Clinical outcomes of initial inside stenting for preoperative malignant hilar biliary obstruction in patients with jaundice
Ryo Sugiura, Masaki Kuwatani, Kazumichi Kawakubo, Hiroki Yonemura, Shunichiro Nozawa, Shoya Shiratori, Soichiro Oda, Kimitaka Tanaka, Satoshi Hirano, Naoya Sakamoto
Surgery Today, Springer Science and Business Media LLC, 14 May 2025, [Peer-reviewed], [Lead author], [International Magazine]
Scientific journal

Panniculitis of the Lower Extremities Caused by Acute Deterioration of Autoimmune Pancreatitis
Soichiro Oda, Masaki Kuwatani, Shoya Shiratori, Hiroki Yonemura, Syunichiro Nozawa, Ryo Sugiura, Kazumichi Kawakubo, Kazuki Watanabe, Mika Watanabe, Naoya Sakamoto
Journal of Gastroenterology and Hepatology, 40, 5, 1042, 1044, Wiley, 09 May 2025, [Peer-reviewed], [International Magazine]
Scientific journal, ABSTRACT

A 73‐year‐old female with type 1 autoimmune pancreatitis (AIP) presented with painful erythema on her lower extremities and elevated serum pancreatic enzyme levels. Her CT images revealed focal enlargement of the pancreatic tail with an increased density of the surrounding fatty tissue. Based on serum and CT findings, she was diagnosed as having acute deterioration of AIP. Skin biopsy of erythema revealed fat necrosis with ghost cells, calcification, and inflammatory infiltration, consistent with pancreatic panniculitis. Increasing the prednisolone dose to 25 mg/day promptly ameliorated her symptoms and normalized her enzyme levels.

Pancreatic panniculitis is a rare complication of pancreatitis characterized by painful subcutaneous nodules and fat necrosis. Although it has been reported in association with conditions such as pancreatic cancer and chronic pancreatitis, its occurrence in AIP has not been documented. This case highlights pancreatic panniculitis as a potential complication of AIP for the first time.

Rare Pancreatic Neuroendocrine Tumor With Hyalinization Exhibiting Atypical Imaging Features: A Case Report
Shoya Shiratori, Ryo Sugiura, Masaki Kuwatani, Soichiro Oda, Shunichiro Nozawa, Hiroki Yonemura, Kazuma Kishi, Kazumichi Kawakubo, Aya Matsui, Satoshi Hirano, Satoko Yorinaga, Tomoko Mitsuhashi, Naoya Sakamoto
Pancreas, 54, 5, e499, e501, Ovid Technologies (Wolters Kluwer Health), May 2025, [Peer-reviewed], [Corresponding author], [International Magazine]
Scientific journal

A retrospective comparative study of percutaneous transhepatic gallbladder drainage versus endoscopic gallbladder stenting on the clinical course of acute cholecystitis: A propensity score matching analysis using a nationwide inpatient database in Japan
Shota Ebinuma, Hiroyuki Nagano, Hisashi Itoshima, Susumu Kunisawa, Kiyohide Fushimi, Ryo Sugiura, Tatsuhiko Kakisaka, Akinobu Taketomi, Yuichi Imanaka
Journal of Hepato-Biliary-Pancreatic Sciences, 32, 3, 203, 211, Wiley, 15 Jan. 2025, [Peer-reviewed], [International Magazine]
Scientific journal, Abstract

Background

We performed a retrospective comparative study to clarify the optimal gallbladder drainage method prior to elective cholecystectomy.

Methods

We collected data from the Diagnosis Procedure Combination database about cholecystitis patients who underwent gallbladder drainage prior to cholecystectomy in a subsequent hospitalization between April 2014 and March 2020. We divided the study population into two groups: an endoscopic gallbladder stenting (EGBS) group and a percutaneous transhepatic gallbladder drainage (PTGBD) group. We performed propensity score matching and compared surgical outcomes related to cholecystectomy.

Results

We collected 6306 cases (PTGBD: 6112 cases; EGBS: 194 cases). In propensity score matching, we obtained 193 matched pairs from the study population. Long‐term postoperative antibiotics therapy (2 vs. 9; risk ratio 4.7 [95% CI: 1.1–30.9]) was more frequent in the EGBS group than the PTGBD group. There were no significant differences between the two groups for laparotomic cholecystectomy and postoperative bile duct drainage. For reoperation, postoperative abdominal drainage and postoperative blood transfusion, there were few outcome occurrences and effect measures were not obtained.

Conclusion

Gallbladder drainage by EGBS may have more risk of surgical complications related to elective cholecystectomy than PTGBD. There are a few reports on this topic, so further research should be conducted.

Subcutaneous adipose tissue radiodensity as a predictor of poor prognosis in advanced biliary tract cancer
Ryo Sugiura, Yasuyuki Kawamoto, Masaki Kuwatani, Kazumichi Kawakubo, Kazuaki Harada, Masatsugu Ohara, Hiroki Yonemura, Shunichiro Nozawa, Naoya Sakamoto
Journal of Hepato-Biliary-Pancreatic Sciences, 32, 3, 194, 202, Wiley, 08 Jan. 2025, [Peer-reviewed], [Lead author], ［Internationally co-authored］, [International Magazine]
Scientific journal, Abstract

Background

High subcutaneous adipose tissue radiodensity (SATr), an indirect surrogate marker of adipose tissue quality, was associated with poor prognosis in various cancers. The present study aimed to assess the association of SATr with survival outcomes in patients with advanced biliary tract cancer (BTC).

Methods

This retrospective, single‐center study included patients with unresectable or recurrent BTC who underwent chemotherapy/chemoradiotherapy. Overall survival (OS) and progression‐free survival (PFS) were assessed using the log‐rank test and the Cox proportional hazards model according to the SATr status.

Results

The study cohort included 234 patients, including 38 and 196 patients with high and non‐high SATr, respectively. The median OS durations were 10.5 and 17.4 months (HR = 1.72, 95% CI: 1.19–2.49, p < .01) and the median PFS durations were 4.9 and 8.0 months (HR = 1.52, 95% CI: 1.05–2.20, p = .03) in patients with high and non‐high SATr, respectively. By multivariate analysis, high SATr, neutrophil/lymphocyte ratio >5, modified Glasgow prognostic score 1–2, and serum carcinoembryonic antigen >5.0 ng/mL were predictors for OS (HR, 1.66, 2.42, 2.00, and 1.56, respectively; p < .05). By multivariate analysis, metastatic disease status, high SATr, neutrophil/lymphocyte ratio >5, and modified Glasgow prognostic score 1–2 were independent risk factors for worse PFS (HR, 1.56, 1.56, 1.81, and 1.57, respectively; p < .05).

Conclusions

High SATr was associated with risk of tumor progression and poor prognosis in patients with advanced BTC treated by palliative chemotherapy/chemoradiotherapy.

悪性肝門部胆道閉塞に対する初期ドレナージとしての内視鏡的胆道内ステント留置術と内視鏡的経鼻胆道ドレナージ術の比較(Comparison of endoscopic biliary inside stenting with endoscopic nasobiliary drainage as the initial drainage for malignant hilar biliary obstruction)　　　　　　　　　　　　　　　
杉浦 諒, 桑谷 将城, 坂本 直哉
胆道, 38, 3, 383, 383, (一社)日本胆道学会, Sep. 2024
English

胆道癌患者における術前骨格筋量減少の危険因子解析　　　　　　　　　　　　　　　
杉浦 諒, 桑谷 将城, 坂本 直哉, 小田 総一郎, 白鳥 翔也, 野澤 俊一郎, 米村 洋輝, 川久保 和道
胆道, 38, 3, 461, 461, (一社)日本胆道学会, Sep. 2024
Japanese

Preoperative risk factors for skeletal muscle mass loss in patients with biliary tract cancer
Ryo Sugiura, Masaki Kuwatani, Kazumichi Kawakubo, Kazuma Kishi, Hiroki Yonemura, Shunichiro Nozawa, Masatsugu Ohara, Takehiro Noji, Satoshi Hirano, Naoya Sakamoto
Journal of Hepato-Biliary-Pancreatic Sciences, 31, 8, 549, 558, Wiley, Aug. 2024, [Peer-reviewed], [Lead author], ［Internationally co-authored］, [International Magazine]
Scientific journal, Abstract

Background

Endoscopic retrograde cholangiography (ERC)‐related procedures, usually performed before biliary tract cancer (BTC) surgery, are associated with increased risk for various complications, which can cause sarcopenia. No study has previously elucidated the relationship between preoperative ERC‐related procedures and sarcopenia/skeletal muscle mass loss.

Methods

Patients with BTC who underwent radical surgical resection following ERC‐related procedures were included. Skeletal muscle mass was evaluated using the psoas muscle mass index (PMI), which was determined using computed tomography images, and the change in PMI before the initial pre‐ERC and surgery (ΔPMI) was calculated. Risk factors for advanced skeletal muscle mass loss, defined as a large ΔPMI, were evaluated.

Results

The study cohort included 90 patients with a median age of 72 (interquartile range, 65–75) years. The median PMI pre‐ERC and surgery was 4.40 and 4.15 cm²/m², respectively (p < .01). The median ΔPMI was −6.2% (interquartile range, −10.9% to 0.5%). By multivariate analysis, post‐ERC pancreatitis and cholangitis before surgery were independent predictive factors for large PMI loss (odds ratio, 4.57 and 3.18, respectively; p = .03 and p = .02, respectively).

Conclusions

Skeletal muscle mass decreases preoperatively in most patients with BTC undergoing ERC. Post‐ERC pancreatitis and cholangitis before surgery were independent risk factors for large skeletal muscle mass loss.

膵IPMN長期経過観察例の評価 IPMN患者における骨格筋量減少の膵発癌に与える影響
小田 総一郎, 川久保 和道, 白鳥 翔也, 野澤 俊一郎, 米村 洋輝, 岸 法磨, 杉浦 諒, 桑谷 将城, 坂本 直哉
膵臓, 39, 3, A308, A308, (一社)日本膵臓学会, Jul. 2024
Japanese

Risk factors for recurrent biliary obstruction following endoscopic biliary stenting in patients with unresectable ampullary cancer: A multicenter retrospective study
Ryo Sugiura, Masaki Kuwatani, Toshifumi Kin, Ryusuke Matsumoto, Yuki Ikeda, Itsuki Sano, Koji Hirata, Makoto Yoshida, Yoshiharu Masaki, Michihiro Ono, Hajime Hirata, Hiroaki Yamato, Manabu Onodera, Hideaki Nakamura, Yoko Taya, Nobuyuki Ehira, Masahito Nakajima, Hidemasa Kawabata, Hideyuki Ihara, Taiki Kudo, Shin Kato, Akio Katanuma
Journal of Digestive Diseases, 25, 5, 310, 317, Wiley, 20 Jun. 2024, [Peer-reviewed], [Lead author], [International Magazine]
Scientific journal, Objectives

Unresectable ampullary cancer (AC) is a rare disease entity. The risk factors for recurrent biliary obstruction (RBO) following endoscopic biliary stenting (EBS) for unresectable AC remain unknown. In this study we aimed to evaluate the cumulative RBO rate and to identify risk factors for RBO following palliative EBS in patients with unresectable AC.

Methods

This multicenter retrospective observational study enrolled consecutive patients with unresectable AC who had undergone palliative EBS between April 2011 and December 2021. The cumulative rate of and risk factors for RBO following palliative EBS were evaluated via multivariate analysis.

Results

The study analysis comprised 107 patients with a median age of 84 years (interquartile range 79–88 years). Plastic stents (PSs) and self‐expandable metal stents (SEMSs) were placed in 53 and 54 patients, respectively. Functional success was accomplished in 104 (97.2%) patients. Of these, RBO occurred in 62 (59.6%) patients, with obstruction and complete/partial migration occurring in 47 and 15 patients, respectively. The median time to RBO was 190 days. Multivariate analysis showed that PS was associated with a higher rate of RBO compared to SEMS (hazard ratio [HR] 2.48; P < 0.01) and that the presence of common bile duct stones/sludge immediately after EBS was an independent risk factor for RBO (HR 1.99; P = 0.04).

Conclusions

The use of SEMS compared to PS during EBS reduced the time to RBO in patients with unresectable AC. Common bile duct stones/sludge immediately after EBS was a risk factor for RBO.

膵管狭窄/拡張に対する内視鏡的逆行性膵管造影下ブラシ細胞診と連続膵液細胞診の診断能の比較　　　　　　　　　　　　　　　
杉浦 諒, 桑谷 将城, 坂本 直哉
Gastroenterological Endoscopy, 66, Suppl.1, 1016, 1016, (一社)日本消化器内視鏡学会, Apr. 2024
Japanese

膵癌早期診断の試み 十二指腸液中のメタボローム解析による膵良悪性疾患の鑑別
岸 法磨, 桑谷 将城, 小田 総一郎, 白鳥 翔也, 米村 洋輝, 野澤 俊一郎, 杉浦 諒, 川久保 和道, 坂本 直哉
日本消化器病学会雑誌, 121, 臨増総会, A221, A221, (一財)日本消化器病学会, Mar. 2024
Japanese

【胆膵の画像・内視鏡診断の進歩-早期診断と正確な診断のために】閉塞性黄疸に対する内視鏡的診断アプローチ EUS/ERCP
桑谷 将城, 米村 洋輝, 野澤 俊一郎, 岸 法磨, 杉浦 諒, 川久保 和道, 坂本 直哉
臨床消化器内科, 38, 13, 1625, 1631, (株)日本メディカルセンター, Nov. 2023
Japanese

非切除十二指腸乳頭部癌症例における胆管ステント機能不全の危険因子解析 多施設共同後方視的観察研究　　　　　　　　　　　　　　　
杉浦 諒, 桑谷 将城, 金 俊文, 松本 隆祐, 池田 裕貴, 佐野 逸紀, 平田 幸司, 吉田 真誠, 柾木 喜晴, 小野 道洋, 平田 甫, 大和 弘明, 小野寺 学, 中村 英明, 多谷 容子, 江平 宣起, 中島 正人, 潟沼 朗生, Hokkaido Interventional EUS ERCP study(HONEST) group
Gastroenterological Endoscopy, 65, Suppl.2, 1993, 1993, (一社)日本消化器内視鏡学会, Oct. 2023
Japanese

Metabolomics of Duodenal Juice for Biliary Tract Cancer Diagnosis
Kazuma Kishi, Masaki Kuwatani, Yuki Ohnishi, Yasuhiro Kumaki, Hiroyuki Kumeta, Hajime Hirata, Yunosuke Takishin, Ryutaro Furukawa, Kosuke Nagai, Hiroki Yonemura, Shunichiro Nozawa, Ryo Sugiura, Kazumichi Kawakubo, Tomoyasu Aizawa, Naoya Sakamoto
Cancers, 15, 17, 4370, 4370, MDPI AG, 01 Sep. 2023, [Peer-reviewed], [International Magazine]
Scientific journal, The poor prognosis of malignant biliary diseases is partially caused by their difficult early diagnosis. Therefore, many patients are only diagnosed at advanced stages. This study aimed to improve diagnosis by clarifying the differences in the duodenal juice metabolomes of benign and malignant biliary diseases. From October 2021 to January 2023, duodenal juice was obtained from 67 patients with suspected biliary diseases who required endoscopic ultrasonography and endoscopic retrograde cholangiography for diagnosis/treatment. The samples metabolomes were analyzed via nuclear magnet resonance spectroscopy using an 800-MHz spectrometer. Metabolomes of malignant and benign diseases were then compared, and multivariate analysis was performed to determine the relevant factors for malignancy/benignancy. For benignancy, no significant predictors were observed. For malignancy, acetone was a significant predictor, with higher concentrations in the malignant group than in the benign group. Regarding the receiver operating characteristic curve analysis for biliary tract carcinoma diagnosis, the predictive value of acetone in duodenal juice was comparable with serum CA19-9 levels (area under the curve: 0.7330 vs. 0.691, p = 0.697). In conclusion, duodenal juice metabolomics is a feasible method that is available for differential diagnosis in the biliary disease field.

Significance of Shear Wave Dispersion Slope Values Before Versus After Biliary Drainage in Patients With Obstructive Jaundice
Ryo Sugiura, Masaki Kuwatani, Mutsumi Nishida, Megumi Satoh, Kazumichi Kawakubo, Shin Kato, Koji Hirata, Masahito Nakajima, Hajime Hirata, Yunosuke Takishin, Naoya Sakamoto
Ultrasound Quarterly, 39, 3, 152, 157, Ovid Technologies (Wolters Kluwer Health), Sep. 2023, [Peer-reviewed], [Lead author], [International Magazine]
Scientific journal

Temporary rescue hemostasis for arterial hemorrhage using pentapod forceps during direct endoscopic necrosectomy.
Ryo Sugiura, Kazuma Kishi, Masaki Kuwatani
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 35, 4, 540, 540, May 2023, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal

A rare case of pancreatic acinar cell carcinoma presenting a submucosal tumor
Ryo Sugiura, Hidetoshi Kagaya, Hideaki Nakamura, Shoichi Horita, Takashi Meguro, Kiyotaka Sasaki, Tatsuya Yoshida, Hironori Aoki, Masaki Kuwatani, Masayuki Fukushima, Takayuki Morita, Miyoshi Fujita, Keisuke Okamura, Eiji Tamoto, Takashi Ueno, Akio Tsutaho, Ayano Inoue, Toshiyuki Takahashi
Endoscopic Ultrasound, 12, 2, 300, 300, Medknow, Apr. 2023, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
Scientific journal

A rare case of pancreatic ductal adenocarcinoma with ossification mimicking a pancreatic stone impaction
Ryo Sugiura, Kiyotaka Sasaki, Hideaki Nakamura, Shoichi Horita, Takashi Meguro, Hidetoshi Kagaya, Tatsuya Yoshida, Hironori Aoki, Takayuki Morita, Miyoshi Fujita, Keisuke Okamura, Eiji Tamoto, Masayuki Fukushima, Takashi Ueno, Akio Tsutaho, Ayano Inoue, Toshiyuki Takahashi
Endoscopic Ultrasound, 12, 2, 290, 290, Medknow, Apr. 2023, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
Scientific journal

Hepatocellular Carcinoma Rupture after Introducing Lenvatinib: An Autopsy Case Report.
Risako Kohya, Ryo Sugiura, Yoshiya Yamamoto, Hirohito Naruse, Kazuteru Hatanaka, Kenji Kinoshita, Satoshi Abiko, Shuichi Miyamoto, Kazuharu Suzuki, Hanae Kushibiki, Satoru Munakata, Norihiko Shimoyama
Internal medicine (Tokyo, Japan), 62, 7, 995, 998, Japanese Society of Internal Medicine, 01 Apr. 2023, [Peer-reviewed], [Corresponding author], [Domestic magazines]
English, Scientific journal, Hepatocellular carcinoma (HCC) hemorrhaging/rupture is a rare adverse effect of lenvatinib, and only limited pathological examinations have been reported. This report presents the case of a 69-year-old man who suffered from cardiac arrest and died 7 days after starting lenvatinib treatment for HCC, with an autopsy subsequently performed. Crack and coagulated blood were observed in the largest tumor. Pathologically, the hemorrhaging area was scattered in nearly all of the HCC lesions, regardless of tumor differentiation. This pathological feature is unusual in normal HCC. Thus, it is believed to have been the effect of lenvatinib.

Effects of activation of an alcohol metabolic gene, cigarette smoking, and alcohol intake on the incidence of metachronous gastric cancer in patients who underwent endoscopic resection for gastric cancer: A multicenter retrospective pilot study
Satoshi Abiko, Yuichi Shimizu, Marin Ishikawa, Masaki Inoue, Katsuma Nakajima, Risako Kohya, Koji Hirata, Kazuharu Suzuki, Ryo Sugiura, Shuichi Miyamoto, Kenji Kinoshita, Kazuteru Hatanaka, Yoshiya Yamamoto, Hirohito Naruse, Takuto Miyagishima, Naoya Sakamoto
JGH Open, 7, 4, 305, 310, Wiley, 31 Mar. 2023, [Peer-reviewed], [International Magazine]
Scientific journal

Genetic Analyses of Cell-Free DNA in Pancreatic Juice or Bile for Diagnosing Pancreatic Duct and Biliary Tract Strictures.
Kosuke Nagai, Masaki Kuwatani, Koji Hirata, Goki Suda, Hajime Hirata, Yunosuke Takishin, Ryutaro Furukawa, Kazuma Kishi, Hiroki Yonemura, Shunichiro Nozawa, Ryo Sugiura, Kazumichi Kawakubo, Naoya Sakamoto
Diagnostics (Basel, Switzerland), 12, 11, 2704, 2704, MDPI AG, 05 Nov. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Poor prognosis of pancreaticobiliary malignancies is attributed to intrinsic biological aggressiveness and the lack of reliable methods for early diagnosis. This study aimed to evaluate the feasibility and availability of pancreatic juice- and bile-derived cell-free DNA (cfDNA) for diagnosing pancreaticobiliary strictures. From October 2020 to February 2022, pancreatic juice or bile was obtained from 50 patients with pancreaticobiliary strictures during endoscopic retrograde cholangiopancreatography. cfDNAs extracted from the samples were analyzed using next-generation sequencing and a cancer gene panel. The obtained cfDNAs, genetic data and clinical information were analyzed for diagnosis. cfDNA concentrations in pancreatic juice were higher in the intraductal papillary mucinous neoplasm group than in the other groups, whereas those in bile were similar in all groups. In pancreatic juice, the sensitivity, specificity and positive and negative predictive values of cfDNA analyses were 33%, 100%, 100% and 71.4%, respectively, whereas those of cytological analyses were 0%, 100%, 0% and 62.5%, respectively. In bile, those of cell-free DNA analyses were 53%, 75%, 89.5% and 28.6%, respectively, whereas those of cytological analyses were 19%, 100%, 100% and 16%, respectively. In conclusion, pancreatic juice- and bile-derived cfDNA is a novel liquid biopsy tool that can diagnose pancreaticobiliary strictures.

Analysis of the Pancreatic Cancer Microbiome Using Endoscopic Ultrasound-Guided Fine-Needle Aspiration-Derived Samples.
Shintaro Nakano, Yasuyuki Kawamoto, Yoshito Komatsu, Rika Saito, Ken Ito, Takahiro Yamamura, Kazuaki Harada, Satoshi Yuki, Kazumichi Kawakubo, Ryo Sugiura, Shin Kato, Koji Hirata, Hajime Hirata, Masahito Nakajima, Ryutaro Furukawa, Yunosuke Takishin, Kousuke Nagai, Isao Yokota, Keisuke H Ota, Shinji Nakaoka, Masaki Kuwatani, Naoya Sakamoto
Pancreas, 51, 4, 351, 357, Ovid Technologies (Wolters Kluwer Health), 01 Apr. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: Most previous studies have analyzed bacteria in tumors using resected pancreatic cancer (PC) tissues, because it is difficult to obtain tissue samples from unresectable advanced PC. We aimed to determine whether minimal tissue obtained by endoscopic ultrasound-guided fine-needle aspiration is useful for microbiome analysis. METHODS: Thirty PC and matched duodenal and stomach tissues (N = 90) were prospectively collected from 30 patients who underwent endoscopic ultrasound-guided fine-needle aspiration. Bacterial DNA was extracted, and 16S rRNA sequencing was performed. The primary outcome was the success rate of bacterial detection in tumors. Bacterial diversity and structure were investigated. RESULTS: The bacterial detection rates were 80%, 100%, and 97% in PC, gastric, and duodenal samples, respectively. Pancreatic cancer tissues showed a lower α-diversity and a significantly different microbial structure than stomach and duodenal tissues. Proteobacteria were more abundant, whereas Firmicutes, Bacteroidetes, and Fusobacteria were less abundant in PC tissues than in stomach and duodenal tissues. Acinetobacter was more abundant in PC tissues than in stomach and duodenal tissues, and Delftia was more frequently detected in resectable PC. CONCLUSIONS: Endoscopic ultrasound-guided fine-needle aspiration samples were valuable for PC microbiome analysis, revealing that the bacterial composition of PC is different from that of the stomach and duodenum.

個別化医療を見据えた消化器診療の現状 超音波内視鏡下穿刺吸引法で得られた検体を用いた膵腫瘍内細菌叢の検討　　　　　　　　　　　　　　　
中野 真太郎, 川本 泰之, 小松 嘉人, 伊藤 憲, 原田 一顕, 結城 敏志, 川久保 和道, 杉浦 諒, 加藤 新, 平田 幸司, 平田 甫, 中島 正人, 古川 龍太郎, 滝新 悠之介, 永井 孝輔, 横田 勲, 太田 圭祐, 中岡 慎治, 桑谷 将城, 坂本 直哉
日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 130回・124回, 36, 36, 日本消化器病学会-北海道支部, Mar. 2022
Japanese

Very urgent endoscopic retrograde cholangiopancreatography is associated with early discharge in patients with non-severe acute cholangitis
Ryo Sugiura, Hirohito Naruse, Yoshiya Yamamoto, Kazuteru Hatanaka, Kenji Kinoshita, Satoshi Abiko, Shuichi Miyamoto, Kazuharu Suzuki, Masayuki Higashino, Risako Kohya, Naoya Sakamoto
Revista Española de Enfermedades Digestivas, 114, 3, 133, 139, Sociedad Espanola de Patologia Digestiva (SEPD), Mar. 2022, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
Scientific journal

Endoscopic Nasobiliary Drainage Comparable with Endoscopic Biliary Stenting as a Preoperative Drainage Method for Malignant Hilar Biliary Obstruction: A Multicenter Retrospective Study
Ryo Sugiura, Masaki Kuwatani, Tsuyoshi Hayashi, Makoto Yoshida, Hideyuki Ihara, Hiroaki Yamato, Manabu Onodera, Akio Katanuma
Digestion, 103, 3, 1, 12, S. Karger {AG}, 26 Jan. 2022, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal, <b><i>Introduction:</i></b> Preoperative endoscopic biliary drainage (PEBD) for malignant hilar biliary obstruction (MHBO) is widely accepted. Recent PEBD consists of endoscopic nasobiliary drainage (ENBD), conventional endoscopic biliary stenting (CEBS) with plastic stents across the papilla, and endoscopic biliary inside stenting (EBIS) with plastic stents above the papilla, while ENBD is the primary procedure in Asian countries. Thus, we aimed to compare the efficacy of ENBD with those of CEBS and EBIS as a means of PEBD for MHBO. <b><i>Methods:</i></b> We retrospectively identified patients with MHBO who underwent upfront surgery between January 2011 and December 2018 in a multicenter setting. The outcome measures were cumulative dysfunction of PEBD, risk factors for PEBD dysfunction, and adverse events. <b><i>Results:</i></b> We analyzed a total of 219 patients, comprising 163 males (74.4%); mean age, 69.7 (±7.6) years; Bismuth-Corlette (BC) classification I, II, IIIa, IIIb, and IV in 68, 49, 43, 30, and 29 patients, respectively; and diagnosis of hilar cholangiocarcinoma and gallbladder cancer in 188 and 31 patients, respectively. PEBD procedures were performed in 160 patients with ENBD, 31 patients with CEBS, and 28 patients with EBIS. PEBD dysfunction occurred in 58 patients (26.5%), and the cumulative dysfunction rates were not significantly different among PEBD methods (<i>p</i> = 0.60). Multivariate analysis showed that BC-IV was significantly associated with the occurrence of PEBD dysfunction (hazard ratio = 2.10, <i>p</i> = 0.02). The adverse event rates were not significantly different among PEBD groups (<i>p</i> = 0.70). <b><i>Conclusion:</i></b> ENBD as a means of PEBD for MHBO is comparable with CEBS and EBIS in rates of dysfunction and adverse events.

Effect of switching from tenofovir disoproxil fumarate to tenofovir alafenamide on lipid profiles in patients with hepatitis B.
Kazuharu Suzuki, Goki Suda, Yoshiya Yamamoto, Satoshi Abiko, Kenji Kinoshita, Shuichi Miyamoto, Ryo Sugiura, Megumi Kimura, Osamu Maehara, Ren Yamada, Takashi Kitagataya, Taku Shigesawa, Masatsugu Ohara, Naoki Kawagishi, Masato Nakai, Takuya Sho, Mitsuteru Natsuizaka, Kenichi Morikawa, Koji Ogawa, Naoya Sakamoto
PloS one, 17, 1, e0261760, e0261760, Public Library of Science (PLoS), 20 Jan. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, For long-term treatment of hepatitis B virus (HBV) infection, switching from tenofovir-disoproxil-fumarate (TDF) to tenofovir-alafenamide (TAF) may prevent renal dysfunction and bone loss. However, the precise effects of this switch on the blood lipid profile remain to be clarified. This is an important issue as TDF is known to have effects on both low- and high-density lipids. Therefore, our retrospective multi-center study aimed to evaluate the effects of switching from TDF to TAF on the lipid profile of patients with HBV infection. Samples were obtained prior to the switch from TDF to TAF and at 6–12 months after TAF initiation. In some cases, additional samples obtained pre- and post-TDF administration were available for analysis. Serum cholesterol levels, including oxidized-low-density lipoprotein (LDL) and non-high-density lipoprotein-cholesterol (HDL-c), and the rate of dyslipidemia, according to the NCEP-ATP III lipid risk classification, were analyzed. The data from 69 patients were analyzed, including 33 patients with pre- and post-TDF-initiation serum samples. Total cholesterol (T-chol), HDL-c, LDL-c, non-HDL-c, and oxidized LDL levels increased significantly after switching to TAF. With regard to sequential changes pre- to post-TAF, TDF was associated with significantly lower serum T-chol, HDL-c, and oxidized LDL-c levels, with T-chol, HDL-c, LDL-c, and oxidized LDL-c levels increasing significantly after the switch. The switch from TDF to TAF was also associated with an increase in the rate of dyslipidemia, from 33% to 39%, with an increase in the rate of severe dyslipidemia of 1.4% and 5.8%, based on T-chol and LDL-c levels. Of note, no cases of severe dyslipidemia were detected pre-TAF treatment. As oxidized LDL-c and non-HDL-c are strongly associated with atherosclerosis development, careful monitoring of lipid is needed after switching from TDF to TAF in this clinical population.

Assessment of postoperative common bile duct stones after endoscopic extraction and subsequent cholecystectomy
Ryo Sugiura, Hideaki Nakamura, Shoichi Horita, Takashi Meguro, Kiyotaka Sasaki, Hidetoshi Kagaya, Tatsuya Yoshida, Hironori Aoki, Takayuki Morita, Miyoshi Fujita, Eiji Tamoto, Masayuki Fukushima, Yoshitomo Ashitate, Takashi Ueno, Akio Tsutaho, Masaki Kuwatani, Naoya Sakamoto
Surgical Endoscopy, 36, 9, 6535, 6542, Springer Science and Business Media {LLC}, 18 Jan. 2022, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
English, Scientific journal

Red dichromatic imaging helps in detecting exposed blood vessels in gastric ulcer induced by endoscopic submucosal dissection.
Shuichi Miyamoto, Ryo Sugiura, Satoshi Abiko, Kazuteru Hatanaka, Yoshiya Yamamoto, Hirohito Naruse, Naoya Sakamoto
Endoscopy, 53, 11, E403-E404, E404, Georg Thieme Verlag {KG}, Nov. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal

Effectiveness of red dichromatic imaging for dissection of the submucosal layer when hematoma is encountered.
Shuichi Miyamoto, Tomohiko R Ohya, Kaori Nishi, Satoshi Abiko, Ryo Sugiura, Yoshiya Yamamoto, Naoya Sakamoto
Endoscopy, 53, 11, E413-E414, E414, Georg Thieme Verlag {KG}, Nov. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal

A new endoscopic fixation method using the commercially available Multi-Clamp: the "clamp technique".
Satoshi Abiko, Shuichi Miyamoto, Ryo Sugiura, Kenji Kinoshita, Kazuteru Hatanaka, Yoshiya Yamamoto, Hirohito Naruse
Endoscopy, 53, 8, E301-E302, E302, Georg Thieme Verlag {KG}, Aug. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal

A spontaneous rupture of lung metastasis from hepatocellular carcinoma after the introduction of lenvatinib
Masayuki Higashino, Ryo Sugiura, Yoshiya Yamamoto, Hirohito Naruse, Naoya Sakamoto
Journal of Gastrointestinal and Liver Diseases, 30, 1, 169, 170, Romanian Society of Gastroenterology and Hepatology, 13 Mar. 2021, [Peer-reviewed], [Corresponding author], [International Magazine]
Scientific journal

Synchronous multiple needle tract seedings of the gastric wall after EUS-guided fine-needle biopsy for pancreatic cancer
Shuhei Hayasaka, Ryo Sugiura, Yoshiya Yamamoto, Hirohito Naruse, Naoya Sakamoto
Gastrointestinal Endoscopy, 92, 5, 1126, 1127, Elsevier {BV}, Nov. 2020, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal

Risk factors for dysfunction of preoperative endoscopic biliary drainage for malignant hilar biliary obstruction
Ryo Sugiura, Masaki Kuwatani, Shin Kato, Kazumichi Kawakubo, Hirofumi Kamachi, Akinobu Taketomi, Takehiro Noji, Keisuke Okamura, Satoshi Hirano, Naoya Sakamoto
Journal of Hepato-Biliary-Pancreatic Sciences, 27, 11, 851, 859, Wiley, Nov. 2020, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal

Gastrointestinal: Endoscopic myotomy for a large rectal tumor with severe fibrosis after treatment of hemorrhoids
S Miyamoto, J Ito, H Naruse, R Sugiura, Y Yamamoto, K Hatanaka, K Kinoshita, M Higashino, S Hayasaka, N Tsuchida, N Shimoyama, N Sakamoto
Journal of Gastroenterology and Hepatology, 35, 7, 1097, 1097, Wiley, Jul. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal

Side-by-side placement of fully covered self-expandable metal stents for malignant distal biliary obstruction.
Koji Hirata, Masaki Kuwatani, Hajime Hirata, Ryo Sugiura, Shin Kato, Naoya Sakamoto
Clinical journal of gastroenterology, 13, 3, 455, 458, Springer Science and Business Media {LLC}, Jun. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, A covered self-expandable metal stent is an efficient and established tool for solution of biliary obstruction. The use of multiple fully covered self-expandable metal stents (SEMSs) for distal malignant biliary obstruction has never been reported. The first case, a 33-year-old female with pancreatic head cancer had low bifurcation of the hepatic ducts and developed obstructive cholangitis by the first single SEMS. The second case, a-59-year-old female with pancreatic head cancer repeatedly underwent biliary decompression by a single SEMS (10-mm, 12-mm), because placed SEMSs were repeatedly dislocated. For solving these problems, we performed side-by-side placement of covered self-expandable metal stents. Finally, side-by-side placement of SEMSs across the papilla for distal malignant biliary obstruction was feasible and available for the two cases.

Long‐term outcomes and risk factors of recurrent biliary obstruction after permanent endoscopic biliary stenting for choledocholithiasis in high‐risk patients
Ryo Sugiura, Hirohito Naruse, Hiroaki Yamato, Taiki Kudo, Yoshiya Yamamoto, Kazuteru Hatanaka, Jun Ito, Kenji Kinoshita, Shuichi Miyamoto, Masayuki Higashino, Shuhei Hayasaka, Naoya Sakamoto
Journal of Digestive Diseases, 21, 4, 246, 251, Wiley, Apr. 2020, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
English, Scientific journal

表在性非乳頭部十二指腸腫瘍に対するエンドサイトスコピーシステムを用いた分類の検討　　　　　　　　　　　　　　　
宮本 秀一, 工藤 俊彦, 石川 麻倫, 小野 尚子, 清水 勇一, 土田 直央, 早坂 秀平, 東野 真幸, 杉浦 諒, 木下 賢治, 伊藤 淳, 畑中 一映, 山本 義也, 成瀬 宏仁, 坂本 直哉
日本消化器病学会北海道支部例会プログラム・抄録集, 126回, 73, 73, 日本消化器病学会-北海道支部, Mar. 2020
Japanese

Endoscopic ultrasound‐guided fine‐needle biopsy for definitive diagnosis of malignant peritoneal mesothelioma
Masayuki Higashino, Ryo Sugiura, Naoya Sakamoto
Digestive Endoscopy, 32, 3, e40, e42, Wiley, Mar. 2020, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal

Hepatobiliary and Pancreatic: Hemosuccus pancreaticus due to an intraductal papillary mucinous neoplasm: A rare cause of obscure gastrointestinal bleeding
R Sugiura, K Kinoshita, H Naruse, Y Yamamoto, K Hatanaka, J Ito, S Miyamoto, M Higashino, S Hayasaka, N Tsuchida, K Nakanishi, S Ueki, M Umehara, N Shimoyama, T Mitsuhashi, N Sakamoto
Journal of Gastroenterology and Hepatology, 35, 3, 363, 363, Wiley, Mar. 2020, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
English, Scientific journal

Gastrointestinal: Endoscopic balloon dilations for an intestinal stricture in a patient with X-linked inhibitor of apoptosis deficiency
Otagiri, S., Sugiura, R., Katsurada, T., Yamanashi, K., Nagashima, K., Sugita, J., Ohnishi, S., Sakamoto, N.
Journal of Gastroenterology and Hepatology (Australia), 34, 11, 1895, 1895, Nov. 2019, [Peer-reviewed], [International Magazine]
Scientific journal

悪性肝門部胆管閉塞症例の術前内視鏡的経鼻胆管ドレナージチューブ閉塞の危険因子解析
杉浦 諒, 桑谷 将城, 平田 甫, 中島 正人, 平田 幸司, 加藤 新, 坂本 直哉
胆道, 33, 3, 493, 493, (一社)日本胆道学会, Oct. 2019
Japanese

膵頭部癌に対する術前内視鏡的胆管ステント留置術の臨床成績
平田 甫, 桑谷 将城, 中島 正人, 平田 幸司, 杉浦 諒, 加藤 新, 坂本 直哉, 浅野 賢道, 平野 聡
胆道, 33, 3, 548, 548, (一社)日本胆道学会, Oct. 2019
Japanese

Correlation between Liver Elasticity by Ultrasound Elastography and Liver Functional Reserve
Sugiura, R., Kuwatani, M., Nishida, M., Hirata, K., Sano, I., Kato, S., Kawakubo, K., Nakai, M., Sho, T., Suda, G., Morikawa, K., Ogawa, K., Sakamoto, N.
Ultrasound in Medicine and Biology, 45, 10, 2704, 2712, Oct. 2019, [Peer-reviewed], [Lead author], [International Magazine]
Scientific journal

Prospective, multicenter, observational study of tissue acquisition through EUS-guided fine-needle biopsy using a 25G Franseen needle
Ryo Sugiura, Masaki Kuwatani, Kei Yane, Yoko Taya, Hideyuki Ihara, Manabu Onodera, Kazunori Eto, Itsuki Sano, Taiki Kudo, Tomoko Mitsuhashi, Akio Katanuma, Naoya Sakamoto
Endoscopic Ultrasound, 8, 5, 321, 321, Medknow, Sep. 2019, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal

Short- and long-term outcomes of a novel transpapillary dilation technique using a diathermic dilator for severe benign bile duct stricture.
Shin Kato, Masaki Kuwatani, Kazumichi Kawakubo, Ryo Sugiura, Koji Hirata, Masahito Nakajima, Hajime Hirata, Hiroshi Kawakami, Naoya Sakamoto
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 31, 4, 448, 452, Jul. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal

Effect of Pancreatic Mass Size on Clinical Outcomes of Endoscopic Ultrasound-Guided Fine-Needle Aspiration.
Ryo Sugiura, Masaki Kuwatani, Koji Hirata, Itsuki Sano, Shin Kato, Kazumichi Kawakubo, Naoya Sakamoto
Digestive diseases and sciences, 64, 7, 2006, 2013, Jul. 2019, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal

内視鏡的乳頭括約筋切開術による出血に対する治療法　　　　　　　　　　　　　　　
平田 甫, 桑谷 将城, 坂本 直哉, 中島 正人, 平田 幸司, 杉浦 諒, 加藤 新
Gastroenterological Endoscopy, 61, Suppl.1, 922, 922, (一社)日本消化器内視鏡学会, May 2019
Japanese

Synchronous multiple pancreatic cancers developed long after severe postendoscopic retrograde cholangiopancreatography pancreatitis.
Ryo Sugiura, Masaki Kuwatani, Koji Hirata, Shin Kato, Yasuyuki Kawamoto, Kazumichi Kawakubo, Tomoko Mitsuhashi, Toshimichi Asano, Satoshi Hirano, Naoya Sakamoto
Endoscopic ultrasound, 8, 3, 213, 214, May 2019, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal

胆道病変に対する超音波内視鏡下穿刺吸引法の臨床成績　　　　　　　　　　　　　　　
平田 甫, 桑谷 将城, 中島 正人, 平田 幸司, 杉浦 諒, 加藤 新, 坂本 直哉
日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 124回・118回, 66, 66, 日本消化器病学会-北海道支部, Mar. 2019
Japanese

Unusual reintervention through a fistula for ampullary penetration of a plastic stent in malignant distal biliary obstruction
Sugiura, R., Kuwatani, M., Sakamoto, N.
Digestive Endoscopy, 31, 2, e48, e49, Mar. 2019, [Peer-reviewed], [Lead author], [International Magazine]
Scientific journal

A Novel Approach for the Genetic Analysis of Biliary Tract Cancer Specimens Obtained Through Endoscopic Ultrasound-Guided Fine Needle Aspiration Using Targeted Amplicon Sequencing.
Koji Hirata, Masaki Kuwatani, Goki Suda, Marin Ishikawa, Ryo Sugiura, Shin Kato, Kazumichi Kawakubo, Naoya Sakamoto
Clinical and translational gastroenterology, 10, 3, e00022, Mar. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal

Mixed ductal-neuroendocrine carcinoma with unique intraductal growth in the main pancreatic duct.
Koji Hirata, Masaki Kuwatani, Tomoko Mitsuhashi, Ryo Sugiura, Shin Kato, Kazumichi Kawakubo, Toru Yamada, Toshimichi Asano, Satoshi Hirano, Naoya Sakamoto
Endoscopic ultrasound, 8, 2, 129, 130, Mar. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal

Hepatobiliary and Pancreatic: Pancreatic cancer with elevated serum IgG4 level due to multiple myeloma mimicking localized autoimmune pancreatitis
S Kato, M Kuwatani, K Kawakubo, R Sugiura, K Hirata, S Tanikawa, T Mitsuhashi, S Shiratori, N Sakamoto
Journal of Gastroenterology and Hepatology, 33, 7, 1310, 1310, Wiley, Jul. 2018, [Peer-reviewed], [International Magazine]
Scientific journal

Effects of human amnion-derived mesenchymal stem cells and conditioned medium in rats with sclerosing cholangitis
Sugiura, R., Ohnishi, S., Ohara, M., Ishikawa, M., Miyamoto, S., Onishi, R., Yamamoto, K., Kawakubo, K., Kuwatani, M., Sakamoto, N.
American Journal of Translational Research, 10, 7, 2102, 2114, Jul. 2018, [Peer-reviewed], [Lead author], [International Magazine]
Scientific journal

Successful endoscopic sphincterotomy for choledocholithiasis in a patient with severe hemophilia A and inhibitors.
Ryo Sugiura, Masaki Kuwatani, Kazumichi Kawakubo, Itsuki Sano, Shin Kato, Tomoyuki Endo, Naoya Sakamoto
Clinical journal of gastroenterology, 11, 3, 188, 192, Jun. 2018, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal

遠位胆管金属ステント閉塞への対処 double stentingとpigtail stentによる工夫　　　　　　　　　　　　　　　
平田 幸司, 桑谷 将城, 杉浦 諒, 加藤 新, 川久保 和道, 坂本 直哉
Gastroenterological Endoscopy, 60, Suppl.1, 742, 742, (一社)日本消化器内視鏡学会, Apr. 2018
Japanese

肝門部領域胆管癌の胆管水平方向進展診断における経乳頭的鉗子生検の診断能　　　　　　　　　　　　　　　
杉浦 諒, 桑谷 将城, 平田 幸司, 加藤 新, 川久保 和道, 坂本 直哉
日本消化器病学会雑誌, 115, 臨増総会, A301, A301, (一財)日本消化器病学会, Mar. 2018
Japanese

Direct puncture of the ampulla as a modified Endoscopic ultrasound-guided rendezvous technique
Kawakubo, K., Kuwatani, M., Kato, S., Sugiura, R., Sano, I., Sakamoto, N.
Endoscopic Ultrasound, 7, 2, 133, 134, Mar. 2018, [Peer-reviewed], [International Magazine]
Scientific journal

Gastrointestinal: Transurethral endoscopic retrograde pancreatography
Kawakubo, K., Kuwatani, M., Shimamura, T., Yamashita, K., Goto, R., Watanabe, M., Koshizuka, Y., Kawamura, N., Iwami, D., Hotta, K., Sano, I., Sugiura, R., Kato, S., Shinohara, N., Taketomi, A., Sakamoto, N.
Journal of Gastroenterology and Hepatology (Australia), 32, 11, 1791, 1791, Wiley, Nov. 2017, [Peer-reviewed], [International Magazine]
Scientific journal

転移性および原発性病変による肝門部悪性胆管狭窄に対する内視鏡的胆管ドレナージ術の臨床成績
杉浦 諒, 桑谷 将城, 佐野 逸紀, 加藤 新, 川久保 和道, 坂本 直哉
胆道, 31, 3, 566, 566, (一社)日本胆道学会, Aug. 2017
Japanese

Effect of endoscopic transpapillary biliary drainage with/without endoscopic sphincterotomy on post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with biliary stricture (E-BEST) : a protocol for a multicentre randomised controlled trial
Kato Shin, Kuwatani Masaki, Sugiura Ryo, Sano Itsuki, Kawakubo Kazumichi, Ono Kota, Sakamoto Naoya
BMJ Open, 7, 8, e017160, BMJ Publishing Group, Aug. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal

高度悪性胆道狭窄に対する経乳頭的通電拡張術の有効性と諸問題　　　　　　　　　　　　　　　
加藤 新, 桑谷 将城, 杉浦 諒, 佐野 逸紀, 川久保 和道, 坂本 直哉
Gastroenterological Endoscopy, 59, Suppl.1, 993, 993, (一社)日本消化器内視鏡学会, Apr. 2017
Japanese

Rescue technique using a diathermic dilator for an unremovable stent in malignant perihilar biliary obstruction
Sugiura, R., Kawakami, H., Ehira, N., Iwanaga, I., Uebayashi, M., Kuwatani, M., Sakamoto, N.
Endoscopy, 49, S 01, E42, E45, Feb. 2017, [Peer-reviewed], [Lead author], [International Magazine]
Scientific journal

Hepatobiliary and Pancreatic: A rare case of a well-differentiated neuroendocrine tumor in the bile duct with spontaneous regression diagnosed by EUS-FNA
Sano, I., Kuwatani, M., Sugiura, R., Kato, S., Kawakubo, K., Ueno, T., Nakanishi, Y., Mitsuhashi, T., Hirata, H., Haba, S., Hirano, S., Sakamoto, N.
Journal of Gastroenterology and Hepatology (Australia), 32, 1, 11, 11, Jan. 2017, [Peer-reviewed], [International Magazine]
Scientific journal

胆道疾患に対するInterventional EUSの現在、およびX線透視の活用—特集 低被ばく進むX線撮影装置
川久保 和道, 桒谷 将城, 杉浦 諒, 永井 孝輔, 岸 法磨, 米村 洋輝, 野澤 俊一郎, 坂本 直哉, 映像情報medical : a monthly journal of medical imaging and information, 55, 2, 12, 16, Feb. 2023
産業開発機構映像情報メディカル編集部, Japanese

【Biliary access大辞典】EUSガイド下biliary access EUS-RVテクニック
川久保 和道, 桑谷 将城, 杉浦 諒, 加藤 新, 平田 幸司, 平田 甫, 中島 正人, 坂本 直哉, 胆と膵, 39, 臨増特大, 1117, 1121, Nov. 2018
医学図書出版(株), Japanese

【あれから5年 抗血栓薬-とめない覚悟と勇気】抗血栓薬服用者におけるEUS-FNAおよびinterventional EUSの留意点
川久保 和道, 桑谷 将城, 杉浦 諒, 加藤 新, 平田 幸司, 坂本 直哉, 消化器内視鏡, 30, 10, 1474, 1479, Oct. 2018
(株)東京医学社, Japanese

長期予後改善をめざす自己免疫性肝疾患の基礎と臨床 薬剤誘発硬化性胆管炎ラットに対するヒト羊膜由来間葉系幹細胞の治療効果　　　　　　　　　　　　　　　
杉浦 諒, 大西 俊介, 坂本 直哉, 日本消化器病学会雑誌, 115, 臨増大会, A606, A606, Oct. 2018
(一財)日本消化器病学会, Japanese

肝門部領域胆管癌の胆管水平方向進展診断における経乳頭的鉗子生検の診断能　　　　　　　　　　　　　　　
杉浦 諒, 桑谷 将城, 平田 幸司, 加藤 新, 川久保 和道, 坂本 直哉, 日本消化器病学会雑誌, 115, 臨増総会, A301, A301, Apr. 2018
(一財)日本消化器病学会, Japanese

超音波検査を用いた肝予備能評価の検討　　　　　　　　　　　　　　　
杉浦 諒, 桑谷 将城, 西田 睦, 平田 幸司, 加藤 新, 川久保 和道, 坂本 直哉, 超音波医学, 45, Suppl., S688, S688, Apr. 2018
(公社)日本超音波医学会, Japanese

【膵疾患に対する内視鏡治療の新展開】 膵切除後膵液瘻に対する内視鏡治療
桑谷 将城, 川久保 和道, 加藤 新, 杉浦 諒, 平田 幸司, 平野 聡, 坂本 直哉, 消化器・肝臓内科, 2, 6, 625, 631, Dec. 2017
(有)科学評論社, Japanese

胆管挿管困難例に対するEUS-guided rendezvous technique—EUS-guided rendezvous technique for difficult biliary cannulation—特集 Interventional EUSの最新情報 : 適応,手技,デバイス
川久保 和道, 桒谷 将城, 加藤 新, 杉浦 諒, 平田 幸司, 坂本 直哉, 消化器・肝臓内科 = Gastroenterology & hepatology / 消化器・肝臓内科編集委員会 編, 2, 3, 274, 281, Sep. 2017
科学評論社, Japanese

The Efficacy and Safety of a Novel Transpapillary Dilation Technique With a Diathermic Catheter for Severe Malignant Bile Duct Stricture
Shin Kato, Masaki Kuwatani, Ryo Sugiura, Itsuki Sano, Kazumichi Kawakubo, Naoya Sakamoto, GASTROINTESTINAL ENDOSCOPY, 85, 5, AB631, AB632, May 2017
English, Summary international conference

Endoscopic Reintervention Following Multiple Metallic Stent Placement for Hilar Malignant Biliary Stricture
Kazumichi Kawakubo, Masaki Kuwatani, Itsuki Sano, Ryo Sugiura, Shin Kato, Naoya Sakamoto, GASTROINTESTINAL ENDOSCOPY, 85, 5, AB617, AB617, May 2017
English, Summary international conference

【今IPMNをどう診るか】 サーベイランスをめぐる諸問題 IPMNの予後を決める因子は?
川久保 和道, 多田 稔, 桑谷 将城, 佐野 逸紀, 杉浦 諒, 加藤 新, 坂本 直哉, 肝・胆・膵, 74, 4, 597, 600, Apr. 2017
(株)アークメディア, Japanese

A case of bile duct neuroendocrine tumor preoperatively diagnosed by endoscopic ultrasonography-guided fine-needle aspiration biopsy
Shin Kato, Masaki Kuwatani, Ryo Sugiura, Itsuki Sano, Kazumichi Kawakubo, Naoya Sakamoto, Yoshitsugu Nakanishi, Satoshi Hirano, Takashi Ueno, Tomoko Mitsuhashi, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 31, 231, 231, Nov. 2016
English, Summary international conference

PLASTIC STENTS VS. LUMEN-APPOSING METAL STENT FOR ENDOSCOPIC ULTRASOUND-GUIDED DRAINAGE OF PANCREATIC PSUEDOCYSTS: A MULTICENTER, RANDOMISED CONTROLLED, NON-INFERIORITY TRIAL (WONDER-02)　　　　　　　　　　　　　　　
Tomotaka Saito, Takeshi Ogura, Nao Fujimori, Hiroshi Ohyama, Kazuyuki Matsumoto, Nobuhiko Hayashi, Toshio Fujisawa, Atsuhiro Masuda, Masaki Kuwatani, Shinpei Doi, Mamoru Takenaka, Keisuke Iwata, Hideyuki Shiomi, Hirofumi Kogure, Tadahisa Inoue, Saburo Matsubara, Shinichi Hashimoto, Hideki Kamada, Masayuki Kitano, Toshiyasu Shiratori, Tsuyoshi Hamada, Kosuke Kashiwabara, Saori Ueno, Atsushi Okuda, Kazuhide Matsumoto, Keijiro Ueda, Koji Takahashi, Motoyasu Kan, Ryosuke Sato, Takuji Iwashita, Sho Takahashi, Masahiro Tsujimae, Ryo Sugiura, Nobuhiro Katsukura, Shunsuke Omoto, Yuhei Iwasa, Ryota Nakano, Kei Saito, Rena Kitano, Kentaro Suda, Makoto Hinokuchi, Ryota Nakabayashi, Takashi Tamura, So Nakaji, Akinori Maruta, Tsuyoshi Mukai, Reiko Yamada, Hiroyuki Isayama, Ichiro Yasuda, Yousuke Nakai
Digestive Disease Week 2025, 06 May 2025, Oral presentation
[International presentation]

IMMEDIATE NECROSECTOMY VS. DRAINAGE-ORIENTED STEP-UP APPROACH AFTER ENDOSCOPIC ULTRASOUND-GUIDED DRAINAGE OF WALLED-OFF NECROSIS—SUBGROUP ANALYSES OF A MULTICENTER RANDOMISED CONTROLLED TRIAL (WONDER-01)　　　　　　　　　　　　　　　
Tomotaka Saito, Toshio Fujisawa, Takeshi Ogura, Masaki Kuwatani, Hiroshi Ohyama, Mamoru Takenaka, Shinpei Doi, Keisuke Iwata, Shinichi Hashimoto, Hideki Kamada, Takuji Iwashita, Hideyuki Shiomi, Atsuhiro Masuda, Saburo Matsubara, Nobuhiko Hayashi, Akinori Maruta, Hirofumi Kogure, Tadahisa Inoue, Reiko Yamada, Toshiyasu Shiratori, Tsuyoshi Hamada, Saori Ueno, Atsushi Okuda, Sho Takahashi, Ryo Sugiura, Kazumichi Kawakubo, Koji Takahashi, Motoyasu Kan, Shunsuke Omoto, Tomohiro Yamazaki, Nobuhiro Katsukura, Mitsuru Okuno, Makoto Hinokuchi, Daisuke Namima, Shinya Uemura, Ryota Nakano, Masahiro Tsujimae, Arata Sakai, Kentaro Suda, Kensaku Yoshida, Kei Saito, Rena Kitano, Kenji Nose, So Nakaji, Tsuyoshi Mukai, Kazunari Nakahara, Kenji Chinen, Hiroyuki Isayama, Ichiro Yasuda, Yousuke Nakai
Digestive Disease Week 2025, 06 May 2025, Oral presentation
[International presentation]

EFFICACY OF PERFUSION COMPUTED TOMOGRAPHY IN EARLY PREDICTION OF POST-ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY PANCREATITIS　　　　　　　　　　　　　　　
Masaki Kuwatani, Shunichiro Nozawa, Ryosuke Shimura, Ryo Sugiura, Kazumichi Kawakubo, Hiroki Yonemura, Yusuke Sakuhara, Kohsuke Kudo, Naoya Sakamoto
Digestive Disease Week 2025, 05 May 2025, Oral presentation
[International presentation]

SUBCUTANEOUS ADIPOSE TISSUE RADIODENSITY AS A PREDICTOR OF POOR PROGNOSIS IN ADVANCED BILIARY TRACT CANCER　　　　　　　　　　　　　　　
Ryo Sugiura, Masaki Kuwatani, Kazumichi Kawakubo, Yasuyuki Kawamoto, Kazuaki Harada, Masatsugu Ohara, Hiroki Yonemura, Shunichiro Nozawa, Shoya Shiratori, Soichiro Oda, Naoya Sakamoto
Digestive Disease Week 2025, 04 May 2025, Poster presentation
[International presentation]

進行胆道癌の生命予後不良の予測因子としての皮下脂肪組織放射線密度　　　　　　　　　　　　　　　
杉浦 諒, 桒谷 将城, 川本 泰之, 原田 一顕, 小田 総一郎, 白鳥 翔也, 野澤 俊一郎, 米村 洋輝, 川久保 和道, 坂本 直哉
第111回日本消化器病学会総会, 25 Apr. 2025, Public symposium
[Domestic Conference]

胆道癌患者における術前骨格筋量減少の危険因子解析　　　　　　　　　　　　　　　
杉浦 諒, 桒谷 将城, 小田 総一郎, 白鳥 翔也, 野澤 俊一郎, 米村 洋輝, 川久保 和道, 坂本 直哉
第60回日本胆道学会学術集会, 11 Oct. 2024, Oral presentation
[Domestic Conference]

Comparison of endoscopic biliary inside stenting with endoscopic nasobiliary drainage as the initial drainage for malignant hilar biliary obstruction　　　　　　　　　　　　　　　
Ryo Sugiura, Masaki Kuwatani, Naoya Sakamoto
第60回日本胆道学会学術集会, 10 Oct. 2024, Oral presentation
[Domestic Conference]

胆管Fully covered self-expandable metal stent留置併用膵管stent閉塞に起因した膵液瘻の一例　　　　　　　　　　　　　　　
米村 洋輝, 杉浦 諒, 白鳥 翔也, 小田 総一郎, 野澤 俊一郎, 川久保 和道, 桒谷 将城, 坂本 直哉
第129回 日本消化器内視鏡学会北海道支部例会, 31 Aug. 2024, Oral presentation

IPMN患者における骨格筋量減少の膵発癌に与える影響　　　　　　　　　　　　　　　
小田 総一郎, 川久保 和道, 白鳥 翔也, 野澤 俊一郎, 米村 洋輝, 岸 法磨, 杉浦 諒, 桑谷 将城, 坂本 直哉
第55回日本膵臓学会大会, 26 Jul. 2024, Public symposium
[Domestic Conference]

膵管狭窄/拡張に対する内視鏡的逆行性膵管造影下ブラシ細胞診と連続膵液細胞診の診断能の比較　　　　　　　　　　　　　　　
杉浦 諒, 桒谷 将城, 白鳥 翔也, 小田 総一郎, 野澤 俊一郎, 米村 洋輝, 岸 法磨, 川久保 和道, 坂本 直哉
第107回日本消化器内視鏡学会総会, 30 May 2024, Poster presentation
[Domestic Conference]

硝子化により非典型的な所見を呈した膵神経内分泌腫瘍の一例　　　　　　　　　　　　　　　
白鳥 翔也, 杉浦 諒, 桒谷 将城, 小田 総一郎, 野澤 俊一郎, 米村 洋輝, 岸 法磨, 川久保 和道, 坂本 直哉, 松井 あや, 平野 聡, 頼永 聡子, 三橋 智子
第134回日本消化器病学会北海道支部例会, 02 Mar. 2024, Oral presentation
[Domestic Conference]

IgG4関連疾患に随伴した腸腰筋病変の1例　　　　　　　　　　　　　　　
北野 翔一, 杉浦 諒, 桒谷 将城, 川久保 和道, 岸 法磨, 野澤 俊一郎, 米村 洋輝, 白鳥 翔也, 小田 総一郎, 坂本 直哉
第300回日本内科学会北海道地方会例会, Feb. 2024

非切除十二指腸乳頭部癌症例における胆管ステント機能不全の危険因子解析：多施設共同後方視的観察研究　　　　　　　　　　　　　　　
杉浦 諒, 桒谷 将城, 金 俊文, 松本 隆祐, 池田 裕貴, 佐野 逸紀, 平田 幸司, 吉田 真誠, 柾木 喜晴, 小野 道洋, 平田 甫, 大和 弘明, 小野寺 学, 中村 英明, 多谷 容子, 江平 宣起, 中島 正人, 潟沼 朗生
Japan Digestive Disease Week 2023, 02 Nov. 2023, Poster presentation
[Domestic Conference]

十二指腸液中のメタボローム解析による胆道良悪性疾患の鑑別　　　　　　　　　　　　　　　
岸 法磨, 桑谷 将城, 野澤 俊一郎, 米村 洋輝, 杉浦 諒, 川久保 和道, 坂本 直哉
第59回日本胆道学会学術集会, 14 Sep. 2023, Poster presentation

胆膵疾患の外科的切除後合併症におけるバルーン内視鏡補助下胆道治療の現状　　　　　　　　　　　　　　　
米村 洋輝, 桑谷 将城, 野澤 俊一郎, 岸 法磨, 永井 孝輔, 杉浦 諒, 川久保 和道, 坂本 直哉
第59回日本胆道学会学術集会, 14 Sep. 2023, Poster presentation

肝門部領域胆管癌の術前超音波内視鏡検査の臨床的意義　　　　　　　　　　　　　　　
杉浦 諒, 桑谷 将城, 坂本 直哉
第59回日本胆道学会学術集会, 14 Sep. 2023, Public symposium

Nakazawa分類Type 2/3/4 IgG4関連硬化性胆管炎の臨床的特徴　　　　　　　　　　　　　　　
杉浦 諒, 桒谷 将城, 野澤 俊一郎, 米村 洋輝, 岸 法磨, 永井 孝輔, 川久保 和道, 坂本 直哉
第109回日本消化器病学会総会, 08 Apr. 2023, Oral presentation
[Domestic Conference]

膵周囲液体貯留（PFC）に対するLumen apposing metal stent（LAMS）を用いた径消化管的超音波内視鏡下ドレナージの臨床成績　　　　　　　　　　　　　　　
米村 洋輝, 桑谷 将城, 野澤 俊一郎, 岸 法磨, 永井 孝輔, 杉浦 諒, 川久保 和道, 坂本 直哉
第132回日本消化器病学会 北海道支部例会, 04 Mar. 2023, Oral presentation

急性胆管炎合併急性胆嚢炎に対する経鼻胆道ドレナージチューブの新規使用法が有効であった1例　　　　　　　　　　　　　　　
岸 法磨, 桑谷 将城, 野澤 俊一郎, 米村 洋輝, 永井 孝輔, 杉浦 諒, 川久保 和道, 坂本 直哉
第126回日本消化器内視鏡学会 北海道支部例会, 04 Mar. 2023, Oral presentation

悪性肝門部胆管閉塞に対する術前内視鏡的胆道ドレナージの機能不全リスクの検討　　　　　　　　　　　　　　　
杉浦 諒, 桒谷 将城, 坂本 直哉
第58回日本胆道学会学術集会, Oct. 2022, Public symposium

胆管空腸吻合術後の胆管に棒状構造物が迷入した4例　　　　　　　　　　　　　　　
米村 洋輝, 桑谷 将城, 野澤俊一郎, 岸 法磨, 永井 孝輔, 杉浦 諒, 川久保和道, 坂本 直哉
第131回日本消化器病学会北海道支部例会, Sep. 2022, Oral presentation

胆膵疾患に対する外科切除症例における胆膵バルーン内視鏡治療の現状　　　　　　　　　　　　　　　
杉浦 諒, 桒谷 将城, 野澤 俊一郎, 米村 洋輝, 岸 法磨, 永井 孝輔, 川久保 和道, 坂本 直哉
第131回日本消化器病学会北海道支部例会, Sep. 2022, Public symposium

内視鏡的胆管結石除去術+胆嚢摘出術直後の術後胆管結石の検討　　　　　　　　　　　　　　　
杉浦 諒, 中村 英明, 堀田 彰一
第108回日本消化器病学会総会, Apr. 2022, Public symposium

超音波内視鏡下穿刺吸引法で得られた検体を用いた膵腫瘍内細菌叢の検討　　　　　　　　　　　　　　　
中野 真太, 川本 泰之, 小松 嘉人, 伊藤 憲, 原田 一顕, 結城 敏志, 川久保 和道, 杉浦 諒, 加藤 新, 平田 幸司, 平田 甫, 中島 正人, 古川 龍太郎, 滝新 悠之介, 永井 孝輔, 横田 勲, 太田 圭祐, 中岡 慎治, 桒谷 将城, 坂本 直哉
第130回日本消化器病学会北海道支部例会, Mar. 2022, Public symposium

胆管結石+胆嚢結石に対する内視鏡+外科治療直後のpostoperative stoneの検討　　　　　　　　　　　　　　　
杉浦 諒, 中村 英明, 青木 敬則, 吉田 達也, 加賀谷 英俊, 佐々木 清貴, 目黒 高志, 堀田 彰一
第130回日本消化器病学会北海道支部例会, Mar. 2022, Oral presentation

悪性肝門部胆管閉塞に対する術前内視鏡的経鼻胆道ドレナージと内視鏡的ステント留置術との比較検討：多施設共同後向き研究　　　　　　　　　　　　　　　
杉浦 諒, 桒谷 将城, 林 毅, 吉田 真誠, 庵原 秀之, 大和 弘明, 小野寺 学, 潟沼 朗生
第101回日本消化器内視鏡学会総会, May 2021, Oral presentation

軽症・中等症急性胆管炎に対する超緊急内視鏡的胆道ドレナージの有用性の検討　　　　　　　　　　　　　　　
杉浦 諒, 山本 義也, 成瀬 宏仁
第101回日本消化器内視鏡学会総会, May 2021, Public symposium

C型非代償性肝硬変及びDAA不成功例に対するソフォスブビル / ベルパタスビル療法の有効性と安全性の検討　　　　　　　　　　　　　　　
鈴木和治, 山本義也, 甲谷理紗子, 杉浦諒, 宮本秀一, 木下賢治, 安孫子怜史, 畑中一映, 成瀬宏仁
第128回日本消化器病学会北海道支部例会, Mar. 2021, Oral presentation

肝細胞癌に対して分子標的薬の投与開始後7日目で腫瘍破裂をきたした一剖検例　　　　　　　　　　　　　　　
甲谷理紗子, 山本義也, 鈴木和治, 杉浦諒, 宮本秀一, 木下賢治, 安孫子怜史, 畑中一映, 成瀬宏仁, 櫛引英恵, 棟方哲, 下山則彦
第128回日本消化器病学会北海道支部例会, Mar. 2021, Oral presentation

切除不能肝細胞癌に対するTKI導入症例の検討　　　　　　　　　　　　　　　
山本義也, 甲谷理紗子, 鈴木和治, 杉浦諒, 宮本秀一, 安孫子怜史, 木下賢治, 畑中一映, 成瀬宏仁
第128回日本消化器病学会北海道支部例会, Mar. 2021, Oral presentation

C型肝炎に対するDAA治療によるSVR後の肝発癌状況　　　　　　　　　　　　　　　
山本義也, 東野真幸, 甲谷理紗子, 鈴木和治, 杉浦諒, 宮本秀一, 木下賢治, 安孫子怜史, 畑中一映, 成瀬宏仁
第127回日本消化器病学会北海道支部例会, Sep. 2020, Oral presentation

潰瘍性大腸炎における便中カルプロテクチンと体外式腹部超音波検査による病勢評価有用性の検討　　　　　　　　　　　　　　　
木下賢治, 高谷理沙子, 東野真幸, 鈴木和治, 杉浦諒, 宮本秀一, 安孫子さとし, 畑中一映, 山本義也, 成瀬宏仁
第127回日本消化器病学会北海道支部例会, Sep. 2020, Public symposium

高齢者における総胆管結石に対する恒久的内視鏡的胆道ステント留置術の長期成績と機能不全の危険因子解析　　　　　　　　　　　　　　　
杉浦 諒, 成瀬 宏仁, 早坂 秀平, 東野 真幸, 宮本 秀一, 木下 賢治, 伊藤 淳, 畑中 一映, 山本 義也
第99回日本消化器内視鏡学会総会, May 2020, Oral presentation

総胆管結石に対する恒久的内視鏡的胆道ステント留置術の長期成績と機能不全の危険因子解析　　　　　　　　　　　　　　　
杉浦諒, 早坂秀平, 東野真幸, 宮本秀一, 木下賢治, 伊藤淳, 畑中一映, 山本義也, 成瀬宏仁
第126回日本消化器病学会北海道支部例会, Mar. 2020, Public symposium

表在性非乳頭部十二指腸腫瘍に対するエンドサイトスコピーシステムを用いた分類の検討　　　　　　　　　　　　　　　
宮本秀一, 工藤俊彦, 石川麻倫, 小野尚子, 清水勇一, 土田直央, 早坂秀平, 東野真幸, 杉浦諒, 木下賢治, 伊藤淳, 畑中一映, 山本義也, 成瀬宏仁, 坂本直哉
第120回日本消化器内視鏡学会北海道支部例会, Mar. 2020, Public symposium

当科における胃癌免疫チェックポイント阻害剤治療症例の検討　　　　　　　　　　　　　　　
畑中一映, 早坂秀平, 土田直央, 東野真幸, 杉浦諒, 宮本秀一, 木下賢治, 伊藤淳, 山本義也, 成瀬宏仁
第126回日本消化器病学会北海道支部例会, Mar. 2020, Oral presentation

当院におけるC型肝硬変症例に対するDAA治療の現状　　　　　　　　　　　　　　　
山本義也, 早坂秀平, 土田直央, 東野真幸, 杉浦諒, 宮本秀一, 木下賢治, 伊藤淳, 畑中一映, 成瀬宏仁
第126回日本消化器病学会北海道支部例会, Mar. 2020, Oral presentation

膵管出血を来した浸潤癌を伴う膵管内乳頭粘液性腫瘍の1例　　　　　　　　　　　　　　　
早坂秀平, 木下賢治, 杉浦諒, 土田直央, 東野真幸, 宮本秀一, 伊藤淳, 畑中一映, 山本義也, 成瀬宏仁, 下山則彦, 三橋智子
第126回日本消化器病学会北海道支部例会, Mar. 2020, Oral presentation

膵頭部癌に対する術前内視鏡的胆管ステント留置術の臨床成績　　　　　　　　　　　　　　　
平田甫, 桒谷 将城, 中島正人, 平田幸司, 杉浦諒, 加藤新, 坂本直哉, 浅野賢道, 平野聡
第55回日本胆道学会学術集会, Oct. 2019, Oral presentation

悪性肝門部胆管閉塞症例の術前内視鏡的経鼻胆管ドレナージチューブ閉塞の危険因子解析　　　　　　　　　　　　　　　
杉浦 諒, 桒谷 将城, 平田 甫, 中島 正人, 平田 幸司, 加藤 新, 坂本 直哉
第55回日本胆道学会学術集会, Oct. 2019, Oral presentation

Lenvatinib投与後早期に腫瘍内血流低下を確認し得た進行肝細胞癌症例の検討　　　　　　　　　　　　　　　
山本義也, 早坂秀平, 東野真幸, 杉浦諒, 宮本秀一, 木下賢治, 伊藤淳, 畑中一映, 成瀬宏仁
第125回日本消化器病学会北海道支部例会, Sep. 2019, Oral presentation

当院における進行肝癌に対する肝動注化学療法の検討　　　　　　　　　　　　　　　
山本義也, 早坂秀平, 東野真幸, 杉浦諒, 宮本秀一, 木下賢治, 伊藤淳, 畑中一映, 成瀬宏仁
第125回日本消化器病学会北海道支部例会, Sep. 2019, Oral presentation

Franseen形状25G穿刺針を用いた超音波内視鏡ガイド下穿刺吸引生検における病理組織学的検討 : 多施設共同前向き観察研究　　　　　　　　　　　　　　　
杉浦諒, 桒谷将城, 矢根圭, 多谷容子, 庵原秀之, 小野寺学, 江藤和範, 佐野逸紀, 工藤大樹, 三橋智子, 潟沼朗生, 坂本直哉
第105回日本消化器病学会総会, May 2019, Oral presentation

胆道病変に対する超音波内視鏡下穿刺吸引法の臨床成績　　　　　　　　　　　　　　　
平田甫, 桒谷将城, 中島正人, 平田幸司, 杉浦諒, 加藤新, 坂本直哉
第118回日本消化器内視鏡学会北海道支部例会, Mar. 2019, Oral presentation

A prospective multicenter observational cohort study of tissue acquisition by endoscopic ultrasound-guided fine-needle biopsy using a 25-gauge franseen needle　　　　　　　　　　　　　　　
Ryo Sugiura, Masaki Kuwatani, Kei Yane, Yoko Taya, Hideyuki Ihara, Manabu Onodera, Kazunori Eto, Itsuki Sano, Taiki Kudo, Tomoko Mitsuhashi, Akio Katanuma, Naoya Sakamoto
Asian Pacific Digestive Week 2018, Nov. 2018, Poster presentation

Long-term clinical outcomes of endoscopic deployment of multiple metal stents for malignant hilar biliary obstruction　　　　　　　　　　　　　　　
Ryo Sugiura, Masaki Kuwatani, Naoya Sakamoto
Japan Digestive Disease Week 2018, Nov. 2018, Public symposium

薬剤誘発硬化性胆管炎ラットに対するヒト羊膜由来間葉系幹細胞の治療効果　　　　　　　　　　　　　　　
杉浦諒, 大西俊介, 坂本直哉
Japan Digestive Disease Week 2018, Nov. 2018, Public symposium

Amnion-derived mesenchymal stem cells ameliorates sclerosing cholangitis in rats　　　　　　　　　　　　　　　
Ryo Sugiura, Shunsuke Ohnishi, Masatsugu Ohara, Marin Ishikawa, Shuichi Miyamoto, Reizo Onishi, Koji Yamamoto, Kazumichi Kawakubo, Masaki Kuwatani, Naoya Sakamoto
United European Gastroenterology Week 2018, Oct. 2018, Poster presentation

肝門部領域胆管癌の術前内視鏡的経鼻胆管ドレナージチューブ閉塞の危険因子解析　　　　　　　　　　　　　　　
杉浦諒, 桒谷将城, 坂本直哉
第54回日本胆道学会学術集会, Sep. 2018, Public symposium

25G franseen形状穿刺針を用いた超音波内視鏡ガイド下穿刺吸引生検に関する多施設共同前向き観察研究　　　　　　　　　　　　　　　
杉浦諒, 桒谷将城, 矢根圭, 多谷容子, 庵原秀之, 小野寺学, 江藤和範, 佐野逸紀, 工藤大樹, 三橋智子, 潟沼朗生, 坂本直哉
第117回日本消化器内視鏡学会北海道支部例会, Sep. 2018, Oral presentation

GC療法に不応・不耐の胆道癌に対するS-1療法　　　　　　　　　　　　　　　
村中徹人, 小松嘉人, 中野真太, 澤田憲太, 川本泰之, 中積宏之, 結城敏志, 平田甫, 中島正人, 平田幸司, 杉浦諒, 加藤新, 桒谷将城, 坂本直哉
第123回日本消化器病学会北海道支部例会, Sep. 2018, Public symposium

内視鏡的乳頭括約筋切開術後出血に対する治療法　　　　　　　　　　　　　　　
平田甫, 桒谷将城, 中島正人, 平田幸司, 杉浦諒, 加藤新, 坂本直哉
第117回日本消化器内視鏡学会北海道支部例会, Sep. 2018, Oral presentation

血液凝固障害に併存する総胆管結石の内視鏡治療－重症血友病Aに合併した総胆管結石の1例　　　　　　　　　　　　　　　
杉浦 諒, 桒谷 将城, 平田 甫, 中島正人, 平田幸司, 加藤 新, 川久保和道, 坂本直哉
第283回日本内科学会北海道地方会例会, Jul. 2018, Oral presentation

超音波検査を用いた肝予備能評価の検討　　　　　　　　　　　　　　　
杉浦 諒, 桒谷 将城, 西田 睦, 平田 幸司, 加藤 新, 川久保 和道, 坂本 直哉
日本超音波医学会第91回学術集会, Jun. 2018, Oral presentation

肝門部領域胆管癌の胆管水平方向進展診断における経乳頭的鉗子生検の診断能　　　　　　　　　　　　　　　
杉浦諒, 桒谷将城, 平田幸司, 加藤新, 川久保和道, 坂本直哉
第104回日本消化器病学会総会, Apr. 2018, Oral presentation

悪性遠位胆管狭窄に対する細径金属ステントを用いたdouble stenting　　　　　　　　　　　　　　　
平田幸司, 桒谷将城, 杉浦諒, 加藤新, 川久保和道, 坂本直哉
第122回日本消化器病学会北海道支部例会, Mar. 2018

主膵管非閉塞の悪性胆道狭窄に対するメタリックステント留置時の乳頭括約筋切開術付加の効果　　　　　　　　　　　　　　　
加藤新, 桒谷将城, 川久保和道, 杉浦諒, 平田幸司, 坂本直哉
第116回日本消化器内視鏡学会北海道支部例会, Mar. 2018, Oral presentation

超音波エラストグラフィによる肝弾性度と肝予備能との相関性の検討　　　　　　　　　　　　　　　
杉浦 諒, 桒谷 将城, 西田 睦, 平田 幸司, 加藤 新, 川久保 和道, 坂本 直哉
日本超音波医学会第47回北海道地方会学術集会, Dec. 2017, Oral presentation

Long-term clinical outcomes of endoscopic deployment of multiple metal stents for malignant hilar biliary obstruction　　　　　　　　　　　　　　　
Ryo Sugiura, Masaki Kuwatani, Koji Hirata, Itsuki Sano, Shin Kato, Kazumichi Kawakubo, Naoya Sakamoto
Asian Pacific Digestive Week 2017, Sep. 2017, Poster presentation

転移性および原発性病変による肝門部悪性胆管狭窄に対する内視鏡的胆管ドレナージ術の臨床成績　　　　　　　　　　　　　　　
杉浦諒, 桒谷将城, 佐野逸紀, 加藤新, 川久保和道, 坂本直哉
第53回日本胆道学会学術集会, Sep. 2017, Oral presentation

膵充実性小病変に対する超音波内視鏡下穿刺吸引細胞診の有用性の検討　　　　　　　　　　　　　　　
杉浦諒, 桒谷将城, 平田幸司, 加藤新, 川久保和道, 坂本直哉
第115回日本消化器内視鏡学会北海道支部例会, Sep. 2017, Oral presentation

中年男性に発症し, 多発肝転移を伴った膵Solid-pseudopapillary neoplasm (SPN) の1例　　　　　　　　　　　　　　　
金谷本真, 村中徹人, 八木澤允貴, 川本泰之, 中積宏之, 結城敏志, 平田幸司, 杉浦諒, 加藤新, 川久保和道, 桒谷将城, 中村透, 岡村圭祐, 平野聡, 三橋智子, 小松嘉人, 坂本直哉
第121回日本消化器病学会北海道支部例会, Sep. 2017, Oral presentation

感染性被包化膵壊死に対する内視鏡的ネクロゼクトミーの効果　　　　　　　　　　　　　　　
加藤新, 桒谷将城, 平田幸司, 杉浦諒, 川久保和道, 坂本直哉
第115回日本消化器内視鏡学会北海道支部例会, Sep. 2017, Oral presentation

膵管内腫瘍の臨床的特徴　　　　　　　　　　　　　　　
平田幸司, 桒谷将城, 杉浦諒, 加藤新, 川久保和道, 坂本直哉, 浅野賢道, 平野聡
第115回日本消化器内視鏡学会北海道支部例会, Sep. 2017, Oral presentation

遠位悪性胆管狭窄に対する超音波内視鏡下胆管十二指腸吻合術の長期開存例の検討　　　　　　　　　　　　　　　
杉浦 諒, 桒谷 将城, 坂本 直哉
第93回日本消化器内視鏡学会総会, May 2017, Public symposium

主膵管高度狭窄に対する経乳頭的通電拡張術によるトラブルシューティング　　　　　　　　　　　　　　　
加藤新, 桒谷将城, 杉浦諒, 佐野逸紀, 川久保和道, 坂本直哉
第114回日本消化器内視鏡学会北海道支部例会, Mar. 2017, Public symposium

遠位悪性胆管狭窄に対する超音波内視鏡下胆管十二指腸吻合術と内視鏡的経乳頭胆管ステント留置術の臨床成績の比較　　　　　　　　　　　　　　　
杉浦諒, 桒谷将城, 佐野逸紀, 加藤新, 川久保和道, 坂本直哉
第114回日本消化器内視鏡学会北海道支部例会, Mar. 2017, Oral presentation

Von Hippel-Lindau病に合併した膵神経内分泌腫瘍の1例　　　　　　　　　　　　　　　
杉浦 諒, 桒谷将城, 佐野逸紀, 加藤 新, 川久保和道, 坂本直哉
第278回日本内科学会北海道地方会例会, Nov. 2016, Oral presentation

胆管プラスチックステントが逸脱後に十二指腸乳頭部口側隆起を貫通した十二指腸乳頭部癌の1例　　　　　　　　　　　　　　　
杉浦諒, 桒谷将城, 佐野逸紀, 加藤新, 川久保和道, 坂本直哉
第113回日本消化器内視鏡学会北海道支部例会, Sep. 2016, Oral presentation

奇異な経過を辿った胆管原発神経内分泌腫瘍の1例　　　　　　　　　　　　　　　
佐野逸紀, 桒谷将城, 杉浦諒, 加藤新, 川久保和道, 坂本直哉, 上野峰, 中西喜嗣, 平野聡, 岡田宏美, 三橋智子, 平田甫, 羽場真
第119回日本消化器病学会北海道支部例会, Sep. 2016, Oral presentation

IPMNの胆管穿破胆管炎に対し胆管メタリックステントが有用であった1例　　　　　　　　　　　　　　　
大川裕貴, 滝新悠之介, 鈴木和治, 杉浦 諒, 川岸直樹, 江平宣起, 岩永一郎, 上林 実
第274回日本内科学会北海道地方会例会, Jul. 2015, Oral presentation

IgG4関連胆管炎の経過中に胆管癌を発症した1例　　　　　　　　　　　　　　　
齋藤宏章, 鈴木和治, 滝新悠之介, 杉浦 諒, 川岸直樹, 江平宣起, 岩永一郎, 上林 実
第274回日本内科学会北海道地方会例会, Jul. 2015, Oral presentation

切除不能進行・再発胆道癌の予後予測因子としてアルブミン・CRP比は有用な因子となる　　　　　　　　　　　　　　　
大原正嗣, 岩永一郎, 杉浦諒, 宮本秀一, 水島健, 江平宣起, 上林実
第115回日本消化器病学会北海道支部例会, Sep. 2014, Oral presentation

治癒切除不能結腸直腸癌に対する原発巣切除と非切除群の検討　　　　　　　　　　　　　　　
宮本秀一, 岩永一郎, 大原正嗣, 杉浦諒, 水島健, 上林実
第114回日本消化器病学会 北海道支部例会, Mar. 2014, Oral presentation

軽症・中等症急性胆管炎の即日ERCP施行に関する検討　　　　　　　　　　　　　　　
江平宣起, 岩永一郎, 大原正嗣, 杉浦諒, 宮本秀一, 水島健, 上林実
第108回日本消化器内視鏡学会 北海道支部例会, Mar. 2014, Oral presentation

総胆管結石に対してEUS-Rendezvous techniqueを用いて排石した1例　　　　　　　　　　　　　　　
杉浦諒, 江平宣起, 瀧新悠之介, 大原正嗣, 宮本秀一, 水島健, 岩永一郎, 上林 実
第108回日本消化器内視鏡学会 北海道支部例会, Mar. 2014, Oral presentation

特発性孤立性上腸間膜動脈解離9例の検討　　　　　　　　　　　　　　　
杉浦諒, 太田智之, 巽亮二, 芹川真哉, 松原悠, 七尾恭子, 好崎浩司, 坂本淳, 網塚久人, 木村圭介
第112回日本消化器病学会北海道支部例会, Mar. 2013, Oral presentation

奄美大島で発症したレプトスピラ症の一例　　　　　　　　　　　　　　　
杉浦 諒, 伊東直哉
第266回日本内科学会北海道地方会例会, Feb. 2013, Oral presentation

健康食品による 肝臓ヘモジデローシスが疑われた1例　　　　　　　　　　　　　　　
杉浦 諒, 松原 悠, 巽 亮二, 芹川真哉, 七尾恭子, 好崎浩司, 坂本 淳, 網塚久人, 木村圭介, 太田智之
第111回日本消化器病学会北海道支部例会, Sep. 2012, Oral presentation

運動誘発性急性腎不全の1例　　　　　　　　　　　　　　　
杉浦諒, 八戸大輔, 太田智之, 芹川真哉, 松原悠, 七尾恭子, 好崎浩司, 坂本淳, 木村圭介, 網塚久人
第262回日本内科学会北海道地方会例会, Feb. 2012, Oral presentation