Ueda Kayo
| Faculty of Medicine Social Medicine Social Medicine | Professor |
| Arctic Research Center | Professor |
| Center for Natural Hazards Research | Professor |
Last Updated :2025/06/07
■Researcher basic information
Degree
Profile Information
Dr. Kayo Ueda is Professor in Graduate School of Medicine in Hokkaido University, Japan. She started her working career as a clinician in the treatment of cardiovascular and respiratory diseases. After she changed her career as an environmental epidemiologist, she was engaged with studies clarifying the health effects of particulate air pollution and accumulated the evidence in Japan which contributed to environmental policy making. Currently, her works are to characterize human health risks from atmospheric environment including air pollutants and climate change in Asian countries as well as Japan. She has also been involved with multi-disciplinary research projects.
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Educational Organization
- Bachelor's degree program, Departments of Medicine, School of Medicine
- Master's degree program, Graduate School of Medicine
- Doctoral (PhD) degree program, Graduate School of Medicine
■Career
Career
- Oct. 2021 - Present
Graduate School of Medicine, Hokkaido University, Department of Hygiene, Social Medicine, Professor - Apr. 2018 - Mar. 2021
Kyoto Univeresity, Graduate School of Global Environmental Sciences, Associate Professor - Apr. 2014 - Mar. 2021
Graduate School of Engineering, Kyoto University, Department of Environmental Engineering, Associate Professor - Apr. 2013 - Mar. 2014
National Institute for Environmental Studies, Center for Environmental Health Research, Senior Researcher - Apr. 2008 - Mar. 2013
National Institute for Environmental Studies, 環境健康研究領域, Researcher - Aug. 2006 - Mar. 2008
Yamaguchi University, Graduate School of Medicine, Assistant Professor
Committee Memberships
- 2018 - Present
Japanese Society of Public Health, Editorial Committee Member, Society - Dec. 2017 - Present
Ministry of Environment, Expert Committee on Health Risk Assessment of Hazardous Air Pollutants, Air Noise and Vibration Subcommittee, Central Environment Council, Government - 2017 - Present
Ministry of Environment, Sectorial Working Group on Climate Change Impacts, Government - 2017 - Present
Ministry of Environment, Working Group on Assessment of Health Effects of Photochemical Oxidants, Government - 2017 - Present
Ministry of Environment, Committee for the Evaluation of Health Effects of Photochemical Oxidants, Government - 2017 - Present
環境省, 光化学オキシダント健康リスク解析手法検討作業部会, Government - 2015 - Present
文部科学省, Subcommittee for Promotion of Earth Observation, Subcommittee for Research Planning and Evaluation, Council for Science, Technology and Science, Government - 2011 - Present
環境省, 微小粒子状物資等疫学調査実施班委員, Government - 2010 - Present
環境省, 黄砂の健康影響に関する疫学研究等を行うWG委員, Government - 2017 - 2019
Japanese Society of Atmospheric Environment, Editorial Committee member of Asian Journal of Atmospheric Environment, Society
■Research activity information
Papers
- All-Cause and Cause-Specific Mortality Associated with Long-Term Exposure to Fine Particulate Matter in Japan: The Ibaraki Prefectural Health Study
Takehiro Michikawa, Yuji Nishiwaki, Keiko Asakura, Tomonori Okamura, Toru Takebayashi, Shuichi Hasegawa, Ai Milojevic, Mihoko Minami, Masataka Taguri, Ayano Takeuchi, Kayo Ueda, Toshimi Sairenchi, Kazumasa Yamagishi, Hiroyasu Iso, Fujiko Irie, Hiroshi Nitta
Journal of Atherosclerosis and Thrombosis, Japan Atherosclerosis Society, 2025
Scientific journal - Particulate Matter and Incident Chronic Kidney Disease in Japan: The Ibaraki Prefectural Health Study (IPHS).
Kei Nagai, Shin Araki, Toshimi Sairenchi, Kayo Ueda, Kazumasa Yamagishi, Masayuki Shima, Kouhei Yamamoto, Hiroyasu Iso, Fujiko Irie
JMA journal, 7, 3, 334, 341, 16 Jul. 2024, [Domestic magazines]
English, Scientific journal, INTRODUCTION: Global health hazards caused by air pollution, such as chronic kidney disease (CKD), have been gaining attention; however, air pollution-associated CKD has not been explored in Japan. METHODS: We examined 77,770 men and women with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 in the Ibaraki Prefecture who participated in annual community-based health checkups from 1993 at 40-75 years old and were followed up through December 2020. The outcome was newly developed kidney dysfunction with eGFR of <60 ml/min/1.73 m2 during follow-up. To assess air pollution, a PM2.5 exposure model was employed to estimate yearly means at 1 × 1-km resolution, converted into means at the municipal level. Hazard modeling was employed to examine PM2.5 concentrations in residential areas as a risk factor for outcomes. RESULTS: Participants were distributed across 23 municipalities in the Ibaraki Prefecture, with PM2.5 concentrations between 16.2 and 33.4 μg/m3 (mean, 22.7 μg/m3) in 1987-1995 as the exposure period. There were 942 newly developed kidney dysfunctions during follow-up. Based on 1987-1995 PM2.5 concentrations as the baseline exposure, the multivariate-adjusted hazard ratio per 10-μg/m3 increase in PM2.5 for newly developed kidney dysfunction was 1.02 (95%CI, 0.80-1.24) in men and 1.19 (95%CI, 0.95-1.44) in women. CONCLUSIONS: Elevated PM2.5 did not represent a significant risk factor for incident CKD in a prefecture in Japan. - The perception of air pollution and its health risk: a scoping review of measures and methods
Zeinab Bahrami, Satomi Sato, Zhesi Yang, Monali Maiti, Paoin Kanawat, Tomohiro Umemura, Kazunari Onishi, Hiroaki Terasaki, Tomoki Nakayama, Yutaka Matsumi, Kayo Ueda
Global Health Action, 17, 1, Informa UK Limited, 28 Jun. 2024
Scientific journal - 福岡における越境/局地大気汚染・健康影響に関する研究
髙島久洋, 原圭一郎, 西田千春, 白石浩一, 林政彦, 伊禮聡, 兼保直樹, 高良太, 小林拓, 丸本幸治, 奥田知明, 長田和雄, 乙部直人, 高見昭憲, 内尾英一, 上田佳代, 山崎明宏, 吉野彩子
エアロゾル研究, 39, 2, 129, 144, Jun. 2024, [Peer-reviewed]
Japanese, Scientific journal - Effects of Coexposure to Air Pollution from Vegetation Fires and Extreme Heat on Mortality in Upper Northern Thailand
Athicha Uttajug, Xerxes Seposo, Arthit Phosri, Vera Ling Hui Phung, Muhammad Abdul Basit Ahmad Tajudin, Kayo Ueda
Environmental Science & Technology, American Chemical Society (ACS), 28 May 2024
Scientific journal - Interplay of Climate Change and Air Pollution- Projection of the under-5 mortality attributable to ambient particulate matter (PM2.5) in South Asia
Wahida Musarrat Anita, Athicha Uttajug, Xerxes Tesoro Seposo, Kengo Sudo, Makiko Nakata, Toshihiko Takemura, Hirohisa Takano, Taku Fujiwara, Kayo Ueda
Environmental Research, May 2024
Scientific journal - The effect modification of PM2.5 and ozone on the short-term associations between temperature and mortality across the urban areas of Japan.
Muhammad Abdul Basit Ahmad Tajudin, Ryusei Kubo, Chris Fook Sheng Ng, Masahiro Hashizume, Xerxes Seposo, Yoonhee Kim, Hironori Nishikawa, Hirohisa Takano, Kayo Ueda
Environmental health and preventive medicine, 29, 57, 57, 2024, [Domestic magazines]
English, Scientific journal, BACKGROUND: The acute effects of temperature and air pollution on mortality are well-known environmental factors that have been receiving more recognition lately. However, the health effects resulting from the interaction of air pollution and temperature remain uncertain, particularly in cities with low levels of pollution. This study aims to examine the modification effects of particulate matter with a diameter of 2.5 µm or less (PM2.5) and ozone (O3) on the association between temperature and mortality. METHODS: We collected the daily number of all-cause, cardiovascular, and respiratory mortality from 20 major cities in Japan from 2012-2018. We obtained meteorological data from the Japan Meteorological Agency and air pollution data from the National Institute for Environmental Studies. We conducted analyses using a quasi-Poisson regression model with a distributed lag non-linear model for temperature in each city and subsequently performed a random-effects meta-analysis to derive average estimates. RESULTS: We found that high levels of O3 might positively modify the mortality risk of heat exposure, especially for cardiovascular diseases. Subgroups such as the elderly and females were susceptible. We did not observe consistent evidence of effect modification by PM2.5, including effect modification on cold by both pollutants. CONCLUSION: PM2.5 and O3 may positively modify the short-term association between heat and mortality in the urban areas of Japan. These results highlight the need for public health policies and interventions to address the collective impacts of both temperature and air pollution. - A Nationwide Comparative Analysis of Temperature-Related Mortality and Morbidity in Japan.
Lei Yuan, Lina Madaniyazi, Ana M Vicedo-Cabrera, Yasushi Honda, Chris Fook Sheng Ng, Kayo Ueda, Kazutaka Oka, Aurelio Tobias, Masahiro Hashizume
Environmental health perspectives, 131, 12, 127008, 127008, Dec. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: The impact of temperature on morbidity remains largely unknown. Moreover, extensive evidence indicates contrasting patterns between temperature-mortality and temperature-morbidity associations. A nationwide comparison of the impact of temperature on mortality and morbidity in more specific subgroups is necessary to strengthen understanding and help explore underlying mechanisms by identifying susceptible populations. OBJECTIVE: We performed this study to quantify and compare the impact of temperature on mortality and morbidity in 47 prefectures in Japan. METHODS: We applied a two-stage time-series design with distributed lag nonlinear models and mixed-effect multivariate meta-analysis to assess the association of temperature with mortality and morbidity by causes (all-cause, circulatory, and respiratory) at prefecture and country levels between 2015 and 2019. Subgroup analysis was conducted by sex, age, and regions. RESULTS: The patterns and magnitudes of temperature impacts on morbidity and mortality differed. For all-cause outcomes, cold exhibited larger effects on mortality, and heat showed larger effects on morbidity. At specific temperature percentiles, cold (first percentile) was associated with a higher relative risk (RR) of mortality [1.45; 95% confidence interval (CI): 1.39, 1.52] than morbidity (1.33; 95% CI: 1.26, 1.40), as compared to the minimum mortality/morbidity temperature. Heat (99th percentile) was associated with a higher risk of morbidity (1.30; 95% CI: 1.28, 1.33) than mortality (1.04; 95% CI: 1.02, 1.06). For cause-specific diseases, mortality due to circulatory diseases was more susceptible to heat and cold than morbidity. However, for respiratory diseases, both cold and heat showed higher risks for morbidity than mortality. Subgroup analyses suggested varied associations depending on specific outcomes. DISCUSSION: Distinct patterns were observed for the association of temperature with mortality and morbidity, underlying different mechanisms of temperature on different end points, and the differences in population susceptibility are possible explanations. Future mitigation policies and preventive measures against nonoptimal temperatures should be specific to disease outcomes and targeted at susceptible populations. https://doi.org/10.1289/EHP12854. - Enhancing health resilience in Japan in a changing climate.
Yoonhee Kim, Kazutaka Oka, Erin C Kawazu, Chris Fook Sheng Ng, Xerxes Seposo, Kayo Ueda, Masahiro Hashizume, Yasushi Honda
The Lancet regional health. Western Pacific, 40, 100970, 100970, Nov. 2023, [International Magazine]
English, Scientific journal, Climate change poses significant threats to human health, propelling Japan to take decisive action through the Climate Change Adaptation Act of 2018. This Act has led to the implementation of climate change adaptation policies across various sectors, including healthcare. In this review, we synthesized existing scientific evidence on the impacts of climate change on health in Japan and outlined the adaptation strategies and measures implemented by the central and local governments. The country has prioritized tackling heat-related illness and mortality and undertaken various adaptation measures to mitigate these risks. However, it faces unique challenges due to its super-aged society. Ensuring effective and coordinated strategies to address the growing uncertainties in vulnerability to climate change and the complex intersectoral impacts of disasters remains a critical issue. To combat the additional health risks by climate change, a comprehensive approach embracing adaptation and mitigation policies in the health sector is crucial. Encouraging intersectoral communication and collaboration will be vital for developing coherent and effective strategies to safeguard public health in the face of climate change. - Differential Pattern of Cell Death and ROS Production in Human Airway Epithelial Cells Exposed to Quinones Combined with Heated-PM2.5 and/or Asian Sand Dust
A Honda, KI Inoue, M Higashihara, T Ichinose, K Ueda, H Takano
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24, 13, 10544, Jul. 2023, [Peer-reviewed]
English, Scientific journal - Association between greenness and cardiovascular risk factors: Results from a large cohort study in Thailand.
Kanawat Paoin, Chanathip Pharino, Arthit Phosri, Kayo Ueda, Xerxes Tesoro Seposo, Matthew Kelly, Sam-Ang Seubsman, Adrian Sleigh
Environmental research, 220, 115215, 115215, 01 Mar. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: The risk of cardiovascular diseases may be reduced by residing in green environments. However, there are relatively few longitudinal cohort studies, especially in Southeast Asia, that focused on the health benefits of long-term greenness exposure in young adults. The present study examined the association between long-term exposure to residential greenness and self-reported morbidities in participants of the Thai Cohort Study (TCS) in Thailand from 2005 to 2013. METHODS: The self-reported outcomes, including high blood pressure, high blood cholesterol, and diabetes, were reported in 2005, 2009, and 2013, where the study participants provided the exact year of disease occurrence. Greenness was assessed by the satellite-based Normalized Difference Vegetation Index (NDVI) and Enhanced Vegetation Index (EVI), with a spatial resolution of 250 m. Long-term exposure to NDVI and EVI of each participant's sub-district was averaged over the period of person-time. We used Cox proportional hazards models to examine the association between greenness and health outcomes. Associations with self-reported morbidity were measured using hazard ratios (HRs) per interquartile range (IQR) increase in NDVI and EVI. RESULTS: After adjusting for potential confounders, we observed that an IQR increase in NDVI was associated with lower incidence of high blood pressure (HR = 0.92, 95% CI: 0.89, 0.97) and high blood cholesterol (HR = 0.89, 95%CI: 0.87, 0.92), but not significantly associated with diabetes (HR = 0.93, 95%CI: 0.85, 1.01). EVI was also inversely associated with self-reported high blood pressure (HR = 0.92, 95%CI: 0.88, 0.96), high blood cholesterol (HR = 0.89, 95%CI: 0.87, 0.91), and diabetes (HR = 0.92, 95%CI: 0.85, 0.99). CONCLUSIONS: Long-term exposure to residential greenness was inversely associated with self-reported high blood pressure, high blood cholesterol, and diabetes in participants of TCS. Our study provides evidence that greenness exposure may reduce cardiovascular disease risk factors in adult population. - Effect modification by temperature on the association between O3 and emergency ambulance dispatches in Japan: A multi-city study.
Arthit Phosri, Kayo Ueda, Xerxes Seposo, Akiko Honda, Hirohisa Takano
The Science of the total environment, 861, 160725, 160725, 25 Feb. 2023, [International Magazine]
English, Scientific journal, Numerous epidemiological studies have reported that ozone (O3) and temperature are independently associated with health outcomes, but modification of the effects of O3 on health outcomes by temperature, and vice versa, has not been fully described. This study aimed to investigate effect modification by temperature on the association between O3 and emergency ambulance dispatches (EADs) in Japan. Data on daily air pollutants, ambient temperature, and EADs were obtained from eight Japanese cities from 2007 to 2015. A distributed lag non-linear model combined with Poisson regression was performed with temperature as a confounding factor and effect modifier to estimate the effects of O3 on EADs at low (<25th percentile), moderate (25th-75th percentile), and high (>75th percentile) temperature for each city. The estimates obtained from each city were pooled by random-effects meta-analysis. When temperature was entered as a confounder, the estimated effects of O3 on EADs for all acute, cardiovascular, and respiratory illnesses were largest at lag 0 (current-day lag). Therefore, this lag was used to further estimate the effects of O3 on EADs in each temperature category. The estimated effects of O3 on EADs for all acute, cardiovascular, and respiratory illnesses in all eight Japanese cities increased with increasing temperature. Specifically, a 10 ppb increase in O3 was associated with 0.80 % (95 % CI: 0.25 to 1.35), 0.19 % (95 % CI: -0.85 to 1.25), and 1.14 % (95 % CI: -0.01 to 2.31) increases in the risk of EADs for all acute, cardiovascular, and respiratory illnesses, respectively, when city-specific daily temperature exceeded the 75th percentile. Our findings suggest that the association between O3 and EADs for all acute, cardiovascular, and respiratory illnesses is the highest during high temperature. Finding of this study can be used to develop potential mitigation measures against O3 exposure in high temperature environment to reduce its associated adverse health effects. - Association between Long-Term Ambient PM2.5 Exposure and under-5 Mortality: A Scoping Review.
Wahida Musarrat Anita, Kayo Ueda, Athicha Uttajug, Xerxes Tesoro Seposo, Hirohisa Takano
International journal of environmental research and public health, 20, 4, 13 Feb. 2023, [International Magazine]
English, Scientific journal, Studies have established a link between exposure to fine particles (PM2.5) and mortality in infants and children. However, few studies have explored the association between post-birth exposure to PM2.5 and under-5 mortality. We conducted a scoping review to identify relevant epidemiological evidence on the association between post-birth ambient PM2.5 exposure and under-5 mortality. We searched PubMed and Web of Science for articles published between 1970 and the end of January 2022 that explicitly linked ambient PM2.5 and under-5 mortality by considering the study area, study design, exposure window, and child age. Information was extracted on the study characteristics, exposure assessment and duration, outcomes, and effect estimates/findings. Ultimately, 13 studies on infant and child mortality were selected. Only four studies measured the effect of post-birth exposure to PM2.5 on under-5 mortality. Only one cohort study mentioned a positive association between post-birth ambient PM2.5 exposure and under-5 mortality. The results of this scoping review highlight the need for extensive research in this field, given that long-term exposure to ambient PM2.5 is a major global health risk and child mortality remains high in some countries. - Daily temperature effects on under-five mortality in a tropical climate country and the role of local characteristics.
Vera Ling Hui Phung, Kazutaka Oka, Yasushi Honda, Yasuaki Hijioka, Kayo Ueda, Xerxes Tesoro Seposo, Mazrura Sahani, Wan Rozita Wan Mahiyuddin, Yoonhee Kim
Environmental research, 218, 114988, 114988, 01 Feb. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: Climate change and its subsequent effects on temperature have raised global public health concerns. Although numerous epidemiological studies have shown the adverse health effects of temperature, the association remains unclear for children aged below five years old and those in tropical climate regions. METHODS: We conducted a two-stage time-stratified case-crossover study to examine the association between temperature and under-five mortality, spanning the period from 2014 to 2018 across all six regions in Malaysia. In the first stage, we estimated region-specific temperature-mortality associations using a conditional Poisson regression and distributed lag nonlinear models. We used a multivariate meta-regression model to pool the region-specific estimates and examine the potential role of local characteristics in the association, which includes geographical information, demographics, socioeconomic status, long-term temperature metrics, and healthcare access by region. RESULTS: Temperature in Malaysia ranged from 22 °C to 31 °C, with a mean of 27.6 °C. No clear seasonality was observed in under-five mortality. We found no strong evidence of the association between temperature and under-five mortality, with an "M-" shaped exposure-response curve. The minimum mortality temperature (MMT) was identified at 27.1 °C. Among several local characteristics, only education level and hospital bed rates reduced the residual heterogeneity in the association. However, effect modification by these variables were not significant. CONCLUSION: This study suggests a null association between temperature and under-five mortality in Malaysia, which has a tropical climate. The "M-" shaped pattern suggests that under-fives may be vulnerable to temperature changes, even with a small temperature change in reference to the MMT. However, the weak risks with a large uncertainty at extreme temperatures remained inconclusive. Potential roles of education level and hospital bed rate were statistically inconclusive. - Long-term trends in mortality risk associated with short-term exposure to air pollution in 10 Japanese cities between 1977 and 2015.
Hironori Nishikawa, Xerxes Tesoro Seposo, Lina Madaniyazi, Yoonhee Kim, Aurelio Tobías, Makiko Yamagami, Satbyul Estella Kim, Akinori Takami, Seiji Sugata, Yasushi Honda, Kayo Ueda, Masahiro Hashizume, Chris Fook Sheng Ng
Environmental research, 219, 115108, 115108, 19 Dec. 2022, [International Magazine]
English, Scientific journal, BACKGROUND AND AIM: Short-term associations between air pollution and mortality have been well reported in Japan, but the historical changes in mortality risk remain unknown. We examined temporal changes in the mortality risks associated with short-term exposure to four criteria air pollutants in selected Japanese cities. METHODS: We collected daily mortality data for non-accidental causes (n = 5,748,206), cardiovascular (n = 1,938,743) and respiratory diseases (n = 777,266), and air pollutants (sulfur dioxide [SO2], nitrogen dioxide [NO2], suspended particulate matter [SPM], and oxidants [Ox]) in 10 cities from 1977 to 2015. We performed two-stage analysis with 5-year stratification to estimate the relative risk (RR) of mortality per 10-unit increase in the 2-day moving average of air pollutant concentrations. In the first stage, city-specific associations were assessed using a quasi-Poisson generalized linear regression model. In the second stage, city-specific estimates were pooled using a random-effects meta-analysis. Linear trend and ratio of relative risks (RRR) were computed to examine temporal changes. RESULTS: When stratifying the analysis by every 5 years, average concentrations in each sub-period decreased for SO2, NO2, and SPM (14.2-2.3 ppb, 29.4-17.5 ppb, 52.1-20.6 μg/m3, respectively) but increased for Ox (29.1-39.1 ppb) over the study period. We found evidence of a negative linear trend in the risk of cardiovascular mortality associated with SPM across sub-periods. However, the risks of non-accidental and respiratory mortality per 10-unit increase in SPM concentration were significantly higher in the most recent period than in the earliest period. Other gaseous pollutants did not show such temporal risk change. The risks posed by these pollutants were slightly to moderately heterogeneous in the different cities. CONCLUSIONS: The mortality risks associated with short-term exposure to SPM changed, with different trends by cause of death, in 10 cities over 39 years whereas the risks for other gaseous pollutants were relatively stable. - Effects of Streamer Discharge on PM2.5 Containing Endotoxins and Polyaromatic Hydrocarbons and Their Biological Responses In Vitro.
Akiko Honda, Ken-Ichiro Inoue, Shin Tamura, Michitaka Tanaka, Zaoshi Wang, Toshio Tanaka, Seitarou Hirai, Tomoaki Okuda, Kayo Ueda, Hirohisa Takano
International journal of molecular sciences, 23, 24, 14 Dec. 2022, [International Magazine]
English, Scientific journal, Experimental and epidemiological studies have demonstrated that fine particulate matter with a diameter of <2.5 μm (PM2.5) affects both the respiratory and immune systems. However, effective approaches to reduce PM2.5-induced hazardous effects have not been discovered yet. Streamer discharge is a category of plasma discharge in which high-speed electrons collide with oxygen and nitrogen molecules. Although streamer discharge can reportedly eliminate bacteria, molds, chemical substances, and allergens, its ability to decontaminate PM2.5 has not been previously demonstrated. The present study explored whether streamer discharge treatment could reduce PM2.5-induced inflammatory responses by employing an in vitro system. PM2.5 was collected under four conditions (Bangkok (Sep.−Dec.), Bangkok (Dec.−Mar.), Singapore, and Taipei). Airway epithelial cells and antigen-presenting cells exposed to non-treated PM2.5 in several conditions resulted in inflammatory responses. Streamer-discharged PM2.5 (Bangkok (Sep.−Dec.)) decreased the expression of interleukin (IL)-6 and IL-8 compared to non-treated PM2.5. Moreover, composition analysis demonstrated that streamer discharge reduced some compounds, such as endotoxins and polycyclic aromatic hydrocarbons, included in PM2.5 that can elicit inflammatory responses. Streamer discharge treatment can reduce endotoxins, polycyclic aromatic hydrocarbons, and the subsequent inflammatory responses induced by PM2.5 in vitro. - Role of oxides of nitrogen in the ozone-cardiorespiratory visit association
Xerxes Seposo, Kayo Ueda, Chris Fook Sheng Ng, Lina Madaniyazi, Seiji Sugata, Ayako Yoshino, Akinori Takami
Environmental Pollution, 317, 120802, 120802, Dec. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Ozone (O3)-induced health effects vary in terms of severity, from deterioration of lung function and hospitalization to death. Several studies have reported a linear increase in health risks after O3 exposure. However, current evidence suggests a non-linear U- and J-shaped concentration-response (C-R) function. The potential increasing risks with decreasing O3 concentrations may seem counterintuitive from the traditional standpoint that decreasing exposure should lead to decreasing health risks. Tus, the question of whether the increasing risks with decreasing concentrations are truly O3-induced or might be from other C-R mechanisms. If these potential risks were not accounted for, this may have contributed to the risks observed at the low ozone concentration range. In this study, we examined the short-term effects of photochemical oxidant (Ox, parts per billiion) on outpatient cardiorespiratory visits in 21 Japanese cities after adjusting for other air pollutant-specific C-R functions. Daily cardiorespiratory visits from January 1, 2014 to December 31, 2016 were obtained from the Japanese Medical Data Center Co. Ltd. Similar period of meteorological and air pollution variables were obtained from relevant data sources. We utilized a time-stratified case crossover design coupled with the generalized additive mixed model (TSCC-GAMM) to estimate the association between Ox and cardiorespiratory outpatient visits, after adjusting for several covariates. A total of 2,588,930 visits were recorded across the study period, with a mean of 111.87 and a standard deviation of 138.75. The results revealed that crude Ox-cardiorespiratory visits exhibited a U-shaped pattern. However, adjustment of the oxides of nitrogen, particularly nitrogen monoxide (NO), attenuated the lower risk curve and subsequently altered the shape of the C-R function, with a substantial reduction observed during winter. NO- and nitrogen dioxide (NO2)-adjusted Ox-cardiorespiratory associations increased nearly linearly, without an apparent threshold. Current evidence suggests the importance of adjusting the oxides of nitrogen in estimating the Ox C-R risk functions. - Estimation of hospital visits for respiratory diseases attributable to PM10 from vegetation fire smoke and health impacts of regulatory intervention in Upper Northern Thailand
Athicha Uttajug, Kayo Ueda, Akiko Honda, Hirohisa Takano
Scientific Reports, 12, 1, Springer Science and Business Media LLC, 02 Nov. 2022
Scientific journal, Abstract
The air quality in Upper Northern Thailand (UNT) deteriorates during seasonal vegetation fire events, causing adverse effects especially on respiratory health outcomes. This study aimed to quantitatively estimate respiratory morbidity from vegetation fire smoke exposure, and to assess the impact of a burning ban enforced in 2016 on morbidity burden in UNT. We computed daily population exposure to fire-originated PM10 and estimated its health burden during a 5-year period from 2014 to 2018 using daily fire-originated PM10 concentration and the concentration–response function for short-term exposure to PM10 from vegetation fire smoke and respiratory morbidity. In subgroups classified as children and older adults, the health burden of respiratory morbidity was estimated using specific effect coefficients from previous studies conducted in UNT. Finally, we compared the health burden of respiratory morbidity before and after burning ban enforcement. Approximately 130,000 hospital visits for respiratory diseases were estimated to be attributable to fire-originated PM10 in UNT from 2014 to 2018. This estimation accounted for 1.3% of total hospital visits for respiratory diseases during the 5-year period, and 20% of those during burning events. Age-specific estimates revealed a larger impact of PM10 in the older adult group. The number of hospital visits for respiratory diseases attributable to fire-originated PM10 decreased from 1.8% to 0.5% after the burning ban policy was implemented in the area. Our findings suggest that PM10 released from vegetation fires is a health burden in UNT. The prohibition of the burning using regulatory measure had a positive impact on respiratory morbidity in this area. - Environmental variable importance for under-five mortality in Malaysia: A random forest approach
Vera Ling Hui Phung, Kazutaka Oka, Yasuaki Hijioka, Kayo Ueda, Mazrura Sahani, Wan Rozita Wan Mahiyuddin
Science of The Total Environment, 845, 157312, 157312, Elsevier BV, Nov. 2022
Scientific journal - Effects of Oxidized Pyrenes on the Biological Responses in the Human Bronchial Epithelial Cells
Akiko Honda, Ken-ichiro Inoue, Satsuki Takai, Takayuki Kameda, Kayo Ueda, Hirohisa Takano
APPLIED SCIENCES-BASEL, 12, 19, Oct. 2022
English, Scientific journal - A scoping review on the health effects of smoke haze from vegetation and peatland fires in Southeast Asia: Issues with study approaches and interpretation
Vera Ling Hui Phung, Attica Uttajug, Kayo Ueda, Nina Yulianti, Mohd Talib Latif, Daisuke Naito
PLOS ONE, 17, 9, e0274433, e0274433, Public Library of Science (PLoS), 15 Sep. 2022, [Peer-reviewed]
Scientific journal, Smoke haze due to vegetation and peatland fires in Southeast Asia is a serious public health concern. Several approaches have been applied in previous studies; however, the concepts and interpretations of these approaches are poorly understood. In this scoping review, we addressed issues related to the application of epidemiology (EPI), health burden estimation (HBE), and health risk assessment (HRA) approaches, and discussed the interpretation of findings, and current research gaps. Most studies reported an air quality index exceeding the ‘unhealthy’ level, especially during smoke haze periods. Although smoke haze is a regional issue in Southeast Asia, studies on its related health effects have only been reported from several countries in the region. Each approach revealed increased health effects in a distinct manner: EPI studies reported excess mortality and morbidity during smoke haze compared to non-smoke haze periods; HBE studies estimated approximately 100,000 deaths attributable to smoke haze in the entire Southeast Asia considering all-cause mortality and all age groups, which ranged from 1,064–260,000 for specified mortality cause, age group, study area, and study period; HRA studies quantified potential lifetime cancer and non-cancer risks due to exposure to smoke-related chemicals. Currently, there is a lack of interconnection between these three approaches. The EPI approach requires extensive effort to investigate lifetime health effects, whereas the HRA approach needs to clarify the assumptions in exposure assessments to estimate lifetime health risks. The HBE approach allows the presentation of health impact in different scenarios, however, the risk functions used are derived from EPI studies from other regions. Two recent studies applied a combination of the EPI and HBE approaches to address uncertainty issues due to the selection of risk functions. In conclusion, all approaches revealed potential health risks due to smoke haze. Nonetheless, future studies should consider comparable exposure assessments to allow the integration of the three approaches. - A Case-Crossover Analysis of the Association between Exposure to Total PM2.5 and Its Chemical Components and Emergency Ambulance Dispatches in Tokyo.
Takehiro Michikawa, Junichi Sasaki, Shin Yamazaki, Akinori Takami, Keiko Asakura, Haruhiko Imamura, Kayo Ueda, Shinji Saito, Junya Hoshi, Ayako Yoshino, Seiji Sugata, Hiroshi Nitta, Yuji Nishiwaki
Environmental science & technology, 56, 11, 7319, 7327, 07 Jun. 2022, [International Magazine]
English, Scientific journal, A limited number of studies have investigated the association between short-term exposure to PM2.5 components and morbidity. The present case-crossover study explored the association between exposure to total PM2.5 and its components and emergency ambulance dispatches, which is one of the indicators of morbidity, in the 23 Tokyo wards. Between 2016 and 2018 (mean mass concentrations of total PM2.5 13.5 μg/m3), we obtained data, from the Tokyo Fire Department, on the daily cases of ambulance dispatches. Fine particles were collected at a fixed monitoring site and were analyzed to estimate the daily mean concentrations of carbons and ions. We analyzed 1038301 cases of health-based all-cause ambulance dispatches by using a conditional logistic regression model. The average concentrations of total PM2.5 over one and the previous day were positively associated with the number of ambulance dispatches. In terms of PM2.5 components, the percentage increase per interquartile range (IQR) increase was 0.8% for elemental carbon (IQR = 0.8 μg/m3; 95% CI = 0.3-1.3%), 0.9% for sulfate (2.1 μg/m3; 0.5-1.4%), and 1.1% for ammonium (1.3 μg/m3; 0.4-1.8%) in the PM2.5-adjusted models. This is the first study to find an association between some specific components in PM2.5 and ambulance dispatches. - アレルギーを悪化させるパーソナルケア製品の同定
本田 晶子, 丹 嵯織, 宮坂 奈津子, 雑賀 大輔, 邱 彬洋, 長尾 慧, 李 銀鵬, 王 造時, 石川 良賀, 上田 佳代, 高野 裕久
The Journal of Toxicological Sciences, 47, Suppl., S94, S94, (一社)日本毒性学会, Jun. 2022
Japanese - Application of three-dimensional Raman imaging to determination of the relationship between cellular localization of diesel exhaust particles and the toxicity
Langying Ou, Akiko Honda, Natsuko Miyasaka, Sakiko Akaji, Issei Omori, Raga Ishikawa, Yinpeng Li, Kayo Ueda, Hirohisa Takano
TOXICOLOGY MECHANISMS AND METHODS, 32, 5, 333, 340, Jun. 2022, [Peer-reviewed]
English, Scientific journal - Effect of a vegetation fire event ban on hospital visits for respiratory diseases in Upper Northern Thailand
Athicha Uttajug, Kayo Ueda, Xerxes Tesoro Seposo, Akiko Honda, Hirohisa Takano
International Journal of Epidemiology, Oxford University Press (OUP), 04 Feb. 2022
Scientific journal,Abstract
Background
Upper Northern Thailand (UNT) has been episodically affected by air pollution from vegetation burning, which causes adverse respiratory health effects. However, no study has evaluated the effect of regulatory actions to prohibit vegetation burning on respiratory morbidity. We examined the effect of a burning ban enforced in May 2016 on hospital visits for respiratory diseases in UNT.
Methods
This study used data from eight provinces in UNT. Analyses were conducted for January to April of 2014–2016 (before ban enforcement) and January to April of 2017–2018 (after ban enforcement). Particulate matter of 10 microns in diameter or smaller (PM10) concentrations, numbers of satellite fire hotspots and age-standardized rates of hospital visits for respiratory diseases before and after ban enforcement were compared. The effect of the ban on hospital visits for respiratory diseases was evaluated using an interrupted time-series analysis controlled for season-specific temporal trends, day of week, public holiday, temperature, relative humidity, number of hospitals and offset population, with gastrointestinal diseases as a negative control. A meta-analysis was performed to pool province-specific effect estimates.
Results
The daily average PM10 concentration and the number of fire hotspots decreased after ban enforcement in all provinces in UNT, with percent changes ranging from 5.3 to 34.3% and 14.3 to 81.5%, respectively. The adjusted pooled effect estimates of hospital visits for respiratory diseases decreased by 9.1% (95% CI: 5.1, 12.9), whereas a null association was observed for gastrointestinal diseases.
Conclusion
The burning ban had a positive impact on both air pollution levels and rates of hospital visits for respiratory diseases in UNT.
- Long-term air pollution exposure and decreased kidney function: A longitudinal cohort study in Bangkok Metropolitan Region, Thailand from 2002 to 2012.
Kanawat Paoin, Kayo Ueda, Prin Vathesatogkit, Thammasin Ingviya, Suhaimee Buya, Racha Dejchanchaiwong, Arthit Phosri, Xerxes Tesoro Seposo, Chagriya Kitiyakara, Nisakron Thongmung, Akiko Honda, Hirohisa Takano, Piyamitr Sritara, Perapong Tekasakul
Chemosphere, 287, Pt 1, 132117, 132117, Jan. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: Kidney dysfunction is considered a cardiovascular risk factor. However, few longitudinal studies have examined the effects of air pollution on kidney function. We evaluated associations between long-term air pollution exposure and estimated glomerular filtration rate (eGFR) using data from a cohort of the Electricity Generating Authority of Thailand (EGAT) study in Bangkok Metropolitan Region, Thailand. METHODS: This longitudinal study included 1839 subjects (aged 52-71 years in 2002) from the EGAT1 cohort study during 2002-2012. eGFR, based on creatinine, was measured in 2002, 2007, and 2012. Annual mean concentrations of air pollutants (i.e., particulate matter with an aerodynamic diameter ≤10 μm (PM10), ozone (O3), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO)) prior to a measurement of creatinine were assessed with the ordinary kriging method. Mixed-effect linear regression models were used to assess associations between air pollutants and eGFR, while controlling for potential covariates. eGFR values are expressed as percent change per interquartile range (IQR) increments of each pollutant. RESULTS: Lower eGFR was associated with higher concentrations of PM10 (-1.99%, 95% confidence interval (CI): -3.33, -0.63), SO2 (-4.89%, 95%CI: -6.69, -3.07), and CO (-0.97%, 95%CI: -1.96, 0.03). However, after adjusting for temperature, relative humidity, PM10, and SO2, no significant association was observed between CO and eGFR. CONCLUSIONS: Our findings support the hypothesis that long-term exposure to high concentrations of PM10 and SO2 is associated with the progression of kidney dysfunction in subjects of the EGAT cohort study. - PM2.5の測定法と動態
山神 真紀子, 池盛 文数, 久恒 邦裕, 中島 寛則, 上田 佳代, 若松 伸司, 長田 和雄
大気環境学会誌, 57, 1, A18, A20, (公社)大気環境学会, Jan. 2022
Japanese - ケースクロスオーバーデザインによる微小粒子成分と23区内救急搬送との関連性について
道川 武紘, 佐々木 淳一, 山崎 新, 高見 昭憲, 朝倉 敬子, 今村 晴彦, 上田 佳代, 齊藤 伸治, 星 純也, 吉野 彩子, 菅田 誠治, 新田 裕史, 西脇 祐司
Journal of Epidemiology, 32, Suppl.1, 96, 96, (一社)日本疫学会, Jan. 2022
Japanese - Exposure to PM2.5 and Lung Function Growth in Pre- and Early Adolescent Schoolchildren.
Toru Takebayashi, Masataka Taguri, Hiroshi Odajima, Shuichi Hasegawa, Keiko Asakura, Ai Milojevic, Ayano Takeuchi, Satoshi Konno, Miki Morikawa, Teruomi Tsukahara, Kayo Ueda, Yasufumi Mukai, Mihoko Minami, Yuuji Nishiwaki, Takesumi Yoshimura, Masaharu Nishimura, Hiroshi Nitta
Annals of the American Thoracic Society, 19, 5, 763, 772, 21 Oct. 2021, [International Magazine]
English, Scientific journal, RATIONALE: Epidemiological evidence indicates ambient exposure to PM2.5 have adverse effects on lung function growth in children, but it is not actually clear whether exposure to low level PM2.5 results in long-term decrements in lung function growth in pre- to early adolescent schoolchildren. OBJECTIVES: To examine long-term effects of PM2.5 within the 4-yr concentration range of 10 to 19 μg/m3 on lung function growth with repeated measurements of lung function tests. METHODS: Longitudinal analysis of 6,233 lung function measurements in 1,466 participants aged 8 to 12 from 16 school communities in 10 cities around Japan, covering a board area of the country to represent concentration range of PM2.5, was done with multilevel linear regression model. Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and maximal expiratory flow at 50% of FVC (V50) were used as lung function indicators to examine effects of 10-μg/m3 increases in PM2.5 concentration on relative growth per 10-cm increase in height. RESULTS: Overall annual mean PM2.5 concentration was 13.5 μg/m3 (range: 10.4 to 19.0 µg/m3). We found no association between any of the lung function growth indicators and increases in PM2.5 levels in children of either sex, even after controlling for potential confounders. Analysis with two-pollutant models with O3 or NO2 did not change the null results. CONCLUSIONS: This nationwide longitudinal study suggests that concurrent, long-term exposure to PM2.5 at concentrations ranging from 10.4 to 19.0 μg/m3 has little effect on lung function growth in pre-adolescent boys and pre- to early adolescent girls. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (https://creativecommons.org/licenses/by-ncnd/4.0/). - 子宮内膜症既往と心血管疾患発症の関連 Japan Nurses' Health Studyでの検討
長井 万恵, 上田 佳代, 清原 裕, 磯 博康, 安井 敏之, 倉林 工, 井手野 由季, 林 邦彦
日本女性医学学会雑誌, 29, 1, 96, 96, (一社)日本女性医学学会, Oct. 2021
Japanese - 粒子状物質がSARS-CoV-2の細胞内侵入に関与するタンパク質の発現に与える影響
大森 一生, 石川 良賀, 本田 晶子, 佐川 友哉, 上田 佳代, 高野 裕久
大気環境学会年会講演要旨集, 62回, 312, 312, (公社)大気環境学会, Sep. 2021
Japanese - PM2.5の測定法と動態
山神 真紀子, 池盛 文数, 久恒 邦裕, 中島 寛則, 上田 佳代, 若松 伸司, 長田 和雄
大気環境学会年会講演要旨集, 62回, 88, 89, (公社)大気環境学会, Sep. 2021
Japanese - Assessment of Respiratory morbidity burden from exposure to vegetation fire-PM2.5 in Upper Northern Thailand for the year 2018
Athicha Uttajug, Kayo Ueda, Hirohisa Takano, Akiko Honda
ISEE Conference Abstracts, 2021, 1, Environmental Health Perspectives, 23 Aug. 2021
Scientific journal - Long-term air pollution exposure and serum lipids and blood sugar: A longitudinal cohort study from the electricity generating authority of Thailand study
Kanawat Paoin, Kayo Ueda, Prin Vathesatogkit, Thammasin Ingviya, Suhaimee Buya, Arthit Phosri, Xerxes Tesoro Seposo, Nisakron Thongmung, Teerapat Yingchoncharoen, Akiko Honda, Hirohisa Takano, Piyamitr Sritara
Atmospheric Environment, 259, 118515, 118515, Elsevier BV, Aug. 2021
Scientific journal - Effects of long-term air pollution exposure on ankle-brachial index and cardio-ankle vascular index: A longitudinal cohort study using data from the Electricity Generating Authority of Thailand study
Kanawat Paoin, Kayo Ueda, Prin Vathesatogkit, Thammasin Ingviya, Suhaimee Buya, Arthit Phosri, Xerxes Tesoro Seposo, Nisakron Thongmung, Teerapat Yingchoncharoen, Akiko Honda, Hirohisa Takano, Piyamitr Sritara
International Journal of Hygiene and Environmental Health, 236, 113790, 113790, Elsevier BV, Jul. 2021, [Peer-reviewed]
Scientific journal, 13712130 - Investigation of association between smoke haze and under-five mortality in Malaysia, accounting for time lag, duration and intensity
Vera Ling Hui Phung, Kayo Ueda, Mazrura Sahani, Xerxes Tesoro Seposo, Wan Rozita Wan Mahiyuddin, Akiko Honda, Hirohisa Takano
International Journal of Epidemiology, Oxford University Press (OUP), 20 Jun. 2021, [Peer-reviewed]
Scientific journal,Abstract
Background
Studies on the association between smoke haze (hereafter ‘haze’) and adverse health effects have increased in recent years due to extreme weather conditions and the increased occurrence of vegetation fires. The possible adverse health effects on under-five children (U5Y) is especially worrying due to their vulnerable condition. Despite continuous repetition of serious haze occurrence in Southeast Asia, epidemiological studies in this region remained scarce. Furthermore, no study had examined the association accounting for three important aspects (time lag, duration and intensity) concurrently.
Objective
This study aimed to examine the association between haze and U5Y mortality in Malaysia, considering time lag, duration and intensity of exposure.
Methods
We performed a time-stratified case-crossover study using a generalized additive model to examine the U5Y mortality related to haze in 12 districts in Malaysia, spanning from 2014 to 2016. A ‘haze day’ was characterized by intensity [based on concentrations of particulate matter (PM)] and duration (continuity of haze occurrence, up to 3 days).
Results
We observed the highest but non-significant odds ratios (ORs) of U5Y mortality at lag 4 of Intensity-3. Lag patterns revealed the possibility of higher acuteness at prolonged and intensified haze. Stratifying the districts by the 95th-percentile of PM distribution, the ‘low’ category demonstrated marginal positive association at Intensity-2 Duration-3 [OR: 1.210 (95% confidence interval: 1.000, 1.464)].
Conclusions
We found a null association between haze and U5Y mortality. The different lag patterns of the association observed over different duration and intensity suggest consideration of these aspects in future studies.
- Fine particulate matter and out-of-hospital cardiac arrest of respiratory origin.
Sunao Kojima, Takehiro Michikawa, Kunihiko Matsui, Hisao Ogawa, Shin Yamazaki, Hiroshi Nitta, Akinori Takami, Kayo Ueda, Yoshio Tahara, Naohiro Yonemoto, Hiroshi Nonogi, Ken Nagao, Takanori Ikeda, Yoshio Kobayashi
The European respiratory journal, 57, 6, Jun. 2021, [International Magazine]
English - Association between ambient temperature and intentional injuries: A case-crossover analysis using ambulance transport records in Japan
Ryusei Kubo, Kayo Ueda, Xerxes Seposo, Akiko Honda, Hirohisa Takano
Science of The Total Environment, 774, 145511, 145511, Elsevier BV, Jun. 2021, [Peer-reviewed], [Corresponding author]
Scientific journal - Trends in PM2.5 Concentration in Nagoya, Japan, from 2003 to 2018 and Impacts of PM2.5 Countermeasures
Makiko Yamagami, Fumikazu Ikemori, Hironori Nakashima, Kunihiro Hisatsune, Kayo Ueda, Shinji Wakamatsu, Kazuo Osada
ATMOSPHERE, 12, 5, May 2021, [Peer-reviewed]
English, Scientific journal, 13712126 - Association between PM10 from vegetation fire events and hospital visits by children in upper northern Thailand
Athicha Uttajug, Kayo Ueda, Kei Oyoshi, Akiko Honda, Hirohisa Takano
Science of The Total Environment, 764, 142923, 142923, Elsevier BV, Apr. 2021, [Peer-reviewed], [Corresponding author]
English, Scientific journal, Few studies have focused on the effects of exposure to air pollutants from vegetation fire events (including forest fire and the burning of crop residues) among children. In this study we aimed to investigate the association between PM₁₀ concentrations and hospital visits by children to address respiratory disease, conjunctivitis, and dermatitis. We examined and compared these associations by the presence of vegetation fire events on a given day (burning, non-burning, and mixed) across the upper northern region of Thailand from 2014 through 2018. A vegetation burning was defined when a fire hotspot (obtained from NASA-MODIS) exceeded the 90th percentile of the entire region and PM₁₀ concentration was over 100 μg/m³. To determine the association between hospital visits among children with PM₁₀ concentrations on burning and non-burning days, we performed a time-stratified case-crossover analysis fitted with conditional logistic regression for each province. A random-effects meta-analysis was applied to pool province-specific effect estimates. The number of burning days ranged from 64 to 139 days across eight provinces. A 10 μg/m³ increase in PM₁₀ concentration on a burning day was associated with a respiratory disease-related hospital visit at lag 0 (OR = 1.01 (95% CIs: 1.00, 1.02)). This association was not observed for hospital visits related to conjunctivitis and dermatitis. A positive association was also observed between PM₁₀ concentration on non-burning days and hospital visits related to respiratory disease at lag 0 (OR = 1.03 (95% CIs: 1.02, 1.04)). Hospital visits for conjunctivitis and dermatitis were significantly associated with PM₁₀ concentration at lag 0 on both non-burning and mixed days., 13712123 - 大気汚染への長期曝露と腎機能 タイ発電公社による縦断的コホート研究
パオイン・カナワット, 上田 佳代, ワァチサトキト・プリン, インウィヤ・タマシン, ブヤ・スハイメエ, セポソ・サークセス, キチヤカラ・チャグリヤ, トンムン・ニサコロン, 本田 晶子, 高野 裕久
日本衛生学雑誌, 76, Suppl., S144, S144, (一社)日本衛生学会, Mar. 2021
English - タイ、チェンライ県における野焼き禁止が呼吸器疾患による病院訪問に与える影響
アタッチャ・アティーシャ, 上田 佳代, 本田 晶子, 高野 裕久
日本衛生学雑誌, 76, Suppl., S144, S144, (一社)日本衛生学会, Mar. 2021
English - 日本の27都市におけるPM2.5と救急搬送の関係 都市の属性による影響修飾
梁 雨文, 上田 佳代, 須崎 純一, 楠瀬 智也, 高見 昭憲, 菅田 誠治, 吉野 彩子, 本田 晶子, 高野 裕久
日本衛生学雑誌, 76, Suppl., S144, S144, (一社)日本衛生学会, Mar. 2021
Japanese - 気温と意図的な傷害の関係 救急救助統計を使用したケースクロスオーバー解析
久保 龍征, 上田 佳代, 高野 裕久, 本田 晶子, セポソ・サーザス
日本衛生学雑誌, 76, Suppl., S166, S166, (一社)日本衛生学会, Mar. 2021
Japanese - Long-Term Exposure to Particulate Matter and Mortality from Cardiovascular Diseases in Japan: The Ibaraki Prefectural Health Study (IPHS)
Ayano Takeuchi, Yuji Nishiwaki, Tomonori Okamura, Ai Milojevic, Kayo Ueda, Keiko Asakura, Toru Takebayashi, Shuichi Hasegawa, Toshimi Sairenchi, Fujiko Irie, Hitoshi Ota, Hiroshi Nitta
Journal of Atherosclerosis and Thrombosis, 28, 3, 230, 240, Japan Atherosclerosis Society, 01 Mar. 2021, [Peer-reviewed]
Scientific journal - Effects of exposure to chemical components of fine particulate matter on mortality in Tokyo: A case-crossover study
Takehiro Michikawa, Shin Yamazaki, Kayo Ueda, Ayako Yoshino, Seiji Sugata, Shinji Saito, Junya Hoshi, Hiroshi Nitta, Akinori Takami
Science of The Total Environment, 755, 142489, 142489, Elsevier BV, Feb. 2021, [Peer-reviewed]
Scientific journal, 13712125 - 子宮内膜症既往と循環器疾患発生の関連 Japan Nurses' Health Studyでの検討
長井 万恵, 上田 佳代, 清原 裕, 磯 博康, 安井 敏之, 井手野 由季, 林 邦彦
Journal of Epidemiology, 31, Suppl., 119, 119, (一社)日本疫学会, Jan. 2021
Japanese - Long-term air pollution exposure and self-reported morbidity: A longitudinal analysis from the Thai cohort study (TCS)
Kanawat Paoin, Kayo Ueda, Thammasin Ingviya, Suhaimee Buya, Arthit Phosri, Xerxes Tesoro Seposo, Sam-ang Seubsman, Matthew Kelly, Adrian Sleigh, Akiko Honda, Hirohisa Takano, Jaruwan Chokhanapitak, Chaiyun Churewong, Suttanit Hounthasarn, Suwanee Khamman, Daoruang Pandee, Suttinan Pangsap, Tippawan Prapamontol, Janya Puengson, Wimalin Rimpeekool, Yodyiam Sangrattanakul, Sam-ang Seubsman, Boonchai Somboonsook, Nintita Sripaiboonkij, Pathumvadee Somsamai, Benjawan Tawatsupa, Arunrat Tangmunkongvorakul, Duangkae Vilainerun, Wanee Wimonwattanaphan, Chris Bain, Emily Banks, Cathy Banwell, Janneke Berecki-Gisolf, Bruce Caldwell, Gordon Carmichael, Tarie Dellora, Jane Dixon, Sharon Friel, David Harley, Susan Jordan, Matthew Kelly, Tord Kjellstrom, Lynette Lim, Roderick McClure, Anthony McMichael, Tanya Mark, Adrian Sleigh, Lyndall Strazdins, Tam Tran, Vasoontara Yiengprugsawan, Jiaying Zhao
Environmental Research, 192, 110330, 110330, Elsevier BV, Jan. 2021, [Peer-reviewed], [Corresponding author]
Scientific journal - Short-term effects of air pollution on daily single- and co-morbidity cardiorespiratory outpatient visits.
Xerxes Seposo, Kayo Ueda, Seiji Sugata, Ayako Yoshino, Akinori Takami
The Science of the total environment, 729, 138934, 138934, 10 Aug. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, Several studies have noted that the existence of comorbidities lead to an increase in the risk of premature mortality and morbidity. Most of the studies examining the effects of air pollution on comorbidity visits were from Northern American countries, with scarce literature from Asia. This study contributes to existing, yet limited understanding of air pollution-comorbidity by examining the effects of daily air pollutants on outpatient single morbidity and comorbid cardiorespiratory visits in Japan. A total of 1,452,505 outpatient cardiorespiratory visits were recorded among the 21 Japanese cities from 2013 to 2016. Daily outpatient cardiorespiratory visit data were obtained from a health insurance claims database managed by the Japan Medical Data Center Co., Ltd. (JMDC). A time-stratified case crossover analysis coupled with Generalized Additive Mixed Model was used to analyze the association of daily air pollutants (particulate matter 2.5 μm or less in diameter, ozone and nitrogen dioxide) on daily single (respiratory and cardiovascular) and comorbidity health outcomes. We further examined single and cumulative effects for 0-3 and 0-14 lag periods. Ozone, NO2, and PM2.5 were positively associated with cardiorespiratory visits in either shorter or longer lags, with more apparent comorbidity associations with NO2 exposure. A 10-unit increase in NO2, after adjusting for ozone, was associated with a 2.24% (95% CI: 1.34-3.15) and 6.49% (95% CI: 5.00-8.01) increase in comorbidity visit at Lag 0 (of Lag 0-3) and cumulative lag 0-3, respectively. Our results contribute to existing evidence suggesting that short-term and extended exposure to air pollution elicit health risks on cardiovascular, respiratory and comorbid clinic visits. Exposure to NO2, in particular, was associated with increase in the risk of single and comorbidity cardiorespiratory visits. Results can be potentially utilized for both individual health (e.g. risk population health management) and health facility management (e.g. health visit influx determination). - A development of reduction scenarios of the short-lived climate pollutants (SLCPs) for mitigating global warming and environmental problems
Teruyuki Nakajima, Toshimasa Ohara, Toshihiko Masui, Toshihiko Takemura, Kei Yoshimura, Daisuke Goto, Tatsuya Hanaoka, Syuichi Itahashi, Gakuji Kurata, Jun-ichi Kurokawa, Takashi Maki, Yuji Masutomi, Makiko Nakata, Tomoko Nitta, Xerxes Seposo, Kengo Sudo, Chieko Suzuki, Kentaroh Suzuki, Haruo Tsuruta, Kayo Ueda, Shingo Watanabe, Yong Yu, Keiya Yumimoto, Shuyun Zhao
PROGRESS IN EARTH AND PLANETARY SCIENCE, 7, 1, Jul. 2020
English, Scientific journal - パーソナルケア製品がアトピー性皮膚炎に及ぼす影響の評価
丹 嵯織, 本田 晶子, 宮坂 奈津子, 田中 満崇, 田村 紳, 岡野 人士, 王 造時, 長尾 慧, 上田 佳代, 高野 裕久
The Journal of Toxicological Sciences, 45, Suppl., S104, S104, (一社)日本毒性学会, Jun. 2020
Japanese - Hourly association between ambient PM2.5 and emergency ambulance dispatches in 11 cities in Japan.
Vera Ling Hui Phung, Kayo Ueda, Xerxes Seposo, Akinori Takami, Seiji Sugata, Ayako Yoshino, Takehiro Michikawa, Shin Yamazaki, Akiko Honda, Hirohisa Takano
Environmental research, 185, 109448, 109448, Jun. 2020, [Peer-reviewed], [International Magazine]
English, Numerous epidemiological studies have demonstrated that short-term exposure to ambient PM2.5 increases mortality and morbidity. Investigating the association using hourly ambient PM2.5 exposure may provide important insights, as current evidence is limited mostly to daily lag term. This study aimed to investigate the hourly association between ambient PM2.5 concentrations and all-cause emergency ambulance dispatches (EAD) in 11 cities in Japan. We used a time-stratified case-crossover design and examined the hourly lags of ambient PM2.5 up to 24 h (unconditional distributed lags and moving average lags) using a conditional Poisson regression model. A significant increase in all-cause EAD was observed at lag 0 h [relative risk (RR): 1.0037 (95% CI: 1.0000, 1.0074)] and all moving average lags. The highest RR was observed within the first 6 h (at lag 0-5 h) [RR: 1.0091 (95% CI: 1.0068, 1.0114)], with a slight ascending pattern. This was followed by a descending pattern at lags 0-11, 0-17, and 0-23 h, but significant positive RR was observed even at lag 0-23 h, when the lowest RR was observed [RR: 1.0072 (95% CI: 1.0044, 1.0100)]. Though similar pattern was observed among the elderly, a different pattern was observed among the children (gradually ascending pattern). We conclude that all-cause EAD could be triggered by ambient PM2.5 exposure with very short lags. - Association of Fine Particulate Matter Exposure With Bystander-Witnessed Out-of-Hospital Cardiac Arrest of Cardiac Origin in Japan.
Sunao Kojima, Takehiro Michikawa, Kunihiko Matsui, Hisao Ogawa, Shin Yamazaki, Hiroshi Nitta, Akinori Takami, Kayo Ueda, Yoshio Tahara, Naohiro Yonemoto, Hiroshi Nonogi, Ken Nagao, Takanori Ikeda, Naoki Sato, Hiroyuki Tsutsui
JAMA network open, 3, 4, e203043, 01 Apr. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, Importance: Out-of-hospital cardiac arrests (OHCAs) are a major public health concern and a leading cause of death worldwide. Exposure to ambient air pollution is associated with increases in morbidity and mortality and has been recognized as a leading contributor to global disease burden. Objective: To examine the association between short-term exposure to particulate matter with a diameter of 2.5 μm or smaller (PM2.5) and the incidence of OHCAs of cardiac origin and with the development of initial cardiac arrest rhythm. Design, Setting, and Participants: This case-control study used data from cases registered between January 1, 2005, and December 31, 2016, in the All-Japan Utstein Registry, a prospective, nationwide, population-based database for OHCAs across all 47 Japanese prefectures. These OHCA cases included patients who had bystander-witnessed OHCAs and for whom emergency medical services responders initiated resuscitation before hospital transfer. A case-crossover design was employed for the study analyses. A prefecture-specific, conditional logistic regression model to estimate odds ratios was applied, and a random-effects meta-analysis was used to obtain prefecture-specific pooled estimates. All analyses were performed from May 7, 2019, to January 23, 2020. Main Outcomes and Measures: The main outcome was the association of short-term PM2.5 exposure with the incidence of bystander-witnessed OHCAs of cardiac origin. The differences in the distribution of initial cardiac arrest rhythm in OHCAs among those with exposure to PM2.5 were also examined. Results: In total, 103 189 OHCAs witnessed by bystanders were included in the final analysis. Among the patients who experienced such OHCAs, the mean (SD) age was 75 (15.5) years, and 62 795 (60.9%) were men. Point estimates of the percentage increase for a 10-μg/m3 increase in PM2.5 at lag0-1 (difference in mean PM2.5 concentrations measured on the case day and 1 day before) demonstrated a statistically significantly higher incidence of OHCA across most of the 47 prefectures, without significant heterogeneity (I2 = 20.1%; P = .12). A stratified analysis found an association between PM2.5 exposure and OHCAs (% increase, 1.6; 95% CI, 0.1%-3.1%). An initial shockable rhythm, such as ventricular fibrillation or pulseless ventricular tachycardia (% increase, 0.6; 95% CI, -2.0% to 3.2%), was not associated with PM2.5 exposure. However, an initial nonshockable rhythm, such as pulseless electrical activity and asystole, was associated with PM2.5 exposure (% increase, 1.4; 95% CI, 0.1%-2.7%). Conclusions and Relevance: Findings from this study suggest that increased PM2.5 concentration is associated with bystander-witnessed OHCA of cardiac origin that commonly presents with nonshockable rhythm. The results support measures to reduce PM2.5 exposure to prevent OHCAs of cardiac origin. - Health effects of PM2.5 sources on children's allergic and respiratory symptoms in Fukuoka, Japan.
Taichi Sugiyama, Kayo Ueda, Xerxes Tesoro Seposo, Ayako Nakashima, Makoto Kinoshita, Hiroko Matsumoto, Fumikazu Ikemori, Akiko Honda, Hirohisa Takano, Takehiro Michikawa, Hiroshi Nitta
The Science of the total environment, 709, 136023, 136023, 20 Mar. 2020, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Exposure to fine particulate matter (PM2.5) is a potential aggravating factor for respiratory and allergic diseases. However, which PM2.5 sources are associated with such diseases remains unclear. This study aimed to investigate the association of PM2.5 sources with allergic and respiratory symptoms in schoolchildren. PM2.5 samples were collected in Fukuoka during the spring in 2014 and 2015. Asian dust was observed in 2014. Ion components, elemental components, and organic components were analyzed. Positive matrix factorization (PMF) was conducted to calculate PM2.5 concentrations from each source. Mixed logistic regression analysis with a random intercept for each schoolchild was performed to evaluate the association of components and sources with symptoms. Among 2317 schoolchildren, the mean prevalence was 28.9%, 23.6%, 11.2%, and 11.4% for lower respiratory, nasal, ocular, and skin symptoms, respectively. PMF identified the following six PM2.5 sources "Secondary sulfate and coal combustion", "Secondary nitrate", "Heavy oil combustion", "Sea salt", "Soil" and "Traffic emission". An interquartile range of PM2.5 mass was associated with nasal (Odds ratios 1.08, 95% confidence interval [1.03, 1.13]), ocular (1.10, [1.04, 1.16]), and skin symptoms (1.13, [1.06, 1.20]). Among the source factors, "Heavy oil combustion" was significantly associated with nasal symptom (1.11, [1.05, 1.18]) while "Sea salt" was associated with nasal (1.06, [1.02, 1.11]) and skin (1.073, [1.01, 1.14]) symptoms. We found "Soil", which might be affected by Asian dust, was associated with ocular (1.07, [1.03, 1.10]) and skin (1.05, [1.01, 1.08]) symptoms. Further studies in other seasons or places are needed to clarify the influence of PM2.5 sources on children's health. - Association between Asian dust exposure and respiratory function in children with bronchial asthma in Nagasaki Prefecture, Japan.
Takahiro Nakamura, Yuji Nishiwaki, Kunio Hashimoto, Ayano Takeuchi, Tasuku Kitajima, Kazuhiro Komori, Kasumi Tashiro, Hideki Hasunuma, Kayo Ueda, Atsushi Shimizu, Hiroshi Odajima, Hiroyuki Moriuchi, Masahiro Hashizume
Environmental health and preventive medicine, 25, 1, 8, 8, 04 Mar. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Studies on the adverse effects of Asian dust (AD) on respiratory function in children are scarce. The objective of this study was to examine the association between AD and respiratory function by measuring peak expiratory flow rates (PEFRs) in asthmatic children. METHODS: The study was carried out from March to May from 2014 through 2016. One hundred ten children with bronchial asthma were recruited from four hospitals in the Goto Islands and south Nagasaki area in Nagasaki prefecture. The parents were asked to record their children's PEFRs every morning/evening and clinical symptoms in an asthma diary. AD was assessed from light detection and ranging data, and a linear mixed-effects model was used to estimate the effects of AD on daily PEFR. Time-stratified case-crossover analyses were performed to examine the association between AD and asthma attacks defined by reduction levels in PEFR. RESULTS: AD was detected on 11 days in the Goto Islands, and on 23 days in the south Nagasaki area. After adjusting for age, sex, temperature, and daily oxidants, we found a consistent association between AD and a 1.1% to 1.7% decrease in PEFR in the mornings and a 0.7% to 1.3% decrease in the evenings at a lag of 0 to 5 days. AD was not associated with the number of asthma attacks, respiratory symptoms, or other symptoms at any lag days examined. CONCLUSIONS: Exposure to AD was associated with reduced PEFR, although the effects were not large enough to induce clinically apparent symptoms, in clinically well-controlled asthmatic children. - Association between PM
2.5 exposure and heart rate variability for the patients with cardiac problems in Japan
Kanawat Paoin, Kayo Ueda, Xerxes Tesoro Seposo, Junichiro Hayano, Ken Kiyono, Norihiro Ueda, Takashi Kawamura, Akiko Honda, Hirohisa Takano
Air Quality, Atmosphere and Health, 13, 3, 339, 347, 01 Mar. 2020, [Peer-reviewed], [Corresponding author]
Scientific journal - Fine Particulate Matter Triggers Out-of-Hospital Cardiac Arrest of Cardiac Origin: A Nationwide Registry-Based Study in Japan
Sunao Kojima, Takehiro Michikawa, Kunihiko Matsui, Hisao Ogawa, Shin Yamazaki, Hiroshi Nitta, Akinori Takami, Kayo Ueda, Yoshio Tahara, Naohiro Yonemoto, Hiroshi Nonogi, Ken Nagao, Takanori Ikeda, Naoki Sato, Hiroyuki Tsutsui
CIRCULATION, 140, 25, E970, E970, Dec. 2019, [Peer-reviewed]
English - 非線形回帰モデルを用いたオゾンの健康影響評価
長谷川 博史, 上田 佳代, Xerxes Seposo, 板野 泰之, 本田 晶子, 高野 裕久
大気環境学会年会講演要旨集, 60回, 2D0930, 2D0930, (公社)大気環境学会, Sep. 2019
Japanese - For making a declaration of countermeasures against the falling birth rate from the Japanese Society for Hygiene: summary of discussion in the working group on academic research strategy against an aging society with low birth rate
Kyoko Nomura, Kanae Karita, Atsuko Araki, Emiko Nishioka, Go Muto, Miyuki Iwai-Shimada, Mariko Nishikitani, Mariko Inoue, Shinobu Tsurugano, Naomi Kitano, Mayumi Tsuji, Sachiko Iijima, Kayo Ueda, Michihiro Kamijima, Zentaro Yamagata, Kiyomi Sakata, Masayuki Iki, Hiroyuki Yanagisawa, Masashi Kato, Hidekuni Inadera, Yoshihiro Kokubo, Kazuhito Yokoyama, Akio Koizumi, Takemi Otsuki
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 24, 1, UNSP 14, Springer Science and Business Media LLC, Mar. 2019, [Peer-reviewed]
English, Scientific journal - Effects of ambient air pollution on daily hospital admissions for respiratory and cardiovascular diseases in Bangkok, Thailand
Arthit Phosri, Kayo Ueda, Vera Ling Hui Phung, Benjawan Tawatsupa, Akiko Honda, Hirohisa Takano
SCIENCE OF THE TOTAL ENVIRONMENT, 651, 1144, 1153, ELSEVIER SCIENCE BV, Feb. 2019, [Peer-reviewed], [Corresponding author]
English, Scientific journal - Toward a Declaration to Address Japan's Aging Society with Low Birth Rate: Summary of the Japanese Society for Hygiene's Working Group on Academic Research Strategy against an Aging Society with Low Birth Rate
Kyoko Nomura, Kanae Karita, Atsuko Araki, Emiko Nishioka, Go Muto, Miyuki Iwai-Shimada, Mariko Nishikitani, Mariko Inoue, Shinobu Tsurugano, Naomi Kitano, Mayumi Tsuji, Sachiko Iijima, Kayo Ueda, Michihiro Kamijima, Zentaro Yamagata, Kiyomi Sakata, Masayuki Iki, Hiroyuki Yanagisawa, Masashi Kato, Kazuhito Yokoyama, Akio Koizumi, Takemi Otsuki
Nihon eiseigaku zasshi. Japanese journal of hygiene, 74, 2019
Scientific journal - Extract of curry powder and its components protect against diesel exhaust particle-induced inflammatory responses in human airway epithelial cells
Akiko Honda, Sho Ito, Michitaka Tanaka, Takahiro Sawahara, Tomohiro Hayashi, Wataru Fukushima, Gaku Kitamura, Hitomi Kudo, Pratiti Home Chowdhury, Hitoshi Okano, Toshinori Onishi, Yusuke Kawaryu, Makoto Higashihara, Hideki Nakayama, Kayo Ueda, Hirohisa Takano
Food and Agricultural Immunology, 30, 1, 1212, 1224, Informa UK Limited, 01 Jan. 2019, [Peer-reviewed]
Scientific journal - [Effect of City-Specific Characteristics on Association between Heat and Ambulance Dispatches].
Kazuya Kotani, Kayo Ueda, Xerxes Seposo, Masaji Ono, Akiko Honda, Hirohisa Takano
Nihon eiseigaku zasshi. Japanese journal of hygiene, 74, 0, 2019, [Peer-reviewed], [Corresponding author], [Domestic magazines]
Japanese, Scientific journal, OBJECTIVES: In this multicity study, we aimed to elucidate the city-specific factors affecting the association of high ambient temperature with ambulance dispatches due to acute illnesses. METHODS: We used the data of ambulance dispatches in 27 cities in Japan with more than 500,000 population excluding Tokyo, from May to September from 2012 to 2015. We included patients 20 years and older (≥20 years) and stratified them into three age groups (20-59, 60-79, and ≥80 years). We explored the city-specific pattern of the daily relative temperature (in temperature percentiles) and the risk of ambulance dispatches for each age group using a distributed lag nonlinear model and estimated the city-specific relative risks of ambulance dispatches at the 95/99 percentile temperature compared with the 77.6 percentile temperature defined as the reference temperature (Tref). Then, the estimates were combined by performing meta-analyses for each age group. We also applied meta-regression models to explore whether the city-specific characteristics modified the association of temperature with ambulance dispatches. RESULTS: The relative risks of the 95th percentile with respect to Tref were 1.14 (95% confidence interval (CI): 1.12, 1.16), 1.16 (95% CI: 1.13, 1.20), 1.13 (95% CI: 1.10, 1.16), and 1.13 (95% CI: 1.00, 1.16), for all-age (≥20) and age-stratified groups (20-59, 60-79, and ≥80 years), respectively. We observed a higher relative risk for the ≥20 years age group in the cities with higher proportions of single-elderly, single-mother, and single-father households. We also found that the relative risk for the 20-59 years age group was higher in the cities with a higher proportion of blue-collar workers. CONCLUSIONS: The present study provides insights into city-specific characteristics modifying heat-related health effects. - Effect of global atmospheric aerosol emission change on PM2.5-related health impacts.
Xerxes Seposo, Kayo Ueda, Sang Seo Park, Kengo Sudo, Toshihiko Takemura, Teruyuki Nakajima
Global health action, 12, 1, 1664130, 1664130, 2019, [International Magazine]
English, Scientific journal, Background: Previous research has highlighted the importance of major atmospheric aerosols such as sulfate, through its precursor sulfur dioxide (SO2), black carbon (BC), and organic carbon (OC), and their effect on global climate regimes, specifically on their impact on particulate matter measuring ≤ 2.5 μm (PM2.5). Policy regulations have attempted to address the change in these major active aerosols and their impact on PM2.5, which would presumably have a cascading effect toward the change of health risks. Objective: This study aimed to determine how the change in the global emissions of anthropogenic aerosols affects health, particularly through the change in attributable mortality (AN) and years of life lost (YLL). This study also aimed to explore the importance of using AM/YLL in conveying air pollution health impact message. Methods: The Model for Interdisciplinary Research on Climate was used to estimate the gridded atmospheric PM2.5 by changing the emission of SO2, BC, and OC. Next, the emissions were utilized to estimate the associated cause-specific risks via an integrated exposure-response function, and its consequent health indicators, AM and YLL, per country. Results: OC change yielded the greatest benefit for all country income groups, particularly among low-middle-income countries. Utilizing either AM or YLL did not alter the order of benefits among upper-middle and high-income countries (UMIC/HIC); however, using either health indicator to express the order of benefit varied among low- and low-middle-income countries (LIC/LMIC). Conclusions: Global and country-specific mitigation efforts focusing on OC-related activities would yield substantial health benefits. Substantial aerosol emission reduction would greatly benefit high-emitting countries (i.e. China and India). Although no difference is found in the order of health outcome benefits in UMIC/HIC, caution is warranted in using either AM or YLL for health impact assessment in LIC/LMIC. - Health impact assessment of PM2.5-related mitigation scenarios using local risk coefficient estimates in 9 Japanese cities.
Xerxes Seposo, Masahide Kondo, Kayo Ueda, Yasushi Honda, Takehiro Michikawa, Shin Yamazaki, Hiroshi Nitta
Environment international, 120, 525, 534, PERGAMON-ELSEVIER SCIENCE LTD, Nov. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, Previous studies have highlighted the negative effects of PM2.5 on mortality, expressed in terms of attributable deaths and life years lost. However, there are very few studies assessing the health impacts of air pollution in terms of economic burden/benefits. This study assessed the health impact of two hypothetical interventions among sex- and age-specific risk populations using a robust risk estimation and economic valuation process. We utilized the sex- and age-stratified daily all-cause mortality together with the daily PM2.5 of the 9 Japanese cities from 2002 to 2008 in estimating the relative risks. The estimated risks were then utilized for the economic valuation of co-benefits/burden with respect to the two hypothetical PM2.5-related mitigation scenarios, in comparison to status quo, namely: i) decrease to Japanese standards, and ii) decrease to WHO standards. Impact of these interventions on health were assessed using the following HIA metrics: attributable mortality, attributable years life lost, and environmental health impact. A 10-μg/m3 increase in PM2.5 would increase the risk by 0.52% (95% CI: -0.91% to 1.99%) for all-cause mortality, with varying risk estimates per subgroup. High economic burdens were estimated at status quo, with particularly distinct burden difference for age-specific mortality; 0.40 trillion yen (0-64 y.o.) and 1.50 trillion yen (>64 y.o.). If stricter standards, relative to status quo, were to be enforced, i.e. WHO standard, there is a potential to yield economic benefits in the same risk population; 0.26 trillion yen (0-64 y.o.) and 0.98 trillion yen (>64 y.o.). We did not observe any substantial difference with the burden and benefit related to sex-specific mortality. Using the estimated local risk coefficients complemented with the valuation of the risks, policymaking entities will have the opportunity to operate their own HIA to assess the relevant air pollution-related health impacts. - 教室情報 環境工学現場見学会2018報告
上田 佳代, 小坂 浩司
環境衛生工学研究 = Environmental & sanitary engineering research : 京都大学環境衛生工学研究会機関誌, 32, 4, 50, 52, 京都大学環境衛生工学研究会, Nov. 2018
Japanese, Scientific journal - Japanese Nationwide Study on the Association between Short-term Exposure to Particulate Matter and Mortality.
T. Michikawa, K. Ueda, A. Takami, S. Sugata, A. Yoshino, H. Nitta, S. Yamazaki
J Epidemiol., 29, 12, JE20180122, 477, Oct. 2018, [Peer-reviewed]
English, Scientific journal - 名古屋市におけるPM2.5の化学成分の長期変動(2003〜2017年度)
山神 真紀子, 久恒 邦裕, 池盛 文数, 森 健次, 長田 和雄, 上田 佳代
大気環境学会年会講演要旨集, 59回, 480, 480, (公社)大気環境学会, Aug. 2018
Japanese - Health impact assessment of PM-related mitigation scenarios using local risk coefficient estimates in 9 Japanese cities
Seposo, Xerxes, Kondo, Masahide, Ueda, Kayo, Honda, Yasushi, Michikawa, Takehiro, Yamazaki, Shin, Nitta, Hiroshi
Environment international, 120, 525, 534, PERGAMON-ELSEVIER SCIENCE LTD, Aug. 2018, [Peer-reviewed]
English, Scientific journal, Previous studies have highlighted the negative effects of PM on mortality, expressed in terms of attributable deaths and life years lost. However, there are very few studies assessing the health impacts of air pollution in terms of economic burden/benefits. This study assessed the health impact of two hypothetical interventions among sex- and age-specific risk populations using a robust risk estimation and economic valuation process. We utilized the sex- and age-stratified daily all-cause mortality together with the daily PM of the 9 Japanese cities from 2002 to 2008 in estimating the relative risks. The estimated risks were then utilized for the economic valuation of co-benefits/burden with respect to the two hypothetical PM-related mitigation scenarios, in comparison to status quo, namely: i) decrease to Japanese standards, and ii) decrease to WHO standards. Impact of these interventions on health were assessed using the following HIA metrics: attributable mortality, attributable years life lost, and environmental health impact. A 10-μg/m increase in PM would increase the risk by 0.52% (95% CI: -0.91% to 1.99%) for all-cause mortality, with varying risk estimates per subgroup. H - Epidemiological approaches to characterize human health risks from environmental exposure in a watershed
Kayo Ueda, Hirohisa Takano
Environmental Risk Analysis for Asian-Oriented, Risk-Based Watershed Management: Japan and Malaysia, 95, 102, Springer Singapore, 07 May 2018
English, In book - Aqueous and organic extract of PM2.5 collected in different seasons and cities of Japan differently affect respiratory and immune systems
Pratiti Home Chowdhury, Hitoshi Okano, Akiko Honda, Hitomi Kudou, Gaku Kitamura, Sho Ito, Kayo Ueda, Hirohisa Takano
Environmental Pollution, 235, 223, 234, Elsevier Ltd, 01 Apr. 2018
English, Scientific journal - 日本の主要都市における粗大粒子短期曝露と死亡の関連性についての検討
道川武紘, 上田佳代, 高見昭憲, 菅田誠治, 吉野彩子, 新田裕史, 山崎新
日本衛生学雑誌(Web), 73, Supplement, S231, Mar. 2018
Japanese - Acute Effects of Ambient PM2.5 on All-Cause and Cause-Specific Emergency Ambulance Dispatches in Japan.
Vera Ling Hui Phung, Kayo Ueda, Shunji Kasaoka, Xerxes Seposo, Saira Tasmin, Shinichi Yonemochi, Arthit Phosri, Akiko Honda, Hirohisa Takano, Takehiro Michikawa, Hiroshi Nitta
International journal of environmental research and public health, 15, 2, 307, MDPI, 09 Feb. 2018, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, Short-term health effects of ambient PM2.5 have been established with numerous studies, but evidence in Asian countries is limited. This study aimed to investigate the short-term effects of PM2.5 on acute health outcomes, particularly all-cause, cardiovascular, respiratory, cerebrovascular and neuropsychological outcomes. We utilized daily emergency ambulance dispatches (EAD) data from eight Japanese cities (2007-2011). Statistical analyses included two stages: (1) City-level generalized linear model with Poisson distribution; (2) Random-effects meta-analysis in pooling city-specific effect estimates. Lag patterns were explored using (1) unconstrained-distributed lags (lag 0 to lag 7) and (2) average lags (lag: 0-1, 0-3, 0-5, 0-7). In all-cause EAD, significant increases were observed in both shorter lag (lag 0: 1.24% (95% CI: 0.92, 1.56)) and average lag 0-1 (0.64% (95% CI: 0.23, 1.06)). Increases of 1.88% and 1.48% in respiratory and neuropsychological EAD outcomes, respectively, were observed at lag 0 per 10 µg/m³ increase in PM2.5. While respiratory outcomes demonstrated significant average effects, no significant effect was observed for cardiovascular outcomes. Meanwhile, an inverse association was observed in cerebrovascular outcomes. In this study, we observed that effects of PM2.5 on all-cause, respiratory and neuropsychological EAD were acute, with average effects not exceeding 3 days prior to EAD onset. - Effect of streamer plasma irradiation on ambient PM2.5-induced proinflammatory responses in human bronchial epithelial cells
Toshio Tanaka, Shin Tamura, Akiko Honda, Michitaka Tanaka, Hitoshi Okano, Toshinori Onishi, Satsuki Takai, Wang Zaoshi, Kayo Ueda, Hirohisa Takano
15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018, International Society of Indoor Air Quality and Climate, 2018
English, International conference proceedings - Ambient fine and coarse particles collected at three locations in Japan using cyclone technique affect upper and lower respiratory tract differently and elicit varying immune response
Onishi, Toshinori, Honda, Akiko, Tanaka, Michitaka, Chowdhury, Pratiti Home, Okano, Hitoshi, Okuda, Tomoaki, Shishido, Daiki, Terui, Yoshihiro, Hasagawa, Shuichi, Kameda, Takayuki, Tohno, Susumu, Hayashi, Masahiko, Nishita-Hara, Chiharu, Hara, Keiichiro, Inoue, Kozo, Ueda, Kayo, Takano, Hirohisa
Environmental Pollution, 242, Pt B, 1693, 1701, 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, Ambient particulate matter (PM) epidemiologically exacerbates respiratory and immune health, including allergic rhinitis (AR) and bronchial asthma (BA). Although fine and coarse particles can affect respiratory tract, the differences in their effects on the upper and lower respiratory tract and immune system, their underlying mechanism, and the components responsible for the adverse health effects have not been yet completely elucidated. In this study, ambient fine and coarse particles were collected at three different locations in Japan by cyclone technique. Both particles collected at all locations decreased the viability of nasal epithelial cells and antigen presenting cells (APCs), increased the production of IL-6, IL-8, and IL-1β from bronchial epithelial cells and APCs, and induced expression of dendritic and epithelial cell (DEC) 205 on APCs. Differences in inflammatory responses, but not in cytotoxicity, were shown between both particles, and among three locations. Some components such as Ti, Co, Zn, Pb, As, OC (organic carbon) and EC (elemental carbon) showed significant correlations to inflammatory responses or cytotoxicity. These results suggest that ambient fine and coarse particles differently affect nasal and bronchial epithelial cells and immune response, which may depend on particles size diameter, chemical composition and source related particles types. - Effects of high ambient temperature on ambulance dispatches in different age groups in Fukuoka, Japan.
Kazuya Kotani, Kayo Ueda, Xerxes Seposo, Shusuke Yasukochi, Hiroko Matsumoto, Masaji Ono, Akiko Honda, Hirohisa Takano
Global health action, 11, 1, 1437882, 1437882, 2018, [Peer-reviewed], [Corresponding author], [International Magazine]
English, BACKGROUND: The elderly population has been the primary target of intervention to prevent heat-related illnesses. According to the literature, the highest risks have been observed among the elderly in the temperature-mortality relationship. However, findings regarding the temperature-morbidity relationship are inconsistent. OBJECTIVES: This study aimed to examine the association of temperature with ambulance dispatches due to acute illnesses, stratified by age group. Specifically, we explored the optimum temperature, at which the relative health risks were found to be the lowest, and quantified the health risk associated with higher temperatures among different age groups. METHODS: We used the data for ambulance dispatches in Fukuoka, Japan, during May and September from 2005 to 2012. The data were grouped according to age in 20-year increments. We explored the pattern of the association of ambulance dispatches with temperature using a smoothing spline curve to identify the optimum temperature for each age group. Then, we applied a distributed lag nonlinear model to estimate the risks of the 85th-95th percentile temperature relative to the overall optimum temperature, for each age group. RESULTS: The relative risk of ambulance dispatches at the 85th and 95th percentile temperature for all ages was 1.08 [95% confidence interval (CI): 1.05, 1.12] and 1.12 (95% CI: 1.08, 1.16), respectively. In comparison, among age groups, the optimum temperature was observed as 25.0°C, 23.2°C, and 25.3°C for those aged 0-19, 60-79, and ≥80, respectively. The optimum temperature could not be determined for those aged 20-39 and 40-59. The relative risks of high temperature tended to be higher for those aged 20-39 and 40-59 than those for other age groups. CONCLUSIONS: We did not find any definite difference in the effect of high temperature on ambulance dispatches for different age groups. However, more measures should be taken for younger and middle-aged people to avoid heat-related illnesses. - Sensitivities of Simulated Source Contributions and Health Impacts of PM2.5 to Aerosol Models
Yu Morino, Kayo Ueda, Akinori Takami, Tatsuya Nagashima, Kiyoshi Tanabe, Kei Sato, Tadayoshi Noguchi, Toshinori Ariga, Keisuke Matsuhashi, Toshimasa Ohara
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 51, 24, 14273, 14282, Dec. 2017
English, Scientific journal - Aerosol Health Effects from Molecular to Global Scales
Manabu Shiraiwa, Kayo Ueda, Andrea Pozzer, Gerhard Lammel, Christopher J. Kampf, Akihiro Fushimi, Shinichi Enami, Andrea M. Arangio, Janine Froehlich-Nowoisky, Yuji Fujitani, Akiko Furuyama, Pascale S. J. Lakey, Jos Lelieveld, Kurt Lucas, Yu Morino, Ulrich Poeschl, Satoshi Takaharna, Akinori Takami, Haijie Tong, Bettina Weber, Ayako Yoshino, Kei Sato
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 51, 23, 13545, 13567, Dec. 2017
English, Scientific journal - Asian dust exposure triggers acute myocardial infarction
Sunao Kojima, Takehiro Michikawa, Kayo Ueda, Tetsuo Sakamoto, Kunihiko Matsui, Tomoko Kojima, Kenichi Tsujita, Hisao Ogawa, Hiroshi Nitta, Akinori Takami
EUROPEAN HEART JOURNAL, 38, 43, 3202, 3208, Nov. 2017
English, Scientific journal - Synergistic effect of carbon nuclei and polyaromatic hydrocarbons on respiratory and immune responses
Pratiti H. Chowdhury, Gaku Kitamura, Akiko Honda, Takahiro Sawahara, Tomohiro Hayashi, Wataru Fukushima, Hitomi Kudo, Sho Ito, Seiichi Yoshida, Takamichi Ichinose, Kayo Ueda, Hirohisa Takano
ENVIRONMENTAL TOXICOLOGY, 32, 9, 2172, 2181, Sep. 2017
English, Scientific journal - Blood pressure-lowering effect of Shinrin-yoku (Forest bathing): a systematic review and meta-analysis
Yuki Ideno, Kunihiko Hayashi, Yukina Abe, Kayo Ueda, Hiroyasu Iso, Mitsuhiko Noda, Jung-Su Lee, Shosuke Suzuki
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 17, 1, 409, Aug. 2017
English, Scientific journal - Interactive effects of specific fine particulate matter compositions and airborne pollen on frequency of clinic visits for pollinosis in Fukuoka, Japan
Arthit Phosri, Kayo Ueda, Saira Tasmin, Reiko Kishikawa, Masahiko Hayashi, Keiichiro Hara, Yamato Uehara, Vera Ling Hui Phung, Shusuke Yasukouchi, Shoko Konishi, Akiko Honda, Hirohisa Takano
ENVIRONMENTAL RESEARCH, 156, 411, 419, Jul. 2017, [Corresponding author]
English, Scientific journal - Synergic effects of 9,10-phenanthrenequinone and cadmium on pro-inflammatory responses in airway epithelial cells
Akiko Honda, Pratiti Home Chowdhury, Sho Ito, Hitoshi Okano, Toshinori Onishi, Yusuke Kawaryu, Kayo Ueda, Hirohisa Takano
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 52, 276, 279, Jun. 2017, [Peer-reviewed]
English, Scientific journal - Biological factor related to Asian sand dust particles contributes to the exacerbation of asthma
Akiko Honda, Takahiro Sawahara, Tomohiro Hayashi, Kenshi Tsuji, Wataru Fukushima, Mizuki Oishi, Gaku Kitamura, Hitomi Kudo, Sho Ito, Seiichi Yoshida, Takamichi Ichinose, Kayo Ueda, Hirohisa Takano
JOURNAL OF APPLIED TOXICOLOGY, 37, 5, 583, 590, May 2017, [Peer-reviewed]
English, Scientific journal - Effects of Components of PM2.5 Collected in Japan on the Respiratory and Immune Systems
Akiko Honda, Wataru Fukushima, Mizuki Oishi, Kenshi Tsuji, Takahiro Sawahara, Tomohiro Hayashi, Hitomi Kudo, Yuji Kashima, Katsuyuki Takahashi, Hideki Sasaki, Kayo Ueda, Hirohisa Takano
INTERNATIONAL JOURNAL OF TOXICOLOGY, 36, 2, 153, 164, Mar. 2017, [Peer-reviewed]
English, Scientific journal - Short-Term Exposure to Fine Particulate Matter and Risk of Ischemic Stroke
Ryu Matsuo, Takehiro Michikawa, Kayo Ueda, Tetsuro Ago, Hiroshi Nitta, Takanari Kitazono, Masahiro Kamouchi
STROKE, 47, 12, 3032, 3034, Dec. 2016, [Peer-reviewed]
English, Scientific journal - Asian Dust and Pediatric Emergency Department Visits Due to Bronchial Asthma and Respiratory Diseases in Nagasaki, Japan
Takahiro Nakamura, Masahiro Hashizume, Kayo Ueda, Atsushi Shimizu, Ayano Takeuchi, Tatsuhiko Kubo, Kunio Hashimoto, Hiroyuki Moriuchi, Hiroshi Odajima, Tasuku Kitajima, Kasumi Tashiro, Kunio Tomimasu, Yuji Nishiwaki
JOURNAL OF EPIDEMIOLOGY, 26, 11, 593, 601, Nov. 2016, [Peer-reviewed]
English, Scientific journal - Short-term exposure to ambient particulate matter and emergency ambulance dispatch for acute illness in Japan
Saira Tasmin, Kayo Ueda, Andrew Stickley, Shinya Yasumoto, Vera Ling Hui Phung, Mizuki Oishi, Shusuke Yasukouchi, Yamato Uehara, Takehiro Michikawa, Hiroshi Nitta
SCIENCE OF THE TOTAL ENVIRONMENT, 566, 528, 535, Oct. 2016, [Peer-reviewed]
English, Scientific journal - Estimation of excess mortality due to long-term exposure to PM2.5 in Japan using a high-resolution model for present and future scenarios
Daisuke Goto, Kayo Ueda, Chris Fook Sheng Ng, Akinori Takami, Toshinori Ariga, Keisuke Matsuhashi, Teruyuki Nakajima
ATMOSPHERIC ENVIRONMENT, 140, 320, 332, Sep. 2016, [Peer-reviewed]
English, Scientific journal - Heat-related mortality: Effect modification and adaptation in Japan from 1972 to 2010
Chris Fook Sheng Ng, Melanie Boeckmann, Kayo Ueda, Hajo Zeeb, Hiroshi Nitta, Chiho Watanabe, Yasushi Honda
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 39, 234, 243, Jul. 2016, [Peer-reviewed]
English, Scientific journal - Cross-sectional association between exposure to particulate matter and inflammatory markers in the Japanese general population: NIPPON DATA2010
Takehiro Michikawa, Tomonori Okamura, Hiroshi Nitta, Yuji Nishiwaki, Toru Takebayashi, Kayo Ueda, Aya Kadota, Akira Fujiyoshi, Takayoshi Ohkubo, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura
ENVIRONMENTAL POLLUTION, 213, 460, 467, Jun. 2016, [Peer-reviewed]
English, Scientific journal - Associations Between Fine Particulate Matter Components and Daily Mortality in Nagoya, Japan
Kayo Ueda, Makiko Yamagami, Fumikazu Ikemori, Kunihiro Hisatsune, Hiroshi Nitta
JOURNAL OF EPIDEMIOLOGY, 26, 5, 249, 257, May 2016, [Peer-reviewed]
English, Scientific journal - Synergistic effect of Carbon nuclei and Polyaromatic hydrocarbons on respiratory and immune responses.
P H Chowdhury, G Kitamura, A Honda, T Sawahara, T Hayashi, W Fukushima, H Kudou, S Ito, S Yoshida, T Ichinose, K Ueda, H Takano
Environmental Toxicology, 32, 9, 2172, 2181, Jan. 2016, [Peer-reviewed]
English, Scientific journal - PM₂.₅による健康影響 : 循環器疾患 (特集 微小粒子状物質PM₂.₅ : 基礎を知り,対策を考える)
上田 佳代
保健の科学, 58, 9, 596, 600, 杏林書院, Jan. 2016
Japanese, Scientific journal - Effects of Long-term Exposure to Fine Particulate Matter on Mortality: Systematic Review and Meta-analysis on Assessment of Exposure and Health Effects in Epidemiological Studies
Ueda Kayo, Tasmin Saira, Takami Akinori, Goto Daisuke, Oishi Mizuki, Ling Hui Phung Vera, Yasukochi Shusuke, Home Chowdhury Pratiti
Journal of Japan Society for Atmospheric Environment / Taiki Kankyo Gakkaishi, 51, 6, 245, 256, Japan Society for Atmospheric Environment, Jan. 2016, [Peer-reviewed]
Japanese, Scientific journal,A systematic review was conducted to evaluate the effects of long-term exposure to particulate matter with diameters of less than 2.5 μm (PM2.5) on mortality. We searched PubMed for epidemiological studies investigating the association of long-term exposure to PM2.5 with mortality published between January 1990 and December 2015. We applied a random-effects model to calculate the combined effect estimates for PM2.5 mass. Twenty-four articles were identified (3 from Asia, 6 from Europe, and 15 from North America). It was common to assign the PM2.5 observations monitored at a fixed-site station to all residents in the corresponding area in the study published during 1990–2000. Recently, PM2.5 exposure assessment has utilized dispersion models, land use regression models, and satellite remote sensing. The mean or median concentration of PM2.5 for each study area varied from 8.1 to 35.3 μg/m3. The combined risk ratio was 1.07 (95% confidence interval: 1.04, 1.19) per 10 μg/m3 increase in the PM2.5 concentration. There was a significant heterogeneity. Further studies are needed in the area where the PM2.5 level is high.
- Cross-sectional association between exposure to particulate matter and inflammatory markers in the Japanese general population.
T Michikawa, T Okamura, H Nitta, Y Nishiwaki, T Takebayashi, K Ueda, A Kadota, A Fujiyoshi, T Ohkubo, H Ueshima, A Okayama, K Miura
Environmental Pollution, 213, 460, 467, Jan. 2016, [Peer-reviewed]
English, Scientific journal - PM₂.₅による健康影響 : 循環器疾患 (特集 微小粒子状物質PM₂.₅ : 基礎を知り,対策を考える)
上田 佳代
保健の科学, 58, 9, 596, 600, 杏林書院, Jan. 2016
Japanese - A register-based study of the association between air pollutants and hypertensive disorders in pregnancy among the Japanese population
Takehiro Michikawa, Seiichi Morokuma, Kotaro Fukushima, Kayo Ueda, Ayano Takeuchi, Kiyoko Kato, Hiroshi Nitta
ENVIRONMENTAL RESEARCH, 142, 644, 650, Oct. 2015, [Peer-reviewed]
English, Scientific journal - A register-based study of the association between air pollutants and hypertensive disorders in pregnancy among the Japanese population
Takehiro Michikawa, Seiichi Morokuma, Kotaro Fukushima, Kayo Ueda, Ayano Takeuchi, Kiyoko Kato, Hiroshi Nitta
Environmental Research, 142, 644, 650, Academic Press Inc., 01 Oct. 2015
English, Scientific journal - Development of Seamless Chemical Assimilation System and Its Application for Atmospheric Environmental Materials
Nakajima Teruyuki, Imasu Ryoichi, Takami Akinori, Goto Daisuke, Tsuruta Haruo, Uchida Junya, Dai Tie, Misawa Shota, Ueda Kayo, Ng Chris Fook Sheng, Watanabe Chiho, Konishi Shoko, Sato Yousuke, Higuchi Atsushi, Masutomi Yuji, Murakami Akinobu, Tsuchiya Kazuaki, Kondo Hiroaki, Niwa Yousuke, Yoshimura Kei, Ohara Toshimasa, Morino Yu, Schutgens Nick, Sudo Kengo, Takemura Toshihiko, Inoue Toshiro, Arai Yutaka, Murata Ryo, Yonemoto Ryoma, Trieu Tran Thi Ngoc, Uematsu Mitsuo, Satoh Masaki, Tomita Hirofumi, Yashiro Hisashi, Hara Masayuki
Journal of the Japan Society for Simulation Technology, 34, 2, 104, 114, Japan Society for Simmulation Technology, Jun. 2015
Japanese, Scientific journal - The Relationship Between Asian Dust Events and Out-of-Hospital Cardiac Arrests in Japan
Takahiro Nakamura, Masahiro Hashizume, Kayo Ueda, Tatsuhiko Kubo, Atsushi Shimizu, Tomonori Okamura, Yuji Nishiwaki
JOURNAL OF EPIDEMIOLOGY, 25, 4, 289, 296, Apr. 2015, [Peer-reviewed]
English, Scientific journal - Community trial on heat related-illness prevention behaviors and knowledge for the elderly
Noriko Takahashi, Rieko Nakao, Kayo Ueda, Masaji Ono, Masahide Kondo, Yasushi Honda, Masahiro Hashizume
International Journal of Environmental Research and Public Health, 12, 3, 3188, 3214, MDPI AG, 17 Mar. 2015, [Peer-reviewed]
English, Scientific journal - Coarse particulate matter and emergency ambulance dispatches in Fukuoka, Japan: a time-stratified case-crossover study
Takehiro Michikawa, Kayo Ueda, Ayano Takeuchi, Kenji Tamura, Makoto Kinoshita, Takamichi Ichinose, Hiroshi Nitta
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 20, 2, 130, 136, Mar. 2015, [Peer-reviewed]
English, Scientific journal - 大気汚染と脳梗塞・心血管疾患の発生・増悪 (特集 大気汚染による呼吸器・循環器疾患は増加している)
上田 佳代
日本医事新報, 4766, 30, 35, 日本医事新報社, Jan. 2015
Japanese, Scientific journal - Application of a global nonhydrostatic model with a stretched-grid system to regional aerosol simulations around Japan
D. Goto, T. Dai, M. Satoh, H. Tomita, J. Uchida, S. Misawa, T. Inoue, H. Tsuruta, K. Ueda, C. F. S. Ng, A. Takami, N. Sugimoto, A. Shimizu, T. Ohara, T. Nakajima
GEOSCIENTIFIC MODEL DEVELOPMENT, 8, 2, 235, 259, 2015, [Peer-reviewed]
English, Scientific journal - Impact of short-term exposure to fine particulate matter on emergency ambulance dispatches in Japan
Takehiro Michikawa, Kayo Ueda, Ayano Takeuchi, Makoto Kinoshita, Hiromi Hayashi, Takamichi Ichinose, Hiroshi Nitta
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 69, 1, 86, 91, Jan. 2015, [Peer-reviewed]
English, Scientific journal - 大気汚染と脳梗塞・心血管疾患の発生・増悪 (特集 大気汚染による呼吸器・循環器疾患は増加している)
上田 佳代
日本医事新報, 4766, 30, 35, 日本医事新報社, Jan. 2015
Japanese - Particulate matter modifies the association between airborne pollen and daily medical consultations for pollinosis in Tokyo
Shoko Konishi, Chris Fook Sheng Ng, Andrew Stickley, Shinichi Nishihata, Chisa Shinsugi, Kayo Ueda, Akinori Takami, Chiho Watanabe
SCIENCE OF THE TOTAL ENVIRONMENT, 499, 125, 132, Nov. 2014, [Peer-reviewed]
English, Scientific journal - Desert Dust Is a Risk Factor for the Incidence of Acute Myocardial Infarction in Western Japan
Ryuichi Matsukawa, Takehiro Michikawa, Kayo Ueda, Hiroshi Nitta, Tomohiro Kawasaki, Hideki Tashiro, Masahiro Mohri, Yusuke Yamamoto
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES, 7, 5, 743, U158, Sep. 2014, [Peer-reviewed]
English, Scientific journal - Desert dust is a risk factor for the incidence of acute myocardial infarction in Western Japan.
Matsukawa R, Michikawa T, Ueda K, Nitta H, Kawasaki T, Tashiro H, Mohri M, Yamamoto Y
Circulation. Cardiovascular quality and outcomes, 7, 5, 743, 748, Sep. 2014, [Peer-reviewed] - Characterizing the effect of summer temperature on heatstroke-related emergency ambulance dispatches in the Kanto area of Japan
Chris Fook Sheng Ng, Kayo Ueda, Masaji Ono, Hiroshi Nitta, Akinori Takami
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY, 58, 5, 941, 948, Jul. 2014, [Peer-reviewed]
English, Scientific journal - 日本の大気環境と健康への影響 (特集 最近の大気汚染とアレルギー疾患) -- (大気環境の変化)
新田 裕史, 上田 佳代
アレルギー・免疫, 21, 10, 1475, 1483, 医薬ジャーナル社, Jan. 2014
Japanese, Scientific journal - Environmental pollutants and Allergy
本田 晶子, 上田 佳代, 高野 裕久
日本予防医学会雑誌, 9, 2, 61, 66, 日本予防医学会, Jan. 2014, [Peer-reviewed]
Japanese, Scientific journal - C461 都市における大気汚染物質シミュレーションとその健康影響評価(都市における気候変動適応研究の最先端,専門分科会)
五藤 大輔, 中島 映至, 上田 佳代, Chris-Fook-Sheng Ng, 村田 諒, SALSA project Team
大会講演予講集, 105, 431, 431, 社団法人日本気象学会, Jan. 2014, [Peer-reviewed]
Japanese, Scientific journal - The Relationship between Asian Dust Exposure and Ischemic Stroke Incidence in High-Risk Patients
北園 孝成, 上田 佳代, 吾郷 哲朗
エアロゾル研究, 29, 1, 207, 211, 日本エアロゾル学会, Jan. 2014
Japanese, Scientific journal - Exposure Assessment by Light Detection and Ranging for Asian Dust Aerosol in Epidemiological Studies to Investigate Its Health Effects
上田 佳代, 清水 厚, 井上 健一郎
エアロゾル研究, 29, 1, 230, 236, 日本エアロゾル学会, Jan. 2014
Japanese, Scientific journal - C459 大気環境物質のためのシームレス同化システム構築とその応用(都市における気候変動適応研究の最先端,専門分科会)
中島 映至, 今須 良一, 植松 光夫, 高見 昭憲, 五藤 大輔, 打田 純也, 井上 豊志郎, 鶴田 治雄, 三澤 翔大, 村田 諒, Tie Dai, Nick Schutgens, 上田 佳代, Chris-Fook-Sheng Ng, 佐藤 正樹, 佐藤 陽祐, 村上 暁信, 樋口 篤志, SALSAプロジェクトチーム
大会講演予講集, 105, 429, 429, 社団法人日本気象学会, Jan. 2014
Japanese, Scientific journal - Impacts of Aerosols on Human Health in East and Southeast Asia
HONDA Yasushi, NAKAI Satoshi, ONO Masaji, TAMURA Kenji, NITTA Hiroshi, UEDA Kayo
Earozoru Kenkyu, 29, 1, s183, s189, Japan Association of Aerosol Science and Technology, 2014
Japanese, In this article, we give an overview of East Asian epidemiological studies, including part P12 of Grant in-Aid for Scientific Research in Innovative Areas: "Impacts of Aerosols in East Asia on Plants and Human Health." In particular, we focus on "health effects of East and Southeast Asian air pollution." The body of research surveyed can be divided into studies on short-term effects and long-term effects.The short-term effect studies can further be divided into studies on local effects and trans-boundary effects. We reviewed research on Japanese cedar pollen diseases and particulate matter for short-term local effects, and Asian dust and particulate matter for trans-boundary effects. For long-term effects, we reviewed critically some research that utilized existing cohort studies. - Sociogeographic Variation in the Effects of Heat and Cold on Daily Mortality in Japan
Chris Fook Sheng Ng, Kayo Ueda, Ayano Takeuchi, Hiroshi Nitta, Shoko Konishi, Rinako Bagrowicz, Chiho Watanabe, Akinori Takami
JOURNAL OF EPIDEMIOLOGY, 24, 1, 15, 24, Jan. 2014, [Peer-reviewed]
English, Scientific journal - Seasonal variation in the acute effects of ozone on premature mortality among elderly Japanese
Chris Fook Sheng Ng, Kayo Ueda, Hiroshi Nitta, Ayano Takeuchi
ENVIRONMENTAL MONITORING AND ASSESSMENT, 185, 10, 8767, 8776, Oct. 2013, [Peer-reviewed]
English, Scientific journal - An Analysis of High Sulfate Ion Events Observed in Fukuoka and Osaka City in Summer, 2012
TAKAMI Akinori, IREI Satoshi, KIMOTO Takashi, TAKEMURA Toshihiko, HAYASHI Masahiko, HARA Keiichiro, MIYOSHI Takao, UEDA Kayo, SATO Kei, KANEYASU Naoki, YOSHINO Ayako, HATAKEYAMA Shiro
Earozoru Kenkyu, 28, 4, 281, 286, Japan Association of Aerosol Science and Technology, Jan. 2013, [Peer-reviewed]
Japanese, Scientific journal, We observed high sulfate ion concentrations in Fukuoka and Osaka city using an aerosol mass spectrometer and an ion chromatograph method in the end of July, 2012. The mass concentration of sulfate ion reached ca. 35 μg m-3 on 25 July in Fukuoka. The mass concentration of PM2.5 exceeded 50 μg m-3 and that of sulfate ion was between 10and 20 μg m-3 for several hours on 29 July in Osaka. The simulation using Spectral Radiation- Transport Model for Aerosol Species (SPRINTARS) showed that the air mass with a high sulfate ion concentration first covered the Korean peninsula in July 2012 and then spread over the northern part of Kyushu and the Honshu regions of Japan. This indicates that the observed high sulfate ion events were possibly due to the trans-boundary air pollution. Since air pollution with a high sulfate ion concentration potentially causes adverse health effect, the monitoring of trans-boundary air pollution is necessary even in summer. - S13-4 黄砂が喘息,アレルギー疾患に及ぼす影響評価 : 疫学研究における曝露評価をどのように行うか(黄砂の健康への影響,シンポジウム13,第63回日本アレルギー学会秋季学術大会)
上田 佳代, 小田嶋 博, 井上 健一郎, 清水 厚, 新田 裕史
アレルギー, 62, 9, 1204, 1204, 一般社団法人日本アレルギー学会, Jan. 2013
Japanese, Scientific journal - The effects of long-term exposure to particulate matter on cardiovascular diseases
上田 佳代
医学のあゆみ, 247, 8, 678, 683, 医歯薬出版, Jan. 2013
Japanese, Scientific journal - Long-range transported Asian Dust and emergency ambulance dispatches
Kayo Ueda, Atsushi Shimizu, Hiroshi Nitta, Kenichiro Inoue
INHALATION TOXICOLOGY, 24, 12, 858, 867, Oct. 2012, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal - 微小粒子状物質成分が死亡に及ぼす影響 検出下限未満の実測値処理による推定値の違い
上田 佳代, 山神 真紀子, 池盛 文数, 久恒 邦裕, 新田 裕史
日本衛生学雑誌, 67, 2, 284, 284, (一社)日本衛生学会, Feb. 2012, [Peer-reviewed]
Japanese - Health effect of photochemical oxidant - results from 20 cities and overseas trend (in Japanese)
上田 佳代, Ng Chris Fook Sheng, 新田 裕史
Journal of Japan Society for Atmospheric Environment, 47, 1, A9, A11, Japan Society for Atmospheric Environment, Jan. 2012
Japanese, Scientific journal - Exposure to Particulate Matter and Long-term Risk of Cardiovascular Mortality in Japan: NIPPON DATA80
Kayo Ueda, Shin-ya Nagasawa, Hiroshi Nitta, Katsuyuki Miura, Hirotsugu Ueshima
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 19, 3, 246, 254, 2012, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal - Short-Term Exposure to Air Pollution and Incidence of Stroke and Acute Myocardial Infarction in a Japanese Population
Tanvir Chowdhury Turin, Yoshikuni Kita, Nahid Rumana, Yasuyuki Nakamura, Kayo Ueda, Naoyuki Takashima, Hideki Sugihara, Yutaka Morita, Masaharu Ichikawa, Kunihiko Hirose, Hiroshi Nitta, Akira Okayama, Katsuyuki Miura, Hirotsugu Ueshima
NEUROEPIDEMIOLOGY, 38, 2, 84, 92, 2012, [Peer-reviewed]
English, Scientific journal - Ambient Air Pollutants and Acute Case-Fatality of Cerebro-Cardiovascular Events: Takashima Stroke and AMI Registry, Japan (1988-2004)
Tanvir Chowdhury Turin, Yoshikuni Kita, Nahid Rumana, Yasuyuki Nakamura, Kayo Ueda, Naoyuki Takashima, Hideki Sugihara, Yutaka Morita, Masaharu Ichikawa, Kunihiko Hirose, Hiroshi Nitta, Akira Okayama, Katsuyuki Miura, Hirotsugu Ueshima
CEREBROVASCULAR DISEASES, 34, 2, 130, 139, 2012, [Peer-reviewed]
English, Scientific journal - PM2.5各成分が死亡に及ぼす影響評価
上田 佳代, 山神 真紀子, 池盛 文数, 久恒 邦裕, 新田 裕史
大気環境学会年会講演要旨集, 52回, 298, 298, (公社)大気環境学会, Aug. 2011, [Peer-reviewed]
Japanese - The Health Effects of Fine Particulate Matter : Evidence among Japanese populations and trends in epidemiological studies
UEDA Kayo
Journal of Japan Society for Atmospheric Environment / Taiki Kankyo Gakkaishi, 46, 2, A7, A13, Japan Society for Atmospheric Environment, 20 Mar. 2011
Japanese - Effects of Asian Dust Events on Daily Mortality in Nagasaki, Japan
Masahiro Hashizume, Yuji Nishiwaki, Takehiro Michikawa, Kayo Ueda, Daisuke Onozuka, Ken-ichi Yokota, Mariko Mine, Atsuko Mori, Atsushi Shimizu, Nobuo Sugimoto, Taro Yamamoto
EPIDEMIOLOGY, 22, 1, S130, S130, Jan. 2011, [Peer-reviewed]
English - Health effects of Asian dust events: a review of the literature.
Hashizume M, Ueda K, Nishiwaki Y, Michikawa T, Onozuka D
Nippon eiseigaku zasshi. Japanese journal of hygiene, 65, 3, 413, 421, May 2010, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal - Estimating Mortality Effects of Fine Particulate Matter in Japan: A Comparison of Time-Series and Case-Crossover Analyses
Kayo Ueda, Hiroshi Nitta, Masaji Ono, Ayano Takeuchi
JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION, 59, 10, 1212, 1218, Oct. 2009, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal - Effects of Fine Particulate Matter on Daily Mortality for Specific Heart Diseases in Japan
Kayo Ueda, Hiroshi Nitta, Masaji Ono
CIRCULATION JOURNAL, 73, 7, 1248, 1254, Jul. 2009, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal
Other Activities and Achievements
- 低濃度のPM2.5への曝露と急性疾患発生との関係
上田佳代, セポソ サークセス, アタッチャ アティーシャ, アハマッドタジュヂン バシットムハマッドアブドゥル, ウンクリス フックシェン, 橋爪真弘, 岡和孝, 日本疫学会学術総会講演集(Web), 34th, 2024 - Developing a risk function of PM2.5 and Under 5 Child Mortality: A Review.
Wahida Musarrat Anita, Ueda Kayo, 日本公衆衛生雑誌 第80回日本公衆衛生学会総会, 68, 11, 311, 311, Dec. 2021
32891745 - Health risk perception and Awareness of air pollu- tion: Scoping review
Bahrami Zeinab, Yang Zhesi, Onishi Kazunari, Umemura Tomohiro, Ueda Kayo, 日本公衆衛生雑誌 第80回日本公衆衛生学会総会, 68, 11, 311, Dec. 2021
36683955 - Face mask use under the COVID-19 pandemic for farmers in Punjab, India
Yang Zhesi, Ueda Kayo, memura Tomohiro, Onishi Kazunari, 日本公衆衛生雑誌 第80回日本公衆衛生学会総会, 68, 11, 196, Dec. 2021
36683955 - City-specific modifiers of acute PM2.5 and ozone ef- fects on ambulance dispatches
Liang Yuwen, Ueda Kayo, Hashizume Masahiro, 日本公衆衛生雑誌 第80回日本公衆衛生学会総会, 68, 11, 195, Dec. 2021 - 超微小粒子の健康影響に関する文献レビュー
上田佳代, 池田一男, Paoin Kanawat, 梁雨文, 竹川暢之, 伏見暁洋, 藤谷雄二, 桜井博, 村島淑子, 第62回大気環境学会年会講演要旨集, 217, Sep. 2021, [Lead author]
36684140 - Public perception of air pollution and stubble burning—a cross-sectional survey study in Punjab, India
Yang Zhesi, 上田佳代, 梅村朋弘, 大西一成, 寺崎寛章, 松見豊, 中山智喜, 村尾 るみこ, 浅田晴久, 佐藤孝宏, 林田佐智子, 第62回大気環境学会年会講演要旨集, 184, Sep. 2021
36683955 - 日本における感染性胃腸炎の発生と降雨量との関係
山下 慧, 高野 裕久, 上田 佳代, 本田 昌子, 田中 宏明, 日高 平, ザーゼス・セポ, 日本衛生学雑誌, 76, Suppl., S157, S157, Mar. 2021
(一社)日本衛生学会, Japanese - Association between PM[2.5] and Heart rate variability in 3 cities of Japan (京都大学環境衛生工学研究会 第41回 シンポジウム講演論文集)
PAOIN Kanawat, UEDA Kayo, SEPOSO Xerxes Tesoro, HAYANO Junichiro, KIYONO Ken, UEDA Norihiro, KAWAMURA Takashi, TAKANO Hirohisa, 環境衛生工学研究 = Environmental & sanitary engineering research : 京都大学環境衛生工学研究会機関誌, 33, 3, 118, 120, Jul. 2019
京都大学環境衛生工学研究会, English, Report research institution - 日本の21都市におけるオゾンと外来患者の非線形な関連
セポソ サークセス, セポソ サークセス, 上田佳代, 上田佳代, 吉野彩子, 菅田誠治, 高見昭憲, 日本衛生学雑誌(Web), 74, Supplement, S118, Feb. 2019
English, Report scientific journal - 学術研究からの少子化対策 日本衛生学会からの提言に向けて 日本衛生学会における少子化対策提言に向けて 日本衛生学会少子化対策ワーキンググループによるとりまとめ
野村 恭子, 苅田 香苗, 荒木 敦子, 西岡 笑子, 武藤 剛, 岩井 美幸, 錦谷 まりこ, 井上 まり子, 鶴ヶ野 しのぶ, 北野 尚美, 辻 真弓, 飯島 佐知子, 上田 佳代, 上島 通浩, 山縣 然太郎, 坂田 清美, 伊木 雅之, 柳澤 裕之, 加藤 昌志, 横山 和仁, 小泉 昭夫, 大槻 剛巳, 日本衛生学雑誌, 74, 1of5, 5of5, 2019
(一社)日本衛生学会, Japanese - 学術研究からの少子化対策 日本衛生学会からの提言に向けて 日本衛生学会における少子化対策提言に向けて 日本衛生学会少子化対策ワーキンググループによるとりまとめ
野村 恭子, 苅田 香苗, 荒木 敦子, 西岡 笑子, 武藤 剛, 岩井 美幸, 錦谷 まりこ, 井上 まり子, 鶴ヶ野 しのぶ, 北野 尚美, 辻 真弓, 飯島 佐知子, 上田 佳代, 上島 通浩, 山縣 然太郎, 坂田 清美, 伊木 雅之, 柳澤 裕之, 加藤 昌志, 横山 和仁, 小泉 昭夫, 大槻 剛巳, 日本衛生学雑誌, 74, 1of5, 5of5, 2019
(一社)日本衛生学会, Japanese - Health Effects of Asian Dust Events: A Literature Review Update of Epidemiological Evidence
HASUNUMA Hideki, WATANABE Masanari, HASHIZUME Masahiro, ICHINOSE Takamichi, UEDA Kayo, ODAJIMA Hiroshi, KANATANI Kumiko, SHIMIZU Atsushi, TAKAMI Akinori, TAKEUCHI Ayano, NISHIWAKI Yuji, Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene), 74, 0, n/a, 2019, [Domestic magazines]Asian dust is a phenomenon involving the long-range transport of atmospheric pollutants originating from the desert areas of China and Mongolia. In recent years, the health effects of Asian dust have raised public concerns. Numerous studies on the health effects of Asian dust have been published since the last review in 2010. Thus, a literature review was conducted to shed light on the latest epidemiologic findings. PubMed and Science Direct databases were used for the review of epidemiologic studies published between June 2009 and April 2018. We identified 53 epidemiologic studies. Mortality, ambulance transportation, hospitalization/medical examination, changes in symptomatic, functional, and examination findings, as well as birth outcomes have been reported as outcomes. When the outcomes were categorized by disease, the effects of Asian dust on respiratory, cardiovascular, and allergic diseases raised concerns. The common evidences of causation between Asian dust and these diseases were the consistency of findings and temporal sequence of association. As results of research on dose-response relationships have become available, and the possibility that the health effects of Asian dust may vary depending on its chemical composition has been pointed out, further research using the exposure level indicators of Asian dust or its chemical composition should be conducted. Furthermore, with focus on the crucial issue of reducing exposure, research related to prevention and raising awareness should be further promoted.
, The Japanese Society for Hygiene, Japanese - [Health Effects of Asian Dust Events: A Literature Review Update of Epidemiological Evidence].
Hideki Hasunuma, Takamichi Ichinose, Kayo Ueda, Hiroshi Odajima, Kumiko Kanatani, Atsushi Shimizu, Akinori Takami, Ayano Takeuchi, Yuji Nishiwaki, Masanari Watanabe, Masahiro Hashizume, Nihon eiseigaku zasshi. Japanese journal of hygiene, 74, 1 of 16, 16 of 16, 2019, [Domestic magazines]
(一社)日本衛生学会, Japanese - 大気中SPMの経時変化と救急車出動との関連性(Hourly variation in ambient SPM and its association with emergency ambulance dispatches)
Phung Vera Ling Hui, 上田 佳代, Seposo Xerxes, 道川 武紘, 山崎 新, 新田 裕史, 高見 昭憲, 菅田 誠治, 吉野 彩子, 本田 晶子, 高野 裕久, 大気環境学会年会講演要旨集, 59回, 292, 292, Aug. 2018
(公社)大気環境学会, English, Report scientific journal - Impact of Global Change in Sulfur Dioxide, Black Carbon and Organic Carbon on PM2.5-Related Premature Mortality and Years Life Lost
Seposo, XT, Ueda, K, Park, SS, Sudo K, Takemura, T, Nakajima, T, Environmental Health Perspective, Aug. 2018
English, Report scientific journal - PM2.5の健康影響―身近な疑問から最新の研究結果まで―
上田佳代, XERXES Seposo, 大気環境学会年会講演要旨集, 59th, 204‐205, Aug. 2018
Japanese, Report scientific journal - Effects of ambient PM<sub>2.5</sub> and ozone on outpatient asthma visits in 21 Japanese Cities
SEPOSO Xerxes, SEPOSO Xerxes, UEDA Kayo, UEDA Kayo, SUGATA Seiji, YOSHINO Ayako, TAKAMI Akinori, 大気環境学会年会講演要旨集, 59th, 359, Aug. 2018
English, Report scientific journal - Effect of streamer plasma irradiation on ambient PM2.5-induced pro-inflammatory responses in human bronchial epithelial cells.
Tanaka T, Tamura S, Honda A, Tanaka M, Okano H, Onishi T, Takai S, Wang Z, Ueda K, Takano H, IndoorAir2018, Jul. 2018
English, Summary international conference - Health effect of air pollution in Thailand: Recent research development and challenges.
Phosri A, Ueda, K, Honda A, Takano H, ISEE-AC, Jun. 2018
English, Summary international conference - 埼玉県における大量の降雨が感染性胃腸炎の発生件数に与える影響
金藤一路, 上田佳代, 小谷和也, セポソ サークセス, 本田晶子, 高野裕久, 日本衛生学雑誌(Web), 73, Supplement, S227, Mar. 2018
Japanese, Report scientific journal - 長崎での黄砂が小児気管支喘息患者へ及ぼす影響
中村 孝裕, 西脇 祐司, 森内 浩幸, 上田 佳代, 清水 厚, 竹内 文乃, 橋爪 真弘, 日本衛生学雑誌, 73, Suppl., S268, S268, Mar. 2018
(一社)日本衛生学会, Japanese - 長崎での黄砂が小児気管支喘息患者へ及ぼす影響
中村 孝裕, 西脇 祐司, 森内 浩幸, 上田 佳代, 清水 厚, 竹内 文乃, 橋爪 真弘, 日本衛生学雑誌, 73, Suppl., S268, S268, Mar. 2018
(一社)日本衛生学会, Japanese - 長崎での黄砂が小児気管支喘息患者へ及ぼす影響
中村孝裕, 西脇祐司, 森内浩幸, 上田佳代, 清水厚, 竹内文乃, 橋爪真弘, 日本衛生学雑誌(Web), 73, Supplement, S268, Mar. 2018
Japanese - 夏季の高気温が救急搬送数に与える影響：年齢別の検討
小谷和也, 上田佳代, サークセス セポソ, 安河内秀輔, 松本弘子, 小野雅司, 本田晶子, 高野裕久, 第88回日本衛生学会学術総会, Mar. 2018
Japanese - 光化学オキシダントと急病による救急搬送との関連：複数都市における疾患別検討
長谷川博史, 上田佳代, 本田晶子, 高野裕久, 第88回日本衛生学会学術総会, Mar. 2018
Japanese - 埼玉における極端な降雨が感染性胃腸炎の発生件数に与える影響
金藤一路, 上田佳代, 小谷和也, Seposo Xerxes Tesoro, 本田晶子, 高野裕久, 第88回日本衛生学会学術総会, Mar. 2018
Japanese - Effects of ambient PM2.5 collected from Asian cities using cyclone technique on human airway epithelial cells
Chowdhury,P H, Honda,A, Ito,S, Okano,H, Onishi,T, Higashihara,M, Tanaka, T, Hirai,S, Ueda,K, Takano,H, 第58回大気環境学会年会, Sep. 2017
English - 福岡におけるPM2.5の化学成分と小学生の症状との関連
杉山太一, 上田佳代, 中島亜矢子, 木下誠, 小川貴史, 藤本正典, 道川武紘, 新田裕史, 第58回大気環境学会年会, Sep. 2017
Japanese - Short-term exposure to air pollution and daily hospital admissions for acute myocardial infarction in Bangkok, Thailand
Phosri A, Ueda K, Phung V.L.H, Yasukouchi S, Sugiyama T, Paoin K, Kotani K, Hasegawa H, Honda A, Takano H, Conference of ISEE 2017, Sep. 2017
English, Summary international conference - Association between short-term exposure to ambient ozone and PM2.5 and health effects among Japanese adults in different regions in Japan.
Phung V.L.H, Ueda K, Phosri A, Hasegawa H, Sugiyama T, Paoin K, Seposo X T, Honda A, Takano H, Conference of ISEE 2017, Sep. 2017
English, Summary international conference - Determining the concentration‐response risk function of daily PM<sub>2.5</sub> concentration on daily all‐cause mortality from the 9 cities in Japan: An application of penalized Distribute Lag Non‐Linear Model
SEPOSO Xerxes, MICHIKAWA Takehiro, NITTA Hiroshi, YAMAZAKI Shin, UEDA Kayo, 大気環境学会年会講演要旨集, 58th, 240, Aug. 2017
English, Report scientific journal - トリクロロエチレン健康リスク評価作業部会報告書 トリクロロエチレンに係る健康リスク評価について
青木 康展, 上田 佳代, 内山 巌雄, 上島 通浩, 祖父江 友孝, 武林 亨, 中杉 修身, 那須 民江, 新田 裕史, 野見山 哲生, 山崎 新, 朝倉 敬子, 苅田 香苗, 塚原 照臣, 中野 真規子, 道川 武紘, 安達 修一, 高野 裕久, 中島 宏, トリクロロエチレン健康リスク評価作業部会, 大気環境学会誌, 52, 2, A24, A57, Mar. 2017
(公社)大気環境学会, Japanese - 福岡におけるPM2.5の化学成分濃度と小学生の有症率との関連
杉山太一, 上田佳代, 中島亜矢子, 木下誠, 小川貴史, 藤本正典, 道川武紘, 新田裕史, 本田晶子, 高野裕久, 第87回日本衛生学会学術年会, Mar. 2017
Japanese - 気温の救急搬送数に対する影響は年齢により異なる
小谷和也, 上田佳代, 安河内秀輔, 本田晶子, 高野裕久, 第87回日本衛生学会学術年会, Mar. 2017
Japanese - 大阪市における光化学オキシダントと救急搬送との関連
長谷川博史, 上田佳代, 本田晶子, 高野裕久, 第87回日本衛生学会学術年会, Mar. 2017
Japanese - Short-term exposure to ambient particulate matter and emergency ambulance dispatch for acute illness in Japan
Saira Tasmin, Kayo Ueda, Andrew Stickley, Shinya Yasumoto, Vera Ling Hui Phung, Mizuki Oishi, Shusuke Yasukouchi, Yamato Uehara, Takehiro Michikawa, Hiroshi Nitta, SCIENCE OF THE TOTAL ENVIRONMENT, 566, 528, 535, Oct. 2016
English - 大気エアロゾル中の水溶性成分濃度と急病による救急搬送数との関連
上原大和, 上田佳代, 林政彦, 原圭一郎, Saira Tasmin, 大石瑞貴, Arthit Phosri、Vera Phung Ling Hui, 安河内秀輔, 本田晶子, 高野裕久, 第57回大気環境学会年会, Sep. 2016
Japanese - 暑熱環境下での体感温度と急病による救急搬送数の相関
安河内秀輔, 上田佳代, Tasmin Saira, 大石瑞貴, Arthit Phosri, Phung Vera Ling Hui, 上原大和, 本田晶子, 高野裕久, 第57回大気環境学会年会, Sep. 2016
Japanese - Association between PM2.5 and hospitalization due to asthma for children and adolescent: exploring susceptibility factors
Ueda,K, Oishi,M, Odashima,H, Tasmin,S, Phung,V.L.H, Yasukouchi,S, Uehara,Y, Honda,A, Takano,H, 第26回国際喘息学会日本・北アジア部会, Sep. 2016
English, Summary international conference - Effects of Benzo(a)pyrene, 9,10-phenanthraquinone and 1,2-napthoquinone on respiratory and immune responses.
Chowdhury,PH, Kitamura,G, Honda,A, Sawahara,T, Hayashi,T, Fukushima,W, Kudou,H, Ito,S, Ueda,K, Takano,H, 第38回 京都大学環境衛生工学研究会シンポジウムプログラム, 30, 3, 180, 183, Jul. 2016
京都大学環境衛生工学研究会, English - Short-term exposure to ambient fine particulate matter (PM2.5) on emergency ambulance dispatches due to acute illnesses in Japan: A multi-city study
Phung,V.L.H, Ueda,K, Tasmin,S, Ooishi,M, Yasukouchi,S, Uehara,Y, Phosri,A, Honda,A, Takano,H, Conference of ISEE-ISES AC2016, Jun. 2016
English, Summary international conference - Specific fine particulate matter compositions enhanced the association between airborne pollen and daily consultations for pollinosis in Fukuoka, Japan
Phosri,A, Ueda,K, Tasmin,S, Ooishi,M, Phung,V.L.H, Yasukouchi,S, Uehara,Y, Honda,A, Takano,H, Conference of ISEE-ISES AC2016, Jun. 2016
English, Summary international conference - 黄砂が小児気管支喘息患者へ及ぼす影響に関する研究(第一報 研究デザイン)
中村孝裕, 西脇祐司, 橋本邦生, 森内浩幸, 北島翼, 小森一広, 田代香澄, 上田佳代, 清水厚, 竹内文乃, 久保達彦, 小田嶋博, 橋爪真弘, Journal of Epidemiology (Web), 26, Supplement 1, 141, 21 Jan. 2016
Japanese - Health effects of long-term exposure to PM2.5 and mortality: a systematic review
Ueda,K, Tasmin,S, Oishi,M, Phung,V.L.H, Yasukochi,S, Uehara,Y, Honda,A, Takano,H, 第26回日本疫学会学術総会, Jan. 2016 - Seasonal modification in the effects of acute exposure to outdoor particulate matter on emergency ambulance dispatch due to acute illness in Japan
Tasmin,S, Ueda,K, Phung,V.L.H, Ooishi,M, Yasukouchi,S, Honda,A, Takano,H, Third International Conference on Global Public Health 2015, Dec. 2015
English, Summary international conference - 九州北部におけるPM2.5の化学成分別分析
三澤健太郎, 吉野彩子, 高見昭憲, 小島知子, 村野健太郎, 畠山史郎, 坂本哲夫, 上田佳代, 道川武紘, 新田裕史, 大気環境学会年会講演要旨集, 56th, 154, 155, 04 Sep. 2015
Japanese - PM2.5の短期曝露と急病による救急搬送との関連 複数都市における検討
上田 佳代, 笠岡 俊志, Tasmin Saira, 道川 武紘, 新田 裕史, 吉野 彩子, 三澤 健太郎, 高見 昭憲, 大気環境学会年会講演要旨集, 56回, 462, 462, Sep. 2015
(公社)大気環境学会, Japanese - 食品成分がDEPによる気道炎症に及ぼす影響の評価
伊藤翔, 澤原隆紘, 林智裕, 福嶋渉, 北村岳, 工藤仁美, 本田晶子, 上田佳代, 高野裕久, 第22回日本免疫毒性学会, Sep. 2015
Japanese - 黄砂に付着する生物的・化学的成分が呼吸器・免疫系に及ぼす影響
本田晶子, 澤原隆紘, 林智裕, 辻堅志, 福嶋渉, 大石瑞貴, 北村岳, 工藤仁美, 伊藤翔, 吉田成一, 市瀬孝道, 上田佳代, 高野裕久, 第22回日本免疫毒性学会, 22nd, Sep. 2015
Japanese - 福岡におけるPM2.5濃度と小児の喘息による入院との関連
大石瑞貴, 上田佳代, 小田嶋博, Tasmin Saira, Phung Vera Ling Hui, 安河内秀輔, 上原大和, 本田晶子, 高野裕久, 第56回大気環境学会, Sep. 2015
Japanese - Acute Illnesses due to the Lagged Effects of Ambient Particulate Matter.
Phung,V.L.H, Ueda,K, Tasmin,S, Ooishi,M, Yasukouchi,S, Uehara,Y, Honda,A, Takano,H, 37th Symposium of The Association of Environmental & Sanitary Engineering Research, 29, 3, 31, 34, Jul. 2015
京都大学環境衛生工学研究会, English - Emergency Ambulance Dispatches due to Acute Illness and Ambient Particulate Matter
Vera Ling Hui Phung, Kayo Ueda, Saira Tasmin, Mizuki Ooishi, Yasukouchi Shusuke, Akiko Honda, Hirohisa Takano, 9th Asian Aerosol Conference, Jun. 2015
English, Summary international conference - Journal of Epidemiology
Kayo Ueda, Makiko Yamagami, Fumikazu Ikemori, Kunihiro Hisatsune, Hiroshi Nitta, 第25回日本疫学会学術総会講演集, 25, Sup1, 88, Jan. 2015, [Peer-reviewed]
English, Summary national conference - Asian Dust Has an impact on the Incidence of Acute Myocardial Infarction similar to a Time-stratified Case-crossover Study
Sunao Kojima, Kunihiko Matsui, Kayo Ueda, Hiroshi Nitta, Hisao Ogawa, CIRCULATION, 130, Nov. 2014
English, Summary international conference - 気温が急病による救急搬送数に及ぼす影響：6都市における検討
上田佳代, 道川武紘, 新田裕史, 第73回日本公衆衛生学会総会抄録集, 61, 10, 608, Nov. 2014
Japanese, Summary national conference - PM2.5成分が呼吸器系・免疫細胞に及ぼす影響の検討
福嶋渉, 大石瑞貴, 本田晶子, 辻堅志, 澤原隆紘, 林智裕, 工藤仁美, 上田佳代, 高野裕久, 第21回日本免疫毒性学会学術年会, Sep. 2014
Japanese - 微小粒子状物質(PM2.5)が死亡に及ぼす影響の季節変動
上田佳代, 第55回大気環境学会年会講演要旨集, 351, Sep. 2014
Japanese - PM2.5成分が免疫担当細胞に及ぼす影響
本田晶子, 辻堅志, 大石瑞貴, 工藤仁美, 澤原隆紘, 林智裕, 福嶋渉, 上田佳代, 高野裕久, 第23回日本臨床環境医学会, Jun. 2014
Japanese - 関東におけるオゾン関連死亡数の推定
上田佳代, Ng Chris Fook Sheng, 五藤大輔, 有賀敏典, 松橋啓介, Tasmin Saira, 高見昭憲, 第85回日本衛生学会学術総会講演集, 70, S202, May 2014
Japanese, Summary national conference - Future prediction of ambulance dispatches due to heatstroke in Kanto region
Kayo Ueda, Japanese Journal of Hygiene, 69, Supplement, S235, May 2014
Japanese - The Association between Asian Dust and Mortality
橋爪真弘, 西脇祐司, 道川武紘, 上田佳代, 横田賢一, 三根眞理子, 森淳子, 清水厚, 杉本伸夫, エアロゾル研究, 29, S1, S225-S229 (J-STAGE), s229, 2014
There is increasing concern for possible adverse health effects of Asian dust. In this paper, we reviewed the epidemiological evidence of potential effects of Asian dust events on mortality, from six studies retrieved from PubMed. In addition, one study was identified through a manual search of conference proceedings and reports. Three studies were conducted in Seoul, two in Taipei, and the remaining two in Japan. In Seoul, statistically significant effects of Asian dust on all-cause and circulatory mortality among people 65 years of age or over and respiratory mortality among general population were reported.In Taipei, one study reported a significant effect on cardiovascular mortality and another study reported no significant effect on all-cause and cause-specific mortality. A study of 47 cities in western Japan reported a significant increase in circulatory and respiratory mortality with the increase in Asian dust particles, while no evidence of effects on mortality was reported in the study conducted in Nagasaki., Japan Association of Aerosol Science and Technology, Japanese - 長崎県五島市における熱中症予防ランダム化地域比較介入研究
古尾谷法子, 中尾理恵子, 上田佳代, 近藤正英, 本田靖, 橋爪真弘, 日本公衆衛生学会総会抄録集, 72回, 610, 610, Oct. 2013
日本公衆衛生学会, Japanese - 夏季における気温と室内温度との関係:空調使用の影響
上田佳代, 小野雅司, 本田靖, 橋爪真弘, 山本太郎, 日本衛生学雑誌, 68, Suppl., S203, S203, Mar. 2013
(一社)日本衛生学会, Japanese - ウツタイン統計を用いた黄砂の健康影響に関する調査研究
西脇祐司, 上田佳代, 久保達彦, 清水厚, 橋爪真弘, 岡村智教, J Epidemiol, 23, Supplement 1, 106, 24 Jan. 2013
Japanese - 熱中症予防情報の家庭配信による行動意識変容―長崎県五島市における介入研究―
古尾谷法子, 中尾理恵子, 上田佳代, 近藤正英, 小野雅司, 本田靖, 橋爪真弘, 日本国際保健医療学会学術大会プログラム・抄録集, 27th, 131, 02 Nov. 2012
Japanese - 長崎県五島市における熱中症予防ランダム化地域比較介入研究
古尾谷法子, 中尾理恵子, 上田佳代, 近藤正英, 小野雅司, 本田靖, 橋爪真弘, 日本公衆衛生学会総会抄録集, 71回, 577, 577, Oct. 2012
日本公衆衛生学会, Japanese - 地球温暖化に伴う熱中症の被害予測 (2010年夏 日本の猛暑) -- (予測)
小野 雅司, 上田 佳代, 気象研究ノート, 225, 177, 182, May 2012
日本気象学会, Japanese - 1G1600-4 Health effects of fine particles and its composition: Assessment using epidemiological methods and challenges(Generation of particles in the urban atmosphere and its health effects,7: Health Effect Subcommittee and Urban Aerosol Subcommittee,Subcommittee Meetings)
UEDA Kayo, 大気環境学会年会講演要旨集, 53, 167, 167, 2012
大気環境学会, Japanese - 1A1039 A study design of 3-year cohort study of air pollution and lung function growth among school children(3 Effect-1 biology,General Presentations)
UEDA Kayo, 大気環境学会年会講演要旨集, 53, 180, 180, 2012
大気環境学会, Japanese - P-90 A study design of 3-year cohort study of air pollution and lung function growth among schoolchildren(Poster session)
TAKEBAYASHI Toru, ASAKURA Keiko, NITTA Hiroshi, TAKEUCHI Ayano, UEDA Kayo, ODAJIMA Hiroshi, HASEGAWA Shuichi, TSUKAHARA Teruomi, KONNO Satoshi, MORIKAWA Miki, MUKAI Yasufumi, YOSHIMURA Takesumi, 大気環境学会年会講演要旨集, 53, 320, 320, 2012
大気環境学会, Japanese - 黄砂の短期曝露による死亡への影響:6市における検討
上田佳代, 橋爪真弘, 西脇祐司, 清水厚, 西川雅高, 日本衛生学雑誌, 66, 2, 386, 386, Feb. 2011
(一社)日本衛生学会, Japanese - The Effect of Asian Dust Aerosol on Emergency Visits
Kayo Ueda, Hiroshi Nitta, Kenichiro Inoue, EPIDEMIOLOGY, 22, 1, S221, S222, Jan. 2011
English, Summary international conference - Long-term Exposure to Particulate Matter and Cardiovascular Mortality in a Representative Japanese Cohort: NIPPON DATA80
Kayo Ueda, Shinya Nagasawa, Hiroshi Nitta, Katsuyuki Miura, Hirotsugu Ueshima, EPIDEMIOLOGY, 22, 1, S79, S79, Jan. 2011
English, Summary international conference - The effects of weather, air pollutants, and Asian dust on hospitalization for asthma in Fukuoka
UEDA Kayo, NITTA Hiroshi, ODAJIMA Hiroshi, Environ Health Prev Med, 15, 6, 350, 357, 01 Nov. 2010
English - 黄砂の健康影響 疫学文献レビュー
橋爪 真弘, 上田 佳代, 西脇 祐司, 道川 武紘, 小野塚 大介, 日本衛生学雑誌, 65, 3, 413, 421, May 2010
(一社)日本衛生学会, Japanese - 大気中粒子の長期曝露と心血管疾患死亡との関連 NIPPON DATA80による検討
上田 佳代, 長澤 晋哉, 新田 裕史, 三浦 克之, 上島 弘嗣, 日本衛生学雑誌, 65, 2, 305, 305, Apr. 2010
日本衛生学会, Japanese - 黄砂の健康影響―疫学文献レビュー
橋爪真弘, 上田佳代, 西脇祐司, 道川武紘, 小野塚大介, 日本衛生学雑誌, 65, 2, 306, 306, Apr. 2010
(一社)日本衛生学会, Japanese - Specific Chemical Components of Particulate Matter and Daily Mortality in a Japanese Urban City
Kayo Ueda, Hiroshi Nitta, Norio Ito, Akua Mizohata, EPIDEMIOLOGY, 20, 6, S146, S146, Nov. 2009
English, Summary international conference - Effects of Fine Particulate Matter on Daily Mortality for Specific Heart Diseases in Japan (vol 73, pg 1248, 2009)
Kayo Ueda, Hiroshi Nitta, Masaji Ono, CIRCULATION JOURNAL, 73, 10, 1972, 1972, Oct. 2009
English, Others - P-46 Specific chemical components of particulate matter and daily mortality in Sakai(Poster session)
UEDA Kayo, NITTA Hiroshi, ITO Norio, MIZOHATA Akira, 大気環境学会年会講演要旨集, 50, 338, 338, 2009
大気環境学会, Japanese
Books and other publications
- Chapter 7. Epidemiological approaches to characterize human health risks from environmental exposure in a watershed. In Environmental Risk Analysis for Asian Oriented Risk Based Watershed Management
Kayo Ueda, Hirohisa Takano
Springer, Singapore, 2018, [Joint work] - Annual Review 呼吸器2015 II. 4. PM2.5と呼吸器疾患
上田佳代, 新田裕史
中外医学社, Jan. 2015, [Contributor] - Overcoming Environmental Risks to Achieve Sustainable Development Goals Lessons from the Japanese Experience
Yokkaichi Asthma: Health Effects of Air Pollutants in Japan
Springer, 9789811662492, [Contributor]
Lectures, oral presentations, etc.
- 成分データを活用した疫学研究：国内知見と今後の展開
上田佳代
第62回大気環境学会年会, 21 Sep. 2021, Nominated symposium
[Invited] - Health Effect of Air Pollution: A case study from Japan
Kayo Ueda
IAPSMCON2021, CME on Basics of Health Risk Assessment, 16 Mar. 2021, English, Invited oral presentation - Global Health Benefit by Reducing PM2.5 Level
Ueda K, Seposo X, Nakata M, Hanaoka T, Sudo K, Takemura T
2019 Conference of the International Society for Environmental Epidemiology and International Society of Exposure Science- Asia Chapter, Nominated symposium
17 Oct. 2019 - 19 Oct. 2019, 13712130, [Invited]
Affiliated academic society
Research Themes
- 難病データベースとイオンビーム工学技術を応用した全身性強皮症の病態解明
科学研究費助成事業
01 Apr. 2024 - 31 Mar. 2028
古賀 康彦, 木田 節, 熊谷 貴美代, 石見 拓, 上田 佳代
日本学術振興会, 基盤研究(C), 群馬大学, 24K11594 - Air Pollution from Peatland Fires and Effects on Cognitive and Pulmonary Function for Highly Exposed Population
Grants-in-Aid for Scientific Research
08 Sep. 2023 - 31 Mar. 2027
上田 佳代, 戸野倉 賢一, 松島 理明, 大橋 勝文, アタッチャ アティーシャ, 内藤 大輔
Japan Society for the Promotion of Science, Fund for the Promotion of Joint International Research (International Collaborative Research), Hokkaido University, 23KK0165 - Epidemiological and toxicological studies to evaluate the spatio-temporal distribution of ultrafine particles and their acute effects on olfaction and the central nervous system
Grant-in-Aid for Scientific Research (A)
Apr. 2024 - Mar. 2027
高見 昭憲, 吉野 彩子, 藤谷 雄二, 伏見 暁洋, 菅田 誠治, 森野 悠, Tin・Tin Win・Shwe, 宇田川 理, 道川 武紘, 上田 佳代, 本間 明宏
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), National Institute for Environmental Studies, 24H00763 - Health effects of low-concentration, non-urban air pollution: health impacts of ship emission controls
Grants-in-Aid for Scientific Research
01 Apr. 2023 - 31 Mar. 2026
上田 佳代, 須崎 純一, 橋爪 真弘, ウン クリス・フック・シェン, SEPOSO XERXES, 木村 優介
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 23H03158 - Research on the effects of extreme events on heat health and adaptation measures
Environment Research and Technology Development FUnd
Apr. 2023 - Mar. 2026
Environmental Restration and Conservation Agency of Japan, National Institute for Environmental Studies, Coinvestigator - Health impacts assessment of short-lived climate forceres
Environment Research and Technology Development Fund
Apr. 2021 - Mar. 2026
Karo Ueda, Seposo Xerxes, Muhammad Abdul Basit Ahmad Tajudin
Environmental Restoration and Conservation Agency, 北海道大学, Principal investigator - An Interdisciplinary Study toward Clean Air, Public Health and Sustainable Agriculture: The Case of Crop Residue Burning in North India
Research Institute for Humanity and Nature Research Project
Mar. 2025
Research Institute for Humanity and Nature Research Project - Spatio-temporal assessment of the health effects of air pollution and its related effect modifiers using satellite data
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
01 Apr. 2020 - 31 Mar. 2023
上田 佳代, 橋爪 真弘, 須崎 純一, ウン クリス・フック・シェン, SEPOSO XERXES
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Kyoto University, 20H03942 - 国際民間航空機関の規制に対応した航空機排出粒子状物質の健康リスク評価と対策提案
環境研究総合推進費
Apr. 2019 - Mar. 2023
竹川 暢之
Environmental Restoration and Conservation Agency - Health effects of PM2.5 and its composition on arrhythmia and heart rate variability
Grants-in-Aid for Scientific Research
01 Apr. 2016 - 31 Mar. 2020
Ueda Kayo
In order to evaluate the effects of PM2.5 exposure on autonomic nervous system, we used the data of Allostatic State Mapping by Ambulatory ECG Repository （ALLSTAR）study which includes the data of heart rate variability(HRV) obtained by Holter ECG in the several prefectures, and combined with PM2.5 concentration. HRV reflects the balance of autonomic nervous system.
In the statistical analysis, we found that higher PM2.5 concentration was associated with lower HRV indices, which could increase the risk of cardiovascular diseases and sudden deaths. The association persisted for a few days. This study elucidated the mechanism by which exposure to ambient particulate air pollution trigger cardiovascular disease through autonomic nervous system by epidemiological approaches.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Kyoto University, 16K09097 - インドネシア熱帯泥炭火災からの大気汚染物質曝露による健康インパクトの包括的評価
国際共同研究加速基金(国際共同研究強化(B))
2018 - 2020
戸野倉賢一
文部科学省, Competitive research funding - 微小(PM2.5)及び粗大粒子状物質が脳卒中発症や死亡に及ぼす短期曝露影響に関する研究
環境研究総合推進費
2017 - 2019
高見昭憲
環境再生保全機構, Competitive research funding - 粒子状物質成分曝露が心電図変化と生命予後に及ぼす影響に関する研究
科学研究費補助金・基盤研究(C)
2016 - 2019
早野順一郎、植田典浩、清野健
文部科学省, Principal investigator, Competitive research funding - 短寿命大気汚染物質による気候変動に伴う健康へのインパクト評価
環境研究総合推進費・委託費S12-3-3
2014 - 2019
上田佳代
環境再生保全機構, Principal investigator, Competitive research funding - The effects of transboundary particulate matter components on the ncidence of cardiovascular diseases
Grants-in-Aid for Scientific Research
01 Apr. 2012 - 31 Mar. 2015
NITTA hiroshi, TAKAMI Akinori, MORINO Yu, KITAZONO Takanari, KAMOUCHI Masahiro, UEDA Kayo, MICHIKAWA Takehiro, YAMAMOTO Yusuke, YOSHINO Ayako
We observed chemical composition of fine aerosol in Fukuoka City and Fukue Island, and classified them with PM2.5 mass concentration and oxygenated state of organic aerosol. In Fukuoka City, local aerosol was significant under low PM2.5 condition, while long-rage transported aerosol was significant under high PM2.5. Fukuoka City is influenced by both long-range transported and local aerosol. We also conducted atmospheric simulation to estimate contributions of transboundary pollution to PM2.5 concentrations in northern Kyusyu in 2012 and found that foreign emission sources had higher contributions than domestic sources.
Finally, we combined the information on the onset of cardiovascular diseases and air pollutants data obtained from monitoring and simulation to conduct epidemiological studies. We found that exposure to particles and Asian dust increase the risk of cardiovascular diseases.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), National Institute for Environmental Studies, 24310024 - 大陸に由来するアジアンスモッグ(煙霧)の疫学調査と実験研究による生体影響解明
科学研究費補助金・基盤研究(A)
2013 - 2015
市瀬孝道
文科省, Competitive research funding - Environmental epidemiologic investigation of the influence of Asian sand on allergy symptoms
Grants-in-Aid for Scientific Research
2011 - 2013
AKAHANE Manabu, IMAMURA Tomoaki, TAKANO Hirohisa, UEDA Kayo, SHIMIZU Atsusi
Using the health survey system through the Internet which we established, allergic symptoms were collected every day and analyzed relation with Asian sand quantity. We analyzed the relation of each symptom and Asian sand quantity by generalized estimating equations with the existence or non-existence of each symptom as dependent variable and sexuality of the object, age and the highest temperature, humidity, pollen quantity, Asian sand quantity on each investigation day as covariant. The present study revealed that frequency of allergic symptoms such as snot, cough, sneeze and itch of eyes were 25, 8, 16 and 17%, respectively. The Asian sand quantity was strongly related to the symptom such as the snot, the cough and itch of eyes. It was also proved that the pollen quantity was related to the sleeplessness among pollinosis patients.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Nara Medical University, 23510033 - Impacts of aerosols in East and Southesst Asia on human health
Grants-in-Aid for Scientific Research
2008 - 2012
HONDA Yasushi, NAKAI Satoshi, ONO Masaji, TAMURA Kenji, NITTA Hiroshi, UEDA Kayo
This study aimed to evaluate the impact of aerosol on East Asia, especially on mortality with epidemiological method. We collected data on particulate matter concentration in major cities in Japan, Korea and Taiwan. We observed the influence of transboundary pollution on the particulate matter concentration in Kyushu area such as Fukuoka, but the influence was small in Tokyo. Effect on mortality was not significant, but Fukuoka tended to have higher mortality.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), University of Tsukuba, 20120013 - 黄砂エアロゾルが救急外来受診に及ぼす影響の疫学的検討
科学研究補助金 新学術領域研究（公募研究）
2009 - 2010
上田佳代
本研究は、黄砂の健康に対する急性影響を評価するために、長崎において、越境汚染の指標である黄砂飛来と救急外来受診との関連について明らかにすることを目的とした。
予備調査として、文献レビューおよび、福岡における呼吸器疾患のデータを用いた解析を行い、それらの結果を論文として学術雑誌に投稿した。文献レビューにおいては、黄砂の健康影響に関するエビデンスが十分でなく、今後の課題として論じた。
本調査として、平成22年度には、長崎市救急実態調査の救急搬送データ、長崎市内の5か所から得た大気汚染物質濃度データ、を用いた解析を行ったところ、SPM濃度上昇により、呼吸器疾患による救急搬送との間に有意な正の関連を認めた。
一方、黄砂の健康影響評価にあたり、黄砂日について異なる指標を用いた解析を行った。目視による黄砂判定を用いた解析では、救急搬送の前日、2日前、3日前が黄砂日であった場合のリスクは上昇し、救急搬送当日から3日前までの間いずれかの日に黄砂日があった場合の救急搬送リスク変化率は、4.3%(95%CI : -0.7,9.5)であった。ライダー観測による黄砂消散係数に基づいて判定された黄砂日における救急搬送リスクを評価するために、高度120mにおける黄砂消散係数の値が閾値(0.13/km)を越えた日を黄砂日とし、非黄砂日に比較した黄砂日の救急搬送リスクの変化率を算出したところ、黄砂曝露による救急リスクは10.2%(95%CI : 0.6,20.6)上昇したことを見出し、黄砂消散係数を用いた黄砂判定による健康影響評価の有用性を明らかにした。さらに、後方流跡線解析の結果により黄砂日を分類し、救急搬送リスクの大きさについて比較したところ、工業地帯を通過した黄砂粒子の曝露により、救急搬送リスクが上昇する可能性を示した。
文部科学省, 新学術領域研究(研究領域提案型), 独立行政法人国立環境研究所, Principal investigator, Competitive research funding, 21120511
