Morimoto Yuji
| Faculty of Medicine Surgery Anesthesiology and Critical Care Medicine | Specially Appointed Professor |
| Hokkaido University Hospital | Specially Appointed Professor |
Last Updated :2025/06/07
■Researcher basic information
Researchmap personal page
J-Global ID
Educational Organization
- Bachelor's degree program, Departments of Medicine, School of Medicine
- Master's degree program, Graduate School of Medicine
- Doctoral (PhD) degree program, Graduate School of Medicine
■Research activity information
Papers
- Acute decompensated right heart failure potentially triggered by multiple factors including pulmonary vasodilator removal during plasma exchange: a case report.
Takayuki Toki, Kazuyuki Mizunoya, Misa Itabashi, Naoki Nishikawa, Koji Hoshino, Hitoshi Saito, Yuji Morimoto
JA clinical reports, 11, 1, 5, 5, 27 Jan. 2025, [International Magazine]
English, Scientific journal, BACKGROUND: Plasma exchange (PE) removes high-molecular-weight substances and is sometimes used for antineutrophil cytoplasmic antibody-associated vasculitis (AAV) with alveolar hemorrhage. Hypotension during PE is rare, except in allergic cases. We report a case of shock likely caused by increased pulmonary vascular resistance (PVR) during PE. CASE PRESENTATION: A 66-year-old man with pulmonary hypertension (PH) and glomerulonephritis was admitted with dyspnea. He had discontinued sildenafil prior to admission. Alveolar hemorrhage associated with AAV was suspected, and PE was performed. Soon after, he developed circulatory failure and hyperlactatemia. Echocardiography revealed right ventricular dilation, suggesting increased PVR. Inhaled nitric oxide (iNO) was administered, rapidly improving hyperlactatemia and oxygenation. The shock observed during PE was attributed to multiple factors, including the potential removal of sildenafil, which may have led to an increase in PVR. CONCLUSIONS: The shock was attributable to acute right heart failure caused by an exacerbation of PH, possibly due to sildenafil removal via PE, although other contributing factors could not be excluded. - 周術期ランジオロール使用症例における鎮痛効果の検討 ケースシリーズ
黒川 達哉, 相川 勝洋, 打浪 有可, 藤田 憲明, 森本 裕二
臨床麻酔, 49, 1, 51, 54, (株)シービーアール, Jan. 2025
Japanese - 形態異常を伴う椎間関節症に対し3D-CTを参考にインターベンショナル治療を行った1例
伊藤 智樹, 藤井 知昭, 宮田 和磨, 黒川 達哉, 森本 裕二
日本ペインクリニック学会誌, 31, 8, 180, 183, (一社)日本ペインクリニック学会, Aug. 2024
Japanese - McGRATH™ MAC size 1 vs. 2 blades: infant intubation time.
Yuka Uchinami, Noriaki Fujita, Kazuyuki Mizunoya, Isao Yokota, Yuji Morimoto
Journal of anesthesia, 12 Jun. 2024, [Domestic magazines]
English - Cerebral oxygenation saturation in childhood: difference by age and comparison of two cerebral oximetry algorithms.
Yasunori Kubo, Yusuke Itosu, Tomonori Kubo, Hitoshi Saito, Kazufumi Okada, Yoichi M Ito, Yuji Morimoto
Journal of clinical monitoring and computing, 38, 3, 639, 648, Jun. 2024, [International Magazine]
English, Scientific journal, Few reports are available on the monitoring of regional cerebral oxygen saturation (rSO2) in pediatric patients undergoing non-cardiac surgical procedures. In addition, no study has examined the rSO2 levels in children of a broad age range. In this study, we aimed to assess and compare rSO2 levels in pediatric patients of different age groups undergoing non-cardiac surgery. We used two oximeters, tNIRS-1, which uses time-resolved spectroscopy, and conventional INVOS 5100C. Seventy-eight children-26 infants, 26 toddlers, and 26 schoolchildren-undergoing non-cardiac surgery were included. We investigated the differences in the rSO2 levels among the age groups and the correlation between the models and physiological factors influencing the rSO2 values. rSO2 measured by INVOS 5100C was significantly lower in infants than those in other patients. rSO2 measured by tNIRS-1 was higher in the toddler group than those in the other groups. The rSO2 values of tNIRS-1 and INVOS 5100C were moderately correlated (r = 0.41); however, those of INVOS 5100C were approximately 20% higher, and a ceiling effect was observed. The values in INVOS 5100C and tNIRS-1 were affected by blood pressure and the minimum alveolar concentration of sevoflurane, respectively. In pediatric patients undergoing non-cardiac surgery, rSO2 values differed across the three age groups, and the pattern of these differences varied between the two oximeters employing different algorithms. Further research must be conducted to clarify cerebral oxygenation in children. - 上肢の複合性局所疼痛症候群に対し星状神経節レーザーと薬物療法が奏功した1症例
黒川 達哉, 伊藤 智樹, 宮田 和磨, 森本 裕二
日本ペインクリニック学会誌, 31, 2, 56, 56, (一社)日本ペインクリニック学会, Feb. 2024
Japanese - 痛み緩和に難渋し最終的に高用量メサドンで鎮痛が得られたがん性痛の1例
敦賀 健吉, 三浦 基嗣, 黒川 達哉, 伊藤 智樹, 宮田 和磨, 森本 裕二
日本ペインクリニック学会誌, 31, 2, 56, 57, (一社)日本ペインクリニック学会, Feb. 2024
Japanese - Differences of cerebral oxygen saturation in dialysis patients: a comparison of three principals of near infrared spectroscopy.
Yasunori Yagi, Yasunori Kubo, Koji Hoshino, Kazufumi Okada, Kiyohiko Hotta, Nobuo Shinohara, Yuji Morimoto
Journal of anesthesia, 30 Aug. 2023, [Domestic magazines]
English, Scientific journal, PURPOSE: It has been reported that cerebral oxygen saturation (rSO2) measured by near infrared spectroscopy is low in dialysis patients. We compared the rSO2 values of dialysis patients before living donor kidney transplantation and their donors as controls by using three spectroscopes that utilize different principals, the INVOS 5100C (spatially resolved spectroscopy), FORE-SIGHT ELITE (modified Beer-Lambert law) and tNIRS-1 (time-resolved spectroscopy). METHODS: Before induction of anesthesia, the sensors of one of the three spectroscopes were placed on the forehead and rSO2 values were recorded followed by the same measurement using the other two spectroscopes. The primary objective was to compare the rSO2 values of the dialysis patients and controls using the three spectroscopes by the unpaired t test. Then we compared the rSO2 values among the spectroscopes in both dialysis patients and controls by one-way ANOVA. Finally, we examined the relations between the rSO2 values and the physiological values by using the Pearson correlation coefficient. RESULTS: Fifteen pairs of dialysis patients and controls were studied. With the INVOS 5100 C, the values of the dialysis patients (59.7 ± 9.7% (mean ± standard deviation) were 13% lower than those of the controls (73.3 ± 6.9%) (P < 0.01). With the tNIRS-1, the values were 57.8 ± 4.8% in the dialysis patients and 63.3 ± 3.5% in the controls (P < 0.01). Almost no differences were observed with the FORE-SIGHT ELITE (71.6 ± 4.9% [dialysis patients] vs. 70.8 ± 4.3% [Controls]) (P = 0.62). Among the spectroscopes, the values were significantly different in both dialysis patients and controls. For the INVOS 5100C and tNIRS-1, correlation coefficients between rSO2 values and blood Hb and serum Alb were more than 0.5. CONCLUSIONS: The rSO2 values for comparisons between the dialysis patients and the controls were different according to differences of the principles of the near infrared spectroscopes. In the INVOS 5100C and tNIRS-1, rSO2 values may be related to blood Hb and serum Alb. - Acquired laryngomalacia as a cause of post-extubation stridor and extubation failure following craniotomy: a case report.
Kazuyuki Mizunoya, Keisyu Onodera, Yuki Takahashi, Takayuki Toki, Hitoshi Saito, Yuji Morimoto
JA clinical reports, 9, 1, 44, 44, 15 Jul. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: Laryngomalacia is a dynamic airway condition characterized by flaccid laryngeal tissue and inward collapse of supraglottic structures during inspiration. Although it may cause airway obstruction and requires careful management, there have been few reports regarding laryngomalacia after surgery. We report a case of adult-onset laryngomalacia occurred after craniotomy requiring reintubation. CASE PRESENTATION: A 21-year-old man was admitted to the ICU after craniotomy for a cerebellopontine angle tumor. He developed severe stridor immediately after extubation on the postoperative day 2 and required reintubation. On the postoperative day 5, similar episode occurred following re-extubation and fiberoptic laryngoscopy revealed a collapsed epiglottis and left arytenoid into the glottis. A diagnosis of laryngomalacia was made, and he underwent tracheostomy. Laryngomalacia had completely improved; however, bilateral vocal cord paralysis was detected 2 weeks later. CONCLUSIONS: Acquired laryngomalacia should be considered as a possible mechanism of the airway symptoms in a patient with neurological dysfunction. - Factors Affecting Transcranial Motor-Evoked Potential Measurements Using Single-Train Stimulation with an Increased Number of Pulses during Adolescent Scoliosis Surgery: A Prospective Observational Study.
Takayuki Toki, Noriaki Fujita, Tomohiro Ichikawa, Noriki Ochi, Isao Yokota, Hideki Sudo, Yuji Morimoto
Journal of clinical medicine, 12, 13, 30 Jun. 2023, [International Magazine]
English, Scientific journal, Measurement of transcranial motor-evoked potentials (TcMEPs) during scoliosis surgery helps detect postoperative new neurological defects. However, TcMEP interpretation is difficult owing to the influence of intraoperative physiological, pharmacological, and time-related factors as well as stimulation conditions. In this study, we aimed to investigate the effect of the abovementioned factors on TcMEP amplitude using single-train stimulation with an increased number of pulses (STS-INP) during adolescent scoliosis surgery; moreover, we evaluated the complications of TcMEP measurement. We included 50 patients and 706 TcMEP measurements. A total of 1412 TcMEP waveforms were analyzed, each on the bilateral abductor pollicis brevis, tibialis anterior, and abductor hallucis muscles. We estimated the mean difference (95% confidence interval (CI)) and predicted mean difference (95% CI) evaluated using the interquartile range of each factor, based on a mixed-effect model with random intercepts for TcMEP amplitude. The predicted mean differences in TcMEP amplitude were clinically small compared with the actual TcMEP amplitude, suggesting that each factor had a limited effect on TcMEP amplitude. No intraoperative bite injuries or seizures were observed. Using STS-INP during adolescent scoliosis surgery may enable accurate measurement of TcMEP amplitude with neither complications nor the influence of various intraoperative factors. - The comparison of postoperative analgesic requirements between modified thoracoabdominal nerve block through perichondrial approach versus wound infiltration analgesia in patients undergoing gynecological laparoscopic surgery: a retrospective, exploratory study
China Atsumi, Katsuhiro Aikawa, Keita Takahashi, Kazufumi Okada, Yuji Morimoto
JA Clinical Reports, 9, 1, Springer Science and Business Media LLC, 24 Jun. 2023
Scientific journal, Abstract
Introduction
Recently, modified thoracoabdominal nerve block through perichondrial approach (M-TAPA) has been introduced as a novel trunk block. To date, studies comparing its clinical advantages with those of existing local anesthetic techniques are scarce. We aimed to compare the analgesic efficacy of M-TAPA to that of wound infiltration analgesia (WIA) in patients who underwent gynecological laparoscopic surgeries.
Methods
We studied medical records from January 2020 to July 2021 at Hokkaido University Hospital. The primary outcome was the number of analgesic requirements in the first 24 h postoperatively. Secondary outcomes were the time until the first analgesic requirement and adverse events regarding local anesthetic techniques. To address confounding, a regression model was used.
Results
Data from 90 of 231 patients were analyzed (M-TAPA group, n = 40; WIA group, n = 50). For the primary outcome, means and 95% confidence intervals for each group and between-group differences were as follows: 2.25 (1.74, 2.76), 2.28 (1.81, 2.75), and −0.03 (−0.72, 0.66), respectively. Adjusted mean difference was 0.39 (−0.32, 1.11). There were no significant differences in means between groups, with or without adjustment for covariates (p = 0.93, 0.28). Furthermore, no significant difference was detected in the time until the first analgesic requirement and adverse events related to local anesthesia.
Conclusion
Our results demonstrate that M-TAPA did not reduce postoperative analgesic requirements compared to WIA. In a future clinical trial, sufficient visceral pain control may be required to evaluate the effectiveness of M-TAPA over WIA in patients undergoing laparoscopic gynecological surgery. - Chronological changes in plasma levobupivacaine concentrations after bilateral modified thoracoabdominal nerve block through perichondrial approach.
Katsuhiro Aikawa, Yuka Uchinami, Yuji Morimoto
Journal of anesthesia, 06 Jun. 2023, [Domestic magazines]
English, Scientific journal, The local anesthetic (LA) systemic toxicity of trunk blocks is a major concern. Recently, modified thoracoabdominal nerve block through perichondrial approach (M-TAPA) has attracted attention; however, plasma LA level is unknown. We tested whether the peak plasma LA concentration following M-TAPA, using 25 mL of 0.25% levobupivacaine mixed with epinephrine on each side, would be below the toxic level (2.6 μg/mL). We recruited 10 patients undergoing abdominal surgery with planned M-TAPA between November 2021 and February 2022. In all patients, 25 mL of 0.25% levobupivacaine mixed with 1:200,000 epinephrine was administered on each side. Blood samples were obtained at 10, 20, 30, 45, 60, and 120 min after the block. The highest individual peak and the mean peak plasma LA concentrations were 1.03 and 0.73 μg/mL, respectively. We could not capture the peak in five patients; however, the highest concentrations in all patients were significantly lower than the toxic level. A negative correlation between the peak level and body weight was observed. Our results indicated that the plasma LA concentration following M-TAPA using total of 50 mL of 0.25% levobupivacaine with epinephrine remains below the toxic level. Further research is required due to the small sample size of this study.Trial registry number: UMIN000045406. - Effect of cerebrospinal fluid drainage pressure in descending and thoracoabdominal aortic repair: a prospective multicenter observational study.
Kenji Yoshitani, Soshiro Ogata, Shinya Kato, Akito Tsukinaga, Tsunenori Takatani, Nobuhide Kin, Mariko Ezaka, Jun Shimizu, Yuko Furuichi, Shoichi Uezono, Kotaro Kida, Katsuhiro Seo, Shinichi Kakumoto, Hiroshi Miyawaki, Mikito Kawamata, Satoshi Tanaka, Manabu Kakinohana, Shunsuke Izumi, Hiroyuki Uchino, Takayasu Kakinuma, Kimitoshi Nishiwaki, Kazuko Hasegawa, Mishiya Matsumoto, Kazuyoshi Ishida, Atsuo Yamashita, Michiaki Yamakage, Yusuke Yoshikawa, Yuji Morimoto, Hitoshi Saito, Takahisa Goto, Tetsuhito Masubuchi, Masahiko Kawaguchi, Kosuke Tsubaki, Satoshi Mizobuchi, Norihiko Obata, Yoshimi Inagaki, Kazumi Funaki, Yoshiki Ishiguro, Masamitsu Sanui, Kazutaka Taniguchi, Kunihiro Nishimura, Yoshihiko Ohnishi
Journal of anesthesia, 37, 3, 408, 415, Jun. 2023, [Domestic magazines]
English, Scientific journal, PURPOSE: Cerebrospinal fluid drainage (CSFD) is recommended during open or endovascular thoracic aortic repair. However, the incidence of CSFD complications is still high. Recently, CSF pressure has been kept high to avoid complications, but the efficacy of CSFD at higher pressures has not been confirmed. We hypothesize that CSFD at higher pressures is effective for preventing motor deficits. METHODS: This prospective observational study included 14 hospitals that are members of the Japanese Society of Cardiovascular Anesthesiologists. Patients who underwent thoracic and thoracoabdominal aortic repair were divided into four groups: Group 1, CSF pressure around 10 mmHg; Group 2, CSF pressure around 15 mmHg; Group 3, CSFD initiated when motor evoked potential amplitudes decreased; and Group 4, no CSFD. We assessed the association between the CSFD group and motor deficits using mixed-effects logistic regression with a random intercept for the institution. RESULTS: Of 1072 patients in the study, 84 patients (open surgery, 51; thoracic endovascular aortic repair, 33) had motor deficits at discharge. Groups 1 and 2 were not associated with motor deficits (Group 1, odds ratio (OR): 1.53, 95% confidence interval (95% CI): 0.71-3.29, p = 0.276; Group 2, OR: 1.73, 95% CI: 0.62-4.82) when compared with Group 4. Group 3 was significantly more prone to motor deficits than Group 4 (OR: 2.56, 95% CI: 1.27-5.17, p = 0.009). CONCLUSION: CSFD is not associated with motor deficits in thoracic and thoracoabdominal aortic repair with CSF pressure around 10 or 15 mmHg. - 気管切開後に非典型的な出血源による大量喀血を呈した2症例
副島 崇旨, 斉藤 仁志, 森本 裕二
日本集中治療医学会雑誌, 30, Suppl.1, S589, S589, (一社)日本集中治療医学会, Jun. 2023
Japanese - Tilt Tableの傾斜角度変化における呼吸筋機能について
堀 弘明, 佐橋 健人, 斉藤 仁志, 森本 裕二
日本集中治療医学会雑誌, 30, Suppl.1, S826, S826, (一社)日本集中治療医学会, Jun. 2023
Japanese - 大動脈縮窄・離断症に対する大動脈弓形成手術後気道出血発症のリスク因子
泉 岳, 斉藤 仁志, 加藤 裕貴, 水野谷 和之, 糸洲 佑介, 西川 直樹, 武田 充人, 山澤 弘州, 加藤 伸康, 森本 裕二
日本集中治療医学会雑誌, 30, Suppl.1, S648, S648, (一社)日本集中治療医学会, Jun. 2023
Japanese - 大動脈縮窄・離断症に対する大動脈弓形成手術後気道出血発症のリスク因子
泉 岳, 斉藤 仁志, 加藤 裕貴, 水野谷 和之, 糸洲 佑介, 西川 直樹, 武田 充人, 山澤 弘州, 加藤 伸康, 森本 裕二
日本集中治療医学会雑誌, 30, Suppl.1, S648, S648, (一社)日本集中治療医学会, Jun. 2023
Japanese - Effects of ephedrine and phenylephrine on cerebral oxygenation: observational prospective study using near-infrared time-resolved spectroscopy.
Yasunori Kubo, Tomonori Kubo, Takayuki Toki, Isao Yokota, Yuji Morimoto
Journal of clinical monitoring and computing, 27 May 2023, [International Magazine]
English, Scientific journal, It has been reported that cerebral oxygenation (ScO2) measured by near infrared spectroscopy is maintained or increased by treatment with ephedrine, whereas almost all previous reports demonstrated that phenylephrine reduced ScO2. As the mechanism of the latter, the interference of the extracranial blood flow, that is extracranial contamination, has been suspected. Accordingly, in this prospective observational study, we utilized time-resolved spectroscopy (TRS), in which the effect of extracranial contamination is thought to be minimal, and evaluated whether the same result was obtained. We measured the changes in ScO2 as well as the total cerebral hemoglobin concentration (tHb) after treatment with ephedrine or phenylephrine during laparoscopic surgery by using a tNIRS-1 (Hamamatsu Photonics, Hamamatsu, Japan), which is a commercial instrument utilizing TRS. Based on a mixed-effects model with random intercepts for ScO2 or tHb including mean blood pressure, the mean difference and 95% confidence interval were evaluated as well as the predicted mean difference and its confidence interval using the interquartile range of mean blood pressure. Fifty treatments with ephedrine or phenylephrine were done. The mean differences of ScO2 were less than 0.1% and the predicted mean differences were less than 1.1% for the two drugs. The mean differences of tHb were less than 0.02 μM and the predicted mean differences were less than 0.2 μM for the drugs. The changes in ScO2 and tHb after treatments with ephedrine and phenylephrine were very small and clinically insignificant when measured by TRS. Previous reports about phenylephrine may have been affected by extracranial contamination. - 肝胆膵手術後患者における過大腎クリアランス発生に関する検討 症例対照研究
中峯 奈央子, 水野谷 和之, 佐々木 慶子, 出村 理海, 斉藤 仁志, 森本 裕二
日本集中治療医学会雑誌, 30, 3, 171, 177, (一社)日本集中治療医学会, May 2023
Japanese - 肝胆膵手術後患者における過大腎クリアランス発生に関する検討 症例対照研究
中峯 奈央子, 水野谷 和之, 佐々木 慶子, 出村 理海, 斉藤 仁志, 森本 裕二
日本集中治療医学会雑誌, 30, 3, 171, 177, (一社)日本集中治療医学会, May 2023
Japanese - Change in cerebral circulation during the induction of anesthesia with remimazolam.
Takashi Soejima, Kentaro Ueda, Sakae Hasegawa, Hiromitsu Motoe, Kazufumi Okada, Yoichi M Ito, Koji Hoshino, Yuji Morimoto
Journal of anesthesia, 37, 1, 92, 96, Feb. 2023, [Domestic magazines]
English, Scientific journal, PURPOSE: Remimazolam is a new ultra-short-acting benzodiazepine with unknown effects on cerebral circulation. We measured total cerebral hemoglobin concentrations, which reflect cerebral blood volume (CBV), and cerebral oxygen saturation, using time-domain near-infrared spectroscopy, which can measure the absolute values of cerebral hemoglobin concentrations. We also measured cerebral blood flow velocity (CBFV) in the middle cerebral artery using transcranial Doppler as an indicator of cerebral blood flow (CBF). We did so to examine the effect of remimazolam on cerebral circulation in humans, as assessed CBV, CBF, and cerebral oxygen saturation. METHODS: This was a prospective, observational study. Fifteen patients without serious complications scheduled for general anesthesia were recruited. We measured total cerebral hemoglobin concentrations, CBFV, and cerebral oxygen saturation throughout the anesthetic induction course with remimazolam. RESULTS: Total cerebral hemoglobin concentrations did not change during the process (p = 0.51). In contrast, the mean CBFV was reduced by 11% (significant, p = 0.04). The drop in mean blood pressure following the induction of anesthesia was 17%; however, it was within the range of cerebrovascular autoregulation. Moreover, cerebral oxygen saturation increased by 4% (statistically significant, p < 0.01). CONCLUSIONS: We found that anesthetic induction with remimazolam did not alter CBV and reduced CBF in uncomplicated patients. - Tilt Tableの傾斜角度変化における肺活量測定時の腹部筋厚について
堀 弘明, 千葉 健, 佐橋 健人, 斉藤 仁志, 森本 裕二
日本集中治療医学会雑誌, 29, Suppl.1, 415, 415, (一社)日本集中治療医学会, Nov. 2022
Japanese - 敗血症性脳症治療の最前線 敗血症が海馬シナプス可塑性へ与える影響と治療可能性
干野 晃嗣, 副島 崇旨, 打浪 有可, 森本 裕二
日本集中治療医学会雑誌, 29, Suppl.1, 280, 280, (一社)日本集中治療医学会, Nov. 2022
Japanese - 神経発達を見据えた麻酔 神経発達と麻酔薬の選択
斉藤 仁志, 内田 洋介, 森本 裕二
日本小児麻酔学会誌, 27, Suppl., 62, 62, (一社)日本小児麻酔学会, Oct. 2022
Japanese - 麻酔導入後に高度低血圧を呈した回腸導管造設後患者の一例
出村 理海, 斉藤 仁志, 本江 勲充, 森本 裕二
日本臨床麻酔学会誌, 42, 6, S252, S252, 日本臨床麻酔学会, Oct. 2022
Japanese - The relationship between years of anesthesia experience and first-time intubation success rate with direct laryngoscope and video laryngoscope in infants: a retrospective observational study.
Yuka Uchinami, Noriaki Fujita, Takashi Ando, Kazuyuki Mizunoya, Koji Hoshino, Isao Yokota, Yuji Morimoto
Journal of anesthesia, 20 Sep. 2022, [Domestic magazines]
English, Scientific journal, PURPOSE: Studies in adults have reported that video laryngoscope is more useful than direct laryngoscope when training less experienced anesthesiologists. However, whether this is true for infants remains unclear. Therefore, this study aimed to evaluate whether the use of video laryngoscope would result in smaller differences in success rate according to anesthesiologists' expertise than those in direct laryngoscope. METHODS: Medical records and video recordings from the operating room of patients aged < 1 year who underwent non-cardiac surgery between March 2019 and September 2021 were reviewed. Tracheal intubations between April 8, 2020, and June 20, 2021, were excluded due to the shortage of video laryngoscope blades during the COVID-19 pandemic. Rates of first-time tracheal intubation success were compared by years of anesthesia experience and initial intubation device. RESULTS: In total, 125 of 175 tracheal intubations were analyzed (direct laryngoscope group, n = 72; video laryngoscope group, n = 53). The first-time tracheal intubation success rate increased with years of experience as an anesthesiologist in the direct laryngoscope group (odds ratio OR 1.70, 95% confidence interval CI 1.15, 2.49; P = 0.0070), but not the video laryngoscope group (OR 0.99, 95% CI 0.74, 1.35; P = 0.99). CONCLUSION: The differences in success rate according to the anesthesiologists' years of experience were non-significant when using video laryngoscope in infants, compared to those in direct laryngoscope. - Changes in Cerebral Hemodynamics During Systemic Pulmonary Shunt and Pulmonary Artery Banding in Infants with Congenital Heart Disease.
Yoshifumi Takeda, Masataka Yamamoto, Koji Hoshino, Yoichi M Ito, Nobuyasu Kato, Satoru Wakasa, Yuji Morimoto
Pediatric cardiology, 01 Sep. 2022, [International Magazine]
English, Scientific journal, Palliative surgery is often performed in the treatment of congenital heart disease. Two representative palliative procedures are the systemic pulmonary shunt and pulmonary artery banding. Dramatic changes in cerebral hemodynamics may occur in these operations due to changes in the pulmonary-to-systemic blood flow ratio and systemic oxygenation. However, there seem to be almost no studies evaluating them. Accordingly, we evaluated cerebral perfusion by transcranial Doppler ultrasonography and cerebral oxygenation by near infrared spectroscopy during these procedures. In the post hoc analysis of a previous prospective observational study, cerebral blood flow velocities of the middle cerebral artery measured by transcranial Doppler were compared between the start and end of surgery as were the pulsatility index and resistance index. The cerebral oxygenation values were also compared between the start and end of surgery. Twenty-two infants with systemic pulmonary shunt and 20 infants with pulmonary artery banding were evaluated. There were no significant differences of the flow velocities between the start and end of surgery in either procedure. The pulsatility index significantly increased after pulmonary artery banding, which may compete with the increase in cerebral perfusion due to the increase in systemic blood flow. The cerebral oxygenation decreased in both procedures, possibly due to an increase in body temperature. Arterial oxygen saturation was almost the same before and after both procedures. Contrary to our expectation, the changes in cerebral hemodynamics in the palliative operations were small if the management of physiological indices such as arterial oxygen saturation was properly performed during the procedures. - Age Difference of the Relationship Between Cerebral Oxygen Saturation and Physiological Parameters in Pediatric Cardiac Surgery with Cardiopulmonary Bypass: Analysis Using the Random-Effects Model.
Masataka Yamamoto, Takayuki Toki, Yasunori Kubo, Koji Hoshino, Yuji Morimoto
Pediatric cardiology, 43, 7, 1606, 1614, 03 Jun. 2022, [International Magazine]
English, Scientific journal, Recently, monitoring of cerebral oxygen saturation (ScO2) has become widespread in pediatric cardiac surgery. Our previous study reported that mean blood pressure (mBP) was the major contributor to ScO2 throughout cardiac surgery with cardiopulmonary bypass (CPB) in children weighing under 10 kg. We speculated that this result might be attributable to incomplete cerebral autoregulation in such young children. Accordingly, our hypothesis is that the relationship between ScO2 and the physiological parameters may change according to the growth of the children. ScO2 was measured with an INVOS 5100C (Somanetics, Troy, MI). Random-effects analysis was employed with ScO2 as a dependent variable, and seven physiological parameters (mBP, central venous pressure, nasopharyngeal temperature, SaO2, hematocrit, PaCO2, and pH) were entered as independent covariates. The analysis was performed during the pre-CPB, CPB, and post-CPB periods by dividing the patients into two groups: infants (Infant Group) and children who were more than 1 year old (Child Group). The Infant and Child Groups consisted of 28 and 21 patients. In the random-effects analysis, mBP was the major contributor to ScO2 during CPB in both groups. During the pre-CPB period, the effect of mBP was strongest in the Infant group. However, its effect was second to that of SaO2 in the Child Group. During the post-CPB period, SaO2 and mBP still affected ScO2 in the Infant group. However, the dominant contributors were unclear in the Child Group. Cerebral autoregulation may be immature in infants. In addition, it may be impaired during CPB even after 1 year of age. - 【発達期の脳に対する麻酔・鎮静薬の影響:いまとこれから】基礎研究の立場から 自験例を含めた文献報告を踏まえ現在わかっていること
内田 洋介, 斉藤 仁志, 森本 裕二
LiSA, 29, 5, 470, 474, (株)メディカル・サイエンス・インターナショナル, May 2022
Japanese - Intraoperative myocardial infarction and refractory cardiogenic shock during major hepatectomy: a case report.
Yasunori Yagi, Kazuyuki Mizunoya, Toshihiro Mori, Hitoshi Saito, Yuji Morimoto
JA clinical reports, 8, 1, 19, 19, 09 Mar. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: Myocardial infarction (MI) complicated by cardiogenic shock during non-cardiac surgery is a rare but fatal complication. The management of intraoperative MI is challenging. CASE PRESENTATION: A 77-year-old hypertensive man with good functional capacity was scheduled for hepatectomy. After the start of liver resection, the electrocardiogram monitor showed ST depression, and the patient developed refractory cardiogenic shock. Transesophageal echocardiography revealed severe hypokinesis of the anteroseptal wall. The surgery was suspended, and an intra-aortic balloon pump was placed following immediate abdominal closure. Coronary angiography revealed severe stenosis of the left main coronary trunk, and percutaneous coronary intervention (PCI) was performed. Myocardial wall motion improved, and blood pressure stabilized. Two days after PCI, hepatectomy, which had been suspended, was successfully completed. CONCLUSIONS: Once intraoperative MI has occurred, early diagnosis and multidisciplinary approaches are important to manage the difficult clinical situation. - Neonatal isoflurane exposure disturbs granule cell migration in the rat dentate gyrus
Yosuke UCHIDA, Toshikazu HASHIMOTO, Hitoshi SAITO, Koichi TAKITA, Yuji MORIMOTO
Biomedical Research, 43, 1, 1, 9, Biomedical Research Press, 17 Feb. 2022
Scientific journal - Clinical features and significance of leukopenia occurring immediately after endovascular surgery.
Takashi Soejima, Kazuyuki Mizunoya, Yuki Izumi, Takeshi Yokoyama, Ryo Takagi, Yuji Morimoto
Journal of anesthesia, 36, 1, 144, 151, Feb. 2022, [Domestic magazines]
English, Scientific journal, PURPOSE: Inflammation after stent graft surgery is known as postimplantation syndrome (PIS) and it causes leukocytosis. However, we have experienced leukopenia in the very early postoperative phase of endovascular surgery at our institution. We investigated leukopenia, an under-recognized phenomenon that occurred after transcatheter aortic valve implantation (TAVI), endovascular aortic repair (EVAR), and thoracic endovascular aortic repair (TEVAR). METHODS: Records of patients who underwent TAVI, EVAR, and TEVAR between March 2018 and February 2019 were retrospectively reviewed. Primary outcomes were the decline rate of white blood cell count (DR-WBC) in the immediate postoperative period and its differences among surgical procedures. The secondary endpoint was the relationship between DR-WBC and infectious complications. Furthermore, the incidence of PIS and its differences among the procedures and associations with DR-WBC were evaluated. RESULTS: A total of 108 patients (TAVI 41, EVAR 37, TEVAR 30) were included. DR-WBC immediately after surgery was higher in the TAVI group when compared with other groups (TAVI, 43.1 ± 22.6%; EVAR, 27.6 ± 17.3%; TEVAR, 25.4 ± 27.4%; P < 0.01). DR-WBC was not significantly different regardless of postoperative infection (P = 0.45) or PIS (P = 0.62). The incidence rate of PIS was higher in the EVAR group compared with the TAVI group, and was not associated with DR-WBC. CONCLUSIONS: Leukopenia was a common phenomenon immediately after endovascular surgery, especially TAVI. It resolved a day after surgery and was not associated with PIS or infectious complications. Therefore, it seems to be a transient abnormal hematological finding and a self-limiting condition. - 急性A型大動脈解離の緊急手術を施行したBm血液型亜型の1症例
小野寺 慧洲, 原澤 克巳, 枝窪 俊輔, 水野谷 和之, 森本 裕二
麻酔, 70, 12, 1332, 1335, 克誠堂出版(株), Dec. 2021
Japanese - Evaluation of sensory loss obtained by modified-thoracoabdominal nerves block through perichondrial approach in patients undergoing gynecological laparoscopic surgery: a prospective observational study.
Katsuhiro Aikawa, Isao Yokota, Yosuke Maeda, Yuji Morimoto
Regional anesthesia and pain medicine, 47, 2, 134, 135, 20 Jul. 2021, [International Magazine]
English, Scientific journal - 非心臓手術の術中管理における最近の脳循環の話題
森本 裕二, 糸洲 佑介, 久保 康則, 相川 勝洋
臨床麻酔, 45, 7, 949, 956, 真興交易(株)医書出版部, Jul. 2021
Japanese - Changes of cerebral oxygenation indices measured by near infrared time-resolved spectroscopy during spinal anesthesia for cesarean section: Simultaneous measurement with cerebral blood flow.
Yusuke Itosu, Yasunori Kubo, Mamoru Morikawa, Hidemichi Watari, Yuji Morimoto
The journal of obstetrics and gynaecology research, 47, 7, 2371, 2379, Jul. 2021, [International Magazine]
English, Scientific journal, AIM: To measure the changes in cerebral oxygenation indices by near infrared time-resolved spectroscopy and the cerebral blood flow simultaneously after spinal anesthesia for cesarean section. METHODS: This prospective observational study was conducted for 25 pregnant women scheduled for elective cesarean section under spinal anesthesia. During a period of 15 min after spinal anesthesia, cerebral oxygenation (ScO2 ), and the total cerebral hemoglobin concentration (tHb) were measured using near infrared time-resolved spectroscopy and mean cerebral blood flow velocity (Vm) was measured using transcranial Doppler ultrasonography. Next, in the women who had nausea during the observed period, we compared these values when nausea was detected with those when it was not. RESULTS: Mean arterial pressure (MAP) decreased to around 60 mmHg (by 25% compared to the control) 6 min after spinal anesthesia. Compared to the control, ScO2 decreased by about 3% after 6 min and then gradually increased. The tHb, which reflects cerebral blood volume started to decrease just after spinal anesthesia and this continued until 12 min (the decrease was about 12%). Vm decreased by about 7%. In the 14 women who had nausea, MAP, Vm, and ScO2 values when nausea was detected were significantly lower than when it was not. CONCLUSION: The changes in cerebral hemodynamics may be small after spinal anesthesia in ordinary cesarean section compared to the reduction of systemic arterial blood pressure. There might be greater decreases in cerebral blood flow and oxygenation when nausea occurred in the pregnant women who experienced it after spinal anesthesia. - Effects of The Prone Position on Regional Neutrophilic Lung Inflammation According To 18F-FDG PET In An Experimental Ventilator-Induced Lung Injury Model.
Susumu Nakahashi, Hiroshi Imai, Nobutake Shimojo, Yasuhiro Magata, Takahiro Einama, Mineji Hayakawa, Takeshi Wada, Yuji Morimoto, Satoshi Gando
Shock (Augusta, Ga.), 57, 2, 298, 308, 08 Jun. 2021, [International Magazine]
English, Scientific journal, ABSTRACT: Ventilator-induced lung injury (VILI) can be life-threatening and it is important to prevent the development of VILI. It remains unclear whether the prone position affects neutrophilic inflammation in the lung regions in vivo, which plays a crucial role in the pathogenesis of VILI. This study aimed to assess the relationship between the use of the prone position and the development of VILI-associated regional neutrophilic lung inflammation. Regional neutrophilic lung inflammation and lung aeration during low tidal volume mechanical ventilation were assessed using in vivo 2-deoxy-2-[ (18)F] fluoro-D-glucose (18F-FDG) positron emission tomography and computed tomography in acutely experimentally injured rabbit lungs (lung injury induced by lung lavage and excessive ventilation). Direct comparisons were made among three groups: control, supine, and prone position. After approximately 7 hours, tissue-normalized 18F-FDG uptake differed significantly between the supine and prone positions (SUP: 0.038 ± 0.014 vs. PP: 0.029 ± 0.008, P = 0.038), especially in the ventral region (SUP: 0.052 ± 0.013 vs. PP: 0.026 ± 0.007, P = 0.003). The use of the prone position reduced lung inhomogeneities, which was demonstrated by the correction of the disproportionate rate of voxel gas over the given lung region. The progression of neutrophilic inflammation was affected by the interaction between the total strain (for aeration) and the inhomogeneity. The prone position is effective in slowing down the progression of VILI-associated neutrophilic inflammation. Under low-tidal-volume ventilation, the main drivers of the its effect may be homogenization of lung tissue and that of mechanical forces. - Diagnostic timing dependent characteristics of acute kidney injury following hepatectomy: a retrospective historical cohort analysis.
Kazuyuki Mizunoya, Yasunori Yagi, Hirofumi Kamachi, Toshiya Kamiyama, Yuji Morimoto, Akinobu Taketomi
HPB : the official journal of the International Hepato Pancreato Biliary Association, 18 May 2021, [International Magazine]
English, Scientific journal, BACKGROUND: The timing of diagnosis of post-hepatectomy acute kidney injury (AKI) has rarely been investigated. The aim of this retrospective study was to reveal the differences between AKI subtypes following hepatectomy, as classified by timing of diagnosis. METHOD: Post-hepatectomy AKI was classified as very transient AKI (vtAKI; criteria satisfied by the serum creatinine value immediately after surgery) or non-transient AKI (ntAKI; all other AKI types except for vtAKI). Multivariate logistic regression analyses for both AKI types were performed separately to identify differences in known perioperative AKI risk factors. The impacts of each AKI subtype on postoperative complications, hospital stay and renal outcome at discharge were also evaluated. RESULTS: AKI was diagnosed in 135 of 750 patients (18.0%); 82 and 53 patients were classified as vtAKI and ntAKI, respectively. In multivariate analysis, even among the perioperative factors associated with whole AKI, there were distinct relationships depending on vtAKI or ntAKI. Furthermore, only ntAKI was associated with postoperative complications, longer hospital stays and impaired renal function at discharge. CONCLUSIONS: Based on the results of this study, future post-hepatectomy AKI studies should only include ntAKI and exclude vtAKI, as vtAKI has minimal clinical impact despite accounting for a significant proportion of AKI patients. CLINICAL TRIAL REGISTRATIONS: None. - 心房性ナトリウム利尿ペプチドの持つ第3の作用 血管透過性とグリコカリックスに与える影響
水野谷 和之, 森本 裕二
日本集中治療医学会雑誌, 28, 3, 173, 179, (一社)日本集中治療医学会, May 2021
Japanese - Altered microvascular reactivity assessed by near-infrared spectroscopy after hepato-pancreato-biliary surgery.
Kazuyuki Mizunoya, Yasunori Yagi, Yuji Morimoto, Satoshi Hirano
Journal of clinical monitoring and computing, 36, 3, 703, 712, 07 Apr. 2021, [International Magazine]
English, Scientific journal, Little is known about microcirculatory dysfunction following abdominal surgeries. This study aimed to evaluate changes in microvascular reactivity (MVR) before and after major abdominal surgery, assessed by near-infrared spectroscopy in conjunction with a vascular occlusion test. This prospective observational study included 50 adult patients who underwent hepato-pancreato-biliary surgery lasting ≥ 8 h. MVR was assessed by tissue oxygen saturation (StO2) changes in the plantar region of the foot during 3 min of vascular occlusion and subsequent release under general anesthesia before and after surgery. The primary outcome was alteration in the recovery slope of StO2 (RecStO2) and recovery time (tM) between the preoperative and postoperative values. Postoperative short-term outcome was represented by the Post-operative Morbidity Survey (POMS) score on the morning of postoperative day 2. After surgery, RecStO2 was reduced (0.74% [0.58-1.06]/s vs. 0.89% [0.62-1.41]/s, P = 0.001), and tM was longer (57.0 [42.9-71.0] s vs. 41.3 [35.5-56.5] s, P < 0.001), compared to the preoperative values. Macrohemodynamic variables such as cardiac index, arterial pressure, and stroke volume during postoperative measurement did not differ with or without relative MVR decline. In addition, the POMS score was not associated with postoperative alterations in microcirculatory responsiveness. MVR in the plantar region of the foot was reduced after major hepato-pancreato-biliary surgery regardless of macrocirculatory adequacy. Impaired MVR was not associated with short-term outcomes as long as macrocirculatory indices were well maintained. The impact of relative microcirculatory changes, especially combined with inadequate macrocirculation, on postoperative complications remains to be elucidated.Clinical Trial Registrations UMIN-CTR trial ID: 000033461. - ビーチチェア体位での関節鏡下肩手術における脳酸素飽和度の変化 空間分解分光法を用いた前向き観察研究
糸洲 佑介, 原田 聡子, 田中 暢洋, 加藤 亮子, 森本 裕二
麻酔, 70, 4, 367, 373, 克誠堂出版(株), Apr. 2021
Japanese - 特発性腹腔内出血により出血性ショックに至った患者の超緊急帝王切開の麻酔経験
安藤 貴士, 水野谷 和之, 雨森 英彦, 斉藤 仁志, 森本 裕二
麻酔, 70, 4, 413, 416, 克誠堂出版(株), Apr. 2021
Japanese - Interleukin-1β Modulates Synaptic Transmission and Synaptic Plasticity During the Acute Phase of Sepsis in the Senescence-Accelerated Mouse Hippocampus.
Koji Hoshino, Yuka Uchinami, Yosuke Uchida, Hitoshi Saito, Yuji Morimoto
Frontiers in aging neuroscience, 13, 637703, 637703, 2021, [International Magazine]
English, Scientific journal, Background: Aging and pre-existing cognitive impairment are considered to be independent risk factors for sepsis-associated encephalopathy. This study aimed to investigate the manner in which aging and pre-existing cognitive dysfunction modified neuroinflammation, synaptic plasticity, and basal synaptic transmission during the acute phase of sepsis using Senescence-Accelerated Mice Prone 8 (SAMP8) and Senescence-Accelerated Resistant Mice 1 (SAMR1). Methods: We used 6-month-old SAMP8 and SAMR1. Sepsis was induced using cecal ligation and puncture (CLP). The animal's hippocampi and blood were collected for subsequent investigations 24 h after surgery. Results: Long-term potentiation (LTP) was impaired in the Shaffer-collateral (SC)-CA1 pathway of the hippocampus in SAMP8 without surgery compared to the age-matched SAMR1, which was reflective of cognitive dysfunction in SAMP8. CLP impaired the SC-CA1 LTP in SAMR1 compared to the sham-operated controls, but not in SAMP8. Moreover, CLP decreased the input-output curve and increased the paired-pulse ratio in SAMP8, suggesting the reduced probability of basal synaptic transmission due to sepsis. Immunohistochemical analysis revealed that CLP elevated IL-1β levels, especially in the hippocampi of SAMP8 with microglial activation. In vivo peripheral IL-1 receptor antagonist (IL-1ra) administration in the septic SAMP8 revealed that the neuroinflammation was not correlated with the peripheral elevation of IL-1β. Ex vivo IL-1ra administration to the hippocampus ameliorated LTP impairment in SAMR1 and the reduction in basal transmission in SAMP8 after sepsis. Conclusions: The mechanism of the modulation of synaptic transmission and synaptic plasticity by the acute stage of sepsis differed between SAMR1 and SAMP8. These changes were related to centrally derived IL-1 receptor-mediated signaling and were accompanied by microglial activation, especially in SAMP8. - An effective case of shichimotsukokato treatment for postherpetic neuralgia in a patient with chronic kidney disease
Tomoaki Fujii, Yuji Morimoto
Traditional & Kampo Medicine, 7, 3, 180, 182, Wiley, Dec. 2020
Scientific journal - The Relationships of Cerebral and Somatic Oxygen Saturation with Physiological Parameters in Pediatric Cardiac Surgery with Cardiopulmonary Bypass: Analysis Using the Random-Effects Model.
Masataka Yamamoto, Toshihiro Mori, Takayuki Toki, Yusuke Itosu, Yasunori Kubo, Isao Yokota, Yuji Morimoto
Pediatric cardiology, 42, 2, 370, 378, 17 Nov. 2020, [International Magazine]
English, Scientific journal, Recently, tissue oxygenation in pediatric heart surgery is measured by using near-infrared spectroscopy. Monitoring of cerebral oxygen saturation (ScO2) is most common but that of somatic tissue oxygen saturation (SrO2) is also gradually becoming widespread. However, the value of their monitoring is not well established. One of the reasons for this may be that the physiological factors affecting ScO2 and SrO2 have not been sufficiently clarified. Accordingly, we prospectively observed the changes in ScO2 and SrO2 simultaneously throughout cardiac surgery with cardiopulmonary bypass (CPB) in children weighing under 10 kg and evaluated their relationships with physiological parameters by using the random-effects model. ScO2 and SrO2 were measured with an INVOS 5100C (Somanetics, Troy, MI, USA). The random-effects analysis was applied for ScO2 and SrO2, as dependent variables, and seven physiological parameters (mean blood pressure, central venous pressure, rectal temperature, SaO2, hematocrit PaCO2, and pH) were entered as independent covariates. The analysis was performed during the pre-CPB, CPB, and post-CPB periods. Next, the same analysis was performed by dividing the patients into univentricular and biventricular physiological types. Forty-one children were evaluated. Through the whole surgical period, ScO2 correlated strongly with mean blood pressure regardless of the physiological type. On the other hand, the contribution of mean blood pressure to SrO2 was weak and various other parameters were related to SrO2 changes. Thus, the physiological parameters affecting ScO2 and SrO2 were rather different. Accordingly, the significance of monitoring of cerebral and somatic tissue oxygen saturation in pediatric cardiac surgery should be further evaluated. - ECMO補助下の呼吸不全患者の航空搬送経験
糸洲 佑介, 斉藤 仁志, 打浪 有可, 本間 慶憲, 吉田 知由, 干野 晃嗣, 西川 直樹, 森本 裕二
日本集中治療医学会雑誌, 27, 6, 491, 492, (一社)日本集中治療医学会, Nov. 2020
Japanese - Subanesthetic ketamine exerts antidepressant-like effects in adult rats exposed to juvenile stress.
Katsuhiro Aikawa, Takayuki Yoshida, Yu Ohmura, Kerise Lyttle, Mitsuhiro Yoshioka, Yuji Morimoto
Brain research, 1746, 146980, 146980, 01 Nov. 2020, [International Magazine]
English, Scientific journal, Juvenile stress, like that caused by childhood maltreatment, is a significant risk factor for psychiatric disorders such as depression later in life. Recently, the antidepressant effect of ketamine, a noncompetitive N-methyl-d-aspartate receptor antagonist, has been widely investigated. However, little is known regarding its efficacy against depressive-like alterations caused by juvenile stress, which is clinically relevant in human depression. In the present study, we evaluated the antidepressant-like effect of ketamine in adult rats that had been subjected to juvenile stress. Depressive-like behavior was assessed using the forced swim test (FST), and electrophysiological and morphological alterations in the layer V pyramidal cells of the prelimbic cortex were examined using whole-cell patch-clamp recordings and subsequent recording-cell specific fluorescence imaging. We demonstrated that ketamine (10 mg/kg) attenuated the increased immobility time caused by juvenile stress in the FST, restored the diminished excitatory postsynaptic currents, and caused atrophic changes in the apical dendritic spines. Ketamine's effects reversing impaired excitatory/inhibitory ratio of postsynaptic currents were also revealed. These results indicated that ketamine could be effective in reversing the depression-like alterations caused by juvenile stress. - Bm血液型亜型で急性A型大動脈解離の緊急手術を必要とした1症例
小野寺 慧洲, 枝窪 俊輔, 森本 裕二
日本臨床麻酔学会誌, 40, 6, S269, S269, 日本臨床麻酔学会, Oct. 2020
Japanese - 血清抗O157LPS抗体を用いて腸管出血性大腸菌感染症と診断した小児溶血性尿毒症症候群の1例
土岐 崇幸, 斉藤 仁志, 久保 康則, 秋田 敬介, 佐々木 慶子, 森本 裕二
日本臨床麻酔学会誌, 40, 5, 485, 489, 日本臨床麻酔学会, Sep. 2020
Japanese - 診療報酬改定による多人数用高気圧酸素治療の現状
武貞 敬介, 石川 勝清, 平子 竜大, 岡本 花織, 岩崎 毅, 佐々木 亮, 法邑 まなみ, 松本 剛直, 千葉 裕基, 村田 裕宣, 植村 勇人, 室谷 黎奈, 寒河江 磨, 太田 稔, 森本 裕二
公益社団法人北海道臨床工学技士会会誌, 30, 150, 152, (公社)北海道臨床工学技士会, Sep. 2020
Japanese - 術前心血管合併症低リスク患者において肝切除術中に心筋梗塞をきたした一例
八木 泰憲, 水野谷 和之, 森 敏洋, 斉藤 仁志, 森本 裕二
Cardiovascular Anesthesia, 24, Suppl., 140, 140, (一社)日本心臓血管麻酔学会, Sep. 2020
Japanese - 血清抗O157LPS抗体を用いて腸管出血性大腸菌感染症と診断した小児溶血性尿毒症症候群の1例
土岐 崇幸, 斉藤 仁志, 久保 康則, 秋田 敬介, 佐々木 慶子, 森本 裕二
日本臨床麻酔学会誌, 40, 5, 485, 489, 日本臨床麻酔学会, Sep. 2020
Japanese - Cantrell症候群に合併した大動脈縮窄複合に対するNorwood手術の一例
坂井 俊朗, 斉藤 仁志, 水野谷 和之, 田中 暢洋, 森本 裕二
Cardiovascular Anesthesia, 24, 1, 127, 130, (一社)日本心臓血管麻酔学会, Aug. 2020
Japanese - Cantrell症候群に合併した大動脈縮窄複合に対するNorwood手術の一例
坂井 俊朗, 斉藤 仁志, 水野谷 和之, 田中 暢洋, 森本 裕二
Cardiovascular Anesthesia, 24, 1, 127, 130, (一社)日本心臓血管麻酔学会, Aug. 2020
Japanese - ビデオ喉頭鏡McGRATH MACを用いて気管チューブ交換を行った際に、外科的止血を要する右扁桃損傷を生じた1症例
前田 洋典, 西田 紳悟, 水野谷 和之, 森 敏洋, 斉藤 仁志, 森本 裕二
臨床麻酔, 44, 6, 869, 871, 真興交易(株)医書出版部, Jun. 2020
Japanese - 全身麻酔導入時の脳循環変化 時間分解近赤外分光法と経頭蓋ドプラを用いた前向き観察研究
副島 崇旨, 内田 洋介, 斉藤 仁志, 森本 裕二
麻酔, 69, 5, 530, 537, 克誠堂出版(株), May 2020
Japanese - 術前に甲状腺機能低下状態が確認された場合の手術延期の是非について
森本 裕二, 相川 勝洋, 三好 寛二, 堤 保夫
臨床麻酔, 44, 5, 715, 718, 真興交易(株)医書出版部, May 2020
Japanese - 【ICU治療指針 III】手術・麻酔と周術期管理 成人肝移植術の周術期管理(術後管理を中心に)
斉藤 仁志, 加藤 裕貴, 森本 裕二
救急・集中治療, 31, 4, 1523, 1528, (株)総合医学社, Mar. 2020
Japanese - 【ICU治療指針 III】手術・麻酔と周術期管理 小児肝移植の周術期管理
斉藤 仁志, 干野 晃嗣, 森本 裕二
救急・集中治療, 31, 4, 1529, 1532, (株)総合医学社, Mar. 2020
Japanese - 【ICU治療指針 III】手術・麻酔と周術期管理 周術期の血液製剤の用い方
斉藤 仁志, 水野谷 和之, 森本 裕二
救急・集中治療, 31, 4, 1584, 1589, (株)総合医学社, Mar. 2020
Japanese - 【ICU治療指針 III】手術・麻酔と周術期管理 周術期の血液製剤の用い方
斉藤 仁志, 水野谷 和之, 森本 裕二
救急・集中治療, 31, 4, 1584, 1589, (株)総合医学社, Mar. 2020, [Peer-reviewed]
Japanese - 【ICU治療指針 III】手術・麻酔と周術期管理 小児肝移植の周術期管理
斉藤 仁志, 干野 晃嗣, 森本 裕二
救急・集中治療, 31, 4, 1529, 1532, (株)総合医学社, Mar. 2020, [Peer-reviewed]
Japanese - Modified thoracoabdominal nerves block through perichondrial approach (M-TAPA) provides a sufficient postoperative analgesia for laparoscopic sleeve gastrectomy.
Katsuhiro Aikawa, Nobuhiro Tanaka, Yuji Morimoto
Journal of clinical anesthesia, 59, 44, 45, Feb. 2020, [Peer-reviewed], [International Magazine]
English - Anesthetic management by blockage of thoracoabdominal nerves through perichondrial approach (TAPA) for open nephrectomy in a pediatric patient with Wilms tumor.
Nobuhiro Tanaka, Yasunori Yagi, Katsuhiro Aikawa, Yuji Morimoto
Journal of clinical anesthesia, 59, 51, 52, Feb. 2020, [Peer-reviewed], [International Magazine]
English - Two-stage goal-directed therapy protocol for non-donor open hepatectomy: an interventional before-after study.
Kazuyuki Mizunoya, Tomoaki Fujii, Masataka Yamamoto, Nobuhiro Tanaka, Yuji Morimoto
Journal of anesthesia, 33, 6, 656, 664, Dec. 2019, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, PURPOSE: Hemodynamic management during low central venous pressure (L-CVP)-assisted hepatectomy involves fluid restriction during resection and fluid resuscitation after resection. Recently, high stroke volume variation (SVV) has been reported as an alternative to L-CVP for reducing blood loss during a hepatectomy. The current study evaluated the impact of a newly implemented SVV-based goal-directed therapy (GDT) protocol on blood loss during hepatectomy. METHODS: We conducted a before-after comparative study, which included L-CVP-assisted hepatectomy cases (control group) and GDT-assisted hepatectomy cases (intervention group). The GDT protocol included SVV, cardiac index, and mean arterial pressure as hemodynamic parameters. The target SVV ranges were ≥ 13% and ≤ 12% before and after the resection, respectively. The primary endpoint was the proportion of patients whose blood loss was < 400 mL (median of our hepatectomy cases) in the GDT group, and it was compared to a predefined threshold of 50%. We also investigated factors associated with blood loss using multiple regression analysis. RESULTS: We included 66 patients in the control group and 50 in the GDT group. In the GDT group, the median blood loss was 220 mL and 36 patients (72%) lost < 400 mL blood. This was significantly greater than 50% (P < 0.001). Post-resection GDT-guided fluid optimization reduced positive intraoperative fluid balance compared to that achieved by the conventional fluid therapy used in the control. Multiple regression analysis showed that GDT application, epidural anesthesia, operative time, and hydroxyethyl-starch infusion volume were associated with blood loss. CONCLUSION: Compared to conventional management, SVV-guided GDT may reduce blood loss during hepatectomies. - Changes of Cerebral Blood Volume During Robot-Assisted Laparoscopic Radical Prostatectomy: Observational Prospective Study Using Near-Infrared Time-Resolved Spectroscopy.
Nobuhiro Tanaka, Masataka Yamamoto, Takashige Abe, Takahiro Osawa, Ryuji Matsumoto, Nobuo Shinohara, Hitoshi Saito, Yosuke Uchida, Yuji Morimoto
Journal of endourology, 33, 12, 995, 1001, Dec. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Purpose:
Robot-assisted laparoscopic radical prostatectomy (RARP) requires a steep head-down tilt and pneumoperitoneum, which may cause an increase in cerebral blood volume (CBV). With a new near-infrared time-resolved spectroscopy device, the tNIRS-1, we can measure the absolute value of the cerebral hemoglobin concentration and hence calculate CBV and cerebral oxygen saturation (rSO2). Using this device, we evaluated the time course of CBV during surgery and also evaluated the changes in rSO2 simultaneously.
Materials and Methods:
We performed a prospective observational study of 21 patients scheduled for RARP. We evaluated CBV and rSO2 by using the tNIRS-1 at 10 time points during surgery.
Results:
The CBV was 2.92 ± 0.38 mL ·100 g-1 after the end of anesthetic preparation. It significantly increased to 3.05 ± 0.44 mL ·100 g-1 after the head-down tilt and was around 3.1 mL ·100 g-1 until 120 minutes after the head-down tilt. However, just before the return to the horizontal position, it decreased to 2.93 ± 0.46 mL ·100 g-1 and then decreased more after the return to the horizontal position. Changes in rSO2 over time were within only 3%, and no significant differences from the control value were observed.
Conclusions:
The increase in CBV was <10% despite the steep head-down tilt and pneumoperitoneum, and it was compensated for at around the end of surgery. Clinically significant changes in rSO2 were not observed during the surgery. - A pediatric cancer patient with suspected chemical coping following high-dose opioid therapy: a case report.
Mototsugu Miura, Kenkichi Tsuruga, Yuji Morimoto
Journal of medical case reports, 13, 1, 353, 353, 30 Nov. 2019, [International Magazine]
English, Scientific journal, BACKGROUND: Chemical coping is an inappropriate method for dealing with stress through the use of opioids; it is considered the stage prior to abuse and dependence. In patients with cancer, it is important to evaluate the risk of chemical coping when using opioids. There are some pediatric opioid use-related tolerances and addictions; however, no mention of chemical coping has been found. CASE PRESENTATION: We present a case of an 11-year-old Japanese boy with acute lymphocytic leukemia. After transplantation, he complained of abdominal and articular pain, which are considered as symptoms of graft-versus-host disease; thus, opioid therapy was initiated, and the dose was gradually increased for pain management, resulting in a high dose of 2700 μg/day of fentanyl (4200-4700 μg/day including the rescue dose). After switching from fentanyl to oxycodone injections, he continued to experience pain, and there was no change in the frequency of oxycodone rescue doses. Physically, his pain was considered to have alleviated; thus, there was the possibility of mental anxiety resulting in the lowering of pain threshold and the possibility of chemical coping. Mental anxiety and stress with progress through schooling was believed to have resulted in chemical coping; thus, efforts were made to reduce the boy's anxiety, and opioid education was provided. However, dose reduction was challenging. Ultimately, with guidance from medical care providers, the opioid dose was reduced, and the patient was successfully weaned off opioids. CONCLUSIONS: When chemical coping is suspected in pediatric patients, after differentiating from pseudo-addiction, it might be necessary to restrict the prescription for appropriate use and to provide opioid education while taking into consideration the emotional background of the patient that led to chemical coping. - Acute compartment syndrome of the lower leg causing cardiac arrest after resection of the right external iliac vein for autologous graft: a case report.
Koji Hoshino, Toru Nakamura, Mineji Hayakawa, Yusuke Itosu, Hitoshi Saito, Satoshi Hirano, Yuji Morimoto
JA clinical reports, 5, 1, 65, 65, 23 Oct. 2019, [International Magazine]
English, Scientific journal, BACKGROUND: The right external iliac vein (REIV) is often used for portal vein reconstruction in patients undergoing pancreatoduodenectomy with portal-superior mesenteric vein resection. We report a case of cardiac arrest caused by acute lower leg compartment syndrome as a result of REIV resection. CASE PRESENTATION: A 53-year-old man underwent pancreatoduodenectomy with portal vein resection. Hyperkalemia progressed during surgery due to intestinal reperfusion injury, which caused recurrent ventricular arrhythmia required for cardio-pulmonary resuscitation. The surgery was discontinued after resuscitation, and portal vein reconstruction using the REIV was performed 2 days post-operatively. Acute compartment syndrome was diagnosed immediately following the surgery. Hyperkalemia progressed, causing pulseless ventricular tachycardia. Emergent fasciotomy was performed, but right leg dysfunction persisted after discharge. CONCLUSION: REIV resection can cause lower-extremity acute compartment syndrome. The status, including intracompartmental pressure, of the lower extremity should be carefully observed after REIV resection during and after surgery. - 不可逆的な高度心機能低下を呈した副腎外褐色細胞腫症例に対する麻酔経験
副島 崇旨, 水野谷 和之, 安藤 義崇, 斉藤 仁志, 森 敏洋, 森本 裕二
麻酔, 68, 10, 1099, 1102, 克誠堂出版(株), Oct. 2019, [Peer-reviewed]
Japanese - Modified TAPAを用いて麻酔管理を行った腹腔鏡下スリーブ状胃切除術2例に関する検討
相川 勝洋, 田中 暢洋, 森本 裕二
日本臨床麻酔学会誌, 39, 6, S244, S244, 日本臨床麻酔学会, Oct. 2019, [Peer-reviewed]
Japanese - 【血圧】血圧をあやつる 高血圧による合併症と対処法
森 敏洋, 森本 裕二
LiSA 別冊, 26, 別冊'19秋号, 207, 212, (株)メディカル・サイエンス・インターナショナル, Sep. 2019
Japanese - 小児開心術における中枢神経障害 麻酔薬の中枢神経毒性
斉藤 仁志, 内田 洋介, 干野 晃嗣, 打浪 有可, 森本 裕二
Cardiovascular Anesthesia, 23, Suppl., [SY4, 3], (一社)日本心臓血管麻酔学会, Sep. 2019, [Peer-reviewed]
Japanese - 生体肺移植待機中に膜型人工肺(V-V ECMO)が導入された患者に高流量鼻カヌラ療法(HFNC)を併用することによって安全に麻酔導入が出来た一症例
黒川 達哉, 田中 暢洋, 坂井 俊朗, 糸洲 佑介, 斉藤 仁志, 森本 裕二
Cardiovascular Anesthesia, 23, Suppl., [DP2, 01], (一社)日本心臓血管麻酔学会, Sep. 2019, [Peer-reviewed]
Japanese - Changes in cerebral oxygen saturation during one-lung ventilation determined using spatially resolved spectroscopy and contributing factors.
Tanaka N, Katoh RI, Yamamoto M, Hoshino K, Morimoto Y, Ito YM, Kato T
Journal of clinical anesthesia, 59, 99, 100, Jul. 2019, [Peer-reviewed]
English - 【小児麻酔のいま】麻酔薬の神経毒性 その基礎と臨床、過去と未来
斉藤 仁志, 内田 洋介, 森本 裕二
臨床麻酔, 43, 6, 790, 798, 真興交易(株)医書出版部, Jun. 2019
Japanese - Anesthetic management for cesarean section in a patient receiving transplacental treatment of fetal tachyarrhythmia: a case report.
Nobuhiro Tanaka, Tomoaki Fujii, Niina Mikami, Yuka Uchinami, Hitoshi Saito, Yuji Morimoto
JA clinical reports, 5, 1, 31, 31, 07 May 2019, [International Magazine]
English, Scientific journal, BACKGROUND: Although rare, long-lasting fetal tachyarrhythmia often leads to fetal heart failure and hydrops. Some mothers receive transplacental treatment of fetal tachyarrhythmia (TTFT), which can potentially worsen maternal hypotension and bradycardia. Moreover, the use of rescue cardiovascular agents intraoperatively can worsen fetal tachycardia. However, reports of the anesthetic management of patients receiving TTFT are rare. CASE PRESENTATION: A 31-year-old woman who was receiving digoxin and sotalol for TTFT underwent planned elective cesarean section. The fetus had hypoplastic left heart syndrome, hydrops, and tachycardia. We used combined spinal-epidural anesthesia with a reduced dose of local anesthetic. We also employed a non-invasive continuous hemodynamic monitoring system. The mother's systolic blood pressure remained at ≥ 90% of the baseline value; intraoperative administration of rescue cardiovascular agents was not required. CONCLUSIONS: We successfully anesthetized a woman for cesarean section, who was receiving TTFT for fetal tachyarrhythmia, using combined spinal-epidural anesthesia and non-invasive continuous hemodynamic monitoring. - 幼児の神経芽腫に合併した可逆性脳血管攣縮症候群の1症例
土岐 崇幸, 干野 晃嗣, 武田 圭史, 西川 直樹, 斉藤 仁志, 森本 裕二
日本集中治療医学会雑誌, 26, 3, 199, 200, (一社)日本集中治療医学会, May 2019, [Peer-reviewed]
Japanese - A case of complex regional pain syndrome (CRPS) to whom shichimotsukokato was effective against allodynia
FUJII Tomoaki, MIURA Mototsugu, HASE Tetsutaro, TSURUGA Kenkichi, MORIMOTO Yuji
Journal of Japan Society of Pain Clinicians, 26, 1, 36, 39, Japan Society of Pain Clinicians, 2019
Japanese,Complex regional pain syndrome (CRPS) accompanies allodynia. Allodynia impairs the quality of life in chronic pain patients and is often difficult to treat. It has been suggested that yokukansan has an anti-allodynic effect. In this case report, shichimotsukokato was administered to a patient with CRPS who could not continue to take yokukansan. Shichimotsukokato provided the same anti-allodynic effect as yokukansan. Shichimotsukokato contains chotoko, which is the active constituent leading to anti-allodynia action in yokukansan. This case suggests that shichimotsukokato may offer similar anti-allodynia effect as yokukansan.
- Isoflurane induced c-Fos expression in the area postrema of the rat.
Hase T, Hashimoto T, Saito H, Uchida Y, Kato R, Tsuruga K, Takita K, Morimoto Y
Journal of Anesthesia, 33, 4, 562, 566, 2019, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, INTRODUCTION: Volatile anesthetics are speculated to cause postoperative nausea and vomiting via stimulation of the chemoreceptor trigger zone (CTZ). However, the precise mechanism underlying the emetic action of these drugs is not well understood. In this study, we assessed whether isoflurane induced the expression of c-Fos, a neuronal activation marker, in the area postrema (AP), the locus of the CTZ, in rats, which do not have vomiting action. MATERIALS AND METHODS: Male rats were exposed to 1.3% isoflurane for 0-240 min, or to various concentrations of isoflurane (0, 1.3%, or 2.6%) for 120 min. Finally, the rats were exposed to 1.3% isoflurane for 120 min after ondansetron administration. After the treatments, immunohistochemistry of the rat AP was performed using c-Fos antibody staining. RESULTS: One-way analysis of variance showed that isoflurane exposure significantly increased c-Fos expression in the AP; however, the rats pretreated with 4 mg/kg ondansetron showed significantly decreased c-Fos expression. Moreover, we evaluated the effect of the anesthetic on inducing pica in the rats, and found that kaolin intake was not influenced by isoflurane exposure. CONCLUSION: Overall, these results suggest that isoflurane activates AP neurons and may be involved in the emetic mechanism of isoflurane. This study further suggests the feasibility of using rats as a model for studying emetic mechanisms of drugs, despite their lack of vomit action. - Anesthetic management with subcostal transversus abdominis plane block in recessive dystrophic epidermolysis bullosa for peritoneal dialysis catheter replacement: a case report
Katsuhiro Aikawa, Nobuhiro Tanaka, Yuji Morimoto
JA Clinical Reports, 4, 1, Springer Science and Business Media LLC, Dec. 2018
Scientific journal - 脊柱起立筋面ブロックを用いて管理した胸筋温存乳房切除術3症例についての検討
伊藤 智樹, 相川 勝洋, 安藤 貴士, 森本 裕二
日本臨床麻酔学会誌, 38, 6, S265, S265, 日本臨床麻酔学会, Oct. 2018
Japanese - 胸部外科手術においてretrolaminar blockを施行した一例
田中 暢洋, 村上 仁志, 森本 裕二
日本小児麻酔学会誌, 24, Suppl., 148, 148, 日本小児麻酔学会, Oct. 2018, [Peer-reviewed]
Japanese - 先天性心疾患を有する児の脳循環 酸素化障害の有無での検討
山本 真崇, 森 敏洋, 森本 裕二
Cardiovascular Anesthesia, 22, Suppl., 174, 174, (一社)日本心臓血管麻酔学会, Sep. 2018
Japanese - 腎静脈内腫瘍に対する根治的腎摘出術中に発症した肺動脈塞栓症の一例
松村 優, 武田 圭史, 田中 暢洋, 森 敏洋, 森本 裕二
Cardiovascular Anesthesia, 22, Suppl., 248, 248, (一社)日本心臓血管麻酔学会, Sep. 2018, [Peer-reviewed]
Japanese - Evaluation of external reference levels for central venous pressure measurements of severely obese patients in the supine position
Kazuyuki Mizunoya, Hitoshi Saito, Yuji Morimoto
Journal of Anesthesia, 32, 4, 1, 7, Springer Tokyo, 28 May 2018, [Peer-reviewed]
English, Scientific journal - ゲンタマイシン吸入が奏功した気管支拡張症急性増悪の一例
武田 圭史, 土岐 崇幸, 干野 晃嗣, 斉藤 仁志, 柳田 雄一郎, 森本 裕二
日本集中治療医学会雑誌, 25, 3, 185, 189, (一社)日本集中治療医学会, May 2018, [Peer-reviewed]
Japanese - Vasoactive-inotropic score as a predictor of morbidity and mortality in adults after cardiac surgery with cardiopulmonary bypass.
Yumiko Yamazaki, Koji Oba, Yoshiro Matsui, Yuji Morimoto
Journal of anesthesia, 32, 2, 167, 173, Apr. 2018, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, PURPOSE: The vasoactive-inotropic score (VIS) is a scale showing the amount of vasoactive and inotropic support. Recently, it was suggested that the VIS after cardiac surgery predicts morbidity and mortality in infants. The purpose of this study was to evaluate the VIS at the end of surgery as a predictor of morbidity and mortality in adult cardiac surgery. METHODS: A retrospective cohort study of 129 adult cardiac surgery patients was performed at a university hospital. The primary outcome was termed "poor outcome", which was a composite of morbidity and mortality. The secondary outcomes were the duration of intensive care unit (ICU) stay and time to first extubation. Multivariate logistic regression analysis was performed to evaluate the association between the VIS and poor outcomes. A proportional hazards model was used to evaluate the duration of the ICU stay and time to first extubation. RESULTS: After adjusting for the EuroSCORE, preoperative ejection fraction, and bypass time, a high VIS at the end of surgery was associated with a poor outcome with an adjusted odds ratio of 4.87 (95% confidence interval 1.51-18.94; p = 0.007). After controlling for the EuroSCORE and bypass time, patients with a high VIS experienced longer ICU stay (hazard ratio 1.62; 95% confidence interval 1.10-2.39; p = 0.015) and needed longer ventilation (hazard ration 1.87; 95% confidence interval 1.28-2.74, p = 0.001). CONCLUSIONS: The amount of cardiovascular support at the end of cardiac surgery may predict morbidity and mortality in adults. - Systolic Anterior Motion of the Mitral Valve During Pulmonary Endarterectomy in a Patient with Chronic Thromboembolic Pulmonary Hypertension
Koji Hoshino, Koichi Takita, Masami Demura, Tomonori Kubo, Yuji Morimoto
Journal of Cardiothoracic and Vascular Anesthesia, 32, 2, 807, 810, W.B. Saunders, 01 Apr. 2018, [Peer-reviewed]
English, Scientific journal - Influence of nitrous oxide on granule cell migration in the dentate gyrus of the neonatal rat
Hitoshi Saito, Rui Kato, Toshikazu Hashimoto, Yosuke Uchida, Tetsutaro Hase, Kenkichi Tsuruga, Koichi Takita, Yuji Morimoto
Biomedical Research (Japan), 39, 1, 39, 45, Biomedical Research Foundation, 2018, [Peer-reviewed]
English, Scientific journal - Sevoflurane inhibits presynaptic calcium influx without affecting presynaptic action potentials in hippocampal CA1 region.
Hasegawa K, Kamiya H, Morimoto Y
Biomedical research (Tokyo, Japan), 39, 5, 223, 230, 2018, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Although diverse effects of volatile anesthetics have been investigated in various studies, the mechanisms of action of such anesthetics, especially sevoflurane, remain elusive. In contrast to their potent modulation of inhibitory synaptic transmission there is little information about their effects on excitatory transmission in the brain. In this study, we examined the effect of sevoflurane on the excitatory synaptic transmission at CA1 synapses in hippocampal slices of mice. Sevoflurane at 5% was mixed with 95% O2 and 5% CO2 and bubbled in artificial cerebral spinal fluid (0.69 mM). Extracellular recordings of the field excitatory postsynaptic potential (fEPSP) and presynaptic fiber volley (FV) were made at physiological temperature. In addition, fluorescent measurements of presynaptic Ca2+ transients were performed while simultaneously recording fEPSP. Application of sevoflurane reduced the amplitude of fEPSP (45 ± 8%, n = 5). This effect was accompanied by concurrent enhancement of the paired-pulse facilitation of fEPSP (127 ± 5%, n = 12), suggesting a possible presynaptic site of action of sevoflurane. The amplitude of FV was not significantly affected (102 ± 5%, n = 5). In contrast, fluorescent measurements revealed that presynaptic Ca2+ influx was suppressed by sevoflurane (69 ± 5%, n = 7), as was simultaneously recorded fEPSP (44 ± 5%, n = 7). Our results suggest that sevoflurane potently suppresses excitatory synaptic transmission via inhibition of presynaptic Ca2+ influx without affecting presynaptic action potentials. - 人工気胸併用腹臥位の食道癌手術においてEZブロッカーが有用だった症例
浜谷 絵里, 藤田 憲明, 土岐 崇幸, 森本 裕二
日本臨床麻酔学会誌, 37, 6, S310, S310, 日本臨床麻酔学会, Oct. 2017
Japanese - 経胎盤的抗不整脈投与療法中の母体の帝王切開においてクリアサイトを用いて管理をした1症例の麻酔経験
三上 仁衣奈, 打浪 有可, 田中 暢洋, 斉藤 仁志, 森本 裕二
日本臨床麻酔学会誌, 37, 6, S291, S291, 日本臨床麻酔学会, Oct. 2017, [Peer-reviewed]
Japanese - 双胎間輸血症候群に対する胎児鏡下胎盤吻合血管レーザー凝固術の周術期管理についての検討
長谷川 栄, 打浪 有可, 斉藤 仁志, 田中 暢洋, 森本 裕二
日本臨床麻酔学会誌, 37, 6, S296, S296, 日本臨床麻酔学会, Oct. 2017, [Peer-reviewed]
Japanese - 幼若期ストレスによるラットのうつ様行動に対するケタミンの効果とその神経基盤研究
相川 勝洋, 吉田 隆行, 大村 優, 泉 剛, 吉岡 充弘, 森本 裕二
日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 39回・47回, 163, 163, 日本生物学的精神医学会・日本神経精神薬理学会, Sep. 2017
Japanese - MINOCYCLINE PREVENTS THE IMPAIRMENT OF HIPPOCAMPAL LONG-TERM POTENTIATION IN THE SEPTIC MOUSE
Koji Hoshino, Mineji Hayakawa, Yuji Morimoto
SHOCK, 48, 2, 209, 214, Aug. 2017, [Peer-reviewed]
English, Scientific journal - Changes of Cerebral Oxygenation in Sequential Glenn and Fontan Procedures in the Same Children
Yasunori Yagi, Masataka Yamamoto, Hitoshi Saito, Toshihiro Mori, Yuji Morimoto, Takayoshi Oyasu, Tsuyoshi Tachibana, Yoichi M. Ito
PEDIATRIC CARDIOLOGY, 38, 6, 1215, 1219, Aug. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal - Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit
Yasunobu Arima, Takuto Ohki, Naoki Nishikawa, Kotaro Higuchi, Mitsutoshi Ota, Yuki Tanaka, Junko Nio-Kobayashi, Mohamed Elfeky, Ryota Sakai, Yuki Mori, Tadafumi Kawamoto, Andrea Stofkova, Yukihiro Sakashita, Yuji Morimoto, Masaki Kuwatani, Toshihihiko Iwanaga, Yoshichika Yoshioka, Naoya Sakamoto, Akihiko Yoshimura, Mitsuyoshi Takiguchi, Saburo Sakoda, Marco Prinz, Daisuke Kamimura, Masaaki Murakami
ELIFE, 6, Aug. 2017, [Peer-reviewed]
English, Scientific journal - 近赤外時間分解分光法による麻酔導入時の経時的脳血液量変化測定
副島 崇旨, 山本 真崇, 田中 暢洋, 森本 裕二
日本神経麻酔集中治療学会プログラム・抄録集, 21回, 35, 35, 日本神経麻酔集中治療学会, Jun. 2017, [Peer-reviewed]
Japanese - Laboratory findings: To what degree can we extrapolate the animal data to the bedside?
Yuji Morimoto, Yosuke Uchida, Hitoshi Saito
Anesthesia and Neurotoxicity, 3, 15, Springer Japan, 30 May 2017, [Peer-reviewed]
English, In book - Comparison of the analgesic efficacy of ultrasound-guided rectus sheath block and local anesthetic infiltration for laparoscopic percutaneous extraperitoneal closure in children
Yuka Uchinami, Fumika Sakuraya, Nobuhiro Tanaka, Koji Hoshino, Eri Mikami, Taro Ishikawa, Hitomi Fujii, Takehiko Ishikawa, Yuji Morimoto
PEDIATRIC ANESTHESIA, 27, 5, 516, 523, May 2017, [Peer-reviewed]
English, Scientific journal - Synapse-specific effects of IL-1 beta on long-term potentiation in the mouse hippocampus
Koji Hoshino, Kan Hasegawa, Haruyuki Kamiya, Yuji Morimoto
BIOMEDICAL RESEARCH-TOKYO, 38, 3, 183, 188, 2017, [Peer-reviewed]
English, Scientific journal - Left subclavian artery malperfusion due to thoracic outlet syndrome during total vertebrectomy for invasive lung cancer: a case report.
Mizunoya K, Ueda K, Takeda Y, Takita K, Morimoto Y
JA clinical reports, 3, 1, 61, 61, 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, Thoracic outlet syndrome (TOS) can interrupt blood flow to upper limbs by vascular compression. We report a case of a 52-year-old man who presented left subclavian artery malperfusion due to TOS during total vertebrectomy (Th2-4) in the prone position for invasive lung cancer. At the time of resection of the vertebral bodies, his left radial systolic blood pressure had begun to drop intermittently and we noticed an interarm pressure difference. Accordingly, we began to monitor the right radial artery pressure and found that only the left radial artery pressure decreased as a result of compressive force from the surgical site. The operation was continued with intermittent malperfusion of the left arm, and when it was prolonged, we asked the surgeons to release the compression. No symptoms of ischemia or nerve injuries in the left arm were observed after the surgery. Retrospective review of his preoperative enhanced computed tomography images suggested a slightly compressed left subclavian artery in the costoclavicular space. Combination of the prone position and a specific upper limb position may be a risk factor for intraoperative TOS. An interarm blood pressure difference is a clue to detect accidental arterial TOS during general anesthesia. - Interference between M-entropy and thermistor probe fixed on the forehead during general
Kazuyuki Mizunoya, Takeshi Yokoyama, Katsuyuki Katayama, Yuji Morimoto
Japanese Journal of Anesthesiology, 65, 12, 1279, 1281, Kokuseido Publishing Co. Ltd, 01 Dec. 2016
Japanese, Scientific journal - 人工心肺を使用した心臓手術後の急性腎傷害に関する検討
水野谷 和之, 横山 健, 川名 信, 片山 勝之, 森本 裕二
日本集中治療医学会雑誌, 23, 2, 141, 147, (一社)日本集中治療医学会, Mar. 2016
Japanese - 人工膝関節置換術における関節周囲浸潤麻酔と坐骨神経ブロックの効果に関する検討
相川 勝洋, 橋本 聡一, 糸洲 佑介, 藤井 知昭, 堀口 貴行, 雨森 英彦, 森本 裕二
麻酔, 65, 1, 50, 55, 克誠堂出版(株), Jan. 2016
Japanese - [症例]急性一酸化炭素中毒に対する高気圧酸素治療経験
本間多恵子, 柳田雄一郎, 石川岳彦, 森本裕二, 石川勝清, 丸藤哲
ICUとCCU, 40, 61, 64, 2016, [Peer-reviewed]
Japanese, Scientific journal - Comparison of the effect of periarticular infiltration analgesia versus sciatic nerve block for total knee arthroplasty
Katsuhiro Aikawa, Toshikazu Hashimoto, Yusuke Itosu, Tomoaki Fujii, Takayuki Horiguchi, Hidehiko Amenomori, Yuji Morimoto
Japanese Journal of Anesthesiology, 65, 1, 50, 55, Kokuseido Publishing Co. Ltd, 01 Jan. 2016, [Peer-reviewed]
Japanese, Scientific journal - Plantar injection of formalin in rats reduces the expression of a potassium chroride cotransporter KCC2 in the spinal cord and a kinase inhibitor suppresses this reduction
Kenkichi Tsuruga, Toshikazu Hashimoto, Ryoko Kato, Rui Kato, Yousuke Uchida, Tetsutaro Hase, Yuji Morimoto
BIOMEDICAL RESEARCH-TOKYO, 37, 4, 243, 249, 2016, [Peer-reviewed]
English, Scientific journal - フォンタン型手術時の脳ならびに末梢動脈血酸素飽和度と短期予後との関係
山本 真崇, 八木 泰憲, 森 敏洋, 森本 裕二
Cardiovascular Anesthesia, 19, Suppl., 222, 222, (一社)日本心臓血管麻酔学会, Oct. 2015
Japanese - 未根治チアノーゼ型先天性心疾患に対する肺葉切除術の麻酔経験
森 敏洋, 藤田 憲明, 森本 裕二
Cardiovascular Anesthesia, 19, Suppl., 250, 250, (一社)日本心臓血管麻酔学会, Oct. 2015
Japanese - 同一患者におけるグレン-フォンタン手術時の脳酸素飽和度変化
八木 泰憲, 山本 真崇, 森 敏洋, 森本 裕二
Cardiovascular Anesthesia, 19, Suppl., 284, 284, (一社)日本心臓血管麻酔学会, Oct. 2015
Japanese - Examination of the influence of age and cardiopulmonary bypass on cerebral autoregulation in pediatric patients for the cardiac surgery by using near-infrared spectroscopy
Koji Hoshino, Naoki Nishimoto, Yuji Morimoto
Japanese Journal of Anesthesiology, 64, 9, 960, 965, Kokuseido Publishing Co. Ltd, 01 Sep. 2015, [Peer-reviewed]
Japanese, Scientific journal - Neurotoxicity of anesthetic agents for developing and adult brain
Rui Kato, Toshikazu Hashimoto, Yuji Morimoto
Neuroanesthesia and Cerebrospinal Protection, 127, 137, Springer Japan, 07 Aug. 2015, [Peer-reviewed]
English, In book - 小児腹腔鏡下鼠径ヘルニア日帰り手術の術後鎮痛法 超音波ガイド下腹直筋鞘ブロックvs局所浸潤麻酔
打浪 有可, 石川 太郎, 田中 暢洋, 櫻谷 文香, 三上 惠理, 藤井 ひとみ, 森本 裕二
日本小児麻酔学会誌, 21, 1, 115, 115, 日本小児麻酔学会, Aug. 2015, [Peer-reviewed]
Japanese - 新生児期における先天性嚢胞性腺腫様奇形に対する肺切除術2例の麻酔管理
田中 暢洋, 加藤 亮子, 瀧田 恒一, 森本 裕二
日本小児麻酔学会誌, 21, 1, 203, 207, 日本小児麻酔学会, Aug. 2015
Japanese - A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model
Yasunobu Arima, Daisuke Kamimura, Toru Atsumi, Masaya Harada, Tadafumi Kawamoto, Naoki Nishikawa, Andrea Stofkova, Takuto Ohki, Kotaro Higuchi, Yuji Morimoto, Peter Wieghofer, Yuka Okada, Yuki Mori, Saburo Sakoda, Shizuya Saika, Yoshichika Yoshioka, Issei Komuro, Toshihide Yamashita, Toshio Hirano, Marco Prinz, Masaaki Murakami
ELIFE, 4, Aug. 2015, [Peer-reviewed]
English, Scientific journal - Perioperative management of a patient with severe Parkinson's disease with intravenous levodopa administration
Satoko Terashima, Yurina Yanagida, Akira Watabe, Masahiro Yamane, Yuji Morimoto
Japanese Journal of Anesthesiology, 64, 8, 845, 848, Kokuseido Publishing Co. Ltd, 01 Aug. 2015, [Peer-reviewed]
Japanese, Scientific journal - スガマデクス投与後、冠攣縮による心停止を繰り返し発症した1症例
干野 晃嗣, 加藤 類, 長沢 紗也香, 神津 将仁, 森本 裕二
麻酔, 64, 6, 622, 627, 克誠堂出版(株), Jun. 2015, [Peer-reviewed]
Japanese - I-131治療後の放射線性耳下腺炎による顔面の痛みに高気圧酸素治療が有効であった1例
長谷 徹太郎, 内田 洋介, 長谷川 完, 田中 暢洋, 敦賀 健吉, 森本 裕二
日本ペインクリニック学会誌, 22, 3, 443, 443, (一社)日本ペインクリニック学会, Jun. 2015, [Peer-reviewed]
Japanese - A case of repetitive cardiac arrest due to coronary vasospasm after sugammadex administration
Koji Hoshino, Rui Kato, Sayaka Nagasawa, Masahito Kozu, Yuji Morimoto
Japanese Journal of Anesthesiology, 64, 6, 622, 627, Kokuseido Publishing Co. Ltd, 01 Jun. 2015, [Peer-reviewed]
Japanese, Scientific journal - チアノーゼ性および非チアノーゼ性先天性心疾患の小児手術における脳の酸素飽和度の変化(Changes in cerebral oxygen saturation during pediatric surgery in patients with cyanotic and non-cyanotic congenital heart defects)
Tanaka Nobuhiro, Tokuyama Hideo, Uchida Yosuke, Morimoto Yuji, Tachibana Tsuyoshi
循環制御, 36, 1, 18, 24, 日本循環制御医学会, Apr. 2015
English - SensiLase PAD3000を用いた星状神経節ブロック前後の皮膚灌流圧の評価
長谷 徹太郎, 加藤 類, 田中 暢洋, 長谷川 完, 内田 洋介, 敦賀 健吉, 橋本 聡一, 森本 裕二
日本ペインクリニック学会誌, 22, 1, 77, 77, (一社)日本ペインクリニック学会, Feb. 2015, [Peer-reviewed]
Japanese - Effect of age difference of cerebral oxygen saturation to predict early outcome in pediatric cardiac surgery for ventricular septal defect
Fujita Noriaki, Meguro Yasuteru, Saito Hitoshi, Tokuyama Hideo, Morimoto Yuji, Tachibana Tsuyoshi
Circ. Cont., 36, 2, 106, 110, Japan Society of Circulation Control in Medicine, 2015
Japanese - Nociceptin/orphanin FQ slows inspiratory rhythm via its direct effects on the pre-Bötzinger complex.
Takita K, Morimoto Y
Respiratory Physiology & Neurobiology, 207, 14, 21, 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal, In a previous study, we showed that in an in vitro en bloc preparation of newborn rats perfused with standard [K(+)] (6.2mM) and high [K(+)] (11.2mM) artificial cerebrospinal fluid (aCSF), nociceptin/orphanin FQ (N/OFQ) suppresses bursting of pre-inspiratory neurons with 1:1 coupling to the fictive inspiration. However, it is unclear whether the pre-Bötzinger complex (preBötC) is involved in the N/OFQ-induced slowing. Using in vitro en bloc preparations with and without the retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG) perfused with high [K(+)] aCSF, we found the following: (1) there were no differences in the effects of N/OFQ on the inspiratory rhythm between the preparations with and without the RTN/pFRG, (2) N/OFQ decreased the input resistance of inspiratory neurons (Insps) in the preparations without the RTN/pFRG and suppressed their ectopic firing activities, and (3) N/OFQ suppressed the spontaneous firing of Insps under a chemical synaptic transmission blockade. In conclusion, it is possible that the preBötC is involved in N/OFQ-induced inspiratory rhythm slowing. - Dexmedetomidine suppresses long-term potentiation in the hippocampal CA1 field of anesthetized rats
Ryoko Ito Kato, Kaori Tachibana, Toshikazu Hashimoto, Koichi Takita, Yuji Morimoto
JOURNAL OF ANESTHESIA, 28, 6, 828, 832, Dec. 2014, [Peer-reviewed]
English, Scientific journal - 糖尿病患者の脳局所酸素飽和度は、人工心肺使用時に非糖尿病患者より低値を示す
森 敏洋, 森本 裕二
Cardiovascular Anesthesia, 18, Suppl., 295, 295, (一社)日本心臓血管麻酔学会, Sep. 2014
Japanese - ROTEMを用いてTCPC conversionの麻酔管理を施行した3症例
太安 孝允, 田中 暢洋, 森 敏洋, 神津 将仁, 森本 裕二
Cardiovascular Anesthesia, 18, Suppl., 288, 288, (一社)日本心臓血管麻酔学会, Sep. 2014, [Peer-reviewed]
Japanese - 新生児期における先天性嚢胞性腺腫様奇形に対する肺切除術2例の麻酔管理
田中 暢洋, 森本 裕二
日本小児麻酔学会誌, 20, 1, 173, 173, 日本小児麻酔学会, Aug. 2014, [Peer-reviewed]
Japanese - Co-existing liver disease increases the risk of postoperative thrombocytopenia in patients undergoing hepatic resection: implications for the risk of epidural hematoma associated with the removal of an epidural catheter
Koichi Takita, Yosuke Uchida, Tetsutaro Hase, Toshiya Kamiyama, Yuji Morimoto
JOURNAL OF ANESTHESIA, 28, 4, 554, 558, Aug. 2014, [Peer-reviewed]
English, Scientific journal - 発達段階の脳に対する麻酔薬の影響
森本 裕二
医学のあゆみ, 249, 1244, 1248, 2014, [Invited] - デクスメデトミジン使用下にラリンジアルマスクに入れ替え、円滑な抜管に成功した小児喉頭気管軟化症の2症例
山崎 由美子, 斉藤 仁志, 森 敏洋, 久野 健二郎, 木田 敦知, 森本 裕二
臨床麻酔, 37, 12, 1809, 1810, 真興交易(株)医書出版部, Dec. 2013
Japanese - Neonatal exposure to sevoflurane causes significant suppression of hippocampal long-term potentiation in postgrowth rats
Rui Kato, Kaori Tachibana, Naoki Nishimoto, Toshikazu Hashimoto, Yosuke Uchida, Ryoko Ito, Kenkichi Tsuruga, Koichi Takita, Yuji Morimoto
Anesthesia and Analgesia, 117, 6, 1429, 1435, 6, Dec. 2013, [Peer-reviewed]
English, Scientific journal - 甲状腺中毒症患者に対する冠動脈バイパス術の麻酔・周術期管理の経験
水野谷 和之, 丸山 崇, 藤井 知昭, 那須 智樹, 田中 暢洋, 雨森 英彦, 橋本 聡一, 森本 裕二
麻酔, 62, 10, 1214, 1217, 克誠堂出版(株), Oct. 2013
Japanese - Anesthetic and perioperative management of a patient with uncontrolled thyrotoxicosis undergoing coronary artery bypass grafting surgery
Kazuyuki Mizunoya, Takashi Maruyama, Tomoaki Fujii, Satoki Nasu, Nobuhiro Tanaka, Hidehiko Amenomori, Toshikazu Hashimoto, Yuji Morimoto
Japanese Journal of Anesthesiology, 62, 10, 1214, 1217, 10, Oct. 2013, [Peer-reviewed]
Japanese, Scientific journal - Are routine preoperative hemostatic screening tests necessary in Japanese institutions?
Koichi Takita, Yumiko Yamazaki, Yuji Morimoto
Journal of Anesthesia, 27, 3, 481, 482, Jun. 2013, [Peer-reviewed]
English - Neonatal exposure to high concentration of carbon dioxide produces persistent learning deficits with impaired hippocampal synaptic plasticity
Kaori Tachibana, Toshikazu Hashimoto, Koichi Takita, Ryoko Ito, Rui Kato, Yuji Morimoto
BRAIN RESEARCH, 1507, 83, 90, Apr. 2013, [Peer-reviewed]
English, Scientific journal - Anesthetic management of pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension - Series of severe cases
Sayaka Nagasawa, Katsumi Harasawa, Yuji Morimoto
Japanese Journal of Anesthesiology, 61, 11, 1226, 1229, Nov. 2012
Japanese, Scientific journal - Anesthetic management of pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension - Series of severe cases
Sayaka Nagasawa, Katsumi Harasawa, Yuji Morimoto
Japanese Journal of Anesthesiology, 61, 11, 1226, 1229, 11, Nov. 2012, [Peer-reviewed]
Japanese, Scientific journal - 過去5年間の一酸化炭素中毒症例の臨床検討
本間多恵子, 本間慶憲, 山本浩, 柳田雄一郎, 上垣慎二, 久保田信彦, 早川峰司, 澤村淳, 石川岳彦, 丸藤哲, 森本裕二
日本救急医学会雑誌, 23, 10, 529, 15 Oct. 2012
Japanese - Neonatal administration with dexmedetomidine does not impair the rat hippocampal synaptic plasticity later in adulthood
Kaori Tachibana, Toshikazu Hashimoto, Rui Kato, Yosuke Uchida, Ryoko Ito, Koichi Takita, Yuji Morimoto
PEDIATRIC ANESTHESIA, 22, 7, 713, 719, Jul. 2012, [Peer-reviewed]
English, Scientific journal - Use of near-infrared spectroscopy in combination with monitoring of external jugular vein pressure for early detection of cerebral ischemia by unintentional superior vena cava obstruction
Ryoko Ito, Koichi Takita, Kazuyuki Mizunoya, Atsunori Kida, Yuji Morimoto
Journal of Cardiothoracic and Vascular Anesthesia, 26, 3, e27, e28, 3, Jun. 2012, [Peer-reviewed]
English - Survey of Patients Presented with Severely Difficult Intubation in Hokkaido University Hospital (2005-2010)
TAKITA KOICHI, MORIMOTO YUJI
麻酔, 61, 4, 418, 423, 10 Apr. 2012, [Domestic magazines]
Japanese, Scientific journal, BACKGROUND: Recently, in addition to bronchofiberscope, the new equipments to manage difficult intubation are available. However, it is unknown whether the incidence of difficult intubation decreases or not. In order to determine the incidence of severe difficult intubation, we conducted a survey of patients who presented with severely difficult intubation during 2005-2010. METHODS: From data of patients in whom tracheal intubation was attempted in the operating rooms in Hokkaido university hospital from January 2005 to December 2010, the data was collected on the patients who presented with severely difficult intubation, defined as the inability to secure tracheal intubation in less than 20 min from induction of anesthesia. RESULTS: A total of 21,982 tracheal intubations were attempted during the study period. The incidence of severely difficult intubation was 0.3% (65 intubations for 58 patients). There was no significant difference among the years in the incidence of severely difficult intubation. CONCLUSIONS: The incidence of severely difficult intubation was 0.3% in Hokkaido university hospital during 2005-2010. - Survey of patients presented with severely difficult intubation in Hokkaido University Hospital (2005-2010)
Koichi Takita, Yuji Morimoto
Japanese Journal of Anesthesiology, 61, 4, 418, 423, 4, 10 Apr. 2012, [Peer-reviewed]
Japanese, Scientific journal - Mechanism of the Protective Effect of Mild Hypothermia on Ischemic Neuronal Injury
MORIMOTO YUJI
日本臨床麻酔学会誌, 32, 1, 020, 026, 2012
Japanese - A case of lung torsion after esophagectomy
Yosuke Uchida, Satoko Ando, Atsunori Kida, Yuji Morimoto
Japanese Journal of Anesthesiology, 60, 11, 1321, 1325, 11, 10 Nov. 2011, [Peer-reviewed]
Japanese, Scientific journal - ラステリ手術閉胸時にPHクライシス様ショックを起こした1例
久保 康則, 木田 敦知, 森 敏洋, 森本 裕二
Cardiovascular Anesthesia, 15, Suppl., 189, 189, (一社)日本心臓血管麻酔学会, Oct. 2011
Japanese - Coagulation profiles following donor hepatectomy and implications for the risk of epidural hematoma associated with epidural anesthesia
Tetsutaro Hase, Koichi Takita, Toshikazu Hashimoto, Yuji Morimoto
Japanese Journal of Anesthesiology, 60, 7, 840, 845, 7, 10 Jul. 2011, [Peer-reviewed]
Japanese, Scientific journal - Long-lasting effects of neonatal pentobarbital administration on spatial learning and hippocampal synaptic plasticity
Kaori Tachibana, Toshikazu Hashimoto, Rui Kato, Kenkichi Tsuruga, Ryoko Ito, Yuji Morimoto
BRAIN RESEARCH, 1388, 69, 76, May 2011, [Peer-reviewed]
English, Scientific journal - 肝切除術後の凝固能変化と硬膜外カテーテル抜去に伴う血腫のリスク：生体肝移植ドナーでの検討．
長谷徹太郎, 瀧田恒一, 橋本聡一, 森本裕二
麻酔, 61, 840, 845, 2011
Japanese - 肝硬変合併開心術の予後と麻酔管理
田中 暢洋, 森本 裕二
日本臨床麻酔学会誌, 30, 6, S330, S330, 日本臨床麻酔学会, Oct. 2010, [Peer-reviewed]
Japanese - Effect of mild and moderate hypothermia on hypoxic injury in nearly pure neuronal culture
Yu Hua, Kenjiro Hisano, Yuji Morimoto
JOURNAL OF ANESTHESIA, 24, 5, 726, 732, Oct. 2010, [Peer-reviewed]
English, Scientific journal - Therapeutic Potentials of an Artificial Oxygen-Carrier, Liposome-Encapsulated Hemoglobin, for Ischemia/Reperfusion-Induced Cerebral Dysfunction in Rats
Jin Kakehata, Taku Yamaguchi, Hiroko Togashi, Ichiro Sakuma, Hiroshi Otani, Yuji Morimoto, Mitsuhiro Yoshioka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 114, 2, 189, 197, Oct. 2010, [Peer-reviewed]
English, Scientific journal - Effects of sevoflurane on respiratory rhythm oscillators in the medulla oblongata
Koichi Takita, Yuji Morimoto
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 173, 1, 86, 94, Aug. 2010, [Peer-reviewed]
English, Scientific journal - A comparison of acetated ringer's solution and bicarbanated ringer's solution for fluid therapy during extended hystectomy
Satoko Andou, Yuji Morimoto
Japanese Journal of Anesthesiology, 59, 8, 971, 975, 8, Aug. 2010, [Peer-reviewed]
Japanese, Scientific journal - 難治性潰瘍、骨髄炎治療の進歩 下顎骨骨髄炎に対する高気圧酸素治療の有効性
伊藤 亮子, 石川 勝清, 新田 幸絵, 加藤 類, 敦賀 健吉, 橋本 聡一, 森本 裕二
日本高気圧環境・潜水医学会雑誌, 44, 3, 148, 148, (一社)日本高気圧環境・潜水医学会, Sep. 2009
Japanese - Protective effects of the free radical scavenger edaravone against glutamate neurotoxicity in nearly pure neuronal culture
Kenjiro Hisano, Masahiko Watanabe, Yuji Morimoto
JOURNAL OF ANESTHESIA, 23, 3, 363, 369, Aug. 2009, [Peer-reviewed]
English, Scientific journal - Efficacy of partial opioid rotation of morphine to intravenous compound oxycodone for morphine : induced delirium in advanced cancer patients
TAKIGAWA Chizuko, KOMURA Yoshihiro, UEDA Keiko, MORIMOTO Yuji
Journal of Japan Society of Pain Clinicians, 16, 2, 153, 157, Japan Society of Pain Clinicians, 25 May 2009
Japanese, The efficacy of opioid rotation of 20% of morphine to intravenous compound oxycodone, while giving 80% of the original dose of morphine, for morphine-induced delirium in cancer patients was studied. Thirty-two consecutive patients who were admitted and treated with intravenous morphine and developed delirium in a palliative ward were prospectively studied. Opioids were given by patient-controlled analgesia method. The degree of delirium, pain, and sleepiness was assessed by the Japanese version of Memorial Delirium Assessment Scale (MDAS-J), face scale (FS), and the Japanese version of Schedule for Treatment Assessment Scale (STAS-J), respectively, before and 3 days after partial opioid rotation to compound oxycodone. Five patients were excluded from the analyses because of changed management of pain control (n=2) and brain metastases (n=3). The results were analyzed in the remaining 27 patients. Delirium improved after partial rotation to compound oxycodone in 21 (78%) of the 27 patients. The mean degree of delirium improved from 16.2 to 9.2 on MDAS-J, pain from 2.2 to 1.7 on FS, and sleepiness from 2.6 to 1.7 on STAS. We conclude that partial rotation of morphine to compound oxycodone is effective to improve morphine-induced delirium in patients with cancer pain. - Anesthetic management for severe aortic regurgitation in an infant repaired by Ross procedure
Akira Watabe, Hitoshi Saito, Katsumi Harasawa, Yuji Morimoto
JOURNAL OF ANESTHESIA, 23, 2, 270, 274, May 2009, [Peer-reviewed]
English, Scientific journal - Altered synaptic transmission in rat anterior cingulate cortex following peripheral nerve injury
Kaori Tachibana, Rui Kato, Kenkichi Tsuruga, Koichi Takita, Toshikazu Hashimoto, Yuji Morimoto
BRAIN RESEARCH, 1238, 53, 58, Oct. 2008, [Peer-reviewed]
English, Scientific journal - Anatomical features of the right internal jugular vein in infants and young children undergoing heart surgery for congenital disease: comparison between cyanotic and noncyanotic patients
Yuji Morimoto, Kenjiro Hisano, Koichi Takita, Toshikazu Hashimoto
JOURNAL OF ANESTHESIA, 22, 1, 1, 6, Feb. 2008, [Peer-reviewed]
English, Scientific journal - Nociceptin/orphanin FQ causes non-quantal slowing of respiratory rhythm in brainstem-spinal cord preparation from newborn rat.
Takita K, Morimoto Y
Neuroscience Letters, 443, 129, 133, 2008, [Peer-reviewed]
English, Scientific journal - Effects of propofol and halothane on long-term potentiation in the rat hippocampus after transient cerebral ischaemia
J. Kakehata, H. Togashi, T. Yamaguchi, Y. Morimoto, M. Yoshioka
EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 24, 12, 1021, 1027, Dec. 2007, [Peer-reviewed]
English, Scientific journal - Isoflurane bidirectionally modulates the paired-pulse responses in the rat hippocampal CA1 field in vivo
Kaori Tachibana, Koichi Takita, Toshikazu Hashimoto, Machiko Matsumoto, Mitsuhiro Yoshioka, Yuji Morimoto
ANESTHESIA AND ANALGESIA, 105, 4, 1006, 1011, Oct. 2007, [Peer-reviewed]
English, Scientific journal - Postoperative inflammatory reactions after coronary artery bypass grafting performed on-pump with preceding glucocorticoid therapy compared with those after grafting performed off-pump
Katsumi Harasawa, Yuji Morimoto
Japanese Journal of Anesthesiology, 56, 6, 666, 670, 6, Jun. 2007, [Peer-reviewed]
Japanese, Scientific journal - The role of laser therapy in pain management
HASHIMOTO Toshikazu, TSURUGA Kenkichi, MORIMOTO Yuji, KEMMOTSU Osamu
JJSLSM, 28, 1, 58, 67, Japan Society for Laser Surgery and Medicine, 16 Apr. 2007
Japanese, Laser therapy has been used for patients suffering from pain of various etiologies. GaAlAs diode laser and HeNe laser are commonly used for pain attenuation. The mechanisms of analgesic effect of laser irradiation have been revealed by experimental studies. Some studies indicate that laser irradiation suppresses sensory nerve conduction. The efficacy of laser therapy in pain attenuation has been reported by many clinical studies. Laser therapy seems to have great potency in the treatment of herpes zoster, postherpetic neuralgia, tension headache and lumbago. Although laser therapy is noninvasive and safe with almost no adverse effects, its strict indication and adequate duration of therapy should be considered. - Stored autologous blood from a pregnant woman showing a considerable amount of agglutinates
Junka Sekishita, Fumika Sakuraya, Katsumi Harasawa, Yuji Morimoto
Japanese Journal of Anesthesiology, 56, 3, 326, 328, 3, Mar. 2007, [Peer-reviewed]
Japanese, Scientific journal - ベッドサイド活性酸素・フリーラジカル評価システムFRAS4の使用経験.
加藤類, 小川彰子, 橋本聡一, 瀧田恒一, 森本裕二
臨床麻酔, 31, 897, 901, 2007
Japanese - 神経因性疼痛に対する酢酸フレカイニドの鎮痛効果と血中濃度の関係
山﨑浩二郎, 武隈 洋, 志賀弘康, 菅原 満, 小澤剛久, 柴田万里子, 橋本聡一, 森本裕二
ＴＤＭ研究, 23, 4, 253, 256, Oct. 2006, [Peer-reviewed]
Japanese, Scientific journal - Motor cortex stimulation for post-stroke pain using neuronavigation and evoked potentials: Report of 3 cases
Masaki Ito, Satoshi Kuroda, Kazuya Takano, Katsuhiko Maruichi, Yasuhiro Chiba, Yuji Morimoto, Yoshinobu Iwasaki
NEUROLOGICAL SURGERY, 34, 9, 919, 924, Sep. 2006, [Peer-reviewed]
Japanese, Scientific journal - Electrophysiological and neurochemical characterization of the effect of repeated treatment with milnacipran on the rat serotonergic and noradrenergic systems
Kaori Tachibana, Machiko Matsumoto, Hiroyo Koseki, Hiroko Togashi, Taku Kojima, Yuji Morimoto, Mitsuhiro Yoshioka
JOURNAL OF PSYCHOPHARMACOLOGY, 20, 4, 562, 569, Jul. 2006, [Peer-reviewed]
English, Scientific journal - Life-saving detection of right hemothorax by transesophageal echocardiography after femorofemoral bypass
K Harasawa, T Maruyama, Y Morimoto
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 20, 2, 229, 231, Apr. 2006, [Peer-reviewed]
English, Scientific journal - Gastric intramucosal perfusion during descending aortic repair under femoro-femoral bypass
K Tachibana, K Hisano, F Sakuraya, SJ Tang, N Shiiya, T Hashimoto, K Takita, Y Morimoto
ASAIO JOURNAL, 52, 1, 92, 95, Jan. 2006, [Peer-reviewed]
English, Scientific journal - Performance of a tonometer for arterial pressure measurement during anesthesia in the elderly
Katsumi Harasawa, Masahiro Yamane, Yuji Morimoto, Osamu Kemmotsu
Journal of Anesthesia, 18, 4, 316, 317, 4, Nov. 2004, [Peer-reviewed]
English, Scientific journal - Milnacipran, a serotonin and noradrenaline reuptake inhibitor, suppresses long-term potentiation in the rat hippocampal CA1 field via 5-HT1A receptors and alpha(1)-adrenoceptors
K Tachibana, M Matsumoto, H Togashi, T Kojima, Y Morimoto, O Kemmotsu, M Yoshioka
NEUROSCIENCE LETTERS, 357, 2, 91, 94, Mar. 2004, [Peer-reviewed]
English, Scientific journal - Successes and failures with the laryngeal mask airway (LMA) in patients with Treacher Collins syndrome - a case series
K Takita, S Kobayashi, M Kozu, Y Morimoto, O Kemmotsu
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 50, 9, 969, 970, Nov. 2003, [Peer-reviewed]
English - The height-based formula for prediction of left-sided double-lumen tracheal tube depth
K Takita, Y Morimoto, O Kemmotsu
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 17, 3, 412, 413, Jun. 2003, [Peer-reviewed]
English - Diagnosis and treatment of pulmonary embolism in Sapporo City General Hospital
HAYAKAWA Mineji, GANDO Satoshi, SATO Tomoyuki, KUBO Kouzou, HOSINO Hirokatsu, KAMEUE Takashi, MORIMOTO Yuji, MATSUBARA Izumi
日本集中治療医学会雑誌 = Journal of the Japanese Society of Intensive Care Medicine, 10, 2, 129, 130, 日本集中治療医学会, 01 Apr. 2003
Japanese, 肺塞栓症(pulmonary embolism, PE)の治療については明確な指針はなく,PEの原因である深部静脈血栓症(deepvein thrombosis, DVT)に関しても,統一された見解は得られていない。さらに最近は,下大静脈フィルター(inferiorvena cava filter, Filter)や,経皮的血栓除去カテーテル の開発によりPE治療の選択の幅が広がってきた。今回,当施設におけるPEの診断と治療法を若干の文献的考察を加え報告する。 - The ED95 of end-tidal sevoflurane concentration for the smooth exchange of the tracheal tube for a laryngeal mask airway is 2.97%
K Takita, M Yamane, Y Morimoto, O Kemmotsu
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 50, 2, 184, 188, Feb. 2003, [Peer-reviewed]
English, Scientific journal - Anesthetic management for cesarian section in a patient with mitral stenosis and severe pulmonary hypertension
Nobuhiko Kubota, Yuji Morimoto, Osamu Kemmotsu
Japanese Journal of Anesthesiology, 52, 2, 177, 179, 2, 01 Feb. 2003, [Peer-reviewed]
Japanese, Scientific journal - Three Patients with Fulminant Hepatic Failure Treated with Continuous Hemofiltration and Fresh Frozen Plasma Transfusion without Plasma Exchange
HAYAKAWA Mineji, GANDO Satoshi, HOSHINO Hirokatsu, YAMAZAKI Kei, KAMEUE Takashi, MORIMOTO Yuji, MATSUBARA Izumi
Nihon Kyukyu Igakukai Zasshi, 14, 1, 16, 22, 日本救急医学会, 15 Jan. 2003
Japanese, 劇症肝不全は,Treyらによって定められた急激な肝細胞壊死による重度の肝機能障害を起こし,発症から8週以内に肝性脳症や凝固障害を中心とする肝不全症状を認めるきわめて予後不良な疾患である。国内ではウイルス性肝炎を原因とするものが多いため,Treyらの基準をもとにした同様の診断基準(犬山シンポジウムの診断基準)で劇症肝炎と称されている。劇症肝不全に対しても肝移植が可能な現況ではあるが,その治療の中心は人工肝補助療法artificial liver support (ALS)を中心とした内科的治療である。また肝移植を行う場合で も,bridge useとしてALSは重要な位置を占めている。現在までに,血漿交換plasma exchange(以下PEと略す)や持続的血液濾過透析,血液吸着など様々な血液浄化法がALSとして報告されているが,その評価は定まっていない。しかし,国内では間欠的もしくは持続 的なPEがALSの中心として考えられており,重症肝障害の内科的治療においてPEは欠くことのできないものとされている。われわれは劇症肝不全の治療にPEは必須ではないとの立場より,中分子領域の物質の除去が可能な持続的血液濾過continuous hemofiltration (CHF)を中心とした治療を行い,PEを行うことなく意識を改善させた3症例について,若干の文献的考察を加えて報告し,P... - A case of possibly azathioprine-induced interstitial pneumonia after renal transplantation
HAYAKAWA Mineji, GANDO Satoshi, KANO Hitoshi, YAMAZAKI Kei, SATOU Tomoyuki, KAMEUE Takashi, MORIMOTO Yuji, MATSUBARA Izumi
日本集中治療医学会雑誌 = Journal of the Japanese Society of Intensive Care Medicine, 10, 1, 29, 32, 日本集中治療医学会, 01 Jan. 2003
Japanese, 腎移植後の免疫抑制薬投与中のcornpromised hostに発生したアザチオプリン(azathioprine,AZ)によると考えられる間質性肺炎を経験した。患者は腎移植後であり,AZなどの免疫抑制薬を投与されていた。移植から9ヵ月経過した頃より,発熱と咳嗽が出現し,その1週間後に当院入院となった。胸部CTなどで軽度の間質性肺炎を認めた。日和見感染による間質性肺炎を疑い,各種感染症に対する治療も開始したが反応せず,入院から4週後に死亡した。AZの総投与量は15,750mgであった。剖検にて,肺は間質性肺炎の像を示していたが感染を示唆する所見はなかった。原因は確定できなかったが,AZが最も疑われた。AZの投与を受けている患者はcompromised hostであり,日和見感染による間質性肺炎にも注意が必要であるが,AZによる間質性肺炎も鑑別疾患の一つとして重要である。 - Changes in cerebral oxygenation in children undergoing surgical repair of ventricular septal defects
Y Morimoto, Y Niida, K Hisano, Y Hua, O Kemmotsu, T Murashita, K Yasuda
ANAESTHESIA, 58, 1, 77, 83, Jan. 2003
English, Scientific journal - Chnages in Cerebral Oxygenation State and Blood Volume During Tracheal Intubation : Comparison Between Thiamylal and Propofol
MORIMOTO Yuji, KEMMOTSU Osamu, HISANO Kenjiro, HUA Yu, TANG Sijian, MORIMOTO Yoshiko
Circulatory Control, 24, 2, 124, 130, 2003
English - Effect of acidosis on apoptosis and necrosis induced by hypoxia in neuronal PC 12 cells.
Circulatory Control, 24, 1, 53, 57, 2003 - Effects of epinephrine and phosphodiesterase III inhibitors on bupivacaine-induced myocardial depression in guinea-pig papillary muscle
M Azuma, M Yamane, K Tachibana, Y Morimoto, O Kemmotsu
BRITISH JOURNAL OF ANAESTHESIA, 90, 1, 66, 71, Jan. 2003, [Peer-reviewed]
English, Scientific journal - The roles of nociceptin/orphanin FQ and nociceptin/orphanin FQ peptide (NOP) receptor in respiratory rhythm generation in the medulla oblongata： an in vitro study.
Takita K, Morimoto Y, Kemmotsu O
British Journal of Anaesthesia, 91, 385, 389, 2003, [Peer-reviewed]
English, Scientific journal - Imbalances between the levels of tissue factor and tissue factor pathway inhibitor in ARDS patients
S Gando, T Kameue, N Matsuda, M Hayakawa, Y Morimoto, T Ishitani, O Kemmotsu
THROMBOSIS RESEARCH, 109, 2-3, 119, 124, Jan. 2003, [Peer-reviewed]
English, Scientific journal - Satisfactory recovery of consciousness after prolonged cardiopulmonary resuscitation due to unexpected hemorrhage during a conduit ileum examination
Mariko Haga, Katsumi Harasawa, Yuji Morimoto, Osamu Kemmotsu
Journal of Anesthesia, 17, 3, 190, 192, 3, 2003, [Peer-reviewed]
English, Scientific journal - Combined Spinal-Epidural Anesthesia for Cesarean Section in a Patient with Dilated Cardiomyopathy
HISANO Kenjiro, AOKI Gota, YU Hua, MORIMOTO Yuji, KEMMOTSU Osamu
循環制御 = CIRCULATION CONTROL, 23, 4, 441, 444, 20 Dec. 2002
Japanese - The Hypoglossal Nerve and Recurrent Nerve Palsy After Mitral Valve Plasty ; Is insertion of a Transesophageal Echocardiography Probe Insertion a Cause?
TACHIBANA Kaori, HISANO Kenjiro, KOBAYASHI Shigeaki, MORIMOTO Yuji, KEMMOTSU Osamu
循環制御 = CIRCULATION CONTROL, 23, 4, 449, 451, 20 Dec. 2002
Japanese - Combined activation of coagulation and inflammation has an important role in multiple organ dysfunction and poor outcome after severe trauma
S Gando, T Kameue, N Matsuda, M Hayakawa, T Ishitani, Y Morimoto, O Kemmotsu
THROMBOSIS AND HAEMOSTASIS, 88, 6, 943, 949, Dec. 2002, [Peer-reviewed]
English, Scientific journal - Abdominal compartment syndrome and intrahepatic portal venous gas: a possible complication of endoscopy
M Hayakawa, S Gando, T Kameue, Y Morimoto, O Kemmotsu
INTENSIVE CARE MEDICINE, 28, 11, 1680, 1681, Nov. 2002, [Peer-reviewed]
English - Effects of mild and moderate hypothermia on apoptosis in neuronal PC12 cells
T Shibano, Y Morimoto, O Kemmotsu, H Shikama, K Hisano, Y Hua
BRITISH JOURNAL OF ANAESTHESIA, 89, 2, 301, 305, Aug. 2002
English, Scientific journal - Sevoflurane metabolite production in a small cohort of coronary artery bypass graft surgery patients
H Sakamoto, T Mayumi, Y Morimoto, O Kemmotsu, H Wakisaka, T Ohno
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 16, 4, 463, 467, Aug. 2002, [Peer-reviewed]
English, Scientific journal - Tissue factor production not balanced by tissue factor pathway inhibitor in sepsis promotes poor prognosis
S Gando, T Kameue, Y Morimoto, N Matsuda, M Hayakawa, O Kemmotsu
CRITICAL CARE MEDICINE, 30, 8, 1729, 1734, Aug. 2002, [Peer-reviewed]
English, Scientific journal - Ventricular fibrillation after pseudo-Bartter's syndrome
M Hayakawa, S Sugimoto, Matsubara, I
ANNALS OF EMERGENCY MEDICINE, 39, 2, 205, 206, Feb. 2002, [Peer-reviewed]
English - Pharmacokinetics of Tacrolimus and Fluconazole in Liver Transplant Recipients during Continuous Hemodiafiltration.
KOSHINAMI YUKA, HOSOI TAKERU, TAKEKUMA YO, KOBAYASHI MICHIYA, MORIMOTO YUJI, GANDO SATOSHI, FURUKAWA HIROYUKI, TODO SATORU, MIYAZAKI KATSUMI
TDM研究, 19, 1, 39, 43, (一社)日本TDM学会, Jan. 2002, [Peer-reviewed]
Japanese, Scientific journal - Systematic elucidation of effects of tranexamic acid on fibrinolysis and bleeding during and after cardiopulmonary bypass surgery
T Kojima, S Gando, Y Morimoto, H Mashio, Y Goda, H Kawahigashi, O Kemmotsu
THROMBOSIS RESEARCH, 104, 5, 301, 307, Dec. 2001, [Peer-reviewed]
English, Scientific journal - Hungry Bone Syndrome, Psychosis, and Cardiac Arrest During Antihyperthyroid Therapy
HAYAKAWA Mineji, GANDO Satoshi, MORIMOTO Yuji, NOZAKI Kouji, NAKAMURA Kouji, FURUNE Takashi, MATSUBARA Izumi
Nihon Kyukyu Igakukai Zasshi, 12, 7, 372, 376, Japanese Association for Acute Medicine, 15 Jul. 2001
Japanese, Several symptoms following acute suppression of thyroid function during antihyperthyroid therapy remain yet to be uniformly recognized. We present a case manifesting electrolyte disorder, psychosis, and cardiac arrest during antihyperthyroid therapy. A 46-year-old woman diagnosed with hyperthyroidism and treated with propylthiouracil and β-blocker for a month was admitted to another hospital reporting dyspnea. A few hours after admission, she suddenly underwent cardiac arrest. After immediate cardiopulmonary resuscitation, severe hypocalcemia and cardiomegaly were diagnosed. She was transferred to our emergency room due to her obscure clinical course and severe hypocalcemia. She also experienced hallucinations. Electrocardiography, echocardiography, and chest radiography showed no abnormalities. Calcium administration gradually lowered her serum calcium to within normal range on day 5 after admission. Her mental disturbance disappeared and thyroid function returned to normal. Her severe electrolyte disorder also improved after treatment. She was discharged from the hospital in good condition. Hypocalcemia following acute suppression of thyroid function has been recently recognized as "hungry bone syndrome." Different psychiatric symptoms and cardiocirculatory disturbances are observed during antihyperthyroid treatment. As our case showes, the importance of intensive care for patients with hyperthyroidism cannot be overemphasized. - Macrophage migration inhibitory factor is a critical mediator of systemic inflammatory response syndrome
S Gando, J Nishihira, S Kobayashi, Y Morimoto, S Nanzaki, O Kemmotsu
INTENSIVE CARE MEDICINE, 27, 7, 1187, 1193, Jul. 2001, [Peer-reviewed]
English, Scientific journal - Postoperative myocardial ischemia in thoracic aortic aneurysms
S Sasaki, K Yasuda, S Nanzaki, S Kobayashi, Y Morimoto, S Gando, O Kemmotsu
JOURNAL OF CARDIOVASCULAR SURGERY, 42, 3, 333, 338, Jun. 2001, [Peer-reviewed]
English, Scientific journal - Cholinergic Crisis Induced by a Usual Dose of Distigmine Bromide
HAYAKAWA Mineji, GANDO Satoshi, MORIMOTO Yuji, TAKEYAMA Yoshihiro, NAKAMURA Kouji, FURUNE Takashi, MATSUBARA Izumi
Nihon Kyukyu Igakukai Zasshi, 12, 5, 256, 260, Japanese Association for Acute Medicine, 15 May 2001
Japanese, Distigmine bromide is an anticholinesterase used to treat urinary retention. We describe a case of life-threatening cholinergic crisis induced by a usual oral dose of distigmine bromide for postoperative urinary retention. An 82-year-old man with mild chronic renal failure was transferred to our emergency room due to cholinergic crisis accompanied by cyanosis, hypotension, and consciousness disturbance. The patient was 10mg/day of distigmine bromide orally administered for 2 days. The patient's serum cholinesterase decreased to 3IU/l. Mechanical ventilation, fluid resuscitation, and inotropic support were started. A few days after admission, despite continuous low serum cholinesterase, his toxic symptoms almost disappeared. Extubation was done, and the patient had an event-free recovery. The possibility of cholinergic crisis should be considered when patients with renal failure are given distigmine bromide. During cholinergic crisis, toxic symptoms do not parallel serum cholinesterase. Cholinergic crisis should thus be treated while carefully observing clinical symptoms. - Preoperative explanation about postoperative care decreases patient's anxiety
MORIMOTO Yuji, AOYAMA Maki, SASAKI Shigeyuki, GANDO Satoshi, KENMOTSU Osamu
Journal of the Japanese Society of Intensive Care Medicine, 8, 2, 135, 136, The Japanese Society of Intensive Care Medicine, 01 Apr. 2001
Japanese - 生体肝移植患者における持続血液濾過透析(CHDF)施行時のタクロリムス及び抗真菌剤の血中動態
越浪 由加, 須田 範行, 武隈 洋, 小林 道也, 岸野 吏志, 森本 裕二, 丸藤 哲, 古川 裕之, 藤堂 省, 宮崎 勝巳
TDM研究, 18, 2, 169, 170, (一社)日本TDM学会, Apr. 2001
Japanese - Early Extubation in the Operating Room for Pediatric Minimally Invasive Cardiac Surgery
NIIDA Yukihiro, HARASAWA Katsumi, HASHIMOTO Toshikazu, MORIMOTO Yuji, KEMMOTSU Osamu
循環制御 = CIRCULATION CONTROL, 22, 1, 26, 28, 30 Mar. 2001
Japanese - Asymptomatic,Intraoperative Aortic Dissection Detected by Transesophageal Echocardiography (TEE) -A Case Report
TACHIBANA Kaori, KANDA Tomoe, HARASAWA Katsumi, MORIMOTO Yuji, KEMMOTSU Osamu
循環制御 = CIRCULATION CONTROL, 22, 1, 29, 31, 30 Mar. 2001
Japanese - Late-onset Bochdalek's Hernia Associated with Severe Dyspnea
HAYAKAWA Mineji, GANDO Satoshi, MORIMOTO Yuji, TAKEYAMA Yoshihiro, NAKAMURA Kouji, FURUNE Takashi, MATSUBARA Izumi
Nihon Kyukyu Igakukai Zasshi, 12, 2, 63, 66, Japanese Association for Acute Medicine, 15 Feb. 2001
Japanese, Late-onset Bochdalek's hernia is rare enough to be frequently diagnosed incorrectly. We present a case of lateonset Bochdalek's hernia associated with severe dyspnea and cyanosis. A 14-month-old female infant was admitted to our emergency clinic due to severe dyspnea and cyanosis. A chest radiogram and computed tomographic (CT) scan revealed a gastrointestinal shadow in the left thorax, necessitating emergency surgery that confirmed Bochdalek's hernia. Although left lung dysplasia was observed, we found no other malformation. A few days later, the endotracheal tube was extubated and the patient had an uneventful recovery. Symptoms, signs, and radiologic findings in patients with diaphragmatic hernia after the neonatal period are difficult to diagnose, and may result in misdiagnosis. Diaphragmatic hernia should thus be considered when examining infants suffering from severe dyspnea. - Tissue factor pathway inhibitor response does not correlate with tissue factor-induced disseminated intravascular coagulation and multiple organ dysfunction syndrome in trauma patients
S Gando, S Nanzaki, Y Morimoto, T Ishitani, O Kemmotsu
CRITICAL CARE MEDICINE, 29, 2, 262, 266, Feb. 2001, [Peer-reviewed]
English, Scientific journal - Significance of systemic inflammatory response syndrome after hepatectomy.
Circulatory Control, 22, 215, 219, 2001 - Do all patients with mandibular hypoplasia present difficulty in endotracheal intubation?
K. Takita, T. Minamimoto, Y. Morimoto, O. Kemmotsu
Japanese Journal of Anesthesiology, 50, 4, 387, 389, 2001, [Peer-reviewed]
Japanese, Scientific journal - Pathological evaluation of venous emboli during total hip arthroplasty
M. Hayakawa, Y. Fujioka, Y. Morimoto, A. Okamura, O. Kemmotsu
Anaesthesia, 56, 6, 571, 575, 2001, [Peer-reviewed]
English, Scientific journal - Systemic macrophage migration inhibitory factor release following hepatic resection
S Gando, J Nishihira, S Kobayashi, Y Morimoto, M Matsushita, O Kemmotsu
SURGERY TODAY, 31, 7, 605, 609, 2001, [Peer-reviewed]
English, Scientific journal - Serial measurement of arterial lactate concentrations as a prognostic indicator in relation to the incidence of disseminated intravascular coagulation in patients with systemic inflammatory response syndrome
S Kobayashi, S Gando, Y Morimoto, S Nanzaki, O Kemmotsu
SURGERY TODAY, 31, 10, 853, 859, 2001, [Peer-reviewed]
English, Scientific journal - Predictors of mortality in patients treated with continuous hemodiafiltration for acute renal failure in an intensive care setting
S Sasaki, S Gando, S Kobayashi, S Nanzaki, T Ushitani, Y Morimoto, O Demmotsu
ASAIO JOURNAL, 47, 1, 86, 91, Jan. 2001, [Peer-reviewed]
English, Scientific journal - Do age-based formulae predict the appropriate endotracheal tube sizes in Japanese children?
Takita K, Morimoto Y, Okamura A, Kemmotsu O
Journal of Aneshtesia, 15, 3, 145, 148, 2001, [Peer-reviewed]
English, Scientific journal - Increased sensitivity to vecuronium and prolonged duration of its action in patients with end-stage renal failure.
Sakamoto H, Takita K, Kemmotsu O, Morimoto Y, Mayumi T
Journal of Clinical Anesthesia, 13, 193, 197, 2001, [Peer-reviewed]
English, Scientific journal - Tracheal lidocaine attenuates the cardiovascular response to endotracheal intubation.
Takita K, Morimoto Y, Kemmotsu O
Canadian Journal of Anesthesia, 48, 732, 736, 2001, [Peer-reviewed]
English, Scientific journal - ハーモニックスカルペル®による気管内チューブ損傷
早川 峰司, 森本 裕二, 劔物 修
麻酔, 49, 11, 1261, 1262, Nov. 2000
Japanese, 超音波駆動メス(Harmonic Scalpel®, 以下HS, Johnson & Johnson Medical社, 東京)を用いた扁桃摘出術中に気管チューブの損傷を来し, 著しいカフ漏れを起こした症例を経験したので報告する. - Water Toxicity following Percutaneous Nephrolithotripsy
早川 峰司, 森本 裕二, 劔物 修
臨床麻酔, 24, 9, 1521, 1522, 真興交易, Sep. 2000
Japanese, A 61–year-old man underwent percutaneous nephrolithotripsy (PNL) for renal stone under general anesthesia. At fist, physiologic saline was used as irrigation fluid. This was changed to 3% sorbitol by an order of the urologist because the surgery would be prolonged. Total of 6L of physiologic saline and 15L of 3% sorbitol were used as irrigation fluid. After the surgery, the patient complained of nausea and severe hypotension was observed. Laboratory data showed severe anemia and hyponatremia indicating intraoperative bl... - 再拡張性肺水腫を合併した緊急帝王切開の周術期管理
早川 峰司, 森本 裕二, 劔物 修
麻酔, 49, 9, 1015, 1017, 克誠堂出版, Sep. 2000
Japanese, 妊娠後期に発見された大量胸水貯留に対しドレナージを施行後，再拡張性肺水腫を来し，さらに胎児心音の低下を認めたため緊急帝王切開となった症例を経験したので，報告する。 - Phosphodiesterase III inhibitor olprinone chlorate is not significantly removed by continuous venovenous hemodiafiltration
H Amenomori, S Sasaki, K Hiraoka, Y Morimoto, S Gando, O Kemmotsu
ASAIO JOURNAL, 46, 5, 635, 638, Sep. 2000, [Peer-reviewed]
English, Scientific journal - 直列式一回注入量3.0mlディスポーザブルPCA装置を用いた硬膜外鎮痛
掛端 仁, 渋谷 真希子, 横田 祥, 瀧川 千鶴子, 辻永 宏文, 蔦原 祥, 森本 裕二, 劔物 修
麻酔, 49, 8, 851, 856, 克誠堂出版(株), Aug. 2000
Japanese - パテントブルーによる偽性メトヘモグロビン血症
早川 峰司, 森本 裕二, 劔物 修
麻酔, 49, 7, 774, 776, Jul. 2000
Japanese, パテントブルーとニトログリセリンの同時使用下において，パルスオキシメ一群と血液ガス分析の異常値の評価に混乱を来し，メトヘモグロビン血症と誤判断した症例を経験した。 - Patent blue-induced false-methemoglobinemia
Mineji Hayakawa, Yuji Morimoto, Osamu Kemmotsu
Japanese Journal of Anesthesiology, 49, 7, 774, 776, Jul. 2000, [Peer-reviewed]
Japanese, Scientific journal - Efficacy of Transesophageal Echocardiography in the Evaluation of Cardiac Stab Wound
HAYAKAWA Mineji, OKAMURA Atsushi, MATSUDA Naoyuki, MORIMOTO Yuji, KEMMOTSU Osamu
循環制御 = CIRCULATION CONTROL, 21, 2, 205, 208, 日本循環制御医学会, 30 Jun. 2000
Japanese, 交通事故や自殺の増加，暴力事件の過激化などにより，胸部外傷の頻度は増加している．救急医療の現場で，これらの症例に遭遇する機会も増えていると思われる．この様な状況の中で，胸部外傷患者に対する診断と治療には種々の手段がある．今回，心臓に達していることが考えられる胸部刺創において，経食道心エコー図（以下TEE）が有用であった症例を経験したので報告する． - Hypercapnea after minitracheotomy
Naoyuki Matsuda, Takashi Nakamura, Yuji Morimoto, Osamu Kemmotsu
Japanese Journal of Anesthesiology, 49, 4, 428, 431, Apr. 2000, [Peer-reviewed]
Japanese, Scientific journal - The Effects of Epidural Block on Hemodynamic Responses to Emergence from General Anesthesia and Tracheal Extubation or Removal of Laryngeal Mask Airway
SHIMIZU Yasuyuki, KASENO Shigeo, MORIMOTO Yuji, SHIKAMA Hirochika, ISHIKAWA Takehiko, KEMMOTSU Osamu
循環制御 = CIRCULATION CONTROL, 21, 1, 28, 31, 31 Mar. 2000
Japanese - The Effects of Anesthetic Management on Arterial Oxygenation during One-lung Ventilation : Comparison between Propofol and Isoflurance
KOMURA Yoshihiro, KATO Manabu, MORIMOTO Yoshiko, MORIMOTO Yuji, KEMMOTSU Osamu
THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA, 20, 2, 97, 100, 15 Mar. 2000
Japanese - Delayed Upper Airway Obstruction Following a Retropharyngeal Hematoma
HAYAKAWA Mineji, GANDO Satoshi, MORIMOTO Yuji, KEMMOTSU Osamu
Nihon Kyukyu Igakukai Zasshi, 11, 3, 129, 133, 日本救急医学会, 10 Mar. 2000
Japanese, 後咽頭間隙血腫の報告はきわめてまれであり,国内においては数例の報告をみるに過ぎない。しかし,後咽頭間隙の解剖学的特徴から,同部位への血腫形成は気道を圧迫し呼吸困難や呼吸停止を来す可能性があるため的確な対応が必要な救急疾患のひとつである。今回,頭頸部の軽微な外傷により遅発性の後咽頭間隙血腫を来し,呼吸困難に陥った症例を経験したので文献的考察を加えて報告する。 - Perioperative management for emergency cesarean section of a patient with reexpansion pulmonary edema
M. Hayakawa, Y. Morimoto, O. Kemmotsu
Japanese Journal of Anesthesiology, 49, 9, 1015, 1017, 2000, [Peer-reviewed]
Japanese, Scientific journal - Tracheal tube damage by harmonic scalpel® during tonsillectomy
M. Hayakawa, Y. Morimoto, O. Kemmotsu
Japanese Journal of Anesthesiology, 49, 11, 1261, 1262, 2000, [Peer-reviewed]
Japanese, Scientific journal - Out-of-hospital cardiac arrest increases soluble vascular endothelial adhesion molecules and neutrophil elastase associated with endothelial injury
S Gando, S Nanzaki, Y Morimoto, S Kobayashi, O Kemmotsu
INTENSIVE CARE MEDICINE, 26, 1, 38, 44, Jan. 2000, [Peer-reviewed]
English, Scientific journal - Systemic activation of tissue-factor dependent coagulation pathway in evolving acute respiratory distress syndrome in patients with trauma and sepsis
S Gando, S Nanzaki, Y Morimoto, S Kobayashi, O Kemmotsu
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 47, 4, 719, 723, Oct. 1999, [Peer-reviewed]
English, Scientific journal - Tissue factor and tissue factor pathway inhibitor levels during and after cardiopulmonary resuscitation
S Gando, S Nanzaki, Y Morimoto, S Kobayashi, O Kemmotsu
THROMBOSIS RESEARCH, 96, 2, 107, 113, Oct. 1999, [Peer-reviewed]
English, Scientific journal - 脳虚血に対するペントバルビタール, ミダゾラムの保護効果の機序 : アポトーシス抑制の可能性
森本 裕二, 森本 佳子, 劔物 修, 柴野 岳樹, 四釜 裕睦
循環制御 = CIRCULATION CONTROL, 20, 3, 255, 258, 30 Sep. 1999
Japanese - Effects of Integrated OR Data Management System on Critical Anesthesia Management for Acute Cardiovascular Events during Surgery
ISHIKAWA Takehiko, KANDA Tomoe, OKAMURA Atsushi, MORIMOTO Yuji, KEMMOTSU OSAMU
循環制御 = CIRCULATION CONTROL, 20, 3, 299, 309, 30 Sep. 1999
Japanese - Alterations of soluble L- and P-selectins during cardiac arrest and CPR
S Gando, S Nanzaki, Y Morimoto, S Kobayashi, O Kemmotsu
INTENSIVE CARE MEDICINE, 25, 6, 588, 593, Jun. 1999, [Peer-reviewed]
English, Scientific journal - 近赤外分光法による脳内酸素飽和度測定
森本 裕二, 劔物 修
日本臨床麻酔学会誌 = The Journal of Japan Society for Clinical Anesthesia, 19, 4, 248, 251, 15 May 1999
Japanese - Ionized hypocalcemia during cardiac arrest and cardiopulmonary resuscitation
GANDO Satoshi, MORIMOTO Yuji, KEMMOTSU Osamu
Japanese Journal of Reanimatology, 18, 1, 15, 20, The Japanese Society of Reanimatology, 20 Apr. 1999
Japanese, Although calcium ions play a critical role in myocardial contractile performance and impulse formation, retrospective and prospective studies in the cardiac arrest setting have not demonstrated benefit from the use of calcium. In addtion, there is a considerable theoretical reason to believe that heigh levels induced by calcium administration may be detrimental. However, there have been few studies that investigated the variations of the levels of calcium during cardiac arrest. We recently demonstrated that ionized hypocalcemia occurs during out-of-hospital cardiac arrest and cardiopulmonary resuscitation (CPR) . The main mechanism of ionized hypocalcemia during CPR may be intracellular influx of ionized calcium due to ischemia and reperfusion. Complexing by bicarbonate is another mechanism. Although ionized calcium levels decrease during resuscitation from cardiac arrest, the mechanisms of ionized hypocalcemia and the detrimental effects of calcium administration suggest that calcium should not be employed during cardiac arrest and CPR except special situations, such as calcium channel blocker toxicity and hyperkalemia. - Comparison of Cerebral Regional Oxygen Saturation with Inhaled Anesthetics and Propofol-based Anesthesia during CABG Surgery with Cardiopulmonary Bypass
KINOSHITA Heijiro, SAKAMOTO Hiroshi, WAKISAKA Hiroshi, KANNDA Tomoe, MORIMOTO Yuji, MAYUMI Takahisa, KEMMOTSU Osamu
循環制御 = CIRCULATION CONTROL, 19, 4, 538, 541, 18 Dec. 1998
Japanese - Anesthesia for fourteen cases of auto-renal transplantation
Akira Inoue, Yuji Morimoto, Yoshihiro Ohta, Osamu Kemmotsu
Japanese Journal of Anesthesiology, 47, 10, 1221, 1225, Oct. 1998, [Peer-reviewed]
Japanese, Scientific journal - Effect of temperature on apoptosis in neuronal cells
Takaki Shibano, Yuji Morimoto, Osamu Kemmotsu
Critical Care Medicine, 26, 1, A81, Lippincott Williams and Wilkins, 1998
English, Scientific journal - Effect of pentobarbital and midazolam on apoptosis in neuronal cells
Yuji Morimoto, Yoshiko Morimoto, Osamu Kemmotsu, Takaki Shibano
Critical Care Medicine, 26, 1, A36, Lippincott Williams and Wilkins, 1998
English, Scientific journal - Cardiopulmonary Cerebral Resuscitation and Acidosis
Yuji Morimoto, Osamu Kemmotsu, Yoshiko Morimoto
Japanese Journal of Anesthesiology, 47, 7, 801, 805, 1998, [Peer-reviewed]
English, Scientific journal - Clinical Application of Automated Anesthesia Record Keeping System in Cardiovascular Anesthesia
OKAMURA Atsushi, MORIMOTO Yuji, SHIIYA Norihiko, SATO Naoki, OHTA Yoshihiro, MAYUMI Takahisa, KEMMOTSU Osamu
循環制御 = CIRCULATION CONTROL, 18, 4, 577, 582, 19 Dec. 1997
Japanese - トノメトリ法による動脈圧測定 : 較正カフの測定値に与える影響
岡村 篤, 原澤 克己, 太田 善博, 森本 裕二, 劔物 修
日本臨床生理学会雑誌 = Japanese journal of applied physiology, 27, 6, 369, 372, 01 Dec. 1997
Japanese - Successful use of propofol for anesthesia for plasty of eyelids in epidermolysis bullosa
Ryo Inoue, Shigeaki Kobayashi, Yuji Morimoto, Osamu Kemmotsu
Japanese Journal of Anesthesiology, 46, 12, 1590, 1593, Dec. 1997, [Peer-reviewed]
Japanese, Scientific journal - Monitoring of Gut Intramucosal pH during Hepatic Resection
KATO Toshihumi, KOMURA Yoshihiro, MORIMOTO Yuji, SATO Naoki, KEMMOTSU Osamu
日本手術医学会誌 = Journal of Japanese Association for Operating Room Technology, 16, 4, 595, 599, 30 Nov. 1995
Japanese - The Effect of General Anesthesia or Thoracic Epidural Anesthesia on the Gut Oxygenation : Is the Gut Oxygenation Impaired by Dopamine Infusion?
KATO Toshihumi, KOMURA Yoshihiro, MORIMOTO Yuji, MORIMOTO Yoshiko, OHTA Yoshihiro, KEMMOTSU Osamu
循環制御 = CIRCULATION CONTROL, 16, 3, 371, 376, 30 Sep. 1995
Japanese - Noninvasive, continuous blood pressure measurement by arterial tonometry during anesthesia in children.
Kemmotsu O, Ohno M, Takita K, Sugimoto H, Otsuka H, Morimoto Y, Mayumi T
Anesthesiology, 81, 1162, 1164, 1994, [Peer-reviewed]
English, Scientific journal - 虚血性脳侵襲に及ぼすアシドーシスの影響 -ラット海馬スライスにおける無酸素・無グルコースモデルを用いた解析-
北海道医学雑誌, 68, 5, 717, 727, 1993 - Hemodynamic effects of nicardipine-induced hypotension during enflurane/nitrous oxide anesthesia in man
Atsushi Okamura, Osamu Kemmotsu, Yuji Morimoto, Takeyasu Yamamura, Takehiko Ishikawa, Fusazo Nakata
Journal of Anesthesia, 6, 4, 401, 406, Oct. 1992, [Peer-reviewed]
English, Scientific journal - Low Power Laser Therapy for Chronic Pain
SATO Kenichi, KEMMOTSU Osamu, HARADA Koji, FURUMIDO Hitoshi, HANAOKA Yukari, OTUKA Hiroshi, MORIMOTO Yuji, KASENO Shigeo
THE JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE, 11, 4, 3, 9, Japan Society for Laser Surgery and Medicine, 1991
Japanese, We have been using low power laser therapy (LT) in 152 patients with chronic pain of different origins at our pain clinic in the past four years. The effect of LT was evaluated in two fashions: the immediate effect and the long term effect. The averaged effective ratio was 66.4% for the immediate effect. In the immediate effect, Very good were 36 cases (23.7%), good 65 cases (42.8%), no change 50 cases (32.9%) and worse a case (0.6%). The averaged effective ratio was 74.3% for the long term effect. In the long term effect, no pain were 21 cases (13.8%), light pain 92 cases (60.5%), no change 39 cases (25.7%) and worse was not observed. LT was particular effective in patients of postherpetic neuralgia (PHN). The total effective ratio were high about 90% for PHN. Complications attributable to LT included general fatigue, hot sensation of the irradiation areas and and temporally increased pain. However, no serious side-effects were obtained in this series of patients. In future, LT might become popular due to its simplicity and noninvasiveness. - International repatriationの問題点--ロサンゼルスまでの患者搬送経験を通して
森本 裕二
救急医学, 14, 3, p391, 393, へるす出版, Mar. 1990
Japanese - End-tidal carbon dioxide concentration during cardiopulmonary resuscitation(CPR). Is this effective as an indicator of CPR success?:Is this Effective as an Indicator of CPR Success?
Morimoto Yuji, Sumiya Toshiji, Gando Satoshi, Matsubara Izumi, Tedo Ichiro, Kemmotsu Osamu
Nihon Kyukyu Igakukai Zasshi, 1, 1, 19, 24, Japanese Association for Acute Medicine, 1990
Japanese, The end-tidal carbon dioxide concentration (ETCO2) has been demonstrated to be a useful indicator of effectiveness of external cardiac massage and restoration of spontaneous circulation (ROSC) in animal models. It hes also been reported that ETCO2 might be a prognostic indicator of success in CPR. In human models, however, consistent results have not been obtained concerning effectiveness as an indicator of success in CPR. Therefore, we prospectively measured ETCO2 in 50 patients in out-of-hospital cardiac arrests during CPR. Nineteen patients who were successfully resuscitated had higher average ETCO2 values one minute after the initiation of ETCO2 recording in the emergency care unit (first ETCO2) than did 31 non-resuscitated patients. However this result shows that ETCO2 is not specific enough to be an indicator of success in CPR, because values varied widely in both groups. In 16 non-cardiogenic patients (with cerebral or respiratory factors), the first ETCO2 of the 7 resuscitated patients was significantly higher than that of the 9 non-resuscitated patients. The first ETCO2 of all 7 resuscitated patients was higher than 0.8%, and patients with a first ETCO2 lower than 0.8% were not resuscitated. This indicates that ETCO2 may be an indicator of CPR success in non-cardiogenic patients. Our findings suggest that differences in etiology of cardiac arrest may be one of the reasons for controversy as to whether ETCO2 can be an indicator of CPR success. - NEUROLOGIC PROGNOSIS FOLLOWING OUT-OF-HOSPITAL CARDIAC-ARREST - EVALUATION BY AUDITORY BRAIN-STEM RESPONSES (ABR)
Y MORIMOTO, S GANDO, MATSUBARA, I, TEDO, I, O KEMMOTSU
INTENSIVE AND CRITICAL CARE MEDICINE, 885, 994, 994, 1990, [Peer-reviewed]
English, International conference proceedings - The effects of pre-operative administration of ranitidine on pH and volume of gastric juice.
YOKOTA Sho, MIZUSHIMA Masako, IMAI Makoto, MORIMOTO Yuji, KEMMOTSU Osamu
Jpn. J. Clin. Pharmacol. Ther., 19, 2, 417, 422, The Japanese Society of Clinical Pharmacology and Therapeutics, 1988
Japanese, Effects of pre-operative administration of ranitidine on pH and volume of gastric juicewere evaluated in 42 patients undergoing elective surgery under general anesthesia. Allpatients were randomly divided into two groups: placebo group (group P), and ranitidinegroup (group R).Patients in group P received placebo (lactose) and served as controls.Patients in group R received ranitidine 300 mg orally at 9: 00 p.m.on the day before surgeryand 50 mg iv immediately after induction of anesthesia (9: 15a.m.). The pH and volumeof gastric juice were measured during induction of anesthesia and every one hour duringsurgery in both groups by continuous sampling of gastric juice utilizing a low-pressuremethod. Plasma ranitidine levels were measured by high performance liquid chromatographyin 5 patients of group R and compared with those of oral administration alone in 6 patientsand of iv administration alone in 6 patients. The gastric pH just after induction of anesthesiawas lower than 2. 5 in 67% of group P and 4% of group R (P<0.05). The gastric volumeover 25ml was seen in 17% of group P and none of group R. There were significantelevations in gastric pH at induction and 1, 2, 3, 5, and 6 hr following induction ofanesthesia in group R compared with group P. The total volume of gastric juice during 4-5hr surgery were 20 ml in group R and 37 ml in group P respectively (P<0.05). Theplasma ranitidine levels 3 hr after iv administration were 186 ng/ml in group R and 128ng/ml in patients of iv administration group alone (P<0.05), and 78ng/ml in patients oforal administration group alone. It is essential to keep gastric pH over 2.5 and gastricvolume less than 25 ml in order to prevent aspiration pneumonitis during anesthesia.Therefore, our data indicate that pre-operative administration (oral plus intravenous) ofranitidine is sufficiently effective to prevent aspiration pneumonitis related to acidity and volume of gastric juice during anesthesia.
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(一社)日本集中治療医学会, Japanese - 老化促進マウスを用いた敗血症急性期の海馬神経炎症とミクログリア活性化の検討
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日本神経麻酔集中治療学会, Japanese - 陸空路ECMO搬送時のバックボード装着型架台の構築と搬送経験
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(一社)日本ペインクリニック学会, Japanese - A case of air transportation of respiratory failure patients under the extracorporeal membrane oxygenation
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(一社)日本ペインクリニック学会, Japanese - 術前からの不安の強い患者の腹腔鏡下手術後に遷延性術後痛を生じた1例
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(一社)日本ペインクリニック学会, Japanese - A case of reversible cerebral vasoconstriction syndrome complicated with infant neuroblastoma
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真興交易(株)医書出版部, Japanese - Perioperative Management of Cesarean Section with Severe Thrombocytopenia and Platelet Transfusion Refractoriness due to Myelodysplastic Syndrome: A Case Report
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真興交易(株)医書出版部, Japanese - 大動脈基部置換術および弓部大動脈全置換術における無輸血手術の1症例
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Japanese - 統合的ストレス応答の阻害は術後認知機能障害を防止する
内田 洋介, 斉藤 仁志, 干野 晃嗣, 打浪 有可, 森本 裕二, 日本神経麻酔集中治療学会プログラム・抄録集, 22回, 47, 47, Jun. 2018
日本神経麻酔集中治療学会, Japanese - The Effect of T-shape Stopcock Lock Techniques to Prevent Blood Sample Contamination Compared with Collecting Samples from Non-closed Arterial Line System
高島史樹, 水野谷和之, 森本裕二, 麻酔, 67, 2, 203‐207, 207, 10 Feb. 2018
克誠堂出版(株), Japanese - 無輸血自己弁温存大動脈基部置換術の1症例
新井田周宏, 森本裕二, 紙谷寛之, 大川陽史, 柳清洋佑, 井上聡巳, 臨床麻酔(真興交易), 42, 1, 29‐32, 20 Jan. 2018
Japanese - Cantrell症候群に合併した大動脈縮窄複合に対するNorwood手術の1例
坂井俊朗, 斉藤仁志, 森本裕二, Cardiovascular Anesthesia, 22, Suppl, 2018 - 難治性の高度肺胞出血の補助治療として肺血流制限を試みた救命例
糸洲佑介, 早坂怜, 斉藤仁志, 石川岳彦, 森本裕二, 日本集中治療医学会学術集会(Web), 45th, 2018 - 特発性腹腔内出血により出血性ショックに至った患者の超緊急帝王切開術の麻酔経験
安藤貴士, 斉藤仁志, 森本裕二, 日本臨床麻酔学会誌, 38, 6, 2018 - Efficacy of nebulized gentamicin in acute exacerbation of bronchiectasis: a case report
武田圭史, 土岐崇幸, 干野晃嗣, 斉藤仁志, 柳田雄一郎, 森本裕二, 日本集中治療医学会雑誌(Web), 25, 3, 2018 - B群連鎖球菌による壊死性筋膜炎を発症し,感染性心内膜炎を合併した,高度肥満患者の一例
早坂怜, 斉藤仁志, 石川岳彦, 森本裕二, 丸藤哲, 日本集中治療医学会学術集会(Web), 45th, 2018 - 小児心臓手術中に人工心肺回路が閉塞した1症例
久保康則, 干野晃嗣, 森敏洋, 森本裕二, 臨床麻酔(真興交易), 41, 12, 1677‐1679, 1679, 20 Dec. 2017
真興交易(株)医書出版部, Japanese - 常染色体優性多発嚢胞腎および肝嚢胞の痛みに対してオピオイド治療を開始した1例
藤井 知昭, 三浦 基嗣, 長谷 徹太郎, 敦賀 健吉, 森本 裕二, 日本ペインクリニック学会誌, 24, 4, 349, 352, Oct. 2017
(一社)日本ペインクリニック学会, Japanese - 経胎盤的抗不整脈投与療法中の母体の帝王切開においてクリアサイトを用いて管理をした1症例の麻酔経験
三上 仁衣奈, 打浪 有可, 田中 暢洋, 斉藤 仁志, 森本 裕二, 日本臨床麻酔学会誌, 37, 6, S291, S291, Oct. 2017
日本臨床麻酔学会, Japanese - 双胎間輸血症候群に対する胎児鏡下胎盤吻合血管レーザー凝固術の周術期管理についての検討
長谷川 栄, 打浪 有可, 斉藤 仁志, 田中 暢洋, 森本 裕二, 日本臨床麻酔学会誌, 37, 6, S296, S296, Oct. 2017
日本臨床麻酔学会, Japanese - 人工気胸併用腹臥位の食道癌手術においてEZブロッカーが有用だった症例
浜谷 絵里, 藤田 憲明, 土岐 崇幸, 森本 裕二, 日本臨床麻酔学会誌, 37, 6, S310, S310, Oct. 2017
日本臨床麻酔学会, Japanese - 左心低形成症候群を合併した食道閉鎖症患者の麻酔経験
糸洲 佑介, 田中 暢洋, 森本 裕二, Cardiovascular Anesthesia, 21, Suppl., 261, 261, Sep. 2017
(一社)日本心臓血管麻酔学会, Japanese - 小児心臓手術中に人工心肺回路が閉塞した1症例
久保 康則, 水野谷 和之, 干野 晃嗣, 森 敏洋, 森本 裕二, Cardiovascular Anesthesia, 22, Suppl., 287, 287, Sep. 2017
(一社)日本心臓血管麻酔学会, Japanese - 左室肥大や流出路狭窄がない患者の非弁膜症手術中に僧帽弁収縮期前方運動が生じた1症例
出村 理海, 干野 晃嗣, 森 敏洋, 水野谷 和之, 久保 康則, 森本 裕二, Cardiovascular Anesthesia, 22, Suppl., 360, 360, Sep. 2017
(一社)日本心臓血管麻酔学会, Japanese - 幼若期ストレスによるラットのうつ様行動に対するケタミンの効果とその神経基盤研究
相川 勝洋, 吉田 隆行, 大村 優, 泉 剛, 吉岡 充弘, 森本 裕二, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 39回・47回, 163, 163, Sep. 2017
日本生物学的精神医学会・日本神経精神薬理学会, Japanese - 第2種高気圧酸素治療装置における油圧ユニットの圧力計破損の経験
平子 竜大, 石川 正勝, 岡本 花織, 太田 稔, 長谷 徹太郎, 敦賀 健吉, 森本 裕二, 日本高気圧環境・潜水医学会雑誌, 52, Suppl., 50, 50, Sep. 2017
(一社)日本高気圧環境・潜水医学会, Japanese - 高気圧酸素治療における創部用ドレナージバック破損の経験
平子 竜大, 石川 勝清, 岡本 花織, 太田 稔, 長谷 徹太郎, 敦賀 健吉, 森本 裕二, 日本高気圧環境・潜水医学会雑誌, 52, Suppl., 51, 51, Sep. 2017
(一社)日本高気圧環境・潜水医学会, Japanese - 抜管後の喉頭痙攣への対処法について
干野 晃嗣, 森本 裕二, 楠本 篤弘, 臨床麻酔, 41, 8, 1137, 1141, Aug. 2017
真興交易(株)医書出版部, Japanese - 抗リン脂質抗体症候群を合併した帝王切開12症例の検討
田中 暢洋, 村上 仁志, 佐藤 美奈, 森本 裕二, 森川 守, 水上 尚典, 麻酔, 66, 8, 818, 823, Aug. 2017
克誠堂出版(株), Japanese - 気道管理 当院における乳児挿管困難症例の原因についての検討
打浪 有可, 藤田 憲明, 森本 裕二, 日本小児麻酔学会誌, 23, 1, 125, 125, Aug. 2017
日本小児麻酔学会, Japanese - 特殊疾患 小児陽子線治療に伴い、短期間に複数回の連続挿管を要した2症例の検討
藤田 憲明, 敦賀 健吉, 森本 裕二, 日本小児麻酔学会誌, 23, 1, 144, 144, Aug. 2017
日本小児麻酔学会, Japanese - 無輸血Modified Bentall手術5例の経験
新井田 周宏, 萩原 綾希子, 森本 裕二, 大川 陽史, 柳清 洋佑, 井上 聡巳, 臨床麻酔, 41, 7, 987, 990, Jul. 2017
真興交易(株)医書出版部, Japanese - くも膜下フェノールブロックによってメサドンを減量し在宅療養に移行できた1症例
敦賀 健吉, 長谷 徹太郎, 三浦 基嗣, 森本 裕二, 日本ペインクリニック学会誌, 24, 3, 172, 172, Jun. 2017
(一社)日本ペインクリニック学会, Japanese - 七物降下湯がアロディニアに有効であったCRPSの一例
藤井 知昭, 三浦 基嗣, 長谷 徹太郎, 敦賀 健吉, 森本 裕二, 日本ペインクリニック学会誌, 24, 3, 392, 392, Jun. 2017
(一社)日本ペインクリニック学会, Japanese - メサドン導入時の薬剤調整の検討
三浦 基嗣, 敦賀 健吉, 長谷 徹太郎, 森本 裕二, 日本ペインクリニック学会誌, 24, 1, 91, 91, Feb. 2017
(一社)日本ペインクリニック学会, Japanese - 多発性嚢胞腎及び肝嚢胞の痛みに対してオピオイド導入を行い自宅退院が可能となった1例
藤井 知昭, 三浦 基嗣, 長谷 徹太郎, 敦賀 健吉, 森本 裕二, 日本ペインクリニック学会誌, 24, 1, 92, 92, Feb. 2017
(一社)日本ペインクリニック学会, Japanese - 体外膜型酸素化装置を要した急性骨髄性白血病の寛解導入療法後肺炎に合併した輸血関連急性肺障害の一例
斉藤 仁志, 舘澤 亮大, 早坂 怜, 水野谷 和之, 石川 岳彦, 森本 裕二, 丸藤 哲, 日本集中治療医学会雑誌, 24, Suppl., DP30, 1, Feb. 2017
(一社)日本集中治療医学会, Japanese - 血友病A患者に対する脳死肝移植の経験
水野谷 和之, 藤好 直, 石川 岳彦, 森本 裕二, 丸藤 哲, 日本集中治療医学会雑誌, 24, Suppl., DP76, 1, Feb. 2017
(一社)日本集中治療医学会, Japanese - ミノサイクリンは敗血症マウス海馬のシナプス可塑性低下を抑止する
干野 晃嗣, 森本 裕二, 日本集中治療医学会雑誌, 24, Suppl., O34, 1, Feb. 2017
(一社)日本集中治療医学会, Japanese - 前額部に貼付した体温測定プローブの干渉により脳波エントロピーが異常高値を示した1症例
水野谷 和之, 横山 健, 片山 勝之, 森本 裕二, 麻酔, 65, 12, 1279, 1281, Dec. 2016
克誠堂出版(株), Japanese - 気管内挿管下全身麻酔管理で陽子線治療を実施した小児がんの2症例(Proton beam therapy for pediatric cancer with endotracheal intubation under the general anesthesia: A report of two cases)
橋本 孝之, 敦賀 健吉, 小林 浩之, 井口 晶裕, 本多 昌平, 杉山 未奈子, 安田 耕一, 宮城 久之, 山口 秀, 藤田 憲明, 大島 淳二郎, 長 祐子, 鬼丸 力也, 清水 伸一, 寺坂 俊介, 森本 裕二, 白土 博樹, 日本小児血液・がん学会雑誌, 53, 4, 366, 366, Nov. 2016
(一社)日本小児血液・がん学会, English - 当院での小児鎖肛手術におけるアセトアミノフェン静注薬の使用と周術期管理への影響についての検討
田中 暢洋, 森本 裕二, 日本臨床麻酔学会誌, 36, 6, S289, S289, Oct. 2016
日本臨床麻酔学会, Japanese - 抜管一ヵ月後に再挿管を要する急激な喉頭炎と両側声帯麻痺を発症した頭部外傷患者の一例
相川 勝洋, 森本 裕二, 日本臨床麻酔学会誌, 36, 6, S348, S348, Oct. 2016
日本臨床麻酔学会, Japanese - 無輸血Bentall手術4例の経験
新井田 周宏, 萩原 綾希子, 森本 裕二, Cardiovascular Anesthesia, 20, Suppl., 231, 231, Sep. 2016
(一社)日本心臓血管麻酔学会, Japanese - 小児心臓手術における術後循環作動薬投与量と短期予後との関係
山本 真崇, 森 敏洋, 森本 裕二, Cardiovascular Anesthesia, 20, Suppl., 268, 268, Sep. 2016
(一社)日本心臓血管麻酔学会, Japanese - 第2種高気圧酸素治療装置における油圧ユニットの圧力計破損の経験
平子 竜大, 石川 勝清, 岡本 花織, 佐々木 亮, 松本 剛直, 前野 幹, 千葉 裕基, 村田 裕宣, 太田 稔, 森本 裕二, 敦賀 健吉, 長谷 徹太郎, 日本高気圧環境・潜水医学会雑誌, 51, 3, 176, 176, Sep. 2016
(一社)日本高気圧環境・潜水医学会, Japanese - 子どものエキスパートに聞く 麻酔はヒトの小児の神経発達に本当に悪影響を及ぼすか?
森本 裕二, 日本小児麻酔学会誌, 22, 1, 55, 55, Sep. 2016
日本小児麻酔学会, Japanese - 亜酸化窒素はNMDA受容体阻害作用により新生仔ラット海馬歯状回における新生顆粒細胞の移動を阻害する
斉藤 仁志, 森本 裕二, 日本神経麻酔集中治療学会プログラム・抄録集, 20回, 30, 30, Jul. 2016
日本神経麻酔集中治療学会, Japanese - 脊柱側彎症手術における運動誘発電位低下症例の検討
藤田 憲明, 森本 裕二, 市川 智大, 村上 望, 澁谷 斉, 加畑 馨, 清水 力, 日本神経麻酔集中治療学会プログラム・抄録集, 20回, 35, 35, Jul. 2016
日本神経麻酔集中治療学会, Japanese - 胸腹部大動脈瘤手術におけるプロポフォール投与量に関する検討
斉藤 仁志, 森 敏洋, 森本 裕二, 日本神経麻酔集中治療学会プログラム・抄録集, 20回, 41, 41, Jul. 2016
日本神経麻酔集中治療学会, Japanese - 高度の頸動脈狭窄にIABPが有用であった心臓手術の1症例
新井田 周宏, 森本 裕二, 日本神経麻酔集中治療学会プログラム・抄録集, 20回, 54, 54, Jul. 2016
日本神経麻酔集中治療学会, Japanese - 強度難治性のがん性痛に対して多剤併用で終末期の緩和ケアを行った1症例
敦賀 健吉, 田巻 知宏, 森本 裕二, 日本ペインクリニック学会誌, 23, 1, 77, 77, Feb. 2016
(一社)日本ペインクリニック学会, Japanese - フォンタン型手術時の乳酸値と短期予後との関係
山本 真崇, 八木 泰憲, 斉藤 仁志, 森 敏洋, 森本 裕二, 日本集中治療医学会雑誌, 23, Suppl., 447, 447, Jan. 2016
(一社)日本集中治療医学会, Japanese - Saccharomyces cereviciaeによる真菌敗血症の1例
斉藤 仁志, 森本 裕二, 日本集中治療医学会雑誌, 23, Suppl., 670, 670, Jan. 2016
(一社)日本集中治療医学会, Japanese - The efficacy of endobronchial embolization with silicone spigots: a case of intractable pneumothorax with acquired immunodeficiency syndrome
斉藤仁志, 品川尚文, 石川岳彦, 丸藤哲, 森本裕二, 日本集中治療医学会雑誌(Web), 22, 5, 2015 - 超音波内視鏡下吸引穿刺生検術後に血胸を来した1例
斉藤 仁志, 石川 岳彦, 丸藤 哲, 森本 裕二, 日本集中治療医学会雑誌, 22, Suppl., [DP106, 5], Jan. 2015
(一社)日本集中治療医学会, Japanese - 産科異常妊娠の麻酔 (特集 産科と麻酔 : 帝王切開と無痛分娩の麻酔法) -- (帝王切開麻酔の実際と留意点)
加藤 亮子, 森本 裕二, 産婦人科の実際, 63, 8, 1073, 1077, Aug. 2014
金原出版, Japanese - NEONATAL EXPOSURE TO NITROUS OXIDE DISTURBS GRANULE CELL MIGRATION IN THE RAT DENTATE GYRUS
H. Saito, R. Kato, T. Hashimoto, Y. Uchida, T. Hase, K. Takita, Y. Morimoto, ANESTHESIA AND ANALGESIA, 118, S174, S174, May 2014
English, Summary international conference - Neonatal Anesthesia Causes Long-term Disturbances of Hippocampal Synaptic Plasticity
KATO Rui, TACHIBANA Kaori, UCHIDA Yosuke, HASHIMOTO Toshikazu, TAKITA Koichi, MORIMOTO Yuji, JJSCA, 34, 1, 18, 24, 2014
Recent studies have pointed out that exposure of neonates to anesthetic agents causes acute widespread neurodegeneration and long-lasting neurocognitive dysfunction in rodents. Although acute toxic effects of sevoflurane on cellular viability in the hippocampus have been reported in some studies, little is known about the effects of neonatal anesthesia on long-term hippocampal synaptic plasticity, which has been implicated in the processes of neurocognitive function. We examine the long-term influences of neonatal exposure of pentobarbital, propofol, and sevoflurane on hippocampal synaptic plasticity in rats by using electrophysiological methods. Our data revealed that these agents cause suppression of long-term potentiation (LTP) induction in hippocampal CA1 region lasting into the post-growth period. This persistent change in synaptic plasticity after neonatal anesthesia may be one of the mechanisms underlying anesthetics-induced neurocognitive dysfunctions., THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA, Japanese - General Anesthetics Are Really Harmful to the Human Brain?
森本 裕二, 橘 かおり, 加藤 類, 麻酔, 62, S11, 20, Nov. 2013
克誠堂出版, Japanese - 医学部における高気圧酸素治療に関する教育についての検討
橋本聡一, 長谷徹太郎, 内田洋介, 加藤類, 敦賀健吉, 森本裕二, 日本高気圧環境・潜水医学会雑誌, 47, Supplement, 38, 30 Sep. 2012
Japanese - 難治性疼痛に対する強オピオイドとトラマドール配合錠の効果比較
敦賀健吉, 長谷徹太郎, 内田洋介, 加藤類, 橋本聡一, 森本裕二, 日本ペインクリニック学会誌, 19, 3, 328, 25 Jun. 2012
Japanese - 高気圧酸素治療における臨床高気圧酸素治療技師によるプリセプター制度の検討
石川勝清, 遠田麻美, 岡本花織, 竹内千尋, 佐々木亮, 前野幹, 太田稔, 敦賀健吉, 加藤類, 伊藤亮子, 橋本聡一, 森本裕二, 日本高気圧環境・潜水医学会雑誌, 46, 4, 253, 31 Dec. 2011
Japanese - Sevoflurane do not induce cardioprotection in patients undergoing off-pump coronary artery bypass surgery
H. Sakamoto, K. Harasawa, Y. Morimoto, H. Wakisaka, EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 27, 1, 73, 74, Jun. 2010
English, Summary international conference - 1秒量が1lを下回る患者に対する全身麻酔-過去5年間の症例検討も交えて-
斉藤仁志, 秦琢磨, 森本裕二, 麻酔, 57, 6, 2008 - Isoflurane bidirectionally modulates the hippocampal paired-pulse responses in vivo
Kaori Tachibana, Yuji Morimoto, NEUROSCIENCE RESEARCH, 58, S191, S191, 2007
English, Summary international conference - 脊髄損傷合併妊娠・分娩管理の1例
森川 守, 山田 秀人, 平山 恵美, 山田 俊, 島田 茂樹, 片岡 宙門, 長 和俊, 森本 裕二, 櫻木 範明, 水上 尚典, 北海道産科婦人科学会会誌, 50, 1, 95, 95, Jun. 2006
北海道産科婦人科学会, Japanese - メチルマロン酸血症の小児に対する生体部分肝移植における麻酔管理
敦賀健吉, 真弓享久, 森本裕二, 藤堂省, 窪田満, Journal of Anesthesia, 20, Supplement (CD-ROM), 2006 - 一過性脳虚血-再灌流障害に対する人工酸素運搬体(TRM645)の効果
掛端仁, 山口拓, 富樫広子, 森本裕二, 吉岡充弘, Journal of Anesthesia, 20, Supplement (CD-ROM), 2006 - Electrophysiological and neurochemical characterization of milnacipran on the rat serotonergic and noradrenergic systems
Kaori Tachibana, Machiko Matsumoto, Mitsuhiro Yoshioka, Yuji Morimoto, JOURNAL OF PHARMACOLOGICAL SCIENCES, 101, 115, 115, 2006
English, Summary international conference - A free radical scavenger, edaravone (MCI-186) protects nearly pure neuronal culture against hypoxic and glutamate insult.
K Hisano, Y Morimoto, Y Hua, N Kimura, CRITICAL CARE MEDICINE, 33, 12, A101, A101, Dec. 2005
English, Summary international conference - 脊髄損傷合併妊娠・分娩管理の1例
森川 守, 山田 秀人, 平山 恵美, 山田 俊, 島田 茂樹, 片岡 宙門, 長 和俊, 森本 裕二, 櫻木 範明, 水上 尚典, 日本産科婦人科学会東北連合地方部会誌, 53, 69, 69, Nov. 2005
日本産科婦人科学会-東北連合地方部会, Japanese - Circulating endotoxin and (1→3)-β-D-glucan levels during cardiopulmonary bypass and living donor orthotopic liver transplantation : clinical and experimental investigations
GANDO Satoshi, ISHITANI Toshiteru, KOJIMA Taku, ITO Keiko, SAKURAYA Fumika, MORIMOTO Yuji, Journal of the Japanese Society of Intensive Care Medicine, 12, 4, 387, 393, 01 Oct. 2005
Japanese - 脊髄損傷合併妊娠の1例
森川 守, 山田 秀人, 平山 恵美, 片岡 宙門, 島田 茂樹, 渡利 道子, 山田 俊, 長 和俊, 森本 裕二, 水上 尚典, 周産期医学, 35, 3, 427, 430, Mar. 2005
(株)東京医学社, Japanese - 多発性筋炎を合併した長期臥床患者の麻酔経験
越後谷 雄一, 佐藤 泰征, 松浦 弘司, 安達 昭, 森本 裕二, 臨床麻酔, 29, 3, 617, 618, Mar. 2005
真興交易(株)医書出版部, Japanese - プロポフォールの一過性脳虚血障害に対する影響
掛端仁, 富樫広子, 吉岡充弘, 森本裕二, Journal of Anesthesia, 19, Supplement (CD-ROM), 2005 - 神経因性疼痛に対する酢酸フレカイニドの鎮痛効果の検討
武隈 洋, 山﨑浩二郎, 志賀弘康, 菅原 満, 宮崎勝巳, 小澤剛久, 柴田万里子, 橋本聡一, 森本裕二, 第6回抗不整脈薬TDM研究会（東京）, 2005 - デクスメデトミジン
中村高士, 加藤類, 関下純可, 佐藤大輔, 櫻谷文香, 唐思健, 桑原稔, 柴田万里子, 瀧田恒一, 橋本聡一, 森本裕二, 臨床麻酔, 29, 729, 733, 2005
Japanese, Introduction other - 麻酔薬に脳保護効果はあるか-プロポフォール, イソフルラン, セボフルランに関する5年間のレビュー-
森本裕二, 臨床麻酔, 7, 1159, 1174, 2004 - Effects of propofol on action potential and ionic currents in guinea pig cardiomyocytes
F Sakuraya, S Kobayashi, M Azuma, T Ishitani, N Matsuda, Y Morimoto, S Gando, J Kimura, Y Hattori, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 160P, 160P, 2004
English, Summary international conference - Regional differences in milnacipran-induced synaptic plasticity between prefrontal cortex and hippocampus
K Tachibana, M Matsumoto, K Tahara, H Togashi, Y Morimoto, M Yoshioka, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 92P, 92P, 2004
English, Summary international conference - 神経因性疼痛に対する酢酸フレカイニドの鎮痛効果とTDMの有用性
山﨑浩二郎, 武隈 洋, 志賀弘康, 菅原 満, 宮崎勝巳, 小澤剛久, 柴田万里子, 橋本聡一, 森本裕二, 第18回北海道TDM研究会 研究発表会（札幌）, 2004 - Cerebral oxygenation changes during pediatric surgeries for cyanotic cardiac diseases
K Hisano, Y Morimoto, INTENSIVE CARE MEDICINE, 29, S51, S51, Sep. 2003
English, Summary international conference - Effect of acidosis on apoptosis and necrosis induced by hypoxia in neuronal PC 12 cells.
Hirochika Shikama, Yuji Morimoto, Satoshi Watanabe, Takaki Shibano, Kenjiro Hisano, Yu Hua, Sijian Tang, Osamu Kemmotsu, Circulatory Control, 24, 1, 53, 57, 2003 - Changes in cerebral oxygenation and blood volume during tracheal intubation: Comparison between thiamylal and propofol.
Yuji Morimoto, Osamu Kemmotsu, Kenjiro Hisano, Yu Hua, Sijian Tang, Yoshiko Morimoto, Circulatory Control, 24, 2, 124, 130, 2003
English - Changes in cerebral oxygenation in children undergoing surgical repair of ventricular septal defects
Y Morimoto, Y Niida, K Hisano, Y Hua, O Kemmotsu, T Murashita, K Yasuda, ANAESTHESIA, 58, 1, 77, 83, Jan. 2003
English - Effects of mild and moderate hypothermia on apoptosis in neuronal PC12 cells
T Shibano, Y Morimoto, O Kemmotsu, H Shikama, K Hisano, Y Hua, BRITISH JOURNAL OF ANAESTHESIA, 89, 2, 301, 305, Aug. 2002
English - The Use of A Perioperative Patient Information System for Improved Point-of-care Data Management
OKAMURA Atsushi, MORIMOTO Yuji, HARASAWA Katsumi, SATO Naoki, KEMMOTSU Osamu, 循環制御 = CIRCULATION CONTROL, 23, 2, 164, 170, 28 Jun. 2002
English - Percutaneous Cardiopulmonary Support in the Last Decade
SASAKI Shigeyuki, ISHITANI Toshiteru, NANZAKI Satoshi, MORIMOTO Yuji, KEMMOTSU Osamu, GANDO Satoshi, YASUDA Keishu, 循環制御 = CIRCULATION CONTROL, 22, 2, 125, 131, 30 Jun. 2001
English - Significance of systemic inflammatory response syndrome after hepatectomy.
Circulatory Control, 22, 215, 219, 2001 - Tissue factor pathway inhibitor response does not correlate with tissue factor-induced DIC and MODS in trauma patients
S Gando, S Nanzaki, T Kameue, Y Morimoto, O Kemmotsu, CRITICAL CARE MEDICINE, 28, 12, A140, A140, Dec. 2000
English, Summary international conference - Hypokalemic coma with tetany following pseudo-Bartter syndrome
M Hayakawa, S Gando, Y Morimoto, Y Takeyama, T Sato, Matubara, I, INTENSIVE CARE MEDICINE, 26, 11, 1711, 1711, Nov. 2000
English, Report scientific journal - 輸液・輸血加温法および装置 (特集 アトラス ベッドサイド処置) -- (2 循環器系の手技)
森本 裕二, 丸藤 哲, 救急医学, 24, 10, 1216, 1219, Sep. 2000
へるす出版, Japanese - Effect of acidosis and antioxidants on neuronal cell death due to hypoxia
H Shikama, Y Morimoto, T Shibano, O Kemmotsu, ANESTHESIOLOGY, 93, 3A, U186, U186, Sep. 2000
English, Summary international conference - An Increase in Macrophage Migration Inhibitory Factor Release in Patients with Cardiopulmonary Bypass Surgery
GANDO SATOSHI, NISHIHIRA JUN, KEMMOTSU OSAMU, KOBAYASHI SHIGEAKI, MORIMOTO YUJI, MATSUI YOSHIRO, YASUDA KEISHU, Surgery Today, 30, 8, 689, 694, 01 Aug. 2000
English - The effect of calcium channel blockers on cerebral oxygenation during tracheal extubation
Y Morimoto, Y Morimoto, O Kemmotsu, S Gando, T Shibano, H Shikama, ANESTHESIA AND ANALGESIA, 91, 2, 347, 352, Aug. 2000
English - Development of severe diabetic keto-acidosis with shock after changing interferon-beta into interferon-alpha for chronic hepatitis C
M Hayakawa, S Gando, Y Morimoto, O Kemmotsu, INTENSIVE CARE MEDICINE, 26, 7, 1008, 1008, Jul. 2000
English, Report scientific journal - Pentobarbital inhibits apoptosis in neuronal cells
Y Morimoto, Y Morimoto, J Nishihira, O Kemmotsu, T Shibano, S Gando, H Shikama, CRITICAL CARE MEDICINE, 28, 6, 1899, 1904, Jun. 2000
English - End-tidal CO2 and Resuscitation
Current Opinion in Anaesthesiology, 12, 2, 173, 7, 1999 - 多臓器不全におけるDIC (特集 DIC--救急領域における位置づけ)
丸藤 哲, 南崎 哲史, 森本 裕二, 救急医学, 22, 11, 1671, 1678, Oct. 1998
へるす出版, Japanese - Effect of hypothermia on apoptosis in neuronal cells
T Shibano, Y Morimoto, O Kemmotsu, ANESTHESIOLOGY, 89, 3A, U708, U708, Sep. 1998
English, Summary international conference - Pathological evaluation of venous emboli during total hip arthroplasty
M Hayakawa, Y Fujioka, Y Morimoto, O Kemmotsu, ANESTHESIOLOGY, 89, 3A, U952, U952, Sep. 1998
English, Summary international conference - Automated Anesthesia Record Keeping by Engineering Work Station Four Years Experience
OKAMURA Atsushi, MORIMOTO Yuji, OHTA Yoshihiro, SATOH Naoki, KEMMOTSU Osamu, OHSAKI Yasuhiko, Circ. Cont., 19, 2, 246, 254, 30 Jun. 1998
English - Effects of NMDA receptor glycine recognition site antagonism on cerebral metabolic rate for glucose and cerebral blood flow in the conscious rat
Y Morimoto, B Wu, RD Bart, Y Morimoto, RD Pearlstein, DS Warner, BRAIN RESEARCH, 779, 1-2, 170, 176, Jan. 1998
English - High-dose fentanyl does not adversely affect outcome from forebrain ischemia in the rat
Y Morimoto, Y Morimoto, RD Bart, RD Pearlstein, F Dexter, DS Warner, JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY, 9, 4, 316, 323, Oct. 1997
English - Extracellular acidosis delays cell death against glucose-oxygen deprivation in neuroblastoma x glioma hybrid cells
Y Morimoto, Y Morimoto, O Kemmotsu, ES Alojado, CRITICAL CARE MEDICINE, 25, 5, 841, 847, May 1997
English - Mechanism of cellular swelling induced by extracellular lactic acidosis in neuroblastoma-glioma hybrid (NG108-15) cells
ES Alojado, Y Morimoto, Y Morimoto, O Kemmotsu, ANESTHESIA AND ANALGESIA, 83, 5, 1002, 1008, Nov. 1996
English - Extramyocardial acidosis impairs cardiac resuscitability in isolated, perfused, rat hearts
Y Morimoto, O Kemmotsu, Y Morimoto, CRITICAL CARE MEDICINE, 24, 10, 1719, 1723, Oct. 1996
English - Acute changes in intracranial pressure and pressure-volume index after forebrain ischemia in normoglycemic and hyperglycemic rats
Y Morimoto, Y Morimoto, DS Warner, RD Pearlstein, STROKE, 27, 8, 1405, 1409, Aug. 1996
English - 27.麻酔情報管理における高性能ワークステーション : 3年間の改良点と今後の展望 : 第71回日本医科器械学会大会予稿集
岡村 篤, 佐藤 直樹, 森本 裕二, 劔物 修, 医科器械学, 66, 4, 224, 224, 01 Apr. 1996
日本医療機器学会, Japanese - 自動麻酔記録システム : 3年間の実績と問題点の評価
岡村 篤, 森本 裕二, 松田 英彦, 劒物 修, 日本手術医学会誌 = Journal of Japanese Association for Operating Room Technology, 17, 1, 80, 81, 28 Feb. 1996
Japanese - EFFECT OF SINGLE OR COMBINED TREATMENT WITH DIURETICS OF THE LACTIC ACIDOSIS-INDUCED NEURONAL CELL SWELLING
ES ALOJADO, Y MORIMOTO, Y MORIMOTO, O KEMMOTSU, ANESTHESIOLOGY, 83, 3A, A719, A719, Sep. 1995
English, Summary international conference - 153. 内視鏡下手術用フィブリングルー・スプレーの使用経験
西部 俊哉, 佐藤 直樹, 森本 裕二, 椎谷 紀彦, 武田 直樹, 伊藤 美智子, 内野 純一, 道家 充, 大久保 哲之, 高橋 利幸, 奥芝 俊一, 本原 敏司, 加藤 紘之, 西部 正泰, 日本手術医学会誌 = Journal of Japanese Association for Operating Room Technology, 16, 3, 507, 509, 31 Aug. 1995
Japanese - 157.術後MRSA感染症の治療 : 整形外科手術例を中心に
武田 直樹, 佐藤 直樹, 椎谷 紀彦, 森本 裕二, 西部 俊哉, 伊藤 美智子, 内野 純一, 日本手術医学会誌 = Journal of Japanese Association for Operating Room Technology, 16, 3, 515, 516, 31 Aug. 1995
Japanese - 血液感染症の術前スクリーニング結果の動向とその意義
椎谷 紀彦, 武田 直樹, 西部 俊哉, 森本 裕二, 佐藤 直樹, 安田 慶秀, 日本手術医学会誌 = Journal of Japanese Association for Operating Room Technology, 16, 2, 318, 319, 31 May 1995
Japanese - Auditory brainstem responses after out-of-hospital cardiac arrest: Are they useful for outcome prediction?
Yuji Morimoto, Osamu Kemmotsu, Koichi Kitami, Izumi Matsubara, Ichiro Tedo, Journal of Anesthesia, 9, 1, 22, 26, Mar. 1995
Springer-Verlag, English - PHOSPHOLIPASE-C INHIBITOR, NEOMYCIN PROTECTS THE NEURONAL CELLS AGAINST AN ISCHEMIC INSULT
Y MORIMOTO, Y MORIMOTO, O KEMMOTSU, ANESTHESIOLOGY, 81, 3A, A826, A826, Sep. 1994
English, Summary international conference - Crossover effects of acidosis on the recovery of neuronal function following glucose-oxygen deprivation in rat hippocampal slices
Yuji Morimoto, Takeyasu Yamamura, Osamu Kemmotsu, Journal of Anesthesia, 8, 3, 334, 338, Sep. 1994
Springer-Verlag, English - EFFECT OF LACTIC AND CO2 ACIDOSIS ON NEURONAL FUNCTION FOLLOWING GLUCOSE OXYGEN DEPRIVATION IN RAT HIPPOCAMPAL SLICES
Y MORIMOTO, O KEMMOTSU, Y MORIMOTO, BRAIN RESEARCH, 654, 2, 273, 278, Aug. 1994
English - END-TIDAL CO2 CHANGES UNDER CONSTANT CARDIAC-OUTPUT DURING CARDIOPULMONARY-RESUSCITATION
Y MORIMOTO, O KEMMOTSU, F MURAKAMI, T YAMAMURA, T MAYUMI, CRITICAL CARE MEDICINE, 21, 10, 1572, 1576, Oct. 1993
English - EFFECTS OF LACTIC AND CO2 ACIDOSIS ON OXYGEN-GLUCOSE DEPRIVATION IN THE RAT HIPPOCAMPAL SLICES
Y MORIMOTO, T YAMAMURA, O KEMMOTSU, ANESTHESIOLOGY, 79, 3A, A743, A743, Sep. 1993
English, Summary international conference - INFLUENCE OF HYPOXIC AND HYPERCAPNIC ACIDOSIS ON BRAIN WATER-CONTENT AFTER FOREBRAIN ISCHEMIA IN THE RAT
Y MORIMOTO, T YAMAMURA, O KEMMOTSU, CRITICAL CARE MEDICINE, 21, 6, 907, 913, Jun. 1993
English - ACUTE BRAIN-SWELLING AFTER OUT-OF-HOSPITAL CARDIAC-ARREST - PATHOGENESIS AND OUTCOME
Y MORIMOTO, O KEMMOTSU, K KITAMI, MATSUBARA, I, TEDO, I, CRITICAL CARE MEDICINE, 21, 1, 104, 110, Jan. 1993
English - Fickの原理による連続的血行動態解析
大塚 浩司, 山村 剛康, 佐藤 賢一, 古御堂 均, 森本 裕二, 劔物 修, 救急医学, 3月臨時増刊号, S, 270, Mar. 1990
(株)へるす出版, Japanese - 重度低酸素性乳酸アシドーシスに対するNaHCO3とDCAの比較検討
森本 裕二, 村上 富裕美, 仲田 房蔵, 中野 達, 水嶋 雅子, 山村 剛康, 櫻谷 憲彦, 劔物 修, 救急医学, 3月臨時増刊号, S, 415, Mar. 1990
(株)へるす出版, Japanese - Fickの原理のよる連続的血行動態解析
大塚 浩司, 山村 剛康, 佐藤 賢一, 古御堂 均, 森本 裕二, 劔持 修, 救急医学, 10月臨時増刊号, S, 733, Oct. 1989
(株)へるす出版, Japanese
Books and other publications
Affiliated academic society
Research Themes
- 統合的ストレス応答が敗血症関連脳障害に果たす役割の解明
科学研究費助成事業
01 Apr. 2021 - 31 Mar. 2025
森本 裕二, 内田 洋介, 干野 晃嗣
我々の目的は、敗血症モデルマウスを用いて敗血症性脳症(SAE)における統合的ストレス応答(ISR)の関与、ISRを制御する薬剤であるISRIBの効果について検討することである。
初年度は、敗血症マウスのモデル作成の手技の確立と、認知機能低下の検出を行うこととした。敗血症モデルマウスは盲腸結紮穿刺（CLP）を行い、その重症度は盲腸の結紮箇所と盲腸の穿通の太さ、回数等で調整した。
盲腸端から1.2cmを結紮し、21G針で２回穿刺、術後抗生剤投与を行ったモデルで１週間後の生存率は85%程度となり、このモデルを採用することとした。CLP後の体重推移、活動性について調査した。CLP群では、術後３日程度体重減少が続き、そこからは緩やかに体重が増加した。術後１週間後でのopen fieldでは、ラインクロス回数、Rearing(立ち上がり)、Grooming(毛繕い)のいずれもCLP群で有意に低下しており、明らかに活動性の低下が認められた。術後２週間時点のopen field では、ラインクロス回数、Rearing(立ち上がり)、Grooming(毛繕い)についてsham群とCLP群の差は有意でなく、活動性が回復したものと考えられた。
CLP後２週間時点で、Trace Fear conditioningを行った。trainingの２４時間後のtestにおいてfreezing％を測定したが、sham群とCLP群で有意差は検出できなかった。このことから、本研究で用いたCLPモデルでは、CLP後１週間時点では活動性が低下しているため、行動学の評価は不適当であること、CLP後２週間時点では、活動性が回復しているが、認知機能の低下の低下も検出できないことがわかった。このことから、CLPモデルでは活動性の低下の影響が長く続くため、行動学での認知機能低下の検出が難しい可能性があると考えている。
日本学術振興会, 基盤研究(C), 北海道大学, 21K08917 - Effect of anesthesia and surgery on postoperative cognitive dysfunction and dementia in senescence accelerated mouse
Grants-in-Aid for Scientific Research
01 Apr. 2018 - 31 Mar. 2021
Morimoto Yuji
We examined the effects of anesthesia and surgery on cognitive function in mice with aging and cognitive dysfunction. In contrast to normal mice, in which neuroinflammation was enhanced only after surgery, mice with cognitive impairment and aging showed increased inflammatory cytokines in the hippocampus even after anesthesia exposure alone, indicating enhanced neuroinflammation. However, behavioral studies failed to detect any postoperative cognitive dysfunction in the aged and cognitively impaired mice. The reason for this is that the cognitive function of the control group without anesthesia or surgery had already declined significantly, and the effects of anesthesia and surgery could not be detected.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 18K08843 - Mechanism of postoperative cognitive dysfunction-Examination from neuroinflammation
Grants-in-Aid for Scientific Research
01 Apr. 2013 - 31 Mar. 2017
Morimoto Yuji, HASEGAWA Kan, HOSHINO Koji
To investigate the effects of IL-1beta on synaptic plasticity, we examined long-term potentiation (LTP) electrophysiologically in different hippocampal regions in acute mouse brain slices. Our results demonstrated that IL-1beta exerted variable effects on LTP at different kinds of synapses, indicating that IL-1beta had synapse-specific effects on hippocampal synaptic plasticity.
Next, we investigated the effects of minocycline (MINO) on LTP in the hippocampus in a cecal ligation and puncture (CLP) mouse model. We have provided the evidence that MINO prevents impaired LTP related to sepsis-induced encephalopathy in the mouse hippocampus, and that mechanisms associated with IL-1 receptor activity may be involved.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 25462420 - 術後認知機能障害
2013
森本 裕二
Principal investigator, Competitive research funding - Mechanism of neurotoxicity by anesthetics in the developing brain-Effect of hypercapnia
Grants-in-Aid for Scientific Research
2010 - 2012
MORIMOTO Yuji, TACHIBANA Kaori, TSURUGA Kenkichi
To investigate the possible long-term consequences of neonatal exposure to hypoxic hypercapnia regarding learning ability, we investigated the effect of neonatal hypoxic hypercapnia on later functions in the hippocampus. Neonatal rat pups (postnatal day 7; P7) were exposed to a high concentration of carbon dioxide (CO2; 13%) for 2 or 4 h. Exposure to CO2 in P7 rat pups disrupted later learning acquisition, as assessed in 10-week-old adult rats subjected to a Morris water maze test. Induction of long-term potentiation (LTP) in the synapses of the hippocampal CA1 area was also impaired, whereas the paired-pulse responses of population spikes exhibited a significant increase in CO2-exposed rats. Such long-lasting modifications in hippocampal synaptic plasticity may contribute to the learning impairments associated with perinatal hypoxic hypercapnia and acidosis.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 22591699 - The neuronal toxicity of general anesthetics on the developing rat brain
Grants-in-Aid for Scientific Research
2006 - 2007
MORIMOTO Yuji, TACHIBANA Kaori, YOSHIOKA Mitsuhiro, TSURUGA Kenkichi
It was recently shown that exposure of commonly used general anesthetics to the developing rat brain during the peak of synaptogenesis can trigger widespread apoptotic neurodegeneration in the brain, especially in the hippocampus. This can cause the persistent learning/memory deficits later on life. This study examined whether pentobarbital, an anesthetic with GABAergic property, administered to neonate rats, can trigger the behavioral and electrophysiological deficits occur later in adulthood. Rats administered pentobarbital (10 and 20 mg/kg, i.p.) on the 7th day after birth (7PD) displayed suppressed the hippocampal long-term potentiation (LTP) at 10-12 weeks old. Paired-pulse facilitation was augmented by pentobarbital, suggesting the presynaptic depression in the hippocampus. The behavioral exploration, tested by the open field test, showed the tendency of suppression. Exploration in the open-field test has shown to correlate to the hippocampal function, i.e. spatial memory and learning. These data suggest that administration of pentobarbital during a critical stage of brain development may result in functional deficits of hippocampus in adulthood. On the other hand, blood gas analysis during the pentobarbital anesthesia at 7PD induced the critical hypoxia and/or systemic acidosis via the respiratory depression. Given that neonatal hypoxia and/or systemic acidosis can cause the hippocampal dysfunction later on life, we have to take that bias into consideration when discussing the functional deficits induced by pentobarbital during a critical stage of neonatal brain development.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 18591683 - シナプス形成期における麻酔薬の神経毒性
科学研究費助成事業
2005 - 2006
森本 裕二
シナプス形成期の未成熟脳が麻酔に暴露されると広範囲に細胞死が起こることが、報告されている(J Neurosci 2003;23:876)。ある種の麻酔の組み合わせで、NMDAレセプタの遮断とGABAレセプタの賦活が同時に生じると神経細胞の活動が異常に抑制され、その結果、細胞死に至るという機序が推測されている。しかし、この知見に関する報告はまだ極めて少なく、機序も推測の域を出ない。
本研究ではグリア細胞を排除した選択的初代神経培養系を確立し、上記知見を追試するとともに、その機序について検討を行った。
妊娠18日のWisterラットから胎児を摘出し、開頭の後に大脳を摘出し、前脳を分離し、得られた神経細胞を培養皿上に散布した。培養液はNeurobasal mediumを用い、グリア等を排除した選択的神経細胞培養を使用した。
まず、NMDA拮抗薬MK801とGABAの組み合わせで、負荷1日後の神経細胞死を評価し、培養14日後の細胞で神経細胞死が有意に助長されたが、それより前の7日後、後の21日後では有意な変化は認めなかった。吸入麻酔薬のイソフルランでも同様な結果が見られ、培養神経細胞でも麻酔薬に障害作用がある事、さらにはその障害作用にはtime windowがある事を確認した。次に、細胞死がアポトーシスとネクローシスかを鑑別するため、蛍光顕微鏡(propidium iodide、Ho342染色)による形態学的解析を行った。結果、ネクローシスと比較して、アポトーシスが主に起こることが証明された。
以上より、選択的初代神経培養系においても、NMDAレセプタの遮断とGABAレセプタの賦活でtime windowを有した神経細胞死が生じ、これは主にアポトーシスの進行によることが確認された。
日本学術振興会, 萌芽研究, 北海道大学, 17659482 - anesthetic neuroroxicity
2005
MORIMOTO Yuji
Principal investigator, Competitive research funding - 吸入麻酔薬の作用機序-超短パルスレーザーを用いた神経細胞膜の動的変化による解析
科学研究費助成事業
2003 - 2004
森本 裕二
吸入麻酔薬の作用機序は、これまで色々な角度から検討されてきたにもかかわらず、未だ確定していない。超短パルスレーザーによる細胞膜の動的構造変化の解析は物理化学的手法の中でも高感度で、かつ生理学的条件に近い環境で測定できる方法であるが、これを用いて吸入麻酔薬の作用機序を検討した報告は内外に見あたらない。私たちはこの方法を用い、吸入麻酔薬の生体膜脂質に対する影響を検討した。平成15年度は、生体膜としてヒト赤血球膜脂質を採用し,セボフルラン濃度5%に対する膜脂質流動性変化でも、温度がわずか2℃上昇した時と等価であり、その変化は極めて小さいという結論を得た。平成16年度はセボフルレンとイソフルレンの人工脂質膜に対する影響について調べた。
【方法】DPPC(Dipalmitoyl-L-α-Phosphatidylcholine)で単層脂質膜を作製した。吸入麻酔薬セボフルレンとイソフルレン溶解液はそれぞれ0.1,0.2,0.5,1,2,4mMに調製した。ガスクロマトグラフィで測定した溶解液の麻酔薬含有量はセボフルレン溶液では0.1mM≒0.7MAC,0.5mM≒2.8MAC、イソフルレン溶液ではそれぞれ0.5MACと2MACであった。脂質膜の粘性変化は蛍光偏光解消法により蛍光異光度を測定することで相転移温度を算出し評価した。
【結果】麻酔薬未投与の場合、相転移温度は42℃であったのに対して、濃度が0.2mM以下の場合もほぼ同じく42℃と有意な変化を認めなかった。0.5mM以上ではじめて約2℃低くなり、相転移温度が40℃前後に低下した。
【考察】臨床濃度(〜2MAC)での脂質膜流動性の変化は少なく、臨床濃度を超えた濃度ではじめて流動性亢進(粘性低下)が認められた。以上より、臨床濃度の吸入麻酔薬の膜脂質に対する影響は極めて小さく、作用機序としての膜脂質の可能性は小さいと考えられた。
日本学術振興会, 萌芽研究, 北海道大学, 15659364 - Effect of mild hypothermia and barbiturate for cerebral ischemia-Evaluation by using primary neuronal culture
Grants-in-Aid for Scientific Research
2001 - 2002
MORIMOTO Yuji
It has been reported that mild hypothermia and anesthetics such as barbiturates are neuroprotecitve. However, the mechanism of this protective effect has not been well clarified. We evaluated the effect of hypothermia and pentobarbital on glutamate neurotoxicity in rat cortical neurons.
Rat embryonic cortical neurons were obtained from timed pregnant rats at 18 days gestation. They were maintained in serum-free medium (Neurobasal medium supplemented with B-27 and N-2) for 6 days. The nearly pure neuronal population was obtained by this culture system. After exposure to 50 μM glutamate for 30 min, hypothermia or pentobarbital was induced. After 24 hours, neurotoxicity was evaluated by a leakage assay of lactic dehydogenase. Neuroprotective effect was seen in hypothermia (33 and 30 ℃), but not in clinical doses of pentobarbital. However, induction of hypothermia only during exposure to glutamate did not show any protective effect. Second, production of ROS (measured by flow cytometry with a ROS-specific fluorogen, C-DCDHF-DA) and caspase-3 activation (measured by DEVD-p-nitroaniline cleavage assays) was not inhibited by hypothermia after exposure of glutamate.
Our data indicated that hypothermia is neuroprotective against exposure to glutamate by inhibiting any cascade after the exposure, but not by inhibiting direct effect of glutamate during exposure. However, we did not make clear what cascade was inhibited by hypothermia in this study.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), HOKKAIDO UNIVERSITY, 13671556 - Protective effect of mild hypothermia and barbiturate for cerebral ischemia-Evaluation by using neuronal cells-
Grants-in-Aid for Scientific Research
1999 - 2000
MORIMOTO Yuji, WATANABE Satoshi
It has been reported that mild hypothermia and barbiturate are neuroprotecitve. However, the mechanism of this protective effect has not been well clarified. One possible mechanism is the inhibition of neuronal apoptosis. We evaluated the effect of hypothermia (29-35℃) and pentobarbital on apoptosis in neuronal cells using PC 12 cells, which is derived from rat pheochromocytoma. We further evaluated the mechanism of protective effect from the viewpoints of production of reactive oxygen species (ROS) and caspase activation
Apoptosis was induced by depriving serum from the medium, which is one of the most representative methods to induce apoptosis in PC 12 cells. First, cytotoxicity (evaluated by a leakage assay of lactic dehydogenase) and the percentage of apoptotic cells (calculated by flow cytometry with propidium iodide) were evaluated 4 days after induction of apoptosis. Second, production of ROS was measured by flow cytometry with a ROS-specific fluorogen, C-DCDHF-DA 3 or 6 hours after induction. Third, caspase-2 and -3 activation was measured by VDVAD p-nitroaniline and DEVD-p-nitroaniline cleavage assays 15 hours after induction.
Hypothermia (29 - 35℃) and clinical dose of pentobarbital significantly decreased cytotoxicity and the percentage of apoptotic cells. At 37℃ the production of ROS has already increased almost twice compared to control 3 hours after induction of apoptosis. Clinical dose of pentobarbital significantly decreased ROS production whereas hypothermia did not inhibit it. Caspase-2 and -3 activity was not inhibited by hypothermia and pentobarbital, although the activity increased by the induction of apoptosis.
Our data indicated that hypothermia (29 - 35℃) and clinical dose of pentobarbital inhibited induced apoptosis in neuronal cells. Inhibition of ROS production may be partly attributable to this protection by barbiturate. However, production of ROS and caspase activation may not be related to the mechanism of protective effect of hypothermia.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), HOKKAIDO UNIVERSITY, 11671474 - 神経細胞のアポトーシスに及ぼす各種麻酔薬の影響
科学研究費助成事業
1997 - 1998
森本 裕二
ある種の静脈麻酔薬や吸入麻酔薬、昨今では軽度低体温に脳保護効果があることが注目されている。最近の研究では、その機序が単に代謝の抑制ではなく、その他の機序の関与が示唆されているが、いまだ確定していない。ネクローシスは主に細胞内エネルギー欠乏により起こるため、代謝の抑制がネクローシス抑制につながりうる。しかしアポトーシスは、細胞内カルシウム濃度の増加、遺伝子の発現、ある種の蛋白分解酵素(caspase)の活性化など、細胞内カスケードの活性化によって起こる。すなわち、代謝抑制ではなく、これらカスケード抑制がアポトーシス抑制につながる可能性がある。そこで私たちは、麻酔薬、軽度低体温の保護効果の機序が、上記カスケードを抑制する結果、アポトーシスを抑制するのではないかという仮説をたてた。平成9年度は静脈麻酔薬が神経系アポトーシスにどのような影響を与えるか検討した。平成10年度は低体温、吸入麻酔薬の影響を検討した。
神経系細胞のモデルとしてラット副腎髄質褐色細胞腫由来のPC12細胞を用い、培養液からの血清除去によりアポトーシスを誘導した。評価は細胞死の判定とアポトーシス細胞の定量化で行った。すなわち、細胞死の判定は培養液中に遊離した乳酸脱水素酵素活性によって、アポトーシス細胞の定量化は細胞をアルコール固定後ヨウ化プロピジウムで染色しフローサイトメトリーによりDNA含量を測定し行った。結果、29-37℃の低体温は温度依存性に、細胞死ならびにアポトーシス細胞の割合の増大を抑制した。一方、イソフルラン、セボフルランなどの吸入麻酔薬にはアポトーシス抑制効果を認めなかった。本研究により、神経系アポトーシスに対して軽度低体温が抑制的であることが初めて明らかにされた。
日本学術振興会, 奨励研究(A), 北海道大学, 09771133 - 脳虚血時の伝達物質放出と麻酔薬の抑制効果-海馬スライスを用いた解析-
科学研究費助成事業
1996 - 1996
森本 裕二
脳虚血時種々の伝達物質が放出される。特にグルタミン酸などの興奮性アミノ酸の放出は、興奮性神経細胞死の原因として注目されている。in vivoの研究では対照群も麻酔下の状態にあり、実際麻酔薬が非麻酔下の状態と比較して伝達物質の放出を抑制するか不明である。したがってラットの海馬スライスに虚血様侵襲を加えて以下の実験を行った。Wister系ラットから麻酔下に大脳半球を摘出しマイクロスライサ-にて350μmの厚さの海馬スライスを作製した。グルコースを除去した人工脳脊髄液で満たされた小dishにスライスを移し、このdishを100%窒素で飽和させたincubatorに移した。すなわちスライスをグルコース、酵素を除去した状態に暴露しin vitroでの虚血様侵襲とした。虚血様侵襲と同時に吸入麻酔薬(イソフルレン、ハロセン)、静脈麻酔薬(ペントバルビタール、プロポフォール)のいずれかを負荷した。虚血様侵襲によりdishの人工脳脊髄液内に放出された興奮正アミノ酸(グルタミン酸、アスパラギン酸)を高速液体クロマトグラフィーにより測定した。コントロールとして塩化カリウム負荷により脱分極させ興奮性アミノ酸を放出させた切片を使用した。一時間の虚血様侵襲により興奮性アミノ酸はコントロールと比較して6倍も上昇した。この上昇はイソフルレン、ハロセンで約1/3に、ペントバルビタールで約半分に抑制されたが、プロポフォールでの抑制効果はみられなかった。以上より、ある種の麻酔薬では虚血様侵襲による興奮性アミノ酸上昇を抑制することが判明した。なお本研究施行中にアメリカのグループより同様の報告がなされたため、新たに脳切片培養を用い興奮性アミノ酸上昇抑制効果と予後との関係を検討すべく研究計画を企図中である。
日本学術振興会, 奨励研究(A), 北海道大学, 08771169 - 麻酔中の脳酸素化変化
1996
Competitive research funding - Cerebral oxygenated state during anesthesia
1996
Competitive research funding - 維代培養細胞を用いた虚血性神経細胞障害の機序及び各種薬物の保護的効果に関する検討-フローサイトメリ-法による解析-
科学研究費助成事業
1994 - 1994
森本 裕二
1.虚血性神経細胞障害時の細胞内Ca^<2+>上昇の機序とその意義:NG108-15細胞に低酸素無グルコース負荷により虚血性侵襲を与え、細胞外Ca^<2+>除去および細胞内Ca^<2+>キレート剤であるBAPTA-AM添加時の生存率をフローサイトメトリーにより測定した。その結果、単に虚血性侵襲のみを加えた場合と比較して、これら負荷時の生存率に有意な増加を認めなかった。したがって、低酸素無グルコース負荷によるNG108-15細胞障害の機序に、細胞内外からのCa^<2+>流入は重要な役割を演じないと結論した。
2.神経虚血に付随するアシドーシスの影響とその機序:NG108-15細胞を種々の程度のアシドーシス下におき、低酸素無グルコース負荷により虚血性侵襲を与えた。その結果pH6.8からpH5.6の間で、pH7.4と比較して生存率の増加を認め、その増加率はpH6.2で最大であった。すなわち、この程度のアシドーシスは虚血性侵襲に対して保護効果を有することが明らかとなった。さらに、この保護効果の機序につきCa^<2+>動態と細胞内エネルギー保存の両面から検討を加えた。その結果後者が重要な機序となる可能性が示唆された。また乳酸アシドーシス単独の細胞浮腫と生存率に及ぼす影響についても検討を行った。この結果、生存率低下はpH、乳酸濃度依存性に起こるが細胞浮腫は非依存性であり浮腫が細胞障害の直接的原因ではないと結論した。
3.虚血後の酸素負荷の影響とその機序:低酸素無グルコース負荷後の純酸素と大気それぞれに暴露した2群を設定し、その生存率を比較したが有意差は認めなかった。
4.薬物の影響については、L型Ca^<2+>チャネル拮抗剤であるニカルジピンは生存率に対して効果を認めなかった。乳酸アシドーシスによる細胞浮腫に対して、浸透圧利尿薬やループ利尿薬と比較してNa^+/H^+交換阻害薬に最も抗浮腫効果を認めた。
日本学術振興会, 奨励研究(A), 北海道大学, 06771177 - mRNA注入受容体発現モデルを用いた細胞内2次情報伝達系に対する麻酔薬の作用
科学研究費助成事業
1993 - 1993
太田 善博, 森本 裕二
本研究では、細胞内二次情報伝達系に対する揮発性麻酔薬の影響を検討するためにラット脳より抽出したmRNAをアフリカツメガエルに注入し、中枢神経系モデルを作成した。このモデルでは代謝調節型受容体、G蛋白質、phospholipase C(PLC),inositoltrisphosphate(IP3)を介して,Ca^<2+>が放出されCl^-チヤネルが開口し、最終的にCl^-電流が観察される。このCl^-電流を指標として一連の細胞内情報伝達系に対する揮発性麻酔薬の影響の解析が可能となる。本研究では代謝調節型受容体のアゴニストとして5-hydroxy-triptamine(5-HT)を用いた。さらに直接細胞内にIP_3,Ca^<2+>を注入して誘発されるCl^-電流を指標に揮発性麻酔薬の作用点の同定を行った。
揮発性麻酔薬であるハロタン,イソフルラン,メトキシフルランのいずれも、5-HT誘発性Cl^-電流を濃度依存性に抑制し、この変化は可逆的であった。メトキシフルレンによる濃度-反応曲線では、ED_<50>が右方偏位することなく最大値が抑制されたので非競合的抑制であることが示唆された。IP_3,Ca^<2+>注入によって誘発される電流応答はハロタン、イソフルラン、メトキシフルランのいずれによっても変化を認めなかった。
本研究の成績から以下の2点が明かとなった。
1)揮発性麻酔薬は代謝調節型受容体を介する細胞内二次情報伝達系を抑制した。
2)代謝調節型受容体、G蛋白質、PLCなどの細胞膜に存在する成分が揮発性麻酔薬の重要な作用点であることが示唆された。
日本学術振興会, 一般研究(C), 北海道大学, 05671246 - 脳虚血に対する麻酔薬の保護効果
1989
Competitive research funding - Protective effect of anesthetic agents on brain ischemia
1989
Competitive research funding - 心肺脳蘇生に及ぼす酸塩基平衡異常の影響
1987
Competitive research funding - The effect of abnormal acid-base status on cerbral cardiopulmonary resuscitation
1987
Competitive research funding
