Impact of Snowfall on Ambulance Response Times to Out-of-Hospital Cardiac Arrest ― Nationally-Representative Population-Based Registry Analysis, 2009–2019 ―
Hirokuni Wataki, Xerxes Tesoro Seposo, Athicha Uttajug, Toshihisa Anzai, Isao Yokota, Kayo Ueda, Naohiro Yonemoto, Yoshio Tahara, Tetsuya Matoba, Takanori Ikeda
Circulation Reports, Japanese Circulation Society, 2026年02月11日
研究論文（学術雑誌）

High ground level ozone amplifies heat-related illnesses in Japan: a nationally representative analysis
Mustakim, Muhammad Abdul Basit Ahmad Tajudin, Xerxes Seposo, Asuna Arai, Satoru Chatani, Hikari Shimadera, Shin Araki, Kayo Ueda
Environmental Research Communications, 2026年02月01日
研究論文（学術雑誌）

Impact of heavy rainfall on ambulance response time in Japan.
Athicha Uttajug, Xerxes Seposo, Muhammad Abdul Basit Ahmad Tajudin, Kayo Ueda
Scientific reports, 2025年12月18日, ［国際誌］
英語, 研究論文（学術雑誌）

Perceptions of air pollution from stubble burning and its health risks in Punjab, India.
Zhesi Yang, Kayo Ueda, Tomohiro Umemura, Kazunari Onishi, Hiroaki Terasaki, Tomoki Nakayama, Yutaka Matsumi, Kamal Vatta, Hikaru Araki, Sachiko Hayashida, Prabir K Patra
Scientific reports, 15, 1, 37455, 37455, 2025年10月27日, ［国際誌］
英語, 研究論文（学術雑誌）, In the state of Punjab, India, where a rice-wheat double cropping system is prevalent, smoke from paddy stubble burning deteriorates air quality in the area and downwind regions. To assess citizens' perception about air pollution, its health risks, and attitude toward stubble burning, a semi-structured interview was conducted with 2202 households in 22 districts of Punjab between August 2020 and January 2021. We explored household- and district-specific factors affecting each dimension of health risk perception using the random-intercept logistic regression model. Among all households, 46% of respondents perceived air pollution in Delhi as "severe" while only 25% perceived that in Punjab areas as "severe". Although 60% of respondents noted that smoke from stubble burning did not affect their health or that of their families, more than 65% considered stubble burning to be a major issue. Respondents whose family members have health issues or who are aware of the health risks of air pollution were more likely to perceive smoke from stubble burning is harmful to health. Our findings suggest that while households are aware of the poor air quality in Delhi, they did not recognize stubble burning to be the main cause - in part due to lack of observational evidence.

Effects of smoke haze on respiratory clinic visits in Central Kalimantan, Indonesia according to different haze characteristics.
Vera Ling Hui Phung, Kayo Ueda, Nina Yulianti, Masafumi Ohashi, Masahiro Kawasaki, Fatmaria Fatmaria, Syamsul Arifin, Donna Novina Kahanjak, Ravenalla Abdurrahman Al Hakim Sampurna Putra S, Abi Bakring, Kitso Kusin, Daisuke Naito
International journal of epidemiology, 54, 6, 2025年10月14日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Smoke haze is a common air-pollution issue in Southeast Asia. Studies have suggested an elevated respiratory risk due to smoke-haze exposure. However, relevant studies have applied different exposure assessments in addressing haze effects and there is no unified definition of haze due to differences in its characteristics by location. The present study aimed to examine the effects of haze on respiratory health outcomes by analysing local fire activity and duration. METHODS: Data for daily respiratory visits in Central Kalimantan were collected at local primary healthcare centers ('puskesmas') during the period spanning 2015-2019, encompassing two major haze episodes in the region. Particulate matter with aerodynamic diameter <10 μm and fire hotspot counts were used to determine haze days, including fire-haze and non-fire-haze days. A space-time-stratified case-crossover design was used through a conditional quasi-Poisson regression model to examine the effects of haze vs. non-haze days in each subdivision, with lags of up to five  days, for different haze definitions and durations. RESULTS: The risk of respiratory visits was prominent during haze days but varied by haze characteristics. There was a 36.6% (95% confidence interval: 10.2%, 69.3%) and 74.4% (18.9%, 164.6%) increased risk of respiratory visits in Pulang Pisau Regency during haze and fire haze, respectively. The risk was pronounced when the haze was characterized by longer durations. CONCLUSION: Our findings suggest inconclusive effects of haze on respiratory visits to primary healthcare centers, although they appeared to be prominent in the area mainly dominated by fire haze. Haze characteristics should be analysed carefully for differences in risk patterns according to location.

Impact of prenatal drought exposures on under-5 childhood stunting in 32 low-and-middle-income countries: a global analysis using demographic and health survey.
Xerxes Seposo, Aden Kay Celis-Seposo, Athicha Uttajug, Muhammad Abdul Basit Ahmad Tajudin, Kayo Ueda
Environmental health : a global access science source, 24, 1, 61, 61, 2025年08月29日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Child stunting affects a substantial number of children globally, with an estimated 149 million worldwide. Environmental factors, including poor nutrition, household environment, inadequate sanitation, and meteorological variables have also significantly contributed to child stunting. Apart from temperature and rainfall, large-scale events such as drought have been found to influence the risk of stunting. While previous studies focused on post-natal drought, this research investigates the impact of pre-natal drought on childhood stunting in low- and middle-income countries. METHODS: We used nationally representative survey data of under 5 stunted children collected between 2013 and 2019 from Demographic and Health Survey (DHS) surveys for 32 low-income to middle-income countries in combination with high-resolution weather data from ERA5-Land climate re-analysis in generating the drought index (Standardized Precipitation-Evapotranspiration Index) that was then classified into various pre-natal and post-natal exposure periods. We used a generalized additive mixed-effect multivariable logistic regression modelling approach to assess the association between pre-natal drought and the risk of stunting. RESULTS: In examining the association between pre-natal drought exposure and under-5 child stunting, we analyzed a total of 284,702 children with geolocated, anthropometric data, composed of 147,448 (51%) girls and 137,254 (49%) boys. Pre-natal (or pre-natal) drought exposure on a long-term time scale increased the risk of under-5 stunting by 2.07% (95% CI: 0.48%, 3.63%). Pre-natal drought exposure particularly in the second and third trimesters were associated with 1.76% (95% CI: 0.22%, 3.27%) and 1.60% (95% CI: 0.15%, 3.02%) increase in the risk of under-5 childhood stunting, respectively. We found marginally significant association between the first trimester pre-natal drought exposure and the risk of stunting (1.53%; 95% CI: -0.13, 3.16%). CONCLUSION: Our large-scale population study of 32 LMICs has found that pre-natal drought exposure was significantly associated with under-5 child stunting, with pronounced risks during the second and third trimesters exposures. Drought plays a significant role in exacerbating child stunting, underscoring the necessity for effective drought management strategies and interventions to safeguard child nutrition and development.

All-Cause and Cause-Specific Mortality Associated with Long-Term Exposure to Fine Particulate Matter in Japan: The Ibaraki Prefectural Health Study.
Takehiro Michikawa, Yuji Nishiwaki, Keiko Asakura, Tomonori Okamura, Toru Takebayashi, Shuichi Hasegawa, Ai Milojevic, Mihoko Minami, Masataka Taguri, Ayano Takeuchi, Kayo Ueda, Toshimi Sairenchi, Kazumasa Yamagishi, Hiroyasu Iso, Fujiko Irie, Hiroshi Nitta
Journal of atherosclerosis and thrombosis, 32, 8, 982, 993, Japan Atherosclerosis Society, 2025年08月01日, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）, AIMS: Long-term exposure to fine particulate matter (PM2.5) is causally associated with mortality and cardiovascular disease. However, in terms of cardiovascular cause-specific outcomes, there are fewer studies about stroke than about coronary heart disease, particularly in Asia. Furthermore, there remains uncertainty regarding the PM2.5-respiratory disease association. We examined whether long-term exposure to PM2.5 is associated with all-cause, cardiovascular and respiratory disease mortality in Japan. METHODS: We used data of 46,974 participants (19,707 men; 27,267 women), who were enrolled in 2009 and followed up until 2019, in a community-based prospective cohort study (the second cohort of the Ibaraki Prefectural Health Study). We estimated PM2.5 concentrations using the inverse distance weighing methods based on ambient air monitoring data, and assigned each participant to administrative area level concentrations. A Cox proportional hazard model was applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of mortality. RESULTS: During the average follow-up of 10 years, we confirmed 2,789 all-cause deaths. All outcomes including stroke mortality did not significantly increase as the PM2.5 concentration increased. For non-malignant respiratory disease mortality, the multivariable adjusted HR per 1 µg/m3 increase in the PM2.5 concentration was 1.09 (95% CI = 0.97-1.23). CONCLUSIONS: In this population exposed to PM2.5 at concentrations of 8.3-13.1 µg/m3, there was no evidence that long-term exposure to PM2.5 had adverse effects on mortality. Weak evidence of positive association observed for non-malignant respiratory disease mortality needs further studies in other populations.

Air Temperature and Gastroenteritis Among Rohingya Populations in Bangladesh Refugee Camps.
Takuya Takata, Xerxes Seposo, Nasif Hossain, Kayo Ueda
JAMA network open, 8, 4, e255768, 2025年04月01日, ［査読有り］, ［最終著者］, ［国際誌］
英語, 研究論文（学術雑誌）, IMPORTANCE: The Rohingya displaced population in Bangladesh is the largest stateless population in the world. Infectious diseases, such as gastroenteritis, respiratory infections, and fever, are among the major health problems the Rohingya population has faced. Although associations between gastroenteritis and air temperature have been reported in various regions, no study has yet been carried out among the displaced populations. OBJECTIVES: To evaluate the association between air temperature and risk of gastroenteritis among the forcibly displaced Rohingya population in refugee camps in Bangladesh. DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study, daily time series data derived from facility-based case reports were collected in 2 clinics organized by the UNHCR (United Nations High Commissioner for Refugees) in Kutupalong and Nayapara registered camps from January 1, 2019, to December 31, 2021. Statistical analysis was conducted from April 2023 to September 2024. EXPOSURE: Hourly 2-m air temperature from ERA5-Land by the European Centre for Medium-Range Weather Forecasts. MAIN OUTCOMES AND MEASURES: The daily number of gastroenteritis cases recorded in the camp clinics was the main outcome measure. Nonlinear lagged associations between daily temperature and gastroenteritis cases were modeled using a quasi-Poisson generalized linear model to account for overdispersion coupled with a distributed lag nonlinear model including a maximum 21-day lag. Covariates from the literature were adjusted in the model. RESULTS: A total of 33 280 gastroenteritis cases (95% among individuals aged ≥5 years; 71% female) were recorded in Kutupalong and 31 165 gastroenteritis cases (99% among individuals aged ≥5 years; 67% female) were recorded in Nayapara. Further examination revealed a potential U-shaped curve in Kutupalong with minimum risk temperature (MRT) set at 26 °C. Cumulative relative risk (RR) at the 10th percentile temperature (21.1 °C) was 2.31 (95% CI, 1.18-4.65), while RR at 90th percentile temperature (28.5 °C) was 1.78 (95% CI, 1.24-2.56) relative to MRT. In Nayapara, a nearly linear risk increase was observed with decreasing temperature. Cumulative RR at the 10th percentile temperature (21 °C) was 1.32 (95% CI, 0.78-2.24), while the RR at the 90th percentile temperature (28.3 °C) was 0.75 (95% CI, 0.56-0.99). Lagged effects were delayed in nature. In Kutupalong, cold temperatures (10th percentile) were associated with statistically significant gastroenteritis risks at approximately 15 to 20 days (range: RR, 1.06 [95% CI, 1.00-1.13] to RR, 1.10 [95% CI, 1.00-1.21]). In Nayapara, gastroenteritis risks were correspondingly higher at longer lags (lag, 18 days; RR, 1.05 [95% CI, 1.00-1.10]). CONCLUSIONS AND RELEVANCE: In this cross-sectional study of the Rohingya displaced population in Bangladesh, cold temperatures were associated with an increase in the risk of gastroenteritis. It is important to understand the association of climatic factors with the health of displaced communities, whose population is expected to grow in the future.

The perception of air pollution and its health risk: a scoping review of measures and methods.
Zeinab Bahrami, Satomi Sato, Zhesi Yang, Monali Maiti, Paoin Kanawat, Tomohiro Umemura, Kazunari Onishi, Hiroaki Terasaki, Tomoki Nakayama, Yutaka Matsumi, Kayo Ueda
Global health action, 17, 1, 2370100, 2370100, Informa UK Limited, 2024年12月31日, ［査読有り］, ［責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Although there is increasing awareness of the health risks of air pollution as a global issue, few studies have focused on the methods for assessing individuals' perceptions of these risks. This scoping review aimed to identify previous research evaluating individuals' perceptions of air pollution and its health effects, and to explore the measurement of perceptions, as a key resource for health behaviour. METHODS: The review followed the methodological framework proposed by Arksey and O'Malley. PubMed and Web of Science were searched. After initial and full-text screening, we further selected studies with standardised scales that had previously been tested for reliability and validity in assessing awareness and perceptions. RESULTS: After full-text screening, 95 studies were identified. 'Perception/awareness of air quality' was often measured, as well as 'Perception of health risk.' Only nine studies (9.5%) used validated scaled questionnaires. There was considerable variation in the scales used to measure the multiple dimensions of risk perception for air pollution. CONCLUSION: Few studies used structured scales to quantify individuals' perceptions, limiting comparisons among studies. Standardised methods for measuring health risk perception are needed.

Non-optimal temperature-attributable mortality and morbidity burden by cause, age and sex under climate and population change scenarios: a nationwide modelling study in Japan.
Lei Yuan, Lina Madaniyazi, Ana M Vicedo-Cabrera, Chris Fook Sheng Ng, Kazutaka Oka, Paul L C Chua, Kayo Ueda, Aurelio Tobias, Yasushi Honda, Masahiro Hashizume
The Lancet regional health. Western Pacific, 52, 101214, 101214, Elsevier BV, 2024年11月, ［査読有り］, ［国際共著］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Future temperature effects on mortality and morbidity may differ. However, studies comparing projected future temperature-attributable mortality and morbidity in the same setting are limited. Moreover, these studies did not consider future population change, human adaptation, and the variations in subpopulation susceptibility. Thus, we simultaneously projected the temperature-related mortality and morbidity by cause, age, and sex under population change, and human adaptation scenarios in Japan, a super-ageing society. METHODS: We used daily mean temperatures, mortality, and emergency ambulance dispatch (a sensitive indicator for morbidity) in 47 prefectures of Japan from 2015 to 2019 as the reference for future projections. Future mortality and morbidity were generated at prefecture level using four shared socioeconomic pathway (SSP) scenarios considering population changes. We calculated future temperature-related mortality and morbidity by combining baseline values with future temperatures and existing temperature risk functions by cause (all-cause, circulatory, respiratory), age (<65 years, ≥65 years), and sex under various climate change and SSP scenarios (SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5). Full human adaptation was simulated based on empirical evidence using a fixed percentile of minimum mortality or morbidity temperature (MMT), while no adaptation was simulated with a fixed absolute MMT. FINDINGS: A future temporal decline in mortality burden attributable to non-optimal temperatures was observed, driven by greater cold-related deaths than heat-related deaths. In contrast, temperature-related morbidity increased over time, which was primarily driven by heat. In the 2050s and 2090s, under a moderate scenario, there are 83.69 (95% empirical confidence interval [eCI] 38.32-124.97) and 77.31 (95% eCI 36.84-114.47) all-cause deaths per 100,000 population, while there are 345.07 (95% eCI 258.31-438.66) and 379.62 (95% eCI 271.45-509.05) all-cause morbidity associated with non-optimal temperatures. These trends were largely consistent across causes, age, and sex groups. Future heat-attributable health burden is projected to increase substantially, with spatiotemporal variations and is particularly pronounced among individuals ≥65 y and males. Full human adaptation could yield a decreasing temperature-attributable mortality and morbidity in line with a decreasing population. INTERPRETATION: Our findings could support the development of targeted mitigation and adaptation strategies to address future heat-related impacts effectively. This includes improved healthcare allocations for ambulance dispatch and hospital preventive measures during heat periods, particularly custom-tailored to address specific health outcomes and vulnerable subpopulations. FUNDING: Japan Science and Technology Agency and Environmental Restoration and Conservation Agency and Ministry of the Environment of Japan.

Particulate Matter and Incident Chronic Kidney Disease in Japan: The Ibaraki Prefectural Health Study (IPHS).
Kei Nagai, Shin Araki, Toshimi Sairenchi, Kayo Ueda, Kazumasa Yamagishi, Masayuki Shima, Kouhei Yamamoto, Hiroyasu Iso, Fujiko Irie
JMA journal, 7, 3, 334, 341, 2024年07月16日, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）, INTRODUCTION: Global health hazards caused by air pollution, such as chronic kidney disease (CKD), have been gaining attention; however, air pollution-associated CKD has not been explored in Japan. METHODS: We examined 77,770 men and women with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 in the Ibaraki Prefecture who participated in annual community-based health checkups from 1993 at 40-75 years old and were followed up through December 2020. The outcome was newly developed kidney dysfunction with eGFR of <60 ml/min/1.73 m2 during follow-up. To assess air pollution, a PM2.5 exposure model was employed to estimate yearly means at 1 × 1-km resolution, converted into means at the municipal level. Hazard modeling was employed to examine PM2.5 concentrations in residential areas as a risk factor for outcomes. RESULTS: Participants were distributed across 23 municipalities in the Ibaraki Prefecture, with PM2.5 concentrations between 16.2 and 33.4 μg/m3 (mean, 22.7 μg/m3) in 1987-1995 as the exposure period. There were 942 newly developed kidney dysfunctions during follow-up. Based on 1987-1995 PM2.5 concentrations as the baseline exposure, the multivariate-adjusted hazard ratio per 10-μg/m3 increase in PM2.5 for newly developed kidney dysfunction was 1.02 (95%CI, 0.80-1.24) in men and 1.19 (95%CI, 0.95-1.44) in women. CONCLUSIONS: Elevated PM2.5 did not represent a significant risk factor for incident CKD in a prefecture in Japan.

Effects of Coexposure to Air Pollution from Vegetation Fires and Extreme Heat on Mortality in Upper Northern Thailand.
Athicha Uttajug, Xerxes Seposo, Arthit Phosri, Vera Ling Hui Phung, Muhammad Abdul Basit Ahmad Tajudin, Kayo Ueda
Environmental science & technology, 58, 23, 9945, 9953, American Chemical Society (ACS), 2024年06月11日, ［査読有り］, ［最終著者］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: understanding the effects of coexposure to compound extreme events, such as air pollution and extreme heat, is important for reducing current and future health burdens. This study investigated the independent and synergistic effects of exposure to air pollution from vegetation fires and extreme heat on all-cause mortality in Upper Northern Thailand. Methods: we used a time-stratified case-crossover study design with a conditional quasi-Poisson model to examine the association between mortality and coexposure to air pollution due to vegetation fire events (fire-PM2.5) and extreme heat. Extreme heat days were defined using the 90th and 99th percentile thresholds for daily maximum temperature. Results: we observed a significant positive excess risk of mortality due to independent exposure to fire-PM2.5 and extreme heat, but not an interactive effect. All-cause mortality risk increased by 0.9% (95% confidence interval (CI): 0.1, 1.8) for each 10 μg/m3 increase in fire-PM2.5 on the same day and by 12.8% (95% CI: 10.5, 15.1) on extreme heat days (90th percentile) relative to nonextreme heat days. Conclusion: this study showed that exposure to PM2.5 from vegetation fires and extreme heat independently increased all-cause mortality risk in UNT. However, there was no evidence of a synergistic effect of these events.

福岡における越境/局地大気汚染・健康影響に関する研究
髙島久洋, 原圭一郎, 西田千春, 白石浩一, 林政彦, 伊禮聡, 兼保直樹, 高良太, 小林拓, 丸本幸治, 奥田知明, 長田和雄, 乙部直人, 高見昭憲, 内尾英一, 上田佳代, 山崎明宏, 吉野彩子
エアロゾル研究, 39, 2, 129, 144, 2024年06月, ［査読有り］
日本語, 研究論文（学術雑誌）

Interplay of Climate Change and Air Pollution- Projection of the under-5 mortality attributable to ambient particulate matter (PM2.5) in South Asia.
Wahida Musarrat Anita, Athicha Uttajug, Xerxes Tesoro Seposo, Kengo Sudo, Makiko Nakata, Toshihiko Takemura, Hirohisa Takano, Taku Fujiwara, Kayo Ueda
Environmental research, 248, 118292, 118292, 2024年05月01日, ［査読有り］, ［最終著者］, ［国際誌］
英語, 研究論文（学術雑誌）, Ambient fine particulate matter (PM2.5) pollution is a leading health risk factor for children under- 5 years, especially in developing countries. South Asia is a PM2.5 hotspot, where climate change, a potential factor affecting PM2.5 pollution, adds a major challenge. However, limited evidence is available on under-5 mortality attributable to PM2.5 under different climate change scenarios. This study aimed to project under-5 mortality attributable to long-term exposure to ambient PM2.5 under seven air pollution and climate change mitigation scenarios in South Asia. We used a concentration-risk function obtained from a previous review to project under-5 mortality attributable to ambient PM2.5. With a theoretical minimum risk exposure level of 2.4 μg/m3, this risk function was linked to gridded annual PM2.5 concentrations from atmospheric modeling to project under-5 mortality from 2010 to 2049 under different climate change mitigation scenarios. The scenarios were developed from the Aim/Endues global model based on end-of-pipe (removing the emission of air pollutants at the source, EoP) and 2 °C target measures. Our results showed that, in 2010-2014, about 306.8 thousand under-5 deaths attributable to PM2.5 occurred in South Asia under the Reference (business as usual) scenario. The number of deaths was projected to increase in 2045-2049 by 36.6% under the same scenario and 7.7% under the scenario where EoP measures would be partially implemented by developing countries (EoPmid), and was projected to decrease under other scenarios, with the most significant decrease (81.2%) under the scenario where EoP measures would be fully enhanced by all countries along with the measures to achieve 2 °C target (EoPmaxCCSBLD) across South Asia. Country-specific projections of under-5 mortality varied by country. The current emission control strategy would not be sufficient to reduce the number of deaths in South Asia. Robust climate change mitigation and air pollution control policy implementation is required.

The effect modification of PM2.5 and ozone on the short-term associations between temperature and mortality across the urban areas of Japan.
Muhammad Abdul Basit Ahmad Tajudin, Ryusei Kubo, Chris Fook Sheng Ng, Masahiro Hashizume, Xerxes Seposo, Yoonhee Kim, Hironori Nishikawa, Hirohisa Takano, Kayo Ueda
Environmental health and preventive medicine, 29, 57, 57, 2024年, ［査読有り］, ［最終著者］, ［国内誌］
英語, 研究論文（学術雑誌）, BACKGROUND: The acute effects of temperature and air pollution on mortality are well-known environmental factors that have been receiving more recognition lately. However, the health effects resulting from the interaction of air pollution and temperature remain uncertain, particularly in cities with low levels of pollution. This study aims to examine the modification effects of particulate matter with a diameter of 2.5 µm or less (PM2.5) and ozone (O3) on the association between temperature and mortality. METHODS: We collected the daily number of all-cause, cardiovascular, and respiratory mortality from 20 major cities in Japan from 2012-2018. We obtained meteorological data from the Japan Meteorological Agency and air pollution data from the National Institute for Environmental Studies. We conducted analyses using a quasi-Poisson regression model with a distributed lag non-linear model for temperature in each city and subsequently performed a random-effects meta-analysis to derive average estimates. RESULTS: We found that high levels of O3 might positively modify the mortality risk of heat exposure, especially for cardiovascular diseases. Subgroups such as the elderly and females were susceptible. We did not observe consistent evidence of effect modification by PM2.5, including effect modification on cold by both pollutants. CONCLUSION: PM2.5 and O3 may positively modify the short-term association between heat and mortality in the urban areas of Japan. These results highlight the need for public health policies and interventions to address the collective impacts of both temperature and air pollution.

Associations between residential greenness and air pollution and the incident metabolic syndrome in a Thai worker cohort.
Kanawat Paoin, Chanathip Pharino, Prin Vathesatogkit, Arthit Phosri, Suhaimee Buya, Kayo Ueda, Xerxes Tesoro Seposo, Thammasin Ingviya, Krittika Saranburut, Nisakron Thongmung, Teerapat Yingchoncharoen, Piyamitr Sritara
International journal of biometeorology, 67, 12, 1965, 1974, 2023年12月, ［査読有り］, ［国際共著］, ［国際誌］
英語, 研究論文（学術雑誌）, Increasing air pollution and decreasing exposure to greenness may contribute to the metabolic syndrome (MetS). We examined associations between long-term exposure to residential greenness and air pollution and MetS incidence in the Bangkok Metropolitan Region, Thailand. Data from 1369 employees (aged 52-71 years) from the Electricity Generating Authority of Thailand cohort from 2002 to 2017 were analyzed. The greenness level within 500 m of each participant's residence was measured using the satellite-derived Normalized Difference Vegetation Index (NDVI) and Enhanced Vegetation Index (EVI). The kriging approach was used to generate the average concentration of each air pollutant (PM10, CO, SO2, NO2, and O3) at the sub-district level. The average long-term exposure to air pollution and greenness for each participant was calculated over the same period of person-time. Cox proportional hazards models were used to analyze the greenness-air pollution-MetS associations. The adjusted hazard ratio of MetS was 1.42 (95% confidence interval (CI): 1.32, 1.53), 1.22 (95% CI: 1.15, 1.30), and 2.0 (95% CI: 1.82, 2.20), per interquartile range increase in PM10 (9.5 μg/m3), SO2 (0.9 ppb), and CO (0.3 ppm), respectively. We found no clear association between NDVI or EVI and the incidence of MetS. On the contrary, the incident MetS was positively associated with NDVI and EVI for participants exposed to PM10 at concentrations more than 50 μg/m3. In summary, the incidence of MetS was positively associated with long-term exposure to air pollution. In areas with high levels of air pollution, green spaces may not benefit health outcomes.

A Nationwide Comparative Analysis of Temperature-Related Mortality and Morbidity in Japan.
Lei Yuan, Lina Madaniyazi, Ana M Vicedo-Cabrera, Yasushi Honda, Chris Fook Sheng Ng, Kayo Ueda, Kazutaka Oka, Aurelio Tobias, Masahiro Hashizume
Environmental health perspectives, 131, 12, 127008, 127008, 2023年12月, ［査読有り］, ［国際共著］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: The impact of temperature on morbidity remains largely unknown. Moreover, extensive evidence indicates contrasting patterns between temperature-mortality and temperature-morbidity associations. A nationwide comparison of the impact of temperature on mortality and morbidity in more specific subgroups is necessary to strengthen understanding and help explore underlying mechanisms by identifying susceptible populations. OBJECTIVE: We performed this study to quantify and compare the impact of temperature on mortality and morbidity in 47 prefectures in Japan. METHODS: We applied a two-stage time-series design with distributed lag nonlinear models and mixed-effect multivariate meta-analysis to assess the association of temperature with mortality and morbidity by causes (all-cause, circulatory, and respiratory) at prefecture and country levels between 2015 and 2019. Subgroup analysis was conducted by sex, age, and regions. RESULTS: The patterns and magnitudes of temperature impacts on morbidity and mortality differed. For all-cause outcomes, cold exhibited larger effects on mortality, and heat showed larger effects on morbidity. At specific temperature percentiles, cold (first percentile) was associated with a higher relative risk (RR) of mortality [1.45; 95% confidence interval (CI): 1.39, 1.52] than morbidity (1.33; 95% CI: 1.26, 1.40), as compared to the minimum mortality/morbidity temperature. Heat (99th percentile) was associated with a higher risk of morbidity (1.30; 95% CI: 1.28, 1.33) than mortality (1.04; 95% CI: 1.02, 1.06). For cause-specific diseases, mortality due to circulatory diseases was more susceptible to heat and cold than morbidity. However, for respiratory diseases, both cold and heat showed higher risks for morbidity than mortality. Subgroup analyses suggested varied associations depending on specific outcomes. DISCUSSION: Distinct patterns were observed for the association of temperature with mortality and morbidity, underlying different mechanisms of temperature on different end points, and the differences in population susceptibility are possible explanations. Future mitigation policies and preventive measures against nonoptimal temperatures should be specific to disease outcomes and targeted at susceptible populations. https://doi.org/10.1289/EHP12854.

Enhancing health resilience in Japan in a changing climate.
Yoonhee Kim, Kazutaka Oka, Erin C Kawazu, Chris Fook Sheng Ng, Xerxes Seposo, Kayo Ueda, Masahiro Hashizume, Yasushi Honda
The Lancet regional health. Western Pacific, 40, 100970, 100970, 2023年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Climate change poses significant threats to human health, propelling Japan to take decisive action through the Climate Change Adaptation Act of 2018. This Act has led to the implementation of climate change adaptation policies across various sectors, including healthcare. In this review, we synthesized existing scientific evidence on the impacts of climate change on health in Japan and outlined the adaptation strategies and measures implemented by the central and local governments. The country has prioritized tackling heat-related illness and mortality and undertaken various adaptation measures to mitigate these risks. However, it faces unique challenges due to its super-aged society. Ensuring effective and coordinated strategies to address the growing uncertainties in vulnerability to climate change and the complex intersectoral impacts of disasters remains a critical issue. To combat the additional health risks by climate change, a comprehensive approach embracing adaptation and mitigation policies in the health sector is crucial. Encouraging intersectoral communication and collaboration will be vital for developing coherent and effective strategies to safeguard public health in the face of climate change.

Economic burden of cancer attributable to modifiable risk factors in Japan.
Eiko Saito, Shiori Tanaka, Sarah Krull Abe, Mayo Hirayabashi, Junko Ishihara, Kota Katanoda, Yingsong Lin, Chisato Nagata, Norie Sawada, Ribeka Takachi, Atsushi Goto, Junko Tanaka, Kayo Ueda, Megumi Hori, Tomohiro Matsuda, Manami Inoue
Global health & medicine, 5, 4, 238, 245, 2023年08月31日, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）, Controlling avoidable causes of cancer may save cancer-related healthcare costs and indirect costs of premature deaths and productivity loss. This study aimed to estimate the economic burden of cancer attributable to major lifestyle and environmental risk factors in Japan in 2015. We evaluated the economic cost of cancer attributable to modifiable risk factors from a societal perspective. We obtained the direct medical costs for 2015 from the National Database of Health Insurance Claims and Specific Health Checkups of Japan, and estimated the indirect costs of premature mortality and of morbidity due to cancer using the relevant national surveys in Japan. Finally, we estimated the economic cost of cancer associated with lifestyle and environmental risk factors. The estimated cost of cancer attributable to lifestyle and environmental factors was 1,024,006 million Japanese yen (\) (8,460 million US dollars [$]) for both sexes, and \673,780 million ($5,566 million) in men and \350,226 million ($2,893 million) in women, using the average exchange rate in 2015 ($1 = \121.044). A total of \285,150 million ($2,356 million) was lost due to premature death in Japan in 2015. Indirect morbidity costs that could have been prevented were estimated to be \200,602 million ($1,657 million). Productivity loss was highest for stomach cancer in men (\28,735 million/$237 million) and cervical cancer in women (\24,448 million/$202 million). Preventing and controlling cancers caused by infections including Helicobacter pylori, human papillomavirus and tobacco smoking will not only be life-saving but may also be cost-saving in the long run.

Differential Pattern of Cell Death and ROS Production in Human Airway Epithelial Cells Exposed to Quinones Combined with Heated-PM2.5 and/or Asian Sand Dust
A Honda, KI Inoue, M Higashihara, T Ichinose, K Ueda, H Takano
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24, 13, 10544, 2023年07月, ［査読有り］
英語, 研究論文（学術雑誌）

Association between extreme rainfall and acute respiratory infection among children under-5 years in sub-Saharan Africa: an analysis of Demographic and Health Survey data, 2006-2020.
Athicha Uttajug, Kayo Ueda, Xerxes Seposo, Joel Msafiri Francis
BMJ open, 13, 4, e071874, 2023年04月25日, ［査読有り］, ［国際共著］, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVE: Despite an increase in the number of studies examining the association between extreme weather events and infectious diseases, evidence on respiratory infection remains scarce. This study examined the association between extreme rainfall and acute respiratory infection (ARI) in children aged <5 years in sub-Saharan Africa. SETTING: Study data were taken from recent (2006-2020) Demographic and Health Survey data sets from 33 countries in sub-Saharan Africa. PARTICIPANTS: 280 157 children aged below 5 years were included. OUTCOME MEASURES: The proportions of ARI according to individual, household and geographical characteristics were compared using the χ2 test. The association between extreme rainfall (≥90th percentile) and ARI was examined using multivariate logistic regression for 10 of 33 countries with an adequate sample size of ARI and extreme rainfall events. The model was adjusted for temperature, comorbidity and sociodemographic factors as covariates. Stratification analyses by climate zone were also performed. RESULTS: The prevalence of ARI in children aged <5 years ranged from 1.0% to 9.1% across sub-Saharan Africa. By country, no significant association was observed between extreme rainfall and ARI, except in Nigeria (OR: 2.14, 95% CI 1.06 to 4.31). Larger effect estimates were observed in the tropical zone (OR: 1.13, 95% CI 0.69 to 1.84) than in the arid zone (OR: 0.72, 95% CI 0.17 to 2.95), although the difference was not statistically significant. CONCLUSION: We found no association between extreme rainfall and ARI in sub-Saharan Africa. Effect estimates tended to be larger in the tropical zone where intense rainfall events regularly occur. Comprehensive studies to investigate subsequent extreme climate events, such as flooding, are warranted in the future.

Long-term associations of air pollution exposure with liver enzymes among adult employees of the Electricity Generating Authority of Thailand: A longitudinal cohort study
Kanawat Paoin, Chanathip Pharino, Prin Vathesatogkit, Suhaimee Buya, Krittika Saranburut, Arthit Phosri, Kayo Ueda, Xerxes Tesoro Seposo, Thammasin Ingviya, Taya Kitiyakara, Nisakron Thongmung, Piyamitr Sritara
Atmospheric Environment, 2023年04月
研究論文（学術雑誌）

Child Abuse Consultation Rates Before vs During the COVID-19 Pandemic in Japan.
Xerxes Seposo, Aden Kay Celis-Seposo, Kayo Ueda
JAMA network open, 6, 3, e231878, 2023年03月01日, ［査読有り］, ［最終著者］, ［国際誌］
英語, 研究論文（学術雑誌）

Association between greenness and cardiovascular risk factors: Results from a large cohort study in Thailand.
Kanawat Paoin, Chanathip Pharino, Arthit Phosri, Kayo Ueda, Xerxes Tesoro Seposo, Matthew Kelly, Sam-Ang Seubsman, Adrian Sleigh
Environmental research, 220, 115215, 115215, 2023年03月01日, ［査読有り］, ［国際共著］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: The risk of cardiovascular diseases may be reduced by residing in green environments. However, there are relatively few longitudinal cohort studies, especially in Southeast Asia, that focused on the health benefits of long-term greenness exposure in young adults. The present study examined the association between long-term exposure to residential greenness and self-reported morbidities in participants of the Thai Cohort Study (TCS) in Thailand from 2005 to 2013. METHODS: The self-reported outcomes, including high blood pressure, high blood cholesterol, and diabetes, were reported in 2005, 2009, and 2013, where the study participants provided the exact year of disease occurrence. Greenness was assessed by the satellite-based Normalized Difference Vegetation Index (NDVI) and Enhanced Vegetation Index (EVI), with a spatial resolution of 250 m. Long-term exposure to NDVI and EVI of each participant's sub-district was averaged over the period of person-time. We used Cox proportional hazards models to examine the association between greenness and health outcomes. Associations with self-reported morbidity were measured using hazard ratios (HRs) per interquartile range (IQR) increase in NDVI and EVI. RESULTS: After adjusting for potential confounders, we observed that an IQR increase in NDVI was associated with lower incidence of high blood pressure (HR = 0.92, 95% CI: 0.89, 0.97) and high blood cholesterol (HR = 0.89, 95%CI: 0.87, 0.92), but not significantly associated with diabetes (HR = 0.93, 95%CI: 0.85, 1.01). EVI was also inversely associated with self-reported high blood pressure (HR = 0.92, 95%CI: 0.88, 0.96), high blood cholesterol (HR = 0.89, 95%CI: 0.87, 0.91), and diabetes (HR = 0.92, 95%CI: 0.85, 0.99). CONCLUSIONS: Long-term exposure to residential greenness was inversely associated with self-reported high blood pressure, high blood cholesterol, and diabetes in participants of TCS. Our study provides evidence that greenness exposure may reduce cardiovascular disease risk factors in adult population.

Effect modification by temperature on the association between O3 and emergency ambulance dispatches in Japan: A multi-city study.
Arthit Phosri, Kayo Ueda, Xerxes Seposo, Akiko Honda, Hirohisa Takano
The Science of the total environment, 861, 160725, 160725, 2023年02月25日, ［査読有り］, ［国際共著］, ［国際誌］
英語, 研究論文（学術雑誌）, Numerous epidemiological studies have reported that ozone (O3) and temperature are independently associated with health outcomes, but modification of the effects of O3 on health outcomes by temperature, and vice versa, has not been fully described. This study aimed to investigate effect modification by temperature on the association between O3 and emergency ambulance dispatches (EADs) in Japan. Data on daily air pollutants, ambient temperature, and EADs were obtained from eight Japanese cities from 2007 to 2015. A distributed lag non-linear model combined with Poisson regression was performed with temperature as a confounding factor and effect modifier to estimate the effects of O3 on EADs at low (<25th percentile), moderate (25th-75th percentile), and high (>75th percentile) temperature for each city. The estimates obtained from each city were pooled by random-effects meta-analysis. When temperature was entered as a confounder, the estimated effects of O3 on EADs for all acute, cardiovascular, and respiratory illnesses were largest at lag 0 (current-day lag). Therefore, this lag was used to further estimate the effects of O3 on EADs in each temperature category. The estimated effects of O3 on EADs for all acute, cardiovascular, and respiratory illnesses in all eight Japanese cities increased with increasing temperature. Specifically, a 10 ppb increase in O3 was associated with 0.80 % (95 % CI: 0.25 to 1.35), 0.19 % (95 % CI: -0.85 to 1.25), and 1.14 % (95 % CI: -0.01 to 2.31) increases in the risk of EADs for all acute, cardiovascular, and respiratory illnesses, respectively, when city-specific daily temperature exceeded the 75th percentile. Our findings suggest that the association between O3 and EADs for all acute, cardiovascular, and respiratory illnesses is the highest during high temperature. Finding of this study can be used to develop potential mitigation measures against O3 exposure in high temperature environment to reduce its associated adverse health effects.

Association between Long-Term Ambient PM2.5 Exposure and under-5 Mortality: A Scoping Review.
Wahida Musarrat Anita, Kayo Ueda, Athicha Uttajug, Xerxes Tesoro Seposo, Hirohisa Takano
International journal of environmental research and public health, 20, 4, 2023年02月13日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Studies have established a link between exposure to fine particles (PM2.5) and mortality in infants and children. However, few studies have explored the association between post-birth exposure to PM2.5 and under-5 mortality. We conducted a scoping review to identify relevant epidemiological evidence on the association between post-birth ambient PM2.5 exposure and under-5 mortality. We searched PubMed and Web of Science for articles published between 1970 and the end of January 2022 that explicitly linked ambient PM2.5 and under-5 mortality by considering the study area, study design, exposure window, and child age. Information was extracted on the study characteristics, exposure assessment and duration, outcomes, and effect estimates/findings. Ultimately, 13 studies on infant and child mortality were selected. Only four studies measured the effect of post-birth exposure to PM2.5 on under-5 mortality. Only one cohort study mentioned a positive association between post-birth ambient PM2.5 exposure and under-5 mortality. The results of this scoping review highlight the need for extensive research in this field, given that long-term exposure to ambient PM2.5 is a major global health risk and child mortality remains high in some countries.

Daily temperature effects on under-five mortality in a tropical climate country and the role of local characteristics.
Vera Ling Hui Phung, Kazutaka Oka, Yasushi Honda, Yasuaki Hijioka, Kayo Ueda, Xerxes Tesoro Seposo, Mazrura Sahani, Wan Rozita Wan Mahiyuddin, Yoonhee Kim
Environmental research, 218, 114988, 114988, 2023年02月01日, ［査読有り］, ［国際共著］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Climate change and its subsequent effects on temperature have raised global public health concerns. Although numerous epidemiological studies have shown the adverse health effects of temperature, the association remains unclear for children aged below five years old and those in tropical climate regions. METHODS: We conducted a two-stage time-stratified case-crossover study to examine the association between temperature and under-five mortality, spanning the period from 2014 to 2018 across all six regions in Malaysia. In the first stage, we estimated region-specific temperature-mortality associations using a conditional Poisson regression and distributed lag nonlinear models. We used a multivariate meta-regression model to pool the region-specific estimates and examine the potential role of local characteristics in the association, which includes geographical information, demographics, socioeconomic status, long-term temperature metrics, and healthcare access by region. RESULTS: Temperature in Malaysia ranged from 22 °C to 31 °C, with a mean of 27.6 °C. No clear seasonality was observed in under-five mortality. We found no strong evidence of the association between temperature and under-five mortality, with an "M-" shaped exposure-response curve. The minimum mortality temperature (MMT) was identified at 27.1 °C. Among several local characteristics, only education level and hospital bed rates reduced the residual heterogeneity in the association. However, effect modification by these variables were not significant. CONCLUSION: This study suggests a null association between temperature and under-five mortality in Malaysia, which has a tropical climate. The "M-" shaped pattern suggests that under-fives may be vulnerable to temperature changes, even with a small temperature change in reference to the MMT. However, the weak risks with a large uncertainty at extreme temperatures remained inconclusive. Potential roles of education level and hospital bed rate were statistically inconclusive.

Long-term trends in mortality risk associated with short-term exposure to air pollution in 10 Japanese cities between 1977 and 2015.
Hironori Nishikawa, Xerxes Tesoro Seposo, Lina Madaniyazi, Yoonhee Kim, Aurelio Tobías, Makiko Yamagami, Satbyul Estella Kim, Akinori Takami, Seiji Sugata, Yasushi Honda, Kayo Ueda, Masahiro Hashizume, Chris Fook Sheng Ng
Environmental research, 219, 115108, 115108, 2022年12月19日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND AND AIM: Short-term associations between air pollution and mortality have been well reported in Japan, but the historical changes in mortality risk remain unknown. We examined temporal changes in the mortality risks associated with short-term exposure to four criteria air pollutants in selected Japanese cities. METHODS: We collected daily mortality data for non-accidental causes (n = 5,748,206), cardiovascular (n = 1,938,743) and respiratory diseases (n = 777,266), and air pollutants (sulfur dioxide [SO2], nitrogen dioxide [NO2], suspended particulate matter [SPM], and oxidants [Ox]) in 10 cities from 1977 to 2015. We performed two-stage analysis with 5-year stratification to estimate the relative risk (RR) of mortality per 10-unit increase in the 2-day moving average of air pollutant concentrations. In the first stage, city-specific associations were assessed using a quasi-Poisson generalized linear regression model. In the second stage, city-specific estimates were pooled using a random-effects meta-analysis. Linear trend and ratio of relative risks (RRR) were computed to examine temporal changes. RESULTS: When stratifying the analysis by every 5 years, average concentrations in each sub-period decreased for SO2, NO2, and SPM (14.2-2.3 ppb, 29.4-17.5 ppb, 52.1-20.6 μg/m3, respectively) but increased for Ox (29.1-39.1 ppb) over the study period. We found evidence of a negative linear trend in the risk of cardiovascular mortality associated with SPM across sub-periods. However, the risks of non-accidental and respiratory mortality per 10-unit increase in SPM concentration were significantly higher in the most recent period than in the earliest period. Other gaseous pollutants did not show such temporal risk change. The risks posed by these pollutants were slightly to moderately heterogeneous in the different cities. CONCLUSIONS: The mortality risks associated with short-term exposure to SPM changed, with different trends by cause of death, in 10 cities over 39 years whereas the risks for other gaseous pollutants were relatively stable.

Effects of Streamer Discharge on PM2.5 Containing Endotoxins and Polyaromatic Hydrocarbons and Their Biological Responses In Vitro.
Akiko Honda, Ken-Ichiro Inoue, Shin Tamura, Michitaka Tanaka, Zaoshi Wang, Toshio Tanaka, Seitarou Hirai, Tomoaki Okuda, Kayo Ueda, Hirohisa Takano
International journal of molecular sciences, 23, 24, 2022年12月14日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Experimental and epidemiological studies have demonstrated that fine particulate matter with a diameter of <2.5 μm (PM2.5) affects both the respiratory and immune systems. However, effective approaches to reduce PM2.5-induced hazardous effects have not been discovered yet. Streamer discharge is a category of plasma discharge in which high-speed electrons collide with oxygen and nitrogen molecules. Although streamer discharge can reportedly eliminate bacteria, molds, chemical substances, and allergens, its ability to decontaminate PM2.5 has not been previously demonstrated. The present study explored whether streamer discharge treatment could reduce PM2.5-induced inflammatory responses by employing an in vitro system. PM2.5 was collected under four conditions (Bangkok (Sep.−Dec.), Bangkok (Dec.−Mar.), Singapore, and Taipei). Airway epithelial cells and antigen-presenting cells exposed to non-treated PM2.5 in several conditions resulted in inflammatory responses. Streamer-discharged PM2.5 (Bangkok (Sep.−Dec.)) decreased the expression of interleukin (IL)-6 and IL-8 compared to non-treated PM2.5. Moreover, composition analysis demonstrated that streamer discharge reduced some compounds, such as endotoxins and polycyclic aromatic hydrocarbons, included in PM2.5 that can elicit inflammatory responses. Streamer discharge treatment can reduce endotoxins, polycyclic aromatic hydrocarbons, and the subsequent inflammatory responses induced by PM2.5 in vitro.

オゾン-心肺外来の関連における窒素酸化物の役割
SEPOSO Xerxes, 上田佳代, NG Chris Fook Sheng, NG Chris Fook Sheng, MADANIYAZI Lina, 菅田誠治, 吉野彩子, 高見昭憲
日本衛生学雑誌(Web), 317, Supplement, 120802, 120802, 2022年12月, ［査読有り］, ［国際誌］
英語, Ozone (O3)-induced health effects vary in terms of severity, from deterioration of lung function and hospitalization to death. Several studies have reported a linear increase in health risks after O3 exposure. However, current evidence suggests a non-linear U- and J-shaped concentration-response (C-R) function. The potential increasing risks with decreasing O3 concentrations may seem counterintuitive from the traditional standpoint that decreasing exposure should lead to decreasing health risks. Tus, the question of whether the increasing risks with decreasing concentrations are truly O3-induced or might be from other C-R mechanisms. If these potential risks were not accounted for, this may have contributed to the risks observed at the low ozone concentration range. In this study, we examined the short-term effects of photochemical oxidant (Ox, parts per billiion) on outpatient cardiorespiratory visits in 21 Japanese cities after adjusting for other air pollutant-specific C-R functions. Daily cardiorespiratory visits from January 1, 2014 to December 31, 2016 were obtained from the Japanese Medical Data Center Co. Ltd. Similar period of meteorological and air pollution variables were obtained from relevant data sources. We utilized a time-stratified case crossover design coupled with the generalized additive mixed model (TSCC-GAMM) to estimate the association between Ox and cardiorespiratory outpatient visits, after adjusting for several covariates. A total of 2,588,930 visits were recorded across the study period, with a mean of 111.87 and a standard deviation of 138.75. The results revealed that crude Ox-cardiorespiratory visits exhibited a U-shaped pattern. However, adjustment of the oxides of nitrogen, particularly nitrogen monoxide (NO), attenuated the lower risk curve and subsequently altered the shape of the C-R function, with a substantial reduction observed during winter. NO- and nitrogen dioxide (NO2)-adjusted Ox-cardiorespiratory associations increased nearly linearly, without an apparent threshold. Current evidence suggests the importance of adjusting the oxides of nitrogen in estimating the Ox C-R risk functions.

Estimation of hospital visits for respiratory diseases attributable to PM10 from vegetation fire smoke and health impacts of regulatory intervention in Upper Northern Thailand
Athicha Uttajug, Kayo Ueda, Akiko Honda, Hirohisa Takano
Scientific Reports, 12, 1, Springer Science and Business Media LLC, 2022年11月02日, ［査読有り］
研究論文（学術雑誌）, Abstract

The air quality in Upper Northern Thailand (UNT) deteriorates during seasonal vegetation fire events, causing adverse effects especially on respiratory health outcomes. This study aimed to quantitatively estimate respiratory morbidity from vegetation fire smoke exposure, and to assess the impact of a burning ban enforced in 2016 on morbidity burden in UNT. We computed daily population exposure to fire-originated PM₁₀ and estimated its health burden during a 5-year period from 2014 to 2018 using daily fire-originated PM₁₀ concentration and the concentration–response function for short-term exposure to PM₁₀ from vegetation fire smoke and respiratory morbidity. In subgroups classified as children and older adults, the health burden of respiratory morbidity was estimated using specific effect coefficients from previous studies conducted in UNT. Finally, we compared the health burden of respiratory morbidity before and after burning ban enforcement. Approximately 130,000 hospital visits for respiratory diseases were estimated to be attributable to fire-originated PM₁₀ in UNT from 2014 to 2018. This estimation accounted for 1.3% of total hospital visits for respiratory diseases during the 5-year period, and 20% of those during burning events. Age-specific estimates revealed a larger impact of PM₁₀ in the older adult group. The number of hospital visits for respiratory diseases attributable to fire-originated PM₁₀ decreased from 1.8% to 0.5% after the burning ban policy was implemented in the area. Our findings suggest that PM₁₀ released from vegetation fires is a health burden in UNT. The prohibition of the burning using regulatory measure had a positive impact on respiratory morbidity in this area.

Environmental variable importance for under-five mortality in Malaysia: A random forest approach
Vera Ling Hui Phung, Kazutaka Oka, Yasuaki Hijioka, Kayo Ueda, Mazrura Sahani, Wan Rozita Wan Mahiyuddin
Science of The Total Environment, 845, 157312, 157312, Elsevier BV, 2022年11月, ［査読有り］, ［国際共著］, ［国際誌］
研究論文（学術雑誌）

Effects of Oxidized Pyrenes on the Biological Responses in the Human Bronchial Epithelial Cells
Akiko Honda, Ken-ichiro Inoue, Satsuki Takai, Takayuki Kameda, Kayo Ueda, Hirohisa Takano
APPLIED SCIENCES-BASEL, 12, 19, 2022年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

A scoping review on the health effects of smoke haze from vegetation and peatland fires in Southeast Asia: Issues with study approaches and interpretation
Vera Ling Hui Phung, Attica Uttajug, Kayo Ueda, Nina Yulianti, Mohd Talib Latif, Daisuke Naito
PLOS ONE, 17, 9, e0274433, e0274433, Public Library of Science (PLoS), 2022年09月15日, ［査読有り］, ［国際共著］, ［国際誌］
研究論文（学術雑誌）, Smoke haze due to vegetation and peatland fires in Southeast Asia is a serious public health concern. Several approaches have been applied in previous studies; however, the concepts and interpretations of these approaches are poorly understood. In this scoping review, we addressed issues related to the application of epidemiology (EPI), health burden estimation (HBE), and health risk assessment (HRA) approaches, and discussed the interpretation of findings, and current research gaps. Most studies reported an air quality index exceeding the ‘unhealthy’ level, especially during smoke haze periods. Although smoke haze is a regional issue in Southeast Asia, studies on its related health effects have only been reported from several countries in the region. Each approach revealed increased health effects in a distinct manner: EPI studies reported excess mortality and morbidity during smoke haze compared to non-smoke haze periods; HBE studies estimated approximately 100,000 deaths attributable to smoke haze in the entire Southeast Asia considering all-cause mortality and all age groups, which ranged from 1,064–260,000 for specified mortality cause, age group, study area, and study period; HRA studies quantified potential lifetime cancer and non-cancer risks due to exposure to smoke-related chemicals. Currently, there is a lack of interconnection between these three approaches. The EPI approach requires extensive effort to investigate lifetime health effects, whereas the HRA approach needs to clarify the assumptions in exposure assessments to estimate lifetime health risks. The HBE approach allows the presentation of health impact in different scenarios, however, the risk functions used are derived from EPI studies from other regions. Two recent studies applied a combination of the EPI and HBE approaches to address uncertainty issues due to the selection of risk functions. In conclusion, all approaches revealed potential health risks due to smoke haze. Nonetheless, future studies should consider comparable exposure assessments to allow the integration of the three approaches.

A Case-Crossover Analysis of the Association between Exposure to Total PM2.5 and Its Chemical Components and Emergency Ambulance Dispatches in Tokyo.
Takehiro Michikawa, Junichi Sasaki, Shin Yamazaki, Akinori Takami, Keiko Asakura, Haruhiko Imamura, Kayo Ueda, Shinji Saito, Junya Hoshi, Ayako Yoshino, Seiji Sugata, Hiroshi Nitta, Yuji Nishiwaki
Environmental science & technology, 56, 11, 7319, 7327, 2022年06月07日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, A limited number of studies have investigated the association between short-term exposure to PM2.5 components and morbidity. The present case-crossover study explored the association between exposure to total PM2.5 and its components and emergency ambulance dispatches, which is one of the indicators of morbidity, in the 23 Tokyo wards. Between 2016 and 2018 (mean mass concentrations of total PM2.5 13.5 μg/m3), we obtained data, from the Tokyo Fire Department, on the daily cases of ambulance dispatches. Fine particles were collected at a fixed monitoring site and were analyzed to estimate the daily mean concentrations of carbons and ions. We analyzed 1038301 cases of health-based all-cause ambulance dispatches by using a conditional logistic regression model. The average concentrations of total PM2.5 over one and the previous day were positively associated with the number of ambulance dispatches. In terms of PM2.5 components, the percentage increase per interquartile range (IQR) increase was 0.8% for elemental carbon (IQR = 0.8 μg/m3; 95% CI = 0.3-1.3%), 0.9% for sulfate (2.1 μg/m3; 0.5-1.4%), and 1.1% for ammonium (1.3 μg/m3; 0.4-1.8%) in the PM2.5-adjusted models. This is the first study to find an association between some specific components in PM2.5 and ambulance dispatches.

アレルギーを悪化させるパーソナルケア製品の同定
本田 晶子, 丹 嵯織, 宮坂 奈津子, 雑賀 大輔, 邱 彬洋, 長尾 慧, 李 銀鵬, 王 造時, 石川 良賀, 上田 佳代, 高野 裕久
The Journal of Toxicological Sciences, 47, Suppl., S94, S94, (一社)日本毒性学会, 2022年06月, ［査読有り］, ［国内誌］
日本語

Application of three-dimensional Raman imaging to determination of the relationship between cellular localization of diesel exhaust particles and the toxicity
Langying Ou, Akiko Honda, Natsuko Miyasaka, Sakiko Akaji, Issei Omori, Raga Ishikawa, Yinpeng Li, Kayo Ueda, Hirohisa Takano
TOXICOLOGY MECHANISMS AND METHODS, 32, 5, 333, 340, 2022年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Effect of a vegetation fire event ban on hospital visits for respiratory diseases in Upper Northern Thailand
Athicha Uttajug, Kayo Ueda, Xerxes Tesoro Seposo, Akiko Honda, Hirohisa Takano
International Journal of Epidemiology, Oxford University Press (OUP), 2022年02月04日, ［査読有り］, ［国際誌］
研究論文（学術雑誌）,


Upper Northern Thailand (UNT) has been episodically affected by air pollution from vegetation burning, which causes adverse respiratory health effects. However, no study has evaluated the effect of regulatory actions to prohibit vegetation burning on respiratory morbidity. We examined the effect of a burning ban enforced in May 2016 on hospital visits for respiratory diseases in UNT.





This study used data from eight provinces in UNT. Analyses were conducted for January to April of 2014–2016 (before ban enforcement) and January to April of 2017–2018 (after ban enforcement). Particulate matter of 10 microns in diameter or smaller (PM10) concentrations, numbers of satellite fire hotspots and age-standardized rates of hospital visits for respiratory diseases before and after ban enforcement were compared. The effect of the ban on hospital visits for respiratory diseases was evaluated using an interrupted time-series analysis controlled for season-specific temporal trends, day of week, public holiday, temperature, relative humidity, number of hospitals and offset population, with gastrointestinal diseases as a negative control. A meta-analysis was performed to pool province-specific effect estimates.





The daily average PM10 concentration and the number of fire hotspots decreased after ban enforcement in all provinces in UNT, with percent changes ranging from 5.3 to 34.3% and 14.3 to 81.5%, respectively. The adjusted pooled effect estimates of hospital visits for respiratory diseases decreased by 9.1% (95% CI: 5.1, 12.9), whereas a null association was observed for gastrointestinal diseases.





The burning ban had a positive impact on both air pollution levels and rates of hospital visits for respiratory diseases in UNT.

Long-term air pollution exposure and decreased kidney function: A longitudinal cohort study in Bangkok Metropolitan Region, Thailand from 2002 to 2012.
Kanawat Paoin, Kayo Ueda, Prin Vathesatogkit, Thammasin Ingviya, Suhaimee Buya, Racha Dejchanchaiwong, Arthit Phosri, Xerxes Tesoro Seposo, Chagriya Kitiyakara, Nisakron Thongmung, Akiko Honda, Hirohisa Takano, Piyamitr Sritara, Perapong Tekasakul
Chemosphere, 287, Pt 1, 132117, 132117, 2022年01月, ［査読有り］, ［国際共著］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Kidney dysfunction is considered a cardiovascular risk factor. However, few longitudinal studies have examined the effects of air pollution on kidney function. We evaluated associations between long-term air pollution exposure and estimated glomerular filtration rate (eGFR) using data from a cohort of the Electricity Generating Authority of Thailand (EGAT) study in Bangkok Metropolitan Region, Thailand. METHODS: This longitudinal study included 1839 subjects (aged 52-71 years in 2002) from the EGAT1 cohort study during 2002-2012. eGFR, based on creatinine, was measured in 2002, 2007, and 2012. Annual mean concentrations of air pollutants (i.e., particulate matter with an aerodynamic diameter ≤10 μm (PM10), ozone (O3), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO)) prior to a measurement of creatinine were assessed with the ordinary kriging method. Mixed-effect linear regression models were used to assess associations between air pollutants and eGFR, while controlling for potential covariates. eGFR values are expressed as percent change per interquartile range (IQR) increments of each pollutant. RESULTS: Lower eGFR was associated with higher concentrations of PM10 (-1.99%, 95% confidence interval (CI): -3.33, -0.63), SO2 (-4.89%, 95%CI: -6.69, -3.07), and CO (-0.97%, 95%CI: -1.96, 0.03). However, after adjusting for temperature, relative humidity, PM10, and SO2, no significant association was observed between CO and eGFR. CONCLUSIONS: Our findings support the hypothesis that long-term exposure to high concentrations of PM10 and SO2 is associated with the progression of kidney dysfunction in subjects of the EGAT cohort study.

PM2.5の測定法と動態　　　　　　　　　　　　　　　
山神 真紀子, 池盛 文数, 久恒 邦裕, 中島 寛則, 上田 佳代, 若松 伸司, 長田 和雄
大気環境学会誌, 57, 1, A18, A20, (公社)大気環境学会, 2022年01月, ［査読有り］, ［国内誌］
日本語

Burden of cancer attributable to air pollution in Japan in 2015
Megumi Hori, Kota Katanoda, Kayo Ueda, Tomoki Nakaya, Eiko Saito, Sarah Krull Abe, Mayo Hirabayashi, Tomohiro Matsuda, Manami Inoue
GHM Open, 1, 2, 76, 84, National Center for Global Health and Medicine (JST), 2021年12月31日
研究論文（学術雑誌）

Exposure to PM2.5 and Lung Function Growth in Pre- and Early Adolescent Schoolchildren.
Toru Takebayashi, Masataka Taguri, Hiroshi Odajima, Shuichi Hasegawa, Keiko Asakura, Ai Milojevic, Ayano Takeuchi, Satoshi Konno, Miki Morikawa, Teruomi Tsukahara, Kayo Ueda, Yasufumi Mukai, Mihoko Minami, Yuuji Nishiwaki, Takesumi Yoshimura, Masaharu Nishimura, Hiroshi Nitta
Annals of the American Thoracic Society, 19, 5, 763, 772, 2021年10月21日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, RATIONALE: Epidemiological evidence indicates ambient exposure to PM2.5 have adverse effects on lung function growth in children, but it is not actually clear whether exposure to low level PM2.5 results in long-term decrements in lung function growth in pre- to early adolescent schoolchildren. OBJECTIVES: To examine long-term effects of PM2.5 within the 4-yr concentration range of 10 to 19 μg/m3 on lung function growth with repeated measurements of lung function tests. METHODS: Longitudinal analysis of 6,233 lung function measurements in 1,466 participants aged 8 to 12 from 16 school communities in 10 cities around Japan, covering a board area of the country to represent concentration range of PM2.5, was done with multilevel linear regression model. Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and maximal expiratory flow at 50% of FVC (V50) were used as lung function indicators to examine effects of 10-μg/m3 increases in PM2.5 concentration on relative growth per 10-cm increase in height. RESULTS: Overall annual mean PM2.5 concentration was 13.5 μg/m3 (range: 10.4 to 19.0 µg/m3). We found no association between any of the lung function growth indicators and increases in PM2.5 levels in children of either sex, even after controlling for potential confounders. Analysis with two-pollutant models with O3 or NO2 did not change the null results. CONCLUSIONS: This nationwide longitudinal study suggests that concurrent, long-term exposure to PM2.5 at concentrations ranging from 10.4 to 19.0 μg/m3 has little effect on lung function growth in pre-adolescent boys and pre- to early adolescent girls. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (https://creativecommons.org/licenses/by-ncnd/4.0/).

子宮内膜症既往と心血管疾患発症の関連 Japan Nurses' Health Studyでの検討　　　　　　　　　　　　　　　
長井 万恵, 上田 佳代, 清原 裕, 磯 博康, 安井 敏之, 倉林 工, 井手野 由季, 林 邦彦
日本女性医学学会雑誌, 29, 1, 96, 96, (一社)日本女性医学学会, 2021年10月, ［査読有り］, ［国内誌］
日本語

PM2.5の測定法と動態　　　　　　　　　　　　　　　
山神 真紀子, 池盛 文数, 久恒 邦裕, 中島 寛則, 上田 佳代, 若松 伸司, 長田 和雄
大気環境学会年会講演要旨集, 62回, 88, 89, (公社)大気環境学会, 2021年09月
日本語

Long-term air pollution exposure and serum lipids and blood sugar: A longitudinal cohort study from the electricity generating authority of Thailand study
Kanawat Paoin, Kayo Ueda, Prin Vathesatogkit, Thammasin Ingviya, Suhaimee Buya, Arthit Phosri, Xerxes Tesoro Seposo, Nisakron Thongmung, Teerapat Yingchoncharoen, Akiko Honda, Hirohisa Takano, Piyamitr Sritara
Atmospheric Environment, 259, 118515, 118515, Elsevier BV, 2021年08月, ［査読有り］, ［国際共著］, ［国際誌］
研究論文（学術雑誌）

Effects of long-term air pollution exposure on ankle-brachial index and cardio-ankle vascular index: A longitudinal cohort study using data from the Electricity Generating Authority of Thailand study
Kanawat Paoin, Kayo Ueda, Prin Vathesatogkit, Thammasin Ingviya, Suhaimee Buya, Arthit Phosri, Xerxes Tesoro Seposo, Nisakron Thongmung, Teerapat Yingchoncharoen, Akiko Honda, Hirohisa Takano, Piyamitr Sritara
International Journal of Hygiene and Environmental Health, 236, 113790, 113790, Elsevier {BV}, 2021年07月, ［査読有り］, ［国際共著］, ［国際誌］
研究論文（学術雑誌）, 13712130

Investigation of association between smoke haze and under-five mortality in Malaysia, accounting for time lag, duration and intensity
Vera Ling Hui Phung, Kayo Ueda, Mazrura Sahani, Xerxes Tesoro Seposo, Wan Rozita Wan Mahiyuddin, Akiko Honda, Hirohisa Takano
International Journal of Epidemiology, Oxford University Press (OUP), 2021年06月20日, ［査読有り］, ［国際共著］, ［国際誌］
研究論文（学術雑誌）,


Studies on the association between smoke haze (hereafter ‘haze’) and adverse health effects have increased in recent years due to extreme weather conditions and the increased occurrence of vegetation fires. The possible adverse health effects on under-five children (U5Y) is especially worrying due to their vulnerable condition. Despite continuous repetition of serious haze occurrence in Southeast Asia, epidemiological studies in this region remained scarce. Furthermore, no study had examined the association accounting for three important aspects (time lag, duration and intensity) concurrently.





This study aimed to examine the association between haze and U5Y mortality in Malaysia, considering time lag, duration and intensity of exposure.





We performed a time-stratified case-crossover study using a generalized additive model to examine the U5Y mortality related to haze in 12 districts in Malaysia, spanning from 2014 to 2016. A ‘haze day’ was characterized by intensity [based on concentrations of particulate matter (PM)] and duration (continuity of haze occurrence, up to 3 days).





We observed the highest but non-significant odds ratios (ORs) of U5Y mortality at lag 4 of Intensity-3. Lag patterns revealed the possibility of higher acuteness at prolonged and intensified haze. Stratifying the districts by the 95th-percentile of PM distribution, the ‘low’ category demonstrated marginal positive association at Intensity-2 Duration-3 [OR: 1.210 (95% confidence interval: 1.000, 1.464)].





We found a null association between haze and U5Y mortality. The different lag patterns of the association observed over different duration and intensity suggest consideration of these aspects in future studies.


, 13712123

Fine particulate matter and out-of-hospital cardiac arrest of respiratory origin.
Sunao Kojima, Takehiro Michikawa, Kunihiko Matsui, Hisao Ogawa, Shin Yamazaki, Hiroshi Nitta, Akinori Takami, Kayo Ueda, Yoshio Tahara, Naohiro Yonemoto, Hiroshi Nonogi, Ken Nagao, Takanori Ikeda, Yoshio Kobayashi
The European respiratory journal, 57, 6, 2021年06月, ［査読有り］, ［国際誌］
英語

Association between ambient temperature and intentional injuries: A case-crossover analysis using ambulance transport records in Japan
Ryusei Kubo, Kayo Ueda, Xerxes Seposo, Akiko Honda, Hirohisa Takano
Science of The Total Environment, 774, 145511, 145511, Elsevier BV, 2021年06月, ［査読有り］, ［責任著者］, ［国際誌］
研究論文（学術雑誌）

名古屋市における2003年度から2018年度のPM2.5濃度の変動と発生源対策
山神真紀子, 池盛文数, 中島寛則, 久恒邦裕, 上田佳代, 若松伸司, 長田和雄
エアロゾル科学・技術研究討論会(CD-ROM), 12, 5, 2021年05月, ［査読有り］
英語, 13712126

Association between PM10 from vegetation fire events and hospital visits by children in upper northern Thailand
Athicha Uttajug, Kayo Ueda, Kei Oyoshi, Akiko Honda, Hirohisa Takano
Science of The Total Environment, 764, 142923, 142923, Elsevier BV, 2021年04月, ［査読有り］, ［責任著者］, ［国際共著］
英語, 研究論文（学術雑誌）, Few studies have focused on the effects of exposure to air pollutants from vegetation fire events (including forest fire and the burning of crop residues) among children. In this study we aimed to investigate the association between PM₁₀ concentrations and hospital visits by children to address respiratory disease, conjunctivitis, and dermatitis. We examined and compared these associations by the presence of vegetation fire events on a given day (burning, non-burning, and mixed) across the upper northern region of Thailand from 2014 through 2018. A vegetation burning was defined when a fire hotspot (obtained from NASA-MODIS) exceeded the 90th percentile of the entire region and PM₁₀ concentration was over 100 μg/m³. To determine the association between hospital visits among children with PM₁₀ concentrations on burning and non-burning days, we performed a time-stratified case-crossover analysis fitted with conditional logistic regression for each province. A random-effects meta-analysis was applied to pool province-specific effect estimates. The number of burning days ranged from 64 to 139 days across eight provinces. A 10 μg/m³ increase in PM₁₀ concentration on a burning day was associated with a respiratory disease-related hospital visit at lag 0 (OR = 1.01 (95% CIs: 1.00, 1.02)). This association was not observed for hospital visits related to conjunctivitis and dermatitis. A positive association was also observed between PM₁₀ concentration on non-burning days and hospital visits related to respiratory disease at lag 0 (OR = 1.03 (95% CIs: 1.02, 1.04)). Hospital visits for conjunctivitis and dermatitis were significantly associated with PM₁₀ concentration at lag 0 on both non-burning and mixed days., 13712123

Long-Term Exposure to Particulate Matter and Mortality from Cardiovascular Diseases in Japan: The Ibaraki Prefectural Health Study (IPHS)
Ayano Takeuchi, Yuji Nishiwaki, Tomonori Okamura, Ai Milojevic, Kayo Ueda, Keiko Asakura, Toru Takebayashi, Shuichi Hasegawa, Toshimi Sairenchi, Fujiko Irie, Hitoshi Ota, Hiroshi Nitta
Journal of Atherosclerosis and Thrombosis, 28, 3, 230, 240, Japan Atherosclerosis Society, 2021年03月01日, ［査読有り］, ［国内誌］
研究論文（学術雑誌）

Effects of exposure to chemical components of fine particulate matter on mortality in Tokyo: A case-crossover study
Takehiro Michikawa, Shin Yamazaki, Kayo Ueda, Ayako Yoshino, Seiji Sugata, Shinji Saito, Junya Hoshi, Hiroshi Nitta, Akinori Takami
Science of The Total Environment, 755, 142489, 142489, Elsevier BV, 2021年02月, ［査読有り］, ［国際誌］
研究論文（学術雑誌）, 13712125

Long-term air pollution exposure and self-reported morbidity: A longitudinal analysis from the Thai cohort study (TCS)
Kanawat Paoin, Kayo Ueda, Thammasin Ingviya, Suhaimee Buya, Arthit Phosri, Xerxes Tesoro Seposo, Sam-ang Seubsman, Matthew Kelly, Adrian Sleigh, Akiko Honda, Hirohisa Takano, Jaruwan Chokhanapitak, Chaiyun Churewong, Suttanit Hounthasarn, Suwanee Khamman, Daoruang Pandee, Suttinan Pangsap, Tippawan Prapamontol, Janya Puengson, Wimalin Rimpeekool, Yodyiam Sangrattanakul, Sam-ang Seubsman, Boonchai Somboonsook, Nintita Sripaiboonkij, Pathumvadee Somsamai, Benjawan Tawatsupa, Arunrat Tangmunkongvorakul, Duangkae Vilainerun, Wanee Wimonwattanaphan, Chris Bain, Emily Banks, Cathy Banwell, Janneke Berecki-Gisolf, Bruce Caldwell, Gordon Carmichael, Tarie Dellora, Jane Dixon, Sharon Friel, David Harley, Susan Jordan, Matthew Kelly, Tord Kjellstrom, Lynette Lim, Roderick McClure, Anthony McMichael, Tanya Mark, Adrian Sleigh, Lyndall Strazdins, Tam Tran, Vasoontara Yiengprugsawan, Jiaying Zhao
Environmental Research, 192, 110330, 110330, Elsevier BV, 2021年01月, ［査読有り］, ［責任著者］, ［国際共著］, ［国際誌］
研究論文（学術雑誌）

Short-term effects of air pollution on daily single- and co-morbidity cardiorespiratory outpatient visits.
Xerxes Seposo, Kayo Ueda, Seiji Sugata, Ayako Yoshino, Akinori Takami
The Science of the total environment, 729, 138934, 138934, 2020年08月10日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Several studies have noted that the existence of comorbidities lead to an increase in the risk of premature mortality and morbidity. Most of the studies examining the effects of air pollution on comorbidity visits were from Northern American countries, with scarce literature from Asia. This study contributes to existing, yet limited understanding of air pollution-comorbidity by examining the effects of daily air pollutants on outpatient single morbidity and comorbid cardiorespiratory visits in Japan. A total of 1,452,505 outpatient cardiorespiratory visits were recorded among the 21 Japanese cities from 2013 to 2016. Daily outpatient cardiorespiratory visit data were obtained from a health insurance claims database managed by the Japan Medical Data Center Co., Ltd. (JMDC). A time-stratified case crossover analysis coupled with Generalized Additive Mixed Model was used to analyze the association of daily air pollutants (particulate matter 2.5 μm or less in diameter, ozone and nitrogen dioxide) on daily single (respiratory and cardiovascular) and comorbidity health outcomes. We further examined single and cumulative effects for 0-3 and 0-14 lag periods. Ozone, NO2, and PM2.5 were positively associated with cardiorespiratory visits in either shorter or longer lags, with more apparent comorbidity associations with NO2 exposure. A 10-unit increase in NO2, after adjusting for ozone, was associated with a 2.24% (95% CI: 1.34-3.15) and 6.49% (95% CI: 5.00-8.01) increase in comorbidity visit at Lag 0 (of Lag 0-3) and cumulative lag 0-3, respectively. Our results contribute to existing evidence suggesting that short-term and extended exposure to air pollution elicit health risks on cardiovascular, respiratory and comorbid clinic visits. Exposure to NO2, in particular, was associated with increase in the risk of single and comorbidity cardiorespiratory visits. Results can be potentially utilized for both individual health (e.g. risk population health management) and health facility management (e.g. health visit influx determination).

A development of reduction scenarios of the short-lived climate pollutants (SLCPs) for mitigating global warming and environmental problems
Teruyuki Nakajima, Toshimasa Ohara, Toshihiko Masui, Toshihiko Takemura, Kei Yoshimura, Daisuke Goto, Tatsuya Hanaoka, Syuichi Itahashi, Gakuji Kurata, Jun-ichi Kurokawa, Takashi Maki, Yuji Masutomi, Makiko Nakata, Tomoko Nitta, Xerxes Seposo, Kengo Sudo, Chieko Suzuki, Kentaroh Suzuki, Haruo Tsuruta, Kayo Ueda, Shingo Watanabe, Yong Yu, Keiya Yumimoto, Shuyun Zhao
PROGRESS IN EARTH AND PLANETARY SCIENCE, 7, 1, 2020年07月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Hourly association between ambient PM2.5 and emergency ambulance dispatches in 11 cities in Japan.
Vera Ling Hui Phung, Kayo Ueda, Xerxes Seposo, Akinori Takami, Seiji Sugata, Ayako Yoshino, Takehiro Michikawa, Shin Yamazaki, Akiko Honda, Hirohisa Takano
Environmental research, 185, 109448, 109448, 2020年06月, ［査読有り］, ［国際誌］
英語, Numerous epidemiological studies have demonstrated that short-term exposure to ambient PM2.5 increases mortality and morbidity. Investigating the association using hourly ambient PM2.5 exposure may provide important insights, as current evidence is limited mostly to daily lag term. This study aimed to investigate the hourly association between ambient PM2.5 concentrations and all-cause emergency ambulance dispatches (EAD) in 11 cities in Japan. We used a time-stratified case-crossover design and examined the hourly lags of ambient PM2.5 up to 24 h (unconditional distributed lags and moving average lags) using a conditional Poisson regression model. A significant increase in all-cause EAD was observed at lag 0 h [relative risk (RR): 1.0037 (95% CI: 1.0000, 1.0074)] and all moving average lags. The highest RR was observed within the first 6 h (at lag 0-5 h) [RR: 1.0091 (95% CI: 1.0068, 1.0114)], with a slight ascending pattern. This was followed by a descending pattern at lags 0-11, 0-17, and 0-23 h, but significant positive RR was observed even at lag 0-23 h, when the lowest RR was observed [RR: 1.0072 (95% CI: 1.0044, 1.0100)]. Though similar pattern was observed among the elderly, a different pattern was observed among the children (gradually ascending pattern). We conclude that all-cause EAD could be triggered by ambient PM2.5 exposure with very short lags.

Association of Fine Particulate Matter Exposure With Bystander-Witnessed Out-of-Hospital Cardiac Arrest of Cardiac Origin in Japan.
Sunao Kojima, Takehiro Michikawa, Kunihiko Matsui, Hisao Ogawa, Shin Yamazaki, Hiroshi Nitta, Akinori Takami, Kayo Ueda, Yoshio Tahara, Naohiro Yonemoto, Hiroshi Nonogi, Ken Nagao, Takanori Ikeda, Naoki Sato, Hiroyuki Tsutsui
JAMA network open, 3, 4, e203043, 2020年04月01日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Importance: Out-of-hospital cardiac arrests (OHCAs) are a major public health concern and a leading cause of death worldwide. Exposure to ambient air pollution is associated with increases in morbidity and mortality and has been recognized as a leading contributor to global disease burden. Objective: To examine the association between short-term exposure to particulate matter with a diameter of 2.5 μm or smaller (PM2.5) and the incidence of OHCAs of cardiac origin and with the development of initial cardiac arrest rhythm. Design, Setting, and Participants: This case-control study used data from cases registered between January 1, 2005, and December 31, 2016, in the All-Japan Utstein Registry, a prospective, nationwide, population-based database for OHCAs across all 47 Japanese prefectures. These OHCA cases included patients who had bystander-witnessed OHCAs and for whom emergency medical services responders initiated resuscitation before hospital transfer. A case-crossover design was employed for the study analyses. A prefecture-specific, conditional logistic regression model to estimate odds ratios was applied, and a random-effects meta-analysis was used to obtain prefecture-specific pooled estimates. All analyses were performed from May 7, 2019, to January 23, 2020. Main Outcomes and Measures: The main outcome was the association of short-term PM2.5 exposure with the incidence of bystander-witnessed OHCAs of cardiac origin. The differences in the distribution of initial cardiac arrest rhythm in OHCAs among those with exposure to PM2.5 were also examined. Results: In total, 103 189 OHCAs witnessed by bystanders were included in the final analysis. Among the patients who experienced such OHCAs, the mean (SD) age was 75 (15.5) years, and 62 795 (60.9%) were men. Point estimates of the percentage increase for a 10-μg/m3 increase in PM2.5 at lag0-1 (difference in mean PM2.5 concentrations measured on the case day and 1 day before) demonstrated a statistically significantly higher incidence of OHCA across most of the 47 prefectures, without significant heterogeneity (I2 = 20.1%; P = .12). A stratified analysis found an association between PM2.5 exposure and OHCAs (% increase, 1.6; 95% CI, 0.1%-3.1%). An initial shockable rhythm, such as ventricular fibrillation or pulseless ventricular tachycardia (% increase, 0.6; 95% CI, -2.0% to 3.2%), was not associated with PM2.5 exposure. However, an initial nonshockable rhythm, such as pulseless electrical activity and asystole, was associated with PM2.5 exposure (% increase, 1.4; 95% CI, 0.1%-2.7%). Conclusions and Relevance: Findings from this study suggest that increased PM2.5 concentration is associated with bystander-witnessed OHCA of cardiac origin that commonly presents with nonshockable rhythm. The results support measures to reduce PM2.5 exposure to prevent OHCAs of cardiac origin.

Health effects of PM2.5 sources on children's allergic and respiratory symptoms in Fukuoka, Japan.
Taichi Sugiyama, Kayo Ueda, Xerxes Tesoro Seposo, Ayako Nakashima, Makoto Kinoshita, Hiroko Matsumoto, Fumikazu Ikemori, Akiko Honda, Hirohisa Takano, Takehiro Michikawa, Hiroshi Nitta
The Science of the total environment, 709, 136023, 136023, 2020年03月20日, ［査読有り］, ［責任著者］, ［国際誌］
英語, Exposure to fine particulate matter (PM2.5) is a potential aggravating factor for respiratory and allergic diseases. However, which PM2.5 sources are associated with such diseases remains unclear. This study aimed to investigate the association of PM2.5 sources with allergic and respiratory symptoms in schoolchildren. PM2.5 samples were collected in Fukuoka during the spring in 2014 and 2015. Asian dust was observed in 2014. Ion components, elemental components, and organic components were analyzed. Positive matrix factorization (PMF) was conducted to calculate PM2.5 concentrations from each source. Mixed logistic regression analysis with a random intercept for each schoolchild was performed to evaluate the association of components and sources with symptoms. Among 2317 schoolchildren, the mean prevalence was 28.9%, 23.6%, 11.2%, and 11.4% for lower respiratory, nasal, ocular, and skin symptoms, respectively. PMF identified the following six PM2.5 sources "Secondary sulfate and coal combustion", "Secondary nitrate", "Heavy oil combustion", "Sea salt", "Soil" and "Traffic emission". An interquartile range of PM2.5 mass was associated with nasal (Odds ratios 1.08, 95% confidence interval [1.03, 1.13]), ocular (1.10, [1.04, 1.16]), and skin symptoms (1.13, [1.06, 1.20]). Among the source factors, "Heavy oil combustion" was significantly associated with nasal symptom (1.11, [1.05, 1.18]) while "Sea salt" was associated with nasal (1.06, [1.02, 1.11]) and skin (1.073, [1.01, 1.14]) symptoms. We found "Soil", which might be affected by Asian dust, was associated with ocular (1.07, [1.03, 1.10]) and skin (1.05, [1.01, 1.08]) symptoms. Further studies in other seasons or places are needed to clarify the influence of PM2.5 sources on children's health.

Association between Asian dust exposure and respiratory function in children with bronchial asthma in Nagasaki Prefecture, Japan.
Takahiro Nakamura, Yuji Nishiwaki, Kunio Hashimoto, Ayano Takeuchi, Tasuku Kitajima, Kazuhiro Komori, Kasumi Tashiro, Hideki Hasunuma, Kayo Ueda, Atsushi Shimizu, Hiroshi Odajima, Hiroyuki Moriuchi, Masahiro Hashizume
Environmental health and preventive medicine, 25, 1, 8, 8, 2020年03月04日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Studies on the adverse effects of Asian dust (AD) on respiratory function in children are scarce. The objective of this study was to examine the association between AD and respiratory function by measuring peak expiratory flow rates (PEFRs) in asthmatic children. METHODS: The study was carried out from March to May from 2014 through 2016. One hundred ten children with bronchial asthma were recruited from four hospitals in the Goto Islands and south Nagasaki area in Nagasaki prefecture. The parents were asked to record their children's PEFRs every morning/evening and clinical symptoms in an asthma diary. AD was assessed from light detection and ranging data, and a linear mixed-effects model was used to estimate the effects of AD on daily PEFR. Time-stratified case-crossover analyses were performed to examine the association between AD and asthma attacks defined by reduction levels in PEFR. RESULTS: AD was detected on 11 days in the Goto Islands, and on 23 days in the south Nagasaki area. After adjusting for age, sex, temperature, and daily oxidants, we found a consistent association between AD and a 1.1% to 1.7% decrease in PEFR in the mornings and a 0.7% to 1.3% decrease in the evenings at a lag of 0 to 5 days. AD was not associated with the number of asthma attacks, respiratory symptoms, or other symptoms at any lag days examined. CONCLUSIONS: Exposure to AD was associated with reduced PEFR, although the effects were not large enough to induce clinically apparent symptoms, in clinically well-controlled asthmatic children.

Association between PM2.5 exposure and heart rate variability for the patients with cardiac problems in Japan
Kanawat Paoin, Kayo Ueda, Xerxes Tesoro Seposo, Junichiro Hayano, Ken Kiyono, Norihiro Ueda, Takashi Kawamura, Akiko Honda, Hirohisa Takano
Air Quality, Atmosphere and Health, 13, 3, 339, 347, 2020年03月01日, ［査読有り］, ［責任著者］, ［国際共著］, ［国際誌］
研究論文（学術雑誌）

黄砂および砂漠由来粒子の健康影響
上田 佳代
エアロゾル研究, 35, 1, 27, 32, 日本エアロゾル学会, 2020年, ［招待有り］, ［筆頭著者］, ［国内誌］
日本語, 研究論文（学術雑誌）

For making a declaration of countermeasures against the falling birth rate from the Japanese Society for Hygiene: summary of discussion in the working group on academic research strategy against an aging society with low birth rate
Kyoko Nomura, Kanae Karita, Atsuko Araki, Emiko Nishioka, Go Muto, Miyuki Iwai-Shimada, Mariko Nishikitani, Mariko Inoue, Shinobu Tsurugano, Naomi Kitano, Mayumi Tsuji, Sachiko Iijima, Kayo Ueda, Michihiro Kamijima, Zentaro Yamagata, Kiyomi Sakata, Masayuki Iki, Hiroyuki Yanagisawa, Masashi Kato, Hidekuni Inadera, Yoshihiro Kokubo, Kazuhito Yokoyama, Akio Koizumi, Takemi Otsuki
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 24, 1, UNSP 14, Springer Science and Business Media LLC, 2019年03月, ［査読有り］
英語, 研究論文（学術雑誌）

Effects of ambient air pollution on daily hospital admissions for respiratory and cardiovascular diseases in Bangkok, Thailand
Arthit Phosri, Kayo Ueda, Vera Ling Hui Phung, Benjawan Tawatsupa, Akiko Honda, Hirohisa Takano
SCIENCE OF THE TOTAL ENVIRONMENT, 651, 1144, 1153, ELSEVIER SCIENCE BV, 2019年02月, ［査読有り］, ［責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）

Toward a Declaration to Address Japan's Aging Society with Low Birth Rate: Summary of the Japanese Society for Hygiene's Working Group on Academic Research Strategy against an Aging Society with Low Birth Rate
Kyoko Nomura, Kanae Karita, Atsuko Araki, Emiko Nishioka, Go Muto, Miyuki Iwai-Shimada, Mariko Nishikitani, Mariko Inoue, Shinobu Tsurugano, Naomi Kitano, Mayumi Tsuji, Sachiko Iijima, Kayo Ueda, Michihiro Kamijima, Zentaro Yamagata, Kiyomi Sakata, Masayuki Iki, Hiroyuki Yanagisawa, Masashi Kato, Kazuhito Yokoyama, Akio Koizumi, Takemi Otsuki
Nihon eiseigaku zasshi. Japanese journal of hygiene, 74, 2019年, ［招待有り］, ［国内誌］
研究論文（学術雑誌）

Extract of curry powder and its components protect against diesel exhaust particle-induced inflammatory responses in human airway epithelial cells
Akiko Honda, Sho Ito, Michitaka Tanaka, Takahiro Sawahara, Tomohiro Hayashi, Wataru Fukushima, Gaku Kitamura, Hitomi Kudo, Pratiti Home Chowdhury, Hitoshi Okano, Toshinori Onishi, Yusuke Kawaryu, Makoto Higashihara, Hideki Nakayama, Kayo Ueda, Hirohisa Takano
Food and Agricultural Immunology, 30, 1, 1212, 1224, Informa UK Limited, 2019年01月01日, ［査読有り］
研究論文（学術雑誌）

都市の属性が暑熱による救急搬送リスクに及ぼす影響
小谷和也, 上田佳代, Xerxes Seposo, 小野雅司, 本田晶子, 高野裕久
日本衛生学雑誌, 74, 0, 2019年, ［査読有り］, ［責任著者］, ［国内誌］
日本語, 研究論文（学術雑誌）, OBJECTIVES: In this multicity study, we aimed to elucidate the city-specific factors affecting the association of high ambient temperature with ambulance dispatches due to acute illnesses. METHODS: We used the data of ambulance dispatches in 27 cities in Japan with more than 500,000 population excluding Tokyo, from May to September from 2012 to 2015. We included patients 20 years and older (≥20 years) and stratified them into three age groups (20-59, 60-79, and ≥80 years). We explored the city-specific pattern of the daily relative temperature (in temperature percentiles) and the risk of ambulance dispatches for each age group using a distributed lag nonlinear model and estimated the city-specific relative risks of ambulance dispatches at the 95/99 percentile temperature compared with the 77.6 percentile temperature defined as the reference temperature (Tref). Then, the estimates were combined by performing meta-analyses for each age group. We also applied meta-regression models to explore whether the city-specific characteristics modified the association of temperature with ambulance dispatches. RESULTS: The relative risks of the 95th percentile with respect to Tref were 1.14 (95% confidence interval (CI): 1.12, 1.16), 1.16 (95% CI: 1.13, 1.20), 1.13 (95% CI: 1.10, 1.16), and 1.13 (95% CI: 1.00, 1.16), for all-age (≥20) and age-stratified groups (20-59, 60-79, and ≥80 years), respectively. We observed a higher relative risk for the ≥20 years age group in the cities with higher proportions of single-elderly, single-mother, and single-father households. We also found that the relative risk for the 20-59 years age group was higher in the cities with a higher proportion of blue-collar workers. CONCLUSIONS: The present study provides insights into city-specific characteristics modifying heat-related health effects.

Effect of global atmospheric aerosol emission change on PM2.5-related health impacts.
Xerxes Seposo, Kayo Ueda, Sang Seo Park, Kengo Sudo, Toshihiko Takemura, Teruyuki Nakajima
Global health action, 12, 1, 1664130, 1664130, 2019年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: Previous research has highlighted the importance of major atmospheric aerosols such as sulfate, through its precursor sulfur dioxide (SO2), black carbon (BC), and organic carbon (OC), and their effect on global climate regimes, specifically on their impact on particulate matter measuring ≤ 2.5 μm (PM2.5). Policy regulations have attempted to address the change in these major active aerosols and their impact on PM2.5, which would presumably have a cascading effect toward the change of health risks. Objective: This study aimed to determine how the change in the global emissions of anthropogenic aerosols affects health, particularly through the change in attributable mortality (AN) and years of life lost (YLL). This study also aimed to explore the importance of using AM/YLL in conveying air pollution health impact message. Methods: The Model for Interdisciplinary Research on Climate was used to estimate the gridded atmospheric PM2.5 by changing the emission of SO2, BC, and OC. Next, the emissions were utilized to estimate the associated cause-specific risks via an integrated exposure-response function, and its consequent health indicators, AM and YLL, per country. Results: OC change yielded the greatest benefit for all country income groups, particularly among low-middle-income countries. Utilizing either AM or YLL did not alter the order of benefits among upper-middle and high-income countries (UMIC/HIC); however, using either health indicator to express the order of benefit varied among low- and low-middle-income countries (LIC/LMIC). Conclusions: Global and country-specific mitigation efforts focusing on OC-related activities would yield substantial health benefits. Substantial aerosol emission reduction would greatly benefit high-emitting countries (i.e. China and India). Although no difference is found in the order of health outcome benefits in UMIC/HIC, caution is warranted in using either AM or YLL for health impact assessment in LIC/LMIC.

Health impact assessment of PM2.5-related mitigation scenarios using local risk coefficient estimates in 9 Japanese cities.
Xerxes Seposo, Masahide Kondo, Kayo Ueda, Yasushi Honda, Takehiro Michikawa, Shin Yamazaki, Hiroshi Nitta
Environment international, 120, 525, 534, PERGAMON-ELSEVIER SCIENCE LTD, 2018年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Previous studies have highlighted the negative effects of PM2.5 on mortality, expressed in terms of attributable deaths and life years lost. However, there are very few studies assessing the health impacts of air pollution in terms of economic burden/benefits. This study assessed the health impact of two hypothetical interventions among sex- and age-specific risk populations using a robust risk estimation and economic valuation process. We utilized the sex- and age-stratified daily all-cause mortality together with the daily PM2.5 of the 9 Japanese cities from 2002 to 2008 in estimating the relative risks. The estimated risks were then utilized for the economic valuation of co-benefits/burden with respect to the two hypothetical PM2.5-related mitigation scenarios, in comparison to status quo, namely: i) decrease to Japanese standards, and ii) decrease to WHO standards. Impact of these interventions on health were assessed using the following HIA metrics: attributable mortality, attributable years life lost, and environmental health impact. A 10-μg/m3 increase in PM2.5 would increase the risk by 0.52% (95% CI: -0.91% to 1.99%) for all-cause mortality, with varying risk estimates per subgroup. High economic burdens were estimated at status quo, with particularly distinct burden difference for age-specific mortality; 0.40 trillion yen (0-64 y.o.) and 1.50 trillion yen (>64 y.o.). If stricter standards, relative to status quo, were to be enforced, i.e. WHO standard, there is a potential to yield economic benefits in the same risk population; 0.26 trillion yen (0-64 y.o.) and 0.98 trillion yen (>64 y.o.). We did not observe any substantial difference with the burden and benefit related to sex-specific mortality. Using the estimated local risk coefficients complemented with the valuation of the risks, policymaking entities will have the opportunity to operate their own HIA to assess the relevant air pollution-related health impacts.

Japanese Nationwide Study on the Association between Short-term Exposure to Particulate Matter and Mortality.
T. Michikawa, K. Ueda, A. Takami, S. Sugata, A. Yoshino, H. Nitta, S. Yamazaki
J Epidemiol., 29, 12, JE20180122, 477, 2018年10月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Health impact assessment of PM-related mitigation scenarios using local risk coefficient estimates in 9 Japanese cities
Seposo, Xerxes, Kondo, Masahide, Ueda, Kayo, Honda, Yasushi, Michikawa, Takehiro, Yamazaki, Shin, Nitta, Hiroshi
Environment international, 120, 525, 534, PERGAMON-ELSEVIER SCIENCE LTD, 2018年08月, ［査読有り］
英語, 研究論文（学術雑誌）, Previous studies have highlighted the negative effects of PM on mortality, expressed in terms of attributable deaths and life years lost. However, there are very few studies assessing the health impacts of air pollution in terms of economic burden/benefits. This study assessed the health impact of two hypothetical interventions among sex- and age-specific risk populations using a robust risk estimation and economic valuation process. We utilized the sex- and age-stratified daily all-cause mortality together with the daily PM of the 9 Japanese cities from 2002 to 2008 in estimating the relative risks. The estimated risks were then utilized for the economic valuation of co-benefits/burden with respect to the two hypothetical PM-related mitigation scenarios, in comparison to status quo, namely: i) decrease to Japanese standards, and ii) decrease to WHO standards. Impact of these interventions on health were assessed using the following HIA metrics: attributable mortality, attributable years life lost, and environmental health impact. A 10-μg/m increase in PM would increase the risk by 0.52% (95% CI: -0.91% to 1.99%) for all-cause mortality, with varying risk estimates per subgroup. H

名古屋市におけるPM2.5の化学成分の長期変動(2003〜2017年度)　　　　　　　　　　　　　　　
山神 真紀子, 久恒 邦裕, 池盛 文数, 森 健次, 長田 和雄, 上田 佳代
大気環境学会年会講演要旨集, 59回, 480, 480, (公社)大気環境学会, 2018年08月
日本語

Aqueous and organic extract of PM2.5 collected in different seasons and cities of Japan differently affect respiratory and immune systems
Pratiti Home Chowdhury, Hitoshi Okano, Akiko Honda, Hitomi Kudou, Gaku Kitamura, Sho Ito, Kayo Ueda, Hirohisa Takano
Environmental Pollution, 235, 223, 234, Elsevier Ltd, 2018年04月01日, ［国際誌］
英語, 研究論文（学術雑誌）

Acute Effects of Ambient PM2.5 on All-Cause and Cause-Specific Emergency Ambulance Dispatches in Japan
Vera Ling Hui Phung, Kayo Ueda, Shunji Kasaoka, Xerxes Seposo, Saira Tasmin, Shinichi Yonemochi, Arthit Phosri, Akiko Honda, Hirohisa Takano, Takehiro Michikawa, Hiroshi Nitta
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 15, 2, 307, MDPI, 2018年02月09日, ［査読有り］, ［責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）, Short-term health effects of ambient PM2.5 have been established with numerous studies, but evidence in Asian countries is limited. This study aimed to investigate the short-term effects of PM2.5 on acute health outcomes, particularly all-cause, cardiovascular, respiratory, cerebrovascular and neuropsychological outcomes. We utilized daily emergency ambulance dispatches (EAD) data from eight Japanese cities (2007-2011). Statistical analyses included two stages: (1) City-level generalized linear model with Poisson distribution; (2) Random-effects meta-analysis in pooling city-specific effect estimates. Lag patterns were explored using (1) unconstrained-distributed lags (lag 0 to lag 7) and (2) average lags (lag: 0-1, 0-3, 0-5, 0-7). In all-cause EAD, significant increases were observed in both shorter lag (lag 0: 1.24% (95% CI: 0.92, 1.56)) and average lag 0-1 (0.64% (95% CI: 0.23, 1.06)). Increases of 1.88% and 1.48% in respiratory and neuropsychological EAD outcomes, respectively, were observed at lag 0 per 10 µg/m³ increase in PM2.5. While respiratory outcomes demonstrated significant average effects, no significant effect was observed for cardiovascular outcomes. Meanwhile, an inverse association was observed in cerebrovascular outcomes. In this study, we observed that effects of PM2.5 on all-cause, respiratory and neuropsychological EAD were acute, with average effects not exceeding 3 days prior to EAD onset.

Ambient fine and coarse particles collected at three locations in Japan using cyclone technique affect upper and lower respiratory tract differently and elicit varying immune response
Onishi, Toshinori, Honda, Akiko, Tanaka, Michitaka, Chowdhury, Pratiti Home, Okano, Hitoshi, Okuda, Tomoaki, Shishido, Daiki, Terui, Yoshihiro, Hasagawa, Shuichi, Kameda, Takayuki, Tohno, Susumu, Hayashi, Masahiko, Nishita-Hara, Chiharu, Hara, Keiichiro, Inoue, Kozo, Ueda, Kayo, Takano, Hirohisa
Environmental Pollution, 242, Pt B, 1693, 1701, 2018年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Ambient particulate matter (PM) epidemiologically exacerbates respiratory and immune health, including allergic rhinitis (AR) and bronchial asthma (BA). Although fine and coarse particles can affect respiratory tract, the differences in their effects on the upper and lower respiratory tract and immune system, their underlying mechanism, and the components responsible for the adverse health effects have not been yet completely elucidated. In this study, ambient fine and coarse particles were collected at three different locations in Japan by cyclone technique. Both particles collected at all locations decreased the viability of nasal epithelial cells and antigen presenting cells (APCs), increased the production of IL-6, IL-8, and IL-1β from bronchial epithelial cells and APCs, and induced expression of dendritic and epithelial cell (DEC) 205 on APCs. Differences in inflammatory responses, but not in cytotoxicity, were shown between both particles, and among three locations. Some components such as Ti, Co, Zn, Pb, As, OC (organic carbon) and EC (elemental carbon) showed significant correlations to inflammatory responses or cytotoxicity. These results suggest that ambient fine and coarse particles differently affect nasal and bronchial epithelial cells and immune response, which may depend on particles size diameter, chemical composition and source related particles types.

Effects of high ambient temperature on ambulance dispatches in different age groups in Fukuoka, Japan.
Kazuya Kotani, Kayo Ueda, Xerxes Seposo, Shusuke Yasukochi, Hiroko Matsumoto, Masaji Ono, Akiko Honda, Hirohisa Takano
Global health action, 11, 1, 1437882, 1437882, 2018年, ［査読有り］, ［責任著者］, ［国際誌］
英語, BACKGROUND: The elderly population has been the primary target of intervention to prevent heat-related illnesses. According to the literature, the highest risks have been observed among the elderly in the temperature-mortality relationship. However, findings regarding the temperature-morbidity relationship are inconsistent. OBJECTIVES: This study aimed to examine the association of temperature with ambulance dispatches due to acute illnesses, stratified by age group. Specifically, we explored the optimum temperature, at which the relative health risks were found to be the lowest, and quantified the health risk associated with higher temperatures among different age groups. METHODS: We used the data for ambulance dispatches in Fukuoka, Japan, during May and September from 2005 to 2012. The data were grouped according to age in 20-year increments. We explored the pattern of the association of ambulance dispatches with temperature using a smoothing spline curve to identify the optimum temperature for each age group. Then, we applied a distributed lag nonlinear model to estimate the risks of the 85th-95th percentile temperature relative to the overall optimum temperature, for each age group. RESULTS: The relative risk of ambulance dispatches at the 85th and 95th percentile temperature for all ages was 1.08 [95% confidence interval (CI): 1.05, 1.12] and 1.12 (95% CI: 1.08, 1.16), respectively. In comparison, among age groups, the optimum temperature was observed as 25.0°C, 23.2°C, and 25.3°C for those aged 0-19, 60-79, and ≥80, respectively. The optimum temperature could not be determined for those aged 20-39 and 40-59. The relative risks of high temperature tended to be higher for those aged 20-39 and 40-59 than those for other age groups. CONCLUSIONS: We did not find any definite difference in the effect of high temperature on ambulance dispatches for different age groups. However, more measures should be taken for younger and middle-aged people to avoid heat-related illnesses.

Sensitivities of Simulated Source Contributions and Health Impacts of PM2.5 to Aerosol Models
Yu Morino, Kayo Ueda, Akinori Takami, Tatsuya Nagashima, Kiyoshi Tanabe, Kei Sato, Tadayoshi Noguchi, Toshinori Ariga, Keisuke Matsuhashi, Toshimasa Ohara
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 51, 24, 14273, 14282, 2017年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Aerosol Health Effects from Molecular to Global Scales
Manabu Shiraiwa, Kayo Ueda, Andrea Pozzer, Gerhard Lammel, Christopher J. Kampf, Akihiro Fushimi, Shinichi Enami, Andrea M. Arangio, Janine Froehlich-Nowoisky, Yuji Fujitani, Akiko Furuyama, Pascale S. J. Lakey, Jos Lelieveld, Kurt Lucas, Yu Morino, Ulrich Poeschl, Satoshi Takaharna, Akinori Takami, Haijie Tong, Bettina Weber, Ayako Yoshino, Kei Sato
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 51, 23, 13545, 13567, 2017年12月, ［査読有り］, ［国際共著］, ［国際誌］
英語, 研究論文（学術雑誌）

Asian dust exposure triggers acute myocardial infarction
Sunao Kojima, Takehiro Michikawa, Kayo Ueda, Tetsuo Sakamoto, Kunihiko Matsui, Tomoko Kojima, Kenichi Tsujita, Hisao Ogawa, Hiroshi Nitta, Akinori Takami
EUROPEAN HEART JOURNAL, 38, 43, 3202, 3208, 2017年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Synergistic effect of Carbon nuclei and Polyaromatic hydrocarbons on respiratory and immune responses.
P H Chowdhury, G Kitamura, A Honda, T Sawahara, T Hayashi, W Fukushima, H Kudou, S Ito, S Yoshida, T Ichinose, K Ueda, H Takano
Environmental Toxicology, 32, 9, 2172, 2181, 2017年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Blood pressure-lowering effect of Shinrin-yoku (Forest bathing): a systematic review and meta-analysis
Yuki Ideno, Kunihiko Hayashi, Yukina Abe, Kayo Ueda, Hiroyasu Iso, Mitsuhiko Noda, Jung-Su Lee, Shosuke Suzuki
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 17, 1, 409, 2017年08月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Interactive effects of specific fine particulate matter compositions and airborne pollen on frequency of clinic visits for pollinosis in Fukuoka, Japan
Arthit Phosri, Kayo Ueda, Saira Tasmin, Reiko Kishikawa, Masahiko Hayashi, Keiichiro Hara, Yamato Uehara, Vera Ling Hui Phung, Shusuke Yasukouchi, Shoko Konishi, Akiko Honda, Hirohisa Takano
ENVIRONMENTAL RESEARCH, 156, 411, 419, 2017年07月, ［査読有り］, ［責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）

Synergic effects of 9,10-phenanthrenequinone and cadmium on pro-inflammatory responses in airway epithelial cells
Akiko Honda, Pratiti Home Chowdhury, Sho Ito, Hitoshi Okano, Toshinori Onishi, Yusuke Kawaryu, Kayo Ueda, Hirohisa Takano
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 52, 276, 279, 2017年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Biological factor related to Asian sand dust particles contributes to the exacerbation of asthma
Akiko Honda, Takahiro Sawahara, Tomohiro Hayashi, Kenshi Tsuji, Wataru Fukushima, Mizuki Oishi, Gaku Kitamura, Hitomi Kudo, Sho Ito, Seiichi Yoshida, Takamichi Ichinose, Kayo Ueda, Hirohisa Takano
JOURNAL OF APPLIED TOXICOLOGY, 37, 5, 583, 590, 2017年05月, ［査読有り］
英語, 研究論文（学術雑誌）

Effects of Components of PM2.5 Collected in Japan on the Respiratory and Immune Systems
Akiko Honda, Wataru Fukushima, Mizuki Oishi, Kenshi Tsuji, Takahiro Sawahara, Tomohiro Hayashi, Hitomi Kudo, Yuji Kashima, Katsuyuki Takahashi, Hideki Sasaki, Kayo Ueda, Hirohisa Takano
INTERNATIONAL JOURNAL OF TOXICOLOGY, 36, 2, 153, 164, 2017年03月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Short-Term Exposure to Fine Particulate Matter and Risk of Ischemic Stroke
Ryu Matsuo, Takehiro Michikawa, Kayo Ueda, Tetsuro Ago, Hiroshi Nitta, Takanari Kitazono, Masahiro Kamouchi
STROKE, 47, 12, 3032, 3034, 2016年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Asian Dust and Pediatric Emergency Department Visits Due to Bronchial Asthma and Respiratory Diseases in Nagasaki, Japan
Takahiro Nakamura, Masahiro Hashizume, Kayo Ueda, Atsushi Shimizu, Ayano Takeuchi, Tatsuhiko Kubo, Kunio Hashimoto, Hiroyuki Moriuchi, Hiroshi Odajima, Tasuku Kitajima, Kasumi Tashiro, Kunio Tomimasu, Yuji Nishiwaki
JOURNAL OF EPIDEMIOLOGY, 26, 11, 593, 601, 2016年11月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Short-term exposure to ambient particulate matter and emergency ambulance dispatch for acute illness in Japan
Saira Tasmin, Kayo Ueda, Andrew Stickley, Shinya Yasumoto, Vera Ling Hui Phung, Mizuki Oishi, Shusuke Yasukouchi, Yamato Uehara, Takehiro Michikawa, Hiroshi Nitta
SCIENCE OF THE TOTAL ENVIRONMENT, 566, 528, 535, 2016年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Estimation of excess mortality due to long-term exposure to PM2.5 in Japan using a high-resolution model for present and future scenarios
Daisuke Goto, Kayo Ueda, Chris Fook Sheng Ng, Akinori Takami, Toshinori Ariga, Keisuke Matsuhashi, Teruyuki Nakajima
ATMOSPHERIC ENVIRONMENT, 140, 320, 332, 2016年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Heat-related mortality: Effect modification and adaptation in Japan from 1972 to 2010
Chris Fook Sheng Ng, Melanie Boeckmann, Kayo Ueda, Hajo Zeeb, Hiroshi Nitta, Chiho Watanabe, Yasushi Honda
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 39, 234, 243, 2016年07月, ［査読有り］, ［国際共著］, ［国際誌］
英語, 研究論文（学術雑誌）

Cross-sectional association between exposure to particulate matter and inflammatory markers in the Japanese general population.
T Michikawa, T Okamura, H Nitta, Y Nishiwaki, T Takebayashi, K Ueda, A Kadota, A Fujiyoshi, T Ohkubo, H Ueshima, A Okayama, K Miura
Environmental Pollution, 213, 460, 467, 2016年06月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Associations Between Fine Particulate Matter Components and Daily Mortality in Nagoya, Japan
Kayo Ueda, Makiko Yamagami, Fumikazu Ikemori, Kunihiro Hisatsune, Hiroshi Nitta
JOURNAL OF EPIDEMIOLOGY, 26, 5, 249, 257, 2016年05月, ［査読有り］, ［筆頭著者］, ［国内誌］
英語, 研究論文（学術雑誌）

PM₂.₅による健康影響 : 循環器疾患 (特集 微小粒子状物質PM₂.₅ : 基礎を知り,対策を考える)
上田 佳代
保健の科学, 58, 9, 596, 600, 杏林書院, 2016年01月
日本語

大気中微小粒子状物質の長期曝露が死亡に及ぼす影響―疫学研究における曝露と健康影響の評価に関する系統的レビューとメタ解析―
上田 佳代, Saira Tasmin, 高見 昭憲, 五藤 大輔, 大石 瑞樹, Vera Ling Hui Phung, 安河内 秀輔, Pratiti Home Chowdhury
大気環境学会誌, 51, 6, 245, 256, 公益社団法人 大気環境学会, 2016年01月, ［査読有り］
日本語, 研究論文（学術雑誌）,

大気中PM_2.5の長期曝露が死亡に及ぼす影響についての疫学知見について系統的文献レビューを行い、曝露評価方法についてまとめるとともに、メタ解析を行い、結果を統合した。1990年1月1日～2015年12月31日の間に公表されている英語の論文について、曝露を示す用語として"air pollutant(s)"、"air pollution"、"particulate matter"、"PM2.5"、"PM10"を、健康アウトカムを示す用語として"mortality"、"death"、長期曝露を示す用語として"long term"、"chronic"、"cohort"を組み合わせて行い、PM_2.5と死亡との関連について検討した24件 （対象地域：アジア3件、ヨーロッパ6件、北米15件） の文献を抽出した。PM_2.5の曝露評価で用いられた方法は、1990年代～2000年代前半までに公表された研究では、固定測定局による観測値を用いることが一般的であった。近年、空間補間、拡散モデル、Land use regressionモデル、化学輸送モデル、衛星観測で得られるエアロゾルの光学的厚さを用いた推定や、上記の組み合わせによるPM_2.5濃度推定値を用いた研究が増えている。各研究の対象地域におけるPM_2.5濃度 （平均値、あるいは中央値） は、8.1～35.3 μg/m³であった。PM_2.5の死亡に対する影響推定値は、多くの研究で正の関連がみられるものの、一部では負の関連もみられ、研究間の異質性が認められた。メタ解析では、PM_2.5の単位濃度(10 μg/m³)あたりのリスク比は1.07 (95％CI: 1.04, 1.09) であった。アジアなどPM_2.5濃度の高い地域での研究はほとんどなく、高濃度におけるPM_2.5の健康影響について不確実性が残る。今後、アジアを含むPM_2.5濃度の高い地域における研究が望まれる。

A register-based study of the association between air pollutants and hypertensive disorders in pregnancy among the Japanese population
Takehiro Michikawa, Seiichi Morokuma, Kotaro Fukushima, Kayo Ueda, Ayano Takeuchi, Kiyoko Kato, Hiroshi Nitta
ENVIRONMENTAL RESEARCH, 142, 644, 650, 2015年10月, ［査読有り］
英語, 研究論文（学術雑誌）

大気環境物質のためのシームレス同化システム構築とその応用 (小特集 文科省「気候変動適応研究推進プログラム」の成果紹介)
中島 映至, 今須 良一, 高見 昭憲, 五藤 大輔, 鶴田 治雄, 打田 純也, Dai Tie, 三澤 翔大, 上田 佳代, Ng Chris Fook Sheng, 渡辺 知保, 小西 祥子, 佐藤 陽祐, 樋口 篤志, 増冨 祐司, 村上 暁信, 土屋 一彬, 近藤 裕昭, 丹羽 洋介, 芳村 圭, 大原 利眞, 森野 悠, Schutgens Nick, 須藤 健悟, 竹村 俊彦, 井上 豊志郎, 新井 豊, 村田 諒, 米元 亮馬, Trieu Tran Thi Ngoc, 植松 光夫, 佐藤 正樹, 富田 浩文, 八代 尚, 原 政之
シミュレーション, 34, 2, 104, 114, 小宮山印刷工業, 2015年06月
日本語, 研究論文（学術雑誌）

The Relationship Between Asian Dust Events and Out-of-Hospital Cardiac Arrests in Japan
Takahiro Nakamura, Masahiro Hashizume, Kayo Ueda, Tatsuhiko Kubo, Atsushi Shimizu, Tomonori Okamura, Yuji Nishiwaki
JOURNAL OF EPIDEMIOLOGY, 25, 4, 289, 296, 2015年04月, ［査読有り］
英語, 研究論文（学術雑誌）

Community trial on heat related-illness prevention behaviors and knowledge for the elderly
Noriko Takahashi, Rieko Nakao, Kayo Ueda, Masaji Ono, Masahide Kondo, Yasushi Honda, Masahiro Hashizume
International Journal of Environmental Research and Public Health, 12, 3, 3188, 3214, MDPI AG, 2015年03月17日, ［査読有り］
英語, 研究論文（学術雑誌）

Coarse particulate matter and emergency ambulance dispatches in Fukuoka, Japan: a time-stratified case-crossover study
Takehiro Michikawa, Kayo Ueda, Ayano Takeuchi, Kenji Tamura, Makoto Kinoshita, Takamichi Ichinose, Hiroshi Nitta
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 20, 2, 130, 136, 2015年03月, ［査読有り］
英語, 研究論文（学術雑誌）

Application of a global nonhydrostatic model with a stretched-grid system to regional aerosol simulations around Japan
D. Goto, T. Dai, M. Satoh, H. Tomita, J. Uchida, S. Misawa, T. Inoue, H. Tsuruta, K. Ueda, C. F. S. Ng, A. Takami, N. Sugimoto, A. Shimizu, T. Ohara, T. Nakajima
GEOSCIENTIFIC MODEL DEVELOPMENT, 8, 2, 235, 259, 2015年, ［査読有り］
英語, 研究論文（学術雑誌）

Impact of short-term exposure to fine particulate matter on emergency ambulance dispatches in Japan
Takehiro Michikawa, Kayo Ueda, Ayano Takeuchi, Makoto Kinoshita, Hiromi Hayashi, Takamichi Ichinose, Hiroshi Nitta
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 69, 1, 86, 91, 2015年01月, ［査読有り］
英語, 研究論文（学術雑誌）

大気汚染と脳梗塞・心血管疾患の発生・増悪 (特集 大気汚染による呼吸器・循環器疾患は増加している)
上田 佳代
日本医事新報, 4766, 30, 35, 日本医事新報社, 2015年01月, ［招待有り］
日本語

Particulate matter modifies the association between airborne pollen and daily medical consultations for pollinosis in Tokyo
Shoko Konishi, Chris Fook Sheng Ng, Andrew Stickley, Shinichi Nishihata, Chisa Shinsugi, Kayo Ueda, Akinori Takami, Chiho Watanabe
SCIENCE OF THE TOTAL ENVIRONMENT, 499, 125, 132, 2014年11月, ［査読有り］
英語, 研究論文（学術雑誌）

Desert Dust Is a Risk Factor for the Incidence of Acute Myocardial Infarction in Western Japan
Ryuichi Matsukawa, Takehiro Michikawa, Kayo Ueda, Hiroshi Nitta, Tomohiro Kawasaki, Hideki Tashiro, Masahiro Mohri, Yusuke Yamamoto
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES, 7, 5, 743, U158, 2014年09月, ［査読有り］
英語, 研究論文（学術雑誌）

Desert dust is a risk factor for the incidence of acute myocardial infarction in Western Japan.
Matsukawa R, Michikawa T, Ueda K, Nitta H, Kawasaki T, Tashiro H, Mohri M, Yamamoto Y
Circulation. Cardiovascular quality and outcomes, 7, 5, 743, 748, 2014年09月, ［査読有り］

Characterizing the effect of summer temperature on heatstroke-related emergency ambulance dispatches in the Kanto area of Japan
Chris Fook Sheng Ng, Kayo Ueda, Masaji Ono, Hiroshi Nitta, Akinori Takami
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY, 58, 5, 941, 948, 2014年07月, ［査読有り］
英語, 研究論文（学術雑誌）

日本の大気環境と健康への影響 (特集 最近の大気汚染とアレルギー疾患) -- (大気環境の変化)
新田 裕史, 上田 佳代
アレルギー・免疫, 21, 10, 1475, 1483, 医薬ジャーナル社, 2014年01月
日本語, 研究論文（学術雑誌）

環境汚染物質とアレルギー
本田 晶子, 上田 佳代, 高野 裕久
日本予防医学会雑誌, 9, 2, 61, 66, 日本予防医学会, 2014年01月, ［査読有り］
日本語, 研究論文（学術雑誌）

黄砂の脳梗塞発症に及ぼす影響に関する研究 (特別号 東アジアにおけるエアロゾルの植物・人間系へのインパクト) -- (エアロゾルの健康影響の解明)
北園 孝成, 上田 佳代, 吾郷 哲朗
エアロゾル研究, 29, 1, 207, 211, 日本エアロゾル学会, 2014年01月, ［招待有り］
日本語, 研究論文（学術雑誌）

Interpretive Article 疫学研究におけるライダーによる黄砂エアロゾルの曝露評価 (特別号 東アジアにおけるエアロゾルの植物・人間系へのインパクト) -- (エアロゾルの健康影響の解明)
上田 佳代, 清水 厚, 井上 健一郎
エアロゾル研究, 29, 1, 230, 236, 日本エアロゾル学会, 2014年01月
日本語, 研究論文（学術雑誌）

C459 大気環境物質のためのシームレス同化システム構築とその応用(都市における気候変動適応研究の最先端,専門分科会)
中島 映至, 今須 良一, 植松 光夫, 高見 昭憲, 五藤 大輔, 打田 純也, 井上 豊志郎, 鶴田 治雄, 三澤 翔大, 村田 諒, Tie Dai, Nick Schutgens, 上田 佳代, Chris-Fook-Sheng Ng, 佐藤 正樹, 佐藤 陽祐, 村上 暁信, 樋口 篤志, SALSAプロジェクトチーム
大会講演予講集, 105, 429, 429, 社団法人日本気象学会, 2014年01月
日本語, 研究論文（学術雑誌）

東アジア・東南アジアの大気汚染による健康影響の評価
本田 靖, 中井 里史, 小野 雅司, 田村 憲治, 新田 裕史, 上田 佳代
エアロゾル研究, 29, 1, s183, s189, 日本エアロゾル学会, 2014年
日本語, In this article, we give an overview of East Asian epidemiological studies, including part P12 of Grant in-Aid for Scientific Research in Innovative Areas: "Impacts of Aerosols in East Asia on Plants and Human Health." In particular, we focus on "health effects of East and Southeast Asian air pollution." The body of research surveyed can be divided into studies on short-term effects and long-term effects.The short-term effect studies can further be divided into studies on local effects and trans-boundary effects. We reviewed research on Japanese cedar pollen diseases and particulate matter for short-term local effects, and Asian dust and particulate matter for trans-boundary effects. For long-term effects, we reviewed critically some research that utilized existing cohort studies.

Sociogeographic Variation in the Effects of Heat and Cold on Daily Mortality in Japan
Chris Fook Sheng Ng, Kayo Ueda, Ayano Takeuchi, Hiroshi Nitta, Shoko Konishi, Rinako Bagrowicz, Chiho Watanabe, Akinori Takami
JOURNAL OF EPIDEMIOLOGY, 24, 1, 15, 24, 2014年01月, ［査読有り］
英語, 研究論文（学術雑誌）

Seasonal variation in the acute effects of ozone on premature mortality among elderly Japanese
Chris Fook Sheng Ng, Kayo Ueda, Hiroshi Nitta, Ayano Takeuchi
ENVIRONMENTAL MONITORING AND ASSESSMENT, 185, 10, 8767, 8776, 2013年10月, ［査読有り］
英語, 研究論文（学術雑誌）

2012 年夏季，福岡市と大阪市における高濃度硫酸イオン観測事例の解析
高見 昭憲, 伊礼 聡, 紀本 岳志, 竹村 俊彦, 林 政彦, 原 圭一郎, 三好 猛雄, 上田 佳代, 佐藤 圭, 兼保 直樹, 吉野 彩子, 畠山 史郎
エアロゾル研究, 28, 4, 281, 286, 日本エアロゾル学会, 2013年01月, ［査読有り］
日本語, 研究論文（学術雑誌）, We observed high sulfate ion concentrations in Fukuoka and Osaka city using an aerosol mass spectrometer and an ion chromatograph method in the end of July, 2012. The mass concentration of sulfate ion reached ca. 35 μg m^-3 on 25 July in Fukuoka. The mass concentration of PM_2.5 exceeded 50 μg m^-3 and that of sulfate ion was between 10and 20 μg m^-3 for several hours on 29 July in Osaka. The simulation using Spectral Radiation- Transport Model for Aerosol Species (SPRINTARS) showed that the air mass with a high sulfate ion concentration first covered the Korean peninsula in July 2012 and then spread over the northern part of Kyushu and the Honshu regions of Japan. This indicates that the observed high sulfate ion events were possibly due to the trans-boundary air pollution. Since air pollution with a high sulfate ion concentration potentially causes adverse health effect, the monitoring of trans-boundary air pollution is necessary even in summer.

S13-4 黄砂が喘息,アレルギー疾患に及ぼす影響評価 : 疫学研究における曝露評価をどのように行うか(黄砂の健康への影響,シンポジウム13,第63回日本アレルギー学会秋季学術大会)
上田 佳代, 小田嶋 博, 井上 健一郎, 清水 厚, 新田 裕史
アレルギー, 62, 9, 1204, 1204, 一般社団法人日本アレルギー学会, 2013年01月
日本語, 研究論文（学術雑誌）

循環器疾患に対する粒子状物質の長期曝露影響 (AYUMI PM2.5と健康 : 大気汚染Update)
上田 佳代
医学のあゆみ, 247, 8, 678, 683, 医歯薬出版, 2013年01月
日本語

Long-range transported Asian Dust and emergency ambulance dispatches
Kayo Ueda, Atsushi Shimizu, Hiroshi Nitta, Kenichiro Inoue
INHALATION TOXICOLOGY, 24, 12, 858, 867, 2012年10月, ［査読有り］, ［筆頭著者, 責任著者］
英語, 研究論文（学術雑誌）

微小粒子状物質成分が死亡に及ぼす影響 検出下限未満の実測値処理による推定値の違い
上田 佳代, 山神 真紀子, 池盛 文数, 久恒 邦裕, 新田 裕史
日本衛生学雑誌, 67, 2, 284, 284, (一社)日本衛生学会, 2012年02月, ［査読有り］
日本語

光化学オキシダントの健康影響-20都市研究の結果と海外の知見
上田 佳代, Ng Chris Fook Sheng, 新田 裕史
大気環境学会誌, 47, 1, A9, A11, Japan Society for Atmospheric Environment, 2012年01月
日本語, 研究論文（学術雑誌）

Exposure to Particulate Matter and Long-term Risk of Cardiovascular Mortality in Japan: NIPPON DATA80
Kayo Ueda, Shin-ya Nagasawa, Hiroshi Nitta, Katsuyuki Miura, Hirotsugu Ueshima
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 19, 3, 246, 254, 2012年, ［査読有り］, ［筆頭著者, 責任著者］
英語, 研究論文（学術雑誌）

Short-Term Exposure to Air Pollution and Incidence of Stroke and Acute Myocardial Infarction in a Japanese Population
Tanvir Chowdhury Turin, Yoshikuni Kita, Nahid Rumana, Yasuyuki Nakamura, Kayo Ueda, Naoyuki Takashima, Hideki Sugihara, Yutaka Morita, Masaharu Ichikawa, Kunihiko Hirose, Hiroshi Nitta, Akira Okayama, Katsuyuki Miura, Hirotsugu Ueshima
NEUROEPIDEMIOLOGY, 38, 2, 84, 92, 2012年, ［査読有り］
英語, 研究論文（学術雑誌）

Ambient Air Pollutants and Acute Case-Fatality of Cerebro-Cardiovascular Events: Takashima Stroke and AMI Registry, Japan (1988-2004)
Tanvir Chowdhury Turin, Yoshikuni Kita, Nahid Rumana, Yasuyuki Nakamura, Kayo Ueda, Naoyuki Takashima, Hideki Sugihara, Yutaka Morita, Masaharu Ichikawa, Kunihiko Hirose, Hiroshi Nitta, Akira Okayama, Katsuyuki Miura, Hirotsugu Ueshima
CEREBROVASCULAR DISEASES, 34, 2, 130, 139, 2012年, ［査読有り］
英語, 研究論文（学術雑誌）

PM2.5各成分が死亡に及ぼす影響評価　　　　　　　　　　　　　　　
上田 佳代, 山神 真紀子, 池盛 文数, 久恒 邦裕, 新田 裕史
大気環境学会年会講演要旨集, 52回, 298, 298, (公社)大気環境学会, 2011年08月, ［査読有り］
日本語

PM_<2.5>-第4講 微小粒子状物質の健康影響 : 疫学研究の動向と日本における疫学知見
上田 佳代
大気環境学会誌 = Journal of Japan Society for Atmospheric Environment, 46, 2, A7, A13, 公益社団法人 大気環境学会, 2011年03月20日
日本語

Effects of Asian Dust Events on Daily Mortality in Nagasaki, Japan
Masahiro Hashizume, Yuji Nishiwaki, Takehiro Michikawa, Kayo Ueda, Daisuke Onozuka, Ken-ichi Yokota, Mariko Mine, Atsuko Mori, Atsushi Shimizu, Nobuo Sugimoto, Taro Yamamoto
EPIDEMIOLOGY, 22, 1, S130, S130, 2011年01月, ［査読有り］
英語

Health effects of Asian dust events: a review of the literature.
Hashizume M, Ueda K, Nishiwaki Y, Michikawa T, Onozuka D
Nippon eiseigaku zasshi. Japanese journal of hygiene, 65, 3, 413, 421, 2010年05月, ［査読有り］, ［国内誌］
日本語, 研究論文（学術雑誌）

Estimating Mortality Effects of Fine Particulate Matter in Japan: A Comparison of Time-Series and Case-Crossover Analyses
Kayo Ueda, Hiroshi Nitta, Masaji Ono, Ayano Takeuchi
JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION, 59, 10, 1212, 1218, 2009年10月, ［査読有り］, ［筆頭著者, 責任著者］
英語, 研究論文（学術雑誌）

Effects of Fine Particulate Matter on Daily Mortality for Specific Heart Diseases in Japan
Kayo Ueda, Hiroshi Nitta, Masaji Ono
CIRCULATION JOURNAL, 73, 7, 1248, 1254, 2009年07月, ［査読有り］, ［筆頭著者, 責任著者］
英語, 研究論文（学術雑誌）

気候危機とその健康リスクにどう立ち向かう?-熱中症や気候変動関連の健康被害を防ぐために-
上田佳代, 橋爪真弘, 山田朋人, 南齋規介, 的場光太郎, 新井明日奈, 北海道医学雑誌, 100, 1, 2025年

特集 気候変動と医療 気候変動により変化する大気汚染の健康影響
上田 佳代, 医学のあゆみ, 290, 3, 228, 231, 2024年07月20日
医歯薬出版

新興国における国際共同疫学研究の課題-インドにおける学際研究から-
上田佳代, 日本疫学会学術総会講演集(Web), 34th, 2024年

インドのパンジャブ州における医療事情に関する調査
梅村朋弘, 大西一成, 寺崎寛章, 中山智喜, 松見豊, 鈴木孝太, 上田佳代, 日本衛生学雑誌(Web), 79, Supplement, 2024年

北海道の職域における暑熱曝露と救急搬送との関連
上田佳代, XERXES Seposo, 新井明日奈, ATHICHA Uttajug, BASIT Ahamad Tajudin Muhammad Abdul, 日本産業衛生学会北海道地方会プログラム・抄録, 2024, 2024年

介護施設における熱中症への準備状況とその関連因子に関する探索的検討
新井明日奈, 高橋恭子, 上田佳代, 日本公衆衛生学会総会抄録集(CD-ROM), 83rd, 2024年

微小粒子状物質成分の短期曝露と救急搬送との関連性について
道川武紘, 道川武紘, 山崎新, 高見昭憲, 上田佳代, 西脇祐司, 日本公衆衛生学会総会抄録集(CD-ROM), 83rd, 2024年

インド・パンジャブ州の医療事情に関する調査
梅村朋弘, 大西一成, 寺崎寛章, 中山智喜, 松見豊, 鈴木孝太, 上田佳代, グローバルヘルス合同大会プログラム・抄録集, 2024 (CD-ROM), 2024年

北海道十勝地域の精神科医療の現状と精神保健福祉対策の課題
岡崎奈穂美, 岡崎奈穂美, 吉田祐子, 石谷絵里, 森昭久, 新井明日奈, 上田佳代, 日本公衆衛生学会総会抄録集(CD-ROM), 83rd, 2024年

低濃度のPM2.5への曝露と急性疾患発生との関係
上田佳代, セポソ サークセス, アタッチャ アティーシャ, アハマッドタジュヂン バシットムハマッドアブドゥル, ウンクリス フックシェン, 橋爪真弘, 岡和孝, 日本疫学会学術総会講演集(Web), 34th, 2024年

PM2.5・超微小粒子の健康影響—Health effects of PM2.5 and ultrafine particles—特集 環境化学物質が人体へ与える影響
上田 佳代, 医学のあゆみ, 285, 2, 113, 117, 2023年04月08日
東京 : 医歯薬出版, 日本語

超微小粒子の健康影響に関する疫学知見
上田佳代, 池田和男, PAOIN Kanawat, LIANG Yuwen, エアロゾル研究, 38, 1, 2023年

PM2.5成分データを用いた大気中シリカ濃度と特発性間質性肺炎の因果関係の検討
古賀康彦, 熊谷貴美代, 木田節, 西岡典宏, 久田剛志, 土橋邦生, 上田佳代, 石見拓, 日本衛生学雑誌(Web), 78, Supplement, 2023年

大気オゾンの環境影響評価に向けたバイアス補正手法の検討
木村知里, 森野悠, 永島達也, 荒木真, 上田佳代, 米倉哲志, 大気環境学会誌(Web), 58, 3, 2023年

東京における自動測定されたPM_2.5成分濃度と死亡との関連性について
道川武紘, 道川武紘, 山崎新, 高見昭憲, 菅田誠治, 藤谷雄二, 吉野彩子, 上田佳代, 武田悠希, 西脇祐司, 日本衛生学雑誌(Web), 78, Supplement, 2023年

院外心停止患者のEMS response timeに対する積雪の影響:北海道・東京における検討
上瀧浩邦, SEPOSO Xerxes Tesoro, UTTAJUG Athicha, 新井明日奈, 横田勲, 安斉俊久, 上田佳代, 日本疫学会学術総会講演集(Web), 33rd, 2023年

粗大粒子状物質の短期曝露と死亡との関連性について
道川武紘, 道川武紘, 山崎新, 高見昭憲, 菅田誠治, 藤谷雄二, 吉野彩子, 上田佳代, 西脇祐司, 日本疫学会学術総会講演集(Web), 33rd, 2023年

航空機由来超微小粒子に関連する健康リスクの推定
上田佳代, XERXES Seposo, 伏見暁洋, 藤谷雄二, 竹川暢之, 大気環境学会年会講演要旨集, 63rd, 2022年

ケースクロスオーバーデザインによる微小粒子成分と23区内救急搬送との関連性について
道川武紘, 道川武紘, 佐々木淳一, 山崎新, 高見昭憲, 朝倉敬子, 今村晴彦, 上田佳代, 齊藤伸治, 星純也, 吉野彩子, 菅田誠治, 新田裕史, 西脇祐司, 日本疫学会学術総会講演集(Web), 32nd, 2022年

全世界を対象とした異なるPM_2.5由来の健康影響評価関数に関する研究
関沢賢, 渡邉諒一, 藤森真一郎, 大城賢, 上田佳代, 土木学会論文集 G(環境)(Web), 78, 5, 2022年

Developing a risk function of PM2.5 and Under 5 Child Mortality: A Review.
Wahida Musarrat Anita, Ueda Kayo, 日本公衆衛生雑誌 第80回日本公衆衛生学会総会, 68, 11, 311, 311, 2021年12月
32891745

Health risk perception and Awareness of air pollu- tion: Scoping review
Bahrami Zeinab, Yang Zhesi, Onishi Kazunari, Umemura Tomohiro, Ueda Kayo, 日本公衆衛生雑誌 第80回日本公衆衛生学会総会, 68, 11, 311, 2021年12月
36683955

Face mask use under the COVID-19 pandemic for farmers in Punjab, India
Yang Zhesi, Ueda Kayo, memura Tomohiro, Onishi Kazunari, 日本公衆衛生雑誌 第80回日本公衆衛生学会総会, 68, 11, 196, 2021年12月
36683955

City-specific modifiers of acute PM2.5 and ozone ef- fects on ambulance dispatches　　　　　　　　　　　　　　　
梁雨文, 上田佳代, 橋爪真弘, 日本公衆衛生雑誌 第80回日本公衆衛生学会総会, 68, 11, 195, 2021年12月

大気汚染物質による暑熱関連死亡への修飾効果
久保龍征, 上田佳代, 橋爪真弘, 日本公衆衛生雑誌 第80回日本公衆衛生学会総会抄録集, 68, 11, 290, 2021年12月
32891745

超微小粒子の健康影響に関する文献レビュー
上田佳代, 池田一男, Paoin Kanawat, 梁雨文, 竹川暢之, 伏見暁洋, 藤谷雄二, 桜井博, 村島淑子, 第62回大気環境学会年会講演要旨集, 217, 2021年09月, ［筆頭著者］
36684140

Public perception of air pollution and stubble burning—a cross-sectional survey study in Punjab, India
Yang Zhesi, 上田佳代, 梅村朋弘, 大西一成, 寺崎寛章, 松見豊, 中山智喜, 村尾 るみこ, 浅田晴久, 佐藤孝宏, 林田佐智子, 第62回大気環境学会年会講演要旨集, 184, 2021年09月
36683955

日本における感染性胃腸炎の発生と降雨量との関係
山下 慧, 高野 裕久, 上田 佳代, 本田 昌子, 田中 宏明, 日高 平, ザーゼス・セポ, 日本衛生学雑誌, 76, Suppl., S157, S157, 2021年03月
(一社)日本衛生学会, 日本語

Association between PM[2.5] and Heart rate variability in 3 cities of Japan (京都大学環境衛生工学研究会 第41回 シンポジウム講演論文集)
PAOIN Kanawat, UEDA Kayo, SEPOSO Xerxes Tesoro, HAYANO Junichiro, KIYONO Ken, UEDA Norihiro, KAWAMURA Takashi, TAKANO Hirohisa, 環境衛生工学研究 = Environmental & sanitary engineering research : 京都大学環境衛生工学研究会機関誌, 33, 3, 118, 120, 2019年07月
京都大学環境衛生工学研究会, 英語, 速報，短報，研究ノート等（大学，研究機関紀要）

日本の21都市におけるオゾンと外来患者の非線形な関連
セポソ サークセス, セポソ サークセス, 上田佳代, 上田佳代, 吉野彩子, 菅田誠治, 高見昭憲, 日本衛生学雑誌(Web), 74, Supplement, S118, 2019年02月
英語, 速報，短報，研究ノート等（学術雑誌）

学術研究からの少子化対策 日本衛生学会からの提言に向けて 日本衛生学会における少子化対策提言に向けて 日本衛生学会少子化対策ワーキンググループによるとりまとめ　　　　　　　　　　　　　　　
野村 恭子, 苅田 香苗, 荒木 敦子, 西岡 笑子, 武藤 剛, 岩井 美幸, 錦谷 まりこ, 井上 まり子, 鶴ヶ野 しのぶ, 北野 尚美, 辻 真弓, 飯島 佐知子, 上田 佳代, 上島 通浩, 山縣 然太郎, 坂田 清美, 伊木 雅之, 柳澤 裕之, 加藤 昌志, 横山 和仁, 小泉 昭夫, 大槻 剛巳, 日本衛生学雑誌, 74, 1of5, 5of5, 2019年
日本衛生学会では、少子化対策ワーキンググループを設置し、少子化対策シンポジウムを開催し、この問題について様々な角度から議論を重ねてきた。主にそのシンポジウムにおける学術的知見を次の様にまとめた。1)未婚化、晩婚化に対する社会環境整備、2)労働衛生領域における環境整備、3)職場の少子化対策、4)環境化学物質による性成熟、生殖能力への影響、5)社会環境および親のストレスと小児の健全な育ちに関する包括的な研究、として述べた。, (一社)日本衛生学会, 日本語

学術研究からの少子化対策 日本衛生学会からの提言に向けて 日本衛生学会における少子化対策提言に向けて 日本衛生学会少子化対策ワーキンググループによるとりまとめ　　　　　　　　　　　　　　　
野村 恭子, 苅田 香苗, 荒木 敦子, 西岡 笑子, 武藤 剛, 岩井 美幸, 錦谷 まりこ, 井上 まり子, 鶴ヶ野 しのぶ, 北野 尚美, 辻 真弓, 飯島 佐知子, 上田 佳代, 上島 通浩, 山縣 然太郎, 坂田 清美, 伊木 雅之, 柳澤 裕之, 加藤 昌志, 横山 和仁, 小泉 昭夫, 大槻 剛巳, 日本衛生学雑誌, 74, 1of5, 5of5, 2019年
日本衛生学会では、少子化対策ワーキンググループを設置し、少子化対策シンポジウムを開催し、この問題について様々な角度から議論を重ねてきた。主にそのシンポジウムにおける学術的知見を次の様にまとめた。1)未婚化、晩婚化に対する社会環境整備、2)労働衛生領域における環境整備、3)職場の少子化対策、4)環境化学物質による性成熟、生殖能力への影響、5)社会環境および親のストレスと小児の健全な育ちに関する包括的な研究、として述べた。, (一社)日本衛生学会, 日本語

黄砂の健康影響に関する疫学文献レビュー：2009年－2018年
蓮沼 英樹, 渡部 仁成, 橋爪 真弘, 市瀬 孝道, 上田 佳代, 小田嶋 博, 金谷 久美子, 清水 厚, 高見 昭憲, 竹内 文乃, 西脇 祐司, 日本衛生学雑誌, 74, 0, n/a, 2019年, ［国内誌］

Asian dust is a phenomenon involving the long-range transport of atmospheric pollutants originating from the desert areas of China and Mongolia. In recent years, the health effects of Asian dust have raised public concerns. Numerous studies on the health effects of Asian dust have been published since the last review in 2010. Thus, a literature review was conducted to shed light on the latest epidemiologic findings. PubMed and Science Direct databases were used for the review of epidemiologic studies published between June 2009 and April 2018. We identified 53 epidemiologic studies. Mortality, ambulance transportation, hospitalization/medical examination, changes in symptomatic, functional, and examination findings, as well as birth outcomes have been reported as outcomes. When the outcomes were categorized by disease, the effects of Asian dust on respiratory, cardiovascular, and allergic diseases raised concerns. The common evidences of causation between Asian dust and these diseases were the consistency of findings and temporal sequence of association. As results of research on dose-response relationships have become available, and the possibility that the health effects of Asian dust may vary depending on its chemical composition has been pointed out, further research using the exposure level indicators of Asian dust or its chemical composition should be conducted. Furthermore, with focus on the crucial issue of reducing exposure, research related to prevention and raising awareness should be further promoted.

, 一般社団法人日本衛生学会, 日本語

黄砂の健康影響に関する疫学文献レビュー 2009年-2018年
蓮沼 英樹, 市瀬 孝道, 上田 佳代, 小田嶋 博, 金谷 久美子, 清水 厚, 高見 昭憲, 竹内 文乃, 西脇 祐司, 渡部 仁成, 橋爪 真弘, 日本衛生学雑誌, 74, 1 of 16, 16 of 16, 2019年, ［国内誌］
Asian dust is a phenomenon involving the long-range transport of atmospheric pollutants originating from the desert areas of China and Mongolia. In recent years, the health effects of Asian dust have raised public concerns. Numerous studies on the health effects of Asian dust have been published since the last review in 2010. Thus, a literature review was conducted to shed light on the latest epidemiologic findings. PubMed and Science Direct databases were used for the review of epidemiologic studies published between June 2009 and April 2018. We identified 53 epidemiologic studies. Mortality, ambulance transportation, hospitalization/medical examination, changes in symptomatic, functional, and examination findings, as well as birth outcomes have been reported as outcomes. When the outcomes were categorized by disease, the effects of Asian dust on respiratory, cardiovascular, and allergic diseases raised concerns. The common evidences of causation between Asian dust and these diseases were the consistency of findings and temporal sequence of association. As results of research on dose-response relationships have become available, and the possibility that the health effects of Asian dust may vary depending on its chemical composition has been pointed out, further research using the exposure level indicators of Asian dust or its chemical composition should be conducted. Furthermore, with focus on the crucial issue of reducing exposure, research related to prevention and raising awareness should be further promoted., (一社)日本衛生学会, 日本語

大気中SPMの経時変化と救急車出動との関連性(Hourly variation in ambient SPM and its association with emergency ambulance dispatches)　　　　　　　　　　　　　　　
Phung Vera Ling Hui, 上田 佳代, Seposo Xerxes, 道川 武紘, 山崎 新, 新田 裕史, 高見 昭憲, 菅田 誠治, 吉野 彩子, 本田 晶子, 高野 裕久, 大気環境学会年会講演要旨集, 59回, 292, 292, 2018年08月
(公社)大気環境学会, 英語, 速報，短報，研究ノート等（学術雑誌）

Impact of Global Change in Sulfur Dioxide, Black Carbon and Organic Carbon on PM2.5-Related Premature Mortality and Years Life Lost　　　　　　　　　　　　　　　
Seposo, XT, 上田佳代, Park, SS, 須藤 健悟, 竹村 俊彦, 中島 映至, Environmental Health Perspective, 2018年08月
英語, 速報，短報，研究ノート等（学術雑誌）

PM2.5の健康影響―身近な疑問から最新の研究結果まで―
上田佳代, XERXES Seposo, 大気環境学会年会講演要旨集, 59th, 204‐205, 2018年08月
日本語, 速報，短報，研究ノート等（学術雑誌）

Effects of ambient PM_2.5 and ozone on outpatient asthma visits in 21 Japanese Cities
SEPOSO Xerxes, SEPOSO Xerxes, UEDA Kayo, UEDA Kayo, SUGATA Seiji, YOSHINO Ayako, TAKAMI Akinori, 大気環境学会年会講演要旨集, 59th, 359, 2018年08月
英語, 速報，短報，研究ノート等（学術雑誌）

Effect of streamer plasma irradiation on ambient PM2.5-induced pro-inflammatory responses in human bronchial epithelial cells.　　　　　　　　　　　　　　　
Tanaka T, Tamura S, Honda A, Tanaka M, Okano H, Onishi T, Takai S, Wang Z, Ueda K, Takano H, IndoorAir2018, 2018年07月
英語, 研究発表ペーパー・要旨（国際会議）

Health effect of air pollution in Thailand: Recent research development and challenges.　　　　　　　　　　　　　　　
Phosri A, Ueda, K, Honda A, Takano H, ISEE-AC, 2018年06月
英語, 研究発表ペーパー・要旨（国際会議）

埼玉県における大量の降雨が感染性胃腸炎の発生件数に与える影響
金藤一路, 上田佳代, 小谷和也, セポソ サークセス, 本田晶子, 高野裕久, 日本衛生学雑誌(Web), 73, Supplement, S227, 2018年03月
日本語, 速報，短報，研究ノート等（学術雑誌）

長崎での黄砂が小児気管支喘息患者へ及ぼす影響　　　　　　　　　　　　　　　
中村 孝裕, 西脇 祐司, 森内 浩幸, 上田 佳代, 清水 厚, 竹内 文乃, 橋爪 真弘, 日本衛生学雑誌, 73, Suppl., S268, S268, 2018年03月
(一社)日本衛生学会, 日本語

長崎での黄砂が小児気管支喘息患者へ及ぼす影響
中村 孝裕, 西脇 祐司, 森内 浩幸, 上田 佳代, 清水 厚, 竹内 文乃, 橋爪 真弘, 日本衛生学雑誌, 73, Suppl., S268, S268, 2018年03月
(一社)日本衛生学会, 日本語

長崎での黄砂が小児気管支喘息患者へ及ぼす影響
中村孝裕, 西脇祐司, 森内浩幸, 上田佳代, 清水厚, 竹内文乃, 橋爪真弘, 日本衛生学雑誌(Web), 73, Supplement, S268, 2018年03月
日本語

夏季の高気温が救急搬送数に与える影響：年齢別の検討　　　　　　　　　　　　　　　
小谷和也, 上田佳代, サークセス セポソ, 安河内秀輔, 松本弘子, 小野雅司, 本田晶子, 高野裕久, 第88回日本衛生学会学術総会, 2018年03月
日本語

光化学オキシダントと急病による救急搬送との関連：複数都市における疾患別検討　　　　　　　　　　　　　　　
長谷川博史, 上田佳代, 本田晶子, 高野裕久, 第88回日本衛生学会学術総会, 2018年03月
日本語

埼玉における極端な降雨が感染性胃腸炎の発生件数に与える影響　　　　　　　　　　　　　　　
金藤一路, 上田佳代, 小谷和也, Seposo Xerxes Tesoro, 本田晶子, 高野裕久, 第88回日本衛生学会学術総会, 2018年03月
日本語

Effects of ambient PM2.5 collected from Asian cities using cyclone technique on human airway epithelial cells　　　　　　　　　　　　　　　
Chowdhury,P H, Honda,A, Ito,S, Okano,H, Onishi,T, Higashihara,M, Tanaka, T, Hirai,S, Ueda,K, Takano,H, 第58回大気環境学会年会, 2017年09月
英語

福岡におけるPM2.5の化学成分と小学生の症状との関連　　　　　　　　　　　　　　　
杉山太一, 上田佳代, 中島亜矢子, 木下誠, 小川貴史, 藤本正典, 道川武紘, 新田裕史, 第58回大気環境学会年会, 2017年09月
日本語

Short-term exposure to air pollution and daily hospital admissions for acute myocardial infarction in Bangkok, Thailand　　　　　　　　　　　　　　　
Phosri A, Ueda K, Phung V.L.H, Yasukouchi S, Sugiyama T, Paoin K, Kotani K, Hasegawa H, Honda A, Takano H, Conference of ISEE 2017, 2017年09月
英語, 研究発表ペーパー・要旨（国際会議）

Association between short-term exposure to ambient ozone and PM2.5 and health effects among Japanese adults in different regions in Japan.　　　　　　　　　　　　　　　
Phung V.L.H, Ueda K, Phosri A, Hasegawa H, Sugiyama T, Paoin K, Seposo X T, Honda A, Takano H, Conference of ISEE 2017, 2017年09月
英語, 研究発表ペーパー・要旨（国際会議）

Determining the concentration‐response risk function of daily PM_2.5 concentration on daily all‐cause mortality from the 9 cities in Japan: An application of penalized Distribute Lag Non‐Linear Model
SEPOSO Xerxes, MICHIKAWA Takehiro, NITTA Hiroshi, YAMAZAKI Shin, UEDA Kayo, 大気環境学会年会講演要旨集, 58th, 240, 2017年08月
英語, 速報，短報，研究ノート等（学術雑誌）

トリクロロエチレン健康リスク評価作業部会報告書 トリクロロエチレンに係る健康リスク評価について
青木 康展, 上田 佳代, 内山 巌雄, 上島 通浩, 祖父江 友孝, 武林 亨, 中杉 修身, 那須 民江, 新田 裕史, 野見山 哲生, 山崎 新, 朝倉 敬子, 苅田 香苗, 塚原 照臣, 中野 真規子, 道川 武紘, 安達 修一, 高野 裕久, 中島 宏, トリクロロエチレン健康リスク評価作業部会, 大気環境学会誌, 52, 2, A24, A57, 2017年03月
(公社)大気環境学会, 日本語

福岡におけるPM2.5の化学成分濃度と小学生の有症率との関連　　　　　　　　　　　　　　　
杉山太一, 上田佳代, 中島亜矢子, 木下誠, 小川貴史, 藤本正典, 道川武紘, 新田裕史, 本田晶子, 高野裕久, 第87回日本衛生学会学術年会, 2017年03月
日本語

気温の救急搬送数に対する影響は年齢により異なる　　　　　　　　　　　　　　　
小谷和也, 上田佳代, 安河内秀輔, 本田晶子, 高野裕久, 第87回日本衛生学会学術年会, 2017年03月
日本語

大阪市における光化学オキシダントと救急搬送との関連　　　　　　　　　　　　　　　
長谷川博史, 上田佳代, 本田晶子, 高野裕久, 第87回日本衛生学会学術年会, 2017年03月
日本語

大気エアロゾル中の水溶性成分濃度と急病による救急搬送数との関連　　　　　　　　　　　　　　　
上原大和, 上田佳代, 林政彦, 原圭一郎, Saira Tasmin, 大石瑞貴, Arthit Phosri、Vera Phung Ling Hui, 安河内秀輔, 本田晶子, 高野裕久, 第57回大気環境学会年会, 2016年09月
日本語

暑熱環境下での体感温度と急病による救急搬送数の相関　　　　　　　　　　　　　　　
安河内秀輔, 上田佳代, Tasmin Saira, 大石瑞貴, Arthit Phosri, Phung Vera Ling Hui, 上原大和, 本田晶子, 高野裕久, 第57回大気環境学会年会, 2016年09月
日本語

Association between PM2.5 and hospitalization due to asthma for children and adolescent: exploring susceptibility factors　　　　　　　　　　　　　　　
Ueda,K, Oishi,M, Odashima,H, Tasmin,S, Phung,V.L.H, Yasukouchi,S, Uehara,Y, Honda,A, Takano,H, 第26回国際喘息学会日本・北アジア部会, 2016年09月
英語, 研究発表ペーパー・要旨（国際会議）

Effects of Benzo(a)pyrene, 9,10-phenanthraquinone and 1,2-napthoquinone on respiratory and immune responses.
Chowdhury,PH, Kitamura,G, Honda,A, Sawahara,T, Hayashi,T, Fukushima,W, Kudou,H, Ito,S, Ueda,K, Takano,H, 第38回 京都大学環境衛生工学研究会シンポジウムプログラム, 30, 3, 180, 183, 2016年07月
京都大学環境衛生工学研究会, 英語

Short-term exposure to ambient fine particulate matter (PM2.5) on emergency ambulance dispatches due to acute illnesses in Japan: A multi-city study　　　　　　　　　　　　　　　
Phung,V.L.H, Ueda,K, Tasmin,S, Ooishi,M, Yasukouchi,S, Uehara,Y, Phosri,A, Honda,A, Takano,H, Conference of ISEE-ISES AC2016, 2016年06月
英語, 研究発表ペーパー・要旨（国際会議）

Specific fine particulate matter compositions enhanced the association between airborne pollen and daily consultations for pollinosis in Fukuoka, Japan　　　　　　　　　　　　　　　
Phosri,A, Ueda,K, Tasmin,S, Ooishi,M, Phung,V.L.H, Yasukouchi,S, Uehara,Y, Honda,A, Takano,H, Conference of ISEE-ISES AC2016, 2016年06月
英語, 研究発表ペーパー・要旨（国際会議）

黄砂が小児気管支喘息患者へ及ぼす影響に関する研究(第一報 研究デザイン)
中村孝裕, 西脇祐司, 橋本邦生, 森内浩幸, 北島翼, 小森一広, 田代香澄, 上田佳代, 清水厚, 竹内文乃, 久保達彦, 小田嶋博, 橋爪真弘, Journal of Epidemiology (Web), 26, Supplement 1, 141, 2016年01月21日
日本語

黄砂が小児気管支喘息患者へ及ぼす影響に関する研究(第一報 研究デザイン)
中村孝裕, 西脇祐司, 橋本邦生, 森内浩幸, 北島翼, 小森一広, 田代香澄, 上田佳代, 清水厚, 竹内文乃, 久保達彦, 小田嶋博, 橋爪真弘, Journal of Epidemiology (Web), 26, Supplement 1, 2016年

Health effects of long-term exposure to PM2.5 and mortality: a systematic review　　　　　　　　　　　　　　　
Ueda,K, Tasmin,S, Oishi,M, Phung,V.L.H, Yasukochi,S, Uehara,Y, Honda,A, Takano,H, 第26回日本疫学会学術総会, 2016年01月

Seasonal modification in the effects of acute exposure to outdoor particulate matter on emergency ambulance dispatch due to acute illness in Japan　　　　　　　　　　　　　　　
Tasmin,S, Ueda,K, Phung,V.L.H, Ooishi,M, Yasukouchi,S, Honda,A, Takano,H, Third International Conference on Global Public Health 2015, 2015年12月
英語, 研究発表ペーパー・要旨（国際会議）

九州北部におけるPM2.5の化学成分別分析
三澤健太郎, 吉野彩子, 高見昭憲, 小島知子, 村野健太郎, 畠山史郎, 坂本哲夫, 上田佳代, 道川武紘, 新田裕史, 大気環境学会年会講演要旨集, 56th, 154, 155, 2015年09月04日
日本語

PM2.5の短期曝露と急病による救急搬送との関連 複数都市における検討　　　　　　　　　　　　　　　
上田 佳代, 笠岡 俊志, Tasmin Saira, 道川 武紘, 新田 裕史, 吉野 彩子, 三澤 健太郎, 高見 昭憲, 大気環境学会年会講演要旨集, 56回, 462, 462, 2015年09月
(公社)大気環境学会, 日本語

食品成分がDEPによる気道炎症に及ぼす影響の評価　　　　　　　　　　　　　　　
伊藤翔, 澤原隆紘, 林智裕, 福嶋渉, 北村岳, 工藤仁美, 本田晶子, 上田佳代, 高野裕久, 第22回日本免疫毒性学会, 2015年09月
日本語

黄砂に付着する生物的・化学的成分が呼吸器・免疫系に及ぼす影響
本田晶子, 澤原隆紘, 林智裕, 辻堅志, 福嶋渉, 大石瑞貴, 北村岳, 工藤仁美, 伊藤翔, 吉田成一, 市瀬孝道, 上田佳代, 高野裕久, 第22回日本免疫毒性学会, 22nd, 2015年09月
日本語

福岡におけるPM2.5濃度と小児の喘息による入院との関連　　　　　　　　　　　　　　　
大石瑞貴, 上田佳代, 小田嶋博, Tasmin Saira, Phung Vera Ling Hui, 安河内秀輔, 上原大和, 本田晶子, 高野裕久, 第56回大気環境学会, 2015年09月
日本語

Acute Illnesses due to the Lagged Effects of Ambient Particulate Matter.
Phung,V.L.H, Ueda,K, Tasmin,S, Ooishi,M, Yasukouchi,S, Uehara,Y, Honda,A, Takano,H, 37th Symposium of The Association of Environmental & Sanitary Engineering Research, 29, 3, 31, 34, 2015年07月
京都大学環境衛生工学研究会, 英語

Emergency Ambulance Dispatches due to Acute Illness and Ambient Particulate Matter　　　　　　　　　　　　　　　
上田佳代, 9th Asian Aerosol Conference, 2015年06月
英語, 研究発表ペーパー・要旨（国際会議）

The association between particulate matter components and daily mortality in Nagoya　　　　　　　　　　　　　　　
Kayo Ueda, Makiko Yamagami, Fumikazu Ikemori, Kunihiro Hisatsune, Hiroshi Nitta, 第25回日本疫学会学術総会講演集, 25, Sup1, 88, 2015年01月, ［査読有り］
英語, 研究発表ペーパー・要旨（全国大会，その他学術会議）

Asian Dust Has an impact on the Incidence of Acute Myocardial Infarction similar to a Time-stratified Case-crossover Study
Sunao Kojima, Kunihiko Matsui, Kayo Ueda, Hiroshi Nitta, Hisao Ogawa, CIRCULATION, 130, 2014年11月
英語, 研究発表ペーパー・要旨（国際会議）

気温が急病による救急搬送数に及ぼす影響：6都市における検討　　　　　　　　　　　　　　　
上田佳代, 道川武紘, 新田裕史, 第73回日本公衆衛生学会総会抄録集, 61, 10, 608, 2014年11月
日本語, 研究発表ペーパー・要旨（全国大会，その他学術会議）

PM2.5成分が呼吸器系・免疫細胞に及ぼす影響の検討　　　　　　　　　　　　　　　
福嶋渉, 大石瑞貴, 本田晶子, 辻堅志, 澤原隆紘, 林智裕, 工藤仁美, 上田佳代, 高野裕久, 第21回日本免疫毒性学会学術年会, 2014年09月
日本語

微小粒子状物質(PM2.5)が死亡に及ぼす影響の季節変動　　　　　　　　　　　　　　　
上田佳代, 第55回大気環境学会年会講演要旨集, 351, 2014年09月
日本語

PM2.5成分が免疫担当細胞に及ぼす影響　　　　　　　　　　　　　　　
本田晶子, 辻堅志, 大石瑞貴, 工藤仁美, 澤原隆紘, 林智裕, 福嶋渉, 上田佳代, 高野裕久, 第23回日本臨床環境医学会, 2014年06月
日本語

関東におけるオゾン関連死亡数の推定　　　　　　　　　　　　　　　
上田佳代, Ng Chris Fook Sheng, 五藤大輔, 有賀敏典, 松橋啓介, Tasmin Saira, 高見昭憲, 第85回日本衛生学会学術総会講演集, 70, S202, 2014年05月
日本語, 研究発表ペーパー・要旨（全国大会，その他学術会議）

関東における熱中症救急搬送数の将来予測　　　　　　　　　　　　　　　
上田佳代, 日本衛生学会雑誌, 69, Supplement, S235, 2014年05月
日本語

微小粒子状物質(PM2.5)と救急搬送との関連:ケースクロスオーバー研究
道川武紘, 上田佳代, 竹内文乃, 木下誠, 林宏巳, 市瀬孝道, 新田裕史, Journal of Epidemiology, 24, Supplement 1, 2014年

PM_2.5の健康影響の疫学的評価手法とその課題
上田佳代, 道川武紘, 新田裕史, 全国環境研究所交流シンポジウム予稿集(Web), 29th, 2014年

黄砂曝露と死亡者数との疫学的関連
橋爪真弘, 西脇祐司, 道川武紘, 上田佳代, 横田賢一, 三根眞理子, 森淳子, 清水厚, 杉本伸夫, エアロゾル研究, 29, S1, S225-S229 (J-STAGE), s229, 2014年
There is increasing concern for possible adverse health effects of Asian dust. In this paper, we reviewed the epidemiological evidence of potential effects of Asian dust events on mortality, from six studies retrieved from PubMed. In addition, one study was identified through a manual search of conference proceedings and reports. Three studies were conducted in Seoul, two in Taipei, and the remaining two in Japan. In Seoul, statistically significant effects of Asian dust on all-cause and circulatory mortality among people 65 years of age or over and respiratory mortality among general population were reported.In Taipei, one study reported a significant effect on cardiovascular mortality and another study reported no significant effect on all-cause and cause-specific mortality. A study of 47 cities in western Japan reported a significant increase in circulatory and respiratory mortality with the increase in Asian dust particles, while no evidence of effects on mortality was reported in the study conducted in Nagasaki., 日本エアロゾル学会, 日本語

長崎県五島市における熱中症予防ランダム化地域比較介入研究
古尾谷 法子, 中尾 理恵子, 上田 佳代, 近藤 正英, 本田 靖, 橋爪 真弘, 日本公衆衛生学会総会抄録集, 72回, 610, 610, 2013年10月
日本公衆衛生学会, 日本語

夏季における気温と室内温度との関係 空調使用の影響
上田 佳代, 小野 雅司, 本田 靖, 橋爪 真弘, 山本 太郎, 日本衛生学雑誌, 68, Suppl., S203, S203, 2013年03月
(一社)日本衛生学会, 日本語

ウツタイン統計を用いた黄砂の健康影響に関する調査研究
西脇祐司, 上田佳代, 久保達彦, 清水厚, 橋爪真弘, 岡村智教, J Epidemiol, 23, Supplement 1, 106, 2013年01月24日
日本語

室内滞在時間を考慮した微小粒子状物質曝露に対する統計的評価
竹内文乃, 上田佳代, 新田裕史, 室内環境学会学術大会講演要旨集, 2013, 2013年

3段階階層モデルで解析をする大気汚染コホート研究の例数設計と検出力計算
竹内文乃, 武林享, 朝倉敬子, 上田佳代, 新田裕史, 塚原照臣, 西脇祐司, 吉村建清, Journal of Epidemiology, 23, Supplement 1, 2013年

熱中症予防情報の家庭配信による行動意識変容―長崎県五島市における介入研究―
古尾谷法子, 中尾理恵子, 上田佳代, 近藤正英, 小野雅司, 本田靖, 橋爪真弘, 日本国際保健医療学会学術大会プログラム・抄録集, 27th, 131, 2012年11月02日
日本語

長崎県五島市における熱中症予防ランダム化地域比較介入研究
古尾谷 法子, 中尾 理恵子, 上田 佳代, 近藤 正英, 小野 雅司, 本田 靖, 橋爪 真弘, 日本公衆衛生学会総会抄録集, 71回, 577, 577, 2012年10月
日本公衆衛生学会, 日本語

地球温暖化に伴う熱中症の被害予測 (2010年夏 日本の猛暑) -- (予測)
小野 雅司, 上田 佳代, 気象研究ノート, 225, 177, 182, 2012年05月
日本気象学会, 日本語

1G1600-4 微小粒子およびその成分の健康影響 : 疫学的手法による評価と課題(都市大気における粒子の生成とその生体影響,7.健康影響分科会&都市大気エアロゾル分科会共催企画)
上田 佳代, 新田 裕史, 大気環境学会年会講演要旨集, 53, 167, 167, 2012年
大気環境学会, 日本語

1A1039 黄砂曝露が救急搬送数に及ぼす影響 : 目視およびライダー観測に基づく黄砂日判定を用いた解析(3影響-1生体,一般研究発表)
上田 佳代, 大気環境学会年会講演要旨集, 53, 180, 180, 2012年
大気環境学会, 日本語

P-90 微小粒子状物質等大気汚染物質による小児の肺機能発達への影響に関するコホート研究(第1報) : 研究デザイン(ポスター発表)
武林 亨, 朝倉 敬子, 新田 裕史, 竹内 文乃, 上田 佳代, 小田嶋 博, 長谷川 就一, 塚原 照臣, 今野 哲, 森川 みき, 向井 奉文, 吉村 健清, 大気環境学会年会講演要旨集, 53, 320, 320, 2012年
大気環境学会, 日本語

PM_<2.5>の健康影響と環境基準
上田 佳代, 新田 裕史, ファルマシア, 47, 3, 253, 258, 2011年03月01日
公益社団法人日本薬学会, 日本語

黄砂の短期曝露による死亡への影響 6市における検討
上田 佳代, 橋爪 真弘, 西脇 祐司, 清水 厚, 西川 雅高, 日本衛生学雑誌, 66, 2, 386, 386, 2011年02月
(一社)日本衛生学会, 日本語

The Effect of Asian Dust Aerosol on Emergency Visits
Kayo Ueda, Hiroshi Nitta, Kenichiro Inoue, EPIDEMIOLOGY, 22, 1, S221, S222, 2011年01月
英語, 研究発表ペーパー・要旨（国際会議）

Long-term Exposure to Particulate Matter and Cardiovascular Mortality in a Representative Japanese Cohort: NIPPON DATA80
Kayo Ueda, Shinya Nagasawa, Hiroshi Nitta, Katsuyuki Miura, Hirotsugu Ueshima, EPIDEMIOLOGY, 22, 1, S79, S79, 2011年01月
英語, 研究発表ペーパー・要旨（国際会議）

The effects of weather, air pollutants, and Asian dust on hospitalization for asthma in Fukuoka
UEDA Kayo, NITTA Hiroshi, ODAJIMA Hiroshi, Environmental health and preventive medicine, 15, 6, 350, 357, 2010年11月01日
英語

黄砂の健康影響 疫学文献レビュー
橋爪 真弘, 上田 佳代, 西脇 祐司, 道川 武紘, 小野塚 大介, 日本衛生学雑誌, 65, 3, 413, 421, 2010年05月
黄砂のヒトへの健康影響について明らかにするため、PubMedを用いて1980〜2009年5月迄の文献を検索し、19件(台湾12、韓国4、中国1、日本1、カナダ1)の文献レビューを行った。近隣諸国の研究報告では黄砂曝露の短期影響として、呼吸器疾患および循環器疾患による死亡や受診・入院患者数増加が報告されているが、統計学的に有意差がみられない文献も多かった。長期影響を検討した文献はなかった。, (一社)日本衛生学会, 日本語

大気中粒子の長期曝露と心血管疾患死亡との関連 NIPPON DATA80による検討　　　　　　　　　　　　　　　
上田 佳代, 長澤 晋哉, 新田 裕史, 三浦 克之, 上島 弘嗣, 日本衛生学雑誌, 65, 2, 305, 305, 2010年04月
日本衛生学会, 日本語

黄砂の健康影響 疫学文献レビュー
橋爪 真弘, 上田 佳代, 西脇 祐司, 道川 武紘, 小野塚 大介, 日本衛生学雑誌, 65, 2, 306, 306, 2010年04月
(一社)日本衛生学会, 日本語

PM_2.5の健康影響~疫学的観点から~
上田佳代, 新田裕史, 全国環境研究所交流シンポジウム予稿集(Web), 25th, 2010年

Specific Chemical Components of Particulate Matter and Daily Mortality in a Japanese Urban City
Kayo Ueda, Hiroshi Nitta, Norio Ito, Akua Mizohata, EPIDEMIOLOGY, 20, 6, S146, S146, 2009年11月
英語, 研究発表ペーパー・要旨（国際会議）

Effects of Fine Particulate Matter on Daily Mortality for Specific Heart Diseases in Japan (vol 73, pg 1248, 2009)
Kayo Ueda, Hiroshi Nitta, Masaji Ono, CIRCULATION JOURNAL, 73, 10, 1972, 1972, 2009年10月
英語, その他

P-46 粒子状物質の成分と死亡との関連 : 堺市における検討(ポスター発表)
上田 佳代, 新田 裕史, 伊藤 憲男, 溝畑 朗, 大気環境学会年会講演要旨集, 50, 338, 338, 2009年
大気環境学会, 日本語

アジアにおける植生火災とその健康影響
国際環境研究協会, 2024年03月, 36683955, ［編者(編著者)］

Particulate Matter/PM2.5 in Handbook of air quality and climate change
Kayo Ueda, Particulate Matter/PM2.5
Springer, 2023年, 9789811527593, xxviii, 745-1549 p. : ill. (some col.) ; 25 cm, 745-763, 英語, ［分担執筆］

Chapter 7. Epidemiological approaches to characterize human health risks from environmental exposure in a watershed. In Environmental Risk Analysis for Asian Oriented Risk Based Watershed Management　　　　　　　　　　　　　　　
上田佳代, 高野裕久
Springer, Singapore, 2018年, ［共著］

Annual Review 呼吸器2015 II. 4. PM2.5と呼吸器疾患　　　　　　　　　　　　　　　
上田佳代, 新田裕史
中外医学社, 2015年01月, ［分担執筆］

Overcoming Environmental Risks to Achieve Sustainable Development Goals Lessons from the Japanese Experience　　　　　　　　　　　　　　　
Yokkaichi Asthma: Health Effects of Air Pollutants in Japan
Springer, 9789811662492, ［分担執筆］

成分データを活用した疫学研究：国内知見と今後の展開　　　　　　　　　　　　　　　
上田佳代
第62回大気環境学会年会, 2021年09月21日, シンポジウム・ワークショップパネル（指名）
［招待講演］

大気汚染の健康影響：日本の事例　　　　　　　　　　　　　　　
上田佳代
IAPSMCON2021, CME on Basics of Health Risk Assessment, 2021年03月16日, 英語, 口頭発表（招待・特別）

Global Health Benefit by Reducing PM2.5 Level
Ueda K, Seposo X, Nakata M, Hanaoka T, Sudo K, Takemura T
2019 Conference of the International Society for Environmental Epidemiology and International Society of Exposure Science- Asia Chapter, シンポジウム・ワークショップパネル（指名）
2019年10月17日 - 2019年10月19日, 13712130, ［招待講演］

確率統計及び演習　　　　　　　　　　　　　　　
京都大学

環境健康科学論　　　　　　　　　　　　　　　
京都大学

環境衛生学　　　　　　　　　　　　　　　
京都大学

難病データベースとイオンビーム工学技術を応用した全身性強皮症の病態解明
科学研究費助成事業
2024年04月01日 - 2028年03月31日
古賀 康彦, 木田 節, 熊谷 貴美代, 石見 拓, 上田 佳代
日本学術振興会, 基盤研究(C), 群馬大学, 24K11594

泥炭地火災による大気汚染と高濃度曝露集団における認知機能と肺機能への影響
科学研究費助成事業
2023年09月08日 - 2027年03月31日
上田 佳代, 戸野倉 賢一, 松島 理明, 大橋 勝文, アタッチャ アティーシャ, 内藤 大輔
日本学術振興会, 国際共同研究加速基金(海外連携研究), 北海道大学, 23KK0165

超微小粒子の時空間分布と嗅覚・中枢神経への急性影響を評価する疫学・毒性学的研究
科学研究費助成事業
2024年04月 - 2027年03月
高見 昭憲, 吉野 彩子, 藤谷 雄二, 伏見 暁洋, 菅田 誠治, 森野 悠, Tin・Tin Win・Shwe, 宇田川 理, 道川 武紘, 上田 佳代, 本間 明宏
日本学術振興会, 基盤研究(A), 国立研究開発法人国立環境研究所, 24H00763

低濃度・非都市部の大気汚染の健康影響：船舶排ガス規制の健康インパクト
科学研究費助成事業
2023年04月01日 - 2026年03月31日
上田 佳代, 須崎 純一, 橋爪 真弘, ウン クリス・フック・シェン, SEPOSO XERXES, 木村 優介
日本学術振興会, 基盤研究(B), 北海道大学, 23K27848

低濃度・非都市部の大気汚染の健康影響：船舶排ガス規制の健康インパクト
科学研究費助成事業
2023年04月01日 - 2026年03月31日
上田 佳代, 須崎 純一, 橋爪 真弘, ウン クリス・フック・シェン, SEPOSO XERXES, 木村 優介
日本学術振興会, 基盤研究(B), 北海道大学, 23H03158

極端高温等が暑熱健康に及ぼす影響と適応策に関する研究　　　　　　　　　　　　　　　
環境研究総合推進費
2023年04月 - 2026年03月
環境再生保全機構, 国立環境研究所, 研究分担者

短寿命気候強制因子による健康影響の定量的評価
環境研究総合推進費
2021年04月 - 2026年03月
Karo Ueda, Seposo Xerxes, Muhammad Abdul Basit Ahmad Tajudin
独立行政法人環境再生保全機構, 北海道大学, 研究代表者

大気浄化、公衆衛生および持続可能な農業を目指す学際研究：北インドの藁焼きの事例
総合地球環境学研究所 実践プロジェクト
2025年03月
総合地球環境学研究所

大気汚染の健康影響の時空間変動評価と衛星画像を活用した影響修飾要因の解明
科学研究費助成事業 基盤研究(B)
2020年04月01日 - 2023年03月31日
上田 佳代, 橋爪 真弘, 須崎 純一, ウン クリス・フック・シェン, SEPOSO XERXES
日本学術振興会, 基盤研究(B), 京都大学, 20H03942

国際民間航空機関の規制に対応した航空機排出粒子状物質の健康リスク評価と対策提案
環境研究総合推進費
2019年04月 - 2023年03月
竹川 暢之
独立行政法人 環境再生保全機構

微小粒子状物質（PM2.5）と粒子成分が不整脈発生や心拍変動に及ぼす影響
科学研究費助成事業
2016年04月01日 - 2020年03月31日
上田 佳代, 早野 順一郎, 植田 典浩, 清野 健
本研究では、大気汚染物質のうち、粒子径が2.5μm以下の微小粒子状物質（PM2.5)の曝露による自律神経への影響を明らかにするために、。ALLSTAR研究で整備された全国のHolter心電図（24時間の心電図記録）と、地域で観測されたPM2.5濃度の情報を組み合わせた疫学研究を行った。この研究から、PM2.5濃度が高い日およびそれから数日後にかけて、心拍のゆらいの指標が低下することが分かった。この心拍変動は自律神経の活動状態を反映しており、心拍変動指標の低下は心疾患や心臓突然死のリスク増加と関係している。この疫学研究で、PM2.5曝露から心臓疾患発生に至るメカニズムの1つが明らかになった。
日本学術振興会, 基盤研究(C), 京都大学, 16K09097

インドネシア熱帯泥炭火災からの大気汚染物質曝露による健康インパクトの包括的評価
国際共同研究加速基金(国際共同研究強化(B))
2018年 - 2020年
戸野倉賢一
文部科学省, 競争的資金

微小(PM2.5)及び粗大粒子状物質が脳卒中発症や死亡に及ぼす短期曝露影響に関する研究
環境研究総合推進費
2017年 - 2019年
高見昭憲
環境再生保全機構, 競争的資金

粒子状物質成分曝露が心電図変化と生命予後に及ぼす影響に関する研究
科学研究費補助金・基盤研究(C)
2016年 - 2019年
早野順一郎、植田典浩、清野健
文部科学省, 研究代表者, 競争的資金

短寿命大気汚染物質による気候変動に伴う健康へのインパクト評価
環境研究総合推進費・委託費S12-3-3
2014年 - 2019年
上田佳代
環境再生保全機構, 研究代表者, 競争的資金

越境大気汚染に含まれる粒子成分が循環器疾患発症に及ぼす影響
科学研究費助成事業
2012年04月01日 - 2015年03月31日
新田 裕史, 高見 昭憲, 森野 悠, 北園 孝成, 鴨打 正浩, 上田 佳代, 道川 武紘, 山本 雄祐, 吉野 彩子
本課題では、北部九州における大気観測、PM2.5の成分分析、大気シミュレーションを用いて越境大気汚染の寄与を推定するとともに、それらの大気データを曝露情報として循環器疾患発症登録データと結合して疫学研究を行った。観測や大気シミュレーションの結果より、北部九州地域では、越境大気汚染物質の寄与が大きいことが示された。
疫学研究では、黄砂飛来により脳梗塞や心筋梗塞の発症リスクが上昇することが示された。一方、PM2.5濃度の短期曝露により、脳梗塞発症のリスクが増加する可能性が示された。また、特定の粒子成分と心筋梗塞との間に正の関連がみられた。
日本学術振興会, 基盤研究(B), 独立行政法人国立環境研究所, 24310024

大陸に由来するアジアンスモッグ(煙霧)の疫学調査と実験研究による生体影響解明　　　　　　　　　　　　　　　
科学研究費補助金・基盤研究(A)
2013年 - 2015年
市瀬孝道
文科省, 競争的資金

黄砂による日常症状に見られる健康被害に関する広域調査研究
科学研究費助成事業
2011年 - 2013年
赤羽 学, 今村 知明, 高野 裕久, 上田 佳代, 清水 厚
我々がこれまでに確立したインターネットを介した健康調査システムを用いて、アレルギー症状を日々収集し、黄砂飛来量・花粉飛散量との関係をみた。各症状の有無を従属変数とし、対象者の性別、年齢と各調査日の最高気温、湿度、黄砂量を共変数として一般化推定方程式を用いて分析した。
アレルギー症状の有症状率は2月上旬から増加傾向を示し、黄砂の大量飛来日を起点として増加していた。黄砂量と関連が強かった症状は、鼻水、咳、目のかゆみであった。本研究では、黄砂によってアレルギー症状が誘発されている可能性が示唆されただけでなく、花粉症患者においては花粉飛散量と不眠にも関連があることが判明した。
日本学術振興会, 基盤研究(C), 奈良県立医科大学, 23510033

東アジア・東南アジアの大気汚染による健康影響の評価
科学研究費助成事業
2008年 - 2012年
本田 靖, 中井 里史, 小野 雅司, 田村 憲治, 新田 裕史, 上田 佳代
本研究は,東アジアにおけるエアロゾルの健康影響,特に死亡への影響を,疫学的手法を用いて明らかにしようとした.日本,韓国,台湾の主要都市における粒子状物質濃度,日別死亡数などのデータを収集した.福岡市など九州地域では粒子状物質濃度に越境汚染の影響が示唆されたが,東京などでは大きな影響は見られなかった.死亡への影響ははっきりしなかったが,福岡で大きいという可能性が示唆された.
日本学術振興会, 新学術領域研究(研究領域提案型), 筑波大学, 20120013

黄砂エアロゾルが救急外来受診に及ぼす影響の疫学的検討
科学研究補助金 新学術領域研究（公募研究）
2009年 - 2010年
上田佳代
本研究は、黄砂の健康に対する急性影響を評価するために、長崎において、越境汚染の指標である黄砂飛来と救急外来受診との関連について明らかにすることを目的とした。
予備調査として、文献レビューおよび、福岡における呼吸器疾患のデータを用いた解析を行い、それらの結果を論文として学術雑誌に投稿した。文献レビューにおいては、黄砂の健康影響に関するエビデンスが十分でなく、今後の課題として論じた。
本調査として、平成22年度には、長崎市救急実態調査の救急搬送データ、長崎市内の5か所から得た大気汚染物質濃度データ、を用いた解析を行ったところ、SPM濃度上昇により、呼吸器疾患による救急搬送との間に有意な正の関連を認めた。
一方、黄砂の健康影響評価にあたり、黄砂日について異なる指標を用いた解析を行った。目視による黄砂判定を用いた解析では、救急搬送の前日、2日前、3日前が黄砂日であった場合のリスクは上昇し、救急搬送当日から3日前までの間いずれかの日に黄砂日があった場合の救急搬送リスク変化率は、4.3%(95%CI : -0.7,9.5)であった。ライダー観測による黄砂消散係数に基づいて判定された黄砂日における救急搬送リスクを評価するために、高度120mにおける黄砂消散係数の値が閾値(0.13/km)を越えた日を黄砂日とし、非黄砂日に比較した黄砂日の救急搬送リスクの変化率を算出したところ、黄砂曝露による救急リスクは10.2%(95%CI : 0.6,20.6)上昇したことを見出し、黄砂消散係数を用いた黄砂判定による健康影響評価の有用性を明らかにした。さらに、後方流跡線解析の結果により黄砂日を分類し、救急搬送リスクの大きさについて比較したところ、工業地帯を通過した黄砂粒子の曝露により、救急搬送リスクが上昇する可能性を示した。
文部科学省, 新学術領域研究(研究領域提案型), 独立行政法人国立環境研究所, 研究代表者, 競争的資金, 21120511