2019, The Japanese Society for Surgery of the Foot, JSSF Korea-Japan Travelling fellowship　　　　　　　　　　　　　　　

Sep. 2018, 日本医師会, 日本医師会医学研究奨励賞　　　　　　　　　　　　　　　
小野寺智洋

Sep. 2018, 日本整形外科学会, 日整会Travelling Fellowship（Korean Orthopaedic Association Annual Congress）　　　　　　　　　　　　　　　
小野寺智洋

2013, 整形災害外科学研究助成財団, アルケア奨励賞　　　　　　　　　　　　　　　
小野寺智洋

2012, 北海道整形災害外科学会, 学術奨励賞　　　　　　　　　　　　　　　
小野寺智洋

Sep. 2011, 北海道大学大学院医学研究科, 第30回 高桑榮松奨学基金奨励賞　　　　　　　　　　　　　　　
小野寺智洋

2011, 北海道大学医学部同窓会, フラテ研究奨励賞　　　　　　　　　　　　　　　
小野寺智洋

Sep. 2007, JSPS, JSPS Postdoctoral Fellowship for Research Abroad　　　　　　　　　　　　　　　
Tomohiro Onodera

Sep. 2007, NIH, The Fellows Award for Research Excellence　　　　　　　　　　　　　　　
Tomohiro Onodera

Tendon Tissue Regeneration With Cell Orientation Using an Injectable Alginate-Cell Cross-linked Gel.
Jun Yamaguchi, Kentaro Homan, Tomohiro Onodera, Masatake Matsuoka, Shoutaro Arakawa, Natsumi Ueda, Shiho Sawada, Nana Kawate, Takayuki Nonoyama, Yoshinori Katsuyama, Koji Nagahama, Mitsuru Saito, Norimasa Iwasaki
The American journal of sports medicine, 3635465251325498, 3635465251325498, 23 Mar. 2025, [International Magazine]
English, Scientific journal, BACKGROUND: Tendons have a limited blood supply and form inferior scar tissue during repair, which increases the risk of reruptures, causes complications, and limits regenerative capacity. Current methods to repair injured tendon tissue use solid scaffolds, which carry the risk of contamination (infections) and require open surgery for transplantation. HYPOTHESIS: Alginate-cell cross-linked gels, which can be applied by a percutaneous injection and transmit mechanical stress to cells via direct cell interaction, could induce tendon tissue regeneration. STUDY DESIGN: Controlled laboratory study. METHODS: A cross-linked gel was prepared to suspend azide-modified mesenchymal stromal cells (MSCs) in a dibenzocyclooctyne-modified branched alginic acid solution. The cross-linked gel was cultured in a bioreactor. In vivo, the Achilles tendon defects of 104 Lewis rats were injected with saline (control group), alginate gel alone (alginate group), alginate gel with MSCs (MSC group), and cross-linked gel (cross-link group). At 2 and 4 weeks postoperatively, histological and biochemical evaluations were performed. The biomechanical properties of repaired tissue were assessed at 4 weeks. RESULTS: In the bioreactor culture, the cell orientation in the cross-linked gel was parallel to the direction of tension. Histological analysis of the cross-link group showed significantly more repaired tendon tissue and improved collagen fiber orientation compared with the alginate group or MSC group. The biomechanical properties of the cross-link group included higher stiffness. CONCLUSION: The cross-linked gel was injectable at the injury site and was able to induce tissue regeneration with cell-oriented adaptability to the mechanical environment of tissue defects. CLINICAL RELEVANCE: Intercellular cross-linking technology holds the potential for clinical application as a minimally invasive therapeutic approach that can contribute to the qualitative improvement of tendon tissue regeneration.

Progressive subchondral bone cyst formation following autologous chondrocyte implantation with all-suture anchors: a Case Report with histological evaluation.
Takuma Kaibara, Eiji Kondo, Masatake Matsuoka, Koji Iwasaki, Tomohiro Onodera, Daisuke Momma, Zen-Ichi Tanei, Shinya Tanaka, Norimasa Iwasaki
BMC musculoskeletal disorders, 26, 1, 115, 115, 04 Feb. 2025, [International Magazine]
English, Scientific journal, BACKGROUND: Subchondral bone cysts (SBCs) can significantly impact the outcomes of cartilage repair procedures such as autologous chondrocyte implantation (ACI). However, the etiology and progression of SBCs following ACI remain poorly understood. This case report highlights a progressively enlarging SBC following ACI using all-suture anchors, treated with autologous osteochondral transplantation (AOT). CASE PRESENTATION: A 58-year-old female with progressive right knee pain, varus alignment, and Kellgren-Lawrence grade 3 osteoarthritis underwent atelocollagen-associated ACI combined with medial opening wedge high tibial osteotomy. Longitudinal radiological assessment revealed bone hole enlargement corresponding to all-suture anchor sites, with one hole continuing to expand up to 15 months postoperatively, reaching a size of 11 × 13 × 13 mm. This expanding SBC exhibited a connection to the joint cavity via a tiny fissure, scant osteosclerotic rim on CT, and fluid intensity on MRI. Histological analysis of tissue obtained during subsequent AOT revealed several findings. The SBC was located at the anterior portion of the medial femoral condyle, just beneath the all-suture anchor. Osteochondral necrosis was observed surrounding the anchor site, with no evidence of foreign body reaction. The cyst was filled with a mucoid substance and featured an aggregation of foamy macrophages. A sclerotic wall indicative of a strain response was observed. Notably, the presence of osteoclasts along the adjacent bone surface indicated ongoing bone resorption. The patient underwent AOT, which resulted in confirmed bone union. Postoperative follow-up demonstrated successful integration of the osteochondral graft and improved knee function scores over three years. CONCLUSION: This case report documents SBC formation following knee surgery with all-suture anchors and provides histological evaluation of such a cyst. The observed histological findings may contribute to our understanding of SBC pathophysiology in the context of cartilage repair procedures. This case underscores the importance of secure suturing techniques in high-stress areas and suggests the potential benefit of extended post-operative monitoring of SBC progression beyond one year. These observations may inform future strategies for the early detection of SBC formation and its progression, as well as timely intervention to prevent further joint damage in similar cases, though further research is needed to establish broader clinical implications.

Survival outcomes in non-operative cases of localized extremity sarcoma.
Masatake Matsuoka, Tomohiro Onodera, Koji Iwasaki, Masanari Hamasaki, Taku Ebata, Yoshiaki Hosokawa, Eiji Kondo, Norimasa Iwasaki
Surgical oncology, 58, 102181, 102181, Feb. 2025, [International Magazine]
English, Scientific journal, BACKGROUND: Soft-tissue sarcomas (STSs) are a diverse group of malignancies challenging to treat when surgery is not an option. The aim of this study was to investigate the survival of non-surgical cases in STSs, and to examine the impact of radiation therapy (RT) on survival within this group of cases. METHODS: Utilizing the SEER database, we conducted a retrospective cohort study of localized extremity non-small round cell sarcoma diagnosed between 2000 and 2019. A total of 444 non-operative cases were identified and analyzed for cancer-specific survival (CSS) and overall survival (OS) using Kaplan-Meier and Cox proportional hazards models. RESULTS: Among the non-operative cohort, the median age at diagnosis was 72 years. The median survival was 10 months, with AJCC 8th edition clinical stage-specific 5-year CSS rates of 80 % for Stage 1B, 53 % for Stage 2, 47 % for Stage 3A, and 22 % for Stage 3B. The 5-year OS rates were 56 % for Stage 1B, 31 % for Stage 2, 26 % for Stage 3A, and 14 % for Stage 3B. Nearly half of the patients received RT, which was more prevalent in higher clinical stages. RT was associated with improved survival rates for both CSS and OS in patients who are unable to undergo surgical intervention. CONCLUSIONS: RT is associated with improved survival in non-operative localized extremity non-small round cell sarcoma patients. These insights are vital for clinical decision-making, emphasizing the need for personalized, non-surgical interventions to improve outcomes for patients where surgery is not feasible.

Intra-Articular Administration of Ganglioside Sugars Protects Cartilage from Progressive Degeneration in an Instability OA Rabbit Model.
Masanari Hamasaki, Tomohiro Onodera, Junichi Furukawa, Masahiro Todoh, Yuma Sakai, Taku Ebata, Mohamad Alaa Terkawi, Kentaro Homan, Norimasa Iwasaki
Cartilage, 19476035241311542, 19476035241311542, 14 Jan. 2025, [International Magazine]
English, Scientific journal, OBJECTIVE: Osteoarthritis (OA) is a degenerative joint disease that has no cure, and current therapies are intended to minimize pain. There is, therefore, a need for effective pharmacologic agents that reverse or slow the progression of joint damage. We report herein on an investigation of the effects of intra-articular injections of ganglioside sugars on the progression of OA in an experimental rabbit model. DESIGN: Knee OA was induced Japanese in White rabbits by anterior cruciate ligament transection (ACLT). Ganglioside sugars at concentrations of 0.1, 0.3, and 0.9 mg/ml were then intra-articularly injected as a possible treatment for OA. Controls received intra-articular injections of saline. Knees were assessed macroscopically, histologically, and mechanically at 13 weeks after ACLT induction. RESULTS: Macroscopically, knees of the groups that received ganglioside sugars at concentrations of 0.3 and 0.9 mg/ml exhibited milder cartilage degradation compared to the controls. Consistent with these results, histological scores for these knees were significantly higher than the corresponding values for the control knees. Lectin histochemistry staining revealed that the treatment with ganglioside sugars at concentrations of 0.3 and 0.9 mg/ml was associated with a remarkable increase in the levels of GalNAc-positive chondrocytes in cartilage. Coefficient of friction testing also demonstrated that cartilages treated with ganglioside sugars had a lower coefficient of frictions than the values for the control group. CONCLUSIONS: Intra-articular injections of ganglioside sugars prevented cartilage degeneration in an OA-instability model. These results highlight the promising therapeutic potential for using ganglioside sugars in the treatment of progressive OA.

Cellular communication network factor 3 contributes to the pathological process of rheumatoid arthritis through promoting cell senescence and osteoclastogenesis in the joint.
Taiki Tokuhiro, Gen Matsumae, Tsutomu Endo, Yuki Ogawa, Takuya Ogawa, Chen Liyile, Yoshio Nishida, Hend Alhasan, Hideyuki Kobayashi, Taku Ebata, Tomohiro Shimizu, Daisuke Takahashi, Tomohiro Onodera, Ken Kadoya, M Alaa Terkawi, Norimasa Iwasaki
Journal of autoimmunity, 149, 103334, 103334, Dec. 2024, [International Magazine]
English, Scientific journal, Rheumatoid arthritis (RA) is a chronic systemic and autoimmune disease that primarily affects joints and causes pain, stiffness and swelling. The affected joints exhibit severe inflammation in the synovium and bone erosion, leading to joint deformity. Aging is an important factor facilitating the development of RA, as it is associated with an increase in the number of senescent cells and the production of the autoantibodies and proinflammatory cytokines in tissues. Given that CCN3 is highly expressed in RA joints and that its level is associated with the severity of the disease, we explored its molecular function in joints and therapeutic potential in RA. An analysis of public scRNA-seq data from the RA synovium revealed that CCN3 is expressed by an inflammatory fibroblast subset. Interestingly, stimulation with CCN3 resulted in the activation of the senescence pathway in synoviocytes and osteoclast differentiation in monocytes in vitro. Consistent with these results, the administration of CCN3 into the knee joint and onto the calvarial bone resulted in increased numbers of senescent synoviocytes in the joint and osteoclasts in the bone, respectively. Furthermore, the therapeutic potential of targeting CCN3 was evaluated in an experimental RA model. Administration of the CCN3 antibody significantly suppressed inflammation and osteoclast numbers in the joints of the RA model mice. Our findings suggest that CCN3 contributes to pathological processes in RA and represents a promising therapeutic target for the treatment of RA.

Chondroprotective functions of neutrophil-derived extracellular vesicles by promoting the production of secreted frizzled-related protein 5 in cartilage.
Keita Kitahara, Taku Ebata, Chen Liyile, Yoshio Nishida, Yuki Ogawa, Taiki Tokuhiro, Junki Shiota, Tatsuya Nagano, Taichi E Takasuka, Tsutomu Endo, Tomohiro Shimizu, Hend Alhasan, Tsuyoshi Asano, Daisuke Takahashi, Kentaro Homan, Tomohiro Onodera, Ken Kadoya, M Alaa Terkawi, Norimasa Iwasaki
Cell communication and signaling : CCS, 22, 1, 569, 569, 27 Nov. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: Osteoarthritis (OA) is the most common degenerative joint disease characterized by cartilage degradation and various degrees of inflammation in the synovium. Growing evidence highlights that neutrophil extracellular vesicles (EVs) play a protective role in arthritic joints by promoting the resolution of inflammation and the synthesis of proteoglycans in cartilage. However, this homeostatic function is dependent on the activation state of neutrophils and the surrounding environment/tissues. Hence, we explored the chondroprotective functions of neutrophil-derived EVs under different stimulation conditions and the underlying molecular mechanism. METHODS: Human blood-derived neutrophils, murine bone marrow-derived neutrophils, C-28I2 cells and primary chondrocytes were used. Neutrophils were stimulated with different cytokines, and their EVs were isolated for chondrocyte stimulation and further subjected to RNA-sequencing analysis. Two experimental murine OA models were used, and the treatment was performed by intraarticular injections. RESULTS: Conditioned medium from neutrophils stimulated with TGF-β (N-β) had the greatest inhibitory effect on the expression of catabolic factors in stimulated chondrocytes. These protective effects were not impaired when conditioned medium of N-β from AnxA1-deficient mice was used. Consistent with these results, EVs isolated from N-β significantly reduced the expression of catabolic factors in stimulated chondrocytes. Bulk RNA-seq analysis revealed that secreted frizzled-related protein 5 (SFRP5) is upregulated in N-β-EV-stimulated chondrocytes. Furthermore, recombinant SFRP5 treatment significantly reduced the expression of catabolic factors in vitro and catabolic process in experimental murine OA models. CONCLUSIONS: The current study emphasizes the potential therapeutic application of neutrophils in OA and provides new knowledge on the molecular mechanisms underlying their function.

Associations between glycan signature alterations and the cellular antigenic properties of passaged chondrocytes
Kentaro Homan, Taiki Tokuhiro, Tomohiro Onodera, Hisatoshi Hanamatsu, Jun-ichi Furukawa, Taku Ebata, Masatake Matsuoka, Ken Kadoya, M. Alaa Terkawi, Norimasa Iwasaki
Frontiers in Immunology, 15, Frontiers Media SA, 25 Nov. 2024
Scientific journal, Background

Cartilage repair is a significant clinical challenge because of the limited intrinsic healing capacity. Current therapeutic strategies, such as cell transplantation therapy, aim to overcome this challenge by replacing damaged tissue with healthy cells. However, the long-term survival and functionality of transplanted cells remain major hurdles.

Objective

This study investigated the impact of chondrocyte passaging on glycan profiles and their antigenic properties. We hypothesized that alterations in glycan composition due to passaging may contribute to the enhanced ability to activate macrophages, thereby affecting the outcome of cell transplantation therapy.

Methods

Peritoneal macrophages and primary articular chondrocytes were isolated from C57BL/6 mice to establish direct and indirect coculture models. Macrophage activation was assessed by measuring the concentrations of IL-6 and nitric oxide in the culture supernatants or their gene expression. Glycome analysis of various glycoconjugates was performed by glycoblotting methods combined with the SALSA procedure for N-glycans and GSLs and the BEP method for O-glycans.

Results

Our results revealed that direct coculture of macrophages with passaged chondrocytes increased the production of proinflammatory cytokines, including IL-6 and NO, as the number of passages increased. With increasing passage number, the expression of GD3 substantially decreased, and the expression of GM3, especially GD1a, significantly increased. Coculturing passaged GM3S knockout chondrocytes with macrophages significantly suppressed IL-6 expression, implying reduced macrophage activation.

Conclusion

The observed activation of macrophages due to alterations in the glycan profile of chondrocytes provides a possible explanation for the antigenicity and immune rejection of transplanted cells.

CCR7 depletion alleviates bony growth imbalance following physeal injury in mice.
WooYoung Kim, Yuko Sakai, Masatake Matsuoka, Yoshiaki Hosokawa, Ryuichi Fukuda, Kentaro Homan, Tomohiro Onodera, Norimasa Iwasaki
Scientific reports, 14, 1, 24891, 24891, 22 Oct. 2024, [International Magazine]
English, Scientific journal, Growth plates are the frequent sites of skeletal injury in children, leading to skeletal growth imbalances. Chemokines, including the receptor CCR7, play a crucial role in stem cell recruitment and cartilage homeostasis, with previous studies linking CCR7 to osteoarthritis progression. However, its role in growth plate cartilage remains unclear. We analyzed the role of CCR7 in the physeal cartilage repair process in mice model. Physeal injury was created in the proximal tibia in 3-week-old C57BL/6 mice (WT) and CCR7-knockout mice (CCR7-/-). Tibial length was measured macroscopically and sections of the physeal injury were analyzed histologically and immunohistochemically. Height and bone volume of the tibial growth plate and bone mineral density (BMD) of the subchondral area were measured by micro-CT. Mesenchymal stem cells (MSCs) were harvested and gene expression after osteogenic differentiation was analyzed using qRT-PCR. At 1, 3 and 5 weeks postoperatively, injured tibiae of CCR7-/- mice were less shortened than those of WT mice. Bone volume of the physeal bridge was significantly lower in CCR7-/- mice than in WT mice. In contrast, BMD of the subchondral area was comparable between CCR-/- and WT mice, and between sham and operated tibiae. In osteogenic differentiation, CCR7-/- mice showed significantly lowered expression of osteogenic markers such as Osterix, Runx2 and Type X collagen. We demonstrated CCR7 depletion in mice inhibited physeal bridge formation and ameliorated growth imbalances after physeal injury.

Evaluating the Alignment of Artificial Intelligence-Generated Recommendations With Clinical Guidelines Focused on Soft Tissue Tumors.
Masatake Matsuoka, Tomohiro Onodera, Ryuichi Fukuda, Koji Iwasaki, Masanari Hamasaki, Taku Ebata, Yoshiaki Hosokawa, Eiji Kondo, Norimasa Iwasaki
Journal of surgical oncology, 05 Sep. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: The integration of artificial intelligence (AI), particularly, in oncology, has significantly shifted the paradigms of medical diagnostics and treatment planning. However, the utility of AI, specifically OpenAI's ChatGPT, in soft tissue sarcoma treatment, remains unclear. METHODS: We evaluated ChatGPT's alignment with the Japanese Orthopaedic Association (JOA) clinical practice guidelines on the management of soft tissue tumors 2020. Twenty-two clinical questions (CQs) were formulated to encompass various aspects of sarcoma diagnosis, treatment, and management. ChatGPT's responses were classified into "Complete Alignment," "Partial Alignment," or "Nonalignment" based on the recommendation and strength of evidence. RESULTS: ChatGPT demonstrated an 86% alignment rate with the JOA guidelines. The AI provided two instances of complete alignment and 17 instances of partial alignment, indicating a strong capability to match guideline criteria for most questions. However, three discrepancies were identified in areas concerning the treatment of atypical lipomatous tumors, perioperative chemotherapy for synovial sarcoma, and treatment strategies for elderly patients with malignant soft tissue tumors. Reassessment with guideline input led to some adjustments, revealing both the potential and limitations of AI in complex sarcoma care. CONCLUSION: Our study demonstrates that AI, specifically ChatGPT, can align with clinical guidelines for soft tissue sarcoma treatment. It also underscores the need for continuous refinement and cautious integration of AI in medical decision-making, particularly in the context of treatment for soft tissue sarcoma.

変形性膝関節症患者における歩行中の脛骨粗面加速度と脛骨近位の軟骨下骨の骨密度分布との関連性の検討
佐橋 健人, 岩崎 浩司, 安倍 雄一郎, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 遠山 晴一
日本整形外科学会雑誌, 98, 8, S2016, S2016, (公社)日本整形外科学会, Sep. 2024
Japanese

変形性膝関節症における血清中N型糖鎖バイオマーカーの網羅的解析
小野寺 智洋, 宝満 健太郎, 花松 久寿, 古川 潤一, 岩崎 浩司, 松岡 正剛, 濱崎 雅成, 江畑 拓, 坂本 圭太, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 98, 8, S1768, S1768, (公社)日本整形外科学会, Sep. 2024
Japanese

継代培養に伴う糖鎖抗原の変化と自家細胞における免疫応答の発現
宝満 健太郎, 徳廣 泰貴, 小野寺 智洋, 花松 久寿, 古川 潤一, 江畑 拓, Terkawi Alaa, 松岡 正剛, 角家 健, 岩崎 倫政
日本整形外科学会雑誌, 98, 8, S1844, S1844, (公社)日本整形外科学会, Sep. 2024
Japanese

同位体顕微鏡による関節軟骨内水動態の可視化
松ヶ崎 圭純, 小野寺 智洋, 宝満 健太郎, 亀田 浩之, 工藤 與亮, 坂本 直哉, 細川 吉暁, 松岡 正剛, 福田 龍一, 坂井 裕子, 岩崎 倫政
日本整形外科学会雑誌, 98, 8, S1932, S1932, (公社)日本整形外科学会, Sep. 2024
Japanese

Higher association of articular surface destruction with rheumatoid forefoot deformity arising from dislocation of the metatarsophalangeal joints in the lateral column.
Yuki Suzuki, Tomohiro Onodera, Koji Iwasaki, Masatake Matsuoka, Masanari Hamasaki, Eiji Kondo, Norimasa Iwasaki
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 14 Aug. 2024, [Domestic magazines]
English, Scientific journal, BACKGROUND: To evaluate the relationship between the pattern and severity of metatarsophalangeal (MTP) joint dislocation in the lesser toes and severity of joint destruction in rheumatoid forefoot deformities. METHODS: Participants comprised of 13 patients (16 feet) who underwent resection arthroplasty of the metatarsal head of the lesser toes for rheumatoid arthritis of the MTP joints. Correlations between preoperative radiographic findings and histological grades second to fifth metatarsal heads taken intraoperatively were analyzed. RESULTS: In 62 metatarsal heads, complete dislocation of the MTP joint in the lesser toes significantly resulted in severe joint destruction compared to mild or moderate dislocation (P < 0.05). The proportion of severe cartilage damage in MTP joints with complete dislocation was 100 % in the 5th MTP joint, 83.3 % in the 4th MTP joint, and 58.3 % in the 2nd and 3rd MTP joints. Moreover, complete dislocation of the MTP joints in the lateral column showed the most severe joint destruction compared to that in the medial column (P = 0.03). CONCLUSION: Complete dislocation of the MTP joint in the lateral column is related to joint destruction in rheumatoid forefoot deformities.

Amputation surgery associated with shortened survival in patients with localized extremity bone sarcoma.
Nayuhito Yanagisawa, Masatake Matsuoka, Tomohiro Onodera, Koji Iwasaki, Masanari Hamasaki, Taku Ebata, Yoshiaki Hosokawa, Eiji Kondo, Norimasa Iwasaki
Journal of orthopaedics, 54, 124, 130, Aug. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: This study assesses survival rates among patients with localized extremity bone sarcoma who have undergone amputation, pinpointing subpopulations that are disproportionately affected by amputation-related survival disparities. METHODS: Examination of data was conducted using the Surveillance, Epidemiology, and End Results (SEER) program, analyzing records of 3765 patients diagnosed with localized extremity bone sarcoma between 2000 and 2019. Of these, 857 received amputations (Amputation cohort), and 2908 underwent limb-sparing surgeries. Propensity score matching, considering demographic and clinical features, was utilized to ensure a fair comparison. RESULTS: Following propensity score matching, the study focused on 1714 cases. The Amputation cohort was observed to have significantly poorer survival rates (Cancer-Specific Survival [CSS]: Hazard Ratio [HR] = 1.28, 95% Confidence Interval [CI]: 1.05-1.55; Overall Survival [OS]: HR = 1.37, 95% CI: 1.15-1.63). Subsequent subgroup analysis indicated that individuals with tumors exceeding 8 cm in size or those located in the lower limbs were notably at a higher risk of shortened survival (for tumors >8 cm - CSS: HR = 1.32, 95% CI: 1.02-1.71; OS: HR = 1.39, 95% CI: 1.09-1.76; for lower limb tumors - CSS: HR = 1.25, 95% CI: 1.01-1.54; OS: HR = 1.33, 95% CI: 1.11-1.61). CONCLUSIONS: Our findings demonstrate that patients diagnosed with localized extremity bone sarcoma undergoing amputation exhibit lower survival rates, especially in cases involving tumors of greater size or those situated in the lower limbs. In patient groups where amputation is inevitable, careful follow-up is required after surgical intervention.

Depletion of b-series ganglioside prevents limb length discrepancy after growth plate injury.
Yoshiaki Hosokawa, Masatake Matsuoka, Yuko Sakai, Ryuichi Fukuda, Keizumi Matsugasaki, Kentaro Homan, Jun-Ichi Furukawa, Tomohiro Onodera, Norimasa Iwasaki
BMC musculoskeletal disorders, 25, 1, 565, 565, 20 Jul. 2024, [International Magazine]
English, Scientific journal, INTRODUCTION: Growth plate damage in long bones often results in progressive skeletal growth imbalance and deformity, leading to significant physical problems. Gangliosides, key glycosphingolipids in cartilage, are notably abundant in articular cartilage and regulate chondrocyte homeostasis. This suggests their significant roles in regulating growth plate cartilage repair. METHODS: Chondrocytes from 3 to 5 day-old C57BL/6 mice underwent glycoblotting and mass spectrometry. Based on the results of the glycoblotting analysis, we employed GD3 synthase knockout mice (GD3-/-), which lack b-series gangliosides. In 3-week-old mice, physeal injuries were induced in the left tibiae, with right tibiae sham operated. Tibiae were analyzed at 5 weeks postoperatively for length and micro-CT for growth plate height and bone volume at injury sites. Tibial shortening ratio and bone mineral density were measured by micro-CT. RESULTS: Glycoblotting analysis indicated that b-series gangliosides were the most prevalent in physeal chondrocytes among ganglioside series. At 3 weeks, GD3-/- exhibited reduced tibial shortening (14.7 ± 0.2 mm) compared to WT (15.0 ± 0.1 mm, P = 0.03). By 5 weeks, the tibial lengths in GD3-/- (16.0 ± 0.4 mm) closely aligned with sham-operated lengths (P = 0.70). Micro-CT showed delayed physeal bridge formation in GD3-/-, with bone volume measuring 168.9 ± 5.8 HU at 3 weeks (WT: 180.2 ± 3.2 HU, P = 0.09), but normalizing by 5 weeks. CONCLUSION: This study highlights that GD3 synthase knockout mice inhibit physeal bridge formation after growth plate injury, proposing a new non-invasive approach for treating skeletal growth disorders.

Radiation therapy improves survival in elderly patients with localized extremity soft tissue sarcoma.
Masatake Matsuoka, Tomohiro Onodera, Koji Iwasaki, Masanari Hamasaki, Taku Ebata, Yoshiaki Hosokawa, Ryuichi Fukuda, Eiji Kondo, Norimasa Iwasaki
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 15 Jul. 2024, [Domestic magazines]
English, Scientific journal, BACKGROUND: This study aims to evaluate the efficacy of radiation therapy in enhancing survival outcomes among elderly patients diagnosed with localized extremity soft tissue sarcomas (STSs). Furthermore, it seeks to explore whether the survival benefits conferred by radiation therapy differ according to tumor characteristics and treatment modalities. METHODS: We conducted a retrospective analysis using the Surveillance, Epidemiology, and End Results (SEER) database to identify patients aged 80 years and older diagnosed with localized extremity STSs. The study assessed 1498 eligible patients, analyzing cancer-specific survival (CSS) and overall survival (OS) through Kaplan-Meier survival analysis and Cox proportional hazards modeling. Propensity score matching was employed to adjust for potential confounders. RESULTS: Among the analyzed patients, 773 patients underwent radiation therapy (Radiation group), while 725 patients either did not receive radiation therapy or it was unknown if they had (No-Radiation group). The 5-year OS rate was 40% in the radiation group compared to 38% in the no-radiation group. After propensity score matching, radiation therapy was associated with a significant improvement in OS (P = 0.005, HR = 0.8, 95% CI 0.7-0.9). Subgroup analyses indicated that patients undergoing primary tumor resection benefited most from radiation therapy in terms of OS. CONCLUSION: Radiation therapy is associated with improved overall survival in elderly patients with localized extremity STSs. These findings suggest that radiation therapy should be considered as a key component of the treatment strategy for this patient population, taking into account individual patient characteristics and comorbidities.

Paradoxical Change in Subchondral Bone Density in the Medial Compartment of the Proximal Tibial Articular Surface After High Tibial Osteotomy: A Detailed Subchondral Bone Density Analysis.
Yuki Fujie, Koji Iwasaki, Masanari Hamasaki, Yuki Suzuki, Masatake Matsuoka, Tomohiro Onodera, Eiji Kondo, Norimasa Iwasaki
The American journal of sports medicine, 52, 9, 3635465241256100, 3635465241256100, 20 Jun. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: High tibial osteotomy (HTO) aims to realign the varus knee to alleviate stress in the medial compartment. However, detailed information on the impact of HTO on stress distribution across the tibiofemoral joint surface still needs to be completely elucidated. PURPOSE/HYPOTHESIS: The present study aimed to analyze the subchondral bone density distribution to validate the alignment threshold causing paradoxical changes. We hypothesized that there would be a paradoxical stress change in the medial compartment beyond a specific threshold for lower limb realignment after HTO. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: A retrospective clinical study of 32 knees from 30 patients who underwent medial opening-wedge HTO between 2015 and 2019 was conducted at Hokkaido University Hospital. The subchondral bone density across the tibiofemoral joint was analyzed using computed tomography-osteoabsorptiometry before and after HTO. The high-density area (HDA) within the medial and lateral compartments and their subregions, which were quartered in the coronal plane, was specifically examined. RESULTS: The hip-knee-ankle angle, medial proximal tibial angle (MPTA), joint line obliquity (JLO), and joint line convergence angle significantly changed after HTO (P < .01). The HDA of the medial compartment to the total HDA ratio decreased from 83% to 77%. Paradoxically, the HDA in the most central subregion of the medial compartment increased from 24% to 30%. There were significant differences between MPTA and JLO in patients with and without paradoxical changes in the HDA. MPTA and JLO cutoff values causing paradoxical changes in the HDA were 94° and 4°, respectively. CONCLUSION: There was a paradoxical stress increase in the M4 region at the medial compartment associated with the MPTA and JLO beyond specific thresholds. Therefore, surgical planning should be cautiously performed to prevent overcorrection, which can lead to adverse stress distribution changes.

Elucidation of the association between additional distal femoral resection and extension angle improvement following the actual surgical steps with the Robot-TKA system.
Ryosuke Hishimura, Koji Iwasaki, Yuki Suzuki, Masatake Matsuoka, Tomohiro Onodera, Eiji Kondo, Norimasa Iwasaki
The Knee, 49, 36, 44, 04 Jun. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: This study investigates the association between additional distal femoral resection and improved flexion contracture in total knee arthroplasty (TKA) with a robot-assisted system. Flexion contracture is a common issue in patients with knee osteoarthritis, which causes postoperative complications and functional limitations. This study aims to evaluate the effectiveness of additional bone resection in flexion contracture correction and knee extension angle improvement after the actual surgical steps. METHODS: The study included 11 patients who underwent posterior-stabilized (PS)-type TKA with a robot-assisted system. The surgical technique consisted of precise bone resection and range of motion evaluation using a navigation system. A precut technique was used to facilitate posterior access and remove osteophytes that cause the contracture. The amount of additional distal femoral resection was determined based on the thickness of the insert trial required for achieving full extension. RESULTS: The flexion contracture correction angle and the amount of additional distal femoral resection demonstrated a linear relationship. An average of 2.0° with the standard error (SE) of 0.6° improvement in flexion contracture was observed per 1.0 mm of additional bone resection. The postoperative evaluation demonstrated a significant improvement in knee extension angle, thereby reducing the contracture degree. CONCLUSION: This study was the first to perform the additional distal femoral resection on the living knee, which closely replicates the actual surgical steps. The current study revealed that an additional 1.0 mm of distal femoral resection in PS-type TKA improves knee extension angle by 2.0° (SE 0.6°) within an additional resection range of 1.0 mm to 3.3 mm.

Atypical lipomatous tumor/well differentiated liposarcomaの脱分化率の検討 米国SEERデータベースを用いた研究
松岡 正剛, 小野寺 智洋, 福田 龍一, 岩崎 浩司, 濱崎 雅成, 江畑 拓, 細川 吉暁, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 98, 6, S1500, S1500, (公社)日本整形外科学会, Jun. 2024
Japanese

軟部腫瘍診療ガイドラインを用いた対話型オープンAIによる診療支援ツールとしての可能性
松岡 正剛, 小野寺 智洋, 福田 龍一, 岩崎 浩司, 濱崎 雅成, 江畑 拓, 細川 吉暁, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 98, 6, S1533, S1533, (公社)日本整形外科学会, Jun. 2024
Japanese

Ultra-rare sarcomaの臨床的特徴 米国SEERデータベースを用いた研究
福田 龍一, 松岡 正剛, 小野寺 智洋, 岩崎 浩司, 江畑 拓, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 98, 6, S1617, S1617, (公社)日本整形外科学会, Jun. 2024
Japanese

四肢原発非円形細胞肉腫において治療開始までの期間が生存に与える影響 米国SEERデータベースを用いた研究
高橋 桜子, 松岡 正剛, 小野寺 智洋, 岩崎 浩司, 濱崎 雅成, 江畑 拓, 細川 吉暁, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 98, 6, S1619, S1619, (公社)日本整形外科学会, Jun. 2024
Japanese

総腓骨神経麻痺を契機に診断された膝外側半月板嚢腫の1例
奥村 眞子, 松岡 正剛, 小野寺 智洋, 岩崎 浩司, 宮石 陸, 細川 吉暁, 濱崎 雅成, 江畑 拓, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 98, 6, S1664, S1664, (公社)日本整形外科学会, Jun. 2024
Japanese

ヒト変形性膝関節症血清における新規N型糖鎖バイオマーカーの網羅的解析とその臨床的意義　　　　　　　　　　　　　　　
小野寺 智洋, 宝満 健太郎, 花松 久寿, 古川 潤一, 岩崎 浩司, 松岡 正剛, 濱崎 雅成, 江畑 拓, 細川 吉暁, 近藤 英司, 岩崎 倫政
日本関節病学会誌, 43, 2, 175, 175, (一社)日本関節病学会, Jun. 2024
Japanese

同位体顕微鏡による関節軟骨内水動態の組織学的評価　　　　　　　　　　　　　　　
松ヶ崎 圭純, 小野寺 智洋, 宝満 健太郎, 亀田 浩之, 工藤 與亮, 坂本 直哉, 細川 吉暁, 松岡 正剛, 福田 龍一, 坂井 裕子, 劉 越, 岩崎 倫政
日本関節病学会誌, 43, 2, 176, 176, (一社)日本関節病学会, Jun. 2024
Japanese

Analysis of foot-originating malignant bone tumors: Epidemiology, characteristics, and survival outcomes.
Masatake Matsuoka, Tomohiro Onodera, Koji Iwasaki, Masanari Hamasaki, Taku Ebata, Yoshiaki Hosokawa, Ryuichi Fukuda, Eiji Kondo, Norimasa Iwasaki
Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons, 29 May 2024, [International Magazine]
English, Scientific journal, BACKGROUND: The study examines the characteristics and outcomes of foot-originating malignant bone tumors via Surveillance Epidemiology and End Results (SEER) database analysis. METHODS: A retrospective review of 14,695 malignant bone tumor cases from 2000 to 2019 was conducted. RESULTS: Of the eligible cases, 147 (2.3 %) were foot-origin tumors, typically smaller and more commonly treated with surgery than those in other locations. These tumors were more frequently treated with surgical resection, with a higher proportion undergoing amputation. In contrast, foot-origin tumors were less often managed with chemotherapy and radiation. Foot-origin tumors exhibited higher survival rates compared to non-foot-origin tumors as shown in univariate analysis, although multivariate analysis did not reflect significant differences. CONCLUSION: Foot-originating malignant bone tumors tend to be smaller and are frequently surgically treated, correlating with favorable survival outcomes. These findings point to early detection as a potential factor in the improved survival rates, not necessarily the tumor's origin.

Glycosphingolipids in Osteoarthritis and Cartilage-Regeneration Therapy: Mechanisms and Therapeutic Prospects Based on a Narrative Review of the Literature.
Kentaro Homan, Tomohiro Onodera, Masatake Matsuoka, Norimasa Iwasaki
International journal of molecular sciences, 25, 9, 30 Apr. 2024, [International Magazine]
English, Scientific journal, Glycosphingolipids (GSLs), a subtype of glycolipids containing sphingosine, are critical components of vertebrate plasma membranes, playing a pivotal role in cellular signaling and interactions. In human articular cartilage in osteoarthritis (OA), GSL expression is known notably to decrease. This review focuses on the roles of gangliosides, a specific type of GSL, in cartilage degeneration and regeneration, emphasizing their regulatory function in signal transduction. The expression of gangliosides, whether endogenous or augmented exogenously, is regulated at the enzymatic level, targeting specific glycosyltransferases. This regulation has significant implications for the composition of cell-surface gangliosides and their impact on signal transduction in chondrocytes and progenitor cells. Different levels of ganglioside expression can influence signaling pathways in various ways, potentially affecting cell properties, including malignancy. Moreover, gene manipulations against gangliosides have been shown to regulate cartilage metabolisms and chondrocyte differentiation in vivo and in vitro. This review highlights the potential of targeting gangliosides in the development of therapeutic strategies for osteoarthritis and cartilage injury and addresses promising directions for future research and treatment.

The alterations in nerve growth factor concentration in plasma and synovial fluid before and after total knee arthroplasty.
Tomohiro Onodera, Koji Iwasaki, Masatake Matsuoka, Yasuhide Morioka, Shinji Matsubara, Eiji Kondo, Norimasa Iwasaki
Scientific reports, 14, 1, 8943, 8943, 18 Apr. 2024, [International Magazine]
English, Scientific journal, Total knee arthroplasty (TKA) is an effective procedure for pain relief; however, the emergence of postsurgical pain remains a concern. In this study, we investigated the production of nerve growth factor (NGF) and mediators that affect NGF production and their function in the synovial fluid and plasma after TKA. This study included 19 patients (20 knees) who had rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and knee osteoarthritis (OA) who underwent TKA, categorized into OA and non-OA groups. The levels of NGF, inflammatory cytokines, and lipid mediators were analyzed before and after surgery. The intraoperative synovial fluid NGF concentration was more than seven times higher in the non-OA group than in the OA group. The intra-articular NGF levels increased significantly by more than threefold postoperatively in the OA group but not in the non-OA group. Moreover, the levels of inflammatory cytokines and lipid mediators were increased in the synovial fluid of both groups. The intra-articular cytokines or NGF concentrations positively correlated with postoperative pain. Targeted NGF control has the potential to alleviate postsurgical pain in TKA, especially in patients with OA, emphasizing the importance of understanding NGF dynamics under different knee conditions.

Surgical Resection of Primary Tumor for Bone Metastatic Breast Cancer Patients at Initial Presentation.
Nayu Kitsuya, Masatake Matsuoka, Tomohiro Onodera, Isao Yokota, Koji Iwasaki, Yuki Suzuki, Masanari Hamasaki, Eiji Kondo, Norimasa Iwasaki
Anticancer research, 44, 4, 1591, 1601, Apr. 2024, [International Magazine]
English, Scientific journal, BACKGROUND/AIM: The purpose of this study was to investigate whether primary tumor resection in patients with bone metastatic breast cancer has an impact on survival using the Surveillance, Epidemiology, and End Results database, considering subtype classification. PATIENTS AND METHODS: We included all female patients with bone metastatic breast cancer at initial presentation between 2010 and 2016 with known hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) statuses. Cases showing unknown cause of death or unknown HR/HER2 status were excluded. Survival analysis was performed using Cox proportional hazards modeling to calculate hazard ratios (HZR). RESULTS: Of the 13,450 patients included in this study, 2,073 patients were HR+/HER2+, 8,597 patients were HR+/HER2-, 797 patients were HR-/HER2+, and 1,182 patients were HR-/HER2- (triple-negative). Five-year overall survival (OS) rate was 34.5% in HR+/HER2+, 26.0% in HR+/HER2-, 29.2% in HR-/HER2+ and 8.0% in triple-negative. Triple-negative patients showed the worsen OS [HR+/HER2+: HZR=2.1, 95% confidence interval (CI)=1.9-2.3; HR+/HER2-: HZR= 2.4, 95%CI=2.2-2.6; HR-/HER2+: HZR=1.5, 95%CI=1.3-1.6]. After excluding patients who died within six months, primary tumor resection prolonged survival in each subtype classification except HR-/HER2+. CONCLUSION: Patients with triple-negative bone metastatic breast cancer showed unfavorable survival. Primary tumor resection prolonged survival in each subtype except for HR-/HER2+.

Bone Density Distribution Pattern in the Lateral Wall of the Femoral Intercondylar Notch: Implications for the Direct Insertion of the Femoral ACL Attachment.
Yutaro Sugawara, Koji Iwasaki, Yuki Suzuki, Ryosuke Hishimura, Shinji Matsubara, Masatake Matsuoka, Tomohiro Onodera, Eiji Kondo, Norimasa Iwasaki
Orthopaedic journal of sports medicine, 12, 4, 23259671241236807, 23259671241236807, Apr. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: The ideal position of the femoral bone tunnel in the anterior cruciate ligament (ACL) is controversial. The functional importance of the ACL fiber varies depending on where it is attached to the femur. Functionally important fibers can cause high mechanical stress on the bone, and the Wolff law predicts that bone mineral density will increase at high mechanical stress sites. PURPOSE/HYPOTHESIS: The purpose of this study was to use computed tomography imaging to determine the distribution pattern of bone density in the lateral intercondylar wall. It was hypothesized that the high-density area (HDA) of the lateral intercondylar wall would reflect the functional insertion of the ACL as reported in previous anatomic studies. STUDY DESIGN: Descriptive epidemiology study. METHODS: Data from 39 knees without ACL injuries were retrospectively collected. The HDA of the lateral intercondylar wall was defined as the region containing the top 10% of the radiodensity values. The shape of the HDA was approximated as an ellipse, and the quadrant method was used to determine the center of the ellipse. The association between the ratio of the minor axis to the major axis of the ellipse and background characteristics was investigated. RESULTS: According to the quadrant method, the center of the HDA ellipse was 33.6% in the deep-shallow direction and 23.4% in the high-low direction. The center of the ellipse was comparable to the anatomic center of the ACL footprint, as previously reported. The ratio of the minor axis to the major axis of the ellipse was 0.58 (95% CI, 0.54-0.62). There was a significant negative correlation between the ratio of the minor axis to the major axis of the HDA ellipse and the posterior tibial slope (r = -0.38, P = .02). CONCLUSION: The center of the HDA ellipse was found to be similar to the anatomic center of the ACL footprint. Considering the mechanical stress responses in bone, the HDA of the lateral intercondylar wall has the potential to represent the ACL insertion, especially functional insertion.

Articular cartilage corefucosylation regulates tissue resilience in osteoarthritis.
Kentaro Homan, Tomohiro Onodera, Hisatoshi Hanamatsu, Jun-Ichi Furukawa, Daisuke Momma, Masatake Matsuoka, Norimasa Iwasaki
eLife, 12, 11 Mar. 2024, [International Magazine]
English, Scientific journal, This study aimed to investigate the glycan structural changes that occur before histological degeneration in osteoarthritis (OA) and to determine the mechanism by which these glycan conformational changes affect cartilage degeneration. An OA model was established in rabbits using mannosidase injection, which reduced high-mannose type N-glycans and led to cartilage degeneration. Further analysis of glycome in human OA cartilage identified specific corefucosylated N-glycan expression patterns. Inhibition of N-glycan corefucosylation in mice resulted in unrecoverable cartilage degeneration, while cartilage-specific blocking of corefucosylation led to accelerated development of aging-associated and instability-induced OA models. We conclude that α1,6 fucosyltransferase is required postnatally to prevent preosteoarthritic deterioration of articular cartilage. These findings provide a novel definition of early OA and identify glyco-phenotypes of OA cartilage, which may distinguish individuals at higher risk of progression.

遠隔転移を有する原発性悪性骨腫瘍において原発巣切除は生存を改善するか? 米国SEERデータベースを用いた研究
福田 龍一, 松岡 正剛, 小野寺 智洋, 岩崎 浩司, 江畑 拓, 濱崎 雅成, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 98, 2, S94, S94, (公社)日本整形外科学会, Mar. 2024
Japanese

足部に発生した原発性悪性骨腫瘍の生存解析 SEER databaseを用いた研究
松岡 正剛, 小野寺 智洋, 岩崎 浩司, 濱崎 雅成, 江畑 拓, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 98, 2, S277, S277, (公社)日本整形外科学会, Mar. 2024
Japanese

80歳以上高齢者に発生した四肢発生軟部肉腫における放射線照射
松岡 正剛, 小野寺 智洋, 岩崎 浩司, 濱崎 雅成, 江畑 拓, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 98, 2, S415, S415, (公社)日本整形外科学会, Mar. 2024
Japanese

女性乳がんサブタイプ分類が骨転移症例における生存へ与える影響 米国SEERデータベースを用いた研究
松岡 正剛, 木津谷 菜悠, 小野寺 智洋, 横田 勲, 岩崎 浩司, 濱崎 雅成, 江畑 拓, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 98, 2, S417, S417, (公社)日本整形外科学会, Mar. 2024
Japanese

コラーゲン膜を用いた自家培養軟骨移植の臨床成績 骨膜被覆との比較
甲斐原 拓真, 近藤 英司, 濱崎 雅成, 江畑 拓, 原 健人, 岩崎 浩司, 松岡 正剛, 小野寺 智洋, 門間 太輔, 岩崎 倫政
日本整形外科学会雑誌, 98, 2, S448, S448, (公社)日本整形外科学会, Mar. 2024
Japanese

逆V字型高位脛骨骨切り術後のスポーツ復帰
江畑 拓, 近藤 英司, 濱崎 雅成, 原 健人, 岩崎 浩司, 松岡 正剛, 小野寺 智洋, 岩崎 倫政
日本整形外科学会雑誌, 98, 3, S818, S818, (公社)日本整形外科学会, Mar. 2024
Japanese

内側閉鎖式大腿骨遠位内反骨切り術が膝蓋大腿関節の応力分布に与える影響 CT osteoabsorptiometry法を用いた検討
濱崎 雅成, 近藤 英司, 江畑 拓, 松岡 正剛, 岩崎 浩司, 小野寺 智洋, 井上 雅之, 安田 和則, 八木 知徳, 岩崎 倫政
日本整形外科学会雑誌, 98, 3, S911, S911, (公社)日本整形外科学会, Mar. 2024
Japanese

高位脛骨骨切り術前後の膝関節矢状面における応力分布の変化についての検討
藤江 裕貴, 岩崎 浩司, 江畑 拓, 濱崎 雅成, 松岡 正剛, 小野寺 智洋, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 98, 3, S913, S913, (公社)日本整形外科学会, Mar. 2024
Japanese

膝軟骨下骨脆弱性骨折の骨髄浮腫面積が高位脛骨骨切り術後の臨床成績に与える影響
原 健人, 近藤 英司, 薮内 康史, 江畑 拓, 濱崎 雅成, 松岡 正剛, 岩崎 浩司, 小野寺 智洋, 八木 知徳, 岩崎 倫政
日本整形外科学会雑誌, 98, 3, S959, S959, (公社)日本整形外科学会, Mar. 2024
Japanese

脛骨関節面の軟骨下骨の骨密度分布に与える半月板の影響の検討に適した半月板評価法の検討
岩崎 浩司, 佐藤 知哉, 江畑 拓, 濱崎 雅成, 原 健人, 松岡 正剛, 小野寺 智洋, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 98, 3, S1097, S1097, (公社)日本整形外科学会, Mar. 2024
Japanese

The Influence of Patello-Femoral Overstuffing After Modular Unlinked Bicompartmental Knee Arthroplasty (BiKA) for Medial Tibio-Femoral and Patello-Femoral Osteoarthritis of the Knee.
Rikiya Baba, Yasumitsu Ohkoshi, Tatsunori Maeda, Ko Suzuki, Akane Iwadate, Koji Iwasaki, Tomohiro Onodera, Eiji Kondo, Norimasa Iwasaki
The Journal of arthroplasty, 39, 3, 638, 644, Mar. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: The factors affecting results after bicompartmental knee arthroplasty (BiKA) have not been fully elucidated. This major ligament-preserving procedure may be more susceptible to overstuffing of the patello-femoral (PF) joint than the major ligament-sacrificing total knee arthroplasty. Currently, we investigated the effect of PF overstuffing after BiKA on its clinical outcome. METHODS: There were 71 patients (74 knees) who underwent modular unlinked BiKA at our clinic who had a follow-up of 5 to 9 years. Final follow-up results were assessed by evaluating knee range of motion, the 2011 Knee Society Score (2011KSS), Japanese Knee Osteoarthritis Measure, and radiological findings. The degree of postoperative PF overstuffing was evaluated by computed tomography and magnetic resonance images for 55 knees, and the correlation between the degree of overstuffing and postoperative clinical results were examined. RESULTS: Overall clinical results improved significantly after surgery without any revision cases. The X-ray measurements showed the improved coronal alignments and the appropriate implant installation angles. Higher degree of postoperative PF overstuffing caused by insufficient amount of osteotomy on the anterior surface of the femur correlated with worse postoperative total 2011KSS at 2 years after surgery (Spearman's rank correlation coefficient (rs) = -0.387, P = .004), as opposed to no correlation at the time of the final follow-up (Spearman's rank correlation coefficient = 0.068, P = .623). CONCLUSION: Modular unlinked BiKA provided patients with a high level of satisfaction and functional improvement over 5 to 9 years postoperatively. However, because PF overstuffing affects initial patient satisfaction, the amount of osteotomy should be determined carefully during the surgery.

Simultaneous medial closing wedge distal femoral varus osteotomy and double-bundle anterior cruciate ligament reconstruction in the symptomatic femoral valgus deformity: A case report.
Masatake Matsuoka, Eiji Kondo, Koji Iwasaki, Tomohiro Onodera, Ryuichi Nakamura, Hiroshi Nakayama, Takenori Akiyama, Daisuke Momma, Norimasa Iwasaki
Joint diseases and related surgery, 35, 2, 422, 432, 13 Feb. 2024, [International Magazine]
English, Scientific journal, Distal femoral varus osteotomy (DFVO) is a widely recognized surgical procedure used to address valgus malalignment in patients with knee joint disorders. However, it still remains unclear whether anterior cruciate ligament (ACL) reconstruction can be performed in a single procedure along with DFVO. Herein, we present a 73-year-old female patient who developed lateral osteoarthritis of the knee with valgus alignment due to chronic ACL deficiency following a twisting injury during skiing. She was physiologically very active, and strongly demanded to return to sports. We performed a combined procedure involving a medial closing wedge DFVO using an anatomical locking plate, along with double-bundle ACL reconstruction. The postoperative radiograph confirmed successful correction of knee alignment, specifically achieving varus alignment with precise conformance of the anatomical plate to the medial contour of the distal femur following the osteotomy. The patient resumed her previous sports activities without experiencing knee pain. The operated knee demonstrated restored anterior stability, as indicated by negative Lachman test results, and regained full range of motion. Both the Knee Injury and Osteoarthritis Outcome Score and the 2011 Knee Society score demonstrated continuous postoperative improvements over the three-year follow-up period, indicating positive functional outcomes and joint preservation. To the best of our knowledge, this is the first case of medial closing wedge DFVO with anatomic double-bundle ACL reconstruction in the symptomatic femoral valgus deformity with chronic ACL deficiency in the literature.

Bone metastatic cancer of unknown primary at initial presentation.
Masatake Matsuoka, Tomohiro Onodera, Isao Yokota, Koji Iwasaki, Yuki Suzuki, Hamasaki Masanari, Eiji Kondo, Norimasa Iwasaki
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 26, 2, 461, 467, Feb. 2024, [International Magazine]
English, Scientific journal, INTRODUCTION: Cancer of unknown primary (CUP) is a challenging malignancy. The purpose of this study was to investigate the clinical characteristics and prognosis of bone metastatic CUP using the population-based Surveillance, Epidemiology, and End Results (SEER) database. METHODS: From the SEER database, we identified 1908 patients with bone metastatic CUP at initial presentation between 2010 and 2018. Histology was subdivided following International Classification of Diseases for Oncology codes as Adenocarcinoma, Squamous cell, Neuroendocrine, or Carcinoma not otherwise specified (NOS). Cox proportional hazard modeling was applied using factors of age, sex, ethnicity, histological subtype, and therapeutic intervention. RESULTS: Among the 1908 patients, histology was Neuroendocrine in 240 patients, Squamous cell in 201 patients, Adenocarcinoma in 810 patients and NOS in 657 patients. In each subtype, patients tended to be predominantly male and white. Chemotherapy was introduced for 28% of patients and radiation for 34% in the entire cohort. Survival in patients with bone metastatic CUP was unfavorable, with a median survival of 2 months. Among the histological subtypes, Adenocarcinoma showed shorter survival than the other groups. In addition, treatment interventions such as chemotherapy and radiation therapy prolonged survival, particularly for Squamous cell, Adenocarcinoma and NOS, but not for Neuroendocrine. DISCUSSION: Bone metastatic CUP showed extremely poor prognosis, but treatment interventions such as chemotherapy and radiation generally offered survival benefits. Further randomized clinical research is needed to confirm the present results.

同位体標識水による関節軟骨内水動態の可視化
松ヶ崎 圭純, 小野寺 智洋, 宝満 健太郎, 細川 吉暁, 松岡 正剛, 福田 龍一, 坂井 裕子, 劉 越, 岩崎 倫政, 亀田 浩之, 工藤 與亮, 坂本 直哉
北海道整形災害外科学会雑誌, 66, 143rd suppl, 83, 83, 北海道整形災害外科学会, 2024
Japanese

継代細胞における糖鎖シグネチャーの解明
宝満 健太郎, 徳廣 泰貴, 小野寺 智洋, 江畑 拓, Alaa Terkawi, 松岡 正剛, 花松 久寿, 古川 潤一, 角家 健, 岩崎 倫政
北海道整形災害外科学会雑誌, 66, 143rd suppl, 85, 85, 北海道整形災害外科学会, 2024
Japanese

Magnetic Resonance Water Tracer Imaging Using 17 O-Labeled Water.
Hiroyuki Kameda, Naoya Kinota, Daisuke Kato, Takaaki Fujii, Taisuke Harada, Yuji Komaki, Hiroyuki Sugimori, Tomohiro Onodera, Moyoko Tomiyasu, Takayuki Obata, Kohsuke Kudo
Investigative radiology, 59, 1, 92, 103, 01 Jan. 2024, [International Magazine]
English, Scientific journal, Magnetic resonance imaging (MRI) is a crucial imaging technique for visualizing water in living organisms. Besides proton MRI, which is widely available and enables direct visualization of intrinsic water distribution and dynamics in various environments, MR-WTI (MR water tracer imaging) using 17 O-labeled water has been developed, benefiting from the many advancements in MRI software and hardware that have substantially improved the signal-to-noise ratio and made possible faster imaging. This cutting-edge technique allows the generation of novel and valuable images for clinical use. This review elucidates the studies related to MRI water tracer techniques centered around 17 O-labeled water, explaining the fundamental principles of imaging and providing clinical application examples. Anticipating continued progress in studies involving isotope-labeled water, this review is expected to contribute to elucidating the pathophysiology of various diseases related to water dynamics abnormalities and establishing novel imaging diagnostic methods for associated diseases.

Atelocollagen-associated autologous chondrocyte implantation for the repair of large cartilage defects of the knee: Results at three to seven years.
Takuma Kaibara, Eiji Kondo, Masatake Matsuoka, Koji Iwasaki, Tomohiro Onodera, Keita Sakamoto, Yoshitaka Oda, Zen-Ichi Tanei, Daisuke Momma, Shinya Tanaka, Norimasa Iwasaki
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 29, 1, 207, 216, Jan. 2024, [Domestic magazines]
English, Scientific journal, BACKGROUND: Recently, various types of engineered autologous chondrocyte implantation (ACI) have been developed. Atelocollagen-associated ACI (A-ACI) is the only ACI procedure covered by Japanese Health Insurance since 2013. The indications of the A-ACI are traumatic cartilage defects and osteochondral dissecans (OCD) for knee joints. PURPOSE: To evaluate midterm clinical results after A-ACI for the treatment for full-thickness cartilage defects of the knee. METHODS: Thirteen consecutive patients who underwent A-ACI between 2014 and 2018 had been prospectively enrolled in this study. There were 11 men and 2 women with a mean age of 34 years at the time of surgery. The causes of the cartilage defect were trauma in 10 knees and OCD in 3 knees. The total number of lesions was 15, which were comprised of the medial femoral condyle in 5 knees, the lateral femoral condyle in 5 knees, and the femoral trochlea in 5 knees. The mean size of the lesion was 5.3 cm2. Each knee was clinically and radiologically evaluated preoperatively and postoperatively. RESULTS: The mean Lysholm score improved significantly from 74.0 points to 94.0 points (p = 0.008) and each subscale in Knee injury and Osteoarthritis Outcome Score improved significantly (p < 0.001) at the mean final follow-up period of 51 months (range, 36-84 months). The magnetic resonance observation of cartilage repair tissue 2.0 score at the mean follow-up of 38 months was significantly higher than that at 2 months postoperatively (p = 0.014). According to the International Cartilage Repair Society (ICRS) grading scale, 3 knees were graded as normal, 3 knees as nearly normal, and 1 knee as severely abnormal in second-look arthroscopic evaluation at a mean of 22 months (range, 8-41 months) after A-ACI. CONCLUSION: The present study showed a significant subjective and objective clinical improvement in the A-ACI for large cartilage defects of the knee at a mean follow-up of 51 months (range, 36-84 months).

Assessing knee joint biomechanics and trunk posture according to medial osteoarthritis severity.
Yuki Suzuki, Yasumitsu Ohkoshi, Kensaku Kawakami, Kenta Shimizu, Shuya Chida, Kengo Ukishiro, Tomohiro Onodera, Koji Iwasaki, Tatsunori Maeda, Sho'ji Suzuki, Eiji Kondo, Norimasa Iwasaki
Scientific reports, 13, 1, 19186, 19186, 06 Nov. 2023, [International Magazine]
English, Scientific journal, During progression of knee osteoarthritis (OA), gait biomechanics changes three-dimensionally; however, its characteristics and trunk posture according to OA severity remain unknown. The present study investigated three-dimensional knee joint biomechanics and trunk posture according to knee OA severity. Overall, 75 patients (93 knees) with medial knee OA [Kellgren-Lawrence grade ≥ 2, grade 2: 20 patients with 24 knees (mean 60.0 years old); grade 3: 25 with 28 knees (mean 62.0 years old); grade 4: 30 with 41 knees (mean 67.9 years old)] and 14 healthy controls (23 knees, mean 63.6 years old) underwent gait analysis using an optical motion capture system and point cluster technique. In grade 2 knee OA, the relative contribution of the knee adduction moment (KAM) increased significantly (P < 0.05), and that of the knee flexion moment decreased (P < 0.05) prior to significant progression of varus knee deformity. Grade 3 knee OA showed significant exacerbation of varus knee deformity (P < 0.01) and KAM increase (P < 0.001). The maximum knee extension angle decreased (P < 0.05) and trunk flexion increased during gait in grade 4 knee OA (P < 0.001). Our study clarified the kinematics and kinetics of medial knee OA with trunk flexion according to severity. Kinetic conversion occurred in grade 2 knees prior to progression of varus deformities, knee flexion contractures, and sagittal imbalance during gait in patients with severe knee OA.

Effect of Patient Age on Clinical and Radiological Outcomes After Medial Open-Wedge High Tibial Osteotomy: A Comparative Study With 344 Knees.
Koji Yabuuchi, Eiji Kondo, Takuma Kaibara, Jun Onodera, Koji Iwasaki, Masatake Matsuoka, Tomohiro Onodera, Norimasa Iwasaki, Tomonori Yagi, Kazunori Yasuda
Orthopaedic journal of sports medicine, 11, 10, 23259671231200227, 23259671231200227, Oct. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: There exists some controversy regarding whether patient age is a predictive factor for outcomes after high tibial osteotomy (HTO). PURPOSE/HYPOTHESIS: The purpose of this study was to evaluate whether patient age affects clinical and radiological outcomes after medial open-wedge HTO (OWHTO) in a large population with a wider age range than previous studies. It was hypothesized that there would be no differences in outcomes when compared across age-groups. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: A retrospective comparative study was conducted using 344 patients (303 knees) who underwent OWHTO from 2009 to 2018. These patients were divided into 3 groups based on age at the time of surgery: ≥55 years (group Y: 76 knees in 57 patients), 56 to 64 years (group M: 129 knees in 120 patients), and ≤65 years (group O: 139 knees in 126 patients). Clinical and radiological evaluations were performed immediately before surgery and at the final follow-up period, at a mean of 5.1 years (range, 3-11 years). Comparisons among the 3 groups were conducted with 1-way analysis of variance for continuous variables. When a significant result was obtained, a post hoc test with Bonferroni correction was conducted for multiple comparisons. RESULTS: In clinical evaluations, there were no significant differences among the 3 groups either preoperatively or postoperatively concerning the Japanese Orthopaedic Association score, the Lysholm score, or the Knee injury and Osteoarthritis Outcome Score (KOOS), with the exception of the preoperative KOOS Symptoms subscale, which was significantly higher in group Y versus group O (48.9 ± 18.7 vs 58.7 ± 15.4, respectively; P = .011). The Tegner activity score was significantly different among the groups, both preoperatively and postoperatively (P < .001 for both). There was no significant difference in the occurrence of complications or the survival rate at final follow-up among the 3 groups. CONCLUSION: The study findings suggest that patient age does not affect clinical and radiological outcomes after OWHTO.

Targeted next-generation sequencing for detection of PIK3CA mutations in archival tissues from patients with Klippel-Trenaunay syndrome in an Asian population : List the full names and institutional addresses for all authors.
Yuki Sasaki, Kosuke Ishikawa, Kanako C Hatanaka, Yumiko Oyamada, Yusuke Sakuhara, Tadashi Shimizu, Tatsuro Saito, Naoki Murao, Tomohiro Onodera, Takahiro Miura, Taku Maeda, Emi Funayama, Yutaka Hatanaka, Yuhei Yamamoto, Satoru Sasaki
Orphanet journal of rare diseases, 18, 1, 270, 270, 04 Sep. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: Klippel-Trenaunay syndrome (KTS) is a rare slow-flow combined vascular malformation with limb hypertrophy. KTS is thought to lie on the PIK3CA-related overgrowth spectrum, but reports are limited. PIK3CA encodes p110α, a catalytic subunit of phosphatidylinositol 3-kinase (PI3K) that plays an essential role in the PI3K/AKT/mammalian target of rapamycin (mTOR) signaling pathway. We aimed to demonstrate the clinical utility of targeted next-generation sequencing (NGS) in identifying PIK3CA mosaicism in archival formalin-fixed paraffin-embedded (FFPE) tissues from patients with KTS. RESULTS: Participants were 9 female and 5 male patients with KTS diagnosed as capillaro-venous malformation (CVM) or capillaro-lymphatico-venous malformation (CLVM). Median age at resection was 14 years (range, 5-57 years). Median archival period before DNA extraction from FFPE tissues was 5.4 years (range, 3-7 years). NGS-based sequencing of PIK3CA achieved an amplicon mean coverage of 119,000x. PIK3CA missense mutations were found in 12 of 14 patients (85.7%; 6/8 CVM and 6/6 CLVM), with 8 patients showing the hotspot variants E542K, E545K, H1047R, and H1047L. The non-hotspot PIK3CA variants C420R, Q546K, and Q546R were identified in 4 patients. Overall, the mean variant allele frequency for identified PIK3CA variants was 6.9% (range, 1.6-17.4%). All patients with geographic capillary malformation, histopathological lymphatic malformation or macrodactyly of the foot had PIK3CA variants. No genotype-phenotype association between hotspot and non-hotspot PIK3CA variants was found. Histologically, the vessels and adipose tissues of the lesions showed phosphorylation of the proteins in the PI3K/AKT/mTOR signaling pathway, including p-AKT, p-mTOR, and p-4EBP1. CONCLUSIONS: The PI3K/AKT/mTOR pathway in mesenchymal tissues was activated in patients with KTS. Amplicon-based targeted NGS could identify low-level mosaicism from low-input DNA extracted from FFPE tissues, potentially providing a diagnostic option for personalized medicine with inhibitors of the PI3K/AKT/mTOR signaling pathway.

アテロコラーゲンを用いた自家培養軟骨移植後に軟骨下骨嚢胞を生じた1例
甲斐原 拓真, 近藤 英司, 濱崎 雅成, 鈴木 裕貴, 岩崎 浩司, 松岡 正剛, 小野寺 智洋, 種井 善一, 田中 伸哉, 岩崎 倫政
東日本整形災害外科学会雑誌, 35, 3, 361, 361, 東日本整形災害外科学会, Aug. 2023
Japanese

Single-step ultra-purified alginate gel implantation in patients with knee chondral defects.
Tomohiro Onodera, Daisuke Momma, Masatake Matsuoka, Eiji Kondo, Koji Suzuki, Masayuki Inoue, Masaki Higano, Norimasa Iwasaki
The bone & joint journal, 105-B, 8, 880, 887, 01 Aug. 2023, [International Magazine]
English, Scientific journal, AIMS: Implantation of ultra-purified alginate (UPAL) gel is safe and effective in animal osteochondral defect models. This study aimed to examine the applicability of UPAL gel implantation to acellular therapy in humans with cartilage injury. METHODS: A total of 12 patients (12 knees) with symptomatic, post-traumatic, full-thickness cartilage lesions (1.0 to 4.0 cm2) were included in this study. UPAL gel was implanted into chondral defects after performing bone marrow stimulation technique, and assessed for up to three years postoperatively. The primary outcomes were the feasibility and safety of the procedure. The secondary outcomes were self-assessed clinical scores, arthroscopic scores, tissue biopsies, and MRI-based estimations. RESULTS: No obvious adverse events related to UPAL gel implantation were observed. Self-assessed clinical scores, including pain, symptoms, activities of daily living, sports activity, and quality of life, were improved significantly at three years after surgery. Defect filling was confirmed using second-look arthroscopy at 72 weeks. Significantly improved MRI scores were observed from 12 to 144 weeks postoperatively. Histological examination of biopsy specimens obtained at 72 weeks after implantation revealed an extracellular matrix rich in glycosaminoglycan and type II collagen in the reparative tissue. Histological assessment yielded a mean overall International Cartilage Regeneration & Joint Preservation Society II score of 69.1 points (SD 10.4; 50 to 80). CONCLUSION: This study provides evidence supporting the safety of acellular UPAL gel implantation in facilitating cartilage repair. Despite being a single-arm study, it demonstrated the efficacy of UPAL gel implantation, suggesting it is an easy-to-use, one-step method of cartilage tissue repair circumventing the need to harvest donor cells.

アテロコラーゲンを用いた自家培養軟骨移植後に軟骨下骨嚢胞を生じた1例　　　　　　　　　　　　　　　
甲斐原 拓真, 近藤 英司, 濱崎 雅成, 鈴木 裕貴, 岩崎 浩司, 松岡 正剛, 小野寺 智洋, 種井 善一, 田中 伸哉, 岩崎 倫政
東日本整形災害外科学会雑誌, 35, 3, 361, 361, 東日本整形災害外科学会, Aug. 2023
Japanese

Noncanonical Pyroptosis Triggered by Macrophage-Derived Extracellular Vesicles in Chondrocytes Leading to Cartilage Catabolism in Osteoarthritis.
Taku Ebata, Mohamad Alaa Terkawi, Keita Kitahara, Shunichi Yokota, Junki Shiota, Yoshio Nishida, Gen Matsumae, Hend Alhasan, Masanari Hamasaki, Kazutoshi Hontani, Tomohiro Shimizu, Daisuke Takahashi, Tsutomu Endo, Tomohiro Onodera, Ken Kadoya, Norimasa Iwasaki
Arthritis & rheumatology (Hoboken, N.J.), 75, 8, 1358, 1369, Aug. 2023, [International Magazine]
English, Scientific journal, OBJECTIVES: The severity of osteoarthritis and cartilage degeneration are highly correlated with the development of synovitis, which is mediated by the activity of inflammatory macrophages. A better understanding of intercellular communication between inflammatory macrophages and chondrocytes should aid in the discovery of novel therapeutic targets. Here, we explored the pathological role of inflammatory macrophage extracellular vesicles in cartilage degeneration. METHODS: Macrophages were stimulated by treatment with bacterial lipopolysaccharides to mimic the state of inflammatory macrophages and the resulting extracellular vesicles were harvested for chondrocyte stimulation in vitro and intraarticular injection in a mouse model. The stimulated chondrocytes were further subjected to RNA-seq analysis and other functional assays. The action of caspase-11 was disrupted in vitro using a specific siRNA or wedelolactone, and in experimental OA-murine models by the intraarticular injection of wedelolactone. RESULTS: Stimulated chondrocytes exhibited a significant elevation in the expression of chondrocyte catabolic factors. Consistent with these results, RNA-seq analyses of stimulated chondrocytes indicated that upregulated genes are mainly categorized into apoptotic process and TNF-signaling pathway which suggests the induction of apoptotic process. Moreover, these chondrocytes exhibited a significant elevation in the expression of pyroptosis-related molecules that were correlated with the expression of chondrocyte catabolic factors. The disruption of caspase-11 significantly alleviated pyroptotic and catabolic processes in stimulated chondrocytes and the pathological changes in collagenase-and joint instability-induced OA models. CONCLUSIONS: Our results provide a new insight into the pathological mechanisms of OA and suggest that non-canonical pyroptosis in chondrocytes represents an attractive therapeutic target for future treatment.

Symptomatic bilateral complete discoid medial menisci of the knee in a child: A case report.
Yuki Suzuki, Eiji Kondo, Takuma Kaibara, Masatake Matsuoka, Ryosuke Hishimura, Koji Iwasaki, Tomohiro Onodera, Daisuke Momma, Shinya Tanaka, Norimasa Iwasaki
Joint diseases and related surgery, 34, 2, 455, 462, 26 Apr. 2023, [International Magazine]
English, Scientific journal, Bilateral complete discoid medial menisci are extremely rare congenital anatomic variants of the knee. Currently, arthroscopic partial meniscectomy with or without peripheral suture repair is performed for symptomatic discoid meniscus. However, most of the outcomes are short-term. In this article, we present a pediatric case of symptomatic bilateral complete discoid medial menisci and highlight the effectiveness of arthroscopic partial meniscectomy with or without peripheral suture on symptomatic complete discoid medial menisci based on 60-month excellent clinical and functional results.

Simultaneous and sialic acid linkage-specific N- and O-linked glycan analysis by ester-to-amide derivatization.
Hisatoshi Hanamatsu, Yoshiaki Miura, Takashi Nishikaze, Ikuko Yokota, Kentaro Homan, Tomohiro Onodera, Yoshihiro Hayakawa, Norimasa Iwasaki, Jun-Ichi Furukawa
Glycoconjugate journal, 40, 2, 259, 267, Apr. 2023, [International Magazine]
English, Scientific journal, Characterization of O-glycans linked to serine or threonine residues in glycoproteins has mostly been achieved using chemical reaction approaches because there are no known O-glycan-specific endoglycosidases. Most O-glycans are modified with sialic acid residues at the non-reducing termini through various linkages. In this study, we developed a novel approach for sialic acid linkage-specific O-linked glycan analysis through lactone-driven ester-to-amide derivatization combined with non-reductive β-elimination in the presence of hydroxylamine. O-glycans released by non-reductive β-elimination were efficiently purified using glycoblotting via chemoselective ligation between carbohydrates and a hydrazide-functionalized polymer, followed by modification of methyl or ethyl ester groups of sialic acid residues on solid-phase. In-solution lactone-driven ester-to-amide derivatization of ethyl-esterified O-glycans was performed, and the resulting sialylated glycan isomers were discriminated by mass spectrometry. In combination with PNGase F digestion, we carried out simultaneous, quantitative, and sialic acid linkage-specific N- and O-linked glycan analyses of a model glycoprotein and human cartilage tissue. This novel glycomic approach will facilitate detailed characterization of biologically relevant sialylated N- and O-glycans on glycoproteins.

Early Changes in Postural Balance Following Inverted V-Shaped High Tibial Osteotomy in Patients With Knee Osteoarthritis.
Kento Sabashi, Takeshi Chiba, Koji Iwasaki, Tomohiro Onodera, Eiji Kondo, Norimasa Iwasaki, Harukazu Tohyama
Journal of applied biomechanics, 39, 2, 124, 129, 01 Apr. 2023, [International Magazine]
English, Scientific journal, Patients with knee osteoarthritis and varus knee deformity have impaired postural balance, resulting in decreased walking performance and an increased risk of falls. This study aimed to investigate the early changes in the postural balance following inverted V-shaped high tibial osteotomy (HTO). Fifteen patients with medial knee osteoarthritis were recruited. Postural balance was assessed using the center-of-pressure (COP) data during single-leg standing before and 6 weeks after inverted V-shaped HTO. The maximum range, mean velocity, and area of COP movements in the anteroposterior and mediolateral directions were analyzed. Preoperative and postoperative visual analog scale for knee pain was assessed. The maximum range of COP in the mediolateral direction decreased (P = .017), whereas the mean velocity of COP in the anteroposterior direction increased 6 weeks postoperatively (P = .011). The visual analog scale score for knee pain significantly improved at 6 weeks postoperatively (P = .006). Valgus correction with inverted V-shaped HTO resulted in improved postural balance in the mediolateral direction and good short-term clinical outcomes early following surgery. Early rehabilitation after inverted V-shaped HTO should focus on postural balance in the anteroposterior direction.

Amputation surgery associated with shortened survival in patients with localized soft tissue sarcoma.
Masatake Matsuoka, Tomohiro Onodera, Isao Yokota, Koji Iwasaki, Ryosuke Hishimura, Yuki Suzuki, Masanari Hamasaki, Akira Iwata, Eiji Kondo, Norimasa Iwasaki
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 29, 2, 637, 645, 15 Mar. 2023, [Domestic magazines]
English, Scientific journal, BACKGROUND: The objectives of this study were to clarify whether localized extremity soft tissue sarcoma (STS) patients who underwent amputation surgery experienced worsened survival and to identify those patients for whom amputation surgery worsened survival. METHODS: Using the Surveillance, Epidemiology, and End Results database, we identified 8897 patients with localized extremity STS between 1983 and 2016. Of these 6431 patients, 733 patients underwent amputation surgery (Amputation group), and 5698 underwent limb-sparing surgery (Limb-sparing group). RESULTS: After adjusting for patient background by propensity score matching, a total of 1346 patients were included. Patients in the Amputation group showed worsened survival (cancer-specific survival (CSS): hazard ratio (HR) = 1.42, 95% confidence interval (CI) 1.15-1.75, overall survival (OS): HR = 1.41, 95%CI 1.20-1.65). In subclass analysis, patients with high-grade STS, spindle cell sarcoma and liposarcoma in the Amputation group showed shortened survival (high-grade-CSS: HR = 1.44, 95%CI 1.16-1.77, OS: HR = 1.38, 95%CI 1.18-1.62; spindle cell sarcoma-CSS: HR = 4.75, 95%CI 1.56-14.4, OS: HR = 2.32, 95%CI 1.45-3.70; liposarcoma-CSS: HR = 2.91, 95%CI 1.54-5.50, OS: HR = 2.32, 95%CI 1.45-3.70). CONCLUSIONS: Survival was shortened in localized extremity STS patients who received amputation surgery.

変形性膝関節症患者における下腿加速度と膝関節の荷重分布との関係 ウェアラブルセンサーを用いて
佐橋 健人, 岩崎 浩司, 安倍 雄一郎, 渡邊 謙太郎, 千徳 風真, 千葉 健, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 遠山 晴一
日本整形外科学会雑誌, 97, 3, S864, S864, (公社)日本整形外科学会, Mar. 2023
Japanese

大腿骨顆間外側壁における骨密度分布 前十字靱帯の大腿骨付着部に関する考察
菅原 悠太郎, 岩崎 浩司, 遠藤 香織, 菱村 亮介, 松原 新史, 松岡 正剛, 門間 太輔, 小野寺 智洋, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 97, 2, S193, S193, (公社)日本整形外科学会, Mar. 2023
Japanese

変形性膝関節症患者における下腿加速度と膝関節の荷重分布との関係 ウェアラブルセンサーを用いて
佐橋 健人, 岩崎 浩司, 安倍 雄一郎, 渡邊 謙太郎, 千徳 風真, 千葉 健, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 遠山 晴一
日本整形外科学会雑誌, 97, 3, S864, S864, (公社)日本整形外科学会, Mar. 2023
Japanese

Higher Association of Pelvis-Knee-Ankle Angle Compared With Hip-Knee-Ankle Angle With Knee Adduction Moment and Patient-Reported Outcomes After High Tibial Osteotomy.
Koji Iwasaki, Yasumitsu Ohkoshi, Yoshiaki Hosokawa, Shuya Chida, Kengo Ukishiro, Kensaku Kawakami, Sho'ji Suzuki, Tatsunori Maeda, Tomohiro Onodera, Eiji Kondo, Norimasa Iwasaki
The American journal of sports medicine, 51, 4, 977, 984, Mar. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: High tibial osteotomy (HTO) reduces the load distribution of the medial compartment by modifying leg alignment. Knee adduction moment (KAM), a surrogate measure of dynamic loading in the knee joint, decreases after HTO. However, leg alignment does not fully account for KAM. PURPOSE: To assess the association between the pelvis-knee-ankle angle (PKA), a novel radiographic parameter reflecting leg alignment and pelvic width, and KAM and patient-reported outcomes after HTO. STUDY DESIGN: Cross sectional study; Level of evidence, 3. METHODS: PKA is the angle between the line from the midpoint of the anterior superior iliac spine to the center of the knee joint and the mechanical axis of the tibia. In this study, 54 patients with medial compartment knee osteoarthritis and varus alignment who underwent 3-dimensional gait analysis preoperatively and 2 years after medial open-wedge HTO were evaluated. The primary outcomes were hip-knee-ankle angle (HKA), PKA, KAM peaks, and Knee Society Score (KSS). Single and multivariate regression analysis including PKA and KAM peaks as well as other demographic and radiologic factors was performed. RESULTS: HKA was weakly correlated with the first peak KAM (r = -0.33; P < .01) and second peak KAM (r = -0.27; P = .01) before HTO, but not significantly correlated after HTO. PKA was moderately correlated with the first peak KAM (r = 0.45; P < .01) and second peak KAM (r = 0.45; P < .01) before HTO and with the first peak KAM (r = 0.51; P < .01) and second peak KAM (r = 0.56; P < .01) after HTO. Multivariate linear regression revealed that postoperative PKA was still associated with the KAM peaks after HTO. Only postoperative PKA was correlated with the KSS satisfaction subscale (r = -0.30; P = .03). CONCLUSION: Although HKA was not correlated with KAM peaks after HTO, PKA was significantly correlated with KAM peaks in patients with varus knee osteoarthritis after HTO.

Three-stage total knee arthroplasty combined with deformity correction and leg lengthening using Taylor spatial frames and conversion to internal fixation for severe intra- and extra-articular deformities and hypoplasia in a patient with hemophilic knee arthropathy: A case report.
Akira Fukushima, Koji Iwasaki, Ryousuke Hishimura, Shinji Matsubara, Zenta Joutoku, Masatake Matsuoka, Tomoyuki Endo, Tomohiro Onodera, Eiji Kondo, Norimasa Iwasaki
The Knee, 40, 90, 96, Jan. 2023, [International Magazine]
English, BACKGROUND: Hemophilic arthropathy is a cause of severe knee deformity, because chronic synovitis due to repeated hemarthrosis affects the area of the epiphyseal plates in juvenile cases. Total knee arthroplasty (TKA) is the standard treatment for end-stage knee arthropathy. However, it is difficult to perform one-stage TKA in patients with severe intra- and extra-articular deformities. CASE PRESENTATION: We reported a case of hemophilic arthropathy in a 55-year-old male with leg length discrepancy of 4 cm, limited range of knee motion (-40° extension and 85° flexion), intra-articular deformity (medial proximal tibial angle: 69°; mechanical lateral distal femoral angle: 79°), extra-articular deformity at the distal femoral metaphyseal (30° valgus and 45° flexion deformity), and varus malalignment (% mechanical axis: 33%). We planned a three-stage TKA. Firstly, we performed gradual correction and lengthening of the distal femur using Taylor spatial flame. Six months after surgery, we performed conversion surgery from external fixation to internal fixation. Finally, we performed TKA with rotating hinged type implant. Two years after surgery, physical examination showed a normal gait, leg length discrepancy of 2 cm (the right leg was shorter), improvement in the range of knee motion (0° extension and 100° flexion). CONCLUSION: To the best of our knowledge, this presents the first combination of three-stage TKA with correction of femoral deformity and leg lengthening using a Taylor spatial frame and conversion to internal fixation in a patient with hemophilic knee arthropathy and severe intra- and extra-articular deformities.

Comparison of clinical features between patients with bone and soft tissue fibrosarcomas.
Masatake Matsuoka, Tomohiro Onodera, Isao Yokota, Koji Iwasaki, Ryosuke Hishimura, Yuki Suzuki, Eiji Kondo, Norimasa Iwasaki
Journal of surgical oncology, 126, 7, 1299, 1305, Dec. 2022, [International Magazine]
English, Scientific journal, BACKGROUND AND OBJECTIVES: Fibrosarcomas predominantly arise in soft tissues, but can also develop in bone. Because of their rarity, whether bone development has an impact on clinical features has not been addressed. METHODS: We included fibrosarcoma patients diagnosed between 1983 and 2016 in the Surveillance, Epidemiology, and End Results database. Differences in clinical features between fibrosarcoma of bone (FS-B) and fibrosarcoma of soft tissue (FS-ST) were investigated. RESULTS: After excluding patients without information regarding cause of death, site of origin, distant tumor or survival, 1443 patients were included. Of those, 98 patients had FS-B. Patients with FS-B were younger, more frequently male, with fibrosarcomas that more often developed in an extremity and were histologically high-grade. In contrast, no difference in potential to metastasize was observed. Survival was almost equal between FS-B and FS-ST (FS-B/FS-ST: cancer-specific survival, hazard ratio [HR]: 1.2, 95% confidence interval [CI]: 0.8-1.7; overall survival, HR: 1.3, 95% CI: 0.9-1.7). CONCLUSIONS: Our results clearly indicated that patient backgrounds differed, such as younger age and greater tendencies to affect males, develop in an extremity and show high-grade tumor in patients with FS-B. In contrast, no differences were observed in distant metastatic potential or survival.

Establishment of the removal method of undifferentiated induced pluripotent stem cells coexisting with chondrocytes using R-17F antibody.
Takuji Miyazaki, Hisatoshi Hanamatsu, Tomohiro Onodera, Jun-Ichi Furukawa, Liang Xu, Kentaro Homan, Rikiya Baba, Toshisuke Kawasaki, Norimasa Iwasaki
Regenerative medicine, 17, 11, 793, 803, Nov. 2022, [International Magazine]
English, Scientific journal, Aim: Tumorigenicity of residual undifferentiated induced pluripotent stem cells (iPSCs) is a major concern. The purpose of this study was to investigate the optimal conditions for removal of iPSCs using R-17F antibody, which recognizes specific glycosphingolipids glycans on undifferentiated iPSCs and exhibits selective cytotoxicity to iPSCs. Materials & methods: After adding of R-17F and secondary antibody to co-cultured iPSCs and chondrocytes, residual iPSCs were quantitatively evaluated by iPS specific glycome analysis. Results: Undifferentiated iPSCs were sufficiently removed using R-17F in combination with an equal amount of a secondary antibody. Furthermore, teratomas were not observed upon transplantation of co-cultured cells pretreated under the same conditions into testes of immunodeficient mice. Conclusion: This removal method incorporating R-17F may be useful for regenerative medicine using iPSCs.

Occurrence Rate of Cyclops Lesion After Anatomic Double-Bundle ACL Reconstruction: Comparison Between Remnant Tissue Preservation and Resection Methods.
Ryosuke Hishimura, Eiji Kondo, Yuki Suzuki, Masatake Matsuoka, Koji Iwasaki, Tomohiro Onodera, Daisuke Momma, Tomonori Yagi, Kazunori Yasuda, Norimasa Iwasaki
Orthopaedic journal of sports medicine, 10, 10, 23259671221130688, 23259671221130688, Oct. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: The occurrence rate of cyclops lesion after anatomic double-bundle anterior cruciate ligament (ACL) reconstruction with remnant tissue preservation remains unclear. HYPOTHESIS: The study hypotheses were as follows: (1) the occurrence rate of cyclops lesion will be comparable between the remnant-preserving and remnant-resecting ACL reconstruction methods, and (2) there will be no significant differences in clinical outcomes between the remnant-preserving and remnant-resecting procedures. METHODS: This retrospective comparative study involved 177 patients who underwent unilateral anatomic double-bundle ACL reconstruction using hamstring tendon autografts from 2014 to 2018 at our hospital. According to the Crain classification of ACL remnant tissue, 98 patients with remnant types I, II, or III underwent the remnant-preserving procedure (group A), and the remaining 79 patients with remnant type IV underwent the remnant-resecting procedure (group B). All patients underwent second-look arthroscopy. Patients were evaluated according to arthroscopic and clinical results at postoperative 15.2 ± 8.4 months (mean ± SD). Statistical comparisons between groups were made using the paired Student t test, chi-square test, and Fisher exact test. STUDY DESIGN: Cohort study; Level of evidence, 3. RESULTS: At second-look arthroscopy, the incidence of cyclops lesions was significantly higher in group B than in group A (29.1% vs 13.3%; P = .0139). Cyclops lesions were divided into 4 locations: femoral side (type 1), midsubstance (type 2), tibial side (type 3), and anterior (type 4) of the ACL graft. The ratio of the tibial-side cyclops lesion (type 3) was significantly higher in group B than in group A (P = .0354). There were no significant differences in the clinical evaluation scores between the procedures. Side-to-side anterior laxity was significantly less in group A than in group B (0.7 vs 1.6 mm; P = .0035). Concerning postoperative laceration and synovium coverage of the grafts, group A was significantly better than group B (P < .0001). CONCLUSION: In this cohort of patients undergoing double-bundle ACL reconstruction, resection of the ACL remnant was associated with a significantly higher rate of cyclops lesion formation when compared with preservation of the remnant.

変形性膝関節症における歩行中の関節面傾斜の変化 ウェアラブルセンサーによる歩行解析
岩崎 浩司, 佐橋 健人, 安倍 雄一郎, 千葉 健, 小野寺 智洋, 近藤 英司, 遠山 晴一
日本整形外科学会雑誌, 96, 8, S1788, S1788, (公社)日本整形外科学会, Sep. 2022
Japanese

軟骨細胞パイロトーシス制御による軟骨変性抑制効果
江畑 拓, 照川 アラー, 横田 隼一, 照川 ヘンド, 松前 元, 清水 智弘, 高橋 大介, 小野寺 智洋, 角家 健, 岩崎 倫政
日本整形外科学会雑誌, 96, 8, S1580, S1580, (公社)日本整形外科学会, Sep. 2022
Japanese

In Reply to the Letter to the Editor Regarding "Does Primary Tumor Resection in Patients with Metastatic Primary Mobile Vertebral Column Sarcoma Improve the Survivals?".
Masatake Matsuoka, Tomohiro Onodera, Isao Yokota, Norimasa Iwasaki
World neurosurgery, 165, 210, 210, Sep. 2022, [International Magazine]
English

変形性膝関節症における歩行中の関節面傾斜の変化 ウェアラブルセンサーによる歩行解析
岩崎 浩司, 佐橋 健人, 安倍 雄一郎, 千葉 健, 小野寺 智洋, 近藤 英司, 遠山 晴一
日本整形外科学会雑誌, 96, 8, S1788, S1788, (公社)日本整形外科学会, Sep. 2022
Japanese

Liver metastasis in soft tissue sarcoma at initial presentation.
Yuta Kawae, Masatake Matsuoka, Tomohiro Onodera, Isao Yokota, Koji Iwasaki, Ryosuke Hishimura, Yuki Suzuki, Eiji Kondo, Norimasa Iwasaki
Journal of surgical oncology, 126, 6, 1074, 1079, 06 Jul. 2022, [International Magazine]
English, Scientific journal, BACKGROUND AND OBJECTIVES: Noncontrast computed tomography of the chest is the standard imaging modality for cancer staging in patients with soft tissue sarcoma (STS), but appropriate candidates for liver screening have not been clarified. METHODS: We reviewed all patients with STS diagnosed between 2010 and 2018 in the Surveillance, Epidemiology, and End Results database. Incidence of liver metastasis at initial presentation and high incidence of liver metastasis by histological subtype were investigated. In addition, risk factors for liver metastasis were investigated by multiple logistic regression analysis. RESULTS: After excluding patients without information about liver metastasis, cause of death or primary liver tumor, 47 260 patients were included in this study. Of those, 1471 patients (3.2%) showed liver metastasis at initial presentation. The histological subtype showing the highest incidence of liver metastasis was desmoplastic small round cell tumor (30.3%), followed by malignant hemangioendothelioma (11.5%) and angiomyoliposarcoma (10.5%). Deep-rooted tumor, location in the body wall, retroperitoneum, or thorax/peritoneum, high histological grade, and higher T stage were associated with higher incidences of liver metastasis at initial presentation. CONCLUSION: Risk factors for liver metastasis were deep location, trunk development, larger tumor size, high histological grade, and specific histological subtypes.

Effect of the Inverted V-Shaped Osteotomy on Patellofemoral Joint and Tibial Morphometry as Compared With the Medial Opening Wedge High Tibial Osteotomy.
Eiji Kondo, Koji Yabuuchi, Zenta Joutoku, Shinji Matsubara, Koji Iwasaki, Masatake Matsuoka, Tomohiro Onodera, Daisuke Momma, Masayuki Inoue, Tomonori Yagi, Norimasa Iwasaki, Kazunori Yasuda
The American journal of sports medicine, 50, 9, 2439, 2452, Jul. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: Recent studies have reported that medial opening wedge (OW) high tibial osteotomy (HTO) induces patella baja, resulting in degenerative changes in the patellofemoral joint. We have developed an inverted V-shaped (iV) HTO, which is classified as a neutral wedge osteotomy. HYPOTHESES: The study hypotheses were as follows: (1) patellar height, posterior tibial slope, and tibial length will not change between pre- and postoperative evaluations after iV-HTO; (2) the lateral shift ratio of the patella and the distance between the tibial tubercle and the trochlear groove may be significantly decreased after iV-HTO. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: A total of 191 patients (220 knees) who underwent HTO for medial osteoarthritis were enrolled retrospectively in this study: 107 knees underwent OW-HTO and 113 knees underwent iV-HTO. Clinical and radiological evaluations were performed before and at least 3 years after surgery. RESULTS: Postoperatively, the mean Caton-Deschamps ratio was significantly decreased (P < .0001) from 0.95 to 0.79 in the OW group, while there were no significant changes in the iV group. The mean posterior tibial slope was significantly increased (P < .0001) from 8.5° to 10.5° in the OW group, while there were no significant differences in the iV group. Although the entire leg length was significantly increased (P < .0003) in both groups after HTO, there were no significant differences in tibial length between the pre- and postoperative periods in the iV group. Regarding the congruity of the patellofemoral joint, the mean lateral shift ratio did not significantly change in the OW group, whereas it was significantly decreased (P = .0012) from 11.5% to 8.8% in the iV group. The mean tibial tubercle-trochlear groove distance was significantly decreased (P < .0001) from 12.8 to 9.7 mm in the iV group, while it was significantly increased in the OW group (P < .0001). Concerning the clinical outcome, the Japanese Orthopaedic Association (JOA) and Lysholm knee scores at final follow-up (OW vs iV: JOA, 91.2 vs 90.1; Lysholm, 92.5 vs 89.0) were significantly increased (P < .0001) as compared with the preoperative values (OW vs iV: JOA, 68.3 vs 66.8; Lysholm, 67.9 vs 61.0). CONCLUSION: Patellar height, posterior tibial slope, and tibial length did not change after the iV-HTO, while they were significantly changed after the OW-HTO. Although the preoperative degrees of varus knee and patellofemoral osteoarthritis were more severe in the iV group than the OW group, the iV-HTO led to altered patellofemoral joint congruity.

Does Primary Tumor Resection in Patients with Metastatic Primary Mobile Vertebral Column Sarcoma Improve Survival?
Masatake Matsuoka, Tomohiro Onodera, Isao Yokota, Koji Iwasaki, Ryosuke Hishimura, Yuki Suzuki, Akira Iwata, Eiji Kondo, Norimasa Iwasaki
World neurosurgery, 163, e647-e654, 18 Apr. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: Primary mobile vertebral column sarcoma is an exceedingly rare malignancy. Although primary tumor resection has been reported to prolong survival in patients with metastatic bone sarcoma, whether primary tumor resection in patients with advanced primary mobile vertebral column sarcoma is associated with survival remains unclear owing to the rarity of this pathological entity. METHODS: Using the Surveillance, Epidemiology, and End Results database, 182 patients with metastatic primary mobile vertebral column sarcoma were identified between 1983 and 2015. Of the 182 patients enrolled, 101 patients (55%) underwent primary tumor resection (Surgery group) and 81 patients (45%) did not undergo resection (No Surgery group). To account for imbalances in the basic characteristics of patients between groups, propensity score matching was performed. Survival analysis was performed by weighted Cox proportional hazards modeling to calculate hazard ratios. RESULTS: After adjusting for patient background characteristics, 138 patients were included for the analysis (Surgery group: 69 patients; No Surgery group: 69 patients). The Surgery group did not show improved cancer-specific survival (hazard ratio = 0.73, 95% CI 0.49-1.10). Similarly, the Surgery group did not show improved overall survival compared with the No Surgery group (hazard ratio = 0.80, 95% CI 0.55-1.16). CONCLUSIONS: To our knowledge, this is the first study to indicate that surgical resection for advanced primary mobile vertebral column sarcoma does not have a positive impact on survival.

Intra-articular osteoid osteoma at the elbow mimicking arthritis: a case report
Ryuichi Fukuda, Masatake Matsuoka, Daisuke Kawamura, Takeshi Endo, Hiromi Kanno-Okada, Atsushi Urita, Yuichiro Matsui, Tomohiro Onodera, Norimasa Iwasaki
Annals of Joint, 7, 20, 20, AME Publishing Company, Apr. 2022
Scientific journal

Optical coherence tomography evaluation of the spatiotemporal effects of 3D bone marrow stromal cell culture using a bioreactor.
Jun Yamaguchi, Tomohiro Onodera, Kentaro Homan, Xu Liang, Masatake Matsuoka, Takuji Miyazaki, Hosokawa Yoshiaki, Mitsuru Saito, Norimasa Iwasaki
Journal of biomedical materials research. Part B, Applied biomaterials, 110, 8, 1853, 1861, 09 Mar. 2022, [International Magazine]
English, Scientific journal, Performing cell culture in a three-dimensional (3D) environment has various advantages. In cartilage tissue engineering, 3D in vitro cultures utilizing biomaterials and bioreactors can mimic the biological environment. However, the biggest drawback of these 3D culture systems is a limited ability to evaluate 3D cell distribution. Optical coherence tomography (OCT) has recently been used to evaluate 3D cellular morphology and structure in a timely manner. Here, we showed that OCT could be used to visually assess the distribution and the morphology of bone marrow stromal cells under chondrogenic 3D cultivation using alginate gels and rotary culture. In particular, OCT was able to visualize living cells embedded in alginate gels in a non-destructive and 3D manner, as well as quantitatively evaluate cell distribution and spheroid volume. We also found that cells were centralized in rotary culture but peripherally distributed in static culture, while rotary culture enhanced the hypertrophy of marrow stromal cells (MSCs) embedded in alginate gels. Together, our findings demonstrate that OCT can be used to evaluate the spatiotemporal effects of 3D cultivation using alginate gels and rotary culture. Therefore, this method may allow the observation of pre-cultured tissue over time and the optimization of culture conditions for regenerative tissue engineering.

関節リウマチ患者の下肢手術数の傾向と併存症発生に関する調査
糸賀 稜, 清水 智弘, 高橋 大介, 小野寺 智洋, 岩崎 倫政
日本整形外科学会雑誌, 96, 2, S334, S334, (公社)日本整形外科学会, Mar. 2022
Japanese

関節リウマチ患者の下肢手術数の傾向と併存症に関する調査　　　　　　　　　　　　　　　
糸賀 稜, 清水 智弘, 小野寺 智洋, 岩崎 倫政
日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 623, 623, (一社)日本リウマチ学会, Mar. 2022
Japanese

Double-bundle anterior cruciate ligament reconstruction using autologous hamstring tendon hybrid grafts in a patient with hypermobile Ehlers-Danlos Syndrome: A case report.
Ryosuke Hishimura, Eiji Kondo, Masatake Matsuoka, Koji Iwasaki, Yasuyuki Kawaguchi, Yuki Suzuki, Tomohiro Onodera, Daisuke Momma, Norimasa Iwasaki
The Knee, 35, 81, 86, Mar. 2022, [International Magazine]
English, BACKGROUND: Ehlers-Danlos syndrome (EDS) is a connective tissue disorder characterized by skin hyperextensibility, joint hypermobility, and tissue friability. Hypermobile type Ehlers-Danlos syndrome (hEDS) is considered one of the EDS subtypes characterized by generalized joint hypermobility. Although there have been a few case reports which described surgical considerations for anterior cruciate ligament (ACL) reconstructions in patients with other types of EDS, no reports have described those in patients with hEDS. CASE PRESENTATION: We report a case of ACL injury in an 18-year-old male patient with hEDS. The patient was successfully treated with an anatomic double-bundle ACL reconstruction using autologous hamstring tendon hybrid grafts which consist of hamstring tendons connected in a series with commercially available polyester tape. The autogenous tendon portion of the anteromedial and posterolateral bundles were composed of 4 and 2 strands of hamstring tendons, respectively. After 2 weeks of knee joint immobilization, continuous passive motion exercise of the knee joint and partial weight-bearing was allowed. A hinged knee brace was used for a period of 5 months postoperatively. Second-look arthroscopy at 30 months showed that the ACL graft had no laceration and an excellent coverage of the synovium. At 36 months after surgery, the side-to-side differences in the anterior laxity was remarkably improved. The operated knee showed negative Lachman test and had a full range of motion. CONCLUSIONS: To the best of our knowledge, this represents the first report of anatomic double-bundle ACL reconstruction in patients with hEDS and demonstrates excellent clinical and functional outcomes.

変形性膝関節症患者における膝および体幹の加速度と膝関節伸展筋力との関係 ウェアラブルセンサーを用いて
佐橋 健人, 岩崎 浩司, 千葉 健, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 遠山 晴一
日本整形外科学会雑誌, 96, 2, S75, S75, (公社)日本整形外科学会, Mar. 2022
Japanese

関節リウマチ患者の下肢手術数の傾向と併存症に関する調査　　　　　　　　　　　　　　　
糸賀 稜, 清水 智弘, 小野寺 智洋, 岩崎 倫政
日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 623, 623, (一社)日本リウマチ学会, Mar. 2022
Japanese

手指原発の悪性骨腫瘍における特徴 米国SEERデータベースを用いた研究
池 翔太, 松岡 正剛, 小野寺 智洋, 横田 勲, 岩崎 浩司, 菱村 亮介, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 96, 3, S609, S609, (公社)日本整形外科学会, Mar. 2022
Japanese

四肢原発軟部肉腫症例における患肢温存術と切断術の比較 米国SEERデータベースを用いた研究
松岡 正剛, 小野寺 智洋, 横田 勲, 岩崎 浩司, 菱村 亮介, 鈴木 裕貴, 岩田 玲, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 96, 3, S1156, S1156, (公社)日本整形外科学会, Mar. 2022
Japanese

初診時遠隔転移を有する椎体発生悪性骨腫瘍において原発巣切除は生存を改善するか 米国SEERデータベースを用いた研究
松岡 正剛, 小野寺 智洋, 横田 勲, 岩崎 浩司, 菱村 亮介, 鈴木 裕貴, 岩田 玲, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 96, 3, S1157, S1157, (公社)日本整形外科学会, Mar. 2022
Japanese

関節リウマチ患者の下肢手術数の傾向と併存症発生に関する調査
糸賀 稜, 清水 智弘, 高橋 大介, 小野寺 智洋, 岩崎 倫政
日本整形外科学会雑誌, 96, 2, S334, S334, (公社)日本整形外科学会, Mar. 2022
Japanese

Primary Malignant Osseous Neoplasms in the Hand.
Shota Ike, Masatake Matsuoka, Tomohiro Onodera, Isao Yokota, Koji Iwasaki, Ryosuke Hishimura, Yuki Suzuki, Eiji Kondo, Norimasa Iwasaki
Anticancer research, 42, 3, 1635, 1640, Mar. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: Primary malignant osseous neoplasms of the hand are rare malignancies. Comprehensive demographic and survival data regarding primary malignant osseous neoplasms of the hand are lacking in the literature. PATIENTS AND METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified all patients with primary malignant osseous neoplasms of the hand diagnosed between 1983 and 2015. Demographic data were searched for primary osseous neoplasms in the hand and higher incidence of histological subtype. RESULTS: A total of 197 patients were analyzed: 103 patients were diagnosed with histologically low-grade tumor, and 31 were diagnosed with high-grade tumor. Five-year cancer-specific and overall survival rates for the entire cohort were 91.4% and 81.9%, respectively. Histological high tumor grade and regional stage from SEER historic stage data were associated with unfavorable cancer-specific survival. CONCLUSION: Special caution is required if patients have histologically high-grade tumor or tumor extending beyond the periosteum into surrounding joints, as these features worsen cancer-specific mortality.

The effect of local injection of tranexamic acid into peri-articular tissue versus drain clamping in total knee arthroplasty: a randomized controlled trial.
Ryosuke Hishimura, Tomohiro Onodera, Yasumitsu Ohkoshi, Kazufumi Okada, Masatake Matsuoka, Shinji Matsubara, Koji Iwasaki, Eiji Kondo, Norimasa Iwasaki
BMC musculoskeletal disorders, 23, 1, 111, 111, 02 Feb. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: Tranexamic acid (TXA) is used as a synthetic anti-fibrinolytic agent for total knee arthroplasty (TKA) to reduce postoperative bleeding. Though the effects on bleeding reduction of several methods of administering TXA have been demonstrated, the optimal method remains controversial. Recently, the hemostatic effect of periarticular local injection of TXA during TKA was reported. Although this method can be expected to suppress postoperative bleeding without placing a drain, its hemostatic effect has not yet been assessed in comparison with local injection and other methods of administering TXA. The aim of this randomized, prospective study was to assess the efficacy of local injection of TXA during TKA. METHODS: To confirm the effect of the local injection of TXA, drain clamping was set as the control. The subjects included a prospective series of 109 patients randomly divided into 2 groups: the local injection (group L) and the drain clamping (group D). The main outcome measure was postoperative bleeding. Secondary outcomes included pain, physical measurements, and laboratory findings. RESULTS: The calculated total blood loss (CTBL) in groups L and D was nearly equal and did not show the non-inferiority of group L to group D (883 ± 248 vs. 841 ± 257 ml, P = .564). Drained blood loss was significantly higher in group L than in group D (395 ± 130 vs 276 ± 78.8 ml, P < .0001). There was no significant difference in hidden blood loss between the groups (488 ± 269 vs 565 ± 261 ml, P = .131). The other laboratory findings and physical measurements were identical between the groups. CONCLUSIONS: Although CTBL in group L did not show non-inferiority to group D, the local injection of TXA was considered to be superior for suppressing bleeding considering the risk of the adverse effects of using a drain. TRIAL REGISTRATION: This was a randomized, prospective study registered with UMIN Clinical Trials Registry (Registration number: UMIN000036146, date of disclosure: 10/3/2019).

変形性関節症の病態におけるマクロファージの役割　　　　　　　　　　　　　　　
小野寺 智洋, 江畑 拓, 濱崎 雅成, 照川 アラー, 岩崎 倫政
リウマチ科, 67, 2, 216, 220, (有)科学評論社, Feb. 2022
Japanese

Discrepancy in the Distribution Patterns of Subchondral Bone Density Across the Ankle Joint After Medial Opening-Wedge and Lateral Closing-Wedge High Tibial Osteotomy.
Shinji Matsubara, Tomohiro Onodera, Koji Iwasaki, Ryosuke Hishimura, Masatake Matsuoka, Eiji Kondo, Norimasa Iwasaki
The American journal of sports medicine, 50, 2, 478, 485, Feb. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: High tibial osteotomy (HTO) changes the alignment and dynamics of the ankle joint; however, differences in the stress distribution of the ankle joint after opening-wedge HTO (OWHTO) and closing-wedge HTO (CWHTO) are not understood. It is believed that subchondral bone density of the articular surface reflects the pattern of cumulative stress distribution across the joint surface. PURPOSE: To clarify the effects of OWHTO and CWHTO on the distribution patterns of subchondral bone density across the ankle joint using computed tomography (CT)-osteoabsorptiometry. STUDY DESIGN: Cohort study; Level of evidence, 4. METHODS: Radiographic and CT data of 18 cases who underwent OWHTO (OW group), 12 cases who underwent CWHTO (CW group), and 11 cases with unilateral anterior cruciate ligament injury serving as controls were retrospectively reviewed. The subchondral bone density of the distal tibia was assessed in the 3 groups using CT-osteoabsorptiometry. The distal tibial surface of the ankle joint was divided into 4 parts in the coronal direction, and the percentage of the high-density area (%HDA) to each subregion was compared before and after HTO. RESULTS: Preoperatively, comparing %HDA among the 3 groups, there were no significant differences in any regions. In the OW group, postoperative %HDA in the most medial region was significantly increased compared with preoperative %HDA (49.3% to 53.0%; P = .011), and postoperative %HDA in the most lateral region was significantly decreased (21.4% to 17.2%; P = .003). On the other hand, in the CW group, postoperative %HDA in the most medial region was significantly decreased (55.7% to 35.7%; P = .001), and %HDA in the second lateral region was significantly increased (23.6% to 29.2%; P = .002). CONCLUSION: The ankle distribution pattern of subchondral bone density shifted significantly medially after OWHTO without fibular osteotomy, whereas the distribution pattern shifted laterally after CWHTO with fibular osteotomy. When the OWHTO is performed for patients with medial ankle osteoarthritis, surgeons should pay attention to potential postoperative progression of ankle osteoarthritis due to medial shift of the stress distribution in the ankle joint.

Establishment of a New Qualitative Evaluation Method for Articular Cartilage by Dynamic T2w MRI Using a Novel Contrast Medium as a Water Tracer.
Yoshiaki Hosokawa, Tomohiro Onodera, Kentaro Homan, Jun Yamaguchi, Kohsuke Kudo, Hiroyuki Kameda, Hiroyuki Sugimori, Norimasa Iwasaki
Cartilage, 13, 3, 19476035221111503, 19476035221111503, Jul. 2022, [International Magazine]
English, Scientific journal

Surgical resection of primary tumor in the extremities improves survival for metastatic soft-tissue sarcoma patients: a population-based study of the SEER database.
M Matsuoka, T Onodera, I Yokota, K Iwasaki, S Matsubara, R Hishimura, E Kondo, N Iwasaki
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 23, 12, 2474, 2481, Dec. 2021, [International Magazine]
English, Scientific journal, PURPOSE: The objectives of this study were to clarify whether resection of primary tumor in the extremities for patients with metastatic soft-tissue sarcoma (STS) improves survival, and to clarify patient groups for whom primary tumor resection should be considered. METHODS/PATIENTS: Using the surveillance, epidemiology, and end results database, we identified 1453 patients with metastatic STS of the extremities at initial presentation between 1983 and 2016. Of these 1453 patients, 898 patients underwent primary tumor resection (Surgery group), and 555 patients did not (No-surgery group). RESULTS: After adjusting for patient background by propensity score matching, a total of 804 patients were included for analysis. Patients in the Surgery group showed improved survival (cancer-specific survival (CSS) hazard ratio (HR) = 0.59, 95% confidence interval (CI) 0.50-0.71 overall survival rate (OS) HR = 0.60, 95% CI 0.51-0.70). In subclass analysis, patients with high-grade STS, undifferentiated pleomorphic sarcoma, leiomyosarcoma, or synovial sarcoma showed improved survival in the Surgery group (high grade-CSS HR = 0.57, 95% CI 0.45-0.72, OS HR = 0.58, 95% CI 0.48-0.71; undifferentiated pleomorphic sarcoma-CSS HR = 0.60, 95% CI 0.42-0.84, OS HR = 0.61, 95% CI 0.46-0.82; leiomyosarcoma-CSS HR = 0.50, 95% CI 0.33-0.75, OS HR = 0.50, 95% CI 0.35-0.72; synovial sarcoma-CSS HR = 0.46, 95% CI 0.31-0.68, OS HR = 0.43, 95% CI 0.30-0.62). CONCLUSIONS: Our results indicated that primary tumor resection in metastatic STS exerts positive impacts on survival. Further clinical research is needed to confirm these results.

Quantification of Cartilage Surface Degeneration by Curvature Analysis Using 3D Scanning in a Rabbit Model.
Dawei Liang, Tomohiro Onodera, Masanari Hamasaki, Ryosuke Hishimura, Kentaro Homan, Liang Xu, Yuan Tian, Satoshi Kanai, Norimasa Iwasaki
Cartilage, 13, 2_suppl, 1734S-1741S, Dec. 2021, [International Magazine]
English, Scientific journal, OBJECTIVE: Accurate analysis to quantify cartilage morphology is critical for evaluating degenerative conditions in osteoarthritis (OA). Three-dimensional (3D) optical scanning provides 3D data for the entire cartilage surface; however, there is no consensus on how to quantify it. Our purpose was to validate a 3D method for evaluating spatiotemporal alterations in degenerative cartilages in a rabbit OA model by analyzing their curvatures at various stages of progression. DESIGN: Twelve rabbits underwent anterior cruciate ligament transection (ACLT) unilaterally and were divided into 4 groups: 4 weeks control, 4 weeks OA, 8 weeks control, and 8 weeks OA. 3D scanning, India ink staining, and histological assessments were performed in all groups. In 3D curvature visualization, the surfaces of the condyles were divided into 8 areas. The standard deviations (SD) of mean curvatures from all vertices of condylar surfaces and subareas were calculated. RESULTS: Regarding the site of OA change, curvature analysis was consistent with India ink scoring. The SD of mean curvature correlated strongly with the India ink Osteoarthritis Research Society International (OARSI) score. In curvature histograms, the curvature distribution in OA was more scattered than in control. Of the 8 areas, significant OA progression in the posterolateral part of the lateral condyle (L-PL) was observed at 4 weeks. The histology result was consistent with the 3D evaluation in terms of representative section. CONCLUSIONS: This study demonstrated that 3D scanning with curvature analysis can quantify the severity of cartilage degeneration objectively. Furthermore, the L-PL was found to be the initial area where OA degeneration occurred in the rabbit ACLT model.

No patella resurfacing total knee arthroplasty leads to reduction in the thickness of patellar cartilage to less than half within 5 years: a quantitative longitudinal evaluation using MRI.
Dai Sato, Masayuki Inoue, Takuro Sasaki, Jun Uchida, Tomohiro Onodera, Eiji Kondo, Norimasa Iwasaki
Journal of experimental orthopaedics, 8, 1, 107, 107, 24 Nov. 2021, [International Magazine]
English, Scientific journal, PURPOSE: Patellar resurfacing in total knee arthroplasty (TKA) remains controversial as recent meta-analyses have not shown its clear superiority; however, most authors recommend it because it is associated with less frequent anterior knee pain and need for reoperation. We aimed to clarify the changes in patellar cartilage thickness in no patellar resurfacing TKA using a ceramic femoral component on magnetic resonance imaging (MRI). METHODS: Between 2009 and 2014, 40 consecutive patients (59 knees) were included in this study. All patients underwent TKA using zirconia ceramic femoral implants without patellar resurfacing. Indications for no patellar resurfacing TKA were absence of anterior knee pain, patellar compression pain, and osteoarthritic changes in the patellofemoral joint on plain radiography. The mean postoperative follow-up duration was 81.5 months (range, 25-131 months). Clinical and radiological evaluations were performed preoperatively and 5 years after TKA. Patellar cartilage thickness was evaluated preoperatively and every year for 5 years after TKA using MRI T2-weighted imaging. The patellar cartilage was divided into three regions of interest: medial, central, and lateral. To standardise the variation in patellar thickness among patients, the percent cartilage thickness was calculated. RESULTS: The implant's position was appropriate in all cases. Compared to preoperative scores, 5 years postoperatively, the Japanese Orthopedic Association score and Oxford knee score significantly improved from 52.1 to 84.7; mean tilting angle and congruence angle did not change significantly; mean lateral shift ratio significantly increased from 7.1% to 14.6%; cartilage thickness significantly decreased (P < 0.05); and the percentage cartilage thickness of the central, medial, and lateral cartilage zones gradually thinned to less than half. Four patients underwent conversion to patellar resurfacing due to anterior knee pain, without loosening the femoral and tibial implants. CONCLUSION: The patellar cartilage thickness decreased to less than half its preoperative level within 5 years after no patellar resurfacing TKA; this would led to clinical problems and conversion to patellar resurfacing. LEVEL OF EVIDENCE: Level III.

関節リウマチ患者の2010年以降の下肢手術数の動向と併存症発生に関する調査
糸賀 稜, 清水 智弘, 高橋 大介, 小野寺 智洋, 岩崎 倫政
日本関節病学会誌, 40, 3, 285, 285, (一社)日本関節病学会, Nov. 2021
Japanese

Brain Metastasis in Soft Tissue Sarcoma at Initial Presentation.
Ryo Itoga, Masatake Matsuoka, Tomohiro Onodera, Isao Yokota, Koji Iwasaki, Shinji Matsubara, Ryosuke Hishimura, Yuki Suzuki, Akira Iwata, Eiji Kondo, Norimasa Iwasaki
Anticancer research, 41, 11, 5611, 5616, Nov. 2021, [International Magazine]
English, Scientific journal, BACKGROUND/AIM: Brain metastasis is a rare condition among patients with soft tissue sarcoma (STS), and its precise incidence remains unclear. The aim of this study was to investigate which patients should be screened for brain metastasis. PATIENTS AND METHODS: We identified all patients with STS diagnosed between 2010 and 2015 in the SEER database. Incidence of brain metastasis at initial presentation and higher incidence of brain metastasis by histological subtype were investigated. In addition, risk factors for brain metastasis were examined. RESULTS: A total of 26,676 patients were included for analysis, of whom 162 patients (0.6%) had brain metastasis. Alveolar soft part sarcoma (6.3%), malignant hemangioendothelioma (3.1%) and malignant schwannoma (2.6%) showed higher incidence of brain metastasis. Deep-rooted tumor, trunk tumor, and histological high-grade tumor tended to show higher incidence of brain metastasis. CONCLUSION: Risk factors for brain metastasis were deep location, trunk development and histologically high-grade tumor, or specific histological subtypes.

Stress on the posteromedial region of the proximal tibia increased over time after anterior cruciate ligament injury.
Soya Miura, Koji Iwasaki, Eiji Kondo, Kaori Endo, Shinji Matsubara, Masatake Matsuoka, Tomohiro Onodera, Norimasa Iwasaki
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 30, 5, 1744, 1751, 10 Sep. 2021, [International Magazine]
English, Scientific journal, PURPOSE: Anterior cruciate ligament (ACL) injury induces anterior and rotatory instability of the knee. However, the effect of this instability on the stress distribution in the knee joint in living participants is not clear. The aim of this study was to compare the distribution pattern of subchondral bone density across the proximal tibia in the knees with and without ACL injury, and to investigate the correlation between the distribution patterns of the subchondral bone density and the duration of ACL-deficiency. METHODS: Radiographic and computed tomography (CT) data pertaining to 20 patients with unilateral ACL injury without combined injury (ACL-deficient group) and 19 nontraumatic subjects (control group) were collected retrospectively. Subchondral bone density of the proximal tibia was assessed using CT-osteoabsorptiometry. Both the medial and lateral compartments of the proximal tibia were divided into three subregions of equal width in the sagittal direction. The percentage of high subchondral bone density areas (HDA%) in each subregion was quantitatively analyzed. RESULTS: HDA% of the posteromedial region was significantly higher in the ACL-deficient group (mean: 21.6%) than in the control group (14.7%) (p = 0.002). In contrast, HDA% of the anteromedial region was significantly lower in the ACL-deficient group (9.4%) than in the control group (15.3%) (p = 0.048). The logarithm of the time elapsed from ACL injury to CT examination showed a significant correlation with HDA% in the posteromedial region (p = 0.032). CONCLUSIONS: Subchondral bone density in the posteromedial region significantly increased after ACL injury and correlated with the duration of ACL-deficiency in semi-log manner in meniscus intact knees. The increase in stress on the posteromedial region after ACL injury, which induces a change in the subchondral bone density, justifies early ACL reconstruction after ACL injury.

Medial closed-wedge distal femoral osteotomy with local bone grafts for large collapsed steroid-induced osteonecrosis of the lateral femoral condyle: A case report.
Takuma Kaibara, Eiji Kondo, Masatake Matsuoka, Koji Iwasaki, Tomohiro Onodera, Daisuke Momma, Norimasa Iwasaki
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 04 Aug. 2021, [Domestic magazines]
English

大腿骨顆間外側壁における骨密度分布 前十字靱帯の大腿骨付着部についての考察
菅原 悠太郎, 岩崎 浩司, 遠藤 香織, 菱村 亮介, 松原 新史, 松岡 正剛, 門間 太輔, 小野寺 智洋, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 95, 8, S1715, S1715, (公社)日本整形外科学会, Aug. 2021
Japanese

遠隔転移を有する四肢発生軟部肉腫症例において原発巣切除が生存に与える影響
松岡 正剛, 小野寺 智洋, 横田 勲, 岩崎 浩司, 松原 新史, 菱村 亮介, 近藤 英司, 岩崎 倫政
東日本整形災害外科学会雑誌, 33, 3, 383, 383, 東日本整形災害外科学会, Aug. 2021
Japanese

軟部肉腫患者において初診時脳転移発生に寄与するリスク因子の探索 米国SEERデータベースを用いた研究
糸賀 稜, 松岡 正剛, 小野寺 智洋, 横田 勲, 岩崎 浩司, 松原 新史, 菱村 亮介, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 95, 8, S1550, S1550, (公社)日本整形外科学会, Aug. 2021
Japanese

手指原発の悪性骨腫瘍の検討
池 翔太, 松岡 正剛, 小野寺 智洋, 横田 勲, 岩崎 浩司, 菱村 亮介, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 95, 8, S1557, S1557, (公社)日本整形外科学会, Aug. 2021
Japanese

関節リウマチ患者の下肢手術数の傾向と併存症発生に関する調査
糸賀 稜, 清水 智弘, 高橋 大介, 小野寺 智洋, 岩崎 倫政
東日本整形災害外科学会雑誌, 33, 3, 285, 285, 東日本整形災害外科学会, Aug. 2021
Japanese

炎症性マクロファージ由来細胞外小胞を介した軟骨変性メカニズムの解明
江畑 拓, Terkawi Alaa, 松前 元, 横田 隼一, Alhasan Hend, 清水 智弘, 高橋 大介, 本谷 和俊, 小野寺 智洋, 角家 健, 岩崎 倫政
日本整形外科学会雑誌, 95, 8, S1520, S1520, (公社)日本整形外科学会, Aug. 2021
Japanese

炎症性マクロファージ由来細胞外小胞を介した軟骨変性メカニズムの解明
江畑 拓, Terkawi Alaa, 松前 元, 横田 隼一, Alhasan Hend, 清水 智弘, 高橋 大介, 本谷 和俊, 小野寺 智洋, 角家 健, 岩崎 倫政
日本整形外科学会雑誌, 95, 8, S1520, S1520, (公社)日本整形外科学会, Aug. 2021
Japanese

遠隔転移を有する四肢発生軟部肉腫症例において原発巣切除が生存に与える影響
松岡 正剛, 小野寺 智洋, 横田 勲, 岩崎 浩司, 松原 新史, 菱村 亮介, 近藤 英司, 岩崎 倫政
東日本整形災害外科学会雑誌, 33, 3, 383, 383, 東日本整形災害外科学会, Aug. 2021
Japanese

軟部肉腫患者において初診時脳転移発生に寄与するリスク因子の探索 米国SEERデータベースを用いた研究　　　　　　　　　　　　　　　
糸賀 稜, 松岡 正剛, 小野寺 智洋, 横田 勲, 岩崎 浩司, 松原 新史, 菱村 亮介, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 95, 8, S1550, S1550, (公社)日本整形外科学会, Aug. 2021
Japanese

手指原発の悪性骨腫瘍の検討　　　　　　　　　　　　　　　
池 翔太, 松岡 正剛, 小野寺 智洋, 横田 勲, 岩崎 浩司, 菱村 亮介, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 95, 8, S1557, S1557, (公社)日本整形外科学会, Aug. 2021
Japanese

関節リウマチ患者の下肢手術数の傾向と併存症発生に関する調査　　　　　　　　　　　　　　　
糸賀 稜, 清水 智弘, 高橋 大介, 小野寺 智洋, 岩崎 倫政
東日本整形災害外科学会雑誌, 33, 3, 285, 285, 東日本整形災害外科学会, Aug. 2021
Japanese

Delayed Onset of Infectious Foreign Body Granuloma for Nonabsorbable Sutures After Open Achilles Tendon Repair: A Case Report.
Ryo Itoga, Masatake Matsuoka, Tomohiro Onodera, Ai Shimizu, Koji Iwasaki, Shinji Matsubara, Ryosuke Hishimura, Eiji Kondo, Norimasa Iwasaki
The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons, 60, 6, 1297, 1300, 20 Jul. 2021, [International Magazine]
English, Foreign body granulomas from sutures are more common among non-absorbable sutures compared to absorbable sutures and have been reported as a postoperative complication in a variety of medical fields. However, only a few cases of delayed foreign body reaction have been reported and addressed with orthopedics. We present a patient with systemic lupus erythematosus who developed an infectious suture granuloma that extended to the entire Achilles tendon and was induced by nonabsorbable sutures that were used for open Achilles tendon repair 20 years before. This granuloma was resistant to antibiotic treatment and drainage and required surgical intervention. The tumor was marginally resected, and the continuity of the Achilles tendon was preserved. Histopathological examination detected many suture materials surrounded by xanthochromic necrotic lesions and the lesion was diagnosed as a foreign body granuloma. At 1 year after the operation, the patient did not exhibit exacerbation of infection or recurrence of the tumor, and she became able to walk by herself. To the best of our knowledge, this represents the first report of an infectious delayed foreign body granuloma in autoimmune disorder patient after open Achilles tendon repair. Surgical intervention should be considered, as treatment with conservative therapy such as antibiotics may be difficult.

初診時遠隔転移を有する四肢発生軟部肉腫症例における原発巣切除の意義 米国SEERデータベースを用いた研究
松岡 正剛, 小野寺 智洋, 横田 勲, 岩崎 浩司, 松原 新史, 菱村 亮介, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 95, 6, S1266, S1266, (公社)日本整形外科学会, Jun. 2021
Japanese

軟部肉腫患者において初診時脳転移発生に寄与するリスクファクターの検討 米国SEERデータベースを用いた研究
糸賀 稜, 松岡 正剛, 小野寺 智洋, 横田 勲, 岩崎 浩司, 松原 新史, 菱村 亮介, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 95, 6, S1314, S1314, (公社)日本整形外科学会, Jun. 2021
Japanese

遠隔転移を有する脊椎発生悪性骨腫瘍において原発巣切除は生存を改善するか
松岡 正剛, 小野寺 智洋, 横田 勲, 岩崎 浩司, 菱村 亮介, 岩田 玲, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 95, 6, S1348, S1348, (公社)日本整形外科学会, Jun. 2021
Japanese

四肢原発骨・軟部肉腫症例における患肢温存術と切断術の比較 米国SEERデータベースを用いた研究
中條 誠也, 松岡 正剛, 小野寺 智洋, 横田 勲, 岩崎 浩司, 菱村 亮介, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 95, 6, S1359, S1359, (公社)日本整形外科学会, Jun. 2021
Japanese

手指原発の悪性骨腫瘍の特徴 米国SEERデータベースを用いた研究
池 翔太, 松岡 正剛, 小野寺 智洋, 横田 勲, 岩崎 浩司, 菱村 亮介, 近藤 英司, 岩崎 倫政
日本整形外科学会雑誌, 95, 6, S1396, S1396, (公社)日本整形外科学会, Jun. 2021
Japanese

Ultrapurified Alginate Gel Containing Bone Marrow Aspirate Concentrate Enhances Cartilage and Bone Regeneration on Osteochondral Defects in a Rabbit Model
Liang Xu, Atsushi Urita, Tomohiro Onodera, Ryosuke Hishimura, Takayuki Nonoyama, Masanari Hamasaki, Dawei Liang, Kentaro Homan, Jian Ping Gong, Norimasa Iwasaki
The American Journal of Sports Medicine, 036354652110141, 036354652110141, SAGE Publications, 01 Jun. 2021
Scientific journal, Ultrapurified alginate (UPAL) gel implantation has been demonstrated as effective in cartilage repair for osteochondral defects; however, cell transplantation within UPAL gels would be required to treat larger defects.

The combination of UPAL gel and bone marrow aspirate concentrate (BMAC) would enhance cartilage repair and subchondral bone repair for large osteochondral defects.

Controlled laboratory study.

A total of 104 osteochondral defects (1 defect per knee) of 52 rabbits were randomly divided into 4 groups (26 defects per group): defects without any treatment (Defect group), defects treated using UPAL gel alone (UPAL group), defects treated using UPAL gel containing allogenic bone marrow mesenchymal stromal cells (UPAL-MSC group), and defects treated using UPAL gel containing BMAC (UPAL-BMAC group). At 4 and 16 weeks postoperatively, macroscopic and histologic evaluations and measurements of repaired subchondral bone volumes of reparative tissues were performed. Collagen orientation and mechanical properties of the reparative tissue were assessed at 16 weeks.

The defects in the UPAL-BMAC group were repaired with hyaline-like cartilage with well-organized collagen structures. The histologic scores at 4 weeks were significantly higher in the UPAL-BMAC group (16.9 ± 2.0) than in the Defect group (4.7 ± 1.9; P < .05), the UPAL group (10.0 ± 3.3; P < .05), and the UPAL-MSC group (12.2 ± 2.9; P < .05). At 16 weeks, the score in the UPAL-BMAC group (24.4 ± 1.7) was significantly higher than those in the Defect group (9.0 ± 3.7; P < .05), the UPAL group (14.2 ± 3.9; P < .05), and the UPAL-MSC group (16.3 ± 3.6; P < .05). At 4 and 16 weeks, the macroscopic evaluations were significantly superior in the UPAL-BMAC group compared with the other groups, and the values of repaired subchondral bone volumes in the UPAL-BMAC group were significantly higher than those in the Defect and UPAL groups. The mechanical properties of the reparative tissues were significantly better in the UPAL-BMAC group than in the other groups.

The implantation of UPAL gel containing BMAC-enhanced hyaline-like cartilage repair and subchondral bone repair of osteochondral defects in a rabbit knee model.

These data support the potential clinical application of 1-step treatment for large osteochondral defects using biomaterial implantation with cell transplantation.

Effect of High Tibial Osteotomy on the Distribution of Subchondral Bone Density Across the Proximal Tibial Articular Surface of the Knee With Medial Compartment Osteoarthritis.
Koji Iwasaki, Eiji Kondo, Shinji Matsubara, Masatake Matsuoka, Kaori Endo, Isao Yokota, Tomohiro Onodera, Norimasa Iwasaki
The American journal of sports medicine, 49, 6, 1561, 1569, May 2021, [International Magazine]
English, Scientific journal, BACKGROUND: The effect of high tibial osteotomy (HTO) on the stress distribution across the knee joint is not completely understood. Subchondral bone density is considered to reflect the pattern of stress distribution across a joint surface. PURPOSE: To assess the distribution of subchondral bone density across the proximal tibia in nonarthritic knees and in the knees of patients with osteoarthritis (OA) before and after HTO. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: We retrospectively collected radiological and computed tomography data from 16 patients without OA (control group) and 17 patients with OA. Data from the OA group were collected before and 1.5 years after HTO. Subchondral bone density of the proximal tibia was assessed with computed tomography-osteoabsorptiometry. The locations and percentages represented by high-density areas (HDAs) on the articular surface were quantitatively analyzed. RESULTS: The ratio of the HDA of the medial compartment to the total HDA (medial ratio) was significantly higher in the preoperative OA group (mean, 80.1%) than in the control group (61.3%) (P < .001). After HTO, the medial ratio decreased significantly to 75.1% (P = .035 in comparison with preoperative values) and was significantly correlated with the hip-knee-ankle angle in both groups: control (r = -0.551; P = .033) and OA (r = -0.528; P = .043). The change in medial ratio after HTO was significantly correlated with the change in hip-knee-ankle angle (r = 0.587; P = .035). In the medial compartment, the HDA in the most lateral region of 4 subregions increased after HTO, but that in 3 medial subregions decreased. CONCLUSION: In this exploratory study, HTO shifted the HDA of the medial compartment of the proximal tibial articular surface toward the lateral compartment. In contrast, the HDA of the most lateral region of the medial compartment increased after HTO. This change in subchondral bone density may result from the change in stress distribution.

Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis
Taku Ebata, Mohamad Alaa Terkawi, Masanari Hamasaki, Gen Matsumae, Tomohiro Onodera, Mahmoud Khamis Aly, Shunichi Yokota, Hend Alhasan, Tomohiro Shimizu, Daisuke Takahashi, Kentaro Homan, Ken Kadoya, Norimasa Iwasaki
iScience, 102643, 102643, Elsevier BV, May 2021
Scientific journal

Changes in the Contact Stress Distribution Pattern of the Patellofemoral Joint After Medial Open-Wedge High Tibial Osteotomy: An Evaluation Using Computed Tomography Osteoabsorptiometry.
Toshiaki Kameda, Eiji Kondo, Tomohiro Onodera, Koji Iwasaki, Jun Onodera, Kazunori Yasuda, Norimasa Iwasaki
Orthopaedic journal of sports medicine, 9, 4, 2325967121998050, 2325967121998050, Apr. 2021, [International Magazine]
English, Scientific journal, Background: Medial open-wedge high tibial osteotomy (OWHTO) theoretically causes distalization and lateralization of the tibial tuberosity and the patella. Purpose/Hypothesis: The purpose of the study was to identify any changes in the stress distribution of subchondral bone density across the patellofemoral (PF) joint before and after OWHTO through the use of computed tomography (CT) osteoabsorptiometry. We hypothesized that OWHTO would alter the distribution of contact stress in the PF joint. Study Design: Case series; Level of evidence, 4. Methods: A total of 17 patients (17 knees) who underwent OWHTO were enrolled in this study between September 2013 and September 2015. All patients underwent radiologic examination preoperatively and at 1 year postoperatively, and the distribution patterns of subchondral bone density through the articular surface of the femoral trochlea and patella were assessed preoperatively and >1 year postoperatively using CT osteoabsorptiometry. The quantitative analysis of the obtained mapping data focused on location of the high-density area (HDA) through the articular surface of the PF joint. The percentage of HDA at each divided region of the articular surface of the femoral trochlea and the patella was calculated. Results: In the radiologic evaluation, the Blackburne-Peel ratio was significantly reduced (P < .001) after surgery, and the tilting angle of the patella was significantly decreased (P < .001). On CT evaluation, the percentage of HDA in the lateral notch and lateral trochlea of the femur and in the medial portion of the lateral facet of the patella increased significantly after OWHTO surgery (P ≤ .038). Conclusion: OWHTO significantly increased the stress distribution pattern of the lateral trochlea of the femur and the medial portion of the lateral facet of the patella. The procedure significantly lowered the patellar height and significantly decreased the patellar tilting angle after surgery.

Local Administration of Low-Dose Nerve Growth Factor Antibody Reduced Pain in a Rat Osteoarthritis Model.
Yuan Tian, Tomohiro Onodera, Mohamad Alaa Terkawi, Koji Iwasaki, Ryosuke Hishimura, Dawei Liang, Takuji Miyazaki, Norimasa Iwasaki
International journal of molecular sciences, 22, 5, 04 Mar. 2021, [International Magazine]
English, Scientific journal, Systemic injection of a nerve growth factor (NGF) antibody has been proven to have a significant relevance in relieving osteoarthritis (OA) pain, while its adverse effects remain a safety concern for patients. A local low-dose injection is thought to minimize adverse effects. In this study, OA was induced in an 8-week-old male Sprague-Dawley (SD) rat joint by monoiodoacetate (MIA) injection for 2 weeks, and the effect of weekly injections of low-dose (1, 10, and 100 µg) NGF antibody or saline (control) was evaluated. Behavioral tests were performed, and at the end of week 6, all rats were sacrificed and their knee joints were collected for macroscopic and histological evaluations. Results showed that 100 µg NGF antibody injection relieved pain in OA rats, as evidenced from improved weight-bearing performance but not allodynia. In contrast, no significant differences were observed in macroscopic and histological scores between rats from different groups, demonstrating that intra-articular treatment does not worsen OA progression. These results suggest that local administration yielded a low effective NGF antibody dose that may serve as an alternative approach to systemic injection for the treatment of patients with OA.

Acellular Cartilage Repair Technique Based on Ultrapurified Alginate Gel Implantation for Advanced Capitellar Osteochondritis Dissecans
Daisuke Momma, Tomohiro Onodera, Daisuke Kawamura, Atsushi Urita, Yuichiro Matsui, Rikiya Baba, Tadanao Funakoshi, Makoto Kondo, Toshiya Endo, Eiji Kondo, Norimasa Iwasaki
Orthopaedic Journal of Sports Medicine, 9, 3, 232596712198967, 232596712198967, SAGE Publications, 01 Mar. 2021
Scientific journal, One of the most important limitations of osteochondral autograft transplant is the adverse effect on donor sites in the knee. Ultrapurified alginate (UPAL) gel is a novel biomaterial that enhances hyaline-like cartilage repair for articular defects. To avoid the need for knee cartilage autografting when treating osteochondritis dissecans (OCD) of the capitellum, we developed a surgical procedure involving a bone marrow stimulation technique (BMST) augmented by implantation of UPAL gel.

BMST augmented by UPAL gel implantation improves the cartilage repair capacity and provides satisfactory clinical outcomes in OCD of the capitellum.

Case series; Level of evidence, 4.

A total of 5 athletes with advanced capitellar OCD in the dominant elbow underwent BMST augmented by implantation of UPAL gel. The osteochondral defects were filled with UPAL gel after BMST. At a mean follow-up of 97 weeks, all patients were evaluated clinically and radiographically.

At final follow-up, all 5 patients had returned to competitive-level sports, and 4 patients were free from elbow pain. The mean Timmerman-Andrews score significantly improved from 100 to 194 points. Radiographically, all patients exhibited graft incorporation and a normal contour of the subchondral cortex. Magnetic resonance imaging showed that the preoperative heterogeneity of the lesion had disappeared, and the signal intensity had returned to normal. Arthroscopic examinations consistently exhibited improvement in the International Cartilage Regeneration and Joint Preservation Society (ICRS) grade of lesions from 3 or 4 to 1 or 2 in 4 patients at 85 weeks postoperatively. Histologic analysis of biopsy specimens revealed an average total ICRS Visual Assessment Scale II histologic score of 1060.

The acellular cartilage repair technique using UPAL gel for advanced capitellar OCD provided satisfactory clinical and radiographic results. The present results suggest that this novel technique is a useful, minimally invasive approach for treating cartilaginous lesions in athletes.

関節リウマチ患者の下肢手術数の傾向と併存症発生に関する調査　　　　　　　　　　　　　　　
糸賀 稜, 清水 智弘, 高橋 大介, 小野寺 智洋, 岩崎 倫政
日本リウマチ学会北海道・東北支部学術集会抄録集, 30回, 45, 45, (一社)日本リウマチ学会-北海道・東北支部, Feb. 2021
Japanese

大腿骨顆間窩外側壁における骨密度分布 前十字靱帯の大腿骨付着部に関する考察
菅原 悠太郎, 遠藤 香織, 菱村 亮介, 松原 新史, 松岡 正剛, 小野寺 智洋, 岩崎 倫政, 岩崎 浩司, 門間 大輔, 近藤 英司
北海道整形災害外科学会雑誌, 63, 139th suppl, 36, 36, 北海道整形災害外科学会, 2021
Japanese

Hallux Valgus With Second Brachymetatarsia Discovered Accidentally: A Case Report.
Shinji Matsubara, Tomohiro Onodera, Koji Iwasaki, Ryosuke Hishimura, Masatake Matsuoka, Eiji Kondo, Norimasa Iwasaki
The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons, 60, 5, 1060, 1062, 2021, [International Magazine]
English, Hallux valgus deformity is one of the most common foot and ankle diseases, while brachymetatarsia is a rare foot anomaly with pathological shortening of a metatarsal bone. We present a case of hallux valgus deformity possibly due to second brachymetatarsia. As the hallux valgus was associated with dorsal dislocation of the second toe that made it difficult to evaluate the length of the second toe, the patient was unaware of the second metatarsal shortening until the lengths of the toes compared by manual reposition of the second MTP joint. In this case, proximal osteotomy of the first metatarsal on the hallux valgus and single-stage bone lengthening of the second metatarsal with iliac bone grafting on the second brachymetatarsia were performed. One year after the operation, the callosity of the third toe resolved and the clinical scores were improved. In the case of a hallux valgus deformity with second dorsal dislocation of the toes, surgeons should consider that there are rare cases with second metatarsal shortening. When hallux valgus associated with second brachymetatarsia is diagnosed, second metatarsal lengthening should be considered in addition to hallux valgus surgery.

Impact of Smoking History on Pulmonary Metastasis-free Survival in Patients With Soft-tissue Sarcoma.
Masatake Matsuoka, Masanori Okamoto, Tamotsu Soma, Isao Yokota, Ryuta Arai, Tomohiro Onodera, Eiji Kondo, Norimasa Iwasaki, Hiroaki Hiraga
Cancer diagnosis & prognosis, 1, 2, 89, 94, 2021, [International Magazine]
English, Scientific journal, BACKGROUND/AIM: Although smoking history is predictive of poor pulmonary metastasis-free survival (PMFS) in patients with epithelial tumors, the impact of smoking history on PMFS in those with soft-tissue sarcoma (STS) is not known. PATIENTS AND METHODS: Patients undergoing treatment for STS at our institutes between 2008 and 2017 were enrolled. Patients were excluded if they had metastatic lesion, or had a histopathological classification demonstrating small round-cell sarcoma. The impact of smoking history on PMFS and overall survival was examined with multivariate analysis using a Cox proportional hazards model. RESULTS: A total of 250 patients were retrospectively reviewed. Patients with smoking history had worse PMFS on multivariate analysis (hazard ratio=2.00, 95% confidence interval=1.12-3.60). On the other hand, smoking history did not significantly affect overall survival (hazard ratio=1.26, 95% confidence interval=0.61-2.58). CONCLUSION: Patients with STS need to be followed-up by frequent clinical assessments if they have a smoking history.

非円形軟部肉腫症例において喫煙歴は肺転移発生の危険因子である
松岡 正剛, 相馬 有, 新井 隆太, 平賀 博明, 小野寺 智洋, 岩崎 倫政, 横田 勲, 近藤 英司
北海道整形災害外科学会雑誌, 63, 139th suppl, 19, 19, 北海道整形災害外科学会, 2021
Japanese

アキレス腱縫合術20年後に発症した腱縫合糸に対する感染性異物性肉芽腫の1例
糸賀 稜, 松岡 正剛, 小野寺 智洋, 松原 新史, 菱村 亮介, 岩崎 倫政, 清水 亜衣, 岩崎 浩司, 近藤 英司
北海道整形災害外科学会雑誌, 63, 139th suppl, 79, 79, 北海道整形災害外科学会, 2021
Japanese

Angiosarcoma after revision total knee arthroplasty.
Ryuichi Fukuda, Masatake Matsuoka, Tomohiro Onodera, Koji Iwasaki, Daisuke Tanaka, Hiroaki Hiraga, Hiromi Kanno-Okada, Yoshihiro Matsuno, Eiji Kondo, Norimasa Iwasaki
The Knee, 28, 151, 158, Jan. 2021, [International Magazine]
English, BACKGROUND: Hemarthrosis after total knee arthroplasty (TKA) is a relatively rare complication. Although most cases are effectively treated with conservative therapy, some cases require angiographic embolization or surgical intervention. Angiosarcoma is a rare malignant tumor derived from the vascular endothelium with neovascular hyperplasia and mainly arises in the skin and superficial soft tissue, and less frequently in deep soft tissue and bone. Although malignant neoplasms such as angiosarcoma in the vicinity of orthopedic implants were reported, the causal relationship between development of the malignant tumor and the orthopedic implant is widely debated in the literature. CASE PRESENTATION: We report the case of a 68-year-old female with angiosarcoma that developed in the knee joint 2 years after revision TKA. The patient exhibited severe persistent bleeding, which reached 1000-1400 ml per day for 4 months. Histological analysis of the synovial tissue in the knee joint showed large cells with nuclear atypia. Immunohistochemical staining showed cells that were positive for CD31, CD34, and D2-40, and she was diagnosed with angiosarcoma. The patient underwent an amputation at the level of the thigh, and her general condition immediately improved after the operation. The patient did not exhibit bleeding from the site of amputation, and no local recurrence or distant metastases were detected 1 year after the amputation. CONCLUSIONS: To the best of our knowledge, this represents the first report of angiosarcoma 2 years after revision TKA. Further careful follow up is needed, given the high-grade malignancy.

関節リウマチ患者の下肢手術件数の傾向と併存症発生に関する調査
糸賀 稜, 清水 智弘, 高橋 大介, 小野寺 智洋, 岩崎 倫政
北海道整形災害外科学会雑誌, 63, 139th suppl, 44, 44, 北海道整形災害外科学会, 2021
Japanese

摩耗軟骨片活性化マクロファージにより軟骨細胞に発現上昇するFlightless Iの機能解析
江畑 拓, テルカウイ・アラー, 松前 元, 横田 隼一, アルハサン・ヘンド, 濱崎 雅成, 清水 智弘, 高橋 大介, 小野寺 智洋, 岩崎 倫政
北海道整形災害外科学会雑誌, 63, 139th suppl, 63, 63, 北海道整形災害外科学会, 2021
Japanese

変形性膝関節症症例におけるウェアラブルセンサーを用いた歩行評価時の最適なセンサー貼付位置の検討
佐橋 健人, 千葉 健, 岩崎 浩司, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 遠山 晴一
北海道整形災害外科学会雑誌, 63, 139th suppl, 35, 35, 北海道整形災害外科学会, 2021
Japanese

Alterations of Glycosphingolipid Glycans and Chondrogenic Markers during Differentiation of Human Induced Pluripotent Stem Cells into Chondrocytes.
Liang Xu, Hisatoshi Hanamatsu, Kentaro Homan, Tomohiro Onodera, Takuji Miyazaki, Jun-Ichi Furukawa, Kazutoshi Hontani, Yuan Tian, Rikiya Baba, Norimasa Iwasaki
Biomolecules, 10, 12, 01 Dec. 2020, [International Magazine]
English, Scientific journal, Due to the limited intrinsic healing potential of cartilage, injury to this tissue may lead to osteoarthritis. Human induced pluripotent stem cells (iPSCs), which can be differentiated into chondrocytes, are a promising source of cells for cartilage regenerative therapy. Currently, however, the methods for evaluating chondrogenic differentiation of iPSCs are very limited; the main techniques are based on the detection of chondrogenic genes and histological analysis of the extracellular matrix. The cell surface is coated with glycocalyx, a layer of glycoconjugates including glycosphingolipids (GSLs) and glycoproteins. The glycans in glycoconjugates play important roles in biological events, and their expression and structure vary widely depending on cell types and conditions. In this study, we performed a quantitative GSL-glycan analysis of human iPSCs, iPSC-derived mesenchymal stem cell like cells (iPS-MSC like cells), iPS-MSC-derived chondrocytes (iPS-MSC-CDs), bone marrow-derived mesenchymal stem cells (BMSCs), and BMSC-derived chondrocytes (BMSC-CDs) using glycoblotting technology. We found that GSL-glycan profiles differed among cell types, and that the GSL-glycome underwent a characteristic alteration during the process of chondrogenic differentiation. Furthermore, we analyzed the GSL-glycome of normal human cartilage and found that it was quite similar to that of iPS-MSC-CDs. This is the first study to evaluate GSL-glycan structures on human iPS-derived cartilaginous particles under micromass culture conditions and those of normal human cartilage. Our results indicate that GSL-glycome analysis is useful for evaluating target cell differentiation and can thus support safe regenerative medicine.

摩耗軟骨片による滑膜炎が誘導する軟骨細胞新規分泌因子「Flightless I」の機能解析
江畑 拓, Terkawi Alaa, 小野寺 智洋, 木田 博朗, 松前 元, 田 園, Alhasan Hend, 濱崎 雅成, 清水 智弘, 高橋 大介, 岩崎 倫政
日本整形外科学会雑誌, 94, 8, S1690, S1690, (公社)日本整形外科学会, Sep. 2020
Japanese

ヒトiPS細胞の軟骨分化誘導過程におけるスフィンゴ糖脂質糖鎖の網羅的発現解析
徐 亮, 花松 久寿, 宝満 健太郎, 小野寺 智洋, 古川 潤一, 本谷 和俊, 宮崎 拓自, 田 園, 岩崎 倫政
日本整形外科学会雑誌, 94, 8, S1815, S1815, (公社)日本整形外科学会, Sep. 2020
Japanese

細胞特異的糖鎖解析による残存未分化iPS細胞の定量的評価法の確立
宮崎 拓自, 花松 久寿, 小野寺 智洋, 徐 亮, 古川 潤一, 宝満 健太郎, 川嵜 敏祐, 岩崎 倫政
日本整形外科学会雑誌, 94, 8, S1874, S1874, (公社)日本整形外科学会, Sep. 2020
Japanese

関節軟骨におけるフコシル化糖鎖の欠損は可逆的修復を阻害し軟骨変性を進行させる
宝満 健太郎, 小野寺 智洋, 古川 潤一, 花松 久寿, 濱崎 雅成, 徐 亮, 宮崎 拓自, 細川 吉暁, 岩崎 倫政
日本整形外科学会雑誌, 94, 8, S1970, S1970, (公社)日本整形外科学会, Sep. 2020
Japanese

ヒトiPS細胞の軟骨分化誘導過程におけるスフィンゴ糖脂質糖鎖の網羅的発現解析　　　　　　　　　　　　　　　
徐 亮, 花松 久寿, 宝満 健太郎, 小野寺 智洋, 古川 潤一, 本谷 和俊, 宮崎 拓自, 田 園, 岩崎 倫政
日本整形外科学会雑誌, 94, 8, S1815, S1815, (公社)日本整形外科学会, Sep. 2020
Japanese

細胞特異的糖鎖解析による残存未分化iPS細胞の定量的評価法の確立　　　　　　　　　　　　　　　
宮崎 拓自, 花松 久寿, 小野寺 智洋, 徐 亮, 古川 潤一, 宝満 健太郎, 川嵜 敏祐, 岩崎 倫政
日本整形外科学会雑誌, 94, 8, S1874, S1874, (公社)日本整形外科学会, Sep. 2020
Japanese

関節軟骨におけるフコシル化糖鎖の欠損は可逆的修復を阻害し軟骨変性を進行させる　　　　　　　　　　　　　　　
宝満 健太郎, 小野寺 智洋, 古川 潤一, 花松 久寿, 濱崎 雅成, 徐 亮, 宮崎 拓自, 細川 吉暁, 岩崎 倫政
日本整形外科学会雑誌, 94, 8, S1970, S1970, (公社)日本整形外科学会, Sep. 2020
Japanese

Large osteochondral defect in the lateral femoral condyle reconstructed by Atelocollagen-associated autologous chondrocyte implantation combined with anterior cruciate ligament reconstruction.
Takuma Kaibara, Eiji Kondo, Masatake Matsuoka, Koji Iwasaki, Tomohiro Onodera, Daisuke Momma, Naoki Seito, Susumu Mikami, Norimasa Iwasaki
BMC musculoskeletal disorders, 21, 1, 494, 494, 27 Jul. 2020, [International Magazine]
English, Scientific journal, BACKGROUND: Articular surface damage commonly associated with rupture of the anterior cruciate ligament (ACL). Large osteochondral defect, which consists of a severe depression fracture and a large cartilage defect, need to be treated due to deformation of the articular surface as it can impact the clinical outcome of ACL reconstruction. Although autologous chondrocyte implantation is one of the useful options in such cases, it can be questioned whether the reconstruction of the ACL and osteochondral defect should be performed in one procedure alone. CASE PRESENTATION: We report a case of a 38-year-old male with a deep depression fracture extending to the edge of the lateral femoral condyle associated with ACL injury after twisting his right knee while skiing. The patient was successfully treated with tissue-engineered cartilage transplantation covered by the periosteum with an iliac bone graft combined with anatomic double-bundle ACL reconstruction. Histopathological examination of the transplanted cartilage taken at second-look arthroscopy showed a cartilage-like tissue in the middle to deep zone in which the extracellular matrix was largely stained with Safranin O. The patient was able to return to his previous level of skiing activity without any experience of knee pain. Magnetic resonance imaging at 4 years after surgery showed that the graft integrated to the border zone and subchondral bone. The operated knee showed negative Lachman test and had a full range of motion. CONCLUSIONS: To our knowledge, this is the first report of anatomic double-bundle ACL reconstruction with tissue-engineered cartilage transplantation and an iliac bone graft to restore the lateral edge of the femoral condyle.

Role of Chondrocytes in the Development of Rheumatoid Arthritis Via Transmembrane Protein 147-Mediated NF-κB Activation.
Mitsutoshi Ota, Yuki Tanaka, Ikuma Nakagawa, Jing-Jing Jiang, Yasunobu Arima, Daisuke Kamimura, Tomohiro Onodera, Norimasa Iwasaki, Masaaki Murakami
Arthritis & rheumatology (Hoboken, N.J.), 72, 6, 931, 942, Jun. 2020, [International Magazine]
English, Scientific journal, OBJECTIVE: We have previously reported that the coactivation of NF-κB and STAT3 in nonimmune cells, including synovial fibroblasts, enhances the expression of NF-κB target genes and plays a role in chronic inflammation and rheumatoid arthritis (RA). This study was undertaken to examine the role of NF-κB activation in chondrocytes and better understand the pathogenesis of RA. Furthermore, transmembrane protein 147 (TMEM147) was investigated as a representative NF-κB activator in chondrocytes. METHODS: Clinical samples from RA patients were analyzed by immunohistochemistry. Specimens obtained from patients with polydactyly were used as control samples. The functional contribution of chondrocytes and TMEM147 to arthritis was examined in several murine models of RA. In vitro experiments (quantitative polymerase chain reaction, RNA interference, immunoprecipitation, and confocal microscopy) were performed to investigate the mechanism of action of TMEM147 in chondrocytes. RESULTS: Samples obtained from RA patients and mouse models of RA showed coactivation of NF-κB and STAT3 in chondrocytes (P < 0.001). This coactivation induced a synergistic expression of NF-κB targets in vitro (P < 0.01). Chondrocyte-specific deletion of STAT3 significantly suppressed the development of cytokine-induced RA (P < 0.01). TMEM147 was highly expressed in chondrocytes from RA patient samples and the mouse models of RA. Gene silencing of TMEM147 or anti-TMEM147 antibody treatment inhibited the cytokine-mediated activation of NF-κB in vitro (P < 0.01) and suppressed cytokine-induced RA in vivo (P < 0.01). Mechanistically, TMEM147 molecules acted as scaffold proteins for the NF-κB complex, which included breakpoint cluster region and casein kinase 2, and enhanced NF-κB activity. CONCLUSION: These results suggest that chondrocytes play a role in the development of RA via TMEM147-mediated NF-κB activation and indicate a novel therapeutic strategy for RA.

Therapeutic effects and adaptive limits of an acellular technique by ultrapurified alginate (UPAL) gel implantation in canine osteochondral defect models.
Tomohiro Onodera, Rikiya Baba, Yasuhiko Kasahara, Toshihiko Tsuda, Norimasa Iwasaki
Regenerative therapy, 14, 154, 159, Jun. 2020, [International Magazine]
English, Scientific journal, Background: The aim of this study was to clarify the objective therapeutic effects of an acellular technique by ultrapurified alginate (UPAL) gel implantation in canine osteochondral defect models. Methods: Two osteochondral defects (diameters: 3.0 and 5.0 mm) were created on each patellar groove in both knees of 10 dogs. Defects were divided into four groups (n = 10 each): Group 1, untreated 3.0-mm defect; Group 2, 3.0-mm defect with UPAL gel; Group 3, untreated 5.0-mm defect; and Group 4, 5.0-mm defect with UPAL gel. All surgical procedures were performed by individuals unfamiliar with the technique at an independent institution. Articular surfaces were evaluated grossly and histologically at 27 weeks after operation. Results: UPAL gel-treated osteochondral defects showed significantly improved gross appearance in Group 4 and histological appearance in Groups 2 and 4. Reparative tissues in the 3.0-mm defect with UPAL gel were replaced by hyaline-like cartilage tissue. The 5.0-mm defects with UPAL gel were mostly covered with fibrocartilaginous tissue, whereas UPAL gel-untreated defects mostly remained uncovered by any tissue. Conclusions: Although an acellular technique using UPAL gel implantation significantly enhanced osteochondral repair in canines, reparative tissues of the large defect with alginate gel comprised of fibrocartilaginous tissue. This surgical technique is effective, especially for small cartilage injuries. Further improvements are required before clinical application in cases of severe osteochondral defects in humans.

Clinical Outcomes and Complications During and After Medial Open-Wedge High Tibial Osteotomy Using a Locking Plate: A 3- to 7-Year Follow-up Study.
Koji Yabuuchi, Eiji Kondo, Jun Onodera, Tomohiro Onodera, Tomonori Yagi, Norimasa Iwasaki, Kazunori Yasuda
Orthopaedic journal of sports medicine, 8, 6, 2325967120922535, 2325967120922535, Jun. 2020, [International Magazine]
English, Scientific journal, Background: Outcomes and complications at mid- or long-term follow-up after medial open-wedge high tibial osteotomy (MOWHTO) with the TomoFix locking plate have not been fully evaluated. Purpose: To evaluate the complications and midterm clinical outcomes after MOWHTO using a TomoFix. Study Design: Case series; Level of evidence, 4. Methods: Enrolled in this study were 80 patients (85 knees) who underwent MOWHTO with the TomoFix locking plate between 2009 and 2013. There were 66 women and 14 men, with a mean age of 61.5 years at the time of surgery. The diagnosis was medial osteoarthritis in 76 knees and spontaneous osteonecrosis of the knee in 9 knees. Metal removal and second-look arthroscopy were performed in all cases. Clinical and radiological examinations were performed at final follow-up after surgery (mean, 4.5 years). Results: The mean Japanese Orthopaedic Association score and Knee injury and Osteoarthritis Outcome Score improved significantly from pre- to postoperatively (P < .0001). The weightbearing line percentage shifted to pass through a point 67.7% lateral from the medial edge of the tibial plateau. The Caton-Deschamps index changed significantly from 0.88 to 0.66 at final follow-up (P < .0001). The mean posterior tibial slope changed significantly from 8.9° to 11.9° at final follow-up (P < .0001). Limb length was significantly increased after MOWHTO (10.3 mm; P < .0001). During plate removal, 14 locking screws were found to be broken in 9 knees (10.6%). The articular cartilage grade of the patellofemoral joint was significantly higher in the second arthroscopy than in the first arthroscopy (P < .0001). The cumulative rate of all complications was 41.2%, with major complications (ie, those requiring additional or extended treatment) in 24.7%. Conclusion: Postoperative outcome scores indicated significant improvement after MOWHTO, although the cumulative rate of all complications was 41.2% and the rate of major complications was 24.7%. These results indicate that MOWHTO with the TomoFix is a technically demanding procedure. Careful preoperative planning and meticulous surgical technique are needed to decrease the incidence of complications associated with MOWHTO.

Transcriptional profiling of murine macrophages stimulated with cartilage fragments revealed a strategy for treatment of progressive osteoarthritis.
Masanari Hamasaki, Mohamad Alaa Terkawi, Tomohiro Onodera, Yuan Tian, Taku Ebata, Gen Matsumae, Hend Alhasan, Daisuke Takahashi, Norimasa Iwasaki
Scientific reports, 10, 1, 7558, 7558, 05 May 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, Accumulating evidence suggests that synovitis is associated with osteoarthritic process. Macrophages play principal role in development of synovitis. Our earlier study suggests that interaction between cartilage fragments and macrophages exacerbates osteoarthritic process. However, molecular mechanisms by which cartilage fragments trigger cellular responses remain to be investigated. Therefore, the current study aims at analyzing molecular response of macrophages to cartilage fragments. To this end, we analyzed the transcriptional profiling of murine macrophages exposed to cartilage fragments by RNA sequencing. A total 153 genes were differentially upregulated, and 105 genes were down-regulated in response to cartilage fragments. Bioinformatic analysis revealed that the most significantly enriched terms of the upregulated genes included scavenger receptor activity, integrin binding activity, TNF signaling, and toll-like receptor signaling. To further confirm our results, immunohistochemical staining was performed to detected regulated molecules in synovial tissues of OA patients. In consistence with RNA-seq results, MARCO, TLR2 and ITGα5 were mainly detected in the intima lining layer of synovial tissues. Moreover, blockade of TLR2 or ITGα5 but not Marco using specific antibody significantly reduced production of TNF-α in stimulated macrophages by cartilage fragments. Our data suggested that blocking TLR2 or ITGα5 might be promising therapeutic strategy for treating progressive osteoarthritis.

Autophagy promotes citrullination of VIM (vimentin) and its interaction with major histocompatibility complex class II in synovial fibroblasts.
Eri Sugawara, Masaru Kato, Yuki Kudo, Wenshi Lee, Ryo Hisada, Yuichiro Fujieda, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Shinsuke Yasuda, Tomohiro Onodera, Shigetsugu Hatakeyama, Tatsuya Atsumi
Autophagy, 16, 5, 946, 955, May 2020, [International Magazine]
English, Scientific journal, We aimed to investigate the involvement of macroautophagy/autophagy in autoimmunity in rheumatoid arthritis (RA) through citrullination of VIM (vimentin) and its interaction with MHC class II in synovial fibroblasts (SFs). The cell surface expression of MHC class II and B7 costimulatory molecules on SFs was analyzed by flow cytometry after treatment with IFNG/IFN-γ (interferon gamma). Intracellular citrullinated autoantigens in SFs were analyzed by immunoblotting using serum from anti-citrullinated peptide antibodies (ACPA)-positive patient as a primary antibody. SFs were incubated in serum-free medium or treated with proteasome inhibitor MG132 to induce autophagy. An autophagy inhibitor 3-methyladenin (3-MA) was used. Intracellular citrullinated VIM (cVIM) was evaluated by immunoblotting and immunocytochemistry. The interaction between MHC class II and cVIM was evaluated with co-immunoprecipitation and proximity ligation assay (PLA). We demonstrated that MHC class II, CD274/B7-H1 and PDCD1LG2/B7-DC were expressed on SFs following treatment with IFNG whereas CD276/B7-H3 was detected on SFs regardless of the presence of IFNG. ACPA-positive sera recognized a 54 kDa protein in SFs. By immunoprecipitation, the 54 kDa protein recognized by RA sera was revealed to be cVIM. Following induction of autophagy, intracellular cVIM was increased in SFs but the effect was canceled by 3-MA. The interaction between MHC class II and cVIM was demonstrated by co-immunoprecipitation. Furthermore, PLA revealed the significant increase of MHC class II-cVIM interaction following induction of autophagy. Our findings suggest that SFs may contribute to the autoimmunity in RA through citrullination of VIM and its interaction with MHC class II promoted by autophagy.Abbreviations: 3-MA: 3-methyladenine; ACPA: anti-citrullinated peptide antibodies; anti-CCP: anti-cyclic citrullinated peptide antibody; cVIM: citrullinated VIM; BECN1: beclin1; DAPI: 4',6-diamidino-2-phenylindole; FBS: fetal bovine serum; HLA: human leukocyte antigen; IFNG/IFN-γ: interferon gamma; IL6: interleukin 6; IP: immunoprecipitation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFI: mean fluorescence index; MHC: major histocompatibility complex; OA: osteoarthritis; PADI: peptidyl arginine deiminase; PepA: pepstatin A; PBS: phosphate-buffered saline; PtdIns3K: phosphatidylinositol 3-kinase; RA: rheumatoid arthritis; SFs: synovial fibroblasts; siRNA: small interfering RNA; VIM: vimentin.

Which Contributes to Meniscal Repair, the Synovium or the Meniscus? An In Vivo Rabbit Model Study With the Freeze-Thaw Method.
WooYoung Kim, Tomohiro Onodera, Eiji Kondo, Mohamad Alaa Terkawi, Kentaro Homan, Ryosuke Hishimura, Norimasa Iwasaki
The American journal of sports medicine, 48, 6, 1406, 1415, May 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: During meniscal tissue repair, the origin of the reparative cells of damaged meniscal tissue remains unclear. HYPOTHESIS: Comparison of the influence between meniscal and synovial tissues on meniscal repair by the in vivo freeze-thaw method would clarify the origin of meniscal reparative cells. STUDY DESIGN: Controlled laboratory study. METHODS: A total of 48 mature Japanese white rabbits were divided into 4 groups according to the tissue (meniscal or synovial) that received freeze-thaw treatment. The meniscus of each group had a 2 mm-diameter cylindrical defect filled with alginate gel. Macroscopic and histologic evaluations of the reparative tissues were performed at 1, 3, and 6 weeks postoperatively. Additional postoperative measurements included cell density, which was the number of meniscal cells in the cut area per cut area (mm2) of meniscus; cell density ratio, which was the cell density of the sample from each group per the average cell density of the intact meniscus; and cell death rate, which was the number of cells stained by propidium iodide per the number of cells stained by Hoechst 33342 of the meniscal tissue adjacent to the defect. RESULTS: The macroscopic and histologic evaluations of the non-synovium freeze-thaw groups were significantly superior to those of the synovium freeze-thaw groups at 3 and 6 weeks postoperatively. Additionally, the meniscal cell density ratio and cell death rate in the freeze-thaw groups were significantly lower than those in the non-meniscal freeze-thaw groups at 3 and 6 weeks postoperatively. CONCLUSION: The freeze-thawed meniscus recovered few cells in its tissue even after 6 weeks. However, the defect was filled with fibrochondrocytes and proteoglycan when the synovium was intact. On the basis of these results, it is concluded that synovial cells are the primary contributors to meniscal injury repair. CLINICAL RELEVANCE: In meniscal tissue engineering, there is no consensus on the best cell source for meniscal repair. Based on this study, increasing the synovial activity and contribution should be the main objective of meniscal tissue engineering. This study can establish the foundation for future meniscal tissue engineering.

Rosai-Dorfman disease: earlier spontaneous regression of skin lesions relative to nasal, pharyngeal, and bone lesions.
Kazumasa Sato, Hideyuki Ujiie, Shinichi Nakazato, Mika Watanabe, Erika Watanabe, Teruki Yanagi, Yuji Nakamaru, Dai Takagi, Ryuta Arai, Tomohiro Onodera, Takeshi Kondo, Takanori Teshima, Hiroshi Shimizu
European journal of dermatology : EJD, 30, 2, 182, 183, 01 Apr. 2020, [International Magazine]
English, Scientific journal

軟部肉腫において喫煙歴は肺転移発生の危険因子である　　　　　　　　　　　　　　　
松岡 正剛, 相馬 有, 新井 隆太, 横田 勲, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 平賀 博明
日本整形外科学会雑誌, 94, 3, S576, S576, (公社)日本整形外科学会, Mar. 2020
Japanese

MicroRNA-9 ameliorates destructive arthritis through down-regulation of NF-κB1-RANKL pathway in fibroblast-like synoviocytes.
Wen Shi Lee, Shinsuke Yasuda, Michihiro Kono, Yuki Kudo, Sanae Shimamura, Michihito Kono, Yuichiro Fujieda, Masaru Kato, Kenji Oku, Tomohiro Shimizu, Tomohiro Onodera, Norimasa Iwasaki, Tatsuya Atsumi
Clinical immunology (Orlando, Fla.), 212, 108348, 108348, Mar. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, We investigated the effect of miR-9 on fibroblast-like synoviocytes (FLS) from RA patients and animal arthritis model. The binding of miR-9 to NF-κB1 3'UTR was analyzed by luciferase reporter assay and immunoprecipitation. ChIP assay and luciferase promoter assay were performed to identify the binding of NF-κB1 to RANKL promoter and its activity. FLS were treated with miR-9/anti-miR-9 to evaluate cell proliferation and the expression of RANKL. Therapeutic effect of intra-articular miR-9 was evaluated in type-II collagen-induced arthritis in rats. miR-9 bound to the 3'-UTR of NF-κB1 and downregulated NF-κB1. NF-κB1 bound to RANKL promoter and increased the promoter activity of RANKL. RANKL was downregulated by miR-9. Proliferation of FLS was increased by miR-9 inhibitor. miR-9 dampened experimental arthritis by lowering inflammatory state, reducing RANKL and osteoclasts formation. Our findings revealed miR-9-NF-κB1-RANKL pathway in RA-FLS, further, miR-9 ameliorated inflammatory arthritis in vivo which propose therapeutic implications of miR- 9 in RA.

好中球由来細胞外小胞が軟骨細胞に与える影響
江畑 拓, テルカウイ・アラー, 松前 元, 木田 博朗, 田 園, ヘンド・アルハサン, 高橋 大介, 小野寺 智洋, 岩崎 倫政
北海道整形災害外科学会雑誌, 62, 138th suppl, 5, 5, 北海道整形災害外科学会, 2020
Japanese

線状強皮症による足関節拘縮に対し全身療法と外科的加療の併用により改善が得られた1例
山口 哲也, 松岡 正剛, 小野寺 智洋, 松原 新史, 岩崎 倫政, 西江 渉, 清水 亜衣, 後藤 佳子, 近藤 英司, 岩崎 浩司
北海道整形災害外科学会雑誌, 62, 138th suppl, 41, 41, 北海道整形災害外科学会, 2020
Japanese

Blockade of XCL1/Lymphotactin Ameliorates Severity of Periprosthetic Osteolysis Triggered by Polyethylene-Particles.
Yuan Tian, Mohamad Alaa Terkawi, Tomohiro Onodera, Hend Alhasan, Gen Matsumae, Daisuke Takahashi, Masanari Hamasaki, Taku Ebata, Mahmoud Khamis Aly, Hiroaki Kida, Tomohiro Shimizu, Keita Uetsuki, Ken Kadoya, Norimasa Iwasaki
Frontiers in immunology, 11, 1720, 1720, 2020, [International Magazine]
English, Scientific journal, Periprosthetic osteolysis induced by orthopedic implant-wear particles continues to be the leading cause of arthroplasty failure in majority of patients. Release of the wear debris results in a chronic local inflammatory response typified by the recruitment of immune cells, including macrophages. The cellular mediators derived from activated macrophages favor the osteoclast-bone resorbing activity resulting in bone loss at the site of implant and loosening of the prosthetic components. Emerging evidence suggests that chemokines and their receptors are involved in the progression of periprosthetic osteolysis associated with aseptic implant loosening. In the current study, we investigated the potential role of chemokine C-motif-ligand-1 (XCL1) in the pathogenesis of inflammatory osteolysis induced by wear particles. Expressions of XCL1 and its receptor XCR1 were evident in synovial fluids and tissues surrounding hip-implants of patients undergoing revision total hip arthroplasty. Furthermore, murine calvarial osteolysis model induced by ultra-high molecular weight polyethylene (UHMWPE) particles was used to study the role of XCL1 in the development of inflammatory osteolysis. Mice received single injection of recombinant XCL1 onto the calvariae after implantation of particles exhibited significantly greater osteolytic lesions than the control mice. In contrast, blockade of XCL1 by neutralizing antibody significantly reduced bone erosion and the number of bone-resorbing mature osteoclasts induced by UHMWPE particles. In consistence with the results, transplantation of XCL1-soaked sponge onto calvariae caused osteolytic lesions coincident with excessive infiltration of inflammatory cells and osteoclasts. These results suggested that XCL1 might be involved in the development of periprosthetic osteolysis through promoting infiltration of inflammatory cells and bone resorbing-osteoclasts. Our further results demonstrated that supplementing recombinant XCL1 to cultured human monocytes stimulated with the receptor activator of nuclear factor kappa-B ligand (RANKL) promoted osteoclastogenesis and the osteoclast-bone resorbing activity. Moreover, recombinant XCL1 promoted the expression of inflammatory and osteoclastogenic factors, including IL-6, IL-8, and RANKL in human differentiated osteoblasts. Together, these results suggested the potential role of XCL1 in the pathogenesis of periprosthetic osteolysis and aseptic loosening. Our data broaden knowledge of the pathogenesis of aseptic prosthesis loosening and highlight a novel molecular target for therapeutic intervention.

Conservatively Treated Femoral Intertrochanteric Fracture With Early Asymptomatic Novel Coronavirus Disease 2019 (COVID-19): A Case Report.
Yuki Suzuki, Toshihiko Kasashima, Kazutoshi Hontani, Yasuhiro Yamamoto, Kanako Ito, Liang Xu, Masatake Matsuoka, Koji Iwasaki, Tomohiro Onodera, Eiji Kondo, Norimasa Iwasaki
Geriatric orthopaedic surgery & rehabilitation, 11, 2151459320969380, 2151459320969380, 2020, [International Magazine]
English, Introduction: The ongoing outbreak of novel coronavirus disease 2019 (COVID-19) is a worldwide problem. Although diagnosing COVID-19 in fracture patients is important for selecting treatment, diagnosing early asymptomatic COVID-19 is difficult. We describe herein a rare case of femoral intertrochanteric fracture concomitant with early asymptomatic novel COVID-19. Case presentation: An 87-year-old Japanese woman was transferred to our emergency room with a right hip pain after she fell. She had no fever, fatigue, or respiratory symptoms on admission and within the 14 days before presenting to our hospital, and no specific shadow was detected in chest X-ray. However, chest computed tomography (CT) was performed considering COVID-19 pandemic, and showed ground-glass opacities with consolidation in the dorsal segment of the right lower lung field. Then, qualitative real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) was carried out and turned out to be positive. She was diagnosed right femoral intertrochanteric fracture with concomitant COVID-19 infection. Conservative treatment was applied to the fracture due to infection. After admission, fever and oxygen demand occurred but she recovered from COVID-19. Throughout the treatment period, no cross-infection from the patient was identified in our hospital. Conclusion: This case highlights the importance of considering chest CT as an effective screening method for infection on hospital admission in COVID-19-affected areas, especially in trauma patients with early asymptomatic novel COVID-19.

Evaluation of Residual Human-Induced Pluripotent Stem Cells in Human Chondrocytes by Cell Type-Specific Glycosphingolipid Glycome Analysis Based on the Aminolysis-SALSA Technique.
Takuji Miyazaki, Hisatoshi Hanamatsu, Liang Xu, Tomohiro Onodera, Jun-Ichi Furukawa, Kentaro Homan, Rikiya Baba, Toshisuke Kawasaki, Norimasa Iwasaki
International journal of molecular sciences, 21, 1, 28 Dec. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Cartilage damage may eventually lead to osteoarthritis because it is difficult to repair. Human-induced pluripotent stem cell (iPSC)-derived chondrocytes may potentially be used to treat cartilage damage, but the tumorigenicity of iPSCs is a major concern for their application in regenerative medicine. Many glycoconjugates serve as stem cell markers, and glycosphingolipids (GSLs) including H type 1 antigen (Fucα1-2Galβ1-3GlcNAc) have been expressed on the surface of iPSCs. The purpose of the present study was to investigate whether GSL-glycome analysis is useful for quality control of residual iPSCs in chondrocytes. We performed GSL-glycome analysis of undifferentiated iPSCs in chondrocytes by combining glycoblotting and aminolysis-sialic acid linkage-specific alkylamidation (SALSA) method, enabling the detection of small quantities of iPSC-specific GSL-glycans from 5 × 104 cells. Furthermore, we estimated the residual amount of iPSCs using R-17F antibody, which possesses cytotoxic activity toward iPSCs that is dependent on the Lacto-N-fucopentaose I (LNFP I) of GSL. Moreover, we could detect a small number of LNFP I during mesenchymal stem cells (MSCs) differentiation from iPSCs. This is the first demonstration that GSL-glycome analysis is useful for detecting undifferentiated iPSCs, and can thereby support safe regenerative medicine.

Impact of Surgical Timing on Clinical Outcomes in Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction Using Hamstring Tendon Autografts.
Rikiya Baba, Eiji Kondo, Koji Iwasaki, Zenta Joutoku, Jun Onodera, Tomohiro Onodera, Tomonori Yagi, Norimasa Iwasaki, Kazunori Yasuda
Orthopaedic journal of sports medicine, 7, 11, 2325967119880553, 2325967119880553, Nov. 2019, [International Magazine]
English, Scientific journal, Background: To date, no studies have analyzed the influence on clinical outcomes of the interval between an anterior cruciate ligament (ACL) injury and double-bundle (DB) reconstruction with hamstring tendon autografts. Hypotheses: (1) Performing ACL reconstruction sooner after an injury will reduce postoperative anterior and rotatory knee instability, (2) postoperative range of knee motion or functional results will not be affected by different intervals between injury and surgery, and (3) preoperative isokinetic peak torque of the quadriceps and hamstring muscles will be lower in patients undergoing surgery earlier, while postoperative muscle strength will not be affected by surgery timing. Study Design: Cohort study; Level of evidence, 3. Methods: This study was conducted on a total of 171 patients who had undergone anatomic DB ACL reconstruction with hamstring tendon autografts. The patients were divided into 3 groups based on the time to surgery: (1) ≤1 month after the injury (group E; n = 25), (2) between 1 and 3 months after the injury (group M; n = 72), and (3) >3 months after the injury (group D; n = 74). Patients were assessed for a minimum of 2 years after surgery. Results: Concerning postoperative anterior laxity, 1-way analysis of variance demonstrated a significant difference (P = .0274) among the 3 groups. Anterior laxity was significantly less in group E than in group D (P = .0206). Spearman rank correlation analysis showed a significant correlation (ρ = 0.200; P = .0327) between anterior knee laxity and time to surgery. Also, a significant correlation (P = .0461) was found between the degree of the pivot-shift phenomenon and time to surgery. There were no significant differences in loss of knee extension or flexion among the 3 groups, nor were there any differences in the Lysholm knee score or International Knee Documentation Committee grade. Postoperatively, there were no significant differences in peak torque of the quadriceps or hamstring muscles among the 3 groups. Conclusion: Early DB reconstruction led to significantly less anterior laxity compared with delayed reconstruction. There were no significant differences in postoperative range of knee motion or functional results among the 3 time intervals between injury and surgery in this study.

【4疾患からみる膠原病のいま】小児線状強皮症に対してシクロスポリン内服が有効であった2例
眞井 翔子, 藤田 靖幸, 夏賀 健, 西江 渉, 小野寺 智洋, 岡 敏明, 清水 宏
皮膚科の臨床, 61, 12, 1797, 1802, 金原出版(株), Nov. 2019, [Peer-reviewed]
Japanese

Assessment of valgus laxity after release of the medial structure in medial open-wedge high tibial osteotomy: an in vivo biomechanical study using quantitative valgus stress radiography.
Dai Sato, Eiji Kondo, Koji Yabuuchi, Jun Onodera, Tomohiro Onodera, Tomonori Yagi, Keita Sakamoto, Akira Takasawa, Norimasa Iwasaki, Kazunori Yasuda
BMC musculoskeletal disorders, 20, 1, 481, 481, 27 Oct. 2019, [International Magazine]
English, Scientific journal, BACKGROUND: To perform medial open-wedge high tibial osteotomy (OWHTO), surgeons expose the medial-proximal tibia by releasing or cutting the superficial layer of the medial collateral ligament (sMCL). Biomechanically, the sMCL provides primary restraint against valgus forces. Therefore, any release of the sMCL can cause valgus instability of the knee joint. The purpose of this study was to assess valgus laxity after release of the medial structure of the knee during OWHTO. METHODS: Between 2009 and 2015, 84 consecutive patients (93 knees) who underwent OWHTO using a locking plate were enrolled in this study. All patients underwent radiological examinations before surgery, during surgery, 1 year after surgery, and after plate removal to objectively assess valgus laxity. The medial joint space (MJS) and the joint line convergence angle (JLCA) of the knee were evaluated using quantitative valgus stress radiography. Clinical evaluation was performed 2 years after surgery. RESULTS: The mean functional knee score improved significantly, from 65.5 to 91.1 points (p < 0.0001). The mechanical axis percentage shifted to pass through a point 69.7% lateral from the medial edge of the tibial plateau. The MJS and JLCA increased significantly during OWHTO surgery (11.0 mm, 7.4 °, p < 0.0001). However, no significant differences were noted in the MJS and JLCA among preoperative, 1-year postoperative periods and after plate removal. CONCLUSION: Valgus laxity was significantly greater after release of the sMCL. However, no significant differences were noted in valgus laxity in preoperative, 1-year postoperative periods and after plate removal. Complete release of the sMCL did not cause postoperative valgus laxity after OWHTO surgery. TRIAL REGISTRATION: Trial registration number: No.012-0360.

Depletion of glycosphingolipids induces excessive response of chondrocytes under mechanical stress.
Shinji Matsubara, Tomohiro Onodera, Eijiro Maeda, Daisuke Momma, Masatake Matsuoka, Kentaro Homan, Toshiro Ohashi, Norimasa Iwasaki
Journal of biomechanics, 94, 22, 30, 20 Sep. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Glycosphingolipids (GSLs) are ubiquitous membrane components that play an indispensable role in maintaining chondrocyte homeostasis. To gain better insight into roles of GSLs, we studied the effects of GSL-deletion on the physiological responses of chondrocytes to mechanical stress. Mice lacking Ugcg gene (Ugcg-/-) were genetically generated to obtain GSL-deficient mice, and their chondrocytes from the joints were used for functional analyses in vitro culture experiments. The cells were seeded in a three-dimensional collagen gel and subjected to 5%, 10% or 16% cyclic tensile strain for either 3 or 24 h. The gene expressions of chondrocyte anabolic and catabolic factors, and the induction of Ca2+ signaling were analyzed. Our results revealed that chondrocytes derived from GSL-deficient mice exhibited an elevation in the expression of catabolic factors (ADAMTS-5, MMP-13) following the exposure to strain with amplitudes of 10%. Likewise, applying cyclic tensile strain with these amplitudes resulted in an increased Ca2+ oscillation ratio in chondrocytes from GSL-deficient as compared to the ratio from control mice. These results demonstrated that deletion of GSL stimulated the catabolic responses of chondrocytes to mechanical stress via the augmentation of the sensitivity to mechanical stress that may lead to the cartilage deterioration. These findings suggest that the regulation of the physiological responses of chondrocytes by GSLs could be a potential target in a therapeutic intervention in osteoarthritis.

軟骨破片刺激モデルにおいて軟骨細胞は軟骨内骨化関連の遺伝子発現が上昇する
江畑 拓, 濱崎 雅成, Terkawi M. Alaa, 小野寺 智洋, 松前 元, 田 園, Alhasan Hend, 宮崎 拓自, 徐 亮, 菱村 亮介, 岩崎 倫政
日本整形外科学会雑誌, 93, 8, S1688, S1688, (公社)日本整形外科学会, Sep. 2019
Japanese

インプラントの破片によって引き起こされる炎症性骨溶解の発生におけるケモカインXCL1/リンホタクチンの関与　　　　　　　　　　　　　　　
田 園, テルカウイ・アラー, 小野寺 智洋, アルハサン・ヘンド, 松前 元, 高橋 大介, 濱崎 雅成, 江畑 拓, 岩崎 倫政
日本骨代謝学会学術集会プログラム抄録集, 37回, 183, 183, (一社)日本骨代謝学会, Sep. 2019
English

アテロコラーゲンを用いた自家培養軟骨移植の組織学的検討　　　　　　　　　　　　　　　
甲斐原 拓真, 近藤 英司, 岩崎 浩司, 小野寺 智洋, 遠山 晴一, 岩崎 倫政, 安田 和則
日本整形外科スポーツ医学会雑誌, 39, 4, 469, 469, (一社)日本整形外科スポーツ医学会, Aug. 2019
Japanese

Alteration of the Total Cellular Glycome during Late Differentiation of Chondrocytes.
Kentaro Homan, Hisatoshi Hanamatsu, Jun-Ichi Furukawa, Kazue Okada, Ikuko Yokota, Tomohiro Onodera, Norimasa Iwasaki
International journal of molecular sciences, 20, 14, 19 Jul. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, In normal articular cartilage, chondrocytes do not readily proliferate or terminally differentiate, and exhibit a low level of metabolism. Hypertrophy-like changes of chondrocytes have been proposed to play a role in the pathogenesis of osteoarthritis by inducing protease-mediated cartilage degradation and calcification; however, the molecular mechanisms underlying these changes are unclear. Glycans are located on the outermost cell surface. Dynamic cellular differentiation can be monitored and quantitatively characterized by profiling the glycan structures of total cellular glycoproteins. This study aimed to clarify the alterations in glycans upon late differentiation of chondrocytes, during which hypertrophy-like changes occur. Primary mouse chondrocytes were differentiated using an insulin-induced chondro-osteogenic differentiation model. Comprehensive glycomics, including N-glycans, O-glycans, free oligosaccharides, glycosaminoglycan, and glycosphingolipid, were analyzed for the chondrocytes after 0-, 10- and 20-days cultivation. The comparison and clustering of the alteration of glycans upon hypertrophy-like changes of primary chondrocytes were performed. Comprehensive glycomic analyses provided complementary alterations in the levels of various glycans derived from glycoconjugates during hypertrophic differentiation. In addition, expression of genes related to glycan biosynthesis and metabolic processes was significantly correlated with glycan alterations. Our results indicate that total cellular glycan alterations are closely associated with chondrocyte hypertrophy and help to describe the glycophenotype by chondrocytes and their hypertrophic differentiation. our results will assist the identification of diagnostic and differentiation biomarkers in the future.

Correction osteotomy for bilateral varus knee deformity caused by premature epiphyseal closure induced by hypervitaminosis A: a case report.
Masatake Matsuoka, Tomohiro Onodera, Tokifumi Majima, Koji Iwasaki, Daisuke Takahashi, Eiji Kondo, Norimasa Iwasaki
BMC musculoskeletal disorders, 20, 1, 287, 287, 15 Jun. 2019, [International Magazine]
English, Scientific journal, BACKGROUND: A vitamin A derivative, 13-cis-retinoic acid (isotretinoin), has been administered to treat several types of pediatric cancer and has improved survival rates in patients despite being known to induce premature epiphyseal closure. As the number of patients treated by 13-cis-retinoic acid increases, demands for salvage treatment after systemic retinoid therapy are emerging. However, few studies have described the surgical treatment of this disease. CASE PRESENTATION: We report a case with bilateral varus knee deformity due to premature epiphyseal closure that occurred during treatment with isotretinoin for neuroblastoma. The patient was successfully treated with correction osteotomy using a Taylor spatial frame in the right knee joint and femoral closed wedge osteotomy using a locking plate in left knee joint. Histopathological examination of the growth plate showed polar irregularity of chondrocytes and decreased cartilage matrix without apoptosis. In contrast, arthroscopic findings showed an intact joint surface. No recurrence of varus deformity was evident on follow-up at 1 year. CONCLUSIONS: To the best of our knowledge, this represents the first report of correction osteotomy for varus knee deformity due to premature epiphyseal closure that occurred during treatment with isotretinoin.

ACL遺残組織温存の賛否 解剖学的2束前十字靱帯再建術後の骨孔拡大における遺残組織温存の効果　　　　　　　　　　　　　　　
近藤 英司, 舛田 哲朗, 小野寺 純, 小野寺 智洋, 岩崎 浩司, 井上 雅之, 岩崎 倫政, 八木 知徳, 安田 和則
JOSKAS, 44, 4, 564, 564, (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019
Japanese

Chondrogenic differentiation of mouse induced pluripotent stem cells using the three-dimensional culture with ultra-purified alginate gel.
Kazutoshi Hontani, Tomohiro Onodera, Michiyo Terashima, Daisuke Momma, Masatake Matsuoka, Rikiya Baba, Zenta Joutoku, Shinji Matsubara, Kentaro Homan, Ryosuke Hishimura, Liang Xu, Norimasa Iwasaki
Journal of biomedical materials research. Part A, 107, 5, 1086, 1093, May 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, As articular cartilages have rarely healed by themselves because of their characteristics of avascularity and low cell density, surgical intervention is ideal for patients with cartilaginous injuries. Because of structural characteristics of the cartilage tissue, a three-dimensional culture of stem cells in biomaterials is a favorable system on cartilage tissue engineering. Induced pluripotent stem cells (iPSCs) are a new cell source in cartilage tissue engineering for its characteristics of self-renewal capability and pluripotency. However, the optimal cultivation condition for chondrogenesis of iPSCs is still unknown. Here we show that a novel chondrogenic differentiation method of iPSCs using the combination of three-dimensional cultivation in ultra-purified alginate gel (UPAL gel) and multi-step differentiation via mesenchymal stem cell-like cells (iPS-MSCs) could efficiently and specifically differentiate iPSCs into chondrocytes. The iPS-MSCs in UPAL gel culture sequentially enhanced the expression of chondrogenic marker without the upregulation of that of osteogenic and adipogenic marker and histologically showed homogeneous chondrogenic extracellular matrix formation. Our results suggest that the pluripotency of iPSCs can be controlled when iPSCs are differentiated into iPS-MSCs before embedding in UPAL gel. These results lead to the establishment of an efficient three-dimensional system to engineer artificial cartilage tissue from iPSCs for cartilage regeneration. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1086-1093, 2019.

遺残組織温存解剖学的二束前十字靱帯再建術の再鏡視所見 非温存群との年齢別検討
江畑 拓, 近藤 英司, 岩崎 浩司, 珍部 正嗣, 小野寺 智洋, 小野寺 純, 安田 和則, 八木 知徳, 岩崎 倫政
JOSKAS, 44, 2, 426, 427, (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2019
Japanese

CCL21/CCR7 axis regulating juvenile cartilage repair can enhance cartilage healing in adults.
Zenta Joutoku, Tomohiro Onodera, Masatake Matsuoka, Kentaro Homan, Daisuke Momma, Rikiya Baba, Kazutoshi Hontani, Masanari Hamasaki, Shinji Matsubara, Ryosuke Hishimura, Norimasa Iwasaki
Scientific reports, 9, 1, 5165, 5165, 26 Mar. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Juvenile tissue healing is capable of extensive scarless healing that is distinct from the scar-forming process of the adult healing response. Although many growth factors can be found in the juvenile healing process, the molecular mechanisms of juvenile tissue healing are poorly understood. Here we show that juvenile mice deficient in the chemokine receptor CCR7 exhibit diminished large-scale healing potential, whereas CCR7-depleted adult mice undergo normal scar-forming healing similar to wild type mice. In addition, the CCR7 ligand CCL21 was transiently expressed around damaged cartilage in juvenile mice, whereas it is rarely expressed in adults. Notably, exogenous CCL21 administration to adults decreased scar-forming healing and enhanced hyaline-cartilage repair in rabbit osteochondral defects. Our data indicate that the CCL21/CCR7 axis may play a role in the molecular control mechanism of juvenile cartilage repair, raising the possibility that agents modulating the production of CCL21 in vivo can improve the quality of cartilage repair in adults. Such a strategy may prevent post-traumatic arthritis by mimicking the self-repair in juvenile individuals.

Identification of IL-27 as potent regulator of inflammatory osteolysis associated with vitamin E-blended ultra-high molecular weight polyethylene debris of orthopedic implants
Terkawi MA, Kadoya K, Takahashi D, Tian Y, Hamasaki M, Matsumae G, Alhasan H, Elmorsy S, Uetsuki K, Onodera T, Takahata M, Iwasaki N
Acta Biomaterialia, 89, 242, 251, Mar. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Vitamin E-blended ultra-high molecular weight polyethylene (VE-UHMWPE) is a newly introduced material for prosthetic components that has proven a better mechanical performance with lesser adverse cellular responses than conventional polyethylene in experimental animal models. However, the mechanisms by which VE-UHMWPE particles trigger a reduced osteolytic activity are unclear and remain to be investigated. Therefore, the current study aims at exploring a possible anti-osteolytic mechanism associated with VE-UHMWPE particles. Transcriptional profiling and bioinformatic analyses of human macrophages stimulated by VE-UHMWPE particles revealed a distinct transcriptional program from macrophages stimulated with UHMWPE particles. Out of the up-regulated genes, IL-27 was found to be significantly elevated in macrophages cultured with VE-UHMWPE particles as compared to these with UHMWPE particles (p = 0.0084). Furthermore, we studied the potential anti-osteolytic function of IL-27 in osteolysis murine model. Interestingly, administration of recombinant IL-27 onto calvariae significantly alleviated osteolytic lesions triggered by UHMWPE particles (p = 0.0002). Likewise, IL-27 inhibited differentiation of osteoclasts (p = 0.0116) and reduced inflammatory response (p < 0.0001) elicited by conventional UHMWPE particles in vitro. This is the first study demonstrating the involvement of IL-27 in macrophage response to VE-UHMWPE particles and its regulatory role in osteolysis. Our data highlight a novel therapeutic agent for treatment of inflammatory osteolysis induced by polyethylene debris. STATEMENT OF SIGNIFICANCE: Aseptic loosening due to inflammatory osteolysis remains the major cause of arthroplasty failure and represents a substantial economic burden worldwide. Ideal approach to prevent this failure should be directed to minimize inflammatory response triggered by wear particles at the site of implant. Understanding the mechanism by which VE-UHMWPE particles triggers lesser cellular responses and reduced osteolysis as compared to conventional UHMWPE particles may aid in discovery of regulatory factors. In the current study, we reported that IL-27 is a potent regulator of inflammatory osteolysis involved in the reduced biologic activities and osteolytic potentials associated with VE-UHMWPE particles. Initiating the production IL-27 in vivo after total joint arthroplasties might be a novel strategy to prolong the life-spam of implant.

Effects of Ultra-Purified Alginate Gel Implantation on Meniscal Defects in Rabbits.
WooYoung Kim, Tomohiro Onodera, Eiji Kondo, Yasuyuki Kawaguchi, Mohamad Alaa Terkawi, Rikiya Baba, Kazutoshi Hontani, Zenta Joutoku, Shinji Matsubara, Kentaro Homan, Ryosuke Hishimura, Norimasa Iwasaki
The American journal of sports medicine, 47, 3, 640, 650, Mar. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Many tissue-engineered methods for meniscal repair have been studied, but their utility remains unclear. HYPOTHESIS: Implantation of low-endotoxin, ultra-purified alginate (UPAL) gel without cells could induce fibrocartilage regeneration on meniscal defects in rabbits. STUDY DESIGN: Controlled laboratory study. METHODS: Forty-two mature Japanese White rabbits were divided into 2 groups of 21 animals each. In each animal, a cylindrical defect measuring 2 mm in diameter was created with a biopsy punch on the anterior horn of the medial meniscus. In the control group, no treatment was applied on the left medial meniscal defect. In the UPAL gel group, the right medial meniscal defect was injected with the UPAL gel and gelated by a CaCl2 solution. Samples were evaluated at 3, 6, and 12 weeks postoperatively. For biomechanical evaluation, 6 additional samples from intact animals were used for comparison. RESULTS: The macroscopic score was significantly greater in the UPAL gel group than in the control group at 3 weeks (mean ± SE: 5.6 ± 0.82 vs 3.4 ± 0.83, P = .010), 6 weeks (5.9 ± 0.72 vs 2.5 ± 0.75, P = .026), and 12 weeks (5.2 ± 1.21 vs 1.0 ± 0.63, P = .020). The histological score was significantly greater in the UPAL group than in the control group at 3 weeks (2.1 ± 0.31 vs 1.2 ± 0.25, P = .029) and 12 weeks (2.2 ± 0.55 vs 0.3 ± 0.21, P = .016). The mean stiffness of the reparative tissue in the UPAL gel group was significantly greater than that in the control group at 6 weeks (24.325 ± 3.920 N/mm vs 8.723 ± 1.190 N/mm, P = .006) and at 12 weeks (27.804 ± 6.169 N/mm vs not applicable [because of rupture]). CONCLUSION: The UPAL gel enhanced the spontaneous repair of fibrocartilage tissues in a cylindrical meniscal defect in rabbits. CLINICAL RELEVANCE: These results imply that the acellular UPAL gel may improve the repair of traumatic meniscal injuries.

Preoperative radiographic and clinical factors associated with postoperative floating of the lesser toes after resection arthroplasty for rheumatoid forefoot deformity.
Tomohiro Onodera, Hiroaki Nakano, Kentaro Homan, Eiji Kondo, Norimasa Iwasaki
BMC musculoskeletal disorders, 20, 1, 87, 87, 19 Feb. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: This study aimed to clarify the characteristics associated with postoperative floating of the lesser toes, especially focusing on the medial and lateral lessor toes, after arthrodesis of the first metatarsophalangeal joint and resection arthroplasty of the lessor toes in rheumatoid forefoot deformity. METHODS: Fourty-seven feet of 43 people who underwent resection arthroplasty of the metatarsal head of the lesser toes for rheumatoid arthritis of the metatarsophalangeal joints were included. We retrospectively evaluated the preoperative radiographic findings and clinical characteristics of the patients, and the occurrence of postoperative floating of the lesser toes. The mean duration of follow-up was 36.5 (range 12 to 114) months. RESULTS: Preoperative dislocation grades of the second and third toes that demonstrated postoperative floating were significantly higher than those of toes that did not experience postoperative floating. The hallux valgus deformity before surgery was significantly more severe in toes with postoperative floating of the second and third lessor toes than those with no floating (p < 0.05). In addition, the Japanese Society for Surgery of the Foot (JSSF) hallux scale scores before surgery in toes with postoperative floating of the fourth and fifth lessor toes were significantly worse than those in non-dislocating toes (p < 0.05). CONCLUSIONS: The preoperative condition of the first metatarsophalangeal joint, including hallux valgus deformity, pain, range of motion, activity of daily living, and function is significantly different between postoperative floating of the lesser toes and non-floating of them after resection arthroplasty for rheumatoid forefoot deformity.

軟骨破片刺激モデルにおいて軟骨細胞は軟骨内骨化関連の遺伝子発現が上昇する
江畑 拓, 濱崎 雅成, アラー・テルカウイ, 小野寺 智洋, 松前 元, 田 園, ヘンド・アルハサン, 宮崎 拓自, 徐 亮, 細川 吉暁, 岩崎 倫政
北海道整形災害外科学会雑誌, 61, 137th suppl, 35, 35, 北海道整形災害外科学会, 2019
Japanese

骨軟骨欠損に対する骨髄穿刺濃縮細胞と高純度アルギン酸ゲル併用移植の検討
徐 亮, 瓜田 淳, 小野寺 智洋, 菱村 亮介, 濱崎 雅成, 梁 大偉, 宝満 健太郎, 岩崎 倫政
北海道整形災害外科学会雑誌, 61, 137th suppl, 13, 13, 北海道整形災害外科学会, 2019
Japanese

軟骨再生医療への応用を標的とした未分化iPS細胞特異的除去法の検討
宮崎 拓自, 小野寺 智洋, 徐 亮, 宝満 健太郎, 濱崎 雅成, 岩崎 倫政, 花松 久寿, 古川 潤一, 川嵜 敏祐
北海道整形災害外科学会雑誌, 61, 137th suppl, 34, 34, 北海道整形災害外科学会, 2019
Japanese

両先天性内反母趾に対し両第I中足骨外反矯正骨切り術を施行した1例
徳廣 泰貴, 小野寺 智洋, 上徳 善太, 岩崎 浩司, 新井 隆太, 岩崎 倫政, 近藤 英司
北海道整形災害外科学会雑誌, 61, 136th suppl, 36, 36, 北海道整形災害外科学会, 2019
Japanese

膝十字靱帯不全を合併した内側型変形性膝関節症に対する膝十字靱帯再建術と高位脛骨骨切り術の二期的手術の短期成績
清水 寛和, 岩崎 浩司, 近藤 英司, 小野寺 智洋, 新井 隆太, 上徳 善太, 岩崎 倫政
北海道整形災害外科学会雑誌, 61, 137th suppl, 23, 23, 北海道整形災害外科学会, 2019
Japanese

A Novel Cartilage Fragments Stimulation Model Revealed that Macrophage Inflammatory Response Causes an Upregulation of Catabolic Factors of Chondrocytes In Vitro.
Hamasaki M, Terkawi MA, Onodera T, Homan K, Iwasaki N
Cartilage, 12, 1947603519828426, 354, 361, Jan. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: Osteoarthritis is a progressive joint disease characterized by cartilage degradation and synovial inflammation. Presence of cartilage fragments in the joint due to degradation of cartilage is thought to be associated with local inflammatory response and progressive osteoarthritic process. Understanding the mechanism by which cartilage fragments elicit this destructive process should aid in designing novel therapeutic approaches. Therefore, objective of current study is to establish an in vitro model to examine the cross-talk between chondrocytes and cartilage fragments-stimulated macrophages. DESIGN: Cartilage fragments were prepared from femoral head cartilages of mice and analyzed using a scanning electron microscope and particle size analyzer. Bone marrow-derived macrophages were co-cultured with cartilage fragments and chondrocytes using transwell co-culture system. Macrophage inflammatory mediators in supernatant of cultures were determined by ELISA and gene expression of macrophages and chondrocyte were quantified by qRT-PCR. RESULTS: Shapes of cartilage fragments were irregular with sizes ranged between 0.54 and 55 μm. Macrophages cultured with cartilage fragments released significantly higher concentrations of TNF-α, IL-6, and NO than those of mock and control. Consistently, gene expressions of TNF-α, IL-6, and MMP-9 were significantly increased in stimulated macrophages. The elevation in production of pro-inflammatory molecules in stimulated macrophages cultures were coincident with an increase in gene expression of chondrocyte MMP-13, iNOS, and IL-6. CONCLUSION: We developed an in vitro co-culture model to study the impact of stimulation of macrophage by cartilage fragments on the expression of chondrocyte carbolic factors. Our results revealed that cartilage fragments triggered macrophages inflammatory response that enhanced the production of chondrocyte catabolic factors.

Osteochondral Autograft Transplantation Technique Augmented by an Ultrapurified Alginate Gel Enhances Osteochondral Repair in a Rabbit Model
Ryosuke Hishimura, Tomohiro Onodera, Kazutoshi Hontani, Rikiya Baba, Kentaro Homan, Shinji Matsubara, Zenta Joutoku, WooYoung Kim, Takayuki Nonoyama, Takayuki Kurokawa, Jian Ping Gong, Norimasa Iwasaki
American Journal of Sports Medicine, 47, 2, 468, 478, SAGE Publications, Jan. 2019, [Peer-reviewed]
English, Scientific journal

Coordinated existence of multiple gangliosides is required for cartilage metabolism.
Momma D, Onodera T, Homan K, Matsubara S, Sasazawa F, Furukawa J, Matsuoka M, Yamashita T, Iwasaki N
Osteoarthritis Cartilage, Nov. 2018, [Peer-reviewed]
English, Scientific journal

マウスiPS細胞からの軟骨分化誘導と糖鎖解析を用いた新規バイオマーカーの探索
本谷 和俊, 小野寺 智洋, 寺島 理代, 門間 太輔, 松岡 正剛, 馬場 力哉, 上徳 善太, 松原 新史, 宝満 健太郎, 菱村 亮介, 金 佑泳, 濱崎 雅成, 徐 亮, 岩崎 倫政
北海道整形災害外科学会雑誌, 60, 1, 145, 145, 北海道整形災害外科学会, Aug. 2018
Japanese

軟骨細胞の力学的ストレス応答におけるスフィンゴ糖脂質の機能解析
松原 新史, 小野寺 智洋, 門間 太輔, 馬場 力哉, 本谷 和俊, 上徳 善太, 宝満 健太郎, 岩崎 倫政, 大橋 俊朗, 前田 英次郎
北海道整形災害外科学会雑誌, 60, 1, 145, 146, 北海道整形災害外科学会, Aug. 2018
Japanese

自家骨軟骨柱移植術に高純度アルギン酸ゲルを併用した治療効果の検討
菱村 亮介, 小野寺 智洋, 上徳 善太, 宝満 健太郎, 松原 新史, 金 佑泳, 濱崎 雅成, 岩崎 倫政
日本整形外科学会雑誌, 92, 8, S1639, S1639, (公社)日本整形外科学会, Aug. 2018
Japanese

軟骨変性と肥大分化における軟骨細胞グライコームの類似性
宝満 健太郎, 小野寺 智洋, 花松 久寿, 古川 潤一, 上徳 善太, 松原 新史, 菱村 亮介, 金 佑泳, 濱崎 雅成, 宮崎 拓自, 岩崎 倫政
日本整形外科学会雑誌, 92, 8, S1653, S1653, (公社)日本整形外科学会, Aug. 2018
Japanese

マクロファージ共培養モデルにおいて軟骨破片が引き起こすマクロファージの炎症反応および軟骨細胞への影響
濱崎 雅成, Terkawi Mohamad Alaa, 小野寺 智洋, 宝満 健太郎, 上徳 善太, 松原 新史, 菱村 亮介, 徐 亮, 宮崎 拓自, 田 園, 岩崎 倫政
日本整形外科学会雑誌, 92, 8, S2012, S2012, (公社)日本整形外科学会, Aug. 2018
Japanese

膝複合靱帯損傷を合併した脛骨高原骨折術後下肢外反変形に対してDouble Level Osteotomyを行った1例　　　　　　　　　　　　　　　
下田 康平, 近藤 英司, 珍部 正嗣, 小野寺 智洋, 新井 隆太, 岩崎 浩司, 岩崎 倫政
北海道整形災害外科学会雑誌, 60, 1, 109, 115, 北海道整形災害外科学会, Aug. 2018
Japanese

Bone Marrow Stimulation Technique Augmented by an Ultrapurified Alginate Gel Enhances Cartilage Repair in a Canine Model.
Rikiya Baba, Tomohiro Onodera, Masatake Matsuoka, Kazutoshi Hontani, Zenta Joutoku, Shinji Matsubara, Kentaro Homan, Norimasa Iwasaki
The American journal of sports medicine, 46, 8, 1970, 1979, Jul. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: The optimal treatment for a medium- or large-sized cartilage lesion is still controversial. Since an ultrapurified alginate (UPAL) gel enhances cartilage repair in animal models, this material is expected to improve the efficacy of the current treatment strategies for cartilage lesions. HYPOTHESIS: The bone marrow stimulation technique (BMST) augmented by UPAL gel can induce hyaline-like cartilage repair. STUDY DESIGN: Controlled laboratory study. METHODS: Two cylindrical osteochondral defects were created in the patellar groove of 27 beagle dogs. A total of 108 defects were divided into 3 groups: defects without intervention (control group), defects with the BMST (microfracture group), and defects with the BMST augmented by implantation of UPAL gel (combined group). At 27 weeks postoperatively, macroscopic and histological evaluations, micro-computed tomography assessment, and mechanical testing were performed for each reparative tissue. RESULTS: The defects in the combined group were almost fully covered with translucent reparative tissues, which consisted of hyaline-like cartilage with well-organized collagen structures. The macroscopic score was significantly better in the combined group than in the control group ( P < .05). The histological scores in the combined group were significantly better than those in the control group ( P < .01) and microfracture group ( P < .05). Although the repaired subchondral bone volumes were not influenced by UPAL gel augmentation, the mechanical properties of the combined group were significantly better than those of the microfracture group ( P < .05). CONCLUSION: The BMST augmented by UPAL gel elicited hyaline-like cartilage repair that had characteristics of rich glycosaminoglycan and matrix immunostained by type II collagen antibody in a canine osteochondral defect model. The present results suggest that the current technique has the potential to be one of the autologous matrix-induced chondrogenesis techniques of the future and to expand the operative indications for the BMST without loss of its technical simplicity. CLINICAL RELEVANCE: The data support the clinical reality of 1-step minimally invasive cartilage-reparative medicine with UPAL gel without harvesting donor cells.

Double-Bundle Anterior Cruciate Ligament Reconstruction Using Hamstring Tendon Hybrid Grafts in Patients Over 40 Years of Age: Comparisons Between Different Age Groups
Yusuke Nishio, Eiji Kondo, Jun Onodera, Tomohiro Onodera, Tomonori Yagi, Norimasa Iwasaki, Kazunori Yasuda
Orthopaedic Journal of Sports Medicine, 6, 5, 2325967118773685, SAGE Publications Ltd, 21 May 2018, [Peer-reviewed]
English, Scientific journal

膝屈筋腱ハイブリッド代用材料を用いた遺残組織温存解剖学的2束前十字靱帯再建術の再鏡視所見 非温存群との年齢別の検討　　　　　　　　　　　　　　　
江畑 拓, 近藤 英司, 岩崎 浩司, 珍部 正嗣, 新井 隆太, 小野寺 智洋, 小野寺 純, 安田 和則, 八木 知徳, 岩崎 倫政
JOSKAS, 43, 4, 685, 685, (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2018
Japanese

膝屈筋腱ハイブリッド代用材料を用いた遺残組織温存解剖学的2束前十字靱帯再建術の臨床成績 非温存群との年齢別検討
江畑 拓, 近藤 英司, 岩崎 浩司, 珍部 正嗣, 新井 隆太, 小野寺 智洋, 小野寺 純, 安田 和則, 八木 知徳, 岩崎 倫政
日本整形外科学会雑誌, 92, 3, S617, S617, (公社)日本整形外科学会, Mar. 2018
Japanese

軟骨細胞肥大分化の包括的N型糖鎖プロファイリングによる糖鎖バイオマーカー探索
宝満 健太郎, 小野寺 智洋, 花松 久寿, 古川 潤一, 門間 太輔, 松岡 正剛, 馬場 力哉, 本谷 和俊, 上徳 善太, 松原 新史, 菱村 亮介, 金 佑詠, 濱崎 雅成, 岩崎 倫政
北海道整形災害外科学会雑誌, 60, 134th suppl, 36, 36, 北海道整形災害外科学会, 2018
Japanese

マクロファージ共培養モデルにおいて軟骨破片が軟骨細胞に与える影響
濱崎 雅成, テルカウイ・アラー, 小野寺 智洋, 宝満 健太郎, 上徳 善太, 松原 新史, 菱村 亮介, 徐 亮, 田 園, 岩崎 倫政
北海道整形災害外科学会雑誌, 60, 134th suppl, 37, 37, 北海道整形災害外科学会, 2018
Japanese

自家骨軟骨柱移植術に高純度アルギン酸ゲルを併用した治療効果の検証
菱村 亮介, 小野寺 智洋, 上徳 善太, 宝満 健太郎, 松原 新史, 金 佑泳, 濱崎 雅成, 岩崎 倫政
北海道整形災害外科学会雑誌, 60, 135th suppl, 22, 22, 北海道整形災害外科学会, 2018
Japanese

膝屈筋腱ハイブリッド代用材料を用いた遺残組織温存解剖学的2束前十字靱帯再建術の臨床成績 非温存群との年齢別検討
江畑 拓, 近藤 英司, 岩崎 浩司, 新井 隆太, 小野寺 智洋, 小野寺 純, 安田 和則, 八木 知徳, 岩崎 倫政
北海道整形災害外科学会雑誌, 60, 135th suppl, 24, 24, 北海道整形災害外科学会, 2018
Japanese

ビタミンA誘導体の長期投与による早期骨端線閉鎖により両膝内反変形を認めた一例
長谷川 裕一, 小野寺 智洋, 岩崎 浩司, 珍部 正嗣, 新井 隆太, 近藤 英司, 岩崎 倫政
北海道整形災害外科学会雑誌, 60, 135th suppl, 63, 63, 北海道整形災害外科学会, 2018
Japanese

両膝に発生した内側円板状半月板の1例
青木 佑介, 珍部 正嗣, 近藤 英司, 岩崎 浩司, 新井 隆太, 小野寺 智洋, 安田 和則, 岩崎 倫政
北海道整形災害外科学会雑誌, 60, 135th suppl, 63, 63, 北海道整形災害外科学会, 2018
Japanese

自家骨軟骨柱移植術に高純度アルギン酸ゲルを併用した治療効果の検証　　　　　　　　　　　　　　　
菱村 亮介, 小野寺 智洋, 上徳 善太, 宝満 健太郎, 松原 新史, 金 佑泳, 濱崎 雅成, 岩崎 倫政
北海道整形災害外科学会雑誌, 60, 135th suppl, 22, 22, 北海道整形災害外科学会, 2018
Japanese

Transcriptional profile of human macrophages stimulated by ultra-high molecular weight polyethylene particulate debris of orthopedic implants uncovers a common gene expression signature of rheumatoid arthritis
Mohamad Alaa Terkawi, Masanari Hamasaki, Daisuke Takahashi, Masahiro Ota, Ken Kadoya, Tomoyo Yutani, Keita Uetsuki, Tsuyoshi Asano, Tohru Irie, Ryuta Arai, Tomohiro Onodera, Masahiko Takahata, Norimasa Iwasaki
Acta Biomaterialia, 65, 417, 425, Acta Materialia Inc, 01 Jan. 2018, [Peer-reviewed]
English, Scientific journal

Quantitative knee cartilage measurement at MR imaging of patients with anterior cruciate ligament tear
Kazuki Kato, Tamotsu Kamishima, Eiji Kondo, Tomohiro Onodera, Shota Ichikawa
Radiological Physics and Technology, 10, 4, 431, 438, Springer Tokyo, 01 Dec. 2017, [Peer-reviewed]
English, Scientific journal

Preoperative knee deformity and kinematics impact postoperative knee kinematics in total knee arthroplasty
Naoki Seito, Tomohiro Onodera, Yasuhiko Kasahara, Eiji Kondo, Norimasa Iwasaki, Tokifumi Majima
The Knee, 24, 6, 1462, 1468, Elsevier BV, Dec. 2017, [Peer-reviewed]
Scientific journal

Depletion of Gangliosides Enhances Articular Cartilage Repair in Mice
Masatake Matsuoka, Tomohiro Onodera, Kentaro Homan, Fumio Sasazawa, Jun-ichi Furukawa, Daisuke Momma, Rikiya Baba, Kazutoshi Hontani, Zenta Joutoku, Shinji Matsubara, Tadashi Yamashita, Norimasa Iwasaki
SCIENTIFIC REPORTS, 7, 43729, Mar. 2017, [Peer-reviewed]
English, Scientific journal

A rare case of multiple phosphaturic mesenchymal tumors along a tendon sheath inducing osteomalacia
Ryuta Arai, Tomohiro Onodera, Mohamad Alaa Terkawi, Tomoko Mitsuhashi, Eiji Kondo, Norimasa Iwasaki
BMC MUSCULOSKELETAL DISORDERS, 18, 1, 79, Feb. 2017, [Peer-reviewed]
English, Scientific journal

Comparison of femoral head translation following eccentric rotational acetabular osteotomy and rotational acetabular osteotomy
Tohru Irie, Daisuke Takahashi, Tsuyoshi Asano, Ryuta Arai, Takuya Konno, Tomohiro Onodera, Eiji Kondo, Norimasa Iwasaki
HIP INTERNATIONAL, 27, 1, 49, 54, Jan. 2017, [Peer-reviewed]
English, Scientific journal

Efficacy of teriparatide in the treatment of nontraumatic osteonecrosis of the femoral head: a retrospective comparative study with alendronate
Ryuta Arai, Daisuke Takahashi, Masahiro Inoue, Tohru Irie, Tsuyoshi Asano, Takuya Konno, Mohamad Alaa Terkawi, Tomohiro Onodera, Eiji Kondo, Norimasa Iwasaki
BMC MUSCULOSKELETAL DISORDERS, 18, 1, 24, Jan. 2017, [Peer-reviewed]
English, Scientific journal

マテリアルと細胞 ultra-purified alginate gel(UPAL gel)を用いたマウスiPS細胞からの軟骨分化誘導　　　　　　　　　　　　　　　
本谷 和俊, 小野寺 智洋, 寺島 理代, 門間 太輔, 松岡 正剛, 馬場 力哉, 上徳 善太, 松原 新史, 宝満 健太郎, 菱村 亮介, 金 佑泳, 徐 亮, 岩崎 倫政
日本バイオマテリアル学会大会予稿集, シンポジウム2016, 92, 92, 日本バイオマテリアル学会, Nov. 2016
Japanese

Use of a pneumatic tourniquet in total knee arthroplasty increases the risk of distal deep vein thrombosis: A prospective, randomized study
Noriaki Mori, Shoichi Kimura, Tomohiro Onodera, Norimasa Iwasaki, Izumi Nakagawa, Takeshi Masuda
KNEE, 23, 5, 887, 889, Oct. 2016, [Peer-reviewed]
English, Scientific journal

A Novel Bone Marrow Stimulation Technique Augmented by Administration of Ultrapurified Alginate Gel Enhances Osteochondral Repair in a Rabbit Model
Rikiya Baba, Tomohiro Onodera, Daisuke Momma, Masatake Matsuoka, Kazutoshi Hontani, Sameh Elmorsy, Kaori Endo, Masahiro Todoh, Shigeru Tadano, Norimasa Iwasaki
TISSUE ENGINEERING PART C-METHODS, 21, 12, 1263, 1273, Dec. 2015, [Peer-reviewed]
English, Scientific journal

External rotation of the femoral component decreases patellofemoral contact stress in total knee arthroplasty
Takashi Terashima, Tomohiro Onodera, Naohiro Sawaguchi, Yasuhiko Kasahara, Tokifumi Majima
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 23, 11, 3266, 3272, Nov. 2015, [Peer-reviewed]
English, Scientific journal

Therapeutic effects of intra-articular ultra-purified low endotoxin alginate administration on an experimental canine osteoarthritis model
Yukinori Tsukuda, Tomohiro Onodera, Masayuki Ito, Yasuharu Izumisawa, Yasuhiko Kasahara, Tatsuya Igarashi, Nobuo Ohzawa, Masahiro Todoh, Shigeru Tadano, Norimasa Iwasaki
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 103, 11, 3441, 3448, Nov. 2015, [Peer-reviewed]
English, Scientific journal

変形性足関節症、リウマチ性足関節炎、距骨骨壊死におけるIlizarov創外固定器を用いた足関節固定術の臨床成績の検討
深谷 英昭, 小野寺 智洋, 中野 宏昭, 新井 隆太, 高橋 大介, 岩崎 倫政
日本足の外科学会雑誌, 36, 1, 157, 161, 日本足の外科学会, 01 Sep. 2015
Japanese

足趾腫瘍による腫瘍性骨軟化症の一例
新井 隆太, 小野寺 智洋, 松原 新史, 山本 励志, 岩崎 倫政
日本足の外科学会雑誌, 36, 1, 340, 344, 日本足の外科学会, 01 Sep. 2015
Japanese

Syndecan 4 Regulation of the Development of Autoimmune Arthritis in Mice by Modulating B Cell Migration and Germinal Center Formation.
Tsutomu Endo, Koyu Ito, Junko Morimoto, Masashi Kanayama, Daichi Ota, Masahiro Ikesue, Shigeyuki Kon, Daisuke Takahashi, Tomohiro Onodera, Norimasa Iwasaki, Toshimitsu Uede
Arthritis & rheumatology (Hoboken, N.J.), 67, 9, 2512, 22, Sep. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: Syndecan 4 has been implicated as a critical mediator of inflammatory responses because of its functions as a coreceptor and reservoir for growth factors and chemokines. Although syndecan 4 is known to be expressed on B cells, its role in immune responses remains unclear. The purpose of this study was to investigate the contribution of syndecan 4 to the development of immune arthritis in murine models. METHODS: The clinical severity of 3 immunopathologically distinct models, collagen-induced arthritis (CIA), antigen-induced arthritis (AIA), and collagen antibody-induced arthritis (CAIA), was evaluated in wild-type (WT) mice and in syndecan 4-deficient (Sdc4(-/-) ) mice. Germinal center (GC) formation, B cell profiles, humoral immune responses, and B cell migration were analyzed during the course of CIA. RESULTS: Sdc4(-/-) mice were resistant to the induction of CIA, which is T cell and B cell dependent, but AIA and CAIA, which are T cell dependent and T cell independent, respectively, occurred with equal frequency in WT mice and Sdc4(-/-) mice. Furthermore, Sdc4(-/-) mice had reduced numbers of B cells and deficient GC formation in draining lymph nodes (DLNs) during the course of CIA, resulting in reduced production of collagen-specific autoantibodies. Compared with B cells from WT mice, B cells from Sdc4(-/-) mice showed reduced chemotactic migration toward stromal cell-derived factor 1 (SDF-1) and reduced SDF-1-mediated Akt phosphorylation. Consistent with these findings, in vivo transfer experiments showed that fewer Sdc4(-/-) B cells than WT B cells were found in and around the follicles in the DLNs. CONCLUSION: Our findings suggest that syndecan 4 contributes to the development of CIA by promoting GC formation and autoantibody production through its regulation of SDF-1-mediated B cell migration.

An Articular Cartilage Repair Model in Common C57Bl/6 Mice
Masatake Matsuoka, Tomohiro Onodera, Fumio Sasazawa, Daisuke Momma, Rikiya Baba, Kazutoshi Hontani, Norimasa Iwasaki
TISSUE ENGINEERING PART C-METHODS, 21, 8, 767, 772, Aug. 2015, [Peer-reviewed]
English, Scientific journal

A Comparative Study With In Vitro Ultrasonographic and Histologic Grading of Metatarsal Head Cartilage in Rheumatoid Arthritis
Tomohiro Onodera, Yasuhiko Kasahara, Toshiyuki Kasemura, Yuki Suzuki, Eiji Kondo, Norimasa Iwasaki
FOOT & ANKLE INTERNATIONAL, 36, 7, 774, 779, Jul. 2015, [Peer-reviewed]
English, Scientific journal

Correlation Between Knee Kinematics and Patellofemoral Contact Pressure in Total Knee Arthroplasty
Takuya Konno, Tomohiro Onodera, Yusuke Nishio, Yasuhiko Kasahara, Norimasa Iwasaki, Tokifumi Majima
JOURNAL OF ARTHROPLASTY, 29, 12, 2305, 2308, Dec. 2014, [Peer-reviewed]
English, Scientific journal

Quantitative glycomics monitoring of induced pluripotent- and embryonic stem cells during neuronal differentiation
Michiyo Terashima, Maho Amano, Tomohiro Onodera, Shin-Ichiro Nishimura, Norimasa Iwasaki
STEM CELL RESEARCH, 13, 3, 454, 464, Nov. 2014, [Peer-reviewed]
English, Scientific journal

Intraoperative Medial Pivot Affects Deep Knee Flexion Angle and Patient-Reported Outcomes After Total Knee Arthroplasty
Yusuke Nishio, Tomohiro Onodera, Yasuhiko Kasahara, Daisuke Takahashi, Norimasa Iwasaki, Tokifumi Majima
JOURNAL OF ARTHROPLASTY, 29, 4, 702, 706, Apr. 2014, [Peer-reviewed]
English, Scientific journal

股関節後方脱臼骨折の治療成績
清水 智弘, 高橋 大介, 笠原 靖彦, 小野寺 智洋, 西尾 悠介, 紺野 拓也, 岩崎 倫政, 眞島 任史, 井上 正弘, 田辺 明彦, 入江 徹
北海道整形災害外科学会雑誌, 55, 2, 346, 346, 北海道整形災害外科学会, Mar. 2014
Japanese

Depletion of gangliosides enhances cartilage degradation in mice
F. Sasazawa, T. Onodera, T. Yamashita, N. Seito, Y. Tsukuda, N. Fujitani, Y. Shinohara, N. Iwasaki
OSTEOARTHRITIS AND CARTILAGE, 22, 2, 313, 322, Feb. 2014, [Peer-reviewed]
English, Scientific journal

Celecoxib does not affect the release of hyaluronic acid in end stage osteoarthritic joints
Daisuke Takahashi, Tokifumi Majima, Tomohiro Onodera, Yasuhiko Kasahara, Masahiro Inoue, Toru Irie, Toshiyuki Kasemura
MODERN RHEUMATOLOGY, 23, 5, 934, 938, Sep. 2013, [Peer-reviewed]
English, Scientific journal

Posterior Femoral Condylar Offset After Total Knee Replacement in The Risk of Knee Flexion Contracture
Tomohiro Onodera, Tokifumi Majima, Osamu Nishiike, Yasuhiko Kasahara, Daisuke Takahashi
JOURNAL OF ARTHROPLASTY, 28, 7, 1112, 1116, Aug. 2013, [Peer-reviewed]
English, Scientific journal

Sagittal Alignment of the First Metatarsophalangeal Joint after Arthrodesis for Rheumatoid Forefoot Deformity
Akihiko Tanabe, Tokifumi Majima, Tomohiro Onodera, Naohiro Sawaguchi, Takuya Watanabe, Yasuhiko Kasahara, Daisuke Takahashi
JOURNAL OF FOOT & ANKLE SURGERY, 52, 3, 343, 347, May 2013, [Peer-reviewed]
English, Scientific journal

Hemorrhagic-acquired factor XIII deficiency associated with tocilizumab for treatment of rheumatoid arthritis
Masatake Matsuoka, Tokifumi Majima, Tomohiro Onodera, Masahiro Ieko, Masayoshi Souri, Akitada Ichinose, Takashi Kurita, Yasuhiko Kasahara, Masahiro Inoue, Daisuke Takahashi
INTERNATIONAL JOURNAL OF HEMATOLOGY, 96, 6, 781, 785, Dec. 2012, [Peer-reviewed]
English, Scientific journal

Outcome of Transfibular Ankle Arthrodesis with Ilizarov Apparatus
Tomohiro Onodera, Tokifumi Majima, Yasuhiko Kasahara, Daisuke Takahashi, Shuji Yamazaki, Ryo Ando, Akio Minami
FOOT & ANKLE INTERNATIONAL, 33, 11, 964, 968, Nov. 2012, [Peer-reviewed]
English, Scientific journal

Long-term stress distribution patterns of the ankle joint in varus knee alignment assessed by computed tomography osteoabsorptiometry
Tomohiro Onodera, Tokifumi Majima, Norimasa Iwasaki, Tamotsu Kamishima, Yasuhiko Kasahara, Akio Minami
INTERNATIONAL ORTHOPAEDICS, 36, 9, 1871, 1876, Sep. 2012, [Peer-reviewed]
English, Scientific journal

Interruption of glycosphingolipid synthesis enhances osteoarthritis development in mice
Naoki Seito, Tadashi Yamashita, Yukinori Tsukuda, Yuichiro Matsui, Atsushi Urita, Tomohiro Onodera, Takeomi Mizutani, Hisashi Haga, Naoki Fujitani, Yasuro Shinohara, Akio Minami, Norimasa Iwasaki
ARTHRITIS AND RHEUMATISM, 64, 8, 2579, 2588, Aug. 2012, [Peer-reviewed]
English, Scientific journal

Ganglioside GM3 Has an Essential Role in the Pathogenesis and Progression of Rheumatoid Arthritis
Yukinori Tsukuda, Norimasa Iwasaki, Naoki Seito, Masashi Kanayama, Naoki Fujitani, Yasuro Shinohara, Yasuhiko Kasahara, Tomohiro Onodera, Koji Suzuki, Tsuyoshi Asano, Akio Minami, Tadashi Yamashita
PLOS ONE, 7, 6, e40136, Jun. 2012, [Peer-reviewed]
English, Scientific journal

Repair of Rabbit Osteochondral Defects by an Acellular Technique with an Ultrapurified Alginate Gel Containing Stromal Cell-Derived Factor-1
Atsushi Sukegawa, Norimasa Iwasaki, Yasuhiko Kasahara, Tomohiro Onodera, Tatsuya Igarashi, Akio Minami
TISSUE ENGINEERING PART A, 18, 9-10, 934, 945, May 2012, [Peer-reviewed]
English, Scientific journal

Effect of the Japanese herbal medicine, Boiogito, on the osteoarthritis of the knee with joint effusion
Tokifumi Majima, Masahiro Inoue, Yasuhiko Kasahara, Tomohiro Onodera, Daisuke Takahashi, Akio Minami
Sports Medicine, Arthroscopy, Rehabilitation, Therapy and Technology, 4, 1, 3, 10 Jan. 2012, [Peer-reviewed]
English, Scientific journal

Risk of Deep Venous Thrombosis in Drain Clamping With Tranexamic Acid and Carbazochrome Sodium Sulfonate Hydrate in Total Knee Arthroplasty
Tomohiro Onodera, Tokifumi Majima, Naohiro Sawaguchi, Yasuhiko Kasahara, Takayuki Ishigaki, Akio Minami
JOURNAL OF ARTHROPLASTY, 27, 1, 105, 108, Jan. 2012, [Peer-reviewed]
English, Scientific journal

Alterations of High-Mannose Type N-Glycosylation in Human and Mouse Osteoarthritis Cartilage
Atsushi Urita, Tomoya Matsuhashi, Tomohiro Onodera, Hiroaki Nakagawa, Megumi Hato, Maho Amano, Naoki Seito, Akio Minami, Shin-Ichiro Nishimura, Norimasa Iwasaki
ARTHRITIS AND RHEUMATISM, 63, 11, 3428, 3438, Nov. 2011, [Peer-reviewed]
English, Scientific journal

Metal on metal THA後にALVALを生じた1例　　　　　　　　　　　　　　　
清水 智弘, 井上 正弘, 沢口 直弘, 渡部 琢哉, 笠原 靖彦, 小野寺 智洋, 高橋 大介, 安藤 亮, 三浪 明男, 春藤 基之, 菅野 大己, 増田 武志
北海道整形災害外科学会雑誌, 52, 2, 348, 348, 北海道整形災害外科学会, Mar. 2011
Japanese

Btbd7 Regulates Epithelial Cell Dynamics and Branching Morphogenesis
Tomohiro Onodera, Takayoshi Sakai, Jeff Chi-feng Hsu, Kazue Matsumoto, John A. Chiorini, Kenneth M. Yamada
SCIENCE, 329, 5991, 562, 565, Jul. 2010, [Peer-reviewed]
English, Scientific journal

人工股関節置換術術後に偽腫瘍を生じた1例　　　　　　　　　　　　　　　
清水 智弘, 井上 正弘, 渡部 琢哉, 沢口 直弘, 笠原 靖彦, 小野寺 智洋, 高橋 大介, 安藤 亮, 三浪 明男, 眞島 任史, 武田 直樹
日本整形外科学会雑誌, 84, 6, S920, S920, (公社)日本整形外科学会, Jun. 2010
Japanese

Cleft Formation and Branching morphogenesis of Salivary Gland: Exploration of New Functional Genes.
Sakai T, Onodera T, Yamada KM
Interface Oral Health Science, 2009, 1, 13, 19, 2010, [Peer-reviewed]
English, Scientific journal

Local Upregulation of Stromal Cell-Derived Factor-1 After Ligament Injuries Enhances Homing Rate of Bone Marrow Stromal Cells in Rats
Kazumi Shimode, Norimasa Iwasaki, Tokifumi Majima, Tadanao Funakoshi, Naohiro Sawaguchi, Tomohiro Onodera, Akio Minami
TISSUE ENGINEERING PART A, 15, 8, 2277, 2284, Aug. 2009, [Peer-reviewed]
English, Scientific journal

Embryonic organ culture.
Takayoshi Sakai, Tomohiro Onodera
Current protocols in cell biology, Chapter 19, Unit 19.8, Dec. 2008, [Peer-reviewed], [International Magazine]
English, This unit provides detailed protocols for dissecting embryonic organs and performing organ culture to study questions in developmental biology. Procedures are described here for dissecting organs such as kidney, lung, and salivary gland. The unit also contains commentary including troubleshooting for embryonic organ culture.

Patterned Immobilization of Unprotected Carbohydrates on an Aminooxy Polymer-Grafted Solid Surface
Ryosuke Kamitani, Kenichi Niikura, Tomohiro Onodera, Norimasa Iwasaki, Hideyuki Shimaoka, Kuniharu Ijiro
Bulletin of the Chemical Society of Japan, 80, 9, 433, 439, Chemical Society of Japan, Aug. 2007, [Peer-reviewed]
English, Scientific journal

Bone marrow stromal cells act as feeder cells for tendon fibroblasts through soluble factors
Kazumi Shimode, Norimasa Iwasaki, Tokifumi Majima, Tadanao Funakoshi, Naohiro Sawaguchi, Tomohiro Onodera, Akio Minami
TISSUE ENGINEERING, 13, 2, 333, 341, Feb. 2007, [Peer-reviewed]
English, Scientific journal

Specific cell behavior of human fibroblast onto carbohydrate surface detected by glycoblotting films
Tomohiro Onodera, Kenichi Niikura, Norimasa Iwasaki, Noriko Nagahori, Hideyuki Shimaoka, Ryusuke Kamitani, Tokifumi Majima, Akio Minami, Shin-Ichiro Nishimura
BIOMACROMOLECULES, 7, 11, 2949, 2955, Nov. 2006, [Peer-reviewed]
English, Scientific journal

Extracellular matrix modulates expression of cell-surface proteoglycan genes in fibroblasts
Naohiro Sawaguchi, T. Majima, N. Iwasaki, T. Funakoshi, K. Shimode, T. Onodera, A. Minami
Connective Tissue Research, 47, 3, 141, 148, May 2006, [Peer-reviewed]
English, Scientific journal

High density sugar-displaying materials using the glycoblotting methods for cell patterning　　　　　　　　　　　　　　　
Ryosuke Kamitani, Kenichi Niikura, Tomohiro Onodera, Norimasa Iwasaki, Masataka Fumoto, Hideyuki Shimaoka, Kuniharu Ijiro, Shin-Ichiro Nishimura
Polymer Preprints, Japan, 55, 1, 1895, 2006
Japanese, International conference proceedings

遠隔転移を有する原発性悪性骨腫瘍において原発巣切除は生存を改善するか? 米国SEERデータベースを用いた研究
福田 龍一, 松岡 正剛, 小野寺 智洋, 岩崎 浩司, 江畑 拓, 濱崎 雅成, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 98, 2, S94, S94, Mar. 2024
(公社)日本整形外科学会, Japanese

内側型変形性膝関節症および膝蓋大腿関節症に対する組み合わせ式二顆置換術(BiKA)の術後10年成績
馬場 力哉, 大越 康充, 前田 龍智, 岩館 茜, 岩崎 浩司, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 98, 2, S168, S168, Mar. 2024
(公社)日本整形外科学会, Japanese

農業従事者における変形性膝関節症に対する手術加療の短期成績 膝周囲骨切り術と人工膝関節全置換術の比較
上徳 善太, 横山 慎, 小林 悠人, 下田 康平, 福井 隆史, 太田 光俊, 本宮 真, 安井 啓悟, 小野寺 智洋, 岩崎 倫政, 日本整形外科学会雑誌, 98, 2, S190, S190, Mar. 2024
(公社)日本整形外科学会, Japanese

足部に発生した原発性悪性骨腫瘍の生存解析 SEER databaseを用いた研究
松岡 正剛, 小野寺 智洋, 岩崎 浩司, 濱崎 雅成, 江畑 拓, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 98, 2, S277, S277, Mar. 2024
(公社)日本整形外科学会, Japanese

脛骨関節面の骨密度分布に半月板逸脱と下肢アライメントが与える影響
佐藤 知哉, 岩崎 浩司, 濱崎 雅成, 鈴木 裕貴, 松岡 正剛, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 98, 2, S399, S399, Mar. 2024
(公社)日本整形外科学会, Japanese

80歳以上高齢者に発生した四肢発生軟部肉腫における放射線照射
松岡 正剛, 小野寺 智洋, 岩崎 浩司, 濱崎 雅成, 江畑 拓, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 98, 2, S415, S415, Mar. 2024
(公社)日本整形外科学会, Japanese

女性乳がんサブタイプ分類が骨転移症例における生存へ与える影響 米国SEERデータベースを用いた研究
松岡 正剛, 木津谷 菜悠, 小野寺 智洋, 横田 勲, 岩崎 浩司, 濱崎 雅成, 江畑 拓, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 98, 2, S417, S417, Mar. 2024
(公社)日本整形外科学会, Japanese

コラーゲン膜を用いた自家培養軟骨移植の臨床成績 骨膜被覆との比較
甲斐原 拓真, 近藤 英司, 濱崎 雅成, 江畑 拓, 原 健人, 岩崎 浩司, 松岡 正剛, 小野寺 智洋, 門間 太輔, 岩崎 倫政, 日本整形外科学会雑誌, 98, 2, S448, S448, Mar. 2024
(公社)日本整形外科学会, Japanese

外反膝に対して行った内側閉鎖式大腿骨遠位内反骨切り術の成績と膝蓋大腿関節のバイオメカニクスに与える影響
濱崎 雅成, 松岡 正剛, 岩崎 浩司, 鈴木 裕貴, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 井上 雅之, 八木 知徳, 安田 和則, 日本関節病学会誌, 43, 1, 63, 71, Mar. 2024
(一社)日本関節病学会, Japanese

継代細胞における糖鎖シグネチャーの解明
宝満健太郎, 徳廣泰貴, 小野寺智洋, 江畑拓, ALAA Terkawi, 松岡正剛, 花松久寿, 古川潤一, 角家健, 岩崎倫政, 北海道整形災害外科学会, 143rd, 2024

同位体標識水による関節軟骨内水動態の可視化
松ヶ崎圭純, 小野寺智洋, 宝満健太郎, 細川吉暁, 松岡正剛, 福田龍一, 坂井裕子, 劉越, 岩崎倫政, 亀田浩之, 工藤與亮, 坂本直哉, 北海道整形災害外科学会, 143rd, 2024

Comprehensive Analysis of Novel N-Glycan Biomarkers in Serum of Osteoarthritis Patients and Their Clinical Significance
小野寺智洋, 宝満健太郎, 花松久寿, 古川潤一, 岩崎浩司, 松岡正剛, 濱崎雅成, 江畑拓, 細川吉暁, 近藤英司, 岩崎倫政, 日本関節病学会誌(Web), 43, 2, 2024

Histological Observation of Water Dynamics in Articular Cartilage Using Isotope Microscopy
松ヶ崎圭純, 小野寺智洋, 宝満健太郎, 亀田浩之, 亀田浩之, 工藤與亮, 坂本直哉, 細川吉暁, 松岡正剛, 福田龍一, 坂井裕子, 劉越, 岩崎倫政, 日本関節病学会誌(Web), 43, 2, 2024

エビデンスに基づくCKD診療ガイドライン2023　　　　　　　　　　　　　　　
丸山 彰一, 神田 英一郎, 久米 真司, 猪阪 善隆, 石倉 健司, 臼井 丈一, 内田 啓子, 岡田 浩一, 今田 恒夫, 斎藤 知栄, 鈴木 仁, 田中 哲洋, 坪井 直毅, 中川 直樹, 西尾 妙織, 深水 圭, 本田 浩一, 升谷 耕介, 横山 啓太郎, 和田 淳, 和田 隆志, 和田 健彦, 淺沼 克彦, 旭 浩一, 阿部 雅紀, 石本 卓嗣, 川浪 大治, 駒場 大峰, 佐田 憲映, 祖父江 理, 仲谷 慎也, 中司 敦子, 日比野 聡, 藤井 秀毅, 星野 純一, 細島 康宏, 前嶋 明人, 丸山 之雄, 森山 能仁, 安田 日出夫, 安田 宜成, 山本 卓, 石川 英二, 市川 大介, 伊藤 健太, 岩下 山連, 上田 誠二, 上田 裕之, 上村 治, 江里口 雅裕, 大島 恵, 大矢 昌樹, 岡本 孝之, 小口 英世, 小野寺 正輝, 貝藤 裕史, 忰田 亮平, 片山 鑑, 金子 佳代子, 上條 祐司, 神谷 雅人, 唐澤 一徳, 川口 武彦, 川嶋 聡子, 神田 祥一郎, 菅野 義彦, 菊池 洋平, 木原 正夫, 金口 翔, 栗田 宜明, 桑原 頌治, 桑原 孝成, 小泉 賢洋, 河野 圭志, 小坂 志保, 後藤 俊介, 坂口 悠介, 佐藤 隆太, 佐藤 涼介, 座間味 亮, 重冨 奈穂子, 柴田 茂, 島袋 渡, 清水 さやか, 新家 俊郎, 杉本 圭相, 杉本 俊郎, 孫 大輔, 高井 奈美, 田口 博基, 竹内 裕紀, 辰元 為仁, 田中 健一, 田邉 起, 田村 功一, 辻 章志, 辻田 誠, 寺野 千香子, 遠山 直志, 戸田 晋, 永井 恵, 中沢 大悟, 長洲 一, 中野 敏昭, 長浜 正彦, 中屋 来哉, 西 健太朗, 西脇 宏樹, 延山 理恵, 花房 規男, 濱崎 祐子, 濱田 陸, 樋口 一世, 深町 大介, 藤井 直彦, 藤崎 毅一郎, 程内 栄子, 本田 崇, 毎熊 政行, 松木 孝樹, 三浦 健一郎, 三崎 太郎, 水野 智博, 三村 洋美, 宮本 聡, 宮脇 義亜, 牟田 久美子, 村田 智博, 谷澤 雅彦, 柳原 剛, 矢野 裕一朗, 山岸 昌一, 横井 秀基, 吉崎 健, 脇 大輔, 渡邊 博志, 渡辺 博文, 渡辺 昌文, 朝比奈 悠太, 畔上 達彦, 飯田 倫理, 井口 昭, 井口 智洋, 井熊 大輔, 石井 輝, 石塚 喜世伸, 泉 裕一郎, 板野 精之, 市川 大介, 市川 一誠, 伊藤 雄伍, 伊藤 辰将, 内田 大介, 大熊 輝之, 大田 南欧美, 大西 康博, 大野 祥子, 大畑 拓也, 大山 勝宏, 岡 香奈子, 岡 樹史, 緒方 浩顕, 小田 圭子, 小田 直樹, 小原 由紀, 梶保 祐子, 梶本 幸男, 片桐 大輔, 蒲澤 秀門, 神吉 智子, 亀井 啓太, 川口 祐輝, 河原崎 宏雄, 木村 浩, 工藤 光介, 黒岡 直子, 桑形 尚吾, 高上 紀之, 古志 衣里, 近藤 悠希, 齋木 良介, 齋藤 友広, 齋藤 浩孝, 佐々木 彰, 佐藤 浩司, 猿渡 淳二, 志田 龍太郎, 菅原 亮佑, 鈴木 克彦, 諏訪部 達也, 平 大樹, 高士 祐一, 武田 尚子, 武田 有記, 田中 茂, 田中 祥子, 谷口 美紗, 塚本 俊一郎, 鶴田 悠木, 寺下 真帆, 土井 洋平, 徳永 孝史, 泊 弘毅, 鳥越 健太, 内藤 順子, 中井 健太郎, 長岡 由女, 中川 詩織, 中川 輝政, 中島 章雄, 中島 悠里, 永田 大, 永野 伸郎, 中村 祐貴, 永山 泉, 西沢 慶太郎, 西堀 暢浩, 忍頂寺 毅史, 服部 洸輝, 花井 豪, 濱田 昌実, 原田 真, 春原 浩太郎, 平井 健太, 平林 陽介, 福田 俊悟, 藤澤 諭, 藤丸 拓也, 堀越 慶輔, 本城 保菜美, 松尾 浩司, 丸山 啓介, 宮内 隆政, 宮崎 絋平, 武藤 正浩, 村島 美穂, 矢野 彰三, 山内 壮作, 山口 哲志, 山田 俊輔, 山原 康佑, 山本 脩人, 山脇 正裕, 湯浅 貴博, 吉田 学郎, 芦村 龍一, 若林 華恵, 若松 拓也, 渡邉 公雄, 渡邉 健太郎, 渡邉 周平, 小杉 智規, 日本腎臓学会, 日本腎臓学会誌, 66, 1, i,1, 259, Jan. 2024
(一社)日本腎臓学会, Japanese

変形性膝関節症の重症度別外的膝関節モーメント成分の寄与率変化の検討
鈴木 裕貴, 小野寺 智洋, 岩崎 倫政, 大越 康充, 前田 龍智, 川上 健作, 清水 健太, 千田 周也, 浮城 健吾, 岩崎 浩司, 鈴木 昭二, 近藤 英司, 日本関節病学会誌, 42, 4, 340, 346, Dec. 2023
(一社)日本関節病学会, Japanese

Functional analysis of glycans in the regulatory mechanism of cartilage degeneration to elucidate the mechanism of osteoarthritis pathogenesis
松岡正剛, 小野寺智洋, 岩崎倫政, 整形・災害外科, 66, 12, 1459, 1463, Nov. 2023
金原出版(株), Japanese

遺伝性低リン血症性くる病患者に対するブロスマブ投与による下肢アライメント改善効果の検討　　　　　　　　　　　　　　　
坂井 裕子, 小野寺 智洋, 松岡 正剛, 中村 明枝, 岩崎 倫政, 日本小児整形外科学会雑誌, 32, 3, S111, S111, Nov. 2023
(一社)日本小児整形外科学会, Japanese

【整形外科外来Red Flags 2023】膝関節痛のRed Flags 非外傷
小野寺 智洋, Orthopaedics, 36, 10, 205, 211, Oct. 2023
(株)全日本病院出版会, Japanese

重症頭部外傷慢性期患者の口腔内特徴についての放射線学的検証
児島 美智子, 安中 恵, 吹野 茉里奈, 村上 久美子, 八巻 智洋, 小野寺 晋志, 伊東 大祐, 小瀧 勝, 小林 繁樹, The Japanese Journal of Rehabilitation Medicine, 60, 秋季特別号, S504, S504, Oct. 2023
(公社)日本リハビリテーション医学会, Japanese

広範な膝軟骨損傷に対するアテロコラーゲンを用いた自家培養軟骨移植術後の活動レベルの変化
甲斐原 拓真, 近藤 英司, 小野寺 智洋, 門間 太輔, 岩崎 倫政, 日本臨床スポーツ医学会誌, 31, 4, S300, S300, Oct. 2023
(一社)日本臨床スポーツ医学会, Japanese

四肢原発悪性骨腫瘍症例における患肢温存術と切断術の比較 米国SEERデータベースを用いた研究
柳澤 那由他, 松岡 正剛, 小野寺 智洋, 岩崎 浩司, 鈴木 裕貴, 濱崎 雅成, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 97, 8, S1887, S1887, Aug. 2023
(公社)日本整形外科学会, Japanese

診断時遠隔転移を有する四肢発生原発性悪性骨腫瘍の原発巣切除が生存に与える影響 米国SEERデータベースを用いた研究
福田 龍一, 松岡 正剛, 小野寺 智洋, 岩崎 浩司, 鈴木 裕貴, 濱崎 雅成, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 97, 8, S1888, S1888, Aug. 2023
(公社)日本整形外科学会, Japanese

遠隔転移を有する軟部肉腫症例において原発巣切除は生存を延長する SEERデータベースを用いた研究
松岡 正剛, 小野寺 智洋, 横田 勲, 岩崎 浩司, 松原 新史, 菱村 亮介, 近藤 英司, 岩崎 倫政, 北海道整形災害外科学会雑誌, 64, 2, 49, 58, Mar. 2023
北海道整形災害外科学会, Japanese

大腿骨顆間外側壁における骨密度分布-前十字靱帯の大腿骨付着部に関する考察-
菅原悠太郎, 岩崎浩司, 遠藤香織, 菱村亮介, 松原新史, 松岡正剛, 門間太輔, 小野寺智洋, 近藤英司, 岩崎倫政, 日本整形外科学会雑誌, 97, 2, 2023

3次元Computed Tomographyを用いた内側楔状開大式高位脛骨骨切り術前後の膝蓋骨高位の評価
土橋晋也, 岩崎浩司, 塩田惇喜, 門間太輔, 菱村亮介, 小野寺智洋, 近藤英司, 岩崎倫政, 東日本整形災害外科学会雑誌(Web), 35, 3, 2023

高純度アルギン酸ゲルを用いた運動器再生医療開発
小野寺智洋, 門間太輔, 馬場力哉, 松岡正剛, 岩崎浩司, 山口純, 斎藤充, 長濱宏治, 岩崎倫政, 日本整形外科学会雑誌, 97, 8, 2023

肘軟骨損傷に対する再生治療アプローチ-硝子様軟骨による修復・再生を目指して-
門間太輔, 近藤英司, 小野寺智洋, 岩崎倫政, 日本整形外科学会雑誌, 97, 8, 2023

三次元動作解析による内側型変形性膝関節症患者におけるVarus Thrustの運動学的特徴の検討
岩崎浩司, 大越康充, 館山唯, 三浦浩太, 浮城健吾, 川上健作, 鈴木昭二, 小野寺智洋, 近藤英司, 岩崎倫政, 日本整形外科学会雑誌, 97, 8, 2023

高位脛骨骨切り術後の非術側膝の生体工学的変化
岩崎浩司, 大越康充, 笹谷一輝, 櫻井茂幸, 浮城健吾, 川上健作, 鈴木昭二, 前田龍智, 小野寺智洋, 近藤英司, 岩崎倫政, 日本整形外科学会雑誌, 97, 8, 2023

脛骨関節面の軟骨下骨の骨密度分布に関わる半月板逸脱の評価方法の検討
岩崎浩司, 佐藤知哉, 濱崎雅成, 鈴木裕貴, 小野寺智洋, 近藤英司, 岩崎倫政, 日本整形外科学会雑誌, 97, 8, 2023

内側閉鎖式大腿骨遠位内反骨切り術が大腿脛骨関節の応力分布に与える効果-CT osteoabsorptiometry法を用いた検討-
濱崎雅成, 近藤英司, 鈴木裕貴, 松岡正剛, 岩崎浩司, 小野寺智洋, 井上雅之, 安田和則, 八木知徳, 岩崎倫政, 日本整形外科学会雑誌, 97, 8, 2023

高純度アルギン酸ゲル移植術後3年の臨床成績の検討
小野寺智洋, 門間太輔, 松岡正剛, 岩崎浩司, 近藤英司, 鈴木孝治, 井上雅之, 岩崎倫政, 日本整形外科学会雑誌, 97, 8, 2023

脛骨関節面の骨密度分布に半月板逸脱と下肢アライメントが与える影響
岩崎浩司, 佐藤知哉, 濱崎雅成, 鈴木裕貴, 松岡正剛, 小野寺智洋, 近藤英司, 岩崎倫政, 日本整形外科学会雑誌, 97, 8, 2023

変形性膝関節症の重症度別外的膝関節モーメント成分の寄与率変化の検討
鈴木裕貴, 鈴木裕貴, 小野寺智洋, 岩崎倫政, 大越康充, 前田龍智, 川上健作, 清水健太, 千田周也, 浮城健吾, 岩崎浩司, 鈴木昭二, 近藤英司, 日本関節病学会誌(Web), 42, 4, 2023

踵骨を含めた下肢アライメントX線画像評価と膝関節内反モーメントの関係
塩田惇喜, 塩田惇喜, 大越康充, 井上貴博, 浮城健吾, 川上健作, 前田龍智, 岩崎浩司, 岩崎浩司, 小野寺智洋, 近藤英司, 岩崎倫政, 日本足の外科学会雑誌, 44, Supplement, 2023

重度外反母趾変形に対してParallel cut deviceを用いたLapidus変法の臨床成績の検討
小野寺智洋, 松岡正剛, 岩崎浩司, 甲斐原拓真, 濱崎雅成, 江畑拓, 原健人, 近藤英司, 岩崎倫政, 日本足の外科学会雑誌, 44, Supplement, 2023

変形性膝関節症患者における歩行中の膝関節内側荷重量とKinematicsの関連
佐橋健人, 渡邊謙太郎, 千徳風真, 千葉健, 岩崎浩司, 小野寺智洋, 岩崎倫政, 近藤英司, 遠山晴一, 北海道整形災害外科学会, 142nd, 2023

Mechanisms of tendon tissue repair using alginate-cell cross-linked gel
山口純, 山口純, 小野寺智洋, 宝満健太郎, 松岡正剛, 長濱宏冶, 上田菜摘, 澤田志穂, 斎藤充, 岩崎倫政, 日本バイオマテリアル学会大会予稿集(Web), 45th, 267, 267, 2023
日本バイオマテリアル学会, Japanese

アルギン酸-細胞間架橋ゲルによる腱組織修復機序の解明
山口純, 山口純, 小野寺智洋, 宝満健太郎, 松岡正剛, 長濱宏治, 上田菜摘美, 澤田志穂, 斎藤充, 岩崎倫政, 日本整形外科学会雑誌, 97, 8, 2023

ケモカイン受容体CCR7欠損は小児骨端線損傷後における成長抑制を予防する
松岡正剛, 金佑泳, 坂井裕子, 福田龍一, 松ヶ崎圭純, 宝満健太郎, 小野寺智洋, 岩崎倫政, 日本整形外科学会雑誌, 97, 8, 2023

Mechanisms of tendon tissue repair using alginate-cell cross-linked gel
山口純, 山口純, 小野寺智洋, 宝満健太郎, 松岡正剛, 長濱宏冶, 上田菜摘美, 澤田志穂, 斎藤充, 岩崎倫政, 日本軟骨代謝学会プログラム・抄録集, 35th, 2023

Intercomparison of all glycans expressed in osteoarthritic cartilage
宝満健太郎, 小野寺智洋, 花松久寿, 古川潤一, 松ヶ崎圭純, LIU Yue, KIM WooYoung, 松岡正剛, 岩崎倫政, 日本軟骨代謝学会プログラム・抄録集, 35th, 2023

広範な膝軟骨欠損に対するアテロコラーゲンを用いた自家培養軟骨移植の中期臨床成績
甲斐原拓真, 濱崎雅成, 鈴木裕貴, 松岡正剛, 小野寺智洋, 岩崎倫政, 近藤英司, 岩崎浩司, 小田義崇, 種井善一, 田中伸哉, 北海道整形災害外科学会, 142nd, 2023

膝軟骨欠損に対するアテロコラーゲンを用いた自家培養軟骨移植の臨床成績-3年以上経過例について
甲斐原拓真, 近藤英司, 濱崎雅成, 鈴木裕貴, 岩崎浩司, 松岡正剛, 小野寺智洋, 小田義崇, 種井善一, 田中伸哉, 岩崎倫政, 整形外科バイオマテリアル研究会プログラム・抄録集, 41st, 2022

アルギン酸-細胞間架橋ゲルによる腱組織修復効果の検討
山口純, 山口純, 小野寺智洋, 宝満健太郎, 松岡正剛, 細川吉暁, 岩崎倫政, 斎藤充, 長濱宏治, 上田菜摘美, 澤田志穂, 日本整形外科学会雑誌, 96, 8, 2022

酸素-17安定同位体標識水を水トレーサーとして用いたMRIによる関節軟骨病変評価法の確立
細川吉暁, 小野寺智洋, 亀田浩之, 宝満健太郎, 山口純, 工藤與亮, 杉森博之, 岩崎倫政, 日本整形外科学会雑誌, 96, 8, 2022

総合グライコミクスアプローチによる変形性関節症標的分子の探索
宝満健太郎, 小野寺智洋, 花松久寿, 古川潤一, 山口純, 細川吉暁, 金佑泳, 松岡正剛, 岩崎倫政, 日本整形外科学会雑誌, 96, 8, 2022

軟骨統合グライコミクスによる変形性関節症標的因子の探索
宝満健太郎, 小野寺智洋, 花松久寿, 古川潤一, 山口純, 細川吉暁, 松ヶ崎圭純, 金佑泳, 松岡正剛, 岩崎倫政, 北海道整形災害外科学会, 141st, 2022

¹⁷O標識水を水トレーサーとして用いたMRIによる関節軟骨病変評価法の確立
細川吉暁, 小野寺智洋, 宝満健太郎, 工藤與亮, 亀田浩之, 杉森博行, 北海道整形災害外科学会, 141st, 2022

O-17標識水を水トレーサーとして用いたMRIによる関節軟骨病変評価法の確立
細川吉暁, 小野寺智洋, 宝満健太郎, 工藤與亮, 亀田浩之, 杉森博之, 岩崎倫政, 日本整形外科学会雑誌, 96, 2, 2022

アルギン酸-細胞間架橋ゲルを用いた腱組織修復の検討
山口純, 山口純, 小野寺智洋, 宝満健太郎, 長濱宏冶, 上田菜摘美, 澤田志穂, 斎藤充, 岩崎倫政, 日本整形外科学会雑誌, 96, 3, 2022

Tendon tissue repair using alginate-cell cross-linked gel
山口純, 山口純, 小野寺智洋, 宝満健太郎, 細川吉暁, 長濱宏冶, 上田菜摘美, 澤田志穂, 斎藤充, 岩崎倫政, 日本軟骨代謝学会プログラム・抄録集, 34th, 2022

Deficiency of fucosylated glycan in articular cartilage inhibits recovery from damage and promotes cartilage degeneration
宝満健太郎, 小野寺智洋, 花松久寿, 古川潤一, 宮崎拓自, 山口純, 細川吉暁, LIANG Dawei, KIM Woo Young, 江畑拓, 木村洋介, 松岡正剛, 岩崎倫政, 日本軟骨代謝学会プログラム・抄録集, 34th, 2022

大腿骨顆間窩外側壁における骨密度分布:前十字靱帯の大腿骨付着部に関する考察
菅原悠太郎, 遠藤香織, 菱村亮介, 松原新史, 松岡正剛, 小野寺智洋, 岩崎倫政, 岩崎浩司, 門間大輔, 近藤英司, 北海道整形災害外科学会, 139th, 2021

大腿骨顆間外側壁における骨密度分布:前十字靱帯の大腿骨付着部についての考察
菅原悠太郎, 岩崎浩司, 遠藤香織, 菱村亮介, 松原新史, 松岡正剛, 門間太輔, 小野寺智洋, 近藤英司, 岩崎倫政, 日本整形外科学会雑誌, 95, 8, 2021

細胞特異的糖鎖解析による定量評価を応用した未分化iPS細胞除去条件の最適化
宮崎拓自, 小野寺智洋, 花松久寿, 古川潤一, 宝満健太郎, 川嵜敏祐, 岩崎倫政, 日本整形外科学会雑誌, 95, 8, 2021

マウス成長板軟骨損傷後にb-seriesガングリオシドが果たす役割
細川吉暁, 松岡正剛, 小野寺智洋, 宝満健太郎, 金佑泳, 岩崎倫政, 日本整形外科学会雑誌, 95, 8, 2021

アルギン酸-細胞間架橋ゲルを用いた腱組織修復の検討
山口純, 山口純, 小野寺智洋, 宝満健太郎, 長濱宏治, 上田菜摘美, 澤田志穂, 斎藤充, 岩崎倫政, 日本整形外科学会雑誌, 95, 8, 2021

Tendon tissue repair using alginate-cell cross-linked gel
山口純, 山口純, 小野寺智洋, 宝満健太郎, 細川吉暁, 長濱宏治, 上田菜摘美, 澤田志穂, 斎藤充, 岩崎倫政, 整形外科バイオマテリアル研究会プログラム・抄録集, 40th, 2021

マウス成長板軟骨損傷後に糖脂質ガングリオシドが果たす役割
細川吉暁, 松岡正剛, 小野寺智洋, 宝満健太郎, 金佑泳, 岩崎倫政, 北海道整形災害外科学会, 140th, 2021

変形性膝関節症症例におけるウェアラブルセンサーを用いた歩行評価時の最適なセンサー貼付位置の検討
佐橋 健人, 千葉 健, 岩崎 浩司, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 遠山 晴一, 北海道整形災害外科学会雑誌, 63, 139th suppl, 35, 35, 2021
北海道整形災害外科学会, Japanese

軟骨のコアフコシル化の喪失は変性からの修復を妨げ変形性関節症を早期化する
宝満健太郎, 小野寺智洋, 濱崎雅成, 徐亮, 宮崎拓自, 山口純, 細川吉暁, 江畑拓, 梁大偉, 金佑泳, 岩崎倫政, 古川潤一, 花松久寿, 北海道整形災害外科学会, 139th, 2021

細胞特異的糖鎖解析の手法を用いた残存未分化iPS細胞の定量的評価法の確立
宮崎拓自, 小野寺智洋, 徐亮, 宝満健太郎, 岩崎倫政, 花松久寿, 古川潤一, 北海道整形災害外科学会, 139th, 2021

Protective Role of Optineurin Against Joint Destruction in Rheumatoid Arthritis Synovial Fibroblasts.
Wen Shi Lee, Masaru Kato, Eri Sugawara, Michihiro Kono, Yuki Kudo, Michihito Kono, Yuichiro Fujieda, Toshiyuki Bohgaki, Olga Amengual, Kenji Oku, Shinsuke Yasuda, Tomohiro Onodera, Norimasa Iwasaki, Tatsuya Atsumi, Arthritis & rheumatology (Hoboken, N.J.), 72, 9, 1493, 1504, Sep. 2020, [International Magazine]
OBJECTIVE: Optineurin (OPTN) is an autophagy adaptor/receptor that acts as an intrinsic negative regulator of osteoclast differentiation. RANKL expressed by rheumatoid arthritis synovial fibroblasts (RASFs) is primarily responsible for the development of bone erosions in patients with RA. The aim of the present study was to explore the role of OPTN in the pathogenesis of joint destruction in RA. METHODS: RASFs were left untreated or incubated with tumor necrosis factor (TNF) or interferon-γ (IFNγ), and expression of OPTN by RASFs was analyzed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Western blotting. Expression of RANKL and osteoprotegerin (OPG) was evaluated in cultures of OPTN-reduced RASFs with or without TNF or IFNγ treatment. OPTN-reduced RASFs were cocultured with monocytes and stained for tartrate-resistant acid phosphatase (TRAP). IκBα, NF-κB1, and RelA protein levels were measured to evaluate NF-κB signaling. Expression of messenger RNA (mRNA) for matrix metalloproteinase 3 (MMP3), interleukin-6 (IL6), GATA binding protein 3 (GATA3), carbohydrate sulfotransferase 15 (CHST15), hyaluronan synthase 1 (HAS1), and GATA1 was analyzed by RT-qPCR. RESULTS: In RASFs incubated with TNF or IFNγ, OPTN expression was up-regulated and RANKL expression was increased, and these effects were further pronounced in OPTN-reduced RASFs (all P < 0.05 versus controls). OPG mRNA levels remained unchanged. Monocytes cocultured with OPTN-reduced RASFs differentiated to a greater extent into TRAP+ multinucleated cells compared to monocytes cocultured with control RASFs (P < 0.05). IκBα degradation and nuclear NF-κB1 expression following TNF treatment were both prolonged in OPTN-reduced RASFs (each P < 0.05 versus controls). MMP3 mRNA levels were up-regulated, while GATA3, CHST15, and HAS1 mRNA levels were down-regulated in OPTN-reduced RASFs (each P < 0.05 versus controls). CONCLUSION: OPTN plays a protective role in RA when it is up-regulated in RASFs in the presence of proinflammatory cytokines. Absence of OPTN might worsen RA by generating a joint-destructive state, as indicated by evidence of increased RANKL expression on RASFs and subsequent osteoclast differentiation., English

Glycolipid Expression Analysis Of Chondrocyte-like Cells Derived From Human Induced Pluripotent Stem Cells (hipsc).　　　　　　　　　　　　　　　
Liang Xu, Tomohiro Onodera, Jun-ichi Furukawa, Hisatoshi Hanamatsu, Kentaro Homan, Kazutoshi Hontani, Takuji Miyazaki, Yuan Tian, Norimasa Iwasaki, The 66th Annual Meeting of Orthopaedic Research Society (ORS), 45, PS2-2263, Feb. 2020
English

Elimination Of Residual Ipscs From Derived Chondrocytes By Using A Cytotoxic Antibody Specifically Bound To Ips May Reduce The Risk Of Tumorigenicity.　　　　　　　　　　　　　　　
Takuji Miyazaki, Tomohiro Onodera, Jun-ichi Furukawa, Hisatoshi Hanamatsu, Liang Xu, Kentaro Homan, Toshisuke Kawasaki, Norimasa Iwasaki, The 66th Annual Meeting of Orthopaedic Research Society (ORS), 45, PS2-1549, Feb. 2020
English

Three-dimensional analysis of cell distribution in gel using OCT (Optical Coherence Tomography)
山口純, 小野寺智洋, 宝満健太郎, 岩崎倫政, 丸毛啓史, 日本軟骨代謝学会プログラム・抄録集, 33rd, 2020

OCT(光干渉断層計)を用いたゲル内細胞分布の三次元解析
山口純, 山口純, 小野寺智洋, 宝満健太郎, 岩崎倫政, 丸毛啓史, 斎藤充, 日本整形外科学会雑誌, 94, 8, 2020

骨軟骨欠損に対する高純度アルギン酸ゲルと骨髄穿刺濃縮細胞併用移植の検討　　　　　　　　　　　　　　　
徐 亮, 瓜田 淳, 小野寺 智洋, 菱村 亮介, 宝満 健太郎, 岩崎 倫政, 整形外科バイオマテリアル研究会, 39th, 15, Dec. 2019
Japanese, Summary national conference

OCT（光干渉断層計）を用いたゲル内細胞分布の3次元解析
山口 純, 小野寺 智洋, 宝満 健太郎, 岩崎 倫政, 整形外科バイオマテリアル研究会, 39th, 5, Dec. 2019
Japanese, Summary national conference

半月板修復に寄与する細胞種の探求　　　　　　　　　　　　　　　
宝満 健太郎, 小野寺 智洋, 金 佑泳, 近藤 英司, 岩崎 倫政, 整形外科バイオマテリアル研究会, 39th, 17, Dec. 2019
Japanese, Summary national conference

半月板の再生を司るのは半月板か、滑膜か? －凍結解凍法を用いた家兎半月板損傷モデルの研究 －
宝満 健太郎, 小野寺 智洋, 金 佑泳, 近藤英司, 岩崎 倫政, 第41回日本バイオマテリアル学会大会, 筑波, 8, Nov. 2019

The Selective Removal Method of Undifferentiated iPS Cells Using Specifi c Antibody for Cartilage Regenerative Medicine.
T. Miyazaki, T. Onodera, L. Xu, H. Hanamatsu, J. Furukawa, K. Homan, M. Hamasaki, R. Hishimura, T. Kawasaki, N. Iwasaki, World Congress of International Chemical Reference Substances (ICRS), 15, P174, Oct. 2019

Therapeutic Effect of Ultra-Purified Alginate gel Containing Bone Marrow Aspirate Concentrate on Osteochondral Defects in a Rabbit Model.
L. Xu, A. Urita, T. Onodera, R. Hishimura, M. Hamasaki, D. Liang, Y. Tian, K. Homan, N. Iwasaki, World Congress of International Chemical Reference Substances (ICRS), 15, P083, Oct. 2019

Identification of M9 high-mannose glycan regulating hypertrophy in articular cartilage　　　　　　　　　　　　　　　
K. Homan, T. Onodera, J. Furukawa, H. Hanamatsu, R. Hishimura, K. Wooyoung, M. Hamasaki, L. Xu, N. Iwasaki, World Congress of International Chemical Reference Substances (ICRS), 15, 10.4.8, Oct. 2019

Transcriptional profi ling of murine macrophages stimulated with cartilage fragments reveals a novel mechanism for osteoarthritis.　　　　　　　　　　　　　　　
M. Hamasaki, M.A. Terkawi, T. Onodera, K. Homan, G. Matsumae, Y. Tian, H. Alhasan, T. Ebata, N. Iwasaki, World Congress of International Chemical Reference Substances (ICRS), 15, 12.2.4, Oct. 2019

軟骨再生医療への応用を標的とした未分化iPS細胞特異的除去法の検討　　　　　　　　　　　　　　　
宮崎拓自, 小野寺智洋, 徐亮, 花松久寿, 古川潤一, 宝満健太郎, 川嵜敏祐, 岩崎倫政, 日本運動器移植・再生医学研究会要旨集, 38, Oct. 2019

M9高マンノース型糖鎖は関節軟骨における肥大化を制御する
宝満健太郎, 小野寺智洋, 花松久寿, 古川潤一, 菱村亮介, 金佑泳, 濱崎雅成, 徐亮, 岩崎倫政, 日本整形外科学会雑誌, 93, 8, S1682, S1682, 09 Sep. 2019
(公社)日本整形外科学会, Japanese

軟骨破片に対するマクロファージ炎症反応の網羅的遺伝子発現解析
濱崎雅成, TERKAWI M. Alaa, 小野寺智洋, 宝満健太郎, 徐亮, 宮崎拓自, 田園, 江畑拓, 松前元, 岩崎倫政, 日本整形外科学会雑誌, 93, 8, S1627, S1627, 09 Sep. 2019
(公社)日本整形外科学会, Japanese

軟骨再生医療への応用を標的とした末分化iPS細胞特異的除去法の検討
宮崎拓自, 小野寺智洋, 徐亮, 花松久寿, 古川潤一, 宝満健太郎, 濱崎雅成, 菱村亮介, 川嵜敏祐, 岩崎倫政, 日本整形外科学会雑誌, 93, 8, S1664, S1664, 09 Sep. 2019
(公社)日本整形外科学会, Japanese

骨軟骨欠損に対する骨髄穿刺濃縮細胞と高純度アルギン酸ゲル併用移植の検討
XU L, 瓜田淳, 小野寺智洋, 菱村亮介, 濱崎雅成, 梁大偉, 宝満健太郎, 岩崎倫政, 日本整形外科学会雑誌, 93, 8, S1665, S1665, 09 Sep. 2019
(公社)日本整形外科学会, Japanese

アテロコラーゲンを用いた自家培養軟骨移植の組織学的検討　　　　　　　　　　　　　　　
甲斐原 拓真, 近藤 英司, 岩崎 浩司, 小野寺 智洋, 遠山 晴一, 岩崎 倫政, 安田 和則, 日本整形外科スポーツ医学会雑誌, 39, 4, 469, 469, Aug. 2019
(一社)日本整形外科スポーツ医学会, Japanese

膝十字靱帯不全を伴う内側型変形性膝関節症に対する膝十字靱帯再建術と高位脛骨骨切り術の二期的手術の短期成績　　　　　　　　　　　　　　　
清水 寛和, 岩崎 浩司, 近藤 英司, 小野寺 智洋, 新井 隆太, 上徳 善太, 岩崎 倫政, JOSKAS, 44, 4, 252, 252, May 2019
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

両膝に発生した内側円板状半月板の2例
青木佑介, 岩崎浩司, 近藤英司, 珍部正嗣, 新井隆太, 小野寺智洋, 安田和則, 岩崎倫政, JOSKAS, 44, 2, 336, 337, Apr. 2019
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

人工膝関節全置換術後インプラント周囲感染に対する治療成績の検討
新井隆太, 小野寺智洋, 岩崎浩司, 近藤英司, 岩崎倫政, JOSKAS, 44, 1, 242‐243, 25 Mar. 2019
Japanese

網羅的遺伝子発現解析によるマクロファージに対する軟骨破片の影響の検討
濱崎雅成, TERKAWI Alaa, 小野寺智洋, 宝満健太郎, 菱村亮介, XU Liang, 宮崎拓自, TIAN Yuan, 岩崎倫政, 日本軟骨代謝学会プログラム・抄録集, 32nd, 118, Mar. 2019
Japanese

半月板と滑膜の半月板組織再生への寄与度の比較研究
KIM WooYoung, 小野寺智洋, 近藤英司, 宝満健太郎, 菱村亮介, 岩崎倫政, 日本軟骨代謝学会プログラム・抄録集, 32nd, 88, Mar. 2019
Japanese

軟骨破片マクロファージ共培養モデルにおける軟骨細胞の網羅的遺伝子発現解析
TERKAWI Mohamad Alaa, 濱崎雅成, 小野寺智洋, 宝満健太郎, 菱村亮介, XU Liang, 宮崎卓司, TIAN Yuan, 岩崎倫政, 日本軟骨代謝学会プログラム・抄録集, 32nd, 119, Mar. 2019
Japanese

Total Glycome Analysis Through Chondrocyte Hypertrophy.　　　　　　　　　　　　　　　
Kentaro Homan, Tomohiro Onodera, Jun-ichi Furukawa, Hisatoshi Hanamatsu, Ryosuke Hishimura, WooYoung Kim, Masanari Hamasaki, Liang Xu, Norimasa Iwasaki, The 65th Annual Meeting of Orthopaedic Research Society (ORS), 44, PS2-065, Feb. 2019
English

Which Contributes To Meniscal Regeneration, Synovium Or Meniscus? -in Vivo Rabbit Model Study With Ultrapurified Low Endotoxin Alginate (upal) Gel And Freeze-thaw Method-.
WooYoung Kim, Tomohiro Onodera, Eiji Kondo, Mohamad A. Terkawi, Kentaro Homan, Ryosuku Hishimura, Norimasa Iwasaki, The 65th Annual Meeting of Orthopaedic Research Society (ORS)(New Investigator Recognition Award (NIRA) finalist), 44, 27-154, Feb. 2019
English

軟骨再生医療への応用を標的とした未分化iPS細胞特異的除去法の検討
宮崎拓自, 小野寺智洋, 徐亮, 花松久寿, 古川潤一, 宝満健太郎, 川嵜敏祐, 岩崎倫政, 移植(Web), 54, 4-5, 2019

骨軟骨欠損に対する骨髄穿刺濃縮細胞と高純度アルギン酸ゲル併用移植の検討
徐亮, 瓜田淳, 小野寺智洋, 菱村亮介, 濱崎雅成, 梁大偉, 宝満健太郎, 岩崎倫政, 北海道整形災害外科学会, 137th, 8, 13, S1665, 2019
(公社)日本整形外科学会, Japanese

家兎半月板部分欠損モデルにおける高純度硬化性アルギン酸ゲル移植の半月板修復に与える効果
金佑泳, 小野寺智洋, 近藤英司, 野々山貴行, 馬場力哉, 上徳善太, 宝満健太郎, 菱村亮介, 岩崎倫政, 整形外科バイオマテリアル研究会プログラム・抄録集, 38th, 38, Nov. 2018
Japanese

関節リウマチ患者に対する人工膝関節置換術後深部静脈血栓症の発生頻度
上徳善太, 小野寺智洋, 近藤英司, 岩崎浩司, 馬場力哉, 中條正英, 岩崎倫政, 日本関節病学会誌, 37, 3, 318, 01 Oct. 2018
Japanese

全身性エリテマトーデスにおける骨壊死部位発症頻度の検討
佐藤恒明, 小野寺智洋, 馬場力哉, 上徳善太, 岩崎浩司, 高橋大介, 近藤英司, 藤枝雄一郎, 岩崎倫政, 日本関節病学会誌, 37, 3, 239, 01 Oct. 2018
Japanese

足底腱膜炎:足底腱膜炎の治療における最新の知見 足底腱膜炎に対する治療の変遷　　　　　　　　　　　　　　　
小野寺 智洋, 日本足の外科学会雑誌, 39, Suppl., S314, S314, Oct. 2018
(一社)日本足の外科学会, Japanese

Ilizarov創外固定器を用いた足関節固定術の中期臨床成績の検討　　　　　　　　　　　　　　　
小野寺 智洋, 山崎 修司, 岩崎 浩司, 上徳 善太, 馬場 力哉, 近藤 英司, 岩崎 倫政, 日本足の外科学会雑誌, 39, Suppl., S426, S426, Oct. 2018
(一社)日本足の外科学会, Japanese

強皮症による高度皮膚硬化を合併した前足部変形の1例　　　　　　　　　　　　　　　
松岡 正剛, 小野寺 智洋, 高橋 要, 近藤 英司, 岩崎 倫政, 日本足の外科学会雑誌, 39, Suppl., S451, S451, Oct. 2018
(一社)日本足の外科学会, Japanese

全身性エリテマトーデスにおける骨壊死部位発症頻度の検討　　　　　　　　　　　　　　　
佐藤 恒明, 小野寺 智洋, 馬場 力哉, 上徳 善太, 岩崎 浩司, 高橋 大介, 近藤 英司, 藤枝 雄一郎, 岩崎 倫政, 日本関節病学会誌, 37, 3, 239, 239, Oct. 2018
(一社)日本関節病学会, Japanese

関節リウマチ患者に対する人工膝関節置換術後深部静脈血栓症の発生頻度　　　　　　　　　　　　　　　
上徳 善太, 小野寺 智洋, 近藤 英司, 岩崎 浩司, 馬場 力哉, 中條 正英, 岩崎 倫政, 日本関節病学会誌, 37, 3, 318, 318, Oct. 2018
(一社)日本関節病学会, Japanese

膝屈筋腱ハイブリッド代用材料を用いた2束前十字靱帯再再建術の臨床成績:1束再建との比較
岩崎浩司, 近藤英司, 珍部正嗣, 小野寺智洋, 小野寺純, 八木知徳, 安田和則, 岩崎倫政, 日本整形外科スポーツ医学会雑誌, 38, 4, 432, 31 Aug. 2018
Japanese

重度複合靱帯損傷に対し後外側支持機構修復後,二期的に解剖学的2束ACL・PCL同時再建術を行った一例
細川吉暁, 近藤英司, 珍部正嗣, 岩崎浩司, 小野寺智洋, 安田和則, 岩崎倫政, 日本整形外科スポーツ医学会雑誌, 38, 4, 701, 31 Aug. 2018
Japanese

A Rare Case of Recurrence of Multiple Phosphaturic Mesenchymal Tumors along Flexor Hallucis Longus Tendon Inducing Resurgence of Osteomalacia
新井隆太, 小野寺智洋, 岩崎倫政, 日本足の外科学会雑誌, 39, 1, 245‐249, 31 Aug. 2018
Japanese

新鮮膝重度複合靱帯損傷に対する二期的再建術の短期成績
上徳善太, 岩崎浩司, 近藤英司, 小野寺智洋, 珍部正嗣, 馬場力哉, 安田和則, 岩崎倫政, 日本整形外科スポーツ医学会雑誌, 38, 4, 702, 31 Aug. 2018
Japanese

膝屈筋腱ハイブリッド代用材料を用いた遺残組織温存解剖学的2束前十字靱帯再建術の臨床成績:非温存群との年齢別の検討
江畑拓, 近藤英司, 岩崎浩司, 珍部正嗣, 新井隆太, 小野寺智洋, 小野寺純, 安田和則, 八木知徳, 岩崎倫政, 日本整形外科スポーツ医学会雑誌, 38, 4, 434, 31 Aug. 2018
Japanese

膝軟骨欠損に対するアテロコラーゲンを用いた自家培養軟骨移植の短~中期成績
甲斐原拓真, 亀田敏明, 近藤英司, 小野寺智洋, 薮内康史, 遠山春一, 安田和則, 岩崎倫政, 日本整形外科スポーツ医学会雑誌, 38, 4, 385, 31 Aug. 2018
Japanese

A Questionnaire Survey of Shoes for Rugby Football Taken in the 95th National High School Tournament
杉本和也, 杉本和也, 杉本和也, 荻内隆司, 小野寺智洋, 亀山泰, 鳥居俊, 野口英雄, 橋本健史, 橋本健史, 山門浩太郎, 吉村一朗, 日本足の外科学会雑誌, 39, 1, 3‐9, 31 Aug. 2018
Japanese

新規ロッキングプレートを用いた内側楔状開大式高位脛骨骨切り術後のスポーツおよび社会復帰に関する検討
薮内康史, 近藤英司, 小野寺純, 小野寺智洋, 八木知徳, 岩崎倫政, 安田和則, 日本整形外科スポーツ医学会雑誌, 38, 4, 388, 31 Aug. 2018
Japanese

マクロファージ共培養モデルにおいて軟骨破片が引き起こすマクロファージの炎症反応および軟骨細胞への影響
濱崎雅成, TERKAWI Mohamad Alaa, 小野寺智洋, 宝満健太郎, 上徳善太, 松原新史, 菱村亮介, 徐亮, 宮崎拓自, 田園, 岩崎倫政, 日本整形外科学会雑誌, 92, 8, S2012, S2012, 30 Aug. 2018
(公社)日本整形外科学会, Japanese

自家骨軟骨柱移植術に高純度アルギン酸ゲルを併用した治療効果の検討
菱村亮介, 小野寺智洋, 上徳善太, 宝満健太郎, 松原新史, 金佑泳, 濱崎雅成, 岩崎倫政, 日本整形外科学会雑誌, 92, 8, S1639, S1639, 30 Aug. 2018
(公社)日本整形外科学会, Japanese

軟骨変性と肥大分化における軟骨細胞グライコームの類似性
宝満健太郎, 小野寺智洋, 花松久寿, 古川潤一, 上徳善太, 松原新史, 菱村亮介, 金佑泳, 濱崎雅成, 宮崎拓自, 岩崎倫政, 日本整形外科学会雑誌, 92, 8, S1653, S1653, 30 Aug. 2018
(公社)日本整形外科学会, Japanese

ビタミンA誘導体の長期投与による早期骨端線閉鎖により両膝内反変形を認めた一例
長谷川裕一, 小野寺智洋, 岩崎浩司, 珍部正嗣, 新井隆太, 近藤英司, 岩崎倫政, 東日本整形災害外科学会雑誌, 30, 3, 314, 21 Aug. 2018
Japanese

軟骨細胞肥大における総合グライコーム解析
宝満健太郎, 花松久寿, 古川潤一, 岡田和恵, 横田育子, PIAO Jinhua, 小野寺智洋, 岩崎倫政, 日本糖質学会年会要旨集, 37th, 123, 20 Aug. 2018
Japanese

小児Run-over injuryによる広範囲足背部組織欠損に対してcrossleg flap施行後骨成長終了までフォローし得た1例　　　　　　　　　　　　　　　
珍部 正嗣, 小野寺 智洋, 新井 隆太, 岩崎 浩司, 岩崎 倫政, 近藤 英司, 綛村 俊之, 北海道整形災害外科学会雑誌, 60, 1, 116, 116, Aug. 2018
北海道整形災害外科学会, Japanese

マウスiPS細胞からの軟骨分化誘導と糖鎖解析を用いた新規バイオマーカーの探索　　　　　　　　　　　　　　　
本谷 和俊, 小野寺 智洋, 寺島 理代, 門間 太輔, 松岡 正剛, 馬場 力哉, 上徳 善太, 松原 新史, 宝満 健太郎, 菱村 亮介, 金 佑泳, 濱崎 雅成, 徐 亮, 岩崎 倫政, 北海道整形災害外科学会雑誌, 60, 1, 145, 145, Aug. 2018
北海道整形災害外科学会, Japanese

軟骨細胞の力学的ストレス応答におけるスフィンゴ糖脂質の機能解析　　　　　　　　　　　　　　　
松原 新史, 小野寺 智洋, 門間 太輔, 馬場 力哉, 本谷 和俊, 上徳 善太, 宝満 健太郎, 岩崎 倫政, 大橋 俊朗, 前田 英次郎, 北海道整形災害外科学会雑誌, 60, 1, 145, 146, Aug. 2018
北海道整形災害外科学会, Japanese

遺残組織を温存した解剖学的2束前十字靱帯再建術の臨床成績 多数例における非温存群と比較　　　　　　　　　　　　　　　
塩田 惇喜, 近藤 英司, 小野寺 智洋, 岩崎 浩司, 珍部 正嗣, 新井 隆太, 岩崎 倫政, 日本整形外科スポーツ医学会雑誌, 38, 4, 434, 434, Aug. 2018
(一社)日本整形外科スポーツ医学会, Japanese

両側膝複合靱帯損傷に対して一期的靱帯再建術を行った一例　　　　　　　　　　　　　　　
鈴木 瞭太, 岩崎 浩司, 下田 康平, 小林 英之, 忠鉢 敏弥, 珍部 正嗣, 新井 隆太, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 60, 1, 158, 158, Aug. 2018
北海道整形災害外科学会, Japanese

TriS Medial HTO Plate Systemを用いた内側楔状開大式高位脛骨骨切り術の短期成績 新規TriS plateでの比較　　　　　　　　　　　　　　　
薮内 康史, 近藤 英司, 亀田 敏明, 佐藤 大, 小野寺 智洋, 岩崎 倫政, 小野寺 純, 八木 知徳, 安田 和則, 北海道整形災害外科学会雑誌, 60, 1, 159, 159, Aug. 2018
北海道整形災害外科学会, Japanese

膝複合靱帯損傷を合併した脛骨高原骨折術後下肢外反変形に対してDouble Level Osteotomyを行った1例　　　　　　　　　　　　　　　
下田 康平, 珍部 正嗣, 小野寺 智洋, 新井 隆太, 岩崎 浩司, 小林 英之, 鈴木 瞭太, 忠鉢 敏弥, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 60, 1, 160, 160, Aug. 2018
北海道整形災害外科学会, Japanese

軟骨細胞にはNF-κB Arthritis Inducer 1を介する炎症回路活性化機構が存在する　　　　　　　　　　　　　　　
太田 光俊, 田中 勇希, 有馬 康伸, 上村 大輔, 小野寺 智洋, 村上 正晃, 岩崎 倫政, 北海道整形災害外科学会雑誌, 60, 1, 164, 164, Aug. 2018
北海道整形災害外科学会, Japanese

当科における人工距骨置換術の短期臨床成績　　　　　　　　　　　　　　　
小林 英之, 小野寺 智洋, 近藤 英司, 岩崎 浩司, 珍部 正嗣, 岩崎 倫政, 深谷 英昭, 北海道整形災害外科学会雑誌, 60, 1, 188, 188, Aug. 2018
北海道整形災害外科学会, Japanese

自家骨軟骨柱移植術に高純度アルギン酸ゲル(UPALゲル)を併用した治療増強効果　　　　　　　　　　　　　　　
菱村 亮介, 小野寺 智洋, 馬場 力哉, 松原 新史, 上徳 善太, 近藤 英司, 岩崎 倫政, JOSKAS, 43, 4, 209, 209, May 2018
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

内側楔状開大式骨切り術後の脛骨の捻転変化 Multiple Planner Reconstruction-CTを用いて　　　　　　　　　　　　　　　
珍部 正嗣, 近藤 英司, 岩崎 浩司, 小野寺 智洋, 小野寺 純, 井上 雅之, 八木 知徳, 安田 和則, 岩崎 倫政, JOSKAS, 43, 4, 293, 293, May 2018
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

ロッキングプレートを用いた逆V字型高位脛骨骨切り術の短期成績　　　　　　　　　　　　　　　
岩崎 浩司, 近藤 英司, 珍部 正嗣, 小野寺 智洋, 小野寺 純, 井上 雅之, 青木 喜満, 八木 知徳, 安田 和則, 岩崎 倫政, JOSKAS, 43, 4, 396, 396, May 2018
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

両膝に発生した内側円板状半月板の2例　　　　　　　　　　　　　　　
青木 佑介, 珍部 正嗣, 近藤 英司, 岩崎 浩司, 新井 隆太, 小野寺 智洋, 安田 和則, 岩崎 倫政, JOSKAS, 43, 4, 624, 624, May 2018
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

新鮮膝重度複合靱帯損傷に対する二期的再建術の短期成績　　　　　　　　　　　　　　　
上徳 善太, 岩崎 浩司, 近藤 英司, 小野寺 智洋, 珍部 正嗣, 安田 和則, 岩崎 倫政, JOSKAS, 43, 4, 676, 676, May 2018
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

骨移植を併用した2期的前十字靱帯再再建術の臨床成績　　　　　　　　　　　　　　　
岩崎 浩司, 近藤 英司, 珍部 正嗣, 小野寺 智洋, 小野寺 純, 八木 知徳, 安田 和則, 岩崎 倫政, JOSKAS, 43, 4, 679, 679, May 2018
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

膝屈筋腱ハイブリッド代用材料を用いた遺残組織温存解剖学的2束前十字靱帯再建術の再鏡視所見 非温存群との年齢別の検討　　　　　　　　　　　　　　　
江畑 拓, 近藤 英司, 岩崎 浩司, 珍部 正嗣, 新井 隆太, 小野寺 智洋, 小野寺 純, 安田 和則, 八木 知徳, 岩崎 倫政, JOSKAS, 43, 4, 685, 685, May 2018
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

人工膝関節全置換術インプラント周囲感染に対する治療成績の検討　　　　　　　　　　　　　　　
新井 隆太, 小野寺 智洋, 岩崎 浩司, 珍部 正嗣, 近藤 英司, 岩崎 倫政, JOSKAS, 43, 4, 747, 747, May 2018
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

内側楔状開大式高位脛骨骨切り術における骨棘移植の効果　　　　　　　　　　　　　　　
徳廣 泰貴, 薮内 康史, 小野寺 純, 小野寺 智洋, 近藤 英司, 八木 知徳, 岩崎 倫政, 安田 和則, JOSKAS, 43, 4, 756, 756, May 2018
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

高位脛骨骨切り術が膝蓋骨高位に与える影響 内側楔状開大式と逆V字型の比較　　　　　　　　　　　　　　　
細川 吉暁, 近藤 英司, 珍部 正嗣, 岩崎 浩司, 小野寺 智洋, 安田 和則, 岩崎 倫政, JOSKAS, 43, 4, 757, 757, May 2018
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

膝屈筋腱ハイブリッド代用材料を用いた解剖学的2束前十字靱帯再建術の臨床成績 術前待機期間の影響　　　　　　　　　　　　　　　
馬場 力哉, 近藤 英司, 小野寺 純, 北村 信人, 小野寺 智洋, 亀田 敏明, 安田 和則, 岩崎 倫政, JOSKAS, 43, 1, 112, 113, Mar. 2018
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

高純度アルギン酸ゲルを併用した骨髄刺激法の効果 ビーグル犬骨軟骨欠損モデルを用いて
馬場 力哉, 小野寺 智洋, 本谷 和俊, 上徳 善太, 松原 新史, 宝満 健太郎, 岩崎 倫政, 北海道整形災害外科学会雑誌, 59, 2, 250, 251, Mar. 2018
北海道整形災害外科学会, Japanese

高マンノース型糖鎖の変化は早期OAに類似した可逆的軟骨変性を生じさせる
宝満 健太郎, 小野寺 智洋, 古川 潤一, 門間 太輔, 松岡 正剛, 馬場 力哉, 本谷 和俊, 上徳 善太, 松原 新史, 菱村 亮介, 金 佑泳, 濱崎 雅成, 徐 亮, 田 園, 岩崎 倫政, 北海道整形災害外科学会雑誌, 59, 2, 253, 253, Mar. 2018
北海道整形災害外科学会, Japanese

軟骨細胞の力学的ストレス応答におけるスフィンゴ糖脂質の機能解析　　　　　　　　　　　　　　　
松原 新史, 小野寺 智洋, 門間 太輔, 馬場 力哉, 本谷 和俊, 上徳 善太, 宝満 健太郎, 岩崎 倫政, 前田 英次郎, 大橋 俊朗, 北海道整形災害外科学会雑誌, 59, 2, 253, 254, Mar. 2018
北海道整形災害外科学会, Japanese

The candidates of glyco-biomarker of chondrocyte hypertrophy detected by Comprehensive N-glycan profiling.　　　　　　　　　　　　　　　
Kentaro Homan, Tomohiro Onodera, Jun-ichi Furukawa, Masatake Matsuoka, Daisuke Momma, Rikiya Baba, Kazutoshi Hontani, Zenta Joutoku, Shinji Matsubara, Ryosuke Hishimura, Kim WooYoung, Masanari Hamasaki, Liang Xu, Yuan Tian, Norimasa Iwasaki, The 64th Annual Meeting of Orthopaedic Research Society (ORS), 43, PS2-104, Mar. 2018
English

Effects Of Mosaicplasty Augmented By Ultrapurified Alginate Ael In A Rabbit Osteochondral Defect Model.　　　　　　　　　　　　　　　
Ryosuke hishimura, Tomohiro Onodera, Kentaro Homan, Shinji Matsubara, Zenta Joutoku, WooYoung Kim, Masanari Hamasaki, Liang Xu, Yuan Tian, Takuji Miyazaki, Norimasa Iwasaki, The 64th Annual Meeting of Orthopaedic Research Society (ORS), 43, PS2-116, Mar. 2018
English

Depletion of Glycoshingolipids Induces the Exvessive Response of Chondrocytes under Mechanical Stress Condition.　　　　　　　　　　　　　　　
Shinji Matsubara, Tomohiro Onodera, Eijiro Maeda, Momma Daisuke, Masatake Matsuoka, Rikiya Baba, Kazutoshi Hontani, Zenta Joutoku, Kentaro Homan, Toshiro Ohashi, Norimasa Iwasaki, The 64th Annual Meeting of Orthopaedic Research Society (ORS), 43, 19, Mar. 2018
English

CCL21/CCR7 Axis Regulating Juvenile Cartilage Repair Can Enhance Cartilage Healing In Adult.　　　　　　　　　　　　　　　
Zenta Joutoku, Tomohiro Onodera, Daisuke Momma, Masatake Matsuoka, Rikiya Baba, Kazutoshi Hontani, Shinji Matsubara, Ryosuke Hishimura, Norimasa Iwasaki, The 64th Annual Meeting of Orthopaedic Research Society (ORS), 43, 12, Mar. 2018
English

新規ロッキングプレートシステムを用いた内側楔状開大式高位脛骨骨切り術の短期成績　　　　　　　　　　　　　　　
薮内 康史, 近藤 英司, 小野寺 純, 小野寺 智洋, 放生 憲博, 八木 知徳, 岩崎 倫政, 安田 和則, 日本整形外科学会雑誌, 92, 2, S132, S132, Mar. 2018
(公社)日本整形外科学会, Japanese

CT osteoabsorptiometry法を用いた内側楔状開大式高位脛骨骨切り術後の膝蓋大腿関節における応力変化　　　　　　　　　　　　　　　
亀田 敏明, 近藤 英司, 薮内 康史, 小野寺 智洋, 小野寺 純, 八木 知徳, 安田 和則, 岩崎 倫政, 日本整形外科学会雑誌, 92, 2, S135, S135, Mar. 2018
(公社)日本整形外科学会, Japanese

前十字靱帯再建術-Update- 前十字靱帯再建術における遺残組織温存の効果　　　　　　　　　　　　　　　
近藤 英司, 岩崎 浩司, 珍部 正嗣, 小野寺 純, 横田 正司, 小野寺 智洋, 安田 和則, 岩崎 倫政, 日本整形外科学会雑誌, 92, 2, S444, S444, Mar. 2018
(公社)日本整形外科学会, Japanese

陳旧性膝重度複合靱帯損傷に対する一期的再建術の治療成績　　　　　　　　　　　　　　　
松原 新史, 近藤 英司, 小野寺 純, 小野寺 智洋, 亀田 敏明, 安田 和則, 岩崎 倫政, JOSKAS, 43, 1, 178, 179, Mar. 2018
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

Tris plateを用いた内側開大式高位脛骨骨切り術の短期成績 抜釘症例における従来のプレートとの比較　　　　　　　　　　　　　　　
薮内 康史, 近藤 英司, 小野寺 純, 亀田 敏明, 佐藤 大, 小野寺 智洋, 八木 知徳, 岩崎 倫政, 安田 和則, JOSKAS, 43, 1, 290, 291, Mar. 2018
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

軟部組織での再発を来した脛骨近位部骨巨細胞腫の一例
新井 隆太, 小野寺 智洋, 河村 太介, 亀田 敏明, 籔内 康史, 下段 俊, 細川 吉暁, 岩崎 倫政, 高桑 恵美, 近藤 英司, 北海道整形災害外科学会雑誌, 59, 2, 269, 269, Mar. 2018
北海道整形災害外科学会, Japanese

血友病性膝関節症に対する人工膝関節置換術の臨床成績　　　　　　　　　　　　　　　
横田 隼一, 小野寺 智洋, 亀田 敏明, 林 晴久, 加藤 琢磨, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 59, 2, 281, 282, Mar. 2018
北海道整形災害外科学会, Japanese

鏡視下足関節固定術における距腿関節間距離および足関節固定角度と骨癒合期間との関係　　　　　　　　　　　　　　　
林 晴久, 小野寺 智洋, 亀田 敏明, 加藤 琢磨, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 59, 2, 288, 288, Mar. 2018
北海道整形災害外科学会, Japanese

当科におけるリウマチ性前足部変形に対する第1MTP関節温存術の治療成績　　　　　　　　　　　　　　　
小野寺 智洋, 林 晴久, 亀田 敏明, 新井 隆太, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 59, 2, 295, 296, Mar. 2018
北海道整形災害外科学会, Japanese

新しいロッキングプレートを用いた内側楔状開大式高位脛骨骨切り術の臨床成績 抜釘症例での検討　　　　　　　　　　　　　　　
薮内 康史, 小野寺 智洋, 亀田 敏明, 佐藤 大, 岩崎 倫政, 近藤 英司, 小野寺 純, 安田 和則, 八木 知徳, 北海道整形災害外科学会雑誌, 59, 2, 334, 334, Mar. 2018
北海道整形災害外科学会, Japanese

高位脛骨骨切り術における深部静脈血栓症の発症率 人工膝関節全置換術との比較　　　　　　　　　　　　　　　
小池 良直, 亀田 敏明, 薮内 康史, 佐藤 大, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 59, 2, 335, 335, Mar. 2018
北海道整形災害外科学会, Japanese

膝屈筋腱ハイブリッド代用材料を用いた解剖学的2束前・後十字靱帯同時再建術の2例　　　　　　　　　　　　　　　
珍部 正嗣, 下出 和美, 石田 博英, 近藤 英司, 亀田 敏明, 小野寺 智洋, 岩崎 倫政, 小野寺 純, 後藤 圭子, 安田 和則, 北海道整形災害外科学会雑誌, 59, 2, 344, 345, Mar. 2018
北海道整形災害外科学会, Japanese

膝屈筋腱ハイブリッド代用材料を用いた遺残組織温存解剖学的2束前十字靱帯再建術の臨床成績 非温存群との年齢別検討　　　　　　　　　　　　　　　
江畑 拓, 近藤 英司, 岩崎 浩司, 珍部 正嗣, 新井 隆太, 小野寺 智洋, 小野寺 純, 安田 和則, 八木 知徳, 岩崎 倫政, 日本整形外科学会雑誌, 92, 3, S617, S617, Mar. 2018
(公社)日本整形外科学会, Japanese

陳旧性膝重度複合靱帯損傷に対する自家腱ハイブリッド代用材料を用いた一期的再建術の治療成績　　　　　　　　　　　　　　　
松原 新史, 近藤 英司, 小野寺 純, 小野寺 智洋, 亀田 敏明, 珍部 正嗣, 北村 信人, 安田 和則, 岩崎 倫政, 日本整形外科学会雑誌, 92, 3, S760, S760, Mar. 2018
(公社)日本整形外科学会, Japanese

リウマチ性外反母趾変形に対するLapidus変法と近位骨切り術の臨床成績の比較　　　　　　　　　　　　　　　
小野寺 智洋, 林 晴久, 近藤 英司, 岩崎 浩司, 珍部 正嗣, 岩崎 倫政, 日本整形外科学会雑誌, 92, 3, S1029, S1029, Mar. 2018
(公社)日本整形外科学会, Japanese

緩徐矯正術後の高度尖足に対する創外固定装着下鏡視下足関節固定術の有用性　　　　　　　　　　　　　　　
小野寺 智洋, 岩崎 浩司, 珍部 正嗣, 林 晴久, 深谷 英昭, 山崎 修司, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 92, 3, S1051, S1051, Mar. 2018
(公社)日本整形外科学会, Japanese

遺残組織を温存した解剖学的2束前十字靱帯再建術の臨床成績 多数例における非温存群と比較　　　　　　　　　　　　　　　
塩田 惇喜, 近藤 英司, 小野寺 智洋, 岩崎 浩司, 珍部 正嗣, 小野寺 純, 安田 和則, 八木 知徳, 岩崎 倫政, 日本整形外科学会雑誌, 92, 3, S1205, S1205, Mar. 2018
(公社)日本整形外科学会, Japanese

膝屈筋腱ハイブリッド代用材料を用いた一期的および二期的2束前十字靱帯再再建術の臨床成績　　　　　　　　　　　　　　　
岩崎 浩司, 近藤 英司, 珍部 正嗣, 小野寺 智洋, 小野寺 純, 八木 知徳, 安田 和則, 岩崎 倫政, 日本整形外科学会雑誌, 92, 3, S1206, S1206, Mar. 2018
(公社)日本整形外科学会, Japanese

人工膝関節全置換術後インプラント周囲感染に対する治療成績の検討　　　　　　　　　　　　　　　
新井 隆太, 小野寺 智洋, 岩崎 浩司, 珍部 正嗣, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 92, 3, S1287, S1287, Mar. 2018
(公社)日本整形外科学会, Japanese

8-plateを用いた成長抑制術を行い脚長補正に2年を要した下肢片側肥大症の1例
甲斐原 拓真, 小野寺 智洋, 薮内 康史, 亀田 敏明, 近藤 英司, 岩崎 倫政, 北海道整形災害外科学会雑誌 : 北海道整形災害外科学会機関誌, 59, 2, 225, 228, Mar. 2018
北海道整形災害外科学会, Japanese

軟骨再生研究 (誌上シンポジウム 北海道における整形外科基礎研究)
小野寺 智洋, 岩崎 倫政, 北海道整形災害外科学会雑誌 : 北海道整形災害外科学会機関誌, 59, 2, 209, 212, Mar. 2018
北海道整形災害外科学会, Japanese

基礎研究体制と概要 : 北海道大学整形外科 (誌上シンポジウム 北海道における整形外科基礎研究)
角家 健, 近藤 英司, 高畑 雅彦, 須藤 英毅, 古川 潤一, 小野寺 智洋, テルカウイ アラー, 岩崎 倫政, 北海道整形災害外科学会雑誌 : 北海道整形災害外科学会機関誌, 59, 2, 197, 204, Mar. 2018
北海道整形災害外科学会, Japanese

マクロファージ共培養モデルにおいて軟骨破片が軟骨細胞に与える影響
濱崎雅成, TERKAWI Mohamad Alaa, 小野寺智洋, 宝満健太郎, 上徳善太, 松原新史, 菱村亮介, KIM WooYoung, XU Liang, 岩崎倫政, 日本軟骨代謝学会プログラム・抄録集, 31st, 75, Feb. 2018
Japanese

軟骨細胞肥大分化における統合グライコミクス
宝満健太郎, 小野寺智洋, 花松久寿, 古川潤一, 上徳善太, 松原新史, 菱村亮介, KIM WooYoung, 濱崎雅成, XU Liang, 宮崎拓自, TIAN Yuan, 岩崎倫政, 日本軟骨代謝学会プログラム・抄録集, 31st, 94, Feb. 2018
Japanese

リウマチ性膝関節症に対するTKAではBMI,MMP‐3低値が術後感染のリスク因子となりうる
青木佑介, 小野寺智洋, 岩崎浩司, 珍部正嗣, 新井隆太, 近藤英司, 岩崎倫政, 北海道整形災害外科学会, 134th, 55, 2018
Japanese

マクロファージ共培養モデルにおいて軟骨破片が軟骨細胞に与える影響
濱崎雅成, テルカウイ アラー, 小野寺智洋, 宝満健太郎, 上徳善太, 松原新史, 菱村亮介, 徐亮, 田園, 岩崎倫政, 北海道整形災害外科学会, 134th, 134th suppl, 37, 37, 2018
北海道整形災害外科学会, Japanese

軟骨細胞肥大分化の包括的N型糖鎖プロファイリングによる糖鎖バイオマーカー探索
宝満健太郎, 小野寺智洋, 花松久寿, 古川潤一, 門間太輔, 松岡正剛, 馬場力哉, 本谷和俊, 上徳善太, 松原新史, 菱村亮介, 金佑泳, 濱崎雅成, 岩崎倫政, 北海道整形災害外科学会, 134th, 134th suppl, 36, 36, 2018
北海道整形災害外科学会, Japanese

骨軟骨柱移植術に高純度アルギン酸ゲル(UPALゲル)移植を併用した治療効果の検討
菱村亮介, 小野寺智洋, 宝満健太郎, KIM Woo Yong, 濱崎雅成, XU Liang, 岩崎倫政, 日本バイオマテリアル学会大会予稿集(Web), 40th, 166 (WEB ONLY), 166, 2018
日本バイオマテリアル学会, Japanese

リウマチ性足関節症に対するIlizarov創外固定器を用いた足関節固定術と鏡視下足関節固定術の比較検討　　　　　　　　　　　　　　　
林 晴久, 小野寺 智洋, 深谷 英昭, 岩崎 倫政, 近藤 英司, 山崎 修司, 日本創外固定・骨延長学会雑誌, 29, 148, 148, Jan. 2018
日本創外固定・骨延長学会, Japanese

重度麻痺性尖足変形に対する創外固定装着下鏡視下足関節固定術の小経験　　　　　　　　　　　　　　　
小野寺 智洋, 林 晴久, 深谷 英昭, 岩崎 倫政, 近藤 英司, 山崎 修司, 日本創外固定・骨延長学会雑誌, 29, 157, 157, Jan. 2018
日本創外固定・骨延長学会, Japanese

小児線状強皮症に対してシクロスポリン内服が有効であった3例　　　　　　　　　　　　　　　
眞井 翔子, 藤田 靖幸, 宮内 俊成, 藤村 悠, 夏賀 健, 乃村 俊史, 西江 渉, 清水 宏, 小野寺 智洋, 岡 敏明, 日本皮膚科学会雑誌, 128, 1, 62, 62, Jan. 2018
(公社)日本皮膚科学会, Japanese

TriS Medial HTO Plate Systemを用いた内側楔状開大式高位脛骨骨切り術の短期成績　　　　　　　　　　　　　　　
薮内 康史, 近藤 英司, 小野寺 智洋, 亀田 敏明, 佐藤 大, 岩崎 倫政, 小野寺 純, 安田 和則, 八木 知徳, 日本関節病学会誌, 36, 4, 427, 433, Dec. 2017
(一社)日本関節病学会, Japanese

ケモカインCCL21を用いた軟骨再生のためのインテリジェントマテリアルの開発
上徳 善太, 小野寺 智洋, 松岡 正剛, 馬場 力哉, 本谷 和俊, 宝満 健太郎, 岩崎 倫政, 日本バイオマテリアル学会大会予稿集, 39回, 96, 96, 13 Nov. 2017
日本バイオマテリアル学会, Japanese

ケモカインCCL21を用いた軟骨再生のためのインテリジェントマテリアルの開発　　　　　　　　　　　　　　　
上徳 善太, 小野寺 智洋, 松岡 正剛, 馬場 力哉, 本谷 和俊, 宝満 健太郎, 岩崎 倫政, 日本バイオマテリアル学会大会予稿集, 39回, 96, 96, Nov. 2017
日本バイオマテリアル学会, Japanese

最新基礎科学 知っておきたい 高純度アルギン酸ゲルを用いた関節軟骨に対する新規治療法の開発
小野寺 智洋, 馬場 力哉, 五十嵐 達弥, 佃 幸憲, 祐川 敦, 岩崎 倫政, 臨床整形外科, 52, 11, 1050, 1054, Nov. 2017
(株)医学書院, Japanese

足趾に局所再発を来した腫瘍性骨軟化症の1例
新井隆太, 小野寺智洋, 近藤英司, 岩崎倫政, 日本足の外科学会雑誌, 38, 2, S315, 11 Oct. 2017
Japanese

血友病性膝関節症に対する人工膝関節置換術の臨床成績　　　　　　　　　　　　　　　
横田 隼一, 小野寺 智洋, 亀田 敏明, 林 晴久, 加藤 琢磨, 近藤 英司, 岩崎 倫政, 日本関節病学会誌, 36, 3, 322, 322, Oct. 2017
(一社)日本関節病学会, Japanese

TriS plateを用いた内側楔状開大式高位脛骨骨切り術の短期成績 抜釘症例における従来のプレートとの比較　　　　　　　　　　　　　　　
薮内 康史, 近藤 英司, 小野寺 純, 竹内 博紀, 小野寺 智洋, 八木 知徳, 岩崎 倫政, 安田 和則, 日本関節病学会誌, 36, 3, 335, 335, Oct. 2017
(一社)日本関節病学会, Japanese

65歳以上の高齢者に対する内側楔状開大式高位脛骨骨切り術の臨床成績　　　　　　　　　　　　　　　
竹内 博紀, 藪内 康史, 近藤 英司, 小野寺 純, 小野寺 智洋, 八木 知徳, 岩崎 倫政, 安田 和則, 日本関節病学会誌, 36, 3, 336, 336, Oct. 2017
(一社)日本関節病学会, Japanese

両側膝複合靱帯損傷に対して一期的靱帯再建術を行った一例　　　　　　　　　　　　　　　
鈴木 瞭太, 近藤 英司, 忠鉢 敏弥, 下田 康平, 小林 英之, 岩崎 浩司, 珍部 正嗣, 新井 隆太, 小野寺 智洋, 岩崎 倫政, 日本関節病学会誌, 36, 3, 379, 379, Oct. 2017
(一社)日本関節病学会, Japanese

麻痺性尖足変形に対する創外固定装着下鏡視下足関節固定術の臨床成績　　　　　　　　　　　　　　　
小野寺 智洋, 林 晴久, 深谷 英昭, 山崎 修司, 近藤 英司, 岩崎 倫政, 日本足の外科学会雑誌, 38, 2, S229, S229, Oct. 2017
日本足の外科学会, Japanese

従来型MRIに対応した独自のソフトウエアを用いた膝軟骨体積の評価(Assessment of Knee Cartilage Volume Using an Original Software for Conventional MRI)　　　　　　　　　　　　　　　
宍戸 駿, 神島 保, 加藤 一樹, 市川 翔太, 近藤 英司, 小野寺 智洋, 日本放射線技術学会雑誌, 73, 9, 867, 867, Sep. 2017
(公社)日本放射線技術学会, English

Assessment of Knee Cartilage Volume Using an Original Software for Conventional MRI(和訳中)
宍戸 駿, 神島 保, 加藤 一樹, 市川 翔太, 近藤 英司, 小野寺 智洋, 日本放射線技術学会雑誌, 73, 9, 867, 867, Sep. 2017
(公社)日本放射線技術学会, English

関節軟骨の再生医療 CCL21/CCR7は幼若個体での軟骨修復に重要である
上徳 善太, 小野寺 智洋, 門間 太輔, 松岡 正剛, 馬場 力哉, 本谷 和俊, 松原 新史, 宝満 健太郎, 菱村 亮介, 金 佑泳, 濱崎 雅成, 徐 亮, 岩崎 倫政, 日本整形外科学会雑誌, 91, 8, S1467, S1467, Aug. 2017
(公社)日本整形外科学会, Japanese

関節軟骨の再生医療 マウスiPS細胞の軟骨分化誘導と糖鎖解析を用いた新規バイオマーカーの探索
本谷 和俊, 小野寺 智洋, 寺島 理代, 門間 太輔, 松岡 正剛, 上徳 善太, 松原 新史, 宝満 健太郎, 菱村 亮介, 濱崎 雅成, 金 佑泳, 徐 亮, 田 園, 岩崎 倫政, 日本整形外科学会雑誌, 91, 8, S1469, S1469, Aug. 2017
(公社)日本整形外科学会, Japanese

The Effect of Releasing the Superficial Medial Collateral Ligament in Open-Wedge High Tibial Osteotomy : In vivo Study Evaluating Medial Joint Opening by Stress Radiography
佐藤 大, 薮内 康史, 小野寺 智洋, 亀田 敏明, 岩崎 倫政, 近藤 英司, 小野寺 純, 北村 信人, 八木 知徳, 坂本 圭太, 高澤 啓, 安田 和則, 日本関節病学会誌, 59, 1, 162, 163, Aug. 2017
北海道整形災害外科学会, Japanese

陳旧性膝複合靱帯損傷に対する後外側支持機構再建術(Clancy変法)の治療成績　　　　　　　　　　　　　　　
松原 新史, 近藤 英司, 小野寺 純, 小野寺 智洋, 亀田 敏明, 北村 信人, 安田 和則, 岩崎 倫政, 日本整形外科スポーツ医学会雑誌, 37, 4, 374, 374, Aug. 2017
(一社)日本整形外科スポーツ医学会, Japanese

膝屈筋腱ハイブリッド材料を用いた解剖学的2束後十字靱帯再建術の臨床成績　　　　　　　　　　　　　　　
亀田 敏明, 近藤 英司, 小野寺 智洋, 後藤 圭子, 小野寺 純, 北村 信人, 川村 大介, 安田 和則, 岩崎 倫政, 日本整形外科スポーツ医学会雑誌, 37, 4, 396, 396, Aug. 2017
(一社)日本整形外科スポーツ医学会, Japanese

内側楔状開大式高位脛骨骨切り術後のスポーツおよび社会復帰に関する検討　　　　　　　　　　　　　　　
薮内 康史, 近藤 英司, 小野寺 純, 亀田 敏明, 佐藤 大, 小野寺 智洋, 放生 憲博, 八木 知徳, 安田 和則, 岩崎 倫政, 日本整形外科スポーツ医学会雑誌, 37, 4, 533, 533, Aug. 2017
(一社)日本整形外科スポーツ医学会, Japanese

膝屈筋腱ハイブリッド代用材料を用いた解剖学的2束前・後十字靱帯同時再建術の2例　　　　　　　　　　　　　　　
珍部 正嗣, 近藤 英司, 小野寺 純, 石田 博英, 小野寺 智洋, 岩崎 浩司, 下出 和美, 安田 和則, 岩崎 倫政, 日本整形外科スポーツ医学会雑誌, 37, 4, 607, 607, Aug. 2017
(一社)日本整形外科スポーツ医学会, Japanese

鏡視下膝靱帯再建術後における急性関節内感染 同一施設における10年間の検討　　　　　　　　　　　　　　　
亀田 敏明, 小野寺 智洋, 藪内 康史, 岩崎 倫政, 近藤 英司, 小野寺 純, 北村 信人, 安田 和則, 北海道整形災害外科学会雑誌, 59, 1, 118, 119, Aug. 2017
北海道整形災害外科学会, Japanese

TriS Medial HTO Plate Systemを用いた内側楔状開大式高位脛骨骨切り術　　　　　　　　　　　　　　　
薮内 康史, 小野寺 智洋, 亀田 敏明, 佐藤 大, 岩崎 倫政, 近藤 英司, 小野寺 純, 北村 信人, 安田 和則, 八木 知徳, 北海道整形災害外科学会雑誌, 59, 1, 162, 162, Aug. 2017
北海道整形災害外科学会, Japanese

膝関節に発生したびまん型色素性絨毛結節性滑膜炎の治療成績　　　　　　　　　　　　　　　
新井 隆太, 小野寺 智洋, 薮内 康史, 亀田 敏明, 高橋 大介, 入江 徹, 浅野 毅, 下段 俊, 岩崎 倫政, 近藤 英司, 安田 和則, 北海道整形災害外科学会雑誌, 59, 1, 168, 169, Aug. 2017
北海道整形災害外科学会, Japanese

Taylor Spatial Frameを用いて治療した脛腓骨遠位部骨折後変形治癒の一例　　　　　　　　　　　　　　　
小池 良直, 小野寺 智洋, 藪内 康史, 亀田 敏明, 新井 隆太, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 59, 1, 173, 173, Aug. 2017
北海道整形災害外科学会, Japanese

関節軟骨の再生医療 高純度硬化性アルギン酸ゲル移植は家兎半月板部分欠損モデルにおいて半月板修復を促進する
金 佑泳, 近藤 英司, 小野寺 智洋, 野々山 貴行, 馬場 力哉, 本谷 和俊, 上徳 善太, 松原 新史, 宝満 健太郎, 菱村 亮介, Terkawi Muhamad, 岩崎 倫政, 日本整形外科学会雑誌, 91, 8, S1468, S1468, Aug. 2017
(公社)日本整形外科学会, Japanese

内側楔状開大式高位脛骨骨切り術後の膝蓋大腿関節における応力変化 CT osteoabsorptiometry法を用いて　　　　　　　　　　　　　　　
亀田 敏明, 近藤 英司, 薮内 康史, 小野寺 智洋, 小野寺 純, 八木 知徳, 安田 和則, 岩崎 倫政, 日本整形外科学会雑誌, 91, 8, S1694, S1694, Aug. 2017
(公社)日本整形外科学会, Japanese

高位脛骨骨切り術における深部静脈血栓症の検討
小池 良直, 亀田 敏明, 近藤 英司, 藪内 康史, 下段 俊, 浅野 毅, 新井 隆太, 入江 徹, 髙橋 大介, 小野寺 智洋, 安田 和則, 岩崎 倫政, 北海道整形災害外科学会雑誌 : 北海道整形災害外科学会機関誌, 59, 1, 78, 84, Aug. 2017
北海道整形災害外科学会, Japanese

学術奨励賞・受賞記念論文 Syndecan-4 regulates development of autoimmune arthritis by modulating B cell migration and germinal center formation : 自己免疫性関節炎におけるシンデカン-4の機能解析
遠藤 努, 伊藤 甲雄, 森本 純子, 金山 剛士, 太田 大地, 池末 昌弘, 今 重之, 小野寺 智洋, 高橋 大介, 岩崎 倫政, 上出 利光, 北海道整形災害外科学会雑誌 : 北海道整形災害外科学会機関誌, 59, 1, 11, 17, Aug. 2017
北海道整形災害外科学会, Japanese

膝軟骨欠損に対する自家培養軟骨細胞移植(JACC)の短期成績　　　　　　　　　　　　　　　
甲斐原 拓真, 薮内 康史, 小野寺 智洋, 亀田 敏明, 岩崎 倫政, 近藤 英司, 遠山 晴一, 安田 和則, 北海道整形災害外科学会雑誌, 59, 1, 166, 166, Aug. 2017
北海道整形災害外科学会, Japanese

超高分子ポリエチレン摩耗粉によるヒトマクロファージの遺伝子発現変化は関節リウマチと類似する　　　　　　　　　　　　　　　
Terkawi Alaa, 濱崎 雅成, 高橋 大介, 角家 健, 浅野 毅, 入江 徹, 小野寺 智洋, 高畑 雅彦, 岩崎 倫政, 日本整形外科学会雑誌, 91, 8, S1722, S1722, Aug. 2017
(公社)日本整形外科学会, Japanese

自家骨軟骨柱移植術に高純度アルギン酸ゲルを併用した治療効果の検証　　　　　　　　　　　　　　　
菱村 亮介, 小野寺 智洋, 馬場 力哉, 本谷 和俊, 宝満 健太郎, 松原 新史, 上徳 善太, 金 佑泳, 岩崎 倫政, 日本整形外科学会雑誌, 91, 8, S1727, S1727, Aug. 2017
(公社)日本整形外科学会, Japanese

軟骨細胞にはNF-κB arthritis inducer 1を介する炎症回路活性化機構が存在する　　　　　　　　　　　　　　　
太田 光俊, 田中 勇希, 蒋 菁菁, 中川 育磨, 樋口 はるか, 藤田 宗純, 有馬 康伸, 熱海 徹, 上村 大輔, 小野寺 智洋, 村上 正晃, 岩崎 倫政, 日本整形外科学会雑誌, 91, 8, S1728, S1728, Aug. 2017
(公社)日本整形外科学会, Japanese

新規ロッキングプレートを用いた内側楔状開大式高位脛骨骨切り術の生体力学的および臨床的評価 従来のプレートとの比較　　　　　　　　　　　　　　　
薮内 康史, 近藤 英司, 小野寺 純, 亀田 敏明, 佐藤 大, 小野寺 智洋, 放生 憲博, 八木 知徳, 岩崎 倫政, 安田 和則, 日本整形外科学会雑誌, 91, 8, S1765, S1765, Aug. 2017
(公社)日本整形外科学会, Japanese

軟骨細胞の力学的ストレス応答におけるスフィンゴ糖脂質の機能解析　　　　　　　　　　　　　　　
松原 新史, 小野寺 智洋, 前田 英次郎, 門間 太輔, 馬場 力哉, 本谷 俊彦, 上徳 善太, 宝満 健太郎, 大橋 俊朗, 岩崎 倫政, 日本整形外科学会雑誌, 91, 8, S1774, S1774, Aug. 2017
(公社)日本整形外科学会, Japanese

膝複合靱帯損傷を合併した脛骨高原骨折術後下肢外反変形に対してDouble Level Osteotomyを行った1例　　　　　　　　　　　　　　　
下田 康平, 珍部 正嗣, 近藤 英司, 小野寺 智洋, 新井 隆太, 岩崎 浩司, 小林 英之, 鈴木 瞭太, 忠鉢 敏弥, 岩崎 倫政, 東日本整形災害外科学会雑誌, 29, 3, 286, 286, Aug. 2017
東日本整形災害外科学会, Japanese

Tris Medial HTO Plate Systemを用いた内側楔状開大式高位脛骨骨切り術の短期成績
薮内 康史, 近藤 英司, 小野寺 純, 亀田 敏明, 小野寺 智洋, 佐藤 大, 八木 知徳, 安田 和則, 岩崎 倫政, 東日本整形災害外科学会雑誌, 29, 3, 392, 392, Aug. 2017
東日本整形災害外科学会, Japanese

内側楔状開大式高位脛骨骨切り術における内側側副靱帯浅層剥離の影響 定量的膝外反ストレス撮影による検討
佐藤 大, 薮内 康史, 小野寺 智洋, 亀田 敏明, 岩崎 倫政, 近藤 英司, 小野寺 純, 北村 信人, 八木 知徳, 坂本 圭太, 高澤 啓, 安田 和則, 日本関節病学会誌, 36, 2, 131, 139, Jul. 2017
(一社)日本関節病学会, Japanese

Tris Medial HTO Plate Systemを用いた内側楔状開大式高位脛骨骨切り術の短期成績 抜釘症例における従来のプレートとの比較　　　　　　　　　　　　　　　
薮内 康史, 近藤 英司, 小野寺 純, 亀田 敏明, 佐藤 大, 小野寺 智洋, 八木 知徳, 岩崎 倫政, 安田 和則, JOSKAS, 42, 4, 527, 527, May 2017
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

陳旧性膝重度複合靱帯損傷に対する一期的再建術の治療成績　　　　　　　　　　　　　　　
松原 新史, 近藤 英司, 小野寺 純, 小野寺 智洋, 亀田 敏明, 北村 信人, 安田 和則, 岩崎 倫政, JOSKAS, 42, 4, 617, 617, May 2017
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

膝軟骨欠損に対するアテロコラーゲンを用いた自家培養軟骨移植の短〜中期成績　　　　　　　　　　　　　　　
甲斐原 拓真, 近藤 英司, 亀田 敏明, 小野寺 智洋, 薮内 康史, 遠山 晴一, 安田 和則, 岩崎 倫政, JOSKAS, 42, 4, 285, 285, May 2017
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

高度内反変形および膝蓋骨亜脱臼を伴う変形性膝関節症に対して逆V字型高位脛骨骨切り術およびBlauth‐Mann変法を行った一例
松居祐樹, 亀田敏明, 小野寺智洋, 寺尾英将, 加藤琢磨, 林晴久, 岩崎倫政, 近藤英司, 小野寺純, 北村信人, 安田和則, 北海道整形災害外科学会雑誌, 58, 2, 336‐337, 24 Mar. 2017
Japanese

高マンノース型糖鎖の減少は可逆的軟骨変性を引き起こす
宝満健太郎, 小野寺智洋, 古川潤一, 門間太輔, 松岡正剛, 馬場力哉, 本谷和俊, 上徳善太, 松原新史, 菱村亮介, KIM Wooyoung, 濱崎雅成, XU Liang, TIAN Yuan, 岩崎倫政, 日本軟骨代謝学会プログラム・抄録集, 30th, 112, Mar. 2017
Japanese

軟骨細胞の力学的ストレス応答におけるスフィンゴ糖脂質の機能解析　　　　　　　　　　　　　　　
松原新史, 小野寺智洋, 前田英次郎, 門間太輔, 馬場力哉, 本谷和俊, 上徳善太, 宝満健太郎, 大橋俊朗, 岩崎倫政, 第30回日本軟骨代謝学会, 120, Mar. 2017

高純度アルギン酸ゲルを併用した骨髄刺激法の効果―ビーグル犬骨軟骨欠損モデルを用いて―　　　　　　　　　　　　　　　
馬場力哉, 小野寺智洋, 松岡正剛, 本谷和俊, 上徳善太, 松原新史, 宝満健太郎, 岩崎倫政, 第30回日本軟骨代謝学会, 66, Mar. 2017

軟骨自然治癒過程に発現するCCL21による軟骨修復の検討
上徳善太, 小野寺智洋, 古川潤一, 門間太輔, 松岡正剛, 馬場力哉, 本谷和俊, 松原新史, 宝満健太郎, 菱村亮介, 岩崎倫政, 第30回日本軟骨代謝学会, 30th, 94, Mar. 2017

高マンノース型糖鎖の減少は可逆的軟骨変性を引き起こす
宝満健太郎, 小野寺智洋, 古川潤一, 門間太輔, 松岡正剛, 馬場力哉, 本谷和俊, 上徳善太, 松原新史, 菱村亮介, 金佑泳, 濱崎雅成, 徐亮,田園, 岩崎倫政, 第30回日本軟骨代謝学会, 30th, 120, Mar. 2017

糖鎖解析を用いたiPS細胞からの軟骨分化における新規バイオマーカーの探索
本谷和俊, 小野寺智洋, 寺島理代, 門間太輔, 松岡正剛, 馬場力哉, 上徳善太, 松原新史, 宝満健太郎, 菱村亮介, 金佑泳, 濱崎雅成, 徐亮,田園, 岩崎倫政, 第30回日本軟骨代謝学会, 30th, 101, Mar. 2017

Identification Of Differentiation Biomarkers For The Chondrogenic Differentiation Of Induced Pluripotent Stem Cells.　　　　　　　　　　　　　　　
Kazutoshi Hontani, Tomohiro Onodera, Daisuke Momma, Masatake Matsuoka, Rikiya Baba, Zenta Joutoku, Shinji Matsubara, Kentaro Homan, Kentaro Homan, Ryosuke Hishimura, Kim WooYoung, Masanari Hamasaki, Liang Xu, Yuan Tian, Norimasa Iwasaki, The 63th Annual Meeting of Orthopaedic Research Society (ORS), Mar. 2017
English

Depletion Of Gangliosides Enhances Articular Cartilage Repair By Suppressing The Chondrocyte Hypertrophy.　　　　　　　　　　　　　　　
Masatake Matsuoka, Tomohiro Onodera, Kentaro Homan, Fumio Sasazawa, Daisuke Momma, Rikiya Baba, Kazutoshi Hontani, Zenta Joutoku, Shinji Matsubara, Ryosuke Hishimura, Norimasa Iwasaki, The 63th Annual Meeting of Orthopaedic Research Society (ORS), Mar. 2017
English

Effects Of Autologous Osteochondral Transplantation Augmented By Ultrapurified Alginate Gel In Rabbit Model.　　　　　　　　　　　　　　　
Ryosuke Hishimura, Tomohiro Onodera, Kazutoshi Hontani, Rikiya Baba, Kentaro Homan, Shinji Matsubara, Zenta Joutoku, WooYoung Kim, Norimasa Iwasaki, The 63th Annual Meeting of Orthopaedic Research Society (ORS), Mar. 2017
English

CCL21 Expressed in Cartilage Repair Process in Immature Mice and Accelerated Cartilage Repair.　　　　　　　　　　　　　　　
Zenta Joutoku, Tomohiro Onodera, Daisuke Momma, Masatake Matsuoka, Rikiya Baba, Kazutoshi Hontani, Shinji Matsubara, Kentaro Homan, Ryosuke Hishimura, Norimasa Iwasaki, The 63th Annual Meeting of Orthopaedic Research Society (ORS), Mar. 2017
English

The enzymatic cleavage of high-mannose type N-glycan induces recoverable cartilage degradation.　　　　　　　　　　　　　　　
Kentaro Homan, Tomohiro Onodera, Jun-ichi Furukawa, Daisuke Momma, Masatake Matsuoka, Rikiya Baba, Kazutoshi Hontani, Zenta Joutoku, Shinji Matsubara, Ryosuke Hishimura, Kim WooYoung, Masanari Hamasaki, Liang Xu, Norimasa Iwasaki, The 63th Annual Meeting of Orthopaedic Research Society (ORS), Mar. 2017
English

三次元培養下における伸張ストレス負荷モデルの確立
松原 新史, 小野寺 智洋, 門間 太輔, 松岡 正剛, 馬場 力哉, 本谷 和俊, 上徳 善太, 宝満 健太郎, キム・ウヨン, 岩崎 倫政, 北海道整形災害外科学会雑誌, 58, 2, 270, 271, Mar. 2017
北海道整形災害外科学会, Japanese

ガングリオシド欠損はIndian Hedgehog pathwayを介し軟骨の肥大化を抑制する
松岡 正剛, 小野寺 智洋, 笹沢 史生, 門間 太輔, 馬場 力哉, 本谷 和俊, 上徳 善太, 宝満 健太郎, 岩崎 倫政, 北海道整形災害外科学会雑誌, 58, 2, 269, 270, Mar. 2017
北海道整形災害外科学会, Japanese

新しいLocking plate(Tris Medial HTO Plate System)を用いた内側楔状開大式高位脛骨骨切り術　　　　　　　　　　　　　　　
薮内 康史, 小野寺 智洋, 亀田 敏明, 岩崎 倫政, 類家 拓也, 伊藤 浩, 近藤 英司, 小野寺 純, 北村 信人, 安田 和則, 八木 知徳, 北海道整形災害外科学会雑誌, 58, 2, 268, 268, Mar. 2017
北海道整形災害外科学会, Japanese

内側楔状開大式高位脛骨骨切り術後の膝蓋大腿関節における応力変化 CT osteoabsorptiometry法を用いて　　　　　　　　　　　　　　　
亀田 敏明, 小野寺 智洋, 薮内 康史, 岩崎 倫政, 近藤 英司, 小野寺 純, 北村 信人, 安田 和則, 八木 知徳, 北海道整形災害外科学会雑誌, 58, 2, 268, 269, Mar. 2017
北海道整形災害外科学会, Japanese

ハイブリッド型人工股関節の術後中・長期成績　　　　　　　　　　　　　　　
入江 徹, 高橋 大介, 浅野 毅, 下段 俊, 亀田 敏明, 新井 隆太, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 58, 2, 277, 278, Mar. 2017
北海道整形災害外科学会, Japanese

THA術後の骨代謝状態の変化の検討　　　　　　　　　　　　　　　
浅野 毅, 高橋 大介, 入江 徹, 下段 俊, 新井 隆太, 亀田 敏明, 薮内 康史, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 58, 2, 279, 280, Mar. 2017
北海道整形災害外科学会, Japanese

大腿骨頭軟骨下脆弱性骨折の予後予測因子の検討 免荷保存治療は効果があるのか　　　　　　　　　　　　　　　
高橋 大介, 入江 徹, 浅野 毅, 下段 俊, 新井 隆太, 薮内 康史, 亀田 敏明, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 58, 2, 280, 280, Mar. 2017
北海道整形災害外科学会, Japanese

経過中にMRI所見が変化した大腿骨頭軟骨下脆弱性骨折の1例　　　　　　　　　　　　　　　
細川 吉暁, 浅野 毅, 高橋 大介, 入江 徹, 新井 隆太, 下段 俊, 亀田 敏明, 薮内 康史, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 58, 2, 280, 281, Mar. 2017
北海道整形災害外科学会, Japanese

大腿骨転子間彎曲内反骨切り術が股関節外転角度に与える影響　　　　　　　　　　　　　　　
下段 俊, 入江 徹, 高橋 大介, 浅野 毅, 新井 隆太, 亀田 敏明, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 58, 2, 290, 290, Mar. 2017
北海道整形災害外科学会, Japanese

非定型大腿骨骨折19例の検討 骨折部位別の比較検討　　　　　　　　　　　　　　　
吉田 朋世, 高橋 大介, 入江 徹, 浅野 毅, 小野寺 智洋, 岩崎 倫政, 梅本 貴央, 田辺 明彦, 宮崎 拓自, 山本 励志, 近藤 英司, 北海道整形災害外科学会雑誌, 58, 2, 293, 293, Mar. 2017
北海道整形災害外科学会, Japanese

高位脛骨骨切り術における深部静脈血栓症の検討　　　　　　　　　　　　　　　
小池 良直, 亀田 敏明, 藪内 康史, 下段 俊, 浅野 毅, 新井 隆太, 入江 徹, 高橋 大介, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 安田 和則, 北海道整形災害外科学会雑誌, 58, 2, 307, 308, Mar. 2017
北海道整形災害外科学会, Japanese

距骨離断性骨軟骨炎に対して経内果的鏡視下アプローチにて骨軟骨柱移植を施行した一例　　　　　　　　　　　　　　　
小野寺 智洋, 近藤 英司, 岩崎 倫政, 内田 淳, 北海道整形災害外科学会雑誌, 58, 2, 312, 313, Mar. 2017
北海道整形災害外科学会, Japanese

外反母趾変形矯正術前後における第1遠位指節間関節外反変形の検討　　　　　　　　　　　　　　　
上徳 善太, 小野寺 智洋, 松岡 正剛, 近藤 英司, 亀田 敏明, 薮内 康史, 岩崎 倫政, 山崎 修司, 北海道整形災害外科学会雑誌, 58, 2, 314, 314, Mar. 2017
北海道整形災害外科学会, Japanese

内側楔状開大式高位脛骨骨切り術における内側側副靱帯浅層剥離の影響 定量的膝外反ストレス撮影による検討　　　　　　　　　　　　　　　
佐藤 大, 近藤 英司, 薮内 康史, 小野寺 純, 小野寺 智洋, 亀田 敏明, 八木 知徳, 岩崎 倫政, 安田 和則, 日本整形外科学会雑誌, 91, 2, S32, S32, Mar. 2017
(公社)日本整形外科学会, Japanese

内側楔状開大式高位脛骨骨切り術後の膝蓋大腿関節における応力変化 CT osteoabsorptiometry法を用いて　　　　　　　　　　　　　　　
亀田 敏明, 近藤 英司, 薮内 康史, 小野寺 智洋, 小野寺 純, 安田 和則, 岩崎 倫政, 日本整形外科学会雑誌, 91, 2, S33, S33, Mar. 2017
(公社)日本整形外科学会, Japanese

鏡視下足関節固定術における距腿関節間距離および足関節固定角度と骨癒合期間との関係　　　　　　　　　　　　　　　
林 晴久, 小野寺 智洋, 近藤 英司, 亀田 敏明, 加藤 琢磨, 岩崎 倫政, 日本整形外科学会雑誌, 91, 2, S87, S87, Mar. 2017
(公社)日本整形外科学会, Japanese

鏡視下膝靱帯再建術後における急性関節内感染 同一施設における15年間の検討　　　　　　　　　　　　　　　
亀田 敏明, 近藤 英司, 薮内 康史, 小野寺 智洋, 小野寺 純, 北村 信人, 安田 和則, 岩崎 倫政, 日本整形外科学会雑誌, 91, 2, S245, S245, Mar. 2017
(公社)日本整形外科学会, Japanese

膝軟骨欠損に対するアテロコラーゲンを用いた自家培養軟骨移植の短〜中期成績　　　　　　　　　　　　　　　
甲斐原 拓真, 亀田 敏明, 近藤 英司, 小野寺 智洋, 薮内 康史, 遠山 晴一, 安田 和則, 岩崎 倫政, 日本整形外科学会雑誌, 91, 3, S1142, S1142, Mar. 2017
(公社)日本整形外科学会, Japanese

自家骨軟骨柱移植術に高純度アルギン酸ゲルをaugumentationした治療効果の検討
菱村亮介, 小野寺智洋, 馬場力也, 本谷和俊, 宝満健太郎, 松原新史, 上徳善太, 金佑泳, 岩崎倫政, 北海道整形災害外科学会, 132nd, 5, 2017
Japanese

高度内反変形と膝蓋骨亜脱臼を伴う両変形性膝関節症に対して逆V字型高位脛骨骨切り術およびBlauth‐Mann変法を行った一例
松居祐樹, 亀田敏明, 小野寺智洋, 寺尾英将, 加藤琢磨, 林晴久, 岩崎倫政, 近藤英司, 川村澄人, 小野寺純, 北村信人, 安田和則, 北海道整形災害外科学会, 132nd, 84, 2017
Japanese

Chevron osteotomyを用いて行った距骨骨軟骨損傷の短期成績
小野寺純, 北村信人, 近藤英司, 小野寺智洋, 岩崎倫政, 上田大輔, 八木知徳, 安田和則, 北海道整形災害外科学会, 132nd, 38, 2017
Japanese

膝屈筋腱ハイブリッド代用材料を用いた解剖学的2束前十字靱帯再建術の臨床成績:術前待機期間の影響
馬場力哉, 近藤英司, 小野寺智洋, 亀田敏明, 岩崎倫政, 小野寺純, 北村信人, 安田和則, 北海道整形災害外科学会, 132nd, 89, 2017
Japanese

遺残組織を温存した解剖学的2束前十字靱帯再建術後のCyclops病変:非温存群との比較
林晴久, 小野寺智洋, 亀田敏明, 加藤琢磨, 岩崎倫政, 近藤英司, 小野寺純, 北村信人, 安田和則, 北海道整形災害外科学会, 132nd, 89, 2017
Japanese

広範な大腿骨内側顆軟骨損傷に対して骨軟骨柱移植および高位脛骨骨切り術を行った一例
五月女慧人, 亀田敏明, 小野寺智洋, 藤田諒, 加藤琢磨, 林晴久, 岩崎倫政, 近藤英司, 小野寺純, 北村信人, 安田和則, 福井孝明, 北海道整形災害外科学会, 132nd, 83, 2017
Japanese

The Effect of Releasing the Superficial Medial Collateral Ligament in Open-Wedge High Tibial Osteotomy: In vivo Study Evaluating Medial Joint Opening by Stress Radiography
SATO Dai, Jpn. J. Joint Dis., 36, 2, 131, 139, 2017
Japanese Society for Joint Diseases, Japanese

豚丹毒生ワクチン針刺し後に右膝慢性滑膜炎をきたした1例　　　　　　　　　　　　　　　
渡辺 尭仁, 小野寺 智洋, 新井 隆太, 亀田 敏明, 薮内 康史, 近藤 英司, 岩崎 倫政, 迫田 義博, 北海道医学雑誌, 91, 2, 88, 89, Nov. 2016
北海道医学会, Japanese

豚丹毒生ワクチン針刺し後に右膝慢性滑膜炎をきたした1例　　　　　　　　　　　　　　　
渡辺 尭仁, 小野寺 智洋, 新井 隆太, 亀田 敏明, 薮内 康史, 近藤 英司, 岩崎 倫政, 迫田 義博, 北海道医学雑誌, 91, 2, 88, 89, Nov. 2016
北海道医学会, Japanese

遺残組織を温存した解剖学的2束前十字靱帯再建術後のCyclops病変:非温存群との比較
林晴久, 近藤英司, 小野寺純, 北村信人, 小野寺智洋, 亀田敏明, 加藤琢磨, 安田和則, 岩崎倫政, 日本関節病学会誌, 35, 3, 289, 14 Oct. 2016
Japanese

学術奨励賞・受賞記念論文 iPS細胞とES細胞の神経分化過程における糖鎖構造の比較
寺島 理代, 小野寺 智洋, 岩崎 倫政, 北海道整形災害外科学会雑誌 : 北海道整形災害外科学会機関誌, 58, 1, 1, 8, Oct. 2016
北海道整形災害外科学会, Japanese

高純度アルギン酸gelを併用した骨髄刺激法の効果 ーbeagle犬骨軟骨欠損モデルを用いてー
馬場力哉, 小野寺智洋, 本谷和俊, 上徳善太, 松原新史, 宝満健太郎, 岩崎倫政, 日本バイオマテリアル学会シンポジウム2016, 2016, 25, Oct. 2016

ultra-purified alginate gel (UPAL gel) を用いたマウスiPS細胞からの軟骨分化誘導
本谷和俊, 小野寺智洋, 寺島理代, 門間太輔, 松岡正剛, 馬場力哉, 上徳善太, 松原新史, 宝満健太郎, 菱村亮介, 金佑泳, 徐亮, 岩崎倫政, 日本バイオマテリアル学会シンポジウム, 2016, 13, Oct. 2016

骨軟骨再生に特異的に作用するケモカインの網羅的解析
上徳善太, 小野寺智洋, 門間太輔, 松岡正剛, 馬場力哉, 本谷和俊, 松原新史, 宝満健太郎, 岩崎倫政, 北海道整形災害外科学会雑誌, 58, 1, 82, 83, Oct. 2016
北海道整形災害外科学会, Japanese, Meeting report

Ultra-purified alginate gel(UPAL gel)を用いたiPS細胞からの軟骨誘導
本谷 和俊, 小野寺 智洋, 寺島 理代, 門間 太輔, 松岡 正剛, 馬場 力哉, 上徳 善太, 松原 新史, 宝満 健太郎, 北海道整形災害外科学会雑誌, 58, 1, 83, 84, Oct. 2016
北海道整形災害外科学会, Japanese

高マンノース型糖鎖構造変化に伴う軟骨変性へのアプローチ
宝満 健太郎, 小野寺 智洋, 門間 太輔, 松岡 正剛, 馬場 力哉, 本谷 和俊, 松原 新史, 上徳 善太, 岩崎 倫政, 北海道整形災害外科学会雑誌, 58, 1, 83, 83, Oct. 2016
北海道整形災害外科学会, Japanese

Return to Sporting Activity After Medial Open-Wedge High Tibial Osteotomy
YABUUCHI Koji, Jpn. J. Joint Dis., 58, 1, 93, 94, Oct. 2016
北海道整形災害外科学会, Japanese

内側楔状開大式高位脛骨骨切り術における内側側副靱帯浅層剥離の影響 定量的膝外反ストレス撮影による検討　　　　　　　　　　　　　　　
佐藤 大, 近藤 英司, 薮内 康史, 小野寺 純, 小野寺 智洋, 亀田 敏明, 八木 知徳, 岩崎 倫政, 安田 和則, 日本関節病学会誌, 35, 3, 252, 252, Oct. 2016
(一社)日本関節病学会, Japanese

当科におけるリウマチ性前足部変形に対する第1MTP関節温存術の治療成績　　　　　　　　　　　　　　　
小野寺 智洋, 林 晴久, 亀田 敏明, 加藤 琢磨, 近藤 英司, 新井 隆太, 岩崎 倫政, 日本足の外科学会雑誌, 37, 2, S180, S180, Oct. 2016
日本足の外科学会, Japanese

鏡視下足関節固定術における術後距腿関節間距離と骨癒合期間との関係　　　　　　　　　　　　　　　
林 晴久, 小野寺 智洋, 近藤 英司, 新井 隆太, 亀田 敏明, 加藤 琢磨, 岩崎 倫政, 日本足の外科学会雑誌, 37, 2, S234, S234, Oct. 2016
日本足の外科学会, Japanese

Vancouver B1大腿骨ステム周囲骨折に対するdual plating法の力学的有用性 力学試験およびFEM解析結果から　　　　　　　　　　　　　　　
高橋 大介, 浅野 毅, 入江 徹, 下段 俊, 亀田 敏明, 薮内 康史, 小野寺 智洋, 岩崎 倫政, 野山 義裕, 近藤 英司, 北海道整形災害外科学会雑誌, 58, 1, 96, 97, Oct. 2016
北海道整形災害外科学会, Japanese

SLE患者における無症候性IONの存在　　　　　　　　　　　　　　　
浅野 毅, 高橋 大介, 入江 徹, 下段 俊, 新井 隆太, 亀田 敏明, 薮内 康史, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 渡邉 俊之, 渥美 達也, 北海道整形災害外科学会雑誌, 58, 1, 98, 99, Oct. 2016
北海道整形災害外科学会, Japanese

人工股関節全置換術後深部静脈血栓症発生率のアプローチによる違い　　　　　　　　　　　　　　　
入江 徹, 高橋 大介, 浅野 毅, 新井 隆太, 亀田 敏明, 下段 俊, 薮内 康史, 小野寺 智洋, 岩崎 倫政, 高橋 要, 安藤 亮, 紺野 拓也, 近藤 英司, 北海道整形災害外科学会雑誌, 58, 1, 100, 101, Oct. 2016
北海道整形災害外科学会, Japanese

THA術前のJHEQ scoreにおける術後改善度予測因子の検証　　　　　　　　　　　　　　　
下段 俊, 入江 徹, 高橋 大介, 浅野 毅, 新井 隆太, 亀田 敏明, 藪内 康史, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 58, 1, 101, 101, Oct. 2016
北海道整形災害外科学会, Japanese

8-plateを用いた成長抑制術を行い脚長調整に2年を要した下肢片側肥大症の一例　　　　　　　　　　　　　　　
甲斐原 拓真, 小野寺 智洋, 近藤 英司, 薮内 康史, 亀田 敏明, 岩崎 倫政, 北海道整形災害外科学会雑誌, 58, 1, 137, 138, Oct. 2016
北海道整形災害外科学会, Japanese

内側楔状開大式高位脛骨骨切り術後のスポーツ復帰に関する検討　　　　　　　　　　　　　　　
薮内 康史, 小野寺 智洋, 亀田 敏明, 岩崎 倫政, 小野寺 純, 横田 正司, 北村 信人, 安田 和則, 八木 知徳, 近藤 英司, 北海道整形災害外科学会雑誌, 58, 1, 93, 94, Oct. 2016
北海道整形災害外科学会, Japanese

The establishment of the novel mechanical stress model in three dimensional culture.　　　　　　　　　　　　　　　
S. Matsubara, T. Onodera, E. Maeda, D. Momma, M. Matsuoka, R. Baba, K. Hontani, Z. Joutoku, K. Homan, T. Ohashi, N. Iwasaki, The13th World Congress of International Chemical Reference Substances (ICRS), Sep. 2016
English

The Efficacy of Chondrogenic differentiation with ultra-purified alginate gel (UPAL gel) for mouse iPS cells in vitro and in vivo.　　　　　　　　　　　　　　　
K. Hontani, T. Onodera, D. Momma, M. Matsuoka, R. Baba, Z. Joutoku, S. Matsubara, K. Homan, R. Hishimura, N. Iwasaki, The13th World Congress of International Chemical Reference Substances (ICRS), Sep. 2016
English

内側楔状開大式高位脛骨骨切り術後の膝蓋大腿関節における応力変化 CT osteoabsorptiometry法を用いて
亀田 敏明, 近藤 英司, 小野寺 純, 小野寺 智洋, 安田 和則, 岩崎 倫政, 中部日本整形外科災害外科学会雑誌, 59, 秋季学会, 243, 243, Sep. 2016
中部日本整形外科災害外科学会, Japanese

高位脛骨骨切り術における深部静脈血栓症の検討　　　　　　　　　　　　　　　
小池 良直, 亀田 敏明, 近藤 英司, 藪内 康史, 小野寺 智洋, 岩崎 倫政, 中部日本整形外科災害外科学会雑誌, 59, 秋季学会, 244, 244, Sep. 2016
中部日本整形外科災害外科学会, Japanese

鏡視下膝靱帯再建術後における急性関節内感染 同一施設における10年間の検討　　　　　　　　　　　　　　　
亀田 敏明, 近藤 英司, 小野寺 純, 小野寺 智洋, 安田 和則, 岩崎 倫政, 中部日本整形外科災害外科学会雑誌, 59, 秋季学会, 254, 254, Sep. 2016
中部日本整形外科災害外科学会, Japanese

定量的膝外反ストレス撮影による膝内側側副靱帯浅層の生体力学的評価 内側楔状開大式高位脛骨骨切り術における検討　　　　　　　　　　　　　　　
薮内 康史, 佐藤 大, 近藤 英司, 小野寺 純, 小野寺 智洋, 亀田 敏明, 北村 信人, 八木 知徳, 岩崎 倫政, 安田 和則, 日本整形外科学会雑誌, 90, 8, S1767, S1767, Aug. 2016
(公社)日本整形外科学会, Japanese

内側楔状開大式高位脛骨骨切り術後の膝蓋大腿関節における応力変化 CT osteoabsorptiometry法を用いて　　　　　　　　　　　　　　　
亀田 敏明, 近藤 英司, 薮内 康史, 小野寺 純, 小野寺 智洋, 北村 信人, 八木 知徳, 安田 和則, 岩崎 倫政, 日本整形外科学会雑誌, 90, 8, S1826, S1826, Aug. 2016
(公社)日本整形外科学会, Japanese

内側楔状開大式高位脛骨骨切り術における内側側副靱帯浅層剥離の影響 定量的膝外反ストレス撮影による検討　　　　　　　　　　　　　　　
佐藤 大, 薮内 康史, 近藤 英司, 小野寺 純, 小野寺 智洋, 亀田 敏明, 北村 信人, 八木 知徳, 岩崎 倫政, 安田 和則, JOSKAS, 41, 4, 192, 192, Jul. 2016
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

高位脛骨骨切り術後における深部静脈血栓症の検討　　　　　　　　　　　　　　　
小池 良直, 亀田 敏明, 近藤 英司, 薮内 康史, 小野寺 智洋, 安田 和則, 岩崎 倫政, JOSKAS, 41, 4, 239, 239, Jul. 2016
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

自家培養軟骨細胞移植(JACC)の短期成績　　　　　　　　　　　　　　　
甲斐原 拓真, 薮内 康史, 近藤 英司, 小野寺 智洋, 亀田 敏明, 岩崎 倫政, 安田 和則, JOSKAS, 41, 4, 340, 340, Jul. 2016
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

鏡視下膝靱帯再建術後における急性関節内感染 同一施設における10年間の検討　　　　　　　　　　　　　　　
亀田 敏明, 近藤 英司, 小野寺 純, 小野寺 智洋, 薮内 康史, 北村 信人, 安田 和則, 岩崎 倫政, JOSKAS, 41, 4, 531, 531, Jul. 2016
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

北海道における足の外科 北海道大学での足の外科
小野寺 智洋, 亀田 敏明, 薮内 康史, 近藤 英司, 岩崎 倫政, 北海道整形災害外科学会雑誌, 57, 2, 216, 219, Apr. 2016
北海道整形災害外科学会, Japanese

TKA後の膝関節kinematic patternに影響を与える術前因子の検討　　　　　　　　　　　　　　　
清藤 直樹, 小野寺 智洋, 笠原 靖彦, 西尾 悠介, 岩崎 倫政, 近藤 英司, 眞島 任史, 北海道整形災害外科学会雑誌, 57, 2, 318, 319, Apr. 2016
北海道整形災害外科学会, Japanese

特発性膝骨壊死(Spontaneous osteonecrosis of the knee)に対する骨軟骨柱移植術の治療成績　　　　　　　　　　　　　　　
薮内 康史, 小野寺 智洋, 清藤 直樹, 高橋 大介, 入江 徹, 浅野 毅, 新井 隆太, 中野 宏昭, 深谷 英昭, 岩崎 倫政, 近藤 英司, 眞島 任史, 笠原 靖彦, 北海道整形災害外科学会雑誌, 57, 2, 325, 326, Apr. 2016
北海道整形災害外科学会, Japanese

著しく増生した滑膜により膝蓋骨脱臼を呈した膝関節滑膜炎の一例　　　　　　　　　　　　　　　
新井 隆太, 小野寺 智洋, 清藤 直樹, 高橋 大介, 入江 徹, 浅野 毅, 深谷 英昭, 中野 宏昭, 藪内 康史, 岩崎 倫政, 近藤 英司, 安田 和則, 北海道整形災害外科学会雑誌, 57, 2, 327, 327, Apr. 2016
北海道整形災害外科学会, Japanese

恒久性膝蓋骨脱臼にGreen変法及びBlauth法合併手術を施行した1例　　　　　　　　　　　　　　　
濱崎 雅成, 清藤 直樹, 小野寺 智洋, 中野 宏昭, 深谷 英昭, 薮内 康史, 岩崎 倫政, 近藤 英司, 眞島 任史, 北海道整形災害外科学会雑誌, 57, 2, 328, 328, Apr. 2016
北海道整形災害外科学会, Japanese

変形性足関節症とリウマチ性足関節症における鏡視下足関節固定術の臨床成績の比較　　　　　　　　　　　　　　　
小野寺 智洋, 清藤 直樹, 深谷 英昭, 中野 宏昭, 薮内 康史, 新井 隆太, 藤田 諒, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 57, 2, 329, 330, Apr. 2016
北海道整形災害外科学会, Japanese

リウマチ性足関節症に対するIlizarov創外固定器を用いた足関節固定術と鏡視下足関節固定術の比較検討　　　　　　　　　　　　　　　
深谷 英昭, 小野寺 智洋, 清藤 直樹, 中野 宏昭, 薮内 康史, 新井 隆太, 高橋 大介, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 57, 2, 330, 330, Apr. 2016
北海道整形災害外科学会, Japanese

リウマチ性前足部変形に対する切除関節形成術における術後再脱臼因子の検討　　　　　　　　　　　　　　　
中野 宏昭, 小野寺 智洋, 清藤 直樹, 深谷 英昭, 新井 隆太, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 57, 2, 330, 331, Apr. 2016
北海道整形災害外科学会, Japanese

著明な骨欠損を伴うTHA再置換術後感染性ゆるみに対しTeriparatideを併用して二期的再置換術を施行した1例　　　　　　　　　　　　　　　
浅野 毅, 高橋 大介, 入江 徹, 中野 宏昭, 新井 隆太, 清藤 直樹, 深谷 英昭, 薮内 康史, 小野寺 智洋, 岩崎 倫政, 安藤 亮, 紺野 拓也, 近藤 英司, 北海道整形災害外科学会雑誌, 57, 2, 375, 375, Apr. 2016
北海道整形災害外科学会, Japanese

特発性大腿骨頭壊死症と大腿骨軟骨下脆弱性骨折の患者背景の検討　　　　　　　　　　　　　　　
薮内 康史, 入江 徹, 高橋 大介, 浅野 毅, 新井 隆太, 清藤 直樹, 中野 宏昭, 深谷 英昭, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 57, 2, 381, 382, Apr. 2016
北海道整形災害外科学会, Japanese

特発性大腿骨頭壊死症の骨頭圧潰進行はMRIで予測可能か?　　　　　　　　　　　　　　　
入江 徹, 高橋 大介, 浅野 毅, 中野 宏昭, 新井 隆太, 清藤 直樹, 深谷 英昭, 薮内 康史, 小野寺 智洋, 岩崎 倫政, 安藤 亮, 紺野 拓也, 井上 正弘, 近藤 英司, 北海道整形災害外科学会雑誌, 57, 2, 382, 383, Apr. 2016
北海道整形災害外科学会, Japanese

前十字靱帯損傷に広範な大腿骨外側顆軟骨損傷および外側壁の陥凹骨折を合併した1例　　　　　　　　　　　　　　　
清藤 直樹, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 三上 将, 安田 和則, 北海道整形災害外科学会雑誌, 57, 2, 406, 406, Apr. 2016
北海道整形災害外科学会, Japanese

Comprehensive Screening of Chemokines Related to Articular Cartilage Repair.　　　　　　　　　　　　　　　
Zenta Joutoku, Tomohiro Onodera, Daisuke Momma, Masatake Matsuoka, Rikiya Baba, Kazutoshi Hontani, Shinji Matsubara, Kentaro Homan, Ryosuke Hishimura, WooYoung Kim, Norimasa Iwasaki, The 62th Annual Meeting of Orthopaedic Research Society (ORS), Mar. 2016
Japanese

Depletion of Gangliosides Accelerated the Articular Cartilage Repair Through Indian Hedgehog Pathway.　　　　　　　　　　　　　　　
Masatake Matsuoka, Tomohiro Onodera, Fumio Sasazawa, Daisuke Momma, Rikiya Baba, Kazutoshi Hontani, Zenta Joutoku, Shinji Matsubara, Kentaro Homan, Norimasa Iwasaki, The 62th Annual Meeting of Orthopaedic Research Society (ORS), Mar. 2016
English

Depletion of High-mannose Type N-glycans Lead to Cartilage Degradation.　　　　　　　　　　　　　　　
Kentaro Homan, Tomohiro Onodera, Rikiya Baba, Daisuke Momma, Masatake Matsuoka, Kazutoshi Hontani, Shinji Matsubara, Zenta Joutoku, Ryosuke Hishimura, Kim WooYoung, Norimasa Iwasaki, The 62th Annual Meeting of Orthopaedic Research Society (ORS), Mar. 2016
English

大腿骨頭軟骨下脆弱性骨折の予後予測因子の検討 免荷保存治療は効果があるのか　　　　　　　　　　　　　　　
高橋 大介, 入江 徹, 浅野 毅, 下段 俊, 新井 隆太, 亀田 敏明, 薮内 康史, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 90, 2, S124, S124, Mar. 2016
(公社)日本整形外科学会, Japanese

SLE患者における無症候性IONの存在　　　　　　　　　　　　　　　
浅野 毅, 高橋 大介, 入江 徹, 下段 俊, 新井 隆太, 薮内 康史, 亀田 敏明, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 90, 2, S127, S127, Mar. 2016
(公社)日本整形外科学会, Japanese

人工股関節全置換術後における患者立脚型評価と医師主導型評価の各要素の相関性の検討　　　　　　　　　　　　　　　
下段 俊, 入江 徹, 高橋 大介, 浅野 毅, 安藤 亮, 紺野 拓也, 亀田 敏明, 新井 隆太, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 90, 3, S765, S765, Mar. 2016
(公社)日本整形外科学会, Japanese

非定型大腿骨骨折19例の検討 骨折部位別の比較検討　　　　　　　　　　　　　　　
吉田 朋世, 高橋 大介, 入江 徹, 浅野 毅, 梅本 貴央, 田辺 明彦, 宮崎 拓自, 山本 励志, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 90, 3, S825, S825, Mar. 2016
(公社)日本整形外科学会, Japanese

人工股関節全置換術後深部静脈血栓症の発生率 前側方アプローチと後側方アプローチの比較検討　　　　　　　　　　　　　　　
入江 徹, 高橋 大介, 浅野 毅, 下段 俊, 安藤 亮, 紺野 拓也, 亀田 敏明, 新井 隆太, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 90, 3, S932, S932, Mar. 2016
(公社)日本整形外科学会, Japanese

リウマチ性前足部変形に対する第2-5中足骨骨頭切除関節形成術における術後再脱臼リスク因子の検討　　　　　　　　　　　　　　　
小野寺 智洋, 中野 宏昭, 近藤 英司, 亀田 敏明, 薮内 康史, 岩崎 倫政, 日本整形外科学会雑誌, 90, 3, S943, S943, Mar. 2016
(公社)日本整形外科学会, Japanese

Locking plateを用いた内側楔状開大式高位脛骨骨切り術の中期成績と合併症　　　　　　　　　　　　　　　
薮内 康史, 近藤 英司, 小野寺 純, 小野寺 智洋, 亀田 敏明, 北村 信人, 八木 知徳, 安田 和則, 岩崎 倫政, 日本整形外科学会雑誌, 90, 3, S960, S960, Mar. 2016
(公社)日本整形外科学会, Japanese

ガングリオシド欠損はIndian hedgehog pathwayを介し軟骨の肥大化を抑制する
松岡正剛, 小野寺智洋, 笹沢史生, 門間太輔, 馬場力哉, 本谷和俊, 上徳善太, 松原新史, 宝満健太郎, 岩崎倫政, 日本軟骨代謝学会プログラム・抄録集, 29th, 136, Feb. 2016
Japanese

軟骨修復に関連するケモカインの網羅的解析
上徳善太, 小野寺智洋, 門間太輔, 松岡正剛, 馬場力哉, 本谷和俊, 松原新史, 宝満健太郎, 菱村亮介, 岩崎倫政, 第29回日本軟骨代謝学会, 90, 8, 138, Feb. 2016
Japanese

三次元培養下における伸長ストレス負荷モデルの確立　　　　　　　　　　　　　　　
松原新史, 小野寺智洋, 門間太輔, 松岡正剛, 馬場力哉, 本谷和俊, 上徳善太, 宝満健太郎, 菱村亮介, キムウヨン, 岩崎倫政, 第29回日本軟骨代謝学会, 129, Feb. 2016
Japanese

Ultra-purified alginate gel (UPAL gel)と多段階分化誘導法を併用したマウスiPS細胞の生体内における軟骨分化誘導
本谷和俊, 小野寺智洋, 寺島理代, 門間太輔, 松岡正剛, 馬場力哉, 上徳善太, 松原新史, 宝満健太郎, 菱村亮介, 岩崎倫政, 第29回日本軟骨代謝学会, 29th, 114, Feb. 2016
Japanese

軟骨細胞の高マンノース型糖鎖の減少は生体内で軟骨変性を惹起する
宝満健太郎, 小野寺智洋, 門間太輔, 松岡正剛, 馬場力哉, 本谷和俊, 松原新史, 上徳善太, 菱村亮介, 金佑泳, 岩崎倫政, 第29回日本軟骨代謝学会, 29th, 109, Feb. 2016
Japanese

高純度アルギン酸ゲルを併用した骨髄刺激法による家兎骨軟骨欠損の修復効果-コラーゲンの配向性と力学強度に着目して-
馬場力哉, 小野寺智洋, 門間太輔, 松岡正剛, 本谷和俊, 遠藤香織, 東藤正浩, 但野茂, 岩崎倫政, 日本軟骨代謝学会プログラム・抄録集, 29th, 2016

大腿骨転子間弯曲内反骨切り術が股関節外転角に与える影響
下段俊, 入江徹, 高橋大介, 浅野毅, 新井隆太, 亀田敏明, 小野寺智洋, 近藤英司, 岩崎倫政, 北海道整形災害外科学会, 130th, 90, 2016
Japanese

ハイブリッド型人工股関節の術後10年以上成績
入江徹, 高橋大介, 浅野毅, 下段俊, 亀田敏明, 安藤亮, 紺野拓也, 新井隆太, 小野寺智洋, 近藤英司, 岩崎倫政, 日本人工関節学会プログラム・抄録集, 46th, 345, 2016
Japanese

In vivoにおける高純度アルギン酸ゲルと多段階分化誘導法を併用したマウスiPS細胞軟骨分化誘導　　　　　　　　　　　　　　　
本谷和俊, 小野寺智洋, 寺島理代, 門間太輔, 松岡正剛, 馬場力哉, 上徳善太, 松原新史, 宝満健太郎, 菱村亮介, 岩崎倫政, 日本整形外科学会雑誌, 90, 8, S1486, S1486, 2016
(公社)日本整形外科学会, Japanese

高純度アルギン酸ゲルと多段階分化誘導法を併用したマウスiPS細胞軟骨分化誘導　　　　　　　　　　　　　　　
本谷和俊, 小野寺智洋, 寺島理代, 門間太輔, 松岡正剛, 馬場力哉, 上徳善太, 松原新史, 宝満健太郎, 菱村亮介, 金佑泳, 岩崎倫政, 北海道整形災害外科学会雑誌, 58, suppl-2, 27, 2016
Japanese

骨軟骨修復に関連するケモカインの網羅的解析
上徳善太, 小野寺智洋, 門間太輔, 松岡正剛, 馬場力哉, 本谷和俊, 松原新史, 宝満健太郎, 岩崎倫政, 北海道整形災害外科学会雑誌, 58, suppl-2, 26, 2016
Japanese

豚丹毒生ワクチン針刺し後に右膝慢性非特異性滑膜炎をきたした1例
渡辺尭仁, 小野寺智洋, 新井隆太, 迫田義博, 亀田敏明, 薮内康史, 近藤英司, 岩崎倫政, 北海道整形災害外科学会, 131st, 103, 2016
Japanese

Return to Sporting Activity After Medial Open-Wedge High Tibial Osteotomy
YABUUCHI Koji, Jpn. J. Joint Dis., 35, 2, 149, 154, 2016
<p><b>Objective</b>: The purpose of this study was to evaluate sporting activity and clinical outcome following medial open-wedge high tibial osteotomy (OWHTO) in middle and older-aged patients with medial osteoarthritis (OA).</p><p><b>Methods</b>: Between 2009 and 2014, 22 patients (25 knees) who underwent OWHTO with a locking plate were enrolled in this study. All patients were active in sports on a regular basis prior to surgery, but were unable to perform sports at the time of surgery. Inclusion criteria involved patients who had medial OA or spontaneous osteonecrosis of the knee. There were 10 men and 12 women with a mean age of 60.3 years (range: 41-74 years) at the time of surgery. We performed a biplanar osteotomy of the tibia intraoperatively. A beta-TCP spacer was implanted in the opening space. Then, a locking plate was implanted onto the tibia. All patients underwent sporting activities, clinical and radiological examinations, with determinations of complications prior to surgery and at the final follow up periods after surgery (mean 37.2 months, range: 13.0-73.1 months).</p><p><b>Results</b>: Postoperatively, the mean Japan Orthopaedic Association score significantly improved from 68.2 to 92.6 points (Total score: 100 points, <i>P</i><0.001). The Tegner activity level scale did not show significant changes pre- and postoperatively (4.1 to 3.8). However, three patients who engaged in high impact sports (competitive skiing and marathon) had decreased Tegner activity level scale after surgery.</p><p><b>Conclusion</b>: The present study has demonstrated that OWHTO for the treatment of OA in middle and older-aged patients significantly improved the short-term clinical outcome and allowed patients to return to sporting activities similar to their preoperative levels.</p>, Japanese Society for Joint Diseases, Japanese

高純度硬化性ゲルを用いた低侵襲軟骨再生治療法の開発
岩崎 倫政, 小野寺 智洋, 馬場 力哉, 人工臓器, 45, 1, 75, 77, 2016
一般社団法人 日本人工臓器学会, Japanese

人工膝関節再置換術後感染症治療経過中に薬剤性過敏症症候群を発症した1例　　　　　　　　　　　　　　　
高橋 要, 上徳 善太, 入江 徹, 笠原 靖彦, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 57, 1, 121, 122, Dec. 2015
北海道整形災害外科学会, Japanese

特発性大腿骨頭壊死症患者のTHA術後満足度は可動域に影響される JHEQとJOA scoreを用いた検討　　　　　　　　　　　　　　　
入江 徹, 高橋 大介, 浅野 毅, 新井 隆太, 清藤 直樹, 中野 宏昭, 深谷 英昭, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 57, 1, 125, 126, Dec. 2015
北海道整形災害外科学会, Japanese

TKA術中のACL・半月板切除はkinematics patternに影響しない　　　　　　　　　　　　　　　
清藤 直樹, 小野寺 智洋, 笠原 靖彦, 西尾 悠介, 岩崎 倫政, 近藤 英司, 眞島 任史, 北海道整形災害外科学会雑誌, 57, 1, 131, 131, Dec. 2015
北海道整形災害外科学会, Japanese

Mobile bearing型TKAは術後non-medial pivot kinematics膝に対して膝蓋大腿関節圧を減少させる　　　　　　　　　　　　　　　
小野寺 智洋, 清藤 直樹, 西尾 悠介, 中野 宏昭, 深谷 英昭, 薮内 康史, 岩崎 倫政, 近藤 英司, 眞島 任史, 北海道整形災害外科学会雑誌, 57, 1, 131, 132, Dec. 2015
北海道整形災害外科学会, Japanese

腫瘍性骨軟化症の3例　　　　　　　　　　　　　　　
山本 励志, 新井 隆太, 笠原 靖彦, 小野寺 智洋, 高橋 大介, 入江 徹, 浅野 毅, 清藤 直樹, 中野 宏昭, 深谷 英昭, 岩崎 倫政, 近藤 英司, 西尾 悠介, 安田 和則, 北海道整形災害外科学会雑誌, 57, 1, 176, 177, Dec. 2015
北海道整形災害外科学会, Japanese

大腿骨転子間彎曲内反骨切り術における脚短縮理論モデルとその評価　　　　　　　　　　　　　　　
浅野 毅, 高橋 大介, 入江 徹, 新井 隆太, 清藤 直樹, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 57, 1, 180, 181, Dec. 2015
北海道整形災害外科学会, Japanese

特発性大腿骨頭壊死症に併発した大腿骨頸部骨折に骨接合術で治療した2例　　　　　　　　　　　　　　　
深谷 英昭, 高橋 大介, 入江 徹, 浅野 毅, 新井 隆太, 清藤 直樹, 小野寺 智洋, 岩崎 倫政, 近藤 英司, 北海道整形災害外科学会雑誌, 57, 1, 183, 184, Dec. 2015
北海道整形災害外科学会, Japanese

関節リウマチ患者の後足部変形に対する鏡視下足関節固定術の短期成績　　　　　　　　　　　　　　　
藤田 諒, 小野寺 智洋, 笠原 靖彦, 高橋 大介, 清藤 直樹, 浅野 毅, 新井 隆太, 近藤 英司, 岩崎 倫政, 北海道整形災害外科学会雑誌, 57, 1, 196, 197, Dec. 2015
北海道整形災害外科学会, Japanese

恒久性膝蓋骨脱臼にGreen変法及びBlauth法合併手術を施行した1例　　　　　　　　　　　　　　　
濱崎 雅成, 小野寺 智洋, 清藤 直樹, 中野 宏明, 深谷 英明, 薮内 康史, 岩崎 倫政, 近藤 英司, 眞島 任史, 北海道整形災害外科学会雑誌, 57, 1, 201, 201, Dec. 2015
北海道整形災害外科学会, Japanese

リウマチ性前足部変形に対する切除関節形成術における術後再脱臼因子の検討　　　　　　　　　　　　　　　
中野 宏昭, 小野寺 智洋, 清藤 直樹, 深谷 英昭, 新井 隆太, 近藤 英司, 岩崎 倫政, 北海道医学雑誌, 90, 2, 144, 145, Nov. 2015
北海道医学会, Japanese

【整形外科領域における移植医療】 骨および軟骨に対する人工・生体材料、組織細胞移植の臨床成績 四肢外傷および傷病 大腿骨顆部特発性骨壊死に対する骨軟骨柱移植術の中・長期成績　　　　　　　　　　　　　　　
笠原 靖彦, 小野寺 智洋, 薮内 康史, 近藤 英司, 岩崎 倫政, 眞島 任史, 別冊整形外科, 68, 130, 133, Oct. 2015
(株)南江堂, Japanese

成績の評価に基づいたこれからの人工股関節置換術は? 当科における初回ハイブリッド人工股関節全置換術の長期成績　　　　　　　　　　　　　　　
入江 徹, 高橋 大介, 浅野 毅, 下段 俊, 亀田 敏明, 薮内 康史, 新井 隆太, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 日本関節病学会誌, 34, 3, 332, 332, Oct. 2015
(一社)日本関節病学会, Japanese

軟骨下脆弱性骨折の病態と治療 大腿骨頭軟骨下脆弱性骨折に対する免荷治療は効果があるのか 予後予測因子の検討　　　　　　　　　　　　　　　
高橋 大介, 入江 徹, 浅野 毅, 新井 隆太, 下段 俊, 亀田 敏明, 藪内 康史, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 日本関節病学会誌, 34, 3, 338, 338, Oct. 2015
(一社)日本関節病学会, Japanese

SLE患者における無症候性IONの存在　　　　　　　　　　　　　　　
浅野 毅, 高橋 大介, 入江 徹, 下段 俊, 新井 隆太, 亀田 敏明, 薮内 康史, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 日本関節病学会誌, 34, 3, 342, 342, Oct. 2015
(一社)日本関節病学会, Japanese

内側楔状開大式高位脛骨骨切り術後のスポーツ復帰に関する検討　　　　　　　　　　　　　　　
薮内 康史, 近藤 英司, 小野寺 智洋, 亀田 敏明, 北村 信人, 八木 知徳, 安田 和則, 岩崎 倫政, 日本関節病学会誌, 34, 3, 463, 463, Oct. 2015
(一社)日本関節病学会, Japanese

人工股関節全置換術後深部静脈血栓症の前側方アプローチと後側方アプローチ間での発生率状況の比較検討　　　　　　　　　　　　　　　
入江 徹, 高橋 大介, 浅野 毅, 下段 俊, 高橋 要, 亀田 敏明, 新井 隆太, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 日本関節病学会誌, 34, 3, 500, 500, Oct. 2015
(一社)日本関節病学会, Japanese

高純度アルギン酸ゲルを併用した骨髄刺激法の効果 家兎骨軟骨欠損モデルを用いて　　　　　　　　　　　　　　　
馬場 力哉, 小野寺 智洋, 門間 太輔, 松岡 正剛, 本谷 和俊, 遠藤 香織, 東藤 正浩, 但野 茂, 岩崎 倫政, 日本整形外科学会雑誌, 89, 8, S1592, S1592, Sep. 2015
(公社)日本整形外科学会, Japanese

Vancouver B1大腿骨ステム周囲骨折に対するdual plating法の力学的有用性 力学試験およびFEM解析結果から　　　　　　　　　　　　　　　
高橋 大介, 浅野 毅, 入江 徹, 野山 義裕, 下段 俊, 新井 隆太, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 89, 8, S1552, S1552, Sep. 2015
(公社)日本整形外科学会, Japanese

外反母趾変形矯正手術後の遠位指節間関節外反変形の検討　　　　　　　　　　　　　　　
松岡 正剛, 小野寺 智洋, 山崎 修司, 近藤 英司, 岩崎 倫政, 日本足の外科学会雑誌, 36, 2, S259, S259, Sep. 2015
日本足の外科学会, Japanese

Lapidus変法において第1中足骨短縮量は母趾臨床成績を向上させる　　　　　　　　　　　　　　　
小野寺 智洋, 松岡 正剛, 山崎 修司, 近藤 英司, 岩崎 倫政, 日本足の外科学会雑誌, 36, 2, S260, S260, Sep. 2015
日本足の外科学会, Japanese

内側楔状開大式高位脛骨骨切り術後のスポーツ復帰に関する検討　　　　　　　　　　　　　　　
薮内 康史, 近藤 英司, 小野寺 智洋, 亀田 敏明, 小野寺 純, 北村 信人, 安田 和則, 八木 知徳, 岩崎 倫政, 日本整形外科スポーツ医学会雑誌, 35, 4, 326, 326, Aug. 2015
(一社)日本整形外科スポーツ医学会, Japanese

前十字靱帯損傷および大腿骨外側顆骨軟骨損傷に対し解剖学的2束靱帯再建術・腸骨移植・自家培養軟骨移植を一期的に施行した1例　　　　　　　　　　　　　　　
清藤 直樹, 近藤 英司, 三上 将, 小野寺 智洋, 岩崎 倫政, 安田 和則, 日本整形外科スポーツ医学会雑誌, 35, 4, 351, 351, Aug. 2015
(一社)日本整形外科スポーツ医学会, Japanese

4ヵ月健診はDDHスクリーニングに適切な時期なのか?　　　　　　　　　　　　　　　
高橋 大介, 浅野 毅, 新井 隆太, 小野寺 智洋, 笠原 靖彦, 岩崎 倫政, 井上 正弘, 紺野 拓也, 入江 徹, 西尾 悠介, 近藤 英司, 北海道整形災害外科学会雑誌, 56, 2, 244, 244, Jul. 2015
北海道整形災害外科学会, Japanese

大腿骨転子間彎曲内反骨切り術の短期成績 楔状内反骨切り術との比較　　　　　　　　　　　　　　　
浅野 毅, 高橋 大介, 新井 隆太, 笠原 靖彦, 小野寺 智洋, 近藤 英司, 清藤 直樹, 岩崎 倫政, 北海道整形災害外科学会雑誌, 56, 2, 249, 249, Jul. 2015
北海道整形災害外科学会, Japanese

人工股関節置換術後のJHEQとJOA scoreの比較検討　　　　　　　　　　　　　　　
太田 昌博, 高橋 大介, 浅野 毅, 辻本 武尊, 新井 隆太, 清藤 直樹, 小野寺 智洋, 笠原 靖彦, 近藤 英司, 岩崎 倫政, 北海道整形災害外科学会雑誌, 56, 2, 254, 254, Jul. 2015
北海道整形災害外科学会, Japanese

3次元プリンターを用いた人工股関節全置換術における術前計画の有用性　　　　　　　　　　　　　　　
宮崎 拓自, 高橋 大介, 近藤 英司, 笠原 靖彦, 小野寺 智洋, 浅野 毅, 清藤 直樹, 新井 隆太, 岩崎 倫政, 北海道整形災害外科学会雑誌, 56, 2, 255, 256, Jul. 2015
北海道整形災害外科学会, Japanese

S-ROM THAにおけるZTT II cupライナーの長期成績　　　　　　　　　　　　　　　
新井 隆太, 高橋 大介, 入江 徹, 浅野 毅, 笠原 靖彦, 小野寺 智洋, 清藤 直樹, 岩崎 倫政, 井上 正弘, 紺野 拓也, 西尾 悠介, 近藤 英司, 安田 和則, 眞島 任史, 北海道整形災害外科学会雑誌, 56, 2, 256, 257, Jul. 2015
北海道整形災害外科学会, Japanese

高度麻痺性尖足変形に対して創外固定装着下に鏡視下足関節固定術を施行した1例　　　　　　　　　　　　　　　
小林 英之, 小野寺 智洋, 笠原 靖彦, 清藤 直樹, 高橋 大介, 浅野 毅, 新井 隆太, 岩崎 倫政, 西尾 悠介, 近藤 英司, 北海道整形災害外科学会雑誌, 56, 2, 307, 307, Jul. 2015
北海道整形災害外科学会, Japanese

関節リウマチによる高度外反変形膝と末期足関節症に対して一期的手術を施行した1例　　　　　　　　　　　　　　　
松原 新史, 小野寺 智洋, 西尾 悠介, 紺野 拓也, 笠原 靖彦, 高橋 大介, 近藤 英司, 岩崎 倫政, 眞島 任史, 北海道整形災害外科学会雑誌, 56, 2, 307, 308, Jul. 2015
北海道整形災害外科学会, Japanese

外傷性膝関節脱臼後に内反型OAが進行した1例　　　　　　　　　　　　　　　
清藤 直樹, 笠原 靖彦, 小野寺 智洋, 高橋 大介, 浅野 毅, 新井 隆太, 岩崎 倫政, 西尾 悠介, 近藤 英司, 眞島 任史, 北海道整形災害外科学会雑誌, 56, 2, 308, 309, Jul. 2015
北海道整形災害外科学会, Japanese

Medial Open-Wedge HTOにおいて用いる人工骨の臨床評価 ハイドロキシアパタイトvs β-リン酸三カルシウム　　　　　　　　　　　　　　　
小野寺 純, 近藤 英司, 北村 信人, 安田 和則, 上田 大輔, 大水 信幸, 八木 知徳, 笠原 靖彦, 小野寺 智洋, 岩崎 倫政, 北海道整形災害外科学会雑誌, 56, 2, 310, 311, Jul. 2015
北海道整形災害外科学会, Japanese

膝窩動脈捕捉症候群に対し、観血的治療を行った1例　　　　　　　　　　　　　　　
藤田 諒, 笠原 靖彦, 入江 徹, 小野寺 智洋, 高橋 大介, 清藤 直樹, 浅野 毅, 新井 隆太, 近藤 英司, 岩崎 倫政, 北海道整形災害外科学会雑誌, 56, 2, 311, 311, Jul. 2015
北海道整形災害外科学会, Japanese

人工膝関節全置換術後深部感染に対してIlizarov創外固定器を用いた膝関節固定術を行った1例　　　　　　　　　　　　　　　
百貫 亮太, 小野寺 純, 近藤 英司, 北村 信人, 安田 和則, 小野寺 智洋, 笠原 靖彦, 岩崎 倫政, 八木 知徳, 門司 順一, 北海道整形災害外科学会雑誌, 56, 2, 311, 312, Jul. 2015
北海道整形災害外科学会, Japanese

当科における単顆型人工膝関節置換術の短期成績 New Knee Society Scoreを用いて　　　　　　　　　　　　　　　
笠原 靖彦, 小野寺 智洋, 清藤 直樹, 高橋 大介, 浅野 毅, 新井 隆太, 岩崎 倫政, 西尾 悠介, 近藤 英司, 眞島 任史, 北海道整形災害外科学会雑誌, 56, 2, 315, 316, Jul. 2015
北海道整形災害外科学会, Japanese

人工膝関節置換術において大腿骨顆部と脛骨後縁との相対的位置関係は屈曲拘縮の程度と相関する　　　　　　　　　　　　　　　
小野寺 智洋, 笠原 靖彦, 清藤 直樹, 高橋 大介, 浅野 毅, 新井 隆太, 岩崎 倫政, 西尾 悠介, 近藤 英司, 眞島 任史, 北海道整形災害外科学会雑誌, 56, 2, 319, 320, Jul. 2015
北海道整形災害外科学会, Japanese

TKA後の膝関節kinematics patternは術前のkinematics patternに依存する　　　　　　　　　　　　　　　
清藤 直樹, 笠原 靖彦, 小野寺 智洋, 高橋 大介, 浅野 毅, 新井 隆太, 岩崎 倫政, 西尾 悠介, 近藤 英司, 眞島 任史, 北海道整形災害外科学会雑誌, 56, 2, 321, 322, Jul. 2015
北海道整形災害外科学会, Japanese

全身痛を呈した足底部軟部腫瘍の1例
ARAI RYUTA, ONODERA TOMOHIRO, MITSUHASHI TOMOKO, TAKAHASHI DAISUKE, IRIE TOORU, ASANO TAKESHI, KIYOFUJI NAOKI, MATSUBARA SHINJI, YAMAMOTO REIJI, KONDO EIJI, IWASAKI NORIMASA, 日本整形外科学会雑誌, 89, 6, S1257, S1257, 05 Jun. 2015
(公社)日本整形外科学会, Japanese

膝前十字靱帯損傷への取り組み 遺残組織を温存した解剖学的2束前十字靱帯再建術　　　　　　　　　　　　　　　
近藤 英司, 小野寺 純, 横田 正司, 北村 信人, 小野寺 智洋, 岩崎 倫政, 安田 和則, JOSKAS, 40, 4, 324, 324, Jun. 2015
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

特発性膝骨壊死に対する骨軟骨柱移植術の治療成績　　　　　　　　　　　　　　　
薮内 康史, 近藤 英司, 小野寺 智洋, 清藤 直樹, 河口 泰之, 小野寺 純, 北村 信人, 安田 和則, 眞島 任史, 笠原 靖彦, 岩崎 倫政, JOSKAS, 40, 4, 561, 561, Jun. 2015
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

当科における膝離断性骨軟骨炎の手術治療成績　　　　　　　　　　　　　　　
西尾 悠介, 笠原 靖彦, 小野寺 智洋, 清藤 直樹, 近藤 英司, 岩崎 倫政, 眞島 任史, JOSKAS, 40, 1, 186, 187, Mar. 2015
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

遺残組織を温存した解剖学的2束前十字靱帯再建術の臨床成績 従来の非温存再建術との比較　　　　　　　　　　　　　　　
近藤 英司, 小野寺 純, 北村 信人, 河口 泰之, 横田 正司, 小野寺 智洋, 清藤 直樹, 岩崎 倫政, 安田 和則, 日本整形外科学会雑誌, 89, 2, S33, S33, Mar. 2015
(公社)日本整形外科学会, Japanese

特発性大腿骨頭壊死症患者のTHA術後満足度は可動域に影響される JHEQとJOA scoreを用いての検討　　　　　　　　　　　　　　　
入江 徹, 高橋 大介, 浅野 毅, 井上 正弘, 安藤 亮, 紺野 拓也, 新井 隆太, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 89, 2, S161, S161, Mar. 2015
(公社)日本整形外科学会, Japanese

S-ROM THAにおけるZTT II cupライナーの10年以上の長期成績　　　　　　　　　　　　　　　
新井 隆太, 高橋 大介, 入江 徹, 浅野 毅, 紺野 拓也, 小野寺 智洋, 清藤 直樹, 深谷 英昭, 井上 正弘, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 89, 2, S171, S171, Mar. 2015
(公社)日本整形外科学会, Japanese

札幌市におけるDDHスクリーニングと育児法指導の現状　　　　　　　　　　　　　　　
高橋 大介, 入江 徹, 浅野 毅, 井上 正弘, 田辺 明彦, 安藤 亮, 紺野 拓也, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 89, 3, S797, S797, Mar. 2015
(公社)日本整形外科学会, Japanese

人工膝関節置換術術中の前十字靱帯および内側半月板切除はkinematics patternに影響しない　　　　　　　　　　　　　　　
清藤 直樹, 小野寺 智洋, 笠原 靖彦, 西尾 悠介, 近藤 英司, 眞島 任史, 岩崎 倫政, 日本整形外科学会雑誌, 89, 3, S898, S898, Mar. 2015
(公社)日本整形外科学会, Japanese

1C43 Measurement of mechanical properties of chondrocytes from glycosphingolipid knock-out mice with micropipette aspiration
NAKAJIMA Toshiaki, MAEDA Eijiro, MATSUBARA Shinji, MOMMA Daisuke, ONODERA Tomohiro, IWASAKI Norimasa, OHASHI Toshiro, バイオエンジニアリング講演会講演論文集, 2015, 27, 129, 130, 08 Jan. 2015
The Japan Society of Mechanical Engineers, Japanese

大腿骨顆部特発性骨壊死に対する骨軟骨柱移植術の治療成績
薮内康史, 小野寺智洋, 清藤直樹, 高橋大介, 入江徹, 浅野毅, 新井隆太, 中野宏昭, 深谷英昭, 岩崎倫政, 近藤英司, 眞島任史, 笠原靖彦, 北海道整形災害外科学会, 128th, 71, 2015
Japanese

THA術前のJHEQ scoreにおける術後改善度予測因子の検討
下段俊, 入江徹, 高橋大介, 浅野毅, 新井隆太, 亀田敏明, 薮内康史, 小野寺智洋, 近藤英司, 岩崎倫政, 北海道整形災害外科学会, 129th, 54, 2015
Japanese

人工股関節全置換術・人工骨頭置換術術後感染に対する治療とその成績
NAKANO HIROAKI, IRIE TOORU, TAKAHASHI DAISUKE, ASANO TAKESHI, FUKAYA HIDEAKI, ARAI RYUTA, KONNO TAKUYA, INOUE MASAHIRO, ONODERA TOMOHIRO, KONDO EIJI, IWASAKI NORIMASA, 日本人工関節学会プログラム・抄録集, 45th, 356, 2015
Japanese

特発性大腿骨頭壊死症と大腿骨頭軟骨下脆弱性骨折の患者背景の検討
薮内康史, 入江徹, 高橋大介, 浅野毅, 新井隆太, 清藤直樹, 中野宏昭, 深谷英昭, 小野寺智洋, 岩崎倫政, 近藤英司, 北海道整形災害外科学会, 128th, 130, 2015
Japanese

高純度アルギン酸ゲルと多段階分化誘導法を併用したマウスiPS細胞軟骨分化誘導法の確立　　　　　　　　　　　　　　　
本谷和俊, 小野寺智洋, 寺島理代, 門間太輔, 松岡正剛, 馬場力哉, 上徳善太, 松原新史, 宝満健太郎, 岩崎倫政, J. Jpn. Orthop. Assoc., 89, 8, S1730, S1730, 2015
(公社)日本整形外科学会, Japanese

ガングリオシド欠損は軟骨の肥大化を抑制することにより関節軟骨修復を促進する　　　　　　　　　　　　　　　
松岡正剛, 小野寺智洋, 笹沢史生, 門間太輔, 馬場力哉, 本谷和俊, 上徳善太, 松原新史, 宝満健太郎, 岩崎倫政, J. Jpn. Orthop. Assoc., 89, 8, S1710, S1710, 2015
(公社)日本整形外科学会, Japanese

軟骨細胞上の高マンノース型糖鎖構造の減少は軟骨変性を促進する　　　　　　　　　　　　　　　
宝満健太郎, 小野寺智洋, 門間太輔, 松岡正剛, 馬場力哉, 本谷和俊, 松原新史, 上徳善太, 岩崎倫政, J. Jpn. Orthop. Assoc., 89, 8, S1533, S1533, 2015
(公社)日本整形外科学会, Japanese

人工膝関節置換術後の大腿骨コンポーネント後顆の厚みは屈曲拘縮のリスクになりうる　　　　　　　　　　　　　　　
小野寺 智洋, 笠原 靖彦, 高橋 大介, 眞島 任史, 西池 修, 近藤 英司, 安田 和則, 北海道整形災害外科学会雑誌, 56, 1, 61, 62, Dec. 2014
北海道整形災害外科学会, Japanese

当科における膝離断性骨軟骨炎の手術治療成績　　　　　　　　　　　　　　　
西尾 悠介, 笠原 靖彦, 小野寺 智洋, 高橋 大介, 浅野 毅, 新井 隆太, 清藤 直樹, 岩崎 倫政, 近藤 英司, 安田 和則, 眞島 任史, 北海道整形災害外科学会雑誌, 56, 1, 67, 67, Dec. 2014
北海道整形災害外科学会, Japanese

リウマチ性前足部変形の関節破壊評価に対する超音波検査の有用性　　　　　　　　　　　　　　　
小野寺 智洋, 綛村 俊之, 笠原 靖彦, 西尾 悠介, 高橋 大介, 岩崎 倫政, 眞島 任史, 近藤 英司, 安田 和則, 北海道整形災害外科学会雑誌, 56, 1, 78, 78, Dec. 2014
北海道整形災害外科学会, Japanese

リウマチ性前足部変形において外側趾の脱臼は高度関節破壊を示唆する　　　　　　　　　　　　　　　
鈴木 裕貴, 小野寺 智洋, 笠原 靖彦, 高橋 大介, 西尾 悠介, 清藤 直樹, 浅野 毅, 新井 隆太, 岩崎 倫政, 眞島 任史, 近藤 英司, 安田 和則, 北海道整形災害外科学会雑誌, 56, 1, 78, 79, Dec. 2014
北海道整形災害外科学会, Japanese

特発性大腿骨頭壊死症におけるテリパラチドの骨頭圧潰進行抑制効果の検討　　　　　　　　　　　　　　　
新井 隆太, 高橋 大介, 入江 徹, 浅野 毅, 笠原 靖彦, 小野寺 智洋, 清藤 直樹, 岩崎 倫政, 井上 正弘, 紺野 拓也, 西尾 悠介, 近藤 英司, 安田 和則, 眞島 任史, 北海道整形災害外科学会雑誌, 56, 1, 121, 122, Dec. 2014
北海道整形災害外科学会, Japanese

偏心性寛骨臼回転骨切り術による大腿骨頭の遠位化と内方化　　　　　　　　　　　　　　　
入江 徹, 高橋 大介, 浅野 毅, 新井 隆太, 笠原 靖彦, 小野寺 智洋, 清藤 直樹, 岩崎 倫政, 井上 正弘, 紺野 拓也, 西尾 悠介, 近藤 英司, 安田 和則, 眞島 任史, 北海道整形災害外科学会雑誌, 56, 1, 123, 123, Dec. 2014
北海道整形災害外科学会, Japanese

リウマチ性前足部変形に対する切除関節形成術:術後再脱臼関連因子の検討　　　　　　　　　　　　　　　
中野 宏昭, 小野寺 智洋, 清藤 直樹, 深谷 英昭, 新井 隆太, 近藤 英司, 岩崎 倫政, 日本足の外科学会雑誌, 35, 2, S258, S258, Oct. 2014
日本足の外科学会, Japanese

Ilizarov創外固定器を用いた足関節固定術の疾患別検討　　　　　　　　　　　　　　　
深谷 英昭, 小野寺 智洋, 清藤 直樹, 中野 宏昭, 新井 隆太, 高橋 大介, 近藤 英司, 岩崎 倫政, 日本足の外科学会雑誌, 35, 2, S280, S280, Oct. 2014
日本足の外科学会, Japanese

変形性足関節症とリウマチ性足関節症における鏡視下足関節固定術の臨床成績の比較　　　　　　　　　　　　　　　
小野寺 智洋, 清藤 直樹, 深谷 英昭, 中野 宏昭, 新井 隆太, 藤田 諒, 近藤 英司, 岩崎 倫政, 日本足の外科学会雑誌, 35, 2, S280, S280, Oct. 2014
日本足の外科学会, Japanese

足趾腫瘍による腫瘍性骨軟化症の1例　　　　　　　　　　　　　　　
新井 隆太, 小野寺 智洋, 高橋 大介, 入江 徹, 浅野 毅, 清藤 直樹, 中野 宏昭, 深谷 英昭, 近藤 英司, 岩崎 倫政, 日本足の外科学会雑誌, 35, 2, S299, S299, Oct. 2014
日本足の外科学会, Japanese

偏心性寛骨臼回転骨切り術による大腿骨頭の遠位化と内方化　　　　　　　　　　　　　　　
入江 徹, 高橋 大介, 井上 正弘, 浅野 毅, 新井 隆太, 安藤 亮, 紺野 拓也, 小野寺 智洋, 近藤 英司, 岩崎 倫政, 東日本整形災害外科学会雑誌, 26, 3, 267, 267, Aug. 2014
東日本整形災害外科学会, Japanese

TKA術中のACL・半月板切除はkinematics patternに影響しない　　　　　　　　　　　　　　　
清藤 直樹, 小野寺 智洋, 笠原 靖彦, 西尾 悠介, 近藤 英司, 眞島 任史, 岩崎 倫政, 日本整形外科学会雑誌, 88, 8, S1499, S1499, Aug. 2014
(公社)日本整形外科学会, Japanese

大腿骨転子間彎曲内反骨切り術における脚短縮理論モデルとその評価　　　　　　　　　　　　　　　
浅野 毅, 高橋 大介, 新井 隆太, 笠原 靖彦, 小野寺 智洋, 近藤 英司, 清藤 直樹, 岩崎 倫政, 日本整形外科学会雑誌, 88, 8, S1542, S1542, Aug. 2014
(公社)日本整形外科学会, Japanese

リウマチ性足関節症に対する鏡視下足関節固定術の治療成績　　　　　　　　　　　　　　　
小野寺 智洋, 藤田 諒, 笠原 靖彦, 清藤 直樹, 近藤 英司, 岩崎 倫政, JOSKAS, 39, 4, 359, 359, Jul. 2014
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

膝関節複合靱帯損傷後内側型OAに対して脛骨骨切り術を施行した1例　　　　　　　　　　　　　　　
清藤 直樹, 小野寺 智洋, 笠原 靖彦, 近藤 英司, 岩崎 倫政, 眞島 任史, JOSKAS, 39, 4, 425, 425, Jul. 2014
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

当科における膝離断性骨軟骨炎の手術治療成績　　　　　　　　　　　　　　　
西尾 悠介, 笠原 靖彦, 小野寺 智洋, 高橋 大介, 浅野 毅, 清藤 直樹, 新井 隆太, 近藤 英司, 岩崎 倫政, 眞島 任史, JOSKAS, 39, 4, 496, 496, Jul. 2014
(一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese

関節リウマチ患者の後足部変形に対する鏡視下足関節固定術の短期成績　　　　　　　　　　　　　　　
藤田 諒, 小野寺 智洋, 笠原 靖彦, 高橋 大介, 清藤 直樹, 浅野 毅, 新井 隆太, 近藤 英司, 岩崎 倫政, 北海道医学雑誌, 89, 1, 90, 90, May 2014
北海道医学会, Japanese

TKA後の膝関節kinematicsは術前のkinematicsに依存する　　　　　　　　　　　　　　　
清藤 直樹, 笠原 靖彦, 小野寺 智洋, 西尾 悠介, 高橋 大介, 浅野 毅, 新井 隆太, 近藤 英司, 眞島 任史, 岩崎 倫政, 日本整形外科学会雑誌, 88, 2, S60, S60, Mar. 2014
(公社)日本整形外科学会, Japanese

人工膝関節置換術において大腿骨顆部と脛骨後縁との相対的位置関係は伸展可動域と相関する　　　　　　　　　　　　　　　
小野寺 智洋, 笠原 靖彦, 西尾 悠介, 清藤 直樹, 近藤 英司, 高橋 大介, 岩崎 倫政, 眞島 任史, 日本整形外科学会雑誌, 88, 2, S62, S62, Mar. 2014
(公社)日本整形外科学会, Japanese

偏心性寛骨臼回転骨切り術による大腿骨頭の遠位化と内方化　　　　　　　　　　　　　　　
入江 徹, 高橋 大介, 井上 正弘, 紺野 拓也, 浅野 毅, 新井 隆太, 笠原 靖彦, 小野寺 智洋, 近藤 英司, 眞島 任史, 岩崎 倫政, 日本整形外科学会雑誌, 88, 2, S257, S257, Mar. 2014
(公社)日本整形外科学会, Japanese

大腿骨顆部特発性骨壊死に対する骨軟骨柱移植術の中〜長期成績　　　　　　　　　　　　　　　
笠原 靖彦, 小野寺 智洋, 西尾 悠介, 清藤 直樹, 高橋 大介, 近藤 英司, 岩崎 倫政, 眞島 任史, 日本整形外科学会雑誌, 88, 2, S294, S294, Mar. 2014
(公社)日本整形外科学会, Japanese

当科における膝離断性骨軟骨炎の手術治療成績　　　　　　　　　　　　　　　
西尾 悠介, 笠原 靖彦, 小野寺 智洋, 高橋 大介, 浅野 毅, 新井 隆太, 清藤 直樹, 近藤 英司, 安田 和則, 眞島 任史, 岩崎 倫政, 日本整形外科学会雑誌, 88, 2, S298, S298, Mar. 2014
(公社)日本整形外科学会, Japanese

テリパラチドは特発性大腿骨頭壊死症の骨頭圧潰進行を抑制する　　　　　　　　　　　　　　　
新井 隆太, 高橋 大介, 井上 正弘, 入江 徹, 紺野 拓也, 浅野 毅, 笠原 靖彦, 小野寺 智洋, 清藤 直樹, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 88, 3, S633, S633, Mar. 2014
(公社)日本整形外科学会, Japanese

人工膝関節インプラントにおいてposterior condylar offsetと脛骨後縁との相対的位置関係は屈曲拘縮のリスクになりうる　　　　　　　　　　　　　　　
小野寺 智洋, 笠原 靖彦, 西池 修, 西尾 悠介, 清藤 直樹, 高橋 大介, 近藤 英司, 岩崎 倫政, 眞島 任史, 日本整形外科学会雑誌, 88, 3, S844, S844, Mar. 2014
(公社)日本整形外科学会, Japanese

人工股関節置換術後のJHEQとJOA scoreの比較検討　　　　　　　　　　　　　　　
太田 昌博, 高橋 大介, 浅野 毅, 辻本 武尊, 小野寺 智洋, 笠原 靖彦, 近藤 英司, 岩崎 倫政, 日本整形外科学会雑誌, 88, 3, S963, S963, Mar. 2014
(公社)日本整形外科学会, Japanese

遺残組織温存解剖学的2束前十字靱帯再建術の臨床成績 連続した161例による非温存再建との前向き比較研究　　　　　　　　　　　　　　　
小野寺 純, 近藤 英司, 北村 信人, 河口 泰之, 横田 正司, 西尾 悠介, 笠原 靖彦, 小野寺 智洋, 岩崎 倫政, 安田 和則, 日本整形外科学会雑誌, 88, 3, S1003, S1003, Mar. 2014
(公社)日本整形外科学会, Japanese

外傷性膝関節脱臼後の内反膝の1例　　　　　　　　　　　　　　　
清藤 直樹, 笠原 靖彦, 小野寺 智洋, 高橋 大介, 浅野 毅, 新井 隆太, 西尾 悠介, 近藤 英司, 眞島 任史, 北海道整形災害外科学会雑誌, 55, 2, 372, 372, Mar. 2014
北海道整形災害外科学会, Japanese

スフィンゴ糖脂質の欠損は変形性関節症の進行を助長する
清藤直樹, 山下匡, 佃幸憲, 松井雄一郎, 瓜田淳, 小野寺智洋, 藤谷直樹, 篠原康郎, 三浪明男, 岩崎倫政, 日本軟骨代謝学会プログラム・抄録集, 27th, 78, 2014
Japanese

側臥位OCM approachの安定したインプラント設置における術前ガイドワイヤー使用の有用性
浅野 毅, 髙橋 大介, 入江 徹, 紺野 拓也, 新井 隆太, 近藤 英司, 笠原 靖彦, 小野寺 智洋, 西尾 悠介, 岩崎 倫政, 日本人工関節学会プログラム・抄録集, 44th, 423, 2014
Japanese, Summary national conference

4ケ月健診はDDHスクリーニングに適切な時期なのか?
髙橋 大介, 浅野 毅, 井上 正弘, 入江 徹, 紺野 拓也, 新井 隆太, 西尾 悠介, 小野寺 智洋, 笠原 靖彦, 近藤 英司, 岩崎 倫政, 北海道整形災害外科学会, 126th, 60, 2014
Japanese, Summary national conference

当科における単顆型人工膝関節置換術の短期成績―New Knee Society Scoreを用いて―
笠原 靖彦, 小野寺 智洋, 西尾 悠介, 清藤 直樹, 髙橋 大介, 浅野 毅, 新井 隆太, 近藤 英司, 岩崎 倫政, 眞島 任史, 日本人工関節学会プログラム・抄録集, 44th, 523, 2014
Japanese, Summary national conference

TKA後のkinematicsと術後の臨床成績の関係
西尾 悠介, 笠原 靖彦, 小野寺 智洋, 髙橋 大介, 浅野 毅, 清藤 直樹, 新井 隆太, 近藤 英司, 岩崎 倫政, 眞島 任史, 日本人工関節学会プログラム・抄録集, 44th, 383, 2014

S​‐​R​O​M​ ​T​H​A​に​お​け​る​Z​T​T​ ​I​I​ ​c​u​p​ラ​イ​ナ​ー​の​長​期​成​績
新井 隆太, 髙橋 大介, 井上 正弘, 入江 徹, 紺野 拓也, 浅野 毅, 笠原 靖彦, 小野寺 智洋, 清藤 直樹, 西尾 悠介, 近藤 英司, 安田 和則, 眞島 任史, 岩崎 倫政, 北海道整形災害外科学会, 126th, 72, 2014
Japanese, Summary national conference

偽関節になった足舟状骨疲労骨折に対する治療経験 1例報告　　　　　　　　　　　　　　　
内田 淳, 安藤 亮, 松原 新史, 門司 順一, 小野寺 智洋, 大西 貴士, 日本足の外科学会雑誌, 34, 2, S344, S344, Oct. 2013
日本足の外科学会, Japanese

当科における膝離断性骨軟骨炎の手術治療成績　　　　　　　　　　　　　　　
西尾 悠介, 笠原 靖彦, 小野寺 智洋, 高橋 大介, 浅野 毅, 新井 隆太, 清藤 直樹, 近藤 英司, 安田 和則, 岩崎 倫政, 眞島 任史, 日本臨床スポーツ医学会誌, 21, 4, S245, S245, Oct. 2013
(一社)日本臨床スポーツ医学会, Japanese

外反母趾における第1TMT関節外転不安定性の検討　　　　　　　　　　　　　　　
小野寺 智洋, 笠原 靖彦, 山崎 修司, 門司 順一, 岩崎 倫政, 近藤 英司, 安田 和則, 眞島 任史, 日本足の外科学会雑誌, 34, 2, S183, S183, Oct. 2013
日本足の外科学会, Japanese

リウマチ性前足部変形において外側趾の脱臼は高度関節破壊を示唆する　　　　　　　　　　　　　　　
鈴木 裕貴, 小野寺 智洋, 笠原 靖彦, 西尾 悠介, 清藤 直樹, 岩崎 倫政, 近藤 英司, 安田 和則, 眞島 任史, 日本足の外科学会雑誌, 34, 2, S207, S207, Oct. 2013
日本足の外科学会, Japanese

膝屈筋腱を用いた解剖学的2束前十字靱帯再建術後の骨孔径変化 CTを用いた研究　　　　　　　　　　　　　　　
近藤 英司, 河口 泰之, 小野寺 純, 北村 信人, 小野寺 智洋, 笠原 靖彦, 高橋 大介, 岩崎 倫政, 安田 和則, 東日本整形災害外科学会雑誌, 25, 3, 360, 360, Aug. 2013
東日本整形災害外科学会, Japanese

A retrospective study of two-stage reimplantation of infected total knee arthroplasty
辻本 武尊, 笠原 靖彦, 小野寺 智洋, 整形・災害外科, 56, 9, 1185, 1191, Aug. 2013
金原出版, Japanese

Risk of deep venous thrombosis in drain clamping with tranexamic acid and carbazochrome sodium sulfonate hydrate in total knee arthroplasty
小野寺 智洋, 整形外科 = Orthopedic surgery, 64, 6, 589, 591, Jun. 2013
南江堂, Japanese

Clinical result of total capsulosynovectomy for pigmented villonodular synovitis of the knee joint
MENJO Yusuke, JOSKAS, 38, 2, 318, 319, 25 Apr. 2013
Japanese

Reconstruction of patellar tendon rupture after anterior cruciate ligament reconstruction : A case report
FUJITA Katsuhisa, JOSKAS, 38, 2, 314, 315, 25 Apr. 2013
Japanese

Clinical and radiological outcome of total knee arthroplasty of severe varus defomity
IWASAKI Koji, JOSKAS, 38, 2, 230, 231, 25 Apr. 2013
Japanese

Osteochondral transplantation for treatment of osteochondral lesions of the talus
ONODERA Tomohiro, JOSKAS, 38, 1, 146, 147, 25 Mar. 2013
Japanese

リウマチ性前足部変形に対する切除関節形成術 MP関節術後再脱臼関連因子の検討　　　　　　　　　　　　　　　
大西 貴士, 小野寺 智洋, 笠原 靖彦, 入江 徹, 綛村 俊之, 三浪 明男, 眞島 任史, 高橋 大介, 北海道整形災害外科学会雑誌, 54, 2, 330, 331, Mar. 2013
北海道整形災害外科学会, Japanese

Novel injection gel for joint disease
小野寺 智洋, 岩崎 倫政, 五十嵐 達弥, 化學工業, 64, 1, 46, 50, Jan. 2013
小峰工業出版, Japanese

Btbd7/Cleftin regulates cleft formation and branching morphogenesis of epithelial cells
Sakai Takayoshi, Onodera Tomohiro, Journal of Oral Biosciences, 55, 2, 73, 75, 2013
Japanese Association for Oral Biology, English, Book review

リウマチ性前足部変形に対する第1MTP関節固定術、第2-5MTP関節切除形成術における術後予後不良因子の検討　　　　　　　　　　　　　　　
小野寺 智洋, 田辺 明彦, 大西 貴士, 沢口 直弘, 渡部 琢哉, 笠原 靖彦, 高橋 大介, 眞島 任史, 日本関節病学会誌, 31, 3, 371, 371, Oct. 2012
(一社)日本関節病学会, Japanese

スフィンゴ糖脂質の欠損は変形性関節症の進行を助長する
清藤直樹, 山下匡, 佃幸憲, 松井雄一郎, 瓜田淳, 小野寺智洋, 藤谷直樹, 篠原康郎, 三浪明男, 岩崎倫政, 日本整形外科学会雑誌, 86, 8, S1330, 25 Aug. 2012
Japanese

リウマチ性前足部変形に対する第1MTP関節固定術、第2-5MTP関節切除形成術における術後予後不良因子の検討　　　　　　　　　　　　　　　
小野寺 智洋, 田辺 明彦, 大西 貴士, 沢口 直弘, 渡部 琢哉, 笠原 靖彦, 高橋 大介, 三浪 明男, 眞島 任史, 北海道医学雑誌, 87, 4-5, 215, 216, Aug. 2012
北海道医学会, Japanese

ガングリオシドGM3は関節リウマチの発症,進行において重要な役割を担う
佃幸憲, 岩崎倫政, 清藤直樹, 金山剛士, 藤谷直樹, 篠原康郎, 笠原靖彦, 小野寺智洋, 浅野毅, 三浪明男, 山下匡, 日本整形外科学会雑誌, 86, 8, 2012

変形性関節症におけるスフィンゴ糖脂質の機能解析
清藤直樹, 岩崎倫政, 佃幸憲, 松井雄一郎, 瓜田淳, 小野寺智洋, 三浪明男, 山下匡, 藤谷直樹, 篠原康郎, 北海道整形災害外科学会, 122nd, 1, 2012
Japanese

マウスにおけるスフィンゴ糖脂質の欠損は変形性関節症の進行を助長する
清藤直樹, 山下匡, 佃幸憲, 松井雄一郎, 瓜田淳, 小野寺智洋, 藤谷直樹, 篠原康郎, 三浪明男, 岩崎倫政, 日本軟骨代謝学会プログラム・抄録集, 25th, 107, 2012
Japanese

ガングリオシドGM3は関節リウマチの発症,進行において重要な役割を担う。
佃幸憲, 岩崎倫政, 清藤直樹, 笠原靖彦, 小野寺智洋, 浅野毅, 三浪明男, 金山剛士, 藤谷直樹, 篠原康郎, 鈴木孝治, 山下匡, 北海道整形災害外科学会, 122nd, 1, 2012
Japanese

Laboratory monitoring of anticoagulant inhibitor of factor Xa with an anti-factor Xa assay
ONODERA Tomohiro, MAJIMA Tokifumi, KASAHARA Yasuhiko, MATSUNO Kazuhiko, ENMI Mari, MINAMI Akio, 東日本整形災害外科学会雑誌 = Journal of the Eastern Japan Association of Orthopaedics and Traumatology, 23, 2, 258, 262, 30 Jun. 2011
Japanese

Cleftin: A novel fibronectin-induced gene that promotes branching morphogenesis
Tomohiro Onodera, Takayoshi Sakai, Kenneth M. Yamada, DEVELOPMENTAL BIOLOGY, 319, 2, 505, 505, Jul. 2008
English, Summary international conference

明日の足診療シリーズⅡ 足の腫瘍性病変・小児疾患の診かた　　　　　　　　　　　　　　　
小野寺智洋, 巻き趾、第Ⅱ章 第10節, 301-304
2021, [Contributor]

整形外科で起こるトラブルと求められる足場材料　　　　　　　　　　　　　　　
小野寺智洋, 第2章 第10 節, 生体吸収性材料の開発と安全性評価, 134-137
技術情報協会, 2017, [Contributor]

関節リウマチの画像診断　　　　　　　　　　　　　　　
小野寺智洋, 進行期関節リウマチ 下肢, 136-158
メディカル・サイエンス・インターナショナル, 2017, [Contributor]

Processing and applications
Manabu Ito, Tomohiro Onodera, Tadanao Funakoshi
Springer, 2015, 9783662468418, x, 281 p., English, [Contributor]

整形外科で起こるトラブルと求められる足場材料　　　　　　　　　　　　　　　
小野寺智洋, 第1章 第5節, 体内埋め込み医療材料の開発とその理想的な性能・デザインの要件, 99-101
技術情報協会, 2013, [Contributor]

Current protocols in cell biology
Tomohiro Onodera, Embryonic organ culture,
John Wiley, 1998, 0471241083, v. (looseleaf), English, [Contributor]

Physician-initiated clinical trials to investigate the safety and durability of an innovative MRI-based modality for the early diagnosis of articular cartilage lesions using O-17- labeled water.　　　　　　　　　　　　　　　
日本医療研究開発機構 令和6年度 「橋渡し研究プログラム」シーズC(a)
Apr. 2024 - Mar. 2028
Principal investigator

機能性糖脂質分子を導入した新規軟骨再生材料の開発
科学研究費助成事業
28 Feb. 2024 - 31 Mar. 2025
小野寺 智洋
日本学術振興会, 基盤研究(B), 北海道大学, 23K25171

Development of Novel Cartilage Regeneration Materials with Functional Glycolipid Molecules
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
01 Apr. 2022 - 31 Mar. 2025
小野寺 智洋, 長濱 宏治, 照川 アラー, 花松 久寿, 松岡 正剛
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 22H03917

Development of in vivo tissue engineering technology utilizing cell cross-linked hydrogel systems
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
01 Apr. 2022 - 31 Mar. 2025
長濱 宏治, 小野寺 智洋
ヒト筋衛星細胞をアジド化マンノサミン存在下で2日間培養してアジド化筋衛星細胞を作製した後、複数のジベンゾシクロオクチン基 (DBCO) を導入した直鎖型アルギン酸とクリック架橋反応させることで筋衛星細胞ゲルを作製した。各種筋衛星細胞架橋ゲルおよびコントロールの筋衛星細胞内包ゲル（筋衛星細胞がアルギン酸が連結していない）に対して、10％のひずみが生じるように10分間だけ圧縮刺激を与えて核の形態変化を評価した結果、細胞架橋ゲル内の細胞核は大きく歪んで扁平化したが、細胞内包ゲルでは核扁平化は起こらなかったことより、細胞架橋ゲルでは与えたメカノシグナルが力学伝導体であるアルギン酸を介してゲル内の細胞に伝わり、細胞が受けたメカノシグナルがそのまま核に伝わり核が扁平化したと考えられる。骨格筋組織で発生する伸展刺激をin vitroで再現する伸展培養装置を用いて、筋衛星細胞架橋ゲルおよび内包ゲルを培養し、分化にかかる転写共役因子YAPの核内移行および筋分化について評価した。その結果、細胞架橋ゲルではYAPの核内移行が短時間で促進されたが、細胞内包ゲルではYAPの核内移行は見られなかった。以上の結果より、筋衛星細胞架橋ゲルでは、筋衛星細胞がメカノシグナルを生化学シグナルにトランスデュースするのではなく、メカノシグナルのままダイレクトに且つ素早く核に伝達することができることが分かった。大腿筋損傷マウスに筋衛星細胞架橋ゲルおよび細胞内包ゲルを投与し、筋力の変化および再建部位の組織学的評価を行った結果、細胞架橋ゲルでは元の筋力レベルまで回復が見られ、再建組織の大部分は筋線維であったが、細胞内包ゲルではほとんど筋力は回復せず、また線維化した組織が再建された。以上の動物実験はin vitro実験で得た知見と一致しており、力学刺激を活用することの意義を実証できた。
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Konan University, 22H03961

O-17標識水を水トレーサーとして用いたMRIによる関節軟骨病変の早期診断を可能とする革新的評価法の確立と治験に向けた実用化研究　　　　　　　　　　　　　　　
日本医療研究開発機構(AMED) 革新的医療技術創出拠点プロジェクト橋渡し研究プログラムpreF
Apr. 2022 - Mar. 2024
Principal investigator, PJ6323KD93

Search for lipid differentiation markers for safe cartilage regenerative medicine using stem cells and elucidate their functions
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
01 Apr. 2018 - 31 Mar. 2022
BABA RIKIYA
In this study, we focused on the fact that the surface of undifferentiated iPS cells were coated with specific glycoconjugates and GSL glycans, we established a method to detect and quantify undifferentiated iPS cells in chondrocytes using cell-specific GSL-glycan analysis by applying the Aminolysis-SALSA method.
Using quantification method by glycan analysis, we could determine the optimal conditions for use of R-17F antibody, which recognizes specific glycans of iPS cells and has cytotoxic activity. Furthermore, we transplanted the antibody-treated co-cultured cells into SCID mice and showed that no teratoma was formed.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 18K09090

外傷性膝関節軟骨損傷に対するO 17 標識水を用いた新たな質的評価法の確立　　　　　　　　　　　　　　　
JA 共済交通事故医療研究助成
Apr. 2020 - Mar. 2022
Principal investigator

Drug development using a novel immune network analysis method for osteoarthritis
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)
Jun. 2017 - Mar. 2020
Onodera Tomohiro
A co-culture model system, including cartilage fragments, macrophages, chondrocytes and synovial cells, to simulate the osteoarthritis joint was established. Regarding cartilage fragments, we successfully created cartilage fragments similar in size to that seen in human osteoarthritis. When we observed the cell dynamics of chondrocytes and synovial cells in our original model, we could observe statistically significant changes in the expression of 153 genes. Currently, among these candidate genes, we are conducting functional analysis on the final candidate gene, which is thought to be particularly related to osteoarthritis.
Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Research (Exploratory), Hokkaido University, Principal investigator, Competitive research funding, 17K19707

Elucidation of pathophysiology of joint disease based on analysis of glycosphingolipid function and development of novel treatment
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
01 Apr. 2016 - 31 Mar. 2019
Iwasaki Norimasa
We aimed to elucidate the molecular mechanisms of glycosphingolipids (GSLs) on chondrocytes involved in the development of osteoarthritis (OA) and to apply them to clinical treatment. In this project, various GSLs-related synthetase gene knockout mice (KO mice) are used to analyze the signal control function of each GSLs molecule against to IL-1 stimulation, and each of the GSLs existing upstream to downstream of GSLs biosynthetic pathway has been shown to be involved in the onset of OA. Moreover, we have clarified that severe OA develops when KO of GSLs molecule located more upstream. In addition, we have demonstrated that GSLs molecules have the function of controlling the transduction of stimulation into cells via Ca channels in response to mechanical stimulation on chondrocytes.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 16H05444

Functional analysis of cartilage glycans for the elucidation of osteoarthritis pathomechanisms
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
01 Apr. 2016 - 31 Mar. 2018
Iwasaki Norimasa, HOMAN Kentaro
Our hypothesis was that early osteoarthritic cahnges induced by alterations in cartilage glycans would be reversible. To test this hypothesis, we created in vivo and in vitro early osteoarthritic models based on alpha-mannosidase administration. The administration of alpha-mannosidase induced early osteoarthritis in in vivo and in vitro models. Additionally, this histological changes were recovered by the discontinuation of alpha-mannosidase adminiatrations. Future studies will be performed to clarify this recovery mechanism in early osteoarthritis pathogenesis.
Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 16K15650

Three-dimensional gait analysis using Anti-gravity treadmill after total hip replacement
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
01 Apr. 2015 - 31 Mar. 2018
TOHRU IRIE
We evaluated the three-dimensional gait analysis of patients who underwent total hip replacement for osteoarthritis under conditions of 50% load, 75% load, 100% load using anti-gravity treadmill. We performed the measurement preoperatively, 3 weeks postoperatively, 6 weeks postoperatively.
At 3 weeks postoperatively, the maximum knee joint extension angle at 50% load significantly increased compared to 100% load. At 6 weeks postoperatively, the maximum hip joint flexion angle at 50% load significantly decreased compared to 100% load and the maximum knee joint extension angle at 50% load significantly increased compared to 100% load.
The current study suggested that the rehabilitation using an anti-gravity treadmill may be effective especially at preoperatively to 3 weeks postoperatively and that this is more effective to maintain the load amount up to 75% load.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 15K10382

Chondroprotective effects of high-molecular-weight cross-linked hyaluronic acid in a rabbit knee osteoarthritis model.
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
01 Apr. 2014 - 31 Mar. 2017
Funakoshi Tadanao
Effect of hyaluronic acid (HA) for osteoarthritis is still controversial. We examined the histopathological changes and the friction coefficient in osteoarthritic knee joint after different molecular weight HA injection (low molecular weight HA, 0.8x106 Da or Ultra-high molecular weight, 6x106 Da) using a rabbit osteoarthritis model. Macroscopic findings showed that severe damaged cartilage was observed in 10% of Ultra-high molecular weight HA and 30% of low molecular weight HA and NS. The histological score and the friction coefficient value of Ultra-high molecular weight HA group were significantly lower than those of the control group (P < 0.05). Ultra-high molecular weight HA has potential chondroprotective effects and superior fiction coefficient. These factors would contribute to prevent progression of osteoarthritis. Intrajoint alteration of molecular weight HA should be clarified in future study.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 26462226

Identification of functional glyco-biomarkers during chondrogenesis of mouse iPS cells
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
01 Apr. 2014 - 31 Mar. 2016
Iwasaki Norimasa, ONODERA Tomohiro
Alterations in the structure of stem cell surface glycoforms were found during chondrogenesis. Based on the obtained results, several glycans are considered to play important roles in stem cell-derived chondrogenesis. The identified glycans have functional potential of chondrogenic biomarkers for the safety of cartilage regenerative medicine.
Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 26670652

骨軟骨修復過程におけるスフィンゴ糖脂質の機能解析　　　　　　　　　　　　　　　
金原一郎記念医学医療振興財団研究助成
Apr. 2015 - Mar. 2016
Principal investigator

Functional role of Syndecan-4 in the process of osteochondral repair
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
2014 - 2016
ONODERA TOMOHORO
We successfully developed novel osteochondral repair model by using young C57Bl/6 mice（Matsuoka M, Onodera T et al., Tissue Eng. 2015）。This novel animal model made us to clarify the cartilage repair mechanisms in glycosphingolipid depletion mice（Matsuoka M, Onodera T et al., Sci Rep. 2017）。In addition, we applied this animal model to Syndecan-4 knockout mice. Surprisingly, osteochondral repair in Syndecan-4 knockout mice is enhanced compare with wildtype mice.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Principal investigator, Competitive research funding, 26462257

関節軟骨再生を目指した骨軟骨修復機構の解明　　　　　　　　　　　　　　　
整形災害外科学研究助成財団研究助成
Apr. 2013 - Mar. 2014

人工膝関節置換術における関節可動域を改善可能な可変型インサートの開発　　　　　　　　　　　　　　　
ノーステック財団 若手研究人材・ネットワーク育成補助金
Apr. 2012 - Mar. 2013
Principal investigator

Functional analysis of glycosphingolipids in osteochondral homeostasis using knockout mice
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
2012 - 2013
IWASAKI Norimasa, TAKAHATA Masahiko, ONODERA Tomohiro
Glycosphingolipids (GSLs) are ubiquitous membrane components that modulate transmembrane signaling and mediate cell-to-cell and cell-to-matrix interactions. The purpose of this study was to clarify the functional roles of GSLs in maintaining osteochondral homeostasis using different strains of GSLs synthase knockout (KO) mice. Although all strains of KO mice developed and grew normally, osteoarthritic changes were dramatically enhanced with aging. IL-1 stimulation of chondrocytes from KO mice significantly increased MMP-13 mRNA expression and apoptosis. In addition, KO mice delayed enchondral ossification during fracture repair process. These findings indicate that GSLs have a chondro-/osteo- protective role and prevent disease progression, although GSLs are not essential for osteochondral tissue development in young mice.
Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, Coinvestigator not use grants, Competitive research funding, 24659661

Functional analysis of Btbd7 in limb formation and chondrogenesis
Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
2011 - 2011
ONODERA Tomohiro
We hypothesized that Gene expression of Btbd7 has an important role in limb formation and chondrogenesis. Chondrogenic differentiation model of mouse chondrocyte progenitor cell revealed that Btbd7, Snail2, and chemokine SDF-1 showed same expression pattern. These genes were transiently upregulated in chondrogenesis process. Therefore, we have driven forward our study focusing on SDF-1. We revealed that SDF-1 was transiently expressed in healing process of cartilage in vivo. In addition, we clarified that chondrogenesis was promoted by using alginate gel with SDF-1.
Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, Principal investigator, Competitive research funding, 23791622