論文

• Effectiveness of McGRATH MAC Video Laryngoscopy for First-Attempt Intubation by Anesthesia Trainees in Infants: A Randomized Controlled Trial.
  Yuka Uchinami, Noriaki Fujita, Koji Hoshino, Yasunori Kubo, Yasunori Yagi, Masatoshi Shoji, Isao Yokota, Yuji Morimoto
  Anesthesia and analgesia, 2026年02月16日, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Tracheal intubation in infants poses unique anatomical and physiological challenges and is particularly difficult for anesthesia trainees. Video laryngoscopy has been suggested to improve intubation success, yet evidence among novice providers remains limited. We aimed to evaluate whether anesthesia trainees had a higher first-attempt success rate for tracheal intubation in infants using traditional direct laryngoscopy (DL) with a Miller or Macintosh blade, or indirect video laryngoscopy with a McGrath video laryngoscope size 1 Macintosh blade (McGrath VL). METHODS: In this single-center, parallel-group, randomized controlled trial, infants (<1-year-old) scheduled for elective surgery requiring orotracheal intubation were randomly allocated to either McGrath VL or DL. All intubations were performed by anesthesia trainees under supervision. The primary outcome was the first-attempt intubation success rate. Secondary outcomes included intubation difficulty score, glottic visualization, time to intubation, and intubation-related complications. RESULTS: Between October 2021 and February 2024, 124 infants were enrolled and randomized (McGrath VL: n = 61; DL: n = 63). First-attempt success was achieved in 53/61 (86.9%) in the McGrath VL group and 47/63 (74.6%) in the DL group (risk difference 16.5%, 95% confidence interval [CI],3.0%-29.9%; P = .026). The Intubation Difficulty Score of 0 occurred in 30/61 (49.2%) in the McGrath VL group versus 20/63 (31.7%) in the DL group (risk difference 18.9%, 95% CI, 0.6%-37.2%), and a Percentage of Glottic Opening score of 100% was achieved in 37/61 (60.7%) in the McGrath VL group versus 23/63 (36.5%) in the DL group (risk difference 22.1%, 95% CI, 6.2%-37.9%). The overall incidence of intubation-related complications did not differ significantly between groups (McGrath VL: 5/61 [8.2%] vs DL: 7/63 [11.1%], risk difference -4.1%, 95% CI, -14.7%-6.4%); however, esophageal intubation occurred in 0/61 (0%) in the McGrath VL group versus 3/63 (4.8%) in the DL group. CONCLUSION: The McGrath VL significantly improves first-attempt intubation success in infants when used by anesthesia trainees, especially among less experienced providers. Video laryngoscopy may enhance safety and effectiveness in infant airway management. These results support its routine use by novice providers in infant anesthesia.
• Reproducibility of glycocheck measurements in patients under general anesthesia with muscle relaxants: A prospective observational study
  Takayuki Toki, Kazuyuki Mizunoya, Takashi Soejima, Yasunori Yagi, Naoko Nakamine, Yusuke Itosu, Ryo Takagi, Isao Yokota, Yuji Morimoto
  Journal of Clinical Monitoring and Computing, Springer Science and Business Media LLC, 2025年07月10日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）
• Differences of cerebral oxygen saturation in dialysis patients: a comparison of three principals of near infrared spectroscopy.
  Yasunori Yagi, Yasunori Kubo, Koji Hoshino, Kazufumi Okada, Kiyohiko Hotta, Nobuo Shinohara, Yuji Morimoto
  Journal of anesthesia, 37, 6, 861, 867, 2023年12月, ［国内誌］
  英語, 研究論文（学術雑誌）, PURPOSE: It has been reported that cerebral oxygen saturation (rSO2) measured by near infrared spectroscopy is low in dialysis patients. We compared the rSO2 values of dialysis patients before living donor kidney transplantation and their donors as controls by using three spectroscopes that utilize different principals, the INVOS 5100C (spatially resolved spectroscopy), FORE-SIGHT ELITE (modified Beer-Lambert law) and tNIRS-1 (time-resolved spectroscopy). METHODS: Before induction of anesthesia, the sensors of one of the three spectroscopes were placed on the forehead and rSO2 values were recorded followed by the same measurement using the other two spectroscopes. The primary objective was to compare the rSO2 values of the dialysis patients and controls using the three spectroscopes by the unpaired t test. Then we compared the rSO2 values among the spectroscopes in both dialysis patients and controls by one-way ANOVA. Finally, we examined the relations between the rSO2 values and the physiological values by using the Pearson correlation coefficient. RESULTS: Fifteen pairs of dialysis patients and controls were studied. With the INVOS 5100 C, the values of the dialysis patients (59.7 ± 9.7% (mean ± standard deviation) were 13% lower than those of the controls (73.3 ± 6.9%) (P < 0.01). With the tNIRS-1, the values were 57.8 ± 4.8% in the dialysis patients and 63.3 ± 3.5% in the controls (P < 0.01). Almost no differences were observed with the FORE-SIGHT ELITE (71.6 ± 4.9% [dialysis patients] vs. 70.8 ± 4.3% [Controls]) (P = 0.62). Among the spectroscopes, the values were significantly different in both dialysis patients and controls. For the INVOS 5100C and tNIRS-1, correlation coefficients between rSO2 values and blood Hb and serum Alb were more than 0.5. CONCLUSIONS: The rSO2 values for comparisons between the dialysis patients and the controls were different according to differences of the principles of the near infrared spectroscopes. In the INVOS 5100C and tNIRS-1, rSO2 values may be related to blood Hb and serum Alb.
• Intraoperative myocardial infarction and refractory cardiogenic shock during major hepatectomy: a case report
  Yasunori Yagi, Kazuyuki Mizunoya, Toshihiro Mori, Hitoshi Saito, Yuji Morimoto
  JA Clinical Reports, 8, 1, Springer Science and Business Media LLC, 2022年12月, ［筆頭著者］, ［国内誌］
  研究論文（学術雑誌）, Abstract
  
  Background
  
  Myocardial infarction (MI) complicated by cardiogenic shock during non-cardiac surgery is a rare but fatal complication. The management of intraoperative MI is challenging.
  
  Case presentation
  
  A 77-year-old hypertensive man with good functional capacity was scheduled for hepatectomy. After the start of liver resection, the electrocardiogram monitor showed ST depression, and the patient developed refractory cardiogenic shock. Transesophageal echocardiography revealed severe hypokinesis of the anteroseptal wall. The surgery was suspended, and an intra-aortic balloon pump was placed following immediate abdominal closure. Coronary angiography revealed severe stenosis of the left main coronary trunk, and percutaneous coronary intervention (PCI) was performed. Myocardial wall motion improved, and blood pressure stabilized. Two days after PCI, hepatectomy, which had been suspended, was successfully completed.
  
  Conclusions
  
  Once intraoperative MI has occurred, early diagnosis and multidisciplinary approaches are important to manage the difficult clinical situation.
• Altered microvascular reactivity assessed by near-infrared spectroscopy after hepato-pancreato-biliary surgery
  Kazuyuki Mizunoya, Yasunori Yagi, Yuji Morimoto, Satoshi Hirano
  Journal of Clinical Monitoring and Computing, 36, 3, 703, 712, Springer Science and Business Media LLC, 2022年06月, ［国際誌］
  研究論文（学術雑誌）
• Diagnostic timing dependent characteristics of acute kidney injury following hepatectomy: a retrospective historical cohort analysis
  Kazuyuki Mizunoya, Yasunori Yagi, Hirofumi Kamachi, Toshiya Kamiyama, Yuji Morimoto, Akinobu Taketomi
  HPB, 23, 12, 1897, 1905, Elsevier BV, 2021年12月, ［国際誌］
  研究論文（学術雑誌）
• Anesthetic management by blockage of thoracoabdominal nerves through perichondrial approach (TAPA) for open nephrectomy in a pediatric patient with Wilms tumor
  Nobuhiro Tanaka, Yasunori Yagi, Katsuhiro Aikawa, Yuji Morimoto
  Journal of Clinical Anesthesia, 59, 51, 52, Elsevier BV, 2020年02月, ［国際誌］
  研究論文（学術雑誌）
• Changes of Cerebral Oxygenation in Sequential Glenn and Fontan Procedures in the Same Children
  Yasunori Yagi, Masataka Yamamoto, Hitoshi Saito, Toshihiro Mori, Yuji Morimoto, Takayoshi Oyasu, Tsuyoshi Tachibana, Yoichi M. Ito
  Pediatric Cardiology, 38, 6, 1215, 1219, Springer Science and Business Media LLC, 2017年08月, ［国際誌］
  研究論文（学術雑誌）