Kakisaka Tatsuhiko
| Faculty of Medicine Surgery Surgery | Lecturer |
| Hokkaido University Hospital | Lecturer |
Last Updated :2025/06/07
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Educational Organization
- Bachelor's degree program, Departments of Medicine, School of Medicine
- Master's degree program, Graduate School of Medicine
- Doctoral (PhD) degree program, Graduate School of Medicine
■Career
■Research activity information
Papers
- Site-Specific O-Glycosylation in Oncofetal Fibronectin IIICS Domain Creates Cancer Stage-Specific Biomarkers.
Nozomi Hirane, Yasuhiro Yokoi, Aiko Kobayashi, Misaki Yamada, Taiki Konno, Hiroyuki Kumeta, Hajime Wakui, Michiru Otaki, Yoshiaki Miura, Tatsuhiko Kakisaka, Toshiya Kamiyama, Akinobu Taketomi, Kazuhiro Nouso, Satoshi Kimura, Shin-Ichiro Nishimura
Journal of the American Chemical Society, 147, 14, 12170, 12184, 09 Apr. 2025, [International Magazine]
English, Scientific journal, Despite the pathological importance of oncofetal fibronectin isoforms associated with cancer cell progression and metastasis, our understanding of the structural and molecular details that occurred in this abundant and ubiquitous extracellular matrix component remains largely unknown. Here, we communicate that site-specific O-glycosylation in the oncofetal fibronectin creates cancer stage-specific serum biomarkers for hepatocellular carcinoma (HCC) by quantitative MS-based glycoproteomic approach. Selective reaction monitoring (SRM) using a structure-defined synthetic glycopeptide library enabled absolute quantitation of the targeted label-free tryptic fragments bearing cancer-relevant O-glycans derived from the type III homology connective segment (IIICS) domain of the oncofetal fibronectin (onfFN) in the sera of HCC patients and healthy controls. We found site-specific O-glycoform alteration from T/sialyl T antigens to Tn/sialyl Tn antigens at the consecutive threonine residues 2155Thr-Thr-Ala2157 within this fragment during cancer progression. Surprisingly, this dynamic glycoform alteration is observed specifically in the patient sera diagnosed newly as stage 2-4 groups not in the normal control and stage 1 patient groups. Our results provide compelling evidence that site-specific glycoform changes observed in the onfFN IIICS domain during the tumor proliferation elaborate new class cancer stage-relevant "dynamic epitopes" as highly potential cancer diagnostic and therapeutic targets. - Normal tissue complication probability model for severe radiation-induced lymphopenia in patients with pancreatic cancer treated with concurrent chemoradiotherapy
Fuki Koizumi, Norio Katoh, Takahiro Kanehira, Yasuyuki Kawamoto, Toru Nakamura, Tatsuhiko Kakisaka, Miyako Myojin, Noriaki Nishiyama, Akio Yonesaka, Manami Otsuka, Rikiya Takashina, Hideki Minatogawa, Hajime Higaki, Yusuke Uchinami, Hiroshi Taguchi, Kentaro Nishioka, Koichi Yasuda, Naoki Miyamoto, Isao Yokota, Keiji Kobashi, Hidefumi Aoyama
Physics and Imaging in Radiation Oncology, 100690, 100690, Elsevier BV, Dec. 2024
Scientific journal - 分子標的薬がBCLC stage Cの肝細胞癌の手術成績に与えた影響
旭 よう, 柿坂 達彦, 折茂 達也, 長津 明久, 相山 健, 脇坂 和貴, 志智 俊介, 武冨 紹信
日本癌治療学会学術集会抄録集, 62回, O16, 5, (一社)日本癌治療学会, Oct. 2024
English - Improved survival outcome of curative liver resection for Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma in the era of tyrosine kinase inhibitors.
Yoh Asahi, Tatsuhiko Kakisaka, Toshiya Kamiyama, Tatsuya Orimo, Shingo Shimada, Akihisa Nagatsu, Takeshi Aiyama, Yuzuru Sakamoto, Kazuki Wakizaka, Shunsuke Shichi, Hirofumi Kamachi, Akinobu Taketomi
Hepatology research : the official journal of the Japan Society of Hepatology, 26 Jul. 2024, [International Magazine]
English, Scientific journal, AIM: This study was undertaken to evaluate the outcome of curative liver resection, (LR) of Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma (BCLC-C HCC) after tyrosine kinase inhibitors (TKIs) became approved as a treatment option for recurrent lesions. METHODS: Sixty-seven patients with BCLC-C HCC who underwent curative LR were enrolled in this study. The patients were classified into two groups according to whether LR was performed before (n = 24) or after (n = 43) TKI approval ("beforeTKI" and "afterTKI" group, respectively). RESULTS: There was no difference in the median disease-free survival time after LR between the beforeTKI and afterTKI groups (5.6 and 7.1 months, respectively; p = 0.435). However, the median survival time after LR was longer in the afterTKI than beforeTKI group (42.7 and 14.9 months, respectively; p = 0.022). Univariate and multivariate analyses showed that the date of LR was the only independent factor affecting postresection survival. When the patients were limited to those with recurrence, there were no differences in the recurrence pattern or progression of HCC at the time of recurrence between the two groups. The only difference in the treatment distribution was the administration of TKIs (14 of 34 patients in afterTKI group and only 1 of 19 patients in beforeTKI group, p < 0.001). CONCLUSION: These data suggest that TKI therapy for recurrent BCLC-C HCC is associated with improved overall survival. Thus, LR could be a promising option for BCLC-C HCC in the current era of TKI therapy. - Diacylglycerol kinase alpha is a proliferation marker of intrahepatic cholangiocarcinoma associated with the prognosis.
Shunsuke Shichi, Ko Sugiyama, Yoh Asahi, Chisato Shirakawa, Hiroki Nakamoto, Saori Kimura, Kazuki Wakizaka, Takeshi Aiyama, Akihisa Nagatsu, Tatsuya Orimo, Tatsuhiko Kakisaka, Akinobu Taketomi
Cancer medicine, 13, 9, e7238, May 2024, [International Magazine]
English, Scientific journal, BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) has a high recurrence rate and a poor prognosis. Thus, the development of effective treatment and prognostic biomarkers is required. High expression of diacylglycerol kinase alpha (DGKα) is a prognostic factor for the recurrence of hepatocellular carcinoma. However, the relationship between DGKα expression and prognosis in ICC has not been reported. METHODS: Immunohistochemistry (IHC) with anti-DGKα antibody was performed on surgical specimens of ICC (n = 69). First, DGKα expression in cancer cells was qualitatively classified into four groups (-, 1+, 2+, 3+) and divided into two groups (DGKα- and DGKα+1 + to 3+). The relationship between clinical features and DGKα expression was analyzed. Second, Ki-67 expression was evaluated as a cell proliferation marker. The number of Ki-67-positive cells was counted, and the relationship with DGKα expression was examined. RESULTS: DGKα IHC divided the patients into a DGKα+ group (1+: n = 15; 2+: n = 5; 3+: n = 5) and a DGKα- group (-: n = 44). In the DGKα+ group, patients were older and had advanced disease. Both overall survival and recurrence-free survival (RFS) were significantly worse in the DGKα+ patients. DGKα+ was identified as an independent prognostic factor for RFS by multivariate analysis. Furthermore, the number of Ki-67-positive cells increased in association with the staining levels of DGKα. CONCLUSION: Pathological DGKα expression in ICC was a cancer proliferation marker associated with recurrence. This suggests that DGKα may be a potential therapeutic target for ICC. - 結腸がん切除手術における手縫い吻合と器械吻合の実施状況と臨床的アウトカムに関するDPCデータを用いた研究
海老沼 翔太, 國澤 進, 愼 重虎, 伏見 清秀, 市川 伸樹, 吉田 雅, 柿坂 達彦, 本間 重紀, 武冨 紹信, 今中 雄一
日本外科学会定期学術集会抄録集, 124回, SF, 5, (一社)日本外科学会, Apr. 2024
Japanese - 結腸がん切除手術における手縫い吻合と器械吻合の実施状況と臨床的アウトカムに関するDPCデータを用いた研究
海老沼 翔太, 國澤 進, 愼 重虎, 伏見 清秀, 市川 伸樹, 吉田 雅, 柿坂 達彦, 本間 重紀, 武冨 紹信, 今中 雄一
日本外科学会定期学術集会抄録集, 124回, SF, 5, (一社)日本外科学会, Apr. 2024
Japanese - 肝内胆管癌における術前リンパ節転移評価およびリンパ節郭清の臨床的意義
志智 俊介, 脇坂 和貴, 相山 健, 長津 明久, 折茂 達也, 柿坂 達彦, 武冨 紹信
日本外科学会定期学術集会抄録集, 124回, PS, 1, (一社)日本外科学会, Apr. 2024
Japanese - 肝再生分子機構におけるDGKαの新しい機能解析
中本 裕紀, 鈴木 琢士, 白川 智沙斗, 志智 俊介, 長津 明久, 折茂 達哉, 柿坂 達彦, 北村 秀光, 武冨 紹信
日本外科学会定期学術集会抄録集, 124回, PS, 7, (一社)日本外科学会, Apr. 2024
Japanese - 再肝切除症例に対する低侵襲手術の工夫と注意点
長津 明久, 柿坂 達彦, 志智 俊介, 脇坂 和貴, 相山 健, 折茂 達也, 武冨 紹信
日本外科学会定期学術集会抄録集, 124回, PS, 6, (一社)日本外科学会, Apr. 2024
Japanese - 切除不能肝細胞癌に対してアテゾリズマブ・ベバシズマブ併用療法後にconversion surgeryを施行し得た3症例
小林 正幸, 相山 健, 柿坂 達彦, 折茂 達也, 長津 明久, 脇坂 和貴, 志智 俊介, 清水 亜衣, 大川 紘弥, 武冨 紹信
日本外科学会定期学術集会抄録集, 124回, PS, 4, (一社)日本外科学会, Apr. 2024
Japanese - Child-Pugh分類Bの肝細胞癌に対する肝切除術の検討
脇坂 和貴, 志智 俊介, 相山 健, 長津 明久, 折茂 達也, 柿坂 達彦, 武冨 紹信
日本外科学会定期学術集会抄録集, 124回, PS, 4, (一社)日本外科学会, Apr. 2024
Japanese - 当科における胆道癌に対する肝膵同時切除症例の臨床病理学的検討
柿坂 達彦, 折茂 達也, 長津 明久, 相山 健, 脇坂 和貴, 志智 俊介, 武冨 紹信
日本外科学会定期学術集会抄録集, 124回, PS, 7, (一社)日本外科学会, Apr. 2024
Japanese - 術前に肝硬化性血管腫との鑑別に難渋した細胆管細胞癌の1切除例
森越 健之介, 脇坂 和貴, 志智 俊介, 相山 健, 長津 明久, 折茂 達也, 柿坂 達彦, 武冨 紹信
日本外科学会定期学術集会抄録集, 124回, RS, 4, (一社)日本外科学会, Apr. 2024
Japanese - Treatment of delayed pancreatic fistula associated with anastomosis breakdown after pancreaticoduodenectomy using percutaneous interventions.
Reimi Suzuki, Yuji Konishi, Kai Makino, Yosuke Wakui, Kazuhiro Mino, Hideki Kawamura, Ryo Morita, Tatsuhiko Kakisaka, Daisuke Abo, Akinobu Taketomi
Clinical journal of gastroenterology, 17, 2, 356, 362, Apr. 2024, [Domestic magazines]
English, Scientific journal, We here present a rare case of development of a postoperative pancreatic fistula and breakdown of the pancreaticojejunal anastomosis 8 months after pancreaticoduodenectomy. A 70-year-old man underwent pancreaticoduodenectomy for distal cholangiocarcinoma and initially recovered well. However, 8 months later, he developed abdominal pain and distention and was admitted to our institution with suspected pancreatitis. On the 17th day of hospitalization, he suddenly bled from the jejunal loop and a fluid collection was detected near the pancreaticojejunal anastomosis site. The fluid collection was drained percutaneously. Subsequent fistulography confirmed breakdown of the pancreaticojejunal anastomosis. Considering the patient's overall condition and the presence of postoperative adhesions, we decided to manage him conservatively. An additional drain tube was placed percutaneously from the site of the anastomotic breakdown into the lumen of the jejunum, along with the tube draining the fluid collection, creating a completely new fistula. This facilitated the flow of pancreatic fluid into the jejunum and was removed 192 days after placement. During a 6-month follow-up, there were no recurrences of pancreatitis or a pancreatic fistula. This case highlights the efficacy of percutaneous drainage and creation of an internal fistula as a management strategy for delayed pancreatic fistula and anastomotic breakdown following pancreaticoduodenectomy. - Expression of Wnt5a and ROR2, Components of the Noncanonical Wnt-Signaling Pathway, is Associated with Tumor Differentiation in Hepatocellular Carcinoma.
Kazuki Wakizaka, Toshiya Kamiyama, Tatsuhiko Kakisaka, Tatsuya Orimo, Akihisa Nagatsu, Takeshi Aiyama, Shunsuke Shichi, Akinobu Taketomi
Annals of surgical oncology, 31, 1, 262, 271, Jan. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: Wnt5a is the key ligand of the noncanonical Wnt pathway, and receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a receptor associated with Wnt5a. The association between the noncanonical Wnt-signaling pathway and carcinogenesis in hepatocellular carcinoma (HCC) is unclear. This study investigated the significance of ROR2 expression in HCC. METHODS: The study examined ROR2 expression in liver cancer cell lines. Immunohistochemical staining of ROR2 was performed on 243 resected HCC specimens. The study investigated ROR2 expression and its association with clinicopathologic factors and prognosis. RESULTS: Findings showed that ROR2 was expressed in well-differentiated Huh7 and HepG2 cells, but not in poorly differentiated HLE and HLF cells. Expression of ROR2 was positive in 147 (60.5%) and negative in 96 (39.5%) HCC specimens. A significant association was shown between ROR2 negativity and high alpha-fetoprotein (AFP) level (P = 0.006), poor differentiation (P = 0.015), and Wnt5a negativity (P = 0.024). The 5-year overall survival (OS) rate for the ROR2-negative group (64.2 %) tended to be worse than for the ROR2-positive group (73.8%), but the difference was not significant (P = 0.312). The 5-year OS rate was 78.7% for the ROR2+Wnt5a+ group, 71.3 % for the ROR2+Wnt5a- group, 80.8% for the ROR2-Wnt5a+ group, and 60.5 % for the ROR2-Wnt5a- group. The OS in the ROR2-Wnt5a- group was significantly poorer than in the ROR2+Wnt5a+ group (P = 0.030). The multivariate analysis showed that Wnt5a-ROR2- was an independent prognostic factor (hazard ratio, 2.058; 95% confidence interval, 1.013-4.180; P = 0.045). CONCLUSIONS: The combination of ROR2 and Wnt5a may be a prognostic indicator for HCC. The Wnt5a/ROR2 signal pathway may be involved in the differentiation of HCC. This pathway may be a new therapeutic target for HCC. - Real-time tumor-tracking radiotherapy with SyncTraX for primary liver tumors requiring isocenter shift†.
Yusuke Uchinami, Naoki Miyamoto, Daisuke Abo, Ryo Morita, Koji Ogawa, Tatsuhiko Kakisaka, Ryusuke Suzuki, Tomohiko Miyazaki, Hiroshi Taguchi, Norio Katoh, Hidefumi Aoyama
Journal of radiation research, 22 Nov. 2023, [International Magazine]
English, Scientific journal, The SyncTraX series enables real-time tumor-tracking radiotherapy through the real-time recognition of a fiducial marker using fluoroscopic images. In this system, the isocenter should be located within approximately 5-7.5 cm from the marker, depending on the version, owing to the limited field of view. If the marker is placed away from the tumor, the isocenter should be shifted toward the marker. This study aimed to investigate stereotactic body radiotherapy (SBRT) outcomes of primary liver tumors treated with SyncTraX in cases where the isocenter was shifted marginally or outside the planning target volume (PTV). Twelve patients with 13 liver tumors were included in the analysis. Their isocenter was shifted toward the marker and was placed marginally or outside the PTV. The prescribed doses were generally 40 Gy in four fractions or 48 Gy in eight fractions. The overall survival (OS) and local control (LC) rates were calculated using the Kaplan-Meier method. All patients completed the scheduled SBRT. The median distance between the fiducial marker and PTV centroid was 56.0 (interquartile range [IQR]: 52.7-66.7) mm. By shifting the isocenter toward the marker, the median distance between the marker and isocenter decreased to 34.0 (IQR: 33.4-39.7) mm. With a median follow-up period of 25.3 (range: 6.9-70.0) months, the 2-year OS and LC rates were 100.0% (95% confidence interval: 100-100). An isocenter shift makes SBRT with SyncTraX feasible in cases where the fiducial marker is distant from the tumor. - 【COVID-19のみならず!肝胆膵と感染症】肝胆膵診療での感染症各論 日常臨床における肝エキノコックス症
相山 健, 柿坂 達彦, 折茂 達也, 長津 明久, 脇坂 和貴, 志智 俊介, 岡田 宏美, 武冨 紹信
肝胆膵, 87, 3, 287, 294, (株)アークメディア, Sep. 2023
Japanese - Lymphaticovenous anastomosis for treatment of refractory chylous ascites: A case report.
Shoichi Tsuzaka, Takeshi Aiyama, Hirofumi Kamachi, Tatsuhiko Kakisaka, Tatsuya Orimo, Akihisa Nagatsu, Yoh Asahi, Taku Maeda, Toshiya Kamiyama, Akinobu Taketomi
Microsurgery, 43, 6, 606, 610, Sep. 2023, [International Magazine]
English, Chylous ascites, the leakage of lymphatic fluid into the abdominal cavity caused by lymphatic fluid stasis or lymphatic vessel damage, can be treated by lymphaticovenous anastomosis (LVA). We report rarely performed abdominal LVA to treat a case of refractory ascites possibly caused by ligation of the thoracic duct and pleurodesis in a man aged 60 years requiring weekly ascites drainage. Ligation was abandoned because the leakage site was not determined. The greater omentum (GO) was generally edematous and showed lymphatic effusion by gross appearance, and was considered suitable for LVA. We performed once LVA in the lymphatic vessels and veins of the GO using common microsurgical instrumentation and lateral anastomosis. Lymphatic vessels in the omentum were dilated to 2-3 mm, and LVA was simple. After LVA, GO edema improved. Postoperatively, the patient developed paralytic ileus, which improved within a few days, and the patient was discharged without any increase in ascites after starting to diet. One year post-surgery, there was no recurrence of ascites. LVA at the GO may be effective for the treatment of refractory chylous ascites because of its absorptive lymphatic draining capabilities and large transverse vessels. - 肝細胞癌におけるWntシグナル伝達経路受容体ROR2の発現についての検討
脇坂 和貴, 志智 俊介, 相山 健, 長津 明久, 折茂 達也, 柿坂 達彦, 三橋 智子, 武冨 紹信
日本消化器外科学会総会, 78回, P100, 6, (一社)日本消化器外科学会, Jul. 2023
Japanese - 【肝胆膵外科手術における術中トラブルシューティング】肝臓 開腹肝切除における肝門操作時の門脈・肝動脈損傷への対処法
長津 明久, 柿坂 達彦, 折茂 達也, 相山 健, 脇坂 和貴, 志智 俊介, 武冨 紹信
外科, 85, 8, 868, 873, (株)南江堂, Jul. 2023
Japanese - 腹部手術後門脈狭窄/閉塞に対する門脈ステント留置による血液検査データ変化に関する検討
木野田 直也, 阿保 大介, 木村 輔, 作原 祐介, 藤井 宝顕, 加藤 大祐, 高橋 文也, 森田 亮, 折茂 達也, 柿坂 達彦, 中村 透, 平野 聡, 箕輪 和行, 工藤 與亮
日本インターベンショナルラジオロジー学会雑誌, 38, Suppl., 205, 205, (一社)日本インターベンショナルラジオロジー学会, Apr. 2023
Japanese - 肝エキノコックス症による右肝静脈狭窄に対してcovered stentを留置した一例
渡辺 祈一, 阿保 大介, 森田 亮, 木野田 直也, 高橋 文也, 加藤 大祐, 藤井 宝顕, 柿坂 達彦, 折茂 達也, 工藤 與亮
日本インターベンショナルラジオロジー学会雑誌, 38, Suppl., 277, 277, (一社)日本インターベンショナルラジオロジー学会, Apr. 2023
Japanese - 肝切除術後の門脈血栓症に対する治療の検討
脇坂 和貴, 相山 健, 長津 明久, 折茂 達也, 柿坂 達彦, 武冨 紹信
日本外科学会定期学術集会抄録集, 123回, DP, 4, (一社)日本外科学会, Apr. 2023
Japanese - 腹部手術後門脈狭窄/閉塞に対する門脈ステント留置による血液検査データ変化に関する検討
木野田 直也, 阿保 大介, 木村 輔, 作原 祐介, 藤井 宝顕, 加藤 大祐, 高橋 文也, 森田 亮, 折茂 達也, 柿坂 達彦, 中村 透, 平野 聡, 箕輪 和行, 工藤 與亮
日本インターベンショナルラジオロジー学会雑誌, 38, Suppl., 205, 205, (一社)日本インターベンショナルラジオロジー学会, Apr. 2023
Japanese - 肝エキノコックス症による右肝静脈狭窄に対してcovered stentを留置した一例
渡辺 祈一, 阿保 大介, 森田 亮, 木野田 直也, 高橋 文也, 加藤 大祐, 藤井 宝顕, 柿坂 達彦, 折茂 達也, 工藤 與亮
日本インターベンショナルラジオロジー学会雑誌, 38, Suppl., 277, 277, (一社)日本インターベンショナルラジオロジー学会, Apr. 2023
Japanese - Study of hepatic toxicity in small liver tumors after photon or proton therapy based on factors predicting the benefits of proton.
Yusuke Uchinami, Norio Katoh, Daisuke Abo, Ryo Morita, Hiroshi Taguchi, Yoshihiro Fujita, Takahiro Kanehira, Ryusuke Suzuki, Naoki Miyamoto, Seishin Takao, Taeko Matsuura, Takuya Sho, Koji Ogawa, Tatsuya Orimo, Tatsuhiko Kakisaka, Keiji Kobashi, Hidefumi Aoyama
The British journal of radiology, 96, 1144, 20220720, 20220720, 12 Jan. 2023, [International Magazine]
English, Scientific journal, OBJECTIVES: In a previous study of hepatic toxicity, the following three factors were identified to predict the benefits of proton beam therapy (PBT) for hepatocellular carcinomas (HCC) with a maximum diameter of ≤5 cm and Child-pugh grade A (CP-A): number of tumors (one vs ≥2), the location of tumors (hepatic hilum or others), and the sum of the diameters of lesions. The aim of this study is to analyze the association between these three factors and hepatic toxicity. METHODS: We retrospectively reviewed patients of CP-A treated with PBT or photon stereotactic body radiotherapy (X-ray radiotherapy, XRT) for HCC ≤5 cm. For normal liver dose, the V5, V10, V20 (volumes receiving 5, 10, and 20 Gy at least), and the mean dose was evaluated. The albumin-bilirubin (ALBI) and CP score changes from the baseline were evaluated at 3 and 6 months after treatment. RESULTS: In 89 patients (XRT: 48, PBT: 41), those with two or three (2-3) predictive factors were higher normal liver doses than with zero or one (0-1) factor. In the PBT group, the ALBI score worsened more in patients with 2-3 factors than those with 0-1 factor, at 3 months (median 0.26 vs 0.02, p = 0.032) and at 6 months (median: 0.35 vs 0.10, p = 0.009). The ALBI score change in the XRT group and CP score change in either modality were not significantly different in the number of predictive factors. CONCLUSIONS: The predictive factor numbers predicted the ALBI score change in PBT but not in XRT. ADVANCES IN KNOWLEDGE: This study suggest that the number of predictive factors previously identified (0-1 vs 2-3) were significantly associated with dosimetric parameters of the normal liver in both modalities. In the proton group, the number of predictive factors was associated with a worsening ALBI score at 3 and 6 months, but these associations were not found in the photon SBRT group. - Preoperative Sustained C-Reactive Protein Elevation Impairs Patient Survival after Liver Resection for Perihilar Cholangiocarcinoma
Tatsuhiko Kakisaka
Journal of the American College of Surgeons, 2023
Scientific journal - 肝切除におけるナビゲーション 3次元画像解析システムを応用した肝切除
折茂 達也, 柿坂 達彦, 長津 明久, 相山 健, 脇坂 和貴, 武冨 紹信
日本臨床外科学会雑誌, 83, 増刊, S170, S170, 日本臨床外科学会, Oct. 2022
Japanese - ASO Visual Abstract: Hepatectomy is Beneficial for Select Patients with Multiple Hepatocellular Carcinomas.
Tatsuya Orimo, Toshiya Kamiyama, Tatsuhiko Kakisaka, Akihisa Nagatsu, Yoh Asahi, Takeshi Aiyama, Hirofumi Kamachi, Akinobu Taketomi
Annals of surgical oncology, 29, 13, 8448, 8448, 30 Sep. 2022, [International Magazine]
English, Scientific journal - Hepatectomy is Beneficial in Select Patients with Multiple Hepatocellular Carcinomas.
Tatsuya Orimo, Toshiya Kamiyama, Tatsuhiko Kakisaka, Akihisa Nagatsu, Yoh Asahi, Takeshi Aiyama, Hirofumi Kamachi, Akinobu Taketomi
Annals of surgical oncology, 29, 13, 8436, 8445, 13 Sep. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: A single hepatocellular carcinoma (HCC) is a good indication for hepatic resection regardless of tumor size, but the surgical indications for cases with multiple HCCs remain unclear. METHODS: We retrospectively reviewed the outcomes of hepatectomies for Barcelona Clinic Liver Cancer (BCLC) stage 0, A, and B HCCs. We further subclassified stage A and B into A1 (single nodule <5 cm, or three or fewer nodules ≤3 cm), A2 (single nodule 5-10 cm), A3 (single nodule ≥10 cm), B1 (two to three nodules >3 cm), and B2 (four or more nodules). RESULTS: A total of 1088 patients were enrolled, comprising 88 stage 0, 750 stage A (A1: 485; A2: 190; A3: 75), and 250 stage B (B1: 166; B2: 84) cases. The 5-year overall survival (OS) rates for stage 0, A1, A2, A3, B1, and B2 patients were 70.4%, 74.2%, 63.8%, 47.7%, 47.5%, and 31.9%, respectively (p < 0.0001). Significant differences in OS were found between stages A1 and A2 (p = 0.0118), A2 and A3 (p = 0.0013), and B1 and B2 (p = 0.0050), but not between stages A3 and B1 (p = 0.4742). In stage B1 patients, multivariate analysis indicated that Child-Pugh B cirrhosis was the only independent prognostic factor for the OS outcome. CONCLUSIONS: A hepatectomy should be considered for multiple HCCs if the number of tumors is three or fewer, especially in patients with no cirrhosis or in Child-Pugh A cases, because the long-term results are equivalent to those for a single HCC. - Conversion surgery after lenvatinib treatment for multiple lung metastases from hepatocellular carcinoma
Shunji Sano, Yoh Asahi, Toshiya Kamiyama, Tatsuhiko Kakisaka, Tatsuya Orimo, Akihisa Nagatsu, Takeshi Aiyama, Keizo Kazui, Hiroki Shomura, Shinya Ueki, Yuzuru Sakamoto, Chisato Shirakawa, Hirofumi Kamachi, Hirokazu Sugino, Tomoko Mitsuhashi, Akinobu Taketomi
INTERNATIONAL CANCER CONFERENCE JOURNAL, Aug. 2022
English, Scientific journal - Impact of comorbid renal dysfunction in patients with hepatocellular carcinoma on long-term outcomes after curative resection.
Yuzuru Sakamoto, Shingo Shimada, Toshiya Kamiyama, Ko Sugiyama, Yoh Asahi, Akihisa Nagatsu, Tatsuya Orimo, Tatsuhiko Kakisaka, Hirofumi Kamachi, Yoichi M Ito, Akinobu Taketomi
World journal of gastrointestinal surgery, 14, 7, 670, 684, 27 Jul. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. However, the number of patients with chronic kidney disease (CKD) is on the rise because of the increase in lifestyle-related diseases. AIM: To establish a tailored management strategy for HCC patients, we evaluated the impact of comorbid renal dysfunction (RD), as stratified by using the estimated glomerular filtration rate (EGFR), and assessed the oncologic validity of hepatectomy for HCC patients with RD. METHODS: We enrolled 800 HCC patients who underwent hepatectomy between 1997 and 2015 at our university hospital. We categorized patients into two (RD, EGFR < 60 mL/min/1.73 m2; non-RD, EGFR ≥ 60 mL/min/1.73 m2) and three groups (severe CKD, EGFR < 30 mL/min/1.73 m2; mild CKD, 30 ≤ EGFR < 60 mL/min/1.73 m2; control, EGFR ≥ 60 mL/min/1.73 m2) according to renal function as defined by the EGFR. Overall survival (OS) and recurrence-free survival (RFS) were compared among these groups with the log-rank test, and we also analyzed survival by using a propensity score matching (PSM) model to exclude the influence of patient characteristics. The mean postoperative observation period was 64.7 ± 53.0 mo. RESULTS: The RD patients were significantly older and had lower serum total bilirubin, aspartate aminotransferase, and aspartate aminotransferase levels than the non-RD patients (P < 0.0001, P < 0.001, P < 0.05, and P < 0.01, respectively). No patient received maintenance hemodialysis after surgery. Although the overall postoperative complication rates were similar between the RD and non-RD patients, the proportions of postoperative bleeding and surgical site infection were significantly higher in the RD patients (5.5% vs 1.8%; P < 0.05, 3.9% vs 1.8%; P < 0.05, respectively), and postoperative bleeding was the highest in the severe CKD group (P < 0.05). Regardless of the degree of comorbid RD, OS and RFS were comparable, even after PSM between the RD and non-RD groups to exclude the influence of patient characteristics, liver function, and other causes of death. CONCLUSION: Comorbid mild RD had a negligible impact on the prognosis of HCC patients who underwent curative hepatectomy with appropriate perioperative management, and close attention to severe CKD is necessary to prevent postoperative bleeding and surgical site infection. - Liver metastasis 13 years after the resection of a malignant triton tumor originating in the duodenum
Keita Ohashi, Yoh Asahi, Toshiya Kamiyama, Tatsuhiko Kakisaka, Tatsuya Orimo, Akihisa Nagatsu, Yuzuru Sakamoto, Hirofumi Kamachi, Tomofumi Takagi, Takuya Otsuka, Tomoko Mitsuhashi, Shintaro Sugita, Tadashi Hasegawa, Akinobu Taketomi
International Cancer Conference Journal, 11, 3, 178, 183, Springer Science and Business Media LLC, Jul. 2022
Scientific journal - 経皮経肝門脈右枝塞栓後にcoronavirus disease 2019に罹患した盲腸癌肝転移の治癒的切除例
藤好 直, 柿坂 達彦, 松澤 文彦, 下國 達志, 木井 修平, 蔵谷 勇樹, 西川 眞, 森田 亮, 中西 勝也, 高木 智史, 高橋 昌宏
日本消化器外科学会雑誌, 55, 6, 389, 398, (一社)日本消化器外科学会, Jun. 2022
Japanese - A case of alveolar echinococcosis in the liver that ruptured into the pericardium treated by a combination of hepatectomy and albendazole.
Yoichi Yamamoto, Yuzuru Sakamoto, Toshiya Kamiyama, Akihisa Nagatsu, Yoh Asahi, Tatsuya Orimo, Tatsuhiko Kakisaka, Hirofumi Kamachi, Takuya Otsuka, Tomoko Mitsuhashi, Akinobu Taketomi
Surgical case reports, 8, 1, 63, 63, 08 Apr. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: Alveolar echinococcosis (AE) is a rare parasitic disease caused by the larva of Echinococcus multilocularis. It nearly always occurs in the liver, and cardiac involvement is extremely rare. Liver resection is the most effective intervention for AE because the only potentially curative treatment is removal of the lesion. Even when complete resection is not performed, long-term survival can be expected after surgical removal of most of the lesion with lifelong administration of albendazole (ABZ). CASE PRESENTATION: A 64-year-old man who lived in Hokkaido was referred to our hospital due to abnormalities in biliary enzymes. According to the findings from enhanced computed tomography and magnetic resource imaging of the abdomen, transthoracic echocardiography and serologic tests, he was diagnosed with hepatic AE with rupture into the pericardium. He underwent extended left hemi-hepatectomy with reconstruction of the inferior vena cava and opening of the pericardium with drainage as reduction surgery. Pathological examination revealed echinococcal infection in the pericardium as well as the liver. He started chemotherapy with 400 mg ABZ per Day 67 days after surgery. Although the surgical margin was positive in the pathological findings, he was alive 19 months later with no regrowth of the echinococcal lesion. CONCLUSION: AE with cardiac involvement is extremely rare. Even if the complete removal of cardiac-involved AE is not possible, surgical debulking with lifelong ABZ treatment can successfully manage the disease. - 分子標的薬時代後のBCLC stage C肝細胞癌の切除後成績の変化
旭 火華, 神山 俊哉, 柿坂 達彦, 折茂 達也, 長津 明久, 相山 健, 蒲池 浩文, 武冨 紹信
日本外科学会定期学術集会抄録集, 122回, SF, 5, (一社)日本外科学会, Apr. 2022
Japanese - Laparoscopic liver resection for liver metastasis of leiomyosarcoma of the thigh: a case report.
Shoichi Tsuzaka, Yoh Asahi, Toshiya Kamiyama, Tatsuhiko Kakisaka, Tatsuya Orimo, Akihisa Nagatsu, Takeshi Aiyama, Takeyuki Uebayashi, Hirofumi Kamachi, Masatake Matsuoka, Kento Wakabayashi, Takuya Otsuka, Yoshihiro Matsuno, Akinobu Taketomi
Surgical case reports, 8, 1, 47, 47, 21 Mar. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: Although there is no established treatment strategy for liver metastasis of leiomyosarcoma, liver resection has been reported to be effective in some cases. However, almost all liver resections performed for liver metastasis of primary leiomyosarcoma are reported to be open resections, and there are few reports of liver resection performed by laparoscopy. Here, we report a case of laparoscopic liver resection for liver metastasis of a leiomyosarcoma in the right thigh. CASE PRESENTATION: An 80-year-old man was diagnosed with leiomyosarcoma of the right thigh with liver metastasis. The primary tumor was first resected, and he was discharged on the 25th postoperative day. Four months after primary tumor resection, a laparoscopic right posterior sectionectomy was performed. There were no postoperative complications, and the patient was discharged on the 11th postoperative day with a histopathological diagnosis of liver metastasis of leiomyosarcoma and negative resection margins. Currently, 9 months have passed since the resection of the primary tumor, and 5 months have passed since the laparoscopic liver resection; there is no recurrence. CONCLUSIONS: The liver metastasis of leiomyosarcoma was successfully removed, with good short-term outcomes after the laparoscopic liver resection. Laparoscopic liver resection seems to be effective for liver metastasis of leiomyosarcoma, which is characterized by a high recurrence rate after surgery. However, more case studies may be necessary to examine the effectiveness and long-term results of laparoscopic liver resection for the treatment of liver metastasis of leiomyosarcoma. - 肝細胞癌患者の治癒切除後長期予後における腎機能障害の影響
坂本 譲, 神山 俊哉, 島田 慎吾, 相山 健, 旭 よう, 長津 明久, 折茂 達也, 柿坂 達彦, 蒲池 浩文, 武冨 紹信
日本臨床外科学会雑誌, 83, 3, 598, 599, 日本臨床外科学会, Mar. 2022
Japanese - Preventing Recurrence of Hepatocellular Carcinoma After Curative Hepatectomy With Active Hexose-correlated Compound Derived From Lentinula edodes Mycelia.
Toshiya Kamiyama, Tatsuya Orimo, Kenji Wakayama, Tatsuhiko Kakisaka, Shingo Shimada, Akihisa Nagatsu, Yoh Asahi, Takeshi Aiyama, Hirofumi Kamachi, Akinobu Taketomi
Integrative cancer therapies, 21, 15347354211073066, 15347354211073066, 2022, [International Magazine]
English, Scientific journal, PURPOSE: Active hexose-correlated compound (AHCC), a standardized extract of cultured Lentinula edodes mycelia, exerts antitumor effects through anti-inflammatory and immune-modulatory functions. Adjuvant therapy for patients with hepatocellular carcinoma (HCC) who have undergone curative hepatectomy has not been established. The purpose of this study was to evaluate the efficacy and safety of AHCC as adjuvant therapy in patients with advanced HCC after curative hepatectomy. PATIENTS AND METHODS: The study design was single-armed, non-randomized, open (no one was blinded), and uncontrolled. Patients with HCC who underwent curative hepatectomy were treated with AHCC (1 g) 3 times daily orally for 2 years. The inclusion criteria were HCC diagnosed preoperatively as stages A and B of the Barcelona clinic liver cancer (BCLC) classification and alpha-fetoprotein × protein induced by vitamin K absence or antagonist II (PIVKA-II) ≥ 105 for stage A. RESULTS: A total of 29 patients were treated with AHCC, of which 25 (4 patients discontinued) were followed up. The 2-year recurrence-free survival rate after resection was 48% for those without discontinuations and 55.2% for all patients with a history of treatment. Serum albumin levels decreased to a minimum in the first postoperative month and gradually recovered to the preoperative level at 6 months. Almost no change in lymphocyte percentage was observed during follow-up. Inflammation-based prognostic scores were maintained at favorable levels after hepatectomy. Toxicity and adverse events were not observed in any patient. CONCLUSION: AHCC may be safe and effective in preventing HCC recurrence after curative hepatectomy, and further randomized trials of AHCC for its use in this setting are warranted.This clinical trial was registered in UMIN Clinical Trials Registry (ID UMIN000024396). - 早期肝細胞癌に対する腹腔鏡下肝部分切除術の治療成績
旭 よう, 神山 俊哉, 柿坂 達彦, 折茂 達也, 長津 明久, 相山 健, 蒲池 浩文, 武冨 紹信
日本内視鏡外科学会雑誌, 26, 7, MO084, 6, (一社)日本内視鏡外科学会, Dec. 2021
Japanese - Outcomes of reduction hepatectomy combined with postoperative multidisciplinary therapy for advanced hepatocellular carcinoma.
Yoh Asahi, Toshiya Kamiyama, Tatsuhiko Kakisaka, Tatsuya Orimo, Shingo Shimada, Akihisa Nagatsu, Takeshi Aiyama, Yuzuru Sakamoto, Hirofumi Kamachi, Akinobu Taketomi
World journal of gastrointestinal surgery, 13, 10, 1245, 1257, 27 Oct. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: The prognosis of advanced hepatocellular carcinoma (HCC) that is not indicated for curative hepatectomy remains poor, despite advances in the treatment of HCC, including the development of tyrosine kinase inhibitors (TKIs). The outcomes of reduction hepatectomy and multidisciplinary postoperative treatment for advanced HCC that is not indicated for curative hepatectomy, including those of recently treated cases, should be investigated. AIM: To examine the outcomes of combination treatment with reduction hepatectomy and multidisciplinary postoperative treatment for advanced HCC that is not indicated for curative hepatectomy. METHODS: Thirty cases of advanced HCC that were not indicated for curative hepatectomy, in which reduction hepatectomy was performed between 2000 and 2018 at the Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, were divided into postoperative complete remission (POCR) (+) and POCR (-) groups, depending on whether POCR of all evaluable lesions was achieved through postoperative treatment. The cases in the POCR (-) group were subdivided into POCR (-) TKI (+) and POCR (-) TKI (-) groups, depending on whether TKIs were administered postoperatively. RESULTS: The 5-year overall survival rate and mean survival time (MST) after reduction hepatectomy were 15.7% and 28.40 mo, respectively, for all cases; 37.5% and 56.55 mo, respectively, in the POCR (+) group; and 6.3% and 14.84 mo, respectively, in the POCR (-) group (P = 0.0041). Tumor size, major vascular invasion, and the number of tumors in the remnant liver after the reduction hepatectomy were also found to be related to survival outcomes. The number of tumors in the remnant liver was the only factor that differed significantly between the POCR (+) and POCR (-) groups, and POCR was achieved significantly more frequently when ≤ 3 tumors remained in the remnant liver (P = 0.0025). The MST was 33.52 mo in the POCR (-) TKI (+) group, which was superior to the MST of 10.74 mo seen in the POCR (-) TKI (-) group (P = 0.0473). CONCLUSION: Reduction hepatectomy combined with multidisciplinary postoperative treatment for unresectable advanced HCC that was not indicated for curative hepatectomy was effective when POCR was achieved via multidisciplinary postoperative therapy. To achieve POCR, reduction hepatectomy should aim to ensure that ≤ 3 tumors remain in the remnant liver. Even in cases in which POCR is not achieved, combined treatment with reduction hepatectomy and multidisciplinary therapy can improve survival outcomes when TKIs are administered. - PTPE後に中等症COVID-19を罹患したが、呼吸状態改善後に治癒的切除をし得た転移性肝腫瘍の1例
藤好 直, 柿坂 達彦, 下國 達志, 松澤 文彦, 木井 修平, 蔵谷 勇樹, 西川 眞, 高橋 昌弘
日本臨床外科学会雑誌, 82, 増刊, S765, S765, 日本臨床外科学会, Oct. 2021
Japanese - 肝細胞癌に対する最新の集学的治療 術後再発肝細胞癌に対する分子標的薬使用の意義
旭 よう, 神山 俊哉, 折茂 達也, 柿坂 達彦, 長津 明久, 相山 健, 蒲池 浩文, 武冨 紹信
日本臨床外科学会雑誌, 82, 増刊, S280, S280, 日本臨床外科学会, Oct. 2021
Japanese - Combined treatment of an aortosplenic bypass followed by coil embolization in the treatment of pancreaticoduodenal artery aneurysms caused by median arcuate ligament compression: a report of two cases.
Shuhei Kii, Hirofumi Kamachi, Daisuke Abo, Takuya Kato, Yousuke Tsuruga, Kenji Wakayama, Tatsuhiko Kakisaka, Takeshi Soyama, Toshiya Kamiyama, Tomonori Ooka, Satoru Wakasa, Akinobu Taketomi
Surgical case reports, 7, 1, 174, 174, 04 Aug. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: Pancreaticoduodenal artery aneurysms (PDAAs) are rare visceral aneurysms, and prompt intervention/treatment of all PDAAs is recommended at the time of diagnosis to avoid rupture of aneurysms. Herein, we report two cases of PDAA caused by the median arcuate ligament syndrome, treated with surgical revascularization by aortosplenic bypass followed by coil embolization. CASE PRESENTATION: Case 1 A 54-year-old woman presented with a chief complaint of severe epigastralgia and was diagnosed with two large fusiform inferior PDAAs and celiac axis occlusion. To preserve the blood flow of the pancreatic head, duodenum, liver, and spleen, we performed elective surgery to release the MAL along with aortosplenic bypass. At 6 days postoperatively, transcatheter arterial embolization was performed. At the 8-year 6-month follow-up observation, no recurrent perfusion of the embolized PDAAs or rupture had occurred, including the non-embolized small PDAA, and the bypass graft had excellent patency. Case 2 A 39-year-old man who had been in good health was found to have a PDAA with celiac stenosis during a medical checkup. Computed tomography and superior mesenteric arteriography showed severe celiac axis stenosis and a markedly dilated pancreatic arcade with a large saccular PDAA. To preserve the blood flow of the pancreatic arcade, we performed elective surgery to release the MAL along with aortosplenic bypass. At 9 days postoperatively, transcatheter arterial embolization was performed. At the 6-year 7-month follow-up observation, no recurrent perfusion or rupture of the PDAA had occurred, and the bypass graft had excellent patency. CONCLUSION: Combined treatment with bypass surgery and coil embolization can be an effective option for the treatment of PDAAs associated with celiac axis occlusion or severe stenosis. - 高齢者に対する肝臓外科治療 後期高齢者における術前経皮経肝的門脈塞栓術の有用性の検討
坂本 譲, 神山 俊哉, 島田 慎吾, 旭 よう, 長津 明久, 折茂 達也, 柿坂 達彦, 蒲池 浩文, 武冨 紹信
日本消化器外科学会総会, 76回, PD5, 7, (一社)日本消化器外科学会, Jul. 2021
Japanese - BRA膵癌に対する治療戦略 BR膵癌に対するジェムシタビン併用術前化学放射線療法の成績
蒲池 浩文, 折茂 達也, 柿坂 達彦, 島田 慎吾, 長津 明久, 旭 よう, 坂本 譲, 神山 俊哉, 武冨 紹信
日本消化器外科学会総会, 76回, O34, 6, (一社)日本消化器外科学会, Jul. 2021
Japanese - 非大腸癌肝転移に対する肝切除の意義 悪性黒色腫肝転移に対する肝切除と免疫チェックポイント阻害剤の使用 3症例の検討
旭 よう, 神山 俊哉, 柿坂 達彦, 折茂 達也, 長津 明久, 坂本 譲, 蒲池 浩文, 武冨 紹信
日本消化器外科学会総会, 76回, RS18, 3, (一社)日本消化器外科学会, Jul. 2021
Japanese - Comparison of laparoscopic and open hepatectomy with synchronous colectomy for colorectal cancer with synchronous liver metastasis(和訳中)
Asahi Yoh, Kamiyama Toshiya, Kakisaka Tatsuhiko, Orimo Tatsuya, Nagatsu Akihisa, Sakamoto Yuzuru, Kamachi Hirofumi, Homma Shigenori, Ichikawa Nobuki, Yoshida Tadashi, Taketomi Akinobu
日本肝胆膵外科学会・学術集会プログラム・抄録集, 33回, 291, 291, (一社)日本肝胆膵外科学会, Jun. 2021
English - A case of laparoscopic hepatectomy for a primary hepatic neuroendocrine tumor.
Yuzuru Sakamoto, Shingo Shimada, Toshiya Kamiyama, Tatsuya Orimo, Akihisa Nagatsu, Yoh Asahi, Tatsuhiko Kakisaka, Hirofumi Kamachi, Tomoko Mitsuhashi, Akinobu Taketomi
Clinical journal of gastroenterology, 14, 3, 876, 880, Jun. 2021, [Domestic magazines]
English, Scientific journal, Neuroendocrine tumors (NETs) account for approximately 1-2% of all gastrointestinal tumors. In particular, primary hepatic NETs (PHNETs) are extremely rare. A 42-year-old female patient was given a diagnosis of liver tumor after a medical check-up with ultrasonography. An enhanced CT scan and MRI were suggestive for a hepatic hemangioma or adenoma, but the possibility of hepatocellular carcinoma could not be denied. Moreover, this tumor grew larger, so we performed a laparoscopic partial hepatectomy for the diagnosis and treatment of the patient. Pathological examination revealed that the tumor cells were spindle-shaped, forming glandular-tubular structures, and had less visible nucleoli and increased mitotic figures on H&E staining. Immunohistochemical findings indicated that CK19, MOC-31, CD56, synaptophysin, and chromogranin A were positive; CK7, AFP, and glypican-3 were negative; and the Ki-67 index was 3.6%, so the final diagnosis was a PHNET G2. PHNETs differ from other NETs, as they do not produce biologically active polypeptides or amines. As a result, there are no manifestations of carcinoid syndrome. In addition, PHNETs grow slowly, and most patients show no symptoms in the early stages. Laparoscopic hepatectomy is a very useful procedure for diagnosis and treatment in such cases and can be performed safely. - The impact of elastography with virtual touch quantification of future remnant liver before major hepatectomy.
Shingo Shimada, Toshiya Kamiyama, Tatsuhiko Kakisaka, Tatsuya Orimo, Akihisa Nagatsu, Yoh Asahi, Yuzuru Sakamoto, Hirofumi Kamachi, Yusuke Kudo, Mutsumi Nishida, Akinobu Taketomi
Quantitative imaging in medicine and surgery, 11, 6, 2572, 2585, Jun. 2021, [International Magazine]
English, Scientific journal, Background: Liver elastography with virtual touch quantification (VTQ) measures the velocity of the shear wave generated by a short-duration acoustic force impulse, with values expressed in units of velocity (m/s). VTQ can evaluate right or left hepatic lobes separately. VTQ might be appropriate for the evaluation of future remnant liver after hepatectomy. Methods: We analyzed 95 patients underwent liver elastography with VTQ and both future remnant liver and resected side before hepatectomy of more than two sections, except for central bisectionectomy. We divided the patients into a high VTQ group (≥1.52 m/s, n=37, 39%) and a low VTQ group (<1.52 m/s, n=58, 61%) according to the VTQ of future remnant liver. Transient elastography could not be performed in 22 cases due to tumor size. We defined the group with liver stiffness measurement (LSM) ≥7.9 kPa as the high LSM group (n=29, 40%) and those with LSM <7.9 kPa as the low LSM group (n=44, 60%). We investigated the outcome after hepatectomy and the correlations between the VTQ of future remnant liver and other indicators for hepatic fibrosis. Results: The high VTQ group showed significantly higher postoperative ascites (19% vs. 3%; P=0.01), pathological fibrosis (19% vs. 5%; P=0.03), and rates of patients with postoperative T-bil ≥2.0 mg/dL (70% vs. 40%; P<0.01). The high LSM group showed no significant postoperative outcomes compared to the low LSM group. The high VTQ group showed a higher frequency of male gender (78% vs. 57%; P=0.03), higher indocyanine green retention rate at 15 min (ICGR15) (10.5% vs. 6.3%; P<0.01), hyaluronic acid (100 vs. 67 ng/mL; P=0.02), type IV collagen 7S (7.6 vs. 5.1 ng/mL; P<0.01), Mac-2 binding protein glycan isomer (M2BPGi) (1.19 vs. 1.00; P=0.01), Fibrosis-4 (FIB-4) index (2.25 vs. 1.76; P=0.01), and aspartate aminotransferase to platelet ratio index (APRI) score (0.64 vs. 0.41; P<0.01). We also observed an especially strong positive correlation between the high VTQ and hyaluronic acid or type IV collagen 7S. Conclusions: Elastography with VTQ for future remnant liver before major hepatectomy is an accurate and useful method as a preoperative evaluation. - Genomewide transcriptomic profiling identifies a gene signature for predicting recurrence in early-stage hepatocellular carcinoma.
Tatsuhiko Kakisaka, Moto Fukai, Jasjit K Banwait, Toshiya Kamiyama, Tatsuya Orimo, Tomoko Mitsuhashi, Kensuke Yamamura, Takeo Toshima, Hideo Baba, Akinobu Taketomi, Ajay Goel
Clinical and translational medicine, 11, 6, e405, Jun. 2021, [International Magazine]
English - Treatment Outcomes of Stereotactic Body Radiation Therapy Using Real-time Tumor-tracking Radiotherapy System for Hepatocellular Carcinomas.
Yusuke Uchinami, Norio Katoh, Daisuke Abo, Hiroshi Taguchi, Koichi Yasuda, Kentaro Nishioka, Takeshi Soyama, Ryo Morita, Naoki Miyamoto, Ryusuke Suzuki, Takuya Sho, Masato Nakai, Koji Ogawa, Tatsuhiko Kakisaka, Tatsuya Orimo, Toshiya Kamiyama, Shinichi Shimizu, Hidefumi Aoyama
Hepatology research : the official journal of the Japan Society of Hepatology, 51, 8, 870, 879, 24 Apr. 2021, [International Magazine]
English, Scientific journal, AIM: To report the outcomes of stereotactic body radiotherapy (SBRT) using a real-time tumor-tracking radiotherapy (RTRT) system for hepatocellular carcinoma (HCC) patients. METHODS: From January 2005 to July 2018, 63 patients with 74 lesions with a maximum diameter ≤52 mm were treated by SBRT using the RTRT system. No patient with a Child-Pugh Score ≥9 was included and 85.6% had a score of 5 or 6. Using the biological effective dose (BED) with α/β ratio of 10 (BED10 ), the median dose in BED10 at the reference point was 76.8 Gy (range: 60-122.5). Overall survival (OS) and local control (LC) rates were assessed using the Kaplan-Meier method. RESULTS: With a median follow up period of 24.6 months (range: 0.9-118.4), the 1-year and 2-year OS rates were 86.8% (95% confidence interval [95% CI]; 75.8-93.3) and 71.1% (57.8-81.6), respectively. The 2-year OS was 89.6% in patients with the baseline modified albumin-bilirubin (mALBI) grade =1 and 61.7% in patients with grade ≥2a. In the multivariate analysis, the mALBI grade (=1 vs ≥2a) was a significant factor for OS (p=0.028, 95%CI: 1.11-6.18). The 1-year and 2-year LC rates were 100% (100-100) and 92.0% (77.5-97.5). The LC rates were significantly higher in the BED10 ≥100 Gy group than in the BED10 <100 Gy (2-year 100% vs 86.5%, p=0.049) at the reference point. CONCLUSION: This retrospective study of SBRT using RTRT for HCC showed favorable outcomes with lower incidence of toxicities, especially in patients treated with BED10 ≥100 Gy to the reference point. This article is protected by copyright. All rights reserved. - 肥満合併肝細胞癌患者における肝切除の検討
坂本 譲, 神山 俊哉, 島田 慎吾, 折茂 達也, 長津 明久, 旭 よう, 柿坂 達彦, 蒲池 浩文, 武冨 紹信
日本外科学会定期学術集会抄録集, 121回, PS, 8, (一社)日本外科学会, Apr. 2021
Japanese - 肝前区域切除術後に胆管狭窄に伴う肝後区域の萎縮を呈した2例
石川 倫啓, 柿坂 達彦, 坂本 譲, 旭 よう, 長津 明久, 島田 慎吾, 折茂 達也, 蒲池 浩文, 神山 俊哉, 武冨 紹信
日本外科学会定期学術集会抄録集, 121回, PS, 8, (一社)日本外科学会, Apr. 2021
Japanese - MicroRNAs in Colon Tissue of Pediatric Ulcerative Pancolitis Patients Allow Detection and Prognostic Stratification.
Petr Jabandziev, Tatsuhiko Kakisaka, Julia Bohosova, Tereza Pinkasova, Lumir Kunovsky, Ondrej Slaby, Ajay Goel
Journal of clinical medicine, 10, 6, 23 Mar. 2021, [International Magazine]
English, Scientific journal, Prevalence of inflammatory bowel disease has been on the rise in recent years, especially in pediatric populations. This study aimed to provide precise identification and stratification of pediatric patients with diagnosed ulcerative colitis (UC) according to the severity of their condition and the prediction for standard treatment according to the specific expression of candidate miRNAs. We enrolled consecutive, therapeutically naïve, pediatric UC patients with confirmed pancolitis. We examined formalin-fixed paraffin-embedded specimens of colonic tissue for the expression of 10 selected candidate miRNAs. We performed receiver operating characteristic curve analysis, using area under the curve and a logistic regression model to evaluate the diagnostic and predictive power of the miRNA panels. Sixty patients were included in the final analysis. As a control group, 18 children without macroscopic and microscopic signs of inflammatory bowel disease were examined. The combination of three candidate miRNAs (let-7i-5p, miR-223-3p and miR-4284) enabled accurate detection of pediatric UC patients and controls. A panel of four candidate miRNAs (miR-375-3p, miR-146a-5p, miR-223-3p and miR-200b-3p) was associated with severity of UC in pediatric patients and a combination of three miRNAs (miR-21-5p, miR-192-5p and miR-194-5p) was associated with early relapse of the disease. Nine patients out of the total were diagnosed with primary sclerosing cholangitis (PSC) simultaneously with ulcerative colitis. A panel of 6 candidate miRNAs (miR-142-3p, miR-146a-5p, miR-223-3p, let-7i-5p, miR-192-5p and miR-194-5p) identified those patients with PSC. Specific combinations of miRNAs are promising tools for potential use in precise disease identification and severity and prognostic stratification in pediatric patients with ulcerative pancolitis. - 悪性黒色腫の肝転移に対して肝切除を行った4症例の報告
旭 よう, 神山 俊哉, 柿坂 達彦, 折茂 達也, 長津 明久, 坂本 譲, 蒲池 浩文, 竹内 啓, 三橋 智子, 武冨 紹信
日本消化器病学会雑誌, 118, 臨増総会, A390, A390, (一財)日本消化器病学会, Mar. 2021
Japanese - Central Hepatectomy Versus Major Hepatectomy for Centrally Located Hepatocellular Carcinoma: A Propensity Score Matching Study.
Tatsuya Orimo, Toshiya Kamiyama, Tatsuhiko Kakisaka, Shingo Shimada, Akihisa Nagatsu, Yoh Asahi, Yuzuru Sakamoto, Hirofumi Kamachi, Akinobu Taketomi
Annals of surgical oncology, 28, 11, 6769, 6779, 01 Mar. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: In terms of anatomical liver sectionectomy approaches, both a central hepatectomy (CH) and major hepatectomy (MH) are feasible options for a centrally located hepatocellular carcinoma (HCC). METHODS: We retrospectively reviewed the surgical outcomes of central HCC patients who underwent CH or MH. MH includes hemihepatectomy or trisectionectomy, whereas CH involves a left medial sectionectomy, right anterior sectionectomy, or central bisectionectomy. The surgical outcomes were compared before and after propensity score matching (PSM). RESULTS: A total of 233 patients were enrolled, including 132 in the CH group and 101 in the MH group. The MH group cases were pathologically more advanced and had poorer overall survival rates than the CH group. After PSM, 68 patients were selected into each group, both of which showed similar overall and recurrence-free survival outcomes. The CH group showed a tendency for a longer operation time; however, other perioperative outcomes were similar between the two groups. Multivariate analyses of our matched HCC patients revealed that the type of surgery (CH or MH) was not an independent prognostic factor. More patients in the matched CH group experienced a repeat hepatectomy for recurrence and no patients in this group underwent a preoperative portal vein embolization. CONCLUSIONS: The short- and long-term surgical outcomes of CH and MH for a centrally located HCC are similar under a matched clinicopathological background. CH has the advantage of not requiring a preoperative portal vein embolization and increased chances of conducting a repeat hepatectomy for recurrence. - Functional transition: Inconsistently parallel to the increase in future liver remnant volume after preoperative portal vein embolization.
Yosuke Tsuruga, Toshiya Kamiyama, Hirofumi Kamachi, Tatsuya Orimo, Shingo Shimada, Akihisa Nagatsu, Yoh Asahi, Yuzuru Sakamoto, Tatsuhiko Kakisaka, Akinobu Taketomi
World journal of gastrointestinal surgery, 13, 2, 153, 163, 27 Feb. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: Preoperative portal vein embolization (PVE) is a widely used strategy to enable major hepatectomy in patients with insufficient liver remnant. PVE induces hypertrophy of the future liver remnant (FLR) and a shift of the functional reserve to the FLR. However, whether the increase of the FLR volume (FLRV) corresponds to the functional transition after PVE remains unclear. AIM: To investigate the sequential relationship between the increase in FLRV and functional transition after preoperative PVE using 3-dimensional (3D) computed tomography (CT) and 99mTc-galactosyl-human serum albumin (99mTc-GSA) single-photon emission computed tomography (SPECT) fusion images. METHODS: Thirty-three patients who underwent major hepatectomy following PVE at the Department of Gastroenterological Surgery I, Hokkaido University Hospital between October 2013 and March 2018 were enrolled. Three-phase dynamic multidetector CT and 99mTc-GSA SPECT scintigraphy were performed at pre-PVE, and at 1 and 2 wk after PVE; 3D 99mTc-GSA SPECT CT-fused images were constructed from the Digital Imaging and Communications in Medicine data using 3D image analysis system. Functional FLRV (FFLRV) was defined as the total liver volume × (FLR volume counts/total liver volume counts) on the 3D 99mTc-GSA SPECT CT-fused images. The calculated FFLRV was compared with FLRV. RESULTS: FFLRV increased by a significantly larger extent than FLRV at 1 and 2 wk after PVE (P < 0.01). The increase in FFLRV and FLRV was 55.1% ± 41.6% and 26.7% ± 17.8% (P < 0.001), respectively, at 1 wk after PVE, and 64.2% ± 33.3% and 36.8% ± 18.9% (P < 0.001), respectively, at 2 wk after PVE. In 3 of the 33 patients, FFLRV levels decreased below FLRV at 2 wk. One of the three patients showed rapidly progressive fatty changes in FLR. The biopsy at 4 wk after PVE showed macro- and micro-vesicular steatosis of more than 40%, which improved to 10%. Radical resection was performed at 13 wk after PVE. The patient recovered uneventfully without any symptoms of pos-toperative liver failure. CONCLUSION: The functional transition lagged behind the increase in FLRV after PVE in some cases. Evaluating both volume and function is needed to determine the optimal timing of hepatectomy after PVE. - Current role of intraoperative ultrasonography in hepatectomy.
Toshiya Kamiyama, Tatsuhiko Kakisaka, Tatsuya Orimo
Surgery today, 04 Jan. 2021, [Domestic magazines]
English, Scientific journal, Hepatectomy had a high mortality rate in the previous decade because of inadequate techniques, intraoperative blood loss, liver function reserve misdiagnoses, and accompanying postoperative complications. However, the development of several modalities, including intraoperative ultrasonography (IOUS), has made hepatectomy safer. IOUS can provide real-time information regarding the tumor position and vascular anatomy of the portal and hepatic veins. Systematic subsegmentectomy, which leads to improved patient outcomes, can be performed by IOUS in open and laparoscopic hepatectomy. Although three-dimensional (3D) computed tomography and gadoxetic acid-enhanced magnetic resonance imaging have been widely used, IOUS and contrast-enhanced IOUS are important modalities for risk analyses and making decisions regarding resectability and operative procedures because of the vital anatomical information provided and high sensitivity for liver tumors, including "disappearing" liver metastases. Intraoperative color Doppler ultrasonography can be used to delineate the vascular anatomy and evaluate the blood flow volume and velocity in hepatectomy patients and recipients of deceased- and living-donor liver transplantation after vessel reconstruction and liver positioning. For liver surgeons, IOUS is an essential technique to perform highly curative hepatectomy safely, although recent advances have also been made in virtual modalities, such as real-time virtual sonography with 3D visualization. - Early administration of anti-mesothelin antibody inhibits liver metastasis of pancreatic cancer in xenograft mouse model
Tatsuhiko Kakisaka
Cancer Science, 2021
Scientific journal - Impact of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging on the prognosis of hepatocellular carcinoma after surgery.
Shingo Shimada, Toshiya Kamiyama, Tatsuhiko Kakisaka, Tatsuya Orimo, Akihisa Nagatsu, Yoh Asahi, Yuzuru Sakamoto, Daisuke Abo, Hirofumi Kamachi, Akinobu Taketomi
JGH open : an open access journal of gastroenterology and hepatology, 5, 1, 41, 49, Jan. 2021, [International Magazine]
English, Scientific journal, Background and Aim: Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (EOB-MRI) has been recognized as a useful imaging technique to distinguish the biological behavior of hepatocellular carcinoma (HCC). Methods: We analyzed 217 hepatectomy recipients with HCCs measuring 10 cm or less. We divided the patients into a decreased intensity (DI) group (n = 189, 87%) and an increased or neutral intensity (INI) group (n = 28, 13%) according to the ratio of tumor intensity to liver intensity during the hepatobiliary phase (HBP). According to the ratio of the maximum tumor diameter (including peritumoral hypointensity) between HBP images and precontrast T1-weighted images (RHBPP), we divided the patients as follows: The group whose RHBPP was ≥1.036 was the high RHBPP group (n = 60, 28%), and the group whose RHBPP was <1.036 was the low RHBPP group (n = 157, 72%). We investigated the prognoses and clinicopathological characteristics of these patients. Results: DI versus INI was not a prognostic factor for either survival or recurrence; however, a high RHBPP was an independent predictor of unfavorable survival and recurrence in patients. In addition, the INI group showed significantly lower α-fetoprotein (AFP) levels and higher rates of well-differentiated HCC and ICGR15 ≥15% than the DI group. The high RHBPP group showed significantly higher rates of vascular invasion and poorly differentiated HCC than the low RHBPP group. Conclusions: A high RHBPP by EOB-MRI is a preoperative predictor of vascular invasion and an unfavorable prognostic factor for survival and recurrence. These patients might be considered for highly curative operations such as anatomical liver resection. - Analysis of the correlation between alterations in N‑glycans and invasiveness in liver cancer cell lines.
Hidenori Takahashi, Toshiya Kamiyama, Nozomi Hirane, Nozomi Kobayashi, Takeshi Aiyama, Akihisa Nagatsu, Shingo Shimada, Tatsuya Orimo, Tatsuhiko Kakisaka, Moto Fukai, Hideki Yokoo, Hirofumi Kamachi, Shin-Ichiro Nishimura, Akinobu Taketomi
Oncology reports, 44, 6, 2757, 2769, Dec. 2020, [International Magazine]
English, Scientific journal, The N‑glycoforms of glycoproteins modify protein function and control a number of biological pathways. The aim of the present study was to investigate the correlation between alterations in N‑glycans and cancer aggressiveness in terms of cancer cell invasion ability. The expression of urokinase‑type plasminogen activator (uPA) and N‑acetylglucosaminyltransferase V (GnT‑V) in liver cancer cell lines was analyzed by western blotting. Cell invasiveness was analyzed by Matrigel invasion assays. uPA and GnT‑V expression in liver cancer cell lines was knocked down by RNA interference. Furthermore, uPA was overexpressed in liver cancer cells using lentiviral vectors, and a mutant strain of HepG2 cells overexpressing uPA deficient in N‑glycans was established. A glycoblotting‑assisted matrix‑assisted laser desorption/ionization‑time‑of‑flight/mass spectrometry‑based quantitative analysis of liver cancer cell lines was performed, in which invasiveness was altered by modifying the expression of uPA and GnT‑V. N‑glycan profiles were found to differ between the highly invasive liver cancer cell line HLE and the less invasive cell line HepG2. The expression of several N‑glycans, including a form with m/z=1892, was changed according to invasiveness controlled by knockdown and overexpression of uPA. The invasiveness of HepG2 cells with mutant uPA did not increase regardless of the level of expression of uPA. Following GnT‑V knockdown and N‑glycan alteration, uPA expression did not change, whereas cell invasiveness decreased. One N‑glycan (m/z=1892) was common among N‑glycans in the comparative analysis between HLE and HepG2, HLE and uPA knockdown HLE, HepG2 and uPA‑overexpressing HepG2, and HLE and GnT‑V knockdown HLE cells and among N‑glycan profiles in human uPA. Therefore, N‑glycosylation is an important factor controlling invasiveness of liver cancer cells, and a specific N‑glycan (m/z=1892) associated with the invasion of liver cancer cells via uPA was identified in the present study. - Xenograftマウスモデルを用いた抗メソテリン抗体の早期投与による膵癌肝転移抑制効果の検討
藤居 勇貴, 蒲池 浩文, 深井 原, 折茂 達也, 坂本 譲, 旭 よう, 長津 明久, 島田 慎吾, 柿坂 達彦, 神山 俊哉, 武冨 紹信
日本癌学会総会記事, 79回, OJ14, 4, (一社)日本癌学会, Oct. 2020
English - 肝切除を施行後集学的治療にて長期生存が得られているG-CSF産生肝細胞癌の1例
坂本 譲, 神山 俊哉, 旭 よう, 長津 明久, 島田 慎吾, 折茂 達也, 柿坂 達彦, 蒲池 浩文, 武冨 紹信
日本癌治療学会学術集会抄録集, 58回, P, 190, (一社)日本癌治療学会, Oct. 2020
Japanese - CD133 and epithelial cell adhesion molecule expressions in the cholangiocarcinoma component are prognostic factors for combined hepatocellular cholangiocarcinoma.
Kazuki Wakizaka, Hideki Yokoo, Toshiya Kamiyama, Tatsuhiko Kakisaka, Masafumi Ohira, Michio Tani, Koichi Kato, Yuki Fujii, Ko Sugiyama, Akihisa Nagatsu, Shingo Shimada, Tatsuya Orimo, Hirofumi Kamachi, Ryosuke Matsuoka, Akinobu Taketomi
Hepatology research : the official journal of the Japan Society of Hepatology, 50, 2, 258, 267, Feb. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, AIM: A new classification of combined hepatocellular cholangiocarcinoma (CHC) was recently reported. Cancer stem cells have been associated with CHC carcinogenesis. This study examined the association of cancer stem cell marker expression and prognosis in CHC classified using the new classification. METHODS: We enrolled 26 CHC patients and classified them according to the new classification. We evaluated the expression of cancer stem cell markers (CD56, CD133, and epithelial cell adhesion molecule [EpCAM]) by immunohistochemical staining in each component. We analyzed the association between expressions and prognosis. RESULTS: Seven cases were hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) (cHCC-CCA), 12 were HCC and intermediate cell carcinoma (HCC-INT), and seven were intermediate cell carcinoma (INT). The CD133-positive rate tended to be higher in the CCA (42.9%) and INT component (50.0%) than the HCC component (14.3%) in cHCC-CCA. In HCC-INT, the CD133-positive rate in the INT component (83.3%) was significantly higher than the HCC component (8.3%; P = 0.001). For EpCAM, the positive rate in the CCA component (71.4%) and INT component (50.0%) tended to be higher than the HCC component (14.3%) in cHCC-CCA. Overall survival and disease-free survival were significantly worse in cases with CD133-positive (P = 0.048 and P = 0.048, respectively) or EpCAM-positive (P = 0.041 and P = 0.041, respectively) CCA component in cHCC-CCA. CONCLUSIONS: INT and CCA components showed higher expression rates of cancer stem cell markers than the HCC component. CD133 or EpCAM expression in the CCA component was associated with poor prognosis in cHCC-CCA. - GENOMEWIDE TRANSCRIPTOMIC PROFILING IDENTIFIES A NOVEL GENE SIGNATURE FOR PREDICTING EXTRAHEPATIC METASTASIS FOLLOWING SURGERY IN HEPATOCELLULAR CARCINOMA
Tatsuhiko Kakisaka
Gastroenterology, 2020
Scientific journal - Uncovering Potential Therapeutic Targets in Colorectal Cancer by Deciphering Mutational Status and Expression of Druggable Oncogenes.
Otília Menyhart, Tatsuhiko Kakisaka, Lőrinc Sándor Pongor, Hiroyuki Uetake, Ajay Goel, Balázs Győrffy
Cancers, 11, 7, 14 Jul. 2019, [International Magazine]
English, Scientific journal, BACKGROUND: Numerous driver mutations have been identified in colorectal cancer (CRC), but their relevance to the development of targeted therapies remains elusive. The secondary effects of pathogenic driver mutations on downstream signaling pathways offer a potential approach for the identification of therapeutic targets. We aimed to identify differentially expressed genes as potential drug targets linked to driver mutations. METHODS: Somatic mutations and the gene expression data of 582 CRC patients were utilized, incorporating the mutational status of 39,916 and the expression levels of 20,500 genes. To uncover candidate targets, the expression levels of various genes in wild-type and mutant cases for the most frequent disruptive mutations were compared with a Mann-Whitney test. A survival analysis was performed in 2100 patients with transcriptomic gene expression data. Up-regulated genes associated with worse survival were filtered for potentially actionable targets. The most significant hits were validated in an independent set of 171 CRC patients. RESULTS: Altogether, 426 disruptive mutation-associated upregulated genes were identified. Among these, 95 were linked to worse recurrence-free survival (RFS). Based on the druggability filter, 37 potentially actionable targets were revealed. We selected seven genes and validated their expression in 171 patient specimens. The best independently validated combinations were DUSP4 (p = 2.6 × 10-12) in ACVR2A mutated (7.7%) patients; BMP4 (p = 1.6 × 10-04) in SOX9 mutated (8.1%) patients; TRIB2 (p = 1.35 × 10-14) in ACVR2A mutated patients; VSIG4 (p = 2.6 × 10-05) in ANK3 mutated (7.6%) patients, and DUSP4 (p = 7.1 × 10-04) in AMER1 mutated (8.2%) patients. CONCLUSIONS: The results uncovered potentially druggable genes in colorectal cancer. The identified mutations could enable future patient stratification for targeted therapy. - Hepatic hypertrophy and hemodynamics of portal venous flow after percutaneous transhepatic portal embolization.
Shingo Shimada, Toshiya Kamiyama, Hideki Yokoo, Tatsuya Orimo, Kenji Wakayama, Akihisa Nagatsu, Tatsuhiko Kakisaka, Hirofumi Kamachi, Daisuke Abo, Yusuke Sakuhara, Akinobu Taketomi
BMC surgery, 19, 1, 23, 23, 18 Feb. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Percutaneous transhepatic portal embolization (PTPE) is useful for safe major hepatectomy. This study investigated the correlation between hepatic hypertrophy and hemodynamics of portal venous flow by ultrasound sonography after PTPE. METHODS: We analyzed 58 patients with PTPE, excluding those who underwent recanalization (n = 10). Using CT volumetry results 2 weeks after PTPE, the patients were stratified into a considerable hypertrophy group (CH; n = 15) with an increase rate of remnant liver volume (IR-RLV) ≥ 40% and a minimal hypertrophy group (MH; n = 33) with an IR-RLV < 40%. We investigated the hemodynamics of portal venous flow after PTPE and the favorable factors for hepatic hypertrophy. RESULTS: Univariate and multivariate analysis identified the indocyanine green retention rate at 15 min (ICGR15) and increase rate of portal venous flow volume (IR-pFV) at the non-embolized lobe on day 3 after PTPE as independent favorable factors of IR-RLV. Patients with IR-pFV on day 3 after PTPE ≥100% and ICGR15 ≤ 15% (n = 13) exhibited significantly increased IR-RLV compared with others (n = 35). CONCLUSIONS: Cases with high IR-pFV on day 3 after PTPE exhibited better hepatic hypertrophy. Preserved liver function and increased portal venous flow on day 3 were important. - A NOVEL GENE EXPRESSION SIGNATURE FOR PREDICTING EARLIER RECURRENCE IN EARLY-STAGE HEPATOCELLULAR CARCINOMA PATIENTS UNDERGOING SURGICAL RESECTION
Tatsuhiko Kakisaka
Gastroenterology, 2019
Scientific journal - Transparenchymal glissonean approach: a novel surgical technique for advanced perihilar bile duct cancer
Hirofumi Kamachi, Toshiya Kamiyama, Yousuke Tsuruga, Tatsuya Orimo, Kenji Wakayama, Shingo Shimada, Tatsuhiko Kakisaka, Hideki Yokoo, Kenichiro Yamashita, Akinobu Taketomi
Langenbeck's Archives of Surgery, 403, 3, 387, 394, Springer Verlag, 01 May 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal - Hepatectomy for hepatocellular carcinoma with portal vein tumor thrombus
Toshiya Kamiyama, Tatsuhiko Kakisaka, Tatsuya Orimo, Kenji Wakayama
World Journal of Hepatology, 9, 36, 1296, 1304, Baishideng Publishing Group Co, 28 Dec. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal - Clinicopathological Characteristics of Hepatocellular Carcinoma with Microscopic Portal Venous Invasion and the Role of Anatomical Liver Resection in These Cases
Shingo Shimada, Toshiya Kamiyama, Hideki Yokoo, Tatsuya Orimo, Kenji Wakayama, Takahiro Einama, Tatsuhiko Kakisaka, Hirofumi Kamachi, Akinobu Taketomi
WORLD JOURNAL OF SURGERY, 41, 8, 2087, 2094, Aug. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal - Hepatectomy for liver metastasis from gastrointestinal stromal tumor in the era of imatinib mesylate: a case series study.
Kawamura N, Kamiyama T, Yokoo H, Kakisaka T, Orimo T, Wakayama K, Tsuruga Y, Kamachi H, Hatanaka K, Taketomi A
International cancer conference journal, 6, 3, 121, 125, Jul. 2017, [Peer-reviewed], [International Magazine]
English, The prognosis of metastatic gastrointestinal stromal tumor (GIST) has improved since the introduction of imatinib mesylate; however, acquired resistance has been reported, so alternative treatment option is needed. We evaluated the efficacy of hepatectomy for metastatic GIST. Six patients with liver metastases from GIST underwent hepatectomy. Four were treated with imatinib mesylate before hepatectomy, and all the patients were treated with imatinib mesylate after hepatectomy. Patients were followed-up for a mean duration of 113.5 months after hepatectomy. Complete resection was accomplished in four patients, with incomplete resection performed in the remaining two patients due to peritoneal dissemination. One patient with incomplete resection died 10 months after surgery. One patient with complete resection has survived without disease progression since initial hepatectomy. The remaining four patients with progressive disease during imatinib mesylate treatment developed tumor recurrence and three of them underwent a second hepatectomy. These three patients underwent complete resection during repeat surgery. In total, three patients died during the follow-up period, all of whom had tumors of small intestine origin. Primary tumor site (small intestine vs. others) was identified as a risk factor of mortality (P = 0.02). Although not statistically significant, there was a trend toward better outcomes in patients with exon 11 mutations. Surgical resection for metastatic GIST was shown to be effective and needed to achieve a better prognosis. Repeat hepatectomy demonstrated efficacy in selected patients. Hepatectomy should be considered based on tumor characteristics such as primary tumor site and c-KIT mutation status. - Fatty acid-binding protein 5 function in hepatocellular carcinoma through induction of epithelial-mesenchymal transition.
Takanori Ohata, Hideki Yokoo, Toshiya Kamiyama, Moto Fukai, Takeshi Aiyama, Yutaka Hatanaka, Kanako Hatanaka, Kenji Wakayama, Tatsuya Orimo, Tatsuhiko Kakisaka, Nozomi Kobayashi, Yoshihiro Matsuno, Akinobu Taketomi
Cancer medicine, 6, 5, 1049, 1061, Apr. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, Hepatocellular carcinoma (HCC) is a highly prevalent cancer with poor prognosis. The correlation between overexpression of fatty acid-binding protein 5 (FABP5) and malignant potential of tumor growth and metastasis in several cancers has been previously reported. However, the correlation between FABP5 expression and HCC malignant behavior remains unknown. We compared FABP5 expression and patient characteristics in paired HCC and adjacent noncancerous liver tissues from 243 patients who underwent surgical resection of primary HCC. Cell proliferation, invasion, and migration assays were performed in HCC cell lines overexpressing FABP5 or downregulated for FABP5. Tumor growths were monitored in xenograft model, and liver and lung metastasis models were established. In the 243 HCC patients, FABP5-positive staining (n = 139/243, 57.2%) was associated with poor prognosis and recurrence (P < 0.0001) and showed positive correlation with distant metastasis, tumor size and vascular invasion (P < 0.05). Cell proliferation, invasion, and migration in vitro were enhanced by upregulation of FABP5 and decreased by downregulation of FABP5 in HCC cell lines. Similar results in tumor formation and metastasis were obtained through in vivo analyses. PCR array results revealed upregulation of SNAI1 in FABP5-overexpressing HepG2 cells. Western blot analysis showed significantly increased expression of E-cadherin and ZO-1 and decreased SNAI1 expression and nuclear translocation of β-catenin by knockdown of FABP5. We revealed a significant role for FABP5 in HCC progression and metastasis through the induction of epithelial-to-mesenchymal transition. FABP5 may be a potential novel prognostic biomarker and new therapeutic target for HCC. - [Analysis of Oxaliplatin Combination Therapy for Unresectable or Recurrent Gastric Cancer].
Yoshinori Oikawa, Masahiro Takahashi, Shusaku Takahashi, Satoru Matsumoto, Sachiko Kenno, Keita Noguchi, Tatsuhiko Kakisaka, Munenori Tahara, Hideki Yamagami, Hiroyuki Ishizu
Gan to kagaku ryoho. Cancer & chemotherapy, 43, 12, 1579, 1581, Nov. 2016, [Domestic magazines]
Japanese, Scientific journal, We analyzed 26 cases of unresectable or recurrent gastric cancer treated with oxaliplatin(OX)combination therapy between September 2014 and January 2016. The number of unresectable gastric cancer cases was 14 and there were 12 recurrent cases. The number of patients receiving S-1 plus OX(SOX), SOX plus trastuzumab(Tmab), capecitabine(Cape)plus OX(CapeOX), and CapeOX plus Tmab was 17, 1, 6, and 2, respectively. The starting dose of OX was 130mg/m2 in 12 patients and 100mg/m2 in 14. The median follow-up duration from the first treatment was 6 months(1-14). The median number of treatment cycles was 5(1-19). Dose reductions occurred in 14 cases, and treatment delay occurred in 13 cases. Grade 3 adverse events occurred in 2 cases(8%); thrombocytopenia and stomatitis occurred in 1 case. The response rate was 23%, the disease control rate was 69%, and the median relapse-free survival time was 4 months(1-14). OX combination therapy for unresectable or recurrent gastric cancer was feasible in terms of safety and might be effective for disease control. - Our technique of preceding diaphragm resection and partial mobilization of the hepatic right lobe using a vessel sealing device (LigaSure™) for huge hepatic tumors with diaphragm invasion
Kenji Wakayama, Toshiya Kamiyama, Hideki Yokoo, Tatsuhiko Kakisaka, Tatsuya Orimo, Shingo Shimada, Yosuke Tsuruga, Hirofumi Kamachi, Akinobu Taketomi
Surgery Today, 46, 10, 1224, 1229, Springer Tokyo, 01 Oct. 2016, [Peer-reviewed], [Domestic magazines]
English, Scientific journal - ZEB1 expression is associated with prognosis of intrahepatic cholangiocarcinoma
Katsumi Terashita, Makoto Chuma, Yutaka Hatanaka, Kanako Hatanaka, Tomoko Mitsuhashi, Hideki Yokoo, Takumi Ohmura, Hiroyuki Ishizu, Shunji Muraoka, Atsushi Nagasaka, Takahiro Tsuji, Yoshiya Yamamoto, Nobuaki Kurauchi, Norihiko Shimoyama, Hidenori Toyoda, Takashi Kumada, Yuji Kaneoka, Atsuyuki Maeda, Koji Ogawa, Mitsuteru Natsuizaka, Hirofumi Kamachi, Tatsuhiko Kakisaka, Toshiya Kamiyama, Akinobu Taketomi, Yoshihiro Matsuno, Naoya Sakamoto
Journal of Clinical Pathology, 69, 7, 593, 599, BMJ Publishing Group, 01 Jul. 2016, [Peer-reviewed], [International Magazine]
English, Scientific journal - Significance of functional hepatic resection rate calculated using 3D CT/99mTc-galactosyl human serum albumin singlephoton emission computed tomography fusion imaging
Yosuke Tsuruga, Toshiya Kamiyama, Hirofumi Kamachi, Shingo Shimada, Kenji Wakayama, Tatsuya Orimo, Tatsuhiko Kakisaka, Hideki Yokoo, Akinobu Taketomi
World Journal of Gastroenterology, 22, 17, 4373, 4379, Baishideng Publishing Group Co., Limited, 07 May 2016, [Peer-reviewed], [International Magazine]
English, Scientific journal - Resection of liver metastasis derived from alpha-fetoprotein-producing gastric cancer-report of 4 cases
Asahi Yoh, Kamiyama Toshiya, Homma Shigenori, Hatanaka Kanako C, Yokoo Hideki, Nakagawa Takahito, Kamachi Hirofumi, Nakanishi Kazuaki, Tahara Munenori, Kakisaka Tatsuhiko, Wakayama Kenji, Todo Satoru, Taketomi Akinobu
INTERNATIONAL CANCER CONFERENCE JOURNAL, 5, 2, 98, 103, Apr. 2016, [Peer-reviewed], [International Magazine]
English - Anatomical hepatectomy using indocyanine green fluorescent imaging and needle- guiding technique
Toshiya Kamiyama, Tatsuhiko Kakisaka, Hideki Yokoo, Tatsuya Orimo, Kenji Wakayama, Hirofumi Kamachi, Yosuke Tsuruga, Akinobu Taketomi
ICG Fluorescence Imaging and Navigation Surgery, 305, 313, Springer Japan, 01 Jan. 2016, [Peer-reviewed]
English, In book - Models predicting the risks of six life-threatening morbidities and bile leakage in 14,970 hepatectomy patients registered in the National Clinical Database of Japan
Hideki Yokoo, Hiroaki Miyata, Hiroyuki Konno, Akinobu Taketomi, Tatsuhiko Kakisaka, Norimichi Hirahara, Go Wakabayashi, Mitsukazu Gotoh, Masaki Mori
Medicine (United States), 95, 49, e5466, Lippincott Williams and Wilkins, 2016, [Peer-reviewed], [International Magazine]
English, Scientific journal - [Efficacy of Sorafenib for Extrahepatic Recurrence of Hepatocellular Carcinoma after Liver Resection].
Yokoo H, Kamiyama T, Kakisaka T, Orimo T, Wakayama K, Shimada S, Tsuruga Y, Kamachi H, Taketomi A
Gan to kagaku ryoho. Cancer & chemotherapy, 42, 12, 1497, 1499, Nov. 2015, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, Sorafenib is the first molecularly targeted drug recommended as a treatment for advanced hepatocellular carcinoma (HCC). Herein, we report the efficacy of sorafenib for extrahepatic recurrence of HCC. From September 2004 to March 2015, 47 patients who were diagnosed with recurrent HCC after liver resection were treated with sorafenib. The overall response rate was 17.5% (complete response: CR 1, partial response: PR 6, stable disease: SD 17, progressive disease: PD 13, SD beyond PD 3), and the disease control rate was 67.5%. The median time to disease progression, including extrahepatic recurrence, was significantly better than in the group with only intrahepatic metastasis (p=0.034). Therefore, sorafenib might be an effective treatment for extrahepatic recurrence of HCC. - [Effect of Preoperative Bowel Preparation on Surgical Site Infection in Liver Surgery].
Orimo T, Kamiyama T, Yokoo H, Kakisaka T, Wakayama K, Tsuruga Y, Kamachi H, Taketomi A
Gan to kagaku ryoho. Cancer & chemotherapy, 42, 12, 1887, 1889, (株)癌と化学療法社, Nov. 2015, [Peer-reviewed], [Domestic magazines]
Japanese - Multiplication of alpha-fetoprotein and protein induced by vitamin K absence-II is a powerful predictor of prognosis and recurrence in hepatocellular carcinoma patients after a hepatectomy
Toshiya Kamiyama, Hideki Yokoo, Tatsuhiko Kakisaka, Tatsuya Orimo, Kenji Wakayama, Hirofumi Kamachi, Yosuke Tsuruga, Kenichiro Yamashita, Tsuyoshi Shimamura, Satoru Todo, Akinobu Taketomi
HEPATOLOGY RESEARCH, 45, 10, E21, E31, Oct. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal - Intratumoral artery on contrast-enhanced computed tomography imaging: differentiating intrahepatic cholangiocarcinoma from poorly differentiated hepatocellular carcinoma
Seiji Tsunematsu, Makoto Chuma, Toshiya Kamiyama, Noriyuki Miyamoto, Satoshi Yabusaki, Kanako Hatanaka, Tomoko Mitsuhashi, Hirofumi Kamachi, Hideki Yokoo, Tatsuhiko Kakisaka, Yousuke Tsuruga, Tatsuya Orimo, Kenji Wakayama, Jun Ito, Fumiyuki Sato, Katsumi Terashita, Masato Nakai, Yoko Tsukuda, Takuya Sho, Goki Suda, Kenichi Morikawa, Mitsuteru Natsuizaka, Mitsuru Nakanishi, Koji Ogawa, Akinobu Taketomi, Yoshihiro Matsuno, Naoya Sakamoto
ABDOMINAL IMAGING, 40, 6, 1492, 1499, Aug. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal - 膵癌術前放射線化学療法における術前胆道ドレナージ法の検討
敦賀 陽介, 蒲池 浩文, 若山 顕治, 折茂 達也, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 武冨 紹信
日本肝胆膵外科学会・学術集会プログラム・抄録集, 27回, 626, 626, (一社)日本肝胆膵外科学会, Jun. 2015
Japanese - Intra-arterial infusion of IA-call® combined with oral anticancer drugs for recurrent hepatocellular carcinoma after liver resection
Kenji Wakayama, Toshiya Kamiyama, Hideki Yokoo, Tatsuhiko Kakisaka, Tatsuya Orimo, Yosuke Tsuruga, Hirofumi Kamachi, Takeshi Soyama, Yusuke Sakuhara, Daisuke Abo, Akinobu Taketomi
Japanese Journal of Cancer and Chemotherapy, 41, 12, 1503, 1505, Japanese Journal of Cancer and Chemotherapy Publishers Inc., 01 Nov. 2014, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal - 巨大肝細胞癌手術症例の治療成績
柿坂 達彦, 神山 俊哉, 横尾 英樹, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
Japanese Journal of Acute Care Surgery, 4, 2, 304, 304, 日本Acute Care Surgery学会, Sep. 2014
Japanese - Hand-assisted laparoscopic splenectomy for sclerosing angiomatoid nodular transformation of the spleen complicated by chronic disseminated intravascular coagulation: A case report
Tatsuhiko Kakisaka, Toshiya Kamiyama, Hideki Yokoo, Tatsuya Orimo, Kenji Wakayama, Yosuke Tsuruga, Hirofumi Kamachi, Taisuke Harada, Fumi Kato, Yosuke Yamada, Tomoko Mitsuhashi, Akinobu Taketomi
Asian Journal of Endoscopic Surgery, 7, 3, 275, 278, Wiley, Aug. 2014, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, A 36-year-old man who presented with a nosebleed and anemia was referred to our hospital. Laboratory test results showed platelet depletion, decreased levels of fibrinogen, and increased fibrinogen degeneration products. CT showed a 13-cm splenic tumor. T2 -weighted MRI revealed a high-intensity mass. We preoperatively diagnosed splenic hemangioma with chronic disseminated intravascular coagulation and scheduled an operation to relieve the disseminated intravascular coagulation. We also performed hand-assisted laparoscopic splenectomy to ensure easy handling of the splenomegaly. The resected specimen microscopically consisted of hemorrhages and hemangiomatous lesions, and multiple angiomatoid nodules were scattered and separated by fibrocollagenous stroma with inflammatory cells. Three types of vessels (capillaries, sinusoids and small veins) were contained in the angiomatoid nodules, and the pathological diagnosis was sclerosing angiomatoid nodular transformation. The results of this case suggest that we should consider sclerosing angiomatoid nodular transformation in the differential diagnosis of patients with splenic tumors, as sclerosing angiomatoid nodular transformation with hemangiomatous features may cause coagulation disorders for which splenectomy should be performed. - ICG蛍光法とニードルガイディングテクニックを併用した肝亜区域切除術
折茂 達也, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本消化器外科学会総会, 69回, RV, 1, (一社)日本消化器外科学会, Jul. 2014
Japanese - 99mTc-GSAシンチグラフィーとCTの3D fusion画像を用いた残肝機能予測
敦賀 陽介, 蒲池 浩文, 若山 顕治, 折茂 達也, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 武冨 紹信
日本消化器外科学会総会, 69回, O, 5, (一社)日本消化器外科学会, Jul. 2014
Japanese - 肝切除術におけるリスク評価と治療成績向上に向けた対策 NCDデータに基づいた肝切除術におけるリスク評価
武冨 紹信, 宮田 裕章, 柿坂 達彦, 横尾 英樹, 友滝 愛, 今野 弘之, 後藤 満一, 若林 剛, 森 正樹, 一般社団法人日本消化器外科学会データベース委員会
日本消化器外科学会総会, 69回, PD, 1, (一社)日本消化器外科学会, Jul. 2014
Japanese - 肝切除術におけるリスク評価と治療成績向上に向けた対策 99mTc-GSAシンチグラフィを用いた肝障害度別換算ICGR15による肝予備能の評価
若山 顕治, 神山 俊哉, 柿坂 達彦, 折茂 達也, 横尾 英樹, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本消化器外科学会総会, 69回, PD, 5, (一社)日本消化器外科学会, Jul. 2014
Japanese - HBV関連肝細胞癌手術症例の術後再発に関する検討
柿坂 達彦, 神山 俊哉, 横尾 英樹, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本消化器外科学会総会, 69回, P, 3, (一社)日本消化器外科学会, Jul. 2014
Japanese - 肝細胞癌における門脈侵襲・予後・再発予測因子としての腫瘍マーカー AFPとPIVKA-IIの積=AP-factorの検討
神山 俊哉, 横尾 英樹, 柿坂 達彦, 折茂 達也, 若山 顕治, 蒲池 浩文, 敦賀 陽介, 武冨 紹信
日本消化器外科学会総会, 69回, P, 6, (一社)日本消化器外科学会, Jul. 2014
Japanese - 大腸癌多発肝転移に対する外科切除のタイミング
横尾 英樹, 神山 俊哉, 柿坂 達彦, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本消化器外科学会総会, 69回, O, 2, (一社)日本消化器外科学会, Jul. 2014
Japanese - 血管合併切除を要する局所進行肝門部胆管癌における血管確保手技
蒲池 浩文, 敦賀 陽介, 若山 顕示, 折茂 達也, 柿坂 達彦, 横尾 英樹, 山下 健一郎, 神山 俊哉, 武冨 紹信
日本消化器外科学会総会, 69回, O, 1, (一社)日本消化器外科学会, Jul. 2014
Japanese - 浸潤性膵管癌の術前治療 当科における局所進行膵癌に対する術前放射線化学療法の検討
蒲池 浩文, 敦賀 陽介, 若山 顕治, 折茂 達也, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 武冨 紹信
日本肝胆膵外科学会・学術集会プログラム・抄録集, 26回, 387, 387, (一社)日本肝胆膵外科学会, Jun. 2014
Japanese - 肝右葉巨大肝癌に対する、ベッセルシーリングシステムを用いた右横隔膜切除、肝右葉受動先行右系肝葉切除
若山 顕治, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 折茂 達也, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本肝胆膵外科学会・学術集会プログラム・抄録集, 26回, 448, 448, (一社)日本肝胆膵外科学会, Jun. 2014
Japanese - 99mTc-GSAシンチグラフィーとCTの3D fusion画像を用いた機能的肝切除率の算出
敦賀 陽介, 蒲池 浩文, 若山 顕治, 折茂 達也, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 武冨 紹信
日本肝胆膵外科学会・学術集会プログラム・抄録集, 26回, 484, 484, (一社)日本肝胆膵外科学会, Jun. 2014
Japanese - 多発性大腸癌肝転移の治療方針
横尾 英樹, 神山 俊哉, 柿坂 達彦, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本肝胆膵外科学会・学術集会プログラム・抄録集, 26回, 549, 549, (一社)日本肝胆膵外科学会, Jun. 2014
Japanese - 人工血管を用いた肝切除症例の検討
折茂 達也, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本肝胆膵外科学会・学術集会プログラム・抄録集, 26回, 588, 588, (一社)日本肝胆膵外科学会, Jun. 2014
Japanese - 肝エキノコックス症に対する腹腔鏡下肝切除術
柿坂 達彦, 神山 俊哉, 横尾 英樹, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本肝胆膵外科学会・学術集会プログラム・抄録集, 26回, 686, 686, (一社)日本肝胆膵外科学会, Jun. 2014
Japanese - 当科における肝細胞癌に対する腹腔鏡下肝切除術の成績
柿坂 達彦, 神山 俊哉, 横尾 英樹, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本癌治療学会誌, 49, 3, 1669, 1669, (一社)日本癌治療学会, Jun. 2014
Japanese - 横行結腸癌肝転移切除後断端再発に対し施行したRFA後に、biloma内再発をきたした1例
深作 慶友, 神山 俊哉, 若山 顕治, 折茂 達也, 敦賀 陽介, 柿坂 達彦, 横尾 英樹, 蒲池 浩文, 武富 紹信
北海道外科雑誌, 59, 1, 62, 62, 北海道外科学会, Jun. 2014
Japanese - A pilot study for cellular detection of circulating tumor cells and disseminated tumor cells of patients with hepatocellular carcinoma.
Nozomi Minagawa, Hideyasu Sakihama, Nozomi Kobayashi, Mito Obara, Susumu Shibasaki, Kenji Wakayama, Tatsuya Orimo, Tatsuhiko Kakisaka, Yousuke Tsuruga, Shigenori Homma, Hideki Yokoo, Hirofumi Kamachi, Hideki Kawamura, Norihiko Takahashi, Toshiya Kamiyama, Akinobu Taketomi
JOURNAL OF CLINICAL ONCOLOGY, 32, 15, May 2014, [Peer-reviewed]
English - Usefulness of artificial vascular graft for venous reconstruction in liver surgery
Tatsuya Orimo, Toshiya Kamiyama, Hideki Yokoo, Tatsuhiko Kakisaka, Kenji Wakayama, Yosuke Tsuruga, Hirofumi Kamachi, Akinobu Taketomi
WORLD JOURNAL OF SURGICAL ONCOLOGY, 12, 113, 113, Apr. 2014, [Peer-reviewed], [International Magazine]
English, Scientific journal - Long-Term Outcome of Laparoscopic Hepatectomy in Patients with Hepatocellular Carcinoma
Toshiya Kamiyama, Munenori Tahara, Kazuaki Nakanishi, Hideki Yokoo, Hirofumi Kamachi, Tatsuhiko Kakisaka, Yosuke Tsuruga, Michiaki Matsushita, Satoru Todo
HEPATO-GASTROENTEROLOGY, 61, 130, 405, 409, Mar. 2014, [Peer-reviewed]
English, Scientific journal - 人工血管による肝静脈再建を伴う肝切除術を施行した肝細胞癌の2例
折茂 達也, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
北海道外科雑誌, 58, 2, 181, 181, 北海道外科学会, Dec. 2013
Japanese - 肝原発腺扁平上皮癌の1例
宮岡 陽一, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 畑中 佳奈子
北海道外科雑誌, 58, 2, 182, 183, 北海道外科学会, Dec. 2013
Japanese - 当科における胆管癌再発症例の検討
敦賀 陽介, 蒲池 浩文, 若山 顕治, 折茂 達也, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 武冨 紹信
北海道外科雑誌, 58, 2, 184, 184, 北海道外科学会, Dec. 2013
Japanese - [Long-term survival of a patient with metachronous lymph node metastasis and bile duct tumor thrombus due to hepatocellular carcinoma successfully treated with repeated surgery].
Kakisaka T, Kamiyama T, Yokoo H, Orimo T, Wakayama K, Tsuruga Y, Kamachi H, Hatanaka K, Taketomi A
Gan to kagaku ryoho. Cancer & chemotherapy, 40, 12, 1831, 1833, 12, Nov. 2013, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, A 64-year-old man with hepatocellular carcinoma located in the left lateral lobe and segment 5 was referred to our hospital for surgical treatment. We performed left lateral sectionectomy and segmentectomy 5. The pathological diagnosis was moderately to poorly differentiated hepatocellular carcinoma, and the pathological stage was stage III. Eight months later, intrahepatic recurrence in segment 1 and lymph node metastasis in the hepatoduodenal ligament occurred. Partial resection of segment 1 was performed, and the metastatic lymph node was surgically removed. Twenty four months after the first operation, lymph node metastases along the lesser curvature and retropancreatic space were extirpated. Lymph node metastases along the common hepatic artery were removed 76 months after the first operation. The patient developed jaundice 88 months after the initial surgery, and the bile duct tumor thrombus derived from intrahepatic recurrence in segment 1 caused obstructive jaundice. After percutaneous transhepatic biliary drainage, we performed median sectionectomy and bile duct tumor thrombus removal without bile duct resection. At his 8-year follow-up visit after the primary operation, the patient was healthy and did not show any signs of recurrence. Lymph node metastasis and bile duct tumor thrombus are rare patterns of hepatocellular carcinoma recurrence, and aggressive surgery can result in long-term survival when complete resection is anticipated. - Surgical management of hepatocellular carcinoma with tumor thrombi in the inferior vena cava or right atrium
Kenji Wakayama, Toshiya Kamiyama, Hideki Yokoo, Tatsuhiko Kakisaka, Hirofumi Kamachi, Yosuke Tsuruga, Kazuaki Nakanishi, Tsuyoshi Shimamura, Satoru Todo, Akinobu Taketomi
World Journal of Surgical Oncology, 11, 259, 259, 05 Oct. 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal - 断端陽性となった肝門部胆管癌に対する術後放射線療法の意義
蒲池 浩文, 敦賀 陽介, 若山 顕治, 折茂 達也, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 武冨 紹信
日本臨床外科学会雑誌, 74, 増刊, 617, 617, 日本臨床外科学会, Oct. 2013
Japanese - 肝細胞癌肺転移切除後19年間無再発の一例
相山 健, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武富 紹信
日本癌治療学会誌, 48, 3, 2409, 2409, (一社)日本癌治療学会, Sep. 2013
Japanese - 肝細胞癌における予後再発因子としてのFABP5の有用性
大畑 多嘉宣, 横尾 英樹, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 神山 俊哉, 武冨 紹信
日本消化器外科学会総会, 68回, P, 8, (一社)日本消化器外科学会, Jul. 2013
Japanese - 肝尾状葉腫瘍切除における3D画像によるシミュレーションの有用性
若山 顕治, 神山 俊哉, 柿坂 達彦, 横尾 英樹, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本消化器外科学会総会, 68回, O, 3, (一社)日本消化器外科学会, Jul. 2013
Japanese - 左葉系切除を要する高度進行胆道癌に対するTransparenchymal glissonean approachを用いた血行再建法
蒲池 浩文, 敦賀 陽介, 若山 顕治, 柿坂 達彦, 横尾 英樹, 山下 健一郎, 神山 俊哉, 武冨 紹信
日本消化器外科学会総会, 68回, RV, 3, (一社)日本消化器外科学会, Jul. 2013
Japanese - 血清中糖鎖の網羅的解析による肝細胞癌新規バイオマーカーの開発
神山 俊哉, 柿坂 達彦, 横尾 英樹, 蒲池 浩文, 若山 顕治, 敦賀 陽介, 三浦 信明, 西村 紳一郎, 藤堂 省, 武冨 紹信
日本消化器外科学会総会, 68回, O, 5, (一社)日本消化器外科学会, Jul. 2013
Japanese - Identification of novel serum biomarkers of hepatocellular carcinoma using glycomic analysis
Toshiya Kamiyama, Hideki Yokoo, Jun-Ichi Furukawa, Masaki Kurogochi, Tomoaki Togashi, Nobuaki Miura, Kazuaki Nakanishi, Hirofumi Kamachi, Tatsuhiko Kakisaka, Yosuke Tsuruga, Masato Fujiyoshi, Akinobu Taketomi, Shin-Ichiro Nishimura, Satoru Todo
HEPATOLOGY, 57, 6, 2314, 2325, Jun. 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal - An intraductal papillary neoplasm of the bile duct mimicking a hemorrhagic hepatic cyst: a case report
Tatsuhiko Kakisaka, Toshiya Kamiyama, Hideki Yokoo, Kazuaki Nakanishi, Kenji Wakayama, Yosuke Tsuruga, Hirofumi Kamachi, Tomoko Mitsuhashi, Akinobu Taketomi
WORLD JOURNAL OF SURGICAL ONCOLOGY, 11, 111, 111, May 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal - A pilot study for cellular detection of circulating tumor cells and disseminated tumor cells of patients with hepatocellular carcinoma.
Nozomi Minagawa, Hideyasu Sakihama, Nozomi Kobayashi, Kenji Wakayama, Tatsuhiko Kakisaka, Yousuke Tsuruga, Tatsushi Shimokuni, Shigenori Homma, Hideki Yokoo, Hirofumi Kamachi, Norihiko Takahashi, Toshiya Kamiyama, Akinobu Taketomi
JOURNAL OF CLINICAL ONCOLOGY, 31, 15, May 2013, [Peer-reviewed]
English - Portal vein stenosis after pancreatectomy following neoadjuvant chemoradiation therapy for pancreatic cancer
Yosuke Tsuruga, Hirofumi Kamachi, Kenji Wakayama, Tatsuhiko Kakisaka, Hideki Yokoo, Toshiya Kamiyama, Akinobu Taketomi
WORLD JOURNAL OF GASTROENTEROLOGY, 19, 16, 2569, 2573, Apr. 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal - Clinicopathological characteristics and prognostic factors in young patients after hepatectomy for hepatocellular carcinoma
Shingo Shimada, Toshiya Kamiyama, Hideki Yokoo, Kenji Wakayama, Yosuke Tsuruga, Tatsuhiko Kakisaka, Hirofumi Kamachi, Akinobu Taketomi
WORLD JOURNAL OF SURGICAL ONCOLOGY, 11, 52, 52, Mar. 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal - 胆道癌手術に有用な外科解剖と画像診断 肝門部領域胆道系腫瘍に対する胆管・血管3DCT合成画像の治療戦略上の位置づけ
蒲池 浩文, 敦賀 陽介, 若山 顕治, 柿坂 達彦, 横尾 英樹, 山下 健一郎, 神山 俊哉, 武冨 紹信
日本外科学会雑誌, 114, 臨増2, 146, 146, (一社)日本外科学会, Mar. 2013
Japanese - 腹腔鏡下肝切除の現状と適応拡大の試み 適応拡大を目指した腹腔鏡下肝切除における肝門部処理・肝実質切離法の確立
神山 俊哉, 横尾 英樹, 柿坂 達彦, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本外科学会雑誌, 114, 臨増2, 201, 201, (一社)日本外科学会, Mar. 2013
Japanese - 肝静脈解剖に注目した肝切除 3D画像支援システムによる下右肝静脈還流領域を評価した肝切除
横尾 英樹, 神山 俊哉, 柿坂 達彦, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本外科学会雑誌, 114, 臨増2, 211, 211, (一社)日本外科学会, Mar. 2013
Japanese - 肝エキノコッカス症と鑑別困難であったMulticystic billary hamartomaの一例
本間 友樹, 武冨 紹信, 神山 俊哉, 蒲池 浩文, 横尾 英樹, 柿坂 達彦, 敦賀 陽介, 若山 顕治
日本臨床外科学会雑誌, 74, 2, 595, 595, 日本臨床外科学会, Feb. 2013
Japanese - Utility of Fatty Acid Binding Protein 5 expression as a recurrence and prognostic factor in hepatocellular carcinoma
Tatsuhiko Kakisaka
Hepatology, 2013
Scientific journal - 大腸癌肝転移に対するRFA後再発の2例
石黒 友唯, 中西 一彰, 横尾 英樹, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 神山 俊哉
IVR: Interventional Radiology, 27, 4, 457, 458, (一社)日本インターベンショナルラジオロジー学会, Nov. 2012
Japanese - Liver hanging maneuverとその応用 肝門部胆管癌におけるLiver hanging maneuverを応用した肝実質切離
蒲池 浩文, 敦賀 陽介, 若山 顕治, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 武冨 紹信
日本臨床外科学会雑誌, 73, 増刊, 379, 379, 日本臨床外科学会, Oct. 2012
Japanese - 肝尾状葉腫瘍切除における3次元画像解析システムの有用性
若山 顕治, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 蒲池 浩文, 敦賀 陽介, 武富 紹信
日本臨床外科学会雑誌, 73, 増刊, 694, 694, 日本臨床外科学会, Oct. 2012
Japanese - 血管合併切除を伴う術前放射線化学療法施行後膵癌根治切除症例の検討
敦賀 陽介, 蒲池 浩文, 若山 顕治, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 武富 紹信
日本臨床外科学会雑誌, 73, 増刊, 767, 767, 日本臨床外科学会, Oct. 2012
Japanese - 当科における胆道嚢胞性疾患症例の検討
敦賀 陽介, 蒲池 浩文, 柿坂 達彦, 横尾 英樹, 中西 一彰, 神山 俊哉, 武冨 紹信
日本消化器外科学会総会, 67回, 2, 2, (一社)日本消化器外科学会, Jul. 2012
Japanese - 予後、再発因子からみた肝内胆管癌の治療戦略
横尾 英樹, 神山 俊哉, 中西 一彰, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本消化器外科学会総会, 67回, 1, 1, (一社)日本消化器外科学会, Jul. 2012
Japanese - 腹腔鏡下・補助下肝切除術における肝実質切離の工夫と定型化
神山 俊哉, 中西 一彰, 横尾 英樹, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本消化器外科学会総会, 67回, 1, 1, (一社)日本消化器外科学会, Jul. 2012
Japanese - 肝細胞癌遠隔転移切除症例の検討
中西 一彰, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本消化器外科学会総会, 67回, 2, 2, (一社)日本消化器外科学会, Jul. 2012
Japanese - 肝門部領域胆道系腫瘍における胆管・血管3DCT合成画像を用いた手術シミュレーション
蒲池 浩文, 敦賀 陽介, 柿坂 達彦, 横尾 英樹, 中西 一彰, 神山 俊哉, 武冨 紹信
日本消化器外科学会総会, 67回, 1, 1, (一社)日本消化器外科学会, Jul. 2012
Japanese - 超高齢者の肝細胞癌手術症例に関する検討
柿坂 達彦, 神山 俊哉, 中西 一彰, 横尾 英樹, 蒲池 浩文, 敦賀 陽介, 武冨 紹信
日本消化器外科学会総会, 67回, 1, 1, (一社)日本消化器外科学会, Jul. 2012
Japanese - Analysis of the risk factors for early death due to disease recurrence or progression within 1 year after hepatectomy in patients with hepatocellular carcinoma
Toshiya Kamiyama, Kazuaki Nakanishi, Hideki Yokoo, Hirofumi Kamachi, Munenori Tahara, Tatsuhiko Kakisaka, Yosuke Tsuruga, Satoru Todo, Akinobu Taketomi
WORLD JOURNAL OF SURGICAL ONCOLOGY, 10, 107, 107, Jun. 2012, [Peer-reviewed], [International Magazine]
English, Scientific journal - 後腹膜巨大脂肪肉腫の一切除例
豊島 雄二郎, 中西 一彰, 横尾 英樹, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 松下 通明, 神山 俊哉
日本臨床外科学会雑誌, 73, 6, 1599, 1599, 日本臨床外科学会, Jun. 2012
Japanese - 減量手術の肝エキノコックス症に対しアルベンダゾールが著効した1例
梅本 浩平, 横尾 英樹, 中西 一彰, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 佐藤 直樹, 神山 俊哉
日本臨床外科学会雑誌, 73, 6, 1602, 1602, 日本臨床外科学会, Jun. 2012
Japanese - 膵・胆管合流異常を伴う先天性胆道拡張症に対する分流手術後に発生した胆管癌の1例
岡田 尚樹, 蒲池 浩文, 敦賀 陽介, 柿坂 達彦, 横尾 英樹, 中西 一彰, 松下 通明, 神山 俊哉
日本臨床外科学会雑誌, 73, 6, 1604, 1604, 日本臨床外科学会, Jun. 2012
Japanese - 胆管空腸吻合術後の肝内結石症に対する肝切除術の検討
敦賀 陽介, 蒲池 浩文, 柿坂 達彦, 横尾 英樹, 中西 一彰, 神山 俊哉, 武冨 紹信
北海道外科雑誌, 57, 1, 74, 74, 北海道外科学会, Jun. 2012
Japanese - HBs抗原陰性・HCV抗体陰性肝細胞癌切除例の検討
中西 一彰, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
北海道外科雑誌, 57, 1, 74, 75, 北海道外科学会, Jun. 2012
Japanese - 成人肝未分化肉腫の1例
鈴木 智亮, 神山 俊哉, 中西 一彰, 横尾 英樹, 柿坂 達彦, 敦賀 陽介, 鈴木 崇史, 蒲池 浩文, 松下 通明, 武冨 紹信
北海道外科雑誌, 57, 1, 75, 75, 北海道外科学会, Jun. 2012
Japanese - 術後胆管狭窄に対する皮下埋め込み式胆道内瘻術の有用性
川俣 太, 神山 俊哉, 中西 一彰, 横尾 英樹, 柿坂 達彦, 田原 宗徳, 蒲池 浩文, 松下 通明, 藤堂 省
日本消化器外科学会雑誌, 45, 6, 615, 622, (一社)日本消化器外科学会, Jun. 2012
Japanese - 肝胆膵領域の外科治療 これまでの到達点、これからの課題 肝細胞癌に対する肝切除術 系統的切除か部分切除か 小型肝細胞癌に対する系統的肝切除術の術後長期成績の検討
武冨 紹信, 神山 俊哉, 中西 一彰, 蒲池 浩文, 横尾 英樹, 柿坂 達彦, 敦賀 陽介
日本肝胆膵外科学会・学術集会プログラム・抄録集, 24回, 195, 195, (一社)日本肝胆膵外科学会, May 2012
Japanese - 局所進行肝内胆管癌に対してR0をめざした下大静脈合併切除グラフト再建
横尾 英樹, 神山 俊哉, 中西 一彰, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本肝胆膵外科学会・学術集会プログラム・抄録集, 24回, 302, 302, (一社)日本肝胆膵外科学会, May 2012
Japanese - 再発形式からみた胆管癌治療戦略
敦賀 陽介, 蒲池 浩文, 柿坂 達彦, 横尾 英樹, 中西 一彰, 神山 俊哉, 武冨 紹信
日本肝胆膵外科学会・学術集会プログラム・抄録集, 24回, 420, 420, (一社)日本肝胆膵外科学会, May 2012
Japanese - 血管合併切除を伴う肝門部領域胆道系癌に対する手術アプローチ
蒲池 浩文, 敦賀 陽介, 柿坂 達彦, 横尾 英樹, 中西 一彰, 神山 俊哉, 武冨 紹信
日本肝胆膵外科学会・学術集会プログラム・抄録集, 24回, 420, 420, (一社)日本肝胆膵外科学会, May 2012
Japanese - 出血性肝嚢胞と鑑別を要した胆管内乳頭状腫瘍(IPNB)の1例
柿坂 達彦, 中西 一彰, 横尾 英樹, 蒲池 浩文, 敦賀 陽介, 神山 俊哉, 武冨 紹信
日本肝胆膵外科学会・学術集会プログラム・抄録集, 24回, 431, 431, (一社)日本肝胆膵外科学会, May 2012
Japanese - A long-term survival case of adult undifferentiated embryonal sarcoma of liver
Keita Noguchi, Hideki Yokoo, Kazuaki Nakanishi, Tatsuhiko Kakisaka, Yosuke Tsuruga, Hirofumi Kamachi, Michiaki Matsushita, Toshiya Kamiyama
WORLD JOURNAL OF SURGICAL ONCOLOGY, 10, 65, 65, Apr. 2012, [Peer-reviewed], [International Magazine]
English, Scientific journal - 血行性転移予防を念頭においた肝細胞癌術後補助化学療法の検討
中西 一彰, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
肝臓, 53, Suppl.1, A393, A393, (一社)日本肝臓学会, Apr. 2012
Japanese - Oncologic emergencyとしての下大静脈・右心房浸潤肝細胞癌に対する外科治療
中西 一彰, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 武冨 紹信
日本腹部救急医学会雑誌, 32, 2, 408, 408, (一社)日本腹部救急医学会, Feb. 2012
Japanese - 再肝切除におけるICG蛍光法の使用経験
川俣 太, 神山 俊哉, 横尾 英樹, 蒲池 浩文, 田原 宗徳, 柿坂 達彦, 中西 一彰, 松下 通明, 藤堂 省
IVR: Interventional Radiology, 27, 1, 73, 73, (一社)日本インターベンショナルラジオロジー学会, Feb. 2012
Japanese - Role of percutaneous transhepatic biliary endoprostheses with distal tube implantation in the subcutaneous space for management of patients with postoperative biliary stricture
Futoshi Kawamata, Toshiya Kamiyama, Kazuaki Nakanishi, Hideki Yokoo, Tatsuhiko Kakisaka, Munenori Tahara, Hirofumi Kamachi, Michiaki Matsusita, Satoru Todo
Japanese Journal of Gastroenterological Surgery, 45, 6, 615, 622, 2012, [Peer-reviewed]
Japanese, Scientific journal - 原発性肝癌に対する無水エタノールを用いた術前門脈塞栓術の検討
柿坂 達彦, 中西 一彰, 横尾 英樹, 敦賀 陽介, 蒲池 浩文, 松下 通明, 神山 俊哉
北海道外科雑誌, 56, 2, 152, 152, 北海道外科学会, Dec. 2011
Japanese - 門脈内腫瘍栓を形成した膵管癌の2切除例
敦賀 陽介, 蒲池 浩文, 柿坂 達彦, 横尾 英樹, 中西 一彰, 松下 通明, 神山 俊哉
北海道外科雑誌, 56, 2, 155, 155, 北海道外科学会, Dec. 2011
Japanese - 著明な壁肥厚を呈した劇症型アメーバ性大腸炎の1例
柿坂 達彦, 相木 総良, 松久 忠史, 服部 淳夫, 古家 乾, 数井 啓蔵
北海道外科雑誌, 56, 2, 134, 138, 北海道外科学会, Dec. 2011
Japanese - [Usefulness of intraoperative fluorescent imaging using indocyanine green for repeated resection of hepatocellular carcinoma].
Yokoo H, Nakanishi K, Kakisaka T, Tsuruga Y, Kawamata F, Kamachi H, Matsushita M, Kamiyama T
Gan to kagaku ryoho. Cancer & chemotherapy, 38, 12, 2481, 2483, 12, Nov. 2011, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, For recurrent hepatic tumors with treatment history or cirrhosis, small region including extrahepatic tumors that cannot be identified on routine ultrasonography, we used a fluorescent imaging with indocyanine green (ICG) for repeated resection of hepatocellular carcinoma. The patients were consisted of 4 men and 2 women with a mean age of 61.5 (37-66) years. Five cases of intra or extra hepatic tumors could be identified with fluorescent imaging system. Two cases were a local recurrence after TACE, 1 case was a small tumor exited in liver surface, 1 case could be identified the area of vascular invasion of subcutaneous recurrence, and 1 case was a mediastinal small lymph node metastasis of hepatocellular carcinoma. Fluorescent imaging using ICG was considered to be useful for identification of recurrent hepatocellular carcinoma that cannot be identified by a routine ultrasonography. - 術前の血清検査で診断が困難であった肝エキノコックス症の1例
松澤 文彦, 神山 俊哉, 中西 一彰, 横尾 英樹, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 松下 通明, 佐藤 直樹
日本臨床外科学会雑誌, 72, 10, 2739, 2740, 日本臨床外科学会, Oct. 2011
Japanese - 進行肝細胞癌の治療戦略 高度脈管侵襲陽性肝細胞癌に対する治療戦略
中西 一彰, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 松下 通明
日本臨床外科学会雑誌, 72, 増刊, 328, 328, 日本臨床外科学会, Oct. 2011
Japanese - 手術・そこが知りたい!(肝・胆・膵領域の手術における血行再建術) SMA周囲神経叢郭清に先行して門脈再建を行う膵頭十二指腸切除
蒲池 浩文, 敦賀 陽介, 柿坂 達彦, 横尾 英樹, 中西 一彰, 松下 通明, 神山 俊哉
日本臨床外科学会雑誌, 72, 増刊, 407, 407, 日本臨床外科学会, Oct. 2011
Japanese - 長期生存を得た成人肝未分化肉腫の1例
野口 慶太, 横尾 英樹, 中西 一彰, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 松下 通明, 神山 俊哉
日本臨床外科学会雑誌, 72, 増刊, 620, 620, 日本臨床外科学会, Oct. 2011
Japanese - vp2肝細胞癌の治療成績と今後の展望
横尾 英樹, 神山 俊哉, 中西 一彰, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 松下 通明
日本臨床外科学会雑誌, 72, 増刊, 621, 621, 日本臨床外科学会, Oct. 2011
Japanese - 再肝切除に伴うICG蛍光法の有用性
川俣 太, 神山 俊哉, 横尾 英樹, 中西 一彰, 柿坂 達彦, 敦賀 陽介, 田原 宗徳, 蒲池 浩文, 松下 通明, 藤堂 省
日本臨床外科学会雑誌, 72, 増刊, 622, 622, 日本臨床外科学会, Oct. 2011
Japanese - Coombs陰性自己免疫性溶血性貧血に対し、腹腔鏡下脾臓摘出術が奏功した1例
松澤 文彦, 神山 俊哉, 中西 一彰, 蒲池 浩文, 横尾 英樹, 敦賀 陽介, 柿坂 達彦, 松下 通明
日本臨床外科学会雑誌, 72, 増刊, 814, 814, 日本臨床外科学会, Oct. 2011
Japanese - 肝エキノコックス症に対する腹腔鏡下肝切除術
柿坂 達彦, 中西 一彰, 横尾 英樹, 蒲池 浩文, 敦賀 陽介, 松下 通明, 佐藤 直樹, 神山 俊哉
日本臨床外科学会雑誌, 72, 増刊, 819, 819, 日本臨床外科学会, Oct. 2011
Japanese - 膵・胆道癌術後門脈狭窄に対し、門脈ステントを留置した3例
敦賀 陽介, 蒲池 浩文, 柿坂 達彦, 横尾 英樹, 中西 一彰, 松下 通明, 神山 俊哉
日本臨床外科学会雑誌, 72, 増刊, 829, 829, 日本臨床外科学会, Oct. 2011
Japanese - Local skin flap reconstruction for abdominal wound dehiscence after abdominal surgery with a stoma: report of two cases.
Tatsuhiko Kakisaka, Shigehito Yoneyama, Tomonari Katayama, Takeshi Kikuchi, Kazuhito Uemura, Yoshio Ito, Yoshie Une
Surgery today, 41, 9, 1252, 4, Sep. 2011, [Domestic magazines]
English, Scientific journal, Abdominal wound dehiscence is a serious complication of laparotomy, and fascial dehiscence in a patient with a stoma is especially difficult to manage. We describe how we performed local skin flap reconstruction for abdominal wound dehiscence in two patients with stomas. One patient underwent sigmoidectomy with a colostomy for peritonitis caused by perforated diverticulitis of the sigmoid colon. Postoperative fascial dehiscence was repaired by rhomboid flap reconstruction. The other patient underwent total gastrectomy, cholecystectomy, and splenectomy. An ileostomy was performed for digestive tract perforation, which was complicated by abdominal dehiscence with necrosis of the fascia. This was repaired by rotation flap reconstruction. The abdominal walls in both patients were repaired successfully without tension. - ミリプラチンを用いたLipiodol-TAI後早期に血流が再開した再発HCC2例
松澤 文彦, 神山 俊哉, 中西 一彰, 横尾 英樹, 柿坂 達彦, 田原 宗徳, 谷口 雅彦, 蒲池 浩文, 松下 通明, 藤堂 省, 作原 祐介, 曽山 武志
IVR: Interventional Radiology, 26, 3, 341, 341, (一社)日本インターベンショナルラジオロジー学会, Aug. 2011
Japanese - 高度脈管侵襲を伴う肝細胞癌に対する治療戦略 Vp3、4肝細胞癌における術前門脈腫瘍栓に対する放射線照射の有用性
神山 俊哉, 中西 一彰, 横尾 英樹, 蒲池 浩文, 田原 宗徳, 柿坂 達彦, 松下 通明, 藤堂 省
日本消化器外科学会総会, 66回, 200, 200, (一社)日本消化器外科学会, Jul. 2011
Japanese - 術前肝予備能評価の再考 当科の術前肝予備能評価と肝2区域切除以上の180例の検討(適応拡大に向けた新しい評価方法)
田原 宗徳, 神山 俊哉, 柿坂 達彦, 横尾 英樹, 蒲池 浩文, 中西 一彰, 松下 通明, 藤堂 省
日本消化器外科学会総会, 66回, 257, 257, (一社)日本消化器外科学会, Jul. 2011
Japanese - 肝胆道癌手術における肝臓外科と胆道外科の接点 左葉系切除を要する肝門部胆管系腫瘍における肝実質切離による右グリソンアプローチ
蒲池 浩文, 神山 俊哉, 田原 宗徳, 柿坂 達彦, 横尾 英樹, 中西 一彰, 山下 健一郎, 松下 通明, 藤堂 省
日本消化器外科学会総会, 66回, 285, 285, (一社)日本消化器外科学会, Jul. 2011
Japanese - 下大静脈・右心房に進展した肝細胞癌(Vv3)に対する切除治療成績の検討
中西 一彰, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 田原 宗徳, 蒲池 浩文, 松下 通明, 藤堂 省
日本消化器外科学会総会, 66回, 443, 443, (一社)日本消化器外科学会, Jul. 2011
Japanese - 大腸癌肝転移切除後の治療戦略 再切除可能な術後補助化学療法をめざして
横尾 英樹, 神山 俊哉, 中西 一彰, 柿坂 達彦, 田原 宗徳, 蒲池 浩文, 松下 通明, 藤堂 省
日本消化器外科学会総会, 66回, 557, 557, (一社)日本消化器外科学会, Jul. 2011
Japanese - 肝エキノコックス症に対する肝切除成績の検討
川村 典生, 神山 俊哉, 佐藤 直樹, 中西 一彰, 横尾 英樹, 柿坂 達彦, 蒲池 浩文, 田原 宗徳, 松下 通明, 藤堂 省
日本消化器外科学会総会, 66回, 643, 643, (一社)日本消化器外科学会, Jul. 2011
Japanese - 若年者肝細胞癌切除症例における予後因子の検討
島田 慎吾, 神山 俊哉, 中西 一彰, 横尾 英樹, 蒲池 浩文, 田原 宗徳, 柿坂 達彦, 松下 通明, 藤堂 省
日本消化器外科学会総会, 66回, 646, 646, (一社)日本消化器外科学会, Jul. 2011
Japanese - 大腸癌肝転移切除例の治療成績
横尾 英樹, 神山 俊哉, 中西 一彰, 柿坂 達彦, 田原 宗徳, 小丹枝 裕二, 相山 健, 蒲池 浩文, 松下 通明, 藤堂 省
北海道外科雑誌, 56, 1, 59, 59, 北海道外科学会, Jun. 2011
Japanese - 大腸穿通により診断に苦慮した肝エキノコックス症の一例
相山 健, 神山 俊哉, 中西 一彰, 蒲池 浩文, 横尾 英樹, 田原 宗徳, 柿坂 達彦, 松下 通明, 藤堂 省
北海道外科雑誌, 56, 1, 60, 60, 北海道外科学会, Jun. 2011
Japanese - 腹腔内原発のキャッスルマン病の一例
川俣 太, 蒲池 浩文, 田原 宗徳, 柿坂 達彦, 横尾 英樹, 中西 一彰, 神山 俊哉, 藤堂 省
北海道外科雑誌, 56, 1, 67, 68, 北海道外科学会, Jun. 2011
Japanese - 肝胆膵外科領域で習得すべき血行再建手技(1) 肝門部領域胆管系腫瘍に対する血行再建手技の工夫
蒲池 浩文, 神山 俊哉, 田原 宗徳, 柿坂 達彦, 谷口 雅彦, 横尾 英樹, 中西 一彰, 山下 健一郎, 松下 通明, 藤堂 省
日本肝胆膵外科学会・学術集会プログラム・抄録集, 23回, 195, 195, (一社)日本肝胆膵外科学会, Jun. 2011
Japanese - 進行肝癌に対する治療戦略と手術の実際 下大静脈・右心房に進展した原発性肝癌に対する外科治療
中西 一彰, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 田原 宗徳, 蒲池 浩文, 松下 通明, 藤堂 省
日本肝胆膵外科学会・学術集会プログラム・抄録集, 23回, 243, 243, (一社)日本肝胆膵外科学会, Jun. 2011
Japanese - 安全かつ確実な腹腔鏡下肝切除術を目指して(1) 安全かつ確実な腹腔鏡下肝切除術を目指して
神山 俊哉, 中西 一彰, 横尾 英樹, 蒲池 浩文, 田原 宗徳, 柿坂 達彦, 谷口 雅彦, 松下 通明, 藤堂 省
日本肝胆膵外科学会・学術集会プログラム・抄録集, 23回, 256, 256, (一社)日本肝胆膵外科学会, Jun. 2011
Japanese - 肝切除術の新たな工夫(1) 安全な肝切離をめざして ハーモニックスカルペルとVIO systemのsoft凝固モードを用いたDS3.0による肝切離
横尾 英樹, 神山 俊哉, 中西 一彰, 柿坂 達彦, 田原 宗徳, 蒲池 浩文, 松下 通明, 藤堂 省
日本肝胆膵外科学会・学術集会プログラム・抄録集, 23回, 264, 264, (一社)日本肝胆膵外科学会, Jun. 2011
Japanese - ニードルガイディングテクニックを用いた系統的亜区域切除術
柿坂 達彦, 神山 俊哉, 中西 一彰, 横尾 英樹, 蒲池 浩文, 田原 宗徳, 松下 通明, 藤堂 省
日本肝胆膵外科学会・学術集会プログラム・抄録集, 23回, 293, 293, (一社)日本肝胆膵外科学会, Jun. 2011
Japanese - A successful case of systemic chemotherapy followed by liver resection for advanced hepatocellular carcinoma with highly vascular invasion and multiple pulmonary metastases
Tatsuzo Mizukami, Toshiya Kamiyama, Kazuaki Nakanishi, Masahiko Taniguchi, Hideki Yokoo, Munenori Tahara, Tatsuhiko Kakisaka, Hirofumi Kamachi, Michiaki Matsushita, Satoru Todo
Japanese Journal of Cancer and Chemotherapy, 38, 5, 849, 852, Japanese Journal of Cancer and Chemotherapy Publishers Inc., 15 May 2011, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal - 皮膚筋炎を合併した肝細胞癌(HCC)の1例
石黒 友唯, 神山 俊哉, 中西 一彰, 横尾 英樹, 柿坂 達彦, 田原 宗徳, 谷口 雅彦, 蒲池 浩文, 松下 通明, 藤堂 省
北海道外科雑誌, 55, 2, 174, 175, 北海道外科学会, Dec. 2010
Japanese - 広範囲に膵進展を認めた膵頭部癌の1切除例
島田 慎吾, 蒲池 浩文, 田原 宗徳, 柿坂 達彦, 横尾 英樹, 谷口 雅彦, 中西 一彰, 神山 俊哉, 松下 通明, 藤堂 省
北海道外科雑誌, 55, 2, 179, 179, 北海道外科学会, Dec. 2010
Japanese - 術後TS-1投与が奏効した多発肺転移を伴う高度脈管侵襲肝細胞癌の1例
水上 達三, 神山 俊哉, 中西 一彰, 谷口 雅彦, 横尾 英樹, 田原 宗徳, 柿坂 達彦, 蒲池 浩文, 松下 通明, 藤堂 省
日本臨床外科学会雑誌, 71, 10, 2737, 2738, 日本臨床外科学会, Oct. 2010
Japanese - 当科における安全な肝切除の工夫 術前プランニングと術中操作
中西 一彰, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 田原 宗徳, 谷口 雅彦, 蒲池 浩文, 松下 通明, 藤堂 省
日本臨床外科学会雑誌, 71, 増刊, 425, 425, 日本臨床外科学会, Oct. 2010
Japanese - 肝門部領域胆管系腫瘍における血管合併切除 左葉系切除におけるプランニングと手技
蒲池 浩文, 神山 俊哉, 田原 宗徳, 柿坂 達彦, 福森 大介, 谷口 雅彦, 横尾 英樹, 中西 一彰, 山下 健一郎, 松下 通明, 藤堂 省
日本臨床外科学会雑誌, 71, 増刊, 461, 461, 日本臨床外科学会, Oct. 2010
Japanese - 術後胆汁瘻の検討 その原因と対策
横尾 英樹, 神山 俊哉, 中西 一彰, 谷口 雅彦, 田原 宗徳, 柿坂 達彦, 蒲池 浩文, 松下 通明, 藤堂 省
日本臨床外科学会雑誌, 71, 増刊, 533, 533, 日本臨床外科学会, Oct. 2010
Japanese - 1年以内早期に癌死する肝細胞癌切除症例の検討
神山 俊哉, 中西 一彰, 横尾 英樹, 蒲池 浩文, 谷口 雅彦, 田原 宗徳, 柿坂 達彦, 松下 通明, 藤堂 省
日本臨床外科学会雑誌, 71, 増刊, 546, 546, 日本臨床外科学会, Oct. 2010
Japanese - 肝切除の術中操作に伴う胆道狭窄に対する皮下植え込み式胆道内瘻法の有用性
川俣 太, 神山 俊哉, 中西 一彰, 横尾 英樹, 柿坂 達彦, 田原 宗徳, 谷口 雅彦, 蒲池 浩文, 松下 道明, 藤堂 省
日本臨床外科学会雑誌, 71, 増刊, 619, 619, 日本臨床外科学会, Oct. 2010
Japanese - 肝細胞癌術後脳転移症例の検討
柿坂 達彦, 神山 俊哉, 中西 一彰, 横尾 英樹, 蒲池 浩文, 田原 宗徳, 谷口 雅彦, 松下 通明, 藤堂 省
日本臨床外科学会雑誌, 71, 増刊, 729, 729, 日本臨床外科学会, Oct. 2010
Japanese - 皮膚筋炎を合併した肝細胞癌(HCC)の1例
石黒 友唯, 神山 俊哉, 中西 一彰, 横尾 英樹, 柿坂 達彦, 田原 宗徳, 谷口 雅彦, 蒲池 浩文, 松下 通明, 藤堂 省
日本臨床外科学会雑誌, 71, 増刊, 730, 730, 日本臨床外科学会, Oct. 2010
Japanese - 門脈腫瘍栓を伴った退形成性膵癌の一例
田原 宗徳, 蒲池 浩文, 柿坂 達彦, 横尾 英樹, 中西 一彰, 神山 俊哉, 松下 通明, 藤堂 省
日本臨床外科学会雑誌, 71, 増刊, 791, 791, 日本臨床外科学会, Oct. 2010
Japanese - A case of metachronous multiple lung metastases and intraabdominal lymph node metastases of rectal cancer responding to S-1
Tatsuhiko Kakisaka, Fusayoshi Aiki, Tadashi Matsuhisa, Atsuo Hattori, Keizou Kazui
Japanese Journal of Cancer and Chemotherapy, 37, 4, 723, 725, Japanese Journal of Cancer and Chemotherapy Publishers Inc., 06 Apr. 2010, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal - A study of cirrhotic patients with hepatocellular carcinoma and huge splenomegaly who received treatment for hepatocellular carcinoma with concomitant splenectomy
Takeshi Aiyama, Toshiya Kamiyama, Kazuaki Nakanishi, Hideki Yokoo, Masahiko Taniguchi, Daisuke Fukumori, Munenori Tahara, Tatsuya Kakisaka, Hirofumi Kamachi, Michiaki Matsushita, Satoru Todo
Japanese Journal of Cancer and Chemotherapy, 37, 12, 2683, 2686, Japanese Journal of Cancer and Chemotherapy Publishers Inc., 2010, [Peer-reviewed]
Japanese, Scientific journal - Proteomic Profiling Reveals the Prognostic Value of Adenomatous Polyposis Coli-End-Binding Protein 1 in Hepatocellular Carcinoma
Tatsuya Orimo, Hidenori Ojima, Nobuyoshi Hiraoka, Shigeru Saito, Tomoo Kosuge, Tatsuhiko Kakisaka, Hideki Yokoo, Kazuaki Nakanishi, Toshiya Kamiyama, Satoru Todo, Setsuo Hirohashi, Tadashi Kondo
HEPATOLOGY, 48, 6, 1851, 1863, Dec. 2008, [Peer-reviewed], [International Magazine]
English, Scientific journal - Plasma proteomics of pancreatic cancer patients by multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis (2D-DIGE): Up-regulation of leucine-rich alpha-2-glycoprotein in pancreatic cancer
Tatsuhiko Kakisaka, Tadashi Kondo, Tetsuya Okano, Kiyonaga Fujii, Kazufumi Honda, Mitsufumi Endo, Akihiko Tsuchida, Tatsuya Aoki, Takao Itoi, Fuminori Moriyasu, Tesshi Yamada, Harubumi Kato, Toshihide Nishimura, Satoru Todo, Setsuo Hirohashi
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 852, 1-2, 257, 267, Jun. 2007, [Peer-reviewed], [International Magazine]
English, Scientific journal - 【呼吸器と寄生虫】肺の多包性エキノコックス症
佐藤 直樹, 寺崎 康展, 佐々木 彩実, 柿坂 達彦, 横尾 英樹, 山下 健一郎, 中西 一彰, 嶋村 剛, 神山 俊哉, 松下 通明, 藤堂 省
日本胸部臨床, 66, 4, 289, 296, 克誠堂出版(株), Apr. 2007
Japanese - Hepatopulmonary fistula caused by alveolar echinococcosis: Report of a case
Tatsuhiko Kakisaka, Naoki Sato, Toshiya Kamiyama, Takahito Nakagawa, Takahito Nakagawa, Kazuaki Nakanishi, Michiaki Matsushita, Tomoo Ito, Satoru Todo
SURGERY TODAY, 36, 10, 937, 940, Oct. 2006, [Peer-reviewed], [Domestic magazines]
English, Scientific journal - Plasma proteomics of lung cancer by a linkage of multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis
Tetsuya Okano, Tadashi Kondo, Tatsuhiko Kakisaka, Kiyonaga Fujii, Masayo Yamada, Harubumi Kato, Toshihide Nishimura, Akihiko Gemma, Shoji Kudoh, Setsuo Hirohashi
PROTEOMICS, 6, 13, 3938, 3948, Jul. 2006, [Peer-reviewed], [International Magazine]
English, Scientific journal - Plasma proteomics of pancreatic cancer by multi-dimensional liquid chromatography and two-dimensional gel electrophoresis
Kakisaka Tatsuhiko, Kondo Tadashi, Okano Tetsuya, Fujii Kiyonaga, Nishimura Toshihide, Todo Satoru, Hirohashi Setsuo
Abstracts for Annual Meeting of Japanese Proteomics Society, 2005, 137, 137, Japanese Proteomics Society (Japan Human Proteome Organisation), 2005
The mortality rate of pancreatic adenocarcinoma is the highest among all cancer types, because of a lack of specific symptoms in the early stages, limitations of diagnostic methods, and the lack of response to all present treatments. We conducted plasma proteomics to identify the plasma proteins, the expression of which is aberrantly regulated in pancreatic cancer, in order to develop the specific and sensitive tumor markers for early diagnosis. To reduce the complexity and dynamic range of plasma proteome, we combined multi-dimensional liquid chromatography with 2D-PAGE. In our system, highly abundant proteins were depleted by Multiple Affinity Removal Column (Agilent) and the flow through fraction was separated by anion exchange column. For accurate quantitative comparison of protein expression profiles, the fractioned proteins were labeled with fluorescent dyes, which were developed for two-dimensional difference gel electrophoresis (2D-DIGE). The number of protein spots was increased from 290 to 403 spots by depleting the abundant proteins, then further increased up to 1098 by fractionation with anion exchange chromatography, provably due to the reduced complexity and dynamic range of plasma proteome. We selected 39 protein spots, whose intensity was significantly different in amount by more than 2-fold between the patients with pancreatic cancer and the healthy volunteers. The proteins corresponding to the selected protein spots were determined by mass spectrometry, and the identification of the proteins was confirmed by specific antibodies. A combination of multi-dimensional liquid chromatography with 2D-PAGE is a powerful tool for plasma proteomics. The identified proteins will be a candidate for diagnostic tumor marker and provide a clue to understand the molecular background of pancreatic cancer. - 旭川厚生病院外科手術集計-2002年報
赤羽 弘充, 高橋 昌宏, 中野 詩朗, 稲垣 光裕, 河田 聡, 安原 満夫, 青木 貴徳, 野村 克, 横尾 英樹, 唐崎 秀則, 柿坂 達彦, 青柳 武史, 小片 武, 山田 理大, 宇野 元博, 尾崎 篤子, 斉藤 芳儀, 菊地 信明, 菅原 かおり, 柳田 翼, 橋本 晃佳
旭川厚生病院医誌, 13, 1, 62, 66, 旭川厚生病院, Jun. 2003
Japanese - 異時性肝転移をきたした直腸カルチノイドの1例
柿坂 達彦, 中野 詩朗, 尾崎 篤子, 宇野 元博, 唐崎 秀則, 野村 克, 青木 貴徳, 安原 満夫, 赤羽 弘充, 船井 哲雄, 高橋 昌宏
旭川厚生病院医誌, 12, 2, 106, 109, 旭川厚生病院, Dec. 2002
Japanese
Other Activities and Achievements
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深澤拓夢, 旭火華, 柿坂達彦, 長津明久, 相山健, 藤居勇貴, 志智俊介, 山本葉一, 後藤了一, 渡辺正明, 川村典生, 武冨紹信, 制癌剤適応研究会プログラム・抄録集, 57th, 2025 - 分子標的薬がBCLC stage Cの肝細胞癌の手術成績に与えた影響
旭火華, 柿坂達彦, 折茂達也, 長津明久, 相山健, 脇坂和貴, 志智俊介, 武冨紹信, 日本癌治療学会学術集会(Web), 62nd, 2024 - Prediction for Gastrointestinal Toxicity in Patients with Pancreatic Cancer Treated with Concurrent Chemoradiotherapy
KOIZUMI Fuki, KATOH Norio, KANEHIRA Takahiro, KAWAMOTO Yasuyuki, NAKAMURA Toru, KAKISAKA Tatsuhiko, UCHINAMI Yusuke, YOKOTA Isao, KOBASHI Keiji, AOYAMA Hidefumi, 日本医学放射線学会総会抄録集, 83rd, 2024 - Curative Liver Resection in a Case of Cecum Cancer Liver Metastasis after Coronavirus Disease-19 Following Percutaneous Transhepatic Portal Vein Embolization
藤好直, 柿坂達彦, 松澤文彦, 下國達志, 木井修平, 蔵谷勇樹, 西川眞, 森田亮, 中西勝也, 高木智史, 高橋昌宏, 日本消化器外科学会雑誌(Web), 55, 6, 2022 - 肝細胞癌における術後末梢血白血球分画の術後早期再発の関連性
旭 よう, 神山 俊哉, 柿坂 達彦, 折茂 達也, 長津 明久, 坂本 譲, 武冨 紹信, 肝臓, 62, Suppl.1, A373, A373, Apr. 2021
(一社)日本肝臓学会, Japanese - 進行肝細胞癌に対する集学的治療の意義-薬物療法は手術を変えたか- 根治切除不能肝細胞癌に対する減量肝切除/分子標的薬sequential治療の意義についての検討
旭 よう, 神山 俊哉, 柿坂 達彦, 折茂 達也, 島田 慎吾, 長津 明久, 坂本 譲, 蒲池 浩文, 武冨 紹信, 日本外科学会定期学術集会抄録集, 121回, WS, 8, Apr. 2021
(一社)日本外科学会, Japanese - 肝細胞癌における間質Versicanの発現と予後に関する検討
加藤 紘一, 深井 原, 坂本 譲, 旭 よう, 長津 明久, 折茂 達也, 柿坂 達彦, 蒲池 浩文, 神山 俊哉, 武冨 紹信, 日本外科学会定期学術集会抄録集, 121回, SF, 8, Apr. 2021
(一社)日本外科学会, Japanese - 肝細胞癌に対する肝切除後予後因子としてのGd-EOB-DTPA-MRIの意義
島田 慎吾, 神山 俊哉, 柿坂 達彦, 折茂 達也, 長津 明久, 旭 よう, 坂本 譲, 蒲池 浩文, 武冨 紹信, 日本外科学会定期学術集会抄録集, 121回, SF, 2, Apr. 2021
(一社)日本外科学会, Japanese - Propensity scoreを用いた解析によるvp3、4肝細胞癌の門脈腫瘍栓に対する術前放射線治療の有効性の検討
柿坂 達彦, 神山 俊哉, 折茂 達也, 長津 明久, 旭 よう, 坂本 譲, 蒲池 浩文, 加藤 徳雄, 畑中 佳奈子, 武冨 紹信, 日本外科学会定期学術集会抄録集, 121回, SF, 3, Apr. 2021
(一社)日本外科学会, Japanese - EOB-MRIを用いた術後肝不全予測の有用性
折茂 達也, 神山 俊哉, 柿坂 達彦, 長津 明久, 旭 よう, 坂本 譲, 蒲池 浩文, 武冨 紹信, 日本外科学会定期学術集会抄録集, 121回, SF, 3, Apr. 2021
(一社)日本外科学会, Japanese - 局所進行膵癌に対するメトホルミン併用術前化学放射線療法の効果
蒲池 浩文, 折茂 達也, 柿坂 達彦, 敦賀 陽介, 若山 顕示, 島田 慎吾, 長津 明久, 旭 よう, 坂本 譲, 神山 俊哉, 武冨 紹信, 日本外科学会定期学術集会抄録集, 121回, SF, 7, Apr. 2021
(一社)日本外科学会, Japanese - 腹腔鏡下肝切除における実質切離方法と成績の検討
長津 明久, 神山 俊哉, 坂本 譲, 旭 よう, 折茂 達也, 柿坂 達彦, 蒲池 浩文, 武冨 紹信, 日本外科学会定期学術集会抄録集, 121回, PS, 5, Apr. 2021
(一社)日本外科学会, Japanese - 肝エキノコックス症に対する下大静脈切除再建を伴う肝切除治療成績
神山 俊哉, 柿坂 達彦, 折茂 達也, 長津 明久, 旭 よう, 坂本 譲, 蒲池 浩文, 嶋村 剛, 武冨 紹信, 日本外科学会定期学術集会抄録集, 121回, PS, 1, Apr. 2021
(一社)日本外科学会, Japanese - 肥満合併肝細胞癌患者における肝切除の検討
坂本 譲, 神山 俊哉, 島田 慎吾, 折茂 達也, 長津 明久, 旭 よう, 柿坂 達彦, 蒲池 浩文, 武冨 紹信, 日本外科学会定期学術集会抄録集, 121回, PS, 8, Apr. 2021
(一社)日本外科学会, Japanese - 肝細胞癌切除例におけるCOPZ1発現と予後の検討
加藤 拓也, 折茂 達也, 柿坂 達彦, 蒲池 浩文, 神山 俊哉, 武冨 紹信, 日本外科学会定期学術集会抄録集, 121回, PS, 1, Apr. 2021
(一社)日本外科学会, Japanese - 肝前区域切除術後に胆管狭窄に伴う肝後区域の萎縮を呈した2例
石川 倫啓, 柿坂 達彦, 坂本 譲, 旭 よう, 長津 明久, 島田 慎吾, 折茂 達也, 蒲池 浩文, 神山 俊哉, 武冨 紹信, 日本外科学会定期学術集会抄録集, 121回, PS, 8, Apr. 2021
(一社)日本外科学会, Japanese - 心嚢穿破を伴う肝エキノコックス症に対して外科的治療が奏功した1例
山本 葉一, 神山 俊哉, 柿坂 達彦, 折茂 達也, 旭 よう, 長津 明久, 坂本 譲, 蒲池 浩文, 武冨 紹信, 日本外科学会定期学術集会抄録集, 121回, RS, 3, Apr. 2021
(一社)日本外科学会, Japanese - 十二指腸原発悪性Triton腫瘍術後13年目に発生した肝転移の一例
大橋 慶太, 神山 俊哉, 柿坂 達彦, 折茂 達也, 長津 明久, 旭 よう, 坂本 譲, 蒲池 浩文, 大塚 拓也, 三橋 智子, 杉田 真太朗, 武冨 紹信, 日本外科学会定期学術集会抄録集, 121回, RS, 9, Apr. 2021
(一社)日本外科学会, Japanese - 増大傾向を示す肝外門脈瘤に対し門脈形成術を施行した一例
石川 昂弥, 長津 明久, 坂本 譲, 旭 よう, 折茂 達也, 柿坂 達彦, 蒲池 浩文, 神山 俊哉, 武冨 紹信, 日本外科学会定期学術集会抄録集, 121回, RS, 10, Apr. 2021
(一社)日本外科学会, Japanese - 悪性黒色腫の肝転移に対して肝切除を行った4症例の報告
旭 よう, 神山 俊哉, 柿坂 達彦, 折茂 達也, 長津 明久, 坂本 譲, 蒲池 浩文, 竹内 啓, 三橋 智子, 武冨 紹信, 日本消化器病学会雑誌, 118, 臨増総会, A390, A390, Mar. 2021
(一財)日本消化器病学会, Japanese - 後期高齢者における経皮経肝的門脈塞栓術を要する大量肝切除の検討
坂本 譲, 神山 俊哉, 島田 慎吾, 折茂 達也, 長津 明久, 旭 よう, 柿坂 達彦, 蒲池 浩文, 武冨 紹信, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 128回・122回, 57, 57, Mar. 2021
日本消化器病学会-北海道支部, Japanese - 肝臓 周術期管理
坂本 譲, 神山 俊哉, 島田 慎吾, 折茂 達也, 長津 明久, 旭 よう, 柿坂 達彦, 蒲池 浩文, 武冨 紹信, 日本消化器外科学会雑誌, 53, Suppl.2, 238, 238, Nov. 2020
(一社)日本消化器外科学会, Japanese - 腹腔鏡下同時肝・消化管切除15症例の検討
旭 よう, 神山 俊哉, 柿坂 達彦, 折茂 達也, 島田 慎吾, 長津 明久, 坂本 譲, 蒲池 浩文, 武冨 紹信, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 127回・121回, 41, 41, Oct. 2020
日本消化器病学会-北海道支部, Japanese - 肝切除を施行後集学的治療にて長期生存が得られているG-CSF産生肝細胞癌の1例
坂本 譲, 神山 俊哉, 旭 よう, 長津 明久, 島田 慎吾, 折茂 達也, 柿坂 達彦, 蒲池 浩文, 武冨 紹信, 日本癌治療学会学術集会抄録集, 58回, P, 190, Oct. 2020
(一社)日本癌治療学会, Japanese - Xenograftマウスモデルを用いた抗メソテリン抗体の早期投与による膵癌肝転移抑制効果の検討
藤居 勇貴, 蒲池 浩文, 深井 原, 折茂 達也, 坂本 譲, 旭 よう, 長津 明久, 島田 慎吾, 柿坂 達彦, 神山 俊哉, 武冨 紹信, 日本癌学会総会記事, 79回, OJ14, 4, Oct. 2020
(一社)日本癌学会, English - 右側・左側を考慮したStageIV大腸癌の治療戦略
野口 慶太, 志智 俊介, 金沢 亮, 乾野 幸子, 柿坂 達彦, 田原 宗徳, 高橋 周作, 山上 英樹, 石津 寛之, 日本大腸肛門病学会雑誌, 72, 5, 304, 304, May 2019
(一社)日本大腸肛門病学会, Japanese - XELOX+bevacizumab療法が奏効しR0切除が得られたAFP産生大腸癌同時性肝転移の1例
沢田 尭史, 本間 重紀, 吉田 雅, 柴崎 晋, 川村 秀樹, 若山 顕治, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 小松 嘉人, 結城 敏志, 畑中 佳奈子, 武冨 紹信, 日本外科系連合学会誌, 43, 5, 845, 854, Oct. 2018
日本外科系連合学会, Japanese - XELOX+bevacizumab療法が奏効しR0切除が得られたAFP産生大腸癌同時性肝転移の1例
沢田 尭史, 本間 重紀, 吉田 雅, 柴崎 晋, 川村 秀樹, 若山 顕治, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 小松 嘉人, 結城 敏志, 畑中 佳奈子, 武冨 紹信, 日本外科系連合学会誌, 43, 5, 845, 854, Oct. 2018
日本外科系連合学会, Japanese - 7年目外科医師の現状と挑戦
金沢 亮, 志智 俊介, 乾野 幸子, 野口 慶太, 柿坂 達彦, 田原 宗徳, 山上 英樹, 高橋 周作, 秦 庸壮, 田中 浩一, 石津 寛之, 高橋 弘昌, 日本臨床外科学会雑誌, 79, 6, 1324, 1324, Jun. 2018
日本臨床外科学会, Japanese - 経カテーテル的動脈塞栓術が奏功した特発性大網出血の2例
丸山 英理, 金沢 亮, 志智 俊介, 乾野 幸子, 野口 慶太, 柿坂 達彦, 田原 宗徳, 山上 英樹, 高橋 周作, 秦 庸壮, 田中 浩一, 石津 寛之, 日本臨床外科学会雑誌, 79, 6, 1338, 1338, Jun. 2018
日本臨床外科学会, Japanese - Clear cell sarcoma-like tumor of the gastrointestinal tractの1例
志智 俊介, 高橋 周作, 金沢 亮, 乾野 幸子, 野口 慶太, 柿坂 達彦, 田原 宗徳, 山上 英樹, 秦 庸壮, 田中 浩一, 高橋 弘昌, 市原 真, 石津 寛之, 日本臨床外科学会雑誌, 79, 3, 614, 614, Mar. 2018
日本臨床外科学会, Japanese - 炎症性腸疾患の腹腔鏡下大腸切除術における右側結腸の後腹膜アプローチの有用性
山上 英樹, 志智 俊介, 金沢 亮, 乾野 幸子, 野口 慶太, 柿坂 達彦, 田原 宗徳, 高橋 周作, 日本内視鏡外科学会雑誌, 22, 7, EP054, 07, Dec. 2017
(一社)日本内視鏡外科学会, Japanese - 肥満患者への大腸癌腹腔鏡下手術の適応
野口 慶太, 志智 俊介, 金沢 亮, 乾野 幸子, 柿坂 達彦, 田原 宗徳, 山上 英樹, 高橋 周作, 日本内視鏡外科学会雑誌, 22, 7, EP176, 05, Dec. 2017
(一社)日本内視鏡外科学会, Japanese - 小腸アニサキス症の1例
金沢 亮, 柿坂 達彦, 志智 俊介, 乾野 幸子, 野口 慶太, 田原 宗徳, 山上 英樹, 高橋 周作, 秦 庸荘, 田中 浩一, 石津 寛之, 高橋 弘昌, 北海道外科雑誌, 62, 2, 175, 176, Dec. 2017
北海道外科学会, Japanese - 壁外性発育を示した直腸原発平滑筋腫の1例
箕浦 愛, 山上 英樹, 松本 哲, 乾野 幸子, 及川 芳徳, 野口 慶太, 柿坂 達彦, 田原 宗徳, 高橋 周作, 秦 庸壮, 田中 浩一, 石津 寛之, 高橋 弘昌, 高橋 昌宏, 日本臨床外科学会雑誌, 78, 9, 2167, 2167, Sep. 2017
日本臨床外科学会, Japanese - S状結腸切除術後に発症した下腸間膜動静脈瘻によるうっ血性大腸炎の1例
山上 英樹, 松本 哲, 乾野 幸子, 及川 芳徳, 野口 慶太, 柿坂 達彦, 田原 宗徳, 高橋 周作, 秦 庸壮, 田中 浩一, 石津 寛之, 高橋 弘昌, 高橋 昌宏, 日本臨床外科学会雑誌, 78, 9, 2167, 2168, Sep. 2017
日本臨床外科学会, Japanese - 腹腔鏡下低位前方切除術の恥骨上ポートを用いた術野展開の工夫
野口 慶太, 松本 哲, 乾野 幸子, 柿坂 達彦, 田原 宗徳, 高橋 周作, 山上 英樹, 石津 寛之, 高橋 昌宏, 日本大腸肛門病学会雑誌, 70, 8, 568, 568, Aug. 2017
(一社)日本大腸肛門病学会, Japanese - 大腸癌に対する開腹手術と腹腔鏡手術の成績
野口 慶太, 松本 哲, 乾野 幸子, 及川 芳徳, 柿坂 達彦, 田原 宗徳, 高橋 周作, 山上 英樹, 石津 寛之, 高橋 昌宏, 日本大腸肛門病学会雑誌, 70, 5, 377, 377, May 2017
(一社)日本大腸肛門病学会, Japanese - StageIV大腸癌におけるM1aとM1b症例の予後の比較
野口 慶太, 石川 倫啓, 蓮実 健太, 松本 哲, 久慈 麻里子, 柿坂 達彦, 田原 宗徳, 高橋 周作, 山上 英樹, 秦 庸壮, 田中 浩一, 石津 寛之, 高橋 弘昌, 高橋 昌宏, 日本大腸肛門病学会雑誌, 70, 4, 274, 274, Apr. 2017
(一社)日本大腸肛門病学会, Japanese - 遠隔転移を有する大腸癌に対する治療戦略
野口 慶太, 松本 哲, 乾野 幸子, 柿坂 達彦, 田原 宗徳, 高橋 周作, 山上 英樹, 石津 寛之, 高橋 昌宏, 日本外科学会定期学術集会抄録集, 117回, PS, 7, Apr. 2017
(一社)日本外科学会, Japanese - 拡大手術を要し、術後に病理学的診断を得た虫垂腫瘤性病変の2例
山上 英樹, 松本 哲, 乾野 幸子, 及川 芳徳, 野口 慶太, 柿坂 達彦, 田原 宗徳, 高橋 周作, 秦 庸壮, 田中 浩一, 石津 寛之, 高橋 弘昌, 高橋 昌宏, 日本大腸肛門病学会雑誌, 70, 2, 90, 91, Feb. 2017
(一社)日本大腸肛門病学会, Japanese - 根治的肝切除治療を施行した同時性肝転移を有する大腸癌の検討
山上 英樹, 石津 寛之, 高橋 昌宏, 高橋 周作, 田原 宗徳, 柿坂 達彦, 久慈 麻里子, 野口 慶太, 松本 哲, 日本大腸肛門病学会雑誌, 70, 2, 125, 125, Feb. 2017
(一社)日本大腸肛門病学会, Japanese - 同時性肝転移を伴った大腸癌に対する腹腔鏡下大腸・肝同時切除の安全性
吉田 雅, 本間 重紀, 柴崎 晋, 下國 達志, 崎浜 秀康, 高橋 典彦, 川村 秀樹, 柿坂 達彦, 神山 俊哉, 武冨 紹信, 日本大腸肛門病学会雑誌, 70, 2, 138, 138, Feb. 2017
(一社)日本大腸肛門病学会, Japanese - 網羅的糖鎖解析による肝細胞癌の浸潤能と糖鎖異常の検討
高橋秀徳, 神山俊哉, 柿坂達彦, 相山健, 島田慎吾, 若山顕治, 永生高弘, 折茂達也, 蒲池浩文, 横尾英樹, 西村紳一郎, 武冨紹信, 日本外科学会定期学術集会(Web), 117th, ROMBUNNO.PS‐076‐4 (WEB ONLY), 685, 2017
(一社)日本消化器外科学会, Japanese - ESD後追加切除症例に対する腹腔鏡下幽門側胃切除術の検討
松本 哲, 高橋 周作, 高橋 昌宏, 及川 芳徳, 野口 慶太, 久慈 麻里子, 柿坂 達彦, 田原 宗徳, 山上 英樹, 石津 寛之, 北海道外科雑誌, 61, 2, 162, 165, Dec. 2016
北海道外科学会, Japanese - 炎症性腸疾患に対する腹腔鏡下大腸全摘術の検討
山上 英樹, 松本 哲, 乾野 幸子, 及川 芳徳, 野口 慶太, 柿坂 達彦, 田原 宗徳, 高橋 周作, 日本内視鏡外科学会雑誌, 21, 7, OS160, 5, Dec. 2016
(一社)日本内視鏡外科学会, Japanese - 大腸癌に対する腹腔鏡手術の成績
野口 慶太, 松本 哲, 乾野 幸子, 及川 芳徳, 柿坂 達彦, 田原 宗徳, 高橋 周作, 山上 英樹, 日本内視鏡外科学会雑誌, 21, 7, OS162, 7, Dec. 2016
(一社)日本内視鏡外科学会, Japanese - 肝pseudolymphomaの3切除例
金野 匠, 柿坂 達彦, 田原 宗徳, 石津 寛之, 高橋 昌宏, 岩口 佳史, 市原 真, 後藤田 裕子, 村岡 俊二, 日本臨床外科学会雑誌, 77, 11, 2810, 2810, Nov. 2016
日本臨床外科学会, Japanese - 治癒切除不能進行・再発胃癌に対するオキサリプラチン併用療法の使用経験
及川 芳徳, 高橋 昌宏, 高橋 周作, 松本 哲, 乾野 幸子, 野口 慶太, 柿坂 達彦, 田原 宗徳, 山上 英樹, 石津 寛之, 癌と化学療法, 43, 12, 1579, 1581, Nov. 2016
(株)癌と化学療法社, Japanese - 肝癌細胞株における糖鎖異常とu-PA発現変化に伴う浸潤能の解析
高橋 秀徳, 神山 俊哉, 相山 健, 折茂 達也, 柿坂 達彦, 横尾 英樹, 武冨 紹信, 日本癌学会総会記事, 75回, P, 1293, Oct. 2016
日本癌学会, English - splenorenal shuntによる高アンモニア血症を呈した虫垂癌腹膜播種再発の1例
松本 哲, 乾野 幸子, 及川 芳徳, 野口 慶太, 柿坂 達彦, 田原 宗徳, 高橋 周作, 山上 英樹, 石津 寛之, 高橋 昌宏, 日本農村医学会雑誌, 65, 3, 532, 532, Sep. 2016
(一社)日本農村医学会, Japanese - 多包性エキノコックス症5切除例についての検討
及川 芳徳, 柿坂 達彦, 松本 哲, 乾野 幸子, 野口 慶太, 田原 宗徳, 高橋 周作, 山上 英樹, 石津 寛之, 高橋 昌宏, 日本農村医学会雑誌, 65, 3, 671, 671, Sep. 2016
(一社)日本農村医学会, Japanese - 切除不能胃癌に対するramucirumabの投与経験
松本 哲, 高橋 周作, 蓮実 健太, 野口 慶太, 久慈 麻里子, 柿坂 達彦, 田原 宗徳, 山上 英樹, 秦 庸壮, 田中 浩一, 石津 寛之, 高橋 弘昌, 高橋 昌宏, 阿部 雅一, 日本臨床外科学会雑誌, 77, 9, 2335, 2335, Sep. 2016
日本臨床外科学会, Japanese - 内視鏡外科認定医取得のコツ 大腸手術
野口 慶太, 松本 哲, 及川 芳徳, 久慈 麻里子, 柿坂 達彦, 田原 宗徳, 高橋 周作, 山上 英樹, 石津 寛之, 高橋 昌宏, 日本消化器外科学会総会, 71回, P1, 5, Jul. 2016
(一社)日本消化器外科学会, Japanese - 当科における胃癌術後補助化学療法の現状と継続性に関する検討
高橋 周作, 松本 哲, 久慈 麻里子, 及川 芳徳, 野口 慶太, 柿坂 達彦, 田原 宗徳, 山上 英樹, 石津 寛之, 高橋 昌宏, 日本消化器外科学会総会, 71回, P2, 4, Jul. 2016
(一社)日本消化器外科学会, Japanese - 他臓器浸潤大腸癌切除症例についての検討
及川 芳徳, 野口 慶太, 山上 英樹, 松本 哲, 久慈 麻里子, 柿坂 達彦, 田原 宗徳, 高橋 周作, 石津 寛之, 高橋 昌宏, 日本消化器外科学会総会, 71回, P3, 5, Jul. 2016
(一社)日本消化器外科学会, Japanese - 大腸癌同時性肝転移に対する外科治療と化学療法の役割
山上 英樹, 高橋 昌宏, 石津 寛之, 高橋 周作, 田原 宗徳, 柿坂 達彦, 久慈 麻里子, 野口 慶太, 及川 芳徳, 松本 哲, 日本消化器外科学会総会, 71回, P3, 7, Jul. 2016
(一社)日本消化器外科学会, Japanese - 安全で低侵襲な肝葉切除のコツ 安全な開腹式肝葉切除に関する術法(Tips and tricks of safe and less-invasive hepatic lobectomy Our surgical techniques for safe open hepatic lobectomy)
柿坂 達彦, 神山 俊哉, 横尾 英樹, 折茂 達也, 若山 顕治, 島田 慎吾, 敦賀 陽介, 蒲池 浩文, 石津 寛之, 武冨 紹信, 日本消化器外科学会総会, 71回, SY14, 1, Jul. 2016
(一社)日本消化器外科学会, English - 肝前区域切除術後に胆道狭窄を発症した2例
太田拓児, 神山俊哉, 横尾英樹, 柿坂達彦, 折茂達也, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, IVR, 31, 2, 174, 174, 20 Jun. 2016
(一社)日本インターベンショナルラジオロジー学会, Japanese - 門脈ガス血症及び腸管気腫を伴う慢性偽性腸閉塞の1例
松本 哲, 高橋 周作, 蓮実 健太, 久慈 麻里子, 及川 芳徳, 野口 慶太, 柿坂 達彦, 田原 宗徳, 山上 英樹, 秦 庸壮, 田中 浩一, 石津 寛之, 高橋 弘昌, 高橋 昌宏, 北海道外科雑誌, 61, 1, 101, 101, Jun. 2016
北海道外科学会, Japanese - Operative planning and pitfalls during highly advanced HBP Surgery; Liver 肝不全発生防止を目指した大量肝切除における術前計画の進歩(Operative planning and pitfalls during highly advanced HBP Surgery: Liver Operative planning for major hepatectomy to prevent liver failure)
武冨 紹信, 敦賀 陽介, 島田 慎吾, 若山 顕治, 折茂 達也, 柿坂 達彦, 横尾 英樹, 蒲池 浩文, 神山 俊哉, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 28回, 326, 326, Jun. 2016
(一社)日本肝胆膵外科学会, English - FPD搭載IVRシステム導入後のHCCに対する超選択的Lip-TACEの治療成績
阿保 大介, 作原 祐介, 曽山 武士, 高橋 文也, 木村 輔, 工藤 與亮, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 荘 拓也, 小川 浩司, IVR: Interventional Radiology, 31, 2, 175, 175, Jun. 2016
(一社)日本インターベンショナルラジオロジー学会, Japanese - StageIV大腸癌の治療成績
野口 慶太, 石川 倫啓, 蓮実 建太, 松本 哲, 久慈 麻里子, 柿坂 達彦, 田原 宗徳, 高橋 周作, 山上 英樹, 秦 庸壮, 田中 浩一, 石津 寛之, 高橋 弘昌, 高橋 昌宏, 日本外科学会定期学術集会抄録集, 116回, PS, 3, Apr. 2016
(一社)日本外科学会, Japanese - 胃癌手術症例における好中球・リンパ球比の臨床的意義
松本 哲, 高橋 周作, 石川 倫啓, 蓮実 健太, 野口 慶太, 久慈 麻里子, 柿坂 達彦, 田原 宗徳, 山上 英樹, 秦 庸壮, 田中 浩一, 石津 寛之, 高橋 弘昌, 高橋 昌宏, 日本外科学会定期学術集会抄録集, 116回, PS, 1, Apr. 2016
(一社)日本外科学会, Japanese - 食道胃接合部癌の治療戦略 食道胃接合部腺癌切除例における至適治療法の検討
高橋 周作, 松本 哲, 石川 倫啓, 蓮実 建太, 野口 慶太, 久慈 麻里子, 柿坂 達彦, 田原 宗徳, 山上 英樹, 石津 寛之, 高橋 昌宏, 日本外科学会定期学術集会抄録集, 116回, WS, 3, Apr. 2016
(一社)日本外科学会, Japanese - 診断が困難だった卵黄腸管遺残捻転の一例
石川 倫啓, 高橋 周作, 松本 悠, 蓮実 健太, 松本 哲, 野口 慶太, 柿坂 達彦, 久慈 麻里子, 田原 宗徳, 山上 英樹, 秦 庸壮, 田中 浩一, 石津 寛之, 高橋 弘昌, 高橋 昌宏, 日本臨床外科学会雑誌, 77, 3, 704, 704, Mar. 2016
日本臨床外科学会, Japanese - 血尿を主訴に診断された虫垂粘液癌の1例
松本 悠, 野口 慶太, 石川 倫啓, 蓮実 建太, 松本 哲, 久慈 麻里子, 柿坂 達彦, 田原 宗徳, 高橋 周作, 山上 英樹, 秦 庸壮, 田中 浩一, 石津 寛之, 高橋 弘昌, 高橋 昌宏, 日本臨床外科学会雑誌, 77, 3, 705, 705, Mar. 2016
日本臨床外科学会, Japanese - 食道胃接合部腺癌における術式に関する検討
高橋 周作, 松本 哲, 石川 倫啓, 野口 慶太, 久慈 麻里子, 柿坂 達彦, 田原 宗徳, 山上 英樹, 石津 寛之, 高橋 昌宏, 日本胃癌学会総会記事, 88回, 191, 191, Mar. 2016
(一社)日本胃癌学会, Japanese - 胃癌手術症例における術前好中球・リンパ球比の臨床的意義
松本 哲, 高橋 周作, 野口 慶太, 久慈 麻里子, 柿坂 達彦, 田原 宗徳, 山上 英樹, 秦 庸壮, 田中 浩一, 石津 寛之, 高橋 弘昌, 高橋 昌宏, 日本胃癌学会総会記事, 88回, 369, 369, Mar. 2016
(一社)日本胃癌学会, Japanese - Transparenchymal Glissonean Approach (TGA): New Surgical Technique of Left Side Hepatectomy for Advanced Perihilar Cholangiocarcinoma
蒲池浩文, 敦賀陽介, 島田慎吾, 若山顕治, 折茂達也, 横尾英樹, 柿坂達彦, 田原宗徳, 後藤了一, 山下健一郎, 神山俊哉, 武冨紹信, 癌の臨床, 61, 6, 403‐408, 408, 05 Feb. 2016
(株)篠原出版新社, Japanese - 網羅的糖鎖解析による肝細胞癌の浸潤能と糖鎖異常の検討
高橋秀徳, 神山俊哉, 柿坂達彦, 相山健, 島田慎吾, 永生高広, 若山顕治, 折茂達也, 蒲池浩文, 横尾英樹, 西村紳一郎, 武冨紹信, 日本消化器癌発生学会総会プログラム・抄録集, 27th, 104, 2016
Japanese - 傾向スコアマッチング法を用いたvp3,4肝細胞癌の門脈腫瘍栓に対する術前放射線治療の有効性の検討
柿坂達彦, 神山俊哉, 横尾英樹, 折茂達也, 若山顕治, 島田慎吾, 敦賀陽介, 蒲池浩文, 田原宗徳, 石津寛之, 武冨紹信, 日本外科学会定期学術集会(Web), 116th, PD‐11‐6 (WEB ONLY), 6, 2016
(一社)日本外科学会, Japanese - 肝癌細胞株におけるuPAの発現変化に伴う浸潤能変化と糖鎖異常解析
高橋秀徳, 柿坂達彦, 神山俊哉, 相山健, 島田慎吾, 若山顕治, 折茂達也, 敦賀陽介, 蒲池浩文, 横尾英樹, 西村紳一郎, 武冨紹信, 日本外科学会定期学術集会(Web), 116th, OP‐090‐1 (WEB ONLY), 1, 2016
(一社)日本外科学会, Japanese - 技術認定医を取得する立場から指導する立場へ
野口 慶太, 松本 哲, 柿坂 達彦, 久慈 麻里子, 田原 宗徳, 山上 英樹, 西澤 祐吏, 伊藤 雅昭, 高橋 周作, 日本内視鏡外科学会雑誌, 20, 7, OS73, 2, Dec. 2015
(一社)日本内視鏡外科学会, Japanese - 横行結腸癌に対する内側アプローチを主体とした腹腔鏡下結腸切除術
山上 英樹, 野口 慶太, 高橋 周作, 田原 宗徳, 柿坂 達彦, 久慈 麻里子, 松本 哲, 日本内視鏡外科学会雑誌, 20, 7, OS74, 2, Dec. 2015
(一社)日本内視鏡外科学会, Japanese - 当科の三角吻合による腹腔鏡下BillrothI法再建の工夫
高橋 周作, 松本 哲, 石川 倫啓, 蓮実 建太, 野口 慶太, 久慈 麻里子, 柿坂 達彦, 田原 宗徳, 山上 英樹, 石津 寛之, 高橋 昌宏, 日本内視鏡外科学会雑誌, 20, 7, OS97, 3, Dec. 2015
(一社)日本内視鏡外科学会, Japanese - 腹腔鏡下幽門側胃切除術における電動Stapling System(iDrive)の有用性
松本 哲, 高橋 周作, 野口 慶太, 久慈 麻里子, 柿坂 達彦, 田原 宗徳, 山上 英樹, 日本内視鏡外科学会雑誌, 20, 7, OS104, 5, Dec. 2015
(一社)日本内視鏡外科学会, Japanese - 粘膜下異所性胃腺から発生した胃癌の1切除例
石川 倫啓, 高橋 周作, 蓮実 健太, 松本 哲, 野口 慶太, 柿坂 達彦, 久慈 麻里子, 田原 宗徳, 山上 英樹, 秦 庸壮, 田中 浩一, 石津 寛之, 高橋 弘昌, 高橋 昌宏, 北海道外科雑誌, 60, 2, 196, 197, Dec. 2015
北海道外科学会, Japanese - 肝細胞癌遠隔転移に対するソラフェニブ治療の有効性
横尾 英樹, 神山 俊哉, 柿坂 達彦, 折茂 達也, 若山 顕治, 島田 慎吾, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 癌と化学療法, 42, 12, 1497, 1499, Nov. 2015
(株)癌と化学療法社, Japanese - 肝切除術における術前腸管処置のSSI発生に及ぼす影響についての検討
折茂達也, 神山俊哉, 横尾英樹, 柿坂達彦, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本臨床外科学会雑誌, 76, 10, 2587, 2587, 25 Oct. 2015
日本臨床外科学会, Japanese - 上腹部を占拠する巨大肝血管腫の一切除例
千田圭悟, 神山俊哉, 横尾英樹, 柿坂達彦, 折茂達也, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本臨床外科学会雑誌, 76, 10, 2594, 2594, 25 Oct. 2015
日本臨床外科学会, Japanese - 胆嚢摘出から26年後に発症した遺残胆嚢管癌の1例
坂本聡大, 蒲池浩文, 敦賀陽介, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 日本臨床外科学会雑誌, 76, 10, 2593, 2593, 25 Oct. 2015
日本臨床外科学会, Japanese - 同時性肝転移を伴った大腸癌に対する腹腔鏡下大腸・肝同時切除の安全性
吉田雅, 本間重紀, 下國達志, 崎浜秀康, 高橋典彦, 高橋典彦, 川村秀樹, 柿坂達彦, 神山俊哉, 武冨紹信, 日本臨床外科学会雑誌, 76, 651, 20 Oct. 2015
Japanese - 当院の胃癌手術症例におけるmGPS(modified Glasgow Prognostic Score)を用いた術後合併症と長期予後の検討
石川 倫啓, 高橋 周作, 蓮実 健太, 松本 哲, 野口 慶太, 柿坂 達彦, 久慈 麻里子, 田原 宗徳, 山上 英樹, 秦 庸壮, 田中 浩一, 石津 寛之, 高橋 弘昌, 高橋 昌宏, 日本臨床外科学会雑誌, 76, 増刊, 690, 690, Oct. 2015
日本臨床外科学会, Japanese - 下大静脈閉塞を伴った多包性エキノコックス症の1例
千田圭悟, 神山俊哉, 横尾英樹, 柿坂達彦, 折茂達也, 若山顕治, 加藤拓也, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本臨床外科学会雑誌, 76, 9, 2345, 2346, 25 Sep. 2015
日本臨床外科学会, Japanese - 99mTc‐GSAシンチグラフィーとCTの3D fusion画像が手術時期決定に有用であった胆嚢管癌の一例
敦賀陽介, 蒲池浩文, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 日本臨床外科学会雑誌, 76, 9, 2346, 2346, 25 Sep. 2015
日本臨床外科学会, Japanese - 肝細胞癌再発に対するアイエーコール動注+経口抗癌剤併用療法の治療成績
若山顕治, 神山俊哉, 横尾英樹, 柿坂達彦, 折茂達也, 敦賀陽介, 蒲池浩文, 武冨紹信, 作原祐介, 阿保大介, IVR, 30, 3, 268, 268, 20 Sep. 2015
(一社)日本インターベンショナルラジオロジー学会, Japanese - 99mTc‐GSAシンチグラフィーとCTの3D fusion画像を用いた機能的肝切除率の有用性の検討
敦賀陽介, 蒲池浩文, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, IVR, 30, 3, 271, 20 Sep. 2015
Japanese - 既存ドレーン経路と経皮的空腸瘻造設により経皮的に治療した膵液瘻の1例
阿保 大介, 吉野 裕紀, 高橋 文也, 曽山 武士, 作原 祐介, 工藤 與亮, 蒲池 浩文, 折茂 達也, 若山 顕治, 柿坂 達彦, 敦賀 陽介, 横尾 英樹, 神山 俊哉, IVR: Interventional Radiology, 30, 3, 271, 271, Sep. 2015
(一社)日本インターベンショナルラジオロジー学会, Japanese - Sorafenib導入後HCC症例に対する経動脈治療の検討
吉野 裕紀, 阿保 大介, 作原 祐介, 高橋 文也, 曽山 武士, 工藤 與亮, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 小川 浩司, 荘 拓也, 夏井坂 光輝, IVR: Interventional Radiology, 30, 3, 273, 273, Sep. 2015
(一社)日本インターベンショナルラジオロジー学会, Japanese - 当科における肝細胞癌に対する腹腔鏡下肝切除術の治療成績
柿坂 達彦, 神山 俊哉, 横尾 英樹, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本消化器外科学会総会, 70回, P, 55, Jul. 2015
(一社)日本消化器外科学会, Japanese - 世界へ発信する肝臓外科医療 高度脈管浸潤を伴う肝細胞癌に対する治療戦略
武冨 紹信, 若山 顕治, 柿坂 達彦, 折茂 達也, 敦賀 陽介, 横尾 英樹, 蒲池 浩文, 神山 俊哉, 日本消化器外科学会総会, 70回, SY, 4, Jul. 2015
(一社)日本消化器外科学会, Japanese - 肝切除術における手技・デバイスの工夫 横隔膜浸潤を伴う肝右葉巨大腫瘤に対する、LigaSureを用いた右横隔膜切除、肝右葉受動先行右系肝葉切除
若山 顕治, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 折茂 達也, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本消化器外科学会総会, 70回, RS, 69, Jul. 2015
(一社)日本消化器外科学会, Japanese - 肝内胆管癌に対するリンパ節郭清、肝外胆管切除の意義についての検討
折茂 達也, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本消化器外科学会総会, 70回, O, 53, Jul. 2015
(一社)日本消化器外科学会, Japanese - 下右肝静脈を温存し肝前区域切除+S7亜区域切除術で完全に病巣を切除し得た多包性肝エキノコックス症の1例
柴田 泰洋, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本消化器外科学会総会, 70回, P, 154, Jul. 2015
(一社)日本消化器外科学会, Japanese - BCLC Classification Stage B、C症例に対する肝切除の意義
神山 俊哉, 横尾 英樹, 柿坂 達彦, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本消化器外科学会総会, 70回, P, 192, Jul. 2015
(一社)日本消化器外科学会, Japanese - NBNC肝細胞癌に対する外科治療戦略
横尾 英樹, 神山 俊哉, 柿坂 達彦, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本消化器外科学会総会, 70回, P, 192, Jul. 2015
(一社)日本消化器外科学会, Japanese - ヒト肝細胞リソース樹立のための組織片処理法と培養条件の検討
深井原, 山下健一郎, 石川隆壽, 島田慎吾, 若山顕治, 柿坂達彦, 敦賀陽介, 折茂達也, 横尾英樹, 蒲池浩文, 神山俊哉, 武冨紹信, 嶋村剛, 北海道外科雑誌, 60, 1, 96, 96, 20 Jun. 2015
北海道外科学会, Japanese - 肝管空腸吻合から20年後にPetersen’s herniaを発症した1例
柏倉さゆり, 若山顕治, 折茂達也, 敦賀陽介, 柿坂達彦, 横尾英樹, 蒲池浩文, 神山俊哉, 武冨紹信, 北海道外科雑誌, 60, 1, 74, 74, 20 Jun. 2015
北海道外科学会, Japanese - 肝細胞癌と鑑別が困難であった多発肝血管筋脂肪腫の一例
太田拓児, 神山俊哉, 横尾英樹, 柿坂達彦, 折茂達也, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 北海道外科雑誌, 60, 1, 91, 91, 20 Jun. 2015
北海道外科学会, Japanese - A CASE OF HEPATIC ALVEOLAR ECHINOCOCCOSIS WITH COMPLETE OBSTRUCTION OF THE INFERIOR VENA CAVA
千田圭悟, 神山俊哉, 柿坂達彦, 横尾英樹, 畑中佳奈子, 武冨紹信, 日本臨床外科学会雑誌, 76, 5, 1124, 1129, 25 May 2015
日本臨床外科学会, Japanese - 自己免疫性膵炎に合併した胆嚢IgG4関連炎症性偽腫瘍の1例
敦賀 陽介, 蒲池 浩文, 三橋 智子, 田原 宗徳, 若山 顕治, 折茂 達也, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 武冨 紹信, 日本消化器外科学会雑誌, 48, 5, 414, 420, May 2015
(一社)日本消化器外科学会, Japanese - 予後再発因子から見た肝内胆管癌の治療戦略
横尾英樹, 神山俊哉, 柿坂達彦, 折茂達也, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 肝臓, 56, Supplement 1, A510, A510, 20 Apr. 2015
(一社)日本肝臓学会, Japanese - 非B非C型肝細胞癌に対する肝切除症例の検討
折茂達也, 神山俊哉, 横尾英樹, 柿坂達彦, 若山顕治, 武冨紹信, 肝臓, 56, Supplement 1, A277, A277, 20 Apr. 2015
(一社)日本肝臓学会, Japanese - わかりやすい消化器癌治療のコンセンサス III 大腸癌の診断と治療 大腸癌肝転移に対する治療戦略 外科治療
折茂達也, 神山俊哉, 横尾英樹, 柿坂達彦, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 消化器外科, 38, 5, 665, 669, 20 Apr. 2015
(株)へるす出版, Japanese - 高度脈管(門脈,肝静脈,胆管)侵襲を伴う肝細胞癌に対する治療戦略 肝胆膵 vp3,4肝細胞癌の門脈腫瘍栓に対する術前放射線治療の有効性の検討
柿坂 達彦, 神山 俊哉, 横尾 英樹, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本外科学会定期学術集会抄録集, 115回, PD, 6, Apr. 2015
(一社)日本外科学会, Japanese - AFP産生大腸癌同時性肝転移に対しConversion therapyを行いR0切除しえた1例
吉田祐一, 本間重紀, 柴崎晋, 吉田雅, 川村秀樹, 高橋典彦, 若山顕治, 折茂達也, 柿坂達彦, 敦賀陽介, 横尾秀樹, 蒲池浩文, 神山俊哉, 武冨紹信, 日本大腸こう門病学会雑誌, 68, 3, 202, 202, Mar. 2015
(一社)日本大腸肛門病学会, Japanese - 肝癌の治療 外科的治療 大腸癌同時性肝転移の腹腔鏡下肝切除
神山俊哉, 本間重紀, 柿坂達彦, 皆川のぞみ, 武冨紹信, 日本臨床, 73, 増刊1 最新肝癌学, 699, 703, 20 Jan. 2015
(株)日本臨床社, Japanese - Effect of high expression of fatty acid binding protein 5 on prognosis and epithelial-mesenchymal transition in hepatocellular carcinoma
Takanori Ohata, Hideki Yokoo, Toshiya Kamiyama, Takeshi Aiyama, Kenji Wakayama, Tatsuya Orimo, Tatsuhiko Kakisaka, Yousuke Tsuruga, Hirofumi Kamachi, Akinobu Taketomi, JOURNAL OF CLINICAL ONCOLOGY, 33, 3, Jan. 2015
English, Summary international conference - A resected case of mixed ductal-neuroendocrine carcinoma of the pancreas
Kazuaki Shibuya, Hirofumi Kamachi, Yousuke Tsuruga, Kenji Wakayama, Tatsuya Orimo, Tatsuhiko Kakisaka, Hideki Yokoo, Toshiya Kamiyama, Tomoko Mitsuhashi, Akinobu Taketomi, Japanese Journal of Gastroenterological Surgery, 48, 4, 337, 343, 2015
Japanese Society of Gastroenterological Surgery, Japanese - 肝癌細胞株における浸潤能と糖鎖異常の解析
高橋秀徳, 柿坂達彦, 神山俊哉, 相山健, 島田慎吾, 若山顕治, 折茂達也, 敦賀陽介, 蒲池浩文, 横尾英樹, 田中誠一, 西村紳一郎, 武冨紹信, 日本癌治療学会学術集会(Web), 53rd, 3, P131‐1 (WEB ONLY), 2491, 2015
(一社)日本癌治療学会, Japanese - 胆管内腫瘍栓を伴う肝細胞癌に対する肝切除症例の検討
折茂達也, 神山俊哉, 横尾英樹, 柿坂達彦, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本消化器病学会大会(Web), 57th, Suppl.2, GEP‐199 (WEB ONLY), 182, 2015
(一社)日本消化器外科学会, Japanese - 肝細胞癌におけるAdenomatous polyposis coli結合蛋白EB1と浸潤の関連性
相山健, 横尾英樹, 折茂達也, 大畑多嘉宣, 柿坂達彦, 畑中佳奈子, 畑中豊, 松野吉宏, 高橋秀徳, 若山顕治, 敦賀陽介, 蒲池浩文, 神山俊哉, 武冨紹信, 日本消化器癌発生学会総会プログラム・抄録集, 26th, 68, 2015
Japanese - 肝細胞癌における癌幹細胞マーカーCD44およびCD133発現の意義
高橋秀徳, 相山健, 神山俊哉, 佐々木彩実, 畑中佳奈子, 松野吉宏, 大畑多嘉宣, 若山顕治, 折茂達也, 柿坂達彦, 敦賀陽介, 蒲池浩文, 横尾英樹, 武冨紹信, 日本外科学会定期学術集会(Web), 115th, OP-077-4 (WEB ONLY), 4, 2015
(一社)日本外科学会, Japanese - Peritumoral steatosisを伴う多発肝転移を呈した膵神経内分泌腫瘍の一例
近藤享史, 蒲池浩文, 敦賀陽介, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 日本外科学会定期学術集会(Web), 115th, RS-19-9 (WEB ONLY), 9, 2015
(一社)日本外科学会, Japanese - 同時性肝転移を伴った大腸癌に対する腹腔鏡下大腸・肝同時切除の安全性
吉田雅, 本間重紀, 柴崎晋, 下國達志, 崎浜秀康, 高橋典彦, 高橋典彦, 川村秀樹, 柿坂達彦, 神山俊哉, 武冨紹信, 大腸癌研究会プログラム・抄録集, 83rd, 85, 2015
Japanese - A resected case of mixed ductal-neuroendocrine carcinoma of the pancreas
Kazuaki Shibuya, Hirofumi Kamachi, Yousuke Tsuruga, Kenji Wakayama, Tatsuya Orimo, Tatsuhiko Kakisaka, Hideki Yokoo, Toshiya Kamiyama, Tomoko Mitsuhashi, Akinobu Taketomi, Japanese Journal of Gastroenterological Surgery, 48, 4, 337, 343, 2015
Japanese Society of Gastroenterological Surgery, Japanese - 大腸癌同時性肝転移に対する一期的腹腔鏡下肝・大腸切除術
神山俊哉, 横尾英樹, 柿坂達彦, 折茂達也, 若山顕治, 蒲池浩文, 敦賀陽介, 本間重紀, 柴崎晋, 吉田雅, 武冨紹信, 日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM), 27th, ROMBUNNO.ORS16-6, 469, 2015
(一社)日本肝胆膵外科学会, Japanese - 下大静脈,右心房に腫瘍栓を伴う肝細胞癌に対する治療戦略
若山顕治, 神山俊哉, 横尾英樹, 柿坂達彦, 折茂達也, 蒲池浩文, 敦賀陽介, 嶋村剛, 武冨紹信, 日本外科学会定期学術集会(Web), 115th, PD-10-4 (WEB ONLY), 4, 2015
(一社)日本外科学会, Japanese - 大腸癌多発肝転移に対する下右肝静脈灌流領域を評価した術前プランニング
横尾英樹, 神山俊哉, 柿坂達彦, 折茂達哉, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM), 27th, ROMBUNNO.P56-5, 586, 2015
(一社)日本肝胆膵外科学会, Japanese - 肝門部領域胆管癌における門脈塞栓の適応と成績
蒲池浩文, 敦賀陽介, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM), 27th, ROMBUNNO.ORS3-5, 450, 2015
(一社)日本肝胆膵外科学会, Japanese - 肝細胞癌におけるAdenomatous polyposis coli結合蛋白EB1の新規バイオマーカーとしての可能性
相山健, 横尾英樹, 折茂達也, 大畑多嘉宣, 畑中佳奈子, 畑中豊, 松野吉宏, 高橋秀徳, 若山顕治, 柿坂達彦, 敦賀陽介, 蒲池浩文, 神山俊哉, 武冨紹信, 日本外科学会定期学術集会(Web), 115th, OP-160-1 (WEB ONLY), 1, 2015
(一社)日本外科学会, Japanese - 肝細胞癌再発に対するアイエーコール動注+UFT経口併用療法
若山顕治, 神山俊哉, 横尾英樹, 柿坂達彦, 折茂達也, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM), 27th, ROMBUNNO.P71-7, 612, 2015
(一社)日本肝胆膵外科学会, Japanese - 肝切除術後胆管狭窄に対する皮下埋め込み式胆道内瘻術
折茂達也, 神山俊哉, 横尾英樹, 柿坂達彦, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM), 27th, ROMBUNNO.MWS4-6, 435, 2015
(一社)日本肝胆膵外科学会, Japanese - 下大静脈閉塞を伴った多包性肝エキノコックス症の1例
千田圭悟, 神山俊哉, 横尾英樹, 柿坂達彦, 折茂達也, 若山顕治, 敦賀陽介, 蒲池浩文, 畑中佳奈子, 武冨紹信, 日本外科学会定期学術集会(Web), 115th, RS-15-7 (WEB ONLY), 7, 2015
(一社)日本外科学会, Japanese - IgG4-related inflammatory pseudotumor of the gallbladder associated with autoimmune pancreatitis
Yosuke Tsuruga, Hirohumi Kamachi, Tomoko Mitsuhashi, Munenori Tahara, Kenji Wakayama, Tatsuya Orimo, Tatsuhiko Kakisaka, Hideki Yokoo, Toshiya Kamiyama, Akinobu Taketomi, Japanese Journal of Gastroenterological Surgery, 48, 5, 414, 420, 2015
Japanese Society of Gastroenterological Surgery, Japanese - 肝細胞癌に対する無水エタノールを用いた術前門脈塞栓術の検討
柿坂達彦, 神山俊哉, 横尾英樹, 折茂達也, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM), 27th, ROMBUNNO.P3-3, 493, 2015
(一社)日本肝胆膵外科学会, Japanese - 肝門部胆管癌左葉系切除におけるTransparenchymal glissonean approach(TGA)による手術限界
蒲池浩文, 敦賀陽介, 若山顕治, 折茂達也, 柿坂達彦, 後藤了一, 山下健一郎, 神山俊哉, 武冨紹信, 日本外科学会定期学術集会(Web), 115th, SY-7-3 (WEB ONLY), 3, 2015
(一社)日本外科学会, Japanese - 当科における解剖学的肝切除手技の定型化と治療成績の検討
折茂達也, 神山俊哉, 横尾英樹, 柿坂達彦, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本外科学会定期学術集会(Web), 115th, OP-074-1 (WEB ONLY), 1, 2015
(一社)日本外科学会, Japanese - 正中弓状靭帯症候群を合併した下膵十二指腸動脈瘤2例の治療経験
加藤拓也, 蒲池浩文, 敦賀陽介, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 神山俊哉, 若狭哲, 大岡智学, 阿保大介, 作原祐介, 松居喜郎, 武冨紹信, 日本外科学会定期学術集会(Web), 115th, RS-19-7 (WEB ONLY), 7, 2015
(一社)日本外科学会, Japanese - 膵癌術前放射線化学療法における術前胆道ドレナージ法の検討
敦賀陽介, 蒲池浩文, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM), 27th, ROMBUNNO.P80-2, 8, 2015
(一社)日本消化器外科学会, Japanese - 99mTc‐GSAシンチグラフィーとCTの3D fusion画像を用いた残肝機能予測
敦賀陽介, 蒲池浩文, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 日本外科学会定期学術集会(Web), 115th, OP-166-1 (WEB ONLY), 1, 2015
(一社)日本外科学会, Japanese - 下膵十二指腸動脈瘤に正中弓状靭帯症候群を合併した2例の治療経験
加藤拓也, 蒲池浩文, 敦賀陽介, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 若狭哲, 大岡智学, 阿保大介, 作原祐介, 北海道外科雑誌, 59, 2, 190, 190, 20 Dec. 2014
北海道外科学会, Japanese - S8c肝細胞癌に対する腹腔鏡下肝切除の工夫
坂本聡大, 神山俊哉, 横尾英樹, 柿坂達彦, 折茂達也, 若山顕治, 加藤拓也, 敦賀陽介, 蒲池浩文, 武冨紹信, 北海道外科雑誌, 59, 2, 179, 180, 20 Dec. 2014
北海道外科学会, Japanese - バイパス術後にIVRにて治療し得た未破裂膵十二指腸動脈瘤の1例
木井修平, 蒲池浩文, 敦賀陽介, 若山顕治, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 阿保大介, 若狭哲, IVR, 29, 4, 426, 426, 01 Dec. 2014
(一社)日本インターベンショナルラジオロジー学会, Japanese - 大腸癌肝転移切除における術中造影USの有用性
若山顕治, 神山俊哉, 横尾英樹, 柿坂達彦, 折茂達也, 蒲池浩文, 敦賀陽介, 武冨紹信, IVR, 29, 4, 429, 429, 01 Dec. 2014
(一社)日本インターベンショナルラジオロジー学会, Japanese - 外科切除適応の境界領域―Borderline resectable cancerへの対応 がん種別の治療指針 肝癌
柿坂達彦, 神山俊哉, 若山顕治, 横尾英樹, 折茂達也, 敦賀陽介, 蒲池浩文, 山下健一郎, 嶋村剛, 武冨紹信, 臨床外科, 69, 12, 1351, 1356, 20 Nov. 2014
(株)医学書院, Japanese - 肝細胞癌再発に対するアイエーコール動注+経口抗癌剤併用療法
若山 顕治, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 折茂 達也, 敦賀 陽介, 蒲池 浩文, 曽山 武士, 作原 祐介, 阿保 大介, 武冨 紹信, 癌と化学療法, 41, 12, 1503, 1505, Nov. 2014
(株)癌と化学療法社, Japanese - 肝胆膵領域における術前ストラテジー I.総論 4.門脈圧亢進症合併肝癌の術前管理
敦賀陽介, 神山俊哉, 折茂達也, 若山顕治, 柿坂達彦, 横尾英樹, 蒲池浩文, 武冨紹信, 外科, 76, 11, 1223, 1226, 01 Nov. 2014
(株)南江堂, Japanese - 臍静脈Patch graft再建により切除し得た下大静脈原発平滑筋肉腫の一例
深作慶友, 神山俊哉, 横尾英樹, 柿坂達彦, 折茂達也, 若山顕治, 蒲地浩文, 敦賀陽介, 武冨紹信, 日本臨床外科学会雑誌, 75, 増刊, 734, 734, 20 Oct. 2014
日本臨床外科学会, Japanese - Conversion therapyによりR0切除しえたAFP産生大腸癌同時性肝転移の一例
沢田尭史, 本間重紀, 柴崎晋, 吉田雅, 川村秀樹, 高橋典彦, 若山顕治, 折茂達也, 柿坂達彦, 敦賀陽介, 横尾英樹, 蒲池浩文, 神山俊哉, 武冨紹信, 日本臨床外科学会雑誌, 75, 増刊, 570, 570, 20 Oct. 2014
日本臨床外科学会, Japanese - 肝細胞癌におけるFABP5発現の意義
大畑 多嘉宣, 横尾 英樹, 神山 俊哉, 若山 顕治, 折茂 達也, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本消化器外科学会雑誌, 47, Suppl.2, 218, 218, Oct. 2014
(一社)日本消化器外科学会, Japanese - 出血性嚢胞との鑑別が困難だった胆管MCNの一例
大平将史, 神山俊哉, 蒲池浩文, 横尾英樹, 柿坂達彦, 敦賀陽介, 折茂達也, 若山顕治, 武冨紹信, 日本臨床外科学会雑誌, 75, 9, 2641, 2641, 25 Sep. 2014
日本臨床外科学会, Japanese - 下大静脈/右心房腫瘍栓を伴う高度進行肝細胞癌に対する外科的治療
若山顕治, 神山俊哉, 横尾英樹, 柿坂達彦, 蒲池浩文, 敦賀陽介, 山下健一郎, 嶋村剛, 武冨紹信, 日本臨床外科学会雑誌, 75, 9, 2628, 2628, 25 Sep. 2014
日本臨床外科学会, Japanese - 膵Mixed ductal‐neuroendocrine carcinomaの1例
渋谷一陽, 蒲池浩文, 敦賀陽介, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 日本臨床外科学会雑誌, 75, 9, 2642, 2642, 25 Sep. 2014
日本臨床外科学会, Japanese - エリスロポエチン産生による多血症を伴った巨大肝細胞癌の1例
加藤紘一, 神山俊哉, 横尾英樹, 柿坂達彦, 折茂達也, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本臨床外科学会雑誌, 75, 9, 2647, 2647, 25 Sep. 2014
日本臨床外科学会, Japanese - 膵癌術後難治性下痢に対してポリカルボフィルカルシウム(ポリフル)が有効であった1例
正司裕隆, 蒲池浩文, 敦賀陽介, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 日本臨床外科学会雑誌, 75, 9, 2648, 2649, 25 Sep. 2014
日本臨床外科学会, Japanese - 肝細胞癌腹腔鏡下術後に早期腹膜播種再発をおこした1例
加藤紘一, 神山俊哉, 横尾英樹, 柿坂達彦, 折茂達也, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本臨床外科学会雑誌, 75, 9, 2639, 2639, 25 Sep. 2014
日本臨床外科学会, Japanese - 見逃すな,寄生虫感染症!発症すると治療が困難な寄生虫感染症 多包性エキノコックス症
佐藤直樹, 柿坂達彦, 敦賀陽介, 武冨紹信, 臨床と微生物, 41, 4, 359, 366, 25 Jul. 2014
(株)近代出版, Japanese - 術後合併症への対処法Surgical vs Non‐Surgical―いつどのように判断するか?肝胆膵領域 肝胆道切除後出血への対処法
横尾英樹, 神山俊哉, 柿坂達彦, 折茂達也, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 臨床外科, 69, 7, 834, 839, 20 Jul. 2014
(株)医学書院, Japanese - 大腸癌原発巣および肝転移巣に対する腹腔鏡下同時切除術の検討
正司裕隆, 神山俊哉, 皆川のぞみ, 柴崎晋, 若山顕治, 折茂達也, 敦賀陽介, 柿坂達彦, 本間重紀, 横尾秀樹, 蒲池浩文, 川村秀樹, 高橋典彦, 武冨紹信, 日本大腸こう門病学会雑誌, 67, 7, 491, 491, Jul. 2014
(一社)日本大腸肛門病学会, Japanese - 特異な画像所見を示し診断に苦慮した肝内胆管癌再発の1例
金沢亮, 蒲池浩文, 敦賀陽介, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 北海道外科雑誌, 59, 1, 64, 65, 20 Jun. 2014
北海道外科学会, Japanese - Overexpression of fatty acid binding protein 5 and tumorigenesis in hepatocellular carcinoma.
Takanori Ohata, Hideki Yokoo, Toshiya Kamiyama, Kenji Wakayama, Tatsuya Orimo, Tatsuhiko Kakisaka, Yousuke Tsuruga, Hirofumi Kamachi, Akinobu Taketomi, JOURNAL OF CLINICAL ONCOLOGY, 32, 15, May 2014
English, Summary international conference - PS-157-7 肝細胞癌における循環腫瘍細胞ならびに骨髄腫瘍細胞と臨床病理組織学的因子の検討(PS-157 肝 肝細胞癌-4,ポスターセッション,第114回日本外科学会定期学術集会)
皆川 のぞみ, 崎浜 秀康, 小林 希, 小原 美都, 柴崎 晋, 若山 顕治, 折茂 達也, 柿坂 達彦, 敦賀 陽介, 本間 重紀, 横尾 秀樹, 蒲池 浩文, 川村 秀樹, 高橋 典彦, 神山 俊哉, 武冨 紹信, 日本外科学会雑誌, 115, 2, 889, 889, 05 Mar. 2014
一般社団法人日本外科学会, Japanese - OP-009-7 Borderline resectable膵癌に対するゲムシタビン併用術前放射線化学療法の治療効果(OP-009 膵 膵癌-1,一般演題,第114回日本外科学会定期学術集会)
敦賀 陽介, 蒲池 浩文, 若山 顕治, 折茂 達也, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 武冨 紹信, 日本外科学会雑誌, 115, 2, 328, 328, 05 Mar. 2014
一般社団法人日本外科学会, Japanese - OP-054-2 腹腔鏡下肝葉切除における肝門部処理・肝実質切離の基本的手技の確立(OP-054 肝 内視鏡下-2,一般演題,第114回日本外科学会定期学術集会)
神山 俊哉, 横尾 英樹, 柿坂 達彦, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本外科学会雑誌, 115, 2, 411, 411, 05 Mar. 2014
一般社団法人日本外科学会, Japanese - OP-024-1 肝門部胆管癌における動脈再建症例の検討(OP-024 胆 悪性 胆道癌-1,一般演題,第114回日本外科学会定期学術集会)
蒲池 浩文, 敦賀 陽介, 若山 顕治, 折茂 達也, 柿坂 達彦, 横尾 英樹, 後藤 了一, 山下 健一郎, 神山 俊哉, 武冨 紹信, 日本外科学会雑誌, 115, 2, 355, 355, 05 Mar. 2014
一般社団法人日本外科学会, Japanese - OP-099-5 肝細胞癌におけるFABP5の新規バイオマーカーとしての有用性(OP-099 肝 肝細胞癌-1,一般演題,第114回日本外科学会定期学術集会)
大畑 多嘉宣, 横尾 英樹, 神山 俊哉, 若山 顕治, 折茂 達也, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本外科学会雑誌, 115, 2, 490, 490, 05 Mar. 2014
一般社団法人日本外科学会, Japanese - PS-008-2 混合型肝癌15例の臨床病理学的検討(PS-008 肝 その他-2,ポスターセッション,第114回日本外科学会定期学術集会)
柿坂 達彦, 神山 俊哉, 横尾 英樹, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本外科学会雑誌, 115, 2, 590, 590, 05 Mar. 2014
一般社団法人日本外科学会, Japanese - PS-008-8 大腸癌多発肝転移に対するベストな外科治療戦略(PS-008 肝 その他-2,ポスターセッション,第114回日本外科学会定期学術集会)
横尾 英樹, 神山 俊哉, 柿坂 達彦, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本外科学会雑誌, 115, 2, 591, 591, 05 Mar. 2014
一般社団法人日本外科学会, Japanese - PS-080-3 肝切除術における術前腸管処置のSSI発生に及ぼす影響(PS-080 肝 周術期管理,ポスターセッション,第114回日本外科学会定期学術集会)
折茂 達也, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 若山 顕治, 敦賀 陽介, 鎌池 浩文, 武冨 紹信, 日本外科学会雑誌, 115, 2, 734, 734, 05 Mar. 2014
一般社団法人日本外科学会, Japanese - 大腸癌多発肝転移に対するベストな外科治療戦略
横尾英樹, 神山俊哉, 柿坂達彦, 折茂達也, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本外科学会雑誌, 115, 臨増2, 591, 591, 05 Mar. 2014
(一社)日本外科学会, Japanese - 腹腔鏡下肝葉切除における肝門部処理・肝実質切離の基本的手技の確立
神山俊哉, 横尾英樹, 柿坂達彦, 折茂達也, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本外科学会雑誌, 115, 臨増2, 411, 411, 05 Mar. 2014
(一社)日本外科学会, Japanese - 肝切除術における術前腸管処置のSSI発生に及ぼす影響
折茂達也, 神山俊哉, 横尾英樹, 柿坂達彦, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本外科学会雑誌, 115, 臨増2, 734, 734, 05 Mar. 2014
(一社)日本外科学会, Japanese - 混合型肝癌15例の臨床病理学的検討
柿坂達彦, 神山俊哉, 横尾英樹, 折茂達也, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本外科学会雑誌, 115, 臨増2, 590, 590, 05 Mar. 2014
(一社)日本外科学会, Japanese - Borderline resectable膵癌に対するゲムシタビン併用術前放射線化学療法の治療効果
敦賀陽介, 蒲池浩文, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 日本外科学会雑誌, 115, 臨増2, 328, 328, 05 Mar. 2014
(一社)日本外科学会, Japanese - 肝細胞癌における循環腫瘍細胞ならびに骨髄腫瘍細胞と臨床病理組織学的因子の検討
皆川のぞみ, 崎浜秀康, 小林希, 小原美都, 柴崎晋, 若山顕治, 折茂達也, 柿坂達彦, 敦賀陽介, 本間重紀, 横尾秀樹, 蒲池浩文, 川村秀樹, 高橋典彦, 神山俊哉, 武冨紹信, 日本外科学会雑誌, 115, 臨増2, 889, 889, 05 Mar. 2014
(一社)日本外科学会, Japanese - 肝細胞癌におけるFABP5の新規バイオマーカーとしての有用性
大畑多嘉宣, 横尾英樹, 神山俊哉, 若山顕治, 折茂達也, 柿坂達彦, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本外科学会雑誌, 115, 臨増2, 490, 490, 05 Mar. 2014
(一社)日本外科学会, Japanese - 肝門部胆管癌における動脈再建症例の検討
蒲池浩文, 敦賀陽介, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 後藤了一, 山下健一郎, 神山俊哉, 武冨紹信, 日本外科学会雑誌, 115, 臨増2, 355, 355, 05 Mar. 2014
(一社)日本外科学会, Japanese - 脾のSANT(Sclerosing Angiomatoid Nodular Transformation)の2例
HARADA TAISUKE, KATO FUMI, KIKUCHI YASUKA, MIMURA RIE, MANABE TOKUKO, ONODERA YUYA, TERAE SATOSHI, KAKISAKA TATSUHIKO, WAKAYAMA KENJI, YOKOO HIDEKI, KAMIYAMA TOSHIYA, TAKAKUWA EMI, YAMADA YOSUKE, MITSUHASHI TOMOKO, SHIRATO HIROKI, Jpn J Radiol, 32, Suppl., 12, 12, Feb. 2014
(公社)日本医学放射線学会, Japanese - An inflammatory myofibroblastic tumor of the liver evaluated by contrast-enhanced ultrasonography
Satomi Omotehara, Mutsumi Nishida, Yusuke Kudoh, Chikara Shimizu, Satomi Omotehara, Mutsumi Nishida, Megumi Satoh, Yusuke Kudoh, Megumi Satoh, Yusuke Sakuhara, Tomoko Mitsuhashi, Tatsuhiko Kakisaka, Hideki Yokoo, Toshiya Kamiyama, choonpa igaku, 41, 2, 225, 232, 01 Feb. 2014
The Japan Society of Ultrasonics in Medicine, English - 大腸癌原発巣および肝転移巣に対する腹腔鏡下同時切除術の検討
正司裕隆, 神山俊哉, 皆川のぞみ, 柴崎晋, 若山顕治, 折茂達也, 敦賀陽介, 柿坂達彦, 本間重紀, 横尾秀樹, 蒲池浩文, 川村秀樹, 高橋典彦, 武冨紹信, 日本大腸こう門病学会雑誌, 67, 2, 109, 109, Feb. 2014
(一社)日本大腸肛門病学会, Japanese - Adenomatous polyposis coli-binding protein EB1 as an important predictive factor for the prognosis and recurrence in hepatocellular carcinoma
Takeshi Aiyama, Tatsuya Orimo, Hideki Yokoo, Takanori Ohata, Kanako Hatanaka, Yutaka Hatanaka, Yoshihiro Matsuno, Kenji Wakayama, Tatsuhiko Kakisaka, Yosuke Tsuruga, Hirofumi Kamachi, Toshiya Kamiyama, Akinobu Taketomi, HEPATOLOGY, 60, 802A, 802A, 2014
English, Summary international conference - Fatty Acid Binding Protein 5 promotes tumor progression through epithelial-mesenchymal transition in hepatocellular carcinoma
Takanori Ohata, Hideki Yokoo, Toshiya Kamiyama, Kenji Wakayama, Tatsuya Orimo, Tatsuhiko Kakisaka, Yosuke Tsuruga, Hirofumi Kamachi, Akinobu Taketomi, HEPATOLOGY, 60, 804A, 805A, 2014
English, Summary international conference - 間質性肺炎を合併した同時性大腸癌肝転移に対して2期的にそれぞれ腹腔鏡手術を施行しえた一例
石川 隆壽, 本間 重紀, 正司 裕隆, 柴崎 晋, 皆川 のぞみ, 川村 秀樹, 高橋 典彦, 柿坂 達彦, 神山 俊哉, 武冨 紹信, 日本内視鏡外科学会雑誌, 18, 7, 612, 612, Nov. 2013
(一社)日本内視鏡外科学会, Japanese - 大腸癌原発巣および肝転移巣に対する腹腔鏡下同時切除術の検討
皆川 のぞみ, 神山 俊哉, 柴崎 晋, 若山 顕治, 折茂 達也, 敦賀 陽介, 柿坂 達彦, 本間 重紀, 横尾 秀樹, 蒲池 浩文, 川村 秀樹, 高橋 典彦, 武冨 紹信, 日本内視鏡外科学会雑誌, 18, 7, 708, 708, Nov. 2013
(一社)日本内視鏡外科学会, Japanese - 腫瘍栓により門脈本幹が完全閉塞した肝細胞癌に対するpassive bypassを使用した肝右葉切除術
折茂達也, 神山俊哉, 横尾英樹, 柿坂達彦, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本臨床外科学会雑誌, 74, 増刊, 561, 561, 20 Oct. 2013
日本臨床外科学会, Japanese - 自己免疫性膵炎に合併した胆嚢IgG4関連炎症性偽腫瘍の一例
敦賀陽介, 蒲池浩文, 三橋智子, 若山顕治, 折茂達也, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 日本臨床外科学会雑誌, 74, 増刊, 696, 696, 20 Oct. 2013
日本臨床外科学会, Japanese - 腹腔鏡下肝切除における基本的手技:実質切離・肝門部・短肝静脈処理の確立
神山俊哉, 横尾英樹, 柿坂達彦, 折茂達也, 若山顕治, 蒲池浩文, 敦賀陽介, 武冨紹信, 日本臨床外科学会雑誌, 74, 増刊, 525, 525, 20 Oct. 2013
日本臨床外科学会, Japanese - 多発性肝嚢胞に対して肝拡大左葉切除術を施行した1例
柿坂達彦, 神山俊哉, 横尾英樹, 折茂達也, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本臨床外科学会雑誌, 74, 増刊, 562, 562, 20 Oct. 2013
日本臨床外科学会, Japanese - V4bを温存した中肝静脈合併切除を要する肝拡大右葉切除術~三次元画像解析システムを用いた術前シミュレーションと術式の選択~
若山顕治, 神山俊哉, 柿坂達彦, 横尾英樹, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本臨床外科学会雑誌, 74, 増刊, 531, 531, 20 Oct. 2013
日本臨床外科学会, Japanese - 大腸癌肝転移切除における術中造影超音波検査の有用性
横尾英樹, 神山俊哉, 柿坂達彦, 折茂達也, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本臨床外科学会雑誌, 74, 増刊, 561, 561, 20 Oct. 2013
日本臨床外科学会, Japanese - AFPとPIVKA-IIの積=AP値の肝細胞癌切除例における術前予後・再発予測因子としての意義
神山 俊哉, 横尾 英樹, 柿坂 達彦, 若山 顕治, 蒲池 浩文, 敦賀 陽介, 武冨 紹信, 日本消化器外科学会雑誌, 46, Suppl.2, 148, 148, Oct. 2013
(一社)日本消化器外科学会, Japanese - vp3、4肝細胞癌の門脈腫瘍栓に対する術前放射線治療の有効性の検討
柿坂 達彦, 神山 俊哉, 横尾 英樹, 折茂 達也, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本消化器外科学会雑誌, 46, Suppl.2, 154, 154, Oct. 2013
(一社)日本消化器外科学会, Japanese - 予後向上に向けた肝内胆管癌に対する術後補助化学療法
横尾 英樹, 神山 俊哉, 柿坂 達彦, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本消化器外科学会雑誌, 46, Suppl.2, 154, 154, Oct. 2013
(一社)日本消化器外科学会, Japanese - 胆嚢癌との鑑別を要した黄色肉芽腫性胆嚢炎の3切除例
敦賀 陽介, 蒲池 浩文, 若山 顕治, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 武冨 紹信, 日本消化器外科学会雑誌, 46, Suppl.2, 216, 216, Oct. 2013
(一社)日本消化器外科学会, Japanese - A product of alpha-fetoprotein and protein induced by vitamin K absence-II as a powerful predictor of the prognosis and recurrence of hepatocellular carcinoma after hepatectomy
Toshiya Kamiyama, Hideki Yokoo, Tatsuhiko Kakisaka, Tatsuya Orimo, Kenji Wakayama, Hirofumi Kamachi, Yosuke Tsuruga, Kenichiro Yamashita, Tsuyoshi Shimamura, Satoru Todo, Akinobu Taketomi, HEPATOLOGY, 58, 1250A, 1250A, Oct. 2013
English, Summary international conference - 肝細胞癌における循環腫瘍細胞ならびに骨髄腫瘍細胞と臨床病理組織学的因子の関連性(Cellular detection of circulating tumor cells and disseminated tumor cells of patients with hepatocellular carcinoma)
皆川 のぞみ, 崎浜 秀康, 小林 希, 若山 顕治, 折茂 達也, 柿坂 達彦, 敦賀 陽介, 本間 重紀, 横尾 秀樹, 蒲池 浩文, 高橋 典彦, 神山 俊哉, 武冨 紹信, 日本癌学会総会記事, 72回, 179, 179, Oct. 2013
日本癌学会, English - 肝尾状葉腫瘍切除における3次元画像解析システムの有用性
若山顕治, 敦賀陽介, 柿坂達彦, 横尾英樹, 蒲池浩文, 神山俊哉, 武冨紹信, IVR, 28, 4, 487, 487, 01 Oct. 2013
(一社)日本インターベンショナルラジオロジー学会, Japanese - Portal vein stenosis after pancreatectomy following neoadjuvant chemoradiation therapy for pancreatic cancer
敦賀 陽介, 蒲池 浩文, 若山 顕治, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 武冨 紹信, 北海道醫學雜誌 = Acta medica Hokkaidonensia, 88, 4, 150, 150, 01 Sep. 2013
Japanese - 開腹肝切除後の肝細胞癌再発に対して腹腔鏡下肝部分切除を施行した1例
石川隆壽, 神山俊哉, 蒲池浩文, 横尾英樹, 敦賀陽介, 柿坂達彦, 若山顕治, 武冨紹信, 北海道外科雑誌, 58, 1, 83, 84, 20 Jun. 2013
北海道外科学会, Japanese - 腹腔鏡下胆嚢摘出術術後胆管閉塞に対し磁石圧迫吻合術にて再開通させた1例
敦賀陽介, 蒲池浩文, 若山顕治, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 齋藤博哉, 阿保大介, 北海道外科雑誌, 58, 1, 78, 78, 20 Jun. 2013
北海道外科学会, Japanese - Treatment for hepatocellular carcinoma
ORIMO TATSUYA, KAMIYAMA TOSHIYA, YOKOO HIDEKI, KAKISAKA TATSUHIKO, WAKAYAMA KENJI, TSURUGA YOSUKE, KAMACHI HIROFUMI, TAKETOMI AKINOBU, 北海道外科雑誌, 58, 1, 2, 6, 20 Jun. 2013
Japanese - SY-13-6 肝門部領域胆道系腫瘍に対する胆管・血管3DCT合成画像の治療戦略上の位置づけ(SY シンポジウム,第113回日本外科学会定期学術集会)
蒲池 浩文, 敦賀 陽介, 若山 顕治, 柿坂 達彦, 横尾 英樹, 山下 健一郎, 神山 俊哉, 武冨 紹信, 日本外科学会雑誌, 114, 2, 146, 146, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - VSY-15-6 3D画像支援システムによる下右肝静脈還流領域を評価した肝切除(VSY ビデオシンポジウム,第113回日本外科学会定期学術集会)
横尾 英樹, 神山 俊哉, 柿坂 達彦, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本外科学会雑誌, 114, 2, 211, 211, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - VSY-12-2 適応拡大を目指した腹腔鏡下肝切除における肝門部処理・肝実質切離法の確立(VSY ビデオシンポジウム,第113回日本外科学会定期学術集会)
神山 俊哉, 横尾 英樹, 柿坂 達彦, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本外科学会雑誌, 114, 2, 201, 201, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - PS-088-1 肝細胞癌における予後再発因子としてのFABP5発現の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)
大畑 多嘉宣, 横尾 英樹, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 神山 俊哉, 武富 紹信, 日本外科学会雑誌, 114, 2, 642, 642, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - PS-229-6 膵癌門脈合併切除術後門脈狭窄に対するステント留置の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)
敦賀 陽介, 蒲池 浩文, 若山 顕治, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 武冨 紹信, 日本外科学会雑誌, 114, 2, 841, 841, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - PS-352-1 vp3,4肝細胞癌の門脈腫瘍栓に対する術前放射線治療の有効性の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)
柿坂 達彦, 神山 俊哉, 横尾 英樹, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本外科学会雑誌, 114, 2, 1013, 1013, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - PS-093-3 肝細胞癌における血中遊離癌細胞と骨髄癌細胞の同定の試み(PS ポスターセッション,第113回日本外科学会定期学術集会)
皆川 のぞみ, 崎浜 秀康, 小林 希, 若山 顕治, 柿坂 達彦, 敦賀 陽介, 下國 達志, 本間 重紀, 横尾 秀樹, 蒲池 浩文, 高橋 典彦, 神山 俊哉, 武冨 紹信, 日本外科学会雑誌, 114, 2, 649, 649, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - SY-13-6 肝門部領域胆道系腫瘍に対する胆管・血管3DCT合成画像の治療戦略上の位置づけ(SY シンポジウム,第113回日本外科学会定期学術集会)
蒲池 浩文, 敦賀 陽介, 若山 顕治, 柿坂 達彦, 横尾 英樹, 山下 健一郎, 神山 俊哉, 武冨 紹信, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - VSY-12-2 適応拡大を目指した腹腔鏡下肝切除における肝門部処理・肝実質切離法の確立(VSY ビデオシンポジウム,第113回日本外科学会定期学術集会)
神山 俊哉, 横尾 英樹, 柿坂 達彦, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - VSY-15-6 3D画像支援システムによる下右肝静脈還流領域を評価した肝切除(VSY ビデオシンポジウム,第113回日本外科学会定期学術集会)
横尾 英樹, 神山 俊哉, 柿坂 達彦, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - PS-088-1 肝細胞癌における予後再発因子としてのFABP5発現の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)
大畑 多嘉宣, 横尾 英樹, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 神山 俊哉, 武富 紹信, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - PS-093-3 肝細胞癌における血中遊離癌細胞と骨髄癌細胞の同定の試み(PS ポスターセッション,第113回日本外科学会定期学術集会)
皆川 のぞみ, 崎浜 秀康, 小林 希, 若山 顕治, 柿坂 達彦, 敦賀 陽介, 下國 達志, 本間 重紀, 横尾 秀樹, 蒲池 浩文, 高橋 典彦, 神山 俊哉, 武冨 紹信, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - PS-229-6 膵癌門脈合併切除術後門脈狭窄に対するステント留置の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)
敦賀 陽介, 蒲池 浩文, 若山 顕治, 柿坂 達彦, 横尾 英樹, 神山 俊哉, 武冨 紹信, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - PS-352-1 vp3,4肝細胞癌の門脈腫瘍栓に対する術前放射線治療の有効性の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)
柿坂 達彦, 神山 俊哉, 横尾 英樹, 若山 顕治, 敦賀 陽介, 蒲池 浩文, 武冨 紹信, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - PS-352-2 肝細胞癌下大静脈/右心房腫瘍栓に対する外科的治療(PS ポスターセッション,第113回日本外科学会定期学術集会)
若山 顕治, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 蒲池 浩文, 敦賀 陽介, 山下 健一郎, 鈴木 知己, 嶋村 剛, 藤堂 省, 武冨 紹信, 日本外科学会雑誌, 114, 2, 05 Mar. 2013
一般社団法人日本外科学会, Japanese - 腹腔鏡補助下で切除した大腸癌同時性多発性肝転移の一例
蔵谷勇樹, 皆川のぞみ, 若山顕治, 敦賀陽介, 柿坂達彦, 下國達志, 崎浜秀康, 本間重紀, 横尾秀樹, 蒲池浩文, 高橋典彦, 神山俊哉, 武富紹信, 日本臨床外科学会雑誌, 74, 2, 591, 591, 25 Feb. 2013
日本臨床外科学会, Japanese - 肝細胞癌における予後再発因子としてのFABP5の有用性について
大畑多嘉宣, 横尾英樹, 柿坂達彦, 若山顕治, 敦賀陽介, 蒲池浩文, 神山俊哉, 武冨紹信, 日本消化器癌発生学会総会プログラム・抄録集, 24th, 97, 2013
Japanese - 当科における門脈再建法
敦賀陽介, 蒲池浩文, 若山顕治, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 25th, 279, 279, 2013
(一社)日本肝胆膵外科学会, Japanese - 肝門側からの展開困難な血管合併切除を要する左葉系肝門部胆管癌に対する術式の工夫
蒲池浩文, 敦賀陽介, 若山顕治, 柿坂達彦, 横尾英樹, 神山俊哉, 武冨紹信, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 25th, 253, 253, 2013
(一社)日本肝胆膵外科学会, Japanese - 下大静脈/右心房腫瘍栓を有する肝細胞癌に対する肝切除
若山顕治, 神山俊哉, 横尾英樹, 柿坂達彦, 蒲池浩文, 敦賀陽介, 中西一彰, 嶋村剛, 藤堂省, 武冨紹信, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 25th, 278, 278, 2013
(一社)日本肝胆膵外科学会, Japanese - 大腸癌多発肝転移に対する外科切除のタイミング
横尾英樹, 神山俊哉, 柿坂達彦, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 25th, 235, 235, 2013
(一社)日本肝胆膵外科学会, Japanese - 肝細胞癌リンパ節転移症例に対する治療法の検討
柿坂達彦, 神山俊哉, 横尾英樹, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本肝胆膵外科学会・学術集会プログラム・抄録集, 25th, 411, 411, 2013
(一社)日本肝胆膵外科学会, Japanese - 肝細胞癌における循環腫瘍細胞ならびに骨髄腫瘍細胞と臨床病理組織学的因子の検討
皆川のぞみ, 崎浜秀康, 小林希, 小原美都, 柴崎晋, 若山顕治, 柿坂達彦, 敦賀陽介, 本間重紀, 横尾秀樹, 蒲池浩文, 川村秀樹, 高橋典彦, 神山俊哉, 武冨紹信, 日本消化器癌発生学会総会プログラム・抄録集, 24th, 98, 2013
Japanese - 肝尾状葉腫瘍切除における3次元画像解析システムの有用性
若山顕治, 敦賀陽介, 柿坂達彦, 横尾英樹, 蒲池浩文, 神山俊哉, 武冨紹信, 北海道外科雑誌, 57, 2, 189, 190, 20 Dec. 2012
北海道外科学会, Japanese - 右葉系腹腔鏡下肝切除時の肝脱転の工夫
柿坂達彦, 神山俊哉, 横尾英樹, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 北海道外科雑誌, 57, 2, 189, 189, 20 Dec. 2012
北海道外科学会, Japanese - 腹腔鏡補助下で一期的に切除した大腸癌同時性多発性肝転移の2例
皆川 のぞみ, 本間 重紀, 下國 達志, 崎浜 秀康, 若山 顕治, 敦賀 陽介, 柿坂 達彦, 横尾 秀樹, 蒲池 浩文, 高橋 典彦, 神山 俊哉, 武富 紹信, 日本内視鏡外科学会雑誌, 17, 7, 725, 725, Dec. 2012
(一社)日本内視鏡外科学会, Japanese - ハーモニックスカルペルとVIO systemのsoft凝固モードを用いたDS 3.0による肝切離
横尾英樹, 神山俊哉, 柿坂達彦, 敦賀陽介, 若山顕治, 蒲池浩文, 武冨紹信, 日本臨床外科学会雑誌, 73, 増刊, 564, 564, 20 Oct. 2012
日本臨床外科学会, Japanese - 巨大肝細胞癌手術症例の臨床病理学的検討
柿坂達彦, 神山俊哉, 横尾英樹, 若山顕治, 敦賀陽介, 蒲池浩文, 武冨紹信, 日本臨床外科学会雑誌, 73, 増刊, 686, 686, 20 Oct. 2012
日本臨床外科学会, Japanese - 肝細胞癌における骨髄転移性腫瘍の同定(Cellular detection of disseminated tumor cells in bone marrow of patients with hepatocellular carcinoma)
崎浜 秀康, 小林 希, 皆川 のぞみ, 柿坂 達彦, 敦賀 陽介, 下國 達志, 本間 重紀, 横尾 英樹, 蒲池 浩文, 中西 一彰, 高橋 典彦, 神山 俊哉, 武冨 紹信, 日本癌学会総会記事, 71回, 69, 69, Aug. 2012
日本癌学会, English - SF-038-6 Transparenchymal glissonean approachを用いた肝左葉系切除を要する肝門部胆管系腫瘍切除限界(SF-038 サージカルフォーラム(38)胆 悪性-3(胆門部胆管癌),第112回日本外科学会定期学術集会)
蒲池 浩文, 敦賀 陽介, 柿坂 達彦, 横尾 英樹, 中西 一彰, 山下 健一郎, 松下 通明, 神山 俊哉, 日本外科学会雑誌, 113, 2, 336, 336, 05 Mar. 2012
一般社団法人日本外科学会, Japanese - SF-069-4 R0をめざした局所進行肝内胆管癌の外科治療戦略(SF-069 サージカルフォーラム(69)肝 悪性-2,第112回日本外科学会定期学術集会)
横尾 英樹, 中西 一彰, 柿坂 達彦, 敦賀 陽介, 薄地 浩文, 松下 通明, 神山 俊哉, 日本外科学会雑誌, 113, 2, 378, 378, 05 Mar. 2012
一般社団法人日本外科学会, Japanese - PS-029-6 門脈侵襲陽性肝細胞癌に対する治療戦略(PS-029 肝 肝細胞癌-1,第112回日本外科学会定期学術集会)
中西 一彰, 横尾 英樹, 柿坂 達彦, 敦賀 陽介, 蒲池 浩文, 松下 通明, 神山 俊哉, 日本外科学会雑誌, 113, 2, 551, 551, 05 Mar. 2012
一般社団法人日本外科学会, Japanese - PS-037-1 局所進行膵癌に対する術前放射線化学療法の効果(PS-037 膵 周学的治療-1,第112回日本外科学会定期学術集会)
敦賀 陽介, 蒲池 浩文, 柿坂 達彦, 横尾 英樹, 中西 一彰, 松下 通明, 神山 俊哉, 日本外科学会雑誌, 113, 2, 565, 565, 05 Mar. 2012
一般社団法人日本外科学会, Japanese - PS-091-2 肝細胞癌に対する無水エタノールを用いた術前門脈塞栓術の検討(PS-091 門脈,ポスターセッション,第112回日本外科学会定期学術集会)
柿坂 達彦, 横尾 英樹, 中西 一彰, 敦賀 陽介, 蒲池 浩文, 神山 俊哉, 日本外科学会雑誌, 113, 2, 673, 673, 05 Mar. 2012
一般社団法人日本外科学会, Japanese - SY-3-7 再発肝細胞癌への治療戦略Salvage肝移植を考慮して(SY-3 シンポジウム(3)再発肝細胞癌に対する治療戦略,第111回日本外科学会定期学術集会)
神山 俊哉, 中西 一彰, 横尾 英樹, 蒲池 浩文, 田原 宗徳, 柿坂 達彦, 小丹枝 裕二, 山下 健一郎, 谷口 雅彦, 鈴木 知己, 嶋村 剛, 古川 博之, 松下 通明, 藤堂 省, 日本外科学会雑誌, 112, 1, 235, 235, 25 May 2011
一般社団法人日本外科学会, Japanese - VS-2-11 肝門部胆管系腫瘍切除における血管合併切除の手技 : Transparenchymal glissonean approachの応用(VS-2 ビデオシンポジウム(2)血管再建を伴う肝切除の手技上の工夫とその意義,第111回日本外科学会定期学術集会)
蒲池 浩文, 神山 俊哉, 田原 宗徳, 柿坂 達彦, 谷口 雅彦, 山下 健一郎, 横尾 英樹, 中西 一彰, 松下 通明, 藤堂 省, 日本外科学会雑誌, 112, 1, 252, 252, 25 May 2011
一般社団法人日本外科学会, Japanese - PS-131-2 混合型肝癌10例の臨床病理学的検討(PS-131 ポスターセッション(131)肝臓:基礎-6,第111回日本外科学会定期学術集会)
柿坂 達彦, 神山 俊哉, 中西 一彰, 横尾 英樹, 蒲地 浩文, 田原 宗徳, 谷口 雅彦, 松下 通明, 藤堂 省, 日本外科学会雑誌, 112, 1, 731, 731, 25 May 2011
一般社団法人日本外科学会, Japanese - PS-197-6 同時性肝転移を有する大腸癌に対する治療方針(PS-197 ポスターセッション(197)大腸:手術-6,第111回日本外科学会定期学術集会)
下國 達志, 柿坂 達彦, 本間 重紀, 田原 宗徳, 崎浜 秀康, 横尾 英樹, 谷口 雅彦, 蒲池 浩文, 中西 一彰, 高橋 典彦, 片岡 昭彦, 神山 俊哉, 松下 通明, 藤堂 省, 日本外科学会雑誌, 112, 1, 848, 848, 25 May 2011
一般社団法人日本外科学会, Japanese - PS-204-4 初心者においても安全な肝実質切離法 : フックブレード型のハーモニックスカルペルとsoft凝固モードを用いたTissuelink dissecting sealerによる肝切離(PS-204 ポスターセッション(204)肝臓:手術-7,第111回日本外科学会定期学術集会)
中西 一彰, 神山 俊哉, 横尾 英樹, 柿坂 達彦, 田原 宗徳, 蒲池 浩文, 谷口 雅彦, 松下 通明, 藤堂 省, 日本外科学会雑誌, 112, 1, 860, 860, 25 May 2011
一般社団法人日本外科学会, Japanese - PS-209-4 局所進展膵癌に対する術前化学放射線療法後の画像評価 : 動脈周囲神経叢浸潤に着目して(PS-209 ポスターセッション(209)膵臓:悪性・診断-1,第111回日本外科学会定期学術集会)
田原 宗徳, 蒲池 浩文, 柿坂 達彦, 横尾 英樹, 中西 一彰, 神山 俊哉, 松下 通明, 藤堂 省, 日本外科学会雑誌, 112, 1, 868, 868, 25 May 2011
一般社団法人日本外科学会, Japanese - AFP産生胃癌肝転移に対して外科的切除を施行した4例
旭火華, 神山俊哉, 横尾英樹, 本間重紀, 中西一彰, 柿坂達彦, 下國達志, 田原宗徳, 崎浜秀康, 蒲池浩文, 高橋典彦, 片岡昭彦, 松下通明, 藤堂省, 日本臨床外科学会雑誌, 72, 4, 1066, 1066, 25 Apr. 2011
日本臨床外科学会, Japanese - P-1-643 肝膿瘍を契機に発見された大腸癌の2例(大腸悪性6,一般演題(ポスター),第63回日本消化器外科学会総会)
片山 知也, 柿坂 達彦, 菊地 健, 植村 一仁, 米山 重人, 伊藤 美夫, 宇根 良衛, 日本消化器外科学会雑誌, 41, 7, 1417, 1417, 01 Jul. 2008
一般社団法人日本消化器外科学会, Japanese - Plasma proteomics of pancreatic cancer patients by multidimensional liquid chromatography and two-dimensional difference gel electrophoresis
Tatsuhiko Kakisaka, Tadashi Kondo, Tetsuya Okano, Kiyonaga Fujii, Kazufumi Honda, Mitsufumi Endo, Akihiko Tsuchida, Tatsuya Aoki, Takao Itoi, Fuminori Moriyasu, Tesshi Yamada, Harubumi Kato, Toshihide Nishimura, Satoru Todo, Setsuo Hirohashi, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 22, A249, A249, Oct. 2007
English, Summary international conference - Toward comprehensive expression proteomics in cancer research
T. Kondo, K. Fujii, H. Kuribayashi, T. Orimo, K. Ashizawa, M. Yamada, Y. Suehara, H. Hatakeyama, T. Kakisaka, T. Okano, S. Hirohashi, MOLECULAR & CELLULAR PROTEOMICS, 5, 10, S155, S155, Oct. 2006
English, Summary international conference - 1.外傷を契機に急性腹症で発症した腹壁原発横紋筋肉腫の1例(第29回北海道小児がん研究会,研究会)
岡田 忠雄, 佐々木 文章, 鈴木 陽三, 柿坂 達彦, 藤堂 省, 佐藤 智信, 中嶋 雅秀, 井口 晶裕, 小林 良二, 小林 邦彦, 太田 聡, 伊藤 智雄, 小児がん : 小児悪性腫瘍研究会記録, 41, 2, 302, 303, 05 Oct. 2004
特定非営利活動法人日本小児血液・がん学会, Japanese - Serum proteomics of lung cancer by multi-dimensional liquid chromatography and gel electrophoresis
Tetsuya Okano, Tadashi Kondo, Tatsuhiko Kakisaka, Tesshi Yamada, Setsuo Hirohashi, MOLECULAR & CELLULAR PROTEOMICS, 3, 10, S225, S225, Oct. 2004
English, Summary international conference - 1.乳び胸水を呈した新生児横隔膜ヘルニアの1例(第70回日本小児外科学会北海道地方会)
鈴木 陽三, 柿坂 達彦, 井上 謙一, 常俊 雄介, 藤堂 省, 佐々木 文章, 岡田 忠雄, 長 和俊, 岡嶋 覚, 日本小児外科学会雑誌, 40, 5, 737, 737, 20 Aug. 2004
特定非営利活動法人日本小児外科学会, Japanese - 14.便秘を契機に診断されたCurrarino症候群の1例(第70回日本小児外科学会北海道地方会)
常俊 雄介, 井上 謙一, 柿坂 達彦, 鈴木 陽三, 藤堂 省, 佐々木 文章, 岡田 忠雄, 伊藤 智雄, 太田 聡, 日本小児外科学会雑誌, 40, 5, 740, 740, 20 Aug. 2004
特定非営利活動法人日本小児外科学会, Japanese - 71.原発性胃悪性リンパ腫21例の臨床病理学的検討(再建術式とその機能評価(V))(第32回胃外科・術後障害研究会)
野村 克, 尾崎 篤子, 宇野 元博, 柿坂 達彦, 唐崎 秀則, 赤羽 弘充, 安原 満夫, 中野 詩朗, 高橋 昌宏, 日本消化器外科学会雑誌, 36, 9, 1358, 1358, 01 Sep. 2003
一般社団法人日本消化器外科学会, Japanese - 大腸癌術後創感染に対する予防的抗菌剤投与の検討
中野 詩朗, 高橋 昌宏, 宇野 元博, 柿坂 達彦, 唐崎 秀則, 野村 克, 安原 満夫, 赤羽 弘允, 日本消化器外科学会雑誌, 36, 7, 1107, 1107, 01 Jul. 2003
一般社団法人日本消化器外科学会, Japanese - 中下部胆管癌切除例の予後因子の検討
唐崎 秀則, 高橋 昌宏, 中野 詩朗, 赤羽 弘光, 安原 満夫, 青木 貴徳, 野村 克, 柿坂 達彦, 宇野 元博, 尾崎 篤子, 日本消化器外科学会雑誌, 36, 7, 898, 898, 01 Jul. 2003
一般社団法人日本消化器外科学会, Japanese - PC-1-036 腹部大動脈周囲リンパ節転移の郭清と術後化学療法により無再発生存中の胃癌の1例
小笠原 和宏, 高橋 学, 小川 秀彰, 井本 秀幸, 菊地 一公, 柿坂 達彦, 山本 貢, 真鍋 邦彦, 内野 純一, 日本消化器外科学会雑誌, 35, 7, 1244, 1244, 01 Jul. 2002
一般社団法人日本消化器外科学会, Japanese - 原発性食道癌に対する術前化学放射線療法の検討
井本 秀幸, 柿坂 達彦, 山本 貢, 菊地 一公, 小川 秀彰, 高橋 学, 小笠原 和宏, 真鍋 邦彦, 内野 純一, 日本外科学会雑誌, 103, 569, 569, 10 Mar. 2002
一般社団法人日本外科学会, Japanese - 胃癌全摘における10番リンパ節転移症例の検討
菊地 一公, 小笠原 和宏, 山本 貢, 柿坂 達彦, 井本 秀幸, 小川 秀影, 高橋 学, 真鍋 邦彦, 内野 純一, 日本外科学会雑誌, 103, 572, 572, 10 Mar. 2002
一般社団法人日本外科学会, Japanese - 組織学的stage・直腸癌におけるss/a1症例とse/a2症例の再発率及び生存率の比較
小川 秀彰, 小笠原 和宏, 高橋 学, 井本 秀幸, 菊地 一公, 柿坂 達彦, 山本 貢, 真鍋 邦彦, 内野 純一, 日本外科学会雑誌, 103, 513, 513, 10 Mar. 2002
一般社団法人日本外科学会, Japanese - アフェレシス療法の対象となる生体肝移植後高ビリルビン血症とグラフト容積との関係 : 日本アフェレシス学会第19回北海道地方会
柿坂 達彦, 松下 通明, 大村 孝志, 岸田 明博, 古川 博之, 藤堂 省, 日本アフェレシス学会雑誌, 19, 1, 59, 60, 29 Feb. 2000
日本アフェレシス学会, Japanese - 十二指腸上行結腸瘻を合併した Crohn 病の1切除例
柿坂達彦, 日臨外会誌, 61, 1093, 1093, 2000
Research Themes
- 消化器がんに対するDGKα/ζを標的とした核酸医薬による新規免疫療法の開発研究
科学研究費助成事業 基盤研究(B)
01 Apr. 2022 - 31 Mar. 2025
武冨 紹信, 北村 秀光, 柿坂 達彦, 深井 原
日本学術振興会, 基盤研究(B), 北海道大学, 22H03142 - 血中exosome内circRNA発現解析による膵癌の診断・予後関連マーカー探索
科学研究費助成事業 基盤研究(C)
01 Apr. 2022 - 31 Mar. 2025
柿坂 達彦, 蒲池 浩文, 長田 直樹, 神山 俊哉, 折茂 達也
日本学術振興会, 基盤研究(C), 北海道大学, 22K08789 - Comprehensive glycan analysis based on resected specimens of hepatocellular carcinoma
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
01 Apr. 2021 - 31 Mar. 2024
神山 俊哉, 西村 紳一郎, 旭 火華, 坂本 譲, 柿坂 達彦, 折茂 達也, 長津 明久
これまでの糖鎖解析を行う癌に関する研究は、患者血清を用いるものが多かったが、患者背景：併存する疾患、人種などの影響があり、癌細胞上で行われる糖鎖修飾がどのように癌細胞の生物学的な悪性度を関連性があるかは未解決である。肝癌細胞株での実験で、これまで報告された患者血清から検出された糖鎖と異なるものが、浸潤能に関与していることが分かったため、実際の切除検体である癌細胞組織での検討が必要であるとの考えに至った。
今年度は、実際の切除検体である癌細胞組織での糖鎖解析による検討を行った。2001年から2006年までの肝細胞癌切除例48例の凍結検体の網羅的糖鎖解析による糖鎖発現を全自動血清糖鎖プロファイル解析で行った。1325.55m/zから3336.24m/zまでの39個の糖鎖を検出でき、肝癌組織のN型糖鎖プロファイルを解析できた。凍結保存された肝細胞癌切除標本の糖鎖解析が普遍的に可能であることが検証された。今後、同一患者さんで、非癌部の肝組織、血清での発現と、今回検出できた糖鎖との関連性を検証していく。さらにこれらの結果と臨床病理学的所見・組織病理学的所見、切除後の予後・再発との関連性を検討する予定であり、実際の肝細胞癌組織と癌悪性度、浸潤能などとの関連性がある特異の糖鎖が発見され、この糖鎖修飾を阻害することができる阻害剤が見つかれば、創薬の点からも癌治療に大きく貢献できると確信している。肝切除かあるいは分子標的薬による薬物治療かの治療選択基準となりうる新規バイオマーカーを検出できる可能性がある。
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 21K07210 - Protein expression analysis of leucine-rich alpha-2-glycoprotein in serum as a new diagnostic marker of pancreatic cancer focusing on the posttranslational modification
Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
01 Apr. 2014 - 31 Mar. 2018
Kakisaka Tatsuhiko
The prognosis of pancreatic cancer (PC) is extremely poor and it is difficult to diagnose PC in early stage. We analyzed leucine-rich alpha-2-glycoprotein (LRG) in serum as a new diagnostic marker of PC. We used the serum of PC patients (n=68) and healthy volunteer (n=10) and analyzed the serum concentration of LRG by ELISA. We found that LRG levels of PC patients in all stages were significantly up-regulated compared with those of healthy volunteers. Moreover, LRG concentrations were highly expressed in 22 of 25 PC patients whose serum levels of CA19-9 were low. LRG is a candidate of new diagnostic marker of PC. We plan to isolate LRG from serum and analyze differentially expressed glycans of LRG in future research.
Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, 26870002 - The molecular mechanism of adenomatous polyposis coli-binding protein EB1 in HCC
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
01 Apr. 2013 - 31 Mar. 2016
NAKANISHI Kazuaki, YOKOO Hideki, KAKISAKA Tatsuhiko, KAMIYAMA Toshiya, TAKETOMI Akinobu, ORIMO Tatsuya, FUKUHARA Takasuke, OHATA Takanori, TAKAHASHI Hidenori, KOBAYASHI Nozomi, MIYOSHI Sayaka, HORIGOME Masatoshi
We previously reported that adenomatous polyposis coli-binding protein EB1 (EB1) is overexpressed in HCC tissues by proteomics. In present study, ①EB1 expression significantly correlated with the degree of histological differentiation, AFP, vascular invasion status in HCC patients. Moreover, overall survival and recurrence rate was significantly poor in EB1-high expressed HCC patients. ②EB1 promoted cell proliferation, migration, invasion, tumor growth in HCC cell lines. ③Microarray analysis revealed that EB1 might regulate the expression level of Dlk-1. As a conclusion, EB1 may become a new biomarker of HCC and a potential molecular target of HCC therapy.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 25430134 - Clinical significance of Fatty Acid Binding Protein 5 in hepatocellular carcinoma
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
2011 - 2013
YOKOO Hideki, KAMIYAMA Toshiya, NAKANISHI Kazuaki, KAKISAKA Tatsuhiko
We analyzed the correlation between the expression of FABP5 and malignant behavior of HCC using HCC tissues and cell lines. A total of 243 HCC samples were subjected to immunohistochemistry, and protein expression of FABP5 in HCC cell lines was assessed by Western blot. The intensity of immunostaining in HCC tissues were divided into a strong staining group and a weak staining group. In the strong group, 5-year overall survival rate was 59.5%, compared with 89.9% in the weak group , and 5-year relapse free survival rate in the strong group was 23.7%, compared with 47.2% in the weak group . In vitro, Western blot showed protein expression of highly invasive cell lines was high, while lowly invasive cell was low. The knockdown of FABP5 in highly invasive cell lines also inhibited cell proliferation, migration and invasiveness significantly. FABP5 was closely related with malignancy, and also behaved as a significant prognostic and recurrence factor for HCC patients.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 23501293
