCLs and EMCLs of the Mm in the groups.
Results: There were no statistically significant differences in body mass index, physical workload, exercise intensity level, spinopelvic parameters and EMCLs between the groups. The IMCLs were significantly higher in the CLBP group than in the control group (p < 0.01). In the CLBP group, there was a significantly negative correlation between IMCLs and lumbar lordosis (r = 0.64, p < 0.01) and a significantly positive correlation between IMCLs and sagittal vertical axis (r = 0.43, p < 0.01).
Conclusion: The measurement of IMCLs might be a characteristic finding of CLBP as well as a precursor to spinal deformity.

陳旧性足関節外側靱帯損傷の3D MRI所見
寺本 篤史, 榊原 醸, 鈴木 智之, 山下 敏彦, 赤塚 吉紘, 高島 弘幸, 渡邉 耕太
北海道整形災害外科学会雑誌, 58, 1, 138, 138, 北海道整形災害外科学会, Oct. 2016
Japanese

機能的骨盤座標系から解剖学的骨盤座標系の変換で寛骨臼オリエンテーションはどう変化するのか　　　　　　　　　　　　　　　
鈴木 大輔, 名越 智, 高島 弘幸, 佐々木 幹人, 岡崎 俊一郎, 加谷 光規, 舘田 健児, 小助川 維摩, 大西 史師, 山下 敏彦
Hip Joint, 42, 2, 954, 958, 日本股関節学会, Aug. 2016
Japanese, 日本人の正常股関節120例の骨盤CT画像を3D画像ソフトを用いて三次元構築画像に変換し、3D-CADソフトに取込み計測、座標変化して機能的骨盤肢位(FPP)と解剖学的骨盤肢位(APP)での寛骨臼オリエンテーションを計測した。また、骨盤傾斜角とFPPでの寛骨臼オリエンテーションを用いてAPPでの寛骨臼オリエンテーションの予測式を算出した。その結果、FPPでの寛骨臼オリエンテーションの計測値はAPPでの計測値に比べ、標準偏差および男女差が小さかった。これは解剖学的な寛骨臼オリエンテーションの男女差を、骨盤傾斜の調整により代償していることを示していると考えられた。また、APPの寛骨臼オリエンテーションの予測式は、骨盤傾斜角(FPPでのanterior pelvic planeと冠状面のなす角)とFPPの角度から精度よく求められ、寛骨臼形態の比較に有用であると考えられた。

足関節外側靱帯損傷に対する治療戦略 ストレス撮影は必要である 踵腓靱帯に着目した新たな画像診断ツール3D MRIに加えて　　　　　　　　　　　　　　　
寺本 篤史, 赤塚 吉紘, 高島 弘幸, 渡邉 耕太, 山下 敏彦
日本整形外科スポーツ医学会雑誌, 36, 4, 328, 328, (一社)日本整形外科スポーツ医学会, Aug. 2016
Japanese

The signal intensity ratio of the optic nerve to ipsilateral frontal white matter is of value in the diagnosis of acute optic neuritis
Maki Onodera, Naoya Yama, Masato Hashimoto, Takaharu Shonai, Kazunori Aratani, Hiroyuki Takashima, Ken-ichi Kamo, Hiroshi Nagahama, Hiroshi Ohguro, Masamitsu Hatakenaka
EUROPEAN RADIOLOGY, 26, 8, 2640, 2645, SPRINGER, Aug. 2016, [Peer-reviewed], [International Magazine]
English, Scientific journal, To evaluate the usefulness of the signal intensity ratio (SIR) of the optic nerve to the white matter (WM) on short tau inversion recovery (STIR) images to diagnose acute optic neuritis (AON).
The 405 consecutive patients with suspected orbital diseases underwent orbital magnetic resonance imaging (MRI) using a 3-T scanner between June 2008 and August 2011. Among them, 108 optic nerves (33 AON and 75 control) were retrospectively analysed. The averaged SIR (SIRave) and maximum SIR (SIRmax) were defined as the averaged signal intensity (SI) of the optic nerve divided by that of WM, and the maximum SI of the optic nerve divided by averaged SI of WM, respectively. These values were compared between AON and control using the Mann-Whitney U test. A P < 0.05 was considered statistically significant.
SIRave and SIRmax were significantly (P < 0.001) higher in the AON compared to the control. At a cut-off SIRave value of 1.119, the sensitivity, specificity and accuracy were 0.939, 0.840, and 0.870; and at a cut-off SIRmax value of 1.281, these were 1.000, 0.720 and 0.806, respectively.
The SIR of the optic nerve to WM on STIR images is of value in diagnosing AON.
aEuro cent We propose a method of diagnosing acute optic neuritis using 3-T MRI.
aEuro cent Our method is simple and objective and requires no novel imaging techniques.
aEuro cent Our method shows high diagnostic accuracy.

無線型FPDの線量低減に関する検討 画像特性によるCRとの比較　　　　　　　　　　　　　　　
次木 嵩人, 早坂 駿, 今村 塁, 赤塚 吉紘, 佐藤 順一, 赤石 泰一, 高島 弘幸, 宍戸 博紀
北海道放射線技術雑誌, 80, 94, 95, (公社)日本放射線技術学会-北海道支部, Apr. 2016
Japanese

無線型FPDの線量低減に関する検討 人体ファントムによるCRとの比較　　　　　　　　　　　　　　　
早坂 駿, 次木 嵩人, 今村 塁, 赤塚 吉紘, 佐藤 順一, 赤石 泰一, 高島 弘幸, 宍戸 博紀
北海道放射線技術雑誌, 80, 96, 97, (公社)日本放射線技術学会-北海道支部, Apr. 2016
Japanese

balanced SSFPシーケンスを用いた足関節肢位による踵腓靱帯の評価　　　　　　　　　　　　　　　
赤塚 吉紘, 寺本 篤史, 高島 弘幸, 宍戸 博紀, 今村 塁, 柳田 美香
北海道放射線技術雑誌, 80, 44, 45, (公社)日本放射線技術学会-北海道支部, Apr. 2016
Japanese

3D MRIを用いた足関節外側靱帯損傷の経時的評価
寺本 篤史, 榊原 醸, 鈴木 智之, 山下 敏彦, 赤塚 吉紘, 高島 弘幸, 渡邉 耕太
北海道整形災害外科学会雑誌, 57, 2, 333, 333, 北海道整形災害外科学会, Apr. 2016
Japanese

Bucket handle損傷型半月に対する関節鏡下縫合術後の治療成績
久保田 ちひろ, 鈴木 智之, 岡田 葉平, 木井 雄一郎, 寺本 篤史, 渡邉 耕太, 山下 敏彦, 高島 弘幸, 今村 塁, 大坪 英則, 小笠原 一洋, 杉 憲
北海道整形災害外科学会雑誌, 57, 2, 395, 395, 北海道整形災害外科学会, Apr. 2016
Japanese

【足関節・足部疾患の最新治療】疾患各論 外傷・スポーツ障害 足関節外側靱帯損傷 3D-MRIを用いた新鮮足関節外側靱帯損傷の評価
寺本 篤史, 赤塚 吉紘, 高島 弘幸, 鈴木 智之, 渡邉 耕太, 山下 敏彦
別冊整形外科, 69, 207, 210, (株)南江堂, Apr. 2016
Japanese, 3D-MRIを用いて正常ボランティア10例の足関節外側靱帯の形態学的計測を行なった。また、あわせて新鮮足関節外側靱帯損傷4例における損傷部位と治療過程の評価を行った。その結果、1)3D-MRIを用いることで正常ボランティアの前距腓靱帯(ATFL)と踵腓靱帯(CFL)は全長にわたって明瞭に描出され、ATFLの幅は平均4.0mm、CFLの幅は平均4.8mmであった。2)靱帯損傷患者のATFLは受傷直後に高信号変化を伴う靱帯途絶所見があり、経時的に高信号を伴うびまん性膨化を示した。ATFLの幅は受傷直後平均5.8mm、4週後は平均7.1mm、8週後は平均8mmであった。3)CFLは1例のみ受傷直後に高信号変化を伴う靱帯途絶所見があり、経時的に高信号を伴うびまん性膨化がみられた。CFLの幅は受傷直後7.2mm、4週後10.9mm、8週後11.5mmであった。尚、CFLに受傷直後の信号変化がなかった3例では、信号や幅は経時的に変化しなかった。以上より、3D-MRIは新鮮足関節外側靱帯損傷の診断と重症度判定、治療過程の評価に有用であることが示唆された。

人工膝関節置換術後の疼痛と術前大腿部筋断面積の関係　　　　　　　　　　　　　　　
赤塚 吉紘, 寺本 篤史, 高島 弘幸, 鈴木 智之, 岡田 葉平, 木井 雄一郎, 今村 塁, 渡邉 耕太, 山下 敏彦
日本整形外科学会雑誌, 90, 3, S782, S782, (公社)日本整形外科学会, Mar. 2016
Japanese

足関節外側靱帯損傷の3D MRI所見と治療選択　　　　　　　　　　　　　　　
寺本 篤史, 赤塚 吉紘, 高島 弘幸, 榊原 醸, 鈴木 智之, 渡邉 耕太, 山下 敏彦
日本整形外科学会雑誌, 90, 3, S945, S945, (公社)日本整形外科学会, Mar. 2016
Japanese

Participation/Dispatch Reports on International Conferences in 2016
Ikeda Shu, Shibukawa Shuhei, Takashima Hiroyuki
Japanese Journal of Radiological Technology, 72, 8, 708, 710, Japanese Society of Radiological Technology, 2016
Japanese

Evaluation of intramyocellular and extramyocellular lipids in the paraspinal muscle in patients with chronic low back pain using MR spectroscopy: preliminary results
Hiroyuki Takashima, Tsuneo Takebayashi, Izaya Ogon, Mitsunori Yoshimoto, Yoshinori Terashima, Rui Imamura, Toshihiko Yamashita
BRITISH JOURNAL OF RADIOLOGY, 89, 1064, 20160136, 20160136, BRITISH INST RADIOLOGY, 2016, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
English, Scientific journal, Objective: To analyze the intramyocellular lipids (IMCL) and extramyocellular lipids (EMCL) in the psoas muscle (Pm) and multifidus muscle (Mm) using MR spectroscopy (MRS) in patients with chronic low back pain (CLBP) and asymptomatic volunteers.
Methods: This prospective study had institutional review board approval, and written informed consent was obtained from all individual participants. 20 patients with CLBP (mean age, 49.8 +/- 12.5 years; age range, 28-66 years) with low back pain (LBP) duration of >= 3 months and asymptomatic volunteers (mean age, 44.0 +/- 12.8 years; age range, 28-65 years) underwent MRS for the quantification of IMCL and EMCL of the right Pm and Mm in a volume of interest at the intervertebral level of L4 through L5. We compared patients with CLBP and asymptomatic volunteers for age and body mass index (BMI), IMCL and EMCL of Pm and Mm. The Mann-Whitney U-test was used for significant difference testing, with p-value <0.05 indicating statistical significance.
Results: No statistically significant differences were observed in the age and BMI of patients with CLBP and asymptomatic volunteers. There was no statistically significant difference in the EMCL and IMCL in Pm between the two groups. EMCL in Mm was not statistically significantly different; the IMCL of patients with CLBP was significantly higher than that of asymptomatic volunteers (p < 0.05).
Conclusion: MRS demonstrates that IMCL in the Mm of patients with CLBP is significantly higher than that of asymptomatic volunteers. The increase of IMCL in the Mm may be a characteristic finding in CLBP.
Advances in knowledge: We investigated the detail of the fat content in the paraspinal muscles in patients CLBP and asymptomatic volunteers. The increase of fat content in the Mm of patients with LBP on previous studies was demonstrated to be the increase of IMCL.

MRI of Perfusion: Principles and Clinical Applications.
Nagahama H, Shonai T, Takashima H, Hirano T, Suzuki J, Sakurai Y
Igaku butsuri : Nihon Igaku Butsuri Gakkai kikanshi = Japanese journal of medical physics : an official journal of Japan Society of Medical Physics, 36, 2, 103, 109, 2016, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, The principle and clinical application of measurement of cerebral blood perfusion (CBP) using MRI are described. Purposes of measuring CBP using MRI are wide-ranging. Generally, it is used to diagnose cerebro-vascular disorders or brain tumors. There are two types of measuring methods. One is dynamic susceptibility contrast (DSC) method using a contrast agent as a tracer. Another is an arterial spin labeling (ASL) method using protons in arterial blood as an endogenous tracer, instead of bio-exogenous tracer. Basic theory of ASL method was published in the 1990s, recently, its clinical application has been spreading rapidly by the technological innovations. ASL method is attractive as a way to measure CBP because of its non-invasiveness (no radiation-exposure, not need intravenous injection or blood sampling), and the imaging time is about 5 minutes, thereby the measurement can be repeated. The analysis of DSC method has not been standardized, though various valuable parameters are provided. And the prerequisite of DSC method is uncertain in vivo. On the other hand, the result of ASL is affected by the post labeling delay, and limited to the arterial information.

Comparison with magnetic resonance three-dimensional sequence for lumbar nerve root with intervertebral foramen
Hiroyuki Takashima, Tsuneo Takebayashi, Hiroki Shishido, Mitsunori Yoshimoto, Rui Imamura, Yoshihiro Akatsuka, Yoshinori Terashima, Hiroyoshi Fujiwara, Masateru Nagae, Toshikazu Kubo, Toshihiko Yamashita
Asian Spine Journal, 10, 1, 59, 64, Korean Society of Spine Surgery, 2016, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
English, Scientific journal, Study Design: Prospective study based on magnetic resonance (MR) imaging of the lumbar spinal root of the intervertebral foramen. Purpose: This study was to compare MR three-dimensional (3D) sequences for the evaluation of the lumbar spinal root of the intervertebral foramen. Overview of Literature: The diagnosis of spinal disorders by MR imaging is commonly performed using two-dimensional T1-and T2-weighted images, whereas 3D MR images can be used for acquiring further detailed data using thin slices with multi-planar reconstruction. Methods: On twenty healthy volunteers, we investigated the contrast-to-noise ratio (CNR) of the lumbar spinal root of the intervertebral foramen with a 3D balanced sequence. The sequences used were the fast imaging employing steady state acquisition and the coherent oscillatory state acquisition for the manipulation of image contrast (COSMIC). COSMIC can be used with or without fat suppression (FS). We compared these sequence to determine the optimized visualization sequence for the lumbar spinal root of the intervertebral foramen. Results: For the CNR between the nerve root and the peripheral tissue, these were no significant differences between the sequences at the entry of foramen. There was a significant difference and the highest CNR was seen with COSMIC-FS for the intra- and extraforamen. Conclusions: In this study, the findings suggest that the COSMIC-FS sequences should be used for the internal or external foramen for spinal root disorders.

MRI拡散強調像を用いた腰椎椎間板ヘルニアにおける障害神経根の解析
高島 弘幸, 竹林 庸雄, 吉本 三徳, 寺島 嘉紀, 井田 和功, 今村 塁, 赤塚 吉紘, 山下 敏彦
北海道整形災害外科学会雑誌, 57, 1, 17, 22, 北海道整形災害外科学会, Dec. 2015, [Lead author, Corresponding author]
Japanese, 腰椎多椎間病変では、理学所見や神経根ブロックの効果により責任高位を同定しているが、客観性に乏しい側面を有する。神経根性疼痛の責任神経根では、神経根の炎症および浮腫性変化が起きる。これらは、MRI拡散強調像(diffusion weighted image:DWI)で評価が可能であると考えられ、障害神経レベルの拡散係数(apparent diffusion coefficient:ADC)が上昇することが報告されている。本研究の目的は、DWIを用いて、腰椎椎間板ヘルニアにおける障害レベルのDRGのADCを分析することである。単椎間の腰椎椎間板ヘルニア21例を解析した。障害神経根レベルのADCは患側で上昇が認められたのは12例、低下したのは9例であり、一定の傾向は認められなかった。ADCの患健側比と罹病期間、VASとに相関は認められなかった。一方、術前後のVASの改善率との関係では、患側のADCが低下した症例はVASの術後改善率が低い傾向であった。DWIのADCのみによる障害神経の判別は困難であると考えられるが、神経の可逆性に関連している可能性がある。(著者抄録)

無線型FPDの線量低減に関する検討 画像特性によるCRとの比較　　　　　　　　　　　　　　　
次木 嵩人, 佐藤 順一, 高島 弘幸, 宍戸 博紀, 今村 塁, 赤塚 吉紘, 赤石 泰一
北海道放射線技術雑誌, 79, 83, 83, (公社)日本放射線技術学会-北海道支部, Oct. 2015
Japanese

無線型FPDの線量低減に関する検討 人体ファントムによるCRとの比較　　　　　　　　　　　　　　　
早坂 駿, 佐藤 順一, 高島 弘幸, 宍戸 博紀, 今村 塁, 赤塚 吉紘, 赤石 泰一
北海道放射線技術雑誌, 79, 83, 83, (公社)日本放射線技術学会-北海道支部, Oct. 2015
Japanese

3D FIESTA-Cシーケンスを用いた足関節肢位による踵腓靱帯の評価　　　　　　　　　　　　　　　
赤塚 吉紘, 高島 弘幸, 宍戸 博記, 今村 塁, 柳田 美香, 寺本 篤史
北海道放射線技術雑誌, 79, 86, 86, (公社)日本放射線技術学会-北海道支部, Oct. 2015
Japanese

Mapping occipital bone thickness using computed tomography for safe screw placement
Tomonori Morita, Tsuneo Takebayashi, Hiroyuki Takashima, Mitsunori Yoshimoto, Kazunori Ida, Katsumasa Tanimoto, Hirofumi Ohnishi, Hiroyoshi Fujiwara, Masateru Nagae, Toshihiko Yamashita
JOURNAL OF NEUROSURGERY-SPINE, 23, 2, 254, 258, AMER ASSOC NEUROLOGICAL SURGEONS, Aug. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECT Safe and effective insertion of occipital bone screws requires morphological analysis of the occipital bone, which is poorly documented in the literature. The authors of this study present morphological data for determining the area of screw placement for optimal internal fixation.
METHODS The subjects of this institutional review board approved retrospective study were 105 individuals without head and neck disease who underwent CT imaging at the authors' hospital. There were 55 males and 50 females, with a mean age of 57.1 years (range 20-91 years). Measurements using CT were taken according to a matrix of 55 points following a grid with 1-cm spacing based on the external occipital protuberance (EOP).
RESULTS The maximum thickness of the occipital bone was at the level of the EOP at 16.4 mm. Areas with thicknesses > 8 mm were more frequent at the EOP and up to 2 cm in all directions, as well as up to 1 cm in all directions at a height of 1 cm inferiorly, and up to 3 cm from the EOP inferiorly. The male group tended to have a thicker occipital bone than the female group, and the differences were significant around the EOP. The ratio of the trabecular bone to the occipital bone thickness was > 30% in the central region. At positions more than 2 cm laterally, the ratio was < 15%, and the ratio gradually decreased further laterally.
CONCLUSIONS Screws that are 8 mm long can be placed in the area extending 2 cm laterally from the EOP at the level of the superior nuchal line and approximately 3 cm inferior to the center. These results suggest that it may be possible to effectively insert a screw over a wider area than the conventional reference range.

Effect of ankle flexion on the quantification of MRS for intramyocellular lipids of the tibialis anterior and the medial gastrocnemius
Hiroyuki Takashima, Hiroki Shishido, Rui Imamura, Yoshihiro Akatsuka, Keigo Taniguchi, Mitsuhiro Nakanishi, Junpei Suzuki, Hiroshi Nagahama, Yuki Sakurai, Motomichi Sakata
Radiological Physics and Technology, 8, 2, 209, 214, Springer-Verlag Tokyo, 23 Jul. 2015, [Peer-reviewed], [Lead author, Corresponding author], [Domestic magazines]
English, Scientific journal, Muscle proton magnetic resonance spectroscopy (MRS) has been developed for non-invasive measurement of intramyocellular lipid (IMCL) levels. The majority of previous studies measuring IMCL with MRS have been performed on the calf muscle. The appearance of muscle MRS is influenced by bulk magnetic susceptibility and residual dipolar couplings, which depend on the angle between the muscle fibers and the main magnetic field. Our objective in this study was to evaluate the effect of ankle flexion and of the pennation angle on IMCL quantification in the calf muscle using proton MRS. The subjects comprised ten healthy male volunteers. In proton MRS, the ankle flexion angle was changed, and the pennation angle was measured from the tibialis anterior (TA) and the medial gastrocnemius (MG), respectively. We considered the relationship between the quantification of IMCL with 1H MRS and the pennation angle by ankle flexion angle. The pennation angle of the TA and MG changed with the ankle flexion angle. The IMCL on the TA decreased significantly with plantar flexion (p <
 0.05). However, the IMCL on the MG demonstrated no significant difference. The MR spectrum and IMCL quantitation changed with the pennation angle. Therefore, when spectra of individual subjects in longitudinal studies or between subjects are compared in cross-sectional studies, the foot position or calf muscle orientation must be considered.

MRI 3Dシーケンスによる足関節外側靱帯の評価
赤塚 吉紘, 高島 弘幸, 宍戸 博紀, 今村 塁, 寺本 篤史, 渡邉 耕太, 山下 敏彦
北海道整形災害外科学会雑誌, 56, 2, 305, 306, 北海道整形災害外科学会, Jul. 2015
Japanese

World Report 国際学会に参加して : RSNA 2014
高島 弘幸
JART = 日本診療放射線技師会誌, 62, 6, 551, 553, 日本診療放射線技師会, Jun. 2015
Japanese

Analysis of chronic low back pain with magnetic resonance imaging T2 mapping of lumbar intervertebral disc
Izaya Ogon, Tsuneo Takebayashi, Hiroyuki Takashima, Katsumasa Tanimoto, Kazunori Ida, Mitsunori Yoshimoto, Hiroyoshi Fujiwara, Toshikazu Kubo, Toshihiko Yamashita
JOURNAL OF ORTHOPAEDIC SCIENCE, 20, 2, 295, 301, SPRINGER JAPAN KK, Mar. 2015, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Magnetic resonance imaging (MRI) T2 mapping utilizes the T2 values for quantification of moisture content and collagen sequence breakdown. Recently, attempts at quantification of lumbar disc degeneration through MRI T2 mapping have been reported. We conducted an analysis of the relationship between T2 values of degenerated intervertebral discs (IVD) and chronic low back pain (CLBP).
The subjects who had CLBP comprised 28 patients (15 male, 13 female; mean age 48.9 +/- A 9.6 years; range 22-60 years). All subjects underwent MRI and filled out the low back pain visual analog scale (VAS) and Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ). The disc was divided into the anterior annulus fibrosus (AF), the nucleus pulposus (NP), and the posterior AF, and each T2 value was measured. This study involved 25 asymptomatic control participants matched with the CLBP group subjects for gender and age (13 male, 12 female; mean age 43.8 +/- A 14.5 years; range 23-60 years). These subjects had no low back pain, and constituted the control group.
T2 values for IVD tended to be lower in the CLBP group than in the control group, and these values were significantly different within the posterior AF. The correlation coefficients between the VAS scores and T2 values of anterior AF, NP and posterior AF were r = 0.30, -0.15 and -0.50. The correlation coefficient between the JOABPEQ scores (low back pain) and T2 values of anterior AF, NP and posterior AF were r = -0.0041, 0.11 and 0.42. Similarly, the JOABPEQ scores (lumbar function) were r = -0.22, -0.12 and 0.57.
The results indicated a correlation between posterior AF degeneration and CLBP. This study suggests that MRI T2 mapping could be used as a quantitative method for diagnosing discogenic pain.

Visualization of the foramen intervertebral nerve root of cervical spine with 3.0 tesla magnetic resonance imaging: a comparison of three-dimensional acquisition techniques.
Shishido H, Takashima H, Takebayashi T, Akatsuka Y, Imamura R, Nagahama H, Shirase R
Nihon Hoshasen Gijutsu Gakkai zasshi, 70, 7, 670, 675, 7, Jul. 2014, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, Identification of the compression factor in cervical disc herniation and cervical spondylotic radioculopathy is often problematic when using two-dimensional magnetic resonance imaging (MRI). This prompted us to compare and examined three-dimensional sequences, coherent oscillatory state acquisition for the manipulation of image contrast (COSMIC), fast imaging employing steady state acquisition (FIESTA) and T2 star weighted MR angiography (SWAN) with 3.0-Tesla (T) MRI to visualize the foramen intervertebral nerve root for the cervical spine. Fat-suppressed COSMIC (FS-COSMIC) sequence gave the highest signal intensity ratio (1.85 ± 0.06) of the nerve root and vertebral arch. A significant difference in signal intensity ratio of the nerve root was found between FS-COSMIC and FIESTA sequences. No significant difference was found between the FS-COSMIC and FIESTA sequences in the cerebrospinal fluid and the spinal cord. The FS-COSMIC sequence proved to be the most suitable sequence for intra and extra dura matter.

Investigation of Intervertebral Disc and Facet Joint in Lumbar Spondylolisthesis using T-2 Mapping
Hiroyuki Takashima, Tsuneo Takebayashi, Mitsunori Yoshimoto, Yoshinori Terashima, Kazunori Ida, Hiroki Shishido, Rui Imamura, Yoshihiro Akatsuka, Ryuji Shirase, Hiroyoshi Fujiwara, Toshikazu Kubo, Toshihiko Yamashita
MAGNETIC RESONANCE IN MEDICAL SCIENCES, 13, 4, 261, 266, JPN SOC MAGNETIC RESONANCE IN MEDICINE, 2014, [Peer-reviewed], [Lead author], [Domestic magazines]
English, Scientific journal, Purpose: We measured T-2 relaxation time of the intervertebral discs (IVD) and facet joints (FJ) in patients with degenerative spondylolisthesis (DS) and no spondylolisthesis (NS) and investigated the characteristics of these parts in DS.
Methods: In 40 patients with DS and 40 patients with NS, we measured T-2 relaxation time of the IVD and FJ and compared them between groups. In the group with DS, we also examined the relationship between the degree of slippage using Meyerding grade and T-2 relaxation of each part in the IVD and FJ.
Results: T-2 relaxation time of the IVD tended to be lower in the DS than NS group and differed significantly (P < 0.01) within the anterior annulus fibrosus. T-2 relaxation time in the FJ was significantly higher in the DS than NS group. T-2 relaxation time in the FJ was significantly higher for those assessed Meyerding Grade II than Grade I, although we observed no significant differences in T-2 relaxation time in any area of the IVD.
Conclusion: T-2 relaxation time decreased in the anterior annulus fibrosus of the IVD and increased in the FJ in patients with DS, suggesting an association of IVD and FJ degeneration with the development of lumbar DS.

Subtalar Joint Stress Imaging With Tomosynthesis
Atsushi Teramoto, Kota Watanabe, Hiroyuki Takashima, Toshihiko Yamashita
Foot and Ankle Specialist, 7, 3, 181, 183, SAGE Publications Ltd, 2014, [Peer-reviewed], [International Magazine]
English, Scientific journal, The purpose of this study was to perform stress imaging of hindfoot inversion and eversion using tomosynthesis and to assess the subtalar joint range of motion (ROM) of healthy subjects. The subjects were 15 healthy volunteers with a mean age of 29.1 years. Coronal tomosynthesis stress imaging of the subtalar joint was performed in a total of 30 left and right ankles. A Telos stress device was used for the stress load, and the load was 150 N for both inversion and eversion. Tomographic images in which the posterior talocalcaneal joint could be confirmed on the neutral position images were used in measurements. The angle of the intersection formed by a line through the lateral articular facet of the posterior talocalcaneal joint and a line through the surface of the trochlea of the talus was measured. The mean change in the angle of the calcaneus with respect to the talus was 10.3 ± 4.8° with inversion stress and 5.0 ± 3.8° with eversion stress from the neutral position. The result was a clearer depiction of the subtalar joint, and inversion and eversion ROM of the subtalar joint was shown to be about 15° in healthy subjects.Levels of Evidence: Diagnostic, Level IV © 2014 The Author(s).

[Analysis of diffusion tensor for cervical spinal cord using 3 tesla MRI].
Takashima H
Nihon Hoshasen Gijutsu Gakkai zasshi, 69, 11, 1292, 1296, 11, Nov. 2013, [Peer-reviewed], [Lead author, Corresponding author], [Domestic magazines]
Japanese

トモシンセシスによる距骨下関節ストレス撮影
寺本 篤史, 渡邉 耕太, 小林 拓馬, 山下 敏彦, 高島 弘幸, 赤塚 吉紘
北海道整形災害外科学会雑誌, 55, 1, 105, 105, 北海道整形災害外科学会, Aug. 2013
Japanese

Efficacy of Diffusion-Weighted Magnetic Resonance Imaging in Diagnosing Spinal Root Disorders in Lumbar Disc Herniation
Hiroyuki Takashima, Tsuneo Takebayashi, Mitsunori Yoshimoto, Yoshinori Terashima, Kazunori Ida, Toshihiko Yamashita
SPINE, 38, 16, E998, E1002, LIPPINCOTT WILLIAMS & WILKINS, Jul. 2013, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal, Study Design. Prospective study based on magnetic resonance imaging for lumbar disc herniation.
Objective. In this study, we captured diffusion-weighted imaging (DWI) of dorsal root ganglion (DRG) of the affected nerve root in lumbar disc herniation and examined the relationship between apparent diffusion coeffi cient (ADC) and clinical symptoms to evaluate the effi cacy of DWI in the diagnosis of lumbar spinal disorders.
Summary of Background Data. DWI captures diffusion of water molecules in intracellular or extracellular fl uid, allowing visualization of edematous changes, and is therefore used in diagnosis of hyper-acute cerebral infarction. In addition, it is possible to quantify the degree of diffusion using ADC calculated from the DWI data. Meanwhile in lumbar disc herniation, edematous changes occur in DRG of affected nerve root. If DWI enables visualization of these edematous changes, it will be possible to diagnose objectively the affected level.
Methods. The subjects were 30 patients who underwent surgery of unilateral radiculopathy and a single level lumbar disc herniation. We analyzed the relationship between morbidity duration, visual analogue scale (VAS) score of leg symptoms, and ADC. In addition, we investigated any correlation between VAS recovery ratio (i.e., VAS preoperative -VAS postoperative)/VAS preoperative x 100) with ADC.
Results. When compared with the contralateral side, ADC of the affected DRG was observed to increase in 18 and decrease in 12 subjects, and thus no defi nite trend was observed. The relationship between morbidity duration, VAS score, and ADC had no observed correlation. A positive correlation between ADC and VAS recovery ratio was statistically observed (P < 0.01, leg pain: r = 0.707, leg numbness: r = 0.738).
Conclusion. This study showed that patients with decreased ADC tended to show poor improvement of leg symptoms, which may suggest the possibility that ADC of DRG is related to neuronal plasticity.

Differences in Tibiotalar Joint Alignment During Non-loaded and Axial Loaded Condition in Intact Male Feet
Nozaki Shuhei, Taniguchi Keigo, Takashima Hiroyuki, Watanabe Kota, Hatakenaka Masamitsu, Katayose Masaki
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 45, 5, 55, 56, LIPPINCOTT WILLIAMS & WILKINS, May 2013, [Peer-reviewed]
English, International conference proceedings

[Optimized magnetic resonance sequences and parameters with operative assisted images for radical prostatectomy at 3 tesla-magnetic resonance image].
Shirase R, Sakurai Y, Nagahama H, Harada K, Takashima H, Nakanishi M, Harada K, Shishido H, Imamura R, Sakata M, Hatakenaka M
Nihon Hoshasen Gijutsu Gakkai zasshi, 69, 5, 529, 534, 5, May 2013, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, The objective of our study was to optimize magnetic resonance image (MRI) sequences and parameters using operative assisted images (three-dimensional images) for radical prostatectomy at 3 tesla (T) MRI. Five healthy volunteers underwent MRI on the 3.0 T scanner. Various sequences and parameters [Cube (TE/TR = 18, 50, 90 ms/2000 ms), FIESTA (TE/TR/FA = 2.4 ms/5 ms/40 degrees, 90 degrees), fSPGR (TE/TR/FA = 2.3 ms/11.2 ms/20 degrees), slice thickness = 1.2 mm, matrix = 192 x 160] were respectively compared. Several structures of the pelvis (the central zones and transition zones of the prostate, the peripheral zones of the prostate, seminal vesicles, rectum wall, bladder, muscle and fat) were determined. The signal intensities of these structures were measured on reformatted axial images and compared against several structures of the pelvis. Correlation with various sequences and parameters was based on the signal-to-noise ratio (SNR), the contrast ratio (CR) and the presence of artifacts. Student's t-test was used for statistical analysis. With Cube (TE/TR = 50 ms/2000 ms), the average value of visual evaluation with artifacts was high, and SNR and CR were higher than for other sequence and parameters. Optimized MRI sequences and parameters were Cube (TE/TR = 50 ms/2000 ms) which provides improved SNR and CR and the presence of artifacts with operative assisted images for radical prostatectomy. These operative assisted images obtained from Cube (TE/TR = 50 ms/2000 ms) are likely to be useful for surgery.

人工膝関節大腿骨コンポーネント回旋設置評価におけるトモシンセシスの有用性
寺本 篤史, 小路 弘晃, 渡邉 耕太, 佐藤 直一, 木井 雄一郎, 工藤 未来, 大坪 英則, 山下 敏彦, 高島 弘幸
北海道整形災害外科学会雑誌, 54, 2, 322, 322, 北海道整形災害外科学会, Mar. 2013
Japanese

トモシンセシスを用いた遠位脛腓靱帯結合荷重撮影
寺本 篤史, 渡邉 耕太, 木井 雄一郎, 小林 拓馬, 山下 敏彦, 高島 弘幸
北海道整形災害外科学会雑誌, 54, 2, 329, 329, 北海道整形災害外科学会, Mar. 2013
Japanese

Correlation between T2 relaxation time and intervertebral disk degeneration
Hiroyuki Takashima, Tsuneo Takebayashi, Mitsunori Yoshimoto, Yoshinori Terashima, Hajime Tsuda, Kazunori Ida, Toshihiko Yamashita
SKELETAL RADIOLOGY, 41, 2, 163, 167, SPRINGER, Feb. 2012, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal, Magnetic resonance T2 mapping allows for the quantification of water and proteoglycan content within tissues and can be used to detect early cartilage abnormalities as well as to track the response to therapy. The goal of the present study was to use T2 mapping to quantify intervertebral disk water content according to the Pfirrmann classification.
This study involved 60 subjects who underwent lumbar magnetic resonance imaging (a total of 300 lumbar disks). The degree of disk degeneration was assessed in the midsagittal section on T2-weighted images according to the Pfirrmann classification (grades I to V). Receiver operating characteristic (ROC) analysis was performed among grades to determine the cut-off values.
In the nucleus pulposus, T2 values tended to decrease with increasing grade, and there was a significant difference in T2 values between each grade from grades I to IV. However, there was no significant difference in T2 values in the anterior or posterior annulus fibrosus. T2 values according to disk degeneration level classification were as follows: grade I (> 116.8 ms), grade II (92.7-116.7 ms), grade III (72.1-92.6 ms), grade IV (< 72.0 ms).
T2 values decreased with increasing Pfirrmann classification grade in the nucleus pulposus, likely reflecting a decrease in proteoglycan and water content. Thus, T2 value-based measurements of intervertebral disk water content may be useful for future clinical research on degenerative disk diseases.

Vocabulary MRI拡散強調画像
高島 弘幸
整形外科, 60, 3, 254, 254, 南江堂, 01 Mar. 2009, [Lead author, Corresponding author]
Japanese

蛍光塗料を用いた模擬感染症患者におけるCT検査時の感染箇所の同定と清拭効果—Evaluation of the region of contact infection and wiping during CT in patients with simulated infections—論文特集号
小倉 圭史, 小野 志穂, 大橋 芳也, 中西 光広, 浅沼 治, 高島 弘幸, JART = 日本診療放射線技師会誌, 70, 6, 604, 608, May 2023
東京 : 日本診療放射線技師会, Japanese

MRI intra-voxel incoherent motionを用いた骨粗鬆症性椎体骨折の予後予測
黄金 勲矢, 竹林 庸雄, 高島 弘幸, 阿部 恭久, 小熊 大士, 塚本 有彦, 廣田 亮介, 森田 智慶, 家里 典幸, 吉本 三徳, 山下 敏彦, 日本整形外科学会雑誌, 97, 3, S786, S786, Mar. 2023
(公社)日本整形外科学会, Japanese

内臓脂肪は中枢性感作を介して慢性腰痛に関与する
黄金 勲矢, 高島 弘幸, 塚本 有彦, 千葉 充将, 廣田 亮介, 森田 智慶, 家里 典幸, 吉本 三徳, 竹林 庸雄, 山下 敏彦, 日本整形外科学会雑誌, 97, 3, S919, S919, Mar. 2023
(公社)日本整形外科学会, Japanese

慢性腰痛と内臓脂肪および中枢性感作の関連
黄金 勲矢, 高島 弘幸, 吉本 三徳, 竹林 庸雄, 山下 敏彦, PAIN RESEARCH, 37, 4, 264, 264, Dec. 2022
(一社)日本疼痛学会, Japanese

慢性腰痛と内臓脂肪および中枢性感作の関連
黄金 勲矢, 高島 弘幸, 吉本 三徳, 竹林 庸雄, 山下 敏彦, Journal of Musculoskeletal Pain Research, 14, 4, S52, S52, Oct. 2022
(一社)日本運動器疼痛学会, Japanese

びまん性特発性骨増殖症罹患と血管石灰化・心血管イベント発症の関連性
廣田 亮介, 吉本 三徳, 高島 弘幸, 安田 尚美, 川原田 修義, 山下 敏彦, 東日本整形災害外科学会雑誌, 34, 3, 249, 249, Aug. 2022
東日本整形災害外科学会, Japanese

腰椎椎間板ヘルニアに対する椎間板内酵素注入療法での椎間板髄核と軟骨終板、椎間板高の変化 UTE法を用いた解析
塚本 有彦, 吉本 三徳, 高島 弘幸, 押切 勉, 大山 智充, 廣田 亮介, 黄金 勲矢, 家里 典幸, 射場 浩介, 山下 敏彦, 日本整形外科学会雑誌, 96, 2, S57, S57, Mar. 2022
(公社)日本整形外科学会, Japanese

腰椎椎間板ヘルニアに対する椎間板内酵素注入療法はどのような症例が早期改善するか MRI ultra-short TE法を用いた定量的解析
塚本 有彦, 吉本 三徳, 押切 勉, 高島 弘幸, 大山 智充, 廣田 亮介, 黄金 勲矢, 家里 典幸, 射場 浩介, 山下 敏彦, 日本整形外科学会雑誌, 96, 2, S195, S195, Mar. 2022
(公社)日本整形外科学会, Japanese

びまん性特発性骨増殖症罹患と血管石灰化・心血管イベント発症の関連性
廣田 亮介, 高島 弘幸, 塚本 有彦, 黄金 勲矢, 家里 典幸, 吉本 三徳, 山下 敏彦, 日本整形外科学会雑誌, 96, 2, S210, S210, Mar. 2022
(公社)日本整形外科学会, Japanese

腰部脊柱管狭窄症における腰痛に対する除圧術の成績 腰痛と腰椎前彎角の関連
黄金 勲矢, 高島 弘幸, 塚本 有彦, 千葉 充将, 廣田 亮介, 家里 典幸, 吉本 三徳, 山下 敏彦, 日本整形外科学会雑誌, 96, 3, S765, S765, Mar. 2022
(公社)日本整形外科学会, Japanese

MRIで定量的に評価した腰椎椎間板変性と椎間可動性の関連
黄金 勲矢, 高島 弘幸, 塚本 有彦, 千葉 充将, 廣田 亮介, 家里 典幸, 吉本 三徳, 山下 敏彦, 日本整形外科学会雑誌, 96, 3, S1104, S1104, Mar. 2022
(公社)日本整形外科学会, Japanese

腰椎椎体終板変性と骨強度の関連 Ultra-short TEとtrabecular bone scoreを用いた解析
黄金 勲矢, 高島 弘幸, 塚本 有彦, 千葉 充将, 廣田 亮介, 家里 典幸, 吉本 三徳, 山下 敏彦, 日本整形外科学会雑誌, 96, 3, S1105, S1105, Mar. 2022
(公社)日本整形外科学会, Japanese

MRI ultra-short TE法を用いた椎間板髄核と軟骨終板の定量的評価
塚本 有彦, 高島 弘幸, 吉本 三徳, 大山 智充, 廣田 亮介, 押切 勉, 黄金 勲矢, 家里 典幸, 射場 浩介, 山下 敏彦, 日本整形外科学会雑誌, 96, 3, S1105, S1105, Mar. 2022
(公社)日本整形外科学会, Japanese

慢性腰痛に対する肥満と骨粗鬆症の影響
黄金 勲矢, 高島 弘幸, 塚本 有彦, 千葉 充将, 廣田 亮介, 家里 典幸, 吉本 三徳, 山下 敏彦, 日本整形外科学会雑誌, 96, 3, S1108, S1108, Mar. 2022
(公社)日本整形外科学会, Japanese

腰椎椎間板ヘルニアに対する椎間板内酵素注入療法はどのような症例が早期改善するか MRI ultra-short TE法を用いた定量的解析　　　　　　　　　　　　　　　
塚本 有彦, 押切 勉, 吉本 三徳, 高島 弘幸, 大山 智充, 廣田 亮介, 黄金 勲矢, 家里 典幸, 射場 浩介, 山下 敏彦, Journal of Spine Research, 13, 3, 198, 198, Mar. 2022
(一社)日本脊椎脊髄病学会, Japanese

MRI ultra-short TE法を用いた椎間板髄核と軟骨終板の定量的評価　　　　　　　　　　　　　　　
塚本 有彦, 高島 弘幸, 吉本 三徳, 大山 智充, 廣田 亮介, 黄金 勲矢, 家里 典幸, 射場 浩介, 山下 敏彦, Journal of Spine Research, 13, 3, 213, 213, Mar. 2022
(一社)日本脊椎脊髄病学会, Japanese

びまん性特発性骨増殖症罹患と血管石灰化・心血管イベント発症の関連性　　　　　　　　　　　　　　　
廣田 亮介, 吉本 三徳, 高島 弘幸, 塚本 有彦, 黄金 勲矢, 家里 典幸, 山下 敏彦, Journal of Spine Research, 13, 3, 230, 230, Mar. 2022
(一社)日本脊椎脊髄病学会, Japanese

定量的画像解析法を用いた骨粗鬆性椎体骨折の予後予測 MRI intra-voxel incoherent motionによる解析
高島 弘幸, 竹林 庸雄, 阿部 恭久, 小熊 大士, 黄金 勲矢, 今村 塁, 赤塚 吉紘, 山下 敏彦, Journal of Musculoskeletal Pain Research, 13, 4, S58, S58, Oct. 2021
(一社)日本運動器疼痛学会, Japanese

MRI ultra-short TEで評価した椎体終板変性と脊柱・骨盤アライメントの関連
黄金 勲矢, 高島 弘幸, 寺島 嘉紀, 吉本 三徳, 山下 敏彦, Journal of Musculoskeletal Pain Research, 13, 4, S58, S58, Oct. 2021
(一社)日本運動器疼痛学会, Japanese

腰椎椎間板ヘルニアに対する椎間板内酵素注入療法による椎間板の画像的変化 MRI ultra-short TEを用いた定量的解析
黄金 勲矢, 押切 勉, 高島 弘幸, 塚本 有彦, 寺島 嘉紀, 吉本 三徳, 山下 敏彦, Journal of Musculoskeletal Pain Research, 13, 4, S61, S61, Oct. 2021
(一社)日本運動器疼痛学会, Japanese

圧縮センシング併用3D MRIにおけるCS factorが空間分解能に与える影響　　　　　　　　　　　　　　　
植村 美穂, 中西 光広, 赤塚 吉紘, 今村 塁, 長濱 宏史, 沼澤 香夏子, 高島 弘幸, 北海道放射線技術雑誌, 91, 55, 55, Oct. 2021
(公社)日本放射線技術学会-北海道支部, Japanese

呼吸同期の有無による圧縮センシング併用4D Flow MRIの撮像時間および大動脈血流定量値の比較　　　　　　　　　　　　　　　
沼澤 香夏子, 中西 光広, 赤塚 吉紘, 今村 塁, 植村 美穂, 鈴木 瑞穂, 高島 弘幸, 北海道放射線技術雑誌, 91, 58, 58, Oct. 2021
(公社)日本放射線技術学会-北海道支部, Japanese

胸骨骨折否定目的で行ったMRIで肋軟骨損傷と診断された1例　　　　　　　　　　　　　　　
赤塚 吉紘, 中西 光広, 植村 美穂, 今村 塁, 早川 耕平, 高島 弘幸, 北海道放射線技術雑誌, 91, 59, 59, Oct. 2021
(公社)日本放射線技術学会-北海道支部, Japanese

びまん性特発性骨増殖症罹患と血管石灰化・心血管イベント発症の関連性
廣田 亮介, 吉本 三徳, 高島 弘幸, 塚本 有彦, 黄金 勲矢, 家里 典幸, 山下 敏彦, 東日本整形災害外科学会雑誌, 33, 3, 321, 321, Aug. 2021
東日本整形災害外科学会, Japanese

脱分化脂肪肉腫における脂肪成分領域割合は予後を予測できる
清水 淳也, 江森 誠人, 高島 弘幸, 村橋 靖崇, 土江 博幸, 永澤 博幸, 宮腰 尚久, 島田 洋一, 山下 敏彦, 東日本整形災害外科学会雑誌, 33, 3, 381, 381, Aug. 2021
東日本整形災害外科学会, Japanese

腰椎椎間板ヘルニアに対するコンドリアーゼ治療による椎間板の画像的変化
押切 勉, 黄金 勲矢, 高島 弘幸, 家里 典幸, 吉本 三徳, 山下 敏彦, 東日本整形災害外科学会雑誌, 33, 3, 399, 399, Aug. 2021
東日本整形災害外科学会, Japanese

脊髄神経鞘腫と髄膜腫の単純MRIを用いた鑑別法の検討
藤本 秀太郎, 寺島 嘉紀, 高島 弘幸, 板橋 尚秀, 廣田 亮介, 押切 勉, 黄金 勲矢, 家里 典幸, 吉本 三徳, 園田 智子, 山下 敏彦, 東日本整形災害外科学会雑誌, 33, 3, 417, 417, Aug. 2021
東日本整形災害外科学会, Japanese

寛骨臼回転骨切術における適切な寛骨臼の回転方向
鈴木 大輔, 名越 智, 金泉 新, 喜澤 史弥, 高島 弘幸, 舘田 健児, 小助川 維摩, 山下 敏彦, 日本整形外科学会雑誌, 95, 8, S1650, S1650, Aug. 2021
(公社)日本整形外科学会, Japanese

びまん性特発性骨増殖症(DISH)罹患と血管石灰化・心血管イベント発症の関連性
廣田 亮介, 吉本 三徳, 高島 弘幸, 塚本 有彦, 黄金 勲矢, 家里 典幸, 山下 敏彦, 日本整形外科学会雑誌, 95, 8, S1789, S1789, Aug. 2021
(公社)日本整形外科学会, Japanese

尾部懸垂モデルラットは筋細胞内脂肪(IMCL)の変化を反映するモデルとして使用できるか
高島 弘幸, 黄金 勲矢, 寺島 嘉紀, 射場 浩介, 吉本 三徳, 山下 敏彦, 日本整形外科学会雑誌, 95, 8, S1827, S1827, Aug. 2021
(公社)日本整形外科学会, Japanese

圧縮センシング MRIによる高速化が3D-TSE画像の解像度に与える影響　　　　　　　　　　　　　　　
今村 塁, 高島 弘幸, 中西 光広, 長濱 宏史, 赤塚 吉紘, 北海道放射線技術雑誌, 87, 56, 56, Oct. 2019
(公社)日本放射線技術学会-北海道支部, Japanese

脳の圧縮センシングMRI 三次元等方性ボクセルスピンエコーの撮像時間は半減する　　　　　　　　　　　　　　　
長濱 宏史, 今村 塁, 赤塚 吉紘, 中西 光広, 高島 弘幸, 北海道放射線技術雑誌, 87, 66, 66, Oct. 2019
(公社)日本放射線技術学会-北海道支部, Japanese

APT-CESTにおける卵白粉を用いたpHイメージングの基礎検討　　　　　　　　　　　　　　　
赤塚 吉紘, 高島 弘幸, 今村 塁, 長濱 宏史, 中西 光広, 北海道放射線技術雑誌, 87, 67, 67, Oct. 2019
(公社)日本放射線技術学会-北海道支部, Japanese

高速スピンエコー拡散強調像(TSE-DWI)におけるcompressed sensing factorの検討　　　　　　　　　　　　　　　
高島 弘幸, 中西 光広, 長濱 宏史, 今村 塁, 赤塚 吉紘, 北海道放射線技術雑誌, 87, 68, 68, Oct. 2019
(公社)日本放射線技術学会-北海道支部, Japanese

圧縮センシングMRIは心筋T1mappingの空間分解能向上に貢献できるか　　　　　　　　　　　　　　　
中西 光広, 赤塚 吉紘, 今村 塁, 長濱 宏史, 高島 弘幸, 北海道放射線技術雑誌, 87, 69, 69, Oct. 2019
(公社)日本放射線技術学会-北海道支部, Japanese

脱分化脂肪肉腫における脂肪成分領域割合は予後を予測できる
清水 淳也, 江森 誠人, 高島 弘幸, 土江 博幸, 村橋 靖崇, 水島 衣美, 山下 敏彦, 日本整形外科学会雑誌, 93, 6, S1438, S1438, Jun. 2019
(公社)日本整形外科学会, Japanese

脱分化脂肪肉腫における脂肪成分領域割合は予後を予測できる
清水 淳也, 山下 敏彦, 江森 誠人, 村橋 靖崇, 水島 衣美, 高島 弘幸, 土江 博幸, 北海道整形災害外科学会雑誌, 61, 136th suppl, 3, 3, 2019
北海道整形災害外科学会, Japanese

Aerial surveying and geometric analysis of columnar joint using Drone
Akiba Yuri, Takashima Aika, Shima Hiroyuki, PROGRAMME AND ABSTRACTS THE VOLCANOLOGICAL SOCIETY OF JAPAN, 2019, 133, 133, 2019
The Volcanological Society of Japan, Japanese

外傷性頸部症候群における頸部多裂筋脂肪変性のMRI評価　　　　　　　　　　　　　　　
竹林 庸雄, 阿部 恭久, 小熊 大士, 三木 貴弘, 盛 智子, 吉中 亘康, 高島 弘幸, 山下 敏彦, 日本整形外科学会雑誌, 92, 3, S1072, S1072, Mar. 2018
(公社)日本整形外科学会, Japanese

MRI depiction of three ACL bundles
赤塚 吉紘, 大坪 英則, 高島 弘幸, 鈴木 智之, 山下 敏彦, 史野 根生, 整形・災害外科, 59, 11, 1533, 1537, Oct. 2016
正常膝前十字靱帯(ACL)は前内側線維束内側部(AM-M束)、前内側線維束外側部(AM-L束)、後外側線維束(PL束)の3線維束に分けられる。今回、3T-MRIを用いてヒト生体ACLの3線維束の描出を試みた。健常ボランティア24名(男性15名、女性9名)の膝を3T-MRI装置にてFS 3D-COSMIC シーケンスで撮像した。次いで、ACLの各線維束を描出するため0.6mmの等方性ボクセルデータを取得し、撮像後に画像再構成して最適断面を決定した。その結果、ACLの3線維束はACL中央1/3の脛骨側での斜位横断面で最も良好に描出された。全例でAM-M束とAM-L束は明確に描出されたが、2膝(8%)ではPL束の描出は不鮮明であった。以上より、3T-MRI装置を用いてFS 3D-COSMICの等方性ボクセルデータを取得することでACLの3線維束の確実な描出が可能となった。, 金原出版, Japanese

【脳を対象にした機能的MR検査特集】MRIによる灌流計測の原理と臨床応用
長濱 宏史, 庄内 孝春, 高島 弘幸, 平野 透, 鈴木 淳平, 櫻井 佑樹, 医学物理, 36, 2, 103, 109, Aug. 2016
(公社)日本医学物理学会, Japanese

Microendoscopic Muscle-preserving Interlaminar Decompression for Lumbar Spinal Stenosis : Association between Low Back Pain and Lumbar Lordosis
黄金 勲矢, 竹林 庸雄, 吉本 三徳, 高島 弘幸, 嘉野 真允, 寺島 嘉紀, 山下 敏彦, Journal of spine research : official journal of the Japanese Society for Spine Surgery and Related Research, 7, 6, 992, 996, Jun. 2016
腰部脊柱管狭窄症61例(男性44例、女性17例、平均年齢72.0±1.0歳)に内視鏡下単独除圧術を施行し、腰痛と腰椎前彎角の関連を検討した。腰痛visual analog scaleの平均は術前54.5mmが術後20.8mmに減少した。腰椎前彎角の平均は術前35.8°が術後41.1°に増加した。腰痛の改善と腰椎前彎角の増加には有意な相関を認め、本術式により腰痛および腰椎アライメントが改善する可能性が示唆された。(著者抄録), 日本脊椎脊髄病学会, Japanese

3Dシーケンスを用いた腰部椎間孔部の画像評価
高島 弘幸, 竹林 庸雄, 吉本 三徳, 今村 塁, 赤塚 吉紘, 井田 和功, 寺島 嘉紀, 谷本 勝正, 山下 敏彦, 北海道整形災害外科学会雑誌 : 北海道整形災害外科学会機関誌, 57, 2, 252, 256, Apr. 2016
北海道整形災害外科学会, Japanese

3次元尖度コントラスト(3DKC)(Three-dimensional kurtosis contrast(3DKC))　　　　　　　　　　　　　　　
長濱 宏史, 片桐 好美, 櫻井 佑樹, 鈴木 淳平, 中西 光広, 高島 弘幸, 北海道放射線技術雑誌, 80, 6, 7, Apr. 2016
(公社)日本放射線技術学会-北海道支部, Japanese

腰椎椎間板におけるTSL(time of spin lock)の設定とT1rho値の関係　　　　　　　　　　　　　　　
今村 累, 高島 弘幸, 奥秋 知幸, 中西 光広, 長濱 宏史, 宍戸 博紀, 赤塚 吉紘, 北海道放射線技術雑誌, 80, 46, 47, Apr. 2016
(公社)日本放射線技術学会-北海道支部, Japanese

Association of low back pain and fat content of paraspinal muscle using MR spectroscopy
Takashima Hiroyuki, Takebayashi Tsuneo, Ogon Izaya, Yoshimoto Mitsunori, Terashima Yoshinori, Imamura Rui, Kano Masanobu, Nakanishi Mitsuhiro, Nagahama Hiroshi, Yamashita Toshihiko, PAIN RESEARCH, 30, 4, 230, 237, Dec. 2015, [Lead author, Corresponding author]
Objective. To analyze the intramyocellular lipids (IMCL) and extramyo cellular lipids (EMCL) in the multifidus muscle (Mm) using magnetic resonance spectroscopy (MRS) with chronic low back pain (LBP) patients and to identify possible correlation with LBP, obesity and these metabolism.Materials and Methods. This prospective study had institutional review board approval, and written informed consent was obtained from all study participants. Forty patients (24 women, 16men; mean age, 64.7 years +/- 12.7; age range, 22-85 years) with LBP duration of >= 3 months, who underwent MRS to quantify IMCL and EMCL of right Mm in a volume interest at the intervertebral level of L4 through L5. We analyzed body mass index (BMI) as an indicator of obesity, and visual analogue score (VAS) as LBP intensity. The associations were analyzed using Spearman's correlation coefficient.Results. The BMI showed correlation with EMCL (r=0.436, p<0.01), but no correlation with IMCL. The VAS showed correlation with IMCL (r=0.657, p<0.01) but no correlation with EMCL.Conclusion. The present study showed a relationship between IMCL in the Mm and chronic LBP. The analysis of Mm with MRS is expected to become an effective objective indicator of chronic LBP., JAPANESE ASSOC STUDY PAIN, Japanese

腰椎椎間板におけるTSL(time of spin lock)の設定とT1 rho値の関係　　　　　　　　　　　　　　　
今村 塁, 高島 弘幸, 中西 光広, 長濱 宏史, 宍戸 博紀, 赤塚 吉紘, 奥秋 知幸, 北海道放射線技術雑誌, 79, 85, 85, Oct. 2015
(公社)日本放射線技術学会-北海道支部, Japanese

中耳および内耳道奇形を伴う顔面神経走行異常 Case report and review of radiological literatures　　　　　　　　　　　　　　　
坂田 元道, 長濱 宏史, 櫻井 佑樹, 須藤 洋平, 赤塚 吉紘, 沼澤 香夏子, 高島 弘幸, 北海道放射線技術雑誌, 79, 101, 101, Oct. 2015
(公社)日本放射線技術学会-北海道支部, Japanese

three-dimensional kurtosis contrast(3DKC)　　　　　　　　　　　　　　　
長濱 宏史, 片桐 好美, 櫻井 佑樹, 鈴木 淳平, 中西 光広, 高島 弘幸, 北海道放射線技術雑誌, 79, 104, 104, Oct. 2015
(公社)日本放射線技術学会-北海道支部, Japanese

陳旧性足関節外側靭帯損傷における3D MRI所見と治療選択
TERAMOTO ATSUSHI, AKATSUKA YOSHIHIRO, TAKASHIMA HIROYUKI, SAKAKIBARA JO, SUZUKI TOMOYUKI, WATANABE KOTA, YAMASHITA TOSHIHIKO, 日本足の外科学会雑誌, 36, 2, S203, S203, 25 Sep. 2015
(一社)日本足の外科学会, Japanese

MRIによる棘上筋脂肪浸潤評価の検者間信頼性
IMAMURA RUI, HIROSE TOSHIAKI, DOKE TAKAYUKI, SHIBAYAMA YUJI, SUGI AKIRA, MIZUSHIMA EMI, TAKASHIMA HIROYUKI, SHISHIDO HIRONORI, AKATSUKA YOSHIHIRO, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 8, S1655, 10 Sep. 2015
Japanese

矢状面脊柱・骨盤アライメントと慢性腰痛に対する薬物治療効果との関連
OGON IZAYA, TAKEBAYASHI TSUNEO, TAKASHIMA HIROYUKI, TAKASHIMA HIROYUKI, TANIMOTO KATSUMASA, KANO MASAYOSHI, TERASHIMA YOSHINORI, YOSHIMOTO MITSUNORI, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 8, S1636, 10 Sep. 2015
Japanese

磁気共鳴分光法(MR spectroscopy)による傍脊柱筋脂肪量と腰痛の関連
TAKASHIMA HIROYUKI, TAKASHIMA HIROYUKI, TAKEBAYASHI TSUNEO, KOGANE IZAYA, IMAMURA RUI, YOSHIMOTO MITSUNORI, TERASHIMA YOSHINORI, KANO MASAYOSHI, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 8, S1698, 10 Sep. 2015
Japanese

MRI T2mappingによる椎間板変性と黄色靱帯肥厚の解析
TAKASHIMA HIROYUKI, TAKASHIMA HIROYUKI, TAKEBAYASHI TSUNEO, YOSHIMOTO MITSUNORI, TERASHIMA YOSHINORI, KANO MASAYOSHI, OGON IZAYA, IMAMURA RUI, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 8, S1616, 10 Sep. 2015
Japanese

足関節外側靭帯損傷の3D MRI所見―新鮮例と陳旧例の比較―
TERAMOTO ATSUSHI, AKATSUKA YOSHIHIRO, TAKASHIMA HIROYUKI, SAKAKIBARA JO, SUZUKI TOMOYUKI, WATANABE KOTA, YAMASHITA TOSHIHIKO, 日本整形外科スポーツ医学会雑誌, 35, 4, 411, 411, 31 Aug. 2015
(一社)日本整形外科スポーツ医学会, Japanese

寛骨臼回転骨切術における寛骨臼の回転シミュレーション
SUZUKI DAISUKE, NAGOYA SATOSHI, OKAZAKI SHUN'ICHIRO, TAKASHIMA HIROYUKI, SASAKI MIKIHITO, KAYA MITSUNORI, TATEDA KENJI, KOSUKEGAWA YUKIMA, ONISHI HITOSHI, SHIMIZU JUN'YA, YAMASHITA TOSHIHIKO, Hip Jt, 41, 184, 188, 25 Aug. 2015
寛骨臼形成不全の女性23名24関節RAO群(平均41.9歳、21～50歳)、正常股関節の女性35名35関節正常群(平均46.9歳、23～59歳)のCT画像を用い、Nagoyaらの(2005)の術式において、適正な大腿骨頭の被覆が得られる術前シミュレーションを目的とした場合、三次元オイラー角を用いた適切な寛骨臼回転角度の算出方法を考案した。RAO群の寛骨臼のx軸中心(矢状面)の角α、y軸中心(冠状面)の角β、z軸(水平面)の角γはそれぞれ30.5±16.3°、48.4±4.3°、25.4±8.2°、正常群では28.8±8.3°、42.5±4.1°、22.1±5.0°であった。RAO群は正常群に比べ冠状面の角βおよび水平面での角γが有意に大きく、またRAO群では角αおよび角γのばらつきが有意に大きかった。本寛骨臼回転シミュレーションはRAOにおける寛骨臼の三次元的な回転角度を計算できるため、より適正な寛骨臼オリエンテーションを獲得する回転角度の決定に役立つと思われた。, 日本股関節学会, Japanese

正常日本人の寛骨臼オリエンテーション
SUZUKI DAISUKE, NAGOYA SATOSHI, OKAZAKI SHUN'ICHIRO, TAKASHIMA HIROYUKI, SASAKI MIKIHITO, KAYA MITSUNORI, TATEDA KENJI, KOSUKEGAWA YUKIMA, ONISHI HITOSHI, SHIMIZU JUN'YA, YAMASHITA TOSHIHIKO, Hip Jt, 41, 842, 846, 25 Aug. 2015
正常股関節70例(男性35例、平均年齢43.9歳、女性35例、平均年齢46.5歳)を対象に、骨盤CT画像より3DCADにて左右軸(x軸)、前後軸(y軸)、上下軸(z軸)からなる右手系の直交座標系を定義し、右大腿骨頭中心を通る右寛骨臼の角度を測定した。平均値で男性の矢状面の角度が23.2°、冠状面の角度が39.4°、水平面の角度が18.9°であり、女性ではそれぞれ28.7°、42.8°、21.9°と男性で全ての角度が有意に小さかった。男性では年齢と冠状面の角度との間に有意な負の相関(R=-0.51)を認めた。, 日本股関節学会, Japanese

MR spectroscopyによる傍脊柱筋脂肪量と非特異的腰痛の関連
TAKASHIMA HIROYUKI, TAKASHIMA HIROYUKI, TAKEBAYASHI TSUNEO, OGON IZAYA, YOSHIMOTO MITSUNORI, TERASHIMA YOSHINORI, IMAMURA RUI, YAMASHITA TOSHIHIKO, Pain Res, 30, 2, 95, 03 Jul. 2015
Japanese

慢性腰痛の疼痛メカニズムに関与する因子とNSAIDsとプレガバリンによる治療効果の検討
OGON IZAYA, TAKEBAYASHI TSUNEO, TAKASHIMA HIROYUKI, TAKASHIMA HIROYUKI, TANIMOTO KATSUMASA, KANO MASANOBU, TERASHIMA YOSHINORI, YOSHIMOTO MITSUNORI, YAMASHITA TOSHIHIKO, Pain Res, 30, 2, 96, 03 Jul. 2015
Japanese

神経根性疼痛における脊髄膠様質細胞のシナプス伝達の変化
TERASHIMA YOSHINORI, TAKEBAYASHI TSUNEO, MIYAKAWA TSUYOSHI, OGON IZAYA, TAKASHIMA HIROYUKI, TANAKA SATOSHI, KAWAMATA MIKITO, YAMASHITA TOSHIHIKO, Pain Res, 30, 2, 114, 03 Jul. 2015
Japanese

人工膝関節大腿骨コンポーネントの回旋設置評価におけるトモシンセシスの有用性
SHOJI HIROAKI, TERAMOTO ATSUSHI, TAKASHIMA HIROYUKI, WATANABE KOTA, YAMASHITA TOSHIHIKO, 整形・災害外科, 58, 8, 1085, 1088, 01 Jul. 2015
2011年8〜10月の間に整形外科を受診した人工膝関節置換術(TKA)後の患者22例24膝(男性4例、女性18例、平均年齢72.1±18.2歳)に対してTKA大腿骨コンポーネントの回旋設置評価におけるトモシンセシス撮影の有用性について検討した。全例にトモシンセシス撮影と単純X線撮影を行い、上顆軸に対する大腿骨コンポーネント軸の傾き(CTA)について検者内再現性および専門医と後期研修医における検者間の再現性を調べた。その結果、単純X線における評価では内外上顆が不明瞭なため専門医、研修医とも3膝でCTA計測が不可と判断され、トモシンセシス撮影では専門医、研修医とも全例でCTA計測が可能であった。検者内の級内相関係数はX線像で0.746、トモシンセシスで0.849であり、専門医と研修医における検者間の級内相関係数はX線像で0.522、トモシンセシスで0.709であった。以上より、トモシンセシス撮影はTKA大腿骨コンポーネントの回旋設置評価において有用であると考えられた。, 金原出版(株), Japanese

バケツ丙断裂に対する関節鏡下半月縫合術の治療成績
KUBOTA CHIHIRO, SUZUKI TOMOYUKI, OKADA YOHEI, KII YUICHIRO, TERAMOTO ATSUSHI, WATANABE KOTA, MATSUMURA TAKASHI, TAKASHIMA HIROYUKI, IMAMURA RUI, OTSUBO HIDENORI, OGASAWARA KAZUHIRO, JOSKAS, 40, 4, 213, 213, 01 Jun. 2015
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

MR spectroscopyを用いた傍脊柱筋脂肪量とJOABPEQの関連
TAKASHIMA HIROYUKI, TAKEBAYASHI TSUNEO, KOGANE IZAYA, YOSHIMOTO MITSUNORI, TERASHIMA YOSHINORI, KANO MASAYOSHI, YAMASHITA TOSHIHIKO, J Spine Res, 6, 3, 553, 25 Mar. 2015
Japanese

慢性腰痛と傍脊柱筋脂肪変性の関連
TAKASHIMA HIROYUKI, TAKEBAYASHI TSUNEO, KOGANE IZAYA, YOSHIMOTO MITSUNORI, TERASHIMA YOSHINORI, KANO MASAYOSHI, YAMASHITA TOSHIHIKO, J Spine Res, 6, 3, 622, 25 Mar. 2015
Japanese

頚部angio CTによるC7横突孔内の血管の特徴
OSHIGIRI TSUTOMU, TAKEBAYASHI TSUNEO, TAKASHIMA HIROYUKI, YOSHIMOTO MITSUNORI, TERASHIMA YOSHINORI, KANO MASAMITSU, YAMASHITA TOSHIHIKO, J Spine Res, 6, 3, 573, 25 Mar. 2015
Japanese

頚部CTによるC7横突孔と椎骨動脈の解析
OSHIGIRI TSUTOMU, TAKEBAYASHI TSUNEO, TAKASHIMA HIROYUKI, YOSHIMOTO MITSUNORI, TERASHIMA YOSHINORI, KANO MASAMITSU, YAMASHITA TOSHIHIKO, J Spine Res, 6, 3, 573, 25 Mar. 2015
Japanese

MRI3Dシーケンスを用いた足関節外側靱帯損傷の経時的評価
TERAMOTO ATSUSHI, AKATSUKA YOSHIHIRO, TAKASHIMA HIROYUKI, WATANABE KOTA, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 3, S698, S698, 12 Mar. 2015
(公社)日本整形外科学会, Japanese

腸腰筋脂肪変性と脊柱アライメントの関連
TAKASHIMA HIROYUKI, TAKEBAYASHI TSUNEO, OGON IZAYA, YOSHIMOTO MITSUNORI, TERASHIMA YOSHINORI, KANO MASAYOSHI, IMAMURA RUI, AKATSUKA YOSHIHIRO, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 3, S636, 12 Mar. 2015
Japanese

慢性腰痛におけるMRI T2mappingによる椎間板変性と神経障害性疼痛の関連について
OGON IZAYA, TAKEBAYASHI TSUNEO, TAKASHIMA HIROYUKI, TANIMOTO KATSUMASA, KANO MASAYOSHI, TERASHIMA YOSHINORI, YOSHIMOTO MITSUNORI, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 3, S637, 12 Mar. 2015
Japanese

頚部CTによるC7横突孔と椎骨動脈の解析
OSHIGIRI TSUTOMU, TAKEBAYASHI TSUNEO, TAKASHIMA HIROYUKI, YOSHIMOTO MITSUNORI, TERASHIMA YOSHINORI, KANO MASAYOSHI, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 3, S547, 12 Mar. 2015
Japanese

半月板縫合術後の画像評価―最新の仮想荷重3D‐MRI―
SUZUKI TOMOYUKI, TAKASHIMA HIROYUKI, OGASAWARA KAZUHIRO, OTSUBO HIDENORI, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 3, S1048, 12 Mar. 2015
Japanese

MRIを用いた内側膝蓋大腿靱帯の三次元的描出
IMAMURA RUI, SUZUKI TOMOYUKI, TAKASHIMA HIROYUKI, AKATSUKA YOSHIHIRO, OKIMURA SHIN'ICHIRO, TERAMOTO ATSUSHI, OTSUBO HIDENORI, WATANABE KOTA, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 3, S751, S751, 12 Mar. 2015
(公社)日本整形外科学会, Japanese

慢性腰痛患者におけるMRI T2mappingによる腰椎椎間板変性と矢状面脊柱・骨盤アライメントの関連について
OGON IZAYA, TAKEBAYASHI TSUNEO, TAKASHIMA HIROYUKI, TANIMOTO KATSUMASA, KANO MASAYOSHI, TERASHIMA YOSHINORI, YOSHIMOTO MITSUNORI, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 3, S547, 12 Mar. 2015
Japanese

MRI3Dシーケンスを用いた足関節肢位による踵腓靱帯の評価
AKATSUKA YOSHIHIRO, TERAMOTO ATSUSHI, TAKASHIMA HIROYUKI, SHISHIDO HIRONORI, IMAMURA RUI, SUZUKI TOMOYUKI, WATANABE KOTA, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 3, S697, S697, 12 Mar. 2015
(公社)日本整形外科学会, Japanese

1H MR spectroscopyによる多裂筋の脂肪変性と腰痛および肥満の関連
TAKASHIMA HIROYUKI, TAKEBAYASHI TSUNEO, OGON IZAYA, YOSHIMOTO MITSUNORI, TERASHIMA YOSHINORI, KANO MASAYOSHI, IMAMURA RUI, AKATSUKA YOSHIHIRO, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 3, S866, 12 Mar. 2015
Japanese

慢性腰痛患者におけるMR spectroscopyによる多裂筋脂肪変性と矢状面脊柱・骨盤アライメントの関連について
OGON IZAYA, TAKEBAYASHI TSUNEO, TAKASHIMA HIROYUKI, TANIMOTO KATSUMASA, KANO MASAYOSHI, TERASHIMA YOSHINORI, YOSHIMOTO MITSUNORI, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 3, S866, 12 Mar. 2015
Japanese

慢性腰痛の疼痛メカニズムに関与する因子とNSAIDsとプレガバリンによる治療効果の検討
OGON IZAYA, TAKEBAYASHI TSUNEO, TAKASHIMA HIROYUKI, TANIMOTO KATSUMASA, KANO MASAYOSHI, TERASHIMA YOSHINORI, YOSHIMOTO MITSUNORI, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 2, S121, 05 Mar. 2015
Japanese

腰椎椎間板変性度および黄色靱帯厚と肥満および年齢との関連について
TAKASHIMA HIROYUKI, TAKEBAYASHI TSUNEO, ONODERA MAKI, KOGANE IZAYA, YOSHIMOTO MITSUNORI, IDA KAZUNORI, TERASHIMA YOSHINORI, TANIMOTO KATSUMASA, KANO MASAYOSHI, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 2, S125, 05 Mar. 2015
Japanese

慢性腰痛患者における傍脊柱筋脂肪変性が薬剤治療効果へ与える影響
TAKASHIMA HIROYUKI, TAKEBAYASHI TSUNEO, KOGANE IZAYA, IMAMURA RUI, YOSHIMOTO MITSUNORI, TERASHIMA YOSHINORI, KANO MASAYOSHI, AKATSUKA YOSHIHIRO, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 2, S121, 05 Mar. 2015
Japanese

腱板断裂患者における腱板筋内腱のMRI評価
MIZUSHIMA EMI, HIROSE TOSHIAKI, YOSHIMOTO SHOTA, DOKE TAKAYUKI, SHIBAYAMA YUJI, SUGI AKIRA, IMAMURA RUI, TAKASHIMA HIROYUKI, OKAMURA KENJI, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 2, S237, 05 Mar. 2015
Japanese

頚部angio CTによるC7横突孔内の血管の特徴
OSHIGIRI TSUTOMU, TAKEBAYASHI TSUNEO, TAKASHIMA HIROYUKI, YOSHIMOTO MITSUNORI, TERASHIMA YOSHINORI, KANO MASAYOSHI, YAMASHITA TOSHIHIKO, 日本整形外科学会雑誌, 89, 2, S115, 05 Mar. 2015
Japanese

難治性上腕骨外上顆炎の症例における上腕骨小頭嚢胞性病変
JIMBO SHUNSUKE, SASAKI KOICHI, TAKASHIMA HIROYUKI, ODA TAKASHI, KANAYA KOHEI, IBA KOSUKE, WADA TAKURO, 日本肘関節学会雑誌, 22, 1, S50, 05 Jan. 2015
Japanese

MRI3Dシーケンスを用いた足関節外側靭帯損傷の経時的評価
TERAMOTO ATSUSHI, AKATSUKA YOSHIHIRO, TAKASHIMA HIROYUKI, WATANABE KOTA, YAMASHITA TOSHIHIKO, 日本足の外科学会雑誌, 35, 2, S198, S198, 14 Oct. 2014
(一社)日本足の外科学会, Japanese

多裂筋における脂肪変性と年齢および腰痛の関連について
TAKASHIMA HIROYUKI, TAKEBAYASHI TSUNEO, KOGANE IZAYA, YOSHIMOTO MITSUNORI, TERASHIMA YOSHINORI, KANO MASAYOSHI, IDA KAZUNORI, TANIMOTO KATSUMASA, YAMASHITA TOSHIHIKO, 日本運動器疼痛学会誌, 6, 3, S42, 30 Sep. 2014
Japanese

可変再収束フリップ角法3D‐T2強調像における入力T2値およびequivalent TEが四肢関節画像に与える影響
IMAMURA RUI, NAGAHAMA HIROSHI, NAKANISHI MITSUHIRO, TAKASHIMA HIROYUKI, SUZUKI JUMPEI, SHISHIDO HIRONORI, AKATSUKA YOSHIHIRO, 日本放射線技術学会雑誌, 70, 9, 1073, 1073, Sep. 2014
(公社)日本放射線技術学会, Japanese

MRI3Dシーケンスによる足関節外側靭帯の評価
赤塚吉紘, 寺本篤史, 高島弘幸, 宍戸博紀, 今村塁, 渡邉耕太, 山下敏彦, 日本整形外科スポーツ医学会雑誌, 34, 4, 495, 495, 31 Aug. 2014
(一社)日本整形外科スポーツ医学会, Japanese

脊柱・骨盤アライメントの慢性腰痛に対する危険因子の検討
黄金勲矢, 竹林庸雄, 高島弘幸, 谷本勝正, 井田和功, 吉本三徳, 山下敏彦, 日本整形外科学会雑誌, 88, 8, S1745, 29 Aug. 2014
Japanese

3D MRIによる腰椎椎間孔部神経根障害の画像解析
高島弘幸, 高島弘幸, 竹林庸雄, 吉本三徳, 井田和功, 宍戸博紀, 今村塁, 赤塚吉紘, 谷本勝正, 寺島嘉紀, 山下敏彦, 日本整形外科学会雑誌, 88, 8, S1505, 29 Aug. 2014
Japanese

半月縫合術後の仮想荷重3D‐MRI解析
鈴木智之, 岡田葉平, 杉憲, 高島弘幸, 菅野洋平, 高橋宗正, 永井克昭, 木井雄一郎, 大坪英則, 寺本篤史, 山下敏彦, 日本整形外科学会雑誌, 88, 8, S1383, S1383, 29 Aug. 2014
(公社)日本整形外科学会, Japanese

Proton MR spectroscopyによる傍脊柱筋脂肪量と腰痛の関連について
高島弘幸, 高島弘幸, 竹林庸雄, 黄金勲矢, 吉本三徳, 井田和功, 谷本勝正, 今村塁, 赤塚吉紘, 山下敏彦, 日本整形外科学会雑誌, 88, 8, S1405, 29 Aug. 2014
Japanese

3D MRIによる腰椎椎間孔部神経根障害の評価
高島弘幸, 竹林庸雄, 吉本三徳, 宍戸博紀, 今村塁, 山下敏彦, 東日本整形災害外科学会雑誌, 26, 3, 238, 19 Aug. 2014
Japanese

今,3Tと1.5Tを使い分ける―それぞれのメリットと特長―Ingenia3.0T/1.5Tの使用経験
中西光広, 高島弘幸, 鈴木淳平, 柳田美香, 長濱宏史, 櫻井佑樹, 今村塁, 白勢竜二, 笹川純市, Rad Fan, 12, 10, 32, 34, Aug. 2014
Philips社製Ingenia3.0T/1.5Tは開口70cmのオープンボアでありながら、優れた静磁場均一性と傾斜磁場直線性を持ち、受信コイルシステムをフルデジタル化し先進アプリケーションを搭載した装置である。当院におけるIngenia3.0T/1.5Tの使用経験と有用性と特徴について紹介する。(著者抄録), (株)メディカルアイ, Japanese

Visualization of the Foramen Intervertebral Nerve Root of Cervical Spine with 3.0 Tesla Magnetic Resonance Imaging : A Comparison of Three-dimensional Acquisition Techniques
宍戸 博紀, 高島 弘幸, 竹林 庸雄, 赤塚 吉紘, 今村 塁, 長濱 宏史, 白勢 竜二, 日本放射線技術学会雑誌, 70, 7, 670, 675, Jul. 2014
3.0T MRIを用いた頸椎椎間孔部神経根描出における三次元収集撮像シーケンスについて検討した。脳脊髄液と脊髄において、CNRはFIESTA、COSMIC、FS-COSMIC、SWANの順に高く、SWANを除いたFIESTA、COSMIC、FS-COSMICでは有意差を認めなかった。椎間孔部における神経根と椎弓の信号強度比では、すべてのシーケンス間で有意差を認め、信号強度比はFS-COSMIC、COSMIC、FIESTA、SWANの順に高かった。脳脊髄液と脊髄の視覚的評価では、FIESTAシーケンスと比較し、FIESTAシーケンスがよく描出した。また、脂肪抑制の有無による結果にも変化は認めなかった。椎間孔部における神経根と椎弓の視覚的評価では、脂肪抑制を追加したFS-COSMICシーケンスが最もよく描出した。SWANで得られた視覚評価の結果がすべての撮像シーケンスと有意差を認めた。, (公社)日本放射線技術学会, Japanese

Visualization of the Foramen Intervertebral Nerve Root of Cervical Spine with 3.0 Tesla Magnetic Resonance Imaging: A Comparison of Three-dimensional Acquisition Techniques
SHISHIDO HIROKI, TAKASHIMA HIROYUKI, TAKEBAYASHI TSUNEO, AKATSUKA YOSHIHIRO, IMAMURA RUI, NAGAHAMA HIROSHI, SHIRASE RYUJI, 日本放射線技術学会雑誌, 70, 7, 670, 675, Jul. 2014
3.0T MRIを用いた頸椎椎間孔部神経根描出における三次元収集撮像シーケンスについて検討した。脳脊髄液と脊髄において、CNRはFIESTA、COSMIC、FS-COSMIC、SWANの順に高く、SWANを除いたFIESTA、COSMIC、FS-COSMICでは有意差を認めなかった。椎間孔部における神経根と椎弓の信号強度比では、すべてのシーケンス間で有意差を認め、信号強度比はFS-COSMIC、COSMIC、FIESTA、SWANの順に高かった。脳脊髄液と脊髄の視覚的評価では、FIESTAシーケンスと比較し、FIESTAシーケンスがよく描出した。また、脂肪抑制の有無による結果にも変化は認めなかった。椎間孔部における神経根と椎弓の視覚的評価では、脂肪抑制を追加したFS-COSMICシーケンスが最もよく描出した。SWANで得られた視覚評価の結果がすべての撮像シーケンスと有意差を認めた。, (公社)日本放射線技術学会, Japanese

内側膝蓋大腿靭帯の三次元的描出
興村慎一郎, 鈴木智之, 今村塁, 赤塚吉紘, 高島弘幸, 山下敏彦, JOSKAS, 39, 4, 258, 01 Jul. 2014
Japanese

Radiologic analysis with computed tomography of the occipital bone
森田 智慶, 竹林 庸雄, 高島 弘幸, 整形外科 = Orthopedic surgery, 65, 5, 401, 405, May 2014
南江堂, Japanese

CTを用いた後頭骨の形態学的研究
森田智慶, 竹林庸雄, 高島弘幸, 吉本三徳, 井田和功, 谷本勝正, 山下敏彦, 整形外科, 65, 5, 401, 405, 01 May 2014
健常成人80例を対象に、CTを用い後頭骨の厚さを計測した。測定部位は外後頭隆起(EOP)を基準として両側方に5cm、下方に4cmの1cm間隔の部位で、計11×5ヶ所とした。その結果、8mm以上の厚さがある範囲はEOPの高さでは両側方2cmまで、1cm下方の高さでは両側方1cmまで、下方はEOPより3cmまでであった。性別で比較したところ、男女とも8mm以上の厚さがある範囲は同じであったが、男性は女性より厚い傾向があり、EOP周囲に有意差がみられた。また、後頭骨の厚さに対する海綿骨の割合を算出したところ、外側へ向けて徐々に割合が小さくなる傾向があった。以上より、従来参考にしている範囲よりも広範囲にスクリューを刺入できる可能性が示唆された。, 南江堂, Japanese

Intravoxel incoherent motion(IVIM)におけるb値の選択が計測精度に与える影響
今村塁, 高島弘幸, 宍戸博紀, 赤塚吉紘, 柳田美香, 北海道放射線技術雑誌, 76, 38, 39, 31 Mar. 2014
Japanese

320列CTにおける心電図同期撮影法の違いによる撮影時間の比較
小倉圭史, 吉川健太, 蝶野大樹, 三角昌吾, 中西光広, 今井達也, 櫻井佑樹, 沼澤香夏子, 高島弘幸, 北海道放射線技術雑誌, 76, 22, 23, 31 Mar. 2014
Japanese

腰椎椎間板変性度と黄色靭帯厚の関連―MRI T2値による解析―
高島弘幸, 竹林庸雄, 吉本三徳, 井田和功, 谷本勝正, 山下敏彦, J Spine Res, 5, 3, 571, 25 Mar. 2014
Japanese

脊柱・骨盤アライメントと慢性腰痛の関連性についての検討
黄金勲矢, 竹林庸雄, 高島弘幸, 谷本勝正, 井田和功, 吉本三徳, 山下敏彦, J Spine Res, 5, 3, 618, 25 Mar. 2014
Japanese

MRI T2強調画像の信号強度比による神経鞘腫と髄膜腫の鑑別
竹林庸雄, 高島弘幸, 吉本三徳, 井田和功, 谷本勝正, 山下敏彦, J Spine Res, 5, 3, 212, 25 Mar. 2014
Japanese

3D‐CTを用いた変形性肘関節症の肘頭骨棘形態分類の試み
佐々木浩一, 恩田和範, 大木豪介, 金谷耕平, 射場浩介, 青木光広, 高島弘幸, 和田卓郎, 山下敏彦, 日本整形外科学会雑誌, 88, 3, S780, 12 Mar. 2014
Japanese

慢性腰痛に対するロルノキシカムおよびプレガバリン併用効果の検討
黄金勲矢, 竹林庸雄, 高島弘幸, 谷本勝正, 井田和功, 吉本三徳, 山下敏彦, 日本整形外科学会雑誌, 88, 2, S177, 05 Mar. 2014
Japanese

MRI T2強調画像の信号強度による神経鞘腫と髄膜腫の鑑別
高島弘幸, 竹林庸雄, 吉本三徳, 小野寺麻希, 井田和功, 谷本勝正, 山下敏彦, 日本整形外科学会雑誌, 88, 2, S192, 05 Mar. 2014
Japanese

MRI T2mappingを用いた腰椎椎間板変性度と黄色靱帯厚の関連について
高島弘幸, 竹林庸雄, 吉本三徳, 井田和功, 谷本勝正, 山下敏彦, 日本整形外科学会雑誌, 88, 2, S189, 05 Mar. 2014
Japanese

Proton MR spectroscopyを用いた慢性腰痛患者の傍脊柱筋の脂肪量の解析
高島弘幸, 竹林庸雄, 黄金勲矢, 吉本三徳, 井田和功, 谷本勝正, 山下敏彦, 日本整形外科学会雑誌, 88, 2, S193, 05 Mar. 2014
Japanese

骨粗鬆症性椎体骨折の予後予測におけるダイナミック造影MRIの有効性
嘉野真允, 高島弘幸, 井田和功, 吉本三徳, 竹林庸雄, 山下敏彦, 日本整形外科学会雑誌, 88, 2, S194, 05 Mar. 2014
Japanese

体位による肩峰上腕骨頭間距離の変化―トモシンセシスを用いた検討―
道家孝幸, 廣瀬聰明, 今村塁, 高島弘幸, 芝山雄二, 杉憲, 岡村健司, 山下敏彦, 日本整形外科学会雑誌, 88, 2, S216, 05 Mar. 2014
Japanese

CTを用いた大腿骨骨性隆起の検討―femoroacetabular impingement(FAI)症例と正常股関節例の比較―
小助川維摩, 大坪英則, 廣田亮介, 赤塚吉紘, 高島弘幸, 加谷光規, 佐々木幹人, 山下敏彦, 名越智, 日本整形外科学会雑誌, 88, 2, S241, 05 Mar. 2014
Japanese

b値がテンソル解析に与える影響
高島弘幸, 宍戸博紀, 今村塁, 赤塚吉紘, 柳田美香, 中西光広, 長濱宏史, 白勢竜二, 鈴木淳平, 北海道放射線技術雑誌, 76, 76, 50, 51, Mar. 2014
(公社)日本放射線技術学会-北海道支部, Japanese

拡散強調像を用いた粘度測定の試み
中西光広, 三角昌吾, 蝶野大樹, 吉川健太, 今井達也, 高島弘幸, 櫻井佑樹, 沼澤香夏子, 長濱宏史, 小倉圭史, 北海道放射線技術雑誌, 76, 76, 60, 61, Mar. 2014
(公社)日本放射線技術学会-北海道支部, Japanese

脊柱・骨盤アライメントと慢性腰痛の関連性についての検討
黄金勲矢, 竹林庸雄, 高島弘幸, 谷本勝正, 井田和功, 吉本三徳, 山下敏彦, 北海道整形災害外科学会, 126th, 46, 2014
Japanese

MRIによる棘上筋脂肪変性評価における検者間信頼性―Dixon法を用いたfat‐fractionの評価―
今村塁, 廣瀬聰明, 杉憲, 芝山雄二, 道家孝幸, 高島弘幸, 宍戸博紀, 赤塚吉紘, 山下敏彦, 北海道整形災害外科学会, 127th, 80, 2014
Japanese

慢性腰痛に対するロルノキシカムおよびプレガバリン併用効果の検討
黄金勲矢, 竹林庸雄, 高島弘幸, 谷本勝正, 井田和功, 吉本三徳, 山下敏彦, 北海道整形災害外科学会, 126th, 44, 2014
Japanese

MRI T2強調像による神経鞘腫と髄膜腫の鑑別
高島弘幸, 竹林庸雄, 吉本三徳, 小野寺麻希, 井田和功, 谷本勝正, 山下敏彦, 北海道整形災害外科学会, 126th, 53, 2014
Japanese

MRI3Dシーケンスを用いた足関節肢位による踵腓靭帯の評価
赤塚吉紘, 寺本篤史, 高島弘幸, 宍戸博紀, 今村塁, 鈴木智之, 渡邉耕太, 山下敏彦, 北海道整形災害外科学会, 127th, 114, 2014
Japanese

Proton MR spectroscopyによる傍脊柱筋筋細胞内脂肪と腰痛の関連について
高島弘幸, 竹林庸雄, 黄金勲矢, 吉本三徳, 今村塁, 赤塚吉紘, 寺島嘉紀, 山下敏彦, 北海道整形災害外科学会, 127th, 42, 2014
Japanese

MRI3Dシーケンスによる足関節外側靭帯の評価
赤塚吉紘, 寺本篤史, 高島弘幸, 宍戸博紀, 今村塁, 渡邉耕太, 山下敏彦, 北海道整形災害外科学会, 126th, 4, 118, 495, 2014
(一社)日本整形外科スポーツ医学会, Japanese

小児環椎外側塊発生の好酸球肉芽腫の一例
竹林庸雄, 吉本三徳, 寺島嘉紀, 嘉野真允, 押切勉, 高島弘幸, 山下敏彦, 北海道整形災害外科学会, 127th, 35, 2014
Japanese

腱板断裂患者における肩峰上腕骨頭間距離~トモシンセシスを用いた検討~
道家孝幸, 廣瀬聰明, 今村塁, 芝山雄二, 杉憲, 高島弘幸, 岡村健司, 山下敏彦, 北海道整形災害外科学会, 126th, 81, 2014
Japanese

Proton MR spectroscopyを用いた慢性腰痛患者の傍脊柱筋の脂肪量の解析
高島弘幸, 竹林庸雄, 黄金勲矢, 吉本三徳, 今村塁, 赤塚吉紘, 井田和功, 谷本勝正, 山下敏彦, 北海道整形災害外科学会, 126th, 58, 2014
Japanese

変形性肘関節症に対する骨棘形態の解析
佐々木浩一, 恩田和範, 大木豪介, 金谷耕平, 射場浩介, 和田卓郎, 高島弘幸, 山下敏彦, 北海道整形災害外科学会, 126th, 90, 2014
Japanese

トモシンセシスを用いた遠位脛腓靱帯結合荷重撮影
TERAMOTO ATSUSHI, WATANABE KOTA, YAMASHITA TOSHIHIKO, TAKASHIMA HIROYUKI, 整形・災害外科, 56, 12, 1509, 1512, 01 Nov. 2013
健常者15名(男12名、女3名、平均年齢33.5±7.5歳)を対象に荷重条件での足関節冠状断トモシンセシス撮影を行い、遠位脛腓靱帯結合の生理的開大を評価し、有用性について検討した。撮影肢位は臥位ではFPDに足部を載せ、荷重位では20°の楔状台で片脚立位をとって足関節背屈20°として脛骨天蓋レベルでの遠位脛腓間距離を計測した。その結果、全症例において臥位、荷重背屈位ともトモシンセシスにより遠位脛腓関節は明瞭に描出され、遠位脛腓関節の評価は可能であった。また、遠位脛腓間距離は臥位で平均3.1±0.9mm、立位で平均3.8±0.9mmと増加し、両群間には有意差が認められたほか、背屈荷重時には遠位脛腓靱帯結合の生理的開大が生じることが判明した。, 金原出版(株), Japanese

MR Spectroscopyを用いた慢性腰痛患者の傍脊柱筋の脂肪変性
TAKASHIMA HIROYUKI, TAKEBAYASHI TSUNEO, OGON IZAYA, SHIRASE RYUJI, YOSHIMOTO MITSUNORI, IDA KAZUNORI, TANIMOTO KATSUMASA, YAMASHITA TOSHIHIKO, 日本運動器疼痛学会誌, 5, 3, S66, 01 Nov. 2013
Japanese

腰椎椎間板のMRI T2値と腰痛の相関に関する検討
黄金勲矢, 竹林庸雄, 高島弘幸, 谷本勝正, 井田和功, 吉本三徳, 山下敏彦, 日本運動器疼痛学会誌, 5, 3, S54, 01 Nov. 2013
Japanese

慢性腰痛に対するプレガバリンおよびロルノキシカム併用効果の検討
黄金勲矢, 竹林庸雄, 高島弘幸, 谷本勝正, 井田和功, 吉本三徳, 山下敏彦, 日本運動器疼痛学会誌, 5, 3, S80, 01 Nov. 2013
Japanese

拡散強調像におけるb値がテンソル解析に与える影響
高島弘幸, 宍戸博紀, 今村塁, 赤塚吉紘, 柳田美香, 中西光広, 白勢竜二, 北海道放射線技術雑誌, 75, 104, 25 Oct. 2013
Japanese

拡散強調像を用いた粘度測定の試み
中西光広, 小倉圭史, 高島弘幸, 長濱宏史, 櫻井佑樹, 蝶野大樹, 今井達也, 北海道放射線技術雑誌, 75, 75, 104, 104, Oct. 2013
(公社)日本放射線技術学会-北海道支部, Japanese

トモシンセシス撮影による距骨下関節可動域評価
寺本篤史, 渡邉耕太, 高島弘幸, 赤塚吉紘, 山下敏彦, 日本整形外科スポーツ医学会雑誌, 33, 4, 452, 452, 31 Aug. 2013
(一社)日本整形外科スポーツ医学会, Japanese

脊髄腫瘍に対するMRI T2値による解析
竹林庸雄, 高島弘幸, 吉本三徳, 井田和功, 谷本勝正, 寺島嘉紀, 山下敏彦, 日本整形外科学会雑誌, 87, 8, S1441, 30 Aug. 2013
Japanese

腰椎椎間板のMRIT2値と腰痛の相関に関する検討
黄金勲矢, 竹林庸雄, 高島弘幸, 森田智慶, 村田憲治, 谷本勝正, 井田和功, 吉本三徳, 山下敏彦, 日本整形外科学会雑誌, 87, 8, S1621, 30 Aug. 2013
Japanese

ダイナミック造影MRI(DCE‐MRI)を用いた椎体血流動態の解析
嘉野真允, 高島弘幸, 竹林庸雄, 井田和功, 吉本三徳, 山下敏彦, 日本整形外科学会雑誌, 87, 8, S1446, 30 Aug. 2013
Japanese

人体ファントムを用いた全脊椎CTの被曝線量の検討
高島弘幸, 竹林庸雄, 吉本三徳, 井田和功, 宍戸博紀, 赤塚吉紘, 今村塁, 山下敏彦, 日本整形外科学会雑誌, 87, 8, S1439, 30 Aug. 2013
Japanese

MRIによるACL線維束構造描出における最適断面の検討
赤塚吉紘, 大坪英則, 高島弘幸, 渡邉耕太, 宍戸博紀, 今村塁, 工藤未来, 鈴木智之, 山下敏彦, 史野根性, 日本整形外科学会雑誌, 87, 8, S1642, 30 Aug. 2013
Japanese

CT画像によるα角計測の信頼性
廣田亮介, 大坪英則, 小助川維摩, 大西浩文, 赤塚吉紘, 高島弘幸, 加谷光規, 佐々木幹人, 名越智, 山下敏彦, JOSKAS, 38, 4, 421, 01 Jun. 2013
Japanese

Cam type FAIにおける大腿骨頸部骨性隆起―CT画像を用いた健常日本人での検討
小助川維摩, 大坪英則, 廣田亮介, 赤塚吉紘, 高島弘幸, 加谷光規, 佐々木幹人, 山下敏彦, 名越智, JOSKAS, 38, 4, 421, 01 Jun. 2013
Japanese

Optimized Magnetic Resonance Sequences and Parameters with Operative Assisted Images for Radical Prostatectomy at 3 Tesla-Magnetic Resonance Image
Shirase Ryuji, Sakurai Yuuki, Nagahama Hiroshi, Harada Kuniaki, Takashima Hiroyuki, Nakanishi Mitsuhiro, Harada Kohei, Shishido Hiroki, Imamura Rui, Sakata Motomichi, Hatakenaka Masamitsu, Japanese Journal of Radiological Technology, 69, 5, 529, 534, May 2013
The objective of our study was to optimize magnetic resonance image (MRI) sequences and parameters using operative assisted images (three-dimensional images) for radical prostatectomy at 3 tesla (T) MRI. Five healthy volunteers underwent MRI on the 3.0 T scanner. Various sequences and parameters [Cube (TE/TR=18, 50, 90 ms/2000 ms), FIESTA (TE/TR/FA=2.4 ms/5 ms/40°, 90°), fSPGR (TE/TR/FA=2.3 ms/11.2 ms/20°), slice thickness=1.2 mm, matrix=192×160] were respectively compared. Several structures of the pelvis (the central zones and transition zones of the prostate, the peripheral zones of the prostate, seminal vesicles, rectum wall, bladder, muscle and fat) were determined. The signal intensities of these structures were measured on reformatted axial images and compared against several structures of the pelvis. Correlation with various sequences and parameters was based on the signal-to-noise ratio (SNR), the contrast ratio (CR) and the presence of artifacts. Student's t-test was used for statistical analysis. With Cube (TE/TR=50 ms/2000 ms), the average value of visual evaluation with artifacts was high, and SNR and CR were higher than for other sequence and parameters. Optimized MRI sequences and parameters were Cube (TE/TR=50 ms/2000 ms) which provides improved SNR and CR and the presence of artifacts with operative assisted images for radical prostatectomy. These operative assisted images obtained from Cube (TE/TR=50 ms/2000 ms) are likely to be useful for surgery., 公益社団法人 日本放射線技術学会, Japanese

Optimized Magnetic Resonance Sequences and Parameters with Operative Assisted Images for Radical Prostatectomy at 3 Tesla-Magnetic Resonance Image
SHIRASE Ryuji, SAKURAI Yuuki, NAGAHAMA Hiroshi, HARADA Kuniaki, TAKASHIMA Hiroyuki, NAKANISHI Mitsuhiro, HARADA Kohei, SHISHIDO Hiroki, IMAMURA Rui, SAKATA Motomichi, HATAKENAKA Masamitsu, 日本放射線技術学会雑誌, 69, 5, 529, 534, May 2013
3T-MR装置を用い、根治的前立腺全摘除術に対する支援画像(3D画像)に適した撮像方法について検討した。シーケンスはfast spin-echo sequence-Cube、three-dimensional fast imaging employing steady state acquisition(FIESTA)、three-dimensional fast spoiled gradient recalled acquisition in the steady state(fSPGR)を用い、Cubeではeco time(TE)を変化させて3通り、FIESTAではflip angle(FA)を変えて2通りの計6通りの撮像条件とし、健常者5名(平均48.4歳)を対象に10ヶ所の領域でアーチファクト、signal-to-noise ratio(SNR)、コントラスト比を評価した。その結果、アーチファクトのスコアはFIESTA群が1.8以上、CubeおよびfSPGRは0〜0.8であった。SNRが最も高値を示したのはFIEST(FA 40°)であったが、アーチファクトのスコアは2.0であった。最終結果として、最も適切な撮像方法はCube(TE 50ms/TR 2000ms)であった。, (公社)日本放射線技術学会, Japanese

腰椎疾患に対する診断・評価の進歩 1.画像および機能診断 腰仙椎移行部の外側病変に対する神経根造影後CTの有用性
阿部恭久, 吉本三徳, 竹林庸雄, 井田和功, 高島弘幸, 山下敏彦, 別冊整形外科, 63, 2, 5, 15 Apr. 2013
腰仙椎移行部の外側病変に対する神経根造影後CT(CTR)の有用性について検討した。片側のL5神経根症状を呈しCTRを施行した症例で、狭窄部位に対する内視鏡下除圧術を施行後に症状が改善した115例を対象とした。通常の脊柱管内狭窄(脊柱管群)95例、椎間孔内および椎間孔外狭窄(外側群)20例であった。全例において造影剤による神経根の描出を確認できた。CTRでは外側群の全例において、L5神経の造影剤陰影は著明に狭窄もしくは消失した(狭窄あり)。脊柱管群も、19例に造影剤陰影の狭窄および消失を認めた。椎間孔内・外狭窄に対する、CTRの絞扼所見による診断の感度は100%、特異度は80%であった。L5神経を挟む骨性要素間の最小距離であるRの平均値は、脊柱管群と比較して外側群で有意に小さかった。椎間孔内・外狭窄の診断におけるRのカットオフ値を4.6mmとすると、感度は95%、特異度は89.3%であった。, (株)南江堂, Japanese

トモシンセシスにおける被ばく線量低減の試み
赤塚吉紘, 高島弘幸, 宍戸博紀, 今村塁, 浅沼治, 小笠原将士, 吉井勇治, 赤石泰一, 瀧川明宏, 佐藤順一, 武田浩光, 北海道放射線技術雑誌, 74, 74, 52, 53, 29 Mar. 2013
(公社)日本放射線技術学会-北海道支部, Japanese

全脊椎CTにおける乳腺被ばく線量とリスク
高島弘幸, 竹林庸雄, 武田浩光, 浅沼治, 赤塚吉紘, 宍戸博紀, 今村塁, 吉本三徳, 井田和功, 谷本勝正, 山下敏彦, J Spine Res, 4, 3, 745, 25 Mar. 2013
Japanese

骨粗鬆性椎体骨折の予後予測におけるダイナミック造影MRI(DCE‐MRI)の有効性
嘉野真允, 竹林庸雄, 高島弘幸, 井田和功, 吉本三徳, 山下敏彦, J Spine Res, 4, 3, 803, 25 Mar. 2013
Japanese

神経鞘腫と髄膜腫の画像診断(CT/MRI)による鑑別
竹林庸雄, 大島雄一郎, 高島弘幸, 吉本三徳, 井田和功, 谷本勝正, 寺島嘉紀, 山下敏彦, J Spine Res, 4, 3, 628, 25 Mar. 2013
Japanese

荷重CTを用いた腰椎椎間孔部の検討
村田憲治, 吉本三徳, 竹林庸雄, 井田和功, 谷本勝正, 高島弘幸, 河村秀仁, 山下敏彦, J Spine Res, 4, 3, 211, 25 Mar. 2013
Japanese

MRI T2値による脊髄腫瘍の解析
竹林庸雄, 高島弘幸, 吉本三徳, 井田和功, 谷本勝正, 寺島嘉紀, 山下敏彦, J Spine Res, 4, 3, 629, 25 Mar. 2013
Japanese

慢性腰痛と腰椎椎間板MRI T2値の相関に関する検討
黄金勲矢, 竹林庸雄, 高島弘幸, 吉本三徳, 井田和功, 谷本勝正, 森田智慶, 村田憲治, 山下敏彦, J Spine Res, 4, 3, 802, 25 Mar. 2013
Japanese

腰椎alignmentと椎間板変性の関係―MRI T2 mappingによる解析―
高島弘幸, 竹林庸雄, 吉本三徳, 宍戸博紀, 今村塁, 赤塚吉紘, 井田和功, 谷本勝正, 山下敏彦, J Spine Res, 4, 3, 722, 25 Mar. 2013
Japanese

トモシンセシスを用いた腰椎不安定性の評価
谷本勝正, 竹林庸雄, 吉本三徳, 井田和功, 家里典幸, 山下敏彦, 高島弘幸, J Spine Res, 4, 3, 296, 25 Mar. 2013
Japanese

椎間孔部神経根の描出に関する3D MRI撮像法の比較
高島弘幸, 竹林庸雄, 宍戸博紀, 吉本三徳, 今村塁, 赤塚吉紘, 井田和功, 谷本勝正, 山下敏彦, J Spine Res, 4, 3, 541, 25 Mar. 2013
Japanese

Computed tomographyを用いた後頭骨の形態学的研究
森田智慶, 竹林庸雄, 高島弘幸, 吉本三徳, 井田和功, 谷本勝正, 黄金勲矢, 村田憲治, 山下敏彦, J Spine Res, 4, 3, 296, 25 Mar. 2013
Japanese

腰椎alignmentが椎間板変性に与える影響―MRI T2mappingによる解析―
高島弘幸, 竹林庸雄, 吉本三徳, 井田和功, 谷本勝正, 宍戸博紀, 赤塚吉紘, 今村塁, 山下敏彦, 日本整形外科学会雑誌, 87, 3, S794, 12 Mar. 2013
Japanese

1H(プロトン)MR spectroscopyによる等尺性収縮における筋代謝物変化
高島弘幸, 竹林庸雄, 宍戸博紀, 今村塁, 赤塚吉紘, 山下敏彦, 日本整形外科学会雑誌, 87, 3, S803, 12 Mar. 2013
Japanese

3D MRIによる椎間孔部神経根の描出に関する検討
高島弘幸, 竹林庸雄, 宍戸博紀, 吉本三徳, 今村塁, 井田和功, 谷本勝正, 赤塚吉紘, 山下敏彦, 日本整形外科学会雑誌, 87, 3, S795, 12 Mar. 2013
Japanese

CT画像によるα角計測の再現性と信頼性についての統計学的解析
廣田亮介, 大坪英則, 小助川維摩, 大西浩文, 赤塚吉紘, 高島弘幸, 佐々木幹人, 加谷光規, 山下敏彦, 名越智, 日本整形外科学会雑誌, 87, 2, S14, 05 Mar. 2013
Japanese

CT像を用いた健常大腿骨頚部α角の検討
小助川維摩, 大坪英則, 廣田亮介, 赤塚吉紘, 高島弘幸, 佐々木幹人, 加谷光規, 山下敏彦, 名越智, 日本整形外科学会雑誌, 87, 2, S446, 05 Mar. 2013
Japanese

ヒト正常ACLの3線維束構造―組織学的観察および画像解析による検討―
大坪英則, 史野根生, 赤塚吉紘, 鈴木大輔, 高島弘幸, 鈴木智之, 黒田未来, 渡邉耕太, 藤宮峯子, 山下敏彦, 日本整形外科学会雑誌, 87, 2, S466, 05 Mar. 2013
Japanese

MRIによるACL3線維束構造の描出
赤塚吉紘, 大坪英則, 高島弘幸, 宍戸博紀, 今村塁, 黒田未来, 鈴木智之, 渡邉耕太, 山下敏彦, 史野根生, 日本整形外科学会雑誌, 87, 2, S243, 05 Mar. 2013
Japanese

トモシンセシスによる距骨下関節ストレス撮影
寺本篤史, 渡邉耕太, 高島弘幸, 赤塚吉紘, 小林拓馬, 木井雄一郎, 山下敏彦, 日本整形外科学会雑誌, 87, 2, S475, S475, 05 Mar. 2013
(公社)日本整形外科学会, Japanese

トモシンセシスを用いた腰椎不安定性の評価
谷本勝正, 竹林庸雄, 吉本三徳, 井田和功, 家里典幸, 井畑朝起, 成田有子, 千葉充将, 山下敏彦, 高島弘幸, 赤塚吉紘, 日本整形外科学会雑誌, 87, 2, S357, 05 Mar. 2013
Japanese

Computed tomographyを用いた後頭骨の形態学的研究
森田智慶, 竹林庸雄, 吉本三徳, 井田和功, 谷本勝正, 黄金勲矢, 村田憲治, 高島弘幸, 山下敏彦, 日本整形外科学会雑誌, 87, 2, S399, 05 Mar. 2013
Japanese

MRI T2mappingによる腰椎すべり症の発症メカニズムの解析
竹林庸雄, 高島弘幸, 吉本三徳, 寺島嘉紀, 井田和功, 谷本勝正, 山下敏彦, 日本整形外科学会雑誌, 87, 2, S391, 05 Mar. 2013
Japanese

荷重CTを用いた腰椎椎間孔部の検討
村田憲治, 吉本三徳, 竹林庸雄, 井田和功, 谷本勝正, 河村秀仁, 高島弘幸, 山下敏彦, 日本整形外科学会雑誌, 87, 2, S264, 05 Mar. 2013
Japanese

3point‐Dixon法を用いた脂肪含有率測定における緩和時間の影響
今村塁, 高島弘幸, 宍戸博紀, 赤塚吉紘, 長濱宏史, 櫻井佑樹, 白勢竜二, 北海道放射線技術雑誌, 74, 74, 4, 5, Mar. 2013
(公社)日本放射線技術学会-北海道支部, Japanese

トモシンセシスを用いた体位変換における肩峰‐上腕骨頭距離の変化
道家孝幸, 廣瀬聰明, 今村塁, 高島弘幸, 芝山雄二, 杉憲, 木村重治, 吉本正太, 上野栄和, 堀籠圭子, 岡村健司, 山下敏彦, 北海道整形災害外科学会, 125th, 73, 2013
Japanese

3D‐CTを用いた変形性肘関節症の骨棘部位と可動域の関連
佐々木浩一, 恩田和範, 大木豪介, 金谷耕平, 射場浩介, 和田卓郎, 山下敏彦, 青木光広, 高島弘幸, 北海道整形災害外科学会, 124th, 100, 2013
Japanese

CT像を用いた健常大腿骨頸部α角の検討
小助川維摩, 大坪英則, 廣田亮介, 山下敏彦, 名越智, 赤塚吉紘, 高島弘幸, 佐々木幹人, 加谷光規, 北海道整形災害外科学会, 124th, 90, 2013
Japanese

CTを用いた大腿骨骨性隆起の検討―Femoroacetabular impingement(FAI)症例と正常股関節例の比較
小助川維摩, 大坪英則, 廣田亮介, 赤塚吉紘, 高島弘幸, 加谷光規, 佐々木幹人, 山下敏彦, 名越智, 日本股関節学会学術集会プログラム・抄録集, 40th, 448, 2013
Japanese

全脊椎CTの被ばく線量とリスク
高島弘幸, 竹林庸雄, 赤塚吉紘, 宍戸博紀, 今村塁, 吉本三徳, 山下敏彦, 北海道整形災害外科学会, 125th, 49, 2013
Japanese

3D MRIによる腰椎椎間孔部神経根障害の診断
高島弘幸, 宍戸博紀, 今村塁, 赤塚吉紘, 竹林庸雄, 吉本三徳, 井田和功, 谷本勝正, 山下敏彦, 北海道整形災害外科学会, 124th, 70, 2013
Japanese

3T‐MRIによるACL3線維束構造の描出
赤塚吉紘, 宍戸博紀, 今村塁, 高島弘幸, 大坪英則, 工藤未来, 鈴木智之, 渡邊耕太, 山下敏彦, 史野根生, 北海道整形災害外科学会, 124th, 20, 2013
Japanese

MRI T2値による脊髄腫瘍の解析
竹林庸雄, 吉本三徳, 井田和功, 谷本勝正, 山下敏彦, 高島弘幸, 北海道整形災害外科学会, 124th, 69, 2013
Japanese

慢性腰痛と腰椎椎間板MRI T2値の相関に関する検討
黄金勲矢, 竹林庸雄, 森田智慶, 村田憲治, 谷本勝正, 井田和功, 吉本三徳, 山下敏彦, 高島弘幸, 北海道整形災害外科学会, 124th, 70, 2013
Japanese

MRIによるACL線維束構造描出における最適断面の検討
赤塚吉紘, 大坪英則, 高島弘幸, 渡邉耕太, 宍戸博紀, 今村塁, 工藤未来, 鈴木智之, 山下敏彦, 史野根性, 北海道整形災害外科学会, 125th, 103, 2013
Japanese

トモシンセシスを用いた腰椎不安定性の評価
谷本勝正, 竹林庸雄, 吉本三徳, 井田和功, 家里典幸, 井畑朝起, 成田有子, 千葉充将, 山下敏彦, 高島弘幸, 赤塚吉紘, 北海道整形災害外科学会, 124th, 15, 2013
Japanese

CT画像によるα角計測の信頼性
廣田亮介, 大坪英則, 小助川維摩, 大西浩文, 赤塚吉紘, 高島弘幸, 佐々木幹人, 加谷光規, 山下敏彦, 名越智, 日本股関節学会学術集会プログラム・抄録集, 40th, 447, 2013
Japanese

CT画像によるα角計測の再現性と信頼性についての統計学的解析
廣田亮介, 大坪英則, 小助川維摩, 佐々木幹人, 山下敏彦, 大西浩文, 赤塚吉紘, 高島弘幸, 加谷光規, 名越智, 北海道整形災害外科学会, 124th, 89, 2013
Japanese

腰椎すべり症に対するトモシンセシスを用いた画像評価
谷本勝正, 竹林庸雄, 吉本三徳, 井田和功, 家里典幸, 濱田修人, 山下敏彦, 高島弘幸, 赤塚吉紘, 北海道整形災害外科学会, 125th, 57, 2013
Japanese

CTを用いた大腿骨骨性隆起の検討.femoroacetabular impingement(FAI)症例と正常股関節例の比較
小助川維摩, 大坪英則, 廣田亮介, 赤塚吉紘, 高島弘幸, 加谷光規, 佐々木幹人, 山下敏彦, 名越智, 北海道整形災害外科学会, 125th, 83, 2013
Japanese

骨粗鬆性椎体骨折の予後予測におけるダイナミック造影MRI(DCE‐MRI)の有効性
嘉野真允, 竹林庸雄, 井田和功, 吉本三徳, 山下敏彦, 高島弘幸, 北海道整形災害外科学会, 124th, 63, 2013
Japanese

2012 Report of Training in Stanford University (Abstract)
田中 利恵, 宇野 貴寛, 遠地 志太, 大下 剛史, 黒木 英郁, 小林 正和, 佐藤 英介, 高島 弘幸, 高津 安男, 谷川 琢海, 土屋 裕一郎, 寺内 香澄, 中村 麻名美, 福澤 圭, 丸山 裕稔, 三輪 建太, 室井 健三, 山谷 裕哉, 横岡 由姫, 吉田 耕治, 若林 康治, Japanese Journal of Radiological Technology, 69, 2, 217, 225, 2013
Japanese Society of Radiological Technology, Japanese

安全第一MRI
高島弘幸, 北海道放射線技術雑誌, 73, 73, 52, 54, 05 Nov. 2012
(公社)日本放射線技術学会-北海道支部, Japanese

運動器疾患の画像診断 III.MRI診断 5.椎間板障害に対するMRI MRIによる椎間板変性度とT2緩和時間の関係
高島弘幸, 竹林庸雄, 山下敏彦, 別冊整形外科, 1, 62, 119, 123, 25 Oct. 2012
MRIによる椎間板変性度分類は、PfirmannらによるT2強調画像を用いた分類法が知られているが、この方法は視覚による主観的評価であるため定量性に欠けるという問題点がある。一方、最近のMRIでは様々な機能的画像法が研究され、なかでもT2マップは水分含有量をT2緩和時間(以下T2値)で定量化することが可能なことから、軟骨病変の早期検出や治療効果判定などに用いられている。さらにT2値は椎間板のプロテオグリカン含有量も反映すると報告されていることから、椎間板のT2値を計測することで椎間板の生理的変化や変性を定量的に評価できる可能性がある。そこで今回、主観的評価であるPfirmann分類をT2マップによって定量化し、客観的評価に基づく分類の構築を試みた。方法は、腰痛や下肢痛のため腰椎MRIを撮像された50例の画像を資料とし、放射線科専門医がL1/L2～L5/S1の椎間板変性度をPfirmannらの方法に従ってgrade I～Vに分類するとともに、L1/L2～L5/S1のT2値を計測し、gradeごとのT2平均値を算出した。T2値の計測部位は「前方線維輪」「髄核」「後方線維輪」の3ヶ所とした。このうち「髄核」のT2値はgradeの進行に伴って低下傾向を示し、grade I～IVの各grade間には有意差が認められた。「前方線維輪」と「後方線維輪」のT2値はgrade間の有意差を認めなかった。, (株)南江堂, Japanese

腰椎椎間板ヘルニアにおける下肢痛とMRI拡散係数の関連について
高島弘幸, 竹林庸雄, 吉本三徳, 井田和功, 谷本勝正, 山下敏彦, 日本運動器疼痛学会誌, 4, 2, 69, 15 Oct. 2012
Japanese

トモシンセシスによる距骨下関節ストレス撮影
寺本篤史, 渡邉耕太, 小林拓馬, 高島弘幸, 赤塚吉紘, 山下敏彦, 日本足の外科学会雑誌, 33, 2, S152, S152, 15 Sep. 2012
(一社)日本足の外科学会, Japanese

トモシンセシスを用いた遠位脛腓靭帯結合荷重撮影
寺本篤史, 高島弘幸, 渡邉耕太, 木井雄一郎, 小林拓馬, 山下敏彦, 日本整形外科スポーツ医学会雑誌, 32, 4, 409, 409, 31 Aug. 2012
(一社)日本整形外科スポーツ医学会, Japanese

拡散強調画像を用いた椎間板ヘルニアにおける障害神経の解析
高島弘幸, 竹林庸雄, 吉本三徳, 寺島嘉紀, 井田和功, 宍戸博紀, 今村塁, 赤塚吉紘, 山下敏彦, 日本整形外科学会雑誌, 86, 8, S1358, 25 Aug. 2012
Japanese

トモシンセシスを用いた遠位脛腓靭帯結合荷重撮影
寺本篤史, 高島弘幸, 渡邉耕太, 木井雄一郎, 小林拓馬, 山下敏彦, JOSKAS, 37, 4, 310, 310, 11 Jun. 2012
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

人工膝関節大腿骨コンポーネント回旋設置評価におけるトモシンセシスの有用性
小路弘晃, 寺本篤史, 高島弘幸, 渡邉耕太, 佐藤直一, 木井雄一郎, 工藤未来, 大坪英則, 山下敏彦, JOSKAS, 37, 4, 104, 104, 11 Jun. 2012
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

腰椎椎体間固定術術後の骨癒合評価におけるトモシンセシスとCTの比較
高島弘幸, 竹林庸雄, 千葉彩佳, 瀧川明宏, 宍戸博紀, 今村塁, 赤塚吉紘, 佐藤順一, 虻川雅基, 大元秀近, 本間修一, 杉本晴美, 北海道放射線技術雑誌, 72, 18, 19, 29 Mar. 2012
Japanese

トモシンセシスにおける断層厚に関する検討
千葉彩佳, 高島弘幸, 瀧川明宏, 宍戸博紀, 今村塁, 赤塚吉紘, 佐藤順一, 虻川雅基, 北海道放射線技術雑誌, 72, 16, 17, 29 Mar. 2012
Japanese

MRI拡散強調画像を用いた腰椎椎間板ヘルニアにおける障害神経の解析
高島弘幸, 竹林庸雄, 吉本三徳, 井田和功, 寺島嘉紀, 山下敏彦, J Spine Res, 3, 3, 258, 25 Mar. 2012
Japanese

1.5Tと3.0TにおけるMagic angle effectの検証
赤塚吉紘, 宍戸博紀, 今村塁, 千葉彩佳, 瀧川明宏, 高島弘幸, 長濱宏史, 白勢竜二, 原田邦明, 北海道放射線技術雑誌, 72, 72, 22, 23, Mar. 2012
(公社)日本放射線技術学会-北海道支部, Japanese

3point‐Dixon法を用いた脂肪含有率算出に関する最適撮像条件の検討
今村塁, 高島弘幸, 宍戸博紀, 赤塚吉紘, 長濱宏史, 原田邦明, 櫻井佑樹, 千葉彩佳, 瀧川明宏, 白勢竜二, 北海道放射線技術雑誌, 72, 72, 20, 21, Mar. 2012
(公社)日本放射線技術学会-北海道支部, Japanese

腰部神経根描出のための3D MRI撮像法の検討
宍戸博紀, 高島弘幸, 今村塁, 赤塚吉紘, 千葉彩佳, 長濱宏史, 白勢竜二, 瀧川明宏, 原田邦明, 北海道放射線技術雑誌, 72, 72, 12, 13, Mar. 2012
(公社)日本放射線技術学会-北海道支部, Japanese

トモシンセシスによる人工膝関節置換術術後の大腿骨上顆軸撮影法の検討
赤塚吉紘, 高島弘幸, 千葉彩佳, 宍戸博紀, 今村塁, 瀧川明宏, 佐藤順一, 日本放射線技術学会総会学術大会予稿集, 68th, 252, 29 Feb. 2012
Japanese

腰部神経根(病変)描出のための3D MRI撮像法の検討と有用性
宍戸博紀, 高島弘幸, 今村塁, 赤塚吉宏, 千葉彩佳, 瀧川明宏, 原田邦明, 日本放射線技術学会総会学術大会予稿集, 68th, 227, 228, 29 Feb. 2012
Japanese

トモシンセシスにおけるX線管球走査方向と描出能の関係
千葉彩佳, 高島弘幸, 宍戸博紀, 今村塁, 赤塚吉紘, 瀧川明宏, 佐藤順一, 日本放射線技術学会総会学術大会予稿集, 68th, 110, 111, 29 Feb. 2012
Japanese

骨格筋の画像評価 最前線―生涯を通じたアクティブライフのために―II 骨格筋の画像評価法最前線 2.MRS MRスペクトロスコピー(MRS)がもたらす情報―¹H‐MRSによる筋内脂肪量の半定量的評価を中心に
高島弘幸, 栗原俊之, Innervision, 27, 3, 34, 36, 25 Feb. 2012
MRスペクトロスコピー(MRS)は、生体内に存在する代謝物質を非侵襲的に検出できる手段として着目されている。特に、水素原子(プロトン)の化学シフトを利用した1H-MRS(プロトン磁気共鳴分光法)は、水素原子が生体内に大量に含まれていることから、他の核種のMRSに比べて検出感度が高く、通常のイメージングコイルで信号を検出できることや、任意の関心領域からのみの信号を検出できることなどの利点があり、数多くの研究が行われてきた。例えば、脳神経領域では、N-アスパラギン酸(NAA)や乳酸、コリンなどの代謝物質が検出できることで、脳虚血や脳腫瘍のシグナルとして臨床応用されつつある。筋肉の場合には、筋内に含まれる重要な代謝物質として乳酸、クレアチン、アデノシン三リン酸(ATP)やアデノシン二リン酸(ADP)などが挙げられるが、骨格筋に1H-MRSを用いると、骨格筋内部に多く含まれる水と脂肪のスペクトルが大きく検出されてしまう。そのため骨格筋では、上記の代謝物質を調べるために1H-MRSよりも、リン酸31P-MRS(37～40頁参照)やグルコース13C-MRSを使うことが多い。しかしながら、代謝物の信号を検出するために水抑制を用いることによって、骨格筋細胞内に脂肪滴として存在する細胞内脂肪(intramyuocellular lipids:IMCL)と、皮下脂肪や筋線維に沿って筋線維間脂肪細胞として存在する細胞外脂肪(extramyocellular lipids:EMCL)を分離して検出できると、Boeschらにより報告されてからは、骨格筋に1H-MRSを用いた研究が増えてきた。(著者抄録), (株)インナービジョン, Japanese

MRIによる椎間孔外病変の診断に関する検討
高島弘幸, 宍戸博紀, 今村塁, 赤塚吉紘, 竹林庸雄, 吉本三徳, 井田和功, 寺島嘉紀, 山下敏彦, 北海道整形災害外科学会, 122nd, 66, 2012
Japanese

トモシンセシスを用いた遠位脛腓靭帯結合荷重撮影
寺本篤史, 渡邉耕太, 木井雄一郎, 小林拓馬, 山下敏彦, 高島弘幸, 北海道整形災害外科学会, 122nd, 4, 82, 310, 2012
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

Computed tomographyを用いた後頭骨の解剖学的研究
森田智慶, 竹林庸雄, 吉本三徳, 井田和功, 谷本勝正, 黄金勲矢, 村田憲治, 山下敏彦, 高島弘幸, 北海道整形災害外科学会, 123rd, 19, 2012
Japanese

トモシンセシスによる距骨下関節ストレス撮影
寺本篤史, 渡邉耕太, 小林拓馬, 山下敏彦, 高島弘幸, 赤塚吉紘, 北海道整形災害外科学会, 123rd, 2, 17, S152, 2012
(一社)日本足の外科学会, Japanese

¹H MR Spectroscopyによる筋負荷時の代謝物変化
高島弘幸, 宍戸博紀, 赤塚吉紘, 今村塁, 竹林庸雄, 山下敏彦, 北海道整形災害外科学会, 123rd, 50, 2012
Japanese

MRI T2mappingによる腰椎alignmentと椎間板変性に関する検討
高島弘幸, 竹林庸雄, 吉本三徳, 井田和功, 寺島嘉紀, 山下敏彦, 北海道整形災害外科学会, 122nd, 65, 2012
Japanese

人工膝関節大腿骨コンポーネント回旋設置評価におけるトモシンセシスの有用性
寺本篤史, 小路弘晃, 渡邉耕太, 佐藤直一, 木井雄一郎, 工藤未来, 大坪英則, 山下敏彦, 高島弘幸, 北海道整形災害外科学会, 122nd, 4, 76, 104, 2012
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

腰椎椎体間固定術後の骨癒合評価におけるトモシンセシスの有用性について
高島弘幸, 瀧川明宏, 宍戸博紀, 今村塁, 赤塚吉紘, 千葉彩佳, 佐藤順一, 北海道放射線技術雑誌, 71, 113, 25 Oct. 2011
Japanese

トモシンセシスにおける断層厚に関する検討
千葉彩佳, 高島弘幸, 宍戸博紀, 瀧川明宏, 今村塁, 赤塚吉紘, 佐藤順一, 北海道放射線技術雑誌, 71, 112, 25 Oct. 2011
Japanese

1.5Tと3.0TにおけるMagic angle effectの検証
赤塚吉紘, 宍戸博紀, 高島弘幸, 今村塁, 千葉彩佳, 瀧川明宏, 北海道放射線技術雑誌, 71, 109, 25 Oct. 2011
Japanese

腰部神経根(病変)描出のための3D MRI撮像法の検討
宍戸博紀, 高島弘幸, 今村塁, 赤塚吉紘, 千葉彩佳, 瀧川明宏, 北海道放射線技術雑誌, 71, 108, 25 Oct. 2011
Japanese

3point‐Dixon法を用いた脂肪含有率算出に関する最適撮像条件の検討
今村塁, 高島弘幸, 宍戸博紀, 赤塚吉紘, 瀧川明宏, 千葉彩佳, 原田邦明, 北海道放射線技術雑誌, 71, 121, 25 Oct. 2011
Japanese

3Tesla MRIによる頚髄の拡散テンソル解析
高島弘幸, 竹林庸雄, 寺島嘉紀, 吉本三徳, 山下敏彦, 日本整形外科学会雑誌, 85, 8, S1294, 25 Aug. 2011
Japanese

3T MRIによる頚髄の拡散テンソル解析
高島弘幸, 竹林庸雄, 吉本三徳, 津田肇, 寺島嘉紀, 山下敏彦, J Spine Res, 2, 3, 530, 25 Mar. 2011
Japanese

股関節唇損傷における放射状MRIと鏡視下手術所見の比較
赤塚吉紘, 高島弘幸, 白勢竜二, 小倉圭史, 宍戸博紀, 櫻井佑樹, 今村塁, 日本放射線技術学会総会学術大会予稿集, 67th, 108, 25 Feb. 2011
Japanese

荷重および非荷重時における膝関節半月板T2mapの評価
宍戸博紀, 高島弘幸, 白勢竜二, 小倉圭史, 今村塁, 櫻井佑樹, 赤塚吉紘, 日本放射線技術学会総会学術大会予稿集, 67th, 110, 25 Feb. 2011
Japanese

逐次近似法を応用したNoise Consistency Methodの開発
原田耕平, 小倉圭史, 高島弘幸, 本間修一, 長濱宏史, 今村塁, 瀬川晃司, 日本放射線技術学会総会学術大会予稿集, 67回, 302, 302, Feb. 2011
(公社)日本放射線技術学会, Japanese

3T MRIによる頚髄の拡散テンソル解析
高島弘幸, 竹林庸雄, 吉本三徳, 津田肇, 寺島嘉紀, 山下敏彦, 北海道整形災害外科学会, 120th, 32, 2011
Japanese

拡散強調画像を用いた椎間板ヘルニアにおける障害神経の解析
高島弘幸, 竹林庸雄, 吉本三徳, 寺島嘉紀, 井田和功, 山下敏彦, 北海道整形災害外科学会, 121st, 2, 2011
Japanese

3D FIESTA‐CによるBPASの有用性
須藤洋平, 原田邦明, 白勢竜二, 高島弘幸, 長濱宏史, 笹川純市, 北海道放射線技術雑誌, 70, 70, 21, 23, Jul. 2010
3D FIESTA-Cを用いBPASを撮像し(3D FIESTA-C BPAS)、従来のBPAS(2D FRFSE BPAS)との比較検討を行い、臨床上の有用性について検討した。健常人5例と臨床例2例において2D FRFSE BPASと3D FIESTA-C BPASを2種類撮像した。臨床例では、脳実質を見ると2D FRFSE BPASでは信号が高く3D FIESTA-C BPASでは信号が低いという違いは見られるが、椎骨脳底動脈やその周囲のCSFに注目すると信号に大きな差は見られなかった。2例の健常人では3D FIESTA-C BPASは2D FRFSE BPASに比べてそれぞれ約44%、26%CNRが低下した。他の健常人においては、ほぼ同等のCNRとなった。, (公社)日本放射線技術学会-北海道支部, Japanese

多時相FAIR法による脳血流動態の可視化
長濱宏史, 原田邦明, 白勢竜二, 高島弘幸, 櫻井佑樹, 赤塚吉紘, 笹川純市, 北海道放射線技術雑誌, 70, 70, 1, 5, Jul. 2010
複数の一定時間(TI)のFAIR(多時相FAIR法)を撮像することで脳血流動態の可視化を試み、多時相FAIR法の撮像条件の最適化を行った。健常ボランティアにおける多時相FAIR画像では、TIの変化に伴って血流が流入し、流出していく様子が描出された。Broad IR Volumeによる多時相FAIR画像では動脈血が流入し続ける画像となった。TIの変化に伴う信号強度(CBF値)の変化を被殻にROIをとって計測した。Narrow IR Volumeによる多時相FAIRはあるTIまでは信号が上昇し、さらに長いTIでは信号強度が下がっていった。Broad IR Volumeでは信号強度が上昇し続けた。複数のTIを取得することで虚血による血流低下であるか、もしくは動脈血の流入遅延によるみかけの血流低下であるかを判別することが可能であり、臨床応用が期待できることが示唆された。, (公社)日本放射線技術学会-北海道支部, Japanese

MRI T2 mappingによる腰椎椎間板変性度分類
高島弘幸, 竹林庸雄, 吉本三徳, 津田肇, 山下敏彦, 日本整形外科学会雑誌, 84, 4, S436, 25 Apr. 2010
Japanese

Psoas‐relaxed positionは腰椎の前弯を減少させない
大島雄一郎, 吉本三徳, 岩瀬岳人, 竹林庸雄, 津田肇, 濱田一範, 山下敏彦, 高島弘幸, 日本整形外科学会雑誌, 84, 4, S438, 25 Apr. 2010
Japanese

脊椎・脊髄イメージング―標準的検査法から最新情報まで 第1章:画像検査法編 2.脊椎脊髄における画像診断技術の最近の進歩 拡散強調画像
玉川光春, 山下敏彦, 高島弘幸, 脊椎脊髄ジャーナル, 23, 4, 281, 285, 25 Apr. 2010
(株)三輪書店, Japanese

psoas‐relaxed positionは腰椎の前弯を減少させない
大島雄一郎, 吉本三徳, 岩瀬岳人, 竹林庸雄, 津田肇, 濱田一範, 山下敏彦, 高島弘幸, J Spine Res, 1, 3, 658, 25 Mar. 2010
Japanese

MRI T2 mappingによる椎間板変性度分類
高島弘幸, 竹林庸雄, 吉本三徳, 津田肇, 井田和功, 山下敏彦, J Spine Res, 1, 3, 660, 25 Mar. 2010
Japanese

Instant‐fMRI2における至適撮像条件の検討
赤塚吉紘, 原田邦明, 高島弘幸, 長濱宏史, 櫻井佑樹, 須藤洋平, 篠崎淳, 日本放射線技術学会総会学術大会予稿集, 66回, 188, 188, Feb. 2010
(公社)日本放射線技術学会, Japanese

Multi TI FAIR法による脳血流動態の視覚化
長濱宏史, 原田邦明, 白勢竜二, 高島弘幸, 櫻井佑樹, 須藤洋平, 坂田元道, 日本放射線技術学会総会学術大会予稿集, 66回, 185, 185, Feb. 2010
(公社)日本放射線技術学会, Japanese

椎骨動脈解離に対する3D FIESTA BPASの有用性
須藤洋平, 原田邦明, 白勢竜二, 高島弘幸, 長濱宏史, 笹川純市, 日本放射線技術学会総会学術大会予稿集, 66回, 192, 192, Feb. 2010
(公社)日本放射線技術学会, Japanese

Instant‐fMRIにおけるBrainWave PAとSPMの比較
櫻井佑樹, 原田邦明, 高島弘幸, 長濱宏史, 赤塚吉紘, 須藤洋平, 篠崎淳, 日本放射線技術学会総会学術大会予稿集, 66回, 187, 188, Feb. 2010
(公社)日本放射線技術学会, Japanese

荷重条件3D‐MRIを用いた術前半月板損傷診断の試み
鈴木智之, 渡邉耕太, 箕輪剛, 武田真太郎, 木村重治, 山下敏彦, 大坪英則, 高島弘幸, 北海道整形災害外科学会, 118th, 31, 2010
Japanese

MRI T2 mappingによる腰椎変性すべり因子の解析
高島弘幸, 竹林庸雄, 吉本三徳, 井田和功, 山下敏彦, 日本整形外科学会雑誌, 83, 8, S1276, 25 Aug. 2009
Japanese

脛骨骨軟骨腫により膝のロッキングをきたした1例
岡田葉平, 箕輪剛, 倉秀治, 渡邉耕太, 大坪英則, 高島弘幸, 山下敏彦, 膝, 33, 2, 403, 406, 30 Apr. 2009
23歳女。しゃがんだ状態から立ち上がる際、右膝内側部に激痛を自覚し右膝伸展不能となった。疼痛・伸展障害が改善しないため、受診した。右膝はロッキングしており、鵞足部に圧痛を認めた。疼痛が強いため、圧痛部に1%リドカインを局所注射したのち、他動的に膝を屈曲・伸展させると、ロッキングは解除された。可動域制限は改善されたが、膝深屈曲から伸展する際鵞足部でのスナッピングは残存した。術前情報より、半腱様筋腱がスナッピングの原因と考え手術を行った。単純レントゲン像上、腫瘍の取り残しは無く、疼痛は消失した。術後1年の現在、スナッピング及び疼痛は再発していない。, 日本膝関節学会, Japanese

Locking knee induced by a tibial Osteochondroma
OKADA Yohei, MINOWA Takeshi, KURA Hideji, WATANABE Kota, OOTSUBO Hidenori, TAKASHIMA Hiroyuki, YAMASHITA Toshihiko, 膝 = The knee, 33, 2, 403, 406, 30 Apr. 2009
Japanese

MRI拡散強調画像による腰部神経根の評価
高島弘幸, 竹林庸雄, 井田和功, 吉本三徳, 山下敏彦, 日本脊椎脊髄病学会雑誌, 20, 2, 596, 20 Mar. 2009
Japanese

far‐out syndromeにおけるL5神経根造影後CTの有用性
阿部恭久, 吉本三徳, 竹林庸雄, 井田和功, 岩瀬岳人, 平野章, 高島弘幸, 山下敏彦, 日本脊椎脊髄病学会雑誌, 20, 2, 594, 20 Mar. 2009
Japanese

3.0T FAIRにおける加算回数の検討
長濱宏史, 原田邦明, 鈴木淳平, 白勢竜二, 高島弘幸, 櫻井佑樹, 日本放射線技術学会総会学術大会予稿集, 65th, 171, 172, 27 Feb. 2009
Japanese

拡散強調画像による腰部神経根の評価
高島弘幸, 竹林庸雄, 原田邦明, 白勢竜二, 鈴木淳平, 長濱宏史, 笹川純市, 日本放射線技術学会総会学術大会予稿集, 65th, 130, 27 Feb. 2009
Japanese

T2 mapによる腰椎変性辷り因子の基礎的検討
高島弘幸, 玉川光春, 原田邦明, 白勢竜二, 鈴木淳平, 長濱宏史, 櫻井佑樹, 日本放射線技術学会総会学術大会予稿集, 65th, 217, 27 Feb. 2009
Japanese

3T脳血管MRAにおける0.4mm voxel撮像の有用性
原田邦明, 白勢竜二, 高島弘幸, 鈴木淳平, 長濱宏史, 櫻井佑樹, 笹川純市, 日本放射線技術学会総会学術大会予稿集, 65th, 174, 27 Feb. 2009
Japanese

3T MRIを用いた3D TOF MRAのVR画像作成におけるしきい値処理の最適化
鈴木淳平, 原田邦明, 白勢竜二, 高島弘幸, 長濱宏史, 笹川純市, 日本放射線技術学会総会学術大会予稿集, 65th, 173, 27 Feb. 2009
Japanese

三次元CTを用いた肩峰下骨棘の局在と形態についての検討
上野栄和, 岡村健司, 廣瀬聰明, 高島弘幸, 水野諭, 村瀬正樹, 山下敏彦, 日本整形外科学会雑誌, 83, 2, S165, 25 Feb. 2009
Japanese

MRI T2mappingによる腰椎椎間板変性度分類
高島弘幸, 竹林庸雄, 吉本三徳, 津田肇, 山下敏彦, 井田和功, 北海道整形災害外科学会, 117th, 8, 2009
Japanese

MRI拡散強調画像による腰部神経根の評価
高島弘幸, 竹林庸雄, 吉本三徳, 井田和功, 山下敏彦, 北海道整形災害外科学会, 116th, 55, 2009
Japanese

腰椎変性辷り症のMRI T2mappingによる解析
高島弘幸, 竹林庸雄, 吉本三徳, 津田肇, 山下敏彦, 井田和功, 北海道整形災害外科学会, 117th, 7, 2009
Japanese

far‐out syndromeにおけるL5神経根造影後CTの有用性
阿部恭久, 吉本三徳, 竹林庸雄, 井田和功, 岩瀬岳人, 平野章, 山下敏彦, 高島弘幸, 北海道整形災害外科学会, 116th, 54, 2009
Japanese

3T MRIによる頭部領域の高精細画像
原田 邦明, 白勢 竜二, 高島 弘幸, 鈴木 淳平, 長濱 宏史, 蝶野 大樹, 桜井 佑樹, 笹川 純市, 映像情報Medical, 40, 14, 121, 127, Dec. 2008
産業開発機構(株), Japanese

腱板断裂患者の肩峰下骨棘の形態
上野栄和, 岡村健司, 廣瀬聰明, 高島弘幸, 水野諭, 村瀬正樹, 肩関節, 33, 1, 125, 01 Oct. 2008
Japanese

脛骨骨軟骨腫により膝のロッキングをきたした1例
岡田葉平, 箕輪剛, 渡邉耕太, 大坪英則, 大木豪介, 佐々木幹人, 山下敏彦, 倉秀治, 平野透, 高島弘幸, 北海道整形災害外科学会雑誌, 50, 1, 148, 29 Aug. 2008
Japanese

MRI拡散強調像による腰部神経根の評価
高島弘幸, 竹林庸雄, 吉本三徳, 原田邦明, 白勢竜二, 山下敏彦, 日本整形外科学会雑誌, 82, 8, S935, 25 Aug. 2008
Japanese

MRI Evolution 2008 関節領域における3T MRIの知見と今後の展望
高島弘幸, 原田邦明, 白勢竜二, 鈴木淳平, 長濱宏史, 笹川純市, Rad Fan, 6, 9, 37, 39, Aug. 2008
(株)メディカルアイ, Japanese

腱板断裂患者の肩峰下骨棘の形態
上野栄和, 岡村健司, 廣瀬聰明, 高島弘幸, 山下敏彦, 北海道整形災害外科学会, 115th, 43, 2008
Japanese

肩峰下骨棘の局在と形態の検討
上野栄和, 岡村健司, 廣瀬聰明, 野中伸介, 舘田健児, 山下敏彦, 高島弘幸, 北海道整形災害外科学会, 114th, 37, 2008
Japanese

MRI of necrotizing fasciitis in the lower extremities; three cases
TAKASHIMA HIROYUKI, MINAGI YASUHIKO, SUGIMOTO TADASHI, NAMBU TOSHIKAZU, YAMASHITA JUN, HOKIN SHUICHI, UENO HIROO, WATANABE NAOKI, 北海道整形災害外科学会雑誌, 48, 2, 49, 53, 20 Mar. 2007
壊死性筋膜炎は主に連鎖球菌により発症する致死率の高い重症軟部組織感染症である。今回筆者らは、迅速なMRI検査及び外科的治療により、救命できた3例の下肢壊死性筋膜炎を経験したので、MRI所見について報告する。3例に共通するMRI所見は、皮下脂肪織の網状パターン、筋膜に沿って液貯留を示唆するT1強調像で低信号、T2強調像で高信号領域の存在であった。またGd造影後脂肪抑制T1強調像は皮下組織および筋膜の炎症範囲が推定でき、外科的治療に有用であった。Gd造影後脂肪抑制T1強調像の撮像において、感染部位の拡大を把握できるよう、撮像範囲を近位を含めて広く設定する必要があると考えた。(著者抄録), 北海道整形災害外科学会, Japanese

肝腫瘍に対するCT経時・造影差分の臨床応用への可能性に関する検討
阿部善行, 渡辺直輝, 高島弘幸, 南部敏和, 富田伸生, 大浦大輔, 守屋禎之, 日本放射線技術学会総会学術大会予稿集, 63rd, 177, 20 Feb. 2007
Japanese

How to Adjust the MRI Parameters
NOBUTA SHUICHI, HARADA KUNIAKI, KAWASAKI SHIN'ICHI, MORIYAMA KENJI, YASUDA KOJI, UENO MASAYUKI, TAKASHIMA HIROYUKI, 日本放射線技術学会雑誌, 63, 7, 796-805 (J-STAGE), 805, 2007
(Article in Japanese), Japanese Society of Radiological Technology (JSRT), Japanese

2D‐TOF法における基礎的検討―流速とTEの関係―
高島弘幸, 渡辺直輝, 阿部善行, 原田邦明, 白勢竜二, 小倉圭史, 日本放射線技術学会雑誌, 62, 9, 1220, 1220, 20 Sep. 2006
公益社団法人日本放射線技術学会, Japanese

CT/MRI画像における差分画像処理法の検討
阿部善行, 高島弘幸, 渡辺直輝, 南部敏和, 富田伸生, 大浦大輔, 宝金秀一, 守屋禎之, 日本放射線技術学会雑誌, 62, 9, 1266, 1266, 20 Sep. 2006
公益社団法人日本放射線技術学会, Japanese

胸腹部CTにおける経時差分画像処理の試み
大浦大輔, 南部敏和, 富田伸生, 宝金秀一, 渡辺直輝, 高島弘幸, 阿部善行, 守屋禎之, 日本放射線技術学会雑誌, 62, 9, 1265, 1266, 20 Sep. 2006
公益社団法人日本放射線技術学会, Japanese

MRI画像における差分画像処理の試み
富田伸生, 南部敏和, 大浦大輔, 宝金秀一, 渡辺直輝, 高島弘幸, 阿部善行, 守屋禎之, 日本放射線技術学会雑誌, 62, 9, 1266, 20 Sep. 2006
Japanese

311 胸腹部CTにおける経時差分画像処理の試み(画像工学 経時的差分法1,一般研究発表,日本放射線技術学会 第34回秋季学術大会)
大浦 大輔, 南部 敏和, 富田 伸生, 宝金 秀一, 渡辺 直輝, 高島 弘幸, 阿部 善行, 守屋 禎之, 日本放射線技術學會雜誌, 62, 9, 1265, 1266, 20 Sep. 2006
公益社団法人日本放射線技術学会, Japanese

312 MRI画像における差分画像処理の試み(画像工学 経時的差分法1,一般研究発表,日本放射線技術学会 第34回秋季学術大会)
富田 伸生, 南部 敏和, 大浦 大輔, 宝金 秀一, 渡辺 直輝, 高島 弘幸, 阿部 善行, 守屋 禎之, 日本放射線技術學會雜誌, 62, 9, 1266, 1266, 20 Sep. 2006
公益社団法人日本放射線技術学会, Japanese

314 CT/MRI画像における差分画像処理法の検討(画像工学 経時的差分法1,一般研究発表,日本放射線技術学会 第34回秋季学術大会)
阿部 善行, 高島 弘幸, 渡辺 直輝, 南部 敏和, 富田 伸生, 大浦 大輔, 宝金 秀一, 守屋 禎之, 日本放射線技術學會雜誌, 62, 9, 1266, 1266, 20 Sep. 2006
公益社団法人日本放射線技術学会, Japanese

115 2D-TOF法における基礎的検討 : 流速とTEの関係(MR検査 画像解析,一般研究発表,日本放射線技術学会 第34回秋季学術大会)
高島 弘幸, 渡辺 直輝, 阿部 善行, 原田 邦明, 白勢 竜二, 小倉 圭史, 日本放射線技術學會雜誌, 62, 9, 1220, 1220, 20 Sep. 2006
公益社団法人日本放射線技術学会, Japanese

MR Imaging of Necrotizing Fasciitis in the Lower Extremities
TAKASHIMA Hiroyuki, NAMBU Toshikazu, YAMASHITA Jun, UENO Hiroo, WATANABE Naoki, HOUKIN Shuuichi, 日本磁気共鳴医学会雑誌, 26, 2, 128, 134, 15 Apr. 2006
壊死性筋膜炎の3例を経験した.症例1(57歳男).右下腿から大腿遠位部の蜂窩織炎,液貯留を伴った筋膜炎と診断し,大腿遠位部から下腿の緊急デブリードマンおよび病理組織診断を施行した.大腿遠位部の皮膚発赤はさらに上方に拡大してきたため,大腿切断術を施行し,その後は順調に経過した.症例2(56歳男).左大腿近位～下腿および足関節の広範囲デブリードマン,筋膜切除,第4・5趾切断術を施行した.その後は順調に経過,3ヵ月後に退院となった.症例3(30歳,女).大腿遠位以下のデブリードマン,筋膜切除術を施行したが,大腿部の発赤はさらに拡大し,右大腿中央からの切断と大腿上部のデブリードマンを追加施行した.さらに肉眼的には正常に見える部分でもMRI上,増強を認めらていた右鼠径部付近も感染所見を確認し,筋膜切除を行った.創洗浄,抗菌療法を継続し,改善傾向を示した, (一社)日本磁気共鳴医学会, Japanese

EPI‐TOF法を用いた非造影MR‐Venographyの試み
高島弘幸, 松本孝俊, 京野伸郎, 北山明雄, 諏訪亨, 日本放射線技術学会総会学術大会予稿集, 61st, 150, 151, 20 Feb. 2005
Japanese

下肢静脈疾患における造影MR‐Venography描出能の検討
高島弘幸, 渡辺直輝, 日本放射線技術学会総会学術大会予稿集, 60th, 94, 20 Feb. 2004
Japanese

Basic study of T1-weighted images with fat suppression
TAKASHIMA HIROYUKI, TOMITA NOBUO, HIRANO YUJI, 北海道放射線技術雑誌, 63, 63, 1, 9, 31 Jul. 2003
脂肪抑制併用Spoiled gradient echo法においてGd造影剤の信号強度および脂肪抑制効果について検討した.異なる濃度のGd-DTPA水溶液とオリーブ油を用いたファントムを作成し,それぞれの基本撮像条件からFlip angleを変化させて実験を行った.Gd-DTPA水溶液の濃度と信号強度は相関し,今回のようなTR,TE設定した場合の各パルスシークエンスと脂肪抑制方法およびそれぞれに最適なFlip angleを求めることができた.脂肪抑制効果のもっとも大きな組み合わせはT1FFE-ProSet1331,T1FFEEPI-ProSet1331であったが,ProSetの使用はTEの延長を伴うため,注意を要した.1.0T装置においてMR angiographyではTEが短いT1TFE-SPIRが,Dynamic MRIでは撮像部位による脂肪抑制効果が大きいT1FFEEPI-SPIRが最適と考えられた, (公社)日本放射線技術学会-北海道支部, Japanese

脂肪抑制併用超高速シーケンスの基礎的検討
高島弘幸, 日本放射線技術学会雑誌, 58, 9, 1154, 1155, 20 Sep. 2002
公益社団法人 日本放射線技術学会, Japanese

64 脂肪抑制併用超高速シーケンスの基礎的検討(第30回秋季学術大会 一般研究発表予稿集)
高島 弘幸, 日本放射線技術學會雜誌, 58, 9, 1154, 1155, 20 Sep. 2002
公益社団法人日本放射線技術学会, Japanese

Enhanced MR Angiography of the Lower Extremities with Synergy Spine Coil.
TAKASHIMA HIROYUKI, WATANABE NAOKI, 北海道放射線技術雑誌, 62, 62, 73, 78, 28 Jun. 2002, [Lead author, Corresponding author]
National Electrical Manufacturers Association(NEMA)standardの特殊RFコイルの特性評価法に準じファントム実験を行い,感度領域を測定した.その結果,wholebody coilと比較した場合のsynergy spine coilの撮像有効範囲を求めることができた.有効な感度領域はX軸方向300mm,Y軸方向120mm,Z軸方向は使用element数を変化させることにより,必要とされる任意の広さに設定できた.以上より,下肢,特に下腿部造影MR-angiographyでは,多くの症例においてポジショニングが可能であり,whole body coilを用いるよりもsignal-to-Noise Ratio(SNR)が向上するためよりよい画像を得ることができ,synergy spine coilの使用は有効であると思われた, (公社)日本放射線技術学会-北海道支部, Japanese

ミトコンドリア機能および筋細胞内脂肪に着目した疼痛発生メカニズムの解明
科学研究費助成事業 基盤研究(C)
01 Apr. 2023 - 31 Mar. 2028
高島 弘幸
日本学術振興会, 基盤研究(C), 北海道大学, 23K08645

Investigation of mechanism of pain generation focusing on the relationship between muscle adipose tissue and inflammatory cytokines
Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
01 Apr. 2018 - 31 Mar. 2021
Takashima Hiroyuki
Previous studies have reported the relationship between low back pain (LBP) and fat degeneration or atrophy in the paraspinal muscles. We applied MR spectroscopy to the investigation of LBP. We compared intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) in paraspinal muscles between asymptomatic volunteers and LBP patients and reported that IMCL in Mm of patients with LBP was higher than that in Mm of asymptomatic volunteers. However, there were no fundamental studies investigating relationship between IMCL and pain. To investigate the relationship between pain and IMCL, we considered that it was essential to develop animal model indicating increasing IMCL. This study results that there was significant decrease of IMCL using tail-suspended combined with hind-limbs-casted rat model. Tail-suspended combined with casted rat model enables to use as rat model showing decrease of IMCL.
Japan Society for the Promotion of Science, Grant-in-Aid for Early-Career Scientists, Sapporo Medical University, 18K16667

Evaluation of neuromuscular disease activity by diffusion tensor imaging
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
2010 - 2013
HATAKENAKA Masamitsu, TAKASHIMA Hiroyuki, TMATSUO Yoshio, OHYAGI Yasumasa, SAKAE Nobutaka, NISHIKAWA Kei, HONDA Hiroshi, SUNAMI Shunya, KAMITANI Takeshi
The fractional anisotropy of myopathy lesion was decreased by 38%, and lambuda 1, 2, and 3 were increased by 59%, 69%, and 79% compared to normal muscles, respectively. These results suggest that parameters related to diffusion tensor imaging are useful for detecting myopathy lesions. However, when comparing absolute parameter values and setting thresholds, some attentions are needed regarding the MR system characteristics.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), 九州大学->札幌医科大学, Coinvestigator not use grants, Competitive research funding, 22591341