伊　敏 (イ　ミン)

医学研究院　病理系部門　微生物学免疫学分野助教
Last Updated :2025/06/14

■研究者基本情報

学位

  • 医学博士, 北海道大学
  • 医科学修士, 筑波大学
  • 医学学士, 大連医科大学

Researchmap個人ページ

ホームページURL

J-Global ID

研究キーワード

  • cytokine
  • bacterial infection
  • inflammation
  • NAFLD

研究分野

  • ライフサイエンス, 感染症内科学
  • ライフサイエンス, 消化器内科学
  • ライフサイエンス, 細菌学

担当教育組織

■研究活動情報

受賞

  • 2021年07月, 北海道大学, excellent teacher　　　　　　　　　　　　　　　
  • 2018年, 北海道大学, excellent teacher　　　　　　　　　　　　　　　
    伊 敏

論文

  • Histochemical assessment on osteoclasts in long bones of toll-like receptor 2 (TLR2) deficient mice.
    Takafumi Muneyama, Tomoka Hasegawa, Yimin, Tomomaya Yamamoto, Hiromi Hongo, Mai Haraguchi-Kitakamae, Miki Abe, Haruhi Maruoka, Hotaka Ishizu, Tomohiro Shimizu, Yasuyuki Sasano, Minqi Li, Norio Amizuka
    Journal of oral biosciences, 2023年04月21日, ［国際誌］
    英語, 研究論文（学術雑誌）, OBJECTIVE: Toll-like receptor 2 (TLR2), recognizes a wide variety of pathogen-associated molecular patterns such as lipopolysaccharides, peptidoglycans, and lipopeptides, and is generally believed to be present in monocytes, macrophages, dendritic cells, and vascular endothelial cells. However, no histological examination of osteoclasts, which differentiate from precursors common to macrophages/monocytes, has been performed in a non-infected state of TLR2 deficiency. The objective of this study was to examine the histological properties and function of osteoclasts in the long bones of 8-week-old male TLR2 deficient (TLR2-/-) mice to gain insight into TLR2 function in biological circumstances without microbial infection. METHODS: Eight-week-old male wild-type and TLR2-/- mice were fixed with paraformaldehyde solution, and their tibiae and femora were used for micro-CT analysis, immunohistochemistry, transmission electron microscopy, and real-time PCR analysis. RESULTS: TLR2-/- tibiae and femora exhibited increased bone volume of metaphyseal trabeculae and elevated numbers of TRAP-positive osteoclasts. However, the number of multinucleated TRAP-positive osteoclasts was reduced, whereas mononuclear TRAP-positive cells increased, despite the high expression levels of Dc-Stamp and Oc-Stamp. Although TRAP-positive multinucleated and mononuclear osteoclasts showed the immunoreactivity and elevated expression of RANK and siglec-15, they revealed weak cathepsin K-positivity and less incorporation of the mineralized bone matrix, and often missing ruffled borders. It seemed likely that, despite the increased numbers, TLR2-/- osteoclasts reduced cell fusion and bone resorption activity. CONCLUSION: It seems likely that even without bacterial infection, TLR2 might participate in cell fusion and subsequent bone resorption of osteoclasts.
  • Histochemical assessment of accelerated bone remodeling and reduced mineralization in Il-6 deficient mice.
    Yasuhito Moritani, Tomoka Hasegawa, Tomomaya Yamamoto, Hiromi Hongo, Yimin, Miki Abe, Hirona Yoshino, Ko Nakanishi, Haruhi Maruoka, Hotaka Ishizu, Tomohiro Shimizu, Masahiko Takahata, Norimasa Iwasaki, Minqi Li, Kanchu Tei, Yoichi Ohiro, Norio Amizuka
    Journal of oral biosciences, 2022年10月11日, ［国際誌］
    英語, 研究論文（学術雑誌）, OBJECTIVES: Interleukin-6 (IL-6) contributes to the regulation of functions in various tissues and organs. Even though IL-6 has been reported to modulate bone metabolism in previous studies, this finding is controversial. This study aims to evaluate the possible involvement of IL-6 in bone metabolism by examining the histological activity of osteoblasts and osteoclasts in the femora of Il-6 deficient (Il-6-/-) mice. METHODS: Eight-week-old male Il-6-/- mice and their wild-type littermates were fixed with a paraformaldehyde solution, and their femora were extracted for micro-CT analysis, immunohistochemistry, and real-time PCR analysis. RESULTS: Il-6-/- femora showed an increased bone volume/tissue volume (TV) but a reduced bone mineral density compared with the wild-type. Furthermore, the tissue-nonspecific alkaline phosphatase positive area/TV ratio, the expression of Runx2, Osterix, and Rankl, and the number of tartrate-resistant acid phosphatase-positive osteoclasts were all increased in the Il-6-/- mice. A considerable number of unmineralized areas within the bone matrix and abundant sclerostin-reactive osteocytes were observed in Il-6-/- femoral metaphyses but not in the wild-type. Interestingly, the gene expression of Cd206 was elevated in Il-6-/- femora, and many F4/80-positive macrophages/monocytes and CD206-immunoreactive macrophages in the primary trabeculae had migrated closer to the growth plate, where intense RANKL immunoreactivity was detected. These results suggest that, in an IL-6-deficient state, CD206-positive macrophages may differentiate into osteoclasts when in contact with RANKL-reactive osteoblastic cells. CONCLUSION: In a state of IL-6 deficiency, the population and cell activities of osteoblast, osteoclasts, and macrophages seemed to be facilitated, except for the reduced mineralization in bone.
  • Altered immunolocalization of FGF23 in murine femora metastasized with human breast carcinoma MDA-MB-231 cells.
    Ayako Yokoyama, Tomoka Hasegawa, Toru Hiraga, Tamaki Yamada, Yimin, Hiromi Hongo, Tomomaya Yamamoto, Miki Abe, Taiji Yoshida, Yasuo Imanishi, Shinichiro Kuroshima, Muneteru Sasaki, Paulo Henrique Luiz de Fraitas, Minqi Li, Norio Amizuka, Yutaka Yamazaki
    Journal of bone and mineral metabolism, 39, 5, 810, 823, 2021年09月, ［国内誌］
    英語, 研究論文（学術雑誌）, INTRODUCTION: After the onset of bone metastasis, tumor cells appear to modify surrounding microenvironments for their benefit, and particularly, the levels of circulating fibroblast growth factor (FGF) 23 in patients with tumors have been highlighted. MATERIALS AND METHODS: We have attempted to verify if human breast carcinoma MDA-MB-231 cells metastasized in the long bone of nu/nu mice would synthesize FGF23. Serum concentrations of calcium, phosphate (Pi) and FGF23 were measured in control nu/nu mice, bone-metastasized mice, and mice with mammary gland injected with MDA-MB-231 cells mimicking primary mammary tumors. RESULTS AND CONCLUSIONS: MDA-MB-231 cells revealed intense FGF23 reactivity in metastasized lesions, whereas MDA-MB-231 cells cultured in vitro or when injected into the mammary glands (without bone metastasis) showed weak FGF23 immunoreactivity. Although the bone-metastasized MDA-MB-231 cells abundantly synthesized FGF23, osteocytes adjacent to the FGF23-immunopositive tumors, unlike intact osteocytes, showed no FGF23. Despite significantly elevated serum FGF23 levels in bone-metastasized mice, there was no significant decrease in the serum Pi concentration when compared with the intact mice and mice with a mass of MDA-MB-231 cells in mammary glands. The metastasized femora showed increased expression and FGFR1 immunoreactivity in fibroblastic stromal cells, whereas femora of control mice showed no obvious FGFR1 immunoreactivity. Taken together, it seems likely that MDA-MB-231 cells synthesize FGF23 when metastasized to a bone, and thus affect FGFR1-positive stromal cells in the metastasized tumor nest in a paracrine manner.
  • Immunocytochemical assessment of cell differentiation of podoplanin-positive osteoblasts into osteocytes in murine bone.
    Tomoya Nagai, Tomoka Hasegawa, Yimin, Tomomaya Yamamoto, Hiromi Hongo, Miki Abe, Taiji Yoshida, Ayako Yokoyama, Paulo Henrique Luiz de Freitas, Minqi Li, Atsuro Yokoyama, Norio Amizuka
    Histochemistry and cell biology, 155, 3, 369, 380, 2021年03月, ［国際誌］
    英語, 研究論文（学術雑誌）, In this study, we examined the immunolocalization of podoplanin/E11, CD44, actin filaments, and phosphorylated ezrin in the osteoblasts on the verge of differentiating into osteocytes in murine femora and tibiae. When observing under stimulated emission depletion microscopy, unlike podoplanin-negative osteoblasts, podoplanin-positive osteoblasts showed a rearranged assembly of actin filaments along the cell membranes which resembled that of embedded osteocytes. In the metaphysis, i.e., the bone remodeling site, CD44-bearing osteoclasts were either proximal to or in contact with podoplanin-positive osteoblasts, but the podoplanin-positive osteoblasts also localized CD44 on their own cell surface. These podoplanin-positive osteoblasts, which either possessed CD44 on their cell surface or were close to CD44-bearing osteoclasts, showed phosphorylated ezrin-positivity on the cell membranes. Therefore, the CD44/podoplanin interaction on the cell surface may be involved in the osteoblastic differentiation into osteocytes in the metaphyses, via the mediation of podoplanin-driven ezrin phosphorylation and the subsequent reorganized assembly of actin filaments. Consistently, the protein expression of phosphorylated ezrin was increased after CD44 administration in calvarial culture. Conversely, in modeling sites such as the cortical bones, podoplanin-positive osteoblasts were uniformly localized at certain intervals even without contact with CD44-positive bone marrow cells; furthermore, they also exhibited phosphorylated ezrin immunoreactivity along their cell membranes. Taken together, it seems likely that the CD44/podoplanin interaction is involved in osteoblastic differentiation into osteocytes in the bone remodeling area but not in modeling sites.
  • Histological observation on the initial stage of vascular invasion into the secondary ossification of murine femoral epiphyseal cartilage
    Keiji Hashimoto, Tomoka Hasegawa, Tomomaya Yamamoto, Hiromi Hongo, Yimin, Miki Abe, Alireza Nasoori, Ko Nakanishi, Haruhi Maruoka, Yasuhito Morimoto, Keisuke Kubota, Tomohiro Shimizu, Mai Haraguchi, Masahiko Takahata, Norimasa Iwasaki, Minqi Li, Toshiaki Fujisawa, Norio Amizuka
    Biomedical Research (Japan), 42, 4, 139, 151, 2021年
    研究論文（学術雑誌）
  • Histological observation on the initial stage of vascular invasion into the secondary ossification of murine femoral epiphyseal cartilage
    Keiji Hashimoto, Tomoka Hasegawa, Tomomaya Yamamoto, Hiromi Hongo, Yimin, Miki Abe, Alireza Nasoori, Ko Nakanishi, Haruhi Maruoka, Yasuhito Morimoto, Keisuke Kubota, Tomohiro Shimizu, Mai Haraguchi, Masahiko Takahata, Norimasa Iwasaki, Minqi Li, Toshiaki Fujisawa, Norio Amizuka
    BIOMEDICAL RESEARCH-TOKYO, 42, 4, 139, 151, 2021年
    英語, 研究論文（学術雑誌）
  • Extracts of bilberry (Vaccinium myrtillus L.) fruits improve liver steatosis and injury in mice by preventing lipid accumulation and cell death.
    Haga S, YiMin, Yamaki H, Jin S, Sogon T, Morita N, Ozaki M
    Bioscience, biotechnology, and biochemistry, 83, 11, 2110, 2120, Oxford University Press (OUP), 2019年11月, ［査読有り］
    研究論文（学術雑誌）, ABSTRACT
    Bilberry has been reported to have anti-oxidant and anti-inflammatory properties. We studied the effect of bilberry (Vaccinium myrtillus L.) fruits extracts (BEs) on the pathogenesis caused by lipid accumulation in fatty liver and non-alcoholic steatohepatitis (NASH). 5 μg/ml of BEs was enough to suppress lipid accumulation in the fatty liver model of the mouse hepatic AML12 cells. BEs increased cell viability and anti-oxidant capacity, presumably by activating (phosphorylating) Akt/STAT3 and inducing MnSOD/catalase. BEs also significantly reduced Rubicon and induced p62/SQSTM1, possibly contributing to reduce cellular lipids (lipophagy). When the mice were fed supplemented with BEs (5% or 10%, w/w), hepatic steatosis, injury, and hypercholesterolemia/hyperglycemia were significantly improved. Furthermore, histological and cytokine studies indicated that BEs possibly suppress hepatic inflammation (hepatitis) and fibrosis. Therefore, BEs improved liver steatosis and injury, and potentially suppress fibrosis by suppressing inflammatory response, which therefore may prevent the progression of fatty liver to NASH.
  • Histochemical examination on principal collagen fibers in periodontal ligaments of ascorbic acid-deficient ODS-od/od rats
    Tomoka Hasegawa, Yukina Miyamoto-Takasaki, Miki Abe, Zixuan Qiu, Tomomaya Yamamoto, Yimin, Taiji Yoshida, Hirona Yoshino, Hiromi Hongo, Ayako Yokoyama, Muneteru Sasaki, Shinichiro Kuroshima, Kuniko Hara, Masatoshi Kobayashi, Yasuhiro Akiyama, Takeyasu Maeda, Paulo Henrique Luiz de Freitas, Minqi Li, Norio Amizuka
    MICROSCOPY, 68, 5, 349, 358, 2019年10月
    英語, 研究論文（学術雑誌）
  • Immunolocalization of podoplanin/E11/gp38, CD44, and endomucin in the odontoblastic cell layer of murine tooth germs.
    Naznin Khadiza, Tomoka Hasegawa, Tomoya Nagai, Tomomaya Yamamoto, Yukina Miyamoto-Takasaki, Hiromi Hongo, Miki Abe, Mai Haraguchi, Tsuneyuki Yamamoto, Yimin, Zixuan Qiu, Muneteru Sasaki, Shinichiro Kuroshima, Hayato Ohshima, Paulo Henrique Luiz de Freitas, Minqi Li, Yasutaka Yawaka, Norio Amizuka
    Biomedical research (Tokyo, Japan), 40, 4, 133, 143, 2019年, ［査読有り］, ［国内誌］
    英語, 研究論文（学術雑誌）, In this study, we attempted to localize the immunoreactivities of podoplanin/E11/gp38 and CD44, a counterpart possessing a high affinity to podoplanin/E11/gp38, as well as endomucin-immunoreactive blood vessels in the regions of odontoblast layers and the underlying sub-odontoblastic layers in murine tooth germs. Endomucin-reactive small blood vessels were scattered throughout the dental papillae of the tooth germs at postnatal day 1 but came to be localized close to the odontoblast/sub-odontoblastic layers until day 3. After postnatal day 5, small blood vessels were seen in odontoblast cell layers, while blood vessels with relatively larger diameters were seen forming in sub-odontoblastic layers. Immunoreactivities of podoplanin/E11/gp38 and CD44 were not detectable in the cells of dental papillae facing the inner enamel epithelium at postnatal day 1. However, at around postnatal days 3-5, podoplanin/E11/gp38 was localized in the odontoblast layer but not in the sub-odontoblastic layer, whereas CD44 was observed in the sub-odontoblastic layer but not in the odontoblast layer. The exclusive immunolocalization of podoplanin/E11/gp38 and CD44 in the odontoblast layers and sub-odontoblastic layers was seen after postnatal day 3 of the tooth germs, when the mesenchymal cells of dental papillae have already differentiated into mature odontoblasts at the cusp tip. Taken together, it seems likely that endomucin-reactive small blood vessels extended to the podoplanin/E11/gp38-positive odontoblast layers, whereas endomucin-reactive large blood vessels were already present in CD44-immmunopositive sub-odontoblastic layer, indicating the cellular regulation on the vascularization of endomucin-reactive endothelial cells during odontogenesis of the tooth germs.
  • Photo-activatable akt probe: A new tool to study the akt-dependent physiopathology of cancer cells
    Sanae Haga, Takeaki Ozawa, Naoki Morita, Mami Asano, Shigeki Jin, Yimin, Michitaka Ozaki
    Oncology Research, 26, 3, 467, 472, Cognizant Communication Corporation, 2018年, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Co-Targeting IGF-1R and Autophagy Enhances the Effects of Cell Growth Suppression and Apoptosis Induced by the IGF-1R Inhibitor NVP-AEW541 in Triple-Negative Breast Cancer Cells
    Weibin Wu, Jieyi Ma, Nan Shao, Yawei Shi, Ruiming Liu, Wen Li, Yin Lin, Shenming Wang
    PLOS ONE, 12, 1, 2017年01月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Relevance of FXR-p62/SQSTM1 pathway for survival and protection of mouse hepatocytes and liver, especially with steatosis
    Sanae Haga, Yimin, Michitaka Ozaki
    BMC GASTROENTEROLOGY, 17, 2017年01月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Oral Delivery of Pentameric Glucagon-Like Peptide-1 by Recombinant Lactobacillus in Diabetic Rats
    Yin Lin, Kasper Krogh-Andersen, Julien Pelletier, Harold Marcotte, Claes-Goran Ostenson, Lennart Hammarstrom
    PLOS ONE, 11, 9, 2016年09月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Immunolocalization of MMP9 and MMP2 in osteolytic metastasis originating from MDA-MB-231 human breast cancer cells
    Bo Liu, Jian Cui, Jing Sun, Juan Li, Xiuchun Han, Jie Guo, Min Yi, Norio Amizuka, Xin Xu, Minqi Li
    MOLECULAR MEDICINE REPORTS, 14, 2, 1099, 1106, 2016年08月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Oyster extracts attenuate pathological changes in non-alcoholic steatohepatitis (NASH) mouse model
    Mitsugu Watanabe, Hirotoshi Fuda, Hiroaki Okabe, Sae Joko, Yusuke Miura, Shu-Ping Hui, Yimin, Naohiro Hamaoka, Emiko Miki, Hitoshi Chiba
    JOURNAL OF FUNCTIONAL FOODS, 20, 516, 531, 2016年01月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Long-Term Administration of High-Fat Diet Corrects Abnormal Bone Remodeling in the Tibiae of Interleukin-6-Deficient Mice
    Wei Feng, Bo Liu, Di Liu, Tomoka Hasegawa, Wei Wang, Xiuchun Han, Jian Cui, Yimin, Kimimitsu Oda, Norio Amizuka, Minqi Li
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 64, 1, 42, 53, 2016年01月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Altered distribution of HMGB1 in the periodontal ligament of periostin-deficient mice subjected to Waldo's orthodontic tooth movement
    Juan Li, Wei Feng, Bo Liu, Bao Sun, Xiuchun Han, Juan Du, Jing Sun, Yimin, Jian Cui, Jie Guo, Akira Kudo, Norio Amizuka, Minqi Li
    JOURNAL OF MOLECULAR HISTOLOGY, 46, 3, 303, 311, 2015年06月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Histochemical evidence of zoledronate inhibiting c-src expression and interfering with CD44/OPN-mediated osteoclast adhesion in the tibiae of mice
    Hongrui Liu, Jian Cui, Jing Sun, Juan Du, Wei Feng, Bao Sun, Juan Li, Xiuchun Han, Bo Liu, Yimin, Kimimitsu Oda, Norio Amizuka, Minqi Li
    JOURNAL OF MOLECULAR HISTOLOGY, 46, 3, 313, 323, 2015年06月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Local administration of calcitriol positively influences bone remodeling and maturation during restoration of mandibular bone defects in rats
    Hongrui Liu, Jian Cui, Wei Feng, Shengyu Lv, Juan Du, Jing Sun, Xiuchun Han, Zhenming Wang, Xiong Lu, Yimin, Kimimitsu Oda, Norio Amizuka, Minqi Li
    MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 49, 14, 24, 2015年04月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Regulatory Effect of Interleukin-4 in the Innate Inflammatory Response to Rhodococcus aurantiacus Infection in Mice
    Yimin, Masashi Kohanawa, Songji Zhao, Minqi Li, Yuji Kuge, Nagara Tamaki, Masahiko Watanabe
    JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 35, 3, 222, 231, 2015年03月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Amoebal Endosymbiont Parachlamydia acanthamoebae Bn-9 Can Grow in Immortal Human Epithelial HEp-2 Cells at Low Temperature; An In Vitro Model System to Study Chlamydial Evolution
    Chikayo Yamane, Tomohiro Yamazaki, Shinji Nakamura, Junji Matsuo, Kasumi Ishida, Sumire Yamazaki, Satoshi Oguri, Natsumi Shouji, Yasuhiro Hayashi, Mitsutaka Yoshida, Yimin, Hiroyuki Yamaguchi
    PLOS ONE, 10, 2, e0116486, 2015年02月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Staging liver fibrosis by analysis of non-linear normalization texture in gadolinium-enhanced magnetic resonance imaging.　　　　　　　　　　　　　　　
    Mou W, Guo D, Liu H, Zhang P, Shao Y, Wang S, Yimin, Zheng L
    Biomedical Physics & Engineering Express, 045012, 045012., 2015年, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Feature Selection Combined with Neural Network Structure Optimization for HIV-1 Protease Cleavage Site Prediction
    Hui Liu, Xiaomiao Shi, Dongmei Guo, Zuowei Zhao, Yimin
    BIOMED RESEARCH INTERNATIONAL, 2015, 263586, 2015年, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Histological Evidence of Increased Osteoclast Cell Number and Asymmetric Bone Resorption Activity in the Tibiae of Interleukin-6-Deficient Mice
    Hongrui Liu, Wei Feng, Yimin, Jian Cui, Shengyu Lv, Tomoka Hasegawa, Bao Sun, Juan Li, Kimimitsu Oda, Norio Amizuka, Minqi Li
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 62, 8, 556, 564, 2014年08月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Contribution of Toll-Like Receptor 2 to the Innate Response against Staphylococcus aureus Infection in Mice
    Yimin, Masashi Kohanawa, Songji Zhao, Michitaka Ozaki, Sanae Haga, Guangxian Nan, Yuji Kuge, Nagara Tamaki
    PLoS ONE, 8, 9, e74287, 9, 2013年09月13日, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Chlamydophila pneumoniae in human immortal Jurkat cells and primary lymphocytes uncontrolled by interferon-γ
    Ishida K, Kubo T, Saeki A, Yamane C, Matsuo J, Yimin, Nakamura S, Hayashi Y, Kunichika M, Yoshida M, Takahashi K, Hirai I, Yamamoto Y, Shibata KI, Yamaguchi H
    Microbes and infection / Institut Pasteur, 15, 3, 192, 200, 2013年03月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Anoikis induction and inhibition of peritoneal metastasis of pancreatic cancer cells by a nuclear factor-κB inhibitor, (-)-DHMEQ.
    Sato M, Nakanishi K, Haga S, Fujiyoshi M, Baba M, Mino K, Yimin, Niwa H, Yokoo H, Umezawa K, Ohmiya Y, Kamiyama T, Todo S, Taketomi A, Ozaki M
    Oncology research, 21, 6, 333, 343, 2013年, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Ferrous Ferric Chloride Downregulates the Inflammatory Response to Rhodococcus aurantiacus Infection in Mice
    Yimin, Huirong Tao, Masashi Kohanawa, Songji Zhao, Yuji Kuge, Nagara Tamaki
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35, 12, 2214, 2223, 2012年12月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Xanthohumol Prevents Atherosclerosis by Reducing Arterial Cholesterol Content via CETP and Apolipoprotein E in CETP-Transgenic Mice
    Hiroshi Hirata, Yimin, Shuichi Segawa, Moeko Ozaki, Naoyuki Kobayashi, Tatsuro Shigyo, Hitoshi Chiba
    PLOS ONE, 7, 11, e49415, 2012年11月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • A domino-like chlamydial attachment process: concurrent Parachlamydia acanthamoebae attachment to amoebae is required for several amoebal released molecules and serine protease activity
    Yasuhiro Hayashi, Yimin, Junji Matsuo, Shinji Nakamura, Miyuki Kunichika, Mitsutaka Yoshida, Kaori Takahashi, Hiroyuki Yamaguchi
    MICROBIOLOGY-SGM, 158, 6, 1607, 1614, 2012年06月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • A novel murine model for non-alcoholic steatohepatitis developed by combination of a high-fat diet and oxidized low-density lipoprotein
    Yin Lin, Hiroaki Furumaki, Shiho Matsuoka, Toshihiro Sakurai, Masashi Kohanawa, Songji Zhao, Yuji Kuge, Nagara Tamaki, Hitoshi Chiba
    LABORATORY INVESTIGATION, 92, 2, 265, 281, 2012年02月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • 病原性クラミジアのリンパ球細胞への感染とIFN-gamma抵抗性
    石田 香澄, 久保 剛流, 伊 敏, 松尾 淳司, 中村 眞二, 山口 博之
    日本細菌学雑誌, 67, 1, 104, 104, 日本細菌学会, 2012年02月
    日本語
  • Dynamic C-11-methionine PET analysis has an additional value for differentiating malignant tumors from granulomas: an experimental study using small animal PET
    Songji Zhao, Yuji Kuge, Min Yi, Yan Zhao, Toshiyuki Hatano, Keiichi Magota, Ken-ichi Nishijima, Masashi Kohanawa, Nagara Tamaki
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 38, 10, 1876, 1886, 2011年10月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • 肉芽腫・腫瘍におけるFMISO-PETの有用性 小動物用PETを用いた基礎的検討　　　　　　　　　　　　　　　
    趙 松吉, 久下 裕司, 趙 芫, 伊 敏, 波多野 利行, 鈴木 幸太郎, 孫田 恵一, 西嶋 剣一, 小華和 柾志, 玉木 長良
    核医学, 47, 3, 373, 373, (一社)日本核医学会, 2010年09月
    日本語
  • 肉芽腫・腫瘍の鑑別診断におけるdynamic 11C-MET-PETの有用性 小動物用PETを用いた基礎的検討　　　　　　　　　　　　　　　
    趙 松吉, 久下 裕司, 伊 敏, 趙 芫, 竹内 啓, 波多野 利行, 鈴木 幸太郎, 孫田 惠一, 西嶋 剣一, 小華和 柾志, 玉木 長良
    核医学, 46, 3, 327, 327, (一社)日本核医学会, 2009年09月
    日本語
  • Mutual modulation between interleukin-10 and interleukin-6 induced by Rhodococcus aurantiacus infection in mice
    Yimin, Masashi Kohanawa, Michitaka Ozaki, Sanae Haga, Keiko Fujikawa, Songji Zhao, Yuji Kuge, Nagara Tamaki
    MICROBES AND INFECTION, 10, 14-15, 1450, 1458, 2008年11月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Usefulness of C-11-methionine for differentiating tumors from granulomas in experimental rat models: A comparison with F-18-FDG and F-18-FLT
    Songji Zhao, Yuji Kuge, Masashi Kohanawa, Toshiyuki Takahashi, Yan Zhao, Min Yi, Kakuko Kanegae, Koh-ichi Seki, Nagara Tamaki
    JOURNAL OF NUCLEAR MEDICINE, 49, 1, 135, 141, 2008年01月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • A regulatory effect of the balance between TNF-alpha and IL-6 in the granulomatous and inflammatory response to Rhodococcus aurantiacus infection in mice
    Yimin, M Kohanawa
    JOURNAL OF IMMUNOLOGY, 177, 1, 642, 650, 2006年07月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Up-regulation of granulomatous inflammation in interleukin-6 knockout mice infected with Rhodococcus aurantiacus
    Yimin, M Kohanawa, T Minagawa
    IMMUNOLOGY, 110, 4, 501, 506, 2003年12月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Lipopolysaccharide triggers invasive streptococcal disease in mice through a tumour necrosis factor-alpha-dependent mechanism
    HY Diao, M Kohanawa, Yimin, F Nakajima, Y Sato, T Minagawa, A Nakane
    IMMUNOLOGY, 105, 3, 344, 349, 2002年03月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Role of T cells in granuloma formation induced by Rhodococcus aurantiacus is independent of their interferon-gamma production
    Yimin, M Kohanawa, Y Sato, T Minagawa
    JOURNAL OF MEDICAL MICROBIOLOGY, 50, 8, 688, 694, 2001年08月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Suppression of late asthmatic response by low-dose oral administration of interferon-beta in the guinea pig model of asthma
    Y Satoh, K Kasama, M Kuwabara, Yimin, HY Diao, H Nakajima, M Kohanawa, T Minagawa
    JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 19, 8, 887, 894, 1999年08月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Movement disorders in encephalitis induced by Rhodococcus aurantiacus infection relieved by the administration of L-dopa and anti-T-cell antibodies
    Y Min, M Asano, M Kohanawa, T Minagawa
    IMMUNOLOGY, 96, 1, 10, 15, 1999年01月, ［査読有り］
    英語, 研究論文（学術雑誌）
  • PARALYSIS CAUSED BY ACUTE MYELITIS IN THEILER MURINE ENCEPHALOMYELITIS VIRUS-STRAIN GD-VII INFECTION IS INDUCED BY CD4(+) LYMPHOCYTES INFILTRATING THE SPINAL-CORD
    M KOHANAWA, M ASANO, Y MIN, T MINAGAWA, A NAKANE
    JOURNAL OF GENERAL VIROLOGY, 76, 2251, 2256, 1995年09月, ［査読有り］
    英語, 研究論文（学術雑誌）

その他活動・業績

書籍等出版物

  • 感染症におけるサイトカインとTh細胞　　　　　　　　　　　　　　　
    インターフェロン その研究の歩みと臨床応用への可能性, 1998年

講演・口頭発表等

  • Regulatory action of toll-like receptor 2 in a non-alcoholic steatohepatitis mouse model　　　　　　　　　　　　　　　
    伊 敏
    5th Annual Meeting of the International Cytokine and interferon Society, 2017年10月, 英語, ポスター発表
    ［国際会議］
  • Function of Toll-like receptor 2 in the murine inflammatory response to Rhodococcus aurantiacus infection　　　　　　　　　　　　　　　
    伊 敏
    4th Annual Meeting of the International Cytokine and interferon Society, San Francisco, 2016年10月, 英語, ポスター発表
    ［国際会議］
  • Regulatory effect of interleukin-4 in the innate immune and inflammatory responses to Rhodococcus aurantiacus infection in mice　　　　　　　　　　　　　　　
    伊 敏
    2th Annual Meeting of the International Cytokine and Interferon Society, 2014年10月, 英語, ポスター発表
    ［国際会議］
  • Down-regulatory effect of Pairogen, a health drink, on inflammatory response to Rhodococcus aurantiacus infection in mice　　　　　　　　　　　　　　　
    伊 敏
    10th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research, 2012年09月, 英語, ポスター発表
    ［国際会議］
  • The roles of TLR2 and CD36 in response to Staphylococcus aureus in vivo　　　　　　　　　　　　　　　
    伊敏
    8th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research, 2010年10月, 英語, ポスター発表
    ［国際会議］
  • CD36 function in a novel non-alcoholic steatohepatitis model in mice　　　　　　　　　　　　　　　
    伊敏
    14th international congress of immunology, 2010年08月, 英語, ポスター発表
    ［国際会議］
  • Interaction between IL-10 and IL-6 in mice infected with Rodococcus aurantiacus.　　　　　　　　　　　　　　　
    伊敏
    4th Congress of the Federation of Immunology societies of Asia-Oceania, 2008年10月, 英語, ポスター発表
    ［国際会議］
  • A regulatory effect of the balance between tumor necrosis factor-alpha and interleukine-6 in inflammatory response.　　　　　　　　　　　　　　　
    伊敏
    6th Joint Meeting of International Cytokine Society, 2006年08月, 英語, ポスター発表
    ［国際会議］

担当経験のある科目_授業

  • 生物学実習　　　　　　　　　　　　　　　
    北海道大学
  • 細菌学　　　　　　　　　　　　　　　
    北海道大学
  • 初級中国語演習　　　　　　　　　　　　　　　
    北海道大学
  • 中級英語演習　　　　　　　　　　　　　　　
    北海道大学
  • 免疫学　　　　　　　　　　　　　　　
    北海道大学

所属学協会

  • 日本インターフェロンサイトカイン学会　　　　　　　　　　　　　　　
  • 日本免疫学会　　　　　　　　　　　　　　　
  • 日本感染症学会　　　　　　　　　　　　　　　

共同研究・競争的資金等の研究課題

  • 自然免疫異常によるグラム陽性菌感染症の重症化機序についての解析　　　　　　　　　　　　　　　
    基盤研究（C）
    2017年04月 - 2020年03月
    伊敏
    日本学術振興会, 研究代表者, 競争的資金
  • 細胞死による積極的な肝機能維持・再生制御機構の解明と臨床応用に向けた研究　　　　　　　　　　　　　　　
    挑戦的萌芽研究
    2014年04月 - 2015年03月
    伊敏
    日本学術振興会, 研究代表者, 競争的資金
  • パイロゲンの免疫防御反応への制御について　　　　　　　　　　　　　　　
    交流助成金
    2012年04月 - 2013年03月
    伊敏
    伊藤医薬学術交流財団, 研究代表者, 競争的資金
  • 炎症性サイトカインと抗炎症性サイトカインのバランスの制御機構の解明に関する研究　　　　　　　　　　　　　　　
    学術研究助成奨励金
    2008年04月 - 2009年03月
    伊敏
    日本ワックスマン財団, 研究代表者, 競争的資金
  • サルコイドーシス病因の細菌学的検索と免疫療法の確立
    科学研究費補助金(基盤研究(B))
    1996年 - 1998年
    皆川 知紀, 佐藤 雄一郎, 小華和 柾志, 伊 敏
    サルコイドーシスは、非壊死性肉芽腫が各種臓器に形成される原因不明全身性炎症性疾患である。これまで患者病的材料を用いて、病因の追求及び患者の免疫学的側面をサイトカインネットワークから追求してきた。一方で、マウスを用いた実験的肉芽腫形成モデルについて追求してきた。1.病因については結核説、プロピオニバクテリウム説が現在の所有力であるが、それらのいずれかが単独で発症させる可能性は少なく、むしろ多因子の背景があるところへある種の感染が引き金となつている可能性が強い。我々は非病原性であり、土壌細菌(環境細菌)出来でもあるRhodococcus aurantiacusも原因の一つになりえるとの立場から検索したが、患者リンパ節からは有意には分離されなかった。2.サルコイドーシス患者の免疫学的特性としてツベルクリン反応が陰性であるアネルギーがあるが、それは全身性の肉芽腫反応の結果であり、免疫不全を意味しない。患者リンパ節の肉芽腫病変よりIL-1、TNFα、IFN-γが検出されるが中でもIFN―γは血中レベル、病勢と相関している事を明らかにした。免疫組織染色などからもサルコイドーシス肉芽腫形成はThlタイプの反応の結果であることを明らかにした。3.Rhodococcusをマウスに静注すると肝臓、牌臓、肺などに典型的な非壊死性肉芽腫が形成されるが、これもサルコイドーシス同様Th1タイプの反応の結...
    文部科学省, 基盤研究(B), 北海道大学, 連携研究者, 競争的資金, 08457084
  • Study on Mechanism of Granuloma Formation　　　　　　　　　　　　　　　
    競争的資金