HLA class I-downregulated senescent epidermal basal cells orchestrate skin pathology in cutaneous lupus erythematosus.
Sena Yamamoto, Yuki Saito, Tsukasa Sato, Seina Nakano, Dain Kasseki, Ayaka Nagao, Norihiro Miura, Kentaro Nagaoka, Arisa Kita, Maki Miyajima, Shogo Ijima, Koji Taniguchi, Atsushi Niida, Takako S Chikenji
Arthritis & rheumatology (Hoboken, N.J.), 19 May 2025, [International Magazine]
English, Scientific journal, OBJECTIVE: To investigate the role of senescent epidermal basal cells in cutaneous lupus erythematosus (CLE) pathogenesis using skin samples from patients with CLE and a mouse model of systemic lupus erythematosus (SLE). METHODS: Cellular senescence profiling utilized datasets from the NCBI Gene Expression Omnibus database and Accelerating Medicines Partnership® (AMP®) Phase 1-Metro. Gene array data from GSE184989 (CLE: n = 68, control: n = 4), single-cell RNA sequencing data from GSE186476 (CLE: n = 7, control: n = 14), and AMP® Phase 1-Metro (SLE: n = 17) were utilized. In vitro experiments further examined the expression of p21WAF1/CIP1, type I interferon (IFN), human leukocyte antigen class I (HLA-I), and epidermal growth factor receptor (EGFR) signalling. Pharmacological clearance of senescent cells was performed using the senolytic drug fisetin in the SLE mouse model. RESULTS: p21WAF1/CIP1-high senescent epidermal basal cells in patients with CLE exhibit high type I IFN expression. These cells enhance IFN signalling in surrounding normal epidermal basal cells, leading to increased HLA-I expression. In contrast, senescent epidermal cells upregulate EGFR signalling, which downregulates HLA-I expression, allowing them to evade immune surveillance. This heterogeneity of HLA-I expression promotes CD8-positive T-mediated toxicity against normal epidermal basal cells, resulting in their apoptosis. Pharmacological clearance of senescent epidermal basal cells improved SLE-like skin lesions. CONCLUSION: Senescent cells create a microenvironment that directs cytotoxic T-cell-mediated responses against normal epidermis in CLE, contributing to disease pathology. Targeting senescent cells and their signalling pathways may offer novel therapeutic strategies for CLE and SLE skin lesions.

Characteristics of Older Adults Experiencing High Loneliness Despite Active Social Participation: A Cross-Sectional Study.
Yuri Matsuzaki, Hiroki Okada, Maki Miyajima, Rika Hirayama, Risa Takashima
Inquiry : a journal of medical care organization, provision and financing, 62, 469580251360650, 469580251360650, 2025, [International Magazine]
English, Scientific journal, Although social activity reduces loneliness levels, this relationship is not always consistent. Some older adults experience high loneliness despite active social participation. We aimed to clarify the characteristics of these individuals by focusing on their preference for solitude and satisfaction with and performance in valuable social and solitary activities. This cross-sectional survey included 3205 individuals aged ≥65 years and assessed loneliness, participation in social activities, preference for solitude, performance of valuable social and solitary activities, and depression. Participants were categorized into 3 groups based on the relationship between loneliness and social activity participation: higher social activity with a tendency toward loneliness, lower social activity without a tendency toward loneliness, and a correlated group. A one-way analysis of variance was conducted to clarify each group's characteristics. Structural equation modeling was used to explore the structure underlying the discrepancy between loneliness and social activity. Older adults experiencing high loneliness despite active social engagement preferred solitude, had low performance of valuable social and solitary activities, and reported high depression. In the high loneliness despite social activity group, a higher preference for solitude was associated with a decreased performance of social activities valuable to the individual, leading to reduced performance of solitary activities valuable to the individual. These effects contributed to increased depression, further exacerbating the discrepancy between loneliness and social activity. Some older adults may experience little to no benefit from increasing social activities. Social activities that consider older adults' solitude values could be more effective in addressing loneliness.

Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus.
Shogo Ijima, Yuki Saito, Sena Yamamoto, Kentaro Nagaoka, Taiki Iwamoto, Arisa Kita, Maki Miyajima, Tsukasa Sato, Akihiro Miyazaki, Takako S Chikenji
Immunity & ageing : I & A, 20, 1, 72, 72, 05 Dec. 2023, [International Magazine]
English, Scientific journal, Oral lichen planus is a chronic inflammatory condition that adversely affects the oral mucosa; however, its etiology remains elusive. Consequently, therapeutic interventions for oral lichen planus are limited to symptomatic management. This study provides evidence of the accumulation of senescent mesenchymal cells, CD8 + T cells, and natural killer cells in patients with oral lichen planus. We profiled the patients' tissues using the National Center for Biotechnology Information Gene Expression Omnibus database and found that senescence-related genes were upregulated in these tissues by gene set enrichment analysis. Immunohistochemical analysis showed increased senescent mesenchymal cells in the subepithelial layer of patients with oral lichen planus. Single-cell RNA-seq data retrieved from the Gene Expression Omnibus database of patients with oral lichen planus revealed that mesenchymal cells were marked by the upregulation of senescence-related genes. Cell-cell communication analysis using CellChat showed that senescent mesenchymal cells significantly influenced CD8 + T cells and natural killer cells via CXCL12-CXCR4 signaling, which is known to activate and recruit CD8 + T cells and NK cells. Finally, in vitro assays demonstrated that the secretion of senescence-associated factors from mesenchymal cells stimulated the activation of T cells and natural killer cells and promoted epithelial cell senescence and cytotoxicity. These findings suggest that the accumulation of mesenchymal cells with senescence-associated secretory phenotype may be a key driver of oral lichen planus pathogenesis.

孤立と孤独感の乖離が生じている高齢者の臨床的特徴　　　　　　　　　　　　　　　
松崎 由莉, 高島 理沙, 宮島 真貴, 岡田 宏基
日本作業療法学会抄録集, 57回, OJ, 2, (一社)日本作業療法士協会, Nov. 2023
Japanese

医療従事者における車椅子観察の視点～下肢に着目したアンケート調査～　　　　　　　　　　　　　　　
浮田徳樹,相原彩香,宮島真貴
車椅子シーティング研究, 8, 1, 2, 10, Nov. 2023, [Peer-reviewed]
Scientific journal

The Effects of Cognitive Rehabilitation Targeting Frontal Lobe Executive Function in Mild Cognitive Impairment
Yuri Matsuzaki, Hidetoshi Omiya, Takayuki Hisakura, Hiroki Tanii, Maki Miyajima
Asian Journal of Occupational Therapy, 19, 1, 205, 212, Japanese Association of Occupational Therapists, 2023
Scientific journal

Fisetin reduces the senescent tubular epithelial cell burden and also inhibits proliferative fibroblasts in murine lupus nephritis
Shogo Ijima, Yuki Saito, Kentaro Nagaoka, Sena Yamamoto, Tsukasa Sato, Norihiro Miura, Maki Miyajima, Takako S. Chikenji
Frontiers in Immunology, 13, 960601, 960601, Oct. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by the involvement of multiple organs. Lupus nephritis (LN) is a major risk factor for overall morbidity and mortality in SLE patients. Hence, designing effective drugs is pivotal for treating individuals with LN. Fisetin plays a senolytic role by specifically eliminating senescent cells, inhibiting cell proliferation, and exerting anti-inflammatory, anti-oxidant, and anti-tumorigenic effects. However, limited research has been conducted on the utility and therapeutic mechanisms of fisetin in chronic inflammation. Similarly, whether the effects of fisetin depend on cell type remains unclear. In this study, we found that LN-prone MRL/lpr mice demonstrated accumulation of Ki-67-positive myofibroblasts and p15INK4B-positive senescent tubular epithelial cells (TECs) that highly expressed transforming growth factor β (TGF-β). TGF-β stimulation induced senescence of NRK-52E renal TECs and proliferation of NRK-49F renal fibroblasts, suggesting that TGF-β promotes senescence and proliferation in a cell type-dependent manner, which is inhibited by fisetin treatment in vitro. Furthermore, fisetin treatment in vivo reduced the number of senescent TECs and myofibroblasts, which attenuated kidney fibrosis, reduced senescence-associated secretory phenotype (SASP) expression, and increased TEC proliferation. These data suggest that the effects of fisetin vary depending on the cell type and may have therapeutic effects in complex and diverse LN pathologies.

Risk level-specific hazardous drinking factors of alcohol use disorders in Japanese university students　　　　　　　　　　　　　　　
Miyajima Maki, Miyata Tomoki, Murakami Yui, Yotsumoto Kayano, Ukita Atsuki, MorimotoTakafumi, Kobayashi Masayoshi, Tanaka Hiroyuki, Yamada Sumie, Matsusaki Yuri, Inoue Takao
Journal of Substance Use, Oct. 2022, [Peer-reviewed], [Lead author]
Scientific journal

A Pilot Study of Illness Management and Recovery in Patients Acutely Admitted to a Psychiatric Ward
Maki Miyajima, Yukie Hatakeyama, Kazumasa Ichiki, Yuri Matsuzaki, Hazuki Niyama, Hidetoshi Omiya
Journal of Psychosocial Rehabilitation and Mental Health, Springer Science and Business Media LLC, 28 Jul. 2022, [Peer-reviewed], [Lead author]
Scientific journal

Intrathecal Injection of Mesenchymal Stromal Cell Cultured on 3D Fiber Ameliorates Multiple Organ Damage in Murine Lupus
Yuki Saito, Maki Miyajima, Sena Yamamoto, Norihiro Miura, Tsukasa Sato, Arisa Kita, Shogo Ijima, Mineko Fujimiya, Takako S Chikenji
Stem Cells Translational Medicine, Oxford University Press (OUP), 25 Apr. 2022, [Peer-reviewed]
Scientific journal, Abstract

Up to 60% of patients with systemic lupus erythematosus (SLE) experience autonomic symptom. Sympathetic nervous system damage can cause dysfunction of the bone marrow that activates inflammatory cells, potentially causing multiple organ damage. We hypothesized that sympathetic nervous system damage would induce bone marrow dysfunction with multiple organ damage in SLE, and that multiple organ damage could be improved by therapy targeting the nervous system. Here, we showed that damage to autonomic nerves and Schwann cells occurred in the bone marrow and central nervous system of SLE model mice. A neurotoxic drug increased mortality and induced severe neuropathy and multiple organ damage, while a neuroprotective drug prevented multiple organ damage. The administration of bone marrow-derived mesenchymal stromal cells (BMSCs) cultured on a 3-dimensional fiber scaffold improved bone marrow neuropathy, skin lesions, kidney function, and mortality. Our results reveal that bone marrow neuropathy influence multiple organ damage associated with SLE, and improvement of bone marrow neuropathy by intrathecal injection of BMSC may be a target for SLE multiple-organ damage.

Altered regulation of mesenchymal cell senescence in adipose tissue promotes pathological changes associated with diabetic wound healing
Arisa Kita, Yuki Saito, Norihiro Miura, Maki Miyajima, Sena Yamamoto, Tsukasa Sato, Takatoshi Yotsuyanagi, Mineko Fujimiya, Takako S. Chikenji
Communications Biology, 5, 1, 310, 310, Springer Science and Business Media LLC, 05 Apr. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Abstract

Pathologic diabetic wound healing is caused by sequential and progressive deterioration of hemostasis, inflammation, proliferation, and resolution/remodeling. Cellular senescence promotes wound healing; however, diabetic wounds exhibit low levels of senescent factors and accumulate senescent cells, which impair the healing process. Here we show that the number of p15^INK4B + PDGFRα + senescent mesenchymal cells in adipose tissue increases transiently during early phases of wound healing in both non-diabetic mice and humans. Transplantation of adipose tissue from diabetic mice into non-diabetic mice results in impaired wound healing and an altered cellular senescence–associated secretory phenotype (SASP), suggesting that insufficient induction of adipose tissue senescence after injury is a pathological mechanism of diabetic wound healing. These results provide insight into how regulation of senescence in adipose tissue contributes to wound healing and could constitute a basis for developing therapeutic treatment for wound healing impairment in diabetes.

Accumulation of Senescent Neural Cells in Murine Lupus With Depression-Like Behavior
Yuki Saito, Maki Miyajima, Sena Yamamoto, Tsukasa Sato, Norihiro Miura, Mineko Fujimiya, Takako S. Chikenji
Frontiers in Immunology, 12, 692321, 692321, 03 Nov. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, Neuropsychiatric manifestations targeting the central, peripheral, and autonomic nervous system are common in systemic lupus erythematosus (SLE); collectively, these symptoms are termed neuropsychiatric SLE (NPSLE). Among a wide variety of neuropsychiatric symptoms, depression is observed in about 24-39% of SLE patients. Several cytokines and chemokines have been identified as biomarkers or therapeutic targets of NPSLE; in particular, the levels of type 1 interferons, TNFs, and IL-6 are elevated in SLE patient's cerebrospinal fluid (CSF), and these factors contribute to the pathology of depression. Here, we show that senescent neural cells accumulate in the hippocampal cornu ammonis 3 (CA3) region in MRL/lpr SLE model mice with depressive behavior. Furthermore, oral administration of fisetin, a senolytic drug, reduced the number of senescent neural cells and reduced depressive behavior in the MRL/lpr mice. In addition, transcription of several senescence and senescence-associated secretory phenotype (SASP) factors in the hippocampal region also decreased after fisetin treatment in the MRL/lpr mice. These results indicate that the accumulation of senescent neural cells in the hippocampus plays a role in NPSLE pathogenesis, and therapies targeting senescent cells may represent a candidate approach to treat NPSLE.

前頭葉/実行機能プログラム(FEP)を用いて認知機能の改善がみられた軽度認知障害(MCI)の事例　　　　　　　　　　　　　　　
松崎 由莉, 宮島 真貴, 大宮 秀淑
日本作業療法学会抄録集, 53回, PJ, 1F05, (一社)日本作業療法士協会, Sep. 2019
Japanese

前頭葉/実行機能プログラム（FEP)を用いて認知機能の改善がみられたMCIの一例　　　　　　　　　　　　　　　
松㟢由莉, 宮島真貴, 大宮秀淑
日本認知症予防学会誌, 9, 1, 17, 21, (一社)日本認知症予防学会, Sep. 2019, [Peer-reviewed]
Japanese, Scientific journal

The effect of Cognitive Remediation Therapy (CRT) on mild cognitive impairment (MCI)-Case report by Frontal/Executive Program (FEP)-
大宮秀淑, 松㟢由莉, 宮島真貴
札幌学院大学心理学紀要第2巻第１号, 2, 1, 1, 12, 札幌学院大学総合研究所 = Research Institute of Sapporo Gakuin University, 2019, [Peer-reviewed], [Last author]
Japanese, Research institution, The purpose of this study is to examine whether or not an intervention using Frontal / Executive Program （FEP） is effective to improve cognitive functions of people with MCI. Subject was a woman in her 80s who was living alone at the time of the intervention. With regard to her cognitive functions, she was aware of problems with memory, such as being not good at remembering. Total of 22 sessions of FEP were performed; two sessions a week, one on one, each session lasting about an hour. She was assessed to have MCI using MoCA-J. To obtain an objective evaluation before and after the intervention, the Brief Assessment of Cognition in Schizophrenia- Japanese version （BACS-J）, Wisconsin Card Sorting Test （WCST） and Continuous Performance Test （CPT） were performed. As a result, the subject's verbal fluency and digit sequencing performances before the intervention were notably low in BACS-J, but after the intervention, composite score, verbal memory and the Tower of London showed significant improvement. It was shown that FEP improves the results of cognitive function tests, such as reduction of errors in WCST and CPT, suggesting the applicability of FEP to people with MCI. Compared with other mental illnesses, the result of this study was characteristic because the subject's verbal fluency did not show enough improvement. In the future, it will be necessary to conduct further studies with more number of cases and to examine the specificity of MCI's cognitive functions.Article

Therapeutic responses to a frontal/executive programme in autism spectrum disorder: Comparison with schizophrenia.
Miyajima M, Omiya H, Yamashita K, Yambe K, Matsui M, Denda K
Hong Kong journal of occupational therapy : HKJOT, 31, 2, 69, 75, Dec. 2018, [Peer-reviewed]
English, Scientific journal

認知機能改善療法の紹介 二疾患を対象にした前頭葉/実行機能プログラムの有効性の検討　　　　　　　　　　　　　　　
宮島 真貴, 大宮 秀淑, 山下 聖子, 山家 研司, 傳田 健三
日本作業療法学会抄録集, 51回, OH, 3, (一社)日本作業療法士協会, Sep. 2017
Japanese

前頭葉・実行機能プログラム(Frontal/Executive Program;FEP)日本語版の紹介
大宮 秀淑, 傳田 健三, 山家 研司, 松本 出, 宮島 真貴, 松井 三枝
精神医学, 59, 3, 275, 281, (株)医学書院, Mar. 2017, [Peer-reviewed]
Japanese

自閉スペクトラム症に対する認知機能改善療法の効果研究 Frontal/Executive Program(FEP)の有効性　　　　　　　　　　　　　　　
宮島 真貴, 大宮 秀淑, 山下 聖子, 山家 研司, 傳田 健三
北海道児童青年精神保健学会会誌, 30, 30, 30, 北海道児童青年精神保健学会事務局, Nov. 2016
Japanese

Pilot study of the effects of cognitive remediation therapy using the frontal/executive program for treating chronic schizophrenia
Hidetoshi Omiya, Kiyoko Yamashita, Tomoki Miyata, Yukie Hatakeyama, Maki Miyajima, Kenji Yambe, Izuru Matsumoto, Mie Matsui, Atsuhito Toyomaki, Kenzo Denda
Open Psychology Journal, 9, 121, 128, Bentham Science Publishers B.V., 01 Oct. 2016, [Peer-reviewed]
English, Scientific journal

The effects of cognitive remediation therapy using the frontal/executive program for autism spectrum disorder
Maki Miyajima, Hidetoshi Omiya, Kiyoko Yamashita, Tomoki Miyata, Kenji Yambe, Mie Matsui, Kenzo Denda
INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE, 51, 3, 223, 235, Apr. 2016, [Peer-reviewed]
English, Scientific journal

統合失調と自閉スペクトラム症における認知機能障害の比較　　　　　　　　　　　　　　　
宮島 真貴, 大宮 秀淑, 山下 聖子, 山家 研司, 傳田 健三
最新精神医学, 21, 2, 145, 149, (株)世論時報社, Mar. 2016
Japanese

自閉スペクトラム症に対する前頭葉/実行機能プログラム(FEP)を用いた認知機能改善療法の効果研究
宮島 真貴, 大宮 秀淑, 山家 研司, 松井 三枝, 傳田 健三
作業療法, 35, 1, 22, 31, (一社)日本作業療法士協会, Feb. 2016
Japanese

前頭葉/実行機能プログラムが有効であった成人期自閉スペクトラム症の1例　　　　　　　　　　　　　　　
宮島 真貴, 山下 聖子, 松井 三枝, 山家 研司, 傳田 健三
日本作業療法学会抄録集, 20, 2, 169, 175, (一社)日本作業療法士協会, Jun. 2015, [Peer-reviewed]
English

東日本大震災後の高校生における心理状態の変化 心理的支援による1年後の変化から
井上 貴雄, 船越 俊一, 大宮 秀淑, 宮島 真貴, 傳田 健三
こころの健康, 30, 1, 73, 73, 日本精神衛生学会, Jun. 2015
Japanese

統合失調症と広汎性発達障害の認知機能の比較　　　　　　　　　　　　　　　
宮島 真貴, 大宮 秀淑, 宮田 友樹, 山下 聖子, 山家 研司, 傳田 健三
こころの健康, 30, 1, 72, 72, 日本精神衛生学会, Jun. 2015
Japanese

前頭葉/実行機能プログラムが有効であった成人期自閉スペクトラム症の1例　　　　　　　　　　　　　　　
宮島 真貴, 大宮 秀淑, 山下 聖子, 松井 三枝, 山家 研司, 傳田 健三
最新精神医学, 20, 2, 169, 175, (株)世論時報社, Mar. 2015
Japanese

自然災害の諸要因が高校生の心理状態に及ぼす影響の検討 東日本大震災から1年4ヵ月後の高校生実態調査　　　　　　　　　　　　　　　
船越 俊一, 大野 高志, 小高 晃, 奥山 純子, 本多 奈美, 井上 貴雄, 佐藤 祐基, 宮島 真貴, 富田 博秋, 傳田 健三, 松岡 洋夫
精神神経学雑誌, 116, 7, 541, 554, (公社)日本精神神経学会, Jul. 2014
Japanese

[Factors associated with the psychological impact of the Great East Japan earthquake on high school students 1 year and 4 months after the disaster].
Funakoshi S, Ohno T, Kodaka A, Okuyama J, Honda N, Inoue T, Sato Y, Miyajima M, Tomita H, Denda K, Matsuoka H
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 116, 7, 541, 554, 2014, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, The purpose of this study was to investigate factors associated with the psychological impact of the Great East Japan Earthquake on high school students 1 year and 4 months after the disaster, and clarify support needs of the students. In the outreach program for students of three high schools in coastal areas of southern Miyagi Prefecture, Japan, 1,973 students were surveyed after obtaining informed consent for participation. Questionnaires included: the Quick Inventory of Depressive Symptomatology (QIDS-J), Self-rating Anxiety Scale (SAS), Impact of Event Scale-revised (IES-R), and Connor-Davidson Resilience Scale (CD-RISC10). All scores were compared using SPSS 20.0 J between school grades, locations of the schools, and extent of damage due to the Great East Japan Earthquake. Our analysis showed a significant positive correlation between school grades and the level of anxiety. PTSR scores, but not anxiety nor depressive scores, of students whose lives have suffered extensive damage were significantly higher than those of students who have not. Students of high schools which have suffered extensive damage and use temporary buildings showed significantly higher levels of depression and anxiety, and significantly lower resilience, compared to students of high schools which were not damaged. Although previous findings demonstrated that younger children have a higher risk of being influenced by disasters, symptoms related to PTSR and depression were found frequently in the high school students as well. Among the high school students, our analysis showed a positive correlation between the level of anxiety and school grades, probably because the disaster has affected an influential and pivotal point in their lives.

小・中・高校生における抑うつ症状、躁症状および自閉傾向
井上 貴雄, 佐藤 祐基, 宮島 真貴, 傳田 健三
児童青年精神医学とその近接領域, 54, 5, 571, 587, (一社)日本児童青年精神医学会, Nov. 2013
Japanese

認知リハビリテーションをきっかけに福祉的就労につながった一症例 NEARによる実践　　　　　　　　　　　　　　　
加藤 ちえ, 井上 貴雄, 宮島 真貴, 豊巻 敦人, 橋本 直樹
日本作業療法学会抄録集, 47回, O199, O199, (一社)日本作業療法士協会, Jun. 2013
Japanese

統合失調症患者に対する認知矯正療法の効果 神経認知機能とThe Schizophrenia Quality of Life Scale日本語版(JSQLS)の変化から　　　　　　　　　　　　　　　
井上 貴雄, 加藤 ちえ, 宮島 真貴, 豊巻 敦人, 橋本 直樹
日本作業療法学会抄録集, 47回, O202, O202, (一社)日本作業療法士協会, Jun. 2013
Japanese

Discrepancy of neural response between exogenous and endogenous task switching: an event-related potentials study
Maki Miyajima, Atsuhito Toyomaki, Naoki Hashimoto, Ichiro Kusumi, Harumitsu Murohashi, Tsukasa Koyama
NEUROREPORT, 23, 11, 642, 646, Aug. 2012, [Peer-reviewed]
English, Scientific journal

小・中・高校生の自閉傾向に関する実態調査 自閉症スペクトラム指数日本語版(AQ-J)を用いて　　　　　　　　　　　　　　　
宮島 真貴, 井上 貴雄, 佐藤 祐基, 久住 一郎, 傳田 健三
最新精神医学, 17, 4, 364, 370, (株)世論時報社, Jul. 2012
Japanese

Comparison of neural responses between exogenous and endogenous rule shifting in cued switching task; an ERPs study.
Maki Miyajima, Atuhito Toyomaki, Ichiro Kusumi, Tsukasa Koyama
Proceedings of the 34th Annual Meeting of the Cognitive Science Society, CogSci 2012, Sapporo, Japan, August 1-4, 2012, cognitivesciencesociety.org, 2012, [Peer-reviewed]

気分障害における作業記憶課題遂行時の事象関連電位・事象関連同期の異常　　　　　　　　　　　　　　　
豊巻 敦人, 清水 祐輔, 橋本 直樹, 宮島 真貴, 久住 一郎, 小山 司
臨床神経生理学, 39, 5, 486, 486, (一社)日本臨床神経生理学会, Oct. 2011
Japanese

【広汎性発達障害とcomorbidity】 広汎性発達障害と気分障害
傳田 健三, 佐藤 祐基, 井上 貴雄, 宮島 真貴
児童青年精神医学とその近接領域, 52, 2, 143, 150, (一社)日本児童青年精神医学会, Apr. 2011
Japanese

The Effects of Cognitive Rehabilitation Targeting Frontal Lobe Executive Function in Mild Cognitive Impairment
Yuri Matsuzaki, Hidetoshi Omiya, Maki Miyajima, The Journal of Neuropsychiatry and Clinical Neurosciences, 33, 3, 233, 257, Jul. 2021
American Psychiatric Association Publishing

前頭葉・実行機能プログラム(Frontal/Executive Program;FEP)日本語版の紹介
大宮 秀淑, 傳田 健三, 山家 研司, 松本 出, 宮島 真貴, 松井 三枝, 精神医学, 59, 3, 275, 281, Mar. 2017
(株)医学書院, Japanese

統合失調症患者に対する認知リハビリテーション(ブレインステーション)についての報告 北海道大学病院精神科神経科の取り組み　　　　　　　　　　　　　　　
井上 貴雄, 橋本 直樹, 豊巻 敦人, 加藤 ちえ, 岸 展江, 國田 幸治, 中谷 紫乃, 川島 るい, 佐藤 昭宏, 成田 学, 松尾 萌, 宮島 真貴, 清水 祐輔, 久住 一郎, 精神神経学雑誌, 115, 1, 101, 101, Jan. 2013
(公社)日本精神神経学会, Japanese

最新作業療法学講座 精神障害作業療法学　　　　　　　　　　　　　　　
早坂 友成
医歯薬出版, Feb. 2025, [Joint work]

精神科リハビリテーション評価法ハンドブック　　　　　　　　　　　　　　　
早坂友成, 編著, 岩根達郎, 編著, 森元隆文
中外医学社, Apr. 2023, 9784498229464, [Joint work]

精神科実臨床における認知機能リハビリテーションの実践
久住, 一郎
中外医学社, Apr. 2023, 9784498229426, vi, 185p, Japanese, [Joint work]

運動による間葉系前駆細胞の老化関連遺伝シグネチャーは糖尿病骨格筋で減弱する　　　　　　　　　　　　　　　
葛石大入, 齋藤悠城, 宮島真貴, 佐藤吏紗, 山本瀬菜, 千見寺貴子
第46回日本炎症・再生医学会, Jul. 2025

うつ病患者およびモデルマウスにおける細胞老化関連遺伝子発現の変化　　　　　　　　　　　　　　　
長尾彩花, 齋藤悠城, 佐藤吏紗, 山本瀬菜, 葛石大入, 宮島真貴, 千見寺貴子
第46回日本炎症・再生医学会, Jul. 2025

関節リウマチにおける老化細胞の同定と老化細胞除去による滑膜炎の抑制　　　　　　　　　　　　　　　
葛石大入, 松本陽太, 宮島真貴, 佐藤吏紗, 山本瀬菜, 齋藤悠城, 千見寺貴子
第46回日本炎症・再生医学会, Jul. 2025

自閉スペクトラム症モデルマウスにおける細胞老化とシナプス刈り込み異常　　　　　　　　　　　　　　　
宮島真貴, 齋藤 悠城, 佐藤 吏紗, 山本 瀬奈, 外丸 詩野, 石津 明洋, 千見寺 貴子
第１１回日本小児診療多職種学会, 08 Mar. 2025, Oral presentation
08 Mar. 2025 - 09 Mar. 2025

老化細胞の免疫回避機構が関わる皮膚エリテマトーデス病態　　　　　　　　　　　　　　　
山本 瀬菜, 齋藤 悠城, 中野 世那, 佐藤 吏紗, 三浦 倫寛, 長岡 賢太郎, 北 愛里紗, 宮島 真貴, 井嶋 翔吾, 谷口 浩二, 新井田 厚司, 千見寺 貴子
日本薬学会第145年会, Mar. 2025

Preference for Solitude and Satisfaction with Occupation in Older Adults with Discrepancies Between Loneliness and Social Participation Levels　　　　　　　　　　　　　　　
Yuri Matsuzaki, Maki Miyajima, Hiroki Okada, Rika Hirayama, Risa Takashima
The 8th Asia Pacific Occupational Therapy Congress 2024, 08 Nov. 2024, English
06 Nov. 2024 - 09 Nov. 2024

A Study on the Perceptions of Occupational Therapists in Japanese School Education and Interventions in Educational Settings　　　　　　　　　　　　　　　
Riko Mioka, Karen Kida, Reika Takase, Maki Miyajima
The 8th Asia Pacific Occupational Therapy Congress 2024, 06 Nov. 2024, English
06 Nov. 2024 - 09 Nov. 2024

老化細胞の免疫回避機構に着眼したエリテマトーデスの皮膚病態の解明　　　　　　　　　　　　　　　
山本 瀬菜, 齋藤 悠城, 中野 世那, 佐藤 吏紗, 三浦 倫寛, 長岡 賢太郎, 北愛里紗, 宮島 真貴, 井嶋 翔吾, 谷口 浩二, 新井田 厚司, 千見寺 貴子
第97回日本生化学会大会, Nov. 2024

Senescent neural progenitor cells increased neurite outgrowth in mouse model of Maki Miyajima1 , Miyu Yokouchi1 , autism spectrum disorders　　　　　　　　　　　　　　　
Maki Miyajima, Miyu Yokouchi, Yuki Saito, Tsukasa Sato, Sena Yamamoto、Utano Tomaru, Akihiro Ishizu, Takako S Chikenji
Cytokines 2024 & KAI 2024, Oct. 2024, English
20 Oct. 2024 - 23 Oct. 2024

Cellular senescence in the hippocampus regulates resilience to chronic stress by secreting neurogenic/protective factors　　　　　　　　　　　　　　　
Tsukasa Sato, Yuki Saito, Sena Yamamoto, Norihiro Miura, Maki Miyajima, Takako S. Chikenji
Cytokines 2024＆ KAI 2024, Oct. 2024, English
20 Oct. 2024 - 23 Oct. 2024

HLA class I-downregulated senescent epidermal basal cells orchestrate skin pathology in systemic lupus erythematosus　　　　　　　　　　　　　　　
Sena Yamamoto,Yuki Saito, Seina Nakano,Tsukasa Sato,Norihiro Miura,Kentaro Nagaoka,Arisa Kita, Maki Miyajima,Shogo Ijima,Koji Taniguchi,Atsushi Niida,Takako S. Chikenji
Cytokines 2024＆ KAI 2024, Oct. 2024, English, Oral presentation
20 Oct. 2024 - 23 Oct. 2024

細胞老化随伴分泌現象は全身性エリテマトーデスにおける表皮細胞の免疫原性を高める　　　　　　　　　　　　　　　
山本 瀬菜, 齋藤 悠城, 井嶋 翔吾, 北 愛里紗, 三浦 倫寛, 佐藤 吏紗, 宮島 真貴, 千見寺 貴子
第45回日本炎症・再生医学会, Jul. 2024

Exercise-induced senescence-like gene signature in fibro/adipogenic progenitors is impaired in diabetes muscle　　　　　　　　　　　　　　　
Y Saito, N Miura, S Yamamoto, T Sato, K Nagaoka, T Iwamoto, M Miyajima, A Kita, T. S, Chikenji
Cell Bio 23, Dec. 2023, Poster presentation
02 Dec. 2023 - 06 Dec. 2023

Cellular senescence in epidermal stem cells as a potential driver of lupus erythematosus skin lesions　　　　　　　　　　　　　　　
S Yamamoto, Y Saito, T Sato, N Miura, K, Nagaoka,T, Iwamoto, M Miyajima, A Kita,T, S, Chikenji
Cell Bio 23, Dec. 2023, Poster presentation

Involvement of cellular senescence in the pathogenesis of lupus nephritis in mice　　　　　　　　　　　　　　　
K Nagaoka, Y Saito, S Ijima, S, Yamamoto,T Sato, N Miura,T Iwamoto, M, Miyajima,T.S, Chikenji
Cell bio 23, Dec. 2023, Poster presentation

孤立と孤独感の乖離が生じている高齢者の臨床的特徴　　　　　　　　　　　　　　　
松㟢由莉, 髙島理沙, 宮島真貴, 岡田宏基
第57回日本作業療法学会, 11 Nov. 2023

Social Activities Impacting Loneliness among Older Adults in Japan　　　　　　　　　　　　　　　
Yuri Matsuzaki, Risa Takashima, Hiroki Okada, Maki Miyajima
6th FHS International Conference, 20 Oct. 2023

個別の前頭葉・実行機能プログラムにより認知機能が改善した医療観察法入院中の統合失調症の一例　　　　　　　　　　　　　　　
國田幸治, 小野智矢, 大塚敬治, 高信径介, 宮島真貴, 賀古勇輝
第19回日本司法精神医学会大会, 09 Sep. 2023

自閉スペクトラム症モデルマウスにおける神経前駆細胞の細胞老化　　　　　　　　　　　　　　　
宮島 真貴, 齋藤 悠城, 佐藤 吏紗, 山本 瀬菜, 三浦 倫寛, 千見寺貴子
第44回日本炎症再生医学会, 12 Jul. 2023, Poster presentation

全身性エリテマトーデス皮膚炎における老化細胞の役割とシングルセル解析による病態解明　　　　　　　　　　　　　　　
山本 瀬菜, 齋藤 悠城, 井嶋 翔吾, 北 愛里紗, 三浦 倫寛, 佐藤 吏紗, 宮島 真貴, 千見寺貴子
第44回日本炎症再生医学会, 12 Jul. 2023, Poster presentation

滑膜線維芽細胞の細胞老化は関節リウマチにおける炎症性組織プライミング誘導に関与する　　　　　　　　　　　　　　　
齋藤 悠城, 岩本 大輝, 山本 瀬菜, 宮島 真貴, 村橋 靖崇, 寺本 篤史, 射場 浩介, 山下 敏彦, 千見寺貴子
第44回日本炎症再生医学会, 12 Jul. 2023, Poster presentation

老化細胞除去薬フィセチンが尿細管細胞の細胞老化と腎再生に与える影響　　　　　　　　　　　　　　　
長岡 賢太郎, 齋藤 悠城, 井嶋 翔吾, 山本 瀬菜, 佐藤 吏紗, 三浦 倫寛, 岩本 大輝, 宮島 真貴, 千見寺 貴子
第22回日本再生医療学会, 23 Mar. 2023, Poster presentation

全身性エリテマトーデスの皮膚病態と再生に関わる老化表皮幹細胞　　　　　　　　　　　　　　　
山本 瀬菜, 齋藤 悠城, 井嶋 翔吾, 北 愛里紗, 三浦 倫寛, 佐藤 吏紗, 宮島 真貴, 千見寺 貴子
第22回日本再生医療学会, 23 Mar. 2023, Oral presentation

海馬における細胞老化は神経新生を促進して慢性ストレス誘発性うつ様症状に抵抗する　　　　　　　　　　　　　　　
佐藤 吏紗, 齋藤 悠城, 山本 瀬菜, 三浦 倫寛, 岩本 大輝, 長岡 賢太郎, 宮島 真貴, 千見寺 貴子
第22回日本再生医療学会, 23 Mar. 2023, Oral presentation

A PILOT STUDY OF ILLNESS MANAGEMENT AND RECOVERY IN PATIENTS ACUTELY ADMITTED TO A PSYCHIATRIC WARD　　　　　　　　　　　　　　　
Yuri Matsusaki, Hidetoshi Omoiya, Yukie Hatakeyama, Kazumasa Ichiki, Hazuki Niyama, Maki Miyajima
The 22nd WPA World Congress of Psychiatry, 03 Aug. 2022, Poster presentation
03 Aug. 2022 - 06 Aug. 2022

The effects of cognitive rehabilitation targeting frontal lobe executive function in mild cognitive impairment　　　　　　　　　　　　　　　
Yuri Matsuzaki, Hidetoshi Omiya, Maki Miyajima
The 22nd WPA World Congress of Psychiatry, 03 Aug. 2022, English, Poster presentation
03 Aug. 2022 - 06 Aug. 2022

全身性エリテマトーデスモデルマウスにおける骨髄神経障害は多臓器障害を悪化させる　　　　　　　　　　　　　　　
齋藤 悠城, 宮島 真貴, 山本 瀬菜, 三浦 倫寛, 佐藤 吏紗, 北 愛里紗, 井嶋 翔吾, 藤宮 峯子, 千見寺貴子
第43回日本炎症再生学会, 06 Jul. 2022
06 Jul. 2022 - 07 Jul. 2022

フィセチンによる老化細胞除去はMRL/lprマウスのエリテマトーデス様皮膚病変を改善する　　　　　　　　　　　　　　　
山本 瀬菜, 齋藤 悠城, 井嶋 翔吾, 北 愛里紗, 三浦 倫寛, 佐藤 吏紗, 宮島 真貴, 千見寺貴子
第43回日本炎症再生学会, 06 Jul. 2022
06 Jul. 2022 - 07 Jul. 2022

Altered regulation of senescence-associated secretory phenotype in hippocampus modulates resilience to chronic mild psychiatric stress　　　　　　　　　　　　　　　
Tsukasa Sato, Yuki Saito, Maki Miyajima, Sena Yamamoto, Norihiro Miura, Mineko Fujimiya, Takako S Chikenji
The 6th International Cell Senescence Association Conference, 13 Dec. 2021, Poster presentation
12 Dec. 2021 - 15 Dec. 2021

Fisetin improved depressive behavior in murine lupus by decreasing senescent neural cell　　　　　　　　　　　　　　　
Yuki Saito, Maki Miyajima, Sena Yamamoto, Tsukasa Sato, Norihiro Miura, Mineko Fujimiya, Takako S Chikenji
The 6th International Cell Senescence Association Conference, 13 Dec. 2021, Oral presentation
12 Dec. 2021 - 15 Dec. 2021

Lower-expression of Cdkn2a is associated with dysregulation of fibro-adipogenic progenitors results in skeletal muscle atrophy and degeneration in diabetic mice　　　　　　　　　　　　　　　
Norihiro Miura, Yuki Saito, Arisa Kita, Maki Miyajima, Tsukasa Sato, Sena Yamamoto, Mineko Fujimiya, Takako S Chikenji
The 6th International Cell Senescence Association Conference, 13 Dec. 2021, Poster presentation
12 Dec. 2021 - 15 Dec. 2021

Senolysis by fisetin ameliorates lupus erythematosus-like skin lesions in MRL/lpr mice　　　　　　　　　　　　　　　
Sena Yamamoto, Yuki Saito, Shogo Ijima, Arisa Kita, Norihiro Miura, Tsukasa Sato, Maki Miyajima, Mineko Fujimiya, Takako S Chikenji
The 6th International Cell Senescence Association Conference, 13 Dec. 2021, Poster presentation
12 Dec. 2021 - 15 Dec. 2021

Dual role of TGF-β1 in cellular senescence of tubular cells and hyper-proliferation of fibroblasts to aggravate lupus nephritis　　　　　　　　　　　　　　　
Shogo Ijima, Yuki Saito, Maki Miyajima, Mineko Fujimiya, Takako S. Chikenji
The 6th International Cell Senescence Association Conference, 13 Dec. 2021, Poster presentation
12 Dec. 2021 - 15 Dec. 2021

Accumulation of senescent neurons in mice model of autism spectrum disorder with abnormal synaptic pruning　　　　　　　　　　　　　　　
Maki Miyajima, Yuki Saito, Tsukasa Sato, Norihiro Miura, Sena Yamamoto, Mineko Fujimiya, Takako S. Chikenji
The 6th International Cell Senescence Association Conference, 13 Dec. 2021, Poster presentation
12 Dec. 2021 - 15 Dec. 2021

前頭葉/実行機能プログラム（FEP)を用いて認知機能の改善がみられた軽度認知障害（MCI)の事例　　　　　　　　　　　　　　　
松㟢由莉、宮島真貴、大宮秀淑
第53回日本作業療法学会, Sep. 2019, Poster presentation
06 Sep. 2019 - 08 Sep. 2019

軽度認知障害に対する認知機能改善療法の有効性の検討　　　　　　　　　　　　　　　
松㟢由莉、宮島真貴、大宮秀淑
第8回日本認知症予防学会, Sep. 2018, Poster presentation
22 Sep. 2018 - 24 Sep. 2018

認知機能改善療法の紹介 二疾患を対象にした前頭葉/実行機能プログラムの有効性の検討　　　　　　　　　　　　　　　
宮島 真貴, 大宮 秀淑, 山下 聖子, 山家 研司, 傳田 健三
日本作業療法学会抄録集, Sep. 2017, Japanese

自閉スペクトラム症に対する認知機能改善療法の効果研究 Frontal/Executive Program(FEP)の有効性　　　　　　　　　　　　　　　
宮島 真貴, 大宮 秀淑, 山下 聖子, 山家 研司, 傳田 健三
北海道児童青年精神保健学会会誌, Nov. 2016, Japanese

自閉スペクトラム症に対するFrontal/Executive Programが有効であった例と、変化が認められなかった症例の比較　　　　　　　　　　　　　　　
宮島 真貴, 山下 聖子, 山家 研司, 松井 三枝, 傳田 健三
北海道児童青年精神保健学会会誌, Dec. 2015, Japanese

依存症に対するデイケアの取り組み 解毒期を過ぎた患者を対象に　　　　　　　　　　　　　　　
宮島 真貴, 工藤 望, 蓑島 千晶, 山下 聖子
北海道作業療法, Sep. 2015, Japanese

前頭葉/実行機能プログラムが有効であった成人期自閉スペクトラム症の1例　　　　　　　　　　　　　　　
宮島 真貴, 山下 聖子, 松井 三枝, 山家 研司, 傳田 健三
日本作業療法学会抄録集, Jun. 2015, Japanese

統合失調症患者における作業記憶障害の神経基盤と介入への示唆　　　　　　　　　　　　　　　
宮島 真貴, 豊巻 敦人, 宮崎 茜, 久住 一郎
日本作業療法学会抄録集, Jun. 2013, Japanese

統合失調症患者に対する認知矯正療法の効果 神経認知機能とThe Schizophrenia Quality of Life Scale日本語版(JSQLS)の変化から　　　　　　　　　　　　　　　
井上 貴雄, 加藤 ちえ, 宮島 真貴, 豊巻 敦人, 橋本 直樹
日本作業療法学会抄録集, Jun. 2013, Japanese

認知リハビリテーションをきっかけに福祉的就労につながった一症例 NEARによる実践　　　　　　　　　　　　　　　
加藤 ちえ, 井上 貴雄, 宮島 真貴, 豊巻 敦人, 橋本 直樹
日本作業療法学会抄録集, Jun. 2013, Japanese

統合失調症におけるrule shiftingの処理過程の解明 事象関連電位による検討　　　　　　　　　　　　　　　
宮島 真貴, 豊巻 敦人, 久住 一郎
北海道作業療法, Sep. 2012, Japanese

外来作業療法に通う統合失調症患者に対する認知矯正療法の治療効果について　　　　　　　　　　　　　　　
宮島 真貴, 橋本 直樹, 豊巻 敦人, 久住 一郎, 小山 司
日本作業療法学会抄録集, Jun. 2012, Japanese