Jun. 2025, AsCNP Science Award 2025, Clinical Science Award　　　　　　　　　　　　　　　
Takahiro A. Kato

Jun. 2023, 第119回日本精神神経学会学術総会, PCN Reviewer Awards　　　　　　　　　　　　　　　
加藤隆弘

Mar. 2023, 日本MOT学会第14回年次研究発表会, ペストペーパーアワード金賞　　　　　　　　　　　　　　　
メタバース内のアバター活用による孤立予防に関する調査研究
林裕子, 加藤隆弘

Jun. 2022, 日本精神分析協会, 土居健郎精神分析奨励賞　　　　　　　　　　　　　　　

Sep. 2020, 第116回日本精神神経学会学術総会, PCN Reviewer Awards　　　　　　　　　　　　　　　

Feb. 2020, 公益財団法人 島津科学技術振興財団, 2019年度 島津奨励賞　　　　　　　　　　　　　　　
「気分障害の血液メタロボーム解析による客観的診断法の創出」

Sep. 2018, 第40回日本生物学的精神医学会, 第4回若手研究者育成プログラム・最優秀奨励賞　　　　　　　　　　　　　　　
「脳内免疫細胞ミクログリアに着目した精神疾患のトランスレーショナル研究」

Sep. 2014, 第36回日本生物学的精神医学会・第3期若手研究者育成プログラム, 奨励賞　　　　　　　　　　　　　　　
Japan

Feb. 2013, 第9回ドパミン・パーシャル・アゴニスト（DPA）研究会, 優秀賞　　　　　　　　　　　　　　　
第9回ドパミン・パーシャル・アゴニスト（DPA）研究会・基礎研究部門にて受賞。

Nov. 2012, 公益財団法人ファイザーヘルスリサーチ振興財団, 第21回(平成24年度)国際研究助成賞　　　　　　　　　　　　　　　
第21回平成24年度公益財団法人ファイザーヘルスリサーチ振興財団・国際研究助成「国際調査票開発に基づく現代うつ病と社会的ひきこもりの実態調査」, 副賞300万円

Nov. 2012, 公益財団法人 武田科学振興財団, 2012年度 医学系研究奨励賞　　　　　　　　　　　　　　　
公益財団法人 武田科学振興財団 [2012年度 医学系研究奨励]「精神疾患患者由来iN神経を用いた神経－グリア相互作用の解明」, 副賞300万円

May 2012, 日本精神神経学会, 平成24年度 精神医療奨励賞受賞（メンタルヘルス・ファーストエイド・ジャパン(MHFA-J)チーム）　　　　　　　　　　　　　　　
Japan

Oct. 2011, 日本精神神経学会, 平成23年度 若手派遣助成賞（シンポジウム組織部門：世界精神医学会2010（北京大会））　　　　　　　　　　　　　　　
シンポジウム組織部門：世界精神医学会2010（北京大会）における国際シンポジウムのオーガナイズに際して。

Jun. 2009, the World Federation of Societies of Biological Psychiatry, Young Scientists Award from the World Federation of Societies of Biological Psychiatry, 9th World Congress of Biological Psychiatry (Paris, France)　　　　　　　　　　　　　　　
France

Nov. 2008, Pacific Rim College of Psychiatry, Pacific Rim College of Psychiatry − Schizophrenia Research First Award (Tokyo)　　　　　　　　　　　　　　　
Japan

May 2008, 日本精神神経学会, 日本精神神経学会 平成20年度精神医学奨励賞 (第104回日本精神神経学会総会, 東京)　　　　　　　　　　　　　　　
Japan

Apr. 2007, World Psychiatric Association, Travel Award: World Psychiatric Association Regional Meeting 2007 (Seoul, South Korea)　　　　　　　　　　　　　　　
Korea, Republic of

Urban mental health, hikikomori, and modern-Type depression.
Takahiro A Kato, Umberto Volpe, Norman Sartorius
Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater, 01 Dec. 2025, [International Magazine]
English, Scientific journal, Urbanization and digitalization are reshaping the landscape of mental health, contributing to increased social isolation, stress, and the emergence of novel psychopathologies. This paper explores the impact of urbanization on mental health, with a particular focus on two contemporary phenomena: "Hikikomori" (severe social withdrawal) and "Modern-Type Depression (MTD)." These conditions highlight the need for psychiatrists to adopt innovative, interdisciplinary approaches that integrate sociocultural understanding and technological advancements. By utilizing digital tools such as metaverse and communication robots, mental healthcare can evolve to effectively address these emerging challenges. Moreover, following the COVID-19 pandemic, hikikomori may hold the potential to evolve from a pathological condition into a new lifestyle for human beings.

Psychosis induced by invocation presenting as possession state: A case of Kitousei-Seishinbyo still emerging in modern Japan.
Fumiya Miyano, Nobuyuki Mitsui, Yutaka Fujii, Takahiro A Kato
PCN reports : psychiatry and clinical neurosciences, 4, 4, e70227, Dec. 2025, [International Magazine]
English, Scientific journal, BACKGROUND: Kitousei-Seishinbyo, or psychosis induced by invocation, was first described by Morita in 1915 as a culture-bound syndrome characterized by possession-like states and personality transformation triggered by prayer or spiritual practices. New psychosocial triggers (e.g., self-improvement seminars, emerging religious groups) have been identified. However, reports of possession-related episodes have become extremely rare. Diagnostic confusion with dissociative identity disorder or other specified dissociative disorders persists. CASE PRESENTATION: A woman in her 50s, with no prior psychiatric history, developed acute possession-like symptoms after visiting a fortune-teller. She was told her misfortune was caused by the spirit of her aborted child. Soon after, she entered trance states, spoke in altered voices (male and childlike), and exhibited personality changes, agitation, and dangerous behaviors, leading to involuntary admission. On evaluation, laboratory tests, electroencephalogram (EEG), and imaging were unremarkable. During hospitalization, she exhibited mutism, rigidity, temporary auditory hallucinations, and somatic complaints such as heaviness and dizziness, which fluctuated depending on spiritual contact. Retrospective review revealed significant psychosocial stressors, including marital discord, caregiving burden, and strained family relationships. Management involved family psychoeducation, occupational therapy, and low-dose psychotropics (tandospirone and zolpidem). Her symptoms gradually stabilized, and she voluntarily discontinued spiritual practices. She was discharged after 62 days with improved family dynamics and sustained recovery. CONCLUSION: This case illustrates a present-day example of Kitousei-Seishinbyo triggered by encountering a fortune-teller. Improvement was achieved through combined psychosocial interventions and low-dose pharmacotherapy.

Association between higher cerebrospinal fluid levels of phosphorylated tau and reduced depressive symptoms in patients with cognitive decline.
Takashi Ozaki, Naoki Hashimoto, Hisashi Narita, Niki Udo, Shizuka Mito, Shin Nakagawa, Ichiro Kusumi, Takahiro A Kato
PCN reports : psychiatry and clinical neurosciences, 4, 4, e70228, Dec. 2025, [International Magazine]
English, Scientific journal, AIM: In individuals with cognitive decline, depressive symptoms can affect disease progression and quality of life. One factor that may be associated with depressive symptoms is phosphorylated tau (p-tau). However, the association between p-tau and depressive symptoms remains controversial. The present study examined the relationship between p-tau levels and depressive symptoms not only in terms of total scale scores of the 15-item Geriatric Depression Scale (GDS-15) but also at the item level. METHODS: We conducted a cross-sectional survey of patients (n = 88) with mild cognitive impairment due to Alzheimer's disease (AD) or with AD dementia (ADD), who were strictly diagnosed by a board of psychiatrists and neurologists from Hokkaido University Hospital. All patients underwent lumbar puncture to obtain cerebrospinal fluid for the p-tau assessment. We first investigated the association between p-tau level and GDS-15 total score. Next, we compared the p-tau levels for each item using the GDS-15 with binary responses "none (0)" or "present (1)." RESULTS: Multivariable regression analysis revealed that higher levels of p-tau were significantly associated with lower GDS-15 total scores (standardized coefficient [95% confidence interval] = -0.28, [-0.48, -0.09]). Furthermore, patients with higher p-tau levels were less likely to have symptoms of GDS-15 Items 2 (Dropped interests) (p < 0.001) and 14 (Hopeless) (p = 0.0030). CONCLUSION: Our findings suggest an association between p-tau accumulation and reduced depressive symptoms. However, future longitudinal studies are required to confirm whether p-tau may be a predictive factor for depressive symptoms.

Leveraging machine learning to uncover the hidden links between trusting behavior and biological markers.
Zimu Cao, Daiki Setoyama, Monica Natsumi Daudelin, Toshio Matsushima, Yuichiro Yada, Motoki Watabe, Takatoshi Hikida, Takahiro A Kato, Honda Naoki
Dialogues in clinical neuroscience, 27, 1, 201, 215, Dec. 2025, [International Magazine]
English, Scientific journal, Understanding the decision-making mechanisms underlying trust is essential, particularly for individuals with mental disorders who often experience difficulties in forming interpersonal trust. In this study, we aimed to explore biomarkers associated with trust-based decision-making through quantitative analysis. However, quantifying internal decision-making processes is challenging, as they are not directly observable. To address this, we developed a machine learning method based on a Bayesian hierarchical model to quantitatively infer latent decision-making parameters from behavioural data collected during a trust game. Applying this method to data from patients with major depressive disorder (MDD) and healthy controls (HCs), we estimated individualised model parameters that regulate trust-related decisions. The model successfully predicted participants' behaviours in the task. Although no significant group-level differences were observed in the estimated parameters between the MDD and HC groups, we uncovered hidden links between trust-related decision-making processes and specific blood biomarkers. Notably, metabolites such as 5-aminolevulinic acid, acetylcarnitine, and 2-aminobutyric acid were significantly associated with individual differences in trusting behaviour. These findings provide valuable insight into the biological basis of trust-based decision-making. They also offer a novel framework for integrating behavioural modelling with biomarker discovery, potentially informing the development of targeted interventions to enhance social functioning and overall well-being.

The characteristics of modern-type depression and its relevance in clinical practice
Umberto Volpe, Laura Orsolini, Takahiro Kato
Current Opinion in Psychiatry, 39, 1, 26, 31, Ovid Technologies (Wolters Kluwer Health), 13 Oct. 2025
Scientific journal, Purpose of review

Modern-type depression (MTD) has emerged as a distinct psychopathological construct in the context of 21st-century societal, technological, and cultural transformations in Japan. First described by Tarumi and then refined by Kato et al. , it has since been recognized internationally. MTD diverges from classical melancholic depression in aetiology, phenomenology, and therapeutic response.

Recent findings

It is especially prevalent among adolescents and young adults exposed to accelerated social rhythms, digital hyperconnectivity, and precarious work and relational structures. Clinically, MTD is characterized by avoidance of social roles, heightened sensitivity to interpersonal conflict, externalized complaints, emotional withdrawal, and tension between authentic and idealized selves. Unlike traditional depression, pharmacological treatments often yield limited benefit or worsen symptoms, underscoring the need for psychosocial and community-based interventions. Promising approaches include interpersonal counselling, psychoeducation, stress management, cognitive-behavioural therapy, physical activity, and neuromodulation techniques such as transcranial direct current stimulation.

Summary

The advent of MTD highlights how socio-cultural acceleration and technological mediation shape mental health, exposing the limitations of conventional diagnostic frameworks. It also provides a valuable opportunity to investigate how social change influences psychopathology and to design culturally sensitive, developmentally informed strategies for prevention and treatment in younger populations.

Improvement of Game Users' Depressive Symptoms via Behavioral Activation in a Massive Multiplayer Online Game: Randomized Controlled Trial.
Kenji Yokotani, Masanori Takano, Nobuhito Abe, Takahiro A Kato
JMIR serious games, 13, e73734, 24 Sep. 2025, [International Magazine]
English, Scientific journal, BACKGROUND: Online games developed to improve mental health symptoms are reportedly effective among game users. However, it has not been verified whether massive multiplayer online games (MMOGs) developed for leisure purposes are effective in improving users' mental health symptoms. OBJECTIVE: Based on 2 theoretical frameworks, this study examined whether MMOGs improve depression and social anxiety. First, behavioral activation theory posits that depressive symptoms improve through the repetition of reward-linked behaviors. Second, inhibitory learning theory suggests that exposure to social stimuli (eg, being the center of attention) previously perceived as threatening reduces fear responses over time. METHODS: Participants were Pigg Party users with at least 3 months of previous experience. Overall, 1105 participants were randomly assigned to either the experimental (n=548) or waitlist groups (n=557). Participants in the experimental group were instructed to ring a friend's room bell (an action that clearly draws attention) on weekdays and to customize their avatars on weekends. Those completing ≥60% of the tasks received additional monthly rewards. The waitlist group received no interventions but was given random additional rewards. Both groups completed questionnaires on depression (Quick Inventory of Depressive Symptomatology) and social anxiety (Brief Liebowitz Social Anxiety Scale) at baseline, and again at 1, 2, and 3 months. RESULTS: The experimental group showed a significantly higher frequency of bell ringing compared to that of the waitlist group (standardized mean difference [SMD]=0.13), whereas no significant difference was observed between the groups in avatar customization frequency. As predicted, the experimental group showed a significantly greater reduction in depressive symptoms, with a small effect size observed (SMD=-0.12). However, no significant difference was determined between groups in social anxiety symptoms. CONCLUSIONS: This study demonstrated that MMOGs, when combined with administrator-led interventions, can reduce users' depressive symptoms, albeit with a small effect size. Further studies are needed to test the intervention effects on social anxiety symptoms in MMOGs, with improved exposure scenarios.

Glutamate in cerebrospinal fluid as a diagnostic marker for acute encephalopathy in childhood.
Kenta Kajiwara, Daiki Setoyama, Kanako Higashi, Tomoko Nomiyama, Yuko Ichimiya, Daichi Kumamoto, Satoshi Akamine, Yuri Sonoda, Pin Fee Chong, Ryuichi Takemoto, Wakato Matsuoka, Soichi Mizuguchi, Noriyuki Kaku, Takahiro A Kato, Tomohiko Akahoshi, Yuya Kunisaki, Yasunari Sakai, Shouichi Ohga
Brain & development, 47, 5, 104448, 104448, 24 Sep. 2025, [International Magazine]
English, Scientific journal, BACKGROUNDS: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is the most frequent form of acute encephalopathy in early childhood in Japan. Magnetic resonance imaging provides useful hallmarks of diagnosing AESD. However, metabolomic profiles for AESD remain elusive. This study investigates whether measurement of amino acids in the cerebrospinal fluid (CSF) is useful for the diagnosis of AESD before onset. METHODS: In the first study, CSF samples were collected from patients (11 AESD and 17 controls) admitted to Kyushu University Hospital during 2011-2016. Amino acids in the CSF were analyzed using mass spectrometry. Cytometric bead arrays were used to measure cytokine and chemokine levels in the CSF. The second study was performed by recruiting patients (8 AESD patients and 10 controls) admitted during 2011-2024. CSF samples were stored at -20 °C for 1 month to 12 years. RESULTS: In the first study, glutamate levels in the CSF from AESD patients were higher than in controls and correlated with methionine, threonine, and tyrosine levels. A correlation map of cytokines and amino acids revealed that glutamate formed a cluster with IL-1β, IL-10, and IL-12 p70. In the second study, no difference in glutamate levels was observed between AESD and control groups. CONCLUSIONS: CSF glutamate potentially serves as a useful marker for diagnosing AESD. The long-term storage of CSF samples was likely to cause a decay of glutamate in the CSF. Prospective studies using fresh CSF samples are necessary to validate the results in this study.

Clozapine-induced slowing in quantitative EEG: Delta-theta amplification and alpha peak shift in TRS patients.
Ryo Sawagashira, Shuhei Ishikawa, Atsuhito Toyomaki, Toru Horinouchi, Naoki Hashimoto, Takahiro A Kato
PCN reports : psychiatry and clinical neurosciences, 4, 3, e70186, Sep. 2025, [International Magazine]
English

A Network Analysis of Psychiatric Symptoms in Patients With Schizophrenia Treated With Antipsychotic Polypharmacy Using Propensity Score Matching: Findings From the Research on Asian Psychotropic Prescription Patterns (REAP) Study.
Wen Li, Qinge Zhang, Gabor S Ungvari, Seon-Cheol Park, Lian-Yu Chen, Kok Yoon Chee, Roy Abraham Kallivayalil, Kang Sim, Yan-Ling He, Norman Sartorius, Naotaka Shinfuku, Shih-Ku Lin, Ajit Avasthi, Sandeep Grover, Takahiro A Kato, Chee H Ng, Yu-Tao Xiang
Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists, 17, 3, e70005, Sep. 2025, [International Magazine]
English, Scientific journal, OBJECTIVES: Antipsychotic polypharmacy (APP) is prevalent among patients with schizophrenia across countries in Asia. This study aimed to explore the relationships between psychiatric symptoms and APP using network analysis. METHODS: Data on nine major psychiatric symptoms and the number of prescribed antipsychotics were extracted from the fourth survey of the Research on Asian Psychotropic Prescription Patterns (REAP-AP). A network model of the nine psychiatric symptoms was constructed for patients treated with APP and antipsychotic monotherapy (APM) respectively. The interconnections between psychiatric symptoms and APP use were further analyzed using network analysis. RESULTS: A total of 1528 patients with schizophrenia treated with APP were matched with 1528 patients treated with APM in Asia. The top three central psychiatric symptoms in the networks of psychiatric symptoms were consistent, but in different orders for APP-treated patients (verbal aggression, hallucinations, and social/occupational dysfunction) and APM-treated patients (social/occupational dysfunction, verbal aggression, and hallucinations). Network analysis of APP and psychiatric symptoms revealed that disorganized/catatonic behavior was strongly linked with APP, followed by delusions, hallucinations, and verbal aggression. CONCLUSION: Psychiatric symptoms closely associated with APP included verbal aggression, grossly disorganized/catatonic behavior, delusions, and hallucinations. For patients with schizophrenia who are primarily exhibiting such symptoms, alternative appropriate treatment strategies should be considered.

Acute and long-term effects of repeated ketamine infusions in treatment-resistant depression and associated metabolite changes.
Hitoshi Sakurai, Daiki Setoyama, Takahiro A Kato, Hisateru Tachimori, Masami Murao, Yasuyuki Matsumoto, Teruo Tada, Yayoi Imamura, Hiroyuki Seki, Takashi Tsuboi, Hiroyuki Uchida, Koichiro Watanabe
Psychiatry and clinical neurosciences, 15 Jul. 2025, [International Magazine]
English, Scientific journal, AIM: This study aims to investigate the acute and sustained antidepressant effects of repeated ketamine infusions in patients with treatment-resistant depression (TRD), and to identify early metabolomic changes predictive of treatment outcomes using metabolome analyses. METHODS: This open-label study investigated the effects of four intravenous ketamine infusions (0.5 mg/kg) administered over 2 weeks in 30 patients with TRD. Clinical outcomes, including the Montgomery-Åsberg Depression Rating Scale (MADRS), were evaluated at baseline, 1-2 h after each infusion, and monthly during a 12-month follow-up. Plasma levels of 11 depression-associated metabolites were measured at baseline and 1.5-2 h after the first infusion. A general linear model was employed to analyze the association between metabolite changes after the first infusion and the MADRS score percent improvements after the fourth infusion and at 12 months. Remission was defined as a MADRS score of ≤10. RESULTS: All participants completed the four infusions. The MADRS score decreased from 30.6 ± 6.1 at baseline to 20.3 ± 11.5 after the fourth infusion, with a remission rate of 26.7%. At 12 months, 13.3% of participants remained in remission. Changes in 3-hydroxybutyrate levels after the first infusion predicted the MADRS score percent improvements after the fourth infusion (β = 1.35, 95% CI: 0.41-2.30, P = 0.005) and at 12 months (β = 1.38, 95% CI: 0.37-2.39, P = 0.007). CONCLUSION: While repeated ketamine infusions demonstrated rapid antidepressant effects, sustained remission was achieved in a minority of patients with TRD. 3-Hydroxybutyrate may serve as a biomarker for predicting treatment response. These findings underscore the potential for individualized strategies using ketamine infusions. CLINICAL TRIAL REGISTRATION: jRCTs031210648 (Japan Registry of Clinical Trials).

Diagnostic distribution of antidepressant users: Findings from the REAP-AD3 study.
Huang-Li Lin, Yueh-Pin Lin, Tian-Mei Si, Roy Abraham Kalliyalil, Andi J Tanra, Amir Hossein Jalali Nadoushan, Toshiya Inada, Seon-Cheol Park, Kok Yoon Chee, Afzal Javed, Kang Sim, Kuan-Lun Huang, Pornjira Pariwatcharakul, Norman Sartorius, Mian-Yoon Chong, Naotaka Shinfuku, Takahiro A Kato, Shih-Ku Lin
Asian journal of psychiatry, 111, 104617, 104617, 06 Jul. 2025, [International Magazine]
English

Sex Differences in the Network Structures of Depressive Symptom Profiles in Asian Patients with Depressive Disorders: Findings From the REAP-AD3.
Han Seul Kim, Seonjae Lee, Jeongha Lee, Tae Young Choi, Sung-Won Jung, Hyung-Jun Yoon, Hyun Soo Kim, Yangsik Kim, Hyun-Ju Yang, Narae Jeong, Eunsoo Moon, Daeho Kim, Tian-Mei Si, Roy Abraham Kallivayalil, Andi J Tanra, Amir Hossein Jalali Nadoushan, Kok Yoon Chee, Afzal Javed, Kang Sim, Pornjira Pariwatcharakul, Mian-Yoon Chong, Toshiya Inada, Shih-Ku Lin, Norman Sartorius, Naotaka Shinfuku, Takahiro A Kato, Jae-Hon Lee, Seon-Cheol Park
Acta neuropsychiatrica, 1, 49, 20 Jun. 2025, [International Magazine]
English, Scientific journal, BACKGROUND: Depression is a complex mental health disorder with highly heterogeneous symptoms that vary significantly across individuals, influenced by various factors, including sex and regional contexts. Network analysis is an analytical method that provides a robust framework for evaluating the heterogeneity of depressive symptoms and identifying their potential clinical implications. OBJECTIVE: To investigate sex-specific differences in the network structures of depressive symptoms in Asian patients diagnosed with depressive disorders, using data from the Research on Asian Psychotropic Prescription Patterns for Antidepressants, Phase 3, which was conducted in 2023. METHODS: A network analysis of 10 depressive symptoms defined according to the National Institute for Health and Care Excellence guidelines was performed. The sex-specific differences in the network structures of the depressive symptoms were examined using the Network Comparison Test. Subgroup analysis of the sex-specific differences in the network structures was performed according to geographical region classifications, including East Asia, Southeast Asia, and South or West Asia. RESULTS: A total of 998 men and 1,915 women with depression were analysed in this study. The analyses showed that all 10 depressive symptoms were grouped into a single cluster. Low self-confidence and loss of interest emerged as the most central nodes for men and women, respectively. In addition, a significant difference in global strength invariance was observed between the networks. In the regional subgroup analysis, only East Asian men showed two distinct clustering patterns. In addition, significant differences in global strength and network structure were observed only between East Asian men and women. CONCLUSION: The study highlights the sex-specific differences in depressive symptom networks across Asian countries. The results revealed that low self-confidence and loss of interest are the main symptoms of depression in Asian men and women, respectively. The network connections were more localised in men, whereas women showed a more diverse network. Among the Asian subgroups analysed, only East Asians exhibited significant differences in network structure. The considerable effects of neurovegetative symptoms in men may indicate potential neurobiological underpinnings of depression in the East Asian population.

Antipsychotic prescription pattern in ASEAN: Comparison of antipsychotic prescription formulation and type from REAP-AP4 consortium study.
Margarita M Maramis, Jakobus Gerick Pantouw, Isa Multazam Noor, Andi J Tanra, Pornjira Pariwatcharakul, Nopporn Tantirangsee, Kok Yoon Chee, Win Aung Myint, Tin Oo, Ee-Heok Kua, Tran Van Cuong, Shih-Ku Lin, Yu-Tao Xiang, Yang Shu-Yu, Lian Yu Chen, Tan Chay Hoon, Naotaka Shinfuku, Norman Sartorius, Takahiro A Kato, Kang Sim
Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists, 10398562251345320, 10398562251345320, 12 Jun. 2025, [International Magazine]
English, Scientific journal, BackgroundTo date, there has not been an evaluation of antipsychotic prescription practices specific to the Association of Southeast Asian Nations (ASEAN) region. This study examined antipsychotic prescription for schizophrenia patients in ASEAN countries based on Research on Asian Psychotropic Prescription (REAP) survey.MethodsThis study used data from the fourth REAP antipsychotic survey (REAP-AP4), conducted between March and May 2016 using standardized procedures. In total, 1817 adult schizophrenia patients from six ASEAN countries were analysed.ResultsPrescription formulation was significantly associated with illness duration (G (24) = 150.595, p < .001) and prescribing country (G (20) = 571.423, p < .001). Oral antipsychotic monotherapy was the most common prescription across all illness durations, with a decreasing trend from 3-6 months to 10-20 years. Oral antipsychotic monotherapy was also the most commonly used prescription in almost all countries. The frequency of long-acting injection (LAI)-oral combination antipsychotic prescription increased with the patient's illness duration and is more commonly prescribed in Malaysia, Singapore, and Thailand.ConclusionLAI-oral combination antipsychotics were prescribed more frequently within patients with longer duration of illness in more developed countries. Antipsychotic monotherapy and oral antipsychotic prescriptions were prevalent across all illness durations and in most ASEAN countries.

Adjunctive Antidepressant Use in Bipolar Disorder and Its Clinical Correlates: An Asian Psychotropic Prescription Patterns Consortium Study.
Yi Hu, Qian Hui Chew, Shih-Ku Lin, Wen-Chen Ouyang, Chih-Ken Chen, Seon-Cheol Park, Ok-Jin Jang, Kok-Yoon Chee, Kwong Sen Ding, Jamaline Chong, Ling Zhang, Keqing Li, Xiaomin Zhu, Chonnakarn Jatchavala, Pornjira Pariwatcharakul, Roy A Kallivayalil, Sandeep Grover, Ajit Avasthi, Moin Ansari, Margarita M Maramis, Phyo Aung Paing, Chay Hoon Tan, Yu-Tao Xiang, Mian-Yoon Chong, Yong Chon Park, Takahiro A Kato, Naotaka Shinfuku, Ross J Baldessarini, Kang Sim
Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists, 17, 2, e70004, Jun. 2025, [International Magazine]
English, Scientific journal, INTRODUCTION: Adjunctive antidepressant (AD) use is prevalent for the treatment of bipolar disorder (BD) in many countries, but there is little information about this practice in Asia. Accordingly, we addressed the prevalence, dosing, and clinical correlates of adjunctive AD use with BD in a large Asian sample. METHODS: Patients with BD were recruited across 13 Asian sites (PR China, Hong Kong, India, Indonesia, Japan, South Korea, Malaysia, Myanmar, Pakistan, Singapore, Sri Lanka, Taiwan, and Thailand) for this cross-sectional study. We examined differences between patients with versus without adjunctive AD treatment. Multivariable logistic regression was used to identify factors associated with the use of adjunctive AD. RESULTS: Among a total of 2114 adult participants (47.7% men; age 42.4 years [CI: 41.8-43.0]; BMI 25.0 kg/m2 [24.8-25.2]), the prevalence of AD use averaged 19.8% [18.1-21.6], at a mean imipramine-equivalent dose of 113 [110-116] mg/day. Adjunctive AD use was associated with factors including older age, outpatient status, more depression, suicidal behavior, rapid cycling, and lower doses of MS and antipsychotics (APs). DISCUSSION: Usage of AD treatment for BD in Asia was less than half that reported in Western samples. Such use of AD treatment appeared to be well tolerated but underscores the need for close clinical follow-up to avoid risks of excessive elevation of mood or behavior.

Global psychiatrists' opinions about hikikomori from biopsychosocial perspectives: International case vignette survey.
Marcus P J Tan, Kohei Hayakawa, Yukako Nakagami, Victor Pereira-Sanchez, Seon Cheol Park, Yong Chon Park, Seok Woo Moon, Tae Young Choi, Yu-Tao Xiang, Kang Sim, Toru Horinouchi, Ajit Avasthi, Sandeep Grover, Roy Abraham Kallivayalil, Yugesh Rai, Mohammadreza Shalbafan, Pavita Chongsuksiri, Pichet Udomratn, Samudra T Kathriarachchi, Afzal Javed, Mian-Yoon Chong, Tan Chay-Hoon, Toshiya Inada, Toshiya Murai, Tomohiro Nakao, Shigenobu Kanba, Shih-Ku Lin, Norman Sartorius, Naotaka Shinfuku, Takahiro A Kato
PCN reports : psychiatry and clinical neurosciences, 4, 2, e70120, Jun. 2025, [International Magazine]
English, Scientific journal, AIM: The aim of this study was to investigate whether psychiatrists around the world believe they might encounter cases of hikikomori (prolonged social isolation), and how they formulate and treat such cases. METHODS: A hikikomori case vignette was sent to psychiatrists of 34 countries around the world. Participants rated for the vignette: frequency of similar cases in one's practicing country; and aspects of formulation, diagnosis, suicide risk, and treatment plan. RESULTS: In total, 344 complete responses from 34 countries were returned. Eight countries/areas had 10 or more respondents: Japan (61), South Korea (54), Nepal (48), Iran (40), Thailand (32), India (23), Hong Kong (12), and UK (10); the remainder were placed in the "others" group (64). Respondents from all countries except Thailand felt that similar cases were seen. Diverse patterns of response were obtained regarding formulation and treatment. Japan, South Korea, and "others" favored psychosocial aspects in the formulation, while Iran, Nepal, and India favored biological factors. Most respondents felt the case could be treated by an outpatient visit, while others preferred hospitalization. Psychotherapy was rated highly as an intervention; Iran, South Korea, and "others" also rated pharmacotherapy highly. CONCLUSION: Despite its limitations as an exploratory study, we found evidence that hikikomori-like cases might exist around the world. However, opinions on how such cases should be formulated and treated vary significantly among countries. We believe this reflects how the experience of hikikomori is dependent on the related sociocultural context. Further comparative work, preferably with standardized assessment tools, will help to clarify how society might influence the individual experiences of practitioner and hikikomori patients.

Network structure of social withdrawal symptoms in Asian psychiatric patients at high risk of hikikomori: Findings from the REAP-AD3.
Seonjae Lee, Han Seul Kim, Jiyoung Hong, Eunjae Lee, Eunkyung Kim, Tae Young Choi, Seok Woo Moon, Sung-Won Jung, Hyung-Jun Yoon, Hyun Soo Kim, Ji Hyun Baek, Tian-Mei Si, Roy Abraham Kallivayalil, Andi J Tanra, Amir Hossein Jalali Nadoushan, Kok Yoon Chee, Afzal Javed, Kang Sim, Pornjira Pariwatcharakul, Mian-Yoon Chong, Yukako Nakagami, Toshiya Inada, Eunsoo Moon, Shih-Ku Lin, Norman Sartorius, Naotaka Shinfuku, Takahiro A Kato, Seon-Cheol Park
Asian journal of psychiatry, 108, 104489, 104489, Jun. 2025, [International Magazine]
English, Scientific journal, BACKGROUND: Hikikomori is a severe pathological form of social withdrawal that first emerged in Japan in the late 20th century and has since become a global phenomenon. This was recently added to the cultural concept of distress in the DSM-5-TR. OBJECTIVE: This study aimed to examine the precise network structure of social withdrawal symptoms in Asian psychiatric patients at high risk of hikikomori using data from Phase 3 of the Research on Asian Psychotropic Prescription Patterns for Antidepressants. METHODS: High risk of hikikomori was defined as a score ≥ 42 on the 1-month version of the 25-item Hikikomori Questionnaire (HQ-25M), a scale that measures social withdrawal symptoms. The HQ-25M network structures were estimated separately for patients at high and low risks of hikikomori. The differences in network structure invariance and global strength invariance between the two networks were evaluated. Data from 2993 participants were assessed, including 1939 and 1054 patients at high and low risk of hikikomori, respectively. RESULTS: Network analysis revealed that enjoyment of social activities was the most central symptom among patients at high risk of hikikomori, whereas trust issues were the most central among those at low risk of hikikomori. In addition, although no significant differences were identified in the overall network structures, the global strength invariance differed significantly between networks. CONCLUSION: While the study has several limitations, the findings may point to potential differences in how social withdrawal symptoms are structured between individuals with high versus low risk of hikikomori, particularly with regard to the overall connectivity among symptoms. A notable finding is that low enjoyment of social interactions may be a main area for early intervention. However, given that the participants were all psychiatric patients receiving antidepressant medication and able to attend in-person evaluations, the applicability of these results to non-clinical groups or individuals with more severe social withdrawal may be restricted.

Urbanization and emerging mental health problems: the role of the WPA Section on Urban Mental Health.
Takahiro A Kato, Norman Sartorius, Umberto Volpe, Naotaka Shinfuku, Jair de Jesus Mari
World psychiatry : official journal of the World Psychiatric Association (WPA), 24, 2, 290, 291, Jun. 2025, [International Magazine]
English

C5a in the peripheral plasma of female fibromyalgia patients is elevated but not related to pain sensitivity as in healthy controls.
Koji Fujimoto, Kozo Anno, Yu Tanaka, Masafumi Murakami, Shogo Inamine, Takahiro A Kato, Nobuyuki Sudo, Masako Hosoi
Scientific reports, 15, 1, 17387, 17387, 19 May 2025, [International Magazine]
English, Scientific journal, Although evidence from basic studies indicates that C5a induces hyperalgesia, knowledge from studies of humans is limited. This comparative analysis of the peripheral blood C5a concentration of women diagnosed with fibromyalgia (FM) who exhibited widespread pain and that of female healthy controls (HCs) was done to assess possible correlations of C5a concentration with pain threshold. The data of 30 patients with FM and 29 HCs were included in the analysis. C5a concentration in the peripheral blood was quantified by ELISA, and the cold pain threshold (CPT) was assessed. The correlation between C5a concentration and CPT was analyzed using the Spearman correlation coefficient, and the peripheral blood C5a concentrations of FM and HC were compared by t-test. The mean (standard deviation) peripheral blood C5a concentrations of FM and HC were 12.7 (6.48) ng/ml and 8.82 (4.79) ng/ml, respectively (p = 0.0114). Although no significant relation was observed between CPT and C5a concentration in FM (R = - 0.12, p = 0.52), a significant correlation was found for HC (R = 0.41, p = 0.03). The results suggest that C5a would be a potential biomarker for the pain sensitivity of women and give new insights into the pathophysiology of FM.

Hikikomori Diagnostic Evaluation-Screening Form (HiDE-S): A validation study.
Salvatore Reina, Taisei Kubo, Laura Orsolini, Toshio Matsushima, Sota Kyuragi, Keitaro Matsuo, Tomohiro Nakao, Umberto Volpe, Takahiro A Kato
Psychiatry and clinical neurosciences, 13 May 2025, [International Magazine]
English

Network Structure of Depression and Anxiety Symptoms in Older Asian Patients With Depressive Disorders: Findings From REAP-AD3.
Seon-Cheol Park, Kiwon Kim, Jeongsoo Park, Sun Choi, Seonhwa Lee, Seungwon Cho, Eunkyung Kim, Tian-Mei Si, Roy Abraham Kallivayalil, Andi J Tanra, Amir Hossein Jalali Nadoushan, Kok Yoon Chee, Afzal Javed, Kang Sim, Pornjira Pariwatcharakul, Takahiro A Kato, Shih-Ku Lin, Naotaka Shinfuku, Norman Sartorius
Psychiatry investigation, 22, 5, 552, 563, May 2025, [International Magazine]
English, Scientific journal, OBJECTIVE: The clinical presentation of depressive disorders might be influenced by age, and its diagnosis and treatment can be affected by ageism-related bias. A network analysis can reveal symptom patterns unrecognized by the reductionistic approach. Therefore, this study explores the network structure of depression and anxiety symptoms in older Asian patients with depressive disorders and examines age-related differences in the context of ageism. METHODS: We used data from the Research on Asian Psychotropic Prescription Patterns for Antidepressants, Phase 3 study and included 2,785 psychiatric patients from 11 Asian countries. Depression and anxiety symptoms were assessed using the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7. Network analyses were conducted to identify symptom interconnections and centrality among older (>65 years), middle-aged (35-64 years), and young (18-34 years) adult groups. The network structures were also compared using a network comparison test. RESULTS: Depressed mood was the most central symptom across all age groups. Network comparisons revealed no significant structural differences among the three age groups, despite several variations in terms of global strength. The network structure of the older group was characterized by strong interconnections between somatic symptoms (insomnia-energy) and core depressive symptoms (little interest or pleasure-feelings of hopelessness). CONCLUSION: This study reveals that the network structures of depression and anxiety symptoms have relatively consistent interconnections across age groups, despite subtle age-based differences. Specifically, older adults tend to present anxiety and depression symptoms as physical complaints. These findings challenge ageist stereotypes and advocate for inclusive, age-neutral approaches to treatment.

Virtual reality as a novel therapeutic tool in psychiatry: will virtual reality intervention for families rescue hikikomori?
Taisei Kubo, Takahiro A Kato
Current opinion in psychiatry, 38, 3, 227, 234, 01 May 2025, [International Magazine]
English, Scientific journal, PURPOSE OF REVIEW: Digital technology is beginning to revolutionize psychiatry. Virtual reality (VR) allows users to experience a virtual space through their three primary senses. In psychiatry, social skills training (SST), including role-play, has been introduced in occupational therapy to improve patients' social abilities. In face-to-face SST, the therapist's leadership skills and the patient's ability to deal with situations are necessary. VR could resolve such limitations. Herein, we introduce recent advances in VR for psychiatry. RECENT FINDINGS: The introduction of VR has improved the social skills of patients with schizophrenia, social anxiety, and autism spectrum disorder. We have introduced VR not only for psychiatric patients themselves but also for their family members to improve their skills in intervening with the patients, especially hard-to-reach patients such as hikikomori (social withdrawal). A pilot trial was conducted involving several family cases living with people with hikikomori, and this approach showed promising effectiveness. SUMMARY: VR has the potential to overcome the problems of conventional treatments by enabling experiential learning. In the future, VR is expected to support not only patients with mental disorders but also to improve the skills of therapists and caregivers, including family members. Empirical research through industry-academia collaboration is desirable for spreading VR-based interventions in psychiatry.

Depression, Gaming Disorder, and Internet Addiction in Adolescents with Autism Spectrum Disorder.
Masaru Tateno, Yukie Tateno, Tomohiro Shirasaka, Kotaro Nanba, Eri Shiraishi, Ryotaro Shimomura, Takahiro A Kato
Behavioral sciences (Basel, Switzerland), 15, 4, 26 Mar. 2025, [International Magazine]
English, Scientific journal, Adolescents with autism spectrum disorder (ASD) often have various psychiatric comorbidities, particularly depression. In recent years, gaming disorder (GD) and Internet addiction (IA) have been identified as common comorbidities of ASD. We administered three self-administered screening instruments to adolescents with ASD to assess the severity of depression, GD, and IA. The participants were 10-18-year-olds with ASD. They were asked to complete three questionnaires to assess depressive symptoms, GD, and IA: the Patient Health Questionnaire for Adolescents (PHQ-A), Ten-Item Internet Gaming Disorder Test (IGDT-10), and Internet Addiction Test (IAT). The total IGDT-10 score was calculated in two different ways: the original scoring version (IGDT-10-OV) and the modified version (IGDT-10-MV). Of the 74 respondents, 24.3% had moderate or severe depressive symptoms, 8.1% were identified as having possible GD according to the IGDT-10-OV, 39.2% were identified as having possible GD according to the IGDT-10-MV, and 27.0% were positive for IA according to the IAT. Two-group comparisons revealed that depressive symptoms were more strongly associated with IA than with GD. IA was associated with more depressive symptoms than GD. Since adolescents with ASD have difficulties with social communication, they are prone to isolation and feelings of loneliness. Longer screen times due to social isolation may be a risk factor for the development of GD/IA. Adolescents with ASD often exhibit a preference for visual processing but may struggle with verbal communication. Thus, they may find online spaces more comfortable for them to alleviate their feelings of loneliness.

The rate of patients screened positive for gaming disorder/Internet gaming disorder among adolescents with mental health issues assessed by two screening tests: A nine-item screening test for GD (GAMES Test) and the Ten-Item Internet Gaming Disorder Test (IGDT-10).
Masaru Tateno, Takanobu Matsuzaki, Ayumi Takano, Yukie Tateno, Takahiro A Kato, Susumu Higuchi
PCN reports : psychiatry and clinical neurosciences, 4, 1, e70080, Mar. 2025, [International Magazine]
English, Scientific journal, AIM: The aim of this study is to estimate the rate of patients who screened positive for gaming disorder (GD) in ICD-11 among adolescents with psychiatric and/or developmental disorders by using two screening tests: a nine-item screening test for GD, GAMing Engagement Screening test (GAMES Test), and the Ten-Item Internet Gaming Disorder Test (IGDT-10). METHODS: Subjects were 257 adolescent patients attending a psychiatric clinic in Sapporo, Japan. They were asked to complete two questionnaires. The total score on the IGDT-10 was calculated by two different scoring methods, original version (OV) and modified version (MV). The three groups were also compared on the basis of their clinical diagnoses. RESULTS: Of the 203 respondents, 42 (20.7%) screened positive using the GAMES Test. With respect to the IGDT-10, only eight (3.9%) screened positive using the IGDT-10 OV scoring, while 55 (27.1%) screened positive using the IGDT-10 MV. The most notable finding was that the mean total scores on the GAMES Test and the IGDT-10 MV were significantly higher in the attention deficit hyperactivity disorder group than in the other two groups (depression and autism spectrum disorder). CONCLUSION: The results of this study showed that adolescents with mental health problems had a higher rate of screening positivity on self-rated screening tools for GD than the general population. Because excessive gaming has a wide range of adverse effects on adolescents' mental health, early detection of probable GD is crucial. Screening for GD should be part of routine clinical practice.

Exploring the Bidirectional Relationship Between Depression and Obesity.
Seon-Cheol Park, Takahiro A Kato, Jae-Hon Lee, Sung Hoon Yu
Endocrinology and metabolism clinics of North America, 54, 1, 193, 206, Mar. 2025, [International Magazine]
English, Scientific journal, The paper explores the intricate bidirectional relationship between depression and obesity, emphasizing that each condition increases the risk of the other. Shared biologic mechanisms, such as neuroinflammation, dysregulation of the hypothalamic-pituitary-adrenal axis, and dysfunction of the gut-brain axis, contribute to the co-occurrence of these conditions. In addition, the emerging social withdrawal syndrome, hikikomori, is suggested as an associated socio-behavioral factor with the comorbidity of depression and obesity. Among antidepressants, selective serotonin reuptake inhibitors and bupropion (a norepinephrine/dopamine reuptake inhibitor), but not tricyclic antidepressants, are considered pharmacotherapeutic options for the co-occurrence of depression and obesity.

Predicting social anxiety disorder based on communication logs and social network data from a massively multiplayer online game: Using a graph neural network.
Kenji Yokotani, Masanori Takano, Nobuhito Abe, Takahiro A Kato
Psychiatry and clinical neurosciences, 25 Feb. 2025, [International Magazine]
English, Scientific journal, AIM: Social anxiety disorder (SAD) is a mental disorder that requires early detection and treatment. However, some individuals with SAD avoid face-to-face evaluations, which leads to delayed detection. We aim to predict individuals with SAD based on their communication logs and social network data from a massively multiplayer online game (MMOG). METHOD: The study included 819 users of Pigg Party, a popular MMOG in Japan. Participants completed the Japanese version of the Liebowitz Social Anxiety Scale (LSAS-J) and a social withdrawal scale (hikikomori) questionnaire. Participants scoring ≥60 on the LSAS-J were classified as having SAD, while those scoring <60 were classified as not having SAD (non-SAD). A total of 142,147 users' communication logs and 613,618 social edges from Pigg Party were used as input to predict whether participants had SAD or non-SAD. Graph sample and aggregated embeddings (Graph SAGE) was utilized as a graph neural network model. RESULTS: Individuals with SAD were more likely to be socially withdrawn in the physical community (hikikomori), had fewer friends, spent less time in other users' virtual houses, and showed lower entropy in their visitation times in MMOG. Based on their social network data, the Graph SAGE model predicted SAD, with an F1 score of 0.717. CONCLUSION: The communication logs and social network data in an MMOG include indicators of interpersonal avoidance behaviors, which is typical of individuals with SAD; this suggests their potential use as digital biomarkers for the early detection of SAD.

Association of high complement and low immunoglobulins with the clinical symptoms of patients with fibromyalgia.
Satoshi Izuno, Masako Hosoi, Kozo Anno, Takahiro A Kato, Nobuyuki Sudo, Kazufumi Yoshihara
BioPsychoSocial medicine, 19, 1, 1, 1, 21 Jan. 2025, [International Magazine]
English, Scientific journal, BACKGROUND: Fibromyalgia (FM) is a disease characterized by chronic widespread pain concomitant with various symptoms such as fatigue and anxiety. Although chronic inflammation has been implicated in the immunological abnormalities of FM, there are few human studies on complement and immunoglobulins. In this study, we investigated the immunological characteristics of FM patients and the association between their clinical symptoms and immunological indices, including complement and immunoglobulins. METHODS: 1) The serum 50% hemolytic complement activity (CH50), C3, C4, IgG, IgM, and hsCRP of 36 FM patients and 30 healthy sex- and age-matched controls (HC) were measured and compared. 2) Data from the Brief Pain Inventory (pain intention and pain interference subscales), the visual analog scale (VAS) (low back pain, knee pain, and fatigue), the State-Trait Anxiety Inventory and the Center for Epidemiologic Studies Depression Scale (anxiety and depression), and CH50, IgG, and hsCRP as immunological indices were acquired for 41 FM patients. Correlation analysis was done of the clinical symptom and immunological indices. RESULTS: 1) The FM group had significantly higher CH50 and lower IgG and IgM than the HC group after adjusting for body mass index (BMI). 2) Correlation analysis of immunological indices and clinical symptoms showed a positive, partial correlation between CH50 and fatigue and trait anxiety after adjusting for sex, age, and BMI. CONCLUSIONS: FM patients had higher CH50 and lower immunoglobulin levels than HCs. CH50 was also associated with the fatigue and trait anxiety of FM patients. Further studies are needed to determine whether changes in these immunological indices can be used as biomarkers and/or therapeutic targets for FM.

Long-acting injectable antipsychotic use in patients with bipolar disorder: Findings from the REAP-BD study.
Chun Lin, Yueh-Pin Lin, Seon-Cheol Park, Ok-Jin Jang, Tian-Mei Si, Yu-Tao Xiang, Huang-Li Lin, Afzal Javed, M Nasar Sayeed Khan, Sandeep Grover, Roy Abraham Kallivayali, Kok Yoon Chee, Takahiro A Kato, Pornjira Pariwatcharakul, Margarita Maramis, Lakmi Seneviratne, Kang Sim, Wai Kwong Tang, Tin Oo, Norman Sartorius, Chay-Hoon Tan, Mian-Yoon, Naotaka Shinfuku, Shih-Ku Lin
Asian journal of psychiatry, 103, 104338, 104338, Jan. 2025, [International Magazine]
English, Scientific journal, AIMS: This study aimed to assess treatment patterns and the effectiveness of long-acting injectable antipsychotics (LAIs) in patients with bipolar disorder (BD) across various Asian countries. The study focused on comparing the choices of LAIs, other psychotropic medications, and their psychotropic drug load to explore real-world usage and evaluate the potential benefits of LAIs in BD treatment across different countries. METHODS: A retrospective cohort study was conducted with BD patients diagnosed according to ICD-10-CM codes F31.0 to F31.9 across 13 Asian countries or regions. Data were collected through an online system covering prescriptions for all psychotropic medications including LAIs. The Anatomical Therapeutic Chemical (ATC) Classification System was used to compare medication dosage patterns. RESULTS: The study analyzed 2029 prescription records for BD, including 103 cases involving LAIs. The highest LAI prescription rates were found in Sri Lanka and Malaysia, with no reported use in Myanmar, India, and Japan. Patients receiving LAIs were younger, more often male, and had higher BMI and drug loads compared to those on oral medications. South Korea and Indonesia showed the highest LAIs drug load. South Korea, Pakistan, and China exhibited the highest total psychotropic drug loads, while Malaysia had the lowest. CONCLUSIONS: This study is the first to examine LAIs use for BD across Asia. Cross-national differences in LAIs prescriptions and psychotropic drug load highlight variations in treatment practices and healthcare systems. These findings underscore the need for further research and the development of region-specific guidelines to improve BD treatment outcomes.

The flow cytometric analysis of depression focusing on modern-type depression and hikikomori: Exploring the link between subtypes of depression and immunological imbalances.
Keitaro Matsuo, Mitsuru Watanabe, Shogo Inamine, Toshio Matsushima, Sota Kyuragi, Yasuhiro Maeda, Ryoko Katsuki, Masahiro Ohgidani, Ryo Yamasaki, Noriko Isobe, Tomohiro Nakao, Takahiro A Kato
Dialogues in clinical neuroscience, 27, 1, 13, 25, Jan. 2025, [International Magazine]
English, Scientific journal, INTRODUCTION: Depression includes different phenotypes. Modern-type depression (MTD) is a gateway disorder to pathological social withdrawal, known as hikikomori. Adverse childhood experiences (ACEs) are also important aetiologies of depression. Recently, immune imbalance has been proposed as a biological basis of depression. We hypothesised that peripheral immunological characteristics may be involved in subtyping of depression. METHODS: 21 patients with major depressive disorder (MDD) and 24 healthy controls (HC) were recruited. Peripheral blood mononuclear cells (PBMCs) were examined for surface antigens by flow cytometry. Participants were administered psychological scales such as Patient Health Questionnaire (PHQ)-9, Modern-Type Depression Trait Scale (TACS-22), Hikikomori Questionnaire (HQ-25), Child Abuse and Trauma Scale (CATS). RESULTS: MDD group showed significantly higher percentage of B cells than HC group (p = 0.032). MDD group presented a negative correlation between: PHQ-9 and CD8 T effector memory cells (r= -0.639, p = 0.002), TACS-22 and monocytes (r= -0.459, p = 0.036), HQ-25 and NK T cells (r= -0.638, p = 0.004), CATS and Intermediate monocytes (r= -0.594, p = 0.009). CONCLUSIONS: MTD traits, hikikomori tendencies, and ACEs were correlated with specific characteristics of peripheral immune cells. Our results suggest that immune imbalance influences the diverse presentations of depression. Further validation is warranted by large-scale prospective studies.

Improving social anxiety in lesbian, gay, bisexual, transgender, questioning, intersex and asexual individuals through avatar customization and communication
Kenji Yokotani, Masanori Takano, Nobuhito Abe, Takahiro A. Kato
Asian Journal of Social Psychology, 28, 1, Wiley, 17 Dec. 2024
Scientific journal, Abstract

Discrimination and prejudice against lesbian, gay, bisexual, transgender, questioning, intersex and asexual+ (LGBTQIA+) individuals exacerbate social anxiety. Communication via avatars in virtual communities may be an effective strategy to reduce related symptoms. This study measured social anxiety in LGBTQIA+ and non‐LGBTQIA+ individuals among Japanese users of Pigg Party, a massively multiplayer online game, in physical and virtual communities that use avatars for communication. They answered questions on social anxiety in physical and virtual communities and avatar identification (i.e., the degree of identification of the avatar with the self). The number of avatar customizations and amount of communication via avatars (indexed by the number of virtual peers) were collected based on game logs. The results revealed that the LGBTQIA+ group exhibited significantly higher rates of social anxiety in physical but not virtual communities than the non‐LGBTQIA+ group. Moreover, the LGBTQIA+ group displayed higher levels of identification with avatars than the non‐LGBTQIA+ group. Increased identification with avatars and avatar customization correlated with an increased number of communications via avatars, which was consequently linked to reduced social anxiety in physical and virtual communities. These findings suggest that communication using avatars can reduce social anxiety among LGBTQIA+ individuals.

Suicidality is most centrally situated within network of depression symptom criteria in unipolar depression patients with mood stabilizer in Asia.
Jin Woong Yoon, Eunkyung Kim, Narae Jeong, Minseok Kang, Han Seul Kim, Seonjae Lee, Hyung-Jun Yoon, Seung-Gon Kim, Euihyeon Na, Hyunju Yang, Joon Hyuk Park, Shu-Yu Yang, Shih-Ku Lin, Xiaomin Zhu, Yu-Tao Xiang, Kang Sim, Chay Hoon Tan, Sandeep Grover, Ajit Avasthi, Roy Abraham Kallivayalil, Margarita M Maramis, Kok Yoon Chee, Pornjira Pariwatcharakul, Tin Oo, Takahiro A Kato, Afzal Javed, Mian-Yoon Chong, Norman Sartorius, Naotaka Shinfuku, Jeongsoo Park, Seon-Cheol Park
Asian journal of psychiatry, 101, 104197, 104197, Nov. 2024, [International Magazine]
English, Scientific journal, Lithium and mood stabilizers are considered effective augmentation agents of antidepressants for treatment-resistant depression. Thus, this study aimed to estimate the network structure of depression symptom criteria among unipolar depression patients with mood stabilizers, using data from the Research on Asian Psychotropic Prescription Patterns for mood stabilizers (REAP-MS). We estimated a network of the 9 depression symptom criteria among 411 unipolar depression patients in Asia. Each of the depression symptom criteria was considered to be a dichotomous categorical variable. Suicidality (suicidal ideation or attempt) was the most centrally situated within the network of depression symptoms, followed by depressed mood, loss of energy, anhedonia and weight loss or gain. Contrastingly, concentration problem was the least interconnected. The depression symptom criteria were organized into 4 clusters by the community detection method. The findings suggest that suicidality may be one of the significant therapeutic target symptoms in unipolar depression patients with mood stabilizers.

Copy number variations in RNF216 and postsynaptic membrane–associated genes are associated with bipolar disorder: a case‐control study in the Japanese population
Masahiro Nakatochi, Itaru Kushima, Branko Aleksic, Hiroki Kimura, Hidekazu Kato, Toshiya Inada, Youta Torii, Nagahide Takahashi, Maeri Yamamoto, Kunihiro Iwamoto, Yoshihiro Nawa, Shuji Iritani, Nakao Iwata, Takeo Saito, Kohei Ninomiya, Tomo Okochi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kenichiro Miura, Kazutaka Ohi, Toshiki Shioiri, Kiyoyuki Kitaichi, Masanari Itokawa, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Tsutomu Takahashi, Michio Suzuki, Takahiro A. Kato, Shigenobu Kanba, Hideki Horikawa, Kiyoto Kasai, Tempei Ikegame, Seiichiro Jinde, Tadafumi Kato, Chihiro Kakiuchi, Bun Yamagata, Shintaro Nio, Yasuto Kunii, Hirooki Yabe, Yasunobu Okamura, Shu Tadaka, Ueno Fumihiko, Taku Obara, Yasuyuki Yamamoto, Yuko Arioka, Daisuke Mori, Masashi Ikeda, Norio Ozaki
Psychiatry and Clinical Neurosciences, Wiley, 15 Oct. 2024
Scientific journal, Aim

Bipolar disorder (BD) is a common psychiatric disorder characterized by alterations between manic/hypomanic and depressive states. Rare pathogenic copy number variations (CNVs) that overlap with exons of synaptic genes have been associated with BD. However, no study has comprehensively explored CNVs in synaptic genes associated with BD. Here, we evaluated the relationship between BD and rare CNVs that overlap with synaptic genes, not limited to exons, in the Japanese population.

Methods

Using array comparative genome hybridization, we detected CNVs in 1839 patients with BD and 2760 controls. We used the Synaptic Gene Ontology database to identify rare CNVs that overlap with synaptic genes. Using gene‐based analysis, we compared their frequencies between the BD and control groups. We also searched for synaptic gene sets related to BD. The significance level was set to a false discovery rate of 10%.

Results

The RNF216 gene was significantly associated with BD (odds ratio, 4.51 [95% confidence interval, 1.66–14.89], false discovery rate < 10%). The BD‐associated CNV that corresponded with RNF216 also partially overlapped with the minimal critical region of the 7p22.1 microduplication syndrome. The integral component of the postsynaptic membrane (Gene Ontology:0099055) was significantly associated with BD. The CNV overlapping with the intron region of GRM5 in this gene set showed a nominal significant association between cases and controls (P < 0.05).

Conclusion

We provide evidence that CNVs in RNF216 and postsynaptic membrane–related genes confer a risk of BD, contributing to a better understanding of the pathogenesis of BD.

Does childhood maltreatment affect hikikomori via traits of modern-type depression?
Ryota Masuda, Ryoko Katsuki, Toshio Matsushima, Sota Kyuragi, Tomohiro Nakao, Takahiro A. Kato
Journal of Affective Disorders, 360, 50, 54, Elsevier BV, Sep. 2024
Scientific journal

Gnao1 is a molecular switch that regulates the Rho signaling pathway in differentiating neurons.
Ryoji Taira, Satoshi Akamine, Sayaka Okuzono, Fumihiko Fujii, Eriko Hatai, Kousuke Yonemoto, Ryuichi Takemoto, Hiroki Kato, Keiji Masuda, Takahiro A Kato, Ryutaro Kira, Keita Tsujimura, Kenichiro Yamamura, Norio Ozaki, Shouichi Ohga, Yasunari Sakai
Scientific reports, 14, 1, 17097, 17097, 24 Jul. 2024, [International Magazine]
English, Scientific journal, GNAO1 encodes G protein subunit alpha O1 (Gαo). Pathogenic variations in GNAO1 cause developmental delay, intractable seizures, and progressive involuntary movements from early infancy. Because the functional role of GNAO1 in the developing brain remains unclear, therapeutic strategies are still unestablished for patients presenting with GNAO1-associated encephalopathy. We herein report that siRNA-mediated depletion of Gnao1 perturbs the expression of transcripts associated with Rho GTPase signaling in Neuro2a cells. Consistently, siRNA treatment hampered neurite outgrowth and extension. Growth cone formation was markedly disrupted in monolayer neurons differentiated from iPSCs from a patient with a pathogenic variant of Gαo (p.G203R). This variant disabled neuro-spherical assembly, acquisition of the organized structure, and polarized signals of phospho-MLC2 in cortical organoids from the patient's iPSCs. We confirmed that the Rho kinase inhibitor Y27632 restored these morphological phenotypes. Thus, Gαo determines the self-organizing process of the developing brain by regulating the Rho-associated pathway. These data suggest that Rho GTPase pathway might be an alternative target of therapy for patients with GNAO1-associated encephalopathy.

An N-terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice.
Sayaka Okuzono, Fumihiko Fujii, Daiki Setoyama, Ryoji Taira, Yohei Shinmyo, Hiroki Kato, Keiji Masuda, Kousuke Yonemoto, Satoshi Akamine, Yuki Matsushita, Yoshitomo Motomura, Takeshi Sakurai, Hiroshi Kawasaki, Kihoon Han, Takahiro A Kato, Hiroyuki Torisu, Dongchon Kang, Yusaku Nakabeppu, Shouichi Ohga, Yasunari Sakai
Genes to cells : devoted to molecular & cellular mechanisms, 04 Jul. 2024, [International Magazine]
English, Scientific journal, An autism-associated gene Shank3 encodes multiple splicing isoforms, Shank3a-f. We have recently reported that Shank3a/b-knockout mice were more susceptible to kainic acid-induced seizures than wild-type mice at 4 weeks of age. Little is known, however, about how the N-terminal and ankyrin repeat domains (NT-Ank) of Shank3a/b regulate multiple molecular signals in the developing brain. To explore the functional roles of Shank3a/b, we performed a mass spectrometry-based proteomic search for proteins interacting with GFP-tagged NT-Ank. In this study, NT-Ank was predicted to form a variety of complexes with a total of 348 proteins, in which RNA-binding (n = 102), spliceosome (n = 22), and ribosome-associated molecules (n = 9) were significantly enriched. Among them, an X-linked intellectual disability-associated protein, Nono, was identified as a NT-Ank-binding protein. Coimmunoprecipitation assays validated the interaction of Shank3 with Nono in the mouse brain. In agreement with these data, the thalamus of Shank3a/b-knockout mice aberrantly expressed splicing isoforms of autism-associated genes, Nrxn1 and Eif4G1, before and after seizures with kainic acid treatment. These data indicate that Shank3 interacts with multiple RNA-binding proteins in the postnatal brain, thereby regulating the homeostatic expression of splicing isoforms for autism-associated genes after birth.

Analysis of Antipsychotic Dosage in Patients With Tardive Dyskinesia: A Case-Control Study Using the Claims Database of the Corporate Health Insurance Association
Maki Gouda, Michikazu Abe, Yumi Watanabe, Takahiro A. Kato
Journal of Clinical Psychopharmacology, 44, 4, 378, 385, Ovid Technologies (Wolters Kluwer Health), 04 Jun. 2024
Scientific journal, Abstract

Purpose

This study aimed to assess the association between antipsychotic doses and the risk of tardive dyskinesia (TD) in clinical practice using a Japanese claims database from 2010 to 2020.

Methods

The study population included patients 15 years or older with a diagnosis record of schizophrenia, depression, or bipolar disorder who were prescribed antipsychotics. Using a case-control design, we categorized patients newly diagnosed with TD as cases, with corresponding 1:10 matching in the control group. The primary endpoint was the relative risk of TD in the >median dose and ≤median dose groups, as determined using conditional logistic regression analysis adjusted for age.

Results

The analysis population included 58,452 patients, and the median daily antipsychotic dose was 75 mg/d of chlorpromazine equivalent (CPZE). Of these, 80 were identified as TD cases, and doses >75 mg/d were associated with a significantly increased risk of TD at the last prescription and the maximum dose, respectively, before the date of the first diagnosis of TD. Post-hoc analysis further showed a significant association between doses ≥300 mg/d and the risk of TD compared to doses ≤75 mg/d and doses >75 to <300 mg/d. Comparing ≥300 mg/d versus >75 to <300 mg/d, the odd ratios at the last prescription and maximum dose before the first diagnosis of TD were 3.40 and 3.50, respectively.

Conclusions

In the Japanese medical claims database of patients receiving relatively low doses of antipsychotics, doses >75 mg/d were associated with an increased risk of TD in a dose-dependent manner.

SENSEI Transference: Teacher (SENSEI) both as an oedipal symbol and hidden AMAE-like attachment symbol in Japan　　　　　　　　　　　　　　　
Kato TA
The Journal of The Japan Psychoanalytic Society, 6, 57, 70, Jun. 2024

ATP1A3 regulates protein synthesis for mitochondrial stability under heat stress.
Fumihiko Fujii, Hikaru Kanemasa, Sayaka Okuzono, Daiki Setoyama, Ryoji Taira, Kousuke Yonemoto, Yoshitomo Motomura, Hiroki Kato, Keiji Masuda, Takahiro A Kato, Shouichi Ohga, Yasunari Sakai
Disease models & mechanisms, 17, 6, 01 Jun. 2024, [International Magazine]
English, Scientific journal, Pathogenic variants in ATP1A3, the gene encoding the α3 subunit of the Na+/K+-ATPase, cause alternating hemiplegia of childhood (AHC) and related disorders. Impairments in Na+/K+-ATPase activity are associated with the clinical phenotype. However, it remains unclear whether additional mechanisms are involved in the exaggerated symptoms under stressed conditions in patients with AHC. We herein report that the intracellular loop (ICL) of ATP1A3 interacted with RNA-binding proteins, such as Eif4g (encoded by Eif4g1), Pabpc1 and Fmrp (encoded by Fmr1), in mouse Neuro2a cells. Both the siRNA-mediated depletion of Atp1a3 and ectopic expression of the p.R756C variant of human ATP1A3-ICL in Neuro2a cells resulted in excessive phosphorylation of ribosomal protein S6 (encoded by Rps6) and increased susceptibility to heat stress. In agreement with these findings, induced pluripotent stem cells (iPSCs) from a patient with the p.R756C variant were more vulnerable to heat stress than control iPSCs. Neurons established from the patient-derived iPSCs showed lower calcium influxes in responses to stimulation with ATP than those in control iPSCs. These data indicate that inefficient protein synthesis contributes to the progressive and deteriorating phenotypes in patients with the p.R756C variant among a variety of ATP1A3-related disorders.

Unexpected risk factors of pathological hikikomori during the COVID‐19 pandemic among working adults initially without social isolation: A longitudinal online survey
Kuan‐Lun Huang, Ryoko Katsuki, Taisei Kubo, Jiun‐Yi Wang, Shinji Sakamoto, Tomohiro Nakao, Takahiro A. Kato
Psychiatry and Clinical Neurosciences, Wiley, 28 Feb. 2024
Scientific journal

Could the Construct of Modern-Type Depression Predict Internet Gaming Disorder in Italian Video Gamers? A Case–Control Study
Laura Orsolini, Giulio Longo, Silvia Bellagamba, Takahiro A. Kato, Umberto Volpe
Brain Sciences, 14, 1, 48, 48, MDPI AG, 03 Jan. 2024
Scientific journal, A new postmodern depression type, named “Modern-Type Depression” (MTD), is emerging in Western countries. MTD is often underdiagnosed, mainly due to potentially higher comorbidity with technology-based addictions, including Internet Gaming Disorder (IGD). However, the definition of the relationship between MTD and IGD is still controversial, as few data have been published thus far. In particular, there are no data specifically investigating the prevalence of MTD within Italian young subjects with IGD, as well as their mutual association. Hence, within the SWATCH (Social Withdrawal and TeCno-mediated mental Health issues) project, our study aimed to identify the prevalence of MTD in a sample of Italian young adults who play video games by providing a clinical characterization of MTD within a group of IGD individuals (IGD+) versus a group without IGD (IGD−) who play video games. Our cross-sectional case–control study recruited a sample of 543 Italian young video-gaming players (aged 18–35) from the larger SWATCH database, stratified as IGD+ versus IGD−. Subjects were administered the 22-item Tarumi’s Modern-Type Depression Trait Scale (TACS-22), the Motives for Online Gaming Questionnaire (MOGQ), and the Internet Gaming Disorder Scale-Short Form (IGDS9-SF). Around 21.7% of the total sample was represented by MTD individuals, while within the IGD sample, around 34% of subjects had MTD. Within the MTD group, significantly higher scores at IGDS-9SF (p < 0.001), MOGQ “Escape from reality” (p < 0.001), “Fantasy” (p < 0.001), and MOGQ total score (p = 0.003) were found compared to MTD−. According to the multivariate regression model, controlled for sex and age, higher scores in the TACS-22 were positively predicted by the total score of IGDS9-SF (p = 0.003), the MOGQ “Escape from Reality” subscale (p = 0.014), and MOGQ “Fantasy” (p = 0.011), and negatively predicted by the MOGQ “Competition” subscale (p = 0.035) [F (4538) = 17.265; p < 0.001]. Our findings suggested that MTD displays a strong association with IGD. Video-gaming players who do not have IGD appear to be less prone to MTD; this suggests that further studies could be carried out to specifically investigate whether pathological use of video games could also be determined by the presence of MTD.

Heterogeneity of gaming disorder: A clinically-based typology for developing personalized interventions
Chih-Hung Ko, Orsolya Király, Zsolt Demetrovics, Mark D. Griffiths, Takahiro A. Kato, Masaru Tateno, Ju-Yu Yen
Journal of Behavioral Addictions, 12, 4, 855, 861, Akademiai Kiado Zrt., 22 Dec. 2023, [Peer-reviewed]
Scientific journal, Abstract

Background

The eleventh revision of the International Classification of Diseases (ICD-11) defines the three key diagnostic criteria for gaming disorder (GD). These are loss of control over gaming, gaming as a priority over daily activities, and impaired functioning due to gaming. While this definition has implications for the prevention and treatment of GD, there is significant heterogeneity in the symptoms and etiology of GD among individuals, which results in different treatment needs. Cognitive control, emotional regulation, and reward sensitivity are three critical dimensions in the etiology model for GD. Aspects such as gender, comorbidity, motivation for gaming, stage or severity of GD, and risk factors all contribute to the heterogeneity of etiology among individuals with the disorder.

Method

On the basis of clinical symptoms and comorbidity characteristics among approximately 400 patients with gaming disorder, the present paper proposes a clinical typology of patients with GD based on the authors' clinical experience in treating individuals with GD.

Results

The findings indicated three common types of patients with GD: (i) impulsive male patients with attention deficit hyperactivity disorder (ADHD), (ii) dysphoria patients with dysfunctional coping skills, and (iii) isolated patients with social anxiety. The paper also discusses the presentation and treatment priority for these patients.

Conclusion

Personalized treatments for patients with GD should be developed to fit their individual needs. Future studies should examine the heterogeneity of GD and confirm these types, as well as obtain evidence-based information that can help in the development of personalized treatment. Treatment resources should be developed, and professionals should be trained to provide integrated individualized treatment.

Youth hikikomori-like social withdrawal in Italy: Two clinical cases
Laura Orsolini, Silvia Bellagamba, Giulio Longo, Umberto Volpe, Takahiro A. Kato
Psychiatry Research Case Reports, 2, 2, 100179, 100179, Elsevier BV, Dec. 2023, [Peer-reviewed]
Scientific journal

Hikikomori and gaming disorder tendency: A case‐control online survey for nonworking adults
Taisei Kubo, Kazumasa Horie, Toshio Matsushima, Masaru Tateno, Toshihide Kuroki, Tomohiro Nakao, Takahiro A Kato
Psychiatry and Clinical Neurosciences, 78, 1, 77, 78, Wiley, 27 Nov. 2023, [Peer-reviewed]
Scientific journal

Effects of melatonin on dopaminergic neuron development via IP3-mediated mitochondrial Ca2+ regulation in autism spectrum disorder
Shuangshan Dong, Takashi Kifune, Hiroki Kato, Lu Wang, Jun Kong, Yuta Hirofuji, Xiao Sun, Hiroshi Sato, Yosuke Ito, Takahiro A. Kato, Yasunari Sakai, Shouichi Ohga, Satoshi Fukumoto, Keiji Masuda
Biochemical and Biophysical Research Communications, 681, 7, 12, Elsevier BV, Nov. 2023, [Peer-reviewed]
Scientific journal

Editorial: Hikikomori: an international perspective on assessment, treatment, and community intervention
T. Wing Lo, John C. M. Wong, Gloria Hongyee Chan, Takahiro A. Kato
Frontiers in Psychiatry, 14, Frontiers Media SA, 18 Oct. 2023, [Peer-reviewed]
Scientific journal

Psychopathological Characteristics of Modern Type Depression　　　　　　　　　　　　　　　
Je SR, An YW, Kato TA, Choi TY
Journal of the Korean Society of Biological Therapies in Psychiatry(Korean language), 29, 3, 61, 67, Oct. 2023

Heterogeneity and mitochondrial vulnerability configurate the divergent immunoreactivity of human induced microglia-like cells
Kousuke Yonemoto, Fumihiko Fujii, Ryoji Taira, Masahiro Ohgidani, Katsuhide Eguchi, Sayaka Okuzono, Yuko Ichimiya, Yuri Sonoda, Pin Fee Chong, Hironori Goto, Hikaru Kanemasa, Yoshitomo Motomura, Masataka Ishimura, Yuhki Koga, Keita Tsujimura, Takao Hashiguchi, Hiroyuki Torisu, Ryutaro Kira, Takahiro A. Kato, Yasunari Sakai, Shouichi Ohga
Clinical Immunology, 255, 109756, 109756, Elsevier BV, Oct. 2023, [Peer-reviewed]
Scientific journal

The Hikikomori Diagnostic Evaluation (HiDE): a proposal for a structured assessment of pathological social withdrawal
Alan R. Teo, Kazumasa Horie, Keita Kurahara, Takahiro A. Kato
World Psychiatry, 22, 3, 478, 479, Wiley, 15 Sep. 2023, [Peer-reviewed], [Last author, Corresponding author]
Scientific journal

Angiogenic and inflammatory responses in human induced microglia-like (iMG) cells from patients with Moyamoya disease
Noritoshi Shirozu, Masahiro Ohgidani, Nobuhiro Hata, Shunya Tanaka, Shogo Inamine, Noriaki Sagata, Tetsuaki Kimura, Ituro Inoue, Koichi Arimura, Akira Nakamizo, Ataru Nishimura, Naoki Maehara, Soh Takagishi, Katsuma Iwaki, Tomohiro Nakao, Keiji Masuda, Yasunari Sakai, Masahiro Mizoguchi, Koji Yoshimoto, Takahiro A. Kato
Scientific Reports, 13, 1, Springer Science and Business Media LLC, 08 Sep. 2023, [Peer-reviewed]
Scientific journal, Abstract

Angiogenic factors associated with Moyamoya disease (MMD) are overexpressed in M2 polarized microglia in ischemic stroke, suggesting that microglia may be involved in the pathophysiology of MMD; however, existing approaches are not applicable to explore this hypothesis. Herein we applied blood induced microglial-like (iMG) cells. We recruited 25 adult patients with MMD and 24 healthy volunteers. Patients with MMD were subdivided into progressive (N = 7) or stable (N = 18) group whether novel symptoms or radiographic advancement of Suzuki stage within 1 year was observed or not. We produced 3 types of iMG cells; resting, M1-, and M2-induced cells from monocytes, then RNA sequencing followed by GO and KEGG pathway enrichment analysis and qPCR assay were performed. RNA sequencing of M2-induced iMG cells revealed that 600 genes were significantly upregulated (338) or downregulated (262) in patients with MMD. Inflammation and immune-related factors and angiogenesis-related factors were specifically associated with MMD in GO analysis. qPCR for MMP9, VEGFA, and TGFB1 expression validated these findings. This study is the first to demonstrate that M2 microglia may be involved in the angiogenic process of MMD. The iMG technique provides a promising approach to explore the bioactivity of microglia in cerebrovascular diseases.

Analyzing changes in help-seeking from mental and physical health professionals during COVID-19 in Japan
Shinji Sakamoto, Yudai Suzuki, Ryoko Katsuki, Itsuki Yamakawa, Takahiro A. Kato
Psychology, Health & Medicine, 1, 13, Informa UK Limited, 03 Sep. 2023, [Peer-reviewed]
Scientific journal

Hikikomori: A perspective from bibliometric analysis
Hong Cai, Sha Sha, Qinge Zhang, Tong Leong Si, Yu‐Fei Liu, Wan‐Ying Zheng, Zhaohui Su, Teris Cheung, Gabor S. Ungvari, Alan R. Teo, Takahiro A. Kato, Chee H. Ng, Yu‐Tao Xiang
Psychiatry and Clinical Neurosciences, 77, 10, 541, 549, Wiley, 03 Aug. 2023, [Peer-reviewed]
Scientific journal, Aims

Hikikomori is a common phenomenon reported in Japan and many other countries. However, the broad trends of the research publications on hikikomori are unclear. Therefore, this study examined the patterns of research on hikikomori using bibliometric analysis.

Methods

Relevant publications were searched in Web of Science. Bibliometric analyses were performed with CiteSpace, R and VOSviewer.

Results

In total, 297 publications on hikikomori met the eligibility criteria. The International Journal of Social Psychiatry (IF = 10.461) published the most papers (K = 17, or 5.7%) on hikikomori. Takahiro A. Kato from Kyushu University (41; 13.8%; H‐index = 18) was the most influential author, while Takahiro A. Kato (total link strength [TLS]: 235), Alan R. Teo (TLS: 157), and Masaru Tateno (TLS: 153) separately had the strongest research collaboration with other researchers. Of all countries that published on hikikomori, Japan had the highest number of publications (K = 91). The keywords “United States” and “psychiatric diagnosis” received the most attention between 2013 and 2015, whereas “health” and “autism spectrum disorder” received the most attention in 2021 and 2022.

Conclusions

Peer‐reviewed research publications on hikikomori are growing rapidly and the research trends in this field are also changing.

Shank3a/b isoforms regulate the susceptibility to seizures and thalamocortical development in the early postnatal period of mice
Sayaka Okuzono, Fumihiko Fujii, Yuki Matsushita, Daiki Setoyama, Yohei Shinmyo, Ryoji Taira, Kousuke Yonemoto, Satoshi Akamine, Yoshitomo Motomura, Masafumi Sanefuji, Takeshi Sakurai, Hiroshi Kawasaki, Kihoon Han, Takahiro A. Kato, Hiroyuki Torisu, Dongchon Kang, Yusaku Nakabeppu, Yasunari Sakai, Shouichi Ohga
Neuroscience Research, 193, 13, 19, Elsevier BV, Aug. 2023, [Peer-reviewed]
Scientific journal

Ameliorative effects of Fingolimod (FTY720) on microglial activation and psychosis-related behavior in short term cuprizone exposed mice
Siyao Li, Koki Sakurai, Masahiro Ohgidani, Takahiro A. Kato, Takatoshi Hikida
Molecular Brain, 16, 1, Springer Science and Business Media LLC, 12 Jul. 2023, [Peer-reviewed]
Scientific journal, Abstract

Schizophrenia is a psychiatric disorder that affects around 1% of the population in widespread populations, with severe cases leading to long-term hospitalization and necessitation of lifelong treatment. Recent studies on schizophrenia have highlighted the involvement of inflammatory and immunoregulatory mechanisms with the onset of symptoms, and the usage of anti-inflammatory treatments are being tested against periods of rapid psychosis. In the central nervous system, microglia are the innate immune population which are activated in response to a wide range of physical and psychological stress factors and produce proinflammatory mediators such as cytokines. Microglial activation and neuroinflammation has been associated to numerous psychiatric disorders including schizophrenia, especially during psychotic episodes. Thus, novel treatments which dampen microglial activation may be of great relevance in the treatment of psychiatric disorders. Fingolimod (FTY720) is a drug used as an immunosuppressive treatment to multiple sclerosis. Recent clinical trials have focused on FTY720 as a treatment for the behavioral symptoms in schizophrenia. However, the mechanisms of Fingolimod in treating the symptoms of schizophrenia are not clear. In this study we use a recently developed neuroinflammatory psychosis model in mice: cuprizone short-term exposure, to investigate the effects of FTY720 administration. FTY720 administration was able to completely alleviate methamphetamine hypersensitivity caused by cuprizone exposure. Moreover, administration of FTY720 improved multiple measures of neuroinflammation (microglial activation, cytokine production, and leucocyte infiltration). In conclusion, our results highlight the future use of FTY720 as a direct anti-inflammatory treatment against microglial activation and psychosis.

Holiday Internet Usage Time and the Risk of Internet Addiction Tendency among Working Adults in their 30s in Japan
Keitaro Matsuo, Masaru Tateno, Ryoko Katsuki, Tomohiro Nakao, Takahiro A. Kato
Psychiatry International, 4, 3, 200, 207, MDPI AG, 12 Jul. 2023, [Peer-reviewed]
Scientific journal, Introduction: A positive association between Internet usage time and Internet addiction among adolescents and adults has been frequently reported; however, studies of working adults focusing on weekdays and holidays are limited. Therefore, this study aimed to elucidate the association between Internet usage time and psychometric tests among working adults in their 30s, focusing on weekdays and holidays. Methods: A total of 129 workers aged 30–39 years participated in this study. Participants completed a questionnaire and interview regarding psychometric tests, including Internet usage time, Internet addiction tendency, smartphone addiction tendency, depression tendency, and personality traits. A correlation analysis focusing on differences between weekdays and holidays was conducted. Results: The scores on Internet addiction scales are weakly positively correlated with holiday Internet usage time. The scores of smartphone addiction scales are also weakly positively correlated with the holiday Internet time. No correlation was found between weekdays Internet usage time and scores on Internet addiction scales. Conclusions: Internet usage time during holidays is associated with Internet addiction tendency among the working adult samples. Holiday Internet usage time could be a useful indicator of risk of Internet addiction. Our pilot findings provide clues to the mental health affected by the Internet, especially among adults.

Clinical use of mood stabilizers beyond treatment for bipolar disorder: The REAP-MS study
Chih-Ken Chen, Shu-Yu Yang, Seon-Cheol Park, Ok-Jin Jang, Xiaomin Zhu, Yu-Tao Xiang, Wen-Chen Ouyang, Afzal Javed, M. Nasar Sayeed Khan, Sandeep Grover, Ajit Avasthi, Roy Abraham Kallivayalil, Kok Yoon Chee, Norliza Chemi, Takahiro A. Kato, Kohei Hayakawa, Pornjira Pariwatcharakul, Margarita Maramis, Lakmi Seneviratne, Kang Sim, Wai Kwong Tang, Tin Oo, Norman Sartorius, Chay-Hoon Tan, Mian-Yoon Chong, Yong Chon Park, Naotaka Shinfuku, Shih-Ku Lin
Asian Journal of Psychiatry, 85, 103613, 103613, Elsevier BV, Jul. 2023, [Peer-reviewed]
Scientific journal

Hikikomori‐like social withdrawal: An Italian case report
Laura Orsolini, Giulio Longo, Silvia Bellagamba, Takahiro A. Kato, Umberto Volpe
Psychiatry and Clinical Neurosciences, 77, 9, 510, 510, Wiley, 23 Jun. 2023, [Peer-reviewed]
Scientific journal

High‐sensitivity C‐reactive protein and bilirubin as possible biomarkers for hikikomori in depression: a case–control study
Sota Kyuragi, Toshio Matsushima, Matsuo Keitaro, Tomohiro Nakao, Takahiro A Kato
Psychiatry and Clinical Neurosciences, 77, 8, 458, 460, Wiley, 11 May 2023, [Peer-reviewed]
Scientific journal

Clozapine Use for Bipolar Disorder
Lek Wei Javier Loo, Qian Hui Chew, Shih-Ku Lin, Su-Yu Yang, Wen-Chen Ouyang, Chih-Ken Chen, Seon-Cheol Park, Ok-Jin Jang, Jun Hyuk Park, Kok-Yoon Chee, Kwong Sen Ding, Jamaline Chong, Ling Zhang, Keqing Li, Xiaomin Zhu, Chonnakarn Jatchavala, Pornjira Pariwatcharakul, Roy A. Kallivayalil, Sandeep Grover, Ajit Avasthi, Moin Ansari, Margarita M. Maramis, Paing Phyo Aung, Norman Sartorius, Yu-Tao Xiang, Chay-Hoon Tan, Mian-Yoon Chong, Yong Chon Park, Takahiro A. Kato, Naotaka Shinfuku, Ross J. Baldessarini, Kang Sim
Journal of Clinical Psychopharmacology, 43, 3, 278, 282, Ovid Technologies (Wolters Kluwer Health), May 2023, [Peer-reviewed]
Scientific journal

Pathological social withdrawal in autism spectrum disorder: A case control study of hikikomori in Japan
Mari Yamada, Takahiro A. Kato, Ryoko Inoue Katsuki, Hideki Yokoi, Miki Igarashi, Yoko Komine, Yukinori Kamata, Nobumasa Kato, Akira Iwanami, Haruhisa Ohta
Frontiers in Psychiatry, 14, Frontiers Media SA, 23 Mar. 2023, [Peer-reviewed]
Scientific journal, Introduction

Hikikomori, a form of pathological social withdrawal, has been suggested to have comorbidity with autism spectrum disorder (ASD). This study aimed to clarify how characteristics of ASD are associated with hikikomori.

Methods

Thirty-nine adult male patients with a diagnosis of ASD attending our outpatient clinic for neurodevelopmental disabilities were subjected to a structured interview regarding social withdrawal, various self-administered questionnaires, and blood tests. Through structured interviews, the subjects were divided into two groups: (Group 1) ASD with hikikomori condition and (Group 2) ASD without hikikomori condition. Sixteen subjects qualified as hikikomori and 23 subjects qualified as subjects without hikikomori. Age, sex, autism spectrum quotient (AQ), Autism Diagnostic Observation Schedule (ADOS), and FIQ were matched.

Results

Compared to non-hikikomori controls, hikikomori cases were likely to have stronger sensory symptoms, lower uric acid (UA) (p = 0.038), and higher rates of atopic dermatitis (p = 0.01). Cases showed more severe depressive and social anxiety symptoms based on self-rated scales: Patient Heath Questionnaire 9 (PHQ-9) (p &lt; 0.001) and Liebowitz Social Anxiety Scale Japanese Version (LSAS-J) (p = 0.04). Tarumi's Modern-Type Depression Trait Scale (TACS-22), which measure traits of Modern-Type Depression (MTD), were significantly higher in cases (p = 0.003).

Conclusion

The present study has suggested that ASD patients with hikikomori were more likely to have higher sensory abnormalities, comorbid atopic dermatitis, lower UA, stronger depressive, and anxiety tendency. Evaluating and approaching these aspects are important for appropriate interventions in ASD with hikikomori. Further investigations should be conducted to validate our pilot findings.

Clinical Usefulness of a Short Version of the Internet Addiction Test to Screen for Probable Internet Addiction in Adolescents with Autism Spectrum Disorder
Masaru Tateno, Kazumasa Horie, Tomohiro Shirasaka, Kotaro Nanba, Eri Shiraishi, Yukie Tateno, Takahiro A. Kato
International Journal of Environmental Research and Public Health, 20, 5, 4670, 4670, MDPI AG, 06 Mar. 2023, [Peer-reviewed]
Scientific journal, Internet addiction (IA) is defined as the condition of being addicted to all sorts of activities on the Internet. Individuals with neurodevelopmental disorders, including autism spectrum disorder (ASD), may be susceptible to IA. Early detection and intervention for probable IA are important to prevent severe IA. In this study, we investigated the clinical usefulness of a short version of the Internet Addiction Test (s-IAT) for the screening of IA among autistic adolescents. The subjects were 104 adolescents with a confirmed diagnosis of ASD. They were requested to answer 20 questions from the original Internet Addiction Test (IAT). In the data analysis process, we comparatively calculated the sum of scores to the 12 questions of s-IAT. In total, 14 of the 104 subjects were diagnosed as having IA based on the face-to-face clinical interview that was regarded as the gold standard. Statistical analysis suggested that the optimal cut-off for s-IAT was at 35. When we applied the cut-off of 70 on the IAT, only 2 of 14 subjects (14.3%) with IA were screened positive, whereas 10 (71.4%) of them were screened by using the cut-off point of 35 on s-IAT. The s-IAT might be useful for the screening of IA in adolescents with ASD.

Interferon signaling and hypercytokinemia-related gene expression in the blood of antidepressant non-responders
Hirotaka Yamagata, Ryouichi Tsunedomi, Toshiharu Kamishikiryo, Ayumi Kobayashi, Tomoe Seki, Masaaki Kobayashi, Kosuke Hagiwara, Norihiro Yamada, Chong Chen, Shusaku Uchida, Hiroyuki Ogihara, Yoshihiko Hamamoto, Go Okada, Manabu Fuchikami, Jun-ichi Iga, Shusuke Numata, Makoto Kinoshita, Takahiro A. Kato, Ryota Hashimoto, Hiroaki Nagano, Shuichi Ueno, Yasumasa Okamoto, Tetsuro Ohmori, Shin Nakagawa
Heliyon, 9, 1, e13059, e13059, Elsevier BV, Jan. 2023, [Peer-reviewed]
Scientific journal

The factor structure of extrapyramidal symptoms evaluated using the Drug‐Induced Extrapyramidal Symptoms Scale in patients with schizophrenia: Results from the 2016 REAP AP‐4 study
Chika Kubota, Toshiya Inada, Shih‐Ku Lin, Ajit Avasthi, Kok Yoon Chee, Andi Jayalangkara Tanra, Shu‐Yu Yang, Lian‐Yu Chen, Mian‐Yoon Chong, Adarsh Tripathi, Roy Abraham Kallivayalil, Sandeep Grover, Seon‐Cheol Park, Takahiro A. Kato, Yu‐Tao Xiang, Kang Sim, Margarita M. Maramis, Isa Multazam Noor, Chay‐Hoon Tan, Norman Sartorius, Naotaka Shinfuku
Human Psychopharmacology: Clinical and Experimental, 38, 2, Wiley, 03 Dec. 2022, [Peer-reviewed]
Scientific journal, Abstract

Introduction

Drug‐induced extrapyramidal syndrome (EPS) remains a major problem in clinical psychiatry. This study aimed to examine the factor structure of drug‐induced extrapyramidal symptoms observed in patients with schizophrenia and assessed using the Drug‐Induced Extrapyramidal Symptoms Scale (DIEPSS).

Methods

The participants were 1478 patients with a diagnosis of schizophrenia whose EPS was assessed using the DIEPSS in India, Indonesia, Japan, Malaysia, and Taiwan in the 2016 REAP AP‐4 study. The records of the participants were randomly divided into two subgroups: the first for exploratory factor analysis of the eight DIEPSS items, and the second for confirmatory factor analysis.

Results

The factor analysis identified three factors: F1 (gait and bradykinesia), F2 (muscle rigidity and tremor), and F3 (sialorrhea, akathisia, dystonia, and dyskinesia).

Conclusion

The results suggest that the eight individual items of the DIEPSS could be composed of three different mechanisms: acute parkinsonism observed during action (F1), acute parkinsonism observed at rest (F2), and central dopaminergic mechanisms with pathophysiology other than acute parkinsonism (F3).

One month version of Hikikomori Questionnaire‐25 ( HQ‐25M ): Development and initial validation.
Takahiro A. Kato, Yudai Suzuki, Kazumasa Horie, Alan R. Teo, Shinji Sakamoto
Psychiatry and Clinical Neurosciences, 77, 3, 188, 189, Wiley, 29 Nov. 2022, [Peer-reviewed]
Scientific journal

A case of bipolar disorder with AIF1 (coding gene of Iba‐1) deletion: A pilot in vitro analysis using blood‐derived microglia‐like cells
Masahiro Ohgidani, Itaru Kushima, Shogo Inamine, Sota Kyuragi, Noriaki Sagata, Tomohiro Nakao, Shigenobu Kanba, Norio Ozaki, Takahiro A Kato
Psychiatry and Clinical Neurosciences, 77, 2, 128, 130, Wiley, 24 Nov. 2022, [Peer-reviewed]
Scientific journal

Preliminary analysis of hippocampus synaptic apoptosis and microglial phagocytosis induced by severe restraint stress
Shingo Enomoto, Masahiro Ohgidani, Noriaki Sagata, Shogo Inamine, Takahiro A. Kato
Neuropsychopharmacology Reports, 43, 1, 120, 125, Wiley, 23 Nov. 2022, [Peer-reviewed]
Scientific journal

Sex-differences in hikikomori traits as predictors of problematic internet use in Italian university students
Laura Orsolini, Imran Gokcen Yılmaz-Karaman, Giulio Longo, Silvia Bellagamba, Takahiro A. Kato, Umberto Volpe
Journal of Psychiatric Research, 155, 211, 218, Elsevier BV, Nov. 2022, [Peer-reviewed]
Scientific journal

Personality traits of female vocational school students in Japan with smartphone addiction with comorbid modern‐type depression traits
Masaru Tateno, Takahiro A. Kato
Psychiatry and Clinical Neurosciences, Wiley, 19 Oct. 2022, [Peer-reviewed]
Scientific journal

Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder
Itaru Kushima, Masahiro Nakatochi, Branko Aleksic, Takashi Okada, Hiroki Kimura, Hidekazu Kato, Mako Morikawa, Toshiya Inada, Kanako Ishizuka, Youta Torii, Yukako Nakamura, Satoshi Tanaka, Miho Imaeda, Nagahide Takahashi, Maeri Yamamoto, Kunihiro Iwamoto, Yoshihiro Nawa, Nanayo Ogawa, Shuji Iritani, Yu Hayashi, Tzuyao Lo, Gantsooj Otgonbayar, Sho Furuta, Nakao Iwata, Masashi Ikeda, Takeo Saito, Kohei Ninomiya, Tomo Okochi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kenichiro Miura, Masanari Itokawa, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Kazutaka Ohi, Toshiki Shioiri, Kiyoyuki Kitaichi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Tsukasa Sasaki, Mamoru Tochigi, Fumichika Nishimura, Hidenori Yamasue, Hitoshi Kuwabara, Tomoyasu Wakuda, Takahiro A. Kato, Shigenobu Kanba, Hideki Horikawa, Masahide Usami, Masaki Kodaira, Kyota Watanabe, Takeo Yoshikawa, Tomoko Toyota, Shigeru Yokoyama, Toshio Munesue, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Minyoung Jung, Kiyoto Kasai, Tempei Ikegame, Seiichiro Jinde, Shusuke Numata, Makoto Kinoshita, Tadafumi Kato, Chihiro Kakiuchi, Kazuhiro Yamakawa, Toshimitsu Suzuki, Naoki Hashimoto, Shuhei Ishikawa, Bun Yamagata, Shintaro Nio, Toshiya Murai, Shuraku Son, Yasuto Kunii, Hirooki Yabe, Masumi Inagaki, Yu-ichi Goto, Yuto Okumura, Tomoya Ito, Yuko Arioka, Daisuke Mori, Norio Ozaki
Biological Psychiatry, 92, 5, 362, 374, Elsevier BV, Sep. 2022, [Peer-reviewed]
Scientific journal

A network analysis of problematic smartphone use in Japanese young adults
Masaru Tateno, Takahiro A. Kato, Tomohiro Shirasaka, Junichiro Kanazawa, Wataru Ukai, Tomoya Hirota
PLOS ONE, 17, 8, e0272803, e0272803, Public Library of Science (PLoS), 08 Aug. 2022, [Peer-reviewed]
Scientific journal, Background

We aimed to explore the overall network structure of problematic smartphone use symptoms assessed by smartphone addiction scale-short version (SAS-SV) and to identify which items could play important roles in the network.

Methods

487 college and university students filled out the study questionnaire, including SAS-SV. We constructed a regularized partial correlation network among the 10 items of SAS-SV. We calculated three indices of node centrality: strength, closeness, and betweenness, to quantify the importance of each SAS-SV item.

Results

We identified 34 edges in the estimated network. In the given network, one item pertaining to withdrawal symptom hadthe highest strength and high closeness centrality. Additionally, one item related to preoccupation was also found to have high centrality indices.

Conclusion

Our results indicating the central role of one withdrawal symptom and one preoccupation symptom in the symptom network of problematic smartphone use in young adults were in line with a previous study targeting school-age children. Longitudinal study designs are required to elicit the role of these central items on the formation and maintenance of this behavioral problem.

Hikikomori and modern-type depression in Italy: A new phenotypical trans-cultural characterization?
Laura Orsolini, Silvia Bellagamba, Umberto Volpe, Takahiro A. Kato
International Journal of Social Psychiatry, 68, 5, 1010, 1017, SAGE Publications, Aug. 2022, [Peer-reviewed]
Scientific journal, Introduction:

Hikikomori is a Japanese term etymologically derived from ‘ hiku’ (i.e. ‘ to pull back’) and ‘ komoru’ (i.e. ‘ seclude oneself’), which identifies those subjects who deliberately withdraw themselves by social life, remaining confined into their own home/room. The phenomenon is widely diffused in Japan, even though it is currently spread outside the Japanese culture. However, a universally shared and cross-cultural adaptation of Hikikomori definition, phenomenological and psychopathological characterization is still missing.

Methodology:

An expert-guided opinion paper was here provided to clinical characterize the Hikikomori-like social withdrawal in the Italian context, by considering the transformation from a family-based society to a ‘fluid’ digital-structured culture, also discussing the concept of modern-type depression. This was provided deepening the principal current studies available in literature and giving an interpretation based on clinical experience in the Italian society. The work was supervised through a consensus by the most international expert of Japanese Hikikomori syndrome.

Results:

Current individual, family and social trajectories may potentially act as a mediator in favouring the occurrence of Hikikomori-like social withdrawal also in western countries, including Italy. Despite the differences between Japanese and Italian society and culture, the recent shaping of family structure and intra-familial dynamics, typical of the current post-modern society, may potentially influence the emergence of psychopathologies not typical of Italian culture. Unemployment and ‘Not in Employment Education or Training’ (NEET) conditions may represent another potential risk factor for economical/social marginalization of youngsters, together with the recent dramatic emergence of web-based psychopathologies.

Conclusion:

A diagnostic culturally-adapted flow-chart is proposed for clinical characterizing Hikikomori in Italian context, which may help in proposing preventive strategies, ensuring early identification and prompt therapeutic interventions, particularly among youngsters.

Risk factors of hikikomori among office workers during the COVID-19 pandemic: A prospective online survey
Hiroaki Kubo, Ryoko Katsuki, Kazumasa Horie, Itsuki Yamakawa, Masaru Tateno, Naotaka Shinfuku, Norman Sartorius, Shinji Sakamoto, Takahiro A. Kato
Current Psychology, Springer Science and Business Media LLC, 29 Jul. 2022, [Peer-reviewed]
Scientific journal, Abstract

The global pandemic of COVID-19 has forced people to restrict their outings. In Japan, self-restraint behavior (SRB) has been requested by the government, and some of those decreasing their outings may shift to pathological social withdrawal; hikikomori. The purpose of this study was to examine the risk factors of hikikomori conducting an online prospective survey. An online survey was conducted in June 2020 and December 2020; (1) SRB-related indicators (degree of SRB, motivation for SRB, stigma and self-stigma toward COVID-19, anxiety and depressive feelings toward COVID-19) and (2) general mental health (hikikomori tendency, depressive symptoms, modern type depression (MTD) tendency, internet addiction) were collected. A cross-lagged effects model was performed to examine the association between these variables. Lack of emotional support and lack of socialization in June 2020 increased isolation in December 2020. Besides, MTD and hikikomori interacted with each other. Interestingly, although hikikomori tendency increased depressive tendencies, SRB itself did not have a significant path on any mental health-related variables. Poor interpersonal relationships, rather than SRB per se, are suggested to be a risk factor for increased isolation among office workers in the COVID-19 pandemic. Appropriate early interventions such as interpersonal or emotional support may prevent the transition to pathological hikikomori. The association between MTD and hikikomori seems to reveal the interesting possibility that MTD is a gateway to increased risk of hikikomori, and that hikikomori is a gateway to MTD as well. Future research is required to elucidate the relationship between hikikomori and MTD.

A Machine-Learning-Algorithm-Based Prediction Model for Psychotic Symptoms in Patients with Depressive Disorder
Kiwon Kim, Je il Ryu, Bong Ju Lee, Euihyeon Na, Yu-Tao Xiang, Shigenobu Kanba, Takahiro A. Kato, Mian-Yoon Chong, Shih-Ku Lin, Ajit Avasthi, Sandeep Grover, Roy Abraham Kallivayalil, Pornjira Pariwatcharakul, Kok Yoon Chee, Andi J. Tanra, Chay-Hoon Tan, Kang Sim, Norman Sartorius, Naotaka Shinfuku, Yong Chon Park, Seon-Cheol Park
Journal of Personalized Medicine, 12, 8, 1218, 1218, MDPI AG, 26 Jul. 2022, [Peer-reviewed]
Scientific journal, Psychotic symptoms are rarely concurrent with the clinical manifestations of depression. Additionally, whether psychotic major depression is a subtype of major depression or a clinical syndrome distinct from non-psychotic major depression remains controversial. Using data from the Research on Asian Psychotropic Prescription Patterns for Antidepressants, we developed a machine-learning-algorithm-based prediction model for concurrent psychotic symptoms in patients with depressive disorders. The advantages of machine learning algorithms include the easy identification of trends and patterns, handling of multi-dimensional and multi-faceted data, and wide application. Among 1171 patients with depressive disorders, those with psychotic symptoms were characterized by significantly higher rates of depressed mood, loss of interest and enjoyment, reduced energy and diminished activity, reduced self-esteem and self-confidence, ideas of guilt and unworthiness, psychomotor agitation or retardation, disturbed sleep, diminished appetite, and greater proportions of moderate and severe degrees of depression compared to patients without psychotic symptoms. The area under the curve was 0.823. The overall accuracy was 0.931 (95% confidence interval: 0.897–0.956). Severe depression (degree of depression) was the most important variable in the prediction model, followed by diminished appetite, subthreshold (degree of depression), ideas or acts of self-harm or suicide, outpatient status, age, psychomotor retardation or agitation, and others. In conclusion, the machine-learning-based model predicted concurrent psychotic symptoms in patients with major depression in connection with the “severity psychosis” hypothesis.

Mitochondrial Calcium-Triggered Oxidative Stress and Developmental Defects in Dopaminergic Neurons Differentiated from Deciduous Teeth-Derived Dental Pulp Stem Cells with MFF Insufficiency
Xiao Sun, Shuangshan Dong, Hiroki Kato, Jun Kong, Yosuke Ito, Yuta Hirofuji, Hiroshi Sato, Takahiro A. Kato, Yasunari Sakai, Shouichi Ohga, Satoshi Fukumoto, Keiji Masuda
Antioxidants, 11, 7, 1361, 1361, MDPI AG, 13 Jul. 2022, [Peer-reviewed]
Scientific journal, Mitochondrial fission factor (MFF) is an adapter that targets dynamin-related protein 1 from the cytosol to the mitochondria for fission. Loss-of-function MFF mutations cause encephalopathy due to defective mitochondrial and peroxisomal fission 2 (EMPF2). To elucidate the molecular mechanisms that were involved, we analyzed the functional effects of MFF depletion in deciduous teeth-derived dental pulp stem cells differentiating into dopaminergic neurons (DNs). When treated with MFF-targeting small interfering RNA, DNs showed impaired neurite outgrowth and reduced mitochondrial signals in neurites harboring elongated mitochondria. MFF silencing also caused mitochondrial Ca2+ accumulation through accelerated Ca2+ influx from the endoplasmic reticulum (ER) via the inositol 1,4,5-trisphosphate receptor. Mitochondrial Ca2+ overload led DNs to produce excessive reactive oxygen species (ROS), and downregulated peroxisome proliferator-activated receptor-gamma co-activator-1 alpha (PGC-1α). MFF was co-immunoprecipitated with voltage-dependent anion channel 1, an essential component of the ER-mitochondrial Ca2+ transport system. Folic acid supplementation normalized ROS levels, PGC-1α mediated mitochondrial biogenesis, and neurite outgrowth in MFF depleted DNs, without affecting their mitochondrial morphology or Ca2+ levels. We propose that MFF negatively regulates the mitochondrial Ca2+ influx from the ER. MFF-insufficiency recapitulated the EMPF2 neuropathology with increased oxidative stress and suppressed mitochondrial biogenesis. ROS and mitochondrial biogenesis might be potential therapeutic targets for EMPF2.

Changes in the metabolites of cerebrospinal fluid induced by rTMS in treatment-resistant depression: A pilot study
Hiroshi Tateishi, Daiki Setoyama, Takahiro A Kato, Dongchon Kang, Jun Matsushima, Kojiro Nogami, Seiji Mawatari, Ryohei Kojima, Yuka Fujii, Yuta Sakemura, Takumi Shiraishi, Yoshiomi Imamura, Toshihiko Maekawa, Toyoko Asami, Yoshito Mizoguchi, Akira Monji
Psychiatry Research, 313, 114636, 114636, Elsevier BV, Jul. 2022, [Peer-reviewed]
Scientific journal

Dopamine‐related oxidative stress and mitochondrial dysfunction in dopaminergic neurons differentiated from deciduous teeth‐derived stem cells of children with Down syndrome
Xiao Sun, Hiroki Kato, Hiroshi Sato, Xu Han, Yuta Hirofuji, Takahiro A. Kato, Yasunari Sakai, Shouichi Ohga, Satoshi Fukumoto, Keiji Masuda
FASEB BioAdvances, 4, 7, 454, 467, Wiley, Jul. 2022
Scientific journal

Blood metabolic signatures of hikikomori, pathological social withdrawal
Daiki Setoyama, Toshio Matsushima, Kohei Hayakawa, Tomohiro Nakao, Shigenobu Kanba, Dongchon Kang, Takahiro A. Kato
Dialogues in Clinical Neuroscience, 23, 1, 14, 28, Informa UK Limited, 01 Jun. 2022
Scientific journal

Dosing of Mood Stabilizers for Bipolar Disorder Patients in the Research on Asian Psychotropic Prescription Patterns Consortium Study
Yuxi Wang, Qian Hui Chew, Shih-Ku Lin, Shu-Yu Yang, Wen-Chen Ouyang, Chih-Ken Chen, Seon-Cheol Park, Ok-Jin Jang, Jun Hyuk Park, Kok-Yoon Chee, Kwong Sen Ding, Jamaline Chong, Ling Zhang, Keqing Li, Xiaomin Zhu, Chonnakarn Jatchavala, Pornjira Pariwatcharakul, Roy Abraham Kallivayalil, Sandeep Grover, Ajit Avasthi, Moin Ansari, Margarita M. Maramis, Paing Phyo Aung, Norman Sartorius, Yu-Tao Xiang, Chay-Hoon Tan, Mian-Yoon Chong, Yong Chon Park, Takahiro A. Kato, Naotaka Shinfuku, Ross J. Baldessarini, Kang Sim
Journal of Clinical Psychopharmacology, Publish Ahead of Print, Ovid Technologies (Wolters Kluwer Health), 05 Apr. 2022, [Peer-reviewed]
English, Scientific journal

Prescription Patterns for Bipolar Disorder in Asian Countries: Findings from Research on Asian Prescription Pattern-Bipolar Disorder
Shih-Ku Lin, Shu-Yu Yang, Seon-Cheol Park, Ok-Jin Jang, Xiaomin Zhu, Yu-Tao Xiang, Wen-Chen Ouyang, Afzal Javed, M. Nasar Sayeed Khan, Sandeep Grover, Ajit Avasthi, Roy Abraham Kallivayalil, Kok Yoon Chee, Norliza Chemi, Takahiro A. Kato, Kohei Hayakawa, Pornjira Pariwatcharakul, Margarita Maramis, Lakmi Seneviratne, Sim Kang, Wai Kwong Tang, Tin Oo, Norman Sartorius, Chay-Hoon Tan, Mian-Yoon Chong, Yong Chon Park, Naotaka Shinfuku
Clinical Psychopharmacology and Neuroscience, 20, 1, 61, 69, Korean College of Neuropsychopharmacology, 28 Feb. 2022, [Peer-reviewed]
English, Scientific journal

Psychological Traits of Patients With Depression Comorbid With Chronic Pain: Are Complaint and Competitive Tendency Related to Pain?
Koji Fujimoto, Masako Hosoi, Ryoko Katsuki, Toshio Matsushima, Keitaro Matsuo, Tomohiro Nakao, Nobuyuki Sudo, Takahiro A. Kato
Frontiers in Psychiatry, 13, 825422, 825422, Frontiers Media SA, 10 Feb. 2022, [Peer-reviewed]
English, Scientific journal, Background

Modern-Type Depression (MTD) is a category of depression that has been studied mainly in Japan; however, no study has attempted to determine its relation to chronic pain.

Aim

To determine possible associations between psychological traits related to MTD and the chronic pain of patients at psychiatric clinics.

Method

Two hundred and twenty-one first time patients who visited the psychiatric clinic at a Japanese university medical center or an associated clinic were enrolled. The Hamilton Depression Rating Scale was used to measure depressive symptoms. The 22-item Tarumi's Modern-Type Depression Trait Scale (TACS-22), Achievement Motive, and 20-item Toronto Alexithymia Scale were used to assess psychological traits related to depression and chronic pain. The clinical diagnosis of each patient was confirmed by use of the Structured Clinical Interview for DSM-IV Axis I Disorders, administered by experienced specialists. The medians of the psychological traits identified were compared between patients with or without chronic pain. Analysis was also done of patients with Major Depressive Disorder (MDD).

Result

Of the 221 patients, 139 had chronic pain. Patients with chronic pain had more severe depressive symptoms, Alexithymia, and high scores for the complaint trait of MTD. Seventy-three of the 221 patients met the criteria for MDD (53 had chronic pain). Patients with MDD comorbid with chronic pain had a higher competitive achievement score, severe depression, and difficulty identifying feelings.

Conclusion

Complaint and competitive traits were shown to be related to chronic pain in psychiatric settings. Further study will allow us to design multidimensional approach for patients suffering from depression.

Low-Density Lipoprotein Cholesterol Is a Possible Blood Biomarker of Schizoid Personality Traits among Females
Kohei Hayakawa, Motoki Watabe, Hideki Horikawa, Mina Sato-Kasai, Norihiro Shimokawa, Tomohiro Nakao, Takahiro A. Kato
Journal of Personalized Medicine, 12, 2, 131, 131, MDPI AG, 19 Jan. 2022, [Peer-reviewed]
English, Scientific journal, Lower serum levels of low-density lipoprotein cholesterol (LDL-C) have been suggested to indicate higher suicide risk and various psychiatric symptoms. Previously, we reported that lower serum LDL-C levels are associated with loneliness, social phobia, isolated life with little social support, and lower trust in others among young non-clinical females. Thus, we hypothesize that schizoid personality traits may be associated with lower serum LDL-C. We here verified this hypothesis using non-clinical data and clinical data with schizophrenia. Using the database from the Midlife in Japan (MIDJA), a cohort of residents living in Tokyo, we analyzed whether schizoid-related interpersonal characteristics were associated with LDL-C. In addition, we assessed the association between blood biomarkers including LDL-C and schizoid personality traits in 101 adult non-clinical volunteers. Finally, we evaluated the interaction between LDL-C and social decision making of patients with schizophrenia. In female non-clinical volunteers, serum LDL-C level was a predictive factor and negatively correlated with schizoid personality traits. Female patients with schizophrenia, whose serum LDL-C levels were lower, tended not to trust other females. The present findings suggest that LDL-C may influence schizoid personality traits in females, which provide a basis for further investigation into the biological aspects of schizoid personality disorder.

Network Analysis-Based Disentanglement of the Symptom Heterogeneity in Asian Patients with Schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics
Joonho Choi, Hyung-Jun Yoon, Jae Hong Park, Yukako Nakagami, Chika Kubota, Toshiya Inada, Takahiro A. Kato, Shu-Yu Yang, Sih-Ku Lin, Mian-Yoon Chong, Ajit Avasthi, Sandeep Grover, Roy Abraham Kallivayalil, Andi Jaylangkara Tanra, Kok Yoon Chee, Yu-Tao Xiang, Kang Sim, Afzal Javed, Chay Hoon Tan, Norman Sartorius, Shigenobu Kanba, Naotaka Shinfuku, Yong Chon Park, Seon-Cheol Park
Journal of Personalized Medicine, 12, 1, 33, 33, MDPI AG, 03 Jan. 2022, [Peer-reviewed]
English, Scientific journal, The symptom heterogeneity of schizophrenia is consistent with Wittgenstein’s analogy of a language game. From the perspective of precision medicine, this study aimed to estimate the symptom presentation and identify the psychonectome in Asian patients, using data obtained from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics. We constructed a network structure of the Brief Psychiatric Rating Scale (BPRS) items in 1438 Asian patients with schizophrenia. Furthermore, all the BPRS items were considered to be an ordered categorical variable ranging in value from 1–7. Motor retardation was situated most centrally within the BPRS network structure, followed by depressive mood and unusual thought content. Contrastingly, hallucinatory behavior was situated least centrally within the network structure. Using a community detection algorithm, the BPRS items were organized into positive, negative, and general symptom clusters. Overall, DSM symptoms were not more central than non-DSM symptoms within the symptom network of Asian patients with schizophrenia. Thus, motor retardation, which results from the unmet needs associated with current antipsychotic medications for schizophrenia, may be a tailored treatment target for Asian patients with schizophrenia. Based on these findings, targeting non-dopamine systems (glutamate, γ-aminobutyric acid) may represent an effective strategy with respect to precision medicine for psychosis.

Optimized protocol for the extraction of RNA and DNA from frozen whole blood sample stored in a single EDTA tube
Hirotaka Yamagata, Ayumi Kobayashi, Ryouichi Tsunedomi, Tomoe Seki, Masaaki Kobayashi, Kosuke Hagiwara, Chong Chen, Shusaku Uchida, Go Okada, Manabu Fuchikami, Toshiharu Kamishikiryo, Jun-ichi Iga, Shusuke Numata, Makoto Kinoshita, Takahiro A. Kato, Ryota Hashimoto, Hiroaki Nagano, Yasumasa Okamoto, Shuichi Ueno, Tetsuro Ohmori, Shin Nakagawa
Scientific Reports, 11, 1, 17075, 17075, Springer Science and Business Media LLC, Dec. 2021, [Peer-reviewed]
Scientific journal, Cryopreservation of whole blood is useful for DNA collection, and clinical and basic research. Blood samples in ethylenediaminetetraacetic acid disodium salt (EDTA) tubes stored at − 80 °C are suitable for DNA extraction, but not for high-quality RNA extraction. Herein, a new methodology for high-quality RNA extraction from human blood samples is described. Quickly thawing frozen whole blood on aluminum blocks at room temperature could minimize RNA degradation, and improve RNA yield and quality compared with thawing the samples in a 37 °C water bath. Furthermore, the use of the NucleoSpin RNA kit increased RNA yield by fivefold compared with the PAXgene Blood RNA Kit. Thawing blood samples on aluminum blocks significantly increased the DNA yield by ~ 20% compared with thawing in a 37 °C water bath or on ice. Moreover, by thawing on aluminum blocks and using the NucleoSpin RNA and QIAamp DNA Blood kits, the extraction of RNA and DNA of sufficient quality and quantity was achieved from frozen EDTA whole blood samples that were stored for up to 8.5 years. Thus, extracting RNA from frozen whole blood in EDTA tubes after long-term storage is feasible. These findings may help advance gene expression analysis, as well as biomarker research for various diseases.

養護教諭を対象としたオンサイト・オンラインによる自殺予防ゲートキーパー研修の効果比較-予備的検討　　　　　　　　　　　　　　　
浦田 裕美, 小原 圭司, 久保 浩明, 加藤隆弘
ストレス科学, 36, 1, 54, 62, Sep. 2021
Japanese, Scientific journal

Association between Self-Restraint Behavior, Stigma and Depressive Tendency in Office Workers during the COVID-19 Pandemic in Japan—Self-Restraint Behavior and Depression during the COVID-19
Ryoko Katsuki, Hiroaki Kubo, Itsuki Yamakawa, Naotaka Shinfuku, Norman Sartorius, Shinji Sakamoto, Takahiro A. Kato
Psychiatry International, 2, 3, 300, 309, MDPI AG, 03 Aug. 2021, [Peer-reviewed]
Scientific journal, Background: The COVID-19 pandemic has forced people to change their lifestyles, especially with respect to restrictions on going out. Forced quarantine (i.e., lockdown) and self-restraint behavior (SRB), including self-quarantine, are suggested to induce potential negative impacts on public mental health. SRB seems to be related to governmental policies, each individual’s social background and mental condition; however, no empirical studies have been conducted. Methods: 1053 participants (mainly office workers) from epidemic areas and non-epidemic areas in Japan voluntarily conducted an online survey in June 2020. We assessed COVID-19-related aspects such as the degree of SRB, motivation for SRB, stigma, anxiety and depressive feelings due to COVID-19 by original questionnaires) and general mental health status (social anxiety by MINI-SPIN, depressive tendency by PHQ-9, depression-related personality traits by TACS-22 and resilience by TRS). Results: Regional comparison showed significant differences in SRB and social anxiety. People in epidemic areas tend to refrain from going out. Conversely, people in non-epidemic areas tend to shun the public eye. Regardless of epidemic status, proactive SRB was associated with higher motivation for SRB, higher social anxiety, higher depressive tendency, stronger COVID-19-related psychological factors and lower resilience. Moreover, people with proactive SRB in non-epidemic areas had the highest depressive tendency. Discussion: The present cross-sectional survey among office workers in Japan showed that people with proactive SRB have stronger COVID-19-related anxiety and depressive feelings, regardless of where they live. Our key finding is that people with proactive SRB in non-epidemic areas have the highest depressive tendency. Based on the present finding, we herein propose the following hypothesis: Higher levels of depressive tendency may enhance proactive SRB, which may be partly associated with higher levels of stigma, anxiety and depressive feelings related to COVID-19. Limitations: The general tendencies to avoid danger and stigma were not evaluated. Conclusions: Depressive tendency is suggested to be associated with proactive SRB against COVID-19. Intervention for depressive tendency in non-clinical settings (e.g., workplaces) may help citizens understand the infectious situation appropriately and to behave effectively during the pandemic. Further investigations should be conducted to clarify the present findings.

Psychodynamic group psychotherapy for hikikomori: The case of a socially withdrawn male with schizoaffective disorder
Hiroaki Kubo, Nobuo Aida, Takahiro A. Kato
Journal of Clinical Psychology, 77, 8, 1851, 1864, Wiley, 14 Jul. 2021, [Peer-reviewed]
Scientific journal

Clarifying the Pathophysiological Mechanisms of Neuronal Abnormalities of NF1 by Induced-Neuronal (iN) Cells from Human Fibroblasts
Noriaki Sagata, Yasunari Sakai, Takahiro A. Kato
Neurofibromatosis [Working Title], IntechOpen, 05 Jul. 2021, [Peer-reviewed]
In book, Direct conversion techniques, which generate induced-neuronal (iN) cells from human fibroblasts in less than two weeks, are expected to discover unknown neuronal phenotypes of neuropsychiatric disorders. Here, we present unique gene expression and cell morphology profiles in iN cells derived from neurofibromatosis type 1 (NF1) patients. NF1 is a single-gene multifaceted disorder with relatively high co-occurrence of autism spectrum disorder (ASD). Adenylyl cyclase (AC) dysfunction is one of the candidate pathways in abnormal neuronal development in the brains of NF1 patients. In our study, microarray-based transcriptomic analysis of iN cells from healthy controls (males) and NF1 patients (males) revealed significantly different gene expression of 149 (110 were upregulated and 39 were downregulated). In iN cells derived from NF1 patients (NF1-iN cells), there was a change in the expression level of 90 genes with the addition of forskolin, an AC activator. Furthermore, treatment with forskolin dramatically changed the cell morphology, especially that of NF1-iN cells, from flat-form to spherical-form. Current pilot data indicate the potential therapeutic effect of forskolin or AC activators on neuronal growth in NF1 patients. Further translational research is needed to validate the pilot findings for future drug development of ASD.

Impaired neurite development and mitochondrial dysfunction associated with calcium accumulation in dopaminergic neurons differentiated from the dental pulp stem cells of a patient with metatropic dysplasia
Xiao Sun, Hiroki Kato, Hiroshi Sato, Michiko Torio, Xu Han, Yu Zhang, Yuta Hirofuji, Takahiro A. Kato, Yasunari Sakai, Shouichi Ohga, Satoshi Fukumoto, Keiji Masuda
Biochemistry and Biophysics Reports, 26, 100968, 100968, Elsevier BV, Jul. 2021, [Peer-reviewed]
Scientific journal

CD206 Expression in Induced Microglia-Like Cells From Peripheral Blood as a Surrogate Biomarker for the Specific Immune Microenvironment of Neurosurgical Diseases Including Glioma
Shunya Tanaka, Masahiro Ohgidani, Nobuhiro Hata, Shogo Inamine, Noriaki Sagata, Noritoshi Shirouzu, Nobutaka Mukae, Satoshi O. Suzuki, Hideomi Hamasaki, Ryusuke Hatae, Yuhei Sangatsuda, Yutaka Fujioka, Kosuke Takigawa, Yusuke Funakoshi, Toru Iwaki, Masako Hosoi, Koji Iihara, Masahiro Mizoguchi, Takahiro A. Kato
Frontiers in Immunology, 12, Frontiers Media SA, 29 Jun. 2021, [Peer-reviewed]
Scientific journal, Targeting the unique glioma immune microenvironment is a promising approach in developing breakthrough immunotherapy treatments. However, recent advances in immunotherapy, including the development of immune checkpoint inhibitors, have not improved the outcomes of patients with glioma. A way of monitoring biological activity of immune cells in neural tissues affected by glioma should be developed to address this lack of sensitivity to immunotherapy. Thus, in this study, we sought to examine the feasibility of non-invasive monitoring of glioma-associated microglia/macrophages (GAM) by utilizing our previously developed induced microglia-like (iMG) cells. Primary microglia (pMG) were isolated from surgically obtained brain tissues of 22 patients with neurological diseases. iMG cells were produced from monocytes extracted from the patients’ peripheral blood. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) revealed a significant correlation of the expression levels of representative markers for M1 and M2 microglia phenotypes between pMG and the corresponding iMG cells in each patient (Spearman’s correlation coefficient = 0.5225, P &lt;0.0001). Synchronous upregulation of CD206 expression levels was observed in most patients with glioma (6/9, 66.7%) and almost all patients with glioblastoma (4/5, 80%). Therefore, iMG cells can be used as a minimally invasive tool for monitoring the disease-related immunological state of GAM in various brain diseases, including glioma. CD206 upregulation detected in iMG cells can be used as a surrogate biomarker of glioma.

Development of a 3‐Day Intervention Program for Family Members of Hikikomori Sufferers
Hiroaki Kubo, Hiromi Urata, Motohiro Sakai, Shunsuke Nonaka, Junji Kishimoto, Kazuhiko Saito, Masaru Tateno, Keiji Kobara, Daisuke Fujisawa, Naoki Hashimoto, Yuriko Suzuki, Yoko Honda, Kotaro Otsuka, Shigenobu Kanba, Toshihide Kuroki, Takahiro A. Kato
Japanese Psychological Research, 65, 2, 190, 199, Wiley, 02 Jun. 2021, [Peer-reviewed]
Scientific journal

Metalloproteinase 1 downregulation in neurofibromatosis 1: Therapeutic potential of antimalarial hydroxychloroquine and chloroquine
Gaku Tsuji, Ayako Takai-Yumine, Takahiro Kato, Masutaka Furue
Cell Death & Disease, 12, 6, Springer Science and Business Media LLC, Jun. 2021, [Peer-reviewed]
Scientific journal, Neurofibromatosis type 1 is an autosomal dominant genetic disorder caused by mutation in the neurofibromin 1 (NF1) gene. Its hallmarks are cutaneous findings including neurofibromas, benign peripheral nerve sheath tumors. We analyzed the collagen and matrix metalloproteinase 1 (MMP1) expression in Neurofibromatosis 1 cutaneous neurofibroma and found excessive expression of collagen and reduced expression of MMP1. To identify new therapeutic drugs for neurofibroma, we analyzed phosphorylation of components of the Ras pathway, which underlies NF1 regulation, and applied treatments to block this pathway (PD184352, U0126, and rapamycin) and lysosomal processes (chloroquine (CQ), hydroxychloroquine (HCQ), and bafilomycin A (BafA)) in cultured Neurofibromatosis 1 fibroblasts. We found that downregulation of the MMP1 protein was a key abnormal feature in the neurofibromatosis 1 fibroblasts and that the decreased MMP1 was restored by the lysosomal blockers CQ and HCQ, but not by the blockers of the Ras pathway. Moreover, the MMP1-upregulating activity of those lysosomal blockers was dependent on aryl hydrocarbon receptor (AHR) activation and ERK phosphorylation. Our findings suggest that lysosomal blockers are potential candidates for the treatment of Neurofibromatosis 1 neurofibroma.

The changes in kynurenine metabolites induced by rTMS in treatment-resistant depression: A pilot study
Hiroshi Tateishi, Daiki Setoyama, Dongchon Kang, Jun Matsushima, Ryohei Kojima, Yuka Fujii, Seiji Mawatari, Jun Kikuchi, Yuta Sakemura, Junko Fukuchi, Takumi Shiraishi, Toshihiko Maekawa, Takahiro A. Kato, Toyoko Asami, Yoshito Mizoguchi, Akira Monji
Journal of Psychiatric Research, 138, 194, 199, Elsevier BV, Jun. 2021, [Peer-reviewed]
Scientific journal

Future perspectives of robot psychiatry: can communication robots assist psychiatric evaluation in the COVID-19 pandemic era?
Yuichiro Yoshikawa, Hirokazu Kumazaki, Takahiro A. Kato
Current Opinion in Psychiatry, 34, 3, 277, 286, Ovid Technologies (Wolters Kluwer Health), May 2021, [Peer-reviewed]
Scientific journal

Effectiveness of suicide prevention gatekeeper training for university teachers in Japan
Naoki Hashimoto, Hiroko Takeda, Yutaka Fujii, Yuriko Suzuki, Takahiro A. Kato, Daisuke Fujisawa, Kumi Aoyama-Uehara, Kotaro Otsuka, Nobuyuki Mitsui, Satoshi Asakura, Ichiro Kusumi
Asian Journal of Psychiatry, 102661, 102661, Elsevier BV, Apr. 2021, [Peer-reviewed]
Scientific journal

ProBDNF induces sustained elevation of intracellular Ca 2+ possibly mediated by TRPM7 channels in rodent microglial cells
Yoshito Mizoguchi, Masahiro Ohgidani, Yoshinori Haraguchi, Toru Murakawa‐Hirachi, Takahiro A. Kato, Akira Monji
Glia, Wiley, 19 Mar. 2021, [Peer-reviewed]
Scientific journal

Hyperbaric Oxygen Therapy for Carbon Monoxide-Induced Delayed Neuropsychiatric Sequelae: Case Report of Two Cases and Relevant Literature Review
Akira Monji, Hiroshi Tateishi, Toru Murakawa, Jun Matsushima, Yutaka Kunitake, Takumi Shiraishi, Ryohei Kojima, Takayoshi Inaba, Takahiro Kato, Yoshito Mizoguchi
Case Reports in Psychiatry, 2021, 1, 4, Hindawi Limited, 02 Mar. 2021, [Peer-reviewed]
Scientific journal, We herein report two cases with carbon monoxide- (CO-) induced delayed neuropsychiatric sequelae (DNS) successfully treated with hyperbaric oxygen therapy (HBOT) in attempt suicide by charcoal burning. The two patients with CO-induced DNS were successfully treated with a total of more than 100 sessions of HBOT. Frontal assessment battery (FAB) was useful to examine the effectiveness of HBOT objectively. In the future study, a large-randomized trial is required to establish the efficacy of HBOT for the treatment of DNS.

Use of a tele-operated robot to increase sociability in individuals with autism spectrum disorder who display Hikikomori
Hirokazu Kumazaki, Taro Muramatsu, Yuichiro Yoshikawa, Takahiro A. Kato, Hiroshi Ishiguro, Mitsuru Kikuchi, Masaru Mimura
Asian Journal of Psychiatry, 57, 102588, 102588, Elsevier BV, Mar. 2021, [Peer-reviewed]
Scientific journal

Plasma acetylcholine and nicotinic acid are correlated with focused preference for photographed females in depressed males: an economic game study
Hiroaki Kubo, Daiki Setoyama, Motoki Watabe, Masahiro Ohgidani, Kohei Hayakawa, Nobuki Kuwano, Mina Sato-Kasai, Ryoko Katsuki, Shigenobu Kanba, Dongchon Kang, Takahiro A. Kato
Scientific Reports, 11, 1, 2199, 2199, Springer Science and Business Media LLC, Jan. 2021, [Peer-reviewed]
Scientific journal, Interpersonal difficulties are often observed in major depressive disorder (MDD), while the underlying psychological and biological mechanisms have not yet been elucidated. In the present case–control study, a PC-based trust game was conducted for 38 drug-free MDD patients and 38 healthy controls (HC). In the trust game, participants invested money in a partner (trusting behaviors), and also rated each partner’s attractiveness (preference for others). In addition, blood biomarkers including metabolites were measured. Both MDD and HC males exhibited more trusting behaviors compared to females. MDD males’ preference for ordinary-attractive partners (lay-person photographs) was lower than HC males, whereas their preference for high-attractive females (fashion-model photographs) was similar levels to HC males. This tendency in MDD males could reflect a “focused (narrowed) preference for females”. As for blood biomarker analysis, the levels of 37 metabolites including acetylcholine, AMP, GMP, nicotinic acid and tryptophan were significantly different between two groups. Interestingly, among male participants, acetylcholine and nicotinic acid were negatively correlated with the level of focused preference for photographed females. In sum, we have revealed some behavioral, psychological and biological traits of trusting behaviors and preference for others especially in MDD males. Larger studies should be conducted to validate our preliminary findings.

Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model
Takehiko Yamanashi, Masaaki Iwata, Midori Shibushita, Kyohei Tsunetomi, Mayu Nagata, Naofumi Kajitani, Akihiko Miura, Ryoichi Matsuo, Tsuyoshi Nishiguchi, Takahiro A. Kato, Daiki Setoyama, Yukihiko Shirayama, Ken Watanabe, Gen Shinozaki, Koichi Kaneko
Scientific Reports, 10, 1, 21629, 21629, Springer Science and Business Media LLC, Dec. 2020, [Peer-reviewed]
Scientific journal, Accumulating evidence suggests that elevated inflammation contributes to the pathophysiology of post-traumatic stress disorder (PTSD) and that anti-inflammatory drugs might be a new treatment strategy for PTSD. It has been reported that beta-hydroxybutyrate (BHB), one of the main ketone bodies produced, can have an anti-inflammatory and antidepressant effect. Here, we investigated the potential anti-anxiety and anti-inflammatory effects of BHB using a rodent PTSD model, induced by single prolonged stress (SPS). Male, Sprague–Dawley rats were employed in this study. Repeated administration of BHB attenuated SPS-induced anxiety-related behaviors evaluated by the elevated plus maze test. SPS increased the serum levels of TNF-α and IL-1β. In contrast, BHB administration partially attenuated the increase of serum TNF-α. These findings demonstrate that BHB exerts its anxiolytic effects, possibly by inhibiting systemic TNF-α. Hence, BHB may be a novel therapeutic candidate for the treatment of PTSD.

Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis
Hisayuki Erabi, Go Okada, Chiyo Shibasaki, Daiki Setoyama, Dongchon Kang, Masahiro Takamura, Atsuo Yoshino, Manabu Fuchikami, Akiko Kurata, Takahiro A. Kato, Shigeto Yamawaki, Yasumasa Okamoto
Scientific Reports, 10, 1, Springer Science and Business Media LLC, Dec. 2020, [Peer-reviewed]
Scientific journal,
Since optimal treatment at an early stage leads to remission of symptoms and recovery of function, putative biomarkers leading to early diagnosis and prediction of therapeutic responses are desired. The current study aimed to use a metabolomic approach to extract metabolites involved in both the diagnosis of major depressive disorder (MDD) and the prediction of therapeutic response for escitalopram. We compared plasma metabolites of MDD patients (n = 88) with those in healthy participants (n = 88) and found significant differences in the concentrations of 20 metabolites. We measured the Hamilton Rating Scale for Depression (HRSD) on 62 patients who completed approximately six-week treatment with escitalopram before and after treatment and found that kynurenic acid and kynurenine were significantly and negatively associated with HRSD reduction. Only one metabolite, kynurenic acid, was detected among 73 metabolites for overlapped biomarkers. Kynurenic acid was lower in MDD, and lower levels showed a better therapeutic response to escitalopram. Kynurenic acid is a metabolite in the kynurenine pathway that has been widely accepted as being a major mechanism in MDD. Overlapping biomarkers that facilitate diagnosis and prediction of the treatment response may help to improve disease classification and reduce the exposure of patients to less effective treatments in MDD.

GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons
Satoshi Akamine, Sayaka Okuzono, Hiroyuki Yamamoto, Daiki Setoyama, Noriaki Sagata, Masahiro Ohgidani, Takahiro A. Kato, Tohru Ishitani, Hiroki Kato, Keiji Masuda, Yuki Matsushita, Hiroaki Ono, Yoshito Ishizaki, Masafumi Sanefuji, Hirotomo Saitsu, Naomichi Matsumoto, Dongchon Kang, Shigenobu Kanba, Yusaku Nakabeppu, Yasunari Sakai, Shouichi Ohga
The FASEB Journal, Wiley, 27 Oct. 2020, [Peer-reviewed]
Scientific journal

Autism spectrum conditions in hikikomori : A pilot case–control study
Ryoko Katsuki, Masaru Tateno, Hiroaki Kubo, Keita Kurahara, Kohei Hayakawa, Nobuki Kuwano, Shigenobu Kanba, Takahiro A. Kato
Psychiatry and Clinical Neurosciences, Wiley, 13 Oct. 2020, [Peer-reviewed]
Scientific journal

Forskolin rapidly enhances neuron‐like morphological change of directly induced‐neuronal cells from neurofibromatosis type 1 patients
Noriaki Sagata, Shin‐ichi Kano, Masahiro Ohgidani, Shogo Inamine, Yasunari Sakai, Hiroki Kato, Keiji Masuda, Takeshi Nakahara, Makiko Nakahara‐Kido, Shouichi Ohga, Masutaka Furue, Akira Sawa, Shigenobu Kanba, Takahiro A. Kato
Neuropsychopharmacology Reports, Wiley, 10 Oct. 2020, [Peer-reviewed]
Scientific journal

Forced social isolation due to COVID-19 and consequent mental health problems: lessons from hikikomori
Kato TA, Sartorius N, Shinfuku N
Psychiatry and Clinical Neurosciences, 74, 9, 506, 507, Sep. 2020, [Peer-reviewed], [International Magazine]
English

Personality classification enhances blood metabolome analysis and biotyping for major depressive disorders: two-species investigation
Setoyama D, Yoshino A, Takamura M, Okada G, Iwata M, Tsunetomi K, Ohgidani M, Kuwano N, Yoshimoto J, Okamoto Y, Yamawaki S, Kanba S, Kang D, Kato TA
Journal of Affective Disorders, 279, 2021, 20, 30, Sep. 2020, [Peer-reviewed], [International Magazine]
English

Social withdrawal in major depressive disorder a case-control study of hikikomori in japan
Alan R. Teo, Sarah Nelson, Wynn Strange, Hiroaki Kubo, Ryoko Katsuki, Keita Kurahara, Shigenobu Kanba, Takahiro A. Kato
Journal of Affective Disorders, 274, 1142, 1146, Sep. 2020, [Peer-reviewed]
English, Background: Social withdrawal is a feature of a number of psychiatric disorders including major depressive disorder (MDD), yet research examining social withdrawal as a feature of MDD is rare. Methods: This was a retrospective case-control study. Participants (N = 67) were recruited through an outpatient clinic at an academic medical center in Japan. Major depressive disorder (MDD) and social withdrawal were established with the Structured Clinical Interview for DSM-IV Axis I Disorders and a semi-structured psychiatric interview, respectively. Participants also completed self-report measures. Results: We classified 24 participants as cases (MDD with social withdrawal) and 43 participants as controls (MDD without social withdrawal). Cases, on average, were more likely to have lower education level, prior episodes of depression, and higher suicidal ideation at baseline than controls. In unadjusted regression models, cases had significantly less social connection, less reward dependence, less self-directedness, and higher scores on scales of modern-type depression and hikikomori. In adjusted regression models, associations between social withdrawal and hikikomori (p<0.01) and reward dependence (p = 0.03) remained significant. Limitations: The sample was limited in size and drawn from a single site. Conclusions: In patients with MDD, social withdrawal may have subtle associations with clinical symptoms, social connection, and personality traits. Developing a better understanding of social withdrawal's phenotype in depression requires more in-depth examination.

Coprescription of mood stabilizers in schizophrenia, dosing, and clinical correlates: An international study
Lim W K, Chew Q H, He YL, Si TM, Chiu FK H, Xiang Y T, Kato TA, Kanba S, Shinfuku N, Lee M S, Park SC, Park YC, Chong MY, Lin SK, u Yang SY, Tripathi A, Avasthi A, Grover S, Kallivayalil RA, Udomratn P, Chee KY, Tanra AJ, Rabbani MG, Javed A, Kathiarachchi S, Waas D, Myint WA, Sartorius N, Tran VC, Nguyen KV, Tan CH, Baldessarini RJ, Sim K*
Human Psychopharmacology Clinical and Experimental, e2752, e2752, Aug. 2020, [Peer-reviewed], [International Magazine]
English

Relationship Between Body Mass Index and Extrapyramidal Symptoms in Asian Patients with Schizophrenia: The Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP)
Seon-Cheol Park, Adarsh Tripathi, Ajit Avasthi, Sandeep Grover, Andi J. Tanra, Takahiro A. Kato, Toshiya Inada, Kok Yoon Chee, Mian-Yoon Chong, Shu-Yu Yang, Sih-Ku Lin, Kang Sim, Yu-Tao Xiang, Afzal Javed, Norman Sartorius, Naotaka Shinfuku, Yong Chon Park
Psychiatria Danubina, 32, 2, 176, 186, Aug. 2020, [Peer-reviewed], [International Magazine]
English

Changes in interleukin-1 beta induced by rTMS are significantly correlated with partial improvement of cognitive dysfunction in treatment-resistant depression a pilot study
Hiroshi Tateishi, Yoshito Mizoguchi, Atsushi Kawaguchi, Yoshiomi Imamura, Jun Matsushima, Hiroko Kunitake, Toru Murakawa, Yoshinori Haraguchi, Yutaka Kunitake, Toshihiko Maekawa, Takahiro A. Kato, Toyoko Asami, Akira Monji
Psychiatry research, 289, Jul. 2020, [Peer-reviewed]
English, The impairment experienced by many individuals with depression is closely related to the cognitive symptoms of the disorder. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation method that provides a promising technique for improving cognitive symptoms in treatment-resistant depression (TRD). It has recently been demonstrated that TRD is associated with increased inflammatory process. In the present study, we investigated whether a relationship exists between changes in cognitive function and those in inflammatory cytokines before and after rTMS treatment. Eleven patients with TRD were enrolled in a high-frequency (10 Hz) rTMS study. Cognitive function, depressive symptoms and serum concentration of inflammatory cytokines (interleukin (IL)-1β, IL-6 and tumor necrosis factor-α) were measured at baseline and at the endpoint of rTMS treatment. rTMS treatment significantly improved depressive symptom scores and some subscales of cognitive dysfunction. The present study has demonstrated that partial changes in cognitive function and changes in IL-1β were significantly correlated. The partial improvement of cognitive dysfunction by rTMS in the present study might be attributable to the reduction of peripheral IL-1β levels. The present results should be replicated for verification in future studies.

Dyskinesia is most centrally situated in an estimated network of extrapyramidal syndrome in Asian patients with schizophrenia findings from research on Asian psychotropic prescription patterns for antipsychotics
Seon Cheol Park, Gyung Mee Kim, Takahiro A. Kato, Mian Yoon Chong, Shih Ku Lin, Shu Yu Yang, Ajit Avasthi, Sandeep Grover, Roy Abraham Kallivayalil, Yu Tao Xiang, Kok Yoon Chee, Andi Jayalangkara Tanra, Chay Hoon Tan, Kang Sim, Norman Sartorius, Naotaka Shinfuku, Yong Chon Park, Toshiya Inada
Nordic Journal of Psychiatry, Jun. 2020, [Peer-reviewed]
English, Background: Network analysis provides a new viewpoint that explicates intertwined and interrelated symptoms into dynamic causal architectures of symptom clusters. This is a process called ‘symptomics’ and is concurrently applied to various areas of symptomatology. Aims: Using the data from Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP), we aimed to estimate a network model of extrapyramidal syndrome in patients with schizophrenia. Methods: Using data from REAP-AP, extrapyramidal symptoms of 1046 Asian patients with schizophrenia were evaluated using the nine items of the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS). The estimated network of the ordered-categorical DIEPSS items consisted of nodes (symptoms) and edges (interconnections). A community detection algorithm was also used to identify distinctive symptom clusters, and correlation stability coefficients were used to evaluate the centrality stability. Results: An interpretable level of node strength centrality was ensured with a correlation coefficient. An estimated network of extrapyramidal syndrome showed that 26 (72.2%) of all possible 35 edges were estimated to be greater than zero. Dyskinesia was most centrally situated within the estimated network. In addition, earlier antipsychotic-induced extrapyramidal symptoms were divided into three distinctive clusters–extrapyramidal syndrome without parkinsonism, postural instability and gait difficulty-dominant parkinsonism, and tremor-dominant parkinsonism. Conclusions: Our findings showed that dyskinesia is the most central domain in an estimated network structure of extrapyramidal syndrome in Asian patients with schizophrenia. These findings are consistent with the speculation that acute dystonia, akathisia, and parkinsonism could be the risk factors of tardive dyskinesia.

Patterns of Long Acting Injectable Antipsychotic Use and Associated Clinical Factors in Schizophrenia Amongst 15 Asian Countries and Region
Chao Tian Tang, Ee Cheong Chua, Qian Hui Chew, Yan‐Ling He, Tian‐Mei Si, Helen F.‐K. Chiu, Yu‐Tao Xiang, Takahiro A. Kato, Shigenobu Kanba, Naotaka Shinfuku, Min‐Soo Lee, Seon‐Cheol Park, Yong‐Chon Park, Mian‐Yoon Chong, Shih‐Ku Lin, Shu‐Yu Yang, Adarsh Tripathi, Ajit Avasthi, Sandeep Grover, Roy A. Kallivayalil, Pichet Udomratn, Kok Yoon Chee, Andi J. Tanra, Md Golam Rabbani, Afzal Javed, Samudra Kathiarachchi, Dulshika Waas, Wing Aung Myint, Norman Sartorius, Van Cuong Tran, Kim Viet Nguyen, Chay‐Hoon Tan, Ross J. Baldessarini, Kang Sim
Asia-Pacific Psychiatry, e12393, May 2020, [Peer-reviewed], [International Magazine]
English

International experience of Hikikomori (prolonged social withdrawal), and its relevance to psychiatric research
Tan MPJ*, Lee WE, Kato TA
BJPsych International, 1, 3, May 2020, [Peer-reviewed], [International Magazine]
English

Internet society, internet addiction, and pathological social withdrawal: the chicken and egg dilemma for internet addiction and hikikomori.
Takahiro A Kato, Naotaka Shinfuku, Masaru Tateno
Current opinion in psychiatry, 33, 3, 264, 270, May 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE OF REVIEW: Internet society has made our daily life more convenient, while its negative consequences especially internet, smartphone, and gaming addiction are emerging. At the same time, the phenomenon of pathological social withdrawal called 'hikikomori' has been increasingly highlighted as a problematic behavior in Japan. Now hikikomori is becoming a global mental health issue. The interaction between internet society, internet addiction, and hikikomori has not been well clarified. RECENT FINDINGS: A case vignette survey among psychiatrists suggested that hikikomori cases could be comorbid with internet addiction. In reality, hikikomori cases with internet addiction have been reported internationally. A recent survey among college/university students in Japan has indicated positive interactions between internet addiction, smartphone addiction, gaming internet disorder, and hikikomori-tendencies. SUMMARY: The cause of hikikomori has not been well understood, and the emergence of internet may be one of the important contributing factors for the occurrence of hikikomori. Whether pathological social withdrawal creates internet addiction, or internet overuse creates hikikomori remains unclear. Both possibilities exist, and we herein propose the conceptual model of these hypothetical interactions. Clarifying the mechanisms of both conditions will help to solve these crucial issues for contemporary urban societies.

Network analysis of the depressive symptom profiles in Asian patients with depressive disorders: Findings from the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD).
Seon-Cheol Park, Eun Young Jang, Yu-Tao Xiang, Shigenobu Kanba, Takahiro A Kato, Mian-Yoon Chong, Shih-Ku Lin, Shu-Yu Yang, Ajit Avasthi, Sandeep Grover, Roy A Kallivayalil, Pichet Udomratn, Kok Yoon Chee, Andi J Tanra, Chay-Hoon Tan, Kang Sim, Norman Sartorius, Yong Chon Park, Naotaka Shinfuku
Psychiatry and clinical neurosciences, 12 Feb. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, AIM: We aimed to estimate the network structures of depressive symptoms using network analysis and evaluated the geographic regional differences in theses network structures among Asian patients with depressive disorders. METHODS: Using data from the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD), the network of the ICD-10 diagnostic criteria for depressive episode was estimated from 1174 Asian patients with depressive disorders. The node strength centrality of all ICD-10 diagnostic criteria for a depressive episode was estimated using a community-detection algorithm. In addition, networks of depressive symptoms were estimated separately among East Asian patients and South or Southeast Asian patients. Moreover, networks were estimated separately among Asian patients from high-income countries and those from middle-income countries. RESULTS: Persistent sadness, fatigue, and loss of interest were the most centrally situated within the network of depressive symptoms in Asian patients with depressive disorders overall. A community-detection algorithm estimated that when excluding psychomotor disturbance as an outlier, the other nine symptoms formed the largest clinically meaningful cluster. Geographic and economic variations in networks of depressive symptoms were evaluated. CONCLUSION: Our findings demonstrated that the typical symptoms of the ICD-10 diagnostic criteria for depressive episode are the most centrally situated within the network of depressive symptoms. Furthermore, our findings suggested that cultural influences related to geographic and economic distributions of participants could influence the estimated depressive symptom network in Asian patients with depressive disorders.

Defining pathological social withdrawal proposed diagnostic criteria for hikikomori
Takahiro A. Kato, Shigenobu Kanba, Alan R. Teo
World Psychiatry, 19, 1, 116, 117, Feb. 2020, [Peer-reviewed]
English

Involvement of exchange protein directly activated by cAMP and tumor progression locus 2 in IL-1β production in microglial cells following activation of β-adrenergic receptors
Hidetoshi Tozaki-Saitoh, Izumi Sasaki, Tomohiro Yamashita, Masako Hosoi, Takahiro A. Kato, Makoto Tsuda
Journal of Pharmacological Sciences, Jan. 2020, [Peer-reviewed]
English, Endogenous noradrenaline (NA) has multiple bioactive functions and, in the central nervous system (CNS), has been implicated in modulating neuroinflammation via β-adrenergic receptors (β-ARs). Microglia, resident macrophages in the CNS, have a central role in the brain immune system and have been reported to be activated by NA. However, intracellular signaling mechanisms of the AR-mediated proinflammatory responses of microglia are not fully understood. Using a rapid and stable in vitro reporter assay system to evaluate IL-1β production in microglial BV2 cells, we found that NA and the β-AR agonist isoproterenol upregulated the IL-1β reporter activity. This effect was suppressed by β-AR antagonists. We further examined the involvement of EPAC (exchange protein directly activated by cAMP) and TPL2 (tumor progression locus 2, MAP3K8) and found that inhibitors for EPAC and TPL2 reduced AR agonist-induced IL-1β reporter activity. These inhibitors also suppressed NA-induced endogenous Il1b mRNA expression and IL-1β protein production. Our results suggest that EPAC and TPL2 are involved in β-AR-mediated IL-1β production in microglial cells, and extend our understanding of its intracellular signaling mechanism.

Development of 5-day hikikomori intervention program for family members: A single-arm pilot trial.
Hiroaki Kubo, Hiromi Urata, Motohiro Sakai, Shunsuke Nonaka, Kazuhiko Saito, Masaru Tateno, Keiji Kobara, Naoki Hashimoto, Daisuke Fujisawa, Yuriko Suzuki, Kotaro Otsuka, Hiroho Kamimae, Yuya Muto, Takashi Usami, Yoko Honda, Junji Kishimoto, Toshihide Kuroki, Shigenobu Kanba, Takahiro A Kato
Heliyon, 6, 1, e03011, Jan. 2020, [Peer-reviewed], [International Magazine]
English, Backgrounds: Hikikomori, a severe form of social withdrawal, is increasingly a serious mental health issue worldwide. Hikikomori is comorbid with various psychiatric conditions including depression, social anxiety and suicidal behaviors. Family support is encouraged as a vital first step, however evidence-based programs have yet to be established. Mental Health First Aid (MHFA) is one of the most well-validated educational programs encouraging lay people such as family members, to support close persons suffering from various psychiatric conditions such as depression, anxiety and suicidal behaviors. Methods: We newly developed an educational program for family members of hikikomori sufferers mainly based on MHFA and 'Community Reinforcement and Family Training (CRAFT)' with role-play and homework. As a single-arm trial, 21 parents (7 fathers and 14 mothers) living with hikikomori sufferers participated in our program with five once-a-week sessions (2 h per session) and six monthly follow-ups, and its effectiveness was evaluated using various self-rated questionnaires. Results: Perceived skills toward a depressed hikikomori case vignette, stigma held by participants, and subscales of two problematic and one adaptive behaviors of hikikomori sufferers were improved throughout the sessions and follow-ups. In addition, positive behavioral changes of hikikomori sufferers such as improved social participation were reported by participants. Limitations: Single-arm design and evaluation using self-rated questionnaires are the main limitations of the present study. Conclusions: Our newly developed program has positive effects on family members in their contact and support of hikikomori sufferers. Future trials with control groups are required to validate the effectiveness of this program.

Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress.
Kanako Nozaki, Hikaru Ito, Masahiro Ohgidani, Yosuke Yamawaki, Ezgi Hatice Sahin, Takashi Kitajima, Seishi Katsumata, Shigeto Yamawaki, Takahiro A Kato, Hidenori Aizawa
Neuropharmacology, 162, 107835, 107835, 01 Jan. 2020, [Peer-reviewed], [International Magazine]
English, In preclinical models, it has been reported that social defeat stress activates microglial cells in the CNS. Translocator protein 18 kDa (TSPO) is a mitochondrial protein expressed on microglia in the CNS that has been proposed to be a useful biomarker for brain injury and inflammation. We hypothesized that a TSPO antagonist, ONO-2952, would inhibit the neuroinflammation induced by microglial hyperactivation and associated depressive-like behaviors. An in vitro analysis showed that ONO-2952 suppressed the release of pro-inflammatory cytokines and mitochondrial reactive oxygen species in cultured microglia stimulated by lipopolysaccharide. In mice submitted to chronic social defeat stress, microglia predominantly expressed TSPO in limbic areas implicated in depressive-like behaviors, including the amygdala, ventral hippocampus and nucleus accumbens, in which an increase in the production of pro-inflammatory cytokines in vivo were associated. Treating animals with ONO-2952 during chronic social defeat stress ameliorated impairments in social avoidance and anxiety-like behaviors and suppressed pro-inflammatory cytokine production, suggesting that ONO-2952 exerted an anti-stress effect in this animal model of depression. Thus, targeting TSPO as a candidate for the development of antidepressants that reduce susceptibility to chronic stress could pave the way toward therapeutic interventions for relapse prophylaxis in depression.

The Self-Construal Scale: A Potential Tool for Predicting Subjective Well-Being of Individuals With Autism Spectrum Disorder.
Kaneko S, Kato TA, Makinodan M, Komori T, Ishida R, Kishimoto N, Takahashi M, Yasuda Y, Hashimoto R, Iwasaka H, Tanaka A, Uchida Y, Kanba S, Kishimoto T
Autism research : official journal of the International Society for Autism Research, Dec. 2019, [Peer-reviewed]

Improvement of frontal lobe dysfunction and white matter integrity by rTMS in treatment-resistant depression
Hiroshi Tateishi, Masashi Nishihara, Atsushi Kawaguchi, Jun Matsushima, Toru Murakawa, Yoshinori Haraguchi, Yutaka Kunitake, Toshihiko Maekawa, Takahiro A. Kato, Toyoko Asami, Yoshito Mizoguchi, Akira Monji
Neuropsychiatric Disease and Treatment, 15, 3079, 3087, Nov. 2019, [Peer-reviewed]
English, Aim: The impairment experienced by many individuals with depression is closely related to the cognitive symptoms of the disorder. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation method providing a promising technique for improving cognitive symptoms in treatment-resistant depression (TRD). In the present study, we investigated whether a relationship exists between improvements in frontal lobe dysfunction induced by rTMS and improvement of white matter integrity revealed by diffusion tensor imaging (DTI) in TRD patients receiving rTMS treatment. Methods: A total of 12 patients with TRD were enrolled in a high-frequency (10 Hz) rTMS study (August 2013-January 2019). Frontal lobe function and depressive symptoms were assessed at baseline and at the endpoint of rTMS treatment. Fractional anisotropy (FA), as a measure of white matter integrity obtained from DTI, was investigated using a region-ofinterest (ROI) approach. Results: rTMS treatment significantly improved depressive symptom scores and some subscales of frontal lobe dysfunction. Category scores in the Word Fluency Test and scores on part 3 of the Color Stroop Test were improved independently of the improvement of depressive symptoms. In the ROI analysis, none of the FA increases in any region were correlated with improvement of any frontal lobe function (n = 12). Conclusion: Although rTMS resulted in partial improvement of frontal lobe dysfunction as well as white matter integrity, we found no correlation between improved frontal lobe dysfunction and improved white matter integrity in TRD patients.

Establishing the cut-off scores for the severity ranges of schizophrenia on the BPRS-6 scale findings from the REAP-AP
Seon Cheol Park, Eun Young Jang, Kiwon Kim, Hoseon Lee, Joonho Choi, Amitava Dan, Arshad Hussain, Andi Jayalangkara Tanra, Takahiro A. Kato, Kok Yoon Chee, Sih Ku Lin, Chay Hoon Tan, Afzal Javed, Norman Sartorius, Naotaka Shinfuku, Yong Chon Park
Psychiatry and Clinical Psychopharmacology, 29, 4, 895, 898, Oct. 2019, [Peer-reviewed]
English, Objective: Using data from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP), our study aimed to establish the remission and severity ranges (mild, moderate, and severe) of schizophrenia on the Brief Psychiatric Rating Scale-6 (BPRS-6). Methods: A total of 1,438 patients with schizophrenia from India, Indonesia, Japan, Malaysia, and Taiwan were enrolled in the study. Using the receiver operating characteristic (ROC) curve analyses, the optimal cut-off scores for the remission and severity ranges on the BPRS-6 were established. Results: The scalability of the BPRS-6 was considered to have an acceptable “unidimensionality” (coefficient of scalability = 0.43). The cut-off scores for the remission of schizophrenia and mild, moderate, and severe schizophrenia can be optimally defined as the BPRS-6 total score of <5, 5–9, 10–19 and >20, respectively. Conclusion: The BPRS-6 can be a promising, brief, and unidimensional rating scale to supplement the measurement-based care of schizophrenia.

In vitro modeling of the bipolar disorder and schizophrenia using patient-derived induced pluripotent stem cells with copy number variations of PCDH15 and RELN
Takaya Ishii, Mitsuru Ishikawa, Koki Fujimori, Takuji Maeda, Itaru Kushima, Yuko Arioka, Daisuke Mori, Yuhki Nakatake, Bun Yamagata, Shintaro Nio, Takahiro A. Kato, Nan Yang, Marius Wernig, Shigenobu Kanba, Masaru Mimura, Norio Ozaki, Hideyuki Okano
eNeuro, 6, 5, Oct. 2019, [Peer-reviewed]
English, (Figure Presented) Bipolar disorder (BP) and schizophrenia (SCZ) are major psychiatric disorders, but the molecular mechanisms underlying the complicated pathologies of these disorders remain unclear. It is difficult to establish adequate in vitro models for pathological analysis because of the heterogeneity of these disorders. In the present study, to recapitulate the pathologies of these disorders in vitro, we established in vitro models by differentiating mature neurons from human induced pluripotent stem cells (hiPSCs) derived from BP and SCZ patient with contributive copy number variations, as follows: two BP patients with PCDH15 deletion and one SCZ patient with RELN deletion. Glutamatergic neurons and GABAergic neurons were induced from hiPSCs under optimized conditions. Both types of induced neurons from both hiPSCs exhibited similar phenotypes of MAP2 (microtubule-associated protein 2)-positive dendrite shortening and decreasing synapse numbers. Additionally, we analyzed isogenic PCDH15-or RELN-deleted cells. The dendrite and synapse phenotypes of isogenic neurons were partially similar to those of patient-derived neurons. These results suggest that the observed phenotypes are general phenotypes of psychiatric disorders, and our in vitro models using hiPSC-based technology may be suitable for analysis of the pathologies of psychiatric disorders.

The Hikikomori' syndrome Worldwide prevalence and co-occurring major psychiatric disorders: A systematic review and meta-analysis protocol
Andrea Pozza, Anna Coluccia, Takahiro Kato, Marco Gaetani, Fabio Ferretti
BMJ open, 9, 9, Sep. 2019, [Peer-reviewed]
English, Introduction The Hikikomori' syndrome (HS) consists of prolonged and severe social withdrawal. It has been studied first in Japan and recently has increasingly drawn the attention of researchers and clinicians all over the world. It is unclear whether it exists in other cultural contexts than Asia. The existing systematic reviews did not provide a quantitative synthesis on its prevalence. In addition, a summary of the co-occurring rates of psychiatric disorders is lacking. To provide a more comprehensive understanding of the clinical picture, it seems important to investigate which psychiatric disorders listed in the classification systems are most frequently associated with this psychological condition affecting young people. This paper describes a systematic review and meta-analysis protocol summarising worldwide prevalence of the HS in general population and clinical samples with psychiatric disorders. The review will also assess the co-occurrence between HS and each psychiatric disorder defined by any version of the Diagnostic and Statistical Manual of Mental Disorders (DSM) or International Classification of Diseases (ICD) in any clinical samples with psychiatric disorders. Methods and analysis A systematic review will be conducted according to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Studies will be included if they use youth aged 12-35 years, recruited from general population or population with psychiatric disorders, if they use international criteria to diagnose HS. No restriction about design or language will be applied. The search will be conducted during the first week of November 2019 by two independent reviewers through the databases Scopus, PubMed, PsycINFO, Web of Science, by examining study references, by looking for conference proceedings/dissertations/theses, by contacting study corresponding authors. Random-effect meta-analysis will be performed by computing effect sizes as logit event rates. Study quality will be assessed through the Newcastle-Ottawa Scale. Ethics and dissemination The current review does not require ethics approval. The results will be disseminated through conference presentations and publications in peer-reviewed journals. PROSPERO registration number CRD 42018098747.

Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia.
Park SC, Oh HS, Tripathi A, Kallivayalil RA, Avasthi A, Grover S, Tanra AJ, Kanba S, Kato TA, Inada T, Chee KY, Chong MY, Lin SK, Sim K, Xiang YT, Tan CH, Javed A, Sartorius N, Shinfuku N, Park YC
Nordic journal of psychiatry, 73, 6, 323, 330, Aug. 2019, [Peer-reviewed]

Cuprizone-treated mice, a possible model of schizophrenia, highlighting the simultaneous abnormalities of GABA, serine and glycine in hippocampus.
Hayakawa E, Ohgidani M, Fujimura Y, Kanba S, Miura D, Kato TA
Schizophrenia research, 210, 326, 328, Aug. 2019, [Peer-reviewed]

Smartphone addiction in Japanese college students: Usefulness of the japanese version of the smartphone addiction scale as a screening tool for a new form of internet addiction
Masaru Tateno, Dai Jin Kim, Alan R. Teo, Norbert Skokauskas, Anthony P.S. Guerrero, Takahiro A. Kato
Psychiatry Investigation, 16, 115, 120, 01 Feb. 2019

Suicide and microglia: Recent findings and future perspectives based on human studies
Hisaomi Suzuki, Masahiro Ohgidani, Nobuki Kuwano, Fabrice Chrétien, Geoffroy Lorin de la Grandmaison, Mitsumoto Onaya, Itaru Tominaga, Daiki Setoyama, Dongchon Kang, Masaru Mimura, Shigenobu Kanba, Takahiro A. Kato
Frontiers in Cellular Neuroscience, 13, 1, 10, 29 Jan. 2019

Hikikomori phenomenon in East Asia Regional perspectives, challenges and opportunities for social health agencies
John C. Wong, Michelle J. Wan, Leoniek M. Kroneman, Takahiro Kato, Wing T. Lo, Paul W. Wong, Chan H. Gloria
Frontiers in Psychiatry, 10, JUN, Jan. 2019, [Peer-reviewed]
English

Clarifying deeper psychological characteristics of hikikomori using the rorschach comprehensive system A pilot case-control study
Ryoko Katsuki, Ayako Inoue, Sílvia Indias, Keita Kurahara, Nobuki Kuwano, Fumika Funatsu, Hiroaki Kubo, Shigenobu Kanba, Takahiro Kato
Frontiers in Psychiatry, 10, JUN, Jan. 2019, [Peer-reviewed]
English, Hikikomori, a form of severe social withdrawal more than 6 months, has increasingly become a crucial issue especially among adolescents. Loneliness, avoidant personality, Japanese culture-related attachment style ("amae"), and difficulty in expressing emotions are suggested to be related to hikikomori. However, deeper psychological aspects have not been well clarified. The Rorschach test is one of the most popular psychological assessment tools to evaluate deeper personality traits. The Rorschach Comprehensive System (CS) has been established as the most reliable scoring method. Until now, no CS research has been conducted focusing on hikikomori. Therefore, we herein conducted a pilot case-control study using CS in clinical cases with and without hikikomori condition. Participants were recruited from the Mood Disorder/Hikikomori Clinic at Kyushu University Hospital. Twenty-Two patients with hikikomori (HK patients) and 18 patients without hikikomori (non-HK patients) participated in the present study. All the 40 participants conducted the self-report Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II) personality questionnaire and CS. Regarding the SCID-II personality questionnaire, various personality traits including passive aggressive trait were significantly higher in HK patients. Among CS variables, HK patients showed higher scores on FC (Form Color) and SumT (total number of texture-related responses). In addition, frequency of SumT was higher in HK patients. The present results suggest that persons with hikikomori are more likely to express emotions indirectly and expect others to presume their feelings and thoughts. Persons with hikikomori may also have difficulty in becoming independent emotionally from primitive dependence and attachment on significant others. Further investigations with larger samples are warranted for validation.

Internet Addiction, Smartphone Addiction, and Hikikomori Trait in Japanese Young Adult: Social Isolation and Social Network.
Masaru Tateno, Alan R Teo, Wataru Ukai, Junichiro Kanazawa, Ryoko Katsuki, Hiroaki Kubo, Takahiro A Kato
Frontiers in psychiatry, 10, 455, 455, 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Background: As the number of internet users increases, problems related to internet overuse are becoming more and more serious. Adolescents and youth may be particularly attracted to and preoccupied with various online activities. In this study, we investigated the relationship of internet addiction, smartphone addiction, and the risk of hikikomori, severe social withdrawal, in Japanese young adult. Methods: The subjects were 478 college/university students in Japan. They were requested to complete the study questionnaire, which consisted of questions about demographics, internet use, the Internet Addiction Test (IAT), the Smartphone Addiction Scale (SAS)-Short Version (SV), the 25-item Hikikomori Questionnaire (HQ-25), etc. We investigated the difference and correlation of the results between two groups based on the purpose of internet use or the total score of each self-rating scale, such as screened positive or negative for the risk of internet addiction, smartphone addiction, or hikikomori. Results: There was a trend that males favored gaming in their internet use while females used the internet mainly for social networking via smartphone, and the mean SAS-SV score was higher in females. Two-group comparisons between gamers and social media users, according to the main purpose of internet use, showed that gamers used the internet longer and had significantly higher mean IAT and HQ-25 scores. Regarding hikikomori trait, the subjects at high risk for hikikomori on HQ-25 had longer internet usage time and higher scores on both IAT and SAS-SV. Correlation analyses revealed that HQ-25 and IAT scores had a relatively strong relationship, although HQ-25 and SAS-SV had a moderately weak one. Discussion: Internet technology has changed our daily lives dramatically and altered the way we communicate as well. As social media applications are becoming more popular, users are connected more tightly to the internet and their time spent with others in the real world continues to decrease. Males often isolate themselves from the social community in order to engage in online gaming while females use the internet as to not be excluded from their communications online. Mental health providers should be aware of the seriousness of internet addictions and hikikomori.

Establishing the cut-off score for aggression on the Brief Psychiatric Rating Scale-Excited Component (BPRS-EC) in schizophrenia patients
Seon Cheol Park, Eun Young Jang, Gyung Mee Kim, Ajit Avasthi, Sandeep Grover, Andi Jayalangkara Tanra, Takahiro A. Kato, Kok Yoon Chee, Mian Yoon Chong, Afzal Javed, Chay Hoon Tan, Norman Sartorius, Naotaka Shinfuku, Yong Chon Park
Psychiatry and Clinical Psychopharmacology, 01 Jan. 2019

Development and validation of the 22-item Tarumi's Modern-Type Depression Trait Scale: Avoidance of Social Roles, Complaint, and Low Self-Esteem (TACS-22)
Takahiro A. Kato, Ryoko Katsuki, Hiroaki Kubo, Norihiro Shimokawa, Mina Sato-Kasai, Kohei Hayakawa, Nobuki Kuwano, Wakako Umene-Nakano, Masaru Tateno, Daiki Setoyama, Dongchon Kang, Motoki Watabe, Shinji Sakamoto, Alan R. Teo, Shigenobu Kanba
Psychiatry and Clinical Neurosciences, 01 Jan. 2019

Comparison of the Defined Daily Dose and Chlorpromazine Equivalent Methods in Antipsychotic Drug Utilization in Six Asian Countries　　　　　　　　　　　　　　　
Takahiro A Kato
Neuropsychiatry(London), 8, 6, 1847, 1852, Dec. 2018, [Peer-reviewed]
English

Neuron-related blood inflammatory markers as an objective evaluation tool for major depressive disorder: An exploratory pilot case-control study.
Kuwano N, Kato TA, Mitsuhashi M, Sato-Kasai M, Shimokawa N, Hayakawa K, Ohgidani M, Sagata N, Kubo H, Sakurai T, Kanba S
Journal of affective disorders, 240, 88, 98, Nov. 2018, [Peer-reviewed]

Suicidal ideation and burnout among psychiatric trainees in Japan.
Masaru Tateno, Nikolina Jovanović, Julian Beezhold, Kumi Uehara-Aoyama, Wakako Umene-Nakano, Takashi Nakamae, Naoki Uchida, Naoki Hashimoto, Saya Kikuchi, Yosuke Wake, Daisuke Fujisawa, Keisuke Ikari, Kotaro Otsuka, Katsuyoshi Takahashi, Gaku Okugawa, Norio Watanabe, Tomohiro Shirasaka, Takahiro A Kato
Early intervention in psychiatry, 12, 5, 935, 937, Oct. 2018, [Peer-reviewed], [International Magazine]
English, AIM: Burnout is a psychological condition that may occur in all workers after being exposed to excessive work-related stresses. We investigated suicidal ideation and burnout among Japanese psychiatric trainees as a part of the Burnout Syndrome Study (BoSS) International. METHODS: In the Japanese branch, 91 trainees fully completed suicide ideation and behaviour questionnaire (SIBQ) and Maslach Burnout Inventory-General Survey (MBI-GS). RESULTS: Passive suicidal ideation was reported by 38.5% of Japanese trainees and 22.0% of them had experienced active suicidal ideation. The burnout rate among Japanese subjects was 40.0%. These results were worse compared to the all 1980 trainees who fully completed the main outcome measure in BoSS International, 25.9%, 20.4% and 36.7%, respectively. CONCLUSIONS: Our results suggest a higher risk of suicide among Japanese residents. Japan has a higher suicide rate than other countries. Early detection of, and appropriate intervention for, suicidal ideation is important in preventing suicide in psychiatry residents.

Development and validation of the 25-item Hikikomori Questionnaire (HQ-25).
Teo AR, Chen JI, Kubo H, Katsuki R, Sato-Kasai M, Shimokawa N, Hayakawa K, Umene-Nakano W, Aikens JE, Kanba S, Kato TA
Psychiatry and clinical neurosciences, 72, 10, 780, 788, Oct. 2018, [Peer-reviewed]

Prevalence rate of Internet addiction among Japanese college students: Two cross-sectional studies and reconsideration of cut-off points of Young's Internet Addiction Test in Japan.
Tateno M, Teo AR, Shiraishi M, Tayama M, Kawanishi C, Kato TA
Psychiatry and clinical neurosciences, 72, 9, 723, 730, Sep. 2018, [Peer-reviewed]

Cushing's Syndrome and Psychosis: A Case Report and Literature Review.
Fujii Y, Mizoguchi Y, Masuoka J, Matsuda Y, Abe T, Anzai K, Kunitake Y, Tateishi H, Inaba T, Murakawa T, Kato TA, Monji A
The primary care companion for CNS disorders, 20, 5, Sep. 2018, [Peer-reviewed]

Does LINE addiction exist? Potential concerns about Japan's most popular form of social media on smartphones.
Tateno M, Teo AR, Kato TA
Psychiatry and clinical neurosciences, 72, 7, 540, 541, Jul. 2018, [Peer-reviewed]

Internet addiction and ADHD traits among female college students in Japan
Tateno M*, Tateno Y, Kamikobe C, Monden R, Sakaoka O, Kanazawa J, Kato TA, Saito T
Journal of the Korean Academy of Child and Adolescent Psychiatry, 29, 3, 144, 148, Jul. 2018, [International Magazine]
English

Is a socio-cultural analysis of depressive disorders a matter of concern? Response to Kaiya
Takahiro A. Kato, Shigenobu Kanba
American Journal of Psychiatry, 175, 5, 483, 484, American Psychiatric Association, 01 May 2018, [Peer-reviewed]
English

Harnessing social media to explore youth social withdrawal in three major cities in China: Cross-sectional web survey
Lucia Lin Liu, Tim MH Li, Alan R Teo, Takahiro A Kato, Paul WC Wong
Journal of Medical Internet Research, 20, 5, e34, Journal of Medical Internet Research, 01 May 2018, [Peer-reviewed]
English

Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder: An exploratory pilot case-control study
Nobuki Kuwano, Takahiro A. Kato, Daiki Setoyama, Mina Sato-Kasai, Norihiro Shimokawa, Kohei Hayakawa, Masahiro Ohgidani, Noriaki Sagata, Hiroaki Kubo, Junji Kishimoto, Dongchon Kang, Shigenob Kanba
Journal of Affective Disorders, 231, 74, 82, Elsevier B.V., 15 Apr. 2018, [Peer-reviewed]
English, Scientific journal

Early-onset epileptic encephalopathy and severe developmental delay in an association with de novo double mutations in NF1 and MAGEL2.
Akamine S, Sagata N, Sakai Y, Kato TA, Nakahara T, Matsushita Y, Togao O, Hiwatashi A, Sanefuji M, Ishizaki Y, Torisu H, Saitsu H, Matsumoto N, Hara T, Sawa A, Kano S, Furue M, Kanba S, Shaw CA, Ohga S
Epilepsia open, 3, 1, 81, 85, Mar. 2018, [Peer-reviewed]

Lamotrigine Rechallenge in Treatment-Resistant Bipolar Disorder.
Inaba T, Sogawa R, Mizoguchi Y, Tateishi H, Kunitake Y, Kato TA, Monji A
The primary care companion for CNS disorders, 20, 2, Mar. 2018, [Peer-reviewed]

p66Shc Signaling Mediates Diabetes-Related Cognitive Decline.
Yohei Minami, Noriyuki Sonoda, Eiichi Hayashida, Hiroaki Makimura, Makoto Ide, Noriko Ikeda, Masahiro Ohgidani, Takahiro A Kato, Yoshihiro Seki, Yasutaka Maeda, Shigenobu Kanba, Ryoichi Takayanagi, Yoshihiro Ogawa, Toyoshi Inoguchi
Scientific reports, 8, 1, 3213, 3213, 16 Feb. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, Accumlating evidence have suggested that diabetes mellitus links dementia, notably of Alzheimer's disease (AD). However, the underlying mechanism remains unclear. Several studies have shown oxidative stress (OS) to be one of the major factors in the pathogenesis of diabetic complications. Here we show OS involvement in brain damage in a diabetic animal model that is at least partially mediated through an AD-pathology-independent mechanism apart from amyloid-β accumulation. We investigated the contribution of the p66Shc signaling pathway to diabetes-related cognitive decline using p66Shc knockout (-/-) mice. p66Shc (-/-) mice have less OS in the brain and are resistant to diabetes-induced brain damage. Moreover, p66Shc (-/-) diabetic mice show significantly less cognitive dysfunction and decreased levels of OS and the numbers of microglia. This study postulates a p66Shc-mediated inflammatory cascade leading to OS as a causative pathogenic mechanism in diabetes-associated cognitive impairment that is at least partially mediated through an AD-pathology-independent mechanism.

Blood biomarkers of Hikikomori, a severe social withdrawal syndrome.
Kohei Hayakawa, Takahiro A Kato, Motoki Watabe, Alan R Teo, Hideki Horikawa, Nobuki Kuwano, Norihiro Shimokawa, Mina Sato-Kasai, Hiroaki Kubo, Masahiro Ohgidani, Noriaki Sagata, Hiroyuki Toda, Masaru Tateno, Naotaka Shinfuku, Junji Kishimoto, Shigenobu Kanba
Scientific reports, 8, 1, 2884, 2884, 13 Feb. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, Hikikomori, a severe form of social withdrawal syndrome, is a growing social issue in Japan and internationally. The pathophysiology of hikikomori has not yet been elucidated and an effective treatment remains to be established. Recently, we revealed that avoidant personality disorder is the most common comorbidity of hikikomori. Thus, we have postulated that avoidant personality is the personality underpinning hikikomori. First, we herein show relationships between avoidant personality traits, blood biomarkers, hikikomori-related psychological features, and behavioural characteristics assessed by a trust game in non-hikikomori volunteers. Avoidant personality traits were negatively associated with high-density lipoprotein cholesterol (HDL-C) and uric acid (UA) in men, and positively associated with fibrin degeneration products (FDP) and high sensitivity C-reactive protein (hsCRP) in women. Next, we recruited actual individuals with hikikomori, and compared avoidant personality traits, blood biomarkers, and psychological features between individuals with hikikomori and age-matched healthy controls. Individuals with hikikomori had higher avoidant personality scores in both sexes, and showed lower serum UA levels in men and lower HDL-C levels in women compared with healthy controls. This is the first report showing possible blood biomarkers for hikikomori, and opens the door to clarify the underlying biological pathophysiology of hikikomori.

Hikikomori: experience in Japan and international relevance
Takahiro A. Kato, Shigenobu Kanba, Alan R. Teo
World Psychiatry, 17, 1, 105, 106, Blackwell Publishing Ltd, 01 Feb. 2018, [Peer-reviewed]
English

Development of a 2-h suicide prevention program for medical staff including nurses and medical residents: A two-center pilot trial.
Yukako Nakagami, Hiroaki Kubo, Ryoko Katsuki, Tomomichi Sakai, Genichi Sugihara, Chisako Naito, Hiroyuki Oda, Kohei Hayakawa, Yuriko Suzuki, Daisuke Fujisawa, Naoki Hashimoto, Keiji Kobara, Tetsuji Cho, Hironori Kuga, Kiyoshi Takao, Yoko Kawahara, Yumi Matsumura, Toshiya Murai, Koichi Akashi, Shigenobu Kanba, Kotaro Otsuka, Takahiro A Kato
Journal of affective disorders, 225, 569, 576, 01 Jan. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Suicide is a crucial global health concern and effective suicide prevention has long been warranted. Mental illness, especially depression is the highest risk factor of suicide. Suicidal risk is increased in people not only with mental illness but also with physical illnesses, thus medical staff caring for physically-ill patients are also required to manage people with suicidal risk. In the present study, we evaluated our newly developed suicide intervention program among medical staff. METHODS: We developed a 2-h suicide intervention program for medical staff, based on the Mental Health First Aid (MHFA), which had originally been developed for the general population. We conducted this program for 74 medical staff members from 2 hospitals. Changes in knowledge, perceived skills, and confidence in early intervention of depression and suicide-prevention were evaluated using self-reported questionnaires at 3 points; pre-program, immediately after the program, and 1 month after program. RESULTS: This suicide prevention program had significant effects on improving perceived skills and confidence especially among nurses and medical residents. These significant effects lasted even 1 month after the program. LIMITATIONS: Design was a single-arm study with relatively small sample size and short-term follow up. CONCLUSIONS: The present study suggests that the major target of this effective program is nurses and medical residents. Future research is required to validate the effects of the program with control groups, and also to assess long-term effectiveness and actual reduction in suicide rates.

Second-Generation Antipsychotic-Induced Hypoglycemia.
Fujita T, Mizoguchi Y, Kunitake Y, Tateishi H, Inaba T, Kato TA, Monji A
The primary care companion for CNS disorders, 20, 1, Jan. 2018, [Peer-reviewed]

Development of MHFA-based 2-h educational program for early intervention in depression among office workers: A single-arm pilot trial.
Hiroaki Kubo, Hiromi Urata, Ryoko Katsuki, Miyako Hirashima, Shion Ueno, Yuriko Suzuki, Daisuke Fujisawa, Naoki Hashimoto, Keiji Kobara, Tetsuji Cho, Toshiko Mitsui, Shigenobu Kanba, Kotaro Otsuka, Takahiro A Kato
PloS one, 13, 12, e0208114, 2018, [International Magazine]
English, Scientific journal

Comparison of treatment patterns in schizophrenia between China and Japan (2001-2009)
Yu-Tao Xiang, Takahiro A. Kato, Taishiro Kishimoto, Gabor S. Ungvari, Helen F. K. Chiu, Tian-Mei Si, Shu-Yu Yang, Senta Fujii, Chee H. Ng, Naotaka Shinfuku
ASIA-PACIFIC PSYCHIATRY, 9, 4, Dec. 2017, [Peer-reviewed]
English, Scientific journal

Does hikikomori (severe social withdrawal) exist among young people in urban areas of China?
Paul W.C. Wong, Lucia L. Liu, Tim M.H. Li, Takahiro A. Kato, Alan R. Teo
Asian Journal of Psychiatry, 30, 175, 176, Elsevier B.V., 01 Dec. 2017, [Peer-reviewed]
English

Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia
Yoshinori Haraguchi, Yoshito Mizoguchi, Masahiro Ohgidani, Yoshiomi Imamura, Toru Murakawa-Hirachi, Hiromi Nabeta, Hiroshi Tateishi, Takahiro A. Kato, Akira Monji
JOURNAL OF NEUROINFLAMMATION, 14, 1, 258, Dec. 2017, [Peer-reviewed]
English, Scientific journal

Modern-Type Depression as an "Adjustment" Disorder in Japan: The Intersection of Collectivistic Society Encountering an Individualistic Performance-Based System
Takahiro A. Kato, Shigenobu Kanba
AMERICAN JOURNAL OF PSYCHIATRY, 174, 11, 1051, 1053, Nov. 2017, [Peer-reviewed]
English, Scientific journal

Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study
Noriaki Sagata, Takahiro A. Kato, Shin-ichi Kano, Masahiro Ohgidani, Norihiro Shimokawa, Mina Sato-Kasai, Kohei Hayakawa, Nobuki Kuwano, Ashley M. Wilson, Koko Ishizuka, Shiori Kato, Takeshi Nakahara, Makiko Nakahara-Kido, Daiki Setoyama, Yasunari Sakai, Shouichi Ohga, Masutaka Furue, Akira Sawa, Shigenobu Kanba
SCIENTIFIC REPORTS, 7, 1, 13905, Oct. 2017, [Peer-reviewed]
English, Scientific journal

Translational research on neuropsychiatrie disorders: Focusing on microglia hypothesis
Takahiro A. Kato, Masahiro Ohgidani, Shigenobu Kanba
Brain and Nerve, 69, 9, 1007, 1015, Igaku-Shoin Ltd, 01 Sep. 2017, [Peer-reviewed]
Japanese, Scientific journal

Fibromyalgia and microglial TNF-alpha: Translational research using human blood induced microglia-like cells
Masahiro Ohgidani, Takahiro A. Kato, Masako Hosoi, Makoto Tsuda, Kohei Hayakawa, Chie Hayaki, Rie Iwaki, Noriaki Sagata, Ryota Hashimoto, Kazuhide Inoue, Nobuyuki Sudo, Shigenobu Kanba
SCIENTIFIC REPORTS, 7, 1, 11882, Sep. 2017, [Peer-reviewed]
English, Scientific journal

Effect of Excessive Coffee Consumption on the Clinical Course of a Patient With Bipolar Disorder: A Case Report and Literature Review
Yutaka Kunitake, Yoshito Mizoguchi, Rintaro Sogawa, Jun Matsushima, Takahiro A. Kato, Toshiro Kawashima, Akira Monji
CLINICAL NEUROPHARMACOLOGY, 40, 4, 160, 162, Jul. 2017, [Peer-reviewed]
English

Progressive brain atrophy and cognitive decline along with multiple episodes of delirium
Kohei Hayakawa, Takahiro A. Kato, Shigeru Imamura, Naofumi Kasai, Shigenobu Kanba
PSYCHIATRY AND CLINICAL NEUROSCIENCES, 71, 6, 418, 419, Jun. 2017, [Peer-reviewed]
English

Microglia-derived neuregulin expression in psychiatric disorders.
Daisuke Ikawa, Manabu Makinodan, Keiko Iwata, Masahiro Ohgidani, Takahiro A Kato, Yasunori Yamashita, Kazuhiko Yamamuro, Sohei Kimoto, Michihiro Toritsuka, Takahira Yamauchi, Shin-Ichi Fukami, Hiroki Yoshino, Kazuki Okumura, Tatsuhide Tanaka, Akio Wanaka, Yuji Owada, Masatsugu Tsujii, Toshiro Sugiyama, Kenji Tsuchiya, Norio Mori, Ryota Hashimoto, Hideo Matsuzaki, Shigenobu Kanba, Toshifumi Kishimoto
Brain, behavior, and immunity, 61, 375, 385, Mar. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, Several studies have revealed that neuregulins (NRGs) are involved in brain function and psychiatric disorders. While NRGs have been regarded as neuron- or astrocyte-derived molecules, our research has revealed that microglia also express NRGs, levels of which are markedly increased in activated microglia. Previous studies have indicated that microglia are activated in the brains of individuals with autism spectrum disorder (ASD). Therefore, we investigated microglial NRG mRNA expression in multiple lines of mice considered models of ASD. Intriguingly, microglial NRG expression significantly increased in BTBR and socially-isolated mice, while maternal immune activation (MIA) mice exhibited identical NRG expression to controls. Furthermore, we observed a positive correlation between NRG expression in microglia and peripheral blood mononuclear cells (PBMCs) in mice, suggesting that NRG expression in human PBMCs may mirror microglia-derived NRG expression in the human brain. To translate these findings for application in clinical psychiatry, we measured levels of NRG1 splice-variant expression in clinically available PBMCs of patients with ASD. Levels of NRG1 type III expression in PBMCs were positively correlated with impairments in social interaction in children with ASD (as assessed using the Autistic Diagnostic Interview-Revised test: ADI-R). These findings suggest that immune cell-derived NRGs may be implicated in the pathobiology of psychiatric disorders such as ASD.

Can Pokemon GO rescue shut-ins (hikikomori) from their isolated world?
Takahiro A. Kato, Alan R. Teo, Masaru Tateno, Motoki Watabe, Hiroaki Kubo, Shigenobu Kanba
PSYCHIATRY AND CLINICAL NEUROSCIENCES, 71, 1, 75, 76, Jan. 2017, [Peer-reviewed]
English

Microglial CD206 Gene Has Potential as a State Marker of Bipolar Disorder
Masahiro Ohgidani, Takahiro A. Kato, Yoshinori Haraguchi, Toshio Matsushima, Yoshito Mizoguchi, Toru Murakawa-Hirachi, Noriaki Sagata, Akira Monji, Shigenobu Kanba
FRONTIERS IN IMMUNOLOGY, 7, 676, Jan. 2017, [Peer-reviewed]
English, Scientific journal

Aripiprazole inhibits polyI: C-induced microglial activation possibly via TRPM7
Mina Sato-Kasai, Takahiro A. Kato, Masahiro Ohgidani, Yoshito Mizoguchi, Noriaki Sagata, Shogo Inamine, Hideki Horikawa, Kohei Hayakawa, Norihiro Shimokawa, Sota Kyuragi, Yoshihiro Seki, Akira Monji, Shigenobu Kanba
SCHIZOPHRENIA RESEARCH, 178, 1-3, 35, 43, Dec. 2016, [Peer-reviewed]
English, Scientific journal

Internet addiction and self-evaluated attention-deficit hyperactivity disorder traits among Japanese college students
Masaru Tateno, Alan R. Teo, Tomohiro Shirasaka, Masaya Tayama, Motoki Watabe, Takahiro A. Kato
PSYCHIATRY AND CLINICAL NEUROSCIENCES, 70, 12, 567, 572, Dec. 2016, [Peer-reviewed]
English, Scientific journal

New game software (Pokemon Go) may help youth with severe social withdrawal, hikikomori
Masaru Tateno, Norbert Skokauskas, Takahiro A. Kato, Alan R. Teo, Anthony P. S. Guerrero
PSYCHIATRY RESEARCH, 246, 848, 849, Dec. 2016, [Peer-reviewed]
English

Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis
Daiki Setoyama, Takahiro A. Kato, Ryota Hashimoto, Hiroshi Kunugi, Kotaro Hattori, Kohei Hayakawa, Mina Sato-Kasai, Norihiro Shimokawa, Sachie Kaneko, Sumiko Yoshida, Yu-ichi Goto, Yuka Yasuda, Hidenaga Yamamori, Masahiro Ohgidani, Noriaki Sagata, Daisuke Miura, Dongchon Kang, Shigenobu Kanba
PLOS ONE, 11, 12, e0165267, Dec. 2016, [Peer-reviewed]
English, Scientific journal

A patient with Alzheimer's disease complicated by elderly-onset Cushing's syndrome who had undergone surgical treatment for adrenocorticotropic hormone-independent macronodular adrenal hyperplasia
Yoshinori Haraguchi, Yoshito Mizoguchi, Tomoyuki Noguchi, Takeo Arai, Junko Fukuyama, Takahiro A. Kato, Toshiro Kawashima, Akira Monji
PSYCHOGERIATRICS, 16, 4, 274, 276, Jul. 2016, [Peer-reviewed]
English, Scientific journal

Abnormal behaviours during pramipexole treatment for Cotard's syndrome: a case report
Joji Maruo, Yoshinori Haraguchi, Hiroshi Tateishi, Tomoyuki Noguchi, Yoshito Mizoguchi, Takahiro A. Kato, Toshiro Kawashima, Akira Monji
PSYCHOGERIATRICS, 16, 4, 283, 286, Jul. 2016, [Peer-reviewed]
English, Scientific journal

TNF-alpha from hippocampal microglia induces working memory deficits by acute stress in mice
Masahiro Ohgidani, Takahiro A. Kato, Noriaki Sagata, Kohei Hayakawa, Norihiro Shimokawa, Mina Sato-Kasai, Shigenobu Kanba
BRAIN BEHAVIOR AND IMMUNITY, 55, 17, 24, Jul. 2016, [Peer-reviewed]
English, Scientific journal

A 39-Year-Old "Adultolescent": Understanding Social Withdrawal in Japan
Takahiro A. Kato, Shigenobu Kanba, Alan R. Teo
AMERICAN JOURNAL OF PSYCHIATRY, 173, 2, 112, 114, Feb. 2016, [Peer-reviewed]
English

Effectiveness of suicide prevention gatekeeper-training for university administrative staff in Japan.
Naoki Hashimoto, Yuriko Suzuki, Takahiro A Kato, Daisuke Fujisawa, Ryoko Sato, Kumi Aoyama-Uehara, Maiko Fukasawa, Satoshi Asakura, Ichiro Kusumi, Kotaro Otsuka
Psychiatry and clinical neurosciences, 70, 1, 62, 70, Jan. 2016, [Peer-reviewed], [International Magazine]
English, AIMS: Suicide is a leading cause of death among Japanese college and university students. Gatekeeper-training programs have been shown to improve detection and referral of individuals who are at risk of suicide by training non-mental-health professional persons. However, no studies have investigated the effectiveness of such programs in university settings in Japan. The aim of this study was to investigate the effectiveness of the gatekeeper-training program for administrative staff in Japanese universities. METHODS: We developed a 2.5-h gatekeeper-training program based on the Mental Health First Aid program, which was originally developed for the general public. Seventy-six administrative staff at Hokkaido University participated in the program. Competence and confidence in managing suicide intervention, behavioral intention as a gatekeeper and attitude while handling suicidal students were measured by a self-reported questionnaire before, immediately after and a month after the program. RESULTS: We found a significant improvement in competence in the management of suicidal students. We also found improvements in confidence in management of suicidal students and behavioral intention as a gatekeeper after training, though questionnaires for those secondary outcomes were not validated. These improvements continued for a month. About 95% of the participants rated the program as useful or very useful and one-third of the participants had one or more chances to utilize their skills within a month. CONCLUSIONS: The current results suggest the positive effects of the training program in university settings in Japan. Future evaluation that includes comparison with standard didactic trainings and an assessment of long-term effectiveness are warranted.

Neurocognitive Disorders in Chronic Kidney Disease: A Case Report and Literature Review
Hiroshi Tateishi, Toru Hirachi, Joji Maruo, Yoshinori Haraguchi, Tomoyuki Noguchi, Yoshito Mizoguchi, Takahiro A. Kato, Toshiro Kawashima, Akira Monji
PSYCHOSOMATICS, 57, 1, 107, 112, Jan. 2016, [Peer-reviewed]
English, Scientific journal

Boundless syndromes in modern society: An interconnected world producing novel psychopathology in the 21st century
Takahiro A. Kato, Shigenobu Kanba
PSYCHIATRY AND CLINICAL NEUROSCIENCES, 70, 1, 1, 2, Jan. 2016, [Peer-reviewed]
English

Mania occurring during systemic lupus erythematosus relapse and its amelioration on clinical and neuroimaging follow-up
T. Hirachi, H. Ishii, Y. Tada, T. Noguchi, Y. Haraguchi, H. Tateishi, Y. Mizoguchi, T. A. Kato, T. Kawashima, A. Monji
Lupus, 24, 9, 990, 993, SAGE Publications Ltd, 25 Aug. 2015, [Peer-reviewed]
English, Scientific journal

Psychopathology associated with social withdrawal: Idiopathic and comorbid presentations
Alan R. Teo, Somnath Saha, Kyle Stufflebam, Michael D. Fetters, Masaru Tateno, Shigenobu Kanba, Takahiro A. Kato
PSYCHIATRY RESEARCH, 228, 1, 182, 183, Jul. 2015, [Peer-reviewed]
English

Redox and Microglia in the Pathophysiology of Schizophrenia
Takahiro A. Kato, Fuminori Hyodo, Mayumi Yamato, Hideo Utsumi, Shigenobu Kanba
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 135, 5, 739, 743, May 2015, [Peer-reviewed]
Japanese

MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia
Paul C. Guest, Keiko Iwata, Takahiro A. Kato, Johann Steiner, Andrea Schmitt, Christoph W. Turck, Daniel Martins-de-Souza
FRONTIERS IN CELLULAR NEUROSCIENCE, 9, 180, May 2015, [Peer-reviewed]
English, Scientific journal

Relationship between Trusting Behaviors and Psychometrics Associated with Social Network and Depression among Young Generation: A Pilot Study
Motoki Watabe, Takahiro A. Kato, Alan R. Teo, Hideki Horikawa, Masaru Tateno, Kohei Hayakawa, Norihiro Shimokawa, Shigenobu Kanba
PLOS ONE, 10, 4, e0120183, Apr. 2015, [Peer-reviewed]
English, Scientific journal

Identification of the hikikomori syndrome of social withdrawal: Psychosocial features and treatment preferences in four countries
Alan R. Teo, Michael D. Fetters, Kyle Stufflebam, Masaru Tateno, Yatan Balhara, Tae Young Choi, Shigenobu Kanba, Carol A. Mathews, Takahiro A. Kato
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY, 61, 1, 64, 72, Feb. 2015, [Peer-reviewed]
English, Scientific journal

The prevalence and correlates of severe social withdrawal in Hong Kong
Alan R. Teo, Takahiro A. Kato
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY, 61, 1, 102, 102, Feb. 2015, [Peer-reviewed]
English

Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: Studies of lysosomal storage diseases and channelopathy
S. Kano, M. Yuan, R. A. Cardarelli, G. Maegawa, N. Higurashi, M. Gaval-Cruz, A. M. Wilson, C. Tristan, M. A. Kondo, Y. Chen, M. Koga, C. Obie, K. Ishizuka, S. Seshadri, R. Srivastava, T. A. Kato, Y. Horiuchi, T. W. Sedlak, Y. Lee, J. L. Rapoport, S. Hirose, H. Okano, D. Valle, P. O’Donnell, A. Sawa, M. Kai
Current Molecular Medicine, 15, 2, 138, 145, Bentham Science Publishers B.V., 2015, [Peer-reviewed]
English, Scientific journal

Microglial intracellular Ca2+ signaling as a target of antipsychotic actions for the treatment of schizophrenia
Yoshito Mizoguchi, Takahiro A. Kato, Hideki Horikawa, Akira Monji
FRONTIERS IN CELLULAR NEUROSCIENCE, 8, 370, Nov. 2014, [Peer-reviewed]
English

Anti-allergic mechanisms of Japanese herbal medicine, yokukansan on mast cells
Kazuhiko Yamamura, Shiori Kato, Takahiro A. Kato, Yoshito Mizoguchi, Akira Monji, Shigenobu Kanba, Masutaka Furue, Satoshi Takeuchi
JOURNAL OF DERMATOLOGY, 41, 9, 808, 814, Sep. 2014, [Peer-reviewed]
English, Scientific journal

Brain-derived Neurotrophic Factor (BDNF) Induces Sustained Intracellular Ca2+ Elevation through the Up-regulation of Surface Transient Receptor Potential 3 (TRPC3) Channels in Rodent Microglia
Yoshito Mizoguchi, Takahiro A. Kato, Yoshihiro Seki, Masahiro Ohgidani, Noriaki Sagata, Hideki Horikawa, Yusuke Yamauchi, Mina Sato-Kasai, Kohei Hayakawa, Ryuji Inoue, Shigenobu Kanba, Akira Monji
JOURNAL OF BIOLOGICAL CHEMISTRY, 289, 26, 18549, 18555, Jun. 2014, [Peer-reviewed]
English, Scientific journal

Effectiveness of brief suicide management training program for medical residents in Japan: A cluster randomized controlled trial　　　　　　　　　　　　　　　
Suzuki Y, Kato TA, Sato R, Fujisawa D, Aoyama-Uehara K, Hashimoto N, Yonemoto N, Fukasawa M, Otsuka K
Epidemiology and Psychiatric Sciences, 23, 2, 167, 176, Jun. 2014, [Peer-reviewed]
English

Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease
Masahiro Ohgidani, Takahiro A. Kato, Daiki Setoyama, Noriaki Sagata, Ryota Hashimoto, Kazue Shigenobu, Tetsuhiko Yoshida, Kohei Hayakawa, Norihiro Shimokawa, Daisuke Miura, Hideo Utsumi, Shigenobu Kanba
SCIENTIFIC REPORTS, 4, 4957, May 2014, [Peer-reviewed]
English, Scientific journal

Minocycline, a Microglial Inhibitor, Diminishes Terminal Patients' Delirium?
Kohei Hayakawa, Takahiro A. Kato, Masaomi Kohjiro, Akira Monji, Shigenobu Kanba
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 22, 3, 314, 315, Mar. 2014, [Peer-reviewed]
English

Why medical students choose psychiatry - A 20 country cross-sectional survey
Kitty Farooq, Gregory J Lydall, Amit Malik, David M Ndetei, ISOSCCIP Group, Dinesh Bhugra, Yonas Baheretibeb Alemu, Sammy Ohene, Muthoni Mathai, Benson Gakinya, Richard Uwakwa, Femi Olugbile, Kiyeti Hauli, Joyce Mugaza, Gad Kilonzo, Seggane Musisi, Samuel Maling, Paul Ravi, Rubens Luis Folchini Fernandes, Luiz Antonio Nogueira-Martins, Jair de Jesus Mari, Sergio Baldassin, Nilson Rodrigues da Silva, Karen Saperson, Martina Rojnic Kuzman, Petra Lovrec, Mia Smoljan, Benjamin Vicente, Leonardo Rosel, Alexander Nawka, Lucie Nawkova, Boris Dvoracek, Olivier Andlauer, Emmanuel Haffen, Daniel Sechter, William Guicherd, Bernard Bonin, Iris Tatjana Calliess, Volkhard Fischer, Anke Mittelstädt, Vanessa Wong, P. S.V.N. Sharma, Sumit Deora, Suma Udupa, A-Rasoul Yasiri, Basil Al-Chalabi, Ali Al-Hamzawi, Sirwan Ali, Akeel Al-Sabbagh, Eyal Dahan, Karin Schlossberg, Silvia Ferrari, Corinna Reggianini, Giorgio Mattei, Luca Pingani, Takahiro A. Kato, Shigenobu Kanba, Masaru Tateno, Soraya Seedat, Sharain Suliman, Wolfgang Gerke, Ulrich Schnyder, François Ferrero, Guido Bondolf, Neel Halder, Christiana Hadjidemetriou, Rachel Pearson
BMC Medical Education, 14, 1, BioMed Central Ltd., 15 Jan. 2014, [Peer-reviewed]
English, Scientific journal

Pretreatment of aripiprazole and minocycline, but not haloperidol, suppresses oligodendrocyte damage from interferon-gamma-stimulated microglia in co-culture model
Yoshihiro Seki, Takahiro A. Kato, Akira Monji, Yoshito Mizoguchi, Hideki Horikawa, Mina Sato-Kasai, Daigo Yoshiga, Shigenobu Kanba
SCHIZOPHRENIA RESEARCH, 151, 1-3, 20, 28, Dec. 2013, [Peer-reviewed]
English, Scientific journal

Suicide Intervention Skills Among Japanese Medical Residents
Daisuke Fujisawa, Yuriko Suzuki, Takahiro A. Kato, Naoki Hashimoto, Ryoko Sato, Kumi Aoyama-Uehara, Maiko Fukasawa, Masayuki Tomita, Koichiro Watanabe, Haruo Kashima, Kotaro Otsuka
ACADEMIC PSYCHIATRY, 37, 6, 402, 407, Nov. 2013, [Peer-reviewed]
English, Scientific journal

Undergraduate medical students' attitudes towards psychiatry: An international cross-sectional survey between India and Japan
Takahiro A. Kato, Yatan Pal Singh Balhara, Jatinder Mohan Chawla, Masaru Tateno, Shigenobu Kanba
INTERNATIONAL REVIEW OF PSYCHIATRY, 25, 4, 378, 384, Aug. 2013, [Peer-reviewed]
English, Scientific journal

Minocycline, a microglial inhibitor, reduces 'honey trap' risk in human economic exchange
Motoki Watabe, Takahiro A. Kato, Sho Tsuboi, Katsuhiko Ishikawa, Kazuhide Hashiya, Akira Monji, Hideo Utsumi, Shigenobu Kanba
Scientific Reports, 3, 1685, Nature Publishing Group, 18 Apr. 2013, [Peer-reviewed]
English, Scientific journal

Neuroinflammation in schizophrenia especially focused on the role of microglia
Akira Monji, Takahiro A. Kato, Yoshito Mizoguchi, Hideki Horikawa, Yoshihiro Seki, Mina Kasai, Yusuke Yamauchi, Shigeto Yamada, Shigenobu Kanba
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 42, 115, 121, Apr. 2013, [Peer-reviewed]
English, Scientific journal

Nationwide Survey of Work Environment, Work-Life Balance and Burnout among Psychiatrists in Japan
Wakako Umene-Nakano, Takahiro A. Kato, Saya Kikuchi, Masaru Tateno, Daisuke Fujisawa, Tsutomu Hoshuyama, Jun Nakamura
PLOS ONE, 8, 2, e55189, Feb. 2013, [Peer-reviewed]
English, Scientific journal

FTD with catatonia-like signs that temporarily resolved with zolpidem
Shuichi Isomura, Akira Monji, Kensuke Sasaki, Shingo Baba, Toshiaki Onitsuka, Tomoyuki Ohara, Yoshito Mizoguchi, Takahiro A. Kato, Hideki Horikawa, Yoshihiro Seki, Shigenobu Kanba
Neurology: Clinical Practice, 3, 4, 354, 357, Lippincott Williams and Wilkins, 2013, [Peer-reviewed]
English, Scientific journal

Hikikomori as a possible clinical term in psychiatry: a questionnaire survey
Masaru Tateno, Tae Woo Park, Takahiro A. Kato, Wakako Umene-Nakano, Toshikazu Saito
BMC PSYCHIATRY, 12, 169, Oct. 2012, [Peer-reviewed]
English, Scientific journal

Does the 'hikikomori' syndrome of social withdrawal exist outside Japan? A preliminary international investigation
Takahiro A. Kato, Masaru Tateno, Naotaka Shinfuku, Daisuke Fujisawa, Alan R. Teo, Norman Sartorius, Tsuyoshi Akiyama, Tetsuya Ishida, Tae Young Choi, Yatan Pal Singh Balhara, Ryohei Matsumoto, Wakako Umene-Nakano, Yota Fujimura, Anne Wand, Jane Pei-Chen Chang, Rita Yuan-Feng Chang, Behrang Shadloo, Helal Uddin Ahmed, Tiraya Lerthattasilp, Shigenobu Kanba
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY, 47, 7, 1061, 1075, Jul. 2012, [Peer-reviewed]
English, Scientific journal

Minocycline Modulates Human Social Decision-Making: Possible Impact of Microglia on Personality-Oriented Social Behaviors
Takahiro A. Kato, Motoki Watabe, Sho Tsuboi, Katsuhiko Ishikawa, Kazuhide Hashiya, Akira Monji, Hideo Utsumi, Shigenobu Kanba
PLOS ONE, 7, 7, e40461, Jul. 2012, [Peer-reviewed]
English, Scientific journal

Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction?
Motoki Watabe, Takahiro A. Kato, Akira Monji, Hideki Horikawa, Shigenobu Kanba
PSYCHOPHARMACOLOGY, 220, 3, 551, 557, Apr. 2012, [Peer-reviewed]
English, Scientific journal

Introducing the concept of modern depression in Japan; an international case vignette survey
Takahiro A. Kato, Naotaka Shinfuku, Daisuke Fujisawa, Masaru Tateno, Tetsuya Ishida, Tsuyoshi Akiyama, Norman Sartorius, Alan R. Teo, Tae Young Choi, Anne P. F. Wand, Yatan Pal Singh Balhara, Jane Pei-Chen Chang, Rita Yuan-Feng Chang, Behrang Shadloo, Helal Uddin Ahmed, Tiraya Lerthattasilp, Wakako Umene-Nakano, Hideki Horikawa, Ryohei Matsumoto, Hironori Kuga, Masuo Tanaka, Shigenobu Kanba
JOURNAL OF AFFECTIVE DISORDERS, 135, 1-3, 66, 76, Dec. 2011, [Peer-reviewed]
English, Scientific journal

Visual and auditory hallucinations during normal use of paroxetine for treatment of major depressive disorder.
Monji A, Kato T, Mizoguchi Y, Horikawa H, Seki Y, Kanba S
The Journal of neuropsychiatry and clinical neurosciences, 23, E14, 5, 4, Oct. 2011, [Peer-reviewed]

Are Japan's hikikomori and depression in young people spreading abroad?
Takahiro A. Kato, Naotaka Shinfuku, Norman Sartorius, Shigenobu Kanba
LANCET, 378, 9796, 1070, 1070, Sep. 2011, [Peer-reviewed]
English

Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: Implication for antioxidative psychotropic actions via microglia
Takahiro A. Kato, Akira Monji, Keiji Yasukawa, Yoshito Mizoguchi, Hideki Horikawa, Yoshihiro Seki, Sadayuki Hashioka, Youn-Hee Han, Mina Kasai, Noriyuki Sonoda, Eiichi Hirata, Yasutaka Maeda, Toyoshi Inoguchi, Hideo Utsumi, Shigenobu Kanba
SCHIZOPHRENIA RESEARCH, 129, 2-3, 172, 182, Jul. 2011, [Peer-reviewed]
English, Scientific journal

[Views on the new psychiatric specialist certification system from the perspective of those experiencing the postgraduate psychiatric training system in Japan].
Umene-Nakano W, Uchida N, Kato T, Tateno M, Matsumoto R, Nakamura J
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 113, 3, 271, 276, Jan. 2011, [Peer-reviewed]

Differences in the preferred antipsychotics for acute schizophrenia among young psychiatrists in two regions of Japan
Masaru Tateno, Takahiro Kato, Wakako Nakano, Shigenobu Kanba, Jun Nakamura, Toshikazu Saito
Asian Journal of Psychiatry, 3, 2, 60, 63, Jun. 2010
English, Scientific journal

Impact of biopsychosocial factors on psychiatric training in Japan and overseas: Are psychiatrists oriented to mind, brain, or sociocultural issues?
Takahiro A. Kato, Masaru Tateno, Wakako Umene-Nakano, Yatan P. S. Balhara, Alan R. Teo, Daisuke Fujisawa, Ryuji Sasaki, Tetsuya Ishida, Shigenobu Kanba
PSYCHIATRY AND CLINICAL NEUROSCIENCES, 64, 5, 520, 530, Apr. 2010
English, Scientific journal

Attitudes of early-career psychiatrists in Japan toward child and adolescent psychiatry and their career decision
Masaru Tateno, Takahiro Kato, Wakako Nakano, Alan R. Teo, Atsuo Nakagawa, Kaya Miyajima, Shigenobu Kanba, Jun Nakamura, Toshikazu Saito
PSYCHIATRY AND CLINICAL NEUROSCIENCES, 64, 2, 199, 201, Apr. 2010
English, Scientific journal

[Issues and the current situation of the new compulsory residency training program in Japan: the results of an attitude survey for young career psychiatrists].
Umene-Nakano W, Kato T, Tateno M, Hoshuyama T, Nakamura J
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 112, 4, 325, 335, Apr. 2010, [Peer-reviewed]

Differences in the preferred route of administration of haloperidol for acute schizophrenia among young psychiatrists in two regions of Japan.　　　　　　　　　　　　　　　
Tateno M, Kato T, Nakano W, Kanba S, Nakamura J, Saito T
Asian Journal of Psychiatry, 3.0, Jan. 2010, [Peer-reviewed], [International Magazine]
English

Brain-Derived Neurotrophic Factor Induces Sustained Elevation of Intracellular Ca2+ in Rodent Microglia
Yoshito Mizoguchi, Akira Monji, Takahiro Kato, Yoshihiro Seki, Leo Gotoh, Hideki Horikawa, Satoshi O. Suzuki, Toru Iwaki, Miyuki Yonaha, Sadayuki Hashioka, Shigenobu Kanba
JOURNAL OF IMMUNOLOGY, 183, 12, 7778, 7786, Dec. 2009
English, Scientific journal

[Re-evaluation of the "road to becoming a psychiatrist"--learning from the interaction with young psychiatrists from overseas].
Kato T, Tateno M, Nakano W, Balhara YP, Teo RT, Fujisawa D, Sasaki R, Uchida M
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 111, 10, 1226, 1233, Oct. 2009, [Peer-reviewed]

Attitude of young psychiatrists toward coercive measures in psychiatry: A case vignette study in Japan　　　　　　　　　　　　　　　
Masaru Tateno, Kanna Sugiura, Kumi Uehara, Daisuke Fujisawa, Yueren Zhao, Naoki Hashimoto, Hidehiko Takahashi, Naofumi Yoshida, Takahiro Kato, Wakako Nakano, Yosuke Wake, Tomohiro Shirasaka, Seiju Kobayashi, Soichiro Sato
International Journal of Mental Health Systems, 3(1), 20, 22 Sep. 2009, [Peer-reviewed]
English

Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease
Akira Monji, Masashi Takita, Takaaki Samejima, Toshihiro Takaishi, Kazuhito Hashimoto, Hiroyuki Matsunaga, Mariko Oda, Yasuhisa Sumida, Yoshito Mizoguchi, Takahiro Kato, Hideki Horikawa, Shigenobu Kanba
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33, 2, 308, 311, 17 Mar. 2009, [Peer-reviewed]
English, Scientific journal

[Study by young psychiatrists and significance and future challenge through their interactions--the scenes for learning and mutual support].
Uehara K, Kato T, Hashimoto N, Wake Y, Tanaka T, Baba T, Fujisawa D
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 111, 2, 221, 226, 2, Feb. 2009, [Peer-reviewed]

[A thought on postgraduate psychiatric education from the viewpoint of residents in the latter stage of training based on the system of training of psychiatric specialists--the latter part of the psychiatric training at university hospitals].
Nakano W, Kato T, Tateno M, Ikari K, Tanaka T, Nakamae T, Hojusan T, Nakamura J
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 111, 10, 1214, 1219, Jan. 2009, [Peer-reviewed]

Inhibitory effects of aripiprazole on interferon-gamma-induced microglial activation via intracellular Ca2+ regulation in vitro
Takahiro Kato, Yoshito Mizoguchi, Akira Monji, Hideki Horikawa, Satoshi O. Suzuki, Yoshihiro Seki, Toru Iwaki, Sadayuki Hashioka, Shigenobu Kanba
JOURNAL OF NEUROCHEMISTRY, 106, 2, 815, 825, Jul. 2008
English, Scientific journal

The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-gamma
Qian Bian, Takahiro Kato, Akira Monji, Sadayuki Hashioka, Yoshito Mizoguchi, Hideki Horikawa, Shigenobu Kanba
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 32, 1, 42, 48, Jan. 2008
English

Outcome assessment of clinical training of young physicians in psychiatry--from the results of a multi-center survey conducted by the Japanese Organization of Young Psychiatrists　　　　　　　　　　　　　　　
Reiko Sato, Takahiro Kato, Kimi Suenaga, Daisuke Fujisawa, Kumi Uehara
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 109, 11, 1072, 1081, Dec. 2007, [Peer-reviewed]
English

Current status and the issues involving young psychiatrists in the process of acquiring a professional status--a survey on the attitudes toward psychiatric training, psychiatric care and psychiatric medicine
Kato T, Hashimoto N, Sato R, Koizumi Y, Nakagawa A, Fujisawa D, Uehara K
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 109, 11, 1045, 1049, Dec. 2007, [Peer-reviewed]

Antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide
Sadayuki Hashioka, Andis Klegeris, Akira Monji, Takahiro Kato, Makoto Sawada, Patrick L. McGeer, Shigenobu Kanba
Experimental Neurology, 206, 1, 33, 42, Jul. 2007, [Peer-reviewed]
English, Scientific journal

Risperidone significantly inhibits interferon-gamma-induced microglial activation in vitro
Takahiro Kato, Akira Monji, Sadayuki Hashioka, Shigenobu Kanba
SCHIZOPHRENIA RESEARCH, 92, 1-3, 108, 115, May 2007
English, Scientific journal

Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation
Sadayuki Hashioka, Youn-Hee Han, Shunsuke Fujii, Takahiro Kato, Akira Monji, Hideo Utsumi, Makoto Sawada, Hiroshi Nakanishi, Shigenobu Kanba
FREE RADICAL BIOLOGY AND MEDICINE, 42, 7, 945, 954, Apr. 2007
English, Scientific journal

Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia
Sadayuki Hashioka, Youn-Hee Han, Shunsuke Fujii, Takahiro Kato, Akira Monji, Hideo Utsumi, Makoto Sawada, Hiroshi Nakanishi, Shigenobu Kanba
NEUROCHEMISTRY INTERNATIONAL, 50, 3, 499, 506, Feb. 2007
English, Scientific journal

Psychiatric training at university hospitals--a viewpoint of the first psychiatrists who were trained at the latter part of the new system
Miyajima K, Fujisawa D, Nakagawa A, Kato T
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 109, 11, 1039, 1044, 2007, [Peer-reviewed]

Interictal psychosis after stroke with forced normalization.
Ohara T, Monji A, Onitsuka T, Maekawa T, Hirano Y, Hirano S, Hashioka S, Kato T, Yoshida I, Kanba S
The Journal of neuropsychiatry and clinical neurosciences, 18, 4, 557, 559, Oct. 2006, [Peer-reviewed]

Different SPECT findings before and after Capgras' syndrome in interictal psychosis
Hideki Horikawa, Akira Monji, Masayuki Sasaki, Toshihiko Maekawa, Toshiaki Onitsuka, Yoko Nitazaka, Yoji Hirano, Shougo Hirano, Sadayuki Hashioka, Takahiro Kato, Ichiro Yoshida, Shigenobu Kanba
Epilepsy and Behavior, 9, 1, 189, 192, Aug. 2006, [Peer-reviewed]
English, Scientific journal

A question and answer E-mail system for responding to query from the general public with which the system manager can identify delayed replies
Takahiro Kato, Eisuke Hanada, Kyoko Takano, Yasuaki Antoku, Yoshiaki Nose
Journal of Medical Systems, 24, 1, 21, 28, Feb. 2000
English, Scientific journal

こころのフューチャー・デザイン:「未来人」からみた現代の精神医学 最終回 AIによる未来の「人間」消滅の危機――フューチャー・デザインで予防可能か？　　　　　　　　　　　　　　　
精神療法, 51, 6, 795, 800, Dec. 2025

こころのフューチャー・デザイン:「未来人」からみた現代の精神医学 第11回 ロボットによる未来のこころの医療現場 ドラえもんが精神科医になったら?　　　　　　　　　　　　　　　
加藤隆弘, 精神療法, 51, 5, 534, 539, Oct. 2025

【精神疾患における脳内炎症～新たな治療薬の可能性～】統合失調症におけるミクログリアを介した神経免疫仮説
久良木 聡太, 加藤 隆弘, ファルマシア, 61, 9, 832, 836, Sep. 2025
(公社)日本薬学会, Japanese

Introduction of Novel Psychiatry in the era of Hikikomori Pandemic (Part II) Experiencing the Happy Hikikomori Life through Future Design
加藤隆弘, 精神療法, 51, 4, 534, 539, Aug. 2025

Introduction of Novel Psychiatry in the Era of Hikikomori Pandemic: Considering the social pathology of ”Pathological Hikikomori” through past design
加藤隆弘, 精神療法, 51, 3, 384, 390, Jun. 2025

コミュニケーションロボットを用いたうつ病評価ツールの開発
松島敏夫, 吉川雄一郎, 熊崎博一, 加藤隆弘, 加藤隆弘, 精神科臨床Legato, 11, 1, 26, 31, Apr. 2025

生き延びるためのインターネット インターネットは「ひきこもり」を作る,あるいは,救う?
加藤隆弘, 精神医療, 17, 42, 48, Apr. 2025

ひきこもりの多面的理解と多面的支援　　　　　　　　　　　　　　　
加藤 隆弘, 医学のあゆみ, 293, 2, 132, 137, Apr. 2025

こころのフューチャーデザイン：「未来人」からみた現代の精神医学 第8回 行動経済学実験でこころのミクログリア仮説を証明する？こころを喪失した未来の無機質人間になって不合理な現代社会を展望する(Ⅱ)　　　　　　　　　　　　　　　
加藤 隆弘, 精神療法, 51, 2, 236, 241, Apr. 2025

社会的ひきこもりにおける現在および未来の就労支援　　　　　　　　　　　　　　　
加藤隆弘, 精神医学, 67, 3, 350, 358, Mar. 2025

Proving the Microglia Hypothesis of the Mind through Behavioral Economics Experiments?: Looking at the irrational modern society from the perspective of a mindless human of the future who has lost their mind in the 22nd century (Part I)
加藤隆弘, 精神療法, 51, 1, 98, 104, Feb. 2025

Integrated analysis of psychological stress and mental health blood biomarkers in students during the national examination preparation period
瀬戸山大樹, 福應温, 國崎祐哉, 國崎祐哉, 加藤隆弘, 日本薬学会年会要旨集(Web), 145th, 2025

社会的ひきこもりに対するVR・メタバースによる支援法の開発　　　　　　　　　　　　　　　
久保太聖, 加藤隆弘, 精神医学, 67, 1, 51, 59, Jan. 2025

発達障害 さまざまな対応 4 発達障害とひきこもり
黒田葉平, 黒田葉平, 加藤隆弘, 加藤隆弘, 精神科Resident, 5, 3, 223, 227, Dec. 2024

日本語臨床における「先生転移」－治療者が「先生逆転移」を自覚し取り扱うために－　　　　　　　　　　　　　　　
加藤隆弘, 精神療法, 50, 6, 845, 851, Dec. 2024

こころのフューチャーデザイン：「未来人」からみた現代の精神医学 第6回 フューチャー・デザインの方法③「今を疑う」逆説的思考：脳の中の火付け細胞ミクログリアと「死の欲動」　　　　　　　　　　　　　　　
加藤隆弘, 精神療法, 50, 6, 937, 942, Dec. 2024

うつ病の客観的血液指標を求めて メタボローム解析
康東天, 康東天, 瀬戸山大樹, 加藤隆弘, 検査と技術, 52, 11, 1124, 1126, Nov. 2024

こころのフューチャーデザイン：「未来人」からみた現代の精神医学 第5回 パストデザインで「心脳問題」を再考する 精神疾患は心の病気か？ 脳の病気か？　　　　　　　　　　　　　　　
加藤隆弘, 精神療法, 50, 5, 776, 780, Oct. 2024

Human monocyte‐derived microglia‐like (iMG) cells: A tool to explore microglial dynamics
Sota Kyuragi, Shogo Inamine, Masahiro Ohgidani, Takahiro A. Kato, Clinical and Experimental Neuroimmunology, 15, 4, 222, 227, 29 Sep. 2024
Abstract

Recent studies have highlighted the importance of microglia as key immunomodulators in a variety of neuropsychiatric diseases. Postmortem brain analysis and positron emission tomography are representative research approaches to assess microglial activation in human patients and this research has revealed microglial activation in the brains of patients with various neuropsychiatric disorders. However, only limited aspects of microglial activation can be assessed with these methods. To overcome the technical and ethical limitations of collecting human‐derived microglia in brain biopsies, we first developed a method to generate directly induced microglia‐like (iMG) cells from fresh human peripheral blood monocytes in 2014. These iMG cells can be used to perform dynamic morphological and molecular analyses regarding phagocytic capacity and cytokine release following stress stimulation at the cellular level. Patient‐derived iMG cells can potentially serve as an important surrogate marker for estimating microglial activation in the human brain, and may provide previously unknown insights into the dynamic pathophysiology of microglia in patients with neuropsychiatric disorders. Thus, the iMG‐based technology could be used as a valuable reverse translational tool and provide new insights into the dynamic molecular pathophysiology of microglia in a wide variety of psychiatric and physical disorders., Wiley

Engineering of Human Blood-Induced Microglia-like Cells for Reverse-Translational Brain Research
Sota Kyuragi, Shogo Inamine, Masahiro Ohgidani, Takahiro A. Kato, Journal of Visualized Experiments, 211, 06 Sep. 2024
MyJove Corporation

ひきこもりと流行-病的ひきこもりと非病的ひきこもり-　　　　　　　　　　　　　　　
舛田亮太, 加藤隆弘, 精神科治療学, 39, 9, 1037, 1042, Sep. 2024

Novel understandings of social withdrawal in youth: Introducing the concept of pathological and non-pathological hikikomori　　　　　　　　　　　　　　　
Kato TA, World Child & Adolescent Psychiatry, 26, 13, 39, Sep. 2024, [Peer-reviewed]

ダイナミズムとシンクロニシティ ひきこもりとデス・ドライブ（死の欲動）と精神分析　　　　　　　　　　　　　　　
加藤隆弘, 臨床心理学, 24, 5, 571, 577, Sep. 2024
Introduction scientific journal

精神分析と発達障害－「分かる」ではなく「分からない」世界を共に生きる精神分析的臨床－　　　　　　　　　　　　　　　
加藤隆弘, 精神療法, 50, 4, 510, 515, Aug. 2024
Introduction scientific journal

Method of Future Design (II) Becoming a Futurist: Perspectives on the boom of developmental disorders from the super-digital society of the 22nd century
加藤隆弘, 精神療法, 50, 4, 610, 615, Aug. 2024
Introduction scientific journal

【病態生理仮説が切り開くうつ病治療の未来】うつ病・自殺のミクログリア仮説 リバーストランスレーショナル研究による解明
加藤 隆弘, 臨床精神薬理, 27, 7, 673, 683, Jul. 2024
(株)星和書店, Japanese

うつ病の客観的血液指標を求めて　　　　　　　　　　　　　　　
康 東天, 加藤 隆弘, 瀬戸山 大樹, 日本臨床検査医学会誌, 72, 6, 476, 476, Jun. 2024
(一社)日本臨床検査医学会, Japanese

【神経系疾患における炎症と免疫】うつ病における炎症と免疫
久良木 聡太, 加藤 隆弘, 炎症と免疫, 32, 4, 294, 297, Jun. 2024
(株)先端医学社, Japanese

こころのフューチャー・デザイン 「未来人」からみた現代の精神医学(第3回) フューチャー・デザインの方法 過去にタイムスリップするパストデザイン　　　　　　　　　　　　　　　
加藤 隆弘, 精神療法, 50, 3, 438, 442, Jun. 2024
(株)金剛出版, Japanese

ヒト誘導ミクログリアが示す多様な免疫応答はミトコンドリア脆弱性に関連する　　　　　　　　　　　　　　　
米元 耕輔, 藤井 史彦, 平良 遼志, 扇谷 昌宏, 奥園 清香, チョン・ピンフィー, 吉良 龍太郎, 加藤 隆弘, 酒井 康成, 大賀 正一, 脳と発達, 56, Suppl., S228, S228, May 2024
(一社)日本小児神経学会, Japanese

うつ病におけるパーソナル・リカバリーを実現するための当事者を中心とした個別化医療の実現に向けて 精神病理学と生物学の融合によりうつ病を再構築する 未来の個別化医療の実現に向けて　　　　　　　　　　　　　　　
加藤 隆弘, 精神科Resident, 5, 1, 6, 7, Apr. 2024
(株)先端医学社, Japanese

アンヘドニアと精神病症状により抗癌剤治療拒否に至った30代女性の一例　　　　　　　　　　　　　　　
平方 秀典, 畑部 暢三, 大橋 綾子, 加藤 隆弘, 中尾 智博, 九州神経精神医学, 69, 2, 85, 86, Apr. 2024
九州精神神経学会, Japanese

【精神疾患と神経炎症】ヒト血液単球由来ミクログリア様細胞を用いたリバーストランスレーショナル研究　　　　　　　　　　　　　　　
久良木 聡太, 稲嶺 翔吾, 扇谷 昌宏, 加藤 隆弘, 臨床精神医学, 53, 4, 435, 442, Apr. 2024
(株)アークメディア, Japanese

こころのフューチャー・デザイン 「未来人」からみた現代の精神医学(第2回) 「楽観バイアス」を精神分析と経済学で考える　　　　　　　　　　　　　　　
加藤 隆弘, 精神療法, 50, 2, 274, 278, Apr. 2024
(株)金剛出版, Japanese

【よくわかる! 精神疾患対応 これ1冊-内科医と精神科医の連携のために】(第8部)知っておきたい最近の精神疾患関連トピックス ひきこもりの多面的理解とその対応
加藤 隆弘, 診断と治療, 112, Suppl., 331, 338, Mar. 2024
(株)診断と治療社, Japanese

Shifting the paradigm of social withdrawal: a new era of coexisting pathological and non-pathological hikikomori
Takahiro A. Kato, Norman Sartorius, Naotaka Shinfuku, Current Opinion in Psychiatry, 37, 3, 177, 184, 28 Feb. 2024
Purpose of review

Social withdrawal syndrome, known as “hikikomori,” has been highlighted since the late 1990 s in Japan. Hikikomori is more common in urban areas, and often comorbid with mental disorders, and now spreading throughout the world. In the post-COVID-19 era, not outing is no longer considered pathological in itself as the “new normal,” and a novel concept of hikikomori is needed. This review summarizes the concept of hikikomori, and presents the latest methods for identification of hikikomori.

Recent findings

The novel definition can distinguish between pathological and non-pathological hikikomori using the scale of “Hikikomori Diagnostic Evaluation (HiDE),” which has been developed in the hikikomori research lab at Kyushu University. An online survey among non-working adults has revealed that persons who have become pathological hikikomori for less than three months showed a particularly strong tendency toward gaming disorder and depression.

Summary

Now, physical isolation itself is not pathological, but when dysfunction and distress are present, rapid mental health support should be provided. In the novel urban society, the establishment of a checkup system to assess whether persons who stay home are happy or suffering is important for prevention against mental disorders triggered by social isolation., Ovid Technologies (Wolters Kluwer Health)

ひきこもりの現在の状況と今後の支援のあり方を検討する ひきこもり支援にコミュニケーションロボットやアバターは有用か?　　　　　　　　　　　　　　　
加藤 隆弘, 松島 敏夫, 吉川 雄一郎, 熊崎 博一, 日本社会精神医学会雑誌, 33, 1, 63, 69, Feb. 2024
(一社)日本社会精神医学会, Japanese

こころのフューチャー・デザイン 「未来人」からみた現代の精神医学(第1回) 「フューチャー・デザイン」とは? 経済学から精神医学を展望する　　　　　　　　　　　　　　　
加藤 隆弘, 精神療法, 50, 1, 102, 107, Feb. 2024
(株)金剛出版, Japanese

【精神疾患における環境要因と遺伝-環境相互作用】ひきこもりと精神疾患 従来の環境要因モデルから遺伝-環境相互作用モデルへ
加藤 隆弘, 医学のあゆみ, 288, 7, 555, 562, Feb. 2024
医歯薬出版(株), Japanese

【うつ病のバイオマーカー開発の試み】うつ病のメタボローム解析によるバイオマーカー開発の試み
松島 敏夫, 瀬戸山 大樹, 加藤 隆弘, 精神医学, 66, 2, 130, 136, Feb. 2024
(株)医学書院, Japanese

学校〇グループ～自殺～.　　　　　　　　　　　　　　　
梶本浩史, 加藤隆弘, 鎌田明日香, 菅武史, 那須里絵, 野村学, 廣瀨真理, 松尾真規子, 集団精神療法, 40, 2, 198, 200, 2024

Psychiatric Lecture 成因・危険因子 コロナ禍における会社員のひきこもりリスク因子に関する前向き調査
久保 浩明, 加藤 隆弘, 精神科臨床Legato, 9, 3, 143, 147, Dec. 2023
(株)メディカルレビュー社, Japanese

逃げたいこころの支援 うつ・発達障害・ひきこもりに寄り添うこと　　　　　　　　　　　　　　　
加藤 隆弘, 福岡県医報, 1570, 2, 8, Dec. 2023
(公社)福岡県医師会, Japanese

【オンライン・ICTメンタルヘルスサービスの発展と今後の展望】コミュニケーションロボットによるひきこもり・うつ病の早期支援
松島 敏夫, 吉川 雄一郎, 熊崎 博一, 加藤 隆弘, 精神障害とリハビリテーション, 27, 2, 165, 171, Nov. 2023
日本精神障害者リハビリテーション学会, Japanese

うつ病の客観的血液指標を求めて
康 東天, 加藤 隆弘, 瀬戸山 大樹, 日本臨床検査医学会誌, 71, 補冊, 011, 011, Oct. 2023
(一社)日本臨床検査医学会, Japanese

グリア多様性の理解に基づく精神・神経変性疾患の機序解明と治療法開発 ヒト血液由来直接誘導ミクログリア様(iMG)細胞を用いた精神神経疾患のリバーストランスレーショナル研究　　　　　　　　　　　　　　　
加藤 隆弘, 日本生化学会大会プログラム・講演要旨集, 96回, [1S12e, 02], Oct. 2023
(公社)日本生化学会, Japanese

血液メタボローム解析を用いたメンタルストレスを評価するための新たなバイオマーカーの探索　　　　　　　　　　　　　　　
福應 温, 瀬戸山 大樹, 松田 洋和, 加藤 隆弘, 康 東天, 國崎 祐哉, 日本生化学会大会プログラム・講演要旨集, 96回, [2P, 554], Oct. 2023
(公社)日本生化学会, Japanese

【適応障害(適応反応症)の予防と対策】"適応障害"と診断されがちな"新型/現代型うつ"の治療戦略 "逃げたいこころ"への共感と理解を促す心理社会的支援
加藤 隆弘, 医学のあゆみ, 287, 4, 253, 258, Oct. 2023
医歯薬出版(株), Japanese

新しいうつ病の病態仮説Beyond monoamines:創薬を見据えて 気分障害のミクログリア病態治療仮説 リバーストランスレーショナル研究　　　　　　　　　　　　　　　
加藤 隆弘, 日本神経精神薬理学会年会プログラム・抄録集, 53回, 76, 76, Sep. 2023
(一社)日本神経精神薬理学会, Japanese

ひきこもりの意思決定の基礎・臨床・理論によるトランスレーショナルリサーチ 社会的ひきこもりの精神医学的位置付けとその生物学的病態解明　　　　　　　　　　　　　　　
加藤 隆弘, 日本神経精神薬理学会年会プログラム・抄録集, 53回, 97, 97, Sep. 2023
(一社)日本神経精神薬理学会, Japanese

多様な疾患における疼痛過敏化および疼痛遷延化の基礎的・臨床的多次元解析と次世代型薬物治療 複合性疼痛病態の解明を目指したiPS細胞ならびにiMG細胞由来分化細胞の解析と治療標的探索　　　　　　　　　　　　　　　
葛巻 直子, 須田 雪明, 濱田 祐輔, 加藤 隆弘, 細井 昌子, 石川 充, 岡野 栄之, 成田 年, 日本神経精神薬理学会年会プログラム・抄録集, 53回, 109, 109, Sep. 2023
(一社)日本神経精神薬理学会, Japanese

データ駆動進化医学で解く季節性うつと冬眠の代謝基盤　　　　　　　　　　　　　　　
柚木克之, 加藤隆弘, 科学, 93, 9, 791, 795, Sep. 2023

視覚刺激を用いた疾患教育が有効だった身体症状症の一例　　　　　　　　　　　　　　　
廣田 眞央, 畑部 暢三, 中澤 太郎, 小原 知之, 平野 羊嗣, 加藤 隆弘, 中尾 智博, 九州神経精神医学, 68, 3-4, 119, 119, Aug. 2023
九州精神神経学会, Japanese

ひきこもり事例の訪問支援における支援者要因の検討 宮崎県内の支援者を対象としたインタビュー調査　　　　　　　　　　　　　　　
久保 浩明, 直野 慶子, 境 泉洋, 船橋 英樹, 加藤 隆弘, 石田 康, 九州神経精神医学, 68, 3-4, 130, 130, Aug. 2023
九州精神神経学会, Japanese

西園昌久先生を偲ぶ－「日韓両国の若い精神科医のための合同研修会」での想い出－　　　　　　　　　　　　　　　
加藤隆弘, こころと文化, 22, 1, 110, 112, Aug. 2023

精神療法と治癒像 フロイト精神分析における治癒像 「死の欲動」を抱えること　　　　　　　　　　　　　　　
加藤 隆弘, 精神神経学雑誌, 2023特別号, S321, S321, Jun. 2023
(公社)日本精神神経学会, Japanese

精神疾患におけるヒューマノイドロボットを用いた支援の現状と今後の課題 ひきこもり早期支援のためのコミュニケーションロボットによる診断評価法の開発　　　　　　　　　　　　　　　
加藤 隆弘, 精神神経学雑誌, 2023特別号, S338, S338, Jun. 2023
(公社)日本精神神経学会, Japanese

いまなぜグループか? 新しいつながり時代の集団精神療法 ひきこもりと集団精神療法母校的居場所の中で「ひきこもる能力」を獲得すること　　　　　　　　　　　　　　　
加藤 隆弘, 精神神経学雑誌, 2023特別号, S490, S490, Jun. 2023
(公社)日本精神神経学会, Japanese

ゲーム障害の予防・治療について 社会的ひきこもりとゲーム障害における鶏卵問題とその打開策の提案　　　　　　　　　　　　　　　
加藤 隆弘, 精神神経学雑誌, 2023特別号, S628, S628, Jun. 2023
(公社)日本精神神経学会, Japanese

炎症免疫細胞ミクログリアから考える臨床ストレス科学 痛みからうつ病まで　　　　　　　　　　　　　　　
加藤 隆弘, 日本心身医学会総会ならびに学術講演会プログラム・抄録集, 64回, 66, 66, Jun. 2023
日本心身医学会総会ならびに学術講演会事務局, Japanese

ナルシズムの脳科学－フロイトの『死の欲動』の生物学的起源とその現代的意義　　　　　　　　　　　　　　　
加藤隆弘, 思春期青年期精神医学, 33, 1, 17, 27, Jun. 2023

「第一回土居健郎精神分析奨励賞」受賞に際して—日本人による日本人のための精神分析を耕して輸出すること—　　　　　　　　　　　　　　　
加藤隆弘, 日本精神分析協会年報, 13, 24, 25, Jun. 2023

ひきこもりの集団精神療法－沈黙の中で「ひきこもる能力」を獲得し卒業すること　　　　　　　　　　　　　　　
加藤隆弘, 精神療法 増刊第10号, 174, 182, Jun. 2023

慢性疼痛 慢性疼痛と新型/現代型うつ　　　　　　　　　　　　　　　
加藤 隆弘, 藤本 晃嗣, 細井 昌子, 精神神経学雑誌, 62, 2023特別号, S348, S348, Jun. 2023
(公社)日本精神神経学会, Japanese

ヒト誘導ミクログリアを用いた炎症性シグナルの解析
米元 耕輔, 藤井 史彦, 平良 遼志, 扇谷 昌宏, 奥園 清香, チョン・ピンフィー, 吉良 龍太郎, 加藤 隆弘, 酒井 康成, 大賀 正一, 脳と発達, 55, Suppl., S297, S297, May 2023
(一社)日本小児神経学会, Japanese

ひきこもりの多面的理解：文化社会モデルから最新医学・心理学・生物学の融合モデルへ　　　　　　　　　　　　　　　
加藤隆弘, メディカル・サイエンス・ダイジェスト, 49, 3, 105, 109, Mar. 2023

西園昌久先生を偲ぶ－Nishizonoismに触れ得たことへの感謝－　　　　　　　　　　　　　　　
加藤隆弘, 精神分析研究, 67, 1, 61, 63, Feb. 2023

うつ病におけるパーソナルリカバリーを実現するための当事者を中心とした個別化医療の実現に向けて 精神病理学と生物学の融合によりうつ病を再構築する 未来の個別化医療の実現に向けて
加藤 隆弘, ストレス科学, 38, 1, 273, 273, 2023
日本ストレス学会, Japanese

一見軽症に見える治療抵抗性のうつ：現代抑うつ症候群の理解と治療戦略　　　　　　　　　　　　　　　
松島敏夫, 加藤隆弘, 精神科, 42, 1, 106, 115, Jan. 2023

西園昌久先生を偲ぶ－孫世代を代表して－　　　　　　　　　　　　　　　
加藤隆弘, 思春期青年期精神医学, 32, 2, 155, 158, Dec. 2022

ひきこもり支援にグループの視点を活用する―MHFAとCRAFTを応用したひきこもる個人と集団の橋渡し―　　　　　　　　　　　　　　　
加藤隆弘, 境泉洋, 久保浩明, 集団精神療法, 38, 2, 204, 206, Dec. 2022

Editorial: The development of biomarkers in psychiatry
Takashi Nakano, Masahiro Takamura, Takahiro A. Kato, Shin-ichi Kano, Frontiers in Psychiatry, 13, 01 Dec. 2022
Frontiers Media SA

COVID-19時代の新たなひきこもり－社会的ひきこもりを量産しないために－　　　　　　　　　　　　　　　
加藤隆弘, 精神医学, 64, 11, 1487, 1499, Nov. 2022

自殺とひきこもりを考える：精神分析の「死の欲動」と脳内免疫細胞ミクログリアとの接点から　　　　　　　　　　　　　　　
加藤隆弘, 精神科治療学, 37, 11, 1241, 1246, Nov. 2022

日光不足による季節性感情障害　　　　　　　　　　　　　　　
松島敏夫, 加藤隆弘, 保健の科学, 64, 10, 681, 686, Oct. 2022

気分障害をターゲットとしたメタボローム解析研究—九州大学病院でのトライアル　　　　　　　　　　　　　　　
松島敏夫, 瀬戸山大樹, 加藤隆弘, 臨床精神医学, 51, 10, 1121, 1129, Oct. 2022

ヒト末梢血誘導型ミクログリア細胞技術を用いた慢性疼痛研究　　　　　　　　　　　　　　　
扇谷昌宏, 加藤隆弘, 細井昌子, 心身医学, 62, 5, 390, 393, Sep. 2022

ひきこもる能力を育む－精神分析の立場からコロナ時代のひきこもり支援を考える　　　　　　　　　　　　　　　
加藤隆弘, 精神療法, 増刊, 9, 104, 112, Jun. 2022

精神分析のエッセンス：無意識のシナリオ理解に基づく精神科臨床への活用　　　　　　　　　　　　　　　
加藤隆弘, 九州神経精神医学, 67, 2, 35, 42, Apr. 2022

ひきこもりの多面的な理解と支援～家族支援から本人支援に繋ぐコツ～　　　　　　　　　　　　　　　
加藤隆弘, ふくおか精神保健, 67, 16, 38, Mar. 2022

コロナ禍における社会的ひきこもりの早期支援のためのアセスメント　　　　　　　　　　　　　　　
加藤隆弘, ふくおか精神保健, 67, 47, 52, Mar. 2022

【特集: COVID-19を超えて-これからの精神医学をめぐる環境】コロナ禍から考えるひきこもり臨床の現在と未来　　　　　　　　　　　　　　　
加藤 隆弘, 臨床精神医学, 51, 3, 287, 294, Mar. 2022
Introduction scientific journal

「エヴィデンスを考える集い」を終えて－解釈という精神分析のエヴィデンス－　　　　　　　　　　　　　　　
精神分析研究, 66, 1, 32, 33, Feb. 2022
Report scientific journal

木村宏之先生のご討論に対するレスポンス　　　　　　　　　　　　　　　
加藤隆弘, 精神分析研究, 66, 1, 25, 28, Feb. 2022
Introduction scientific journal

日本の精神分析の未来－エヴィデンス神話をエディプス神話から読み解く－　　　　　　　　　　　　　　　
加藤 隆弘, 精神分析研究, 66, 1, 9, 21, Feb. 2022
Report scientific journal

ひきこもりとグループと精神療法－「集団の中でひきこもる能力」を獲得すること－　　　　　　　　　　　　　　　
加藤 隆弘, 集団精神療法, 37, 2, Dec. 2021

フロイトが創出した精神分析：自由と不自由が共存する時空間で獲得するこころの自由　　　　　　　　　　　　　　　
加藤隆弘, 最新精神医学, 26, 6, 479, 485, Nov. 2021

統合失調症の神経活動異常と神経免疫異常　　　　　　　　　　　　　　　
平野 羊嗣, 加藤 隆弘, 生体の科学, 72, 5, 434, 437, Oct. 2021

ミクログリアによる社会的意思決定の制御－ミクログリアは無意識由来行動をつかさどる？　　　　　　　　　　　　　　　
加藤隆弘, 生体の科学, 72, 5, 442, 445, Oct. 2021

臨床に役立つ基礎薬理学の用語解説(第23回) メタボロミクス　　　　　　　　　　　　　　　
瀬戸山 大樹, 加藤 隆弘, 臨床精神薬理, 24, 9, 966, 967, Sep. 2021

精神分析と脳科学から紡ぎ出されるこころの科学－サイコグリアアナリシスへの誘い.　　　　　　　　　　　　　　　
加藤 隆弘, こころの科学, 219, 122, 128, Sep. 2021

ひきこもり支援の道標として『治療的な接近を模索して』（小倉清著1993）を読む　　　　　　　　　　　　　　　
加藤隆弘, 思春期青年期精神医学, 31, 1, 9, 15, Aug. 2021

ひきこもりの相談を受けたら：社会的ひきこもりの多面的理解に基づくより良い支援　　　　　　　　　　　　　　　
加藤 隆弘, 福岡行動医学雑誌, 27, 1, 49, 55, Jul. 2021

Facing and treating hikikomori (pathological social withdrawal)　　　　　　　　　　　　　　　
Kato TA, Quaderni Di Psicoterapia Cognitiva, 48, 11, 19, Jul. 2021

ヒト血液を用いた脳内ミクログリア活動性予測による心のリバース・トランスレーショナル研究　　　　　　　　　　　　　　　
加藤隆弘, 連載「ミクログリア研究の最前線-基礎から臨床へ」第5回, 和光純薬時報, 89, 3, 21, 22, Jul. 2021

「死の欲動」の彼岸.「精神分析と脳科学が出会ったら？」　　　　　　　　　　　　　　　
加藤隆弘, こころの科学, 218, 116, 123, Jul. 2021

メタボローム解析からみたストレスの指標　　　　　　　　　　　　　　　
松島 敏夫, 瀬戸山 大樹, 加藤 隆弘, Clinical Neuroscience, 39, 6, 701, 705, Jun. 2021

自殺未遂者へのケア－救急から地域までの包括的支援－　　　　　　　　　　　　　　　
大塚 耕太郎, 加藤 隆弘, 小原 圭司, 赤平 美津子, 保健の科学, 63, 6, 396, 400, Jun. 2021

ヒト血液を用いた精神疾患ミクログリア仮説解明のための橋渡し研究　　　　　　　　　　　　　　　
加藤 隆弘, 扇谷 昌宏, 瀬戸山 大樹, 久保 浩明, 渡部 幹, 康 東天, 神庭 重信, 日本生物学的精神医学会誌, 32, 1, 18, 25, May 2021

「死の欲動」の生物学的起源－自殺・うつ病のミクログリア仮説.「精神分析と脳科学が出会ったら？」　　　　　　　　　　　　　　　
加藤隆弘, こころの科学, 217, May 2021

ヒト血液由来直接誘導ミクログリア様 (iMG)細胞の開発とリバーストランスレーショナル研究への応用　　　　　　　　　　　　　　　
加藤隆弘, 稲嶺翔吾, 扇谷昌宏, Medical Science Digest, 47, 4, Apr. 2021

コロナ禍におけるメンタルヘルス・ファーストエイド　　　　　　　　　　　　　　　
加藤隆弘, 浦田裕美, 小原圭司, 地方公務員 安全と健康フォーラム, 117, Apr. 2021

フロイトによる性欲論の展開－欲動の源泉「生ける小胞」とミクログリア　　　　　　　　　　　　　　　
加藤隆弘, こころの科学, 216, Mar. 2021

Involvement of microglia in disturbed fear memory regulation: Possible microglial contribution to the pathophysiology of posttraumatic stress disorder
Shingo Enomoto, Takahiro A. Kato, Neurochemistry International, 142, 104921, 104921, Jan. 2021, [Peer-reviewed]
Elsevier BV

地域全体での取り組み・プログラム開発や効果検証　　　　　　　　　　　　　　　
小原圭司, 浦田裕美, 加藤 隆弘, 安全と健康フォーラム, 116, Jan. 2021

反復強迫とミクログリアの活性化：エディプスコンプレックス・阿闍世コンプレックスの脳科学モデル　　　　　　　　　　　　　　　
加藤 隆弘, こころの科学, 215, Jan. 2021

診断バイオマーカーうつ病の血液バイオマーカー開発の試み—　　　　　　　　　　　　　　　
瀬戸山大樹, 加藤隆弘, 精神科, 37, 6, Dec. 2020

ひきこもりの生物学的基盤 ひきこもりにバイオマーカーは存在するのか?　　　　　　　　　　　　　　　
早川 宏平, 加藤 隆弘, 臨床心理学, 20, 6, Nov. 2020

新しい「社会的ひきこもり」の評価法：コロナ禍での地域における活用の提案　　　　　　　　　　　　　　　
加藤隆弘, 地域ケアリング, 22, 12, Nov. 2020

無意識を測るメソッドと出会う旅：ミクログリアは信頼行動にノイズを引き起こす？　　　　　　　　　　　　　　　
加藤 隆弘, こころの科学, Nov. 2020

アルコール・薬物などへの依存の問題に対するメンタルヘルス・ファーストエイド　　　　　　　　　　　　　　　
長 徹二, 加藤 隆弘, 浦田 裕美, 地方公務員 安全と健康フォーラム, Oct. 2020

精神疾患ミクログリア仮説からみた双極性障害とその橋渡し研究　　　　　　　　　　　　　　　
加藤 隆弘, 扇谷 昌宏, 神庭 重信, 日本臨牀, Oct. 2020
日本臨牀, Japanese

精神分析と脳内免疫細胞ミクログリアとの出会い：統合失調症の水治療仮説　　　　　　　　　　　　　　　
加藤 隆弘, こころの科学, Sep. 2020
「こころの科学」No.213【連載「精神分析と脳科学が出会ったら？」第6回】, Japanese

ひきこもりの精神分析的グループ精神療法：突然の就労に至ったケースを振り返る　　　　　　　　　　　　　　　
加藤 隆弘, 久保浩明, 九州神経精神医学, 66, 2, 66, 71, Aug. 2020

「科学的心理学草稿」におけるこころの神経モデル　　　　　　　　　　　　　　　
加藤 隆弘, こころの科学, Jul. 2020
「こころの科学」No.212【連載「精神分析と脳科学が出会ったら？」第5回】, Japanese

精神疾患におけるミクログリア活性化制御をターゲットとした創薬への期待　　　　　　　　　　　　　　　
加藤 隆弘, 老年精神医学雑誌, Jul. 2020
老年精神医学雑誌, Japanese

セルフヘルプやその他のサポートを勧めましょう　　　　　　　　　　　　　　　
加藤 隆弘, 浦田 裕美, 地方公務員 安全と健康フォーラム, Jul. 2020
地方公務員 安全と健康フォーラム 第114号:【連載-第5回「こころの応急処置メンタルヘルス・ファーストエイド」】, Japanese

書評「ひきこもり問題を講義する－専門職の相談支援技術を高めるために」(近藤 直司著 岩崎学術出版社 2019年12月)　　　　　　　　　　　　　　　
加藤隆弘, 精神療法, Jun. 2020
精神療法, Japanese

Digital transformation and the socially reclusive: A study of ICT and the hikikomori in Japan　　　　　　　　　　　　　　　
Tan F.T.C, Kato TA, Ondrus J, Tan B, 24th Pacific Asia Conference on Information Systems: Information Systems (IS) for the Future, PACIS 2020 (Conference Paper), Jun. 2020
24th Pacific Asia Conference on Information Systems: Information Systems (IS) for the Future, PACIS 2020 (Conference Paper), English

精神分析と母子分離 最早期トラウマの脳内基盤をモデル動物で検証可能か　　　　　　　　　　　　　　　
加藤 隆弘, こころの科学, May 2020
「こころの科学」No.211【連載「精神分析と脳科学が出会ったら？」第4回】, Japanese

安心につながる支援と情報を提供し、専門家のサポートを勧めましょう　　　　　　　　　　　　　　　
加藤 隆弘, 浦田 裕美, 地方公務員 安全と健康フォーラム, Apr. 2020
地方公務員 安全と健康フォーラム 第113号:【連載-第4回「こころの応急処置メンタルヘルス・ファーストエイド」】, Japanese

脳神経学者フロイトをこころの探究者へ導いたヒステリー　　　　　　　　　　　　　　　
加藤 隆弘, こころの科学, Mar. 2020
「こころの科学」No.210【連載「精神分析と脳科学が出会ったら？」第3回】, Japanese

脳内免疫細胞ミクログリアに着目した精神疾患のトランスレーショナル研究　　　　　　　　　　　　　　　
加藤 隆弘, 日本生物学的精神医学会誌, Mar. 2020
日本生物学的精神医学会誌, Japanese

現代社会における抑うつ症候群としての新型/現代型うつ　　　　　　　　　　　　　　　
加藤 隆弘, 香月 亮子, 臨床精神医学, Feb. 2020
臨床精神医学, Japanese

決めつけず、批判せずにはなしを聞き、コミュニケーションをとりましょう.　　　　　　　　　　　　　　　
加藤 隆弘, 浦田 裕美, 地方公務員 安全と健康フォーラム, Jan. 2020
地方公務員 安全と健康フォーラム 第112号:【連載-第3回「こころの応急処置メンタルヘルス・ファーストエイド」】, Japanese

現代の多層化・複雑化した脳科学研究と精神分析の居場所　　　　　　　　　　　　　　　
加藤 隆弘, こころの科学, Jan. 2020
「こころの科学」No.209【連載「精神分析と脳科学が出会ったら？」第2回】, Japanese

ひきこもりの多面的理解と治療アプローチ：ロボット治療への期待　　　　　　　　　　　　　　　
加藤 隆弘, 総合病院精神医学, Jan. 2020
総合病院精神医学, Japanese

うつ病・自殺のミクログリア仮説と解明のための橋渡し研究　　　　　　　　　　　　　　　
加藤 隆弘, 福岡医学雑誌, Dec. 2019
福岡医学雑誌, Japanese

ひきこもりの多軸的評価とバイオマーカー　　　　　　　　　　　　　　　
加藤隆弘, 早川 宏平, 精神科臨床Legato, Nov. 2019
精神科臨床Legato, Japanese

脳とこころが交差する悩ましい世界への旅　　　　　　　　　　　　　　　
加藤隆弘, こころの科学, Oct. 2019
こころの科学:連載「精神分析と脳科学が出会ったら？」第１回, Japanese

うつかな？と思ったら、声をかけ、リスクを評価しましょう.　　　　　　　　　　　　　　　
加藤隆弘, 浦田裕美, 地方公務員 安全と健康フォーラム, Oct. 2019
地方公務員 安全と健康フォーラム:連載「こころの応急処置メンタルヘルス・ファーストエイド」第2回, Japanese

働くミクログリアとその破綻としての精神疾患　　　　　　　　　　　　　　　
加藤隆弘, 精神科, Oct. 2019
精神科, Japanese

訳『精神力動的精神医学 第5版』第12章：27－60, 第13章：317-329, (ギャバード著 ）　　　　　　　　　　　　　　　
加藤隆弘, 岩崎学術出版社, Oct. 2019
岩崎学術出版社, Japanese

気分障害のミクログリア仮説　　　　　　　　　　　　　　　
加藤隆弘, 精神科治療学, Sep. 2019
精神科治療学, Japanese

こころの不調のイエローサインと最初の「声かけ」　　　　　　　　　　　　　　　
加藤隆弘, 浦田裕美, 地方公務員 安全と健康フォーラム, Jul. 2019
地方公務員 安全と健康フォーラム:連載「こころの応急処置メンタルヘルス・ファーストエイド」第1回, Japanese

『私の研究紹介』心のミクログリア仮説解明を志して　　　　　　　　　　　　　　　
加藤隆弘, 分子精神医学, Jul. 2019
分子精神医学, Japanese

周産期メンタルヘルスの初期対応に役立つ! "メンタルヘルス・ファーストエイド"の活用【前編】うつ病への初期対応法　　　　　　　　　　　　　　　
浦田裕美, 加藤隆弘, 臨床助産ケア, Jul. 2019
臨床助産ケア, Japanese

ひきこもり 文化横断的討論 引きこもりへの多元的アプローチ　　　　　　　　　　　　　　　
加藤隆弘, 思春期青年期精神医学, Jun. 2019
春期青年期精神医学, Japanese

"精神神経科領域におけるロボット治療の現状と今後の課題 ひきこもり治療にロボットをどう活かすか? ドラえもんがのび太を救う."　　　　　　　　　　　　　　　
加藤 隆弘, 精神神経学雑誌(2019特別号), Jun. 2019
精神神経学雑誌(2019特別号), Japanese

『ひきこもり』者の回避性パーソナリティ特性と血中バイオマーカー　　　　　　　　　　　　　　　
早川 平宏, 加藤 隆弘, 渡部 幹, テオ・アラン, 堀川 英喜, 桑野 信貴, 下川憲宏, 佐藤 美那, 久保 浩明, 扇谷 昌宏, 佐方 功明, 戸田 裕之, 館農 勝, 新福 尚隆, 岸本 淳司, 神庭 重信, 精神神経学雑誌(2019特別号), Jun. 2019
精神神経学雑誌(2019特別号), Japanese

"ミクログリアは精神疾患の成り立ちにどのように関与するのか? ミクログリアと心 脳内免疫細胞が心理社会的活動とその破綻に関わる可能性."　　　　　　　　　　　　　　　
加藤 隆弘, 精神神経学雑誌(2019特別号), Jun. 2019
精神神経学雑誌(2019特別号), Japanese

書評:青年のひきこもり・その後―包括的アセスメントと支援の方法論 (近藤 直司 著 岩崎学術出版社2017年11月)　　　　　　　　　　　　　　　
加藤隆弘, 精神分析研究, May 2019
精神分析研究, Japanese

【自殺を予測し防ぐ】 血液メタボローム解析で抑うつ重症度・自殺念慮を客観的に評価する試み　　　　　　　　　　　　　　　
加藤 隆弘, 瀬戸山 大樹, 桑野 信貴, 康 東天, 神庭 重信, 精神科, 34, 5, 515, 523, May 2019
(有)科学評論社, Japanese

Hikikomori : Multidimensional understanding, assessment, and future international perspectives.
Kato TA, Kanba S, Teo AR, Psychiatry and clinical neurosciences, May 2019, [Peer-reviewed]

絶対臥褥からはじまる古典的森田療法と週4回カウチによる古典的精神分析：「あるがまま」の境地にいたる二つの道　　　　　　　　　　　　　　　
加藤 隆弘, 日本森田療法学会雑誌, Apr. 2019
日本森田療法学会雑誌, Japanese

【不登校・ひきこもりに対する精神科医療の関わり】 ひきこもりの家族への相談・支援　　　　　　　　　　　　　　　
久保 浩明, 加藤 隆弘, 精神科治療学, 34, 4, 423, 428, Apr. 2019
(株)星和書店, Japanese

"変わりゆくグリア細胞の役割 ミクログリア目線で疾患を診る! ヒト血液由来ミクログリア様(iMG)細胞を用いた精神疾患トランスレーショナル研究."　　　　　　　　　　　　　　　
加藤 隆弘, 扇谷 昌宏, 神庭 重信, 日本薬学会年会要旨集 139年会, Mar. 2019
日本薬学会年会要旨集 139年会, Japanese

"第3回臨床化学の進歩が変える薬物治療 臨床検査と薬学の融合 メタボローム解析によるうつ病のバイオマーカー探索."　　　　　　　　　　　　　　　
康 東天, 瀬戸山 大樹, 加藤 隆弘, 神庭 重信, 日本薬学会年会要旨集 139年会, Mar. 2019
日本薬学会年会要旨集 139年会, Japanese

【ひきこもりの研究】 ひきこもりのバイオマーカー　　　　　　　　　　　　　　　
早川 宏平, 加藤 隆弘, 精神科, 34, 2, 164, 171, Feb. 2019
(有)科学評論社, Japanese

精神疾患の新しいモデルーミクログリア仮説　　　　　　　　　　　　　　　
加藤隆弘, 神庭重信, 日経サイエンス, Jan. 2019
日経サイエンス, Japanese

服薬と処方の心理 くすりを飲む心理・出す心理 転移-逆転移を扱う 精神分析の立場から処方行動を考える　　　　　　　　　　　　　　　
加藤 隆弘, こころの科学, 203, 33, 39, Jan. 2019
(株)日本評論社, Japanese

【うつ病における炎症・酸化ストレスの役割と創薬への発展性】 ミクログリア仮説に鑑みた気分障害の血液バイオマーカー研究　　　　　　　　　　　　　　　
加藤 隆弘, 扇谷 昌宏, 桑野 信貴, 瀬戸山 大樹, 康 東天, 神庭 重信, 日本生物学的精神医学会誌, 29, 4, 182, 188, Dec. 2018
日本生物学的精神医学会, Japanese

【線維筋痛症-最新の基礎・臨床知見-】 線維筋痛症の基礎・臨床研究 線維筋痛症のトランスレーショナル研究 ミクログリア過剰活性化とTNF-α　　　　　　　　　　　　　　　
扇谷 昌宏, 細井 昌子, 加藤 隆弘, 日本臨床, 76, 11, 1937, 1942, Nov. 2018
(株)日本臨床社, Japanese

精神分析と脳科学から「死の欲動」を考える 人はなぜ戦争そして自殺をするのか　　　　　　　　　　　　　　　
加藤 隆弘, 心と社会, 49, 3, 50, 59, Sep. 2018
(公財)日本精神衛生会, Japanese

精神疾患研究におけるブレイクスルー〜グリア細胞の重要性〜 ヒト末梢血単球由来の直接誘導ミクログリア様(iMG)細胞を用いた精神疾患トランスレーショナル研究　　　　　　　　　　　　　　　
加藤 隆弘, 扇谷 昌宏, 神庭 重信, 精神神経学雑誌, 2018特別号, S631, S631, Jun. 2018
(公社)日本精神神経学会, Japanese

日本人研究者が発信したオリジナルな統合失調症病態仮説を統合する 統合失調症におけるミクログリア仮説　　　　　　　　　　　　　　　
加藤 隆弘, 精神神経学雑誌, 2018特別号, S470, S470, Jun. 2018
(公社)日本精神神経学会, Japanese

次世代の精神疾患の診断・客観的症状評価法の開発 血液メタボローム解析による気分障害の客観的バイオマーカー開発 採血で抑うつや自殺念慮の予測は可能か?　　　　　　　　　　　　　　　
加藤 隆弘, 精神神経学雑誌, 2018特別号, S274, S274, Jun. 2018
(公社)日本精神神経学会, Japanese

血液メタボローム解析による、抑うつ重症度・希死念慮のバイオマーカー開発研究　　　　　　　　　　　　　　　
加藤 隆弘, 先進医薬研究振興財団研究成果報告集, 2017年度, 28, 29, Mar. 2018
(公財)先進医薬研究振興財団, Japanese

【グローバリゼーションと臨床精神医学】 グローバリゼーションと社会的ひきこもり ひきこもりは現代社会結合症候群か?　　　　　　　　　　　　　　　
加藤 隆弘, 臨床精神医学, 47, 2, 137, 145, Feb. 2018
(株)アークメディア, Japanese

【ストレス関連疾患のメカニズム-最近の知見から】 精神疾患における炎症性サイトカインを介したミクログリア病態治療仮説　　　　　　　　　　　　　　　
加藤 隆弘, 神庭 重信, 日本医事新報, 4895, 36, 42, Feb. 2018
(株)日本医事新報社, Japanese

第19回 日韓若手精神科医による合同研修会報告
鈴木 宗幸, 権 淳嗣, 堀之内 徹, 長 徹二, 田中 増郎, 猪狩 圭介, 藤本 美智子, 加藤 隆弘, 九州神経精神医学, 64, 2, 77, 85, 2018
九州精神神経学会, Japanese

【Research Domain Criteria(RDoC)プロジェクトの目指す新たな精神医学診断・評価システム】 末梢血バイオマーカーを用いた精神医学評価システムの構築 現代のうつ病診断・評価における困難の打開に向けて
加藤 隆弘, 精神医学, 60, 1, 51, 62, Jan. 2018
(株)医学書院, Japanese

RDoC(Research Domain Criteria)によりうつ病研究はどうなりますか　　　　　　　　　　　　　　　
橋本 亮太, 加藤 隆弘, Depression Journal, 5, 3, 96, 97, Dec. 2017
(株)メディカルレビュー社, Japanese

Translational Research Using Human Blood Directly Induced Microglia-Like (iMG) Cells; Over Gene Expression and Production of TNF-alpha After ATP Stimulation in iMG Cells from Patients with Fibromyalgia
Takahiro Kato, Masahiro Ohgidani, Masako Hosoi, Shigenobu Kanba, NEUROPSYCHOPHARMACOLOGY, 43, S619, S619, Nov. 2017
English, Summary international conference

第2回対談「先達に聞く」現代の精神医学へのヒント　　　　　　　　　　　　　　　
西園 昌久, 加藤 隆弘, 分子精神医学, Oct. 2017
分子精神医学, Japanese

【精神医学症候群(第2版)[III]-物質関連障害および嗜癖性障害群からてんかんまで-】 パーソナリティ障害群 B群パーソナリティ障害 演技性パーソナリティ障害　　　　　　　　　　　　　　　
久保 浩明, 加藤 隆弘, 日本臨床, 別冊, 精神医学症候群III, 271, 275, Sep. 2017
(株)日本臨床社, Japanese

【モチベーションの科学】 社会的ひきこもり・現代抑うつ症候群に対するモチベーション障害評価システムの構築　　　　　　　　　　　　　　　
加藤 隆弘, 神庭 重信, 最新精神医学, 22, 5, 383, 389, Sep. 2017
(株)世論時報社, Japanese

【ミクログリアと精神・神経疾患】 精神疾患のミクログリア病態治療仮説 橋渡し研究による仮説解明をめざして　　　　　　　　　　　　　　　
加藤 隆弘, 扇谷 昌宏, 神庭 重信, BRAIN and NERVE: 神経研究の進歩, 69, 9, 1007, 1015, Sep. 2017
(株)医学書院, Japanese

【向精神薬の多剤規制と減量・離脱の実際】 アジアの向精神薬処方動向から見た日本の薬物療法の課題　　　　　　　　　　　　　　　
新福 尚隆, 早川 宏平, Lin Shih-Ku, 加藤 隆弘, 臨床精神薬理, 20, 9, 983, 991, Sep. 2017
(株)星和書店, Japanese

「現代抑うつ症候群(新型うつ・現代うつ)」は閾値下うつ、あるいは、適応障害か? 精神医学的知見に鑑みて　　　　　　　　　　　　　　　
加藤 隆弘, 桑野 信貴, 神庭 重信, ストレス科学, 32, 1, 63, 73, Aug. 2017
日本ストレス学会, Japanese

精神疾患のバイオマーカー (巻頭言)　　　　　　　　　　　　　　　
加藤 隆弘, 分子精神医学, Jul. 2017
分子精神医学, Japanese

【精神疾患のバイオマーカー】 血液メタボローム解析による、うつ重症度・自殺念慮のバイオマーカー開発　　　　　　　　　　　　　　　
加藤 隆弘, 瀬戸山 大樹, 橋本 亮太, 功刀 浩, 服部 功太郎, 康 東天, 神庭 重信, 分子精神医学, 17, 3, 199, 205, Jul. 2017
(株)先端医学社, Japanese

【心理専門職も知っておきたい精神医学・医療の現在】 脳科学と精神分析の架橋　　　　　　　　　　　　　　　
加藤 隆弘, 臨床心理学, 17, 3, 350, 351, May 2017
(株)金剛出版, Japanese

Editorial: Minding Glial Cells in the Novel Understandings of Mental Illness
Takahiro A. Kato, Aye M. Myint, Johann Steiner, FRONTIERS IN CELLULAR NEUROSCIENCE, 11, 48, Feb. 2017, [Peer-reviewed]
English, Others

精神科研修医における燃え尽き症候群についての国際共同研究(BoSS International) 日本国内調査(BoSS Japan)の結果から　　　　　　　　　　　　　　　
館農 勝, 加藤 隆弘, 青山 久美, 中野 和歌子, 中前 貴, 内田 直樹, 橋本 直樹, 菊地 紗耶, 和気 洋介, 藤澤 大介, 猪狩 圭介, 大塚 耕太郎, 高橋 克昌, 奥川 学, 渡辺 範雄, 白坂 知彦, Jovanovic Nikolina, Beezhold Julian, 精神神経学雑誌, 119, 2, 83, 97, Feb. 2017
(公社)日本精神神経学会, Japanese

メンタルヘルスファーストエイドプログラムの導入(第1報) 自殺予防対策における行政と事業所の協働　　　　　　　　　　　　　　　
平島 美也子, 永沼 純一, 上野 しおん, 浦田 裕美, 久保 浩明, 三井 敏子, 加藤 隆弘, 産業衛生学雑誌, 59, 1, 36, 36, Jan. 2017
(公社)日本産業衛生学会, Japanese

希死念慮をかかえるがん患者へのサポート(第5回) うつ病・「死にたい気持ち」への初期対応法 メンタルヘルス・ファーストエイド(Mental Health First Aid:MHFA)
早川 宏平, 久保 浩明, 近藤 恵子, 藤田 佐和, 加藤 隆弘, がん看護, 22, 1, 63, 66, Jan. 2017
(株)南江堂, Japanese

Psychiatric Lecture 病態 脳内免疫細胞ミクログリアに鑑みた精神疾患の病態理解　　　　　　　　　　　　　　　
加藤 隆弘, 精神科臨床Legato, 3, 1, 26, 29, Jan. 2017
(株)メディカルレビュー社, Japanese

日韓両国の精神医学・精神療法のパイオニアに聴く　　　　　　　　　　　　　　　
神庭 重信, 加藤 隆弘, 西園 昌久, 閔 秉根, 神田橋 條治, 内海 健, 九州神経精神医学, 62, 3-4, 150, 158, Dec. 2016
九州精神神経学会, Japanese

希死念慮をかかえるがん患者へのサポート(第4回) 自殺企図がある患者への対応・精神科診療との連携(2)
近藤 恵子, 早川 宏平, 加藤 隆弘, 藤田 佐和, がん看護, 21, 7, 733, 738, Nov. 2016
(株)南江堂, Japanese

うつ病概念を再考する
岩田 仲生, 岡本 泰昌, 功刀 浩, 加藤 隆弘, 精神科臨床Legato, 2, 4, 168, 176, Oct. 2016
(株)メディカルレビュー社, Japanese

脳内免疫細胞ミクログリアが無意識的欲動を司る?　　　　　　　　　　　　　　　
加藤 隆弘, ヘルスカウンセリング学会年報, 22, 65, 72, Sep. 2016
(NPO)ヘルスカウンセリング学会, Japanese

【臨床知に根ざした神経科学を担う人材育成】 ミクログリア研究で精神分析学・精神病理学を再解釈する試み
加藤 隆弘, 日本生物学的精神医学会誌, 27, 3, 151, 157, Sep. 2016
日本生物学的精神医学会, Japanese

【ミクログリアと疼痛】 疼痛におけるミクログリア仮説解明のための橋渡し研究 ヒト末梢血由来ミクログリア様細胞(iMG細胞)の臨床研究応用　　　　　　　　　　　　　　　
扇谷 昌宏, 加藤 隆弘, 細井 昌子, 神庭 重信, 細胞, 48, 8, 369, 372, Aug. 2016
(株)ニュー・サイエンス社, Japanese

慢性疼痛の病態解明と創薬への試み 線維筋痛症の病態解明に向けたトランスレーショナル研究 ミクログリアの異常活性化とTNF-α　　　　　　　　　　　　　　　
扇谷 昌宏, 加藤 隆弘, 細井 昌子, 津田 誠, 早川 宏平, 橋本 亮太, 須藤 信行, 神庭 重信, 日本神経精神薬理学会年会プログラム・抄録集, 46回, 128, 128, Jul. 2016
(一社)日本神経精神薬理学会, Japanese

希死念慮をかかえるがん患者へのサポート(第3回) 自殺企図がある患者への対応・精神科診療との連携【1】
近藤 恵子, 早川 宏平, 加藤 隆弘, 藤田 佐和, がん看護, 21, 5, 547, 552, Jul. 2016
(株)南江堂, Japanese

精神科領域の用語解説 ミクログリア　　　　　　　　　　　　　　　
加藤 隆弘, 扇谷 昌宏, 神庭 重信, 分子精神医学, 16, 3, 192, 194, Jul. 2016
(株)先端医学社, Japanese

【精神療法としての集団精神療法】 日本での集団精神療法実践における「先生転移」の功罪(序論)　　　　　　　　　　　　　　　
加藤 隆弘, 集団精神療法, 32, 1, 45, 51, Jun. 2016
(一社)日本集団精神療法学会, Japanese

希死念慮をかかえるがん患者へのサポート(第2回) がん患者の「死にたい気持ち」に耳を傾けることの大切さ 希死念慮・抑うつのアセスメント、精神科診療との連携
近藤 恵子, 早川 宏平, 加藤 隆弘, 藤田 佐和, がん看護, 21, 4, 460, 463, May 2016
(株)南江堂, Japanese

【これでいいのか うつ病治療:どうしたらいい よくならない抑うつ症状II】 長く続く抑うつ症状への治療・支援戦略 現代抑うつ症候群(現代うつ・新型うつ)に対する多軸的評価システムの構築 大学病院気分障害外来での取り組み紹介　　　　　　　　　　　　　　　
加藤 隆弘, 早川 宏平, 佐藤 美那, 下川 憲宏, 久保 浩明, 香月 亮子, 井上 綾子, 倉原 啓太, 堀川 英喜, 田中 耕司, 神庭 重信, 精神科臨床サービス, 16, 2, 183, 191, May 2016
(株)星和書店, Japanese

【こころの診療ファーストエイド】 メンタルヘルス・ファーストエイド 医療従事者向けのメンタルヘルス・ファーストエイドに則した短期教育研修プログラム　　　　　　　　　　　　　　　
加藤 隆弘, 久保 浩明, 早川 宏平, 佐藤 美那, 下川 憲宏, 赤司 浩一, 神庭 重信, 治療, 98, 5, 667, 673, May 2016
(株)南山堂, Japanese

2型糖尿病患者における5年後の外来医療費の変化に影響する因子　　　　　　　　　　　　　　　
田中 麻理, 伊藤 裕之, 尾本 貴志, 篠崎 正浩, 西尾 真也, 阿部 眞理子, 安徳 進一, 三舩 瑞夫, 当金 美智子, 加藤 隆弘, 加藤 正弘, 糖尿病, 59, 4, 188, 195, Apr. 2016
(一社)日本糖尿病学会, Japanese

気分障害患者由来誘導ミクログリア細胞を用いた病態・薬効評価システム開発　　　　　　　　　　　　　　　
扇谷 昌宏, 加藤 隆弘, 細井 昌子, 神庭 重信, 先進医薬研究振興財団研究成果報告集, 2015年度, 56, 57, Mar. 2016
(公財)先進医薬研究振興財団, Japanese

希死念慮をかかえるがん患者へのサポート がん患者の「死にたい気持ち」に耳を傾けることの大切さ 希死念慮・抑うつのアセスメント、精神科診療との連携
近藤 恵子, 早川 宏平, 加藤 隆弘, 藤田 佐和, がん看護, 21, 3, 376, 380, Mar. 2016
(株)南江堂, Japanese

【神経炎症・酸化ストレスをキーワードにした精神疾患の理解】 こころのミクログリア仮説解明に向けたトランスレーショナル研究
加藤 隆弘, 扇谷 昌宏, 渡部 幹, 神庭 重信, 日本生物学的精神医学会誌, 27, 1, 2, 7, Mar. 2016
日本生物学的精神医学会, Japanese

Multidimensional anatomy of 'modern type depression' in Japan: A proposal for a different diagnostic approach to depression beyond the DSM-5
Takahiro A. Kato, Ryota Hashimoto, Kohei Hayakawa, Hiroaki Kubo, Motoki Watabe, Alan R. Teo, Shigenobu Kanba, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 70, 1, 7, 23, Jan. 2016, [Peer-reviewed]
English, Book review

Directly Induced Glial/Neuronal Cells from Human Peripheral Tissues: A Novel Translational Research Tool for Neuropsychiatric Disorders
Takahiro A. Kato, Masahiro Ohgidani, Noriaki Sagata, Shigenobu Kanba, Advances in Neuroimmune Biology, 6, 2, 95, 105, 2016
IOS Press, English, Book review

第17回 日韓若手精神科医による合同研修会報告
鈴木 宗幸, 江渕 有希, 茅野 龍馬, 趙 岳人, 久我 弘典, 長 徹二, 田中 増郎, 青山 久美, 藤本 美智子, 加藤 隆弘, 九州神経精神医学, 62, 3, 143, 149, 2016
九州精神神経学会, Japanese

【グリア研究の最先端】 ヒト疾患グリア病 精神疾患のミクログリア仮説解明のための橋渡し研究
加藤 隆弘, 扇谷 昌宏, 神庭 重信, 生体の科学, 66, 6, 584, 588, Dec. 2015
(公財)金原一郎記念医学医療振興財団, Japanese

【ひきこもりの諸相】 社会的ひきこもりに関する日本、米国、韓国、インドでの国際共同調査の紹介　　　　　　　　　　　　　　　
加藤 隆弘, Teo Alan R, 館農 勝, Choi Tae Young, Balhara Yatan, Pal Singh, 神庭 重信, 臨床精神医学, 44, 12, 1625, 1635, Dec. 2015
(株)アークメディア, Japanese

【免疫と精神神経疾患】 免疫と統合失調症 ミクログリア仮説　　　　　　　　　　　　　　　
加藤 隆弘, 神庭 重信, 精神科, 27, 4, 228, 233, Oct. 2015
(有)科学評論社, Japanese

精神疾患における客観的な補助診断法の最前線 うつ病の病態を反映する血中バイオマーカーの開発・実用化研究　　　　　　　　　　　　　　　
神庭 重信, 尾崎 紀夫, 橋本 亮太, 功刀 浩, 服部 功太郎, 清水 栄司, 加藤 忠史, 加藤 隆弘, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 37回・45回, 143, 143, Sep. 2015
日本生物学的精神医学会・日本神経精神薬理学会, Japanese

【グリアアセンブリの生理と病態】 精神疾患患者のミクログリア活性化特性と精神病理現象との相関を解明するためのトランスレーショナル研究
加藤 隆弘, 扇谷 昌宏, 渡部 幹, 神庭 重信, 日本生物学的精神医学会誌, 26, 3, 140, 145, Sep. 2015
日本生物学的精神医学会, Japanese

ストレスと心身相関 ストレスとミクログリア トランスレーショナル研究　　　　　　　　　　　　　　　
加藤 隆弘, 扇谷 昌宏, 早川 宏平, 渡部 幹, 神庭 重信, ストレス科学, 29, 4, 373, 388, Jun. 2015
日本ストレス学会, Japanese

Introducing directly induced microglia-like (iMG) cells from fresh human monocytes: a novel translational research tool for psychiatric disorders
Masahiro Ohgidani, Takahiro A. Kato, Shigenobu Kanba, FRONTIERS IN CELLULAR NEUROSCIENCE, 9, 184, May 2015, [Peer-reviewed]
English

統合失調症の病態治療機構におけるレドックスとミクログリア
加藤 隆弘, 兵藤 文紀, 大和 真由実, 内海 英雄, 神庭 重信, 薬学雑誌, 135, 5, 739, 743, May 2015
(公社)日本薬学会, Japanese

うつ病特異的な社会的意志決定機序と脳内ミクログリア活動の相関解明 神経経済学研究　　　　　　　　　　　　　　　
加藤 隆弘, 堀川 英喜, 渡部 幹, 扇谷 昌宏, 佐方 功明, 早川 宏平, 下川 憲宏, 久保 浩明, 佐藤 美那, 池田 祥恵, 神庭 重信, 先進医薬研究振興財団研究成果報告集, 2014年度, 54, 55, Mar. 2015
(公財)先進医薬研究振興財団, Japanese

Introducing Hikikomori from multidimensional perspectives. Interview, World Child & Adolescent Psychiatry　　　　　　　　　　　　　　　
Kato TA, WPA, Child and Adolescent Psychiatry Section's Official Journal, Dec. 2014, [Peer-reviewed]
WPA, Child and Adolescent Psychiatry Section's Official Journal, English

Translational psychiatric research focusing on microglia - does microglial modulation prevent psychosis?
Takahiro Kato, Shigenobu Kanba, EARLY INTERVENTION IN PSYCHIATRY, 8, 36, 36, Nov. 2014
English, Summary international conference

神経免疫やストレスホルモンにより発症する神経疾患 心理社会的ストレスとミクログリア ミクログリア仮説解明のための橋渡し研究(Neuronal deseases and neuro-inflammation and hormone induced by stress Psychosocial stress and microglia-translational research focusing on human microglia)　　　　　　　　　　　　　　　
加藤 隆弘, 扇谷 昌宏, 神庭 重信, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 24回・44回, 113, 113, Nov. 2014
日本臨床精神神経薬理学会・日本神経精神薬理学会, English

Modeling brain diseases with direct induction technology of ramified microglia-like (iMG) cells from human monocytes
Masahiro Ohgidani, Takahiro A. Kato, Shigenobu Kanba, JOURNAL OF NEUROIMMUNOLOGY, 275, 1-2, 120, 120, Oct. 2014
English, Summary international conference

ストレスと心身相関 ストレスとミクログリア 齧歯類モデルの知見とヒト血液由来直接誘導ミクログリア様細胞作製技術の応用　　　　　　　　　　　　　　　
加藤 隆弘, 扇谷 昌宏, 神庭 重信, ストレス科学, 29, 2, 165, 165, Oct. 2014
日本ストレス学会, Japanese

【文化精神医学再考】 (第2部)文化精神医学再考 脳・文化・無意識 ミクログリア仮説から鑑みたエディプスコンプレックスの発生論(試論)　　　　　　　　　　　　　　　
加藤 隆弘, こころと文化, 13, 2, 116, 127, Sep. 2014
多文化間精神医学会, Japanese

【炎症の観点からみた精神疾患とストレス】 気分障害と糖尿病との炎症を介した共通基盤　　　　　　　　　　　　　　　
加藤 隆弘, 園田 紀之, 精神科, 25, 2, 135, 140, Aug. 2014
(有)科学評論社, Japanese

生体内レドックス反応を可視化する 装置開発から病態応用まで 統合失調症とレドックス ReMIの統合失調症モデルへの応用　　　　　　　　　　　　　　　
加藤 隆弘, 兵藤 文紀, 大和 真由実, 内海 英雄, 神庭 重信, 日本薬学会年会要旨集, 134年会, 1, 96, 96, Mar. 2014
(公社)日本薬学会, Japanese

Microglial hypothesis of schizophrenia
Shigenobu Kanba, Takahiro Kato, JAPANESE JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 34, 1, 11, 13, Feb. 2014
Japanese, Book review

統合失調症のミクログリア仮説　　　　　　　　　　　　　　　
神庭 重信, 加藤 隆弘, 日本神経精神薬理学雑誌, 34, 1, 11, 13, Feb. 2014
(一社)日本神経精神薬理学会, Japanese

私の診療経験から こころの応急対応(メンタルヘルス・ファーストエイド) 日常臨床場面における、うつ病の早期介入と自殺予防　　　　　　　　　　　　　　　
加藤 隆弘, 大塚 耕太郎, 鈴木 友理子, 藤澤 大介, 佐藤 玲子, 青山 久美, 橋本 直樹, 鈴木 志麻子, 神庭 重信, 臨牀と研究, 91, 2, 289, 294, Feb. 2014
大道学館出版部, Japanese

【精神障害患者の身体合併症-「偶発的な出来事」から「日常的に注意を向けるべき病態」へ-】 精神免疫学から観た身体疾患と精神疾患の生物学的共通基盤　　　　　　　　　　　　　　　
早川 宏平, 加藤 隆弘, 神庭 重信, 精神科治療学, 29, 2, 171, 178, Feb. 2014
(株)星和書店, Japanese

【精神疾患の病理機構】 ミクログリアと精神疾患
加藤 隆弘, 神庭 重信, 生体の科学, 65, 1, 37, 42, Feb. 2014
(公財)金原一郎記念医学医療振興財団, Japanese

Translational research of neuropsychiatric disorders focusing on microglia
Takahiro Kato, Shigenobu Kanba, JOURNAL OF PHARMACOLOGICAL SCIENCES, 124, 33P, 33P, 2014
English, Summary international conference

【慢性炎症と精神疾患】 慢性炎症と統合失調症 脳内免疫細胞ミクログリアの観点から　　　　　　　　　　　　　　　
加藤 隆弘, 関 善弘, 堀川 英喜, 扇谷 昌宏, 佐方 功明, 佐藤 美那, 山内 佑允, 早川 宏平, 下川 憲宏, 神庭 重信, 分子精神医学, 14, 1, 15, 22, Jan. 2014
(株)先端医学社, Japanese

精神科以外の臨床場面におけるメンタルヘルス・ファーストエイドを活用した、うつ病の早期介入と自殺予防　　　　　　　　　　　　　　　
加藤 隆弘, 筑紫, 38, 3, 37, 41, Jan. 2014
(一社)筑紫医師会, Japanese

[学会発表の仕方](第11回)(最終回) 国際シンポジウムの開き方　　　　　　　　　　　　　　　
青山 久美, 加藤 隆弘, 精神科治療学, 28, 11, 1527, 1530, Nov. 2013
(株)星和書店, Japanese

終末期癌患者のせん妄に対して抗生物質ミノサイクリンが著効した2例　　　　　　　　　　　　　　　
早川 宏平, 加藤 隆弘, 神代 正臣, 神庭 重信, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 23回・43回, 176, 176, Oct. 2013
日本臨床精神神経薬理学会・日本神経精神薬理学会, Japanese

メタンフェタミン投与マウスの逆耐性現象に対するミノサイクリン単回投与の抑制効果(A single-shot minocycline inhibits methamphetamine-induced behavioral sensitization in mice)　　　　　　　　　　　　　　　
佐方 功明, 加藤 隆弘, 大和 真由実, 芝 武志, 峰 宝, 関 善弘, 扇谷 昌宏, 山田 健一, 門司 晃, 神庭 重信, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 23回・43回, 227, 227, Oct. 2013
日本臨床精神神経薬理学会・日本神経精神薬理学会, English

精神病理と脳 精神分析と脳科学 ミクログリアは『死の欲動』の起源か?　　　　　　　　　　　　　　　
加藤 隆弘, 臨床精神病理, 34, 2, 233, 240, Aug. 2013
日本精神病理学会, Japanese

Missing and possible link between neuroendocrine factors, neuropsychiatric disorders and microglia
Takahiro A. Kato, Kohei Hayakawa, Akira Monji, Shigenobu Kanba, Frontiers in Integrative Neuroscience, 7, 53, 02 Jul. 2013, [Peer-reviewed]
English

Hikikomori phenomenon and psychiatric disorders
Masaru Tateno, Takahiro Kato, Alan Teo, Toshikazu Saito, EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 22, S224, S224, Jul. 2013
English, Summary international conference

Mental Health First Aid-Japanチームの活動について
大塚 耕太郎, 鈴木 友理子, 藤澤 大介, 加藤 隆弘, 佐藤 玲子, 青山 久美, 橋本 直樹, 鈴木 志麻子, 黒澤 美枝, 精神神経学雑誌, 115, 7, 792, 796, Jul. 2013
(公社)日本精神神経学会, Japanese

抗生物質ミノサイクリン投与によりせん妄が改善した一例　　　　　　　　　　　　　　　
早川 宏平, 加藤 隆弘, 神代 正臣, 神庭 重信, 精神神経学雑誌, 2013特別, S, 561, May 2013
(公社)日本精神神経学会, Japanese

社会的相互性と信頼ゲーム ミクログリア仮説に基づく神経精神分析学的接近　　　　　　　　　　　　　　　
加藤 隆弘, 渡部 幹, 神庭 重信, 精神神経学雑誌, 2013特別, S, 627, May 2013
(公社)日本精神神経学会, Japanese

【うつ病を「客観的に」診断するとは?-どこからが病気か-】 うつ病の診断に、本人からの問診のみでよいのか?　　　　　　　　　　　　　　　
橋本 亮太, 安田 由華, 山森 英長, 藤本 美智子, 住吉 太幹, 加藤 隆弘, 工藤 耕太郎, 神庭 重信, 武田 雅俊, 福井大学連合小児発達学研究科附属子どものこころの分子統御機構研究センター, 精神科, 22, 3, 243, 249, Mar. 2013
(有)科学評論社, Japanese

神経免疫系、ニューロン・グリア相互作用とうつ病　　　　　　　　　　　　　　　
堀川 英喜, 加藤 隆弘, 山内 佑允, 早川 宏平, 佐藤 美那, 関 善弘, 溝口 義人, 門司 晃, 神庭 重信, 精神薬療研究年報, 45, 93, 94, Mar. 2013
(公財)先進医薬研究振興財団, Japanese

Are microglia minding us? Digging up the unconscious mind-brain relationship from a neuropsychoanalytic approach.
Kato TA, Kanba S, Frontiers in human neuroscience, 7, 13, 2013, [Peer-reviewed]

Neuron-glia interaction as a possible glue to translate the mind-brain gap: A novel multi-dimensional approach toward psychology and psychiatry
Takahiro A. Kato, Motoki Watabe, Shigenobu Kanba, Frontiers in Psychiatry, 4, 139, 2013, [Peer-reviewed]
Frontiers Research Foundation, English

Neurotransmitters, psychotropic drugs and microglia: Clinical implications for psychiatry
T. A. Kato, Y. Yamauchi, H. Horikawa, A. Monji, Y. Mizoguchi, Y. Seki, K. Hayakawa, H. Utsumi, S. Kanba, Current Medicinal Chemistry, 20, 3, 331, 344, Jan. 2013, [Peer-reviewed]
English

【心と体のクロストークから解く 精神・神経疾患 発症基盤・病態生理を担う分子カスケードから臨床応用まで】 (第I部)精神・神経疾患の最前線 心と体のクロストーク (第1章)精神・神経疾患の最近のトピックス 体との接点 気分障害と糖尿病のクロストークとその病態基盤　　　　　　　　　　　　　　　
加藤 隆弘, 園田 紀之, 井口 登與志, 神庭 重信, 実験医学, 30, 13, 2008, 2012, Aug. 2012
(株)羊土社, Japanese

Inhibition of Chymase Protects Against Brain Oxidative Stress and Cognitive Dysfunction in Diabetic db/db Mice
Eiichi Hirata, Noriyuki Sonoda, Yohei Minami, Takahiro Kato, Yoshihiro Seki, Akira Monji, Ryoichi Takayanagi, Toyoshi Inoguchi, DIABETES, 61, A145, A146, Jun. 2012
English, Summary international conference

ひきこもりの精神医学的意義 文化依存症候群か普遍的現象か ひきこもりに関する国際共同調査 ひきこもりは海外にも存在するのか?　　　　　　　　　　　　　　　
加藤 隆弘, 館農 勝, 新福 尚隆, 神庭 重信, 精神神経学雑誌, 2012特別, S, 363, May 2012
(公社)日本精神神経学会, Japanese

神経免疫仮説に基づく精神障害の病態生理の研究 PolyI:C投与モデルから　　　　　　　　　　　　　　　
笠井 美那, 関 義弘, 堀川 英喜, 加藤 隆弘, 溝口 義人, 門司 晃, 神庭 重信, 九州神経精神医学, 57, 3-4, 143, 143, Dec. 2011
九州精神神経学会, Japanese

【脳の機能と統合失調症-新たな診断と治療への展望-II】 ミクログリアの機能から見た統合失調症　　　　　　　　　　　　　　　
加藤 隆弘, 精神科治療学, 26, 12, 1571, 1580, Dec. 2011
(株)星和書店, Japanese

初期臨床研修医における、患者の自殺行動への対処スキル　　　　　　　　　　　　　　　
藤澤 大介, 鈴木 友理子, 加藤 隆弘, 橋本 直樹, 佐藤 玲子, 上原 久美, 深澤 舞子, 冨田 真幸, 渡邊 衡一郎, 鹿島 晴雄, 大塚 耕太郎, 精神神経学雑誌, 2011特別, S, 217, Oct. 2011
(公社)日本精神神経学会, Japanese

精神科専門医の養成を考える 指導現場の取組と課題 若手指導医の視点から 精神科専門医申請者からみたプログラムの課題(専門医調査報告)　　　　　　　　　　　　　　　
中野 和歌子, 加藤 隆弘, 館農 勝, 内田 直樹, 中村 純, 精神神経学雑誌, 2011特別, S, 261, Oct. 2011
(公社)日本精神神経学会, Japanese

【神経免疫:多発性硬化症、脳虚血、アルツハイマー病、精神疾患における炎症反応と免疫異常】 精神疾患における脳内炎症免疫機構の意義 統合失調症のミクログリア仮説　　　　　　　　　　　　　　　
加藤 隆弘, 門司 晃, 神庭 重信, 細胞工学, 30, 10, 1046, 1053, Sep. 2011
(株)学研メディカル秀潤社, Japanese

新旧卒後臨床研修制度の外来教育に対する若手精神科医の意識調査 外来診療開始までの陪席期間について
中前 貴, 猪狩 圭介, 上原 久美, 加藤 隆弘, 田中 徹平, 中野 和歌子, 松本 良平, 精神医学, 53, 5, 497, 502, May 2011
精神科面接は、精神科医にとって身体科における各手技に相当する重要な技術であるにもかかわらず、いったん外来診療を任せられる立場になると、実際に他の医師の診察場面を見て学ぶ機会が激減する。すなわち外来診療を開始する前に、指導医の外来診療を陪席することは、精神科医にとって外来教育を受ける貴重な機会である。にもかかわらず、本診にも再来にも同席しないという、いわゆる予診番のような体制が増えているという現状は、後期研修における改善するべき問題点の1つと考えられる。本研究の調査結果からは、予診をとった患者の本診だけでなく、再来にも陪席するという体制で15ヵ月以上の陪席経験を積むことが陪席期間に対する充足度に寄与すると考えられたが、今後、外来診療開始時期と、開始後の指導体制ならびにその効果に関する検討も必要と示唆された。, (株)医学書院, Japanese

アンケート調査に基づくひきこもりの精神医学的背景に関する検討　　　　　　　　　　　　　　　
館農 勝, 佐々木 竜二, 中野 和歌子, 加藤 隆弘, 鈴木 康世, 松山 清治, 氏家 武, 齋藤 利和, 精神科, 18, 5, 600, 606, May 2011
医師や看護師、心理士、学生といった多職種の者を対象に、ひきこもりの精神医学的背景について検討するためのアンケート調査を実施した。その結果、医療機関を訪れるひきこもりに関しては、その多くが既存の診断基準で精神障害の診断が可能であると考えられるが、診断基準を満たさない「中核群」とされるひきこもりの存在を無視できないと思われた。ひきこもりは、疾病でもなければ狭義の医学的治療の対象でもない現象とする考えや、ひきこもりが広い意味での若者の不適応問題の一つであり、かならずしも全例が治療対象とならないという意見もあった。その一方で、ひきこもりは過剰なほどに均質であることを志向する日本人の国民性を反映した文化依存症候群であるという指摘もあった。, (有)科学評論社, Japanese

神経炎症の観点から見たうつ病の病態生理についての研究　　　　　　　　　　　　　　　
門司 晃, 加藤 隆弘, 溝口 義人, 堀川 英喜, 関 義弘, 後藤 玲央, 笠井 美那, 神庭 重信, 精神薬療研究年報, 43, 65, 69, Mar. 2011
(公財)先進医薬研究振興財団, Japanese

【精神科専門医取得のための研修にかかわる問題点】 新規の専門医制度における精神科後期研修を経験した立場から　　　　　　　　　　　　　　　
中野 和歌子, 内田 直樹, 加藤 隆弘, 館農 勝, 松本 良平, 中村 純, 精神神経学雑誌, 113, 3, 271, 276, Mar. 2011
(公社)日本精神神経学会, Japanese

Possible role of BDNF-induced microglial intracellular ca2+ elevation in the pathophysiology of neuropsychiatric disorders
Y. Mizoguchi, A. Monji, T. A. Kato, H. Horikawa, Y. Seki, M. Kasai, S. Kanba, S. Yamada, Mini-Reviews in Medicinal Chemistry, 11, 7, 575, 581, 2011, [Peer-reviewed]
English

Anti-inflammatory properties of antipsychotics via microglia modulations: Are antipsychotics a 'fire extinguisher' in the brain of schizophrenia?
T. A. Kato, A. Monji, Y. Mizoguchi, S. Hashioka, H. Horikawa, Y. Seki, M. Kasai, H. Kasai, H. Utsumi, S. Kanba, Mini-Reviews in Medicinal Chemistry, 11, 7, 565, 574, 2011, [Peer-reviewed]
English

Potential roles of microglia in psychiatric diseases
Shigenobu Kanba, Akira Monji, Takahiro Kato, Hideki Horikawa, Mina Kasai, Yoshito Mizoguchi, NEUROSCIENCE RESEARCH, 71, E8, E9, 2011
English, Summary international conference

Successful treatment of chronic urticaria with a Japanese herbal medicine, yokukansan
Shiori Kato, Takahiro A. Kato, Haruko Nishie, Sankei Nishima, Tomoaki Iwanaga, Akira Monji, Misa Nakano, Hiromichi Takeshita, Masutaka Furue, JOURNAL OF DERMATOLOGY, 37, 12, 1066, 1067, Dec. 2010
English, Report scientific journal

【精神疾患の免疫異常】 精神疾患におけるミクログリアを介した神経免疫仮説　　　　　　　　　　　　　　　
加藤 隆弘, 日本生物学的精神医学会誌, 21, 4, 229, 236, Dec. 2010
日本生物学的精神医学会, Japanese

Bio-Psycho-Socialモデルと精神科研修 若手精神科医対象の国際パイロット調査　　　　　　　　　　　　　　　
加藤 隆弘, 館農 勝, 中野 和歌子, 藤澤 大介, 佐々木 竜二, 石田 哲也, 神庭 重信, 九州神経精神医学, 56, 3-4, 174, 174, Dec. 2010
九州精神神経学会, Japanese

新規専門医制度を経験した立場から　　　　　　　　　　　　　　　
中野 和歌子, 内田 直樹, 加藤 隆弘, 館農 勝, 松本 良平, 中村 純, 九州神経精神医学, 56, 3-4, 177, 177, Dec. 2010
九州精神神経学会, Japanese

Inhibitory effects of SSRIs on IFN-gamma induced microglial activation through the regulation of intracellular calcium
Hideki Horikawa, Takahiro A. Kato, Yoshito Mizoguchi, Akira Monji, Yoshihiro Seki, Takatoshi Ohkuri, Leo Gotoh, Megumi Yonaha, Tadashi Ueda, Sadayuki Hashioka, Shigenobu Kanba, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 34, 7, 1306, 1316, Oct. 2010
English, Book review

グリア細胞の機能変調と脳疾患 向精神薬のミクログリア抑制作用と精神疾患の神経炎症仮説(Glia pathology and brain diseases Inhibitory effects of psychotropics and neuro: inflammation hypothesis of psychoses)　　　　　　　　　　　　　　　
神庭 重信, 門司 晃, 加藤 隆弘, 堀川 英喜, 神経化学, 49, 2-3, 443, 443, Aug. 2010
日本神経化学会, English

うつ病の分子・細胞基盤 うつ病の神経炎症仮説(Molecular and cellular basis of depression Neuroinflamatory Hypothesis od Depression)　　　　　　　　　　　　　　　
神庭 重信, 門司 晃, 加藤 隆弘, 堀川 英喜, 橋岡 禎征, 神経化学, 49, 2-3, 457, 457, Aug. 2010
日本神経化学会, English

精神科的早期介入と偏見除去のための臨床研修医への短期教育法の効果に関するパイロット研究　　　　　　　　　　　　　　　
橋本 直樹, 鈴木 友理子, 加藤 隆弘, 佐藤 玲子, 藤澤 大介, 上原 久美, 神庭 重信, 大塚 耕太郎, 日本社会精神医学会雑誌, 19, 1, 121, 122, Jul. 2010
(一社)日本社会精神医学会, Japanese

若手精神科医における燃え尽き症候群に関する国際共同研究 日本国内調査(BoSS Japan)中間報告　　　　　　　　　　　　　　　
館農 勝, 加藤 隆弘, 上原 久美, 中野 和歌子, 中前 貴, 内田 直樹, 橋本 直樹, 菊地 紗耶, 和気 洋介, 藤沢 大介, 猪狩 圭介, 大塚 耕太郎, 高橋 克昌, 奥川 学, 渡辺 範雄, 白坂 知彦, 精神神経学雑誌, 2010特別, S, 210, May 2010
(公社)日本精神神経学会, Japanese

精神科専門医取得のための研修にかかわる問題点 新規の専門医制度における精神科後期研修を経験した立場から　　　　　　　　　　　　　　　
中野 和歌子, 内田 直樹, 加藤 隆弘, 館農 勝, 松本 良平, 中村 純, 精神神経学雑誌, 2010特別, S, 274, May 2010
(公社)日本精神神経学会, Japanese

初期臨床研修制度の現状と課題 若手精神科医を対象とした意識調査の結果から　　　　　　　　　　　　　　　
中野 和歌子, 加藤 隆弘, 館農 勝, 寶珠山 務, 中村 純, 精神神経学雑誌, 112, 4, 325, 335, Apr. 2010
精神科初期研修の現状や問題点を検討するため、2008年8月〜9月に国内15施設に所属する経歴10年以上の精神科医を対象に意識調査を実施した。その結果、初期臨床研修を経験した精神科医の92%は初期臨床研修に満足しており、41%が精神科初期研修後に精神科医になることを決断していた。研修期間・研修機関別で比較すると、3ヵ月以上精神科研修をした群では薬物療法の習得に関する自己評価が高く、精神科病院で研修した群では大学病院精神科や総合病院精神科で研修した群と比較して疾患の理解に関する自己評価が高かった。初期臨床研修の導入が精神科医への志望動機に大きな影響を与え、研修期間や研修機関の違いにより習得する項目に差を認める可能性が示唆された。, (公社)日本精神神経学会, Japanese

劇的精神分析を学ぶ.　　　　　　　　　　　　　　　
加藤隆弘, 精神分析研究, 54, 1, 35, 37, 2010

Development of 2-hour suicide intervention program among medical residents: First pilot trial
Takahiro A. Kato, Yuriko Suzuki, Ryoko Sato, Daisuke Fujisawa, Kumi Uehara, Naoki Hashimoto, Yasunori Sawayama, Jun Hayashi, Shigenobu Kanba, Kotaro Otsuka, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 64, 5, 531, 540, 2010
English

Inhibitory effects of psychotropics and neuro: inflammation hypothesis of psychoses
Shigenobu Kanba, Akira Monji, Takahiro Kato, Hideki Horikawa, NEUROSCIENCE RESEARCH, 68, E15, E15, 2010
English, Summary international conference

10年目までの精神科医を対象とした新旧精神科研修に関する意識調査 九州版　　　　　　　　　　　　　　　
中野 和歌子, 加藤 隆弘, 館農 勝, 中村 純, 九州神経精神医学, 55, 3-4, 170, 170, Dec. 2009
九州精神神経学会, Japanese

集団精神療法の学び方を学ぶ 特に「はじめの一歩」を獲得したい初学者のために　　　　　　　　　　　　　　　
加藤 隆弘, 青木 桃子, 入江 美保, 長谷川 麻弓, 堀 有伸, 田辺 等, 集団精神療法, 25, 2, 146, 151, Dec. 2009
(一社)日本集団精神療法学会, Japanese

精神科卒後教育を考える 新旧臨床研修制度を経験した若手精神科医の立場から 精神科卒後教育を精神科専門医制度に則った後期臨床研修医の立場から考える 大学病院における精神科後期研修　　　　　　　　　　　　　　　
中野 和歌子, 加藤 隆弘, 館農 勝, 猪狩 圭介, 田中 徹平, 中前 貴, 寶珠山 務, 中村 純, 精神神経学雑誌, 111, 10, 1214, 1219, Oct. 2009
(公社)日本精神神経学会, Japanese

精神科卒後教育を考える 新旧臨床研修制度を経験した若手精神科医の立場から 「精神科医への道」再考 海外の若手精神科医との交流から学ぶ　　　　　　　　　　　　　　　
加藤 隆弘, 舘農 勝, 中野 和歌子, Balhara Yatan, Pal Singh, Teo Alan R, 藤澤 大介, 佐々木 竜二, 内田 舞, 精神神経学雑誌, 111, 10, 1226, 1233, Oct. 2009
(公社)日本精神神経学会, Japanese

Post-graduate Psychiatric Training in Asia(アジアにおける精神科卒後研修) Postgraduate Psychiatric Training in Japan(日本の精神科卒後教育)　　　　　　　　　　　　　　　
中野 和歌子, 加藤 隆弘, 館農 勝, 中村 純, 精神神経学雑誌, 111, 10, 1246, 1249, Oct. 2009
(公社)日本精神神経学会, Japanese

私の論文から 統合失調症、抗精神病薬、そして、ミクログリア 臨床的着想を基礎研究に活かす　　　　　　　　　　　　　　　
加藤 隆弘, 九州神経精神医学, 55, 2, 125, 131, Aug. 2009
九州精神神経学会, Japanese

東北地方の精神科医の勤務実態調査報告　　　　　　　　　　　　　　　
菊地 紗耶, 正宗 弥生, 橋本 直樹, 上原 久美, 加藤 隆弘, 吹田 恭子, 藤本 美智子, 安保 英勇, 松岡 洋夫, 精神神経学雑誌, 111, 6, 706, 706, Jun. 2009
(公社)日本精神神経学会, Japanese

精神科卒後教育を考える 新旧臨床研修制度を経験した若手精神科医の立場から 精神科卒後教育を精神科専門医制度に則った後期臨床研修医の立場から考える　　　　　　　　　　　　　　　
中野 和歌子, 加藤 隆弘, 館農 勝, 猪狩 圭介, 田中 徹平, 中前 貴, 中村 純, 精神神経学雑誌, 2009特別, S, 207, May 2009
(公社)日本精神神経学会, Japanese

精神科卒後教育を考える 新旧臨床研修制度を経験した若手精神科医の立場から 従来のストレート研修のメリット・デメリット　　　　　　　　　　　　　　　
中前 貴, 猪狩 圭介, 加藤 隆弘, 田中 徹平, 中野 和歌子, 精神神経学雑誌, 2009特別, S, 208, May 2009
(公社)日本精神神経学会, Japanese

精神科卒後教育を考える 新旧臨床研修制度を経験した若手精神科医の立場から 「精神科医への道」再考 海外の若手精神科医との交流から学ぶ　　　　　　　　　　　　　　　
加藤 隆弘, 館農 勝, 中野 和歌子, 内田 舞, 精神神経学雑誌, 2009特別, S, 209, May 2009
(公社)日本精神神経学会, Japanese

臨床研修医を対象とした、自殺対応スキルおよび偏見除去に関する研修法の効果に関するパイロット研究　　　　　　　　　　　　　　　
鈴木 友理子, 加藤 隆弘, 佐藤 玲子, 藤澤 大介, 上原 久美, 橋本 直樹, 神庭 重信, 大塚 耕太郎, 精神神経学雑誌, 2009特別, S, 310, May 2009
(公社)日本精神神経学会, Japanese

若手精神科医は、いかにして児童精神医学に興味を持つのか 若手精神科医を対象とした意識調査の結果から　　　　　　　　　　　　　　　
館農 勝, 菊地 紗耶, 中野 和歌子, 加藤 隆弘, 齋藤 利和, 精神神経学雑誌, 2009特別, S, 432, May 2009
(公社)日本精神神経学会, Japanese

若手精神科医の研修と相互交流の意義と課題 若手精神科医の研修と相互交流の意義と課題 学びの場、支えの場　　　　　　　　　　　　　　　
上原 久美, 加藤 隆弘, 橋本 直樹, 和気 洋介, 田中 徹平, 馬場 俊明, 藤澤 大介, 精神神経学雑誌, 111, 2, 221, 226, Feb. 2009
(公社)日本精神神経学会, Japanese

統合失調症、抗精神病薬、そして、ミクログリア－臨床的発想を基礎研究に活かす－.　　　　　　　　　　　　　　　
加藤隆弘, 九州神経精神医学, 55, 2, 125, 131, 2009

Cytokines and schizophrenia: Microglia hypothesis of schizophrenia
Akira Monji, Takahiro Kato, Shigenobu Kanba, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 63, 3, 257, 265, 2009
English, Book review

向精神薬のミクログリアを介した神経免疫調整作用に関する研究　　　　　　　　　　　　　　　
堀川 英喜, 加藤 隆弘, 溝口 義人, 門司 晃, 神庭 重信, 九州神経精神医学, 54, 3-4, 200, 201, Dec. 2008
九州精神神経学会, Japanese

Asian Young Psychiatrists’ International Workshop in the 104th Annual Meeting of the Japanese Society of Psychiatry and Neurology.　　　　　　　　　　　　　　　
Kato T, Baba T, Sugiura K, Tateno M, Balhara YPS, Sharifi V, Tseng HH, Zin NM, Kabir MS, Rahman H, Verman S, Rajkumar AP, Chand PK, Saisavoey N, Gill JS, Akiyama T, The Third Issue of WPA e-bulletin of the Region IV (Asia & Australasia), Nov. 2008
The Third Issue of WPA e-bulletin of the Region IV (Asia & Australasia), English

非定型抗精神病薬の活性化ミクログリアへの作用から統合失調症の病態機序を探る　　　　　　　　　　　　　　　
加藤 隆弘, 精神神経学雑誌, 110, 8, 706, 711, Aug. 2008
(公社)日本精神神経学会, Japanese

若手精神科医の研修と相互交流の意義と課題 若手精神科医の学びの場、支えの場 若手精神科医の研修と相互交流の意義と課題 学びの場、支えの場　　　　　　　　　　　　　　　
上原 久美, 加藤 隆弘, 橋本 直樹, 和気 洋介, 田中 徹平, 馬場 俊明, 藤澤 大介, 精神神経学雑誌, 2008特別, S, 298, May 2008
(公社)日本精神神経学会, Japanese

集団精神療法を学ぶ 私はどのようにして学んだか　　　　　　　　　　　　　　　
青木 桃子, 加藤 隆弘, 嶋田 博之, 田辺 等, 精神神経学雑誌, 2008特別, S, 362, May 2008
(公社)日本精神神経学会, Japanese

精神科医療に関する意識の変化 神奈川県精神医学会会員102人の意識調査から　　　　　　　　　　　　　　　
上原 久美, 杉浦 寛奈, 鎌田 鮎子, 辛島 文, 小西 潤, 近藤 大三, 福島 浩, 堀 岳人, 山本 めぐみ, 橋本 直樹, 加藤 隆弘, 藤澤 大介, 小田原 俊成, 平安 良雄, 精神神経学雑誌, 110, 4, 338, 339, Apr. 2008
(公社)日本精神神経学会, Japanese

若手精神科医の育成と研修環境 神奈川県精神医学会会員を対象とした意識調査から　　　　　　　　　　　　　　　
上原 久美, 杉浦 寛奈, 鎌田 鮎子, 辛島 文, 小西 潤, 近藤 大三, 福島 浩, 堀 岳人, 山本 めぐみ, 藤澤 大介, 橋本 直樹, 加藤 隆弘, 神奈川県精神医学会誌, 57, 75, 81, Mar. 2008
神奈川県精神医学会会員を対象に、若手医師の育成と研修環境についての意識調査を実施し、102名から有効回答を得た。その結果、勤務先ごとの興味ある分野の調査については、大学や総合病院では薬理学的な興味が、クリニックや精神科単科病院では精神病理への興味が高く、職場によって重視する内容が異なる傾向がみられた。卒後20年以内の精神科医の約7割が精神科医となって3年以内に大学病院での勤務を経験していた。大学病院の医局のどのようなところを評価するかという質問に対し、1年目は研修を一番に挙げているが、2〜10年目は医局員同士の交流を挙げており、大学病院の医局が、研修そのものだけでなく、精神科医同士の相互交流にも貢献していることが示唆された。, 神奈川県精神医学会, Japanese

非定型抗精神病薬の活性化ミクログリアへの作用から統合失調症の病態機序を探る (精神医学奨励賞受賞講演記録).　　　　　　　　　　　　　　　
加藤隆弘, 精神神経学雑誌, 110, 8, 706, 711, 2008
精神神経学雑誌 110巻8号, Japanese

The Significance of Communicating with Neighbors for Young Psychiatrists.　　　　　　　　　　　　　　　
Kato T, World Cultural Psychiatry Research Review, 3, 4, 219, 225, 2008
World Cultural Psychiatry Research Review, English

精神科医としての専門性について考える 専門性を獲得する途にある若手精神科医の現場からの声 大学病院での精神科研修について 新制度で後期研修を始めた新しい精神科医第一号の立場から　　　　　　　　　　　　　　　
宮島 加耶, 藤澤 大介, 中川 敦夫, 加藤 隆弘, 精神神経学雑誌, 109, 11, 1039, 1044, Nov. 2007
(公社)日本精神神経学会, Japanese

精神科医としての専門性について考える 専門性を獲得する途にある若手精神科医の現場からの声 専門性を獲得する途にある若手精神科医の現状と課題 精神科研修及び精神医療・精神医学に関する意識調査　　　　　　　　　　　　　　　
加藤 隆弘, 橋本 直樹, 佐藤 玲子, 小泉 弥生, 中川 敦夫, 藤澤 大介, 上原 久美, 精神神経学雑誌, 109, 11, 1045, 1049, Nov. 2007
平成16年度より新臨床研修制度・精神科専門医制度が始動し、新制度のもとで初期研修を終了した臨床研修医が平成18年度から新しい時代の精神科第一号として後期研修を始めた。この過渡期に、従来の研修システムで育った精神科医の現状・実態を把握するため、北海道精神神経学会の若手医師と神奈川県精神医学会会員を対象にアンケート調査を実施した。その結果、精神科医への志望動機は「心への関心」という回答が圧倒的に多かったが、「精神科医は脳の医者か、心の医者か」との質問に対しては、若手精神科医の半数以上は「両方だがどちらかというと脳の医者である」と回答し、薬物療法と比較して精神療法に関する知識・技能が不十分であると回答した。, (公社)日本精神神経学会, Japanese

新医師精神科臨床研修のアウトカム評価 新医師精神科臨床研修のアウトカム評価 日本若手精神科医の会の多施設調査結果から　　　　　　　　　　　　　　　
佐藤 玲子, 加藤 隆弘, 末永 貴美, 藤澤 大介, 上原 久美, 精神神経学雑誌, 109, 11, 1072, 1081, Nov. 2007
研修医や若手精神科医の新臨床研修制度への意識や、研修の実施状況、問題点を明らかにするため多施設アンケート調査を実施した。精神科研修を受けた研修医を対象とした。実践的な知識・技術を求める研修医のニーズを必ずしも満たしているとはいえないが、症状・疾患の知識が増え、患者との接し方に対する不安が減じたという自己評価が、研修医の回答では多かった。指導医側の回答からは、人員・時間の不足を研修上の問題点として挙げるものが多かった。研修前の認知度が低い疾患は、研修後の習得度も低い傾向があるという相関を認めた。, (公社)日本精神神経学会, Japanese

12^ Pacific Rim College of Psychiatrists (PRCP : 環太平洋精神医学会) Scientific Meeting および Mental Health Policy Workshop に参加して
和気 洋介, 佐藤 創一郎, 橋本 直樹, 加藤 隆弘, 馬場 俊明, 内田 直樹, 澤田 健, 小泉 弥生, 中川 敦夫, 館農 勝, 上原 久美, 精神神經學雜誌 = Psychiatria et neurologia Japonica, 109, 10, 921, 924, 25 Oct. 2007
日本精神神経学会, Japanese

日本における精神科疾病分類(ICDおよびDSM)に関するアンケート調査 New Zealandとの比較も踏まえて
長峯 正典, 勝 強志, 加藤 隆弘, 上原 久美, 藤澤 大介, 佐藤 創一郎, 吉野 相英, 野村 総一郎, 新福 尚隆, 精神医学, 49, 10, 1045, 1052, Oct. 2007
本邦での精神科疾病分類に関するアンケート調査の結果を、New Zealandでの結果も交えて報告した。New Zealandで実施されたアンケートを翻訳し、本邦の実情に合うよう質問項目に診療地域・所属施設・精神科臨床経験年数を加えた。調査項目は、対象者に関する設問を7問、疾病分類に求める要件に関する設問を12問設定した。日本とNew ZealandではDSM(精神疾患の分類と診断の手引き)とICD(国際疾病分類)の使用のされ方が大きく異なった。特に、日本ではDSMとICDが大差なく使用されているのに対し、New Zealandでは圧倒的にDSMが普及している一方でICDはほとんど使用されていなかった。精神科疾病分類に関して、New Zealandでは日本と比較すると、より広い範囲で用いられるべきだとする意見がみられ、両国の医療制度や保険制度の違いが関与している可能性があった。, (株)医学書院, Japanese

精神科医としての専門性について考える 専門性を獲得する途にある若手精神科医の現場からの声 専門性を獲得する途にある若手精神科医の現状と課題 精神科研修及び精神医療・精神医学に関する意識調査　　　　　　　　　　　　　　　
加藤 隆弘, 橋本 直樹, 佐藤 玲子, 小泉 弥生, 中川 敦夫, 藤澤 大介, 上原 久美, 精神神経学雑誌, 2007特別, S140, S140, May 2007
(公社)日本精神神経学会, Japanese

新医師精神科臨床研修のアウトカム評価 日本若手精神科医の会の多施設調査の結果から　　　　　　　　　　　　　　　
佐藤 玲子, 加藤 隆弘, 末永 貴美, 藤澤 大介, 上原 久美, 精神神経学雑誌, 2007特別, S234, S234, May 2007
(公社)日本精神神経学会, Japanese

排除から創造への集団精神療法的過程 二十歳の入院治療　　　　　　　　　　　　　　　
加藤 隆弘, 集団精神療法, 22, 2, 172, 177, Mar. 2007
(一社)日本集団精神療法学会, Japanese

神奈川県における卒後研修に関する意識調査　　　　　　　　　　　　　　　
上原 久美, 杉浦 寛奈, 鎌田 鮎子, 辛島 文, 小西 潤, 近藤 大三, 福島 浩, 堀 岳人, 山本 めぐみ, 橋本 直樹, 加藤 隆弘, 日本若手精神科医の会, 卒後教育研究班, 神奈川県精神医学会誌, 56, 92, 93, Dec. 2006
神奈川県精神医学会, Japanese

The effect of atypical antipsychotic drugs on the production of proinflammatory cytokines, nitric oxide and reactive oxygen species by activated microglia
Takahiro Kato, Sadayuki Hashioka, Akira Monji, Yasukawa Keiji, Shigenobu Kanba, JOURNAL OF NEUROIMMUNOLOGY, 178, 180, 180, Sep. 2006
English, Summary international conference

カプグラ症候群の出現に伴い,SPECT所見に変化が見られたてんかん精神病の一例について　　　　　　　　　　　　　　　
堀川 英喜, 門司 晃, 佐々木 雅之, 鬼塚 俊明, 仁田坂 洋子, 前川 敏彦, 平野 羊嗣, 平野 昭吾, 橋岡 禎征, 加藤 隆弘, 吉田 一郎, 神庭 重信, 神経化学, 45, 2-3, 401, 401, Aug. 2006
日本神経化学会, Japanese

【神経症圏障害のすべて】 各論 全般性不安障害 治療　　　　　　　　　　　　　　　
加藤 隆弘, 門司 晃, 橋岡 禎征, 神庭 重信, 臨床精神医学, 35, 6, 801, 807, Jun. 2006
(株)アークメディア, Japanese

新卒後臨床研修制度における精神科研修の現状 日本若手精神科医の会による多施設アンケート調査　　　　　　　　　　　　　　　
佐藤 玲子, 加藤 隆弘, 末永 貴美, 縄田 秀幸, 吹田 恭子, 五十君 啓泰, 奥川 学, 菊地 紗耶, 菊地 俊暁, 館農 勝, 藤内 栄太, 藤田 晶子, 藤本 美智子, 宮田 純, 森 貴俊, 諸隈 一平, 山之内 芳雄, 上原 久美, 藤澤 大介, 精神神経学雑誌, 2006特別, S227, S227, May 2006
(公社)日本精神神経学会, Japanese

「日韓両国の若い精神科医のための合同研修会」に参加して 若い精神科医が異文化交流をおこなう意義について(The Significance of Cross-Cultural Experience for Young Psychiatrists: Learning from "The Joint Workshop for Psychiatric Residents of Korea and Japan")　　　　　　　　　　　　　　　
加藤 隆弘, 精神神経学雑誌, 2006特別, S303, S303, May 2006
(公社)日本精神神経学会, English

精神科受診経路に関する多施設研究(PATHWAY研究)(第3報) 身体科医療機関での治療についての満足度調査　　　　　　　　　　　　　　　
橋本 直樹, 藤澤 大介, 大塚 耕太郎, 小泉 弥生, 山之内 芳雄, 森 貴俊, 加藤 隆弘, 吹田 恭子, 館農 勝, 今村 弥生, 菊地 紗耶, 吉岡 知子, 佐藤 創一郎, 精神神経学雑誌, 2006特別, S350, S350, May 2006
(公社)日本精神神経学会, Japanese

Laminin and its related peptides for the treatment of Alzheimer's disease
Akira Monji, Ken-Ichiro Tashiro, Ichiro Yoshida, Sadayuki Hashioka, Takahiro Kato, Shigenobu Kanba, Current Medicinal Chemistry - Central Nervous System Agents, 5, 4, 243, 247, Dec. 2005
English, Book review

【精神医療の新しい潮流 内科診療のために】 抗うつ薬の作用機序　　　　　　　　　　　　　　　
橋岡 禎征, 門司 晃, 加藤 隆弘, 神庭 重信, 綜合臨床, 54, 12, 3011, 3017, Dec. 2005
(株)永井書店, Japanese

ホスファチジルセリンのリポソームはミクログリアの神経毒分子の産生を抑える(Phosphatidylserine-liposomes inhibit microglial production of neurotoxic molecules)　　　　　　　　　　　　　　　
橋岡 禎征, 韓 連煕, 加藤 隆弘, 門司 晃, 内海 英雄, 澤田 誠, 神庭 重信, 中西 博, 神経化学, 44, 2-3, 205, 205, Aug. 2005
日本神経化学会, English

集団精神療法テキストブック 総論編
日本集団精神療法学会, 2 体験グループ, 第3章 グループと研修
金剛出版, 26 Mar. 2025, 4772420940, 208, [Contributor]

学校でグループ・アプローチを活用する手引き スクールカウンセラー・教職員のためのメソッド　　　　　　　　　　　　　　　
加藤隆弘(相田信男監修, 大橋良枝, 梶本浩史編), 先生転移とその彼岸. 第４部学校の未来
遠見書房, Feb. 2025, [Contributor]

Handbook of the Biology and Pathology of Mental Disorders
Hayakawa K., Setoyama D., Kato TA, Schizoid Personality, Hikikomori, and Blood Biomarkers: A Focus on Lipidomics and Metabolomics
Springer, Cham, Oct. 2024, 1-17, [Contributor]

心のケアにたずさわる人が知っておきたい精神疾患とストレス関連疾患 病気の徴候に気づき、適切な治療・アプローチにつなげる！ 悪化をふせぐ！　　　　　　　　　　　　　　　
加藤隆弘, 第1章「精神疾患」 1,2,3 第3章「児童思春期の精神疾患・ストレス関連疾患」3,4,5
メディカ出版, Sep. 2024, 9784840485241

ひきこもりと令和型不登校－「幸せなひきこもり」か否かを見極めて支援する. 令和型不登校をあきらめない　　　　　　　　　　　　　　　
加藤隆弘, 134-147
こころの科学 SPECIAL ISSUE 2024, 日本評論社, Aug. 2024, [Contributor]

働く人のためのメンタルヘルス・ファーストエイド実践ガイド : メンタル不調者の対応に悩む人必見!
加藤, 隆弘, 小原, 圭司, 大塚, 耕太郎
メディカ出版, Jul. 2024, 9784840485012, 215p, Japanese

システマティック臨床精神医学 : 4つの多元的観点による治療体系化
Chisolm, Margaret S., Lyketsos, Constantine G., 澤, 明, 成田, 瑞, (訳) CASE4 2024多くの生活ストレスの中、抑うつがある男性 生活史か疾患か？
中外医学社, Jun. 2024, 9784498229600, x, 154p, Japanese, [Joint translation]

機能性神経障害診療ハンドブック : 脳神経内科,精神科,総合診療科のギャップを埋める!極める!
加藤隆弘(分担執筆)下畑, 享良(著者), 歴史から学ぶ(3):精神分析とヒステリー 脳神経科医フロイトによるヒステリーへの精神分析治療を振り返る.
中外医学社, May 2024, 9784498428164, 13,526p, Japanese, [Contributor]

「川の字」文化の深層心理学──親子の添い寝と「見るなの禁止」
北山修, 荻本快, 第8章 「先生転移」に覆われた「甘え」――「見るなの禁止」に隠された愛情への強い渇望
岩波書店, 22 Apr. 2024, 4000616374, 248, 181-199, [Contributor]

逃げるが勝ちの心得 : 精神科医がすすめる「うつ卒」と幸せなひきこもりライフ
加藤, 隆弘
木立の文庫, Jul. 2023, 9784909862303, iii, 204p, Japanese

働く仲間のこころの危機に気付いたら こころの応急手当～メンタルヘルス・ファーストエイドの活用～　　　　　　　　　　　　　　　
加藤隆弘, 小原圭司, 大塚耕太郎
中央労働災害防止協会, Feb. 2023

精神分析と脳科学が出会ったら? : 免疫細胞が生み出す快と不快の不協和音 = What if psychoanalysis and neuroscience meet?
加藤, 隆弘
日本評論社, Sep. 2022, 9784535985155, 246p, Japanese

Stress, Microglial activation, and Mental disorders. Stress-Related Disorders［Working Title］　　　　　　　　　　　　　　　
Enomoto S, Kato TA
Intec Open, London, UK, Apr. 2022

心のケアにたずさわる人が知っておきたい精神系のくすり : 薬からアプローチのしかたが見える! : 看護師&心理職・精神保健福祉士などメディカルスタッフに最適!
加藤, 隆弘
メディカ出版, Jan. 2022, 9784840475921, 188p, Japanese

メンタルヘルス・ファーストエイド : こころの応急処置マニュアルとその活用
Kitchener, Betty, Jorm, A. F., Kelly, Claire, 大塚, 耕太郎, 加藤, 隆弘, 小原, 圭司, メンタルヘルス・ファーストエイド・ジャパン
創元社, Jun. 2021, 9784422117614, 391p, Japanese

統合失調症における神経免疫とミクログリア 「統合失調症治療の新たなストラテジー」第2版　　　　　　　　　　　　　　　
加藤隆弘
先端医学社, Mar. 2021, [Contributor]

みんなのひきこもり : つながり時代の処世術
加藤, 隆弘
木立の文庫, Oct. 2020, 9784909862167, vii, 204p, Japanese

第15章 予防と早期介入（メンタル・ヘルスファーストエイド）「公認心理師の基礎と実践」シリーズ　　　　　　　　　　　　　　　
大塚耕太郎, 加藤隆弘
遠見書房, Jul. 2020, Japanese

第4章 気分症群〈気分障害〉「公認心理師の基礎と実践」シリーズ　　　　　　　　　　　　　　　
加藤隆弘
遠見書房, Jul. 2020, Japanese

コラム「バイオ・サイコ・ソーシャルモデル─脳科学と精神分析との融合モデルによる未来の精神医学」「公認心理師の基礎と実践」シリーズ　　　　　　　　　　　　　　　
加藤隆弘
遠見書房, Jul. 2020, Japanese, Scholarly book

第１章 精神医学の歴史的展望 「公認心理師の基礎と実践」シリーズ　　　　　　　　　　　　　　　
加藤 隆弘, 早川 宏平
遠見書房, Jul. 2020, Japanese, Scholarly book

若年者の抑うつ症－「現代抑うつ症候群」の提唱 〈講座 精神疾患の臨床〉　　　　　　　　　　　　　　　
加藤隆弘
中山書店, Jun. 2020, Japanese, Scholarly book, [Joint work]

〔Major achievements〕Developmental model of hikikomori: Possible ways to prevent and treat pathological social withdrawal in later life　　　　　　　　　　　　　　　
Takahiro A. Kato
Elsevier, San Diego, CA, USA, Nov. 2019, English

Urban mental health in the twenty-first century
Norman Sartorius, Naotaka Shinfuku, Heok Eee Kua, Takahiro A. Kato, Alan R. Teo, Masaru Tateno, Tae Young Choi, Yatan Pal Singh Balhara, Shigenobu Kanba
Springer International Publishing, Aug. 2018, English

Modulating microglial activation as a possible therapeutic target for depression
Mina Sato-Kasai, Takahiro A. Kato, Masahiro Ohgidani, Hideki Horikawa, Yoshito Mizoguchi, Akira Monji, Shigenobu Kanba
Springer Singapore, Jan. 2018, English

Understanding Depression : Volume 1. Biomedical and Neurobiological Background　　　　　　　　　　　　　　　
Sato-Kasai M, Kato TA, Ohgidani M, Horikawa H, Mizoguchi Y, Monji A, Kanba S, Modulating Microglial Activation As a Possible Therapeutic Target for Depression
Springer Singapore, Jan. 2018, 9789811065804, 322, 209-219, [Joint work]

Loneliness and single person households:Issues of kodoku-shi and hikikomori in Japan
Takahiro A. Kato, Naotaka Shinfuku, Norman Sartorius, Shigenobu Kanba
Springer Singapore, Mar. 2017, English

Minding Glial Cells in the Novel Understandings of Mental Illness　　　　　　　　　　　　　　　
Takahiro A. Kato, Aye M. Myint, Johann Steiner
Frontiers Media Lausanne, Feb. 2017, English

Loneliness and single person households: Issues of kodoku-shi and hikikomori in Japan. in Mental Health and Illness in the City　　　　　　　　　　　　　　　
Kato TA, Shinfuku N, Sartorius N, Kanba S
Springer Singapore, 2017, 9789811023255, 205-219, [Joint work]

Antidepressants modulate microglia beyond the neurotransmitters doctrine of mood disorders
Masahiro Ohgidani, Takahiro A. Kato, Yoshito Mizoguchi, Hideki Horikawa, Akira Monji, Shigenobu Kanba
Springer, New Delhi-India, Nov. 2016, English

Melatonin, Neuroprotective Agents and Antidepressant Therapy
Francisco López-Muñoz, Venkataramanujam Srinivasan, Domenico de Berardis, Cecilio Álamo, Takahiro A. Kato
Jun. 2016, Japanese

信頼生成の社会的基盤と生理的基盤. 第7章「社会関係資本の機能と創出－効率的な組織と社会(フロンティア実験社会科学4)」 (監修 西條辰義, 編集 清水和巳・磯辺剛彦)　　　　　　　　　　　　　　　
渡部 幹, 加藤 隆弘
勁草書房, Oct. 2015, Japanese

日本語臨床における「先生転移」の功罪―見るなの禁止の世界を超えて.「北山理論の発見――錯覚と脱錯覚を生きる」（監修 北山修, 編集 妙木浩之・池田政俊）　　　　　　　　　　　　　　　
加藤 隆弘
創元社, Oct. 2015, Japanese

北山理論の発見: 錯覚と脱錯覚を生きる
加藤隆弘, 北山 修, 日本語臨床における「先生転移」の功罪
創元社, Oct. 2015, 4422113054, 230, 71-91, [Joint work]

信頼生成の社会的基盤と生理的基盤.in フロンティア実験社会科学4　　　　　　　　　　　　　　　
渡部 幹, 加藤 隆弘
勁草書房, Oct. 2015, 9188, 133-166, [Joint work]

精神療法と薬物療法の併用の必要性と有効性. 《外来精神科診療プラクティス》シリーズパートＩ精神科臨床の知と技の新展開 2　　　　　　　　　　　　　　　
加藤 隆弘
中山書店, May 2015, Japanese

精神療法と薬物療法の併用の必要性と有効性.in メンタルクリニックでの薬物療法･身体療法の進め方　　　　　　　　　　　　　　　
加藤 隆弘
中山書店, May 2015, 9784521740010, 336, 219-229, [Joint work]

ディスチミア親和型うつ病. 南山堂医学大辞典 第20版　　　　　　　　　　　　　　　
加藤 隆弘
南山堂, Apr. 2015, Japanese

スプリッティング. 南山堂医学大辞典 第20版　　　　　　　　　　　　　　　
加藤 隆弘
南山堂, Apr. 2015, Japanese

南山堂医学大辞典
スプリッティング,ディスチミア親和型うつ病
南山堂, Mar. 2015, 9784525010805, 3100, 1313,1674-1675, [Contributor]

Histrionic Personality Disorder 演技性パーソナリティ障害 301.50(F60.4). 「DSM-5を読み解く－伝統的精神病理, DSM-IV, ICD-10をふまえた新時代の精神科診断」—第5巻 神経認知障害群／パーソナリティ障害群／性別違和／パラフィリア障害群／性機能不全　　　　　　　　　　　　　　　
加藤 隆弘
中山書店, Sep. 2014, Japanese

Neurodevelopmental and neuropsychiatric disorders
Akira Monji, Izumi Maezawa, Yoshito Mizoguchi, Takahiro A. Kato, Lee Way Jin
Springer New York, Jul. 2014, English, The etiology of neuropsychiatric disorders such as autism spectrum disorders (ASDs) and schizophrenia remains unclear. However, many aspects of their neuropathology were recently reported to be closely associated with microglial dysfunction. Microglia, which are the major players of innate immunity in the central nervous system, respond rapidly to pathological changes, even minor ones, and contribute directly to neuroinflammation by producing various cytokines and free radicals. Recent studies revealed that microglia become activated over the course of ASDs and schizophrenia, using brain neuroimaging and postmortem analyzes. Recent studies have also shown inhibitory effects of some antipsychotics on the release of inflammatory cytokines and free radicals from activated microglia, causing synaptic and white matter abnormalities as seen in ASDs and schizophrenia postmortem brains. In addition, recent evidence strongly suggests a neurodevelopmental role for microglia in regulating the formation/function of neuronal circuits by their phagocytic activity and structural interactions with synapses. In Rett syndrome (RTT) particularly, microglia become dysfunctional and neurotoxic, thus contributing to abnormal brain development. Populating the brain of RTT mice with wild-type microglia was also found to arrest the disease, indicating an essential role of microglia in regulating the neurodevelopmental trajectory. In summary, emerging evidence indicates that microglia are closely related to the progression and outcome of ASDs and schizophrenia. Understanding microglial pathology may shed new light on the most promising therapeutic strategies for ASDs and schizophrenia, among other neuropsychiatric disorders.

神経免疫によるレジリアンスの制御－脳内免疫細胞ミクログリアの観点から－. 第１部レジリアンスの精神病理学・脳科学・生物学, 「レジリアンス－症候学・脳科学・治療学－（八木 剛平・渡邊 衡一郎 編）」　　　　　　　　　　　　　　　
加藤 隆弘, 神庭 重信
金原出版株式会社, Jun. 2014, Japanese

レジリアンス 症候学・脳科学・治療学
加藤隆弘, 神庭重信, 八木剛平, 渡邊衡一郎, 神経免疫によるレジリアンスの制御－脳内免疫細胞ミクログリアの観点から－. 第１部レジリアンスの精神病理学・脳科学・生物学
金原出版, Jun. 2014, 9784307150699, 320, 56-65

The Intersection of Culture and Solitude: The Hikikomori Phenomenon in Japan
Alan R. Teo, Kyle W. Stufflebam, Takahiro A. Kato
Wiley-Blackwell, Dec. 2013, English

第一部 (メンタルヘルス総論)-第６章 精神医学にまつわる矛盾／アンチスティグマの精神医学－メンタルヘルスへの挑戦　　　　　　　　　　　　　　　
加藤 隆弘 訳(ノーマン・サルトリウス著/日本若手精神科医の会(JYPO)訳)
金剛出版, Feb. 2013, Japanese

第3章 精神病性障害／ 『専門家に相談する前のメンタルヘルス・ファーストエイド：こころの応急処置マニュアル 』　　　　　　　　　　　　　　　
加藤 隆弘, 橋本 直樹 訳 (B・キッチナー, A・ジョーム著/メンタルヘルス・ファーストエイド・ジャパン編訳)
創元社, Nov. 2012, Japanese

「精神分析（脳科学との接点）」／ 現代精神医学事典　　　　　　　　　　　　　　　
加藤 隆弘
弘文堂, Oct. 2011, Japanese

「ミクログリア」／ 現代精神医学事典　　　　　　　　　　　　　　　
加藤 隆弘
弘文堂, Oct. 2011, Japanese

現代精神医学事典
加藤 敏, 神庭 重信, 中谷 陽二, 武田 雅俊, 鹿島 晴雄, 狩野 力八郎, 市川 宏伸
弘文堂, 2011, 9784335651434, Japanese

「6. ミクログリアと精神疾患」. II. 分子生物学, B. 細胞『専門医のための精神科臨床リュミエール』16巻ー精神科医のための脳科学：これだけは知っておきたい基礎知識ー（神庭 重信・加藤 忠史編集）　　　　　　　　　　　　　　　
加藤 隆弘
中山書店, Jun. 2010, Japanese

ミクログリアと精神疾患. in 『専門医のための精神科臨床リュミエール16巻ー精神科医のための脳科学：これだけは知っておきたい基礎知識ー』（神庭重信・加藤忠史編集） pp178-179　　　　　　　　　　　　　　　
中山書店, 2010

脳科学エッセンシャル : 精神疾患の生物学的理解のために
神庭 重信, 加藤 忠史
中山書店, 2010, 9784521731308, Japanese

第２章V／南アジア／スリランカ[スリランカの精神保健医療]／ 『改訂 世界の精神保健医療』(新福尚隆・浅井邦彦編集)　　　　　　　　　　　　　　　
加藤 隆弘
へるす出版, Dec. 2009, Japanese

Lecture 10－うつ病の原因－／ 『「うつ」を見抜く！対処する！プライマリケア医のためのうつ病診療』(久保木富房, 坪井康次, 神庭重信編)　　　　　　　　　　　　　　　
加藤 隆弘, 門司 晃, 溝口 義人, 堀川 英喜, 神庭 重信
メジカルビュー社, Jul. 2009, Japanese

『先生転移』に潜む罪悪感の取り扱い／ 『罪の日本語臨床』(北山修、山下達久編集)　　　　　　　　　　　　　　　
加藤 隆弘
創元社, May 2009, Japanese

スリランカの精神保健医療. in『改訂 世界の精神保健医療』(新福尚隆・浅井邦彦編集) pp174-179　　　　　　　　　　　　　　　
へるす出版, 2009

『先生転移』に潜む罪悪感の取り扱い. in『罪の日本語臨床』(北山修・山下達久編) pp202-216　　　　　　　　　　　　　　　
創元社, 2009

プライマリケア医のためのうつ病診療 : 「うつ」を見抜く!対処する!
久保木 富房, 坪井 康次, 神庭 重信
メジカルビュー社, 2009, 9784758302364, Japanese

「摂食障害」『看護に役立つ疾患・症候事典—病態がわかる ケアがわかる—』（永井良三監修）　　　　　　　　　　　　　　　
加藤 隆弘
メヂカルフレンド社, Apr. 2008, Japanese

「先生」/ 日常臨床語辞典（妙木浩之編,北山修監修）　　　　　　　　　　　　　　　
加藤 隆弘
誠信書房, Sep. 2006, Japanese

「摂食障害」/ 米国精神医学会治療ガイドラインクイックリファレンス　　　　　　　　　　　　　　　
加藤 隆弘, 松尾 信一郎, 神庭 重信
医学書院, May 2006, Japanese

『先生』. in『日常臨床語辞典』（妙木浩之編,北山修監修）pp263-266　　　　　　　　　　　　　　　
誠信書房, 2006

精神疾患とその治療.in『こころの科学』増刊『公認心理師入門―知識と技術』　　　　　　　　　　　　　　　
加藤 隆弘
日本評論社, 9784535904460, 175, 92-95

国際学会にジャパニーズ英語で参加する意義：言葉の困難から患者の苦悩に思いを馳せる　　　　　　　　　　　　　　　
加藤 隆弘
BPCNPNP2025合同年会, 14 Nov. 2025

iMG (induced microglia-like) 細胞を用いた抗うつ薬Escitalopramのミクログリアに与える影響の評価　　　　　　　　　　　　　　　
日吉恵都, 久良木聡太, 稲嶺翔吾, 扇谷昌宏, 松島敏夫, 中尾智博, 加藤隆弘
BPCNPNP2025合同年会, 13 Nov. 2025

双極性障害患者由来 induced microglia-like cells (iMG 細胞)を用いたトランスクリプトーム解析（ポスター）　　　　　　　　　　　　　　　
久良木聡太, 稲嶺翔吾, 扇谷昌宏, 松島敏夫, 中尾智博, 加藤隆弘
BPCNPNP2025合同年会, 13 Nov. 2025

うつ病の個別化医療実現のために：生物心理社会的理解による多軸的な評価と治療　　　　　　　　　　　　　　　
加藤 隆弘
BPCNPNP2025合同年会 ランチョンセミナー, 13 Nov. 2025

How to Rescue Sufferers with Hikikomori in the Digital Urbanized Society　　　　　　　　　　　　　　　
Kato TA
the 2025 Annual Congress of the Taiwanese Society of Psychiatry, 08 Nov. 2025

iMG (induced microglia-like) 細胞を用いた抗うつ薬Escitalopramのミクログリアに与える影響の評価（ポスター）　　　　　　　　　　　　　　　
日吉恵都, 久良木聡太, 稲嶺翔吾, 扇谷昌宏, 松島敏夫, 中尾智博, 加藤隆弘
第98回日本生化学会大会, 05 Nov. 2025

「生きづらさ尺度」の開発②：数値化しづらい精神分析的精神療法の効果計測のために　　　　　　　　　　　　　　　
久保太聖, 香月亮子, 舛田亮太, 小田可奈子, 加藤隆弘
日本精神分析学会第71回大会, 02 Nov. 2025

CO-EXISTING PATHOLOGICAL AND NON-PATHOLOGICAL HIKIKOMORI IN URBAN DIGITALIZED SOCIETY: INTRODUCING NOVEL SCREENING METHODS　　　　　　　　　　　　　　　
Kato TA
The WCP 2025, 06 Oct. 2025, Poster presentation

Modern-type Depression: the case of Japan. SIMPOSIUM 13 – From Depression to Depressions: which are the new social determinants?　　　　　　　　　　　　　　　
Kato TA
14th SIPS National Congress, 03 Oct. 2025

Social withdrawal and Hikikomori: next on psychopathology agenda? How to Evaluate and Treat Hikikomori in the Digitalized Society　　　　　　　　　　　　　　　
Kato TA
14th SIPS National Congress, 02 Oct. 2025

Current Topic of Biological Psychiatry: Synapse, Glia and Inflammation　　　　　　　　　　　　　　　
Kato TA
PRCP and WACP Tokyo 2025, 27 Sep. 2025

How to Assess and Intervene Hikikomori in the 21st Digitalized Society　　　　　　　　　　　　　　　
Kato TA
PRCP and WACP Tokyo 2025, 27 Sep. 2025

恒常性破綻の病態解明のための患者血液単球由来iMG細胞を用いたリバーストランスレーショナル研究　　　　　　　　　　　　　　　
加藤隆弘
第68回日本神経化学会大会, 12 Sep. 2025

Hikikomori and Groups: Clinical Groups for Hikikomori and Theater Groups by Individuals with Mental Disorders　　　　　　　　　　　　　　　
Kato TA
IAGP 2025, 23 Aug. 2025

Multilayered supports for hikikomori with real and virtual reality world　　　　　　　　　　　　　　　
Kato TA
IAGP 2025, 22 Aug. 2025

ネット社会・デジタル社会は「ひきこもり」を作るのか、救うのか？　　　　　　　　　　　　　　　
加藤隆弘
思春期青年期精神医学会第37回大会, 06 Jul. 2025

支援困難な「社会的ひきこもり」におけるメタバースやVR活用による支援力向上プロジェクト　　　　　　　　　　　　　　　
加藤 隆弘
第121回日本精神神経学会学術総会, 20 Jun. 2025

「病的ひきこもり」と「非病的ひきこもり」を評価可能なHiDE-Sによる早期支援の提案　　　　　　　　　　　　　　　
加藤 隆弘
第121回日本精神神経学会学術総会, 20 Jun. 2025

心を揺さぶられるアート（症例）から始まる精神分析のエビデンス創出：エビデンス・コンプレッ クスの打開　　　　　　　　　　　　　　　
加藤 隆弘
第121回日本精神神経学会学術総会, 20 Jun. 2025

成人発達障害症例へのDSM/ICDでの「分ける（わかる）」臨床と「分けない（わからない）」精神 分析的臨床　　　　　　　　　　　　　　　
加藤 隆弘
第121回日本精神神経学会学術総会, 20 Jun. 2025

フロイトの無意識的欲動と脳内免疫細胞：ミクログリアは「死の欲動」を司る？　　　　　　　　　　　　　　　
加藤 隆弘
第121回日本精神神経学会学術総会, 19 Jun. 2025

慢性疼痛と新型／現代型うつ　　　　　　　　　　　　　　　
加藤 隆弘, 藤本 晃嗣, 細井 昌子
第121回日本精神神経学会学術総会, 19 Jun. 2025

抑うつ評価に関するロボット面接研究から考える先生転移・先生逆転移：転移から解放される未来 の精神医療　　　　　　　　　　　　　　　
加藤 隆弘
第121回日本精神神経学会学術総会, 19 Jun. 2025

Current Trend of the Patterns of Antidepressants in Asian Countries: Evidence from REAP-AD3　　　　　　　　　　　　　　　
Kato TA
CINP-AsCNP 2025, 16 Jun. 2025

Exploring Asian Neuropsychopharmacological Research: Polypharmacy, Microglia, and Hikikomori Beyond Western Perspectives　　　　　　　　　　　　　　　
Kato TA
CINP-AsCNP 2025 (Award Lecture), 15 Jun. 2025

死の欲動と脳内免疫細胞ミクログリア：精神分析と脳科学との接点　　　　　　　　　　　　　　　
加藤 隆弘
日本精神分析協会 第43回学術大会, 08 Jun. 2025

Hikikomori, pathological social withdrawal and modern type depression: Assessment, intervention and novel therapeutic approach using digital technologies　　　　　　　　　　　　　　　
Kato TA
EPA2025, 05 Apr. 2025, English

からだと集団精神療法－精神分析、メンタライゼーション、身体心理療法の出会い－　　　　　　　　　　　　　　　
加藤 隆弘(企画者)
日本集団精神療法学会 第42回学術大会 自主企画 ワークショップⅨ, 23 Mar. 2025

学校〇グループｰグループが生まれるとき－　　　　　　　　　　　　　　　
加藤 隆弘(企画者)
日本集団精神療法学会 第42回学術大会 自主企画 ワークショップⅣ, 22 Mar. 2025

患者血液単球由来iMG細胞を用いたリバーストランスレーショナル研究　　　　　　　　　　　　　　　
加藤隆弘
APPW2025 シンポジウム:時間分解能を高めた疾患特異的分化細胞間統合解析とアンバイアスドリバーストランスレーショナルリサーチ, 17 Mar. 2025

DSM-5TR時代の「ひきこもり」：精神医学における位置付けと支援を多元モデルで考える　　　　　　　　　　　　　　　
加藤隆弘
第43回日本社会精神医学会 教育講演, 13 Mar. 2025, Public discourse

Difficult-to-Reach 患者の早期支援実現に向けたロボット・VR・メタバースの活用：アンチスティグマの観点から　　　　　　　　　　　　　　　
加藤隆弘
第43回日本社会精神医学会 シンポジウム3 デジタル技術と精神医学の共生, 13 Mar. 2025

Why We Need to Write/Publish Academic/Scientific Papers in Psychiatry: From a Hikikomori-like Student to a Hikikomori Researcher　　　　　　　　　　　　　　　
Kato TA
The 22nd CADP, 09 Feb. 2025

ヒト血液を用いた脳内ミクログリア活動性予測による心のリバース・トランスレーショナル研究　　　　　　　　　　　　　　　
加藤隆弘
第1回IC2NEMO, 28 Jan. 2025

How to Rescue Sufferers with Hikikomori in the Digital Urbanized Society　　　　　　　　　　　　　　　
Kato TA
5th Webinar Workshop- WPA Section on “Urban Mental Health” : Mental Health Challenges in the Digital Urbanized Society: Internet Gaming Disorder, Modern-Type Depression, Personality Formation and Hikikomori, 20 Jan. 2025

患者のミクログリア活性化を血液で予測する：サロゲートマーカーとしてのヒト単球由来iMG細胞 精神疾患ミクログリア仮説解明のための血液を用いたリバース・トランスレーショナル研究：：ヒト単球由来iMG細胞作製とメタボローム解析　　　　　　　　　　　　　　　
加藤隆弘
第28回 グリア研究会, 07 Dec. 2024

The Role Social Withdrawal Syndrome (Known as "Hikikomori") in Mental Disorders　　　　　　　　　　　　　　　
Kato TA
The 10th WCAP, 06 Dec. 2024

HIKIKOMORI – Pathological Social Withdrawal: How to Ditect, Evaluate and Intervene　　　　　　　　　　　　　　　
Kato TA
REAP-WCAP PRE-CONGRESS 2024, 04 Dec. 2024

Social isolation and hikikomori in ageing society　　　　　　　　　　　　　　　
Kato TA
2024 Asia-Pacific Psychiatry and Aging Conference, 30 Nov. 2024

How to Rescue Sufferers with Hikikomori in the Digital Urbanized Society　　　　　　　　　　　　　　　
Kato TA
Symposium of "Mental Health Challenges in the Digital Urbanized Society: Internet Gaming Disorder, Modern-Type Depression and Hikikomori" , 24Th World Congress of Psychiatry, 17 Nov. 2024

ヒトの意思決定を脳内免疫細胞ミクログリアが司る？健常者の信頼行動からひきこもり・自殺まで　　　　　　　　　　　　　　　
加藤 隆弘
大阪大学蛋白質研究所セミナー：意思決定の分子・回路・計算機構, 11 Nov. 2024

ひきこもりの精神分析的臨床と定量的研究の二足の草鞋　　　　　　　　　　　　　　　
加藤 隆弘
日本精神分析学会第７０回大会 ランチョンセミナー, 09 Nov. 2024

ヒト血液由来ミクログリア様（iMG）細胞を用いたリバース・トランスレーショナル研究：精神疾患からストレス関連疾患まで　　　　　　　　　　　　　　　
加藤 隆弘
心身医学のニューロサイエンス研究会, 03 Nov. 2024

血液メンタルストレスチェックで心の不調を「見える化」する　　　　　　　　　　　　　　　
加藤隆弘, 瀬戸山大樹, 福應温
2024純真学園祭-学術研究講演会「メンタルヘルスの不調を測る新しい検査法」, 19 Oct. 2024

Novel Concepts of Hikikomori: Pathological and Happy Hikikomori　　　　　　　　　　　　　　　
Kato TA
The First France - Japan Hikikomori Research Workshop, 16 Oct. 2024

フロイトの無意識的欲動と精神分析プロセスーニューラルネットワーク・ミクログリア・ロボット　　　　　　　　　　　　　　　
加藤隆弘
小寺記念精神分析研究財団主催 学際的ワークショップ 『精神分析の知のリンクにむけて』 第九回「意識、無意識、AI」, 14 Oct. 2024

患者血液由来ミクログリア様（iMG）細胞を用いたリバース・トランスレーショナル研究：疼痛・精神疾患・ストレス関連疾患の力動的理解に基づく未来の薬物療法　　　　　　　　　　　　　　　
加藤隆弘
第151回薬理学会関東部会 シンポジウム：ストレスによる疾患表現変容と精神病態段階的薬物治療, 12 Oct. 2024

Modern-Type Depression and Hikikomori: Mental Health of the YEA (15-25 year old) in Japan.　　　　　　　　　　　　　　　
Kato TA
2024 NUS Mind Science Centre Round Table Discussion on Youth and Emerging Adults: Navigating Mental Health Challenges, National Unversity of Singapore (NUS), 11 Oct. 2024

対象喪失論　　　　　　　　　　　　　　　
加藤隆弘
日本精神分析協会 精神分析インスティテュート福岡支部主催 2024年度精神分析セミナー 第 3 回「フロイトの精神病理学」, 22 Sep. 2024

ひきこもりの精神分析ー臨床と研究アプローチ　　　　　　　　　　　　　　　
加藤隆弘
北海道精神分析研究会, 15 Sep. 2024

Hikikomori in the World　　　　　　　　　　　　　　　
Kato TA
The 2nd Joint Seminar of Korea-Japan Psychiatric Disease(The Korea-Japan Young Psychiatrists’ Conference), 07 Sep. 2024

精神神経疾患の生物学的解析　　　　　　　　　　　　　　　
加藤隆弘
星薬科大学薬理学研究室セミナー, 19 Aug. 2024

双極性障害患者由来induced microglia-like cells (iMG細胞)を用いたRNA sequence解析　　　　　　　　　　　　　　　
久良木聡太, 稲嶺翔吾, 扇谷昌宏, 松島敏夫, 加藤隆弘
NEURO 2024, 26 Jul. 2024

社交不安を伴うひきこもり当事者への古典的な週4回カウチの精神分析:「死の欲動（Death Drive）」を運転すること　　　　　　　　　　　　　　　
加藤隆弘
2024年度 日本不安症学会／日本認知療法・認知行動療法学会 シンポジウム：社交不安を伴うひきこもりへの多様な支援：古典的精神分析から最新の認知行動療法・メタバース・VRまで, 19 Jul. 2024

社交不安を伴うひきこもり当事者と家族への新しい支援：メタバースとVRの活用　　　　　　　　　　　　　　　
久保太聖, 浅海久美子, 佐藤郁, 松島敏夫, 平河則明, 三淵啓自, 林裕子, 中尾智博, 浅海道子, 加藤隆弘
2024年度 日本不安症学会／日本認知療法・認知行動療法学会 シンポジウム：社交不安を伴うひきこもりへの多様な支援：古典的精神分析から最新の認知行動療法・メタバース・VRまで, 19 Jul. 2024

社会的ひきこもりの逆境体験・新型／現代型うつ・ゲーム障害との相関理解による新たな予防・治療戦略　　　　　　　　　　　　　　　
加藤隆弘
第21回日本うつ病学会総会 自殺対策委員会企画シンポジウム「孤独・孤立と自殺：その予防の可能性を探る」, 13 Jul. 2024

社会的ひきこもりに対するメタバース・ＶＲによる支援法の開発　　　　　　　　　　　　　　　
加藤隆弘, 浅海久美子, 久保 太聖, 松島 敏夫, 三淵 啓自, 林 裕子, 浅海 道子
第120回日本精神神経学会学術総会 シンポジウム:現実空間と精神医学：不登校・ひきこもり支援にメタバースをどう活かすか, 22 Jun. 2024

グループ嫌いが集団精神療法（ 「体験グループ」 ）に出会ったら：臨床家そして研究者としての礎の体得　　　　　　　　　　　　　　　
加藤隆弘
第120回日本精神神経学会学術総会 一般シンポジウム 71: 集団精神療法と出会うにはー教育と研修, そして実践へ, 21 Jun. 2024

日本の精神分析の未来―エディプス神話からエヴィデンス神話を読み解く.　　　　　　　　　　　　　　　
加藤隆弘
第120回日本精神神経学会学術総会 一般シンポジウム 65:日本における精神療法：受容と展開, 21 Jun. 2024

社会的ひきこもりとゲーム・ネット依存：悪循環への理解と打開策の提案.　　　　　　　　　　　　　　　
加藤隆弘, 久保太聖, 松尾敬太朗, 松島敏夫, 館農勝
第120回日本精神神経学会学術総会 シンポジウム :日常診療でゲーム・ネット依存に対応するために, 21 Jun. 2024

ロボット面接導入により転移・逆転移から解放される未来の精神医療.　　　　　　　　　　　　　　　
加藤隆弘, 松島 敏夫, 松尾 敬太朗, 吉川 雄一郎, 熊﨑 博一
第120回日本精神神経学会学術総会 シンポジウム: 精神科医療においてロボットがこれから治療場面で果たしていく役割, 20 Jun. 2024

Hikikomori: Psychopathological and Biological Understanding of Socially Isolated Persons.　　　　　　　　　　　　　　　
Kato TA
WSFBP 2024 Symposium "Social Isolation in youths: Prevention and Treatment Strategies", 06 Jun. 2024

脳内免疫細胞ミクログリアから考える脳とこころの若返り：ヒト血液由来iMG細胞によるリバーストランスレーショナル研究.　　　　　　　　　　　　　　　
加藤隆弘
第24回日本抗加齢医学会総会 シンポジウム7 :若い感覚をキープする, 31 May 2024

Clarifying the microglia hypothesis of mood disorders using human blood-induced microglia-like (iMG) cells.　　　　　　　　　　　　　　　
Kato TA
The 35th World Congress of Neuropsychopharmacology (CINP 2024),AsCNP Symposium : Neuroinflamation Mechanisms and Treatment Targets for Depriession, 26 May 2024

ヒト血液由来ミクログリア様（iMG）細胞によるサイコ・グリア・アナリシス研究：ミクログリアは無意識的欲動の正体か？　　　　　　　　　　　　　　　
加藤隆弘
第54回日本神経精神薬理学会 / 第34回日本臨床精神神経薬理学会合同年会JSNP/JSCNP joint meeting, 25 May 2024

遅発性ジスキネジアは精神医療現場でなぜ見て見ぬふりされていたのか？医療者としての心構えを国内外のデータベース研究から学ぶ.　　　　　　　　　　　　　　　
加藤隆弘
第54回日本神経精神薬理学会 / 第34回日本臨床精神神経薬理学会合同年会JSNP/JSCNP joint meeting, 24 May 2024

Hikikomori and Death Drive: Who Drive My Car?　　　　　　　　　　　　　　　
Kato TA
IPA Asia Pacific Conference Sydney 2024 Symposium: Hikikomori (Pathological Social Withdrawal): Understanding the Japan-rooted Globalizing Psychopathol,, 02 May 2024

Hikikomori, pathological social withdrawal and modern type depression: assessment, intervention and novel therapeutic approach using digital technologies　　　　　　　　　　　　　　　
Kato TA
EPA2024, 06 Apr. 2024

社会的ひきこもりの支援におけるメタバースやＶＲといった仮想空間の活用　　　　　　　　　　　　　　　
加藤隆弘, 浅海久美子, 久保太聖, 松島敏夫, 三淵啓自, 林裕子, 浅海道子
第42回日本社会精神医学会 シンポジウム「仮想空間は精神医学を変えるのか?」, 14 Mar. 2024

ヒト血液由来直接誘導ミクログリア様(iMG)細胞―ヒトiMG細胞の開発とその脳疾患研究への応用―　　　　　　　　　　　　　　　
加藤隆弘
九大医療健康ユニットシンポジウム, 02 Mar. 2024

Hikikomori and Modern-Type Depression in Japan　　　　　　　　　　　　　　　
Kato TA
2024 Joint Seminar of Korea-Japan Hikikomori & Modern-type Depression (JSPS-NRF Joint Research Foundation), 23 Feb. 2024

ひきこもりの多面的理解と多層的な支援　　　　　　　　　　　　　　　
加藤隆弘
長崎大学精神医学教室主催オンラインセミナー, 07 Feb. 2024

患者血液由来ミクログリア様（iMG）細胞による精神疾患リバース・トランスレーショナル研究　　　　　　　　　　　　　　　
加藤隆弘
第8回日本骨免疫学会 ウィンターセミナー, 01 Feb. 2024

社会的ひきこもりの多軸的理解に基づく多面的アプローチ：薬物療法から精神分析・メタバースまで　　　　　　　　　　　　　　　
加藤隆弘
熊本大学精神科特別セミナー, 26 Jan. 2024

ヒト血液単球由来誘導ミクログリア様（iMG）細胞を用いた精神神経疾患の病態解明: リバーストランスレーショナル研究　　　　　　　　　　　　　　　
加藤隆弘
日本薬理学会第97回年会 シンポジウム: ヒト疾患由来細胞解析とゲノム編集技術を応用したリバーストランスレーショナルニューロサイエンス研究の新潮流, 14 Dec. 2023

Hikikomori & Psychoanalysis　　　　　　　　　　　　　　　
Kato TA
2nd IPA-COCAP (Committee for Child and Adolescent Psychoanalysis of International Psychoanalytical Association) Conference, 19 Nov. 2023

Teacher (SENSEI) Transference, Amae and Hikikomori based on Kawanoji Culture in Japan　　　　　　　　　　　　　　　
Kato TA
East Asian Academy of Cultural Psychiatry (EAACP) Symposium 2023 "Psychotherapy and Culture", 18 Nov. 2023

ひきこもりの多面的理解と多層的な支援ーくすりからメタバースまで　　　　　　　　　　　　　　　
加藤隆弘
第63回中国・四国精神神経学会・第46回中国・四国精神保健学会 ランチョンセミナー, 11 Nov. 2023

気分変調にミクログリアの複雑な活性化は関与するのか？患者血液を用いたリバーストランスレーショナル研究　　　　　　　　　　　　　　　
加藤隆弘
第45回日本生物学的精神医学会年会 シンポジウム10: うつ病, その病態の複雑系: overlap/difference/interaction, 07 Nov. 2023

病的ひきこもり(pathological social withdrawal)の診断評価システム: 生物学的理解のため　　　　　　　　　　　　　　　
加藤隆弘
第45回日本生物学的精神医学会年会 シンポジウム4: ひきこもりを生物学的に理解する:臨床・基礎・理論の融合, 07 Nov. 2023

「社会的ひきこもり」の新たな精神医学的位置付けと治療的アプローチ　　　　　　　　　　　　　　　
加藤隆弘
第45回日本生物学的精神医学会年会 ランチョンセミナー, 07 Nov. 2023, Public discourse

うつ病の個別化医療実現のための生物学と精神病理学との融合による多軸的評価支援システム　　　　　　　　　　　　　　　
加藤隆弘
第45回日本生物学的精神医学会年会 ランチョンセミナー, 06 Nov. 2023, Public discourse

Reverse-Translational Research using Human Blood induced Microglia-like (iMG) Cells for Mental Disorders ヒト血液由来ミクログリア様（iMG）細胞を用いた精神疾患に対するリバーストランスレーショナル研究　　　　　　　　　　　　　　　
加藤隆弘
第96回日本生化学会大会 シンポジウム: グリア多様性の理解に基づく精神・神経変性疾患の機序解明と治療法開発, 31 Oct. 2023

Impact of rational polypharmacy based on the REAP-case vignette survey　　　　　　　　　　　　　　　
Kato TA
The 23rd WPA World Congress of Psychiatry, 30 Sep. 2023

Hikikomori and Digital Technopathies　　　　　　　　　　　　　　　
Kato TA
The 23rd Korea Japan Young Psychiatrists’ Conference Korea-Japan Young Psychiatrists’ Academy,, 22 Sep. 2023

ひきこもりの精神分析　　　　　　　　　　　　　　　
加藤隆弘
日本精神分析協会 精神分析インスティテュート福岡支部主催 2023年度精神分析セミナー第 3 回「パーソナリティの病理」, 17 Sep. 2023

「新型／現代型うつ」の生物心理社会精神医学的考察ー精神病理学診断と DSM診断との対立を超えて　　　　　　　　　　　　　　　
日本心理学会第87回大会, 15 Sep. 2023

社会的ひきこもりの精神医学的位置付けとその生物学的病態解明.　　　　　　　　　　　　　　　
加藤隆弘
第53回日本神経精神薬理学会年会 シンポジウム15: ひきこもりの意思決定の基礎・臨床・理論によるトランスレーショナルリサーチ, 08 Sep. 2023

気分障害のミクログリア病態治療仮説: リバーストランスレーショナル研究　　　　　　　　　　　　　　　
加藤隆弘
第53回日本神経精神薬理学会年会 シンポジウム5: 新しいうつ病の病態仮説Beyond monoamines: 創薬を見据えて, 07 Sep. 2023

ADHDライク症例に精神分析的治療は有効か？「はみ出し人間」から「枠あり人間」へ　　　　　　　　　　　　　　　
加藤隆弘
日本精神分析的精神医学会第21回大会 シンポジウム ADHDの精神分析, 27 Aug. 2023

「新型／現代型うつ病ーひきこもり」スパイラルに注目した社会的ひきこもりの治療戦略　　　　　　　　　　　　　　　
加藤隆弘
富山県臨床精神神経医学研究会, 18 Aug. 2023

うつ病の精神病理学と生物学の相補的理解による先端医療実現のために　　　　　　　　　　　　　　　
加藤隆弘
2023年度星薬科大学薬理学研究室卒論研修(特別講演), 30 Jul. 2023, Public discourse

ヒト血液由来ミクログリア様（iMG）細胞を用いた脳とこころの病態解明研究　　　　　　　　　　　　　　　
加藤隆弘
福島医科大学医学研究科特別講義, 28 Jul. 2023

精神病理学と生物学の融合によりうつ病を再構築する: 未来の個別化医療の実現に向けて　　　　　　　　　　　　　　　
加藤隆弘
第20回日本うつ病学会総会 共催シンポジウム, 21 Jul. 2023

ひきこもりの力動的臨床　　　　　　　　　　　　　　　
加藤隆弘
名古屋大学医学部付属病院主催 2023年度名古屋精神分析セミナー, 09 Jul. 2023, Public discourse

社会的ひきこもりの臨床と基礎の橋渡しによるバイオマーカー創出と支援法の開発　　　　　　　　　　　　　　　
加藤隆弘
第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会 合同大会合同シンポジウム Exploration of novel molecular therapeutic target on neuropsychiatric disorders 神経精神疾患の克服に向けた新たな分子治療標的の探索, 08 Jul. 2023

ヒト血液単球由来iMG細胞を用いたリバーストランスレーショナル研究: 患者のミクログリア活性化をin vitroで予測する　　　　　　　　　　　　　　　
加藤隆弘
第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会合同大会 合同シンポジウム 神経炎症・免疫・病理から俯瞰する精神・神経疾患研究, 07 Jul. 2023

抑うつ症候群の一亜型としての社会的ひきこもりとその治療的アプローチ　　　　　　　　　　　　　　　
加藤隆弘
広島県精神神経科診療所協会学術講演会, 06 Jul. 2023

「新型／現代型うつ病ーひきこもり」スペクトラム理論による社会的ひきこもりの治療戦略　　　　　　　　　　　　　　　
加藤隆弘
CNS voice seminar in Oita, 04 Jul. 2023

炎症免疫細胞ミクログリアから考える臨床ストレス科学: 痛みからうつ病まで　　　　　　　　　　　　　　　
加藤隆弘
第64回日本心身医学会総会, 02 Jul. 2023

「新型/現代型うつ」は双極Ⅱ型障害か？－現代型抑うつ症候群への抗精神病薬の可能性－.　　　　　　　　　　　　　　　
加藤隆弘
双極性障害Webセミナー, 28 Jun. 2023

社会的ひきこもりとゲーム障害における鶏卵問題とその打開策の提案　　　　　　　　　　　　　　　
加藤隆弘
第119回日本精神神経学会学術 シンポジウム81: ゲーム障害の予防・治療について, 24 Jun. 2023

ひきこもりと集団精神療法母校的居場所の中で「ひきこもる能力」を獲得すること　　　　　　　　　　　　　　　
加藤隆弘
第119回日本精神神経学会学術総会 シンポジウム50: いまなぜグループか？新しいつながり時代の集団精神療法, 23 Jun. 2023

慢性疼痛と新型/現代型うつ　　　　　　　　　　　　　　　
加藤隆弘
第119回日本精神神経学会学術総会 シンポジウム18: 慢性疼痛, 22 Jun. 2023

ひきこもり早期支援のためのコミュニケーションロボットによる診断評価法の開発　　　　　　　　　　　　　　　
加藤隆弘
第119回日本精神神経学会学術総会 シンポジウム13: 精神疾患におけるヒューマノイドロボットを用いた支援の現状と今後の課題,, 22 Jun. 2023

フロイト精神分析における治癒像: 「死の欲動」を抱えること　　　　　　　　　　　　　　　
加藤隆弘
第119回日本精神神経学会学術総会 シンポジウム５：精神療法と治癒像, 22 Jun. 2023

抑うつ症状に着目した社会的ひきこもりの多面的評価と治療　　　　　　　　　　　　　　　
加藤隆弘
セミナー「全人医療の明日を切り開く～心身不調とひきこもり～」, 02 Jun. 2023

Intervention for school refusal and hikikomori, severe social withdrawal, using robots and Metaverse　　　　　　　　　　　　　　　
Kato TA
ASCAPAP 2023, 28 May 2023

Hikikomori, pathological social withdrawal and modern type depression: assessment, intervention and novel therapeutic approach using digital technologies　　　　　　　　　　　　　　　
Kato TA, Umberto Volpe
EPA 2023, 25 Mar. 2023

引き継いだひきこもりグループにおける初学者のグループ体験－主体性の獲得に着目して　　　　　　　　　　　　　　　
堀江和正, 加藤隆弘
一般社団法人 日本集団精神療法学会第40回学術大会, 19 Mar. 2023

アバターやコミュニケーションロボットはひきこもり支援に有用か？　　　　　　　　　　　　　　　
加藤隆弘
第41回日本社会精神医学会 シンポジウム6：ひきこもりの現在の状況と今後の支援のあり方を検討する, 16 Mar. 2023

慢性疼痛の病態解明のための心身医学と精神医学との連携：うつ病とミクログリアに着目して　　　　　　　　　　　　　　　
加藤隆弘
第52回日本慢性疼痛学会, 10 Mar. 2023

ひきこもりの多面的理解に基づく具体的な支援アプローチ　　　　　　　　　　　　　　　
加藤隆弘
大分大学医学部精神神経医学講座セミナー, 02 Mar. 2023

「見るなの禁止」に覆い隠された「甘え」：「先生逆転移」の観点から.　　　　　　　　　　　　　　　
加藤隆弘
現代精神分析研究会 シンポジウム「見るなの禁止と巻き込まれ型原光景」, 26 Feb. 2023

ひきこもりの多面的理解に基づく具体的な支援アプローチ（　　　　　　　　　　　　　　　
加藤隆弘
第20回浜松医大精神医学・児童精神医学オンライン講座：「ひきこもりと不登校」, 23 Feb. 2023

Reverse-Translational Research to Clarify the psychodynamic roles of microglia in Physical and Mental Disorders　　　　　　　　　　　　　　　
加藤隆弘
第9回Neuroscience Network in Kobeシンポジウム, 17 Feb. 2023

ひきこもりと自閉スペクトラム症　　　　　　　　　　　　　　　
加藤隆弘
第15回自閉症学研究会, 28 Jan. 2023

「精神系のくすり」をわかりやすく学ぼう！～薬物療法と心理療法のマリアージュ～　　　　　　　　　　　　　　　
加藤隆弘
メディカ出版主催こころJOBスキルアップセミナー, 14 Jan. 2023

Psychoanalysis of a Woman with Hikikomori (Pathological Social Withdrawal): Knowing and Feeling the Sense of Loneliness　　　　　　　　　　　　　　　
Kato TA
IPA Asia-Pacific Conference 2023, 05 Jan. 2023

末梢の免疫細胞で脳とこころの闇を『見える化』する. ヒト血液由来ミクログリア様（iMG）細胞による臨床と基礎の橋渡し　　　　　　　　　　　　　　　
加藤隆弘
文部科学省科学研究費助成事業 令和3年度発足 学術変革領域(B) 脳分子探査 第2回オンラインセミナー, 14 Dec. 2022

Establishing the reverse-translational research system to clarify the dynamic roles of human microglia:From minocycline RCT trial to blood -induced microglia-like (iMG) cells　　　　　　　　　　　　　　　
加藤隆弘
第26回グリア研究会（The 26th Annual Meeting of the Japan Glia), 03 Dec. 2022

ヒト血液由来直接誘導ミクログリア様(iMG)細胞による精神疾患リバーストランスレーショナル研究　　　　　　　　　　　　　　　
加藤隆弘
BPCNPNPPP4学会合同年会, シンポジウム6 精神・神経疾患における脳抹消連関研究, 04 Nov. 2022

メンタルヘルス領域における血液メタボローム解析による「こころの不調」の早期発見　　　　　　　　　　　　　　　
加藤隆弘
BPCNPNPPP4学会合同年会, シンポジウム1 精神疾患とオミックス研究最前線, 04 Nov. 2022

精神疾患患者の血液解析（単球由来ミクログリア様細胞・メタボローム解析）によるリバーストランスレーショナル研究　　　　　　　　　　　　　　　
加藤隆弘
慶應義塾大学医学部精神神経科学教室 精神薬理学研究室主催 Web講演会, 07 Oct. 2022

ヒト血液由来ミクログリア様（iMG）細胞を用いた精神疾患モデル細胞研究　　　　　　　　　　　　　　　
加藤隆弘
国立精神・神経医療研究センター 精神保健研究所 精神疾患病態研究部主催 第6回精神病態セミナー, 16 Sep. 2022

ヒト血液由来直接誘導ミクログリア様(iMG)細胞 iMG 細胞の開発とその脳疾患 研究への応用　　　　　　　　　　　　　　　
加藤隆弘
AMED 精神・神経疾患メカニズム解明プロジェクト 第1回分科会, 19 Aug. 2022

ひきこもり研究外来から考えるひきこもり本人・家族へのアプローチ-ひきこもる能力を育む居場所づくり- (指定討論)　　　　　　　　　　　　　　　
加藤隆弘
日本カウンセリング学会第54回web大会 自主企画シンポジウム「ひきこもり状態における心理社会的実践と個人差要因」, 06 Aug. 2022
06 Aug. 2022 - 07 Aug. 2022

それぞれの思い描く日常生活を取り戻すために(パネルディスカッション）　　　　　　　　　　　　　　　
加藤隆弘
第19回日本うつ病学会総会 第5回日本うつ病リワーク協会年次大会／第24回JDC市民公開講座, 17 Jul. 2022

身近な人の「こころの不調サイン」に気付いたら？～メンタルヘルス・ファーストエイドの紹介～　　　　　　　　　　　　　　　
加藤隆弘
第19回日本うつ病学会総会, 17 Jul. 2022

うつ病のミクログリア仮説～抗炎症作用を目的とした栄養療法の可能性～　　　　　　　　　　　　　　　
加藤隆弘
第19回日本うつ病学会総会, 15 Jul. 2022

ナルシシズムの脳科学　　　　　　　　　　　　　　　
加藤隆弘
思春期青年期精神医学会第34回大会, ワークショップ「ナルシシズムを科学する」, 10 Jul. 2022

ヒト血液由来ミクログリア様（iMG）細胞による身体の痛みとこころの痛みのトランスレーション　　　　　　　　　　　　　　　
加藤隆弘
一般社団法人日本ペインクリニック学会第56回学術集会, シンポジウム10痛みの基礎研究成果の臨床実践：痛みによる難治性基礎疾患の負の修飾からボーダレスな統合的疾患治療の必要性を考える, 09 Jul. 2022

Blood biomarkers of hikikomori: Development of support system for hikikomori based on findings from the hikikomori-research clinic.　　　　　　　　　　　　　　　
加藤隆弘, 瀬戸山大樹, 松島敏夫, 康東天
NEURO2022 シンポジウム：社会的ひきこもり（hikikomori）における意思決定の回路・計算・臨床, 30 Jun. 2022

うつ病・ひきこもり患者の血液メタボローム解析による「こころの不調」の早期発見　　　　　　　　　　　　　　　
加藤隆弘, 瀬戸山大樹, 松島敏夫, 康東天
第70回質量分析総合討論会, 24 Jun. 2022

コミュニケーションロボットによるうつ病の早期支援のための補助的評価法の開発　　　　　　　　　　　　　　　
加藤隆弘
第118回日本精神神経学会学術総会 シンポジウム103 ヒューマノイドロボットがもたらす精神科医療の未来, 17 Jun. 2022

若手精神科医が力動精神医学・精神分析に触れる意義と難しさー九州大学での実践を通じて　　　　　　　　　　　　　　　
加藤隆弘
第118回日本精神神経学会学術総会 シンポジウム70 精神科専攻医が力動精神医学・精神分析的精神医学をどう学ぶか？, 17 Jun. 2022

線維筋痛症とミクログリア—ヒト血液由来ミクログリア様（iMG）細胞を用いた橋渡し研究　　　　　　　　　　　　　　　
加藤隆弘
第118回日本精神神経学会学術総会 シンポジウム64 慢性疼痛, 17 Jun. 2022

ひきこもりとグループ精神療法—集団の中で「ひきこもる能力」を獲得するために　　　　　　　　　　　　　　　
加藤隆弘
第118回日本精神神経学会学術総会 シンポジウム51 臨床に活きる集団精神療法の魅力, 17 Jun. 2022

脳外科疾患と炎症・可塑性に関する神経グリア理解—精神科医と脳外科医との連携　　　　　　　　　　　　　　　
加藤隆弘, 田中 俊也, 白水 寛理, 前原 直喜, 稲嶺 翔吾, 扇谷 昌宏, 秦 暢宏, 吉本 幸司
第118回日本精神神経学会学術総会 シンポジウム39 脳卒中・脳挫傷・脳腫瘍に伴う精神症状の概念的理解と診断・治療, 17 Jun. 2022

社会的ひきこもりとゲーム障害　　　　　　　　　　　　　　　
加藤隆弘
第118回日本精神神経学会学術総会 シンポジウム37 ゲーム障害は精神疾患なのか？, 16 Jun. 2022

精神分析という道：自由と不自由が共存する物理的時空間で獲得する心の自由　　　　　　　　　　　　　　　
加藤隆弘
第118回日本精神神経学会学術総会 シンポジウム 25 精神療法と技法―治療理論との必然的結びつきに着目して, 16 Jun. 2022

ヒト血液由来直接誘導ミクログリア様（iMG）細胞によるダイナミックな精神病理の探索　　　　　　　　　　　　　　　
加藤隆弘
第118回日本精神神経学会学術総会 シンポジウム10 ミクログリアの精神医学：脳内脇役細胞の働きから精神疾患の病態治療機序を再構築する, 16 Jun. 2022

ひきこもり及び統合失調症をもつ本人・家族への集団心理アプローチ－ひきこもる能力を育む居場所づくりー　　　　　　　　　　　　　　　
加藤 隆弘
Web Seminar－集団心理教育と薬物治療－, 31 May 2022

COVID-19 and pathological social withdrawal - Hikikomori　　　　　　　　　　　　　　　
Kato TA
Hikikomori in the pandemic at an international webinar, University of Siena, Italy, 30 May 2022

うつ病・発達障害を併存しがちな「社会的ひきこもり」の評価と治療戦略　　　　　　　　　　　　　　　
加藤隆弘
福岡県精神神経科診療所協会 令和4年度 学術講演会, 28 May 2022

精神分析からみた自殺とひきこもりの共通基盤（クロストーク）　　　　　　　　　　　　　　　
加藤隆弘, 衛藤暢明
Schizophrenia Psychotherapy & Drug therapy seminar, 26 May 2022

統合失調症・ひきこもりに対する精神分析的アプローチ　　　　　　　　　　　　　　　
加藤隆弘
Schizophrenia Psycho therapy & Drug therapy seminar, 26 May 2022

統合失調症から出発するひきこもりスペクトラムの病態理解と治癒戦略　　　　　　　　　　　　　　　
加藤 隆弘
Online Seminar in 大分, 15 Apr. 2022

統合失調症とひきこもり－病態理解と治療戦略－　　　　　　　　　　　　　　　
加藤隆弘
CNS CONFERENCE 久留米中央, 23 Mar. 2022

ひきこもり支援にグループの支援を活用する－MHFAとCRAFTを応用した引きこもる個人と集団の橋渡し－　　　　　　　　　　　　　　　
加藤隆弘
日本集団精神療法学会 第39回学術大会 大会企画ワークショップ, 19 Mar. 2022

ソーシャル・ディスタンスの維持と破綻に栄養・炎症・ミクログリアは関連するのか？−ひきこもり者の血液メタボローム解析の結果から考える　　　　　　　　　　　　　　　
加藤 隆弘, 瀬戸山 大樹, 康 東天
第95回日本薬理学会年会 シンポジウム： 恒常性破綻による精神病態に対する基礎神経科学の挑戦, 09 Mar. 2022

患者のミミクログリア活性化を血液で予測する：サロゲートマーカーとしてのヒト単球由来iMG細胞　　　　　　　　　　　　　　　
加藤隆弘, 扇谷 昌宏, 田中 俊也, 稲嶺 翔吾, 秦 暢宏
第95回日本薬理学会年会 シンポジウム：グリアと情動, 08 Mar. 2022

「新型/現代型うつ」と呼ばれる学生の心理的理解と対応.　　　　　　　　　　　　　　　
加藤隆弘
広島修道大学2021年度学生対応ガイダンス, 02 Mar. 2022

Hikikomori in Japan and Worldwide. Italian Seminar for Hikikomori Research and Clinical Practice　　　　　　　　　　　　　　　
Kato TA
Italian Seminar for Hikikomori Research and Clinical Practice, School of Human Health Sciences, University of Florence, Florence, Italy, 26 Feb. 2022

こころの痛みをミクログリアの病態生理から探る　　　　　　　　　　　　　　　
加藤隆弘
星薬科大学薬理学研究室セミナー, 22 Feb. 2022

強制治療を改めて考える　　　　　　　　　　　　　　　
加藤 隆弘(パネリスト)
第6回 多職種でリカバリーを学ぶ会, 18 Feb. 2022

REDCapを利用したe-Consentの実装　　　　　　　　　　　　　　　
下條 晃, 平田 早季, 坂井悟, 坂梨健二, 船越 公太, 河原直人, 加藤隆弘, 中島直樹, 馬場英司, 戸高浩司, 赤司浩一
臨床試験学会第13回学術集会, 04 Feb. 2022
04 Feb. 2022 - 05 Feb. 2022

統合失調症における神経免疫とミクログリア　　　　　　　　　　　　　　　
加藤隆弘
WEB講演会 in いわて, 01 Feb. 2022

ひきこもり支援におけるフューチャーデザインの活用　　　　　　　　　　　　　　　
加藤 隆弘
高知工科大学フューチャーデザイン研究所主催フューチャーデザイン2022, 30 Jan. 2022

精神疾患のミクログリア仮説に基づく新しい治療戦略　　　　　　　　　　　　　　　
加藤 隆弘
統合失調症Webセミナーin Kanagawa, 18 Jan. 2022

Pathological social withdrawal as a novel global mental health issue especially during the COVID-19 pandemic. ( Hikikomori and COVID19 Pandemic)　　　　　　　　　　　　　　　
Kato TA
26th Annual Adolescent Days, 03 Dec. 2021, English, Public discourse

うつ病のミクログリア仮説～抗炎症作用を目的とした栄養療法の可能性～　　　　　　　　　　　　　　　
加藤隆弘
第59回新潟精神医学懇話会, 19 Nov. 2021

Understanding and Treating Hikikomori (Pathological Social Withdrawal)　　　　　　　　　　　　　　　
Kato TA
Conférence lors du Psychiatrie & Psychothérapie Update Refresher, SWISSTECH EPFL, Lausanne-Ecublens, 18 Nov. 2021

うつ病のミクログリア仮説：栄養療法の可能性　　　　　　　　　　　　　　　
加藤隆弘
第61回中国四国精神神経学会/第44回中国四国精神保健学会共催 イブニングセミナー, 11 Nov. 2021

日本の精神療法の未来－エヴィデンス神話をエディプス神話から読み解く－.　　　　　　　　　　　　　　　
加藤 隆弘
日本精神分析学会第67回大会 エヴィデンスを考える集い, 06 Nov. 2021

Human blood-induced microglia-like (iMG) cells as a reverse translational research tool to clarify mind-brain-body interactions　　　　　　　　　　　　　　　
Kato TA
7th Congress of ASCNP 2021, Symposium 4: How do microglia contribute to psychiatric disorders? – Immunological crosstalk between mind and body, 22 Oct. 2021, English

Forced social isolation due to COVID-19 and the forthcoming mental health crisis in urban cities in Japan　　　　　　　　　　　　　　　
Kato TA
WPA Section on Urban Mental Health, 21st WPA (World Congress of Psychiatry) Symposium : Urban life, social isolation and psychopathology in the COVID-19 era
18 Oct. 2021 - 21 Oct. 2021

ヒト血液由来ミクログリア様（iMG）細胞：精神疾患・疼痛・脳腫瘍の病態解明・バイオマーカーとしての活用　　　　　　　　　　　　　　　
加藤隆弘
免疫エリアWEBセミナー, 07 Oct. 2021

ミクログリアと精神分析が出会ったら　　　　　　　　　　　　　　　
加藤 隆弘
第64回日本神経化学会大会 第14回若手研究者育成セミナー (セミナー講師), 30 Sep. 2021, Public discourse

社会的ひきこもりに対する多軸的な理解と治療：特に抑うつ・発達の評価の重要性　　　　　　　　　　　　　　　
加藤隆弘
メンタルケアWebセミナー in福岡, 28 Sep. 2021, Public discourse

自閉症スペクトラム症におけるひきこもりの生物心理社会的な共通基盤の解明　　　　　　　　　　　　　　　
山田 真理, 太田 晴久, 香月 亮子, 久保 浩明, 加藤 隆弘, 加藤 進昌, 岩波 明
第117回日本精神神経学会学術総会, Poster presentation
19 Sep. 2021 - 21 Sep. 2021

フロイトの寝椅子による「自由連想法」創出にみる精神分析と身体　　　　　　　　　　　　　　　
加藤隆弘
第117回日本精神神経学会学術総会 シンポジウム71：精神療法と身体, 21 Sep. 2021

うつ病・ひきこもり患者にロボットだからできる役割　　　　　　　　　　　　　　　
加藤隆弘, 松島敏夫, 松尾敬太朗, 吉川雄一郎, 熊崎博一
第117回日本精神神経学会学術総会 シンポジウム29：ロボット技術が精神科診療において果たす役割, 19 Sep. 2021

covid-19時代における「社会的ひきこもり」の新しい理解と精神分析　　　　　　　　　　　　　　　
加藤隆弘
第117回日本精神神経学会学術総会 シンポジウム33：covid-19時代の精神分析臨床, 19 Sep. 2021

コロナ禍で身近な人や自分自身がうつや病的ひきこもりにならないためにできること　　　　　　　　　　　　　　　
加藤 隆弘
一般社団法人日本うつ病センター主催 東京都地域自殺対策事業 地域特性重点特化事業 若年勤労者の自殺対策のための職場におけるメンタルヘルスの推進事業 2021年度「JDCメンタルヘルスセミナー 職場におけるメンタルヘルスの推進」WEBオンラインセミナー, 12 Sep. 2021, Public discourse

メンタルヘルスの不調を抱えた人への初期対応法～メンタルヘルス・ファーストエイドにもとづく短時間プログラム　　　　　　　　　　　　　　　
浦田 裕美, 加藤 隆弘
第5回日本精神薬学会総会・学術集会 ワークショップ, 22 Aug. 2021, Nominated symposium

うつ病のミクログリア仮説～抗炎症作用を目的とした栄養療法の可能性～　　　　　　　　　　　　　　　
加藤 隆弘
低亜鉛血症オンライン講演会, 05 Aug. 2021

ヒト血液由来ミクログリア様(iMG)細胞を用いた繊維筋痛症の病態解明とバイオマーカー開発　　　　　　　　　　　　　　　
加藤 隆弘
日本ペインクリニック学会第55回学術集会 シンポジウム3：「線維筋痛症の病態解析の最前線」, 23 Jul. 2021

うつ病の血液バイオマーカー：特に脳内免疫細胞ミクログリアに着目して　　　　　　　　　　　　　　　
加藤 隆弘
第18回日本うつ病学会総会/第21回日本認知療法・認知行動療法学会
08 Jul. 2021 - 10 Jul. 2021

うつ病患者におけるこころの痛みとからだの痛み：炎症に着目したリバース・トランスレーショナル研究　　　　　　　　　　　　　　　
加藤 隆弘
第62回日本心身医学会総会ならびに学術講演会, シンポジウム７：「慢性疼痛と心理社会的ストレス」, 10 Jul. 2021

ひきこもりスペクトラム概念による精神疾患の新しい評価・ 治療法の提案　　　　　　　　　　　　　　　
加藤 隆弘
精神科医療セミナー, 06 Jul. 2021, Public discourse

「コロナ禍のメンタルヘルス」～わたしってひきこもり？！.　　　　　　　　　　　　　　　
加藤 隆弘
令和3年度広島県精神保健福祉協会総会特別講演 地域精神保健研修会及びひきこもり支援研修会（Web開催）, 21 Jun. 2021, Public discourse

脳内免疫細胞ミクログリアによる心の不調と精神疾患：双方向性研究アプローチ　　　　　　　　　　　　　　　
加藤 隆弘
東京農業大学生命科学部バイオサイエンス学科 動物分子生物学研究室セミナー(Web開催), 16 Jun. 2021, Public discourse

オンライン、精神分析の実践と訓練の可能性（指定討論）　　　　　　　　　　　　　　　
加藤 隆弘
日本精神分析協会 精神分析的精神療法家センター総会、学術集会（Web開催）, 13 Jun. 2021

Psychiatric conditions that co-occur with hikikomori. Symposium 15: Hikikomori: An update on research on pathological social withdrawal.　　　　　　　　　　　　　　　
Kato TA
Pacific Rim College of Psychiatrists (PRCP 2021)（Web）, 09 Apr. 2021

ひきこもりとグループと集団精神療法―「集団の中でひきこもる能力」を獲得すること―　　　　　　　　　　　　　　　
加藤 隆弘
日本集団精神療法学会第38回学術大会 シンポジウム：「集団精神療法の知を問う」(Web開催), 21 Mar. 2021

Hikikomori in Japan and Worldwide　　　　　　　　　　　　　　　
Kato TA
Italian Seminar for Hikikomori Research and Clinical Practice, School of Human Health Sciences, University of Florence (Web), 14 Mar. 2021, Public discourse

Q&A and discussion: leading researcher in the field　　　　　　　　　　　　　　　
Kato TA
20th WPA World Congress of Psychiatry Session : DIFFICULT CASES 01: A PANEL DISCUSSION ON DIAGNOSTIC AND MANAGEMENT PROBLEMS ARISING ON DIFFERENT CONTINENTS (Web), 10 Mar. 2021

Forced social isolation and consequent mental health problems: lessons from hikikomori　　　　　　　　　　　　　　　
Kato TA
20th WPA World Congress of Psychiatry Symposium : PSYCHOSOCIAL CONSEQUENCES OF COVID-19 IN URBAN SETTINGS (Web), 09 Mar. 2021

The Associate Factors of Psychotropic Drug Prescribing　　　　　　　　　　　　　　　
Kato TA
20th WPA World Congress of Psychiatry Symposium: RESEARCH ON ASIAN PSYCHOTROPIC DRUG PRESCRIPTION PATTERN: PAST, PRESENT, AND FUTURE (Web), 09 Mar. 2021

ミクログリア分化異常からみた精神神経疾患：患者由来iMG細胞を用いた橋渡し研究　　　　　　　　　　　　　　　
加藤 隆弘
第94回日本薬理学会年会, シンポジウム９サブタイプ特異的な分化誘導技術を応用した標的ニューロン・グリア細胞における精神神経疾患研究の最前線 (Web開催), 08 Mar. 2021

社会的ひきこもりの多軸的理解と治療的介入: うつ・発達障害の併存とその対応　　　　　　　　　　　　　　　
加藤 隆弘
沖縄県精神科診療所協会学術講演会 (Web開催), 19 Feb. 2021, Public discourse

Directly induced microglia-like cells from blood monocytes for clarifying dynamic microglial pathophysiology in psychiatric disorders　　　　　　　　　　　　　　　
Kato TA
The Pennsylvania State University Pharmacology Seminar (Web), 11 Feb. 2021
[Invited]

Multidimensional Assessment of Hikikomori　　　　　　　　　　　　　　　
Kato TA
Online Symposium of The International Hikikomori Research Consortium, 06 Feb. 2021

うつ病・自殺のミクログリア仮説解明のための橋渡し研究　　　　　　　　　　　　　　　
加藤 隆弘
第17回日本うつ病学会総会 シンポジウム6「うつ病における炎症の役割」 (Web開催)
25 Jan. 2021 - 31 Jan. 2021

樽味の「ディスチミア親和型うつ」概念から出発した若年者の抑うつ症に関する多軸的臨床研究と治療法の概念　　　　　　　　　　　　　　　
加藤 隆弘
第17回日本うつ病学会総会 シンポジウム5「新型/現代型うつ」概念を臨床精神医学・心理学および文化社会的観点から再構築する(Web開催), 29 Jan. 2021

ひきこもりにおけるうつ病・発達障害の並存を考える　　　　　　　　　　　　　　　
加藤 隆弘
第17回日本うつ病学会総会 シンポジウム2「ひきこもりの包括的評価と病態・ステージに応じた支援」(Web開催), 27 Jan. 2021

未来のひきこもり支援におけるヒューマノイドロボットの活用　　　　　　　　　　　　　　　
加藤隆弘
第116回日本精神神経学会学術総会 シンポジウム33「自閉スペクトラム症者へのヒューマノイドロボット研究の今後の展望」(Web開催), 29 Sep. 2020

成人の勤労者におけるインターネット使用時間と、ネット依存度・抑うつ・パーソナリティ傾向との関連　　　　　　　　　　　　　　　
松尾敬太朗, 香月亮子, 久保浩明, 加藤隆弘
第116回日本精神神経学会学術総会 (Web開催), 29 Sep. 2020

フロイトの人間観：晩年の「死の欲動」の創出とその源泉にみる精神分析の目指すもの　　　　　　　　　　　　　　　
加藤隆弘
第116回日本精神神経学会学術総会 シンポジウム19「フロイト、ユング、森田の人間観とその精神療法が目指すもの」(Web開催）, 28 Sep. 2020, Others

ミクログリアの精神病理を探るためのヒト血液を用いた橋渡し研究　　　　　　　　　　　　　　　
加藤隆弘
第63回日本神経化学会大会 シンポジウム（Web開催）, Sep. 2020, Japanese
Web開催, Japan

神経グリア発達によるモチベーションの形成とその破綻・修復機構の解明　　　　　　　　　　　　　　　
加藤 隆弘
文科省科研費 新学術領域研究 「意志動力学（ウィルダイナミクス）の創成と推進」 2020 年度 領域全体 Web 会議, Aug. 2020, Japanese
Japan

ヒト血液を用いた精神疾患ミクログリア仮説解明のための橋渡し研究　　　　　　　　　　　　　　　
加藤 隆弘
第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会（NPBPPP2020合同年会）（Web開催）, Aug. 2020, Japanese
Japan

“みんなのひきこもり”時代におけるグループ　　　　　　　　　　　　　　　
加藤隆弘
北海道集団精神療法研究会 第17回学術研修会（Web開催）, Jun. 2020, Japanese
Japan

社会的ひきこもりの精神分析的集団精神療法−グループからの卒業をめぐって−　　　　　　　　　　　　　　　
久保浩明, 加藤隆弘
日本集団精神療法学会 第37回学術大会, Mar. 2020, Japanese
大阪経済大学（紙上開催）, Japan

〔Major achievements〕ミクログリア分化異常からみた精神神経疾患：患者由来iMG細胞を用いた橋渡し研究　　　　　　　　　　　　　　　
加藤隆弘, 扇谷昌宏, 稲嶺翔吾, 佐方巧明, 神庭重信
第93回日本薬理学会年会 シンポジウム：細胞分化異常応答と神経疾患, Mar. 2020, Japanese
パシフィコ横浜会議センター（紙上開催）, Japan

Proposing a Novel Metabolomic Analysis using Free Form of Plasma Metabolites as More Specific Biomarkers for Major Depressive Disorders　　　　　　　　　　　　　　　
Kato TA, Setoyama D, Kang D, Kanba S
ACNP 58th Annual Meeting, Dec. 2019, English
Hilton Orlando Bonnet Creek and Waldorf Astoria Orlando, Orlando(Florida), United States, [International presentation]

うつ病患者における信頼ゲームを用いた意思決定行動の特徴：症例対照研究による認知心理学的検討　　　　　　　　　　　　　　　
久保浩明, 渡部幹, 加藤隆弘
日本基礎心理学会第38回大会, Dec. 2019, Japanese
神戸大学六甲台第２キャンパス(神戸市)」, Japan

女性性の理論と臨床をアップデイトする　　　　　　　　　　　　　　　
加藤隆弘
日本精神分析学会第65回大会 教育研修セミナー, Oct. 2019, Japanese
札幌コンベンションセンター(札幌市), Japan, [Domestic Conference]

〔Major achievements〕発達障害とひきこもり－大学病院ひきこもり外来での取り組み　　　　　　　　　　　　　　　
加藤隆弘
第7回成人発達障害支援学会 シンポジウム③「発達障害とひきこもり」, Oct. 2019, Japanese
金城学院大学(名古屋市), Japan

REAP case-vignette survey (REAP-CV) for clarifying psychiatrists’ decision-making process of therapeutic choice: International comparison analysis　　　　　　　　　　　　　　　
Kato TA, Shinfuku N, Kanba S
6th Congress of AsCNP Asian College of Neuropsychopharmacology Symposium： New development of Research in Asian Psychotropic Drug Prescription (REAP), Oct. 2019, English
Fukuoka International Congress Center(Fukuoka), Japan, [International presentation]

〔Major achievements〕Human blood-based microglia monitoring system as a novel translational research tool for psychiatric disorders　　　　　　　　　　　　　　　
Kato TA, Ohgidani M, Setoyama D, Kang D, Kanba S
6th Congress of AsCNP Asian College of Neuropsychopharmacology Symposium：Glia-Psycho-Pathology: Findings from Rodent Models to Human Subjects, Oct. 2019, English
Fukuoka Sunpalace Hotel and Hall(Fukuoka), Japan, [International presentation]

非内因性うつ病（いわゆる「現代うつ」）および不安障害・発達障害合併例における抗うつ薬治療の意義　　　　　　　　　　　　　　　
加藤隆弘
日本臨床精神神経薬理学会 シンポジウム：これからの、抗うつ薬を用いたうつ病治療の展望, Oct. 2019, Japanese
福岡国際会議場(福岡市), Japan

ヒト血液由来ミクログリア様（iMG）細胞による線維筋痛症の客観的バイオマーカー開発研究.　　　　　　　　　　　　　　　
加藤隆弘, 扇谷昌宏, 細井昌子
日本線維筋痛症学会 第11回学術集会 シンポジウム：最先端のバイオマーカー, Oct. 2019, Japanese
シェーンバッハ・サボー(東京都), Japan

Hikikomori in Japan and worldwide:Multidimensional Assessment and Intervention　　　　　　　　　　　　　　　
Kato TA
AsCNP-ASEAN Pre-Congress Meeting of Neuropsychopharmacology: Bridging Research Collaboration between AsCNP and ASEAN Region in Psychiatric Field, Oct. 2019, English
Fukuoka International Congress Center(Fukuoka), Japan, [International presentation]

〔Major achievements〕ひきこもりの多面的評価システムに基づく具体的な支援　　　　　　　　　　　　　　　
加藤隆弘
第20回日精診チーム医療・地域リハビリテーション研修会九州大会 メインシンポジウム：ひきこもりという生き方を支援する, Oct. 2019, Japanese
九州大学医学部百年講堂(福岡市), Japan

Development of the 22-item Tarumi’s Modern-Type Depression Trait Scale: Avoidance of Social Roles, Complaint, and Low Self-Esteem(TACS-22)　　　　　　　　　　　　　　　
Katsuki R, Kubo H, Kanba S, Kato TA
The 20th Korea Japan Young Psychiatrists’ Conference, Sep. 2019, English
Chung Ang University Hospital(Seoul), Korea, Republic of, [International presentation]

Development of 5-day hikikomori intervention program for family members: A single-arm trial　　　　　　　　　　　　　　　
Kubo H, Urata H, Kuroki T, Kanba S, Kato TA
The 20th Korea Japan Young Psychiatrists’ Conference, Sep. 2019, English
Chung Ang University Hospital(Seoul), Korea, Republic of, [International presentation]

〔Major achievements〕Rural urban migration, social isolation and Impact on mental health.　　　　　　　　　　　　　　　
Kato TA, Shinfuku N, Teo AR, Kanba S
19th WPA World Congress of Psychiatry (WCP) Scientific Session: MENTAL HEALTH IN URBAN LIVING (SYMPOSIUM), Aug. 2019, English
Lisboa Congress Centre(Lisbon), Portugal, [International presentation]

Defining pathological social withdrawal: A proposal for diagnostic criteria of hikikomori.　　　　　　　　　　　　　　　
Kato TA, Kanba S, Teo AR
19th WPA World Congress of Psychiatry (WCP) Free Communication Session - AFFECTIVE AND OTHER NON-PSYCHOTIC DISORDERS, Aug. 2019, English
Lisboa Congress Centre(Lisbon), Portugal, [International presentation]

Bio-psycho-social understanding of hikikomori and modern-type depression in Japan　　　　　　　　　　　　　　　
Kato TA
Osakidetza (Servicio Vasco de Salud/Basque Health System), Aug. 2019, English
Basque Health Service(Basque), Spain, [Invited], [International presentation]

〔Major achievements〕Hikikomori and Modern-Type Depression in Japan: Assessment and Intervention　　　　　　　　　　　　　　　
Kato TA
Special Lecture :The University of Sydney School of Pharmacy, Aug. 2019, English
The University of Sydney School of Pharmacy, Australia, [International presentation]

Microglia-focused neuropsychiatric translational research using human bloods; dynamic cellular analysis using induced microglia-like (iMG)cells and various plasma analysis.　　　　　　　　　　　　　　　
Kato TA, Ohgidani M, Kanba S
Neuro 2019 Symposium: Roles of epigenetics and inflammation in mental illness, Jul. 2019, English
朱鷺メッセ(新潟市), Japan, [International presentation]

Why do we need translational research of psychiatric disorders using human directly induced (iN) cells?.　　　　　　　　　　　　　　　
Sagata N, Kato TA
Neuro 2019 Symposium: Interpretation of human brain mechanisms and drug discovery using leading-edge stem cell technologies, Jul. 2019, English
朱鷺メッセ(新潟市), Japan, [International presentation]

〔Major achievements〕精神疾患患者の血液を用いたミクログリア仮説解明のための橋渡し研究.　　　　　　　　　　　　　　　
加藤隆弘, 扇谷昌宏, 神庭重信
NEURO2019 シンポジウム：精神疾患におけるエピゲノムと炎症の役割, Jul. 2019, Japanese
朱鷺メッセ(新潟市), Japan

「現代抑うつ症候群」（いわゆる「現代型うつ」「新型うつ」）の病前性格：22項目の自記式評価尺度（TACS-22）の開発　　　　　　　　　　　　　　　
香月亮子, 久保浩明, 桑野信貴, 瀬戸山大貴, 康東天, 渡部幹, 坂本真士, Teo Alan R., 神庭重信, 加藤隆弘
第16回日本うつ病学会総会, Jul. 2019, Japanese
あわぎんホール(徳島市), Japan, [Domestic Conference]

〔Major achievements〕ミクログリアと精神疾患：トランスレーショナル研究　　　　　　　　　　　　　　　
加藤隆弘
第41回日本生物学的精神医学会, Jun. 2019, Japanese
朱鷺メッセ(新潟市), Japan

〔Major achievements〕Does internet assist hikikomori-like behaviors based on the urban boundless society?　　　　　　　　　　　　　　　
Kato TA
6th International Conference on Behavioral Addictions (ICBA 2019) Symposium18 Internet addiction and interpersonal relations: connectedness and severe social withdrawal, hikikomori, Jun. 2019, English
PACIFICO Yokohama(横浜市), Japan, [International presentation]

〔Major achievements〕ひきこもり治療にロボットをどう活かすか？ドラえもんがのび太を救う.　　　　　　　　　　　　　　　
加藤隆弘
第115回日本精神神経学会学術総会 シンポジウム8「精神神経科領域におけるロボット治療の現状と今後の課題」, Jun. 2019, Japanese
朱鷺メッセ(新潟市), Japan, [Domestic Conference]

〔Major achievements〕ミクログリアと心：脳内免疫細胞が心理社会的活動とその破綻に関わる可能性.　　　　　　　　　　　　　　　
加藤隆弘
第115回日本精神神経学会学術総会 シンポジウム「ミクログリアは精神疾患の成り立ちにどのように関与するか」, Jun. 2019, Japanese
朱鷺メッセ(新潟市), Japan, [Domestic Conference]

〔Major achievements〕Hikikomori-Multidimensional understanding, assessment and therapeutic approach in Japan　　　　　　　　　　　　　　　
Kato TA
Strength-based Youth Work Conference, Jun. 2019, English
City University of Hong Kong(Hong Kong), China, [International presentation]

〔Major achievements〕精神疾患と緩和−脳内免疫細胞ミクログリアから心と体の痛みとその緩和を考える　　　　　　　　　　　　　　　
加藤隆弘
第13回日本緩和医療薬学会年会 シンポジウム：「精神疾患の緩和」, Jun. 2019, Japanese
幕張メッセ 国際会議場(千葉市), Japan, [Domestic Conference]

「ひきこもる」という病理現象にフォーカスを当てた疾患横断的研究とその治療戦略　　　　　　　　　　　　　　　
加藤隆弘
第22回多摩Schizophrenia研究会, May 2019, Japanese
パレスホテル立川(立川市), Japan

ヒト血液を用いた精神疾患トランスレーショナル研究：直接誘導ミクログリア様細胞の作成とその応用　　　　　　　　　　　　　　　
加藤隆弘
シグナル伝達医学講演会, Apr. 2019, Japanese
神戸大学医学部付属病院, Japan

ヒト血液由来ミクログリア様（iMG）細胞を用いた精神疾患トランスレーショナル研究.　　　　　　　　　　　　　　　
加藤隆弘, 扇谷昌宏, 神庭重信
日本薬学会 第139年会 一般シンポジウム「変わりゆくグリア細胞の役割～ミクログリア目線で疾患を診る！」, Mar. 2019, Japanese
幕張メッセ 国際会議場 （千葉市）, Japan

メタボローム解析によるうつ病のバイオマーカー探索.　　　　　　　　　　　　　　　
康東天, 瀬戸山大樹, 加藤隆弘, 神庭重信
日本薬学会第139年会 一般シンポジウム「第3回 臨床化学の進歩が変える薬物治療～臨床検査と薬学の融合～」, Mar. 2019, Japanese
幕張メッセ 国際会議場 （千葉市）, Japan

ひきこもりに対する精神分析的アプローチ-精神分析的臨床とミクログリア研究から考える-　　　　　　　　　　　　　　　
加藤隆弘
第71回九州精神神経学会 ポストイベント（日本精神分析学会 医療問題委員会企画）シンポジウム「精神分析的臨床のいま」, Feb. 2019, Japanese
福岡国際会議場 （福岡市）, Japan