論文

• 肺虚血再灌流傷害におけるエリスロポエチンアナログ製剤の効果　　　　　　　　　　　　　　　
  椎谷 洋彦, 渡辺 正明, 千葉 龍平, 佐々木 明洋, 大高 和人, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加藤 達哉
  移植, 59, 総会臨時, 375, 375, (一社)日本移植学会, 2024年09月
  日本語
• 先天性嚢胞性肺疾患に対するReduced port VATSの取り組み　　　　　　　　　　　　　　　
  藤原 晶, 高桑 佑佳, 佐々木 明洋, 椎谷 洋彦, 大高 和人, 氏家 秀樹, 新垣 雅人, 本多 昌平, 川原 仁守, 加藤 達哉
  日本気胸・嚢胞性肺疾患学会雑誌, 24, 2, 86, 86, 日本気胸・嚢胞性肺疾患学会, 2024年08月
  日本語
• ラット虚血再灌流傷害モデルを用いた新規抗炎症薬による肺傷害抑制効果の検討　　　　　　　　　　　　　　　
  椎谷 洋彦, 千葉 龍平, 渡辺 正明, 大塚 将平, 佐々木 明洋, 大高 和人, 氏家 秀樹, 藤原 晶, 新垣 雅人, 加藤 達哉
  移植, 59, 1, 88, 88, (一社)日本移植学会, 2024年07月
  日本語
• 肺移植クラウドファンディングを経験して　　　　　　　　　　　　　　　
  加藤 達哉, 大塚 将平, 佐々木 明洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 氏家 秀樹, 新垣 雅人
  移植, 59, 1, 101, 101, (一社)日本移植学会, 2024年07月
  日本語
• Impact of pulmonary vein-first ligation during lobectomy on the postoperative survival and recurrence rates in patients with non-small cell lung cancer: a multicenter propensity score-matched study.
  Haruhiko Shiiya, Hideki Ujiie, Ryohei Chiba, Shunsuke Nomura, Kazuto Ohtaka, Aki Fujiwara-Kuroda, Masato Aragaki, Keita Takahashi, Kazufumi Okada, Tatsuya Kato
  Surgery today, 2024年05月30日, ［国内誌］
  英語, 研究論文（学術雑誌）, PURPOSE: Surgical manipulation of the lungs increases the number of circulating tumor cells and the subsequent risk of metastasis in patients with lung cancer. This study investigated whether or not ligating the tumor-draining pulmonary vein first during lobectomy could improve the prognosis of these patients. METHODS: We retrospectively evaluated patients who underwent curative lobectomy for solitary nonsmall-cell lung carcinoma between January 2012 and December 2016. We divided the patients into the vein-first group, in which all associated pulmonary veins were dissected and severed before cutting the pulmonary artery, bronchus, or pulmonary fissure, and the other procedure group. RESULTS: Overall, we included 177 and 413 patients in the vein-first and other procedure groups, respectively. Propensity score matching yielded 67 pairs of patients. The 5-year overall survival (85.6% [95% confidence interval, 77.3-94.8%] vs. 69.4% [58.7-81.9%], P = 0.03%) and recurrence-free survival (73.4% [63.3-85.1%] vs. 53.5% [42.5-67.3%], P = 0.02) were significantly better in the vein-first group than in the other procedure group. The cumulative recurrence rate at 5 years post-surgery was significantly lower in the vein-first group than in the other procedure group (21.7% vs. 38.3%, P = 0.04). CONCLUSION: Our study suggests that ligating the pulmonary vein first during lobectomy for lung cancer can improve the overall survival, recurrence-free survival, and cumulative recurrence rate.
• 低侵襲手術の未来像 Reduced port Robot-assisted thoracic surgery(RATS)の未来
  氏家 秀樹, 大塚 将平, 佐々木 明洋, 山崎 洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 新垣 雅人, 江花 弘基, 加藤 達哉
  気管支学, 46, Suppl., S171, S171, (一社)日本呼吸器内視鏡学会, 2024年05月
  日本語
• 低侵襲手術の未来像 Reduced port Robot-assisted thoracic surgery(RATS)の未来
  氏家 秀樹, 大塚 将平, 佐々木 明洋, 山崎 洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 新垣 雅人, 江花 弘基, 加藤 達哉
  気管支学, 46, Suppl., S171, S171, (一社)日本呼吸器内視鏡学会, 2024年05月
  日本語
• A simple and safe surgical technique for nonpalpable lung tumors: One-stop Solution for a nonpalpable lung tumor, Marking, Resection, and Confirmation of the surgical margin in a Hybrid operating room (OS-MRCH).
  Aki Fujiwara-Kuroda, Masato Aragaki, Yasuhiro Hida, Hideki Ujiie, Kazuto Ohtaka, Haruhiko Shiiya, Kichizo Kaga, Tatsuya Kato
  Translational lung cancer research, 13, 3, 603, 611, 2024年03月29日, ［国際誌］
  英語, 研究論文（学術雑誌）, When performing thoracoscopic partial resections of nonpalpable lung tumors such as ground-glass opacities (GGOs) and small tumors, detecting the location of the lesion and assessing the resection margins can be challenging. We have developed a novel method to ease this difficulty, the One-stop Solution for a nonpalpable lung tumor, Marking, Resection, and Confirmation of the surgical margin in a Hybrid operating room (OS-MRCH), which uses a hybrid operating room wherein the operating table is seamlessly integrated with cone-beam computed tomography (CBCT). We performed the OS-MRCH method on 62 nodules including primary lung cancer presenting with GGO. Identification of the lesion and confirmation of the margin were performed in 58 of the cases, while nodules were detected in all. The frequency of computed tomography (CT) scans performed prior to resection was one time in 51 cases, two times in eight cases, and ≥3 times in three cases. Additional resection was performed in two cases. The median operative time was 85.0 minutes, and the median pathological margin was 11.0 mm. The key advantages of this method are that all surgical processes can be completed in a single session, specialized skill sets are not required, and it is feasible to perform in any facility equipped with a hybrid operating room. To overcome its disadvantages, such as longer operating time and limited patient positioning, we devised various methods for positioning patients and for CT imaging of the resected specimens. OS-MRCH is a simple, useful, and practical method for performing thoracoscopic partial resection of nonpalpable lung tumors.
• 薄壁空洞性病変を呈した原発性肺扁平上皮内癌の1例
  佐々木 明洋, 新垣 雅人, 竹野 巨樹, 山崎 洋, 野村 俊介, 大高 和人, 藤原 晶, 氏家 秀樹, 榊原 純, 大川 紘弥, 松野 吉宏, 加藤 達哉
  気管支学, 45, 6, 443, 443, (一社)日本呼吸器内視鏡学会, 2023年11月
  日本語
• 肺胞出血を合併したLymphangioleiomyomatosisの1例　　　　　　　　　　　　　　　
  大高 和人, 竹野 巨樹, 山崎 洋, 佐々木 明洋, 野村 俊介, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加藤 達哉, 武井 望, 小熊 昂, 今野 哲, 大川 紘弥, 松野 吉宏
  日本気胸・嚢胞性肺疾患学会雑誌, 23, 2, 90, 90, 日本気胸・嚢胞性肺疾患学会, 2023年08月
  日本語
• 肺胞出血を合併したLymphangioleiomyomatosisの1例　　　　　　　　　　　　　　　
  大高 和人, 竹野 巨樹, 山崎 洋, 佐々木 明洋, 野村 俊介, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加藤 達哉, 武井 望, 小熊 昂, 今野 哲, 大川 紘弥, 松野 吉宏
  日本気胸・嚢胞性肺疾患学会雑誌, 23, 2, 90, 90, 日本気胸・嚢胞性肺疾患学会, 2023年08月
  日本語
• Metastatic lung tumor from hepatocellular carcinoma with tumor thrombus invasion in the pulmonary vein: a case report.
  Kazuto Ohtaka, Setsuyuki Ohtake, Yu Ishii, Saya Kaku, Yuta Takeuchi, Tomoko Mizota, Yoshiyuki Yamamura, Masaomi Ichinokawa, Tatsuya Yoshioka, Eiji Tamoto, Katsuhiko Murakawa, Koichi Ono
  Journal of cardiothoracic surgery, 18, 1, 167, 167, 2023年04月28日, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Metastatic lung tumor with a tumor thrombus in the peripheral pulmonary vein is very rare. We present a case of a metastatic lung tumor from hepatocellular carcinoma (HCC) with tumor thrombus invasion in the pulmonary vein that was diagnosed preoperatively and underwent complete resection by segmentectomy. CASE PRESENTATION: A 77-year-old man underwent laparoscopic lateral segment hepatectomy for HCC eight years ago. Protein induced by vitamin K absence or antagonist-II remained elevated from two years ago. Contrast-enhanced chest computed-tomography (CT) showed a 27 mm nodule in the right apical segment (S1). He was pathologically diagnosed with a metastatic lung tumor from HCC via transbronchoscopic biopsy. We planned to perform right S1 segmentectomy. Before surgery, contrast-enhanced CT in the pulmonary vessels phase for three-dimensional reconstruction showed that the tumor extended into the adjusting peripheral pulmonary vein, and we diagnosed tumor thrombus invasion in V1a. The surgery was conducted under 3-port video-assisted thoracic surgery. First, V1 was ligated and cut. A1 and B1 were cut. The intersegmental plane was cut with mechanical staplers. Pathological examination revealed moderately-differentiated metastatic HCC with tumor thrombus invasions in many pulmonary veins, including V1a. No additional postoperative treatments were performed. CONCLUSIONS: As malignant tumors tend to develop a tumor thrombus in the primary tumor, it might be necessary to perform contrast-enhanced CT in the pulmonary vessel phase to check for a tumor thrombus before the operation for metastatic lung tumors.
• Small-sized peripheral squamous cell lung carcinoma with chest wall invasion.
  Shinya Otsuka, Kei Hiraoka, Kazuto Ohtaka, Nozomu Iwashiro, Noriko Kimura, Kichizo Kaga, Masanori Ohara
  Respiratory medicine case reports, 36, 101589, 101589, 2022年, ［国際誌］
  英語, In lung cancer, chest wall infiltration caused by a tumor with a small diameter is extremely rare. The pathophysiologic features and prognosis of this phenomenon are poorly understood. Here, we report on a case in which a small peripheral lung cancer showed marked invasion into the chest wall. Although complete resection and postoperative adjuvant treatment were performed, lymph node recurrence developed and the patient died in one and a half years. Peripheral lung cancer can show exophytic development and infiltration of the chest wall, leading to poor prognosis, even if the tumor size is relatively small.
• Hepatocellular carcinoma with regional lymphadenopathy caused by sarcoid-like reaction: a case report.
  Tomoko Mizota, Masato Suzuoki, Saya Kaku, Kenichi Mizunuma, Kazuto Ohtaka, Ryo Takahashi, Kazuteru Komuro, Nozomu Iwashiro, Masanori Ohara, Noriko Kimura, Satoshi Hirano
  Surgical case reports, 7, 1, 63, 63, 2021年03月04日, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Sarcoid-like reaction (SLR) is a histological pattern of granulomatous inflammation that is clinically differentiated from sarcoidosis. Since SLR is known to occur in several neoplasias and occasionally causes lymphadenopathy and mimics metastatic malignancy, it needs to be considered whether lymphadenopathy is due to metastasis or SLR for the choice of cancer treatment. Few cases of hepatocellular carcinoma (HCC) with SLR have been reported. Here, a case of HCC with lymphadenopathy diagnosed as SLR without metastasis is presented. CASE PRESENTATION: A 69-year-old woman was admitted to our hospital because of upper abdominal pain. She tested positive for hepatitis C virus ribonucleic acid. Imaging modalities showed an 81 × 65-mm-sized tumor with multiple nodules in segment 3 and a 17 × 12-mm-sized tumor in segment 5 with a common HCC enhancement pattern. In addition, a lymph node in the hepatoduodenal ligament was enlarged at 13 mm in size, suggesting the metastasis of HCC. Hepatectomy of the lateral segment and segment 5 and lymph node dissection in the hepatoduodenal ligament were performed. Both tumors in segments 3 and 5 were pathologically diagnosed as HCC without vessel invasion. The tumors contained necrotic cells and epithelioid cell granulomas with multinucleated giant cells, which is typically observed in sarcoidosis. The dissected lymph nodes also contained epithelioid cell granulomas, as well as giant cells with asteroid bodies. There was no malignancy in the lymph nodes. The pathological findings suggested the coexistence of malignancy and sarcoidosis. However, since the patient did not show any typical findings of pulmonary or cardiac sarcoidosis, the case was diagnosed as HCC with SLR in the primary lesion and regional lymph nodes. CONCLUSIONS: SLR needs to be considered in the differential diagnosis when a cancer patient develops lymphadenopathy. However, lymphadenopathy due to SLR is indistinguishable from that due to metastasis even when using multiple imaging modalities. Pathological examinations may be helpful for the diagnosis.
• A left lung abscess with a displaced subsegmental bronchus and anomalous pulmonary artery and vein: a case report.
  Kazuto Ohtaka, Nozomu Iwashiro, Kazunori Watanabe, Tomoko Mizota, Ryo Takahashi, Masato Suzuoki, Kazuteru Komuro, Masanori Ohara, Kichizo Kaga, Yoshiro Matsui
  Surgical case reports, 5, 1, 66, 66, 2019年04月23日, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Since a displaced bronchus related to the left upper lobe is an uncommon anatomical anomaly, it has a risk of being accidentally resected during left upper lobe resection unless they are identified preoperatively. A case of video-assisted thoracic surgery (VATS) segmentectomy that was safely performed under preoperative identification of a displaced subsegmental bronchus and anomalous pulmonary vessels is presented. CASE PRESENTATION: A 48-year-old woman visited our hospital because of an abnormal shadow on a radiograph on a health check. The chest computed tomography (CT) showed a multicystic mass with a diameter of 35 mm on dorsal interlobar parenchyma between the S1+2 and S6 segments in the left lung. The three-dimensional (3D) CT with multiplanar reconstruction showed that B1+2b+c passed to the dorsal side of the left main pulmonary artery (PA), which was considered a displaced bronchus. The branch of A6 arose from the left main PA at the level of the branches of A3 and A1+2, more proximal than the normal anatomy, and passed to the dorsal side of a displaced B1+2b+c. The branch of V1+2 passed between B6 and the bronchus to the basal segment and joined V6 at the dorsal side of the pulmonary hilum. Intraoperative findings of the anatomy of the bronchi and pulmonary vessels were exactly the same as the preoperative 3D CT findings, so segmentectomy of S1+2b+c and S6 by VATS was performed safely. Then there were accessory fissures between S1+2 and S3 and between S6 and the basal segment. The pathological diagnosis was a left lung abscess. CONCLUSIONS: A preoperative 3D CT may be helpful for identifying anatomical anomalies. An anatomical anomaly should be suspected if accessory fissure is found during surgery.
• 腹腔鏡下鼠径ヘルニア修復術における5mmポート3本での有用性 当院での経験　　　　　　　　　　　　　　　
  サシーム・パウデル, 渡邊 一永, 佐藤 彰記, 大高 和人, 細井 勇人, 東海林 安人, 長谷 龍之介, 仙丸 直人, 平野 聡
  日本外科学会定期学術集会抄録集, 118回, 1325, 1325, (一社)日本外科学会, 2018年04月
  日本語
• Long-term survival after repeated resection of metachronous lung metastases from pStage IA pancreatic adenocarcinoma.
  Mamoru Miyasaka, Takehiro Noji, Kazuto Ohtaka, Ryohei Chiba, Shoki Sato, Yasuhito Shoji, Ryunosuke Hase, Tatsunosuke Ichimura, Satoshi Hirano, Naoto Senmaru
  Clinical journal of gastroenterology, 11, 1, 53, 61, 2018年02月, ［国内誌］
  英語, 研究論文（学術雑誌）, CASE REPORT: A 70-year-old woman with pancreatic ductal adenocarcinoma was initially treated by distal pancreatectomy (DP). Thirty-five months later, another tumor appeared in the pancreatic head and was treated by pancreaticoduodenectomy. Histopathological findings identified both tumors as pancreatic ductal adenocarcinoma pStage IA. Computed tomography (CT) of the chest 16 months after the second pancreatectomy revealed a ground-glass opacity in segment 3 of the right lung. Chest CT 23 months after the second pancreatectomy revealed a nodular shadow in segment 1a of the right lung. Chest CT 39 months after the second pancreatectomy revealed a nodular shadow in segment 5 of the left lung. These lesions were treated by video-assisted thoracoscopic surgery partial resection. Histopathological and immunohistochemical features (positive for cytokeratin (CK)7 and CK20, negative for transcription factor-1) for these three lesions and the secondary pancreatic ductal adenocarcinoma were similar, indicating a diagnosis of lung metastasis from the second pancreatic ductal adenocarcinoma. The patient has remained alive and free of new metastases for 8 years after initial DP, 3 years after the last lung resection. CONCLUSION: This patient has survived over the long term after undergoing three resections of lung metastases from resected pancreatic ductal adenocarcinoma.
• Noninvasive management for iatrogenic splenic injury caused by chest tube insertion: a case report.
  Kazuto Ohtaka, Ryunosuke Hase, Ryohei Chiba, Mamoru Miyasaka, Shoki Sato, Yasuhito Shoji, Tatsunosuke Ichimura, Naoto Senmaru, Kichizo Kaga, Yoshiro Matsui
  Clinical case reports, 4, 12, 1157, 1160, 2016年12月, ［国際誌］
  英語, Splenic injury is one of the most critical complications of chest tube insertion and often requires invasive emergency management. However, noninvasive management such as delayed removal of the malpositioned tube may be considered for a stable patient without severe adverse event.
• Risk Factors for Difficult Laparoscopic Cholecystectomy in Acute Cholecystitis.
  Satoshi Hayama, Kazuto Ohtaka, Yasuhito Shoji, Tatsunosuke Ichimura, Miri Fujita, Naoto Senmaru, Satoshi Hirano
  JSLS : Journal of the Society of Laparoendoscopic Surgeons, 20, 4, 2016年, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND AND OBJECTIVES: Factors that contribute to difficult laparoscopic cholecystectomy (LC) in acute cholecystitis (AC) that would affect the performance of early surgery remain unclear. The purpose of this study was to identify such risk factors. METHODS: One hundred fifty-four patients who underwent LC for AC were retrospectively analyzed. The patients were categorized into early surgery and delayed surgery. Factors predicting difficult LC were analyzed for each group. The operation time, bleeding, and cases of difficult laparoscopic surgery (CDLS)/conversion rate were analyzed as an index of difficulty. Analyses of patients in the early group were especially focused on 3 consecutive histopathological phases: edematous cholecystitis (E), necrotizing cholecystitis (N), suppurative/subacute cholecystitis (S). RESULTS: In the early group, the CDLS/conversion rate was highest in necrotizing cholecystitis. Its rate was significantly higher than that of the other 2 histopathological types (N 27.9% vs E and S 7.4%; P = .037). In the delayed-surgery group, a higher white blood cell (WBC) count and older age showed significant correlations with the CDLS/conversion rate (P = .034 and P = .004). CONCLUSION: In early surgery, histopathologic necrotizing cholecystitis is a risk factor for difficult LC in AC. A higher WBC count and older age are risk factors for delayed surgery.
• Laparoscopic reduction and repair for incarcerated obturator hernia: comparison with open surgery
  S. Hayama, K. Ohtaka, Y. Takahashi, T. Ichimura, N. Senmaru, S. Hirano
  Hernia, 19, 5, 809, 814, Springer-Verlag France, 2015年10月01日, ［査読有り］
  英語, 研究論文（学術雑誌）, Purpose: Transabdominal preperitoneal (TAPP) repair for obturator hernia (OH) is not well established. Therefore, we evaluated the efficacy of TAPP for OH repair compared with open surgery. Methods: We retrospectively analyzed patients who underwent surgery for OH at our hospital between 2006 and 2011. Since 2009, we have used TAPP repair for OH instead of open surgery. The clinical results of TAPP repair were compared with those of open surgery performed before 2008. Results: Six patients with OH were treated by TAPP repair
  occult contralateral OH was found by laparoscopic exploration in three (50 %) patients and was simultaneously repaired. Bowel incarceration was reduced by water pressure through Nelaton catheter in all but one patient. Bowel resection was performed in two patients after the laparoscopic assessment. For incarcerated OH, five of six cases were repaired using synthetic mesh, and the remaining case was addressed with simple peritoneal closure. Before 2008, six patients with OH underwent open surgery. The background of patients was comparable in the TAPP group and the open surgery group. There were no deaths in either group, but one metachronous contralateral OH occurred in the open surgery group within a short time frame, whereas none occurred in the TAPP group. Conclusions: TAPP repair, including the inspection of the viability of the incarcerated intestine and protective reduction and assessment of the entire groin area is an effective and minimally invasive strategy for OH patients.
• Blood stasis may cause thrombosis in the left superior pulmonary vein stump after left upper lobectomy.
  Kazuto Ohtaka, Yasuhiro Takahashi, Satoko Uemura, Yasuhito Shoji, Satoshi Hayama, Tatsunosuke Ichimura, Naoto Senmaru, Yasuhiro Hida, Kichizo Kaga, Yoshiro Matsui
  Journal of cardiothoracic surgery, 9, 159, 159, 2014年09月18日, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: We previously reported that arterial infarction of vital organs after lobectomy might occur only after left upper lobectomy and be caused by thrombosis in the left superior pulmonary vein stump. We hypothesized that changes in blood flow, such as blood stasis and disturbed stagnant flow, in the left superior pulmonary vein stump cause thrombosis, and this was evaluated by intraoperative ultrasonography. METHODS: From July 2013 to April 2014, 24 patients underwent lobectomy in the Steel Memorial Muroran Hospital. During the procedure, an ultrasound probe was placed at the pulmonary vein stump and the velocity in the stump was recorded with pulse Doppler mode. The peak velocity and the presence of spontaneous echo contrast in the stump were evaluated. After the operation, the patients underwent contrast-enhanced CT within 3 months. RESULTS: The operative procedures were seven left upper lobectomies, four left lower lobectomies, seven right upper lobectomies, and six right lower lobectomies. Blood flow was significantly slower in the left superior pulmonary vein stump than in the right pulmonary vein stumps. However, that was not significantly slower than that in the left inferior pulmonary vein stump. Spontaneous echo contrast in the pulmonary vein stump was seen in three patients who underwent left upper lobectomy. Of the three patients with spontaneous echo contrast, two patients developed thrombosis in the left superior vein stump within 3 months after the operation. There was no patient who developed arterial infarction. CONCLUSIONS: In patients who underwent left upper lobectomy, intraoperative ultrasonography to evaluate blood flow and the presence of spontaneous echo contrast in the left superior pulmonary vein stump may be useful to predict thrombosis that may cause arterial infarction.
• Video-assisted thoracoscopic surgery using mobile computed tomography: new method for locating of small lung nodules.
  Kazuto Ohtaka, Yasuhiro Takahashi, Kichizo Kaga, Naoto Senmaru, Yoshihisa Kotani, Yoshiro Matsui
  Journal of cardiothoracic surgery, 9, 110, 110, 2014年06月20日, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: The O-arm is an intraoperative imaging device that can provide computed tomography images. Surgery for small lung tumors was performed based on intraoperative computed tomography images obtained using the O-arm. This study evaluated the usefulness of the O-arm in thoracic surgery. METHODS: From July 2013 to November 2013, 10 patients with small lung nodules or ground glass nodules underwent video-assisted thoracoscopic surgery using the O-arm. A needle was placed on the visceral pleura near the nodules. After the lung was re-expanded, intraoperative computed tomography was performed using the O-arm. Then, the positional relationship between the needle marking and the tumor was recognized based on the intraoperative computed tomography images, and lung resection was performed. RESULTS: In 9 patients, the tumor could be seen on intraoperative computed tomography images using the O-arm. In 1 patient with a ground glass nodule, the lesion could not be seen, but its location could be inferred by comparison between preoperative and intraoperative computed tomography images. In only 1 patient with a ground glass nodule, a pathological complete resection was not performed. There were no complications related to the use of the O-arm. CONCLUSIONS: The O-arm may be an additional tool to facilitate intraoperative localization and surgical resection of non-palpable lung lesions.
• Left lobectomy might be a risk factor for atrial fibrillation following pulmonary lobectomy.
  Yanzhong Xin, Yasuhiro Hida, Kichizo Kaga, Yasuaki Iimura, Nobuyuki Shiina, Kazuto Ohtaka, Jun Muto, Suguru Kubota, Yoshiro Matsui
  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 45, 2, 247, 50, 2014年02月, ［国際誌］
  英語, 研究論文（学術雑誌）, OBJECTIVE: To identify risk factors for atrial fibrillation (AF) following lobectomy for a pulmonary malignant tumour. METHODS: The outcomes of patients who underwent lobectomy from February 2005 to September 2010 were analysed with respect to the development of postoperative AF. RESULTS: Among 186 patients, 20 developed AF and these had significantly higher preoperative B-type natriuretic peptide (BNP) than those without AF. A significantly high incidence of AF following pulmonary lobectomy was demonstrated in the group of patients who were male, underwent a thoracotomy, had a high preoperative value of BNP and underwent a left lobectomy. Multivariate analysis revealed that left lobectomy is the only independent risk factor. The area under the receiver-operating characteristic curve for BNP to predict postoperative AF following a left lobectomy for a pulmonary malignant tumour was 0.82 (95% confidence interval 0.70-0.93; P<0.05). A BNP level of 24.1 pg/ml had a sensitivity of 90.9% and a specificity of 56% for predicting postoperative AF following left lobectomy for a pulmonary malignant tumour. CONCLUSIONS: Left lobectomy is the only independent risk factor for postoperative AF. Elevated BNP is the risk factor for postoperative AF in patients undergoing left pulmonary lobectomy.
• Use of maximum standardized uptake value on fluorodeoxyglucose positron-emission tomography in predicting lymph node involvement in patients with primary non-small cell lung cancer.
  Jun Muto, Yasuhiro Hida, Kichizo Kaga, Kazuto Ohtaka, Shozo Okamoto, Nagara Tamaki, Reiko Nakada-Kubota, Satoshi Hirano, Yoshiro Matsui
  Anticancer research, 34, 2, 805, 10, 2014年02月, ［国際誌］
  英語, 研究論文（学術雑誌）, AIM: Surgical resection is a standard therapeutic approach for some cases of non-small cell lung cancer (NSCLC). Fluorodeoxyglucose positron-emission tomography (FDG-PET) is now widely used in clinical diagnosis and staging of various types of cancers, including NSCLC. We investigated whether the maximum standardized uptake value (SUVmax) of primary tumors is useful in predicting the extent of lymph node involvement. PATIENTS AND METHODS: We retrospectively evaluated 354 patients with NSCLC who underwent surgery following FDG-PET and computed tomographic (CT) scans in our hospital. Logistic regression analyses were used to assess associations between categories (age, sex, tumor size, SUVmax, serum Squamous cell carcinoma-related antigen (SCC), cytokeratin 19 fragment (CYFRA), carcinoembryonic antigen (CEA), Brinkman index and histologic type. Differences in SUVmax of primary tumors between positive and negative lymph node involvement were examined by Mann-Whitney U-test. RESULTS: SUVmax of primary tumors in patients without lymph node involvement was significantly lower than in those with involvement, in both adenocarcinoma and squamous cell carcinomas (median, 2.2 vs. 4.9 in adenocarcinoma and 5.0 vs. 8.1 in squamous cell carcinoma, p<0.001 for both). Among node-positive cases, the lowest primary tumor SUVmax was 1.24 in an adenocarcinoma and 2.05 in a squamous cell carcinoma. However, primary tumor SUVmax and extent of lymph node metastases showed no significant differences between pN1 and pN2, single and multiple lymph node involvement, or single and multiple station involvement. CONCLUSION: A low primary tumor SUVmax in NSCLC may help identify patients with no lymph node involvement. However, SUVmax does not discriminate between minimal and extended lymph node involvement.
• Left upper lobectomy can be a risk factor for thrombosis in the pulmonary vein stump.
  Kazuto Ohtaka, Yasuhiro Hida, Kichizo Kaga, Yasuhiro Takahashi, Hiroshi Kawase, Satoshi Hayama, Tatsunosuke Ichimura, Naoto Senmaru, Naotake Honma, Yoshiro Matsui
  Journal of cardiothoracic surgery, 9, 5, 5, 2014年01月06日, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Thrombosis in the left upper pulmonary vein stump after left upper lobectomy is a very rare but important complication because it occurs in the systemic circulation system. We previously made the first ever report on the frequency and risk factors of thrombosis in the pulmonary vein stump after lobectomy. In this study, we conducted an investigation in a different hospital to determine whether this was a common complication. METHODS: From 2008 to 2012, 151 patients who underwent lobectomy and following enhanced CT within 2 years after the operation were studied. Postoperative contrast-enhanced CT imaging was retrospectively checked. RESULTS: We found thrombosis in the pulmonary vein stump in 5 of the 151 patients (3.3%). All 5 patients underwent left upper lobectomy (17.9% of the patients who underwent left upper lobectomy). These 5 patients did not have infarction of any vital organ. The thrombus was disappeared several months later on contrast-enhanced CT in 3 patients and followed in 2 patients. On univariate analysis, there was a significant difference only in the operative procedure (p<0.001). CONCLUSIONS: Thrombosis in the pulmonary vein stump occurred with high frequency in patients who underwent left upper lobectomy. Because the frequency of thrombosis in this study was the same as in our previous report, this might be a common complication.
• Outcome analysis of (18)F-fluorodeoxyglucose positron-emission tomography in patients with lung cancer after partial volume correction.
  Kazuto Ohtaka, Yasuhiro Hida, Kichizo Kaga, Shozo Okamoto, Tohru Shiga, Nagara Tamaki, Jun Muto, Reiko Nakada-Kubota, Satoshi Hirano, Yoshiro Matsui
  Anticancer research, 33, 11, 5193, 8, 2013年11月, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: This study aimed to evaluate the necessity for the partial volume effect (PVE) correction of the maximum standardized uptake value (SUVmax) in (18)F-fluorodeoxyglucose positron-emission tomography (FDG-PET) for predicting outcome in patients with non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: A total of 191 patients, with tumor diameters ranging from 10-37 mm, underwent pre-operative FDG-PET and curative resection. The SUVmax (Pre-SUV) of the primary tumor was corrected (Cor-SUV) using a recovery coefficient curve based on phantom experiments. RESULTS: The 5-year overall survival (OS) and disease-free survival (DFS) of the patients with high Pre-SUVs were lower than those with low Pre-SUVs (p<0.001 and p=0.002, respectively). The 5-year OS and DFS of patients with high Cor-SUVs were significantly lower than those with low Cor-SUVs (p<0.001 and p=0.005, respectively). CONCLUSION: Even without PVE correction, SUVmax was able to predict for outcome in patients with NSCLC.
• Reduced port video-assisted thoracoscopic surgery using a needle scope for lung and mediastinal lesions.
  Kichizo Kaga, Yasuhiro Hida, Reiko Nakada-Kubota, Kazuto Ohtaka, Jun Muto, Keidai Ishikawa, Tatsuya Kato, Yoshiro Matsui
  Interactive cardiovascular and thoracic surgery, 17, 2, 268, 72, 2013年08月, ［国際誌］
  英語, 研究論文（学術雑誌）, OBJECTIVES: There are many recent and minimally invasive surgical innovations, yet there has been little evaluation of the limitations of such techniques, particularly those related to video-assisted thoracoscopic surgery. The aims of this study were to determine the usefulness and limitations of video-assisted thoracoscopic surgery using one-port access and needle scope and to evaluate the feasibility of this procedure based on our institutional experience. METHODS: This retrospective study involved 127 patients who underwent video-assisted thoracoscopic surgery using the one-window and puncture method at our institute from 1997 to 2011. One hundred patients underwent surgical treatment and 27 underwent diagnostic procedures. If there was one lesion present with only mild adhesion that did not require lymph node dissection, we decided to opt for the one-direction approach that provisionally indicates the one-window and puncture method. We compared the conversion and success groups for factors like age, sex, laterality of surgery, objective of surgery, target organ and surgery location. RESULTS: Of 127 cases, 115 (91%) successfully underwent the one-window and puncture procedure. Twelve cases (9%) were converted to the two-window method or thoracotomy. Compared with those targeting the lung, patients with mediastinal lesions demonstrated a higher tendency for conversion (P<0.05). However, age (P=0.89), sex (P=0.46), laterality of surgery (P=0.34) and purpose of surgery (P=0.68) did not show any significant differences between the groups. CONCLUSIONS: For lung and mediastinal diseases, video-assisted thoracoscopic surgery with the one-window and puncture method can be performed at any location (upper, middle and lower lobe of lung and anterior, middle and posterior of the mediastinum) under limited indications that include the possibility of one-way resection, mild adhesion and no requirement of lymph node dissection. Under provisional criteria, the procedure may be feasible.
• 【肺手術後の合併症-発生予防と治療-】術後脳梗塞、心筋梗塞
  樋田 泰浩, 加賀 基知三, 大高 和人, 川田 将也, 久保田 卓, 松居 喜郎
  日本胸部臨床, 72, 7, 742, 753, 克誠堂出版(株), 2013年07月
  日本語, 研究論文（学術雑誌）, 脳梗塞と心筋梗塞はいずれも致死率の高い動脈塞栓症である。近年胸腔鏡手術の普及に伴い、触知困難な肺病変の部位同定のための経皮的穿刺マーキング手技による空気塞栓が問題になっている。最近、われわれは左肺上葉切除後に比較的高頻繁に肺静脈断端内に血栓が形成されることを見いだした。心房細動を伴わない脳梗塞は左上葉切除術や左肺全摘術後の報告例が多い。左上肺静脈断端内の血栓による動脈塞栓症はこれまで知られていなかったが、今後、多施設での検討が必要と思われる。(著者抄録)
• Thrombosis in the pulmonary vein stump after left upper lobectomy as a possible cause of cerebral infarction.
  Kazuto Ohtaka, Yasuhiro Hida, Kichizo Kaga, Tatsuya Kato, Jun Muto, Reiko Nakada-Kubota, Tsukasa Sasaki, Yoshiro Matsui
  The Annals of thoracic surgery, 95, 6, 1924, 8, 2013年06月, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Thrombus in the stump of the pulmonary vein (PV) is not a well-known complication after lung resection, and it has the potential to cause embolism to vital organs. To clarify the frequency, risk factors, and cause of this complication, a retrospective clinical study of patients who underwent lobectomy was performed. METHODS: The study evaluated 193 patients with primary lung cancer who underwent lobectomy from 2005 to 2011 and contrast-enhanced chest computed tomography (CT) within 2 years after lobectomy. Contrast-enhanced CT was retrospectively interpreted to check for thrombus in the PV stump. RESULTS: The operative procedures were 65 right upper lobectomies, 14 right middle lobectomies, 40 right lower lobectomies, 52 left upper lobectomies (LUL), and 22 left lower lobectomies. Thrombus developed in the PV stump in 7 of the 193 patients (3.6%) after lobectomy. All patients with thrombus had undergone LUL, and 13.5% of those who had undergone LUL developed thrombus. Univariate analyses revealed that LUL and operation time were significant risk factors and that adjuvant chemotherapy was marginally significant. It appears that thrombus may be attributable to the length of the PV stump. Measurement of the length of the PV stump using 3-dimensional CT images of the PV revealed that the stump of the left superior PV was longer than the others. CONCLUSIONS: Thrombus in the PV stump occurred in 13.5% of patients after LUL. These findings suggest that contrast-enhanced CT should be recommended for patients after LUL to help identify those with a high risk for thromboembolism.
• Limited resection and two-staged lobectomy for non-small cell lung cancer with ground-glass opacity.
  Kazuto Ohtaka, Yasuhiro Hida, Kichizo Kaga, Tatsuya Kato, Jun Muto, Reiko Nakada-Kubota, Satoshi Hirano, Yoshiro Matsui
  Journal of cardiothoracic surgery, 8, 111, 111, 2013年04月24日, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Lung tumors showing ground-glass opacities on high-resolution computed tomography indicate the presence of inflammation, atypical adenomatous hyperplasia, or localized bronchioloalveolar carcinoma. We adopted a two-staged video-assisted thoracoscopic lobectomy strategy involving completion lobectomy for localized bronchioloalveolar carcinoma with an invasive component according to postoperative pathological examination by permanent section after partial resection. METHODS: Forty-one patients with undiagnosed small peripheral ground-glass opacity lesions underwent partial resection from 2001 to 2007 in Hokkaido University Hospital. Localized bronchioloalveolar carcinoma was classified according to the Noguchi classification for adenocarcinoma. Malignant lesions other than Noguchi types A and B were considered for completion lobectomy and systemic mediastinal lymphadenectomy. Perioperative data of completion video-assisted thoracoscopic lobectomies were compared with data of 67 upfront video-assisted thoracoscopic lobectomies for clinical stage IA adenocarcinoma performed during the same period. RESULTS: Postoperative pathological examination revealed 35 malignant and 6 non-malignant diseases. Histologically, all of the malignant diseases were adenocarcinomas of Noguchi type A (n = 7), B (n = 9), C (n = 18), and F (n = 1). Eleven of 19 patients (58%) with Noguchi type C or F underwent two-staged video-assisted thoracoscopic lobectomy. Three patients refused a second surgery. There was no cancer recurrence. The two-staged lobectomy group had a significantly longer operative time and more blood loss than the upfront lobectomy group. There was no surgical mortality or cancer recurrence. CONCLUSIONS: Two-staged lobectomy for undiagnosed small peripheral ground-glass opacity lesions showed satisfactory oncological results. However, low compliance for and invasiveness of the second surgery are concerns associated with this strategy.
• 左上葉切除後の重要な合併症 左上肺静脈断端内血栓
  大高 和人, 高橋 康宏, 本間 直健, 川瀬 寛, 早馬 聡, 仙丸 直人, 樋田 泰浩, 加賀 基知三
  日本呼吸器外科学会雑誌, 27, 3, 378, 378, (NPO)日本呼吸器外科学会, 2013年04月
  日本語
• Video-assisted thoracoscopic left lower lobectomy in a patient with lung cancer and a right aortic arch.
  Hideyuki Wada, Yasuhiro Hida, Kichizo Kaga, Ryunosuke Hase, Kazuto Ohtaka, Jun Muto, Nakada-Kubota Reiko, Satoshi Hirano, Yoshiro Matsui
  Journal of cardiothoracic surgery, 7, 120, 120, 2012年11月13日, ［国際誌］
  英語, 研究論文（学術雑誌）, A right aortic arch is a rare congenital anomaly, with a reported incidence of around 0.1%. A patient with a right aortic arch underwent video-assisted thoracic surgery left lower lobectomy and mediastinal lymph node dissection for squamous cell carcinoma. There was no aortic arch or descending aorta in the left thoracic cavity, but the esophagus. There was no anomaly in the location or branching of the pulmonary vessels, the bronchi, and the lobulation of the lungs. The vagus nerve was found at the level of the left pulmonary artery. The arterial ligament was found between the left subclavian artery and the left pulmonary artery. The recurrent laryngeal nerve was recurrent around the left subclavian artery. A Kommerell diverticulum was found at the origin of the left subclavian artery. The patient experienced no complications. We conclude that video-assisted thoracoscopic lobectomy with mediastinal dissection is feasible for treating lung cancer with a right aortic arch.
• [Indication of video-assisted thoracic surgery for mediastinal mass lesions].
  Yasuhiro Hida, Jun Muto, Kichizo Kaga, Tatsuya Kato, Keidai Ishikawa, Reiko Nakada-Kubota, Kazuto Ohtaka, Yoshiro Matsui
  Kyobu geka. The Japanese journal of thoracic surgery, 65, 11, 934, 8, 2012年10月, ［国内誌］
  日本語, 研究論文（学術雑誌）, BACKGROUND: Most of mediastinal tumors are benign cysts and neoplasms. Resection is indicated for cystic lesions because of possibility of malignancy, compression symptom and possible rupture in future. However careful observation might be appropriate for asymptomatic tumors without risk of malignancy. Although video-assisted thoracoscopic surgery (VATS) is increasingly performed, its indication is still controversial. PATIENTS AND RESULTS: Among 37 mediastinal cystic lesions with confirmed pathological diagnosis, 17 were neoplasms. All of 20 non-neoplastic lesions have cyst wall thinner than 5 mm. Five cases( 29%) of neoplastic lesions have cyst wall thinner than 5 mm. Three of them underwent preoperative fluorodeoxyglucose-positron emission tomography( FDG-PET) or PET-computed tomography( CT). All 3 neoplastic lesions with thin wall showed accumulation of FDG. None of non-neoplastic cyst had FDG accumulation. Ninety-seven patients underwent surgical resection for mediastinal tumors. Out of 51 VATS, 2 were converted to open thoracotomy. One patient with thymoma had ipsilateral pleural recurrence after VATS. Tumor sizes of those 3 patients were larger than 7 cm. CONCLUSIONS: Cystic mediastinal tumor with wall thickness less than 5 mm and no FDG accumulation might be observed without resection because it is very unlikely to be a neoplasm. Mediastinal tumor larger than 7 cm might not be suitable for VATS.
• 完全胸腔鏡下気管支断端肋間筋弁被覆　　　　　　　　　　　　　　　
  樋田 泰浩, 加賀 基知三, 加藤 達哉, 井上 玲, 大高 和人, 武藤 潤, 武内 慎太郎, 松居 喜郎
  日本呼吸器外科学会雑誌, 26, 3, RS03, 02, (NPO)日本呼吸器外科学会, 2012年04月
  日本語
• 完全胸腔鏡下肺区域切除の適応、手技およびその成績　　　　　　　　　　　　　　　
  加賀 基知三, 樋田 泰浩, 加藤 達哉, 井上 玲, 大高 和人, 武藤 潤, 中田 玲子, 松居 喜郎
  日本呼吸器外科学会雑誌, 26, 3, RV10, 05, (NPO)日本呼吸器外科学会, 2012年04月
  日本語
• 原発性肺腺癌における術前血清CYFRA値と予後との関連に関する検討　　　　　　　　　　　　　　　
  武内 慎太郎, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 中田 玲子, 大高 和人, 武藤 潤, 井上 玲, 平野 聡, 松居 喜郎
  日本呼吸器外科学会雑誌, 26, 3, O02, 02, (NPO)日本呼吸器外科学会, 2012年04月
  日本語
• 肺癌術後脳血管障害の機序と対策 左上葉切除術は肺静脈断端内血栓の危険因子である　　　　　　　　　　　　　　　
  大高 和人, 樋田 泰浩, 加賀 基知三, 加藤 達哉, 井上 玲, 武藤 潤, 中田 玲子, 松居 喜郎
  日本呼吸器外科学会雑誌, 26, 3, O12, 01, (NPO)日本呼吸器外科学会, 2012年04月
  日本語
• 病理病期III悪性胸膜中皮腫切除症例の検討　　　　　　　　　　　　　　　
  中田 玲子, 樋田 泰浩, 加賀 基知三, 加藤 達哉, 井上 玲, 大高 和人, 武藤 潤, 平野 聡, 松井 喜郎
  日本呼吸器外科学会雑誌, 26, 3, O13, 05, (NPO)日本呼吸器外科学会, 2012年04月
  日本語
• 頸部切開と胸腔鏡操作で摘除し得た縦隔上部胸腺腫の一例　　　　　　　　　　　　　　　
  阿部 早和子, 樋田 泰浩, 加賀 基知三, 加藤 達哉, 大高 和人, 武藤 潤, 井上 玲, 中田 玲子, 松居 喜郎
  日本呼吸器外科学会雑誌, 26, 3, P45, 03, (NPO)日本呼吸器外科学会, 2012年04月
  日本語
• 原発巣へのFDG集積による非浸潤性非小細胞肺癌の判定　　　　　　　　　　　　　　　
  武藤 潤, 樋田 泰浩, 加賀 基知三, 加藤 達哉, 大高 和人, 井上 玲, 中田 玲子, 平野 聡, 松居 喜郎
  日本呼吸器外科学会雑誌, 26, 3, P16, 02, (NPO)日本呼吸器外科学会, 2012年04月, ［査読有り］
  日本語
• 局所進行肺癌に対する外科治療戦略 cStageIII非小細胞肺癌の治療成績
  長谷 龍之介, 大高 和人, 武藤 潤, 井上 玲, 樋田 泰浩, 加賀 基知三
  日本外科学会雑誌, 113, 臨増2, 211, 211, (一社)日本外科学会, 2012年03月
  日本語
• 非小細胞肺癌患者におけるSUV補正の有用性の検討
  大高 和人, 樋田 泰浩, 長谷 龍之介, 武藤 潤, 中田 玲子, 加賀 基知三, 松居 喜郎
  日本外科学会雑誌, 113, 臨増2, 591, 591, (一社)日本外科学会, 2012年03月
  日本語
• [Indication of limited pulmonary resection for small-sized lung cancer based on preoperative clinical data].
  Yasuhiro Hida, Koichi Teramura, Jun Muto, Kazuto Ohtaka, Ryunosuke Hase, Reiko Nakada, Yusuke Watanabe, Yoshiro Matsui, Kichizo Kaga
  Kyobu geka. The Japanese journal of thoracic surgery, 65, 1, 52, 7, 2012年01月, ［国内誌］
  日本語, 研究論文（学術雑誌）, Limited pulmonary resection is performed mostly based on the size of lung cancer and ground-glass opacity (GGO). It has been proposed to determine the indication of segmentectomy according to hilar lymph node involvement. There is a potential risk of underestimation for lymph node involvement since there may be a skip mediastinal lymph node metastasis without hilar involvement. We propose to use standardized uptake value( SUV) max of primary lung cancer as an indicator of non-invasive lung cancer. None of 44 small-sized lung cancers with SUVmax lower than 1 had lymph node metastasis or vessel invasion. A small-sized lung cancer ≤ 2 cm with SUVmax ≤ 1 is indicated wedge resection if GGO area is greater than 75% of tumor. Segmentectomy is indicated if the GGO area is less than 75%. We also propose selective lymphadenectomy for small-sized lung cancer. The lower mediastinal lymphadenectomy may be omitted if a small-sized tumor is located in the right upper lobe or the left upper segment. The upper mediastinal lymphadenectomy may be omitted if a small-sized lung cancer is located in the lower lobe and if the lower mediastinal lymph node involvement is excluded.
• Pulmonary vein thrombosis after video-assisted thoracoscopic left upper lobectomy.
  Kazuto Ohtaka, Yasuhiro Hida, Kichizo Kaga, Yasuaki Iimura, Nobuyuki Shiina, Jun Muto, Satoshi Hirano
  The Journal of thoracic and cardiovascular surgery, 143, 1, e3-5, 2012年01月, ［国際誌］
  英語, 研究論文（学術雑誌）
• 放射線療法後肺切除術の局所効果および安全性
  加賀 基知三, 樋田 泰浩, 長谷 龍之介, 中田 玲子, 大高 和人, 武藤 潤, 平野 聡
  肺癌, 51, 7, 845, 846, (NPO)日本肺癌学会, 2011年12月
  日本語
• 縦隔腫瘍に対する腫瘍マーカーの意義
  武藤 潤, 樋田 泰浩, 加賀 基知三, 中田 玲子, 大高 和人, 長谷 龍之介, 平野 聡
  肺癌, 51, 7, 844, 845, (NPO)日本肺癌学会, 2011年12月
  日本語
• 原発性肺癌に対する胸腔鏡下手術開胸移行例の検討
  長谷 龍之介, 和田 秀之, 高坂 琢磨, 中田 玲子, 大高 和人, 武藤 潤, 樋田 泰浩, 加賀 基知三, 平野 聡
  北海道外科雑誌, 56, 2, 162, 162, 北海道外科学会, 2011年12月
  日本語
• 術後3年9ヵ月無再発生存中の悪性胸膜中皮腫pT3N2M0の1例
  中田 玲子, 樋田 泰浩, 加賀 基知三, 長谷 龍之介, 大高 和人, 武藤 潤, 平野 聡
  肺癌, 51, 7, 846, 846, (NPO)日本肺癌学会, 2011年12月
  日本語
• 日本呼吸器外科学会北海道地区胸腔鏡手術セミナーにおけるトレーニング効果
  飯村 泰昭, 加賀 基知三, 樋田 泰浩, 椎名 伸行, 大高 和人, 武藤 潤, 加地 苗人, 渡辺 敦, 近藤 啓史, 近藤 哲
  日本呼吸器外科学会雑誌 = The journal of the Japanese Association for Chest Surgery, 25, 7, 714, 718, 2011年11月15日
  日本語
• 低侵襲手術の功罪 胸腔鏡下手術における触知困難肺腫瘍の同定と切除マージンの確認
  樋田 泰浩, 加賀 基知三, 長谷 龍之介, 大高 和人, 武藤 潤, 中田 玲子, 和田 秀之, 高坂 琢磨, 品川 尚文, 平野 聡
  肺癌, 51, 5, 367, 367, (NPO)日本肺癌学会, 2011年10月
  日本語
• 胸水細胞診、胸腔内洗浄細胞診(PLC)陽性肺癌の術前予測因子の検討
  和田 秀之, 加賀 基知三, 樋田 泰浩, 長谷 龍之介, 大高 和人, 武藤 潤, 中田 玲子, 高坂 琢磨, 平野 聡
  肺癌, 51, 5, 413, 413, (NPO)日本肺癌学会, 2011年10月
  日本語
• 転移性肺腫瘍の予後予測因子としての、FDG-PETにおけるSUVの有用性の検討
  中田 玲子, 加賀 基知三, 樋田 泰浩, 長谷 龍之介, 武藤 潤, 大高 和人, 平野 聡
  肺癌, 51, 5, 429, 429, (NPO)日本肺癌学会, 2011年10月
  日本語
• 当院における縦隔腫瘍の治療方針
  武藤 潤, 樋田 泰浩, 加賀 基知三, 長谷 龍之介, 大高 和人, 中田 玲子, 平野 聡
  肺癌, 51, 5, 428, 428, (NPO)日本肺癌学会, 2011年10月
  日本語
• 小児外科における内視鏡下手術の現状 6歳未満の小児患者に対する胸腔鏡手術の工夫
  大高 和人, 樋田 泰浩, 加賀 基知三, 長谷 龍之介, 武藤 潤, 中田 玲子, 平野 聡
  日本臨床外科学会雑誌, 72, 増刊, 414, 414, 日本臨床外科学会, 2011年10月
  日本語
• 術後気管支断端瘻症例の検討
  長谷 龍之介, 和田 秀之, 高坂 琢磨, 中田 玲子, 大高 和人, 武藤 潤, 樋田 泰浩, 加賀 基知三
  日本臨床外科学会雑誌, 72, 増刊, 746, 746, 日本臨床外科学会, 2011年10月
  日本語
• 経験から学ぶ内視鏡下手術のトラブルシューティング(肺) 完全胸腔鏡下手術の出血に対する段階的対処法
  長谷 龍之介, 和田 秀之, 高坂 琢磨, 中田 玲子, 大高 和人, 武藤 潤, 樋田 泰浩, 加賀 基知三, 平野 聡
  日本臨床外科学会雑誌, 72, 増刊, 344, 344, 日本臨床外科学会, 2011年10月
  日本語
• 非小細胞肺癌原発腫瘍のFDG‐PETのSUVを基準とした選択的縦隔リンパ節郭清
  武藤潤, 樋田泰浩, 加賀基知三, 大高和人, 寺村紘一, 椎名伸行, 飯村泰昭, 平野聡, 近藤哲
  日本外科学会雑誌, 112, 臨増1-2, 365, 365, (一社)日本外科学会, 2011年05月25日
  日本語
• 三次元再構築CT画像(3D-CT)による肺動静脈分枝様式の検討
  椎名 伸行, 加賀 基知三, 樋田 泰浩, 飯村 泰昭, 大高 和人, 武藤 潤, 中田 玲子, 平野 聡, 近藤 哲
  日本外科学会雑誌, 112, 臨増1-2, 642, 642, (一社)日本外科学会, 2011年05月
  日本語
• 小児に対する胸腔鏡手術の経験
  加賀 基知三, 樋田 泰浩, 飯村 泰昭, 椎名 伸行, 武藤 潤, 大高 和人, 中田 玲子, 平野 聡, 近藤 哲
  日本外科学会雑誌, 112, 臨増1-2, 495, 495, (一社)日本外科学会, 2011年05月
  日本語
• 肺がんに対する縮小手術と拡大手術 術前臨床データを駆使した合理的な縮小手術 完全胸腔鏡下肺区域切除術の適応と手技
  樋田 泰浩, 加賀 基知三, 飯村 泰昭, 椎名 伸行, 大高 和人, 武藤 潤, 寺村 紘一, 平野 聡, 近藤 哲
  日本外科学会雑誌, 112, 臨増1-2, 325, 325, (一社)日本外科学会, 2011年05月
  日本語
• T因子決定法の問題点 すりガラス(GGO)病変の計測について
  飯村 泰昭, 加賀 基知三, 樋田 泰浩, 黒田 晶, 椎名 信行, 大高 和人, 武藤 潤, 中田 玲子, 平野 聡, 近藤 哲
  日本外科学会雑誌, 112, 臨増1-2, 362, 362, (一社)日本外科学会, 2011年05月
  日本語
• 原発腫瘍のmaxSUVによる非小細胞肺癌切除後の再発時期の予測
  大高 和人, 加賀 基知三, 樋田 泰浩, 飯村 泰昭, 椎名 伸行, 武藤 潤, 中田 玲子, 平野 聡, 近藤 哲
  日本外科学会雑誌, 112, 臨増1-2, 643, 643, (一社)日本外科学会, 2011年05月
  日本語
• 局所進行肺癌に対する術前化学放射線療法後の肺切除およびサルベージ手術
  加賀 基知三, 樋田 泰浩, 飯村 泰昭, 椎名 伸行, 大高 和人, 武藤 潤, 平野 聡, 近藤 哲
  日本呼吸器外科学会雑誌, 25, 3, V14, 03, (NPO)日本呼吸器外科学会, 2011年04月
  日本語
• 胸腔鏡手術の適応と限界 理想の低侵襲肺癌手術、完全胸腔鏡下肺区域切除と縦隔リンパ節郭清
  樋田 泰浩, 加賀 基知三, 飯村 泰昭, 椎名 伸行, 大高 和人, 武藤 潤, 平野 聡, 近藤 哲
  日本呼吸器外科学会雑誌, 25, 3, SY2, 02, (NPO)日本呼吸器外科学会, 2011年04月
  日本語
• 腺癌縮小手術適応基準としてのPET検査SUV値の可能性
  飯村 泰昭, 加賀 基知三, 樋田 泰浩, 椎名 伸行, 大高 和人, 武藤 潤, 新田 健雄, 平野 聡, 近藤 哲
  日本呼吸器外科学会雑誌, 25, 3, O32, 07, (NPO)日本呼吸器外科学会, 2011年04月
  日本語
• 肺葉切除後に発症した肺静脈断端内血栓の3例
  大高 和人, 加賀 基知三, 樋田 泰浩, 飯村 泰昭, 椎名 伸行, 武藤 潤, 平野 聡, 近藤 哲
  日本呼吸器外科学会雑誌, 25, 3, P84, 02, (NPO)日本呼吸器外科学会, 2011年04月
  日本語
• PET、PET-CTを併用した縦隔嚢胞性病変の診断
  武藤 潤, 樋田 泰浩, 加賀 基知三, 大高 和人, 椎名 伸行, 飯村 泰昭, 平野 聡, 近藤 哲
  肺癌, 50, 7, 948, 948, (NPO)日本肺癌学会, 2010年12月
  日本語
• 術前三次元再構築CT(3D-CT)を用いた肺静脈の評価
  椎名 伸行, 加賀 基知三, 大高 和人, 武藤 潤, 飯村 泰昭, 樋田 泰浩, 平野 聡, 近藤 哲
  北海道外科雑誌, 55, 2, 186, 186, 北海道外科学会, 2010年12月
  日本語
• 悪性胸膜中皮腫切除症例の検討
  飯村 泰昭, 加賀 基知三, 樋田 泰浩, 椎名 伸行, 大高 和人, 武藤 潤, 中田 玲子, 平野 聡, 近藤 哲
  肺癌, 50, 7, 949, 949, (NPO)日本肺癌学会, 2010年12月
  日本語
• 局所進行肺癌に対する化学放射線療法、術前導入療法、根治的治療後局所再発切除あるいは"Adjuvant surgery"
  樋田 泰浩, 加賀 基知三, 飯村 泰昭, 椎名 伸行, 大高 和人, 武藤 潤, 岡村 国茂, 平野 聡, 近藤 哲
  肺癌, 50, 5, 577, 577, (NPO)日本肺癌学会, 2010年10月
  日本語
• 二窓法による完全胸腔鏡下肺区域切除について
  加賀 基知三, 樋田 泰浩, 大高 和人, 武藤 潤, 椎名 伸行, 飯村 泰昭, 近藤 哲
  肺癌, 50, 5, 571, 571, (NPO)日本肺癌学会, 2010年10月
  日本語
• 外科におけるバーチャル画像の有用性と限界 呼吸器外科領域における術前三次元再構築CT(3D-CT)の有用性と限界の検討
  椎名 伸行, 加賀 基知三, 大高 和人, 武藤 潤, 飯村 泰昭, 樋田 泰浩, 平野 聡, 近藤 哲
  日本臨床外科学会雑誌, 71, 増刊, 381, 381, 日本臨床外科学会, 2010年10月
  日本語
• 胸腔鏡手術における安全対策 ヒト胸郭モデルによる段階的胸腔鏡手術トレーニング
  飯村 泰昭, 岡村 国茂, 大高 和人, 武藤 潤, 椎名 伸行, 樋田 泰浩, 加賀 基知三, 平野 聡, 近藤 哲
  日本臨床外科学会雑誌, 71, 増刊, 361, 361, 日本臨床外科学会, 2010年10月
  日本語
• 胸腔鏡手術の標準化にむけて 三次元再構築CTによる区域解剖にもとづく胸腔鏡手術の標準化　　　　　　　　　　　　　　　
  加賀 基知三, 樋田 泰浩, 飯村 泰昭, 椎名 伸行, 大高 和人, 武藤 潤, 平野 聡, 近藤 哲
  日本内視鏡外科学会雑誌, 15, 7, 281, 281, (一社)日本内視鏡外科学会, 2010年10月
  日本語
• 胸腔鏡下で存在部位の同定困難な肺小腫瘤に対する術前マーキング法 ゴールドマーカーを用いた仮想内視鏡ナビゲーション下術前マーキング法　　　　　　　　　　　　　　　
  大高 和人, 加賀 基知三, 樋田 泰浩, 飯村 泰昭, 椎名 伸行, 武藤 潤, 岡村 国茂, 平野 聡, 近藤 哲
  日本内視鏡外科学会雑誌, 15, 7, 294, 294, (一社)日本内視鏡外科学会, 2010年10月
  日本語
• 二窓法による胸腔鏡下縦隔リンパ節郭清における視点・展開・操作　　　　　　　　　　　　　　　
  加賀 基知三, 樋田 泰浩, 飯村 泰昭, 椎名 伸行, 大高 和人, 武藤 潤, 平野 聡, 近藤 哲
  日本内視鏡外科学会雑誌, 15, 7, 652, 652, (一社)日本内視鏡外科学会, 2010年10月
  日本語
• 原発性肺腺癌におけるdoubling timの算出法と臨床的意義の検討
  岡村 国茂, 樋田 泰浩, 加賀 基知三, 飯村 泰昭, 椎名 伸行, 大高 和人, 武藤 潤, 平野 聡, 近藤 哲
  日本臨床外科学会雑誌, 71, 増刊, 634, 634, 日本臨床外科学会, 2010年10月
  日本語
• 当科における乳頭部腫瘍に対する治療戦略　　　　　　　　　　　　　　　
  大高 和人, 田中 栄一, 土川 貴裕, 加藤 健太郎, 川崎 亮輔, 松本 譲, 松井 あや, 川村 武史, 平野 聡, 近藤 哲
  日本消化器外科学会総会, 65回, 552, 552, (一社)日本消化器外科学会, 2010年07月
  日本語
• 高度局所進行胆道癌に対する治療戦略 肝動脈・門脈合併切除再建を伴う肝切除　　　　　　　　　　　　　　　
  松井 あや, 田中 栄一, 平野 聡, 川村 武史, 斉藤 博紀, 中山 智英, 安孫子 剛大, 大高 和人, 近藤 哲
  日本消化器外科学会総会, 65回, 43, 43, (一社)日本消化器外科学会, 2010年07月
  日本語
• 【外科治療のトピックス 肺区域切除術】
  加賀 基知三, 樋田 泰浩, 椎名 伸行, 大高 和人, 武藤 潤, 飯村 泰昭, 平野 聡, 近藤 哲
  北海道外科雑誌, 55, 1, 2, 6, 北海道外科学会, 2010年06月
  日本語, 肺癌に対する縮小手術、第二肺癌や多発癌、転移性肺腫瘍に対する複数回手術として、根治性と機能温存を併せた肺区域切除の役割は大きい。肺悪性腫瘍に対する積極的縮小手術としての区域切除において、適応上の問題(病期、Ground Glass Opacity(GGO)率、腫瘍径、野口分類など)、根治性の確保の問題(切離断端距離の確保、リンパ郭清の有無など)や手技上の問題(胸腔鏡か開胸か、解剖学的か非解剖学的か、区域面や血管の同定、エアリーク対策など)などが論点となっている。肺区域の解剖や切除の手術手技は呼吸器外科医の基本として習得しておく必要がある。(著者抄録)
• 急性膵炎・慢性膵炎の外科治療 急性膵炎に対する鏡視下手術の経験　　　　　　　　　　　　　　　
  安孫子 剛大, 田中 栄一, 大高 和人, 川村 武史, 齋藤 博紀, 中山 智英, 三浦 巧, 松井 あや, 加藤 健太郎, 川崎 亮輔, 松本 譲, 土川 貴裕, 平野 聡, 近藤 哲
  日本肝胆膵外科学会・学術集会プログラム・抄録集, 22回, 212, 212, (一社)日本肝胆膵外科学会, 2010年05月
  日本語
• 膵頭十二指腸切除に伴う門脈再建方法と成績　　　　　　　　　　　　　　　
  大高 和人, 田中 栄一, 七戸 俊明, 土川 貴裕, 加藤 健太郎, 川崎 亮輔, 松本 譲, 松井 あや, 川村 武史, 斎藤 博紀, 三浦 巧, 中山 智英, 安孫子 剛大, 平野 聡, 近藤 哲
  日本肝胆膵外科学会・学術集会プログラム・抄録集, 22回, 202, 202, (一社)日本肝胆膵外科学会, 2010年05月
  日本語
• 巨大肝血管腫に対する肝右3区域切除の経験　　　　　　　　　　　　　　　
  寺村 紘一, 田中 栄一, 安孫子 剛大, 大高 和人, 川村 武史, 斉藤 博紀, 中山 智英, 松井 あや, 加藤 健太郎, 川崎 亮輔, 松本 譲, 土川 貴裕, 七戸 俊明, 平野 聡, 近藤 哲
  日本肝胆膵外科学会・学術集会プログラム・抄録集, 22回, 263, 263, (一社)日本肝胆膵外科学会, 2010年05月
  日本語
• 膵低悪性度病変に対する膵中央切除　　　　　　　　　　　　　　　
  松井 あや, 田中 栄一, 平野 聡, 七戸 俊明, 土川 貴裕, 加藤 健太郎, 川崎 亮輔, 松本 譲, 川村 武史, 斉藤 博紀, 中山 智英, 安孫子 剛大, 大高 和人, 近藤 哲
  日本肝胆膵外科学会・学術集会プログラム・抄録集, 22回, 195, 195, (一社)日本肝胆膵外科学会, 2010年05月
  日本語
• 非小細胞肺癌術後再発形式と時期の検討
  大高 和人, 加賀 基知三, 樋田 泰浩, 三栖 賢次郎, 椎名 伸行, 安孫子 剛大, 平野 聡, 近藤 哲
  肺癌, 49, 7, 1057, 1058, (NPO)日本肺癌学会, 2009年12月
  日本語
• 根治的化学放射線療法後の再発・異時性多発肺癌に対して肺葉切除と気管支断端大網被覆を行った4例
  樋田 泰浩, 加賀 基知三, 三栖 賢次郎, 椎名 伸行, 大高 和人, 安孫子 剛大, 平野 聡, 近藤 哲
  肺癌, 49, 7, 1057, 1057, (NPO)日本肺癌学会, 2009年12月
  日本語
• I期肺癌に対する胸腔鏡下区域切除術 肺癌に対する胸腔鏡下区域切除について　　　　　　　　　　　　　　　
  加賀 基知三, 樋田 泰浩, 三栖 賢次郎, 椎名 伸行, 安孫子 剛大, 大高 和人, 平野 聡, 近藤 哲
  日本内視鏡外科学会雑誌, 14, 7, 215, 215, (一社)日本内視鏡外科学会, 2009年12月
  日本語
• 原発性肺癌に対する胸腔鏡下肺切除術の長期成績　　　　　　　　　　　　　　　
  三栖 賢次郎, 加賀 基知三, 樋田 泰浩, 椎名 伸行, 安孫子 剛大, 大高 和人, 平野 聡, 近藤 哲
  日本内視鏡外科学会雑誌, 14, 7, 507, 507, (一社)日本内視鏡外科学会, 2009年12月
  日本語
• 転移性肺腫瘍に対する胸腔鏡下手術の検討　　　　　　　　　　　　　　　
  安孫子 剛大, 加賀 基知三, 樋田 泰浩, 三栖 賢次郎, 椎名 伸行, 大高 和人, 平野 聡, 近藤 哲
  日本内視鏡外科学会雑誌, 14, 7, 509, 509, (一社)日本内視鏡外科学会, 2009年12月
  日本語
• 術前induction治療後の手術手技 放射線治療後肺切除術における血管剥離および気管支断端の被覆について
  加賀 基知三, 樋田 泰浩, 三栖 賢次郎, 椎名 伸行, 安孫子 剛大, 大高 和人, 平野 聡, 近藤 哲
  肺癌, 49, 5, 574, 574, (NPO)日本肺癌学会, 2009年10月
  日本語
• 非小細胞肺癌術後再発形式と時期の検討
  大高 和人, 加賀 基知三, 樋田 泰浩, 三栖 賢次郎, 椎名 伸行, 我孫子 剛大, 平野 聡, 近藤 哲
  日本臨床外科学会雑誌, 70, 増刊, 514, 514, 日本臨床外科学会, 2009年10月
  日本語
• How I do it?肺切離 完全鏡視下肺区域切除の手技および工夫
  加賀 基知三, 樋田 泰浩, 安孫子 剛大, 大高 和人, 椎名 伸行, 三栖 賢次郎, 平野 聡, 近藤 哲
  日本臨床外科学会雑誌, 70, 増刊, 346, 346, 日本臨床外科学会, 2009年10月
  日本語
• 外科におけるバーチャル画像の有用性と限界 3D-CTによる肺区域切除と肺葉切除の手術ナビゲーション
  椎名 伸行, 加賀 基知三, 樋田 泰浩, 三栖 賢二郎, 安孫子 剛大, 大高 和人, 平野 聡, 近藤 哲
  日本臨床外科学会雑誌, 70, 増刊, 361, 361, 日本臨床外科学会, 2009年10月
  日本語