Feb. 2025, Biomedicines, Outstanding Reviewer Awards　　　　　　　　　　　　　　　
Biomedicines 2024 Outstanding Reviewer Award
Yasushige Shingu

Oct. 2021, 北海道大・部局横断シンポジウム実行委員会, 部局横断型若手研究助成事業 金賞　　　　　　　　　　　　　　　
冬眠動物と植物の低温耐性に学ぶ新たな心臓保存法の開発
新宮 康栄;山口 良文

Oct. 2020, 北海道大・部局横断シンポジウム実行委員会, Grants-in-Aid for Cross-department Young Researcher Grants of Hokkaido University　　　　　　　　　　　　　　　
冬眠動物の低温耐性に学ぶ心臓保存法の開発
新宮 康栄;山口 良文

2018, JATS, JATS Research Project Award　　　　　　　　　　　　　　　
カルニチンを用いた心臓弁膜症・肺癌・食道癌術後の心房細動予防
新宮 康栄

Feb. 2013, 日本心臓血管外科学会, 優秀演題　　　　　　　　　　　　　　　
新宮康栄

Effects of Left Ventricular Unloading on Cardiac Function, Heart Failure Markers, and Autophagy in Rat Hearts with Acute Myocardial Infarction
Ryota Azuma, Yasushige Shingu, Jingwen Gao, Satoru Wakasa
International Journal of Molecular Sciences, 06 May 2025
Scientific journal

A Protocol Investigation Comparing Transcatheter Repair with the Standard Surgical Procedure for Secondary Mitral Regurgitation
Francesco Nappi, Sanjeet Singh Avtaar Singh, Antonio Salsano, Aubin Nassif, Yasushige Shingu, Satoru Wakasa, Antonio Fiore, Cristiano Spadaccio, Zein EL-Dean
Journal of Clinical Medicine, 18 Dec. 2024
Scientific journal

Associations of sarcopenia and malnutrition with 30-day in-hospital morbidity and mortality after cardiac surgery.
Takahiro Abe, Tasuku Inao, Yasushige Shingu, Akira Yamada, Shingo Takada, Arata Fukushima, Noriko Oyama-Manabe, Isao Yokota, Satoru Wakasa, Shintaro Kinugawa, Takashi Yokota
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 17 Dec. 2024, [International Magazine]
English, Scientific journal, OBJECTIVES: Sarcopenia and malnutrition often occur simultaneously in adults with cardiovascular diseases. Our objective was to determine the associations of preoperative sarcopenia and malnutrition with major adverse cardiac and cerebral events (MACCE) after cardiac surgery. METHODS: We retrospectively analyzed 154 consecutive patients who underwent elective cardiac surgery between January 2015 and June 2018 at two institutions in Japan. Sarcopenia and nutritional status were preoperatively assessed by bilateral psoas muscle volume index (PMVI) using CT scans and the prognostic nutritional index (PNI), respectively. RESULTS: The median age in the total cohort was 69 years, and 43% were women. Within 30 days after surgery, 20 patients developed in-hospital MACCE and 7 patients died of any cause. Low PMVI (<72.25 cm3/m2) and low PNI (<48.15) were each independent predictors of postoperative MACCE occurrence with odds ratios (95% confidence interval) of 3.58 (1.22-10.53) and 3.73 (1.25-11.09) when adjusted for age and sex, and 3.25 (1.07-9.87) and 3.27 (1.08-9.89) when adjusted for preoperative left ventricular ejection fraction, angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker, and anticoagulant. In addition, the combination of low PMVI and low PNI conferred the highest risk of in-hospital MACCE among the 4 groups (ie, the low PMVI, low PNI, low PMVI+low PNI, and neither low PMVI nor low PNI groups). CONCLUSIONS: Preoperative low PMVI and low PNI were respectively associated with 30-day in-hospital MACCE occurrence after cardiac surgery. Notably, coexistence of these reductions further enhanced the risk of postoperative MACCE.

A study protocol for an international registry observational study evaluating clinical outcomes of transcatheter versus standard surgical mitral valve operation for secondary mitral regurgitation: the TEERMISO study
Francesco Nappi, Sanjeet Singh Avtaar Singh, Antonio Salsano, Cristiano Spadaccio, Yasushige Shingu, Satoru Wakasa, Antonio Fiore
02 Nov. 2024

L-Carnitine: A New Therapeutic Option for the Prevention of Atrial Fibrillation in Non-Cardiac Surgery—A Single-Group Interventional Pilot Study
Yasushige Shingu, Isao Yokota, Tatsuya Kato, Yasuhiro Hida, Kichizo Kaga, Jingwen Gao, Satoru Wakasa
Journal of Clinical Medicine, 18 Oct. 2024
Scientific journal

Orthotopic heart transplantation in patient with situs inversus and pectus excavatum: a case report.
Satoru Wakasa, Tomonori Ooka, Takuma Sato, Yasushige Shingu, Nobuyasu Kato, Toshiyuki Nagai, Toshihisa Anzai, Minoru Ono, Yoshiro Matsui
Surgical case reports, 10, 1, 202, 202, 30 Aug. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: Heart transplantation in patients with situs inversus is challenging, especially in terms of reconstruction of the systemic venous return. Several rerouting techniques have been presented but are associated with vulnerability to external compression, which might cause hemodynamic instability, especially in the presence of chest deformity. In this study, we report a rare case of successful heart transplantation in the presence of situs inversus and pectus excavatum. CASE PRESENTATION: A 55-year-old man, with a history of surgeries for corrected transposition of the great arteries with ventricular septal defect, was registered for heart transplantation owing to progression of heart failure. Subsequently, he had undergone a left ventricular assist device implantation; 14 years after registration, he underwent transplantation of the heart with normal anatomy. The inferior vena cava was reconstructed by anastomosing the left atria with a counterclockwise rotation of the donor heart and by lengthening the recipient inferior vena cava with a conduit made of the residual right atrial tissue. The superior vena cava was reconstructed using a donor innominate vein harvested with sufficient length. After successful weaning from cardiopulmonary bypass, the chest could not be closed because the heart was compressed owing to chest deformity, resulting in hemodynamic instability. Therefore, to exclude the left lung, a left pericardial screen was created using a bovine pericardium, allowing the chest to be closed with acceptable hemodynamics. The patient suffered postoperatively from a higher venous pressure, suggesting an obstruction of venous return early after surgery. The obstruction gradually resolved, and the patient was transferred for rehabilitation. CONCLUSIONS: Heart transplantation in the presence of situs inversus is challenging; moreover, the presence of pectus excavatum further complicates the procedure. The paradoxically larger left lung and chest deformity compressed and impaired reconstructed systemic venous return. Although intrathoracic exclusion of the left lung was effective, an intraoperative or early postoperative thoracoplasty for pectus excavatum was also a viable option. Patient-specific management is mandatory, depending on the anatomy.

Incidence of atrial fibrillation after esophageal cancer surgery with L-carnitine use: a preliminary single-group interventional study.
Yasushige Shingu, Isao Yokota, Toshiaki Shichinohe, Soichi Murakami, Yuma Ebihara, Yo Kurashima, Satoshi Hirano, Satoru Wakasa
Surgery today, 54, 8, 892, 898, Aug. 2024, [Domestic magazines]
English, Scientific journal, PURPOSE: We aimed to investigate the POAF rate and blood FABP4 levels after perioperative L-carnitine administration in patients with esophageal cancer. METHODS: L-carnitine (3 g in three divided doses) was administered to 15 patients 2 days before and 3 days after surgery. POAF during the study period and blood FABP4 levels (ELISA) before and after L-carnitine administration were evaluated. Accurate 95% confidence intervals (CI) for POAF incidence and changes in blood FABP4 levels were calculated. The preoperative predicted POAF rate was calculated using an application for esophageal cancer. The correlation between FABP4 levels and the predicted POAF rate was analyzed using Pearson's coefficient (r). RESULTS: Thirteen patients completed this study. The predicted POAF rate was 24% (17%, 34%) (median; interquartile range). The actual incidence of POAF was 7.7% (95% CI: 0.2-36%). Blood FABP4 levels changed from 10.3 to 7.0 ng/mL; the average change was - 3.3 (95% CI: - 6.6 to - 0.1). A positive correlation was found between preoperative FABP4 levels and the predicted POAF rates (r = 0.564). CONCLUSIONS: The POAF rate after esophageal surgery was 7.7% for L-carnitine. L-carnitine may reduce blood FABP4 levels. This preliminary study will contribute to the planning of sample sizes in future randomized trials.

Chronic Active Myocarditis After Transapical Transcatheter Aortic Valve Implantation.
Yuta Kobayashi, Toshiyuki Nagai, Kiwamu Kamiya, Satonori Tsuneta, Yasushige Shingu, Kento Wakabayashi, Kohsuke Kudo, Yoshihiro Matsuno, Satoru Wakasa, Toshihisa Anzai
Circulation journal : official journal of the Japanese Circulation Society, 88, 6, 1008, 1008, 24 May 2024, [International Magazine]
English, Scientific journal

Effects of Trehalose Preconditioning on H9C2 Cell Viability and Autophagy Activation in a Model of Donation after Circulatory Death for Heart Transplantation.
Jingwen Gao, Yasushige Shingu, Satoru Wakasa
Current issues in molecular biology, 46, 4, 3353, 3363, 12 Apr. 2024, [International Magazine]
English, Scientific journal, Donation after circulatory death (DCD) is a promising strategy for alleviating donor shortage in heart transplantation. Trehalose, an autophagy inducer, has been shown to be cardioprotective in an ischemia-reperfusion (IR) model; however, its role in IR injury in DCD remains unknown. In the present study, we evaluated the effects of trehalose on cardiomyocyte viability and autophagy activation in a DCD model. In the DCD model, cardiomyocytes (H9C2) were exposed to 1 h warm ischemia, 1 h cold ischemia, and 1 h reperfusion. Trehalose was administered before cold ischemia (preconditioning), during cold ischemia, or during reperfusion. Cell viability was measured using the Cell Counting Kit-8 after treatment with trehalose. Autophagy activation was evaluated by measuring autophagy flux using an autophagy inhibitor, chloroquine, and microtubule-associated protein 1A/1B light chain 3 B (LC3)-II by western blotting. Trehalose administered before the ischemic period (trehalose preconditioning) increased cell viability. The protective effects of trehalose preconditioning on cell viability were negated by chloroquine treatment. Furthermore, trehalose preconditioning increased autophagy flux. Trehalose preconditioning increased cardiomyocyte viability through the activation of autophagy in a DCD model, which could be a promising strategy for the prevention of cardiomyocyte damage in DCD transplantation.

Influence of epicardial adipose tissue inflammation and adipocyte size on postoperative atrial fibrillation in patients after cardiovascular surgery
Hiroyuki Natsui, Masaya Watanabe, Takashi Yokota, Satonori Tsuneta, Yoshizuki Fumoto, Haruka Handa, Matsushima Shouji, Jiro Koya, Kotaro Nishino, Daishiro Tatsuta, Takuya Koizumi, Takahide Kadosaka, Motoki Nakao, Taro Koya, Taro Temma, Yoichi M. Ito, Hatanaka C. Kanako, Yutaka Hatanaka, Shingu Yasushige, Satoru Wakasa, Shuhei Miura, Takahiko Masuda, Naritomo Nishioka, Shuichi Naraoka, Kayoko Ochi, Tomoko Kudo, Tsugumine Ishikawa, Toshihisa Anzai
Physiological Reports, 12, 6, e15957, Wiley, 28 Mar. 2024, [Peer-reviewed], [International Magazine]
English, Scientific journal, Abstract

Epicardial adipose tissue (EAT) is an active endocrine organ that is closely associated with occurrence of atrial fibrillation (AF). However, the role of EAT in the development of postoperative AF (POAF) remains unclear. We aimed to investigate the association between EAT profile and POAF occurrence in patients who underwent cardiovascular surgery. We obtained EAT samples from 53 patients to evaluate gene expression, histological changes, mitochondrial oxidative phosphorylation (OXPHOS) capacity in the EAT, and protein secretion in EAT‐conditioned medium. EAT volume was measured using computed tomography scan. Eighteen patients (34%) experienced POAF within 7 days after surgery. Although no significant difference was observed in EAT profile between patients with and without POAF, logistic regression analysis identified that the mRNA expression levels of tumor necrosis factor‐alpha (TNF‐α) were positively correlated and adipocyte size in the EAT was inversely correlated with onset of POAF, respectively. Mitochondrial OXPHOS capacity in the EAT was not associated with POAF occurrence; however, it showed an inverse correlation with adipocyte size and a positive correlation with adiponectin secretion. In conclusion, changes in the secretory profile and adipocyte morphology of the EAT, which represent qualitative aspects of the adipose tissue, were present before the onset of AF.

Interpapillary muscle distance independently predicts recurrent mitral regurgitation.
Ivancarmine Gambardella, Cristiano Spadaccio, Sanjeet S A Singh, Yasushige Shingu, Takashi Kunihara, Satoru Wakasa, Francesco Nappi
Journal of cardiothoracic surgery, 19, 1, 147, 147, 20 Mar. 2024, [International Magazine]
English, Scientific journal, OBJECTIVE: Ischaemic secondary mitral regurgitation (ISMR) after surgery is due to the displacement of papillary muscles resulting from progressive enlargement of the left ventricle end-diastolic diameter (LVEDD). Our aim was to prove that if the interpapillary muscle distance (IPMD) is surgically stabilized, an increase in LVEDD will not lead to a recurrence of ischaemic mitral regurgitation (MR). METHODS: Ninety-six patients with ISMR, who underwent surgical revascularisation and annuloplasty, were randomly assigned in a 1:1 ratio to undergo papillary muscle approximation (PMA). At the 5-year follow-up, we assessed the correlation between PMA and echocardiographic improvements, the effect size of PMA on echocardiographic improvements, and a prediction model for recurrent MR using inferential tree analysis. RESULTS: There was a significant correlation between PMA and enhancements in both the α and β angles (Spearman's rho > 0.7, p < 0.01). The α angle represents the angle between the annular plane and either the A2 annular-coaptation line or the P2 annular-coaptation line. The β angle indicates the angle between the annular plane and either the A2 annular-leaflet tip line or the P2 annular-leaflet tip line. PMA led to substantial improvements in LVEDD, tenting area, α and β angles, with a large effect size (Hedge's g ≥ 8, 95% CI ORs ≠ 1). The most reliable predictor of recurrent MR grade was the interpapillary distance, as only patients with an interpapillary distance greater than 40 mm developed ≥ 3 + grade MR. For patients with an IPMD of 40 mm or less, the best predictor of recurrent MR grade was LVEDD. Among the patients, only those with LVEDD greater than 62 mm showed moderate (2+) MR, while only those with LVEDD less than or equal to 62 mm had absent to mild (1+) MR. CONCLUSION: Prediction of recurrent ischaemic MR is not independent of progressive LVEDD increase. PMA-based surgical procedure stabilises IPMD.

Rough-zone suspension with mitral valve replacement for ventricular functional mitral regurgitation.
Satoru Wakasa, Yasushige Shingu
General thoracic and cardiovascular surgery, 72, 4, 247, 249, 02 Nov. 2023, [Domestic magazines]
English, Scientific journal, Chordal preservation is recommended in mitral valve replacement for functional mitral regurgitation to preserve left ventricular function. In contrast, papillary muscle suspension toward the anterior mitral annulus can induce left ventricular reverse remodeling after mitral valve replacement for functional mitral regurgitation. However, the extent of suspension depends on the surgeon's experience. Therefore, we developed a new concept of chordal preservation, called rough-zone suspension, which not only spares the subvalvular structure but also suspends the papillary muscles toward the annulus. This procedure is simple and reproducible for determining the extent of suspension, and can increase the probability of left ventricular reverse remodeling after mitral valve replacement for functional mitral regurgitation.

Impact of sarcopenia on early and mid-term outcomes of surgery for acute type A aortic dissection in octogenarians.
Takahiro Ishigaki, Satoru Wakasa, Yasushige Shingu, Yohei Ohkawa, Akira Yamada
General thoracic and cardiovascular surgery, 71, 11, 674, 680, Nov. 2023, [Domestic magazines]
English, Scientific journal, OBJECTIVE: To determine the association between sarcopenia and surgical outcomes in octogenarians with acute type A aortic dissection. METHODS: We enrolled 72 octogenarians who had undergone type A aortic dissection surgery between April 2013 and March 2019. The psoas muscle index, an indexed area of the psoas muscle at the L3 level on preoperative computed tomography, was obtained as an indicator of sarcopenia. The study participants were divided into sarcopenia and non-sarcopenia groups based on the mean psoas muscle index. The postoperative outcomes were compared between the groups. RESULTS: The median age was 84 years (interquartile range 82-87 years), and 13 patients were male. The mean psoas muscle index was 3.53 ± 0.97 cm2/m2. Except for sex, no significant differences were observed in patients' baseline characteristics and operative data between the two groups. The 30-day mortality rates in the sarcopenia and non-sarcopenia groups were 14% and 8%, respectively (P = 0.71), and postoperative morbidity was similar in both groups. Postoperative all-cause mortality was significantly higher in the sarcopenia group (log-rank P = 0.038), especially in patients aged 85 years or older (log-rank P < 0.01). The sarcopenia group had a lower home discharge rate than the non-sarcopenia group (21% vs. 54%, P < 0.01), and home discharge was associated with longer survival (log-rank P = 0.015). CONCLUSIONS: All-cause mortality after emergency surgery for acute type A aortic dissection was significantly higher in octogenarians with sarcopenia than in those without, especially in patients aged 85 years or older.

Differences in blood flow dynamics between balloon- and self-expandable valves in patients with aortic stenosis undergoing transcatheter aortic valve replacement.
Yuki Takahashi, Kiwamu Kamiya, Toshiyuki Nagai, Satonori Tsuneta, Noriko Oyama-Manabe, Takeshi Hamaya, Sho Kazui, Yutaro Yasui, Kohei Saiin, Seiichiro Naito, Yoshifumi Mizuguchi, Sakae Takenaka, Atsushi Tada, Suguru Ishizaka, Yuta Kobayashi, Kazunori Omote, Takuma Sato, Yasushige Shingu, Kohsuke Kudo, Satoru Wakasa, Toshihisa Anzai
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 25, 1, 60, 60, 26 Oct. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: The differences in pre- and early post-procedural blood flow dynamics between the two major types of bioprosthetic valves, the balloon-expandable valve (BEV) and self-expandable valve (SEV), in patients with aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR), have not been investigated. We aimed to investigate the differences in blood flow dynamics between the BEV and SEV using four-dimensional flow cardiovascular magnetic resonance (4D flow CMR). METHODS: We prospectively examined 98 consecutive patients with severe AS who underwent TAVR between May 2018 and November 2021 (58 BEV and 40 SEV) after excluding those without CMR because of a contraindication, inadequate imaging from the analyses, or patients' refusal. CMR was performed in all participants before (median interval, 22 [interquartile range (IQR) 4-39] days) and after (median interval, 6 [IQR 3-6] days) TAVR. We compared the changes in blood flow patterns, wall shear stress (WSS), and energy loss (EL) in the ascending aorta (AAo) between the BEV and SEV using 4D flow CMR. RESULTS: The absolute reductions in helical flow and flow eccentricity were significantly higher in the SEV group compared in the BEV group after TAVR (BEV: - 0.22 ± 0.86 vs. SEV: - 0.85 ± 0.80, P < 0.001 and BEV: - 0.11 ± 0.79 vs. SEV: - 0.50 ± 0.88, P = 0.037, respectively); there were no significant differences in vortical flow between the groups. The absolute reduction of average WSS was significantly higher in the SEV group compared to the BEV group after TAVR (BEV: - 0.6 [- 2.1 to 0.5] Pa vs. SEV: - 1.8 [- 3.5 to - 0.8] Pa, P = 0.006). The systolic EL in the AAo significantly decreased after TAVR in both the groups, while the absolute reduction was comparable between the groups. CONCLUSIONS: Helical flow, flow eccentricity, and average WSS in the AAo were significantly decreased after SEV implantation compared to BEV implantation, providing functional insights for valve selection in patients with AS undergoing TAVR. Our findings offer valuable insights into blood flow dynamics, aiding in the selection of valves for patients with AS undergoing TAVR. Further larger-scale studies are warranted to confirm the prognostic significance of hemodynamic changes in these patients.

Blood flow characteristics of the bilateral internal thoracic artery: implications of optimal graft configuration for coronary artery bypass grafting to maximize blood supply.
Takashi Kunihara, Yasushige Shingu, Satoru Wakasa, Hiroshi Sugiki, Yasuhiro Kamikubo, Norihiko Shiiya, Yoshiro Matsui
General thoracic and cardiovascular surgery, 71, 10, 552, 560, Oct. 2023, [Domestic magazines]
English, Scientific journal, PURPOSE: There is controversy regarding which internal thoracic artery (ITA) should be anastomosed to the left anterior descending artery (LAD). Here, we propose an optimal graft design based on measurement of blood flow in the ITA. METHODS: Sixty-one patients (53 men, median age 68 [62-75] years) undergoing first elective coronary artery bypass grafting were enrolled. Fifty-seven left ITAs (LITAs) and 28 right ITAs (RITAs) were harvested in either a semi-skeletonized manner using a harmonic scalpel covered with papaverine-soaked gauze (group-A, n = 45) or a fully skeletonized manner using electrocautery with intraluminal papaverine injection (group-B, n = 41). Free flow of 33 ITAs was measured after pharmacological dilatation and in situ ITA-LAD flow was measured in 59 patients by transit-time flowmetry. RESULTS: RITA and LITA free flow were 147.0 [87.8-213.0] mL/min and 108.0 [90.0-144.0] mL/min, respectively (P = 0.199). The group-B had significantly higher ITA free flow (135.0 [102.0-171.0] mL/min) than group-A (63.0 [36.0-96.0] mL/min, P = 0.009). In 13 patients with bilateral ITA harvesting, free flow of the RITA (138.0 [79.5-204.0] mL/min) was also significantly higher than the LITA (102.0 [81.0-138.0] mL/min, P = 0.046). There was no significant difference between RITA and LITA flow anastomosed to the LAD. The group-B had significantly higher ITA-LAD flow (56.5 [32.3-73.6] mL/min) than group-A (40.9 [20.1-53.7] mL/min, P = 0.023). CONCLUSION: RITA provides significantly higher free flow than LITA but similar blood flow to the LAD. Full skeletonization with intraluminal papaverine injection maximizes both free flow and ITA-LAD flow.

Surgical repair of a residual lesion of mixed-type total anomalous pulmonary venous connection using a vertical vein as a free graft: a case report(タイトル和訳中)　　　　　　　　　　　　　　　
Watabe Yoshinobu, Kato Nobuyasu, Niwano Haruki, Shingu Yasushige, Ooka Tomonori, Kato Hiroki, Abe Shinji, Wakasa Satoru
General Thoracic and Cardiovascular Surgery Cases, 2, 1 of 5, 5 of 5, BioMed Central, Aug. 2023
English

当科における冠動脈に対する外科介入　　　　　　　　　　　　　　　
加藤 伸康, 阿部 慎司, 新宮 康栄, 大岡 智学, 加藤 裕貴, 山澤 弘州, 武田 充人, 若狭 哲
日本小児循環器学会総会・学術集会抄録集, 59回, [II, 03], (NPO)日本小児循環器学会, Jul. 2023
Japanese

Impact of Steroid on Macrophage Migration Inhibitory Factor During and After Cardiopulmonary Bypass.
Takashi Kunihara, Yasushige Shingu, Satoru Wakasa, Norihiko Shiiya, Satoshi Gando
ASAIO journal (American Society for Artificial Internal Organs : 1992), 69, 4, 391, 395, 01 Apr. 2023, [International Magazine]
English, Scientific journal, Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine released in response to glucocorticoids, which counter-regulates the effects of glucocorticoids. This study was performed to determine the impact of steroids on the expression of MIF and other pro- and anti-inflammatory cytokines during and after cardiopulmonary bypass (CPB). Twenty adult patients (10 men, 64 ± 8 years old) who underwent elective cardiac surgery by CPB were given either 2000 mg (group-H, n = 10) or 500 mg of methylprednisolone (group-L, n = 10) during CPB. The serum concentrations of MIF, interleukin (IL)-1β, IL-8, IL-10, and tumor necrosis factor-alpha (TNF-α) were measured at eight time points until 36 hours after skin closure. The early postoperative course was uneventful for all patients. There were no significant differences in duration of operation, CPB, or aortic cross-clamping (AXC) between the two groups. MIF and IL-10 levels peaked just after the conclusion of CPB and decreased gradually thereafter. IL-1β, IL-8, and TNF-α were undetectable throughout the study period. There were no significant differences in MIF or IL-10 levels between the two groups. Peak levels of MIF in all patients were significantly correlated with the duration of CPB and AXC, whereas no such correlation was observed for IL-10. MIF or IL-10 levels were significantly elevated during and after CPB, but there were no differences between the two doses of steroid administration. Both steroid doses sufficiently suppressed proinflammatory cytokines. MIF better reflected the invasiveness of the operation than IL-10.

A preliminary prediction model using a deep learning software program for prolonged hospitalization after cardiovascular surgery.
Ryota Murase, Yasushige Shingu, Satoru Wakasa
Surgery today, 53, 3, 393, 395, 05 Aug. 2022, [Domestic magazines]
English, Scientific journal, A prolonged length of hospital stay (LOS) has become an important issue among patients undergoing cardiovascular surgery in our aging society. However, there are no established prediction models for a prolonged LOS. We therefore created a prediction model of a prolonged LOS using a deep learning software program (Prediction One; Sony Network Communications Inc., Tokyo, Japan) using preoperative data. Subjects were 157 patients (121 for training data, 36 for validation data). A prolonged LOS was defined as a more than 30-day postoperative stay due to physical inactivity. The area under the receiver operating characteristic curve and the accuracy of the model in the validation data were 0.806 and 67%, respectively. In conclusion, the preliminary model demonstrated acceptable performance for the prediction of a prolonged LOS after cardiovascular surgery.

Cardioprotective effects of chloroquine pretreatment on ischemic and reperfusion injury via activation of ERK1/2 in isolated rat hearts.
Ryota Murase, Yasushige Shingu, Satoru Wakasa
Molecular biology reports, 49, 10, 9429, 9436, 27 Jul. 2022, [International Magazine]
English, Scientific journal, PURPOSE: Several therapeutic agents have been found to prevent myocardial ischemic and reperfusion (I/R) injury after cardiac surgery; however, no drug is routinely used to afford cardioprotective benefits in clinical settings. Herein, we aimed to determine whether chloroquine (CQ) pretreatment attenuates I/R injury after global ischemia in isolated rat hearts and elucidate mechanisms underlying the effects of CQ. METHODS: Isolated rat hearts were subjected to 30-min global ischemia, followed by 60-min reperfusion with Krebs-Henseleit buffer (KHB). Immediately before ischemia, 10 mL of pretreatment solutions (KHB, n = 4 or KHB + CQ [100 μM], n = 4) were injected through the aortic root. Cardiac function was examined based on the rate pressure product (RPP). Myocardial apoptosis was evaluated using TUNEL staining. To assess the reperfusion ischemia salvage kinase pathway, protein expression levels of AKT and extracellular signal-regulated kinase (ERK1/2) were determined using western blotting. To investigate the role of ERK1/2, an ERK1/2 selective inhibitor was used in eight additional rats. RESULTS: The recovery rate of the RPP was higher in the KHB + CQ group than in the KHB group 60 min after I/R (KHB, 44 ± 3% vs. KHB + CQ, 69 ± 7%; P = 0.019, d = 2.2). CQ pretreatment reduced apoptosis and enhanced the phosphorylation of ERK1/2; however, AKT phosphorylation was unaltered. In addition, the ERK1/2 inhibitor abolished CQ-mediated cardioprotective effects. CONCLUSIONS: CQ pretreatment showed protective effects on cardiac function after I/R by activating ERK1/2.

当院の体肺動脈短絡手術の治療成績　　　　　　　　　　　　　　　
加藤 伸康, 阿部 慎司, 新宮 康栄, 加藤 裕貴, 大岡 智学, 泉 岳, 山澤 弘州, 武田 充人, 若狭 哲
日本小児循環器学会総会・学術集会抄録集, 58回, [III, 04], (NPO)日本小児循環器学会, Jul. 2022
Japanese

植込型補助人工心臓治療におけるunmet medical needsの考察　　　　　　　　　　　　　　　
渡部 克将, 大岡 智学, 松本 嶺, 東 亮太, 須野 賢一郎, 稗田 哲也, 石垣 隆弘, 村瀬 亮太, 阿部 慎司, 加藤 伸康, 加藤 裕貴, 新宮 康栄, 若狭 哲
北海道外科雑誌, 67, 1, 92, 92, 北海道外科学会, Jun. 2022
Japanese

Protective effects of trehalose preconditioning on cardiac and coronary endothelial function through eNOS signaling pathway in a rat model of ischemia-reperfusion injury.
Kenichiro Suno, Yasushige Shingu, Satoru Wakasa
Molecular and cellular biochemistry, 477, 10, 2403, 2414, 17 May 2022, [International Magazine]
English, Scientific journal, Coronary endothelial dysfunction is a major cause of ischemia-reperfusion (I/R) injury. Trehalose, a natural disaccharide, has been reported to ameliorate endothelial dysfunction during aging by activating endothelial nitric oxide synthase (eNOS); however, its role in I/R injury is unknown. This study evaluated the effects of trehalose preconditioning on cardiac and coronary endothelial function after I/R. Langendorff-perfused rat hearts underwent 30 min of global ischemia followed by 80 min of reperfusion with or without trehalose preconditioning. Rate pressure product (RPP) and coronary flow (CF) were measured during reperfusion. Perivascular edema was assessed by hematoxylin and eosin staining. Myocardial oxidative stress and apoptosis were evaluated by immunohistochemistry and TUNEL staining, respectively. eNOS dimerization was determined by western blotting. An eNOS inhibitor was used to examine the role of eNOS. Trehalose preconditioning showed a higher recovery rate after I/R as indicated by high RPP (control vs. trehalose, 28 ± 6% vs. 46 ± 9%; P = 0.017, Cohen's d = 2.3) and CF values (35 ± 10% vs. 55 ± 9%; P = 0.025, d = 1.7). Furthermore, trehalose preconditioning reduced perivascular edema, myocardial oxidative stress, and apoptosis. The eNOS dimerization ratio was increased by trehalose (1.2 ± 0.2 vs. 1.6 ± 0.2; P = 0.023, d = 2.1), which was associated with the recovery of RPP and CF. These effects of trehalose were abolished by the eNOS inhibitor. Trehalose preconditioning showed protective effects on cardiac and coronary endothelial function after I/R through the eNOS signaling pathway.

Changes in AMPKα and Ubiquitin Ligases in Myocyte Reverse Remodeling after Surgical Ventricular Reconstruction in rats with ischemic cardiomyopathy.
Yasushige Shingu, Tetsuya Hieda, Satoshi Sugimoto, Hidetsugu Asai, Tomoji Yamakawa, Satoru Wakasa
Molecular biology reports, 49, 6, 4885, 4892, 08 May 2022, [International Magazine]
English, Scientific journal, BACKGROUND: The change in myocardial protein degradation systems after ventricular unloading has been unknown. We aimed to evaluate the anti-hypertrophic protein adenosine monophosphate-activated protein kinase (AMPK) and two major protein degradation systems (ubiquitin proteasome system and autophagy) in a model of surgical ventricular reconstruction (SVR) in rats with ischemic cardiomyopathy. METHODS AND RESULTS: Rats were randomized into the following groups: sham/sham (control group), myocardial infarction (MI)/sham (sham group) and MI/SVR (SVR group), with an interval of 4 weeks. Two (early, n = 5 for each) and 28 days (late, n = 5 for each) after SVR, ventricular size, and wall stress were assessed. Myocyte area, protein expression of AMPKα and autophagy markers, and gene expression of ubiquitin ligases (Atrogin-1 and Murf-1) were evaluated in the late phase. In the early phase, left ventricular dimensions and wall stress were smaller in the SVR group than in the sham group, whereas they were comparable in the late period. Myocyte area in the SVR group was reduced to the value in the control group, while it was larger in the sham group than in the control group. Total-AMPKα, p-AMPKα, and AMPKα phosphorylation rates were higher, and Atrogin-1 and Murf-1 were lower in the SVR group than in the sham group, while the autophagy markers were not different between the groups. p-AMPKα had strong negative correlations with myocyte area, Atrogin-1, and Murf-1. CONCLUSIONS: In myocyte reverse remodeling after SVR, AMPKα phosphorylation increased in association with reduced gene expression of ubiquitin ligases.

Bronchial artery hypertrophy-associated perioperative pulmonary hemorrhage in cardiovascular surgery: a case report.
Shinji Abe, Yasuhiro Kamikubo, Nobuyasu Kato, Hiroki Kato, Tomonori Ooka, Yasushige Shingu, Satoru Wakasa
Surgical case reports, 8, 1, 80, 80, 29 Apr. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: Pulmonary hemorrhage is a life-threatening complication of cardiovascular surgery. Bronchial artery hypertrophy, a rare pathology associated with inflammatory and ischemic respiratory diseases, increases the risk of pulmonary hemorrhage; however, its involvement in cardiovascular surgery is not well known. We present two cardiovascular surgical cases in which embolization of the hypertrophied bronchial artery was effective in controlling perioperative pulmonary hemorrhage. CASE PRESENTATION: The first case was a 51-year-old man with chronic obstructive pulmonary disease who developed acute type A aortic dissection. After emergent surgery, his blood pressure suddenly dropped in the intensive care unit; computed tomography revealed a right hemothorax. Because a 4-mm dilated bronchial artery was identified on preoperative computed tomography, the hemothorax was suspected to be associated with bronchial artery hypertrophy. Selective bronchial arteriography was emergently performed and revealed a right pulmonary parenchymal blush. After subsequent coil embolization of the bronchial artery, the parenchymal blush disappeared, and his hemodynamic condition stabilized. The second case was a 66-year-old man with bronchiectasis who was referred for redo aortic valve replacement due to structural valve deterioration. A bioprosthesis was previously implanted to avoid permanent anticoagulation because the patient had repeated episodes of hemoptysis; however, he still had persistent hemosputum during admission for the redo aortic valve replacement. A dilated bronchial artery 3.7 mm in size was incidentally identified on preoperative computed tomography, and hence, the repeated hemosputum was suspected to be associated with bronchial artery hypertrophy. Bronchial arteriography revealed a right pulmonary parenchymal blush, and prophylactic embolization of the bronchial artery was performed. The hemosputum disappeared after the procedure, and redo aortic valve replacement was performed uneventfully 8 days later. CONCLUSION: In cardiovascular surgery, the risk of pulmonary hemorrhage associated with bronchial artery hypertrophy should be considered, especially in patients with inflammatory and ischemic respiratory diseases.

Reduction of tethering distance by papillary muscle tugging approximation with mitral valve replacement for non-ischemic functional mitral regurgitation induces left ventricular reverse remodeling.
Takahiro Ishigaki, Satoru Wakasa, Yasushige Shingu, Yohei Ohkawa, Akira Yamada, Toshihisa Anzai, Yoshiro Matsui
Journal of cardiology, 79, 4, 530, 536, Apr. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: Functional mitral regurgitation (FMR) is caused by left ventricular (LV) remodeling and subsequent tethering of the mitral valve (MV). If LV remodeling is irreversibly advanced, it could not be attenuated by the MV procedure alone, although the additional subvalvular procedure could induce LV reverse remodeling by forcibly reducing MV tethering. This study aimed to assess the anti-tethering effect of papillary muscle tugging approximation (PMTA) on LV reverse remodeling after mitral valve replacement (MVR) for non-ischemic FMR. METHODS: The study subjects were 19 patients who underwent MVR with and without PMTA [MVR + PMTA (n = 11) and MVR alone (n = 8), respectively] for non-ischemic FMR. The tethering distance (TD) and LV end-systolic volume (ESV) at the preoperative, postoperative, and follow-up periods were assessed in terms of their correlation and time-dependent changes. The intra-LV energy efficiency was also evaluated through vector flow mapping analysis. RESULTS: TD and ESV were comparable between both procedures preoperatively and did not change after MVR alone. In MVR + PMTA, however, a significant decrease was identified in TD and ESV at the early postoperative and follow-up periods, respectively [TD = 48, 30, and 31 mm (p < 0.001) and ESV = 159, 133, and 82 mL (p < 0.001) at the preoperative, postoperative, and follow-up periods, respectively]. Finally, at follow-up, the extent of change from the preoperative value in ESV significantly correlated with that in TD (ρ = 0.81, p < 0.001 for overall; ρ = 0.93, p < 0.001 for MVR + PMTA; ρ = 0.86, p = 0.011 for MVR alone). The ratio of TD to ESV was also significantly correlated with systolic energy loss to LV stroke work after MVR + PMTA (ρ = 0.81, p = 0.015). CONCLUSIONS: PMTA for non-ischemic FMR could induce LV reverse remodeling depending on the extent of postoperative TD reduction. A smaller TD to ESV was associated with a higher intra-LV energy efficiency after PMTA + MVR.

人工知能を用いた心大血管手術後長期リハビリ症例予測モデルの構築と検証　　　　　　　　　　　　　　　
村瀬 亮太, 新宮 康栄, 加藤 伸康, 加藤 裕貴, 大岡 智学, 若狭 哲
日本臨床外科学会雑誌, 83, 3, 600, 600, 日本臨床外科学会, Mar. 2022
Japanese

Effects of trehalose on recurrence of remodeling after ventricular reconstruction in rats with ischemic cardiomyopathy.
Tetsuya Hieda, Yasushige Shingu, Satoshi Sugimoto, Hidetsugu Asai, Tomoji Yamakawa, Satoru Wakasa
Heart and vessels, 37, 3, 528, 537, Mar. 2022, [Domestic magazines]
English, Scientific journal, Recurrence of left ventricular (LV) remodeling after surgical ventricular reconstruction (SVR) for ischemic cardiomyopathy has been reported to be partially attributed to autophagy. We aimed to examine the effects of trehalose, an autophagy inducer, on the recurrence of LV remodeling after SVR. After SVR in rats with ICM, trehalose was orally administered. The changes in LV end-diastolic dimension (LVEDD) and fractional shortening (FS) were evaluated. The activation of myocardial autophagy was also estimated by autophagy markers: microtubule-associated light chain 3 II (LC3-II) and p62; the former usually increases and the latter decreases if autophagy is activated. Significant LV reverse remodeling was observed early after SVR. On the other hand, the 28th postoperative day SVR + trehalose was associated with smaller LVEDD and better FS than SVR alone (LVEDD, P = 0.043; FS, P < 0.01). LC3-II increased comparably in both groups, while p62 was significantly lower in the SVR + trehalose group than in the SVR alone group (P < 0.01). In conclusion, trehalose attenuated the recurrence of LV remodeling and changed autophagy markers after SVR in rats with ICM. Trehalose may be a candidate for adjuvant therapy to retain the effects of SVR.

幼少期に留置した肺動脈ステント内狭窄に対する外科治療の経験　　　　　　　　　　　　　　　
加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲
日本成人先天性心疾患学会雑誌, 11, 1, 195, 195, 日本成人先天性心疾患学会, Jan. 2022
Japanese

Iatrogenic Arteriovenous Fistula of Subclavian Artery to Vertebral Vein with Perimedullary Vein Reflux
Sato Koji, Shingu Yasushige, Fusegawa Masato, Ishigaki Takahiro, Wakasa Satoru
Annals of Vascular Diseases, advpub, 3, 193, 196, The Editorial Committee of Annals of Vascular Diseases, 2022, [Domestic magazines]
English, Scientific journal, Iatrogenic arteriovenous fistula (AVF) rarely develops around the proximal subclavian artery, although open surgical repair of this etiology is known to be complicated as deep dissection is required around the fistula surrounded by dilated veins. In this study, we present the case of a 64-year-old man, who was referred to our hospital, with AVF between the right subclavian artery and the right vertebral vein. He had a history of accidental puncture of the right subclavian artery. An endovascular repair using a covered stent was successfully performed, and the AVF disappeared. Thus, covered stent placement should be considered as the first-line treatment for a deeply developed AVF, if anatomically feasible.

Simple Chordal Replacement with a Newly Designed "Mitral Plate" in Mitral Valvuloplasty.
Yoshiro Matsui, Suguru Kubota, Tatsuya Seki, Yasushige Shingu, Satoru Wakasa
The Annals of thoracic surgery, 114, 2, e141-e144, 09 Dec. 2021, [International Magazine]
English, Scientific journal, Mitral valvuloplasty using Gore-Tex as the artificial chordae is often associated with difficulties in determining the length of the artificial chordae, achieving the correct artificial chordae length, and preventing knot slippage, especially for beginners. We describe a simple technique involving a novel device called the "Mitral Plate," which enables surgeons to automatically determine the correct length of the artificial chordae and tie slippery knots without performing excessive saline tests.

L-Carnitine supplementation for the prevention of postoperative atrial fibrillation in aortic valve surgery.
Yasushige Shingu, Nobuyasu Katoh, Tomonori Ooka, Hiroki Katoh, Satoru Wakasa
General thoracic and cardiovascular surgery, 69, 11, 1460, 1466, Nov. 2021, [Domestic magazines]
English, Scientific journal, OBJECTIVES: L-Carnitine, a quaternary amine, improves fatty acid metabolism in the heart and has anti-inflammatory effects. Several studies have reported the efficacy of L-carnitine for the prophylaxis of arrhythmia. We assessed the clinical effectiveness of L-carnitine in preventing postoperative atrial fibrillation (POAF) in aortic valve surgery. METHODS: Thirty patients who underwent aortic valve surgery were included. Fifteen patients had no prophylaxis other than conventional measures (control), while 15 patients received oral L-carnitine for 9 days (daily dose of 3 g). The incidence of POAF during 1 week after surgery was compared between the two groups. The multivariable logistic regression analysis for POAF was performed using the pre- and intraoperative parameters. RESULTS: Preoperative characteristics and operative data were comparable between the groups. The POAF rate was significantly lower in the L-carnitine group than in the control (20% and 60%, respectively; P = 0.025). L-Carnitine use was an independently negative predictor for POAF (odds ratio 0.067; 95% confidence interval 0.006-0.768). CONCLUSIONS: L-Carnitine administration may have potential for the prevention of POAF in aortic valve surgery.

低左心機能を伴う虚血性閉鎖不全症〜外科手術vs Mitraclip〜 虚血性僧帽弁閉鎖不全症に対する外科治療戦略　　　　　　　　　　　　　　　
若狭 哲, 新宮 康栄, 加藤 伸康, 阿部 慎司, 大岡 智学, 松居 喜郎
日本胸部外科学会定期学術集会, 74回, CWS2, 3, (一社)日本胸部外科学会, Oct. 2021
Japanese

混合型TAPVC術後の遺残病変修復に際して垂直静脈を遊離グラフトとして用いた1例　　　　　　　　　　　　　　　
渡部 克将, 加藤 伸康, 庭野 陽樹, 松本 嶺, 東 亮太, 須野 賢一郎, 石垣 隆弘, 稗田 哲也, 村瀬 亮太, 阿部 慎司, 新宮 康栄, 大岡 智学, 若狭 哲
日本胸部外科学会定期学術集会, 74回, CCPA3, 8, (一社)日本胸部外科学会, Oct. 2021
Japanese

クロロキンの心筋虚血再灌流障害抑制効果の実験的検討　　　　　　　　　　　　　　　
村瀬 亮太, 新宮 康栄, 加藤 伸康, 加藤 裕貴, 大岡 智学, 若狭 哲
日本胸部外科学会定期学術集会, 74回, COP35, 4, (一社)日本胸部外科学会, Oct. 2021
Japanese

非虚血性機能性僧帽弁閉鎖不全症に対する僧帽弁置換術において僧帽弁下手技によるアンチテザリング効果の追加が術後左室リバースリモデリングを誘導する　　　　　　　　　　　　　　　
石垣 隆弘, 若狭 哲, 新宮 康栄, 大川 洋平, 山田 陽, 松居 喜郎
日本胸部外科学会定期学術集会, 74回, COP41, 4, (一社)日本胸部外科学会, Oct. 2021
Japanese

ECMO運用に関わる院内ガイドラインの作成　　　　　　　　　　　　　　　
藤原 晶, 若狭 哲, 大岡 智学, 斉藤 仁志, 新宮 康栄, 加賀 基知三, 太田 稔, 南須原 康行
日本胸部外科学会定期学術集会, 74回, OD1, 1, (一社)日本胸部外科学会, Oct. 2021
Japanese

ファロー四徴症に対するValve slicingを用いた肺動脈弁温存の検討　　　　　　　　　　　　　　　
稗田 哲也, 加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲
日本胸部外科学会定期学術集会, 74回, COD38, 3, (一社)日本胸部外科学会, Oct. 2021
Japanese

Apex rotation as a risk factor for total anomalous pulmonary connection repair in single ventricle.
Hidetsugu Asai, Yasushige Shingu, Jin Ikarashi, Yuchen Cao, Daisuke Takeyoshi, Yosuke Arai, Noriyoshi Ebuoka, Tsuyoshi Tachibana
Journal of cardiac surgery, 36, 9, 3078, 3084, Sep. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: The high incidence of postoperative pulmonary venous obstruction (PVO) is a major mortality-associated concern in patients with right atrial isomerism and extracardiac total anomalous pulmonary venous connection (TAPVC). We evaluated new anatomical risk factors for reducing the space behind the heart after TAPVC repair. METHODS: Eighteen patients who underwent TAPVC repair between 2014 and 2020 were enrolled. Sutureless technique was used in 12 patients and conventional repair in six patients. The angle between the line perpendicular to the vertebral body and that from the vertebral body to the apex was defined as the "vertebral-apex angle (V-A angle)." The ratio of postoperative and preoperative angles, indicating the apex's lateral rotation, was compared between patients with and without PVO. RESULTS: The median (interquartile range) age and body weight at repair were 102 (79-176) days and 3.8 (2.6-4.8) kg, respectively. The 1-year survival rate was 83% (median follow-up, 29 [11-36] months). PVO occurred in seven patients (39%), who showed an obstruction of one or two branches in the apex side. The postoperative V-A angle (46° [45°-50°] vs. 36° [29°-38°], p = 0.001) and the ratio of postoperative and preoperative V-A angles (1.27 [1.24-1.42] vs. 1.03 [0.98-1.07], p = 0.001) were significantly higher in the PVO group than in the non-PVO group. The cut-off values of the postoperative V-A angle and ratio were 41° and 1.17, respectively. CONCLUSION: A postoperative rotation of the heart apex into the ipsilateral thorax was a risk factor for branch PVO after TAPVC repair.

Intra-Atrial Rerouting of Anomalous Systemic Venous Connection and Septation of Common Atrium in Intracardiac Repair of Complete Atrioventricular Septal Defect with Left Isomerism and Dextrocardia: A Case Report
Kato Nobuyasu, Takeda Atsuhito, Arai Yosuke, Hatta Eiichiro, Yakuwa Satoshi, Shingu Yasushige, Ooka Tomonori, Wakasa Satoru
Pediatric Cardiology and Cardiac Surgery, 37, 2, 126, 132, Japanese Society of Pediatric Cardiology and Cardiac Surgery, 01 Aug. 2021
Japanese, Left isomerism is frequently associated with anomalous systemic venous connection and common atrium, requiring systemic venous abnormality correction and common-atrium septation in biventricular repair. Our case was a 4-year-old girl diagnosed with left isomerism, dextrocardia, complete atrioventricular septal defect, common atrium, bilateral superior vena cava, and interruption of the inferior vena cava with hemiazygos vein connection. She underwent intracardiac repair with intra-atrial rerouting. Preoperative computed tomography suggested that extracardiac reconstruction of the anomalous systemic vein was inappropriate, and showed that all the pulmonary veins drain to the common chamber in the common atrium. Thus, the blood flow from the right superior vena cava was diverted into the left side of the common atrium through an intra-atrial tunnel. Complete atrioventricular septal defect was repaired with modified one-patch method, and the patch divided the common atrium into the right and left atria. She was discharged on postoperative day 11 without obstruction in systemic and pulmonary venous return. Therefore, if all the pulmonary veins drain to the common chamber, intra-atrial rerouting may effectively correct anomalous systemic venous connection in the septation of the common atrium.

Blood flow dynamics with four-dimensional flow cardiovascular magnetic resonance in patients with aortic stenosis before and after transcatheter aortic valve replacement.
Hirokazu Komoriyama, Kiwamu Kamiya, Toshiyuki Nagai, Noriko Oyama-Manabe, Satonori Tsuneta, Yuta Kobayashi, Yoshiya Kato, Miwa Sarashina, Kazunori Omote, Takao Konishi, Takuma Sato, Shingo Tsujinaga, Hiroyuki Iwano, Yasushige Shingu, Satoru Wakasa, Toshihisa Anzai
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 23, 1, 81, 81, 28 Jun. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: Pre- and post-procedural hemodynamic changes which could affect adverse outcomes in aortic stenosis (AS) patients who undergo transcatheter aortic valve replacement (TAVR) have not been well investigated. Four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) enables accurate analysis of blood flow dynamics such as flow velocity, flow pattern, wall shear stress (WSS), and energy loss (EL). We sought to examine the changes in blood flow dynamics of patients with severe AS who underwent TAVR. METHODS: We examined 32 consecutive severe AS patients who underwent TAVR between May 2018 and June 2019 (17 men, 82 ± 5 years, median left ventricular ejection fraction 61%, 6 self-expanding valve), after excluding those without CMR because of a contraindication or inadequate imaging from the analyses. We analyzed blood flow patterns, WSS and EL in the ascending aorta (AAo), and those changes before and after TAVR using 4D flow CMR. RESULTS: After TAVR, semi-quantified helical flow in the AAo was significantly decreased (1.4 ± 0.6 vs. 1.9 ± 0.8, P = 0.002), whereas vortical flow and eccentricity showed no significant changes. WSS along the ascending aortic circumference was significantly decreased in the left (P = 0.038) and left anterior (P = 0.033) wall at the basal level, right posterior (P = 0.011) and left (P = 0.010) wall at the middle level, and right (P = 0.012), left posterior (P = 0.019) and left anterior (P = 0.028) wall at the upper level. EL in the AAo was significantly decreased (15.6 [10.8-25.1 vs. 25.8 [18.6-36.2]] mW, P = 0.012). Furthermore, a significant negative correlation was observed between EL and effective orifice area index after TAVR (r = - 0.38, P = 0.034). CONCLUSIONS: In severe AS patients undergoing TAVR, 4D flow CMR demonstrates that TAVR improves blood flow dynamics, especially when a larger effective orifice area index is obtained.

Trehalose preconditioning for transient global myocardial ischemia in rats.
Norihiro Ando, Yasushige Shingu, Kenichiro Suno, Satoru Wakasa
Biochemical and biophysical research communications, 548, 14, 19, 09 Apr. 2021, [International Magazine]
English, Scientific journal, Autophagy is an intracellular pathway that degrades unnecessary proteins and organelles and provides energy substrates during cellular ischemic conditions. Although pharmacological myocardial preconditioning with an autophagy inducer has been reported to protect cells against ischemic reperfusion (I/R), the effects of preconditioning using naturally occurring substances are still unknown. We aimed to examine whether autophagic preconditioning with trehalose improves cardiac function after myocardial stunning by global ischemia in rats. Rat hearts were perfused by oxygenized Krebs Henseleit (KH) solution in Langendorff system. Ten rats were randomized into the following two groups according to the perfusates during the preconditioning: control (KH solution only, n = 5) and trehalose (KH + 2% trehalose, n = 5). After the 35-min preconditioning period and subsequent 20 min of global ischemia, the hearts were reperfused for 60 min. Cardiac function was assessed during the reperfusion. To evaluate autophagy, myocardial protein expression of microtubule-associated protein light chain 3 (LC3) II was evaluated by western blotting. During I/R, a systolic functional parameter, maximum dP/dt was significantly higher; meanwhile, coronary flow tended to be higher in the trehalose group than in the control group. Myocardial LC3-II expression after preconditioning was higher in the trehalose group than in the control group and decreased to the control level after I/R. In conclusion, in a rat model of global myocardial ischemia, trehalose preconditioning improved cardiac function during I/R. Further studies would be needed to identify the mechanism and effects of trehalose preconditioning.

Frozen elephant trunk術後早期SINE発生のリスク因子　　　　　　　　　　　　　　　
佐藤 公治, 加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲
日本心臓血管外科学会学術総会抄録集, 51回, OP32, 4, (NPO)日本心臓血管外科学会, Feb. 2021
Japanese

心室拡大による機能性僧帽弁閉鎖不全症の外科治療 左室リモデリングを中心に考える機能性僧帽弁閉鎖不全症に対する外科治療　　　　　　　　　　　　　　　
若狭 哲, 新宮 康栄, 石垣 隆弘, 加藤 伸康, 加藤 裕貴, 大岡 智学
日本心臓血管外科学会学術総会抄録集, 51回, SY3, 4, (NPO)日本心臓血管外科学会, Feb. 2021
Japanese

ラット心筋虚血再灌流モデルにおけるトレハロース・プレコンディショニングの効果　　　　　　　　　　　　　　　
須野 賢一郎, 新宮 康栄, 安東 悟央, 若狭 哲
日本心臓血管外科学会学術総会抄録集, 51回, OP13, 1, (NPO)日本心臓血管外科学会, Feb. 2021
Japanese

小児房室弁(単心室共通房室弁を含む)形成術 右側房室弁にEbstein病様の異形成を合併した共通房室弁閉鎖不全に対する弁形成　　　　　　　　　　　　　　　
加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲
日本心臓血管外科学会学術総会抄録集, 51回, VS2, 4, (NPO)日本心臓血管外科学会, Feb. 2021
Japanese

80歳以上高齢者の急性A型大動脈解離に対する外科手術のリスク因子解析　　　　　　　　　　　　　　　
石垣 隆弘, 新宮 康栄, 若狭 哲
日本心臓血管外科学会学術総会抄録集, 51回, OP19, 4, (NPO)日本心臓血管外科学会, Feb. 2021
Japanese

Arterial switch operation後の死亡・再介入関連因子の検討　　　　　　　　　　　　　　　
稗田 哲也, 加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲
日本心臓血管外科学会学術総会抄録集, 51回, OP28, 1, (NPO)日本心臓血管外科学会, Feb. 2021
Japanese

Frozen elephant trunk術後早期SINE発生のリスク因子　　　　　　　　　　　　　　　
佐藤 公治, 加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲
日本心臓血管外科学会学術総会抄録集, 51回, OP32, 4, (NPO)日本心臓血管外科学会, Feb. 2021
Japanese

Endovascular relining of a Dacron graft for refractory perigraft seroma.
Shinji Abe, Yasuhiro Kamikubo, Yasushige Shingu, Ryo Matsumoto, Makoto Takahira
General thoracic and cardiovascular surgery, 69, 2, 340, 342, Feb. 2021, [Domestic magazines]
English, Scientific journal, Although perigraft seroma (PGS) is a well-known complication of vascular surgery, optimal therapy has not yet been established. A 90-year-old patient underwent a bypass from the right subclavian artery to the left carotid and subclavian arteries for debranching thoracic endovascular aortic repair. Four years post-surgery, computed tomography revealed PGS at the anastomosis site. Percutaneous needle aspiration and surgical drainage were ineffective in treating PGS. We performed a relining procedure using covered stents for the bypass graft that resolved the PGS. This procedure is minimally invasive, avoids graft excision, and can be especially valuable for elderly patients.

Frozen elephant trunk術後dSINEリスクの検討　　　　　　　　　　　　　　　
佐藤 公治, 加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲
日本血管外科学会雑誌, 30, Suppl., O24, 1, (NPO)日本血管外科学会, 2021
Japanese

A Case of Multiple Cardiac Papillary Fibroelastoma in the Aortic Valve
Kubota Takehiro, Shingu Yasushige, Wakasa Satoru
Japanese Journal of Cardiovascular Surgery, 50, 4, 270, 273, The Japanese Society for Cardiovascular Surgery, 2021
Japanese,

We report a case of multiple papillary fibroelastoma (PFE) on the aortic valve. A healthy woman in her 60 s was referred to a nearby doctor with the chief complaint of palpitation and was admitted to our hospital for detailed examination. A mobile tumor was found by transthoracic echo, and she was introduced to us. We undertook excision surgery for her. Initially, it was thought to be a single tumor, and a pedunculated tumor adhering to the central aortic side of the left coronary cusp with a length of 7 mm was removed. After closing the aorta, we recognized a remaining mobile tumor by transesophageal echo. We decided to perform cardiac arrest again, and we recognized one tumor with 6 mm long string-like mobile mass on the right and non-coronary commissure of cardiac side, and a thorn-like mass of about 1.5 mm on the non-coronary cusp of the cardiac side. We removed both tumors from the aortic valve using shaving resection and preserved the aortic valve. All of these were found to be PFE pathologically as if they were three tumors that followed the developmental stage of PFE. After surgery, PFE recurrence is extremely rare. In the case of a pedunculated tumor, it is possible to remove the tumor and preserve the valve. However, as in this case, if both sides of the valve were not carefully inspected, it can be overlooked. In addition, small tumor resection could avoid the risk of new cerebral infarction and myocardial infarction due to recurrence and could avoid reoperation.

80歳以上高齢者の急性A型大動脈解離に対する外科手術のリスク因子解析　　　　　　　　　　　　　　　
石垣 隆弘, 新宮 康栄, 若狭 哲, HOCARD members
日本血管外科学会雑誌, 30, Suppl., O11, 1, (NPO)日本血管外科学会, 2021
Japanese

Frozen elephant trunk術後dSINEリスクの検討　　　　　　　　　　　　　　　
佐藤 公治, 加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲
日本血管外科学会雑誌, 30, Suppl., O24, 1, (NPO)日本血管外科学会, 2021
Japanese

止血デバイスを用いた経皮的腹部ステントグラフト内挿術の創合併症予防効果の検討　　　　　　　　　　　　　　　
鍋島 龍一, 石垣 隆弘, 加藤 伸康, 加藤 裕貴, 新宮 康栄, 大岡 智学, 若狭 哲
日本血管外科学会雑誌, 30, Suppl., O37, 1, (NPO)日本血管外科学会, 2021
Japanese

二心室修復可能な心疾患に対する姑息的右室流出路再建術8例の検討　　　　　　　　　　　　　　　
加藤 伸康, 橘 剛, 新宮 康栄, 若狭 哲, 加藤 裕貴, 大岡 智学, 山澤 弘州, 武田 充人
日本小児循環器学会雑誌, 36, Suppl.2, s2, 383, (NPO)日本小児循環器学会, Nov. 2020
Japanese

長期VAD治療の現状と課題 新規大動脈閉鎖不全と感染症に対する治療戦略
大岡 智学, 布施川 真哲, 鍋島 龍二, 小市 裕太, 稗田 哲也, 安東 悟央, 石垣 隆弘, 佐藤 公治, 加藤 伸康, 加藤 裕貴, 新宮 康栄, 若狭 哲
日本胸部外科学会定期学術集会, 73回, CLO19, 1, (一社)日本胸部外科学会, Oct. 2020
Japanese

胸腹部大動脈瘤手術時の肋間動脈再建法の工夫と脊髄保護 internal cuff reimplantation法の有用性
佐藤 公治, 杉本 聡, 加藤 伸康, 新宮 康栄, 杉木 宏司, 加藤 裕貴, 大岡 智学, 若狭 哲
日本胸部外科学会定期学術集会, 73回, CTA1, 5, (一社)日本胸部外科学会, Oct. 2020
Japanese

感染症対策を見据えたVAD治療の進歩と臨床展開 VAD関連感染症の治療戦略 大網と局所閉鎖陰圧療法の適用と有効性　　　　　　　　　　　　　　　
大岡 智学, 布施川 真哲, 鍋島 龍二, 小市 裕太, 稗田 哲也, 石垣 隆弘, 佐藤 公治, 加藤 伸康, 新宮 康栄, 若狭 哲
人工臓器, 49, 2, S, 53, (一社)日本人工臓器学会, Oct. 2020
Japanese

Refractory Right Ventricular Failure in a Patient with Emery-Dreifuss Muscular Dystrophy.
Yasuyuki Chiba, Arata Fukushima, Motoki Nakao, Yuta Kobayashi, Takahiro Ishigaki, Taro Tenma, Kiwamu Kamiya, Yasushige Shingu, Tomonori Ooka, Yoshiro Matsui, Toshihisa Anzai
Internal medicine (Tokyo, Japan), 59, 10, 1277, 1281, 15 May 2020, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, A 23-year-old man had progressive muscle weakness and Emery-Dreifuss muscular dystrophy (EDMD) due to a LMNA (lamin A/C) mutation. Congestive heart failure diagnosed at 19 years of age. Maximal drug treatment/cardiac resynchronization failed to improve the cardiac function. He was therefore hospitalized due to heart failure. Despite extracorporeal membrane oxygenation, he developed severe right heart dysfunction and died (multiple organ failure). A cardiac lesion's presence determines the prognosis of EDMD. While there are many arrhythmia reports, few reports on heart failure (particularly severe heart failure requiring cardiac transplantation) have been published. Right heart function monitoring and early ventricular-assist device use plus right heart support considering heart transplantation are important.

Persistent Fifth Aortic Arch with Left Ventricular Dysfunction and Left Bronchial Obstruction.
Nobuyasu Kato, Tsuyoshi Tachibana, Hidetsugu Asai, Noriyoshi Ebuoka, Yasushige Shingu, Tomonori Ooka, Hiroki Kato, Satoru Wakasa
The Annals of thoracic surgery, 110, 5, e361-e363, 18 Apr. 2020, [Peer-reviewed], [International Magazine]
English, Persistent fifth aortic arch is a rare anomaly in congenital heart disease, which is often associated with aortic obstructive diseases. We report a 7-month-old infant diagnosed persistent fifth aortic arch (AA) with left ventricular dysfunction along with left bronchial malacia due to compression from own heart. Surgical repair was performed including AA reconstruction using the 5th-AA as an in-situ flap to enlarge the 4th-AA with end-to-end anastomosis, and external stenting for the left bronchial malacia. Postoperative courses were uneventful. On computed tomography, a reconstructed aortic arch without obstruction and an expanded left bronchus were seen.

Type IIエンドリークに対する腰動脈結紮・ステントグラフト温存瘤縫縮術　　　　　　　　　　　　　　　
小市 裕太, 新宮 康栄, 新井 洋輔, 石垣 隆弘, 安東 悟央, 稗田 哲也, 佐藤 公治, 加藤 伸康, 関 達也, 加藤 裕貴, 若狭 哲, 大岡 智学
日本インターベンショナルラジオロジー学会雑誌, 34, 4, 298, 298, (一社)日本インターベンショナルラジオロジー学会, Apr. 2020
Japanese

心筋症に対する外科的左室負荷軽減と「アジュバント治療」の可能性　　　　　　　　　　　　　　　
新宮 康栄, 稗田 哲也, 加藤 伸康, 若狭 哲, 大岡 智学
日本心臓血管外科学会学術総会抄録集, 50回, PR20, 1, (NPO)日本心臓血管外科学会, Mar. 2020
Japanese

機能性僧帽弁逆流に対する置換術式による左室内エネルギー損失の違い VFMによる検討　　　　　　　　　　　　　　　
石垣 隆弘, 新宮 康栄, 加藤 伸康, 若狭 哲, 大岡 智学, 大川 洋平, 山田 陽, 高橋 順一郎, 松居 喜郎
日本心臓血管外科学会学術総会抄録集, 50回, O9, 1, (NPO)日本心臓血管外科学会, Mar. 2020
Japanese

肺動脈血栓内膜摘除は慢性血栓塞栓性肺高血圧症に対する標準治療であり続けられるか?　　　　　　　　　　　　　　　
大岡 智学, 小市 裕太, 稗田 哲也, 荒木 大, 石垣 隆弘, 安東 悟央, 佐藤 公治, 加藤 伸康, 新宮 康栄, 若狭 哲, 加藤 裕貴
日本心臓血管外科学会学術総会抄録集, 50回, O11, 4, (NPO)日本心臓血管外科学会, Mar. 2020
Japanese

当院における完全型房室中隔欠損症に対する二心室修復の成績　　　　　　　　　　　　　　　
稗田 哲也, 加藤 伸康, 小市 裕太, 安東 悟央, 荒木 大, 石垣 隆弘, 佐藤 公治, 新宮 康栄, 若狭 哲, 加藤 裕貴, 大岡 智学, 橘 剛
日本心臓血管外科学会学術総会抄録集, 50回, P2, 3, (NPO)日本心臓血管外科学会, Mar. 2020
Japanese

Autophagy during left ventricular redilation after ventriculoplasty: Insights from a rat model of ischemic cardiomyopathy.
Satoshi Sugimoto, Yasushige Shingu, Torsten Doenst, Tomoji Yamakawa, Hidetsugu Asai, Satoru Wakasa, Yoshiro Matsui
The Journal of thoracic and cardiovascular surgery, 163, 1, e33-e40, 19 Feb. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: Myocardial autophagy has been recognized as an important factor in heart failure. It is not known whether changes in ventricular geometry by left ventriculoplasty influence autophagy in ischemic cardiomyopathy. We hypothesized that myocardial autophagy plays an important role in left ventricular (LV) redilation after ventriculoplasty. METHODS: Four weeks after ligation of the left anterior descending artery, ventriculoplasty or sham operation was performed. The animals were euthanized at 2 days (early) or 28 days (late) after the second operation. Ventricular autophagy was evaluated by protein expression of microtubule-associated protein light chain 3 II, an autophagosome marker. Cardiomyocyte area was assessed by histologic examination. LV function was evaluated by echocardiography. To examine the implications of autophagy, an autophagy inhibitor (3-methyladenine) was injected intraperitoneally for 3 weeks before sacrifice. RESULTS: The LV was reduced in size early and redilated late after ventriculoplasty. LV systolic function was improved early and later worsened after ventriculoplasty. Light chain 3 II expression decreased early after ventriculoplasty and increased in the late period. Myocyte area increased from the early to late stage after ventriculoplasty. Autophagic inhibition exaggerated the increased myocyte hypertrophy and LV redilation. CONCLUSIONS: In a rat model of myocardial infarction, autophagy decreased early after ventriculoplasty and increased again during LV redilation. These results provide new insights into the mechanism underlying the late failure of ventriculoplasty.

ステントグラフト温存型動脈瘤切除術の中間成績(Midterm results of stent graft-conserving aneurysmorrhaphy)　　　　　　　　　　　　　　　
佐藤 公治, 若狭 哲, 新宮 康栄, 杉木 宏司, 加藤 裕貴, 大岡 智学
日本血管外科学会雑誌, 29, Suppl., SY11, 5, (NPO)日本血管外科学会, 2020
English

ステントグラフト温存型動脈瘤切除術の中間成績(Midterm results of stent graft-conserving aneurysmorrhaphy)　　　　　　　　　　　　　　　
佐藤 公治, 若狭 哲, 新宮 康栄, 杉木 宏司, 加藤 裕貴, 大岡 智学
日本血管外科学会雑誌, 29, Suppl., SY11, 5, (NPO)日本血管外科学会, 2020
English

Correlation between increased atrial expression of genes related to fatty acid metabolism and autophagy in patients with chronic atrial fibrillation.
Yasushige Shingu, Shingo Takada, Takashi Yokota, Ryosuke Shirakawa, Akira Yamada, Tomonori Ooka, Hiroki Katoh, Suguru Kubota, Yoshiro Matsui
PloS one, 15, 4, e0224713, 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, Atrial metabolic disturbance contributes to the onset and development of atrial fibrillation (AF). Autophagy plays a role in maintaining the cellular energy balance. We examined whether atrial gene expressions related to fatty acid metabolism and autophagy are altered in chronic AF and whether they are related to each other. Right atrial tissue was obtained during heart surgery from 51 patients with sinus rhythm (SR, n = 38) or chronic AF (n = 13). Preoperative fasting serum free-fatty-acid levels were significantly higher in the AF patients. The atrial gene expression of fatty acid binding protein 3 (FABP3), which is involved in the cells' fatty acid uptake and intracellular fatty acid transport, was significantly increased in AF patients compared to SR patients; in the SR patients it was positively correlated with the right atrial diameter and intra-atrial electromechanical delay (EMD), parameters of structural and electrical atrial remodeling that were evaluated by an echocardiography. In contrast, the two groups' atrial contents of diacylglycerol (DAG), a toxic fatty acid metabolite, were comparable. Importantly, the atrial gene expression of microtubule-associated protein light chain 3 (LC3) was significantly increased in AF patients, and autophagy-related genes including LC3 were positively correlated with the atrial expression of FABP3. In conclusion, in chronic AF patients, the atrial expression of FABP3 was upregulated in association with autophagy-related genes without altered atrial DAG content. Our findings may support the hypothesis that dysregulated cardiac fatty acid metabolism contributes to the progression of AF and induction of autophagy has a cardioprotective effect against cardiac lipotoxicity in chronic AF.

Perioperative changes of the slope in the preload recruitable stroke work relationship by a single-beat technique after mitral valve surgery in functional mitral regurgitation with non-ischemic dilated cardiomyopathy.
Takahiro Ishigaki, Yasushige Shingu, Nobuyasu Katoh, Satoru Wakasa, Hiroki Katoh, Tomonori Ooka, Suguru Kubota, Yoshiro Matsui
General thoracic and cardiovascular surgery, 68, 1, 30, 37, Jan. 2020, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, OBJECTIVES: The slope in the preload recruitable stroke work relationship is a highly linear, load-insensitive contractile parameter. However, the perioperative change of the slope has not been reported before. We examined the perioperative slope from a steady-state single beat in patients with functional mitral regurgitation and assessed the correlation with brain natriuretic peptide (BNP) levels. METHODS: The study included 16 patients with non-ischemic dilated cardiomyopathy and refractory heart failure: 10 patients underwent mitral valve plasty and left ventricular plasty (MVP + LVP group) and 6 patients who underwent mitral valve replacement and papillary muscle tugging approximation (MVR + PMTA group). The left ventricular ejection fraction was assessed by the modified Simpson method; the slope was assessed by the single-beat technique using transthoracic echocardiography. BNP levels were measured by chemiluminescent immunoassay. RESULTS: The left ventricular ejection fraction and slope did not significantly change from pre- to early post-surgery in the MVP + LVP group. Both the left ventricular ejection fraction and slope significantly increased 6 months after surgery in the MVR + PMTA group. Postoperative BNP level was low in the MVR + PMTA group. While the postoperative left ventricular ejection fraction did not correlate with BNP levels, the postoperative slope significantly correlated with BNP level after surgery in the MVP + LVP group and in the total functional mitral regurgitation group. CONCLUSIONS: The change of slope was dependent on surgical procedures. In functional mitral regurgitation, the slope may be a more sensitive parameter in reflecting the left ventricular contractile function than the left ventricular ejection fraction.

肉眼的に乳頭状線維弾性腫と鑑別が困難であったvilloustype左房粘液腫の1例
石垣 隆弘, 新宮 康栄, 加藤 伸康, 若狭 哲, 大岡 智学, 加藤 裕貴, 若林 健人, 三橋 智子, 松居 喜郎
北海道外科雑誌, 64, 2, 207, 207, 北海道外科学会, Dec. 2019
Japanese

カルニチンによる心臓弁膜症手術後の心房細動の予防(単群介入試験)
新宮 康栄, 小市 裕太, 稗田 哲也, 新井 洋輔, 安東 悟央, 石垣 隆弘, 佐藤 公治, 加藤 伸康, 若狭 哲, 大岡 智学
北海道外科雑誌, 64, 2, 209, 209, 北海道外科学会, Dec. 2019
Japanese

長期(3年以上)VAD治療の課題と対策 長期植込型補助人工心臓治療の現状、課題、そして対策　　　　　　　　　　　　　　　
大岡 智学, 加藤 伸康, 新宮 康栄, 若狭 哲, 加藤 裕貴, 松居 喜朗, 寒河江 磨, 矢萩 亮児, 櫛引 勝年, 加藤 美香
人工臓器, 48, 2, S, 75, (一社)日本人工臓器学会, Oct. 2019
Japanese

Risk factors for residual mitral regurgitation after aortic valve replacement in patients with severe aortic valve stenosis and moderate mitral regurgitation.
Yasushige Shingu, Hiroyuki Iwano, Tatsuya Murakami, Nobuyasu Katoh, Tomonori Ooka, Hiroki Katoh, Suguru Kubota, Yoshiro Matsui
General thoracic and cardiovascular surgery, 67, 10, 849, 854, Oct. 2019, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, OBJECTIVES: While it was reported that patients with residual moderate mitral regurgitation (MR) after surgical aortic valve replacement (SAVR) had a poorer prognosis than those without it, the risk factors for residual MR have not been fully elucidated. The aim of the study was to evaluate risk factors for residual MR after SAVR. METHODS: Of the 222 patients who underwent isolated SAVR from 2001 to 2018, 33 (11 men; age: 74 ± 7 years) had functional moderate MR before surgery. The risk factors for residual MR were evaluated by comparing patients with residual moderate MR (n = 11, 33%) with those who exhibited improved post-surgery MR (n = 22, 67%). RESULTS: The left atrial diameter was significantly larger in the residual MR group (51 ± 7 mm) than in the improved MR group (46 ± 5 mm; P = 0.049). The mean pressure gradient at the aortic valve was significantly smaller in the residual MR group (52 ± 18 mmHg) than in the improved MR group (69 ± 22 mmHg; P = 0.043). A ratio of left atrial diameter (mm) and mean aortic valve pressure gradient (mmHg) greater than 0.9 predicted residual MR with a sensitivity of 70% and a specificity of 74% (area under the ROC curve: 0.779; P = 0.015). CONCLUSIONS: In patients with severe aortic valve stenosis and moderate MR, a high ratio of preoperative left atrial diameter and mean aortic valve pressure gradient would be a parameter predicting residual moderate MR post-SAVR.

Abnormal FDG uptake predicting the instability of thoracic aortic aneurysms.
Yasuyuki Chiba, Kiwamu Kamiya, Tadao Aikawa, Hiroyuki Iwano, Toshiyuki Nagai, Takahiro Ishigaki, Yasushige Shingu, Ai Shimizu, Yoshiro Matsui, Toshihisa Anzai
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 27, 5, 1841, 1843, 27 Aug. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal

Norwood Operation of a Neonate with Pentalogy of Cantrell.
Asai H, Shingu Y, Ito N, Tachibana T
The Annals of thoracic surgery, 109, 2, e135-e136, Jun. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Surgical correction of Cantrell syndrome is often associated with an extremely high mortality rate due to the possibility of wound infection or the severity of cardiac anomalies. We report a case of Norwood operation and repositioning of the heart successfully performed 1 day after the birth of a neonate with pentalogy of Cantrell. The patient had double-outlet right ventricle, subaortic stenosis, aortic valve stenosis, hypoplastic aortic arch, and coarctation of the aorta. The patient underwent the Glenn operation at the age of 1 year and is now waiting for the Fontan operation.

Papillary Muscle Tugging Approximation for Functional Mitral Regurgitation.
Yoshiro Matsui, Yasushige Shingu, Satoru Wakasa, Tomonori Ooka, Suguru Kubota
The Annals of thoracic surgery, 107, 6, e427-e429, Jun. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, The surgical approach is challenging for patients with severe functional mitral regurgitation with nonischemic/ischemic dilated cardiomyopathy who are unsuitable for heart transplantation or ventricular assist device implantation. We developed a new surgical treatment named papillary muscle tugging approximation combined with mitral valve replacement. This technique is safe and feasible, with excellent midterm outcomes.

Mechanical properties of a new thermally deformable mitral valve annuloplasty ring and its effects on the mitral valve.
Tatsuya Seki, Katsuyoshi Jimuro, Yasushige Shingu, Satoru Wakasa, Hiroki Katoh, Tomonori Ooka, Tsuyoshi Tachibana, Suguru Kubota, Toshiro Ohashi, Yoshiro Matsui
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 22, 2, 126, 133, Jun. 2019, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Ideally, an annuloplasty ring's shape should be changed intraoperatively if mitral valve repair is unsuccessful because of a short coaptation length or systolic anterior motion. Several post-implantation adjustable rings have been developed, but they are not freely deformable and are unsuitable for asymmetric repair of the valvular annulus. We developed a novel thermally deformable mitral annuloplasty ring to address these problems and assessed the ring's mechanical properties and its effect on the mitral valve anatomy. This ring was made of polycaprolactone. Tensile and bending tests were performed to evaluate the ring's mechanical properties. The ratio of the transverse and septal-lateral length was determined as 4:3. Using 10 pig hearts, we measured the post-deformation coaptation length and minimum distance from the coaptation to the ventricular septum, which is a factor of abnormal systolic anterior motion of the mitral valve. In the mechanical tests, the ring's yield point was greater than the deformation force of the annulus in humans. In pigs with deformation from "4:3" to "4:2", the coaptation length was significantly increased in each mitral valve part. In pigs with deformation from "4:3" to "4:4", the minimum distance from the coaptation to the ventricular septum was significantly increased. Asymmetrical ring deformation increased the coaptation length only at the deformed area. In conclusion, this new thermally deformable mitral annuloplasty ring could be "order-made" to effectively change the coaptation length in all parts of the mitral valve and the distance from the coaptation to septum post-deformation via intraoperative heating.

Re-do mitral valve replacement for a bioprosthetic valve with central transvalvular leakage in a patient with ischemic cardiomyopathy: a case report.
Tatsuya Seki, Yasushige Shingu, Satoru Wakasa, Hiroki Katoh, Tomonori Ooka, Tsuyoshi Tachibana, Suguru Kubota, Yoshiro Matsui
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 22, 2, 177, 180, Jun. 2019, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Transvalvular leakage (TVL) of a prosthetic heart valve is not negligible regurgitant flow in patients with critically low contractile function. Although the opening function of prosthetic valves has been reported, its closing function is not well understood. A man in his 70 s had a history of mitral valve replacement (MVR) with a Magna Mitral® valve for ischemic mitral valve regurgitation. He presented with dyspnea 2 years postoperatively. Echocardiography showed moderate TVL. The pulmonary capillary wedge pressure and cardiac index were 37 mmHg and 1.65 L/min/m2, respectively. Because we considered his TVL relevant, we performed re-do MVR with a mechanical valve and papillary muscle approximation and suspension ("papillary muscle tugging approximation"). His cardiac function improved postoperatively; he was discharged with New York Heart Association class I. For MVR in patients with critically low contractile function, prosthetic valves, such as mechanical valves, with small TVL are recommended.

Segmental arterial mediolysis(SAM)による巨大脾動脈瘤に対する手術経験　　　　　　　　　　　　　　　
松木田 瞭, 岡村 圭祐, 水沼 謙一, 山村 喜之, 真木 健裕, 細井 勇人, 中西 喜嗣, 浅野 賢道, 野路 武寛, 倉島 庸, 海老原 裕磨, 村上 壮一, 中村 透, 土川 貴裕, 七戸 俊明, 平野 聡, 杉本 聡, 新宮 康栄
日本外科学会定期学術集会抄録集, 119回, RS, 10, (一社)日本外科学会, Apr. 2019
Japanese

心外導管型Fontan conversionの治療成績と中遠隔期の効果　　　　　　　　　　　　　　　
加藤 伸康, 橘 剛, 新宮 康栄, 大岡 智学, 加藤 裕貴, 久保田 卓, 泉 学, 山澤 弘州, 武田 充人, 松居 喜郎
日本外科学会定期学術集会抄録集, 119回, PS, 5, (一社)日本外科学会, Apr. 2019, [Peer-reviewed]
Japanese

Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis.
Takayuki Nakajima, Takashi Yokota, Yasushige Shingu, Akira Yamada, Yutaka Iba, Kosuke Ujihira, Satoru Wakasa, Tomonori Ooka, Shingo Takada, Ryosuke Shirakawa, Takashi Katayama, Takaaki Furihata, Arata Fukushima, Ryosuke Matsuoka, Hiroshi Nishihara, Flemming Dela, Katsuhiko Nakanishi, Yoshiro Matsui, Shintaro Kinugawa
Scientific reports, 9, 1, 3535, 3535, 05 Mar. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Epicardial adipose tissue (EAT), a source of adipokines, is metabolically active, but the role of EAT mitochondria in coronary artery disease (CAD) has not been established. We investigated the association between EAT mitochondrial respiratory capacity, adiponectin concentration in the EAT, and coronary atherosclerosis. EAT samples were obtained from 25 patients who underwent elective cardiac surgery. Based on the coronary angiographycal findings, the patients were divided into two groups; coronary artery disease (CAD; n = 14) and non-CAD (n = 11) groups. The mitochondrial respiratory capacities including oxidative phosphorylation (OXPHOS) capacity with non-fatty acid (complex I and complex I + II-linked) substrates and fatty acids in the EAT were significantly lowered in CAD patients. The EAT mitochondrial OXPHOS capacities had a close and inverse correlation with the severity of coronary artery stenosis evaluated by the Gensini score. Intriguingly, the protein level of adiponectin, an anti-atherogenic adipokine, in the EAT was significantly reduced in CAD patients, and it was positively correlated with the mitochondrial OXPHOS capacities in the EAT and inversely correlated with the Gensini score. Our study showed that impaired mitochondrial OXPHOS capacity in the EAT was closely linked to decreased concentration of adiponectin in the EAT and severity of coronary atherosclerosis.

乳児期・小児期に僧帽弁への手術介入を必要としたMarfan症候群4例の経験　　　　　　　　　　　　　　　
加藤 伸康, 橘 剛, 新宮 康栄, 大岡 智学, 加藤 裕貴, 久保田 卓, 山澤 弘州, 武田 充人, 松居 喜郎
日本心臓血管外科学会学術総会抄録集, 49回, [PP, 011], (NPO)日本心臓血管外科学会, Feb. 2019, [Peer-reviewed]
Japanese

先天性左冠動脈開口部閉鎖に対して左冠動脈主幹部再建を施行した2例　　　　　　　　　　　　　　　
新井 洋輔, 加藤 伸康, 橘 剛, 新宮 康栄, 大岡 智学, 加藤 裕貴, 久保田 卓, 武田 充人, 山澤 弘州, 泉 岳, 佐々木 理, 松居 喜郎
日本心臓血管外科学会学術総会抄録集, 49回, [PP, 024], (NPO)日本心臓血管外科学会, Feb. 2019, [Peer-reviewed]
Japanese

心外導管型フォンタンへの移行に加えて自己弁温存大動脈基部置換を併施した一例(A successful surgical case of extra-cardiac Fontan conversion combined with valve-sparing aortic root replacement for PA/IVS and aortic root aneurysm)　　　　　　　　　　　　　　　
加藤 伸康, 橘 剛, 新井 洋輔, 新宮 康栄, 加藤 裕貴, 大岡 智学, 久保田 卓, 泉 学, 山澤 弘州, 武田 充人, 松居 喜郎
日本成人先天性心疾患学会雑誌, 8, 1, 159, 159, 日本成人先天性心疾患学会, Jan. 2019, [Peer-reviewed]
English

Modified total cavopulmonary shunt as a staged Fontan operation.
Hidetsugu Asai, Tsuyoshi Tachibana, Yasushige Shingu, Hiroki Kato, Satoru Wakasa, Yoshiro Matsui
Asian cardiovascular & thoracic annals, 26, 9, 701, 703, Nov. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, The left superior vena cava became occluded in an infant with hypoplastic left heart syndrome. After a bidirectional Glenn procedure, he presented with severe oxygen desaturation and right ventricular dysfunction; the left superior vena cava drained into the inferior vena cava through collateral veins. As salvage therapy, we created a modified total cavopulmonary shunt using only autologous tissue in which the right hepatic vein and inferior vena cava drained into the pulmonary artery via a lateral tunnel in the right atrium. Immediately after surgery, his oxygen saturation increased and right ventricular function improved.

Anticoagulation management during cardiopulmonary bypass in patients with antiphospholipid syndrome.
Tatsuya Seki, Yasushige Shingu, Hiroshi Sugiki, Satoru Wakasa, Hiroki Katoh, Tomonori Ooka, Tsuyoshi Tachibana, Suguru Kubota, Yoshiro Matsui
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 21, 3, 363, 366, Sep. 2018, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Antiphospholipid syndrome (APS) is a complex autoimmune disease often related to systemic lupus erythematosus. Although adequate anticoagulation is important for APS patients during cardiopulmonary bypass, clotting tests can be potentially misleading due to antiphospholipid antibodies. We performed cardiac surgery safely in two APS patients under anticoagulation monitoring determined using preoperative heparin titration. We performed heparin titration for activated clotting time to determine the appropriate heparin concentration during cardiac surgery. We changed the targeted heparin concentration considering each patient's thrombotic risks: 3 U/ml of heparin for a normal-risk APS patient and 5 U/ml for a high-risk APS patient with a history of antiphospholipid-antibody-associated thrombocytopenia. A higher targeted heparin concentration might be necessary for patients with high thrombotic risks.

[Surgical Options for Refractory Heart Failure Patients with Non-ischemic Dilated Cardiomyopathy].
Shingu Y, Ooka T, Tachibana T, Kubota S, Matsui Y
Kyobu geka. The Japanese journal of thoracic surgery, 71, 7, 484, 487, Jul. 2018, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, Surgical strategy for non-ischemic dilated cardiomyopathy (NIDCM) is currently controversial. Subjects were 20 patients who underwent left ventriculoplasty(LVP) from 2006 to 2013 and 6 patients who underwent papillary muscle tugging approximation (PMTA) after 2015. PMTA is a new trans-mitral approach combined with valve replacement without left ventriculotomy. Another group of patients( n=14)who were registered for heart transplantation( HTx) after 2013 was also analyzed for left ventricular assist device(LVAD) free survival. Mw( slope in the preload recruitable stroke work relationship) calculated by single beat technique using echocardiography was employed as a load-independent cardiac functional parameter. The baseline characteristics and Mw were not different between the LVP and PMTA groups. One-year survival was significantly lower in the LVP group(53%)than in the PMTA group(100%)[log-rank:p=0.024]. In the HTx group, early LVAD implantation was necessary in the patients who had low Mw(<20)at the time of registration. In conclusion, PMTA would be one option for NIDCM patients( non-HTx candidates) with severe mitral regurgitation. Early LVAD implantation might be predicted in HTx candidates with low Mw(<20).

GLP-1 Improves Diastolic Function and Survival in Heart Failure with Preserved Ejection Fraction
T. Dung Nguyen, Yasushige Shingu, Paulo A. Amorim, Christina Schenkl, Michael Schwarzer, Torsten Doenst
Journal of Cardiovascular Translational Research, 11, 3, 259, 267, Springer New York LLC, 01 Jun. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal

Surgery for Left Ventricular Outflow Tract Obstruction with a Relatively Thin Interventricular Septum.
Yasushige Shingu, Hiroshi Sugiki, Tomonori Ooka, Hiroki Kato, Satoru Wakasa, Tsuyoshi Tachibana, Yoshiro Matsui
The Thoracic and cardiovascular surgeon, 66, 4, 307, 312, Jun. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: To examine the results of myectomy and mitral valve surgery for systolic anterior motion (SAM) of the mitral valve and left ventricular outflow tract obstruction (LVOTO) with a relatively thin interventricular septum. METHODS: The subjects were 12 patients with SAM and LVOTO. Eight had hypertrophic obstructive cardiomyopathy (HOCM) with a mean interventricular septal thickness of 16 mm. Three had sigmoid septum and one had an unknown etiology. For HOCM, isolated extended myectomy was performed when mitral regurgitation was mild (n = 1) and extended myectomy plus mitral valve surgery was performed when mitral regurgitation was more than mild (n = 4) or primary valve etiologies existed (n = 3). Myectomy was performed for the three cases with sigmoid septum. Myectomy plus height reduction of the posterior mitral leaflet was performed for the one case with the unknown etiology of SAM. RESULTS: In the patients with HOCM, the maximum LVOT pressure gradient significantly decreased from 140 ± 18 to 16 ± 6 and 3 ± 3 mm Hg, while mitral regurgitation significantly decreased from 2.3 ± 0.5 to 0.5 ± 0.3 and 0.4 ± 0.2 at pre-op, early post-op, and last follow-up (3 ± 1 years), respectively. In the other etiologies, the maximum LVOT pressure gradient changed from 56 ± 15 to 25 ± 15 and 5 ± 4 mm Hg; mitral regurgitation changed from 2.0 ± 0.6 to 1.3 ± 0.3 and 1.3 ± 0.8, at pre-op, early post-op, and the last follow-up (3 ± 2 years), respectively. CONCLUSION: Myectomy with mitral valve surgery is an option for SAM and LVOTO in patients with a relatively thin interventricular septum.

Feasibility and limitations of mitral valve repair, with or without left ventricular reconstruction in non-ischemic dilated cardiomyopathy
Yasushige Shingu, Tomonori Ooka, Hiroki Katoh, Tsuyoshi Tachibana, Suguru Kubota, Yoshiro Matsui
Journal of Cardiology, 71, 4, 329, 335, Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai), 01 Apr. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal

Supravalvular aortic stenosis with a chronic type A aortic dissection
Takahiro Ishigaki, Yasushige Shingu, Yoshiro Matsui
Journal of Cardiac Surgery, 33, 4, 196, 198, Blackwell Publishing Inc., 01 Apr. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal

心外膜脂肪組織におけるミトコンドリア機能障害は冠動脈狭窄と関連している(Mitochondrial Dysfunction in Epicardial Adipose Tissue is Associated with Coronary Artery Stenosis)　　　　　　　　　　　　　　　
Nakajima Takayuki, Yokota Takashi, Shingu Yasushige, Yamada Akira, Iba Yutaka, Ujihira Kosuke, Wakasa Satoru, Ooka Tomonori, Takada Shingo, Shirakawa Ryosuke, Furihata Takaaki, Tsuda Masaya, Matsumoto Junichi, Katayama Takashi, Fukushima Arata, Saito Akimichi, Matsuoka Ryosuke, Nishihara Hiroshi, Matsui Yoshiro, Kinugawa Shintaro
日本循環器学会学術集会抄録集, 82回, YIA, 1, (一社)日本循環器学会, Mar. 2018
English

A Single Retrograde Revascularization onto the Superior Mesenteric Artery Using an Artificial Graft for Abdominal Angina: A Case Report.
Tochikubo A, Abe S, Yamakawa T, Yoshida M, Shingu Y, Matsui Y
Annals of vascular diseases, 11, 1, 120, 122, The Editorial Committee of Annals of Vascular Diseases, Mar. 2018, [Peer-reviewed], [Domestic magazines]
English,

A man in his 54 was admitted to our hospital owing to progressive postprandial pain for a month. Computed tomography (CT) scan and angiography revealed severe stenosis and calcification of the celiac artery, superior mesenteric artery, and inferior mesenteric artery. Based on the findings of CT scan and angiography, abdominal angina was established and retrograde revascularization was performed only to the superior mesenteric artery using an artificial graft. After the surgery, he remains free of postprandial abdominal pain.

当院の心外導管型Fontan conversionの治療成績の検討　　　　　　　　　　　　　　　
加藤 伸康, 橘 剛, 浅井 英嗣, 新宮 康栄, 大岡 智学, 加藤 裕貴, 久保田 卓, 山澤 弘州, 武田 充人, 松居 喜郎
日本心臓血管外科学会学術総会抄録集, 48回, 716, 716, (NPO)日本心臓血管外科学会, Feb. 2018, [Peer-reviewed]
Japanese

Ex utero intrapartum treatment-to-extracorporeal membrane oxygenation followed by cardiac operation for truncus arteriosus communis
Hidetsugu Asai, Tsuyoshi Tachibana, Yasushige Shingu, Yoshiro Matsui
Interactive Cardiovascular and Thoracic Surgery, 26, 2, 353, 354, Oxford University Press, 01 Feb. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal

Decreased gene expression of fatty acid binding protein 3 in the atrium of patients with new onset of atrial fibrillation in cardiac perioperative phase
Yasushige Shingu, Takashi Yokota, Shingo Takada, Haruki Niwano, Tomonori Ooka, Hiroki Katoh, Tsuyoshi Tachibana, Suguru Kubota, Yoshiro Matsui
Journal of Cardiology, 71, 1, 65, 70, Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai), 01 Jan. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal

Immunohistochemical identification of Propionibacterium acnes in granuloma and inflammatory cells of myocardial tissues obtained from cardiac sarcoidosis patients
Naoya Asakawa, Keisuke Uchida, Mamoru Sakakibara, Kazunori Omote, Keiji Noguchi, Yusuke Tokuda, Kiwamu Kamiya, Kanako C. Hatanaka, Yoshihiro Matsuno, Shiro Yamada, Kyoko Asakawa, Yuichiro Fukasawa, Toshiyuki Nagai, Toshihisa Anzai, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Masanori Hirota, Makoto Orii, Takashi Akasaka, Kenta Uto, Yasushige Shingu, Yoshiro Matsui, Shin-Ichiro Morimoto, Hiroyuki Tsutsui, Yoshinobu Eishi
PLOS ONE, 12, 7, e0179980, Jul. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal

腹部大動脈瘤破裂におけるopen repairとEVARの治療成績 多施設共同研究　　　　　　　　　　　　　　　
佐藤 公治, 新宮 康栄, 石橋 義光, 大川 洋平, 上久保 康弘, 久保田 卓, 須藤 幸雄, 牧野 裕, 松浦 弘司, 丸山 隆史, 村上 達哉, 本橋 雅壽, 山川 智士, 松居 喜郎
日本外科学会定期学術集会抄録集, 117回, SF, 5, (一社)日本外科学会, Apr. 2017
Japanese

胸腹部大動脈瘤術後脊髄障害の発生におけるAdamkiewicz動脈開存性の意義　　　　　　　　　　　　　　　
若狭 哲, 佐藤 公治, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
日本外科学会定期学術集会抄録集, 117回, SF, 7, (一社)日本外科学会, Apr. 2017
Japanese

心外膜脂肪組織のミトコンドリア機能障害は冠動脈狭窄と関連する(Mitochondrial Dysfunction in Epicardial Adipose Tissue is Associated with Coronary Artery Stenosis)　　　　　　　　　　　　　　　
中島 孝之, 横田 卓, 新宮 康栄, 山田 陽, 伊庭 裕, 若狭 哲, 大岡 智学, 高田 真吾, 白川 亮介, 降旗 高明, 津田 正哉, 松本 純一, 片山 貴史, 福島 新, 松居 喜郎, 絹川 真太郎
日本循環器学会学術集会抄録集, 81回, PJ, 075, (一社)日本循環器学会, Mar. 2017
English

機能的単心室における一側肺動脈低形成症例の検討　　　　　　　　　　　　　　　
古川 夕里香, 橘 剛, 浅井 英嗣, 安東 悟央, 荒木 大, 村瀬 亮太, 杉本 聡, 太安 孝允, 佐藤 公治, 新宮 康栄, 加藤 裕貴, 大岡 智学, 松居 喜郎
日本心臓血管外科学会学術総会抄録集, 47回, 544, 544, (NPO)日本心臓血管外科学会, Feb. 2017
Japanese

当科におけるHLHS/HLHS variant外科治療の工夫　　　　　　　　　　　　　　　
橘 剛, 浅井 英嗣, 古川 夕里香, 安東 悟央, 村瀬 亮太, 杉本 聡, 佐藤 公治, 新宮 康栄, 大岡 智学, 松居 喜郎
日本心臓血管外科学会学術総会抄録集, 47回, 769, 769, (NPO)日本心臓血管外科学会, Feb. 2017
Japanese

大動脈全弓部置換術における循環停止期間を予測する　　　　　　　　　　　　　　　
佐藤 公治, 若狭 哲, 浅井 英嗣, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
日本心臓血管外科学会学術総会抄録集, 47回, 420, 420, (NPO)日本心臓血管外科学会, Feb. 2017
Japanese

TypeIIエンドリークに対するステントグラフト温存直達手術　　　　　　　　　　　　　　　
佐藤 公治, 新宮 康栄, 浅井 英嗣, 太安 孝允, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
日本心臓血管外科学会学術総会抄録集, 47回, 872, 872, (NPO)日本心臓血管外科学会, Feb. 2017
Japanese

Left-Ventricular Plication Reduces Wall Stress and Cardiomyocyte Hypertrophy in a Rat Model of Ischemic Cardiomyopathy
Hidetsugu Asai, Yasushige Shingu, Tomoji Yamakawa, Haruki Niwano, Satoru Wakasa, Tomonori Ooka, Hiroki Kato, Tsuyoshi Tachibana, Yoshiro Matsui
EUROPEAN SURGICAL RESEARCH, 58, 1-2, 69, 80, Feb. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal

Mitochondrial dysfunction in epicardial adipose tissue; possible role in progression of coronary artery disease
Yasushige Shingu
European Heart Journal, 2017
Scientific journal

Waterston手術後44年後に肺動脈瘤切迫破裂で発症したPA/VSDの1例
安東 悟央, 古川 夕里香, 村瀬 亮太, 杉本 聡, 佐藤 公治, 太安 孝允, 新宮 康栄, 若狭 哲, 加藤 裕貴, 大岡 智学, 橘 剛, 松居 喜郎
北海道外科雑誌, 61, 2, 197, 188, 北海道外科学会, Dec. 2016
Japanese

EVAR術後のsuprarenal stentに起因する仮性動脈瘤のため胸腹部大動脈置換術を要した1例　　　　　　　　　　　　　　　
佐藤 公治, 新宮 康栄, 古川 夕里香, 安東 悟央, 荒木 大, 杉本 聡, 村瀬 亮太, 浅井 英嗣, 太安 孝允, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
北海道外科雑誌, 61, 2, 188, 188, 北海道外科学会, Dec. 2016
Japanese

Surgery for acute exacerbation of chronic mesenteric ischemia: a case report.
Abe S, Yamakawa T, Kawashima H, Yoshida M, Takanashi S, Kashiyama M, Ishigooka M, Shingu Y, Matsui Y
Surgical case reports, 2, 1, 146, 146, Springer, Dec. 2016, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Chronic mesenteric ischemia (CMI) is a rare disease; however, symptomatic CMI has a risk of acute exacerbation without timely revascularization. CASE PRESENTATION: A 54-year-old man who had had postprandial pain for 6 months was admitted to our hospital because of vomiting and diarrhea. Although the celiac and superior mesenteric arteries were occluded at the proximal portion, contrast enhancement of the bowel wall was good in contrast-enhanced computed tomography (CECT). Endoscopic examination revealed only a healed gastric ulcer and slight mucosal erosions in the colon. He was diagnosed as having acute enteritis or inflammatory digestive disease and observed with conservative therapy, which improved his acute symptoms. On hospitalization day 42, he suddenly complained of lower back pain. CECT showed abdominal free air, which indicated gastrointestinal perforation. Emergency surgery was performed for jejunum resection. Two days later, a second operation was performed for a leak in the anastomotic site of the jejunum. Necrotic change in the small intestinal serosa was also observed and required broad resection of the small intestine. He was diagnosed with acute exacerbation of CMI, and we performed surgical retrograde bypass to the gastroduodenal artery using a saphenous vein graft as the third operation. After the surgery, he was free from digestive symptoms and was discharged. CONCLUSIONS: When patients complain of chronic and gradual digestive symptoms, we should always consider symptomatic CMI. Timely mesenteric revascularization is important for symptomatic CMI before severe complications occur.

鬱血性肝障害を合併した心臓手術に対する手術成績
杉本 聡, 新宮 康栄, 村瀬 亮太, 佐藤 公治, 浅井 英嗣, 太安 孝允, 小林 一哉, 大岡 智学, 加藤 裕貴, 若狭 哲, 橘 剛, 松居 喜郎
北海道外科雑誌, 61, 1, 104, 105, 北海道外科学会, Jun. 2016
Japanese

企業製オープンステントグラフトの早期成績
佐藤 公治, 若狭 哲, 飯島 誠, 小林 一哉, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
北海道外科雑誌, 61, 1, 106, 106, 北海道外科学会, Jun. 2016
Japanese

[Unicuspid Aortic Valve Stenosis Combined with Aortic Coarctation;Report of a Case].
Takehiro Kubota, Satoru Wakasa, Yasushige Shingu, Yoshiro Matsui
Kyobu geka. The Japanese journal of thoracic surgery, 69, 6, 467, 70, Jun. 2016, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, Unicuspid aortic valve in an adult is extremely rare. In addition, 90% of the patients with aortic coarctation are reported to die before the age 50. A 60-year-old woman was admitted to our hospital for further examination of exertional dyspnea which had begun one year before. She had been under medical treatment for hypertension since early thirties, and had been also diagnosed with moderate aortic stenosis at 50 years of age. She was at 1st diagnosed with aortic coarctation combined with bicuspid aortic valve stenosis. The aortic valve was then found unicuspid and was replaced under cardiopulmonary bypass with perfusion to both the ascending aorta and the femoral artery. Repair of aortic coarctation was performed 3 months later through left thoracotomy without extracorporeal circulation due to the rich collateral circulation. She had no postoperative complications, and hypertension as well as ankle-brachial index improved to the normal levels.

異種心膜パッチを用いたintervalvular fibrous body再建を要した弁手術の検討　　　　　　　　　　　　　　　
大岡 智学, 村瀬 亮太, 杉本 聡, 佐藤 公治, 浅井 英嗣, 飯島 誠, 小林 一哉, 新宮 康栄, 若狭 哲, 橘 剛, 松居 喜郎
日本外科学会定期学術集会抄録集, 116回, OP, 7, (一社)日本外科学会, Apr. 2016
Japanese

大動脈全弓部置換術成績向上の工夫 末梢吻合部位と循環停止時間短縮の観点から　　　　　　　　　　　　　　　
佐藤 公治, 若狭 哲, 飯島 誠, 小林 一哉, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
日本外科学会定期学術集会抄録集, 116回, PS, 1, (一社)日本外科学会, Apr. 2016
Japanese

The significance of the analysis on scalographic pattern for detecting malfunctioning bileaflet valve with the wavelet analysis.
Hiroshi Sugiki, Kenji Sugiki, Tomonori Ooka, Satoru Wakasa, Yasushige Shingu, Tsuyoshi Tachibana, Yoshiro Matsui
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 19, 1, 62, 9, Mar. 2016, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, The authors developed the wavelet analysis system which can detect the splitting of bileaflet mechanical heart valve (BLV) into two spikes on the scalogram, and reported that either consecutive single spike or the split behavior can detect malfunctioning BLV (MBV). The latest study on 12 BLVs suggested that the comparison between two spike areas showed higher potential to detect MBV than the split behavior. The aim of the current study is to review 226 files of BLV sound and to select the suitable scalographic property to differentiate the function of BLV with the split. Eight of 30 MBV files showed consecutive single spike, and the rest of 22 MBV files showed two spikes. Two spike areas can be compared by the following three ratios; the anterior spike area/posterior spike area (Aa/La), its reverse ratio (Pa/Aa) and the smaller spike area/the larger spike ratio (Sa/La). Therefore, the current study compared those three ratios to pursue the suitable ratio to compare two spike areas and its sensitivity to differentiate valve function by the ROC analysis. As a result, the Sa/La was suitable for comparing two spike areas, and only this ratio showed high accuracy to differentiate the function of BVL with the split, and its cutoff value was <0.665. Conclusively, the key for detecting MBV was either consecutive single spike or the mean of Sa/La < 0.665. However, this cutoff point is still tentative due to small number of malfunctioning valves, and other key might be available in future.

[Valvular Heart Disease: Current Treatment and Future Perspectives. Topics: III. Current Treatment: Surgical vs. Medical; 3. Infective endocarditis, 1) Surgical intervention for active infective endocarditis].
Yoshiro Matsui, Satoru Wakasa, Tomonori Ooka, Yasushige Shingu
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 105, 2, 238, 44, 10 Feb. 2016, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal

心筋オートファジー活性化による左室縮小術後の心筋肥大抑制
新宮 康栄
心臓, 48, 12, 1444, 2-1444-2, 公益財団法人 日本心臓財団, 2016
Japanese

3. Infective Endocarditis, 1) Surgical Intervention for Active Infective Endocarditis
Matsui Yoshiro, Wakasa Satoru, Ooka Tomonori, Shingu Yasushige
Nihon Naika Gakkai Zasshi, 105, 2, 238, 244, The Japanese Society of Internal Medicine, 2016
Japanese,

活動期感染性心内膜炎（infective endocarditis：IE）に対する外科治療は，心不全や感染の制御，塞栓症の予防の観点から，適応，手術時期を判断し，感染組織の可及的切除により再感染を予防する．また，脳合併症を呈する場合には，梗塞後出血や新規発症のリスクを考慮に入れたうえで適切な手術時期を決定すべきである．大動脈弁位では弁周囲膿瘍が起こりやすく，周囲組織との解剖学的関係を十分理解し，郭清，再建を行う．僧帽弁位では弁形成の可能性を常に考慮すべきである．

下行大動脈置換時の再建肋間動脈開存性が次回胸腹部大動脈置換時の脊髄血流に与える影響
佐藤 公治, 若狭 哲, 浅井 英嗣, 太安 孝允, 小林 一哉, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
北海道外科雑誌, 60, 2, 204, 204, 北海道外科学会, Dec. 2015
Japanese

大動脈食道瘻の1治験例
杉本 聡, 村瀬 亮太, 佐藤 公治, 浅井 英嗣, 太安 孝允, 小林 一哉, 新宮 康栄, 大岡 智学, 加藤 裕貴, 若狭 哲, 橘 剛, 松居 喜郎
北海道外科雑誌, 60, 2, 204, 205, 北海道外科学会, Dec. 2015
Japanese

EVAR後のType Iaエンドリークに対して中枢側ネックbandingを施行した1例
村瀬 亮太, 新宮 康栄, 杉本 聡, 佐藤 公治, 浅井 英嗣, 太安 孝允, 小林 一哉, 大岡 智学, 加藤 裕貴, 若狭 哲, 橘 剛, 松居 喜郎
北海道外科雑誌, 60, 2, 206, 207, 北海道外科学会, Dec. 2015
Japanese

Triheptanoin Alleviates Ventricular Hypertrophy and Improves Myocardial Glucose Oxidation in Rats With Pressure Overload
T. Dung Nguyen, Yasushige Shingu, Paulo A. Amorim, Michael Schwarzer, Torsten Doenst
JOURNAL OF CARDIAC FAILURE, 21, 11, 906, 915, Nov. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal

腹部大動脈ステントグラフト内挿術後のタイプIIエンドリークに対し、Penumbra Coilを用い塞栓術を行った1例　　　　　　　　　　　　　　　
高橋 文也, 作原 祐介, 吉野 裕紀, 曽山 武士, 阿保 大介, 工藤 與亮, 新宮 康栄, 松居 喜郎
IVR: Interventional Radiology, 30, 3, 273, 273, (一社)日本インターベンショナルラジオロジー学会, Sep. 2015
Japanese

北大関連病院データベース(HOCARD)を用いた腹部大動脈瘤破裂の検討
佐藤 公治, 若狭 哲, 浅井 英嗣, 太安 孝允, 内藤 祐嗣, 小林 一哉, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
北海道外科雑誌, 60, 1, 77, 77, 北海道外科学会, Jun. 2015
Japanese

術後の創部感染におけるトリクロサン含有縫合糸の有用性
稗田 哲也, 佐藤 公治, 浅井 英嗣, 太安 孝允, 小林 一哉, 内藤 裕嗣, 新宮 康栄, 若狭 哲, 加藤 裕貴, 大岡 智学, 橘 剛, 松居 喜郎
北海道外科雑誌, 60, 1, 93, 93, 北海道外科学会, Jun. 2015
Japanese

Hydrofitを用いた大動脈吻合部出血軽減の工夫
若狭 哲, 内藤 祐嗣, 関 達也, 小林 一哉, 佐藤 公治, 新宮 康栄, 大岡 智学, 橘 剛, 松居 喜郎
日本血管外科学会雑誌, 24, 3, 349, 349, (NPO)日本血管外科学会, May 2015
Japanese

段階的胸腹部大動脈置換時の脊髄保護 胸部下行置換時の肋間動脈閉鎖が与える影響
佐藤 公治, 若狭 哲, 浅井 英嗣, 太安 孝允, 内藤 祐嗣, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
日本血管外科学会雑誌, 24, 3, 514, 514, (NPO)日本血管外科学会, May 2015
Japanese

心臓血管 末梢吻合部位の深さからみた遠位弓部大動脈瘤に対するstaged repair選択基準の検討　　　　　　　　　　　　　　　
佐藤 公治, 若狭 哲, 浅井 英嗣, 太安 孝允, 関 達也, 内藤 祐嗣, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎
日本外科学会定期学術集会抄録集, 115回, OP, 4, (一社)日本外科学会, Apr. 2015
Japanese

Slope in preload recruitable stroke work relationship predicts survival after left ventriculoplasty and mitral repair in patients with idiopathic cardiomyopathy.
Yasushige Shingu, Suguru Kubota, Satoru Wakasa, Tomonori Ooka, Hiroki Kato, Tsuyoshi Tachibana, Yoshiro Matsui
Journal of cardiology, 65, 2, 157, 63, Feb. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Left ventriculoplasty (LVP) and mitral valve plasty (MVP) are sometimes effective for patients with idiopathic dilated cardiomyopathy (DCM) who are not eligible for heart transplantation. Strict patient selection is warranted for these controversial procedures. METHODS AND RESULTS: The subjects were 18 patients with idiopathic DCM and mitral regurgitation who had not been indicated for heart transplantation due to either older age or patient refusal, and who underwent LVP and MVP. Their mean age was 57±14 years and 50% were dependent on catecholamine infusion. The preload recruitable stroke work (PRSW) relationship and its slope (Mw) were estimated by a single-beat technique using transthoracic echocardiography. There were one 30-day mortality and six (33%) hospital deaths due to heart failure. The one-year survival rate was 50%. Left ventricular end-diastolic dimension (LVDd) decreased from 77±11 to 68±11mm (p=0.001) whereas the ejection fraction did not change. Preoperative Mw was significantly higher in one-year survivors than that in non-survivors (54±17ergcm(-3)10(3) vs. 31±10ergcm(-3)10(3), p=0.005). Preoperative LVDd was not different between the groups. The cut-off value of 42ergcm(-3)10(3) for Mw predicted one-year survival with high sensitivity (100%) and specificity (77%). CONCLUSIONS: Mw, the slope in the PRSW relationship, may predict survival after LVP and MVP in patients with idiopathic DCM.

S字状心室中隔に伴う流出路狭窄による僧帽弁逆流と弁穿孔が溶血性貧血の原因となった僧帽弁形成術後の1例　　　　　　　　　　　　　　　
横山 しのぶ, 山田 聡, 新宮 康栄, 中鉢 雅大, 岩野 弘幸, 若狭 哲, 西田 睦, 渋谷 斉, 清水 力, 松居 喜郎
超音波医学, 42, 1, 84, 84, (公社)日本超音波医学会, Jan. 2015
Japanese

Characteristics of inoperable patients with severe aortic valve stenosis -in the era of transcatheter aortic valve replacement.
Tatsuya Seki, Mamoru Sakakibara, Yasushige Shingu, Hiroki Katoh, Satoru Wakasa, Hiroyuki Tsutsui, Yoshiro Matsui
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 21, 2, 132, 8, 2015, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, PURPOSE: Transcatheter aortic valve replacement (TAVR) has emerged as a therapeutic option for severe aortic valvular stenosis (AS). To determine the indication for TAVR, it is mandatory to clarify the characteristics of the patients who were judged as inoperable for conventional aortic valve replacement (cAVR). METHODS: Of 185 patients newly diagnosed as severe AS from March 2010 to April 2011, we studied the characteristics of 61 (33%) patients (mean age, 86 ± 8 years) who were judged as inoperable. RESULTS: Younger patients (<85 years old, n = 22) had more major comorbidities and lower left ventricular ejection fraction than older patients (≥85 years old, n = 39). Mean estimated mortality for cAVR by Japan score was 7.0% ± 7.4%. Japan score did not correlate to age and was calculated relatively low in the older age group (6.2% ± 7.0%) than the younger age group (8.3% ± 8.1%). CONCLUSION: One thirds of severe AS patients were judged as inoperable. In advanced age patients, age itself and other factors, which are not included in the conventional scoring systems, might have contributed to the decision making not to perform cAVR by cardiologists. Further study is necessary to define risk factors except for age.

Surgical strategy for ischemic mitral regurgitation adopting subvalvular and ventricular procedures.
Satoru Wakasa, Yasushige Shingu, Tomonori Ooka, Hiroki Katoh, Tsuyoshi Tachibana, Yoshiro Matsui
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 21, 4, 370, 7, 2015, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, PURPOSE: The progression of left ventricular (LV) remodeling and subsequent mitral valve tethering impair the results of reduction annuloplasty for ischemic mitral regurgitation (MR). METHODS: We studied 90 patients who underwent surgical repair of ischemic MR between 1999 and 2013 according to our surgical strategy adding submitral and ventricular procedures to annuloplasty as follows: annuloplasty alone (stage 1, n = 30), additional papillary muscle approximation (PMA) for progression of tethering (stage 2, n = 26), and additional left ventriculoplasty with PMA for progression of LV remodeling and tethering (stage 3, n = 34). RESULTS: The preoperative New York Heart Association (NYHA) functional classes (2.5 ± 0.7, 3.1 ± 0.7 and 3.3 ± 0.7 for stages 1, 2 and 3, respectively, P <0.001), LV end-diastolic diameters (56 ± 7 mm, 66 ± 5 mm and 70 ± 7 mm, P <0.001), and LV ejection fractions (45 ± 12%, 32 ± 9% and 27 ± 9%, P <0.001) significantly differed among the stages. In contrast, the MR grades did not significantly differ (2.9 ± 0.8, 3.0 ± 1.0, and 2.9 ± 1.1, respectively; P = 0.93). Both the rates of cardiac-related survival and freedom from reoperation were comparable among the 3 groups (log-rank P = 0.92 and 0.58, respectively). CONCLUSION: Additional submitral and ventricular procedures can compensate for the possible impairment of the outcomes after annuloplasty alone for ischemic MR in patients with severe LV remodeling and tethering.

The extent of papillary muscle approximation affects mortality and durability of mitral valve repair for ischemic mitral regurgitation
Satoru Wakasa, Suguru Kubota, Yasushige Shingu, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui
JOURNAL OF CARDIOTHORACIC SURGERY, 9, 98, 98, Jun. 2014, [Peer-reviewed], [International Magazine]
English, Scientific journal

Internal Cuff Reimplantation Technique for Aortic Branch Reconstruction
Satoru Wakasa, Yuji Naito, Suguru Kubota, Makoto Iijima, Yasushige Shingu, Yoshiro Matsui
ANNALS OF THORACIC SURGERY, 97, 5, 1822, 1823, May 2014, [Peer-reviewed], [International Magazine]
English, Scientific journal

Histological assessment of transmurality after repeated radiofrequency ablation of the left atrial wall
Satoru Wakasa, Suguru Kubota, Yasushige Shingu, Hiroki Kato, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui
General Thoracic and Cardiovascular Surgery, 62, 7, 428, 433, Springer-Verlag Tokyo, 2014, [Peer-reviewed], [Domestic magazines]
English, Scientific journal

Echocardiography alone allows the determination of heart failure stages in rats with pressure overload
Yasushige Shingu, Paulo A. Amorim, T. Dung Nguyen, Moritz Osterholt, Michael Schwarzer, Torsten Doenst
Thoracic and Cardiovascular Surgeon, 61, 8, 718, 725, 8, Dec. 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal

Preoperative Regional Left Ventricular Wall Thickening Determined by Quantitative Gated SPECT as a Predictor of Mid-Term Surgical Results for Ischemic and Nonischemic Cardiomyopathy
Suguru Kubota, Satoru Wakasa, Yasushige Shingu, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui
CIRCULATION JOURNAL, 77, 12, 2936, 2941, Dec. 2013, [Peer-reviewed], [Domestic magazines]
English, Scientific journal

The E-Wave Deceleration Rate E/DT Outperforms the Tissue Doppler-Derived Index E/e ' in Characterizing Lung Remodeling in Heart Failure with Preserved Ejection Fraction
T. Dung Nguyen, Yasushige Shingu, Michael Schwarzer, Andrea Schrepper, Torsten Doenst
PLOS ONE, 8, 12, e82077, Dec. 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal

Glucagon-like peptide-1 reduces contractile function and fails to boost glucose utilization in normal hearts in the presence of fatty acids.
Nguyen TD, Shingu Y, Amorim PA, Schwarzer M, Doenst T
International journal of cardiology, 168, 4, 4085, 4092, 4, Oct. 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal, UNLABELLED: GLP-1 and exendin-4, which are used as insulin sensitizers or weight reducing drugs, were shown to improve glucose uptake in the heart. However, the direct effects of GLP-1 or exendin-4 on normal hearts in the presence of fatty acids, the main cardiac substrates, have never been investigated. We therefore assessed the effects of GLP-1 or exendin-4 on myocardial glucose uptake (GU), glucose oxidation (GO) and cardiac performance (CP) under conditions of fatty acid utilization. METHODS AND RESULTS: Rat hearts were perfused with only glucose (5 mM) or glucose (5 mM) plus oleate (0.4 mM) as substrates for 60 min. After 30 min, GLP-1 or exendin-4 (0.5 nM or 5 nM) was added. In the absence of oleate, GLP-1 increased both GU and GO. Exendin-4 increased GO but showed no effect on GU. Neither GLP-1 nor exendin-4 affected CP. However, when oleate was present, GLP-1 failed to stimulate glucose utilization and exendin-4 even decreased GU. Furthermore, now GLP-1 reduced CP. In contrast to prior reports, this negative inotropic effect could not be blocked by the protein kinase A inhibitor H-89. We then measured myocardial GO and CP in rats receiving a 4-week GLP-1 infusion. Interestingly, this chronic treatment resulted in a significant reduction in both GO and CP. CONCLUSIONS: Under the influence of oleate, GLP-1 reduces contractile function and fails to stimulate glucose utilization in normal hearts. Exendin-4 may acutely reduce cardiac glucose uptake but not contractility. We suggest advanced investigation of heart function and metabolism in patients treating with these peptides.

Surgical strategy for aortoesophageal fistula in the endovascular era
Suguru Kubota, Norihiko Shiiya, Yasushige Shingu, Satoru Wakasa, Tomonori Ooka, Tsuyoshi Tachibana, Hidetoshi Yamauchi, Yoshimitu Ishibashi, Jun-Ichi Oba, Yoshiro Matsui
General Thoracic and Cardiovascular Surgery, 61, 10, 560, 564, 10, 2013, [Peer-reviewed], [Domestic magazines]
English, Scientific journal

[Optimal indication for surgical ventricular restoration for dilated cardiomyopathy].
Wakasa S, Shingu Y, Kubota S, Minamida T, Iijima M, Naito Y, Ooka T, Tachibana T, Matsui Y
Kyobu geka. The Japanese journal of thoracic surgery, 66, 1, 26, 30, 1, Jan. 2013, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, In this study, we assessed mid-term results of surgical ventricular restoration (SVR) for dilated cardiomyopathy. The study subjects were 107 patients who underwent SVR for both ischemic (ischemic cardiomyopathy:ICM, n=57) and non-ischemic (dilated cardiomyopathy:DCM, n=50) dilated cardiomyopathy. In 49(86%)patients ICM was associated with New York heart Association(NYHA) class III or more. Preoperative left ventricular ejection fraction (LVEF) and left ventricular end-diastolic dimension(LVDd)were 22±6% and 67±9 mm, respectively. Hospital mortality was 14% and 5-year mortality was 40%. In contrast, 46( 92%) of the DCM patients presented with NYHA class III or more. Preoperative LVEF and LVDd were 20±6% and 74±9 mm, respectively. Hospital mortality was 28% and 5-year mortality was 63%. For NYHA class III or less, however, 5-year mortality rates were 23% and 39% in those with ICM and DCM, respectively. For those with NYHA functional class III or less, SVR was associated with a satisfactory survival rate and is recommended. For those with severe heart failure, however, ventricular assist devices or heart transplantation may have to be indicated.

Triheptanoin diet alleviates hypertrophy and diastolic dysfunction and preserves cardiac glucose oxidation in rats with pressure overload
Yasushige Shingu
European Journal of Heart Failure, 2013
Scientific journal

Postoperative atrial fibrillation: mechanism, prevention, and future perspective
Yasushige Shingu, Suguru Kubota, Satoru Wakasa, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui
SURGERY TODAY, 42, 9, 819, 824, Sep. 2012, [Peer-reviewed], [Domestic magazines]
English, Scientific journal

Did We Misunderstand How to Calculate Total Stroke Work in Mitral Regurgitation by Echocardiography?
Yasushige Shingu, Yoshiro Matsui
CIRCULATION JOURNAL, 76, 6, 1533, 1534, Jun. 2012, [Peer-reviewed], [Domestic magazines]
English, Scientific journal

The E-wave deceleration rate E/DT but not the tissue-Doppler derived index E/Ea reliably characterizes pressure-overload induced diastolic dysfunction
Yasushige Shingu
European Heart Journal, 2012
Scientific journal

[Surgical ventricular restoration for ischemic cardiomyopathy].
Wakasa S, Shingu Y, Ooka T, Tachibana T, Kubota S, Matsui Y
Kyobu geka. The Japanese journal of thoracic surgery, 64, 11, 985, 988, 11, Oct. 2011, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, In this study, we demonstrated the mid-term result of surgical ventricular restoration (SVR) for ischemic cardiomyopathy. Fifty-two patients (age 62 +/- 11 years) who underwent SVR between 2003 and 2010 were enrolled. Overlapping left ventriculoplasty, papillary muscle approximation, and coronary artery bypass grafting (CABG) were performed in 36 (69%), 39 (75%) and 46 (88%) patients, respectively. Preoperatively, 45 (87%) patients presented New York Heart Association (NYHA) class III/IV, whereas all patients presented NYHA I/III postoperatively (P < 0.01). left ventricular (LV) end-systolic volume index (LVESVI) and LV ejection fraction (LVEF) were improved postoperatively (LVESVI: 111 +/- 37 to 68 +/- 24, p < 0.01, LVEF : 30 +/- 9 to 37 +/- 11, p < 0.01). The degree of mitral regurgitation (MR) was 3+ or more in 27 (52%) patients, whereas 50 (96%) presented 1+ or less postoperatively (P < 0.01). The 1-, 3-, and 5-year survival rates were 90%. 83%, and 75%, respectively. Cox regression analysis demonstrated that preoperative MR 4+ was the significant predictor of postoperative death (P < 0.05, HR 5.2, 95% CI 1.2-22.9). Because of its satisfactory mid-term result, SVR would be validated as an effective procedure for ischemic cardiomyopathy.

Left-ventricular electromechanical delay is prolonged in patients with postoperative atrial fibrillation
Yasushige Shingu, Suguru Kubota, Satoru Wakasa, Noriyoshi Ebuoka, Daisuke Mori, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 39, 5, 684, 688, May 2011, [Peer-reviewed], [International Magazine]
English, Scientific journal

Oleate controls the effects of GLP-1 and exendin-4 on myocardial glucose utilization and contractile function
Yasushige Shingu
European Heart Journal, 2011
Scientific journal

Chronic GLP-1 treatment preserves diastolic function and improves survival in rats with pressure overload
Yasushige Shingu
European Heart Journal, 2011
Scientific journal

Chronic GLP-1 treatment preserves diastolic function and improves survival in rats with pressure overload
Yasushige Shingu
American Journal of Respiratory and Critical Care Medicine, 2011
Scientific journal

Myocardial performance (Tei) index is normal in diastolic and systolic heart failure induced by pressure overload in rats
Yasushige Shingu, Paulo Amorim, T. Dung Nguyen, Friedrich W. Mohr, Michael Schwarzer, Torsten Doenst
EUROPEAN JOURNAL OF ECHOCARDIOGRAPHY, 11, 10, 829, 833, Dec. 2010, [Peer-reviewed], [International Magazine]
English, Scientific journal

Myocardial infarction in rats causes partial impairment in insulin response associated with reduced fatty acid oxidation and mitochondrial gene expression
Paulo A. Amorim, T. Dung Nguyen, Yasushige Shingu, Michael Schwarzer, Friedrich W. Mohr, Andrea Schrepper, Torsten Doenst
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 140, 5, 1160, 1167, Nov. 2010, [Peer-reviewed], [International Magazine]
English, Scientific journal

HOW CAN WE PREVENT FUNCTIONAL MITRAL STENOSIS AFTER SURGERY?
Yasushige Shingu, Yoshiro Matsui
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 140, 1, 251, 252, Jul. 2010, [Peer-reviewed], [International Magazine]
English

Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload
Torsten Doenst, Gracjan Pytel, Andrea Schrepper, Paulo Amorim, Gloria Faerber, Yasushige Shingu, Friedrich W. Mohr, Michael Schwarzer
CARDIOVASCULAR RESEARCH, 86, 3, 461, 470, Jun. 2010, [Peer-reviewed], [International Magazine]
English, Scientific journal

A Presumed Mechanism of Mitral Regurgitation after Left Ventriculoplasty
Yasushige Shingu, Takashi Sugiki, Tomonori Ooka, Tsuyoshi Tachibana, Suguru Kubota, Yoshiro Matsui
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, 16, 2, 139, 141, Apr. 2010, [Peer-reviewed], [Domestic magazines]
English, Scientific journal

Myocardial performance (Tei) index is normal in diastolic and systolic heart failure induced by pressure overload in rats
Yasushige Shingu
European Journal of Echocardiography, 2010
Scientific journal

Papillary Muscle Suspension Concomitant With Approximation for Functional Mitral Regurgitation
Yasushige Shingu, Satoshi Yamada, Tomonori Ooka, Tsuyoshi Tachibana, Suguru Kubota, Hiroyuki Tsutsui, Yoshiro Matsui
CIRCULATION JOURNAL, 73, 11, 2061, 2067, Nov. 2009, [Peer-reviewed], [Domestic magazines]
English, Scientific journal

Anatomical Pattern of Feeding Artery and Mechanism of Intraoperative Spinal Cord Ischemia
Norihiko Shiiya, Satoru Wakasa, Kinya Matsui, Takashi Sugiki, Yasushige Shingu, Tomoshi Yamakawa, Yoshiro Matsui
ANNALS OF THORACIC SURGERY, 88, 3, 768, 772, Sep. 2009, [Peer-reviewed], [International Magazine]
English, Scientific journal

成人重複大動脈弓の1例
阿部 慎司, 夷岡 徳彦, 新宮 康栄, 杉木 孝司, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 山川 智士, 椎谷 紀彦, 村下 十志文, 松居 喜郎
日本小児循環器学会雑誌, 25, 4, 638, 639, (NPO)日本小児循環器学会, Jul. 2009
Japanese

心臓腫瘍との鑑別に苦慮した冠動脈仮性瘤の1例　　　　　　　　　　　　　　　
太安 孝允, 加藤 伸康, 佐藤 公治, 夷岡 徳彦, 新宮 康栄, 杉木 孝司, 松井 欣哉, 若狭 哲, 大岡 智学, 橘 剛, 山川 智士, 久保田 卓, 椎谷 紀彦, 松居 喜郎, 大山 徳子, 筒井 裕之
北海道外科雑誌, 54, 1, 69, 70, 北海道外科学会, Jun. 2009
Japanese

Augmentation Index Is Elevated in Aortic Aneurysm and Dissection
Yasushige Shingu, Norihiko Shiiya, Tomonori Ooka, Tsuyoshi Tachibana, Suguru Kubota, Satoshi Morita, Yoshiro Matsui
ANNALS OF THORACIC SURGERY, 87, 5, 1373, 1378, May 2009, [Peer-reviewed], [International Magazine]
English, Scientific journal

Histopathological study of specimens obtained by left ventricular biopsy during ventriculoplasty for idiopathic dilated cardiomyopathy
Shinichiro Shimura, Yoshiro Matsui, Chikao Yutani, Yukio Suto, Okihiko Akashi, Kinya Matsui, Yasushige Shingu, Mamoru Sakakibara, Masaomi Yamaguchi, Yasuo Haruki, Kou Takigami, Takashi Minase, Toshihiko Ueda
Tokai Journal of Experimental and Clinical Medicine, 34, 1, 1, 7, 1, 2009, [Peer-reviewed], [Domestic magazines]
English, Scientific journal

Sivelestat Sodium is Effective to Prevent Acute Lung Injury in Acute Aortic Dissection
Yasushige Shingu, Norihiko Shiiya, Suguru Kubota, Yuji Naito, Kinya Matsui, Satoru Wakasa, Hiroshi Sugiki, Tsuyoshi Tachibana, Tomoji Yamakawa, Toshifumi Murashita, Yoshiro Matsui
ADVANCES IN UNDERSTANDING AORTIC DISEASES, 187, 187, 2009, [Peer-reviewed]
English, International conference proceedings

術後22年目に弁機能不全により再弁置換を行った僧帽弁位牛心膜生体弁の一例　　　　　　　　　　　　　　　
久保田 卓, 松居 喜郎, 佐藤 公治, 夷岡 徳彦, 新宮 康栄, 杉木 孝司, 若狭 哲, 大岡 智学, 橘 剛, 山川 智士, 椎谷 紀彦
人工臓器, 37, 2, S, 111, (一社)日本人工臓器学会, Nov. 2008
Japanese

[Effect of sivelestat sodium on acute lung injury after acute aortic dissection].
Shingu Y, Shiiya N, Matsuzaki K, Kunihara T, Murashita T, Matsui Y
Kyobu geka. The Japanese journal of thoracic surgery, 61, 6, 440, 443, 6, Jun. 2008, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, Acute lung injury is a frequent and serious complication in patients with acute aortic dissection (AAD). Elevated neutrophil elastase has been reported to be one of the major determinants occurring in AAD. On admission, we administered sivelestat sodium hydrate, a neutrophil elastase inhibitor, to 11 patients with AAD who were medically treated to prevent lung injury. We compared their clinical course with that of 12 patients of control group in which sivelestat was not used prophylacticaly. Although there were 5 patients (42%) who suffered from respiratory failure and needed mechanical ventilation in the control group, no one needed intubation in the sivelestat group. Our study suggested that sivelestat sodium hydrate could be effective in preventing intubation due to respiratory failure. Further prospective study is necessary to evaluate prophylactic administration of sivelestat sodium hydrate in AAD.

胸骨裏食道再建後の大動脈弁閉鎖不全症(AR)に対する左開胸での大動脈弁置換術の1例
若狭 哲, 阿部 慎司, 夷岡 徳彦, 内藤 祐嗣, 新宮 康栄, 松井 欣哉, 杉木 孝司, 大岡 智学, 橘 剛, 久保田 卓, 山川 智士, 椎谷 紀彦, 村下 十志文, 松居 喜郎
北海道外科雑誌, 53, 1, 116, 116, 北海道外科学会, Jun. 2008
Japanese

Microembolization from an Abdominal Aortic Aneurysm after Thoracic Aortic Replacement
Yasushige Shingu, Norihiko Shiiya, Takashi Sugiki, Satoru Wakasa, Kenji Matsuzaki, Takashi Kunihara, Yoshiro Matsui
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, 14, 2, 126, 128, Apr. 2008, [Peer-reviewed], [Domestic magazines]
English, Scientific journal

遠隔期に再手術を要した人工弁周囲逆流症(PVL)の2例
夷岡 徳彦, 阿部 慎司, 内藤 祐嗣, 新宮 康栄, 松井 欣哉, 杉木 孝司, 若狭 哲, 杉木 宏司, 橘 剛, 久保田 卓, 山川 智士, 椎谷 紀彦, 村下 十志文, 松居 喜郎
北海道外科雑誌, 52, 2, 209, 209, 北海道外科学会, Dec. 2007
Japanese

Juxtarenal AAA手術症例の検討
内藤 祐嗣, 阿部 慎司, 夷岡 徳彦, 新宮 康栄, 杉木 孝司, 松井 欣哉, 若狭 哲, 杉木 宏司, 橘 剛, 山川 智士, 久保田 卓, 椎谷 紀彦, 村下 十志文, 松居 喜郎
北海道外科雑誌, 52, 2, 212, 212, 北海道外科学会, Dec. 2007
Japanese

虚血性MRの病態と治療戦略 拡大心によるfunctional MRに対して僧帽弁輪形成にPapillary muscle approximationを加えた治療戦略　　　　　　　　　　　　　　　
久保田 卓, 松居 喜郎, 阿部 慎司, 夷岡 徳彦, 新宮 康栄, 杉木 孝司, 若狭 哲, 橘 剛, 山川 智士, 椎谷 紀彦, 村下 十志文
日本冠疾患学会雑誌, 13, 4, 296, 296, (NPO)日本冠疾患学会, Nov. 2007
Japanese

開心術後のCEDV/RVEFモニタリングによる右室容量と中心静脈圧の変化　　　　　　　　　　　　　　　
新宮 康栄, 松井 欣哉, 杉木 孝司, 若狭 哲, 杉木 宏司, 橘 剛, 山川 智士, 久保田 卓, 椎谷 紀彦, 村下 十志文, 松居 喜郎
日本臨床外科学会雑誌, 68, 9, 2420, 2420, 日本臨床外科学会, Sep. 2007
Japanese

シャント閉鎖術後、自家静脈再建術後、再々発上腕動脈瘤の一例　　　　　　　　　　　　　　　
松井 欣哉, 椎谷 紀彦, 新宮 康栄, 杉木 孝, 若狭 哲, 杉木 宏司, 橘 剛, 山川 智士, 久保田 卓, 村下 十志文, 松居 喜郎
日本臨床外科学会雑誌, 68, 9, 2421, 2421, 日本臨床外科学会, Sep. 2007
Japanese

上行弓部大動脈置換術後における急性期心機能と脳性ナトリウム利尿ペプチド(BNP)　　　　　　　　　　　　　　　
新宮 康栄, 椎谷 紀彦, 阿部 慎司, 内藤 祐嗣, 松井 欣哉, 若狭 哲, 杉木 宏司, 橘 剛, 山川 智士, 久保田 卓, 村下 十志文, 松居 喜郎
脈管学, 47, Suppl., S128, S128, (一社)日本脈管学会, Sep. 2007
Japanese

心不全、不整脈に対する外科治療 重症心不全に対する左室形成術のpitfalls　　　　　　　　　　　　　　　
松居 喜郎, 杉木 宏司, 若狭 哲, 新宮 康栄, 久保田 卓, 椎谷 紀彦, 村下 十志文
日本外科系連合学会誌, 32, 3, 495, 495, 日本外科系連合学会, Jun. 2007
Japanese

適応の破綻と修復 重症心不全に対する左室形成術による外科治療
松居 喜郎, 新宮 康栄, 若狭 哲, 杉木 宏司, 杉木 孝司, 松井 欣哉, 椎谷 紀彦, 村下 十志文
適応医学, 11, 1, 21, 21, 日本適応医学会, May 2007
Japanese

Left ventricular diastolic dysfunction in chronic aortic dissection
Yasushige Shingu, Norihiko Shiiya, Taisei Mikami, Kenji Matsuzaki, Takashi Kunihara, Yoshiro Matsui
ANNALS OF THORACIC SURGERY, 83, 4, 1356, 1360, Apr. 2007, [Peer-reviewed], [International Magazine]
English, Scientific journal

Dysphagia due to aortic diverticulum: an adult surgical case.
Shingu Y, Shiiya N, Matsuzaki K, Kunihara T, Matsui Y
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 13, 2, 132, 134, 2, Apr. 2007, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, A right aortic arch is an anatomic variant only occurring in approximately 0.1% of the population. A mirror-image right artic arch without congenital cardiac anomaly is fairly uncommon. We report on a rare case of dysphagia due to isolated aortic diverticulum in a mirror-image right aortic arch. A 72-year-old man presented with dysphagia which was due to posterior compression of the esophagus by a dilated aortic diverticulum. There was no vascular ring and we thought that the pathology was atherosclerotic dilatation of the diverticulum. Graft replacement of the diverticulum was sufficient to relieve his symptom.

IMRを伴ったICMに対するdouble orifice techniqueと左室形成術の治療経験　　　　　　　　　　　　　　　
杉木 孝司, 村下 十志文, 国原 孝, 杉木 宏司, 新宮 康栄, 松崎 賢司, 窪田 武浩, 椎谷 紀彦
The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 54, 5, 29, 29, (一社)日本胸部外科学会, May 2006
Japanese

外傷性末梢動脈疾患に対する手術の経験
若狭 哲, 新宮 康栄, 杉木 宏司, 菅 敏郎, 松崎 賢司, 國原 孝, 上久保 康弘, 椎谷 紀彦
北海道外科雑誌, 50, 2, 177, 177, 北海道外科学会, Dec. 2005
Japanese

A surgical case for hemolytic anemia after ascending and total arch replacement.
Shingu Y, Aoki H, Ebuoka N, Eya K, Takigami K, Oba J, Chiba K, Fukuhara T
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 11, 6, 416, 418, 6, Dec. 2005, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, A 61-year-old man presented with consistent hemolytic anemia 15 months after ascending and total arch replacement for DeBakey I type acute aortic dissection. The cause of hemolysis turned out to be mechanical damage of red blood cells at the inverted felt of the proximal anastomosis. Reoperation of resection of the felt and repair of the proximal anastomosis successfully resolved this problem. We report a rare case of hemolytic anemia at the site of inverted felt strip after total arch replacement.

Late rupture of knitted Dacron graft.
Shingu Y, Aoki H, Ebuoka N, Eya K, Takigami K, Oba J
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 11, 5, 343, 345, 5, Oct. 2005, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, An 87-year-old man underwent aorto-bifemoral bypass using a bifurcated Bionit II knitted Dacron graft for high aortic occlusion in 1987 at another hospital. In November, 2004, he was admitted to our institution because of difficulty in walking due to swelling and tenderness in the right groin. Computed tomography (CT) scan indicated bilateral aneurysms of the grafts in the groins. The size of the right and left aneurysms were 73 mm and 52 mm, respectively. Angiography showed some extravasation in the right thigh. We performed surgical replacement of all the dilated parts with new ringed-Dacron grafts. We report a rare case of late rupture of bifurcated Sauvage Bionit II Dacron graft.

[Operative decision for acute type A aortic dissection; ascending aorta or arch replacement].
Shingu Y, Aoki H, Oba J, Takigami K, Eya K, Ebuoka N
Kyobu geka. The Japanese journal of thoracic surgery, 58, 7, 565, 568, 7, Jul. 2005, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, Operative technique of acute type A aortic dissection remains controversial. We adopted the strategy to replace the aortic arch only when the entry of the dissection was found in the aortic arch, or atherosclerotic arch aneurysm existed. The purpose of the current study was to elucidate the feasibility of the ascending aorta and hemiarch replacement and to follow the fate of the patent false lumen distal to the anastomosis after surgery. Nineteen patients operated from 2000 to 2004 were included in this study. Ascending or hemiarch replacement were performed in 15/19 (78.9%) patients. The early mortality rate was 10.5% (2/19). The causes of death included major brain infarction and rupture of the descending aortic aneurysm 25 +/- 23 days after surgery. Thrombosed distal false lumen of the thoracic aorta was observed in 60% (9/15) of patients of De Bakey type I dissection. Thus our strategy for acute type A aortic dissection including entry closure and the ascending or hemiarch replacement is a reasonable option especially for the elderly patients in acute phase. Our results also indicated that the thrombosis of the false lumen distal to the anastomosis can be expected and the enlargement of the distal aorta is minimal.

A surgical case for severe hemolytic anemia after mitral valve repair.
Shingu Y, Aoki H, Ebuoka N, Eya K, Takigami K, Oba J, Fukuhara T
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 11, 3, 198, 200, 3, Jun. 2005, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, We report a rare case of severe hemolytic anemia accompanied by moderate renal insufficiency after mitral valve repair. Although the degree of the residual mitral regurgitation was less than 1+ during the first three weeks after the operation, the maximum lactate dehydrogenase (LDH) was up to 7,430 U/l and the minimum hemoglobin was 4.9 g/dl. The mitral valve replacement successfully resolved the hemolysis, but the renal function did not completely recover.

Surgical treatment of ventricular and pericardial perforation by a permanent pacing lead: A case report
Junichi Oba, Hidetoshi Aoki, Ko Takigami, Kazuhiro Eya, Suguru Kubota, Yasushige Shingu
Journal of Cardiology, 45, 2, 69, 73, 2, Feb. 2005, [Peer-reviewed], [International Magazine]
Japanese, Scientific journal

Real-Time Cerebral Monitoring Using Multichannel Near-Infrared Spectroscopy in Total Arch Replacement
Yasushige Shingu, Kazuhiro Myojin, Yoshimitsu Ishibashi, Kouji Ishii, Masakazu Kawasaki, Genbu Yamaura
Japanese Journal of Thoracic and Cardiovascular Surgery, 51, 4, 154, 157, Japanese Association for Thoracic Surgery, 2003, [Peer-reviewed], [Domestic magazines]
English, International conference proceedings

Is Conservative Therapy Acceptable for Thrombosed Type A Acute Aortic Dissection?
Yasushige Shingu, Kazuhiro Myojin, Yoshimitsu Ishibashi, Koji Ishii, Masakazu Kawasaki, Keitaro Ijima
Japanese Journal of Thoracic and Cardiovascular Surgery, 51, 10, 496, 499, Japanese Association for Thoracic Surgery, 2003, [Peer-reviewed], [Domestic magazines]
English, International conference proceedings

Treatment of Mitral Valve Infective Endocarditis in a Patient with Severe Metal Allergy: A Case Report
松井双葉, 齊藤慈円, 加藤伸康, 阿部慎司, 加藤裕貴, 大岡智学, 新宮康栄, 若狭哲, 北海道外科雑誌, 69, 1, 2024

特集 ファロー四徴症に対する外科治療 : 新生児期・幼少期から成人期まで—Surgery for tetralogy of Fallot from infancy to adulthood
加藤 伸康, 阿部 慎司, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲, 北海道外科雑誌 = The Hokkaido journal of surgery / 北海道外科雑誌編集委員会 編, 67, 1, 2, 9, Jun. 2022
Japanese

VISUALIZATION OF PERIPROCEDUAL BLOOD FLOW DYNAMICS WITH FOUR-DIMENSIONAL FLOW MAGNETIC RESONANCE IMAGING IN PATIENTS WITH SEVERE AORTIC STENOSIS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT
Hirokazu Komoriyama, Kiwamu Kamiya, Toshiyuki Nagai, Noriko Oyama-Manabe, Satonori Tsuneta, Yuta Kobayashi, Yoshiya Kato, Kazunori Omote, Takao Konishi, Takuma Sato, Shingo Tsujinaga, Hiroyuki Iwano, Yasushige Shingu, Satoru Wakasa, Toshihisa Anzai, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 75, 11, 1639, 1639, Mar. 2020
English, Summary international conference

胸腹部大動脈瘤手術時の肋間動脈再建法の工夫と脊髄保護-internal cuff reimplantation法の有用性
佐藤公治, 杉本聡, 加藤伸康, 新宮康栄, 杉木宏司, 加藤裕貴, 大岡智学, 若狭哲, 日本胸部外科学会定期学術集会(Web), 73rd, 2020

Midterm results of stent graft-conserving aneurysmorrhaphy
佐藤公治, 若狭哲, 新宮康栄, 杉木宏司, 加藤裕貴, 大岡智学, 日本血管外科学会雑誌(Web), 29, Supplement, 2020

川崎病冠動脈障害に対する冠動脈バイパス術　　　　　　　　　　　　　　　
安東 悟央, 若狭 哲, 加藤 伸康, 新宮 康栄, 加藤 裕貴, 大岡 智学, 日本冠疾患学会誌, Suppl.2019, 179, 179, Dec. 2019
(NPO)日本冠疾患学会, Japanese

肉眼的に乳頭状線維弾性腫と鑑別が困難であったvilloustype左房粘液腫の1例　　　　　　　　　　　　　　　
石垣 隆弘, 新宮 康栄, 加藤 伸康, 若狭 哲, 大岡 智学, 加藤 裕貴, 若林 健人, 三橋 智子, 松居 喜郎, 北海道外科雑誌, 64, 2, 207, 207, Dec. 2019
北海道外科学会, Japanese

カルニチンによる心臓弁膜症手術後の心房細動の予防(単群介入試験)　　　　　　　　　　　　　　　
新宮 康栄, 小市 裕太, 稗田 哲也, 新井 洋輔, 安東 悟央, 石垣 隆弘, 佐藤 公治, 加藤 伸康, 若狭 哲, 大岡 智学, 北海道外科雑誌, 64, 2, 209, 209, Dec. 2019
北海道外科学会, Japanese

肉眼的に乳頭状線維弾性腫と鑑別が困難であったvillous type左房粘液腫の1例
石垣 隆弘, 新宮 康栄, 加藤 伸康, 若狭 哲, 大岡 智学, 加藤 裕貴, 松居 喜郎, 日本心臓血管外科学会雑誌, 48, 6, 405, 410, Nov. 2019
(NPO)日本心臓血管外科学会, Japanese

感染性大動脈瘤に対するウシ心膜ロールを用いた人工血管置換症例の検討　　　　　　　　　　　　　　　
関 達也, 松居 喜郎, 新宮 康栄, 大岡 智学, 若狭 哲, 脈管学, 59, Suppl., S231, S231, Oct. 2019
(一社)日本脈管学会, Japanese

原発性肺動脈腫瘍に対する治療経験　　　　　　　　　　　　　　　
安東 悟央, 大岡 智学, 小市 裕太, 新井 洋輔, 稗田 哲也, 石垣 隆弘, 佐藤 公治, 関 達也, 新宮 康栄, 若狭 哲, 加藤 裕貴, 脈管学, 59, Suppl., S288, S288, Oct. 2019
(一社)日本脈管学会, Japanese

長期(3年以上)VAD治療の課題と対策 長期植込型補助人工心臓治療の現状、課題、そして対策　　　　　　　　　　　　　　　
大岡 智学, 加藤 伸康, 新宮 康栄, 若狭 哲, 加藤 裕貴, 松居 喜朗, 寒河江 磨, 矢萩 亮児, 櫛引 勝年, 加藤 美香, 人工臓器, 48, 2, S, 75, Oct. 2019
(一社)日本人工臓器学会, Japanese

重症心不全に対する左室介入手術の功罪
松居喜郎, 新宮康栄, 若狭哲, 久保田卓, 大岡智学, 加藤信康, 加藤裕貴, 日本心臓血管外科学会学術総会(Web), 49回, [Ex, 3], Feb. 2019
(NPO)日本心臓血管外科学会, Japanese

補助循環・外科療法 左室形成術・僧帽弁関連手術
松居喜郎, 新宮康栄, 若狭哲, 大岡智学, 久保田卓, 日本臨床, 77, 増刊1 心不全(中), 446, 451, Feb. 2019
(株)日本臨床社, Japanese

Ligation of Lumbar Arteries and Stent Graft‐Conserving Aneurysmorrhaphy for Type II Endoleak
佐藤公治, 新宮康栄, 若狭哲, 加藤伸康, 関達也, 大岡智学, 加藤裕貴, 橘剛, 久保田卓, 松居喜郎, 日本心臓血管外科学会雑誌, 47, 6, 257, 262, Nov. 2018
(NPO)日本心臓血管外科学会, Japanese

成人期に診断された右冠動脈肺動脈起始症の1治験例　　　　　　　　　　　　　　　
安東 悟央, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 久保田 卓, 松居 喜郎, 日本心臓血管外科学会雑誌, 47, 5, 215, 219, Sep. 2018
(NPO)日本心臓血管外科学会, Japanese

【重症心不全に対する最新の外科治療】 重症非虚血性拡張型心筋症に対する外科治療選択　　　　　　　　　　　　　　　
新宮 康栄, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 胸部外科, 71, 7, 484, 487, Jul. 2018
(株)南江堂, Japanese

孤立性高度三尖弁逆流の実態調査　　　　　　　　　　　　　　　
岩野 弘幸, 山田 聡, 新宮 康栄, 更科 美羽, 辻永 真吾, 林 大知, 松居 喜郎, 安斉 俊久, 超音波医学, 45, Suppl., S616, S616, Apr. 2018
(公社)日本超音波医学会, Japanese

肺動脈閉鎖症兼心室中隔欠損症に対するWaterston手術40年後の巨大肺動脈瘤に対する1治験例
安東 悟央, 橘 剛, 加藤 伸康, 有村 聡士, 浅井 英嗣, 新宮 康栄, 若狭 哲, 加藤 裕貴, 大岡 智学, 松居 喜郎, 日本心臓血管外科学会雑誌, 47, 1, 13, 17, Jan. 2018
(NPO)日本心臓血管外科学会, Japanese

Coronary Artery Stenosis is Associated With Mitochondrial Dysfunction in Epicardial Adipose Tissue
Takayuki Nakajima, Takashi Yokota, Yasushige Shingu, Akira Yamada, Yutaka Iba, Kosuke Ujihara, Shuhei Miura, Shingo Takada, Ryosuke Shirakawa, Takaaki Furihata, Masaya Tsuda, Junichi Matsumoto, Takashi Katayama, Arata Fukushima, Akimichi Saito, Yoshiro Matsui, Shintaro Kinugawa, CIRCULATION, 136, Nov. 2017
English, Summary international conference

人工血管内血栓による消費性凝固障害に対してダビガトランが奏功した1例　　　　　　　　　　　　　　　
村瀬 亮太, 新宮 康栄, 家子 正裕, 大岡 智学, 橘 剛, 松居 喜郎, 脈管学, 57, Suppl., S201, S201, Oct. 2017
(一社)日本脈管学会, Japanese

胸郭出口症候群に対する治療経験　　　　　　　　　　　　　　　
安東 悟央, 新宮 康栄, 石垣 隆弘, 村瀬 亮太, 杉本 聡, 関 達也, 加藤 伸康, 浅井 英嗣, 太安 孝允, 加藤 裕貴, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 脈管学, 57, Suppl., S228, S229, Oct. 2017
(一社)日本脈管学会, Japanese

慢性A型大動脈解離により大動脈弁上真腔狭窄を来した1例　　　　　　　　　　　　　　　
石垣 隆弘, 新宮 康栄, 加藤 裕貴, 大岡 智学, 久保田 卓, 橘 剛, 松居 喜郎, 脈管学, 57, Suppl., S265, S265, Oct. 2017
(一社)日本脈管学会, Japanese

ブタ心を用いた熱可塑性人工弁輪の変形にともなう僧帽弁接合様式の検討　　　　　　　　　　　　　　　
関 達也, 新宮 康栄, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 人工臓器, 46, 2, S, 101, Aug. 2017
(一社)日本人工臓器学会, Japanese

植込み型VADの進歩と装着・管理の秘訣 Cカーブ+ドライブライン貫通部大網充填は、Heartmate II装着後のドライブライン感染を減らせるか?　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 加藤 裕貴, 橘 剛, 久保田 卓, 櫛引 勝年, 加藤 美香, 寒河江 磨, 矢萩 亮児, 松居 喜郎, 人工臓器, 46, 2, S, 48, Aug. 2017
(一社)日本人工臓器学会, Japanese

大血管転位症3型に対する当院の治療戦略 体肺動脈短絡術+短周径肺動脈絞扼術(BT-shunt with tight PAB)の有効性　　　　　　　　　　　　　　　
加藤 伸康, 橘 剛, 佐々木 理, 泉 岳, 山澤 弘州, 武田 充人, 新宮 康栄, 若狭 哲, 加藤 裕貴, 大岡 智学, 松居 喜郎, 日本小児循環器学会雑誌, 33, Suppl.1, s1, 224, Jul. 2017
(NPO)日本小児循環器学会, Japanese

人工血管を用いたバイパス術により軽快したabdominal anginaの1例
古川夕里香, 安東悟央, 村瀬亮太, 杉本聡, 佐藤公治, 加藤伸康, 新宮康栄, 加藤裕貴, 若狭哲, 大岡智学, 橘剛, 松居喜郎, 北海道外科雑誌, 62, 1, 80, 20 Jun. 2017
Japanese

TypeIIエンドリークに対するステントグラフト温存直達手術　　　　　　　　　　　　　　　
佐藤 公治, 新宮 康栄, 太安 孝允, 加藤 伸康, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本血管外科学会雑誌, 26, Suppl., V4, 10, Jun. 2017
(NPO)日本血管外科学会, Japanese

Frailtyからみた腹部大動脈瘤開腹手術の成績　　　　　　　　　　　　　　　
村瀬 亮太, 新宮 康栄, 大岡 智学, 若狭 哲, 橘 剛, 松居 喜郎, 日本血管外科学会雑誌, 26, Suppl., O18, 3, Jun. 2017
(NPO)日本血管外科学会, Japanese

胸腹部動脈瘤術後脊髄障害予防を目的とした分節動脈再建法の工夫 再建動脈開存性の意義　　　　　　　　　　　　　　　
若狭 哲, 佐藤 公治, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本血管外科学会雑誌, 26, Suppl., P19, 8, Jun. 2017
(NPO)日本血管外科学会, Japanese

右冠動脈肺動脈起始症に対しreimplantation法、肺動脈欠損壁自己心膜パッチ形成術を施行した1例　　　　　　　　　　　　　　　
安東 悟央, 大岡 智学, 古川 夕里香, 村瀬 亮太, 杉本 聡, 佐藤 公治, 加藤 伸康, 浅井 英嗣, 太安 孝允, 新宮 康栄, 若狭 哲, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本血管外科学会雑誌, 26, Suppl., P37, 8, Jun. 2017
(NPO)日本血管外科学会, Japanese

冠動脈肺動脈起始症(ACAPA)と冠動脈肺動脈瘻の治療経験
安東 悟央, 大岡 智学, 古川 夕里香, 有村 聡士, 村瀬 亮太, 杉本 聡, 佐藤 公治, 加藤 伸康, 新宮 康栄, 若狭 哲, 橘 剛, 松居 喜郎, 太安 孝允, 加藤 裕貴, 北海道外科雑誌, 62, 1, 80, 80, Jun. 2017
北海道外科学会, Japanese

急性期にタクロリムスが原因とされる横紋筋融解症・多臓器不全を呈した心移植の1例　　　　　　　　　　　　　　　
大岡 智学, 大安 孝允, 新宮 康栄, 若狭 哲, 加藤 裕貴, 橘 剛, 松居 喜郎, 小林 真梨子, 櫛引 勝年, 移植, 52, 1, 90, 91, Apr. 2017
(一社)日本移植学会, Japanese

我が国の人工心臓治療の現況と展望 Destination Therapy導入に向け、5年間の植込型補助人工心臓によるBridge to Transplantationから何を学んだか?　　　　　　　　　　　　　　　
大岡 智学, 佐藤 公治, 新宮 康栄, 加藤 裕貴, 若狭 哲, 橘 剛, 松居 喜郎, 日本外科学会定期学術集会抄録集, 117回, SY, 5, Apr. 2017
(一社)日本外科学会, English

Mitochondrial Dysfunction in Epicardial Adipose Tissue is Associated with Coronary Artery Stenosis(和訳中)
中島 孝之, 横田 卓, 新宮 康栄, 山田 陽, 伊庭 裕, 若狭 哲, 大岡 智学, 高田 真吾, 白川 亮介, 降旗 高明, 津田 正哉, 松本 純一, 片山 貴史, 福島 新, 松居 喜郎, 絹川 真太郎, 日本循環器学会学術集会抄録集, 81回, PJ, 075, Mar. 2017
(一社)日本循環器学会, English

左室流出路狭窄を伴う有症候性の高度大動脈弁狭窄症に対してTAVIを施行した1例
加藤喜哉, 浅川直也, 表和徳, 徳田裕輔, 岩野弘幸, 山田聡, 森敏洋, 新宮康栄, 久保田卓, 松居喜郎, 安斉俊久, 日本循環器学会北海道地方会(Web), 118th, 2017

植込み型補助人工心臓装着患者の在宅管理 北海道大学病院における植込型補助人工心臓装着患者に対する在宅管理の現状と課題　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 櫛引 勝年, 加藤 美香, 鴇田 智久, 矢萩 亮児, 寒河江 磨, 松居 喜郎, 人工臓器, 45, 2, S, 57, Oct. 2016
(一社)日本人工臓器学会, Japanese

Patients Selection for Left Ventriculoplasty and Mitral Valve Surgery in Non-Ischemic Dilated Cardiomyopathy
Yasushige Shingu, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui, JOURNAL OF CARDIAC FAILURE, 22, 9, S155, S155, Sep. 2016
English, Summary international conference

先天性左総頸動脈・気管支動脈-肺動脈瘻と左右両冠動脈-肺動脈瘻合併症例の手術経験
窪田 武浩, 若狭 哲, 新宮 康栄, 松居 喜郎, 日本心臓血管外科学会雑誌, 45, 4, 170, 175, Jul. 2016
(NPO)日本心臓血管外科学会, Japanese

TEVAR後のtypeIIエンドリークによる瘤拡大に対して動脈瘤直接切開による肋間動脈結紮および瘤縫縮を施行した1例　　　　　　　　　　　　　　　
村瀬 亮太, 若狭 哲, 杉本 聡, 佐藤 公治, 浅井 英嗣, 太安 孝允, 小林 一哉, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本血管外科学会雑誌, 25, Suppl., 228, 228, Jun. 2016
(NPO)日本血管外科学会, Japanese

感染性大動脈瘤手術における遠隔期再感染予防　　　　　　　　　　　　　　　
飯島 誠, 若狭 哲, 新宮 康栄, 加藤 裕貴, 大岡 智学, 橘 剛, 松居 喜郎, 日本血管外科学会雑誌, 25, Suppl., 251, 251, Jun. 2016
(NPO)日本血管外科学会, Japanese

鼠径部の人工血管感染に対して閉鎖孔バイパス術を施行した3例の経験　　　　　　　　　　　　　　　
須野 賢一郎, 新宮 康栄, 杉本 聡, 村瀬 亮太, 浅井 英嗣, 大安 孝允, 佐藤 公治, 飯島 誠, 小林 一哉, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本血管外科学会雑誌, 25, Suppl., 362, 362, Jun. 2016
(NPO)日本血管外科学会, Japanese

Unicuspid Aortic Valve Stenosis Combined with Aortic Coarctation : Report of a Case
窪田 武浩, 若狭 哲, 新宮 康栄, 松居 喜郎, 胸部外科, 69, 6, 467, 470, Jun. 2016
(株)南江堂, Japanese

突然死を来たす疾患の病態と治療　　　　　　　　　　　　　　　
澤村 淳, 方波見 謙一, 石森 直樹, 新宮 康栄, 中山 若樹, 北海道医学雑誌, 91, 1, 27, 30, May 2016
北海道医学会, Japanese

【心臓弁膜症:治療の最前線、未来への展望】 心臓弁膜症治療の最前線 外科医vs.内科医それぞれの立場から 感染性心内膜炎編 感染性心内膜炎に対する外科手術　　　　　　　　　　　　　　　
松居 喜郎, 若狭 哲, 大岡 智学, 新宮 康栄, 日本内科学会雑誌, 105, 2, 238, 244, Feb. 2016
(一社)日本内科学会, Japanese

Surgical Strategy for Ischemic Mitral Regurgitation Adopting Subvalvular and Ventricular Procedures (vol 21, pg 370, 2015)
Satoru Wakasa, Yasushige Shingu, Tomonori Ooka, Hiroki Katoh, Tsuyoshi Tachibana, Yoshiro Matsui, ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, 22, 2, 125, 125, 2016
English, Others

小児先天性心疾患術後管理におけるトルバプタンの使用経験　　　　　　　　　　　　　　　
太安 孝允, 浅井 英嗣, 佐藤 公治, 新宮 康栄, 加藤 裕貴, 大岡 智学, 若狭 哲, 橘 剛, 松居 喜郎, 丸藤 哲, 日本集中治療医学会雑誌, 23, Suppl., 514, 514, Jan. 2016
(一社)日本集中治療医学会, Japanese

機能的単心室における無機能右室に対する右室内腔縫縮術の応用
浅井 英嗣, 橘 剛, 新宮 康栄, 若狭 哲, 大岡 智学, 松居 喜郎, 日本心臓血管外科学会雑誌, 45, 1, 26, 31, Jan. 2016
(NPO)日本心臓血管外科学会, Japanese

Stoke Work Index Predicts Left Ventricular Reverse Remodeling
Yasushige Shingu, Satoru Wakasa, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui, JOURNAL OF CARDIAC FAILURE, 21, 10, S157, S157, Oct. 2015
English, Summary international conference

Bridge to recoverとなったHeartmate II装着例に対する治療経験　　　　　　　　　　　　　　　
大岡 智学, 浅井 英嗣, 佐藤 公治, 小林 一哉, 新宮 康栄, 加藤 裕貴, 若狭 哲, 橘 剛, 松居 喜郎, 人工臓器, 44, 2, S, 156, Oct. 2015
(一社)日本人工臓器学会, Japanese

【内科医に必要な心臓外科手術の知識】 治す 進歩する外科手術 DCMはここまで治せる?
松居 喜郎, 若狭 哲, 新宮 康栄, 大岡 智学, 橘 剛, Heart View, 19, 10, 1146, 1152, Oct. 2015
(株)メジカルビュー社, Japanese

心移植直後に発症した、タクロリムスによると思われる横紋筋融解を呈した1例　　　　　　　　　　　　　　　
大岡 智学, 大安 孝允, 佐藤 公治, 小林 一哉, 新宮 康栄, 加藤 裕貴, 若狭 哲, 櫛引 勝年, 小林 真梨子, 松居 喜郎, 移植, 50, 総会臨時, 383, 383, Sep. 2015
(一社)日本移植学会, Japanese

【外科治療における心エコーの役割】 外科医が知りたいFMRのポイント なぜ?どうして?　　　　　　　　　　　　　　　
新宮 康栄, 松居 喜郎, 心エコー, 16, 9, 918, 921, Sep. 2015
(株)文光堂, Japanese

心臓血管 small volume centerにおける慢性血栓性肺高血圧症に対する肺動脈血栓内膜摘除の成績　　　　　　　　　　　　　　　
大岡 智学, 関 達也, 内藤 祐嗣, 新宮 康栄, 若狭 哲, 橘 剛, 松居 喜郎, 日本外科学会定期学術集会抄録集, 115回, OP, 184, Apr. 2015
(一社)日本外科学会, Japanese

北大関連病院データベース(HOCARD)を用いた腹部大動脈瘤破裂の検討　　　　　　　　　　　　　　　
佐藤 公治, 若狭 哲, 浅井 英嗣, 太安 孝允, 関 達也, 内藤 祐嗣, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本心臓血管外科学会雑誌, 44, Suppl., 283, 283, Jan. 2015
(NPO)日本心臓血管外科学会, Japanese

左室形態からみた虚血性心筋症に対する左室形成と乳頭筋接合術の意義　　　　　　　　　　　　　　　
若狭 哲, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本心臓血管外科学会雑誌, 44, Suppl., 343, 343, Jan. 2015
(NPO)日本心臓血管外科学会, Japanese

心大血管再手術138例の検討　　　　　　　　　　　　　　　
内藤 祐嗣, 新宮 康栄, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本心臓血管外科学会雑誌, 44, Suppl., 376, 376, Jan. 2015
(NPO)日本心臓血管外科学会, Japanese

僧帽弁収縮期前方運動と左室流出路狭窄に対する心室中隔切除術の検討　　　　　　　　　　　　　　　
新宮 康栄, 若狭 哲, 大岡 智学, 橘 剛, 杉木 宏司, 松居 喜郎, 日本心臓血管外科学会雑誌, 44, Suppl., 392, 392, Jan. 2015
(NPO)日本心臓血管外科学会, Japanese

末梢吻合部位の深さからみた遠位弓部大動脈瘤に対するstaged repair選択基準の検討　　　　　　　　　　　　　　　
佐藤 公治, 若狭 哲, 浅井 英嗣, 太安 孝允, 関 達也, 内藤 祐嗣, 新宮 康栄, 大岡 智学, 加藤 裕貴, 橘 剛, 松居 喜郎, 日本心臓血管外科学会雑誌, 44, Suppl., 438, 438, Jan. 2015
(NPO)日本心臓血管外科学会, Japanese

遠隔成績を鑑みて、機能性三尖弁閉鎖不全に対する弁輪形成術単独は十分か?　　　　　　　　　　　　　　　
大岡 智学, 関 達也, 内藤 祐嗣, 新宮 康栄, 若狭 哲, 橘 剛, 松居 喜郎, 日本心臓血管外科学会雑誌, 44, Suppl., 236, 236, Jan. 2015
(NPO)日本心臓血管外科学会, Japanese

EVAHEART装着後のMRSA縦隔炎及びポンプポケット感染例に対するJarvik2000換装(左開胸)の経験　　　　　　　　　　　　　　　
大岡 智学, 内藤 祐嗣, 新宮 康栄, 若狭 哲, 橘 剛, 松居 喜郎, 人工臓器, 43, 2, S, 149, Sep. 2014
(一社)日本人工臓器学会, Japanese

北海道における心臓移植報告　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 若狭 哲, 松居 喜郎, 榊原 守, 絹川 真太郎, 筒井 裕之, 小林 真梨子, 久保田 卓, 杉木 宏司, 日本移植学会総会プログラム抄録集, 50回, 431, 431, Aug. 2014
(一社)日本移植学会, Japanese

胸部大動脈 食道瘻に対する治療法の推移とその成績　　　　　　　　　　　　　　　
荒木 大, 若狭 哲, 久保田 卓, 新宮 康栄, 大岡 智学, 橘 剛, 松居 喜郎, 北海道外科雑誌, 59, 1, 37, 43, Jun. 2014
北海道外科学会, Japanese

北海道大学における植込型補助人工心臓治療及び心臓移植実施体制の現状　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 絹川 真太郎, 榊原 守, 筒井 裕之, 小林 真梨子, 浅野 恵子, 寒河江 磨, 法邑 まなみ, 矢萩 亮児, 加藤 伸彦, 移植, 49, 1, 192, 193, May 2014
(一社)日本移植学会, Japanese

PD-2-4 心大血管再手術のPitfalls(PD-2 パネルディスカッション(2)心臓再手術のPitfalls,第114回日本外科学会定期学術集会)
松居 喜郎, 内藤 祐嗣, 新宮 康栄, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 久保田 卓, 日本外科学会雑誌, 115, 2, 171, 171, 05 Mar. 2014
一般社団法人日本外科学会, Japanese

VL-4 大動脈弁形成術を伴うRemodeling法による弁温存大動脈塞部再建術(VL-4 映像による私の手術手技(4),第114回日本外科学会定期学術集会)
松居 喜郎, 新宮 康栄, 若狭 哲, 大岡 智学, 加藤 裕貴, 裕貴 剛, 久保田 卓, 日本外科学会雑誌, 115, 2, 241, 241, 05 Mar. 2014
一般社団法人日本外科学会, Japanese

OP-098-6 大動脈瘤手術時の肋間動脈再建法の検討 : internal cuff reimplantation法の有用性(OP-098 大血管 胸部・その他,一般演題,第114回日本外科学会定期学術集会)
若狭 哲, 内藤 祐嗣, 久保田 卓, 関 達也, 小林 一哉, 新宮 康栄, 大岡 智学, 橘 剛, 松居 喜郎, 日本外科学会雑誌, 115, 2, 489, 489, 05 Mar. 2014
一般社団法人日本外科学会, Japanese

PS-019-1 拡張型心筋症術後のreverse remodelingと術前心仕事量拡張末期容積関係の勾配との関連(PS-019 心臓 虚血性疾患・移植・その他,ポスターセッション,第114回日本外科学会定期学術集会)
新宮 康栄, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 115, 2, 612, 612, 05 Mar. 2014
一般社団法人日本外科学会, Japanese

心臓再手術のPitfalls 心大血管再手術のPitfalls　　　　　　　　　　　　　　　
松居 喜郎, 内藤 祐嗣, 新宮 康栄, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 久保田 卓, 日本外科学会雑誌, 115, 臨増2, 171, 171, Mar. 2014
(一社)日本外科学会, Japanese

大動脈弁形成術を伴うRemodeling法による弁温存大動脈塞部再建術　　　　　　　　　　　　　　　
松居 喜郎, 新宮 康栄, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 久保田 卓, 日本外科学会雑誌, 115, 臨増2, 241, 241, Mar. 2014
(一社)日本外科学会, Japanese

当科におけるTOFの肺動脈二尖弁に対する自己弁温存の術式と変遷　　　　　　　　　　　　　　　
加藤 伸康, 橘 鹿, 浅井 英嗣, 安東 悟央, 関 達也, 小林 一哉, 内藤 裕嗣, 新宮 康栄, 若狭 哲, 加藤 裕貴, 大岡 智学, 久保田 卓, 武田 充人, 松居 喜郎, 日本心臓血管外科学会雑誌, 43, Suppl., 443, 443, Jan. 2014
(NPO)日本心臓血管外科学会, Japanese

オートファジーからみた重症心不全に対する左室形成術の効果
新宮 康栄, 上原記念生命科学財団研究報告集, 27, 1, 5, Dec. 2013
(公財)上原記念生命科学財団, Japanese

悪性リンパ腫の診断における心嚢液細胞診の有用性の検討
浅井 英嗣, 新宮 康栄, 内藤 佑嗣, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本心臓血管外科学会雑誌, 42, 6, 494, 498, Nov. 2013
(NPO)日本心臓血管外科学会, Japanese

Complete Papillary Muscle Approximation is Associated with High Durability of Mitral Valve Repair for Ischemic Mitral Regurgitation
Satoru Wakasa, Yasushige Shingu, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui, JOURNAL OF CARDIAC FAILURE, 19, 10, S114, S114, Oct. 2013
English, Summary international conference

植込型補助人工心臓装着後の課題　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 北海道外科雑誌, 58, 1, 70, 70, Jun. 2013
北海道外科学会, Japanese

VF-048-3 機能的僧帽弁閉鎖不全症に対するpapillary muscle approximation with anterior suspension(VF ビデオフォーラム,第113回日本外科学会定期学術集会)
若狭 哲, 新宮 康栄, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-031-1 TOFに対する肺動脈弁温存/弁輪の工夫(PS ポスターセッション,第113回日本外科学会定期学術集会)
加藤 伸康, 橘 剛, 浅井 英嗣, 関 達也, 南田 太朗, 飯島 誠, 内藤 祐嗣, 新宮 康栄, 若狭 哲, 大岡 智学, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-032-3 ブタ心大動脈基部を用いた大動脈弁逸脱症モデルの構築(PS ポスターセッション,第113回日本外科学会定期学術集会)
関 達也, 新宮 康栄, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-033-4 術後心房細動患者では術後心筋興奮-収縮連関時間が延長している(PS ポスターセッション,第113回日本外科学会定期学術集会)
新宮 康栄, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-034-1 機能性僧帽弁逆流への僧帽弁形成術後に発生する機能性僧帽弁狭窄の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)
南田 大朗, 若狭 哲, 加藤 伸康, 関 達也, 浅井 英嗣, 飯島 誠, 内藤 祐嗣, 新宮 康栄, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-282-3 Marfan症候群における大血管病変に対する治療戦略(PS ポスターセッション,第113回日本外科学会定期学術集会)
内藤 祐嗣, 新宮 康栄, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

VF-048-3 機能的僧帽弁閉鎖不全症に対するpapillary muscle approximation with anterior suspension(VF ビデオフォーラム,第113回日本外科学会定期学術集会)
若狭 哲, 新宮 康栄, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 465, 465, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-031-1 TOFに対する肺動脈弁温存/弁輪の工夫(PS ポスターセッション,第113回日本外科学会定期学術集会)
加藤 伸康, 橘 剛, 浅井 英嗣, 関 達也, 南田 太朗, 飯島 誠, 内藤 祐嗣, 新宮 康栄, 若狭 哲, 大岡 智学, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 560, 560, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-032-3 ブタ心大動脈基部を用いた大動脈弁逸脱症モデルの構築(PS ポスターセッション,第113回日本外科学会定期学術集会)
関 達也, 新宮 康栄, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 562, 562, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-033-4 術後心房細動患者では術後心筋興奮-収縮連関時間が延長している(PS ポスターセッション,第113回日本外科学会定期学術集会)
新宮 康栄, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 563, 563, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-034-1 機能性僧帽弁逆流への僧帽弁形成術後に発生する機能性僧帽弁狭窄の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)
南田 大朗, 若狭 哲, 加藤 伸康, 関 達也, 浅井 英嗣, 飯島 誠, 内藤 祐嗣, 新宮 康栄, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 564, 564, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

PS-282-3 Marfan症候群における大血管病変に対する治療戦略(PS ポスターセッション,第113回日本外科学会定期学術集会)
内藤 祐嗣, 新宮 康栄, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 114, 2, 914, 914, 05 Mar. 2013
一般社団法人日本外科学会, Japanese

心臓・大血管手術における止血法の工夫 TFF(TachoSil-Fibrin-Felt)StripとTF Sheet　　　　　　　　　　　　　　　
松居 喜郎, 若狭 哲, 新宮 康栄, 大岡 智学, 橘 剛, 久保田 卓, 日本心臓血管外科学会雑誌, 42, Suppl., 193, 193, Feb. 2013
(NPO)日本心臓血管外科学会, Japanese

機能性三尖弁閉鎖不全に対する弁輪形成術後中等度以上の遺残閉鎖不全は予測可能か?　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 日本心臓血管外科学会雑誌, 42, Suppl., 363, 363, Feb. 2013
(NPO)日本心臓血管外科学会, Japanese

当科で施行したTOF術後成人期(16歳以上)での再手術症例の検討
KATO NOBUYASU, ASAI HIDETSUGU, SEKI TATSUYA, MINAMIDA TARO, IIJIMA MAKOTO, NAITO YUJI, SHINGU YASUSHIGE, WAKASA SATORU, OOKA TOMONORI, TACHIBANA TSUYOSHI, KUBOTA SUGURU, MATSUI YOSHIRO, 日本成人先天性心疾患学会雑誌, 2, 1, 83, 83, Jan. 2013
日本成人先天性心疾患学会, Japanese

【重症心不全に対する外科治療】 左室形成術の適応と限界　　　　　　　　　　　　　　　
若狭 哲, 新宮 康栄, 久保田 卓, 南田 大朗, 飯島 誠, 内藤 祐嗣, 大岡 智学, 橘 剛, 松居 喜郎, 胸部外科, 66, 1, 26, 30, Jan. 2013
(株)南江堂, Japanese

Anterior papillary muscle suspension prevents impairment of left ventricular inflow in functional mitral regurgitation
SHINGU YASUSHIGE, WAKASA SATORU, OOKA TOMONORI, TACHIBANA TSUYOSHI, KUBOTA SUGURU, MATSUI YOSHIRO, 北海道外科雑誌, 57, 2, 26, 30, Dec. 2012
北海道外科学会, Japanese

機能的僧帽弁逆流に対する前方への乳頭筋つり上げ術は左室流入血流障害を軽減する　　　　　　　　　　　　　　　
新宮 康栄, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 北海道外科雑誌, 57, 2, 130, 134, Dec. 2012
北海道外科学会, Japanese

植込型補助人工心臓承認によって重症心不全治療はどう変わったか? 重症心不全患者に対する左室形成術の成績から見た植込型補助人工心臓装着を含む外科的重症心不全治療戦略　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 人工臓器, 41, 2, S, 33, Nov. 2012
(一社)日本人工臓器学会, Japanese

Left-ventriclar electromechanical delay is prolonged in patients with postperative atrial fibrillation
新宮 康栄, 久保田 卓, 若狭 哲, 夷岡 徳彦, 森 大輔, 大岡 智学, 橘 剛, 松居 喜郎, 北海道醫學雜誌 = Acta medica Hokkaidonensia, 87, 6, 268, 268, 01 Nov. 2012
Japanese

Stoke Work Index Predicts Responder to Mitral Valve Repair in Patients with Idiopathic Dilated Cardiomyopathy and Severe Mitral Regurgitation
Yasushige Shingu, Yoshiro Matsui, JOURNAL OF CARDIAC FAILURE, 18, 10, S160, S160, Oct. 2012
English, Summary international conference

Left Ventriculoplasty and Mitral Complex Reconstruction for Dilated Cardiomyopathy
Yoshiro Matsui, Yasushige Shingu, Satoru Wakasa, Tomonori Ooka, Tsuyoshi Tachibana, Suguru Kubota, JOURNAL OF CARDIAC FAILURE, 18, 10, S134, S134, Oct. 2012
English, Summary international conference

重症左心不全に対する左室形成術後に左室拡張能改善と心筋酸素代謝軽減を認める
千葉知, 納谷昌直, 吉永恵一郎, 岩野弘幸, 山田聡, 若狭哲, 新宮康栄, 久保田卓, 松居喜郎, 筒井裕之, 玉木長良, 核医学, 49, 3, 261, 31 Aug. 2012
Japanese

VWS-1-4 僧帽弁複合体形成術 : 僧帽弁輪縫縮・乳頭筋接合・乳頭筋つり上げ(VWS-1 ビデオワークショップ(1)機能的僧帽弁逆流に対する術式の工夫,第112回日本外科学会定期学術集会)
松居 喜郎, 新宮 康栄, 内藤 祐嗣, 夷岡 徳彦, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 日本外科学会雑誌, 113, 2, 261, 261, 05 Mar. 2012
一般社団法人日本外科学会, Japanese

SF-080-2 傍腎動脈腹部大動脈瘤手術における常温腎動脈上遮断の安全性(SF-080 サージカルフォーラム(80)末梢血管 臨床,第112回日本外科学会定期学術集会)
内藤 祐嗣, 夷国 徳彦, 新宮 康栄, 若狭 哲, 大岡 智学, 加藤 裕貴, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 113, 2, 392, 392, 05 Mar. 2012
一般社団法人日本外科学会, Japanese

SF-105-4 大動脈弁置換術非適応患者の手術危険率予測スコア評価 : 北海道における実情調査アンケート結果(SF-105 サージカルフォーラム(105)心臓,第112回日本外科学会定期学術集会)
関 達也, 新宮 康栄, 榊原 守, 若狭 哲, 大岡 智学, 橘 剛, 久保田 卓, 筒井 裕之, 松居 喜郎, 日本外科学会雑誌, 113, 2, 428, 428, 05 Mar. 2012
一般社団法人日本外科学会, Japanese

PS-107-8 高周波焼灼デバイスを用いたメイズ手術 : 焼灼回数と貫壁性の検討(PS-107 心臓 虚血性疾患,ポスターセッション,第112回日本外科学会定期学術集会)
若狭 哲, 久保田 卓, 新宮 康栄, 大岡 智学, 橘 剛, 松居 喜郎, 日本外科学会雑誌, 113, 2, 706, 706, 05 Mar. 2012
一般社団法人日本外科学会, Japanese

PS-153-2 先天性心疾患に対する右室流出路形成術後の再右室流出路再建例の検討(心臓小児・弁膜症,ポスターセッション,第112回日本外科学会定期学術集会)
浅井 英嗣, 松居 喜朗, 久保田 卓, 橘 剛, 大岡 智学, 若狭 哲, 夷岡 徳彦, 内藤 裕嗣, 新宮 康栄, 南田 太朗, 関 達也, 日本外科学会雑誌, 113, 2, 797, 797, 05 Mar. 2012
一般社団法人日本外科学会, Japanese

PS-153-5 溶血性貧血を伴う人工弁paravalvular leakに対する再置換術の早期手術成績に与える術前因子の検討(心臓小児・弁膜症,ポスターセッション,第112回日本外科学会定期学術集会)
久保田 卓, 関 達也, 浅井 英嗣, 新宮 康栄, 内藤 祐嗣, 夷岡 徳彦, 若狭 哲, 大岡 智学, 橘 剛, 松居 喜郎, 日本外科学会雑誌, 113, 2, 798, 798, 05 Mar. 2012
一般社団法人日本外科学会, Japanese

PS-153-7 SJM Tailor Ringを用いた二次性三尖弁閉鎖不全に対する弁輪形成術 : MC^3 ringとの比較(心臓小児・弁膜症,ポスターセッション,第112回日本外科学会定期学術集会)
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 113, 2, 798, 798, 05 Mar. 2012
一般社団法人日本外科学会, Japanese

PS-154-4 高齢者の大動脈弁置換術の成績(心臓弁膜症,ポスターセッション,第112回日本外科学会定期学術集会)
新宮 康栄, 関 達也, 久保田 卓, 若狭 哲, 大岡 智学, 橘 剛, 松居 喜郎, 日本外科学会雑誌, 113, 2, 799, 799, 05 Mar. 2012
一般社団法人日本外科学会, Japanese

新しい僧帽弁形成術 Measured Tube Techniqueによる人工腱策再建　　　　　　　　　　　　　　　
松居 喜郎, 新宮 康栄, 夷岡 徳彦, 若狭 哲, 杉木 宏司, 大岡 智学, 橘 剛, 久保田 卓, 日本心臓血管外科学会雑誌, 41, Suppl., 345, 345, Mar. 2012
(NPO)日本心臓血管外科学会, Japanese

Surgical strategy for ischemic cardiomyopathy, including surgical ventricular reconstruction, ventricular assist device and heart transplantation
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, Journal of the Japanese Coronary Association, 18, 3, 265, 269, 2012
The Japanese Coronary Association, Japanese

Surgical strategy for ischemic cardiomyopathy, including surgical ventricular reconstruction, ventricular assist device and heart transplantation
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, Journal of the Japanese Coronary Association, 18, 3, 265, 269, 2012
The Japanese Coronary Association, Japanese

静脈血リザーバ併用PCPS閉鎖回路による心筋負荷補助効果の実験的検討
飯島誠, 関達也, 浅井英嗣, 加藤伸康, 南田大朗, 夷岡徳彦, 内藤祐嗣, 新宮康栄, 若狭哲, 大岡智学, 橘剛, 久保田卓, 松居喜郎, 北海道外科雑誌, 56, 2, 160, 161, 20 Dec. 2011
Japanese

北海道初の植込型補助人工心臓を用いた重症心不全治療の経験 院内治療体制構築からHub-Satellite Hospital systemへ　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 北海道外科雑誌, 56, 2, 156, 156, Dec. 2011
北海道外科学会, Japanese

北海道初の植込型補助人工心臓を用いた重症心不全治療の経験 院内治療体制構築からHub-Satellite Hospital systemへ　　　　　　　　　　　　　　　
大岡 智学, 新宮 康栄, 若狭 哲, 橘 剛, 久保田 卓, 松居 喜郎, 人工臓器, 40, 2, S134, S134, Oct. 2011
(一社)日本人工臓器学会, Japanese

Surgical ventricular restoration for ischemic cardiomyopathy
若狭 哲, 新宮 康栄, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, The Japanese journal of thoracic surgery, 64, 11, 985, 988, Oct. 2011
(株)南江堂, Japanese

最新の弁膜症治療 外科治療からカテーテル治療まで 虚血性僧帽弁逆流の外科治療　　　　　　　　　　　　　　　
松居 喜郎, 久保田 卓, 橘 剛, 大岡 智学, 若狭 哲, 新宮 康栄, 日本心臓病学会誌, 6, Suppl.I, 160, 160, Aug. 2011
(一社)日本心臓病学会, Japanese

心不全に対する外科治療 左室形成術と心臓移植、植込型補助人工心臓はどのようにすみ分けるか?　　　　　　　　　　　　　　　
松居 喜郎, 久保田 卓, 橘 剛, 大岡 智学, 若狭 哲, 新宮 康栄, 日本心臓病学会誌, 6, Suppl.I, 172, 172, Aug. 2011
(一社)日本心臓病学会, Japanese

【心不全治療の新展開-外科医との共働による新たな治療戦略】 《心不全に対する外科治療の新展開》 左室形成術・僧帽弁手術
松居 喜郎, 若狭 哲, 新宮 康栄, 杉木 宏司, 大岡 智学, 久保田 卓, 内科, 108, 1, 81, 86, Jul. 2011
(株)南江堂, Japanese

OLEATE CONTROLS THE EFFECTS OF GLP-1 AND EXENDIN-4 ON MYOCARDIAL GLUCOSE UTILIZATION AND CONTRACTILE FUNCTION
Tien Nguyen, Yasushige Shingu, Paulo A. Amorim, Michael Schwarzer, Torsten Doenst, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57, 14, E211, E211, Apr. 2011
English, Summary international conference

Mitral Complex Reconstruction and Left Ventriculoplasty for Functional Mitral Regurgitation With Dilated Cardiomyopathy
Yoshiro Matsui, Satoru Wakasa, Yasushige Shingu, Tomonori Ooka, Tsuyoshi Tachibana, Suguru Kubota, JOURNAL OF CARDIAC FAILURE, 16, 9, S137, S137, Sep. 2010
English, Summary international conference

OP-175-1 非虚血性拡張型心筋症に対する左室形成術の中期成績(心臓-3,一般口演,第110回日本外科学会定期学術集会)
若狭 哲, 新宮 康栄, 松井 欣哉, 大岡 智学, 橘 剛, 久保田 卓, 松居 喜郎, 日本外科学会雑誌, 111, 2, 557, 557, 05 Mar. 2010
一般社団法人日本外科学会, Japanese

TA(Ib)に対するAPC後Af,PATに対してEC conversion,right side MAZEを行った一例
TACHIBANA TSUYOSHI, ABE SHINJI, NAITO YUJI, EBUOKA NORIYOSHI, SHINGU YASUSHIGE, MATSUI KIN'YA, SUGIKI TAKASHI, WAKASA SATOSHI, OOKA TOMONORI, YAMAKAWA SATOSHI, KUBOTA SUGURU, SHIIYA NORIHIKO, MURASHITA TOSHIFUMI, MATSUI YOSHIRO, Gen Thorac Cardiovasc Surg, 57, 8, 7, 10 Aug. 2009
Japanese

拡張型心筋症と僧帽弁閉鎖不全症例における外科治療の心筋酸素代謝に対する効果
杉木孝司, 納谷昌直, 新宮康栄, 松井欣也, 若狭哲, 久保田卓, 椎谷紀彦, 筒井裕之, 玉木長良, 松居喜郎, Gen Thorac Cardiovasc Surg, 57, 8, 15, 10 Aug. 2009
Japanese

¹¹C‐酢酸PETを用いた心筋代謝効率の左室形成術による変化についての検討
杉木孝司, 納谷昌直, 新宮康栄, 松井欣也, 若狭哲, 大岡智学, 久保田卓, 椎谷紀彦, 玉木長良, 筒井裕之, 松居喜郎, 日本心臓血管外科学会雑誌, 38, Supplement, 351, 20 Mar. 2009
Japanese

当科における慢性血栓塞栓性肺高血圧症に対する肺動脈血栓内膜摘除症例の検討　　　　　　　　　　　　　　　
大岡 智学, 夷岡 徳彦, 新宮 康栄, 杉木 孝司, 松井 欣哉, 若狭 哲, 橘 剛, 久保田 卓, 山川 智士, 椎谷 紀彦, 松居 喜郎, 安藤 太三, 日本心臓血管外科学会雑誌, 38, Suppl., 324, 324, Mar. 2009
(NPO)日本心臓血管外科学会, Japanese

VS-008-4 二弁置換手術が必要な人工弁感染及び僧帽弁位人工弁周囲逆流症例におけるManouguian法の工夫 : double-layered patchによるintervalvular fibrous body reconstruction(心臓:後天性疾患,ビデオセッション,第109回日本外科学会定期学術集会)
大岡 智学, 夷岡 徳彦, 新宮 康栄, 杉木 孝司, 松井 欣哉, 若狭 哲, 橘 剛, 久保田 卓, 椎谷 紀彦, 松居 喜郎, 日本外科学会雑誌, 110, 2, 378, 378, 25 Feb. 2009
一般社団法人日本外科学会, Japanese

23) 高度左室拡大及び低左心機能を伴った重症大動脈弁狭窄症に対する手術経験(第99回日本循環器学会北海道地方会)
久保田 卓, 夷岡 徳彦, 新宮 康栄, 松井 欣哉, 杉木 孝司, 若狭 哲, 大岡 智学, 橘 剛, 山川 智士, 椎谷 紀彦, 村下 十志文, 松居 喜郎, Circulation journal : official journal of the Japanese Circulation Society, 72, 0, 1073, 1073, 20 Oct. 2008
社団法人日本循環器学会, Japanese

21) CTによる大動脈弁,僧帽弁石灰化の定量的評価(第99回日本循環器学会北海道地方会)
新宮 康栄, 大山 徳子, 加藤 伸康, 夷岡 徳彦, 杉木 孝司, 若狭 哲, 大岡 智学, 橘 剛, 山川 智士, 久保田 卓, 椎谷 紀彦, 村下 十志文, 松居 喜郎, Circulation journal : official journal of the Japanese Circulation Society, 72, 0, 1073, 1073, 20 Oct. 2008
社団法人日本循環器学会, Japanese

17) 重症左心不全症例に対する左室形成術前後の心筋酸素代謝による評価の検討(第99回日本循環器学会北海道地方会)
杉木 孝司, 納谷 昌直, 新宮 康栄, 松井 欣哉, 久保田 卓, 椎谷 紀彦, 村下 十志文, 松居 喜郎, Circulation journal : official journal of the Japanese Circulation Society, 72, 0, 1073, 1073, 20 Oct. 2008
社団法人日本循環器学会, Japanese

Left ventricular reconstruction for ischemic and non-ischemic dilated cardiomyopathy-overlapping ventriculopasty and muscles approximation/suspension
Yoshiro Matsui, Yasushige Shingu, Takasi Sugiki, Kinya Matsui, Matsul Suguru Kubota, Norihiko Shiiya, JOURNAL OF CARDIAC FAILURE, 14, 7, S139, S139, Sep. 2008
English, Summary international conference

ドクターの目ナースの目どっちも知りたい! 心臓手術と術後管理よくばりガイド 左室形成術(虚血性心筋症を中心に)
上田 裕一, 新宮 康栄, 松居 喜郎, 高橋 利佳, ハートナーシング, 21, 9, 879, 883, Sep. 2008
(株)メディカ出版, Japanese

ドクターの目ナースの目どっちも知りたい! 心臓手術と術後管理よくばりガイド 心筋梗塞合併症手術(心室中隔穿孔手術、心破裂手術)
上田 裕一, 新宮 康栄, 松居 喜郎, 大塚 博明, ハートナーシング, 21, 8, 775, 779, Aug. 2008
(株)メディカ出版, Japanese

急性大動脈解離の保存的降圧療法におけるsivelestat sodium hydrateの有用性
新宮 康栄, 椎谷 紀彦, 松崎 賢司, 国原 孝, 村下 十志文, 松居 喜郎, 胸部外科, 61, 6, 440, 443, Jun. 2008
(株)南江堂, Japanese

【やさしく学べる血小板・血栓止血の管理 研修医からの質問317】 抗血小板療法、抗凝固療法、線溶療法、抗線溶療法 開心・大血管術後管理(CABG、弁置換等)　　　　　　　　　　　　　　　
新宮 康栄, 松居 喜郎, 救急・集中治療, 20, 5-6, 634, 635, Jun. 2008
(株)総合医学社, Japanese

PD-2-5 虚血性心筋症の外科治療戦略 : Overlapping法と僧帽弁複合体形成術(第108回日本外科学会定期学術集会)
新宮 康栄, 夷岡 徳彦, 松井 欣哉, 杉木 孝司, 若狭 哲, 橘 剛, 山川 智士, 久保田 卓, 椎谷 紀彦, 村下 十志文, 松居 喜郎, 日本外科学会雑誌, 109, 2, 123, 123, 25 Apr. 2008
一般社団法人日本外科学会, Japanese

肺動脈絞扼術後のccTGA(SLL),VSD,dextracardiaに対して経左房でconventional repair,TVPを行った1例
TACHIBANA TAKESHI, ABE SHINJI, NAITO HIROSHI, EBISUOKA NORIHIKO, SHINGU YASUSHIGE, MATSUI KIN'YA, SUGIKI KOJI, WAKASA SATOSHI, SUGIKI KOJI, YAMAKAWA SATOSHI, KUBOTA TAKASHI, SHIIYA NORIHIKO, MURASHITA TOSHIFUMI, MATSUI YOSHIRO, Gen Thorac Cardiovasc Surg, 56, 4, 16, 10 Apr. 2008
Japanese

大動脈解離に対するETの長期予後
新宮康栄, 阿部慎司, 内藤祐嗣, 松井欣哉, 若狭哲, 杉木宏司, 橘剛, 山川智士, 久保田卓, 椎谷紀彦, 村下十志文, 松居喜郎, General Thoracic and Cardiovascular Surgery, 56, 4, 2008

左室流出路狭窄を伴う大動脈弁狭窄症に対し弁置換術と心室中隔筋切除を同時施行した2例
阿部慎司, 内藤祐嗣, 新宮康栄, 松井欣哉, 若狭哲, 杉木宏司, 橘剛, 久保田卓, 山川智士, 椎谷紀彦, 村下十志文, 松居喜郎, General Thoracic and Cardiovascular Surgery, 56, 4, 2008

QGSを用いた左室形成術前後壁運動解析
松井欣哉, 阿部慎司, 夷岡徳彦, 内藤祐嗣, 新宮康栄, 杉木孝司, 若狭哲, 杉木宏司, 橘剛, 久保田卓, 山川智士, 椎谷紀彦, 村下十志文, 松居喜郎, General Thoracic and Cardiovascular Surgery, 56, 4, 2008

重症心不全に対する左室形成術による外科治療　　　　　　　　　　　　　　　
松居 喜郎, 新宮 康栄, 若狭 哲, 杉木 孝司, 松井 欣哉, 久保田 卓, 椎谷 紀彦, 村下 十志文, 志村 信一郎, 須藤 幸雄, 適応医学, 11, 2, 50, 56, Jan. 2008
日本適応医学会, Japanese

41)左室縮小率からみたオーバーラッピング型左室形成術後の心機能(第97回日本循環器学会北海道地方会)
新宮 康栄, 松居 喜郎, 内藤 祐嗣, 松井 欣哉, 若狭 哲, 杉木 宏司, 橘 剛, 山川 智士, 久保田 卓, 椎谷 紀彦, 村下 十志文, Circulation journal : official journal of the Japanese Circulation Society, 71, 0, 1010, 1010, 20 Oct. 2007
社団法人日本循環器学会, Japanese

【急性大動脈解離の外科治療】 治療戦略 閉塞型大動脈解離 猶予手術は許容されるか
明神 一宏, 石橋 義光, 石井 浩二, 川崎 正和, 岡 潤一, 國重 英之, 新宮 康栄, 胸部外科, 60, 4, 285, 289, Apr. 2007
(株)南江堂, Japanese

3 Does Cardiac Volume Reduction Surgery with Overlapping Left Ventriculoplasty have Adverse Effect on Left Ventricular Diastolic Function?(Left Ventriculoplasty, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Shingu Yasushige, Kunihara Takashi, Shiiya Norihiko, Murashita Toshifumi, Yamada Satoshi, Onozuka Hisao, Tsutsui Hiroyuki, Matsui Yoshiro, Circulation journal : official journal of the Japanese Circulation Society, 71, 76, 76, 01 Mar. 2007
Japanese Circulation Society, English

シャント閉鎖術後,自家静脈再建術後,再々発上腕動脈瘤の一例
松井欣哉, 椎谷紀彦, 新宮康栄, 杉木孝, 若狭哲, 杉木宏司, 橘剛, 山川智士, 久保田卓, 村下十志文, 松居喜郎, 日本臨床外科学会雑誌, 68, 9, 2007

開心術後のCEDV/RVEFモニタリングによる右室容量と中心静脈圧の変化
新宮康栄, 松井欣哉, 杉木孝司, 若狭哲, 杉木宏司, 橘剛, 山川智士, 久保田卓, 椎谷紀彦, 村下十志文, 松居喜郎, 日本臨床外科学会雑誌, 68, 9, 2007

重症心不全に対する左室形成術のpitfalls
松居喜郎, 杉木宏司, 若狭哲, 新宮康栄, 久保田卓, 椎谷紀彦, 村下十志文, 日本外科系連合学会誌, 32, 3, 2007

上行弓部大動脈置換術後における急性期心機能と脳性ナトリウム利尿ペプチド(BNP)
新宮康栄, 椎谷紀彦, 阿部慎司, 内藤祐嗣, 松井欣哉, 若狭哲, 杉木宏司, 橘剛, 山川智士, 久保田卓, 村下十志文, 松居喜郎, 脈管学, 47, Supplement, 2007

特発性拡張型心筋症に対する左室形成術(オーバーラッピング,乳頭筋接合)施行症例のQGS(quantitative gated SPECT)による局所壁運動・血流量評価
松井欣哉, 新宮康栄, 杉木孝司, 若狭哲, 杉木宏司, 橘剛, 久保田卓, 山川智士, 椎谷紀彦, 村下十志文, 松居喜郎, 吉永恵一郎, 玉木長良, 志村信一郎, 須藤幸雄, General Thoracic and Cardiovascular Surgery, 55, Supplement, 2007

左室縮小率からみたオーバーラッピング型左室形成術後の心機能
新宮康栄, 内藤祐嗣, 松井欣哉, 若狭哲, 杉木宏司, 橘剛, 山川智士, 久保田卓, 椎谷紀彦, 村下十志文, 松居喜郎, General Thoracic and Cardiovascular Surgery, 55, Supplement, 2007

遠位弓部hybrid治療後のステントmigrationの1例
松井欣哉, 椎谷紀彦, 内藤祐嗣, 新宮康栄, 杉木孝司, 若狭哲, 杉木宏司, 橘剛, 松崎賢司, 山川智, 久保田卓, 村下十志文, 松居喜郎, 北海道外科雑誌, 52, 2, 2007

早期血栓閉塞型急性大動脈解離に対する初期保存療法の検討
新宮 康栄, 明神 一宏, 石橋 義光, 石井 浩二, 川崎 正和, 脈管学, 45, 11, 941, 944, Nov. 2005
(一社)日本脈管学会, Japanese

単独CABG後心房細動
新宮 康栄, 青木 秀俊, 大場 淳一, 瀧上 剛, 江屋 一洋, 夷岡 徳彦, 胸部外科, 58, 9, 807, 811, Aug. 2005
(株)南江堂, Japanese

開心術後周術期に発生した急性大動脈解離の3例
滝上 剛, 青木 秀俊, 大場 淳一, 江屋 一洋, 新宮 康栄, 夷岡 徳彦, 日本心臓血管外科学会雑誌, 34, 4, 295, 299, Jul. 2005
(NPO)日本心臓血管外科学会, Japanese

急性A型大動脈解離に対する治療 上行置換か弓部置換か
新宮 康栄, 青木 秀俊, 大場 淳一, 瀧上 剛, 江屋 一洋, 夷岡 徳彦, 胸部外科, 58, 7, 565, 568, Jul. 2005
(株)南江堂, Japanese

31)早期血栓閉塞型急性大動脈解離の治療戦略
新宮 康栄, 明神 一宏, 石橋 義光, 石井 浩二, 川崎 正和, 飯島 啓太郎, Circulation journal : official journal of the Japanese Circulation Society, 67, 760, 760, 20 Apr. 2003
社団法人日本循環器学会, Japanese

【弓部大動脈瘤手術例の遠隔成績】 脳分離体外循環法の長期遠隔成績 弓部大動脈瘤手術例の早期及び遠隔成績
明神 一宏, 石橋 義光, 石井 浩二, 川崎 正和, 山浦 玄武, 新宮 康栄, 胸部外科, 55, 4, 292, 298, Apr. 2002
(株)南江堂, Japanese

胸部外科 2018年 07 月号 [雑誌]
新宮 康栄, 重症非虚血性拡張型心筋症に対する外科治療選択
南江堂, Jul. 2018, [Contributor]

心不全患者の失敗しない弁膜症治療
大門雅夫, 機能的僧帽弁逆流に対する形成術とその問題点
文光堂, Apr. 2017, 4830619368, 136, [Contributor]

心エコーエキスパート完全レシピ
芦原 京美, 渡辺 弘之
メジカルビュー社, 2013, 9784758314022, Japanese, [Contributor]

Open access peer-reviewed Edited Volume Echocardiography　　　　　　　　　　　　　　　
Yasushige Shingu, Evaluation of Subvalvular Apparatus by 2-D Transthoracic Echocardiography
IntechOpen, Jan. 2012, [Joint work]

Can mitral valve replacement be the first-line intervention? - LVAD implantation alone vs. chordal sparing mitral valve replacement with submitral procedures for end-stage heart failure　　　　　　　　　　　　　　　
Yasushige Shingu
THE HEART VALVE SOCIETY 2019 Annual Scientific Meeting ▪ April 11-13, 2019, Spain, 12 Apr. 2019, English, Oral presentation
[International presentation]

Left ventricular stoke work index predicts reverse remodelling after submitral procedures for ischemic dilated cardiomyopathy　　　　　　　　　　　　　　　
Yasushige Shingu
29th Annual Meeting of European Association For Cardio-Thoracic Surgery（EACTS）, 2015, English, Oral presentation
[International presentation]

Misunderstanding about Total Stroke Work in Mitral Regurgitation　　　　　　　　　　　　　　　
Yasushige Shingu
Heart Valve Society 1st Annual Meeting, 2015, English, Oral presentation
[International presentation]

A newly developed tatoal stoke work index predicts survivor after mitral valve repair in end-stage heart failure patients with idiopathic dilated cardiomyopathy　　　　　　　　　　　　　　　
Yasushige Shingu
7th Biennial Congress of the Society for Heart Valve Disease (SHVD 2013), 2013, English, Oral presentation
[International presentation]

How can we estimate left ventricular stroke work in functional mitral regurgitation? –As a predictor for survival after mitral repair-　　　　　　　　　　　　　　　
Yasushige Shingu
21st Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery (ASCVTS 2013), 2013, English, Oral presentation
[International presentation]

A New “Stoke Work Index” Predicts Responder to Mitral Valve Repair in Patients with Idiopathic Dilated Cardiomyopathy and Mitral Regurgitation　　　　　　　　　　　　　　　
Yasushige Shingu
Asian Pacific Society of Cardiology 2013 Congress (APSC 2013), 2013, English, Oral presentation
[International presentation]

Myocardial performance (Tei) index is normal in diastolic and systolic heart failure induced by pressure overload in rats　　　　　　　　　　　　　　　
Yasushige Shingu
European Society of Cardiology, 2010, English, Poster presentation
[International presentation]

Transthoracic Echocardiography According to Clinical Guidelines Reliably Predicts the Stage of Heart Failure in Rats with Pressure Overload　　　　　　　　　　　　　　　
Yasushige Shingu
8th Society for Heart and Vascular Metabolism, 2010, English, Poster presentation
[International presentation]

Comprehensive Echocardiographic Assessment of a Rat Model for Pressure Overload-Induced Heart Failure　　　　　　　　　　　　　　　
Yasushige Shingu
1st Frontier of Cardiovascular Biology, 2010, English, Oral presentation
[International presentation]

Oleate controls the Effect of GLP-1 and Exendin-4 on myocardial glucose utilization and contractile function　　　　　　　　　　　　　　　
Yasushige Shingu
39th Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery, 2010, English, Oral presentation
[International presentation]

心房細動の病態進行における心臓周囲脂肪ミトコンドリア機能の役割　　　　　　　　　　　　　　　
Apr. 2022 - Mar. 2027
渡邉 昌也 新宮 康栄
科研 基盤研究(C), 科研 基盤研究C, Coinvestigator

Cardiac functional recovery by ventricular unloading and autophagy activation
Grants-in-Aid for Scientific Research
Apr. 2022 - Mar. 2027
新宮 康栄
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Principal investigator, 22K08909

培養細胞を用いた脳死下および心停止下ドナーモデルにおける移植心筋障害機序の解明
研究助成（一般）
Sep. 2023 - Mar. 2024
新宮康栄
秋山記念生命科学振興財団, Principal investigator

易傷害性心グラフトの体外灌流修復法と非侵襲的グラフト機能評価法の開発
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Apr. 2020 - Mar. 2023
深井 原, 新宮 康栄, 暮地本 宙己, 木村 太一, 藤好 真人
心移植のドナー不足解消のためには、心臓グラフトの冷保存許容時間の延長、虚血再灌流傷害の軽減が必要である。本課題では心臓の冷保存状態の改善、冠選択的灌流の至適条件、薬剤性コンディショニング、再灌流時治療の効果を明らかにし、移植前グラフト機能評価法の確立を目指す。われわれはラット心の24-36時間冷保存後・移植において、グラフト生存、心機能を比較し、UW液に対する自作液の優位性を示すことに成功した (Wakayama et al 2012 Transplant Int)。今回は自作液とCelsior液で24時間冷保存しその効果をLangendorf灌流による再灌流で比較した。しかし、異所性心移植と異なり自作液の有効性を示し得なかった。そこで、心筋細胞株を用いて自作液の冷保存傷害軽減効果を検討すると共に、各種薬物による保護効果、ミトコンドリア機能保護、細胞質Ca2+ overload阻害の有効性等を検討した。また、心臓のproteomics, metabolomics解析のために抽出法を詳細に検討した。多くの方法を検討した中で、トリクロロ酢酸 (TCA) による除タンパク(沈殿) と代謝物の抽出 (上層)が有用であった。TCA抽出液はジエチルエーテルとの混和・分液によってTCAが除去され、pHが安定した試料が得られるようになった。これらの試料はNMR解析、LC-MS/MS解析、ラマン分光解析に使用できる。一方、ミトコンドリア傷害に先んじて放出される、電子伝達系Complex1の構成分子であるフラビンモノヌクレオチド (FMN) をHPLC蛍光検出により他のビタミンＢ２群と区別する方法を確立した。また、オスミウム浸軟SEM法により心筋細胞内のアクチンやミトコンドリア膜構造を超微形態比較する方法を確立した。
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Coinvestigator, 20K08974

心臓手術後の心房細動を抑え患者さんの負担を減らしたい！　　　　　　　　　　　　　　　
研究クラウドファンディング
Apr. 2019 - Mar. 2022
新宮康栄
academist, Principal investigator, Competitive research funding

カルニチンを用いた心臓弁膜症・肺癌・食道癌術後の心房細動予防　　　　　　　　　　　　　　　
JATS award for transitional clinical research
Apr. 2019 - Mar. 2022
新宮康栄
胸部外科学会, Principal investigator, Competitive research funding

重症機能性僧帽弁逆流症を伴う非虚血性拡張型心筋症に対する僧帽弁手術の遠隔期成績―全国データベース研究　　　　　　　　　　　　　　　
第45回日本心臓財団研究奨励
Apr. 2020
石垣隆弘
Coinvestigator

A new thermally deformable mitral valve annuloplasty ring
Grants-in-Aid for Scientific Research
01 Apr. 2017 - 31 Mar. 2020
Matsui Yoshiro
We developed a novel thermally deformable mitral annuloplasty ring to address the problems in mitral valve surgery. We assessed the ring's mechanical properties and its effect on the mitral valve anatomy. This ring was made of polycaprolactone. In the mechanical tests, the ring's yield point was greater than the deformation force of the annulus in humans. In pigs with deformation from "4:3" to "4:2", the coaptation length was significantly increased in each mitral valve part. Asymmetrical ring deformation increased the coaptation length only at the deformed area. In conclusion, this new thermally deformable mitral annuloplasty ring could be "order-made" to effectively change the coaptation length in all parts of the mitral valve post-deformation via intraoperative heating.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 17K10719

可塑性人工弁輪の開発　　　　　　　　　　　　　　　
科学研究費補助金(基盤研究(C))
Apr. 2017 - Mar. 2019
松居喜郎
文部科学省, Competitive research funding

カルニチンによる心臓弁膜症手術後の心房細動の予防法の開発　　　　　　　　　　　　　　　
Dec. 2017 - Dec. 2018
新宮康栄
楡刀会外科医学研究助成基金, Principal investigator, Competitive research funding

Autophagic preconditioningによる新たな心筋保護法の開発　　　　　　　　　　　　　　　
Oct. 2016 - Oct. 2017
新宮康栄
北海道心臓協会, Principal investigator, Competitive research funding

左室縮小術後のオートファジー制御による新たなアジュバント療法の開発　　　　　　　　　　　　　　　
Oct. 2016 - Oct. 2017
新宮康栄
持田記念財団研究助成, Principal investigator, Competitive research funding

心筋オートファジー活性化による左室縮小術後の心筋肥大抑制　　　　　　　　　　　　　　　
Apr. 2015 - Mar. 2016
新宮康栄
日本心臓財団研究奨励, Principal investigator, Competitive research funding

血中遊離脂肪酸と心筋オートファジーからみた新たな不整脈治療の開発　　　　　　　　　　　　　　　
Apr. 2015 - Mar. 2016
新宮康栄
三井住友循環器学研究振興基金, Principal investigator, Competitive research funding

Postoperative Atrial Fibrillation and Insulin Resistance
Grants-in-Aid for Scientific Research
Apr. 2012 - Mar. 2015
Shingu Yasushige
Subjects were 38 patients who underwent cardio-thoracic surgery. Twenty-four-hours monitoring by electrocardiogram was conducted for the detection of postoperative atrial fibrillation for 7 days after surgery. Excised right atrial muscle was quickly frozen and stored for the gene expression analysis of glucose and fatty acid metabolism. Eighteen patients (47%) presented with postoperative atrial fibrillation (POAF group). The gene expression of fatty acid binding protein 3 (FABP3: fatty acid transporter in myocytes) was significantly reduced in the POAF group than in the non-POAF group. Moreover, in the analysis of 12 patients with insulin resistance, the gene expression of fatty acid translocase (CD36: fatty acid transporter into myocytes) tended to be higher in the POAF group than in the non-POAF group (P=0.08). We demonstrated that there is a correlation between POAF and abnormal gene expression of fatty acid metabolism in the myocardium.
Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, Principal investigator, Competitive research funding, 24791453

術後心房細動患者における心筋興奮—収縮連関時間の延長　　　　　　　　　　　　　　　
同窓会研究助成
Apr. 2012 - Mar. 2013
新宮康栄
フラテ研究奨励賞, Principal investigator, Competitive research funding

オートファジーからみた重症心不全に対する左室形成術の効果　　　　　　　　　　　　　　　
研究奨励金
Apr. 2011 - Mar. 2012
新宮康栄
上原財団, Principal investigator, Competitive research funding

心不全モデルにおけるGLP-1、エネルギー基質の心筋組織呼吸に及ぼす影響　　　　　　　　　　　　　　　
海外留学助成
Apr. 2009 - Mar. 2011
新宮康栄
上原財団, Principal investigator, Competitive research funding

市立札幌開成中等教育学校におけるアウトリーチ活動　　　　　　　　　　　　　　　
17 Nov. 2023 - 17 Nov. 2023
Lecturer
Visiting lecture
北海道大学大学院医学研究院 心臓血管外科学教室
「北大から心臓移植のエキスパートが来ます！」

市立札幌開成中等教育学校におけるアウトリーチ活動（心臓移植医療の啓蒙と研究紹介）
Nov. 2023
秋山記念生命科学振興財団
アウトリーチ活動
https://www.akiyama-foundation.org/news/6316.html, 43363745, [Internet]

プレスリリース_トレハロースによる虚血後の心機能改善にはじめて成功　　　　　　　　　　　　　　　
Feb. 2021
北海道大学
プレスリリース
https://www.hokudai.ac.jp/news/2021/02/post-797.html, [Internet]

クラウドファンディングに成功した研究者・新宮康栄さんのサイエンスカフェ　　　　　　　　　　　　　　　
07 Nov. 2018
北海道大学
いいね！Hokudai
[Internet]

心臓手術後の合併症「心房細動」をカルニチンで予防　　　　　　　　　　　　　　　
13 Jul. 2018
北海道大学
いいね！Hokudai
[Internet]