Minowa Kazuyuki
| Faculty of Dental Medicine Division of Dental Medicine Department of Pathobiological Science | Professor |
| Hokkaido University Hospital | Professor |
Last Updated :2025/06/07
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Educational Organization
- Bachelor's degree program, School of Dental Medicine
- Doctoral (PhD) degree program, Graduate school of Dental Medicine
■Career
■Research activity information
Papers
- Diagnosis of skull-base invasion by nasopharyngeal tumors on CT with a deep-learning approach.
Junichi Nakagawa, Noriyuki Fujima, Kenji Hirata, Taisuke Harada, Naoto Wakabayashi, Yuki Takano, Akihiro Homma, Satoshi Kano, Kazuyuki Minowa, Kohsuke Kudo
Japanese journal of radiology, 27 Jan. 2024, [Domestic magazines]
English, Scientific journal, PURPOSE: To develop a convolutional neural network (CNN) model to diagnose skull-base invasion by nasopharyngeal malignancies in CT images and evaluate the model's diagnostic performance. MATERIALS AND METHODS: We divided 100 malignant nasopharyngeal tumor lesions into a training (n = 70) and a test (n = 30) dataset. Two head/neck radiologists reviewed CT and MRI images and determined the positive/negative skull-base invasion status of each case (training dataset: 29 invasion-positive and 41 invasion-negative; test dataset: 13 invasion-positive and 17 invasion-negative). Preprocessing involved extracting continuous slices of the nasopharynx and clivus. The preprocessed training dataset was used for transfer learning with Residual Neural Networks 50 to create a diagnostic CNN model, which was then tested on the preprocessed test dataset to determine the invasion status and model performance. Original CT images from the test dataset were reviewed by a radiologist with extensive head/neck imaging experience (senior reader: SR) and another less-experienced radiologist (junior reader: JR). Gradient-weighted class activation maps (Grad-CAMs) were created to visualize the explainability of the invasion status classification. RESULTS: The CNN model's diagnostic accuracy was 0.973, significantly higher than those of the two radiologists (SR: 0.838; JR: 0.595). Receiver operating characteristic curve analysis gave an area under the curve of 0.953 for the CNN model (versus 0.832 and 0.617 for SR and JR; both p < 0.05). The Grad-CAMs suggested that the invasion-negative cases were present predominantly in bone marrow, while the invasion-positive cases exhibited osteosclerosis and nasopharyngeal masses. CONCLUSIONS: This CNN technique would be useful for CT-based diagnosis of skull-base invasion by nasopharyngeal malignancies. - Blockage of CSF Outflow in Rats after Deep Cervical Lymph Node Ligation Observed Using Gd-based MR Imaging.
Naoya Kinota, Hiroyuki Kameda, Bai Xiawei, Takaaki Fujii, Daisuke Kato, Bunya Takahashi, Ryo Morita, Daisuke Abo, Ryusei Majima, Hiroshi Ishii, Kazuyuki Minowa, Kohsuke Kudo
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 30 May 2023, [Domestic magazines]
English, Scientific journal, PURPOSE: To investigate whether deep cervical lymph node (DCLN) ligation alters intracranial cerebrospinal fluid (CSF) tracer dynamics and outflow using a rat model with intrathecal dynamic contrast-enhanced (DCE) MRI. METHODS: Six bilateral DCLN-ligated and six sham-operated rats were subjected to DCE MRI with Gd-BTDO3A, and dynamic T1-weighted images were acquired. ROIs were collected from the CSF at the C1 level (CSF_C1), CSF between the olfactory bulbs (CSF_OB), CSF at the pituitary recess (CSF_PitR), and CSF at the pineal recess (CSF_PinR), upper nasal turbinate (UNT), olfactory bulbs, cerebrum, and the jugular region. Time-intensity curves were evaluated, and the maximum slope, peak timing, peak signal ratio, and elimination half-life for the four CSF ROIs and UNT were calculated and compared. RESULTS: Delayed tracer arrival in the rostral CSF space and the nasal cavity with tracer retention in the ventral CSF space were observed in the ligation group. The maximum slopes were smaller in the ligation group at UNT (sham: 0.075 ± 0.0061, ligation: 0.044 ± 0.0086/min, P = 0.011). A significant difference was not detected in peak timings. The peak signal ratio values were lower in the ligation group at UNT (sham: 2.12 ± 0.19, ligation: 1.72 ± 0.11, P = 0.011). The elimination half-life was delayed in the ligation group at CSF_C1 (sham: 30.5 ± 2.70, ligation: 44.4 ± 12.6 min, P = 0.043), CSF_OB (sham: 30.2 ± 2.67, ligation: 44.8 ± 7.47 min, P = 0.021), and CSF_PitR (sham: 30.2 ± 2.49, ligation: 41.3 ± 7.57 min, P = 0.021). CONCLUSION: The DCLN ligation in rats blocked CSF outflow into the nasal cavity and caused CSF retention. - Objective Evaluation of Oral and Pharyngeal Areas in Autopsy Cases of Obstructive Sleep Apnea Syndrome via Postmortem CT.
Akiko Takeuchi, Hideki Hyodoh, Shigeki Jin, Satoshi Tanaka, Manabu Murakami, Kazuyuki Minowa, Kotaro Matoba
Current medical imaging, 28 Mar. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: Obstructive sleep apnea syndrome (OSAS) can cause sudden death during sleep. Previous findings have suggested that OSAS development is related to maxillofacial morphology. Evaluation of facial morphology can determine the risk of developing the disease, and establishing an objective method to assess the underlying etiology of OSAS-related death would be advantageous. OBJECTIVE: The objective of this study is to determine the key features of obstructive sleep apnea syndrome (OSAS) using postmortem oral and pharyngeal computed tomography (CT). METHODS: We retrospectively assessed autopsy cases of patients with (n=25) and without (n=25) OSAS-related death. We used oral and pharyngeal CT images to compare the oral and pharyngeal cavity volume (OPCV), oral and pharyngeal soft tissue volume (OPSV), oral and pharyngeal air space volume (OPAV), and OPAV to OPCV ratio (%air). Receiver operating curve (ROC) analysis was used to determine the accuracy of OSAS prediction. We assessed participants with body mass index (BMI) values within the normal range. RESULTS: Among the 50 subjects, we observed significant between-group differences in OPSV, OPAV, and % air, whereas there were significant between-group differences in OPSV and %air among 28 subjects with normal BMI values. Both comparisons suggested that OSAS-related death was associated with low %air and high OPSV values. CONCLUSION: The %air and OPSV are useful for assessing postmortem oropharyngeal CT images. OSAS-related sudden death is likely when %air and OPSV values are ≤20.1% and ≥127.2 ml, respectively. Among those with normal BMI values, % air and OPSV values of ≤22.8% and ≥111.5 ml, respectively, predict OSAS-related sudden death. - Non-Gaussian model-based diffusion-weighted imaging of oral squamous cell carcinoma: associations with Ki-67 proliferation status.
Tomoka Shima, Noriyuki Fujima, Shigeru Yamano, Hiroyuki Kameda, Masaaki Suzuka, Akiko Takeuchi, Yurika Kinoshita, Nanami Iwai, Kohsuke Kudo, Kazuyuki Minowa
Oral radiology, 27 Mar. 2023, [Domestic magazines]
English, Scientific journal, OBJECTIVES: To investigate possible associations between diffusion-weighted imaging (DWI) parameters derived from a non-Gaussian model fitting and Ki-67 status in patients with oral squamous cell carcinoma (OSCC). METHODS: Twenty-four patients with newly diagnosed OSCC were prospectively recruited. DWI was performed using six b-values (0-2500). The diffusion-related parameters of kurtosis value (K), kurtosis-corrected diffusion coefficient (DK), diffusion heterogeneity (α), distributed diffusion coefficient (DDC), slow diffusion coefficient (Dslow), and apparent diffusion coefficient (ADC) were calculated from four diffusion fitting models. Ki-67 status was categorized as low (Ki-67 percentage score < 20%), middle (20-50%), or high (> 50%). Kruskal-Wallis tests were performed between each non-Gaussian diffusion model parameters and Ki-67 grade. RESULTS: The Kruskal-Wallis tests revealed that multiple parameters (K, ADC, Dk, DDC and Dslow) showed statistically significant differences between the three levels of Ki-67 status (K: p = 0.020, ADC: p = 0.012, Dk: p = 0.027, DDC: p = 0.007 and Dslow: p = 0.026). CONCLUSIONS: Several non-Gaussian diffusion model parameters and ADC values were significantly associated with Ki-67 status and have potential as promising prognostic biomarkers in patients with OSCC. - Utility of the deep learning technique for the diagnosis of orbital invasion on CT in patients with a nasal or sinonasal tumor.
Junichi Nakagawa, Noriyuki Fujima, Kenji Hirata, Minghui Tang, Satonori Tsuneta, Jun Suzuki, Taisuke Harada, Yohei Ikebe, Akihiro Homma, Satoshi Kano, Kazuyuki Minowa, Kohsuke Kudo
Cancer imaging : the official publication of the International Cancer Imaging Society, 22, 1, 52, 52, 22 Sep. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: In nasal or sinonasal tumors, orbital invasion beyond periorbita by the tumor is one of the important criteria in the selection of the surgical procedure. We investigated the usefulness of the convolutional neural network (CNN)-based deep learning technique for the diagnosis of orbital invasion, using computed tomography (CT) images. METHODS: A total of 168 lesions with malignant nasal or sinonasal tumors were divided into a training dataset (n = 119) and a test dataset (n = 49). The final diagnosis (invasion-positive or -negative) was determined by experienced radiologists who carefully reviewed all of the CT images. In a CNN-based deep learning analysis, a slice of the square target region that included the orbital bone wall was extracted and fed into a deep-learning training session to create a diagnostic model using transfer learning with the Visual Geometry Group 16 (VGG16) model. The test dataset was subsequently tested in CNN-based diagnostic models and by two other radiologists who were not specialized in head and neck radiology. At approx. 2 months after the first reading session, two radiologists again reviewed all of the images in the test dataset, referring to the diagnoses provided by the trained CNN-based diagnostic model. RESULTS: The diagnostic accuracy was 0.92 by the CNN-based diagnostic models, whereas the diagnostic accuracies by the two radiologists at the first reading session were 0.49 and 0.45, respectively. In the second reading session by two radiologists (diagnosing with the assistance by the CNN-based diagnostic model), marked elevations of the diagnostic accuracy were observed (0.94 and 1.00, respectively). CONCLUSION: The CNN-based deep learning technique can be a useful support tool in assessing the presence of orbital invasion on CT images, especially for non-specialized radiologists. - Evaluation of oral air space volume in obstructive sleep apnea syndrome using clinical and postmortem CT imaging.
Akiko Takeuchi, Hideki Hyodoh, Kotaro Matoba, Manabu Murakami, Kohsuke Kudo, Kazuyuki Minowa
Oral radiology, 20 Mar. 2021, [Domestic magazines]
English, Scientific journal, OBJECTIVES: Obstructive sleep apnea syndrome (OSAS) induces upper airway occlusion and may cause sudden death during sleep. This study sought to clarify the relationship between oral air space volume and OSAS onset, which is influenced by multiple factors, such as jawbone, dentition morphology, and oral soft-tissue volume. METHODS: (1) 50 subjects from deceased cases were divided into two groups: OSAS (25 subjects) and controls (25 subjects). (2) 28 subjects from clinical cases were divided into two groups: OSAS (9 subjects) and controls (19 subjects). In all cases, the Computed Tomography (CT) images of the facial region were obtained, and four parameters of oral area volume were analyzed in deceased and clinical cases, and comparisons and analyses were performed between OSAS and control cases. In addition, the efficiency of measurement of these parameters was evaluated using Receiver Operating Characteristic (ROC) curves in OSAS. RESULTS: (1) In deceased cases, oral soft-tissue volume (OSV), oral air-space volume (OAV), and the ratio of OAV to OSV (%air) showed a significant correlation. (2) In clinical cases, OAV and %air showed a significant correlation. In both postmortem and clinical images, a small %air value indicates a high risk of developing OSAS and a high probability of OSAS-related sudden death. CONCLUSIONS: It was shown that the %air is an index to evaluate OSAS by CT imaging of the oral region. OSAS may be indicated when the %air value is ≦ 16.0% in deceased cases and ≦ 6.6% in clinical cases. - Quantification of Joint Space Width Difference on Radiography Via Phase-Only Correlation (POC) Analysis: a Phantom Study Comparing with Various Tomographical Modalities Using Conventional Margin-Contouring
Aimi Taguchi, Shun Shishido, Yafei Ou, Masayuki Ikebe, Tianyu Zeng, Wanxuan Fang, Koichi Murakami, Toshikazu Ueda, Nobutoshi Yasojima, Keitaro Sato, Kenichi Tamura, Kenneth Sutherland, Nozomi Oki, Ko Chiba, Kazuyuki Minowa, Masataka Uetani, Tamotsu Kamishima
Journal of Digital Imaging, 34, 1, 96, 104, Springer Science and Business Media LLC, 02 Dec. 2020
Scientific journal - 閉塞性睡眠時無呼吸症候群(OSAS)における口腔領域の画像評価に関する研究
竹内 明子, 兵頭 秀樹, 的場 光太郎, 箕輪 和行
北海道歯学雑誌, 39, 2, 159, 159, 北海道歯学会, Mar. 2019
Japanese - 口腔がん再建術後に中心静脈カテーテル関連深部静脈血栓症を生じた2例 DVTに対する歯科医師の対応について
秦 浩信, 佐藤 明, 宮腰 昌明, 吉川 和人, 清水 六花, 林 利彦, 箕輪 和行, 北川 善政
日本口腔腫瘍学会誌, 29, 1, 1, 8, (一社)日本口腔腫瘍学会, Mar. 2017
Japanese - クローズドロックに継発する前歯部開咬の臨床的特徴
後藤田章人, 山口泰彦, 金子知生, 岡田和樹, 三上紗季, 箕輪和行, 井上農夫男
日補綴会誌, 8, 281, 288, 2016, [Peer-reviewed]
Japanese, Scientific journal - CT検査と口腔内超音波検査による口腔腫瘍の原発部位診断
志摩 朋香, 西田 睦, 入澤 明子, 鈴鹿 正顕, 山野 茂, 大森 桂一, 箕輪 和行
超音波医学, 42, Suppl., S701, S701, (公社)日本超音波医学会, Apr. 2015
Japanese - Magnetic Displacement Force and Torque on Dental Keepers in the Static Magnetic Field of an MR Scanner
Mika Omatsu, Takayuki Obata, Kazuyuki Minowa, Koichi Yokosawa, Eri Inagaki, Kinya Ishizaka, Koichi Shibayama, Toru Yamamoto
JOURNAL OF MAGNETIC RESONANCE IMAGING, 40, 6, 1481, 1486, Dec. 2014, [Peer-reviewed]
English, Scientific journal - A case of pigmented villonodular synovitis, with few clinical symptoms, arising from the temporomandibular joint
Kazuki Okada, Taihiko Yamaguchi, Kazuyuki Minowa, Yasunori Totsuka, Masanobu Shindoh, Nobuo Inoue
Oral Radiology, 29, 1, 74, 79, Jan. 2013, [Peer-reviewed]
English, Scientific journal - MRI diagnosis for masticatory muscle tendon-aponeurosis hyperplasia
MINOWA Kazuyuki
Gakukansetsu Kenkyukaishi, 21, 1, 40, 45, The Japanese Society for Temporomandibular Joint, 20 Apr. 2009
Japanese - Static bone cavity in the condylar neck and mandibular notch of the mandible
K. Minowa, I. Kobayashi, A. Matsuda, K. Ohmori, Y. Kurokawa, N. Inoue, Y. Totsuka, M. Nakamura
AUSTRALIAN DENTAL JOURNAL, 54, 1, 49, 53, Mar. 2009, [Peer-reviewed]
English, Scientific journal - 悪性腫瘍との鑑別に苦慮した下顎骨骨髄炎の一例
格口 渉, 馬渕 亜希子, 大廣 洋一, 箕輪 和行, 鄭 漢忠, 進藤 正信, 戸塚 靖則
日本口腔外科学会雑誌, 54, 1, 26, 26, (公社)日本口腔外科学会, Jan. 2008
Japanese - Static bone cavity of the mandible: Computed tomography findings with histopathologic correlation
K. Minowa, N. Inoue, Y. Izumiyama, Y. Ashikaga, B. Chu, K. R. Maravilla, Y. Totsuka, M. Nakamura
ACTA RADIOLOGICA, 47, 7, 705, 709, Sep. 2006, [Peer-reviewed]
English, Scientific journal - 下歯槽神経臼歯枝由来と考えられた下顎骨中心性神経鞘腫の1例
吉川 和人, 榊原 典幸, 佐藤 明, 寺田 典子, 石川 誠, 野谷 健一, 北川 善政, 飯塚 正, 箕輪 和行
日本口腔外科学会雑誌, 52, 7, 433, 433, (公社)日本口腔外科学会, Jul. 2006
Japanese - The influence of tissue blood flow volume on energy metabolism in masseter muscles
K Okada, T Yamaguchi, K Komatsu, T Matsuki, A Gotouda, K Minowa, N Inoue
CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE, 23, 3, 166, 173, Jul. 2005, [Peer-reviewed]
English, Scientific journal - The influence of hot pack therapy on the blood flow in masseter muscles
K Okada, T Yamaguchi, K Minowa, N Inoue
JOURNAL OF ORAL REHABILITATION, 32, 7, 480, 486, Jul. 2005, [Peer-reviewed]
English, Scientific journal - Impacted teeth in the maxilla: usefulness of 3D Dental-CT for preoperative evaluation
T Sawamura, K Minowa, M Nakamura
EUROPEAN JOURNAL OF RADIOLOGY, 47, 3, 221, 226, Sep. 2003, [Peer-reviewed]
English, Scientific journal - Electromyographic activity of the jaw-closing muscles during jaw opening - comparison of cases of masseter muscle contracture and TMJ closed lock
T Yamaguchi, K Satoh, K Komatsu, K Kojima, N Inoue, K Minowa, Y Totsuka
JOURNAL OF ORAL REHABILITATION, 29, 11, 1063, 1068, Nov. 2002, [Peer-reviewed]
English, Scientific journal - Electromyographic activity of the jaw-closing muscles during jaw opening in patients with masseter muscle contracture
T Yamaguchi, K Satoh, K Komatsu, N Inoue, K Minowa, Y Totsuka
CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE, 20, 1, 48, 54, Jan. 2002, [Peer-reviewed]
English, Scientific journal - Analyses of muscular activity, energy metabolism, and muscle fiber type composition in a patient with bilateral masseteric hypertrophy
K Satoh, T Yamaguchi, K Komatsu, N Inoue, K Minowa, T Kanayama, S Yoshida, N Ohata
CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE, 19, 4, 294, 301, Oct. 2001
English, Scientific journal - ヒト咬筋のエネルギー代謝と筋線維組成との関連性
佐藤 華織, 山口 泰彦, 井上 農夫男, 箕輪 和行, 山本 隆昭, 金山 健夫, 大畑 昇
日本補綴歯科学会雑誌, 45, 105回特別, 73, 73, (公社)日本補綴歯科学会, Jun. 2001
Japanese - Efficacy of postoperative physiotherapy in temporomandibular joint ankylosis
INOUE Nobuo, MURAKAMI Yuji, NISHIKATA Satoshi, ODA Mitsutaka, KOBAYASHI Takashi, YAMAGUCHI Hiro-o, SAITOH Shigeo, YURA Shin-ya, YAMAGUCHI Taihiko, MINOWA Kazuyuki, TOTSUKA Yasunori
北海道歯学雑誌, 21, 1, 77, 81, 15 Jun. 2000
English - Kimura's disease in the left submandibular region
T. Sawamura, K. Minowa, S. Abe, K. Ohmori, M. Nakamura
Oral Radiology, 12, 1, 40, 41, Springer Tokyo, 1996
English, Scientific journal - Computed tomograph system image for a radiation treatment planning using a shell and trial of the superposition of the MRI.
細川 洋一郎, 箕輪 和行, 澤村 強, 阿部 悟, 安田 元昭, 金子 正範, 大森 桂一, 中村 太保, 渡辺 良晴, 鎌田 正
Shika Hoshasen, 35, 3, 177, 181, Japanese Society for Oral and Maxillofacial Radiology, 1995
Japanese - Evaluation of an in vivo labeling method of red blood cells with99mTc-pertechnetate in the head and neck region
Tsuyoshi Sawamura, Yoichiro Hosokawa, Shuichi Takinami, Kazuyuki Minowa, Satoru Abe, Keiichi Ohmori, Motoyasu Nakamura
Oral Radiology, 10, 2, 35, 42, Springer-Verlag, Dec. 1994, [Peer-reviewed]
English, Scientific journal - Radiological findings of progressive systemic sclerosis accompanied by polymyositis in plain radiography
Tsuyoshi Sawamura, Kazufumi Suzuki, Kazuyuki Minowa, Satoru Abe, Keiichi Ohmori
Oral Radiology, 10, 2, 69, 70, Springer-Verlag, Dec. 1994, [Peer-reviewed]
English, Scientific journal - Characteristic findings of adenoid cystic carcinoma on MR imaging and differentiation from squamous cell carcinoma
Tsuyoshi Sawamura, Kazuyuki Minowa, Satoru Abe, Keiichi Ohmori, Yoichiro Hosokawa, Michio Yamasaki, Kazuo Miyasaka
Oral Radiology, 10, 2, 7, 13, Springer-Verlag, Dec. 1994, [Peer-reviewed]
English, Scientific journal - Unusual CT finding in neck lymph node involved by lymphoma
Yoichiro Hosokawa, Tsuyoshi Sawamura, Kazuyuki Minowa, Satoru Abe, Tadashi Kamada, Kazuo Miyasaka, Asad uz Zaman, Bernardo T. Acob
Oral Radiology, 10, 1, 63, 64, Springer-Verlag, Jun. 1994, [Peer-reviewed]
English, Scientific journal - An ameloblastoma divided into two parts on MRI
Yoichiro Hosokawa, Kazuyuki Minowa, Satoru Abe, Michio Yamasaki, Mohiuddin Ahmed, Takashi Kobayashi, Ichizo Kobayashi
Oral Radiology, 8, 1, 59, 61, Springer-Verlag, Jun. 1992, [Peer-reviewed]
English, Scientific journal - Analysis on the Time/Activity curve of salivary gland scintigraphy in salivary gland diseases. The Correlation between the pattern of Time/Activity curve and the amount of saliva.:The Correlation between the pattern of Time/Activity curve and the amounat of saliva
SUZUKI Kazufumi, HOSOKAWA Yoichiro, KANEKO Masanori, OHMORI Keiichi, MINOWA Kazuyuki, FUKUDA Hiroshi, YAMASAKI Michio
Journal of Oral Surgery Society of Japan, 38, 4, 584, 589, Japanese Society of Oral and Maxillofacial Surgeons, 1992
Japanese, Salivary gland scintigraphy with 99mTcO4- is a simple method to evaluate salivary gland function and has been available as a technique using a time/activity curve for a number of years. But, there were few reports on the relationship between the various patterns of the time/activity curvcs and the salivary flow rate from the gland. This presents correlation between the time/activity curve pattern and the salivary flow rate from the parotid gland.
65 patients complaining of xerostomia were examined.62 were female and 3 male (average age 45.6 years, range 17-69years).Their diagnosis were 26 Sjögren Syndrome, 28 suspicion of Sjögren Syndrome and 11 parotiditis.
The salivary flow rate from parotid gland was measured by stimulation with 10% citric acid using modified Carlson crittenden cup every 10 seconds for 5 min. 185 MBq 99mTcO4-was injected intravenously and sequential scintigraphy was perfbrmed. Time/activity curves were recorded on film. Six kinds of basic patterns werc followed; Normal pattern, Median pattern, Flat pattern and Sloped pattern (Mita et al 1981), Reaccumulation flat pattern and Poor secretion (Stimulant secretory ratio: less than 70%) pattern by us. The amount of saliva was as follows; Normal pattern (n=31): 5.4+0.4ml, Reaccumulation flat pattern (n=3): 4.2+0.6ml, Poor secretion pattern (n=18): 4.1+0.5ml, Median pattern (n=20): 3.5+0.5ml, Flat pattern (n=11): 2.6+0.5ml and Sloped pattern (n=1): 1.5ml. Normal pattern versus Poor secretion pattern, Median pattern and Flat pattern in the salivary flow rate were statistically significant as determined by Students, t-test.
We assessed the correlation between the pattern of time/activity curve in the salivary gland scintigraphy and the amount of saliva. - Invasion of the intracranial space by a malignant odontogenic mixed tumor: Report of a case
Yoichiro Hosokawa, Kazuyuki Minowa, Satoru Abe, Keiichi Ohmori, Michio Yamasaki, Masanobu Shindoh, Tadashi Iizuka, Mohiuddin Ahmed, Akira Amemiya
Oral Radiology, 7, 1, 1, 6, Springer-Verlag, Jun. 1991, [Peer-reviewed]
English, Scientific journal - The CT findings of maxillary sinusitis comparing with conventional radiography.
OHMORI Keiichi, HIRANO Masayasu, MINOWA Kazuyuki, KANEKO Masanori, YAMAZAKI Michio
Journal of Oral Surgery Society of Japan, 37, 4, 892, 896, Japanese Society of Oral and Maxillofacial Surgeons, 1991
Japanese, The CT findings of 42 patients with surgically verified benign lesions of the maxillary sinus were evaluated to demonstrate the value of Cl. Comparison with conventional radiologial methods was made.
1. The opacification of the maxillary sinus lumen in Waters view shows the relationship in proportion to the soft tissue that occupies the sinus in CT finding.
2. The thickening in the posterior wall of the maxillary antra may cause the opacification in Waters view.
3. The Waters view can depict rnore significantly the maxillary soft tissue in CT finding than the Caldwell view and panoramic view.
4. CT is of value in demonstration of fluid level, mucosal swelling, mucosal thickening and the thickening of the bony walls. - A case of arteriovenous malformation of the mandible: Diagnosis based on radiographical examinations.
HOSOKAWA Yoichiro, TAKAMURA Takazumi, MINOWA Kazuyuki, YAMAZAKI Michio, SHINDOH Masanobu, UY Henrry, AMEMIYA Akira, MIYASAKA Kazuo
Shika Hoshasen, 30, 2, 152, 162, Japanese Society for Oral and Maxillofacial Radiology, 1990
Japanese, An arteriovenous malformation is a direct communication between an artery and a vein, through which the blood flows the capillary circulation. A case of arteriovenous malformation of the mandible, diagnosed by different radiological examinations, is presented in this paper.
A 13-year-old boy was referred to our clinic with the chief complaint of swelling in the left cheek. The sound of blood flow could be heard and palpitation on the external carotid artery and facial vein was felt. Panoramic and PA view showed a well-defined multilocular radiolucency in the left mandible. CT showed the expansion of the blood vessels connected with this lesion. MRI revealed the flow void phenomenon in the expanded blood vessels. Conventional angiography disclosed the definite feeder, drainer and nidus of the arteries. At present we consider that it was an indispensable examination for the diagnosis of this condition. Such cases should be diagnosed by using the successful radiograhpic examinations. - A case of cyst type ameloblastoma of the right upper jaw with extensive involuement.
鈴木 一史, 細川 洋一郎, 箕輪 和行, 呉 明仁, 滝波 修一, 山崎 岐男
Shika Hoshasen, 30, 2, 174, 175, Japanese Society for Oral and Maxillofacial Radiology, 1990
Japanese - 上顎洞にみられたpneumosinus dilatansのCT
高村 敬純, 箕輪 和行, 金子 正範, 阿部 悟, 山崎 岐男, 宮坂 和男
歯科放射線, 29, 4, 442, 443, 特定非営利活動法人 日本歯科放射線学会, 1989
Japanese
Other Activities and Achievements
- 一般歯科医院顎関節症・口腔顔面痛外来における外来患者の臨床統計的報告
飯沼 英人, 竹内 明子, 志摩 朋香, 箕輪 和行, 和嶋 浩一, 日本歯科心身医学会雑誌, 33, 2, 125, 125, Dec. 2018
(一社)日本歯科心身医学会, Japanese - 一般歯科医院顎関節症・口腔顔面痛外来における外来患者の臨床統計的報告
飯沼 英人, 竹内 明子, 志摩 朋香, 箕輪 和行, 和嶋 浩一, 日本顎関節学会雑誌, 30, Suppl., 134, 134, Jul. 2018
(一社)日本顎関節学会, Japanese - 口腔がん再建術後に中心静脈カテーテル関連深部静脈血栓症を生じた2例 DVTに対する歯科医師の対応について
秦 浩信, 佐藤 明, 宮腰 昌明, 吉川 和人, 清水 六花, 林 利彦, 箕輪 和行, 北川 善政, 日本口腔腫瘍学会誌, 29, 1, 1, 8, Mar. 2017
(一社)日本口腔腫瘍学会, Japanese - 歯根膜への機械的刺激時の脳律動変調
佐藤 華織, 山口 泰彦, 前田 正名, 齋藤 大嗣, 佐久間 俊光, 箕輪 和行, 横澤 宏一, 下條 暁司, 前澤 仁志, 日本顎関節学会雑誌, 28, Suppl., 126, 126, Jul. 2016
(一社)日本顎関節学会, Japanese - CT検査と口腔内超音波検査による口腔腫瘍の原発部位診断
志摩 朋香, 佐藤 隆文, 入澤 明子, 鈴鹿 正顕, 山野 茂, 西田 睦, 箕輪 和行, 超音波医学, 42, 1, 91, 91, Jan. 2015
(公社)日本超音波医学会, Japanese - Diffusion-weighted MRI in head and Neck region
志摩 朋香, 箕輪 和行, 山野 茂, 金子 正範, 菱川 龍樹, 大森 桂一, 北海道歯学雑誌, 34, 2, 132, 133, Mar. 2014
北海道歯学会, Japanese - Laterality of the Corticospinal Tract and the Influence of Handedness : Findings of a DTI Study
THA Khin Khin, TERAE Satoshi, HAMAGUCHI Hiroyuki, ISHIZAKA Kinya, POPY Kawser Akter, HIROTANI Makoto, SUGIMORI Hiroyuki, FUJIMA Noriyuki, YOSHIDA Atsushi, MINOWA Kazuyuki, SUZUKI Yuriko, SHIRATO Hiroki, 日本磁気共鳴医学会雑誌, 33, 1, 33, 34, 15 Feb. 2013
English - 当院における咀嚼筋腱・腱膜過形成症の臨床的検討
松下 和裕, 井上 農夫男, 箕輪 和行, 山口 泰彦, 佐藤 千晴, 佐藤 淳, 大井 一浩, 戸塚 靖則, 鄭 漢忠, 日本顎関節学会雑誌, 24, Suppl., 91, 91, Jul. 2012
(一社)日本顎関節学会, Japanese - 当施設におけるびまん性硬化性下顎骨骨髄炎の臨床的検討 臨床病態について
小野寺 麻記子, 山崎 裕, 秦 浩信, 足利 雄一, 大廣 洋一, 松沢 祐介, 小野 貢伸, 戸塚 靖則, 箕輪 和行, 滝波 修一, 進藤 正信, 野谷 健一, 北川 善政, 日本口腔外科学会雑誌, 57, Suppl., 137, 137, Sep. 2011
(公社)日本口腔外科学会, Japanese - 当施設におけるびまん性硬化性下顎骨骨髄炎の臨床的検討 治療効果について
足利 雄一, 山崎 裕, 秦 浩信, 小野寺 麻記子, 野谷 健一, 北川 善政, 松沢 祐介, 大廣 洋一, 小野 貢伸, 箕輪 和行, 滝波 修一, 進藤 正信, 戸塚 靖則, 日本口腔外科学会雑誌, 57, Suppl., 137, 137, Sep. 2011
(公社)日本口腔外科学会, Japanese - 耳下腺内に唾液貯留を疑う大きな嚢胞性病変を伴った若年型Sjoegren症候群の1例
小野寺麻記子, 野谷健一, 佐藤千晴, 北森正吾, 太子芳人, 箕輪和行, 水越孝典, 北川善政, 日本口腔診断学会雑誌, 23, 2, 374, 30 Oct. 2010
Japanese - 耳下腺内に唾液貯留を疑う大きな嚢胞性病変を伴った若年型Sjoegren症候群の1例
小野寺麻記子, 野谷健一, 佐藤千晴, 北森正吾, 太子芳人, 箕輪和行, 水越孝典, 北川善政, 日本口腔診断学会総会プログラム・抄録集, 23rd, 33, 2010
Japanese - クローズドロックに継発する前歯部開咬に関する臨床的検討
後藤田 章人, 山口 泰彦, 金子 知生, 岡田 和樹, 三上 紗季, 後藤田 幸, 松田 慎平, 佐藤 華織, 小松 孝雪, 梶井 貴史, 由川 哲也, 箕輪 和行, 井上 農夫男, 日本顎関節学会雑誌, 21, Suppl., 139, 139, Jul. 2009
(一社)日本顎関節学会, Japanese - Vacuum phenomenon in non-open fracture of the mandibular condyle: report of three cases
K. Minowa, N. Sakakibara, N. Inoue, K. Ohmori, T. Kuroshima, Y. Totsuka, Y. Kitagawa, M. Nakamura, DENTOMAXILLOFACIAL RADIOLOGY, 37, 6, 361, 364, Sep. 2008
English - Limitations of mouth opening, mainly caused by hyperplasia of the masseter muscle aponeurosis : A case report
SATOH Chiharu, INOUE Nobuo, YAMAGUCHI Taihiko, MINOWA Kazuyuki, SONOBE Masaharu, IIZUKA Tadashi, KANETA Hiroyuki, KITAGAWA Yoshimasa, 北海道歯学雑誌, 28, 1, 83, 88, 15 Jun. 2007
Japanese - CT and MRI findings of intraosseous schwannoma of the mandible: a case report
K. Minowa, N. Sakakibara, K. Yoshikawa, K. Ohmori, Y. Kitagawa, N. Inoue, Y. Totsuka, M. Nakamura, DENTOMAXILLOFACIAL RADIOLOGY, 36, 2, 113, 116, Feb. 2007
English - A case of adenoid cystic carcinoma originated from palate which showed dumbell-shaped expansion to the skull base by neural invasion
TAISHI YOSHIHITO, SUGIURA CHIHIRO, ABE TAKAHIRO, YOSHIKAWA KAZUHITO, NAGAI KOICHI, NOTANI KEN'ICHI, MINOWA KAZUYUKI, IIZUKA TADASHI, SHINDO MASANOBU, KITAGAWA YOSHIMASA, 日本口腔腫瘍学会誌, 18, 4, 189, 15 Dec. 2006
Japanese - A case of MALT lymphoma simultaneously occurring in the palate and the parotid gland
KATO TAKUMI, YAMAZAKI YUTAKA, SATO AKIRA, MINOWA KAZUYUKI, SHINDO MASANOBU, KITAGAWA YOSHIMASA, 日本口腔腫瘍学会誌, 18, 4, 190, 191, 15 Dec. 2006
Japanese - 顎関節のMRI:画像診断が,TMD(いわゆる顎関節症)患者の診断や治療に与える影響と,画像診断医と主治医による画像上の異常所見に関する解釈の違いについて
飯沼 英人, 箕輪 和行, 小林 一三, 防衛衛生, 53, 8, 165, 175, Aug. 2006
防衛衛生協会, Japanese - こう筋けん膜の過形成が主たる原因と考えられた開口障害の1例
佐藤千晴, 井上農夫男, 山口泰彦, 箕輪和行, 園部昌治, 北川善政, 日本顎関節学会雑誌, 18, 1, 95, 20 Apr. 2006
Japanese - 神経浸潤によりダンベル状に頭蓋底に進展した口蓋原発腺様のう胞癌の1例
太子芳仁, 杉浦千尋, 阿部貴洋, 吉川和人, 永井康一, 野谷健一, 箕輪和行, 飯塚正, 進藤正信, 北川善政, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 24th, 110, 2006
Japanese - 口蓋および耳下腺に発生したMALTリンパ腫の1例
加藤卓己, 山崎裕, 佐藤明, 箕輪和行, 進藤正信, 北川善政, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 24th, 112, 2006
Japanese - 「MRIで骨髄の血行の改善を経時的に評価できた下顎骨瀰慢性硬化性骨髄炎の１例」
笠原 和恵, 逸見 仁, 箕輪 和行, 三古谷 忠, 井上 農夫男, 戸塚 靖則, 『日本口腔外科学会雑誌』, 51, 12, 602, 605, 2005 - Evaluation of static bone cavities with CT and MRI
K Minowa, N Inoue, T Sawamura, A Matsuda, Y Totsuka, M Nakamura, DENTOMAXILLOFACIAL RADIOLOGY, 32, 1, 2, 7, Jan. 2003
English - A case of metastasis to the lateral lingual lymph nodes in a patient with a preoperative diagnosis of carcinoma of the tongue
OHIRO Yoichi, TEI Kanchu, KASHIWAZAKI Haruhiko, TOTSUKA Yasunori, IIZUKA Tadashi, MINOWA Kazuyuki, Japanese Journal of Oral and Maxillofacial Surgery, 48, 7, 359, 362, 20 Jul. 2002
A case of squamous cell carcinoma of the tongue with metastasis to the lateral lingual lymphnodes is reported. Preoperative computed tomography and magnetic resonance imaging revealed a mass0.5cm in diameter with heterogenous enhanced signal intensity outside of the left genioglossus muscle.Radical neck dissection, partial left glossectomy, and reconstruction with a forearm flap were performedin a pull-through manner after external radiation and chemotherapy. Histopathologically, the mass had alymph-node structure with small cancer nests at the margin., Japanese Society of Oral and Maxillofacial Surgeons, Japanese - Current head and neck imaging : changing metabolic imaging, PET from anatomical imaging
箕輪 和行, 澤村 強, 中村 太保, 北海道歯学雑誌, 22, 2, 234, 236, 15 Dec. 2001
Japanese - Regional differences of metabolism in human masseter muscle by two-dimensional P-31-chemical shift imaging
T Kanayama, K Minowa, N Inoue, T Yamaguchi, S Yoshida, T Kawasaki, JOURNAL OF DENTAL RESEARCH, 79, 1, 85, 89, Jan. 2000
English - Energy metabolism in the masseter muscle: A comparison of normal subjects and TMD patients using 31P-MRS
Kazuyuki Minowa, Nobuo Inoue, Taihiko Yamaguchi, Yasunori Totsuka, Tsuyoshi Sawamura, Keiichi Ohmori, Motoyasu Nakamura, Kazuyuki Minowa, Oral Radiology, 16, 1, 9, 15, 2000
Japanese Soc. for Oral and Maxillofacial Radiology, English - CT Angiography of the Head and Neck : A Report of 5 Cases
SAWAMURA Tsuyoshi, MINOWA Kazuyuki, ABE Satoru, OHMORI Keiichi, NAKAMURA Motoyasu, MIYASAKA Kazuo, Oral Radiol., 14, 2, 95, 105, 01 Dec. 1998
English - Comparison of magnetic resonance imaging and gross findings regarding masseter muscle aponeuroses in cadavers
K Minowa, N Inoue, Y Ashikaga, S Yoshida, Y Totsuka, M Nakamura, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 86, 3, 275, 279, Sep. 1998
English - Broken Fragment of the Mandibular Third Molar Tooth in the Floor of the Mouth
SAWAMURA Tsuyoshi, MINOWA Kazuyuki, ABE Satoru, OHMORI Keiichi, NAKAMURA Motoyasu, Oral Radiol., 14, 1, 29, 30, 01 Jun. 1998
English - Trial of dose reduction in mandibular CT
SAWAMURA Tsuyoshi, MINOWA Kazuyuki, ABE Satoru, OHMORI Keiichi, NAKAMURA Motoyasu, MIYASAKA Kazuo, 歯科放射線, 37, 50, 50, 10 Sep. 1997
Japanese - A method of reducing susceptibility artifacts in MRI of the head and neck region
K. Minowa, S. Abe, T. Sawamura, K. Obinata, K. Ohmori, M. Nakamura, Oral Radiology, 13, 1, 45, 49, 1997
English - Computed Tomography of the Impacted Teeth in the Maxilla : including image processing after scanning
SAWAMURA Tsuyoshi, MINOWA Kazuyuki, ABE Satoru, OHMORI Keiichi, NAKAMURA Motoyasu, MIYASAKA Kazuo, 歯科放射線, 36, 79, 79, 01 Sep. 1996
Japanese - MRI diagnosis of tongue tumors. Including dynamic enhanced MRI.:Including dynamic enhanced MRI
MINOWA Kazuyuki, ABE Satoru, OHMORI Keiichi, HOSOKAWA Yoichirou, YAMASAKI Michio, HIRANO Masayasu, Journal of Oral Surgery Society of Japan, 38, 6, 973, 981, 1992
MRI studies were performed on 29 patients with tongue tumors.26 cases were fresh, others were recurrent.Signal intensity of tongue tumor was not characteristic and specific, and it was a low-iso signal on T1 weighted image (WI), heterogeneously iso-high signal intensity on T2 WI, heterogeneous enhancement on gadolinium-DTPA enhanced image compared to muscle signal intensity.
In 3 of 29 patients, the tongue tumor invaded to the mandible.With regard to the grasping tumor invasion to the mandible, the STIR method was superior to T1, T2 WI of the spin echo method.Dynamic enhanced MR images were performed in 6 of 29 patients. Dynamic.change of signal intensity after gadolinium-DTPA administeration were assessed with fast low angle shot imaging.
On dynamic study at about 20 seconds after gadolinium-DTPA injection, the first signal intensity in the periphery of the tumor gradually began to increase.Maximum signal intensity of the tumor showed at about 70 seconds after gadolinium-DTPA injection. In search from 0 to 5 minutes, after the tongue tumor showed maximum signal intensity, its signal maintain the maximum.Necroic and peritumorous edema showed a significantly lower and more gradual increase in signal intensity than adjacent neoplastic tissue on dynamic enhanced MRI., Japanese Society of Oral and Maxillofacial Surgeons, Japanese - MRI diagnosis of tongue fumors-including dynamic enhanced MRI
Kazuyuki MINOWA, Satoru ABE, Keiichi OHMORI, Yoichirou HOSOKAWA, Michio YAMASAKI, Masayasu HIRANO, Japan Journal of oral maxillo facial Surgery, 38, 6, 973, 981, 1992
MRI studies were performed on 29 patients with tongue tumors.26 cases were fresh, others were recurrent.Signal intensity of tongue tumor was not characteristic and specific, and it was a low-iso signal on T1 weighted image (WI), heterogeneously iso-high signal intensity on T2 WI, heterogeneous enhancement on gadolinium-DTPA enhanced image compared to muscle signal intensity.
In 3 of 29 patients, the tongue tumor invaded to the mandible.With regard to the grasping tumor invasion to the mandible, the STIR method was superior to T1, T2 WI of the spin echo method.Dynamic enhanced MR images were performed in 6 of 29 patients. Dynamic.change of signal intensity after gadolinium-DTPA administeration were assessed with fast low angle shot imaging.
On dynamic study at about 20 seconds after gadolinium-DTPA injection, the first signal intensity in the periphery of the tumor gradually began to increase.Maximum signal intensity of the tumor showed at about 70 seconds after gadolinium-DTPA injection. In search from 0 to 5 minutes, after the tongue tumor showed maximum signal intensity, its signal maintain the maximum.Necroic and peritumorous edema showed a significantly lower and more gradual increase in signal intensity than adjacent neoplastic tissue on dynamic enhanced MRI., Japanese Society of Oral and Maxillofacial Surgeons, Japanese - MRI diagnosis of cavernous hemangioma at head and neck region.
MINOWA Kazuyuki, OHMORI Keiichi, HOSOKAWA Yoichiro, YAMASAKI Michio, HIRANO Masayasu, Journal of Oral Surgery Society of Japan, 37, 11, 1802, 1809, 1991
Cavernous hemangioma is common in the head and neck region, and pathologically cavernous hemangioma characterized by small feeding arteries and large blood pools.
Angiography and computed tomography have not demonstrated the whole extension of these lesions. 9 patients with cavernous hemangioma were evaluated with magnetic resonance imaging in this study. MRI could clearly demonstrate cavernous hemangiomas with good contrast to normal tissues.
Cavernous hemangiomas showed losv-iso signal intensity compared to the muscle on the Ti weighted image and isu-high signal intensity on T2. All cases did not show a flow void on the proton density image that is most sensitive to flow, and were enhanced by Gd-DTPA.
Especially, T2 weighted and Gd-DTPA enhanced images were useful to demonstrate these lesions.
Intramuscular cavernous hemangiomas in the head and neck region were characterized by local muscle atrophy and septum formation., Japanese Society of Oral and Maxillofacial Surgeons, Japanese - Efficacy of Gadolinium-DTPA enhanced MRI to the tumors in paranasal sinuses
Kazuyuki MINOWA, Satoru ABE, Yoichirou HOSOKAWA, Keiichi OHMORI, Michio YAMASAKI, Masayasu HIRANO, Japan Journal of oral maxillo facial surgery., 37, 12, 2054, 2059, 1991
We examined whether magnetic resonance imagings (NIRI) after gadolinium-DTPA administration were clinically more useful than nonenhanced MRI in 17 patients with paranasal sinus noeplasm. Seventeen patients underwent MR I both with and without gadolinium-DTPA, and CT. Six of the seventeen cases demonstrated coexisting neoplasm and mucoceles, polyps. Though nonenhanced MRI enabled correct differentiation of 3 of these 6 lesions, gadolinium-enhanced MRI enabled correct differentiation of all 6 lesions.
We concluded that gadolinium-enhanced MRI was useful for differentiating neoplasms and mucoceles or polyps in the paranasal sinuses., Japanese Society of Oral and Maxillofacial Surgeons, Japanese - MRI diagnosis of Cavernous hemmgioma at head and Neck region
Kazuyuki MINOWA, Keiichi OHMORI, Yoichiro HOSOKAWA, Michio YAMASAKI, Masayasu HIRANO, Japan Journal of oral maxillo facial surgery, 37, 11, 1802, 1809, 1991
Cavernous hemangioma is common in the head and neck region, and pathologically cavernous hemangioma characterized by small feeding arteries and large blood pools.
Angiography and computed tomography have not demonstrated the whole extension of these lesions. 9 patients with cavernous hemangioma were evaluated with magnetic resonance imaging in this study. MRI could clearly demonstrate cavernous hemangiomas with good contrast to normal tissues.
Cavernous hemangiomas showed losv-iso signal intensity compared to the muscle on the Ti weighted image and isu-high signal intensity on T2. All cases did not show a flow void on the proton density image that is most sensitive to flow, and were enhanced by Gd-DTPA.
Especially, T2 weighted and Gd-DTPA enhanced images were useful to demonstrate these lesions.
Intramuscular cavernous hemangiomas in the head and neck region were characterized by local muscle atrophy and septum formation., Japanese Society of Oral and Maxillofacial Surgeons, Japanese - Effectiveness of time shortening in sialoscintigraphy. With special reference to Sjoegren syndrome.
滝波 修一, 鈴木 一史, 箕輪 和行, 金子 正範, 山崎 岐男, Shika Hoshasen, 28, 3, 344, 347, 1988
Japanese Society for Oral and Maxillofacial Radiology, Japanese
Research Themes
- 歯科的身元確認を支援する包括的歯科材料データベースの構築-災害時応用を目指して
科学研究費助成事業
Apr. 2024 - Mar. 2026
竹内明子, 的場光太郎, 神 茂樹, 箕輪和行
基盤研究(C), 24K13384 - 歯周病細菌の脳への移行トレース
科学研究費助成事業
01 Apr. 2022 - 31 Mar. 2025
箕輪 和行, 亀田 浩之, 長谷部 晃
日本学術振興会, 基盤研究(C), 北海道大学, 22K10333 - 全身主要血管壁内における歯周病原性菌の存在分布ー脳血管障害による死亡例をもとに
科学研究費助成事業
01 Apr. 2020 - 31 Mar. 2023
竹内 明子, 的場 光太郎, 箕輪 和行, 兵頭 秀樹, 亀田 浩之, 長谷部 晃
研究期間２年目では、ご遺体（法医解剖体）における死後CT画像取得時に、全身大血管（大脳動脈、頚動脈、胸部大動脈、腹部大動脈）における壁肥厚やプラークによる血管狭窄に対する画像的検索を進めており、これらの症例数は累計で18件となりました。
検体採取を行ったそれぞれの症例において画像的検索と法医解剖所見を比較することで、歯周病細菌の存在分布検証に用いる検体（主要血管壁）の採取部位をそれぞれ決定しました。また、採取した血管壁を用いて、凍結切片の作成により、病理学的検索の可能性を模索し、免疫染色による歯周病菌の同定（存在分布の確認）についても追加の検討を行っています。
予備実験において、死後CT画像にて血管壁に石灰化が見られる場合、DNA採取が困難である場合があり、血管壁の石灰化の度合いに対して、死後CT画像上でのスコア化を追加検討しています。
また、法医解剖体の口腔内所見採取時に、歯周病進行状況、残存歯数、歯科治療痕等のデータ収集をさらに進めています。検体数の増加により、前年度に取得した歯周ポケット検査による歯周病進行度のスコアに変更が生じたため、再度検討を行っています。検体採取については２年目も順調に進んでいますが、検体数の増加にともない、検体の口腔内所見（残存歯数や歯科治療所見）が多様に見られ、また、高齢のご遺体（解剖体）では、残存歯数が少ない場合があり、初年度に採取した口腔内所見によるスコア化に関して、調整が必要となっています。
日本学術振興会, 基盤研究(C), 北海道大学, 20K10287 - Evaluation of oral pathology that can cause sudden death - by Autopsy imaging
Grants-in-Aid for Scientific Research
01 Apr. 2018 - 31 Mar. 2022
minowa kazuyuki
This study sought to clarify the relationship between oral air space volume and obstructive sleep apnea syndrome (OSAS) onset, which is influenced by multiple factors, such as jawbone, dentition morphology, and oral soft-tissue volume. (1)50 subjects from deceased cases were divided into two groups: OSAS (25 subjects) and controls (25 subjects). (2) 33 subjects from clinical cases were divided into two groups: OSAS (9 subjects) and controls (24 subjects). In all cases, the CT images of the facial region were obtained, and four parameters of oral area volume were analyzed in deceased and clinical cases, and comparisons and analyses were performed between OSAS and control cases. In deceased cases, oral soft-tissue volume (OSV), oral air-space volume (OAV), and the ratio of OAV to OSV (%air) showed a significant correlation. In clinical cases, OAV and %air showed a significant correlation. Furthermore, the evaluation including the pharyngeal area were similar to this results.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 18K09872 - Relations between occlusal discomfort syndrome and threshold of oral sensory - a quantitative magnetoencephalographic study by statistical Parametric Mapping(SPM) analysis-
Grants-in-Aid for Scientific Research
01 Apr. 2015 - 31 Mar. 2019
Satoh Kaoru
We recorded brain activity stimulating periodontium with MEG to verified part of cerebrum and analyzed frequency using SPM8 method. As a result, the power value of alpha waves during rest and closing eyes was reduced by continuous mechanical stimulation on the periodontium. SPM analysis revealed that the activities located in the centriciput- occiput region. But the difference of region was noticed with and without stimulation. On the other hand, it required a study of correlation between power value and VAS.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 15K11189 - Development of MR microscope for the squamous carcinoma in the oral cavity
Grants-in-Aid for Scientific Research
01 Apr. 2013 - 31 Mar. 2017
Minowa Kazuyuki
The aim of our study is to develop the MR microscope that non-invasively will be able to visualize pathological information of the squamous cell carcinoma in the oral cavity by Q space image technique belonging to the diffusion weighted images. The parameter of the Q space imaging technique was established for this study. The comparison between the parameter of the Q space imaging and specimen of the squamous cell carcinoma in the oral cavity, also between the parameter of the Q space imaging and routine diagnostic image for the oral cancer were evaluated.
The correlations between some of the parameters in the Q space imaging and cell growth factor, routine diagnostic image for the oral cavity cancer were obtained.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 25462910 - Relations between occlusal discomfort and adaptability to oral appliances - a quantitative magnetoencephalographic study -
Grants-in-Aid for Scientific Research
28 Apr. 2011 - 31 Mar. 2015
SATOH Kaoru, YAMAGUCHI Taihiko, MAEZAWA Hitoshi, MINOWA Kazuyuki, OKADA Kazuki
We analyzed brain activity with MEG to establish a method for objective evaluation of correlation between discomfort and intensity of occlusal contacts. Oral somatosensory was stimulated. As a result, power value of alpha waves during rest and closing eyes was reduced by continuous mechanical stimulation on the periodontal membrane. The activity was generated in the centriciput- occiput region. It was suggested that this method was effective to cause discomfort on periodontal membrane.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 23592825 - The evaluation of therapeutic effect in head and neck tumor by 31P-CSIon 3tesla MR apparatus
Grants-in-Aid for Scientific Research
2009 - 2011
MINOWA Kazuyuki
31P-CSI was obtained in the head and neck region by CSI on 3T MR apparatus. The experiment data in normal volunteer resulted the sequence of 31P-CSI was TR/TE:4500/0.1msec, acquisition time:32, and interesting volume was more than 5.5cm^3. The half width on 31P-CSI was 0.5-1.1ppm in the head and neck region.
31P-CSI in the skull base and pharyngeal surface region was not able to obtain due to susceptibility artifact.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 21592382 - Studies on effect of physical therapies and occlusal splints on temporomandibular disorders using blood flow analyses of masseter muscles
Grants-in-Aid for Scientific Research
2002 - 2003
YAMAGUCHI Taihiko, TOTSUKA Yasunori, SATOH Kaoru, KOMATSU Kosetsu, MINOWA Kazuyuki, INOUE Nobuo
The purpose of this study was to clarify whether physical therapies and occlusal splints are effective against muscle fatigue of temporomandibular disorders (TMD) patients from the point of view of blood flow state.
Blood flow of masseter muscles were measured using 3-wave-length near-infrared spectroscopy, and the blood flow parameters were total hemoglobin volume (THb), oxygenated hemoglobin volume (OXHb), deoxygenated hemoglobin volume (deOXHb), and oxygen saturation level (StO2). Subjects for the physical therapies were healthy subjects with no history of muscle pain in the masticatory system, while subjects for the splint therapy were TMD patients with masticatory muscle symptoms who used stabilization splints. The physical therapies applied were 20-minite hot pack and 30-minite myo-monitor.
1)THb,OXHb and StO2 after the hot pack application were significantly larger than those during resting. The deOXHb showed no significant difference between the values before and after the hot pack application. The results suggest that the blood flow state of human masseter muscles can be influenced by a hot pack, and that the effect of hot pack therapy is to increase regional blood volume and that it creates the advantageous conditions for aerobic energy metabolism.
2)There was no no significant difference between the values before and after myo-monitor application in all parameters of blood flow.
3)During resting, mean values of StO2 with the splint were significantly larger than those without the splint During and after clenching, THb with the splint was significantly larger than that without the splint. The results suggest that the blood flow of masseter muscles can be influenced by wearing stabilization splints in the short term. However, effect of longtime using of splints is still unknown. Further studies on longitudinal change in blood flow stale of masticatory muscles in wearing splints are needed.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), HOKKAIDO UNIVERSITY, 14571834 - A study on the influences of regional tissue blood flow volume on energy metabolism in deep and superficial part of masseter muscles
Grants-in-Aid for Scientific Research
1999 - 2000
INOUE Nobuo, MINOWA Kazuyuki, YAMAGUCHI Taihiko, TOTSUKA Yasunori
The purpose of this study was to clarify the the influences of regional tissue blood flow volume (RTVF volume) on energy metabolism in deep and superficial part of masseter muscle (Mm)
1. Establishment of 31P-Chemical Shift Imaging (CSI) for human Mm.
We have succeeded in analyzing energy metabolism in both deep and superficial part of Mm. It has become clear that the superficial part of Mm contains more phosphocreatine (PCr) than deep part. This result suggests that deep and superficial part of Mm need to be measured separately in analyzing energy metabolism.
2. Establishment of analyzing methods of RTVF volume.
A three wavelength spectrophotometric method were used. As the parameters of RTVF volume, total hemoglobin (Hb) volume, and ratio and period of change in Hb were selected. It was demonstrated that RTVF volume in Mm changes as head and/or upper half of body lean, and that we need to keep head and body position stable.
3. Establishment of condition for exercise task.
Among several condition for exercise task such as maximal clenching, gum chewing and so on, 10 kgf clenching for 20 sec. was considered to be adequate.
4. Measurements in healthy people and patients with temporomandibular disorders (TMD).
As for the energy metabolism, PCr in Mm of TMD patients was lower than that of healthy people. In other words, it was suggested that energy level of Mm in TMD patients was lower than that of healthy people. However, we could not obtain obvious conclusion concerning RTVF volume because of wide variation of the data. Therefore, to diminish the influence of the wide variation and to confirm the relation between energy metabolism and RTVF volume, we need to gather more data in further studies by using the analyzing methods established in this study.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), HOKKAIDO UNIVERSITY, 11671970 - A study on the influences of changes of regional tissue blood flow volume on energy metabolism in masticatory muscles
Grants-in-Aid for Scientific Research
1998 - 1999
YAMAGUCHI Taihiko, KOMATSU Kosetsu, INOUE Nobuo, TOTSUYA Yasunori, SATOH Kaoru, MINOWA Kazuyuki
In order to clarify the influences of chronic decrease in blood flow volume on energy metabolism in masticatory muscles, we tried to establish the method for obtaining 31P-spectra by using NMR, and tried to make the the wister rat model in which the blood flow volume of the gastrocneminus muscles and the soleus muscles chronically continued to decrease with bound dominant artery. As the parameters of regional tissue blood flow volume, oxygen saturation level of blood (StO2) and total hemoglobin (Hb) volume were measured using a three wavelength spectrophotometric method.
The results were as follows;
1. Using a 7T NMR and a surface coil (25mm diameter), we obtained the 31P-spectra of ATP sample, and we were able to detect peaks of α, β, γ-ATP. However, the 31P-spectra of rat muscles were not obtained clearly because of noise from surrounding tissues. This problem is expected to be solved by improvement in program of control system of the NMR.
2. We obtained precise reproduciblity in measurement of StO2 and Hb volume, when we fixed both the probe of measuring apparatus and the leg of rats using devices which we made for fixation appropriately.
3. Just after binding of the artery, the value of StO2 and total Hb volume declined by about 30% and 70%, respectively. These levels continued one or two months after binding. Therefore, it was suggested that we could make the relatively chronic model in which the blood flow volume of the gastrocneminus muscle and the soleus muscles decreased obviously.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), HOKKAIDO UNIVERSITY, 10671811 - 顎関節症の^<31>P,^1H-MRSおよびfMRIによる筋肉,脳代謝からの総合的研究
科学研究費助成事業
1997 - 1998
箕輪 和行
^<31>P-CSI(^<31>P-ChemicalShiftImaging)^<31>P-CSIでは新たに設定したパラメータ(TR:330msec,flipangle:51degrees,acquisition:9,matrixsize:16×16,FOV:320mm,検査時間12分40秒) で、正常者咬筋の浅層と深層それぞれ腱膜を指標として分離し、各層からのスペクトルを得ることに成功した。その結果、咬筋の浅層と深層ではフォスフォクレアチンの存在量に有意な差が見られ、筋線維の違いによる代謝の違いが示唆された。さらに、内側翼突筋、外側翼突筋、側頭筋からもスペクトルを得ることに成功した。^<31>P-CSIにて内側翼突筋は咬筋浅層とフォスフォクレアチンの存在量で有意な差は見られず、両者は同様の代謝をしている可能性が示唆された。しかし、外側翼突筋、側頭筋からのスペクトルは筋自体の体積が小さく、周囲組織からの信号の混入が多く、撮像パラメータの検討が必要であると思われた。^1H-MRSshinglevoxcel (size;1×2×4cm:8ml)を用いて咬筋全体からスペクトルを得ることに成功した。パラメータは新たに以下のように設定した。TR:2000msec,TE:135msec,acquisition:256,FOV:300mm,検査時間10分である。voxcel内の半値幅は約0.2ppmであった。安静時における正常者の咬筋からは乳酸は検出されなかったが、最大噛みしめの運動を負荷した場合、僅かな乳酸の二峰性のピークが認められた。時間とともに、乳酸のピークが減少する傾向にあり、血流との関係が問題となるものと考えられた。funcionalMRI咀嚼の運動として用いたのは運動により頭部のずれが少ない中心咬合位での軽いタッピングである。運動を負荷すると負荷にに伴って咀嚼の一次運動野の信号が3〜5%上昇した。運動負荷に伴って、咀嚼運動野の信号が全体的に上昇する傾向が見られた。
日本学術振興会, 奨励研究(A), 北海道大学, 09771561 - An investigation of the mechanism of muscle contracture in TMD patients using analysis of muscular energy metabolism
Grants-in-Aid for Scientific Research
1996 - 1997
YAMAGUCHI Taihiko, SATOH Kaoru, MINOWA Kazuyuki, KOMATSU Kosetsu, INOUE Nobuo, TOTSUKA Yasunori
The purpose of this study was to investigate the mechanism of the masseter muscle contracture which caused resistance to stretch of jaw.
1.In clinical examinations, most of the TMD patients with contracture had little muscular pain during rest, jaw closing, and biting. During maximal jaw opening, they felt hard resisting power of their masseter muscles, but did not feel strong pain. The pain during maximal jaw opening was mostly slight and dull. These characteristics were different from characteristics of TMD patients with typical muscular pain.
2.In EMG examinations, abnormal pattern of EMG activity was not found apparently during rest jaw closing and biting. However, the EMG during jaw opening showed hyperactivity of masseter muscles. These two results suggest that the mechanism of masseter muscle contracture will be different from that of muscular pain. In other words, it is likely that the masseter muscle contracture is not necessarily due to the hyperactivity of masseter muscles during rest, jaw closing and biting.
3.In analysis of muscular energy metabolism (31P-magnetic resonance spectroscopy) , phosphocreatine (PC_r) /beta-ATP values of the patients with contracture was lower than normal controls. This result suggested that the PC_r would be consumed and the masseter muscles would be on a low level of latent energy. Therefore the improvement of peripherad blood flow using physical treatment such as massage of muscles will be necessary for the patients with contracture.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), HOKKAIDO UNIVERSITY, 08672222 - ^1-MRSによるヒト咬筋内の乳酸の検出
科学研究費助成事業
1996 - 1996
箕輪 和行
今回は顎関節症患者の咬筋内の乳酸を測定する前段階として、正常者ヒト咬筋内の乳酸を測定するための1H-MRSのプログラムの開発を目的として実験を行った。
対象は正常ボランティアの咬筋とし、使用装置は北海道大学医学部附属病院所有のMR装置、Seimens社製のVISION(静磁場強度1.5tesla)とMRIおよびMRS両用のhead coilを使用した。まずはガントリ-の周囲にある12個のコイルを調製して、コイル全体の磁場を均一にするプログラムを作成した。さらに、T1強調像にて撮像し、咬筋の位置を3次元的に確認し、周囲の脂肪組織が関心領域内に入らないように咬筋内に関心領域を設定し、この関心領域内の磁場を均一にするように12個のコイルを調整した。関心領域は咬筋の形状を考え直方体とし、被験者により多少の変形を加え、その体積は約10ml前後であった。乳酸の検出に優れているといわれているspin echo法のSVS (single voxcel spectroscopy)を使用し、信号を収集場合の条件はTR=2000msec, TE=270msec,積算回数=300回とした。信号収集時間は6分であった。
結果、正常者の咬筋からは安静時には、乳酸のピークは認められなかった。しかしながら、可能な限り最大噛みしめを持続させた場合にのみ、乳腺のピークが得られた。
日本学術振興会, 奨励研究(A), 北海道大学, 08771633 - The relationship between electromyograph and energy metabolism in masseter mucles of TMD patients
Grants-in-Aid for Scientific Research
1994 - 1995
YAMAGUCHI Taihiko, KOMATU Kosetu, UEDA Yasuo, MINOWA Kazuyuki, INOUE Nobuo, TOTSUKA Yasunori
The purpose of this study was to verify the relationship between electromyograph (EMG) and energy metabolism in masseter mucles of TMD patients. The EMG data were compared with energy metabolism data analyzed by 31P-MRS (Magnetic Resonance Spectroscopy).
The results were as follows ;
1. Before and after fatigue-loading, the power spectral analysis of EMG showed the similar tendency to 31P-MRS analysis. It was suggested that the power spectral analysis of EMG might reveal the state of muscle fatigue and energy metabolism in masseter muscle.
2. In the chewing rhythm analysis by EMG,the mean of CV (coefficiency of variation) in TMD patients suffering from pain and contracture of masseter muscles was higher than that in normal subjects. But there was little correlation between the result of CV analysis and that of 31P-MRS analysis.
3. The mean of interval/cycle time ratio in TMD patients suffering from pain and contracture of masseter muscles was higher than that in normal subjects. The result of interval/cycle time analysis was correlative with the result of energy metabolism analysis by 31P-MRS.
4. In one TMD patient, 31P-MRS analysis showed improvement of muscle fatigue after treatments, but interval/cycle time ratio was not changed evidently. In this patient, the ratio before treatment was almost in nomal range, because the border of burst was not obvious and the duration of burst was enlarged abnomally. After treatment the border of burst became clear and the burst shape became normal. This results suggest that the analysis of interval/cycle time ratio must be done together with the burst shape analysis.
Japan Society for the Promotion of Science, Grant-in-Aid for General Scientific Research (C), HOKKAIDO UNIVERSITY, 06671939 - 31P-MRSを用いた領域選択法によるヒト咀嚼筋群のエネルギー代謝の把握
科学研究費助成事業
1994 - 1994
箕輪 和行
ヒト咬筋に対する表面コイル法による31P-スペクトロスコピーの方法を本研究代表者は平成4年度の科学研究費を使用して確立し、その成果を顎関節学会誌(P14-25 vol6 No.2 1994)に発表した。今回はさらに領域選択法、ISIS(image selected in vivo spectroscopy)法を使用し、より正確にヒト咀嚼筋群の個々のスペクトルを得ようとする試みを行った。対象被験者は正常ボランティア10名であり、使用機種は静磁場強度1.5teslaの臨床機種(MAGNETOM)を使用した。
結果および結論
1.領域選択法について
理論的には信号収集領域を直方体とすることは可能であるが、実際にはその領域内での磁場の均一性が得られず、領域設定は立方体のみ可能となった。したがって、咀嚼筋群のような直方体の形状を有する筋の場合、信号収集領域が筋全体を含むためには不可能となった。
2.ISIS法は信号収集領域が小さく、表面コイル法に比べ信号が弱く、そのため加算回数を512、1024回とする必要があり検査時間もそれぞれ約26分、52分となった。
3.バックグランドノイズにスペクトルが埋没することが多く、より良いスペクトルを得るためには被験者の強力がかなり必要な検査であった。
4.実際スペクトルは10例中1例の咬筋から得られた。その他の、内外側翼突筋、側頭筋は体積がかなり小さく、形態も複雑であり、ISIS法では選択領域の磁場の均一性が確保できずスペクトルは得られなかった。今後、対象筋肉の形態に合わせた領域の設定、領域選択法の確立がなされて初めて安定したISIS法によるスペクトルが得られると思われた。
日本学術振興会, 奨励研究(A), 北海道大学, 06771655 - 頭頸部画像診断
Competitive research funding - Radiological diagnosis in head and Neck
Competitive research funding
