論文

• 前立腺DWIへのモデルベース深層学習下画像再構成の応用　　　　　　　　　　　　　　　
  西岡 典子, 藤間 憲幸, 常田 慧徳, 吉川 仁人, 木村 理奈, 坂本 圭太, 加藤 扶美, 松本 隆児, 権 池勲, 米山 正己, 工藤 與亮
  日本医学放射線学会秋季臨床大会抄録集, 60回, S417, S417, (公社)日本医学放射線学会, 2024年09月
  日本語
• 術前検査で偶発的に発見されたMinute pulmonary meningothelial-like nodulesの1例　　　　　　　　　　　　　　　
  小林 圭太, 吉川 仁人, 高柳 歩, 常田 慧徳, 中川 純一, 木村 理奈, 西岡 典子, 坂本 圭太, 加藤 扶美, 岡崎 ななせ, 松野 吉宏, 氏家 秀樹, 工藤 與亮
  北海道放射線医学雑誌, 4, 25, 29, (NPO)メディカルイメージラボ, 2024年03月
  日本語
• 低血糖発作を合併した胸膜孤立性線維性腫瘍の1例　　　　　　　　　　　　　　　
  村本 朋之, 中川 純一, 常田 慧徳, 高橋 文也, 木村 理奈, 西岡 典子, 坂本 圭太, 加藤 扶美, 氏家 秀樹, 加藤 達哉, 大藤 悠里, 亀田 啓, 中村 昭伸, 若林 健人, 松野 吉宏, 工藤 與亮
  Japanese Journal of Radiology, 42, Suppl., 4, 4, (公社)日本医学放射線学会, 2024年02月
  日本語
• 低血糖発作を合併した胸膜孤立性線維性腫瘍の1例　　　　　　　　　　　　　　　
  村本 朋之, 中川 純一, 常田 慧徳, 高橋 文也, 木村 理奈, 西岡 典子, 坂本 圭太, 加藤 扶美, 氏家 秀樹, 加藤 達哉, 大藤 悠里, 亀田 啓, 中村 昭伸, 若林 健人, 松野 吉宏, 工藤 與亮
  Japanese Journal of Radiology, 42, Suppl., 4, 4, (公社)日本医学放射線学会, 2024年02月
  日本語
• Clinical utility of single-shot echo-planar diffusion-weighted imaging using L1-regularized iterative sensitivity encoding in prostate MRI.
  Noriko Nishioka, Noriyuki Fujima, Satonori Tsuneta, Masami Yoneyama, Ryuji Matsumoto, Takashige Abe, Rina Kimura, Keita Sakamoto, Fumi Kato, Kohsuke Kudo
  Medicine, 102, 17, e33639, 2023年04月25日, ［国際誌］
  英語, 研究論文（学術雑誌）, We investigated the ability of echo-planar imaging with L1-regularized iterative sensitivity encoding-based diffusion-weighted imaging (DWI) to improve the image quality and reduce the scanning time in prostate magnetic resonance imaging. We retrospectively analyzed 109 cases of prostate magnetic resonance imaging. We compared variables in the quantitative and qualitative assessments among 3 imaging groups: conventional parallel imaging-based DWI (PI-DWI) with an acquisition time of 3 minutes 15 seconds; echo-planar imaging with L1-regularized iterative sensitivity encoding-based DWI (L1-DWI) with a normal acquisition time (L1-DWINEX12) of 3 minutes 15 seconds; and L1-DWI with a half acquisition time (L1-DWINEX6) of 1 minute 45 seconds. As a quantitative assessment, the signal-to-noise ratio (SNR) of DWI (SNR-DWI), the contrast-to-noise ratio (CNR) of DWI (CNR-DWI), and the CNR of apparent diffusion coefficient were measured. As a qualitative assessment, the image quality and visual detectability of prostate carcinoma were evaluated. In the quantitative analysis, L1-DWINEX12 showed significantly higher SNR-DWI than PI-DWI (P = .0058) and L1-DWINEX6 (P < .0001). In the qualitative analysis, the image quality score for L1-DWINEX12 was significantly higher than those of PI-DWI and L1-DWINEX6. A non-inferiority assessment demonstrated that L1-DWINEX6 was non-inferior to PI-DWI in terms of both quantitative CNR-DWI and qualitative grading of image quality with a <20% inferior margin. L1-DWI successfully demonstrated a reduced scanning time while maintaining good image quality.
• 胸膜孤立性線維性腫瘍に合併したDoege-potter症候群の一例　　　　　　　　　　　　　　　
  村本 朋之, 中川 純一, 常田 慧徳, 高橋 文也, 木村 理奈, 西岡 典子, 坂本 圭太, 加藤 扶美, 氏家 秀樹, 加藤 達哉, 大藤 悠理, 亀田 啓, 中村 昭伸, 若林 健人, 松野 吉宏, 工藤 與亮
  北海道放射線医学雑誌, 3, 28, 32, (NPO)メディカルイメージラボ, 2023年03月
  日本語
• Rheumatologic manifestations with elevated levels of IL-6, IL-17A, and IL-23 in a patient with scurvy
  Masahiro Ueki, Keita Sakamoto, Noriko Nishioka, Hiroki Ohata, Takiko Nobuta, Shunichiro Takezaki, Atsushi Manabe, Masafumi Yamada
  Modern Rheumatology Case Reports, Oxford University Press (OUP), 2022年08月09日
  研究論文（学術雑誌）, ABSTRACT
  
  Symptomatic vitamin C deficiency, scurvy, is a relatively rare disease in developed countries, but it has been reported in patients with autism spectrum disorder or developmental delay who tend to have selective diets. Patients with scurvy often demonstrate musculoskeletal manifestations with unknown pathophysiology. Herein, we report a case of scurvy in an 11-year-old boy who presented with iron-deficiency anaemia, systemic osteomyelitis, myositis predominantly in the lower extremities, and right ventricular volume overload with mild pulmonary hypertension and was diagnosed with scurvy. He had a mild developmental disorder and a selective diet, which resulted in severe vitamin C deficiency. He received intravenous and oral vitamin C supplementation, which relieved his arthralgia and muscle pain in a week. Following 4 months of vitamin C supplementation, he demonstrated no abnormal manifestations on laboratory or imaging examination and recovered without sequelae. Inflammatory cytokine and chemokine evaluations demonstrated elevated levels of interleukin (IL)-6, IL-17A, and IL-23, which are associated with T-helper (Th) 17 cell activation. This study is the first to suggest the association between the inflammation seen in scurvy, rheumatic manifestations in the patient, and Th17 cell activation. Further analysis of the association between the inflammation and vitamin C supplementation may contribute to new insights for the comprehension and treatment of other inflammatory diseases, such as rheumatic diseases.
• 腫瘍性骨軟化症に対してブロスマブを使用した3例
  宮崎 あすか, 亀田 啓, 大江 悠希, 泉原 里美, 重沢 郁美, 野本 博司, 曹 圭龍, 中村 昭伸, 坂本 圭太, 森田 亮, 曽山 武士, 阿保 大介, 工藤 與亮, 三好 秀明, 渥美 達也
  日本内分泌学会雑誌, 97, 2, 521, 521, (一社)日本内分泌学会, 2021年10月
  日本語
• Favorable Effects of Burosumab on Fibroblast Growth Factor 23-Related Osteomalacia: A Case Report
  Yuki Oe, Hiraku Kameda, Hiroshi Nomoto, Keita Sakamoto, Takeshi Soyama, Kyu Yong Cho, Akinobu Nakamura, Daisuke Abo, Kohsuke Kudo, Tatsuya Atsumi, Hideaki Miyoshi
  Journal of the Endocrine Society, 5, Supplement_1, A194, A194, The Endocrine Society, 2021年05月03日
  研究論文（学術雑誌）,
  Background: Fibroblast growth factor 23 (FGF23) decreases serum phosphate levels by inhibiting proximal tubular phosphate reabsorption and intestinal phosphate absorption by decreasing serum 1,25-dihydroxyvitamin D level, thereby regulating phosphate metabolism. Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by FGF23 overproduction by tumor tissue. Resecting the responsible tumor is a radical treatment for TIO. When the responsible tumor is undetectable, phosphate and active vitamin D administration is recommended. However, supplementation alone is frequently insufficient to maintain phosphate levels and it is difficult to prevent the complications associated with medical therapy, including hypercalciuria and nephrocalcinosis. Recently, burosumab, a human monoclonal anti-FGF23 antibody, has been approved in Japan as a therapeutic agent for FGF23-related hypophosphatemia. Here, we present a patient with TIO effectively treated with burosumab in the absence of identification of tumour location. Clinical case: A 47-year-old female developed pain and edema of the feet; however, the cause could not be determined at local hospitals. Afterwards, she developed marked bone atrophy in the feet and was referred to our hospital. Her age at symptom onset, hypophosphatemia (serum P, 1.9 mg/dl, 2.7 mg/dl &lt; n &lt; 4.6 mg/dl), high serum FGF23 level (630 pg/ml, 16 pg/ml &lt; n &lt; 69 pg/ml), and decreased 1,25-dihydroxyvitamin D level (12.9 pg/ml, 20 pg/ml &lt; n &lt; 60 pg/ml) indicated FGF23-related osteomalacia. She was not having any medication at the time of diagnosis, including saccharified iron oxide or iron polymaltose. Urinary phosphate excretion increased without renal tubular defect; therefore, hypophosphatemic osteomalacia was diagnosed. MRI showed high signal intensity in the talus, sacral, and L5 vertebral regions, indicating multiple pseudofractures. Comprehensive imaging studies, including systemic CT scan and 111In-pentetreotide scintigraphy, did not reveal any tumors despite the suspicion of TIO. Next, we performed systemic venous sampling, which revealed high FGF23 level in the left external iliac vein. Second venous sampling limited to the left lower limb exhibited high FGF23 level in the posterior tibial vein. However, an additional imaging study limited to the left foot could not identify any tumors. Genetic variation was negative for potentially responsible genes, including PHEX and FGF23. We decided to administer burosumab to normalize serum phosphate level without phosphate supplementation. Within 2 months, pain was relieved and the visual analog scale scores also improved from 10 to 6. Moreover, bone MRI showed improved pseudofractures. Conclusion: Burosumab administration was effective for TIO of unknown origin, and it improved not only laboratory findings but also clinical symptoms in this case.
• 全身MRI・骨シンチを用いた特発性大腿骨頭壊死症患者の多発骨壊死の評価
  横田 隼一, 清水 智弘, 坂本 圭太, 清水 幸衣, 浅野 毅, 高橋 大介, 工藤 與亮, 岩崎 倫政
  日本整形外科学会雑誌, 95, 3, S968, S968, (公社)日本整形外科学会, 2021年03月
  日本語
• 全身MRI・骨シンチを用いた特発性大腿骨頭壊死症患者の多発骨壊死の評価　　　　　　　　　　　　　　　
  横田 隼一, 清水 智弘, 坂本 圭太, 清水 幸衣, 中村 夢志郎, 高橋 要, 浅野 毅, 高橋 大介, 工藤 與亮, 岩崎 倫政
  日本リウマチ学会北海道・東北支部学術集会抄録集, 30回, 57, 57, (一社)日本リウマチ学会-北海道・東北支部, 2021年02月
  日本語
• 全身MRI・骨シンチを用いた特発性大腿骨頭壊死症患者の多発骨壊死の評価
  横田 隼一, 清水 智弘, 浅野 毅, 高橋 大介, 岩崎 倫政, 坂本 圭太, 清水 幸衣, 工藤 與亮
  北海道整形災害外科学会雑誌, 63, 139th suppl, 92, 92, 北海道整形災害外科学会, 2021年
  日本語
• 抗FGF23抗体が奏功したFGF23関連低リン血症性骨軟化症の一例
  大江 悠希, 亀田 啓, 家坂 光, 泉原 里美, 上垣 里紗, 亀田 玲奈, 野本 博司, 坂本 圭太, 曽山 武士, 曹 圭龍, 中村 昭伸, 阿保 大介, 工藤 與亮, 三好 秀明, 渥美 達也
  日本内分泌学会雑誌, 96, 2, 529, 529, (一社)日本内分泌学会, 2020年10月
  日本語
• 画像診断と病理 粘液線維肉腫
  原嶋 十考, 中川 純一, 原田 太以佑, 坂本 圭太, 工藤 與亮, 中里 信一, 清水 亜衣
  画像診断, 40, 12, 1158, 1159, (株)学研メディカル秀潤社, 2020年09月
  日本語
• 全身の関節周囲の多発腫瘤が診断の契機となった慢性結節性痛風の1例　　　　　　　　　　　　　　　
  小泉 富基, 坂本 圭太, 真鍋 徳子, 加藤 扶美, 工藤 與亮, 加藤 将
  Japanese Journal of Radiology, 38, Suppl., 8, 8, (公社)日本医学放射線学会, 2020年02月
  日本語
• AIDS患者に発症した肝EBV関連平滑筋腫の1例　　　　　　　　　　　　　　　
  金谷 本真, 坂本 圭太, 加藤 扶美, 真鍋 徳子, 工藤 興亮, 笠原 耕平, 荒 隆英, 高桑 恵美, 桑原 健
  Japanese Journal of Radiology, 38, Suppl., 8, 8, (公社)日本医学放射線学会, 2020年02月
  日本語
• Myofascia-dominant involvement on whole-body MRI as a risk factor for rapidly progressive interstitial lung disease in dermatomyositis.
  Karino K, Kono M, Kono M, Sakamoto K, Fujieda Y, Kato M, Amengual O, Oku K, Yasuda S, Atsumi T
  Rheumatology (Oxford, England), 59, 7, 1734, 1742, 2020年01月, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, OBJECTIVE: Rapidly progressive interstitial lung disease (RPILD) is a major cause of death in patients with DM. Although clinically amyopathic DM (CADM) represents risk for RPILD, the incidence rate of RPILD in patients with CADM varies widely. Whole-body (WB) MRI can reveal involvement of systemic muscle and myofascia. The objective of this study was to explore the risk factors for RPILD in patients with DM using WB-MRI. METHODS: This retrospective study comprised 41 patients with DM who underwent WB-MRI before the initiation of treatment in our hospital. Muscular and myofascial signals were scored on 42 muscular groups. The myofascia/muscle ratio was calculated and used to define the relevance of myofascia-dominant involvement. RPILD was defined as worsening of dyspnoea, hypoxaemia and radiographic ILD/fibrosis within 3 months from the onset of respiratory symptoms. RESULTS: Among the 41 patients, 17 had CADM and 30 had ILD, including 10 patients with RPILD. All patients including those with CADM showed abnormal signal intensity in both muscle and myofascia (median score: 15 and 23, respectively). Muscle signal scores positively correlated with the serum creatine kinase level (r = 0.714; P< 0.001). Patients with RPILD showed a significantly higher myofascia/muscle ratio than those without RPILD (1.929 vs 1.200; P= 0.027). Logistic regression analysis identified higher myofascia/muscle ratio as independent risk factors for developing RPILD. CONCLUSION: Myofascia-dominant involvement was defined and appreciated in patients with DM using WB-MRI. This may be one of the risk factors for RPILD.
• Heterogeneity of longitudinal and circumferential contraction in relation to late gadolinium enhancement in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction.
  Keita Sakamoto, Noriko Oyama-Manabe, Osamu Manabe, Tadao Aikawa, Yasuka Kikuchi, Harue Sasai-Masuko, Masanao Naya, Kohsuke Kudo, Fumi Kato, Nagara Tamaki, Hiroki Shirato
  Japanese journal of radiology, 36, 2, 103, 112, 2018年02月, ［査読有り］, ［国内誌］
  英語, 研究論文（学術雑誌）, PURPOSE: To evaluate heterogeneity of myocardial contraction in relation to extensive late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) patients with preserved left ventricular ejection fraction, using fast strain-encoded magnetic resonance imaging. MATERIALS AND METHODS: Twenty-two HCM patients and 24 age-matched control subjects were included in this retrospective study. The regional and global peak values of longitudinal and circumferential strain (LSregional, LSglobal, CSregional, CSglobal), and their regional heterogeneities were evaluated using coefficients of variation (LSCoV, CSCoV) in relation to LGE. Receiver operating characteristic curve analysis was performed to identify patients with a total left ventricular myocardial LGE ≥ 15%. RESULTS: LSglobal in HCM patients was significantly decreased compared to that in controls (- 14.4 ± 2.4% vs - 17.2 ± 2.0%; p = 0.0004), while CSglobal was not (p = 1.0). Negative LGE segments demonstrated decreased LSregional in HCM patients compared to in controls (p < 0.0001), while CSregional was not decreased. CSCoV demonstrated the largest area under the curve (AUC) (0.91), with high sensitivity (83%) and specificity (94%) for detection of HCM patients with extensive LGE, while the AUC of LSCoV was low (0.49). CONCLUSION: The heterogeneity in CSregional has a high diagnostic value for detection of HCM patients with extensive LGE.
• Relapsing Polychondritis With Increased Bone Marrow Signal on Magnetic Resonance Imaging in a 13-Year-Old Girl.
  Kanako Nakayama, Sayaka Yamamoto, Kimiaki Uetake, Masafumi Yamada, Yusuke Tozawa, Masahiro Ueki, Shunichiro Takezaki, Hiroki Nishimura, Yuji Nakamaru, Tomoko Mitsuhashi, Noriko Oyama-Manabe, Keita Sakamoto, Ryuta Arai, Tadashi Ariga
  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 24, 1, 52, 54, 2018年01月, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）
• Effectiveness of whole-body magnetic resonance imaging for the efficacy of biologic anti-rheumatic drugs in patients with rheumatoid arthritis: A retrospective pilot study
  Michihito Kono, Tamotsu Kamishima, Shinsuke Yasuda, Keita Sakamoto, Sawako Abe, Atsushi Noguchi, Toshiyuki Watanabe, Yuka Shimizu, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Tatsuya Atsumi
  MODERN RHEUMATOLOGY, 27, 6, 953, 960, 2017年, ［査読有り］
  英語, 研究論文（学術雑誌）
• CTが診断に有用であった繰り返す消化管出血症例　　　　　　　　　　　　　　　
  亀田 浩之, 真鍋 徳子, 菊池 穏香, 坂本 圭太, 三村 理恵, 加藤 扶美, 工藤 與亮, 藪崎 哲史, 宮本 憲幸, 西田 睦, 畑中 佳奈子, 大野 正芳, 高橋 典彦
  Japanese Journal of Radiology, 34, Suppl., 3, 3, (公社)日本医学放射線学会, 2016年02月
  日本語
• Observational cohort study of first-line bevacizumab with oxaliplatin or irinotecan and fluoropyrimidines in metastatic colorectal cancer: HGCSG0802-Analysis of early tumor shrinkage (ETS).
  Yuki Satoshi, Nakatsumi Hiroshi, Sawada Kentaro, Kato Takashi, Meguro Takashi, Nakamura Michio, Iwanaga Ichiro, Ehira Nobuyuki, Sonoda Norikazu, Kudo Mineo, Kato Kanji, Sogabe Susumu, Amano Toraji, Ono Kota, Sakamoto Keita, Miyamoto Noriyuki, Kudo Kohsuke, Sakamoto Naoya, Sakata Yuh, Komatsu Yoshito
  JOURNAL OF CLINICAL ONCOLOGY, 34, 4, 2016年02月01日, ［査読有り］
• Strategic Approach to the Splenic Artery in Laparoscopic Spleen-preserving Distal Pancreatectomy
  Kazuho Inoko, Yuma Ebihara, Keita Sakamoto, Noriyuki Miyamoto, Yo Kurashima, Eiji Tamoto, Toru Nakamura, Soichi Murakami, Takahiro Tsuchikawa, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano
  SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES, 25, 4, E122, E125, 2015年08月, ［査読有り］
  英語, 研究論文（学術雑誌）
• 発熱と骨病変が先行した小児白血病の1例　　　　　　　　　　　　　　　
  藪崎 哲史, 宮本 憲幸, 白土 博樹, 真鍋 徳子, 藤間 憲幸, 菊池 穏香, 坂本 圭太, 三村 理恵, 加藤 芙美, 工藤 與亮, 佐藤 智信, 長 祐子, 井口 晶裕
  Japanese Journal of Radiology, 33, Suppl., 2, 2, (公社)日本医学放射線学会, 2015年02月
  日本語
• Prediction of pancreatic anastomotic failure after pancreatic head resection using preoperative diffusion-weighted MR imaging
  Noriyuki Miyamoto, Satoshi Yabusaki, Keita Sakamoto, Yasuka Kikuchi, Rie Mimura, Fumi Kato, Noriko Oyama-Manabe, Bunya Takahashi, Takeshi Soyama, Daisuke Abo, Yusuke Sakuhara, Kohsuke Kudo, Hiroki Shirato, Toru Nakamura, Takahiro Tsuchikawa, Keisuke Okamura, Satoshi Hirano
  JAPANESE JOURNAL OF RADIOLOGY, 33, 2, 59, 66, 2015年02月, ［査読有り］
  英語, 研究論文（学術雑誌）
• Association of early tumor shrinkage with progression-free survival in patients with metastatic colorectal cancer treated with bevacizumab-based chemotherapy: HGCSG0802.
  Nakatsumi Hiroshi, Yuki Satoshi, Muranaka Tetsuhito, Fukushima Hiraku, Kato Takashi, Meguro Takashi, Nakamura Michio, Iwanaga Ichiro, Ehira Nobuyuki, Sonoda Norikazu, Kudo Mineo, Kato Kanji, Miyashita Kencho, Abe Masakazu, Miyamoto Noriyuki, Sakamoto Keita, Kudo Kohsuke, Sakamoto Naoya, Sakata Yuh, Komatsu Yoshito
  JOURNAL OF CLINICAL ONCOLOGY, 33, 3, 2015年01月20日, ［査読有り］
• 原因病変の多発が疑われた良性腫瘍性骨軟化症の1例 各種モダリティの中での超音波検査の役割　　　　　　　　　　　　　　　
  曽山 武士, 作原 祐介, 坂本 圭太, 高橋 文也, 阿保 大介, 工藤 與亮, 堀江 達則, 西田 睦
  超音波医学, 42, 1, 92, 92, (公社)日本超音波医学会, 2015年01月
  日本語
• Efficacy of Tocilizumab in Patients with Rheumatoid Arthritis: Sequential Evaluation Using Whole-Body Magnetic Resonance Imaging.
  Michihito Kono, Shinsuke Yasuda, Kazumasa Ohmura, Tomoko Fukui, Sanae Shimamura, Ikuma Nakagawa, Atsushi Noguchi, Haruki Shida, Toshiyuki Watanabe, Yuka Shimizu, Takashi Kurita, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Keita Sakamoto, Tamotsu Kamishima, Tatsuya Atsumi
  ARTHRITIS & RHEUMATOLOGY, 66, S518, S518, 2014年10月, ［査読有り］
  英語
• 腎腫瘤性病変における造影超音波検査による特徴的造影パターンの検討　　　　　　　　　　　　　　　
  堀江 達則, 西田 睦, 坂本 圭太, 作原 祐介, 佐藤 恵美, 井上 真美子, 工藤 悠輔, 表原 里実, 和田 妙子, 岩井 孝仁, 篠原 信雄, 野々村 克也
  超音波医学, 41, 1, 58, 59, (公社)日本超音波医学会, 2014年01月
  日本語