Kato Tatsuya

Hokkaido University HospitalProfessor
Last Updated :2025/06/07

■Researcher basic information

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Researcher number

  • 20624232

J-Global ID

Educational Organization

■Research activity information

Awards

  • Oct. 2008, 日本癌学会, 奨励賞　　　　　　　　　　　　　　　
    加藤達哉

Papers

  • The role of the stapled interlobar fissure position for intraoperative detection and postoperative diagnosis of middle lobe torsion after right upper lobectomy.
    Kazuto Ohtaka, Setsuyuki Ohtake, Aki Fujiwara-Kuroda, Sho Narita, Shinya Otsuka, Hiroshi Yamasaki, Akihiro Sasaki, Haruhiko Shiiya, Hideki Ujiie, Masato Aragaki, Tatsuya Kato
    Journal of thoracic disease, 17, 3, 1268, 1277, 31 Mar. 2025, [International Magazine]
    English, Scientific journal, BACKGROUND: Lung torsion is caused by the lung twisting around the hilum, leading to severe conditions with a high mortality rate. We evaluated the usefulness of the stapled interlobar fissure (SIF) position for intraoperative detection and postoperative early diagnosis of middle lobe (ML) torsion after right upper lobectomy (RUL). METHODS: This retrospective study included 271 patients who underwent RUL at the Hokkaido University Hospital or Obihiro Kosei General Hospital. We assessed the SIF position between the upper lobe and ML on postoperative computed tomography (CT) scans and surgical videos, and correlated it with postoperative abnormalities in the ML, such as atelectasis or rotation of the bronchus and pulmonary vessels. RESULTS: On postoperative CT scans, the SIF position was on the interlobar side in 24 (96.0%) of 25 patients with abnormal findings in the ML, and on the mediastinal side in 224 (91.1%) of 246 patients without abnormalities (P<0.001). The sensitivity and specificity were 96.0% and 91.1%, respectively. At the end of the surgery, the SIF position was on the interlobar side in 10 (90.9%) of 11 patients with abnormal findings in the ML, and on the mediastinal side in 53 (86.9%) of 61 patients without abnormalities (P<0.001). The sensitivity and specificity were 90.9% and 86.9%, respectively. CONCLUSIONS: The SIF position observed at the end of the surgery and on postoperative CT scans was significantly associated with postoperative ML abnormalities. Therefore, observing SIF positions intraoperatively and on postoperative CT may aid in intraoperative detection and postoperative diagnosis of ML torsion after RUL.
  • Outcomes of Surgical Lung Biopsy in Pleuroparenchymal Fibroelastosis: A Single-center Retrospective Study.
    Haruhiko Shiiya, Tomohiko Nakamura, Hideki Ujiie, Kazuto Ohtaka, Aki Fujiwara-Kuroda, Masato Aragaki, Kazufumi Okada, Tatsuya Kato
    Archivos de bronconeumologia, 29 Nov. 2024, [International Magazine]
    English, Scientific journal
  • 肺虚血再灌流傷害におけるエリスロポエチンアナログ製剤の効果　　　　　　　　　　　　　　　
    椎谷 洋彦, 渡辺 正明, 千葉 龍平, 佐々木 明洋, 大高 和人, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加藤 達哉
    移植, 59, 総会臨時, 375, 375, (一社)日本移植学会, Sep. 2024
    Japanese
  • 肺癌におけるCD73に対する近赤外線免疫療法(NIR-PIT)と抗PD-1抗体の併用療法の有効性(Efficacy of Combined Therapy with Near-Infrared Photoimmunotherapy Targeting CD73 and Anti-PD-1 Antibody in Lung Cancer)　　　　　　　　　　　　　　　
    千葉 龍平, 中島 孝平, 畑中 佳奈子, 氏家 秀樹, 新垣 雅人, 小林 拓馬, 小西 哲平, 畑中 豊, 加藤 達哉, 小川 美香子, 小川 美香子
    日本癌学会総会記事, 83回, P, 1234, (一社)日本癌学会, Sep. 2024
    English
  • 肺虚血再灌流傷害におけるエリスロポエチンアナログ製剤の効果　　　　　　　　　　　　　　　
    椎谷 洋彦, 渡辺 正明, 千葉 龍平, 佐々木 明洋, 大高 和人, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加藤 達哉
    移植, 59, 総会臨時, 375, 375, (一社)日本移植学会, Sep. 2024
    Japanese
  • 先天性嚢胞性肺疾患に対するReduced port VATSの取り組み　　　　　　　　　　　　　　　
    藤原 晶, 高桑 佑佳, 佐々木 明洋, 椎谷 洋彦, 大高 和人, 氏家 秀樹, 新垣 雅人, 本多 昌平, 川原 仁守, 加藤 達哉
    日本気胸・嚢胞性肺疾患学会雑誌, 24, 2, 86, 86, 日本気胸・嚢胞性肺疾患学会, Aug. 2024
    Japanese
  • 先天性嚢胞性肺疾患に対するReduced port VATSの取り組み　　　　　　　　　　　　　　　
    藤原 晶, 高桑 佑佳, 佐々木 明洋, 椎谷 洋彦, 大高 和人, 氏家 秀樹, 新垣 雅人, 本多 昌平, 川原 仁守, 加藤 達哉
    日本気胸・嚢胞性肺疾患学会雑誌, 24, 2, 86, 86, 日本気胸・嚢胞性肺疾患学会, Aug. 2024
    Japanese
  • 肺移植クラウドファンディングを経験して
    加藤 達哉, 大塚 将平, 佐々木 明洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 氏家 秀樹, 新垣 雅人
    移植, 59, 1, 101, 101, (一社)日本移植学会, Jul. 2024
    Japanese
  • ラット虚血再灌流傷害モデルを用いた新規抗炎症薬による肺傷害抑制効果の検討　　　　　　　　　　　　　　　
    椎谷 洋彦, 千葉 龍平, 渡辺 正明, 大塚 将平, 佐々木 明洋, 大高 和人, 氏家 秀樹, 藤原 晶, 新垣 雅人, 加藤 達哉
    移植, 59, 1, 88, 88, (一社)日本移植学会, Jul. 2024
    Japanese
  • 肺移植クラウドファンディングを経験して　　　　　　　　　　　　　　　
    加藤 達哉, 大塚 将平, 佐々木 明洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 氏家 秀樹, 新垣 雅人
    移植, 59, 1, 101, 101, (一社)日本移植学会, Jul. 2024
    Japanese
  • Epithelioid pleural mesothelioma successfully treated with perioperative immunotherapy: a case report.
    Gaku Yamazaki, Aki Fujiwara-Kuroda, Jun Muto, Hideki Ujiie, Masato Aragaki, Megumi Furuta, Sakurako Ohno, Kanako C Hatanaka, Yutaka Hatanaka, Yoshihiro Matsuno, Tatsuya Kato
    General Thoracic and Cardiovascular Surgery Cases, 3, 1, 31, 31, 11 Jun. 2024, [International Magazine]
    English, Scientific journal, BACKGROUND: Pleural mesothelioma, characterized by a dismal prognosis even with multimodal therapy, has seen emerging interest in immune checkpoint inhibitors (ICIs) due to their demonstrated efficacy. Here, we present a case of epithelioid-type pleural mesothelioma with chest wall invasion treated with definitive ICI therapy, resulting in a remarkable pretreatment effect. CASE PRESENTATION: A 46-year-old man was diagnosed with an abnormal chest shadow on a medical check, and a computed tomography scan showed pleural thickening at the dorsal right upper chest wall. One of the nodules was suspected to have invaded the chest wall. A needle biopsy revealed epithelioid-type pleural mesothelioma. After five cycles of nivolumab plus ipilimumab, he underwent right pleurectomy/decortication (P/D). Pathological examination revealed a significant treatment effect, showing numerous lymphocytes infiltrating the tumor nodule and viable tumor cells localized at approximately 6 mm. CONCLUSION: Although further accumulation of cases is required to evaluate the effectiveness and case selection, P/D after immunotherapy is a useful curative treatment option for advanced pleural mesothelioma.
  • 右大腿発生粘液型脂肪肉腫に肺転移を擬した肺クリプトコッカス病を併発した1例
    河村 茉莉子, 松岡 正剛, 氏家 秀樹, 有賀 伸, 中里 信一, 加藤 憲士郎, 橋本 孝之, 松野 吉宏, 加藤 達哉, 岩崎 倫政
    日本整形外科学会雑誌, 98, 6, S1566, S1566, (公社)日本整形外科学会, Jun. 2024
    Japanese
  • 右大腿発生粘液型脂肪肉腫に肺転移を擬した肺クリプトコッカス病を併発した1例　　　　　　　　　　　　　　　
    河村 茉莉子, 松岡 正剛, 氏家 秀樹, 有賀 伸, 中里 信一, 加藤 憲士郎, 橋本 孝之, 松野 吉宏, 加藤 達哉, 岩崎 倫政
    日本整形外科学会雑誌, 98, 6, S1566, S1566, (公社)日本整形外科学会, Jun. 2024
    Japanese
  • Impact of pulmonary vein-first ligation during lobectomy on the postoperative survival and recurrence rates in patients with non-small cell lung cancer: a multicenter propensity score-matched study.
    Haruhiko Shiiya, Hideki Ujiie, Ryohei Chiba, Shunsuke Nomura, Kazuto Ohtaka, Aki Fujiwara-Kuroda, Masato Aragaki, Keita Takahashi, Kazufumi Okada, Tatsuya Kato
    Surgery today, 30 May 2024, [Domestic magazines]
    English, Scientific journal, PURPOSE: Surgical manipulation of the lungs increases the number of circulating tumor cells and the subsequent risk of metastasis in patients with lung cancer. This study investigated whether or not ligating the tumor-draining pulmonary vein first during lobectomy could improve the prognosis of these patients. METHODS: We retrospectively evaluated patients who underwent curative lobectomy for solitary nonsmall-cell lung carcinoma between January 2012 and December 2016. We divided the patients into the vein-first group, in which all associated pulmonary veins were dissected and severed before cutting the pulmonary artery, bronchus, or pulmonary fissure, and the other procedure group. RESULTS: Overall, we included 177 and 413 patients in the vein-first and other procedure groups, respectively. Propensity score matching yielded 67 pairs of patients. The 5-year overall survival (85.6% [95% confidence interval, 77.3-94.8%] vs. 69.4% [58.7-81.9%], P = 0.03%) and recurrence-free survival (73.4% [63.3-85.1%] vs. 53.5% [42.5-67.3%], P = 0.02) were significantly better in the vein-first group than in the other procedure group. The cumulative recurrence rate at 5 years post-surgery was significantly lower in the vein-first group than in the other procedure group (21.7% vs. 38.3%, P = 0.04). CONCLUSION: Our study suggests that ligating the pulmonary vein first during lobectomy for lung cancer can improve the overall survival, recurrence-free survival, and cumulative recurrence rate.
  • Dose Optimization of Intravenous Indocyanine Green for Malignant Lung Tumor Localization
    Hideki Ujiie, Ryohei Chiba, Akihiro Sasaki, Shunsuke Nomura, Haruhiko Shiiya, Shohei Otsuka, Hiroshi Yamasaki, Aki Fujiwara-Kuroda, Kazuto Ohtaka, Masato Aragaki, Kazufumi Okada, Yuma Ebihara, Tatsuya Kato
    Journal of Clinical Medicine, 13, 10, 2807, 2807, MDPI AG, 10 May 2024
    Scientific journal, Background: Intravenously administered indocyanine green (ICG) accumulates in lung tumors, facilitating their detection via a fluorescence spectrum measurement. This method aids in identifying tumor locations that are invisible to the naked eye. We aim to determine the optimal ICG dose and administration method for accurate tumor identification during lung resection surgeries, utilizing a novel ICG fluorescence spectroscopy system for precise tumor localization. Materials and Methods: ICG should be dissolved in the provided solution or distilled water and administered intravenously approximately 24 h before surgery, beginning with an initial dose of 0.5 mg/kg. If the tumor detection rate is insufficient, the dose may be gradually increased to a maximum of 5.0 mg/kg to determine the optimal dosage for effective tumor detection. This fluorescence spectroscopy during surgery may reveal additional lesions that remain undetected in preoperative assessments. The primary endpoint includes the correct diagnostic rate of tumor localization. The secondary endpoints include the measurement of the intraoperative ICG fluorescence spectral intensity in lung tumors, the assessment of the operability and safety of intraperitoneal ICG administrations, the measurement of the ICG fluorescence spectral intensity in surgical specimens, the comparison of the spectral intensity in lung tissues during collapse and expansion, the correlation between ICG camera images and fluorescence spectral intensity, and the comparison of fluorescence analysis results with histopathological findings. The trial has been registered in the jRCT Clinical Trials Registry under the code jRCTs011230037. Results and Conclusions: This trial aims to establish an effective methodology for localizing and diagnosing malignant lung tumors, thereby potentially improving surgical outcomes and refining treatment protocols.
  • 低侵襲手術の未来像 Reduced port Robot-assisted thoracic surgery(RATS)の未来
    氏家 秀樹, 大塚 将平, 佐々木 明洋, 山崎 洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 新垣 雅人, 江花 弘基, 加藤 達哉
    気管支学, 46, Suppl., S171, S171, (一社)日本呼吸器内視鏡学会, May 2024
    Japanese
  • 低侵襲手術の未来像 Reduced port Robot-assisted thoracic surgery(RATS)の未来
    氏家 秀樹, 大塚 将平, 佐々木 明洋, 山崎 洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 新垣 雅人, 江花 弘基, 加藤 達哉
    気管支学, 46, Suppl., S171, S171, (一社)日本呼吸器内視鏡学会, May 2024
    Japanese
  • A simple and safe surgical technique for nonpalpable lung tumors: One-stop Solution for a nonpalpable lung tumor, Marking, Resection, and Confirmation of the surgical margin in a Hybrid operating room (OS-MRCH).
    Aki Fujiwara-Kuroda, Masato Aragaki, Yasuhiro Hida, Hideki Ujiie, Kazuto Ohtaka, Haruhiko Shiiya, Kichizo Kaga, Tatsuya Kato
    Translational lung cancer research, 13, 3, 603, 611, 29 Mar. 2024, [International Magazine]
    English, Scientific journal, When performing thoracoscopic partial resections of nonpalpable lung tumors such as ground-glass opacities (GGOs) and small tumors, detecting the location of the lesion and assessing the resection margins can be challenging. We have developed a novel method to ease this difficulty, the One-stop Solution for a nonpalpable lung tumor, Marking, Resection, and Confirmation of the surgical margin in a Hybrid operating room (OS-MRCH), which uses a hybrid operating room wherein the operating table is seamlessly integrated with cone-beam computed tomography (CBCT). We performed the OS-MRCH method on 62 nodules including primary lung cancer presenting with GGO. Identification of the lesion and confirmation of the margin were performed in 58 of the cases, while nodules were detected in all. The frequency of computed tomography (CT) scans performed prior to resection was one time in 51 cases, two times in eight cases, and ≥3 times in three cases. Additional resection was performed in two cases. The median operative time was 85.0 minutes, and the median pathological margin was 11.0 mm. The key advantages of this method are that all surgical processes can be completed in a single session, specialized skill sets are not required, and it is feasible to perform in any facility equipped with a hybrid operating room. To overcome its disadvantages, such as longer operating time and limited patient positioning, we devised various methods for positioning patients and for CT imaging of the resected specimens. OS-MRCH is a simple, useful, and practical method for performing thoracoscopic partial resection of nonpalpable lung tumors.
  • びまん性肺胞出血を呈したリンパ脈管筋腫症の一例
    木村 太俊, 武井 望, 小熊 昂, 堀井 洋志, 中村 順一, 中久保 祥, 木村 孔一, 鈴木 雅, 大高 和人, 加藤 達哉, 大川 紘弥, 松野 吉宏, 今野 哲
    日本呼吸器学会誌, 13, 増刊, 244, 244, (一社)日本呼吸器学会, Mar. 2024
    Japanese
  • 肺病立性毛細血管腫の2切除例と文献的考察　　　　　　　　　　　　　　　
    大川 紘弥, 外丸 詩野, 若林 健人, 中里 信一, 岡崎 ななせ, 加藤 憲士郎, 宮石 陸, 氏家 秀樹, 加藤 達哉, 松野 吉宏
    日本病理学会会誌, 113, 1, 362, 362, (一社)日本病理学会, Feb. 2024
    Japanese
  • 低血糖発作を合併した胸膜孤立性線維性腫瘍の1例　　　　　　　　　　　　　　　
    村本 朋之, 中川 純一, 常田 慧徳, 高橋 文也, 木村 理奈, 西岡 典子, 坂本 圭太, 加藤 扶美, 氏家 秀樹, 加藤 達哉, 大藤 悠里, 亀田 啓, 中村 昭伸, 若林 健人, 松野 吉宏, 工藤 與亮
    Japanese Journal of Radiology, 42, Suppl., 4, 4, (公社)日本医学放射線学会, Feb. 2024
    Japanese
  • 肺孤立性毛細血管腫の2症例
    大川 紘弥, 若林 健人, 中里 信一, 加藤 憲士郎, 宮石 陸, 松野 吉宏, 氏家 秀樹, 加藤 達哉
    肺癌, 64, 1, 58, 58, (NPO)日本肺癌学会, Feb. 2024
    Japanese
  • 肺病立性毛細血管腫の2切除例と文献的考察　　　　　　　　　　　　　　　
    大川 紘弥, 外丸 詩野, 若林 健人, 中里 信一, 岡崎 ななせ, 加藤 憲士郎, 宮石 陸, 氏家 秀樹, 加藤 達哉, 松野 吉宏
    日本病理学会会誌, 113, 1, 362, 362, (一社)日本病理学会, Feb. 2024
    Japanese
  • 低血糖発作を合併した胸膜孤立性線維性腫瘍の1例　　　　　　　　　　　　　　　
    村本 朋之, 中川 純一, 常田 慧徳, 高橋 文也, 木村 理奈, 西岡 典子, 坂本 圭太, 加藤 扶美, 氏家 秀樹, 加藤 達哉, 大藤 悠里, 亀田 啓, 中村 昭伸, 若林 健人, 松野 吉宏, 工藤 與亮
    Japanese Journal of Radiology, 42, Suppl., 4, 4, (公社)日本医学放射線学会, Feb. 2024
    Japanese
  • Developing a Virtual Reality Simulation System for Preoperative Planning of Robotic-Assisted Thoracic Surgery
    Hideki Ujiie, MD, PhD, Ryohei Chiba, Aogu Yamaguchi, Shunsuke Nomura, Haruhiko Shiiya, Aki Fujiwara-Kuroda, Kichizo Kaga, Chad Eitel, Tod Clapp, Tatsuya Kato
    Journal of Clinical Medicine, 21 Jan. 2024
    Scientific journal
  • 肺転移との鑑別を要した右大腿発生粘液型脂肪肉腫に伴う肺クリプトコッカス病の一例
    河村 茉莉子, 松岡 政剛, 岩崎 倫政, 氏家 秀樹, 加藤 達哉, 有賀 伸, 中里 信一, 加藤 憲士郎, 松野 吉宏, 橋本 孝之
    北海道整形災害外科学会雑誌, 66, 143rd suppl, 44, 44, 北海道整形災害外科学会, 2024
    Japanese
  • 肺転移との鑑別を要した右大腿発生粘液型脂肪肉腫に伴う肺クリプトコッカス病の一例
    河村 茉莉子, 松岡 政剛, 岩崎 倫政, 氏家 秀樹, 加藤 達哉, 有賀 伸, 中里 信一, 加藤 憲士郎, 松野 吉宏, 橋本 孝之
    北海道整形災害外科学会雑誌, 66, 143rd suppl, 44, 44, 北海道整形災害外科学会, 2024
    Japanese
  • 薄壁空洞性病変を呈した原発性肺扁平上皮内癌の1例
    佐々木 明洋, 新垣 雅人, 竹野 巨樹, 山崎 洋, 野村 俊介, 大高 和人, 藤原 晶, 氏家 秀樹, 榊原 純, 大川 紘弥, 松野 吉宏, 加藤 達哉
    気管支学, 45, 6, 443, 443, (一社)日本呼吸器内視鏡学会, Nov. 2023
    Japanese
  • 手術記録におけるメディカルイラストの利用　　　　　　　　　　　　　　　
    加賀 基知三, 藤原 晶, 新垣 雅人, 氏家 秀樹, 加藤 達哉
    日本臨床外科学会雑誌, 84, 増刊, S111, S111, 日本臨床外科学会, Oct. 2023
    Japanese
  • Tumor-to-thoracic height ratio as an easy method to predict the feasibility of reduced-port video-assisted thoracic surgery for mediastinal lesions in children: a single-center experience.
    Haruhiko Shiiya, Kichizo Kaga, Hideki Ujiie, Aki Fujiwara-Kuroda, Jun Muto, Shunsuke Nomura, Shohei Honda, Tatsuya Kato
    Journal of thoracic disease, 15, 9, 5020, 5028, 28 Sep. 2023, [International Magazine]
    English, Scientific journal, In the last few decades, reduced-port video-assisted thoracic surgery (RP-VATS) has been developed to minimize surgical invasiveness. Nevertheless, VATS in children can occasionally be difficult because the lesion occupies a small thoracic cavity, limiting the working space. This study aimed to assess the feasibility of RP-VATS for the resection of mediastinal lesions in children in association with the tumor-to-thoracic height ratio (TTH ratio). We reviewed all patients aged ≤10 years who underwent resection for mediastinal lesions in our institute between January 2008 and August 2022. Patients who underwent diagnostic procedures were excluded from this study. The TTH ratio was calculated as tumor height divided by thoracic height. Seven patients in the RP-VATS group and six in the conventional procedures (multi-portal VATS or open surgery) group were included in this study. The TTH ratio was significantly lower in the RP-VATS group than in the conventional procedures group (median, 26.3% vs. 50.8%; P=0.007). The operating time (P=0.01) and duration of drainage (P=0.003) were significantly shorter and the blood loss (P=0.001) was significantly lower in the RP-VATS group than in the conventional procedures group. After adjusting for age, a lower TTH ratio was significantly associated with the completion of RP-VATS (odds ratio: 0.776; 95% confidence interval: 0.529-0.926; P=0.048). In conclusion, RP-VATS can be performed appropriately in carefully selected cases of pediatric mediastinal lesions. A low TTH ratio may predict the feasibility of RP-VATS. Further studies are warranted to determine the criteria for the indications of RP-VATS in children, so that more children can benefit from RP-VATS.
  • Identification of micro-recurrent lesions using methylene blue for mediastinal ectopic parathyroid adenoma: a case report(タイトル和訳中)　　　　　　　　　　　　　　　
    Nomura Shunsuke, Ujiie Hideki, Fujiwara-Kuroda Aki, Kaga Kichizo, Aragaki Masato, Muto Jun, Chiba Ryohei, Yamazaki Gaku, Wakabayashi Kento, Matsuno Yoshihiro, Kato Tatsuya
    General Thoracic and Cardiovascular Surgery Cases, 2, 1 of 4, 4 of 4, BioMed Central, Aug. 2023
    English
  • 肺胞出血を合併したLymphangioleiomyomatosisの1例　　　　　　　　　　　　　　　
    大高 和人, 竹野 巨樹, 山崎 洋, 佐々木 明洋, 野村 俊介, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加藤 達哉, 武井 望, 小熊 昂, 今野 哲, 大川 紘弥, 松野 吉宏
    日本気胸・嚢胞性肺疾患学会雑誌, 23, 2, 90, 90, 日本気胸・嚢胞性肺疾患学会, Aug. 2023
    Japanese
  • 肺胞出血を合併したLymphangioleiomyomatosisの1例　　　　　　　　　　　　　　　
    大高 和人, 竹野 巨樹, 山崎 洋, 佐々木 明洋, 野村 俊介, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加藤 達哉, 武井 望, 小熊 昂, 今野 哲, 大川 紘弥, 松野 吉宏
    日本気胸・嚢胞性肺疾患学会雑誌, 23, 2, 90, 90, 日本気胸・嚢胞性肺疾患学会, Aug. 2023
    Japanese
  • 気管支3Dモデルを用いた手術シミュレーション　　　　　　　　　　　　　　　
    藤原 晶, 山崎 雅久, 千葉 龍平, 野村 俊介, 武藤 潤, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 道田 共博, 若林 侑輝, 佐伯 和紀, 山口 仰, 加藤 達哉
    日本呼吸器外科学会雑誌, 37, 3, O39, 6, (一社)日本呼吸器外科学会, Jun. 2023
    Japanese
  • 術後経時的ctDNA測定と腫瘍マーカーを併用した肺癌術後フォローアップ法は再発検出率を向上させる　　　　　　　　　　　　　　　
    加藤 達哉, Ming Chin Yoon, Low Siew-Kee, 清谷 一馬, 氏家 秀樹, 藤原 晶, 新垣 雅人, 中村 祐輔
    日本呼吸器外科学会雑誌, 37, 3, O52, 3, (一社)日本呼吸器外科学会, Jun. 2023
    Japanese
  • 術前、術後免疫チェックポイント阻害薬および肺剥皮術による集学的治療を行ったびまん性胸膜中皮腫の1例　　　　　　　　　　　　　　　
    山崎 雅久, 藤原 晶, 千葉 龍平, 野村 俊介, 武藤 潤, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 古田 恵, 大野 桜子, 松野 吉宏, 加藤 達哉
    日本呼吸器外科学会雑誌, 37, 3, O59, 2, (一社)日本呼吸器外科学会, Jun. 2023
    Japanese
  • 左上葉切除後の脳梗塞発症予防として肺静脈心嚢内処理を施行した症例の検討　　　　　　　　　　　　　　　
    武藤 潤, 山崎 雅久, 千葉 龍平, 野村 俊介, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 加藤 達哉
    日本呼吸器外科学会雑誌, 37, 3, O73, 5, (一社)日本呼吸器外科学会, Jun. 2023
    Japanese
  • 巨大ダンベル型脊髄腫瘍に対する、後方アプローチおよびロボット支援下手術(RATS)　　　　　　　　　　　　　　　
    氏家 秀樹, 中谷 匠, 山崎 雅久, 野村 俊介, 千葉 龍平, 武藤 潤, 藤原 晶, 新垣 雅人, 加賀 基知三, 高畑 雅彦, 松野 吉宏, 加藤 達哉
    日本呼吸器外科学会雑誌, 37, 3, P42, 1, (一社)日本呼吸器外科学会, Jun. 2023
    Japanese
  • 多発胸腺腫疑いに対し手術を施行し、胸腺癌と胸腺腫の同時多発が判明した1例　　　　　　　　　　　　　　　
    中谷 匠, 野村 俊介, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 加藤 憲士郎, 松野 吉宏, 加藤 達哉
    日本呼吸器外科学会雑誌, 37, 3, P68, 7, (一社)日本呼吸器外科学会, Jun. 2023
    Japanese
  • High density and proximity of CD8+ T cells to tumor cells are correlated with better response to nivolumab treatment in metastatic pleural mesothelioma.
    Yuting Yin, Rie Sakakibara, Takayuki Honda, Susumu Kirimura, Pissacha Daroonpan, Masashi Kobayashi, Kohei Ando, Hideki Ujiie, Tatsuya Kato, Kichizo Kaga, Takahiro Mitsumura, Ryoji Nakano, Hiroyuki Sakashita, Shinichi Matsuge, Hironori Ishibashi, Takumi Akashi, Yasuhiro Hida, Takao Morohoshi, Miyuki Azuma, Kenichi Okubo, Yasunari Miyazaki
    Thoracic cancer, 14, 20, 1991, 2000, 30 May 2023, [International Magazine]
    English, Scientific journal, BACKGROUND: The efficacy of immune checkpoint inhibitors (ICIs) in pleural mesothelioma has recently been established. The response to ICIs can be predicted by quantitative analysis of cells and their spatial distribution in the tumor microenvironment (TME). However, the detailed composition of the TME in pleural mesothelioma has not been reported. We evaluated the association between the TME and response to ICIs in this cancer. METHODS: A retrospective analysis of 22 pleural mesothelioma patients treated with nivolumab in different centers was performed using surgical specimens. Four patients had a partial response to nivolumab (response group) and 18 patients had stable or progressive disease (nonresponse group). The number of CD4, CD8, FoxP3, CK, and PD-L1 positive cells, cell density, and cell-to-cell distance were analyzed by multiplex immunofluorescence. RESULTS: PD-L1 expression did not differ significantly between the response and nonresponse groups. The density of total T cells and of CD8+ T cells was significantly higher in the response than in the nonresponse group. CD8+ T cells were more clustered and located closer to tumor cells, whereas regulatory T cells were located further from tumor cells in the response than in the nonresponse group. CONCLUSIONS: High density and spatial proximity of CD8+ T cells to tumor cells were associated with better response to nivolumab, whereas the proximity of regulatory T cells to tumor cells was associated with worse response, suggesting that the distinct landscape of the TME could be a potential predictor of ICI efficacy in pleural mesothelioma.
  • Invasive thymoma metastases to the pancreas: A case report.
    Shinya Otsuka, Kei Hiraoka, Noriko Kimura, Satoshi Hirano, Tatsuya Kato, Masato Suzuoki
    International journal of surgery case reports, 105, 108004, 108004, Apr. 2023, [International Magazine]
    English, INTRODUCTION AND IMPORTANCE: Thymoma is the most common type of tumor that develops in the thymic epithelial cells. Although thymomas can invade surrounding organs in the chest cavity, extrathoracic metastasis is very rare, and little is known about the prognosis and effective treatments for such tumors. Herein, we report a case of an invasive thymoma metastasizing to the pancreas after incomplete resection. CASE PRESENTATION: A 47-year-old man presented to our hospital with an anterior mediastinal mass. Although a thymic tumor was suspected, complete resection was not achieved because the tumor had invaded the pulmonary artery trunk, superior pulmonary vein, and left brachiocephalic vein. The pathological diagnosis was a Type B3 thymoma. The patient underwent chemotherapy and radiotherapy after surgery. Three years after surgery, computed tomography indicated a pancreatic mass suggestive of pancreatic cancer. Distal pancreatectomy was performed after neoadjuvant chemotherapy and radiotherapy. The pancreatic mass was diagnosed as Type B3 thymoma metastasis. Thirteen months after surgery for the pancreatic lesion, the patient underwent resection of the bilateral lung metastases. CLINICAL DISCUSSION: To the best of our knowledge, only four cases of metastatic thymic tumors in the pancreas have been reported. All patients who underwent surgical resection for pancreatic metastasis survived for >6 months including our case. CONCLUSION: In cases of thymic tumors with metastasis to extra-thoracic organs, complete resection of the metastatic lesions can contribute to prolonged survival.
  • 10℃保存により24時間の全肺虚血時間においても良好な経過をとった両側肺葉移植の一例
    新垣 雅人, 稲毛 輝長, 川島 光明, 谷口 大輔, 石綿 司, 加藤 達哉, 安福 和弘, Keshavjee Shaf, Cypel Marcelo
    移植, 57, 4, 396, 396, (一社)日本移植学会, Apr. 2023
    Japanese
  • A novel edge-marking method in pleural covering with video-assisted thoracic surgery.
    Aki Fujiwara-Kuroda, Yasuhiro Hida, Hideki Ujiie, Kichizo Kaga, Tatsuya Kato
    Interdisciplinary cardiovascular and thoracic surgery, 36, 3, 02 Mar. 2023, [International Magazine]
    English, Scientific journal, Total pleural covering is implemented to reinforce the visceral pleura with surgical sheets. It has been adopted for diffuse cystic lung diseases such as lymphangioleiomyomatosis to prevent pneumothorax and has achieved good results. The procedure is technically demanding, because it is difficult to cover the entire visceral pleura without disarrangement and jamming of surgical sheets, especially during thoracoscopic surgery, where grasping of a wrong site might happen when unfolding the sheets. Herein, we report a technique to cover the entire pleura with dotted line folded sheets to ease the thoracoscopic procedure. We found that the use of this marking method made the procedure easier, with just a little ingenuity, because marking the edges of sheets with dashed lines clarifies the site that should be grasped, thus preventing the incidence of grasping the wrong part of the sheet. Pleural covering with dotted line folded surgical sheets is a useful method for reduced port thoracoscopic surgery.
  • 医学生、研修医を対象とした医学教育とメディカルイラストの利用　　　　　　　　　　　　　　　
    加賀 基知三, 藤原 晶, 山崎 雅久, 千葉 龍平, 野村 俊介, 武藤 潤, 氏家 秀樹, 新垣 雅人, 加藤 達哉
    日本メディカルイラストレーション学会学術集会・総会, 7回, O, 3, 日本メディカルイラストレーション学会, Mar. 2023
    Japanese
  • 胸膜孤立性線維性腫瘍に合併したDoege-potter症候群の一例　　　　　　　　　　　　　　　
    村本 朋之, 中川 純一, 常田 慧徳, 高橋 文也, 木村 理奈, 西岡 典子, 坂本 圭太, 加藤 扶美, 氏家 秀樹, 加藤 達哉, 大藤 悠理, 亀田 啓, 中村 昭伸, 若林 健人, 松野 吉宏, 工藤 與亮
    北海道放射線医学雑誌, 3, 28, 32, (NPO)メディカルイメージラボ, Mar. 2023
    Japanese
  • Repeated photodynamic therapy mediates the abscopal effect through multiple innate and adaptive immune responses with and without immune checkpoint therapy.
    Jenny Lou, Masato Aragaki, Nicholas Bernards, Tess Chee, Alexander Gregor, Yoshihisa Hiraishi, Tsukasa Ishiwata, Chelsea Leung, Lili Ding, Shinsuke Kitazawa, Takamasa Koga, Yuki Sata, Hiroyuki Ogawa, Juan Chen, Tatsuya Kato, Kazuhiro Yasufuku, Gang Zheng
    Biomaterials, 292, 121918, 121918, Jan. 2023, [International Magazine]
    English, Scientific journal, In combination with immune checkpoint inhibitors, photodynamic therapy can induce robust immune responses capable of preventing local tumor recurrence and delaying the growth of distant, untreated disease (ie. the abscopal effect). Previously, we found that repeated photodynamic therapy (R-PDT) using porphyrin lipoprotein (PLP) as a photosensitizer, without the addition of an immune checkpoint inhibitor, can induce the abscopal effect. To understand why PLP mediated R-PDT alone can induce the abscopal effect, and how the addition of an immune checkpoint inhibitor can further strengthen the abscopal effect, we investigated the broader immune mechanisms facilitated by R-PDT and combination R-PDT + anti-PD-1 monoclonal antibody (αPD-1) in a highly aggressive, subcutaneous AE17-OVA mesothelioma dual tumor-bearing C57BL/6 mice. We found a 46.64-fold and 61.33-fold increase in interleukin-6 (IL-6) after R-PDT and combination R-PDT + αPD-1 relative to PBS respectively, suggesting broad innate immune activation. There was a greater propensity for antigen presentation in the spleen and distal, non-irradiated tumor draining lymph nodes, as dendritic cells and macrophages had increased expression of MHC class II, CD80, and CD86, after R-PDT and combination R-PDT + αPD-1. Concurrently, there was a shift in the proportions of CD4+ T cell subsets in the spleen, and an increase in the frequency of CD8+ T cells in the distal, non-irradiated tumor draining lymph nodes. While R-PDT had an acceptable safety profile, combination R-PDT + αPD-1 induced 1.26-fold higher serum potassium and 1.33-fold phosphorus, suggestive of mild laboratory tumor lysis syndrome. Histology revealed an absence of gross inflammation in critical organs after R-PDT and combination R-PDT + αPD-1 relative to PBS-treated mice. Taken together, our findings shed light on how the abscopal effect can be induced by PDT and strengthened by combination R-PDT + αPD-1, and suggests minimal toxicities after R-PDT.
  • 腹臥位・人工気胸下での胸腔内剥離が有用であった巨大縦隔内甲状腺腫の1例　　　　　　　　　　　　　　　
    武藤 潤, 加納 里志, 山崎 雅久, 千葉 龍平, 野村 俊介, 藤原 晶, 氏家 秀樹, 樋田 泰浩, 加賀 基知三, 本間 明宏, 加藤 達哉
    日本臨床外科学会雑誌, 83, 12, 2119, 2119, 日本臨床外科学会, Dec. 2022
    Japanese
  • 胸部単純エックス線写真読影の教材としてのデジタルイラスト
    加賀 基知三, 藤原 晶, 長島 諒太, 野村 俊介, 千葉 龍平, 田畑 佑希子, 氏家 秀樹, 加藤 達哉, 樋田 泰浩
    日本メディカルイラストレーション学会雑誌, 4, 1, 12, 12, 日本メディカルイラストレーション学会, Dec. 2022
    Japanese
  • 胸部単純エックス線写真読影の教材としてのデジタルイラスト　　　　　　　　　　　　　　　
    加賀 基知三, 藤原 晶, 長島 諒太, 野村 俊介, 千葉 龍平, 田畑 佑希子, 氏家 秀樹, 加藤 達哉, 樋田 泰浩
    日本メディカルイラストレーション学会雑誌, 4, 1, 12, 12, 日本メディカルイラストレーション学会, Dec. 2022
    Japanese
  • 胸・腹腔鏡併用下に横隔膜縫縮術を施行した食道癌術後横隔膜弛緩症の1例
    武藤 潤, 山崎 雅久, 千葉 龍平, 野村 俊介, 高島 雄太, 藤原 晶, 氏家 秀樹, 村上 壮一, 倉島 庸, 海老原 裕磨, 七戸 俊明, 樋田 泰浩, 加賀 基知三, 平野 聡, 加藤 達哉
    気管支学, 44, 6, 457, 457, (NPO)日本呼吸器内視鏡学会, Nov. 2022
    Japanese
  • 胸・腹腔鏡併用下に横隔膜縫縮術を施行した食道癌術後横隔膜弛緩症の1例
    武藤 潤, 山崎 雅久, 千葉 龍平, 野村 俊介, 高島 雄太, 藤原 晶, 氏家 秀樹, 村上 壮一, 倉島 庸, 海老原 裕磨, 七戸 俊明, 樋田 泰浩, 加賀 基知三, 平野 聡, 加藤 達哉
    気管支学, 44, 6, 457, 457, (NPO)日本呼吸器内視鏡学会, Nov. 2022
    Japanese
  • Optimization of thrombolytic dose for treatment of pulmonary emboli using endobronchial ultrasound-guided transbronchial needle injection.
    Masato Aragaki, Terunaga Inage, Tsukasa Ishiwata, Alexander Gregor, Nicholas Bernards, Tatsuya Kato, Kazuhiro Yasufuku
    The Journal of thoracic and cardiovascular surgery, 165, 5, e210-e221, 14 Sep. 2022, [International Magazine]
    English, Scientific journal, OBJECTIVE: Severe pulmonary embolism is often managed with thrombolysis. We sought to determine whether endobronchial ultrasound (EBUS)-guided transbronchial thrombolysis remained effective at lower alteplase doses, with the goal of minimizing potential bleeding risk. METHODS: Yorkshire pigs were anesthetized and ventilated. Preformed autologous blood clots were administered into bilateral pulmonary arteries via EBUS-guided transbronchial injection. After documenting baseline clot sizes, alteplase was injected into the clots using a 25-gauge transbronchial needle and clot dissolution was monitored over 30 minutes. The study was performed in 2 phases. First, alteplase doses of 5 and 12.5 mg were evaluated. These results informed dose selection for the second phase. Results were compared with 25-mg dose data using EBUS from a previous study. RESULTS: In the first phase, 3 clots were evaluated. Distilled water, 5 mg, and 12.5 mg alteplase were administered. The dissolved clot volume (Vdis) and percentage clot volume loss (Rdis) were -10.9, 111.6, and 160.3 mm3, and -1.6%, 11.0%, and 59.3%, respectively. In the second phase, alteplase doses of 5, 10, and 15 mg were evaluated in 12 clots across 6 pigs. The Vdis were 247.5 mm3 (Rdis, 20.1%), 910.8 mm3 (Rdis, 80.9%), and 798.3 mm3 (Rdis, 76.0%) for 5, 10, and 15 mg alteplase, respectively. Remakably reduced performance was observed with 5 mg alteplase versus 10 mg (Vdis: P < .001, Rdis: P < .001), and 15 mg (Vdis: P = .004; Rdis: P < .001). No complications were observed. CONCLUSIONS: Alteplase doses ≥10 mg were optimal for EBUS-guided transbronchial thrombolysis. This technique might represent an effective alternative therapy for central pulmonary embolism.
  • Parietal pleural small holes found in patients with primary spontaneous pneumothorax associated with relatively mild chest wall flatness: a retrospective study.
    Haruhiko Shiiya, Akihiko Tanaka, Motoki Sakuraba, Hideki Ujiie, Tatsuya Kato
    Journal of thoracic disease, 14, 9, 3255, 3264, Sep. 2022, [International Magazine]
    English, Scientific journal, BACKGROUND: During surgery for spontaneous pneumothorax, parietal pleural small holes (PPSHs) are occasionally found around the apex of the intrapleural space; however, this has not been well recognized. Additionally, chest wall flatness is usually observed in patients with primary spontaneous pneumothorax (PSP) and PPSHs. This study aimed to investigate the prevalence of PPSH and evaluate the characteristics of patients with PPSH. We also investigated the degree of chest wall flatness in patients with PPSHs. METHODS: We retrospectively reviewed all patients who underwent thoracoscopic surgery for pneumothorax at our department between April 2014 and May 2021. A propensity-matched analysis was used to compare the characteristics of patients with and without PPSH. RESULTS: A total of 490 patients were enrolled in this study. PPSH was found in 45 of 297 (15.2%) patients with PSP and one of 193 (0.5%) patients with secondary pneumothorax. PSP was independently associated with the presence of PPSH after adjusting for age and sex [primary/secondary, odds ratio (OR) =34.3, 95% confidence interval (CI): 4.7-250.9; P<0.001]. Among patients with PSP, the flatness of the chest wall in patients with PPSH was not as severe as that in patients without PPSH {thoracic anteroposterior diameter (APDT) to transverse diameter (TDT) ratio; with PPSH: median =0.517 [interquartile range (IQR) =0.480-0.554] vs. without PPSH: median =0.487 (IQR =0.463-0.529; P=0.031)} after propensity score matching. CONCLUSIONS: PPSH is found in a non-negligible proportion of patients with PSP, and patients with PPSHs show a relatively mild flat chest among patients with PSP. Clinicians should be aware of PPSH, and further understanding of this condition may contribute to a better understanding of PSP.
  • A case report of video-assisted flap bronchoplasty for central type typical carcinoid
    Yuya Wada, Hideki Ujiie, Ryohei Chiba, Shunsuke Nomura, Aki Fujiwara-Kuroda, Kichizo Kaga, Satoru Wakasa, Tatsuya Kato
    VIDEO-ASSISTED THORACIC SURGERY, Aug. 2022
    English, Scientific journal
  • デジタルイラストで伝わる手術記録(オペレコ)を描こう　　　　　　　　　　　　　　　
    加賀 基知三, 藤原 晶, 山崎 雅久, 千葉 龍平, 野村 俊介, 武藤 潤, 氏家 秀樹, 樋田 泰浩, 加藤 達哉
    日本気胸・嚢胞性肺疾患学会雑誌, 22, 2, 94, 94, 日本気胸・嚢胞性肺疾患学会, Aug. 2022
    Japanese
  • びまん性肺疾患を有する気胸に対しての治療戦略 骨髄移植後の移植片対宿主病(GVHD)肺病変を背景とした気胸手術症例の検討　　　　　　　　　　　　　　　
    武藤 潤, 山崎 雅久, 千葉 龍平, 野村 俊介, 藤原 晶, 氏家 秀樹, 樋田 泰浩, 加賀 基知三, 加藤 達哉
    日本気胸・嚢胞性肺疾患学会雑誌, 22, 2, 107, 107, 日本気胸・嚢胞性肺疾患学会, Aug. 2022
    Japanese
  • A novel system for analyzing indocyanine green (ICG) fluorescence spectra enables deeper lung tumor localization during thoracoscopic surgery.
    Ryohei Chiba, Yuma Ebihara, Haruhiko Shiiya, Hideki Ujiie, Aki Fujiwara-Kuroda, Kichizo Kaga, Liming Li, Satoru Wakasa, Satoshi Hirano, Tatsuya Kato
    Journal of thoracic disease, 14, 8, 2943, 2952, Aug. 2022, [International Magazine]
    English, Scientific journal, Background: Palpation of tumors during thoracoscopic surgery remains difficult, and identification of deep-seated tumors may be impossible. This preclinical study investigated the usefulness of a novel indocyanine green (ICG) fluorescence spectroscopy system for tumor localization. Methods: ICG was diluted to 5.0×10-2 mg/mL in fetal bovine serum (FBS) and mixed with silicone resin to prepare pseudo-tumors. Sponges of different densities and a porcine lung were placed on top of the pseudo-tumors, which were examined using a novel fluorescence spectroscopy system and a near-infrared (NIR) camera. Spectra were measured for different sponge and lung thicknesses, and the lung spectra were measured during both inflation and deflation. Results: The fluorescence spectroscopy system was able to identify tumors at depths ≥15 mm, while the NIR system was not. The spectroscopy system also detected tumors at greater depths when the density of the intervening material was lower. Depending on the density and thickness of the intervening material, the system could detect spectra as deep as 40 mm for sponges and 30 mm for lungs. Conclusions: This new fluorescence spectroscopy system can be used to identify lung tumors up to a depth of 30 mm in experiments using pseudo-tumors and a porcine lung, which may aid in tumor identification during thoracoscopic surgery.
  • 気管支充填術および持続陰圧吸引療法が有効であった有瘻性膿胸の一例
    山崎 雅久, 氏家 秀樹, 野村 俊介, 千葉 龍平, 武藤 潤, 藤原 晶, 樋田 泰浩, 加賀 基知三, 三浦 瞬, 高島 雄太, 品川 尚文, 加藤 達哉
    小切開・鏡視外科学会雑誌, 13, 1, 58, 58, (NPO)小切開・鏡視外科学会, Jun. 2022
    Japanese
  • 気管支充填術および持続陰圧吸引療法が有効であった有瘻性膿胸の一例
    山崎 雅久, 氏家 秀樹, 野村 俊介, 千葉 龍平, 武藤 潤, 藤原 晶, 樋田 泰浩, 加賀 基知三, 三浦 瞬, 高島 雄太, 品川 尚文, 加藤 達哉
    小切開・鏡視外科学会雑誌, 13, 1, 58, 58, (NPO)小切開・鏡視外科学会, Jun. 2022
    Japanese
  • Presurgical assessment of flow variability in an azygos vein aneurysm using 4D-flow MRI.
    Takuya Ikushima, Hideki Ujiie, Satonori Tsuneta, Ryohei Chiba, Yukiko Tabata, Aki Fujiwara-Kuroda, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Tatsuya Kato
    General thoracic and cardiovascular surgery, 70, 7, 673, 676, 06 Apr. 2022, [Domestic magazines]
    English, Scientific journal, Azygos vein aneurysm (AVA) is necessary to prevent pulmonary embolism due to the outflow of a thrombus or rupture of the aneurysm. However, there is no established modality to assess the properties of AVA. Time-resolved three-dimensional phase-contrast magnetic resonance imaging (4D-flow MRI) has been used to examine the hemodynamics in various fields. We report a case of AVA to evaluate the flow variability and adhesions of surrounding tissues using 4D-flow MRI. The findings of the study suggested aneurysm turbulence and the absence of thrombi. The cine image, which showed a sliding wall synchronized to the heartbeat, indicated no adhesion to the superior vena cava. Based on these results, the thoracoscopic approach was deemed possible preoperatively. Thoracoscopic AVA resection was performed, and the postoperative course was uneventful. This study documented the utility of 4D-flow MRI for a detailed evaluation of AVA.
  • 新規胸腔鏡用蛍光スペクトル測定システムは深部肺腫瘍の同定を可能にする　　　　　　　　　　　　　　　
    千葉 龍平, 加藤 達哉, 海老原 裕磨, 氏家 秀樹, 田畑 佑希子, 藤原 晶, 樋田 泰浩, 加賀 基知三
    日本外科学会定期学術集会抄録集, 122回, SF, 5, (一社)日本外科学会, Apr. 2022
    Japanese
  • 新規胸腔鏡用蛍光スペクトル測定システムは深部肺腫瘍の同定を可能にする　　　　　　　　　　　　　　　
    千葉 龍平, 加藤 達哉, 海老原 裕磨, 氏家 秀樹, 田畑 佑希子, 藤原 晶, 樋田 泰浩, 加賀 基知三
    日本外科学会定期学術集会抄録集, 122回, SF, 5, (一社)日本外科学会, Apr. 2022
    Japanese
  • 3D-バーチャル・リアリティー(VR)システムを用いた、呼吸器外科ロボット手術トレーニング法の開発　　　　　　　　　　　　　　　
    氏家 秀樹, 幾島 拓也, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲
    日本外科学会定期学術集会抄録集, 122回, SF, 3, (一社)日本外科学会, Apr. 2022
    Japanese
  • Elective Uniportal Video-Assisted Thoracoscopic Lobectomy for Congenital Cystic Lung Disease in a 2-Year-Old Child Using One-Lung Ventilation
    Haruhiko Shiiya, Hideki Ujiie, Tatsuya Kato, Shohei Honda, Satoru Wakasa, Kichizo Kaga
    INDIAN JOURNAL OF SURGERY, Apr. 2022
    English, Scientific journal
  • Antibody responses induced by the BNT162b2 mRNA COVID-19 vaccine in healthcare workers in a single community hospital in Japan.
    Shinya Otsuka, Kei Hiraoka, Masato Suzuoki, Hideki Ujiie, Tatsuya Kato, Isao Yokota, Kazuya Yonezawa, Keiji Oguma, Nozomu Iwashiro, Mototsugu Kato, Masanori Ohara
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 28, 4, 539, 542, Apr. 2022, [International Magazine]
    English, Scientific journal, INTRODUCTION: The effectiveness of several vaccines against coronavirus disease (COVID-19) has been reported in the real-world setting. However, it is still unknown how long antibodies persist following vaccination and whether or not the persistence of antibodies has a protective effect against COVID-19. METHODS: Healthcare workers who had received two doses of the BNT162b2 mRNA COVID-19 vaccine were enrolled, and a single-center study was conducted at the National Hospital Organization Hakodate National Hospital. Serum samples from all participants were collected 13-21 weeks (median: 20 weeks) after the second dose of vaccination. The antibody titers were measured using an electrochemiluminescence immunoassay (Elecsys® Anti-SARS-CoV-2 S). Data on characteristics of the participants were gathered from patient records and interview sheets. RESULTS: A total of 401 participants, among whom 70.1% were women and the median age was 42 years, were evaluated in this study. None of the participants had a definite COVID-19 history, and all participants who received complete vaccination showed positive antibody titers. The antibody titer was observed to be higher in participants with younger age (p < 0.001) and those who were females (p = 0.028). Despite the higher risk of infection than that of the general public, no vaccinated staff developed breakthrough infections. CONCLUSIONS: This study demonstrates the significant contribution of the BNT162b2 vaccine in the acquisition of anti-SARS-CoV-2S antibodies; therefore, the general population should benefit from these two vaccine doses, which are expected to be protective for at least five months.
  • 胸部単純エックス線写真読影の教材としてのデジタルイラスト　　　　　　　　　　　　　　　
    加賀 基知三, 藤原 晶, 長島 諒太, 野村 俊介, 千葉 龍平, 田畑 佑希子, 氏家 秀樹, 加藤 達哉, 樋田 泰浩
    日本メディカルイラストレーション学会学術集会・総会, 6回, np20, np21, 日本メディカルイラストレーション学会, Mar. 2022
    Japanese
  • Cadaverを用いた高難度呼吸器外科手術手技トレーニングの取り組み　　　　　　　　　　　　　　　
    藤原 晶, 加藤 達哉, 幾島 拓也, 千葉 龍平, 田畑 佑希子, 氏家 秀樹, 樋田 泰浩, 加賀 基知三
    日本臨床外科学会雑誌, 83, 3, 598, 598, 日本臨床外科学会, Mar. 2022
    Japanese
  • 胸部単純エックス線写真読影の教材としてのデジタルイラスト　　　　　　　　　　　　　　　
    加賀 基知三, 藤原 晶, 長島 諒太, 野村 俊介, 千葉 龍平, 田畑 佑希子, 氏家 秀樹, 加藤 達哉, 樋田 泰浩
    日本メディカルイラストレーション学会学術集会・総会, 6回, np20, np21, 日本メディカルイラストレーション学会, Mar. 2022
    Japanese
  • Cadaverを用いた高難度呼吸器外科手術手技トレーニングの取り組み　　　　　　　　　　　　　　　
    藤原 晶, 加藤 達哉, 幾島 拓也, 千葉 龍平, 田畑 佑希子, 氏家 秀樹, 樋田 泰浩, 加賀 基知三
    日本臨床外科学会雑誌, 83, 3, 598, 598, 日本臨床外科学会, Mar. 2022
    Japanese
  • 切除を先行した巨大(>10cm)肺腫瘤の2症例　　　　　　　　　　　　　　　
    千葉 龍平, 加賀 基知三, 幾島 拓也, 田畑 佑希子, 藤原 晶, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 若狭 哲, 岡崎 ななせ, 若林 健人, 松野 吉宏
    肺癌, 62, 1, 72, 73, (NPO)日本肺癌学会, Feb. 2022
    Japanese
  • 切除を先行した巨大(>10cm)肺腫瘤の2症例　　　　　　　　　　　　　　　
    千葉 龍平, 加賀 基知三, 幾島 拓也, 田畑 佑希子, 藤原 晶, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 若狭 哲, 岡崎 ななせ, 若林 健人, 松野 吉宏
    肺癌, 62, 1, 72, 73, (NPO)日本肺癌学会, Feb. 2022
    Japanese
  • 難治性肺瘻をどう取り扱うか 肺切除後難治性肺瘻の治療戦略　　　　　　　　　　　　　　　
    加賀 基知三, 樋田 泰浩, 加藤 達哉, 藤原 晶, 氏家 秀樹, 田畑 佑希子, 野村 俊介, 千葉 龍平, 幾島 拓也, 若狭 哲
    日本内視鏡外科学会雑誌, 26, 7, WS32, 3, (一社)日本内視鏡外科学会, Dec. 2021
    Japanese
  • 難治性肺瘻をどう取り扱うか 肺切除後難治性肺瘻の治療戦略　　　　　　　　　　　　　　　
    加賀 基知三, 樋田 泰浩, 加藤 達哉, 藤原 晶, 氏家 秀樹, 田畑 佑希子, 野村 俊介, 千葉 龍平, 幾島 拓也, 若狭 哲
    日本内視鏡外科学会雑誌, 26, 7, WS32, 3, (一社)日本内視鏡外科学会, Dec. 2021
    Japanese
  • 有瘻性膿胸に対し気管支充填術と持続陰圧吸引療法を併用した2症例
    田畑 佑希子, 加藤 達哉, 大塚 慎也, 幾島 拓也, 千葉 龍平, 藤原 晶, 氏家 秀樹, 樋田 泰浩, 品川 尚文, 有里 仁希, 高島 雄太, 加賀 基知三, 若狭 哲
    気管支学, 43, 6, 689, 689, (NPO)日本呼吸器内視鏡学会, Nov. 2021
    Japanese
  • 未来のための今 胸部外科医育成のための新たなる挑戦 3D-バーチャル・リアリティー(VR)システムを用いた、呼吸器外科手術トレーニング法の開発　　　　　　　　　　　　　　　
    氏家 秀樹, 幾島 拓也, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲
    日本胸部外科学会定期学術集会, 74回, SP5, 3, (一社)日本胸部外科学会, Oct. 2021
    Japanese
  • 奇静脈瘤の伸展評価における4D-Flow MRIの有用性　　　　　　　　　　　　　　　
    幾島 拓也, 氏家 秀樹, 加藤 達哉, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲
    日本胸部外科学会定期学術集会, 74回, LOD19, 5, (一社)日本胸部外科学会, Oct. 2021
    Japanese
  • バーチャル・リアリティー(VR)システムを用いた,ロボット外科手術シミュレーション法の開発
    氏家 秀樹, 幾島 拓也, 千葉 龍平, 野村 俊介, 田畑 佑希子, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲
    肺癌, 61, 6, 613, 613, (NPO)日本肺癌学会, Oct. 2021
    Japanese
  • バーチャル・リアリティー(VR)システムを用いた,ロボット外科手術シミュレーション法の開発　　　　　　　　　　　　　　　
    氏家 秀樹, 幾島 拓也, 千葉 龍平, 野村 俊介, 田畑 佑希子, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲
    肺癌, 61, 6, 613, 613, (NPO)日本肺癌学会, Oct. 2021
    Japanese
  • Surgical treatment for tracheal stent prolapse in a patient with blunt tracheal trauma.
    Shinya Otsuka, Tatsuya Kato, Hideki Ujiie, Aki Fujiwara-Kuroda, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Yuta Takashima, Naofumi Shinagawa
    General thoracic and cardiovascular surgery, 69, 12, 1589, 1592, 28 Sep. 2021, [Peer-reviewed], [Domestic magazines]
    English, Scientific journal, Blunt tracheal injury is a rare but life-threatening condition. Several indications for treatment have been reported. Conservative treatment (i.e., stenting) can be performed when the patient is clinically stable or has medical contraindications to surgical treatment. Although some studies have reported the use of tracheal stents as treatment for iatrogenic injury and blunt trauma, the efficacy of these stents is unknown. Herein, we report a case of emergency tracheoplasty for the management of tracheal stent prolapse in a patient with blunt tracheobronchial trauma. This report highlights the necessity of being cautious about the migration and prolapse of tracheal stents, which can more frequently occur in blunt trauma than in malignant stenosis or iatrogenic injury. Due to the limitations of non-surgical treatments, early surgical intervention may be lifesaving.
  • Elevated serum CYFRA 21-1 level as a diagnostic marker for thymic carcinoma.
    Haruhiko Shiiya, Hideki Ujiie, Yasuhiro Hida, Tatsuya Kato, Kichizo Kaga, Satoru Wakasa, Eiki Kikuchi, Naofumi Shinagawa, Kazufumi Okada, Yoichi M Ito, Yoshihiro Matsuno
    Thoracic cancer, 12, 21, 2933, 2942, 27 Sep. 2021, [Peer-reviewed], [International Magazine]
    English, Scientific journal, BACKGROUND: No useful tumor markers have been identified for the diagnosis of thymic carcinomas. Serum cytokeratin 19 fragment, measured using the CYFRA 21-1 immunoassay, is used as a tumor marker for squamous cell carcinomas in various malignant tumors. Here, we evaluated the value of CYFRA 21-1 in diagnosing thymic carcinoma. METHODS: We retrospectively reviewed 94 patients with pathological diagnoses of thymic carcinoma or thymoma (32 and 62 patients, respectively) who were referred to our departments between January 2000 and March 2019. Primary outcomes included tumor marker levels and their diagnostic accuracy. RESULTS: Patients with thymic carcinoma were significantly more likely to be male (thymic carcinoma, 68.8%; thymoma, 40.3%; p = 0.02), have an advanced TNM stage (p < 0.01), and a significantly higher CYFRA 21-1 level than those with thymoma (thymic carcinoma: median = 4.2 ng/ml; interquartile range [IQR] = 2.1-6.1 ng/ml vs. thymoma: median = 1.2 ng/ml; IQR = 0.9-1.7 ng/ml; p < 0.01). Receiver operating characteristic curves demonstrated that the area under the curve for CYFRA 21-1 to distinguish thymic carcinoma from thymoma was 0.86 (95% confidence interval [CI]: 0.74-0.93; cutoff = 2.7 ng/ml; sensitivity = 68.8%; specificity = 95.2%). Multivariable analysis demonstrated that CYFRA 21-1 (odds ratio = 25.6; 95% CI: 4.6-141.6; p < 0.01) was an independent predictor for thymic carcinoma after adjusting for TNM stage. CONCLUSIONS: Serum CYFRA 21-1 level may help in diagnosing thymic carcinoma.
  • Intralobar pulmonary sequestration associated with left main coronary artery obstruction and mitral regurgitation.
    Yusuke Motohashi, Tatsuya Kato, Nobuyasu Kato, Masato Aragaki, Aki Fujiwara-Kuroda, Tsuyoshi Tachibana, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa
    General thoracic and cardiovascular surgery, 69, 12, 1575, 1579, 21 Sep. 2021, [Peer-reviewed], [Corresponding author], [Domestic magazines]
    English, Scientific journal, A 4-year-old boy with left intralobar pulmonary sequestration associated with left main coronary artery obstruction (LMCAO) and severe mitral regurgitation (MR) was admitted to our hospital. Since the patient presented with dyskinesia of the cardiac apex and increased left ventricular end-diastolic volume (LVEDV), left main coronary artery reconstruction and mitral annuloplasty were performed. The enlargement of the left ventricle was improved after sequential surgeries. There was a risk of deterioration of MR and regrowth of LVEDV due to shunt blood flow; therefore, left lower lobectomy and aberrant artery division were performed. This is a very rare case of a patient with pulmonary sequestration associated with LMCAO and severe MR.
  • A Novel Treatment of Widespread Empyema Necessitatis.
    Shinya Otsuka, Hideki Ujiie, Kosuke Ishikawa, Takahiro Miura, Satoru Wakasa, Tatsuya Kato
    The Annals of thoracic surgery, 112, 6, e471, 04 Sep. 2021, [Peer-reviewed], [Corresponding author], [International Magazine]
    English, Scientific journal
  • 胎児治療を施行したCongenital pulmonary airway malformation(CPAM)の患児に対し日齢9で完全胸腔鏡下右上葉切除術を施行した一例　　　　　　　　　　　　　　　
    幾島 拓也, 氏家 秀樹, 加藤 達哉, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 本多 昌平
    日本気胸・嚢胞性肺疾患学会雑誌, 21, 2, 113, 113, 日本気胸・嚢胞性肺疾患学会, Sep. 2021
    Japanese
  • 肝移植後にPleuroparenchymal fibroelastosis(PPFE)合併肺癌を発症した一例　　　　　　　　　　　　　　　
    大塚 慎也, 加藤 達哉, 氏家 秀樹, 椎谷 洋彦, 加賀 基知三, 若狭 哲, 中村 順一, 中久保 祥, 木村 孔一, 渡辺 正明, 嶋村 剛, 岡崎 ななせ, 松野 吉宏, 田中 敏
    移植, 56, 総会臨時, P2, 7, (一社)日本移植学会, Sep. 2021
    Japanese
  • Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery.
    Akihiro Sasaki, Tatsuya Kato, Hideki Ujiie, Satoru Wakasa, Setsuyuki Otake, Keisuke Kikuchi, Koichi Ohno
    Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 28, 6, 448, 452, 16 Jul. 2021, [Peer-reviewed], [Domestic magazines]
    English, Scientific journal, INTRODUCTION: Stiff-person syndrome (SPS) is a rare autoimmune neurological disorder. Paraneoplastic SPS associated with malignant tumors such as thymoma occurs in approximately 5% of all SPS cases. We present a rare case of thymoma accompanied by SPS successfully treated using surgery. PRESENTATION OF CASE: A 26-year-old woman presented with lower limbs convulsions and gait disturbance and complained of leg pain. Cerebrospinal fluid and blood test results showed a high level of anti-glutamic acid decarboxylase (GAD) antibodies. Computed tomography showed anterior mediastinal tumor suggestive of a thymoma. She underwent extended thymectomy, and her symptoms gradually improved after surgery. No evidence of recurrent thymoma and SPS has been observed over 44 months. CONCLUSION: Surgical treatment would be effective for patients with SPS and thymoma.
  • Rare Diagnosis of a Multilobular Pulmonary Mass.
    Yoshinobu Watabe, Hideki Ujiie, Yoshihiro Matsuno, Hideaki Fukui, Aki Fujiwara-Kuroda, Tatsuya Kato, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa
    Chest, 160, 1, e63-e67, Jul. 2021, [Peer-reviewed], [International Magazine]
    English, Scientific journal, CASE PRESENTATION: A 57-year-old woman was admitted to our hospital for an abnormal chest shadow found during routine chest radiography. She had no respiratory symptoms. Her medical history included dyslipidemia, and her surgical history included conization for cervical cancer at age 38 years. She was a social drinker and ex-smoker of approximately 10 cigarettes per day (from ages 20 to 30 years); she denied recreational drug use.
  • Prediction of Pulmonary Embolism Following Resection of Pulmonary Infarction: A Case Series.
    Hiroshi Yamasaki, Hideki Ujiie, Tatsuya Kato, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Yoshihiro Matsuno
    Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 27, 6, 371, 379, 14 May 2021, [Peer-reviewed], [Corresponding author], [Domestic magazines]
    English, Scientific journal, PURPOSE: Pulmonary nodules suspected to be cancerous are rarely diagnosed as pulmonary infarction (PI). This study examined the clinical, radiological, and laboratory data in cases diagnosed with PI to determine their potential utility as preoperative diagnostic markers. We also assessed factors affecting the postoperative course. METHODS: A total of 603 cases of peripheral pulmonary nodules undiagnosed preoperatively were resected at Hokkaido University Hospital from 2012 to 2019. Of these, we reviewed cases with a postoperative diagnosis of PI. We investigated clinical symptoms, preoperative laboratory data, radiological characteristics, and postoperative complications. RESULTS: Four patients (0.7%) were diagnosed with PI. All patients had a smoking history. One patient received systemic steroid administration, and none had predisposing factors for thrombosis. One case showed chronologically increased nodule size. Three cases showed weak uptake of 18F-fluorodeoxyglucose. One patient with preoperative high D-dimer levels developed a massive pulmonary embolism (PE) in the postoperative chronic phase and was treated with anticoagulants. CONCLUSIONS: Preoperative diagnosis of PI is difficult, and we could not exclude lung cancer. However, if a patient diagnosed with PI has a high D-dimer level, we recommend postoperative physical examination for deep venous thrombosis. Prophylactic anticoagulation therapy should be considered to avoid fatal PE.
  • COVID-19に対する、北海道大学の取り組み　　　　　　　　　　　　　　　
    氏家 秀樹, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲, 石黒 信久, 豊嶋 崇徳
    日本呼吸器外科学会雑誌, 35, 3, SP2, 3, (NPO)日本呼吸器外科学会, May 2021
    Japanese
  • 小児に対するReduced port VATS　　　　　　　　　　　　　　　
    加賀 基知三, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 氏家 秀樹, 藤原 晶, 加藤 達哉, 樋田 泰浩, 若狭 哲
    日本呼吸器外科学会雑誌, 35, 3, SP4, 6, (NPO)日本呼吸器外科学会, May 2021
    Japanese
  • 呼吸器外科におけるトランスレーショナルリサーチの最前線 ctDNAを用いた肺癌術後のMinimal residual diseaseモニタリングの有用性　　　　　　　　　　　　　　　
    加藤 達哉, Low Siew-Kee, 清谷 一馬, 林 理絵, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 祐輔
    日本呼吸器外科学会雑誌, 35, 3, PD1, 5, (NPO)日本呼吸器外科学会, May 2021
    Japanese
  • 気管支充填術と分離陰圧閉鎖療法を併用した治療戦略　　　　　　　　　　　　　　　
    大塚 慎也, 加藤 達哉, 千葉 龍平, 椎谷 洋彦, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 三浦 隆洋, 石川 耕資
    日本呼吸器外科学会雑誌, 35, 3, O14, 3, (NPO)日本呼吸器外科学会, May 2021
    Japanese
  • 大動脈弓部トンネリング法による効果的なドレーン留置法　　　　　　　　　　　　　　　
    藤原 晶, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 加賀 基知三
    日本呼吸器外科学会雑誌, 35, 3, MO16, 5, (NPO)日本呼吸器外科学会, May 2021
    Japanese
  • 当院でのUniportal VATS導入経験　　　　　　　　　　　　　　　
    藤原 晶, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 加賀 基知三
    日本呼吸器外科学会雑誌, 35, 3, MO54, 4, (NPO)日本呼吸器外科学会, May 2021
    Japanese
  • 大動脈弓部トンネリング法による効果的なドレーン留置法　　　　　　　　　　　　　　　
    藤原 晶, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 加賀 基知三
    日本呼吸器外科学会雑誌, 35, 3, MO16, 5, (NPO)日本呼吸器外科学会, May 2021
    Japanese
  • 当院でのUniportal VATS導入経験　　　　　　　　　　　　　　　
    藤原 晶, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 加賀 基知三
    日本呼吸器外科学会雑誌, 35, 3, MO54, 4, (NPO)日本呼吸器外科学会, May 2021
    Japanese
  • COVID-19に対する、北海道大学の取り組み　　　　　　　　　　　　　　　
    氏家 秀樹, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲, 石黒 信久, 豊嶋 崇徳
    日本呼吸器外科学会雑誌, 35, 3, SP2, 3, (NPO)日本呼吸器外科学会, May 2021
    Japanese
  • 小児に対するReduced port VATS　　　　　　　　　　　　　　　
    加賀 基知三, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 氏家 秀樹, 藤原 晶, 加藤 達哉, 樋田 泰浩, 若狭 哲
    日本呼吸器外科学会雑誌, 35, 3, SP4, 6, (NPO)日本呼吸器外科学会, May 2021
    Japanese
  • 呼吸器外科におけるトランスレーショナルリサーチの最前線 ctDNAを用いた肺癌術後のMinimal residual diseaseモニタリングの有用性　　　　　　　　　　　　　　　
    加藤 達哉, Low Siew-Kee, 清谷 一馬, 林 理絵, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 祐輔
    日本呼吸器外科学会雑誌, 35, 3, PD1, 5, (NPO)日本呼吸器外科学会, May 2021
    Japanese
  • 気管支充填術と分離陰圧閉鎖療法を併用した治療戦略　　　　　　　　　　　　　　　
    大塚 慎也, 加藤 達哉, 千葉 龍平, 椎谷 洋彦, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 三浦 隆洋, 石川 耕資
    日本呼吸器外科学会雑誌, 35, 3, O14, 3, (NPO)日本呼吸器外科学会, May 2021
    Japanese
  • Feasibility of limited resection for peripheral small-sized non-small cell lung cancer: a retrospective single-center-based study.
    Masato Aragaki, Yasuhiro Hida, Tatsuya Kato, Aki Fujiwara-Kuroda, Kichizo Kaga, Satoru Wakasa
    Journal of cancer research and clinical oncology, 147, 5, 1519, 1527, May 2021, [Peer-reviewed], [International Magazine]
    English, Scientific journal, PURPOSE: This study aimed to establish new criteria for limited resection of non-small cell lung cancer (NSCLC) based on computed tomography findings and maximum standardized uptake value (SUVmax). METHODS: Between December 2007 and December 2015, 611 patients underwent lung cancer surgery; of these, 70 with cT1aN0M0 who underwent limited resection were enrolled. Criteria for undergoing intentional limited resection (ILR) were (1) tumor ground-glass opacity (GGO) ratio of ≥ 0.75 and (2) tumor SUVmax ≤ 1.5. Patients who met criteria (1) and (2) underwent partial resection, and those who only met criteria (2) underwent segmentectomy as ILR. The control group was subjected to limited surgery without meeting the criteria. RESULTS: Overall, 45 and 25 patients who met the criteria were included in the ILR and control groups, respectively. In the ILR group, 13 patients underwent partial resection, and 32 underwent segmentectomy; in the control group, 18 patients underwent partial resection and 7 underwent segmentectomy. According to our criteria, no relapsed cases occurred in the ILR group, although six patients showed recurrence of lung cancer in the control group. The 5-year overall survival (OS) rates in the ILR and control groups were 100% and 67.7%, respectively, and the relapse-free survival (RFS) rates were 100% and 61.6%, respectively. The log-rank test showed that this difference was statistically significant (OS: P < 0.0001, RFS: P < 0.0001). CONCLUSIONS: SUVmax may serve as a predictive marker of recurrence to determine the treatment strategy for patients with NSCLC. Patients with low GGO ratio and low SUVmax may be cured by limited resection.
  • 通常採血管を用いたctDNA測定による肺癌術後モニタリングは術後早期再発検出に有用である　　　　　　　　　　　　　　　
    加藤 達哉, Low Siew-Kee, 清谷 一馬, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 祐輔
    日本外科学会定期学術集会抄録集, 121回, SF, 2, (一社)日本外科学会, Apr. 2021
    Japanese
  • 通常採血管を用いたctDNA測定による肺癌術後モニタリングは術後早期再発検出に有用である　　　　　　　　　　　　　　　
    加藤 達哉, Low Siew-Kee, 清谷 一馬, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 祐輔
    日本外科学会定期学術集会抄録集, 121回, SF, 2, (一社)日本外科学会, Apr. 2021
    Japanese
  • Pneumatosis Intestinalis After Living Donor Lung Transplantation Associated With Alpha-Glucosidase Inhibitor Treatment: A Case Report.
    Shinya Otsuka, Hideki Ujiie, Tatsuya Kato, Haruhiko Shiiya, Aki Fujiwara-Kuroda, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Rei Inoue, Yasuaki Iimura
    Transplantation proceedings, 53, 4, 1379, 1381, 09 Mar. 2021, [Peer-reviewed], [Corresponding author], [International Magazine]
    English, Scientific journal, INTRODUCTION: Pneumatosis intestinalis (PI) is a rare but critical condition in which gas is found in the bowel wall. Although organ transplant recipients have an increased PI risk because of long-term immunosuppression, alpha-glucosidase inhibitors (α-GI), a standard diabetes therapy, often contribute to PI. However, little is known about the postorgan transplantation relationship between PI and α-GI. To the best of our knowledge, this is the first reported case of PI in a lung transplant recipient treated with α-GI. CASE REPORT: A 59-year-old man underwent hybrid (living-donor and cadaveric) lung transplantation (LTx). The patient was treated with prednisolone and tacrolimus as immunosuppressive therapy and α-GI for diabetes for 4 years. He developed asymptomatic PI 1031 days after transplantation without any acute abdominal finding. After excluding other possible causes of PI, his PI was attributed to α-GI. The suspected α-GI was immediately withdrawn. The patient was managed conservatively with bowel rest and oxygen therapy. After 11 days of α-GI discontinuation, PI improved, and the patient completely recovered. CONCLUSION: Physicians should keep this rare adverse drug reaction in mind when prescribing α-GI, particularly in patients with diabetes after organ transplantation and including LTx. The management strategy for asymptomatic PI caused by α-GI is the immediate discontinuation of α-GI therapy, followed by conservative management initiation.
  • 小児におけるニードルスコープを用いたReduced Port video assisted thoracoscopic surgery(RPVATS)(Reduced Port video assisted thoracoscopic surgery(RPVATS) using needle scope in children)　　　　　　　　　　　　　　　
    Kaga Kichizo, Hida Yasuhiro, Kato Tatsuya, Kuroda Fujiwara Akira, Shiina Nobuyuki, Ujiie Hideki, Sasaki Akihiro, Yamasaki Hiroshi
    日本内視鏡外科学会雑誌, 25, 7, OS82, 7, (一社)日本内視鏡外科学会, Mar. 2021
    English
  • 肺メディカルコンサルタント業務の肺移植外科医以外への委嘱の展望
    樋田 泰浩, 加賀 基知三, 加藤 達哉, 藤原 晶, 椎名 伸行, 氏家 秀樹, 佐々木 明洋, 山崎 洋, 大岡 智学
    移植, 55, 4, 504, 504, (一社)日本移植学会, Mar. 2021
    Japanese
  • A novel Tn antigen epitope-recognizing antibody for MUC1 predicts clinical outcome in patients with primary lung adenocarcinoma.
    Tatsuya Kato, Hideki Ujiie, Kanako C Hatanaka, Ayae Nange, Asami Okumura, Kaho Tsubame, Kentato Naruchi, Masaharu Sato, Kichizo Kaga, Yoshihiro Matsuno, Satoru Wakasa, Yutaka Hatanaka
    Oncology letters, 21, 3, 202, 202, Mar. 2021, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
    English, Scientific journal, Mucin 1 (MUC1) expression is upregulated in multiple types of cancer, including lung cancer. However, the conventional anti-MUC1 antibody is not useful for the differentiation of malignant lung tumors and benign lesions due to its limited specificity. Our previous study screened a novel epitope-defined antibody against cancer-associated sugar chain structures that specifically recognizes the MUC1 Tn antigen (MUC1-Tn ED Ab). In the present study, its potential utility as a diagnostic marker and therapeutic tool for lung adenocarcinoma (ADC) was examined. Immunohistochemical analysis of a lung ADC tissue microarray was performed using the MUC1-Tn ED Ab (clone SN-102), and the results were compared with those of another clone and commercially available MUC1 antibodies. The association between positive immunoreactivity of SN-102 and clinicopathologic factors was analyzed. Furthermore, the association between MUC1-Tn expression and epithelial-mesenchymal transition markers and radiological characteristics was analyzed. Moderate or high MUC1-Tn expression (MUC1-Tn-H) was observed in 138 (78.9%) of the 175 lung ADC cases. MUC1-Tn-H was associated with male sex, cigarette smoking, tumor extension, pleural invasion, and higher preoperative serum carcinoembryonic antigen and cytokeratin 19 fragment levels. Tumors with MUC1-Tn-H had higher consolidation/tumor ratios according to computed tomography and greater uptakes of 18F-fluorodeoxyglucose. A total of 46 (26.9%) of the tumors had mesenchymal features, and MUC1-Tn positivity was higher in the mesenchymal group than in the epithelial and intermediate groups (P<0.01 and P<0.01, respectively). Patients with tumors exhibiting MUC1-Tn-H had significantly shorter 5-year overall and disease-free survival times (P=0.011 and P<0.001, respectively). Additionally, MUC1-Tn-H was identified as an independent prognostic factor in multivariate analysis (P=0.024). MUC1-Tn is specific for lung cancer cells and can improve diagnostic capabilities. Additionally, it may be a potential therapeutic target in lung ADC.
  • 血気胸を発症したPleuroparenchymal fibroelastosis(PPFE)合併肺癌の1切除例
    大塚 慎也, 加藤 達哉, 佐々木 明洋, 山崎 洋, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 順一, 篠崎 鮎香, 中久保 祥, 木村 孔一, 渡辺 正明, 岡崎 ななせ, 松野 吉宏
    肺癌, 61, 1, 67, 67, (NPO)日本肺癌学会, Feb. 2021
    Japanese
  • 神経線維腫症I型に肺腺癌、内頸動静脈瘻を合併した1例
    横山 誓也, 氏家 秀樹, 加藤 達哉, 大塚 慎也, 佐々木 明洋, 山崎 洋, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 松野 吉宏, 今井 陽子
    肺癌, 61, 1, 67, 68, (NPO)日本肺癌学会, Feb. 2021
    Japanese
  • 血気胸を発症したPleuroparenchymal fibroelastosis(PPFE)合併肺癌の1切除例
    大塚 慎也, 加藤 達哉, 佐々木 明洋, 山崎 洋, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 順一, 篠崎 鮎香, 中久保 祥, 木村 孔一, 渡辺 正明, 岡崎 ななせ, 松野 吉宏
    肺癌, 61, 1, 67, 67, (NPO)日本肺癌学会, Feb. 2021
    Japanese
  • 神経線維腫症I型に肺腺癌、内頸動静脈瘻を合併した1例
    横山 誓也, 氏家 秀樹, 加藤 達哉, 大塚 慎也, 佐々木 明洋, 山崎 洋, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 松野 吉宏, 今井 陽子
    肺癌, 61, 1, 67, 68, (NPO)日本肺癌学会, Feb. 2021
    Japanese
  • Intraoperative real-time hemodynamics in intralobar pulmonary sequestration using indocyanine green and near-infrared thoracoscopy.
    Yusuke Motohashi, Tatsuya Kato, Masato Aragaki, Aki Fujiwara-Kuroda, Yasuhiro Hida, Satoru Wakasa, Kichizo Kaga
    General thoracic and cardiovascular surgery, 69, 2, 383, 387, Feb. 2021, [Peer-reviewed], [Corresponding author], [Domestic magazines]
    English, Scientific journal, A 33-year-old man with left pulmonary sequestration was admitted to our hospital. We planned left basilar segmentectomy to preserve the lung function, using indocyanine green (ICG) and near-infrared thoracoscopy. The intravenous (IV) administration of ICG (0.1 mg/kg) showed the distribution of fluorescence from the aberrant arteries, blood flow blockage from the aberrant arteries after they were divided, and the superior-basal boundary after the pulmonary artery and vein were divided. In adult patients with intralobar pulmonary sequestration, ICG and near-infrared thoracoscopic techniques are useful to confirm abnormal hemodynamics and demonstrate a safe and successful basilar segmentectomy.
  • Developing a virtual reality simulation system for preoperative planning of thoracoscopic thoracic surgery.
    Hideki Ujiie, Aogu Yamaguchi, Alexander Gregor, Harley Chan, Tatsuya Kato, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Chad Eitel, Tod R Clapp, Kazuhiro Yasufuku
    Journal of thoracic disease, 13, 2, 778, 783, Feb. 2021, [Peer-reviewed], [International Magazine]
    English, Scientific journal, Background: Video-assisted thoracoscopic surgery (VATS) has become a standard approach for the treatment of lung cancer. However, its minimally invasive nature limits the field of view and reduces tactile feedback. These limitations make it vital that surgeons thoroughly familiarize themselves with the patient's anatomy preoperatively. We have developed a virtual reality (VR) surgical navigation system using head-mounted displays (HMD). The aim of this study was to investigate the potential utility of this VR simulation system in both preoperative planning and intraoperative assistance, including support during thoracoscopic sublobar resection. Methods: Three-dimensional (3D) polygon data derived from preoperative computed tomography data was loaded into BananaVision software developed at Colorado State University and displayed on an HMD. An interactive 3D reconstruction image was created, in which all the pulmonary structures could be individually imaged. Preoperative resection simulations were performed with patient-individualized reconstructed 3D images. Results: The 3D anatomic structure of pulmonary vessels and a clear vision into the space between the lesion and adjacent tissues were successfully appreciated during preoperative simulation. Surgeons could easily evaluate the real patient's anatomy in preoperative simulations to improve the accuracy and safety of actual surgery. The VR software and HMD allowed surgeons to visualize and interact with real patient data in true 3D providing a unique perspective. Conclusions: This initial experience suggests that a VR simulation with HMD facilitated preoperative simulation. Routine imaging modalities combined with VR systems could substantially improve preoperative planning and contribute to the safety and accuracy of anatomic resection.
  • Primary pulmonary lymphoepithelioma-like carcinoma with positive expression of Epstein-Barr virus and PD-L1: A case report.
    Akihiro Sasaki, Tatsuya Kato, Hideki Ujiie, Yasushi Cho, Masaaki Sato, Mitsuhito Kaji
    International journal of surgery case reports, 79, 431, 435, Feb. 2021, [Peer-reviewed], [Corresponding author], [International Magazine]
    English, INTRODUCTION AND IMPORTANCE: Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare type of non-small cell lung cancer (NSCLC) that is classified as a subtype of unclassified carcinoma by the WHO. LELC is usually associated with Epstein-Barr virus (EBV) infection. LELC has often been observed in Southeast Asia; however, it is extremely rare in Japan. CASE PRESENTATION: A 60-year-old Japanese woman presented with an abnormal shadow in the left lung on chest radiography. Chest computed tomography showed a nodule located between the lingular and basal anteromedial segments. A blood test suggested an existing EBV infection, and LELC was suspected preoperatively in the transbronchial lung biopsy. She underwent a lingular and basal bi-segmentectomy. The EBV-encoded small ribonucleic acid in-situ hybridization (EBER-ISH) was positive, and she was diagnosed with LELC. Moreover, programmed death-ligand 1 (PD-L1) expression was moderately positive. No recurrence was observed for 30 months. CLINICAL DISCUSSION: Although LELC has been reported as a low-grade malignancy with a good prognosis, the frequency of PD-L1 expression in LELC seems to be higher than that in other NSCLCs. Moreover, it has been reported that LELC patients with high PD-L1 expression are likely to have early recurrence/metastasis and poor prognosis. CONCLUSION: An investigation of PD-L1 expression for LELC would be useful considering the benefit of PD-1/PD-L1 blockade in patients with pulmonary LELC with high PD-L1 expression. The present case is the first report of LELC with positive expression of EBER-ISH and PD-L1 in Japan.
  • Successful lung transplantation from lungs procured 12 hours after withdrawal of life-sustaining therapy: Changing the paradigm of controlled DCD donors?
    Laura L Donahoe, Tatsuya Kato, Andrew Healey, Thomas K Waddell, Jodie Heffren, Caitlin Mills, Maureen Meade, Diana Hallett, Shaf Keshavjee, Marcelo Cypel
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 40, 9, 1020, 1021, 23 Jan. 2021, [Peer-reviewed], [Lead author], ［Internationally co-authored］, [International Magazine]
    English
  • 降下性壊死性縦隔炎に対する大動脈弓部トンネリングによる左上縦隔ドレナージ
    藤原 晶, 大塚 慎也, 山崎 洋, 佐々木 明洋, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 加賀 基知三
    日本外科感染症学会雑誌, 17, 5, 482, 482, (一社)日本外科感染症学会, Oct. 2020
    Japanese
  • 肺移植患者における超音波気管支鏡の安全性および有効性の検討
    氏家 秀樹, 加藤 達哉, 稲毛 輝長, 石綿 司, 新垣 雅人, 樋田 泰浩, 加賀 基知三, 若狭 哲, Keshavjee Shaf, Yasufuku Kazuhiro
    移植, 55, 総会臨時, 383, 383, (一社)日本移植学会, Oct. 2020
    Japanese
  • 巨大粘液栓を伴った肺粘表皮癌の1例
    高橋 桂, 品川 尚文, 加藤 達哉, 高橋 宏典, 國崎 守, 樋田 泰浩, 加賀 基知三, 土井 和尚, 松野 吉宏, 今野 哲
    気管支学, 42, 5, 441, 447, (NPO)日本呼吸器内視鏡学会, Sep. 2020
    Japanese
  • Preoperative identification of clinicopathological prognostic factors for relapse-free survival in clinical N1 non-small cell lung cancer: a retrospective single center-based study.
    Masato Aragaki, Tatsuya Kato, Aki Fujiwara-Kuroda, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa
    Journal of cardiothoracic surgery, 15, 1, 229, 229, 28 Aug. 2020, [Peer-reviewed], [International Magazine]
    English, Scientific journal, BACKGROUND: Given the difficulty in preoperatively diagnosing lymph node metastasis, patients with Stage I-III non-small cell lung cancer (NSCLC) are likely to be included in the clinical N1 (cN1) group. However, better treatment options might be selected through further stratification. This study aimed to identify preoperative clinicopathological prognostic and stratification factors for patients with cN1 NSCLC. METHODS: This retrospective study evaluated 60 patients who were diagnosed with NSCLC during 2004-2014. Clinical nodal status had been evaluated using routine chest computed tomography (CT) and/or positron emission tomography (PET). To avoid biasing the fluorodeoxyglucose uptake values based on inter-institution or inter-model differences, we used only two PET systems (one PET system and one PET/CT system). Relapse-free survival (RFS) and overall survival (OS) were the primary study outcomes. The maximum standardized uptake value (SUVmax) was calculated for each tumor and categorized as low or high based on the median value. Patient sex, age, histology, tumor size, and tumor markers were also assessed. RESULTS: Poor OS was associated with older age (P = 0.0159) and high SUVmax values (P = 0.0142). Poor RFS was associated with positive carcinoembryonic antigen (CEA) expression (P = 0.0035) and high SUVmax values (P = 0.015). Multivariate analyses confirmed that poor OS was independently predicted by older age (hazard ratio [HR] = 2.751, confidence interval [CI]: 1.300-5.822; P = 0.0081) and high SUVmax values (HR = 5.121, 95% CI: 1.759-14.910; P = 0.0027). Furthermore, poor RFS was independently predicted by positive CEA expression (HR = 2.376, 95% CI: 1.056-5.348; P = 0.0366) and high SUVmax values (HR = 2.789, 95% CI: 1.042-7.458; P = 0.0410). The primary tumor's SUVmax value was also an independent prognostic factor for both OS and RFS. CONCLUSIONS: For patients with cN1 NSCLC, preoperative prognosis and stratification might be performed based on CEA expression, age, and the primary tumor's SUVmax value. To enhance the prognostic value of the primary tumor's SUVmax value, minimizing bias between facilities and models could lead to a more accurate prognostication.
  • 非触知肺病変に対するVATS ハイブリッド手術室での切除断端のマーキング、切除、確認法(MaRCH)(VATS for an unpalpable lung tumor, Marking, Resection and Confirmation of the surgical margin at the Hybrid operating room(MaRCH))　　　　　　　　　　　　　　　
    Hida Yasuhiro, Kaga Kichizo, Kato Tatsuya, Fujiwara Aki, Shiina Nobuyuki, Ujiie Hideki, Sasaki Akihiro, Yamasaki Hiroshi
    日本呼吸器外科学会雑誌, 34, 3, IS2, 1, (一社)日本呼吸器外科学会, Aug. 2020
    English
  • イメージガイド下センチネルリンパ節マッピングのためのマルチモーダルなナノスケール薬(A multi-modal nanoscale agent for image-guided sentinel lymph node mapping)　　　　　　　　　　　　　　　
    Ujiie Hideki, Chan Harley, Gregor Alexander, Motooka Yamato, Inage Terunaga, Aragaki Masato, Kato Tatsuya, Hida Yasuhiro, Kaga Kichizo, Waddell Thomas K, Keshavjee Shaf, Yasufuku Kazuhiro
    日本呼吸器外科学会雑誌, 34, 3, IS2, 2, (一社)日本呼吸器外科学会, Aug. 2020
    English
  • MUC1がん特異的糖鎖抗原は肺腺癌の有力な新規診断マーカーかつ予後因子となりうる　　　　　　　　　　　　　　　
    加藤 達哉, 畑中 佳奈子, 燕 果歩, 成地 健太郎, 佐藤 正治, 樋田 泰浩, 松野 吉宏, 畑中 豊, 加賀 基知三
    日本外科学会定期学術集会抄録集, 120回, DP, 3, (一社)日本外科学会, Aug. 2020
    Japanese
  • 非触知肺病変に対するVATS ハイブリッド手術室での切除断端の作成、切除、確認法(MaRCH)(VATS for an unpalpable lung tumor, Marking, Resection and Confirmation of the surgical margin at the Hybrid operating room(MaRCH))　　　　　　　　　　　　　　　
    Hida Yasuhiro, Kaga Kichizo, Kato Tatsuya, Fujiwara Aki, Shiina Nobuyuki, Ujiie Hideki, Sasaki Akihiro, Yamasaki Hiroshi
    日本呼吸器外科学会雑誌, 34, 3, IS2, 1, (NPO)日本呼吸器外科学会, Aug. 2020
    English
  • イメージガイド下センチネルリンパ節マッピングのためのマルチモーダルなナノスケール薬(A multi-modal nanoscale agent for image-guided sentinel lymph node mapping)　　　　　　　　　　　　　　　
    Ujiie Hideki, Chan Harley, Gregor Alexander, Motooka Yamato, Inage Terunaga, Aragaki Masato, Kato Tatsuya, Hida Yasuhiro, Kaga Kichizo, Waddell Thomas K, Keshavjee Shaf, Yasufuku Kazuhiro
    日本呼吸器外科学会雑誌, 34, 3, IS2, 2, (NPO)日本呼吸器外科学会, Aug. 2020
    English
  • 両側横隔神経、左反回神経切除、左浅深頸部・腋窩リンパ節、中葉肺転移摘除を行ったIV期胸腺カルチノイドの1例　　　　　　　　　　　　　　　
    樋田 泰浩, 加賀 基知三, 加藤 達哉, 藤原 晶, 椎名 伸行, 氏家 秀樹, 佐々木 明洋, 山崎 洋
    日本呼吸器外科学会雑誌, 34, 3, SP3, 3, (NPO)日本呼吸器外科学会, Aug. 2020
    Japanese
  • ドライバー遺伝子陽性c-stage IV肺癌患者に対する外科手術の意義　　　　　　　　　　　　　　　
    加藤 達哉, 椎名 伸行, 藤原 晶, 氏家 秀樹, 佐々木 明洋, 山崎 洋, 樋田 泰浩, 加賀 基知三
    日本呼吸器外科学会雑誌, 34, 3, RO10, 7, (NPO)日本呼吸器外科学会, Aug. 2020
    Japanese
  • 二窓法および細径光学視管を用いた一窓法によるReduced port surgeryと将来の展望　　　　　　　　　　　　　　　
    加賀 基知三, 樋田 泰浩, 加藤 達哉, 藤原 晶, 氏家 秀樹, 佐々木 明洋, 山崎 洋
    日本呼吸器外科学会雑誌, 34, 3, O36, 5, (NPO)日本呼吸器外科学会, Aug. 2020
    Japanese
  • 単孔式胸腔鏡への移行を念頭に置いた胸腔鏡手術の分類とトレーニング法　　　　　　　　　　　　　　　
    樋田 泰浩, 加賀 基知三, 加藤 達哉, 藤原 晶, 椎名 伸行, 氏家 秀樹, 佐々木 明洋, 山崎 洋
    日本呼吸器外科学会雑誌, 34, 3, MO2, 1, (NPO)日本呼吸器外科学会, Aug. 2020
    Japanese
  • 4D-CTにより術前に右房浸潤の有無を予測できた胸腺腫瘍の一例　　　　　　　　　　　　　　　
    山崎 洋, 樋田 泰浩, 佐々木 明洋, 椎名 伸行, 藤原 晶, 氏家 秀樹, 加藤 達哉, 加賀 基知三
    日本呼吸器外科学会雑誌, 34, 3, MO26, 5, (NPO)日本呼吸器外科学会, Aug. 2020
    Japanese
  • 手術可能な肺がんに対する術後のモニタリングとしてのctDNA測定の有用性の検証　　　　　　　　　　　　　　　
    加藤 達哉, Low Siew-Kee, 清谷 一馬, 中村 透, 藤原 晶, 氏家 秀樹, 椎名 伸行, 樋田 泰浩, 加賀 基知三, 中村 祐輔
    日本呼吸器外科学会雑誌, 34, 3, MO27, 2, (NPO)日本呼吸器外科学会, Aug. 2020
    Japanese
  • 手術介入を要した胸部外傷の検討　　　　　　　　　　　　　　　
    佐々木 明洋, 山崎 洋, 椎名 伸行, 氏家 秀樹, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三
    日本呼吸器外科学会雑誌, 34, 3, MO60, 9, (NPO)日本呼吸器外科学会, Aug. 2020
    Japanese
  • 出産を契機に生じた奇静脈瘤内血栓に対し緊急手術を施行した1例　　　　　　　　　　　　　　　
    椎名 伸行, 加藤 達哉, 佐々木 明洋, 山崎 洋, 藤原 晶, 氏家 秀樹, 樋田 泰浩, 福井 秀章, 松野 吉宏, 加賀 基知三
    日本呼吸器外科学会雑誌, 34, 3, MO64, 4, (NPO)日本呼吸器外科学会, Aug. 2020
    Japanese
  • 非典型的な先天性嚢胞性肺疾患　　　　　　　　　　　　　　　
    加賀 基知三, 大塚 慎也, 佐々木 明洋, 山崎 洋, 氏家 秀樹, 藤原 晶[黒田], 加藤 達哉, 樋田 泰浩, 若狭 哲
    日本気胸・嚢胞性肺疾患学会雑誌, 20, 1, 69, 69, 日本気胸・嚢胞性肺疾患学会, Aug. 2020
    Japanese
  • A Novel Insertion Technique for the Extra-Long Montgomery T-Tube in Patients with a Large Mediastinal Tumor.
    Tatsuya Kato, Aki Fujiwara-Kuroda, Nobuyuki Shiina, Masato Aragaki, Hideki Ujiie, Yasuhiro Hida, Kichizo Kaga
    Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 26, 5, 294, 297, 01 Aug. 2020, [Peer-reviewed], [Lead author, Corresponding author], [Domestic magazines]
    English, Scientific journal, The Montgomery T-tube is widely used to stent airway stenotic diseases. Conventional insertion methods can sometimes fail in the case of long-distance subglottic stenosis due to the flexibility of a T-tube made of silicon, which kinks when forced against resistance. Therefore, an alternative approach can assist in the insertion of an extra-long T-tube, especially when using a long proximal limb. We report herein the case of a patient with a large mediastinal tumor caused by neurofibromatosis type 1 in which airway obstruction was avoided through the use of a novel extra-long T-tube placement technique.
  • 智と技の伝承(鏡視外科手術トレーニングの将来像) ドライラボ、カダバーを用いた単孔式胸腔鏡手術(Uniportal VATS)トレーニングの経験
    藤原 晶, 大塚 慎也, 山崎 洋, 佐々木 明洋, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲
    小切開・鏡視外科学会雑誌, 11, 1, 38, 38, (NPO)小切開・鏡視外科学会, Jun. 2020
    Japanese
  • 先天性肺嚢胞性疾患に対する胸腔鏡手術の適応と成績
    加賀 基知三, 大塚 慎也, 佐々木 明洋, 山崎 洋, 氏家 秀樹, 藤原 晶[黒田], 加藤 達哉, 樋田 泰浩, 若狭 哲
    小切開・鏡視外科学会雑誌, 11, 1, 50, 50, (NPO)小切開・鏡視外科学会, Jun. 2020
    Japanese
  • 胸腔鏡下手術における下位肋間経路による新しい切除肺の創外摘出法(eXtraction of resecting specimens through the Lower INterCostal route(XLINC) method、XLINC)について
    佐々木 明洋, 大塚 慎也, 山崎 洋, 氏家 秀樹, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三
    小切開・鏡視外科学会雑誌, 11, 1, 58, 58, (NPO)小切開・鏡視外科学会, Jun. 2020
    Japanese
  • 大網弁の積極利用による膿胸の治療と予防
    樋田 泰浩, 加賀 基知三, 加藤 達哉, 藤原 晶, 椎名 伸行, 氏家 秀樹, 佐々木 明洋, 山崎 洋
    気管支学, 42, Suppl., S179, S179, (NPO)日本呼吸器内視鏡学会, Jun. 2020
    Japanese
  • 【小児の先天性嚢胞性肺疾患に対する胸腔鏡手術】
    加賀 基知三, 樋田 泰浩, 加藤 達哉, 藤原 晶[黒田], 椎名 伸行, 氏家 秀樹, 佐々木 明洋, 山崎 洋, 若狭 哲
    北海道外科雑誌, 65, 1, 2, 7, 北海道外科学会, Jun. 2020
    Japanese
  • Endobronchial ultrasound-guided radiofrequency ablation of lung tumors and mediastinal lymph nodes: a preclinical study in animal lung tumor and mediastinal adenopathy models.
    Yamato Motooka, Kosuke Fujino, Alexander Gregor, Nicholas Bernards, Harley Chan, Terunaga Inage, Hideki Ujiie, Tatsuya Kato, Tomonari Kinoshita, Tsukasa Ishiwata, Makoto Suzuki, Kazuhiro Yasufuku
    Seminars in thoracic and cardiovascular surgery, 10 Feb. 2020, [Peer-reviewed], [International Magazine]
    English, Radiofrequency ablation (RFA) can be a therapeutic option in medically inoperable lung cancer patients. In this study, we evaluated a prototype bipolar RFA device applicator that can be deployed from a standard endobronchial ultrasound (EBUS) bronchoscope to determine feasibility and histopathological analysis in animal models. Rabbit lung cancers were created by transbronchial injection of VX2 rabbit cancer cells. Once the tumors were developed, they were ablated transpleurally, under EBUS guidance using the prototype RFA device. The animals were then sacrificed for specimen resection. Pig inflammatory lung pseudo-tumors and lymphadenopathy were created by transbronchial injection of a talc paste and ablated transbronchially under EBUS guidance. Pigs were evaluated at five days, two weeks, and four weeks following ablation by bronchoscopy and cone-beam computed tomography before necropsy. Nicotinamide adenine dinucleotide hydrogen diaphorase staining was employed to measure the ablation area. Twenty-four VX2 rabbit tumors were ablated. The total ablated area ranged from 0.6 to 3.0 cm2 (mean: 1.8 cm2), corresponding to a total energy range of 1 to 6 kJ. Six pig lung pseudo-tumors and five mediastinal lymph nodes (LNs) were ablated. Adjacent airway ulceration was observed in three ablations of LNs. These airway complications resolved within four weeks of RFA without any treatment. There was no hemoptysis, air embolism, respiratory distress, or other serious complication noted. In these two animal models, we provide evidence that EBUS-guided bipolar RFA is feasible and histopathology shows that can ablate lung tumors and mediastinal lymph nodes under real-time ultrasound guidance.
  • Changes in cerebral oxygen saturation during one-lung ventilation determined using spatially resolved spectroscopy and contributing factors.
    Nobuhiro Tanaka, Ryoko Ito Katoh, Masataka Yamamoto, Koji Hoshino, Yuji Morimoto, Yoichi M Ito, Tatsuya Kato
    Journal of clinical anesthesia, 59, 99, 100, Feb. 2020, [Peer-reviewed], [International Magazine]
    English
  • A novel approach for the complete extraction of large tumours in video-assisted thoracoscopic surgery.
    Masato Aragaki, Kichizo Kaga, Yasuhiro Hida, Tatsuya Kato, Yoshiro Matsui
    Journal of minimal access surgery, 28 Jan. 2020, [Peer-reviewed], [International Magazine]
    English, Scientific journal, Background: Video-assisted thoracoscopic (VATS) lobectomy has recently become the standard for treating lung cancer. However, the complete removal of large tumours from the chest cavity is often difficult. Therefore, we developed a novel approach to extract large tumours from the wound without rib resection or fracture (the eXtraction of resected specimens through the Lower INterCostal route [XLINC] method). Subjects and Methods: In XLINC, a skin incision is made on the tenth intercostal space, and the resected lung tissue is extracted. This retrospective study included patients who underwent VATS lobectomy using XLINC in our institution from 2016 to 2018. As a control group, six patients who had undergone thoracotomy during VATS surgery due to a large tumour diameter were included in the conversion group. Results: Four men and six women (median age = 66 years, maximum median tumour diameter = 59 mm) were included in the study. The median length of the wound incision for XLINC was 4.5 (range: 4-8) cm. The median operative time was 183 min, and the estimated blood loss was 50 ml. Rib resection was not required, and no fractures were noted. The median length of hospital stay was 8 days. No patients developed major complications caused by XLINC. There were no significant differences, except in operation time and amount of blood loss, between the two groups. However, the XLINC group used fewer post-operative analgesics. Conclusion: Our report suggests that XLINC might be a simpler, less invasive procedure that could be used in patients with large tumours.
  • 肺移植患者における超音波気管支鏡の安全性および有効性の検討
    氏家 秀樹, 加藤 達哉, 稲毛 輝長, 石綿 司, 新垣 雅人, 樋田 泰浩, 加賀 基知三, 若狭 哲
    移植, 55, Supplement, 383_2, 383_2, 一般社団法人 日本移植学会, 2020
    Japanese, 目的 気管支腔内超音波検査法（EBUS）は低侵襲かつ高い診断能を有する検査手技である。本研究では、肺移植待機患者および移植後患者の経過中に、悪性腫瘍が疑われた肺・リンパ節病変に対するEBUSの有用性を検討した。方法 2008年～2018年までの間にEBUSガイド下経気道的肺生検 (EBUS-GS-TBB, EBUS-TBNA)が施行された肺移植後患者及び待機患者に対し後方視的検討を行った。結果 全28例に対してEBUS-TBNA：20例、EBUS-GS-TBB：8例 が施行された。肺移植術後患者19例の内訳は、移植後に肺腫瘤を認め悪性腫瘍が疑われた11例、肺門及び縦隔リンパ節腫大を認め移植後リンパ増殖性疾患(PTLD)が疑われた8例であった。全症例において確定診断が可能であり、重篤な合併症を認めなかった。診断の内訳は、原発性肺癌6例、PTLD 4例、感染性疾患3例、良性疾患6例であった。PTLDが疑われた8例中、4例（50%）がPTLDと診断され、肺悪性腫瘍が疑われた11例中、6例(55%)で肺悪性腫瘍の確定診断が可能であった。また、肺移植待機9例のうち、5例（56%）にて肺悪性腫瘍の確定診断に至り、治療方針が変更された。結論 移植待機中の末期慢性肺疾患症例及び肺移植術前後症例におけるEBUSは、肺病変及び縦隔肺門リンパ節に対する安全かつ高精度な質的診断が可能な検査法と考えられた。
  • 呼吸器外科におけるReduced port surgery 細径内視鏡を用いたreduced port thoracic surgery一窓法の適応と限界　　　　　　　　　　　　　　　
    樋田 泰浩, 加賀 基知三, 加藤 達哉, 藤原 晶, 椎名 伸行, 佐々木 明洋, 山崎 洋
    日本内視鏡外科学会雑誌, 24, 7, SY16, 1, (一社)日本内視鏡外科学会, Dec. 2019
    Japanese
  • 胸腔鏡困難症例に対するknack & pitfall 気管支断端被覆や大きな腫瘍の摘出を要する症例に対する胸腔鏡下肺葉切除　　　　　　　　　　　　　　　
    樋田 泰浩, 加賀 基知三, 加藤 達哉, 藤原 晶, 椎名 伸行, 佐々木 明洋, 山崎 洋
    日本内視鏡外科学会雑誌, 24, 7, WS25, 3, (一社)日本内視鏡外科学会, Dec. 2019
    Japanese
  • 北海道「地域」肺メディカルコンサルタントと脳死ドナーあたりの肺臓提供数の推移
    樋田 泰浩, 加藤 達哉, 藤原 晶, 椎名 伸行, 佐々木 明洋, 山崎 洋, 大岡 智学, 加賀 基知三
    移植, 54, 総会臨時, 211, 211, (一社)日本移植学会, Sep. 2019
    Japanese
  • Feasibility and safety of reduced-port video-assisted thoracoscopic surgery using a needle scope for pulmonary lobectomy- retrospective study.
    Masato Aragaki, Kichizo Kaga, Yasuhiro Hida, Tatsuya Kato, Yoshiro Matsui
    Annals of medicine and surgery (2012), 45, 70, 74, Sep. 2019, [Peer-reviewed], [International Magazine]
    English, Scientific journal, Background: This study aimed to determine the usefulness and limitations of videoassisted thoracoscopic (VATS) lobectomy using one-window and puncture method (1WPM). Methods: This study involved 14 patients who underwent lobectomy using the 1WPM at our institute from 2008 to 2017. Results: The study patients comprised of 3 men and 11 women with a median age of 10.5 years (range, 0-72 years). There were eight cases in children younger than 18 years old and the youngest patient was 9 days old. The diagnoses were congenital pulmonary cystic disease (n = 7), primary lung cancer (n = 4), metastatic lung tumor (n = 1), and others (n = 2). The 1WPM was successful in 9 of 14 patients (64.3%) and, in 5 cases (35.7%), needed conversion to either two-window method (TWM) using additional port (n = 3) or open thoracotomy (n = 2). The causes for conversion were need for additional bronchoplasty or lymph node dissection (n = 3), failure of one-lung ventilation (n = 1), and presence of a small thoracic cavity that made the procedure extremely difficult (n = 1). In the group that was successfully treated with 1WPM, the median values were as follows: operation time, 193 min (range, 112-480 min); blood loss, 0 ml (range, 0-90 ml); drainage duration, 1 day (range, 1-4 days); and postoperative hospital stay, 7 days (range, 4-13 days). Conclusions: Lobectomy by 1WPM can be safely performed and has good postoperative course and this procedure can be applicable and effective in small infants.
  • Lung cancer photothermal ablation by low-power near-infrared laser and topical injection of indocyanine green.
    Hirohashi K, Anayama T, Wada H, Nakajima T, Kato T, Keshavjee S, Orihashi K, Yasufuku K
    Interactive cardiovascular and thoracic surgery, Jul. 2019, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  • Downregulated expression of human leukocyte antigen class I heavy chain is associated with poor prognosis in non-small-cell lung cancer.
    Kazuomi Ichinokawa, Yoshitsugu Nakanishi, Yasuhiro Hida, Takahiro Tsuchikawa, Tatsuya Kato, Tomoo Itoh, Mitsuhito Kaji, Kichizo Kaga, Satoshi Hirano
    Oncology letters, 18, 1, 117, 126, Jul. 2019, [Peer-reviewed], [International Magazine]
    English, Scientific journal, The aim of this study was to clarify the association between expression of human leukocyte antigen (HLA) class I in non-small-cell lung cancer (NSCLC) cells and patient survival. To address this, immunohistochemical staining for HLA class I was performed on specimens from 111 patients with NSCLC, and overall survival curves were compared using the log-rank test. In addition, multivariate analyses were performed using Cox's proportional hazard model. The cases were divided into 5 classes based on the expression of HLA class I heavy chain and β2-microglobulin. The overall survival rate for patients with tumors lacking HLA class I heavy chain (30 cases; 27.0%) was significantly decreased. The multivariate analysis demonstrated that the absence of HLA class I heavy chain was an independent predictor of poor prognosis. There was a trend towards an unfavorable prognosis for patients whose tumors did not express β2-microglobulin (57 cases; 51.4%). Downregulation of HLA class I heavy chain expression was significantly associated with the downregulation of β2-microglobulin. Cases lacking HLA class I heavy chain as well as β2-microglobulin expression (23 cases; 20.7%) had a statistically significant unfavorable prognosis compared with other cases. The present findings demonstrate that the lack of HLA class I heavy chain expression in tumor cells is an independent prognostic factor for poor NSCLC survival, and is likely to exert an important influence on immune surveillance in patients.
  • 小児嚢胞性肺疾患に対する胸腔鏡下肺葉切除と手術時期の検討
    加賀 基知三, 本橋 雄介, 藤原 晶, 新垣 雅人, 加藤 達哉, 樋田 泰浩, 本多 昌平, 松居 喜郎
    小切開・鏡視外科学会雑誌, 10, 1, 54, 54, (NPO)小切開・鏡視外科学会, Jun. 2019
    Japanese
  • 肺移植未認定施設における肺移植トレーニングプログラムの有用性の検討 北海道での肺移植施設認定への取り組み
    加藤 達哉, 新垣 雅人, 長 靖, 道免 寛充, 樋田 泰浩, 七戸 俊明, 加賀 基知三, 平野 聡, 松居 喜郎
    北海道外科雑誌, 64, 1, 43, 50, 北海道外科学会, Jun. 2019, [Peer-reviewed]
    Japanese
  • 小児嚢胞性肺疾患に対する胸腔鏡下肺葉切除と手術時期の検討
    加賀 基知三, 本橋 雄介, 藤原 晶, 新垣 雅人, 加藤 達哉, 樋田 泰浩, 本多 昌平, 松居 喜郎
    小切開・鏡視外科学会雑誌, 10, 1, 54, 54, (NPO)小切開・鏡視外科学会, Jun. 2019
    Japanese
  • 左冠動脈閉鎖・僧帽弁閉鎖不全を合併した肺葉内肺分画症の1例　　　　　　　　　　　　　　　
    本橋 雄介, 藤原 晶, 新垣 雅人, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 新井 洋輔, 加藤 伸康, 橘 剛, 松居 喜郎
    日本臨床外科学会雑誌, 80, 5, 1029, 1029, 日本臨床外科学会, May 2019
    Japanese
  • 小児外科領域における真の低侵襲手術とは? 小児嚢胞性肺疾患に対する胸腔鏡下肺葉切除と手術時期の検討　　　　　　　　　　　　　　　
    加賀 基知三, 本橋 雄介, 藤原 晶, 新垣 雅人, 加藤 達哉, 樋田 泰浩, 本多 昌平, 松居 喜郎
    日本外科学会定期学術集会抄録集, 119回, WS, 4, (一社)日本外科学会, Apr. 2019
    English
  • ハイブリッド手術室における胸腔鏡下触知困難肺腫瘍部分切除のナビゲーションと切除肺のマージン確認(OS MaRCH法)　　　　　　　　　　　　　　　
    樋田 泰浩, 加賀 基知三, 加藤 達哉, 新垣 雅人, 藤原 晶, 本橋 雄介, 松居 喜郎
    日本外科学会定期学術集会抄録集, 119回, SF, 5, (一社)日本外科学会, Apr. 2019
    English
  • 肺癌に対する薬物療法の進歩と外科治療の役割 免疫チェックポイント阻害剤時代の根治的化学放射線療法後の肺切除の役割　　　　　　　　　　　　　　　
    樋田 泰浩, 加賀 基知三, 加藤 達哉, 新垣 雅人, 藤原 晶, 本橋 雄介, 松居 喜郎
    日本呼吸器外科学会雑誌, 33, 3, S, 2, (NPO)日本呼吸器外科学会, Apr. 2019
    Japanese
  • 異常血管の灌流領域の確認と区域間同定に赤外光胸腔鏡を用いた肺葉内肺分画症の一例　　　　　　　　　　　　　　　
    本橋 雄介, 加藤 達哉, 新垣 雅人, 藤原 晶, 樋田 泰浩, 加賀 基知三, 松居 喜郎
    日本呼吸器外科学会雑誌, 33, 3, V8, 1, (NPO)日本呼吸器外科学会, Apr. 2019
    Japanese
  • ハイブリッド手術室における肺腫瘍のナビゲーションと切除肺のマージン確認(OS MaRCH法)　　　　　　　　　　　　　　　
    樋田 泰浩, 加賀 基知三, 加藤 達哉, 新垣 雅人, 藤原 晶, 本橋 雄介, 松居 喜郎
    日本呼吸器外科学会雑誌, 33, 3, O10, 4, (NPO)日本呼吸器外科学会, Apr. 2019
    Japanese
  • 不全分葉間に発生した肺癌に対する胸腔鏡下複合区域切除における赤外光胸腔鏡の有用性　　　　　　　　　　　　　　　
    加藤 達哉, 新垣 雅人, 藤原 晶, 本橋 雄介, 樋田 泰浩, 福井 秀章, 松野 吉宏, 加賀 基知三, 松居 喜郎
    日本呼吸器外科学会雑誌, 33, 3, P57, 2, (NPO)日本呼吸器外科学会, Apr. 2019
    Japanese
  • Porphyrin-High-Density Lipoprotein: A Novel Photosensitizing Nanoparticle for Lung Cancer Therapy.
    Hideki Ujiie, Lili Ding, Rong Fan, Tatsuya Kato, Daiyoon Lee, Kosuke Fujino, Tomonari Kinoshita, Chang Young Lee, Thomas K Waddell, Shaf Keshavjee, Brian C Wilson, Gang Zheng, Juan Chen, Kazuhiro Yasufuku
    The Annals of thoracic surgery, 107, 2, 369, 377, Feb. 2019, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
    English, Scientific journal, BACKGROUND: We have developed ultrasmall porphyrin-high-density lipoprotein (HDL) nanoparticles (<20 nm), called "porphyrinHDL," that have a high density of porphyrin molecules and dissociate rapidly upon tumor cell accumulation to become fluorescent and photoactive. This is introduced as a novel activatable photosensitizer for image-guided photodynamic therapy (PDT). Here, we report the studies of these nanoparticles targeted to scavenger receptor class B type I (SR-BI) expressed on lung cancer cells as a first step toward development of a minimally invasive treatment for peripheral lung cancer and metastatic lymph nodes of advanced lung cancer. METHODS: The in vitro uptake of porphyrinHDL and the corresponding PDT efficacy were evaluated in both SR-BI-positive and SR-BI-negative lung cancer cell lines. A clinically relevant orthotopic lung cancer model in mice was used to examine fluorescence activation and quantification of uptake in tumor. In addition, we investigated the effect of porphyrinHDL-mediated PDT. RESULTS: PorphyrinHDL promoted proper intracellular uptake in the H460 human lung cancer cell line. When irradiated with a 671-nm PDT laser, porphyrinHDL produced significant therapeutic effectiveness in vitro. After systemic administration in mice with orthotopic lung cancer xenografts, porphyrinHDL demonstrated selective accumulation and photoactivation in tumor with significantly enhanced disease-to-normal tissue contrast. Moreover, porphyrinHDL-PDT significantly induced cell apoptosis in lung tumors (73.2%) without toxicity in normal tissues or damage to adjacent critical structures. CONCLUSIONS: SR-BI-targeted porphyrinHDL-mediated PDT of lung cancer is selective and effective in vitro and in vivo. These initial proof-of-principle studies suggest the potential of a "smart" PDT approach for highly selective tumor ablation.
  • Intraoperative Near-Infrared Fluorescence-Guided Peripheral Lung Tumor Localization in Rabbit Models.
    Hironobu Wada, Jinzi Zheng, Alexander Gregor, Kentaro Hirohashi, Hsin-Pei Hu, Priya Patel, Hideki Ujiie, Tatsuya Kato, Takashi Anayama, David A Jaffray, Kazuhiro Yasufuku
    The Annals of thoracic surgery, 107, 1, 248, 256, Jan. 2019, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
    English, Scientific journal, BACKGROUND: A novel liposomal nanoparticle, CF800, that co-encapsulates indocyanine green for near-infrared (NIR) imaging and iohexol for computed tomography (CT) imaging has shown preferential tumor accumulation after intravenous injection by the enhanced permeability and retention effect. We hypothesized that CF800-enhanced NIR imaging would facilitate intraoperative localization of small lung nodules. METHODS: A rabbit VX2 lung tumor model was implemented. CF800 was injected intravenously, followed by sequential CT acquisitions to track the biodistribution of CF800. Eleven rabbits were used for NIR fluorescence evaluation after thoracotomy at time points until 7 days after injection by using a NIR fluorescence thoracoscope in vivo. Organs of interests were removed for ex vivo analysis by using NIR imaging. Tumor-to-background (inflated lung) ratio was calculated and compared among the time points. RESULTS: Both CT and NIR imaging indicated enhanced accumulation of CF800 within the VX2 tumor. NIR image analysis revealed the highest tumor-to-background ratio on days 4 and 5. High background at day 2 and low tumor signal at day 7 prevented distinct demarcation. Metastatic pulmonary small nodules (less than 2 mm in diameter) were successfully visualized by NIR imaging on day 4. However, NIR signal penetration was limited, resulting in localization failure for the few tumors deep (>0 mm) to the lung surface. CONCLUSIONS: NIR image-guided localization of small lung nodules appears to be feasible under certain conditions. However, further refinement will be required to increase tumor signal intensity and to reduce background signal from normal lung parenchyma, which is at least in part a consequence of persistent CF800 in the vasculature.
  • 小児胸腔鏡手術-小児外科医と呼吸器外科医の立場から- 小児呼吸器疾患に対する胸腔鏡手術の現状と課題　　　　　　　　　　　　　　　
    新垣 雅人, 加賀 基知三, 樋田 泰浩, 加藤 達哉, 藤原 晶, 本橋 雄介, 本多 昌平, 松居 喜郎
    日本内視鏡外科学会雑誌, 23, 7, PD15, 4, (一社)日本内視鏡外科学会, Dec. 2018
    Japanese
  • Reduced Port VATSの短期および長期成績 二窓法および細径光学視管を用いた一窓法によるReduced port surgeryの実際と成績　　　　　　　　　　　　　　　
    加賀 基知三, 樋田 泰浩, 加藤 達哉, 新垣 雅人, 藤原 晶, 本橋 雄介, 松居 喜郎
    日本内視鏡外科学会雑誌, 23, 7, WS19, 3, (一社)日本内視鏡外科学会, Dec. 2018
    Japanese
  • 大学病院における胸腔鏡手術の教育体制　　　　　　　　　　　　　　　
    樋田 泰浩, 加賀 基知三, 加藤 達哉, 新垣 雅人, 藤原 晶
    日本内視鏡外科学会雑誌, 23, 7, OS104, 1, (一社)日本内視鏡外科学会, Dec. 2018
    Japanese
  • Preclinical investigation of folate receptor-targeted nanoparticles for photodynamic therapy of malignant pleural mesothelioma.
    Tatsuya Kato, Cheng S Jin, Daiyoon Lee, Hideki Ujiie, Kosuke Fujino, Hsin-Pei Hu, Hironobu Wada, Licun Wu, Juan Chen, Rober A Weersink, Hiromi Kanno, Yutaka Hatanaka, Kanako C Hatanaka, Kichizo Kaga, Yoshiro Matsui, Yoshihiro Matsuno, Marc De Perrot, Brian C Wilson, Gang Zheng, Kazuhiro Yasufuku
    International journal of oncology, 53, 5, 2034, 2046, Nov. 2018, [Peer-reviewed], [Lead author], ［Internationally co-authored］, [International Magazine]
    English, Scientific journal, Photodynamic therapy (PDT) following lung-sparing extended pleurectomy for malignant pleural mesothelioma (MPM) has been investigated as a potential means to kill residual microscopic cells. High expression levels of folate receptor 1 (FOLR1) have been reported in MPM; therefore, targeting FOLR1 has been considered a novel potential strategy. The present study developed FOLR1‑targeting porphyrin-lipid nanoparticles (folate-porphysomes, FP) for the treatment of PDT. Furthermore, inhibition of activated epidermal growth factor (EGFR)-associated survival pathways enhance PDT efficacy. In the present study, these approaches were combined; FP-based PDT was used together with an EGFR-tyrosine kinase inhibitor (EGFR-TKI). The frequency of FOLR1 and EGFR expression in MPM was analyzed using tissue microarrays. Confocal microscopy and a cell viability assay were performed to confirm the specificity of FOLR1‑targeting cellular uptake and photocytotoxicity in vitro. In vivo fluorescence activation and therapeutic efficacy were subsequently examined. The effects of EGFR-TKI were also assessed in vitro. The in vivo combined antitumor effect of EGFR-TKI and FP-PDT was then evaluated. The results revealed that FOLR1 and EGFR were expressed in 79 and 89% of MPM samples, respectively. In addition, intracellular uptake of FP corresponded well with FOLR1 expression. When MPM cells were incubated with FP and then irradiated at 671 nm, there was significant in vitro cell death, which was inhibited in the presence of free folic acid, thus suggesting the specificity of FPs. FOLR1 targeting resulted in disassembly of the porphysomes and subsequent fluorescence activation in intrathoracic disseminated MPM tumors, as demonstrated by ex vivo tissue imaging. FP-PDT resulted in significant cellular damage and apoptosis in vivo. Furthermore, the combination of pretreatment with EGFR-TKI and FP-PDT induced a marked improvement of treatment responses. In conclusion, FP-based PDT induced selective destruction of MPM cells based on FOLR1 targeting, and pretreatment with EGFR-TKI further enhanced the therapeutic response.
  • 非移植認定施設における肺移植手術シミュレーションの有用性
    加藤 達哉, 新垣 雅人, 樋田 泰浩, 千葉 龍平, 本橋 雄介, 道免 寛充, 長 靖, 加賀 基知三, 松居 喜郎
    移植, 53, 総会臨時, 472, 472, (一社)日本移植学会, Sep. 2018
    Japanese
  • Prognostic value of MAGEA4 in primary lung cancer depends on subcellular localization and p53 status.
    Aki Fujiwara-Kuroda, Tatsuya Kato, Takehiro Abiko, Takahiro Tsuchikawa, Noriaki Kyogoku, Masaomi Ichinokawa, Kimitaka Tanaka, Takehiro Noji, Yasuhiro Hida, Kichizo Kaga, Yoshiro Matsui, Hiroaki Ikeda, Shinichi Kageyama, Hiroshi Shiku, Satoshi Hirano
    International journal of oncology, 53, 2, 713, 724, Aug. 2018, [Peer-reviewed], [Corresponding author], [International Magazine]
    English, Scientific journal, Melanoma antigen family A4 (MAGEA4), a cancer/testis antigen, is overexpressed and is thus an immunotherapy target in various malignant tumors, including non-small cell lung cancer. However, whether MAGEA4 induces or inhibits the apoptosis of lung cancer cells remains controversial, as is its prognostic significance, particularly since there is no reliable method with which to detect MAGEA4 specifically. In this study, we optimized assay conditions to detect MAGEA4 based on cells transiently transfected with MAGEA genes, and found that MAGEA4 was expressed in four of eight non-small cell lung cancer cell lines, and in 25.4% of clinical lung cancer specimens. We also found that MAGEA4 overexpression decreased apoptosis, as measured by the levels of cleaved caspase-3 in stably transfected 293F cells. Notably, patients with nuclear MAGEA4, but not p53 expression exhibited a significantly poorer survival than those expressing both nuclear MAGEA4 and p53. Indeed, multivariate analysis identified nuclear MAGEA4 as an independent prognostic factor (P=0.0042), albeit only in the absence of p53. In this study, to the best of our knowledge, we are the first to demonstrate that the function and prognostic value of MAGEA4 depends on its subcellular localization and on the p53 status.
  • インドシアニングリーン蛍光胸腔鏡を用いた胸腔鏡下複数肺区域切除
    加藤 達哉, 新垣 雅人, 八木 優樹, 千葉 龍平, 樋田 泰浩, 加賀 基知三, 松井 喜郎
    小切開・鏡視外科学会雑誌, 9, 1, 22, 22, (NPO)小切開・鏡視外科学会, Jun. 2018
    Japanese
  • 小児・新生児に対するReduced Port VATSによる肺葉切除　　　　　　　　　　　　　　　
    加賀 基知三, 千葉 龍平, 八木 優樹, 久保田 玲子, 新垣 雅人, 加藤 達哉, 樋田 泰浩, 松居 喜郎
    日本呼吸器外科学会雑誌, 32, 3, O13, 1, (NPO)日本呼吸器外科学会, Apr. 2018
    Japanese
  • 触知困難肺腫瘍のone-stop solution、術中病変マーキングと切除肺のマージン確認(OS MaRCH法)　　　　　　　　　　　　　　　
    樋田 泰浩, 加賀 基知三, 加藤 達哉, 新垣 雅人, 八木 優樹, 千葉 龍平, 松居 喜郎
    日本呼吸器外科学会雑誌, 32, 3, O26, 2, (NPO)日本呼吸器外科学会, Apr. 2018
    Japanese
  • 巨大縦隔神経線維腫症に対して可及的切除とTチューブ挿入により気道狭窄を回避できた1例　　　　　　　　　　　　　　　
    加藤 達哉, 新垣 雅人, 八木 優樹, 千葉 龍平, 樋田 泰浩, 加賀 基知三, 松居 喜郎
    日本呼吸器外科学会雑誌, 32, 3, O32, 1, (NPO)日本呼吸器外科学会, Apr. 2018
    Japanese
  • 食道癌手術既往のある肺癌手術症例の検討　　　　　　　　　　　　　　　
    新垣 雅人, 加賀 基知三, 樋田 泰浩, 加藤 達哉, 八木 優樹, 千葉 龍平, 松居 喜郎
    日本呼吸器外科学会雑誌, 32, 3, P10, 6, (NPO)日本呼吸器外科学会, Apr. 2018
    Japanese
  • 胸腔鏡下手術における下位肋間経路による新しい切除臓器の創外摘出法(eXtraction method of resected specimen through the Lower INterCostal route-XLINC-)　　　　　　　　　　　　　　　
    新垣 雅人, 加賀 基知三, 樋田 泰浩, 加藤 達哉, 八木 優樹, 千葉 龍平, 松居 喜郎
    日本外科学会定期学術集会抄録集, 118回, 1796, 1796, (一社)日本外科学会, Apr. 2018
    Japanese
  • 胸腔鏡手術における切除肺の創外摘出法の工夫　　　　　　　　　　　　　　　
    千葉 龍平, 加賀 基知三, 樋田 泰浩, 加藤 達哉, 新垣 雅人, 久保田 玲子, 八木 優樹, 松居 喜郎
    日本臨床外科学会雑誌, 79, 3, 619, 620, 日本臨床外科学会, Mar. 2018
    Japanese
  • Personalized siRNA-Nanoparticle Systemic Therapy using Metastatic Lymph Node Specimens Obtained with EBUS-TBNA in Lung Cancer.
    Tatsuya Kato, Daiyoon Lee, Huang Huang, William Cruz, Hideki Ujiie, Kosuke Fujino, Hironobu Wada, Priya Patel, Hsin-Pei Hu, Kentaro Hirohashi, Takahiro Nakajima, Masaaki Sato, Mitsuhito Kaji, Kichizo Kaga, Yoshiro Matsui, Juan Chen, Gang Zheng, Kazuhiro Yasufuku
    Molecular cancer research : MCR, 16, 1, 47, 57, Jan. 2018, [Peer-reviewed], [Lead author], ［Internationally co-authored］, [International Magazine]
    English, Scientific journal, Inhibiting specific gene expression with siRNA provides a new therapeutic strategy to tackle many diseases at the molecular level. Recent strategies called high-density lipoprotein (HDL)-mimicking peptide-phospholipid nanoscaffold (HPPS) nanoparticles have been used to induce siRNAs-targeted delivery to scavenger receptor class B type I receptor (SCARB1)-expressing cancer cells with high efficiency. Here, eight ideal therapeutic target genes were identified for advanced lung cancer throughout the screenings using endobronchial ultrasonography-guided transbronchial needle aspiration (EBUS-TBNA) and the establishment of a personalized siRNA-nanoparticle therapy. The relevance of these genes was evaluated by means of siRNA experiments in cancer cell growth. To establish a therapeutic model, kinesin family member-11 (KIF11) was selected as a target gene. A total of 356 lung cancers were analyzed immunohistochemically for its clinicopathologic significance. The antitumor effect of HPPS-conjugated siRNA was evaluated in vivo using xenograft tumor models. Inhibition of gene expression for these targets effectively suppressed lung cancer cell growth. SCARB1 was highly expressed in a subset of tumors from the lung large-cell carcinoma (LCC) and small-cell lung cancer (SCLC) patients. High-level KIF11 expression was identified as an independent prognostic factor in LCC and squamous cell carcinoma (SqCC) patients. Finally, a conjugate of siRNA against KIF11 and HPPS nanoparticles induced downregulation of KIF11 expression and mediated dramatic inhibition of tumor growth in vivoImplications: This approach showed delivering personalized cancer-specific siRNAs via the appropriate nanocarrier may be a novel therapeutic option for patients with advanced lung cancer. Mol Cancer Res; 16(1); 47-57. ©2017 AACR.
  • 根治的化学放射線療法後再発・再燃肺癌に対するサルベージ手術と周術期合併症の予防　　　　　　　　　　　　　　　
    樋田 泰浩, 加賀 基知三, 加藤 達哉, 新垣 雅人, 久保田 玲子[中田], 八木 優樹, 千葉 龍平, 松居 喜郎
    肺癌, 57, 7, 917, 918, (NPO)日本肺癌学会, Dec. 2017
    Japanese
  • 外科的切除を行った縦隔脂肪肉腫の3症例　　　　　　　　　　　　　　　
    千葉 龍平, 加賀 基知三, 樋田 泰浩, 八木 優樹, 久保田 玲子, 新垣 雅人, 加藤 達哉, 松居 喜郎
    肺癌, 57, 7, 919, 919, (NPO)日本肺癌学会, Dec. 2017
    Japanese
  • Reduced port surgery・Single port VATS lobectomy:標準化できるのか?標準化するのか? 二窓法および細径光学視管を用いた一窓法によるReduced port surgery肺葉切除の適応　　　　　　　　　　　　　　　
    加賀 基知三, 樋田 泰浩, 加藤 達哉, 新垣 雅人, 千葉 龍平, 八木 優樹, 久保田 玲子, 松居 喜郎
    日本内視鏡外科学会雑誌, 22, 7, WS2, 2, (一社)日本内視鏡外科学会, Dec. 2017
    Japanese
  • 切除肺創外摘出法の工夫　　　　　　　　　　　　　　　
    新垣 雅人, 加賀 基知三, 樋田 泰浩, 加藤 達哉, 八木 優樹
    日本内視鏡外科学会雑誌, 22, 7, SF012, 03, (一社)日本内視鏡外科学会, Dec. 2017
    Japanese
  • 食道癌手術既往のある肺切除症例の検討
    新垣 雅人, 加賀 基知三, 樋田 泰浩, 加藤 達哉, 久保田 玲子[中田], 八木 優樹, 千葉 龍平, 松居 喜郎
    北海道外科雑誌, 62, 2, 182, 182, 北海道外科学会, Dec. 2017
    Japanese
  • Nanoparticle targeted folate receptor 1-enhanced photodynamic therapy for lung cancer.
    Tatsuya Kato, Cheng S Jin, Hideki Ujiie, Daiyoon Lee, Kosuke Fujino, Hironobu Wada, Hsin-Pei Hu, Robert A Weersink, Juan Chen, Mitsuhito Kaji, Kichizo Kaga, Yoshiro Matsui, Brian C Wilson, Gang Zheng, Kazuhiro Yasufuku
    Lung cancer (Amsterdam, Netherlands), 113, 59, 68, Nov. 2017, [Peer-reviewed], [Lead author], ［Internationally co-authored］, [International Magazine]
    English, Scientific journal, OBJECTIVE: Despite modest improvements, the prognosis of lung cancer patients has still remained poor and new treatment are urgently needed. Photodynamic therapy (PDT), the use of light-activated compounds (photosensitizers) is a treatment option but its use has been restricted to central airway lesions. Here, we report the use of novel porphyrin-lipid nanoparticles (porphysomes) targeted to folate receptor 1 (FOLR1) to enhance the efficacy and specificity of PDT that may translate into a minimally-invasive intervention for peripheral lung cancer and metastatic lymph nodes of advanced lung cancer. MATERIALS AND METHODS: The frequency of FOLR1 expression in primary lung cancer and metastatic lymph nodes was first analyzed by human tissue samples from surgery and endobronchial ultrasonography-guided transbronchial needle aspiration (EBUS-TBNA). Confocal fluorescence microscopy was then used to confirm the cellular uptake and fluorescence activation in lung cancer cells, and the photocytotoxicity was evaluated using a cell viability assay. In vivo fluorescence activation and quantification of uptake were investigated in mouse lung orthotopic tumor models, followed by the evaluation of in vivo PDT efficacy. RESULTS: FOLR1 was highly expressed in metastatic lymph node samples from patients with advanced lung cancer and was mainly expressed in lung adenocarcinomas in primary lung cancer. Expression of FOLR1 in lung cancer cell lines corresponded with the intracellular uptake of folate-porphysomes in vitro. When irradiated with a 671nm laser at a dose of 10J/cm2, folate-porphysomes showed marked therapeutic efficacy compared with untargeted porphysomes (28% vs. 83% and 24% vs. 99% cell viability in A549 and SBC5 lung cancer cells, respectively). Systemically-administered folate-porphysomes accumulated in lung tumors with significantly enhanced disease-to-normal tissue contrast. Folate-porphysomes mediated PDT successfully inhibited tumor cell proliferation and activated tumor cell apoptosis. CONCLUSION: Folate-porphysome based PDT shows promise in selectively ablating lung cancer based on FOLR1 expression in these preclinical models.
  • 肺動脈性肺高血圧症における肺移植後の早期死亡率に関連する術前肝機能マーカーに関する検討
    加藤 達哉, Donahoe Laura, 大石 久, 中島 大輔, 橋本 浩平, Azad Sassan, Cypel Marcelo, de Perrot Marc, Pierre Andrew, Yasufuku Kazuhiro, Waddell Thomas, Granton John, Singer Lianne G., 加賀 基知三, 樋田 泰浩, 松居 喜郎, Jee Shaf Keshav
    移植, 52, 2-3, 275, 275, (一社)日本移植学会, Sep. 2017
    Japanese
  • 先天性嚢胞性肺疾患に対する胸腔鏡下肺葉切除の適応と限界　　　　　　　　　　　　　　　
    加賀 基知三, 千葉 龍平, 八木 優樹, 久保田 玲子, 新垣 雅人, 加藤 達哉, 樋田 泰浩, 松居 喜郎
    日本気胸・嚢胞性肺疾患学会雑誌, 17, 2, 96, 96, 日本気胸・嚢胞性肺疾患学会, Aug. 2017
    Japanese
  • A novel minimally invasive near-infrared thoracoscopic localization technique of small pulmonary nodules: A phase I feasibility trial
    Hideki Ujiie, Tatsuya Kato, Hsin-pei Hu, Priya Patel, Hironobu Wada, Kosuke Fujino, Robert Weersink, Elsie Nguyen, Marcelo Cypel, Andrew Pierre, Marc de Perrot, Gail Darling, Thomas K. Waddell, Shaf Keshavjee, Kazuhiro Yasufuku
    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 154, 2, 702, 711, Aug. 2017, [Peer-reviewed], ［Internationally co-authored］
    English, Scientific journal
  • Overexpression of MAGEA2 has a prognostic significance and is a potential therapeutic target for patients with lung cancer
    Hideki Ujiie, Tatsuya Kato, Daiyoon Lee, Hsin-Pei Hu, Kosuke Fujino, Mitsuhito Kaji, Kichizo Kaga, Yoshiro Matsui, Kazuhiro Yasufuku
    INTERNATIONAL JOURNAL OF ONCOLOGY, 50, 6, 2154, 2170, Jun. 2017, [Peer-reviewed], ［Internationally co-authored］
    English, Scientific journal
  • Development of a novel ex vivo porcine laparoscopic Heller myotomy and Nissen fundoplication training model (Toronto lap-Nissen simulator)
    Hideki Ujiie, Tatsuya Kato, Hsin-Pei Hu, Patrycja Bauer, Priya Patel, Hironobu Wada, Daiyoon Lee, Kosuke Fujino, Colin Schieman, Andrew Pierre, Thomas K. Waddell, Shaf Keshavjee, Gail E. Darling, Kazuhiro Yasufuku
    JOURNAL OF THORACIC DISEASE, 9, 6, 1517, +, Jun. 2017, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
    English, Scientific journal
  • 肋骨弓下切開による摘出肺創外摘出法の工夫　　　　　　　　　　　　　　　
    新垣 雅人, 加賀 基知三, 樋田 泰浩, 加藤 達哉, 久保田 玲子, 八木 優樹, 千葉 龍平, 松居 喜郎
    小切開・鏡視外科学会雑誌, 8, 1, 43, 43, (NPO)小切開・鏡視外科学会, May 2017
    Japanese
  • Tronto general hospitalにおける小型肺結節に関する胸腔鏡を用いた新規位置特定法(A novel thoracoscopic localization technique of small pulmonary nodules at Toronto general hospital)　　　　　　　　　　　　　　　
    Ujiie Hideki, Kato Tatsuya, Fujino Kosuke, Igai Hitoshi, Waddell Thomas K., Keshavjee Shaf
    日本外科学会定期学術集会抄録集, 117回, SF, 1, (一社)日本外科学会, Apr. 2017
    English
  • First Evaluation of the New Thin Convex Probe Endobronchial Ultrasound Scope: A Human Ex Vivo Lung Study
    Priya Patel, Hironobu Wada, Hsin-Pei Hu, Kentaro Hirohashi, Tatsuya Kato, Hideki Ujiie, Jin Young Ahn, Daiyoon Lee, William Geddie, Kazuhiro Yasufuku
    ANNALS OF THORACIC SURGERY, 103, 4, 1158, 1164, Apr. 2017, [Peer-reviewed]
    English, Scientific journal
  • Evaluation of a New Ultrasound Thoracoscope for Localization of Lung Nodules in Ex Vivo Human Lungs
    Hideki Ujiie, Tatsuya Kato, Hsin-pei Hu, Suhaib Hasan, Priya Patel, Hironobu Wada, Daiyoon Lee, Kosuke Fujino, David M. Hwang, Marcelo Cypel, Marc de Perrot, Andrew Pierre, Gail Darling, Thomas K. Waddell, Shaf Keshavjee, Kazuhiro Yasufuku
    ANNALS OF THORACIC SURGERY, 103, 3, 926, 934, Mar. 2017, [Peer-reviewed]
    English, Scientific journal
  • Gene signature
    Hideki Ujiie, Daiyoon Lee, Tatsuya Kato, Kazuhiro Yasufuku
    Molecular Targeted Therapy of Lung Cancer, 279, 292, 01 Jan. 2017, [Peer-reviewed]
    In book
  • SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma
    Tatsuya Kato, Daiyoon Lee, Licun Wu, Priya Patel, Jin Young, Hironobu Wada, Hsin-Pei Hu, Hideki Ujiie, Mitsuhito Kaji, Satoshi Kano, Shinichi Matsuge, Hiromitsu Domen, Hiromi Kanno, Yutaka Hatanaka, Kanako C. Hatanaka, Kichizo Kaga, Yoshiro Matsui, Yoshihiro Matsuno, Marc De Perrot, Kazuhiro Yasufuku
    INTERNATIONAL JOURNAL OF ONCOLOGY, 49, 6, 2411, 2420, Dec. 2016, [Peer-reviewed], [Lead author]
    English, Scientific journal
  • Validating Spectrum Image Analysis of Lymph Nodes During Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Patients With Lung Cancer
    Ujiie, Hideki, Nakajima, Takahiro, Hu, Hsin-pei, Fujino, Kosuke, Kato, Tatsuya, Yasufuku, Kazuhiro
    CHEST, 150, 4, 1045A, 1045A, Oct. 2016
    English
  • An Integrated Nanotechnology-Enabled Transbronchial Image-Guided Intervention Strategy for Peripheral Lung Cancer
    Cheng S. Jin, Hironobu Wada, Takashi Anayama, Patrick Z. McVeigh, Hsin Pei Hu, Kentaro Hirohashi, Takahiro Nakajima, Tatsuya Kato, Shaf Keshavjee, David Hwang, Brian C. Wilson, Gang Zheng, Kazuhiro Yasufuku
    CANCER RESEARCH, 76, 19, 5870, 5880, Oct. 2016, [Peer-reviewed]
    English, Scientific journal
  • Multi-Modal Imaging in a Mouse Model of Orthotopic Lung Cancer
    Priya Patel, Tatsuya Kato, Hideki Ujiie, Hironobu Wada, Daiyoon Lee, Hsin-pei Hu, Kentaro Hirohashi, Jin Young Ahn, Jinzi Zheng, Kazuhiro Yasufuku
    PLOS ONE, 11, 9, e0161991, Sep. 2016, [Peer-reviewed]
    English, Scientific journal
  • Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma
    Tatsuya Kato, Daiyoon Lee, Licun Wu, Priya Patel, Ahn Mn Young, Hironobu Wada, Hsin-Pei Hu, Hideki Ujiie, Mitsuhito Kaji, Satoshi Kano, Shinichi Matsuge, Hiromitsu Domen, Kichizo Kaga, Yoshiro Matsui, Hiromi Kanno, Yutaka Hatanaka, Kanako C. Hatanaka, Yoshihiro Matsun, Marc de Perrot, Kazuhiro Yasufuku
    INTERNATIONAL JOURNAL OF ONCOLOGY, 49, 2, 448, 456, Aug. 2016, [Peer-reviewed], [Lead author], ［Internationally co-authored］
    English, Scientific journal
  • Thoracoscopic ultrasonography for localization of subcentimetre lung nodules(aEuro)
    Hironobu Wada, Takashi Anayama, Kentaro Hirohashi, Takahiro Nakajima, Tatsuya Kato, Thomas K. Waddell, Shaf Keshavjee, Ichiro Yoshino, Kazuhiro Yasufuku
    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 49, 2, 690, 697, Feb. 2016, [Peer-reviewed]
    English, Scientific journal
  • Overexpression of KIF23 predicts clinical outcome in primary lung cancer patients
    Tatsuya Kato, Hironobu Wada, Priya Patel, Hsin-pei Hu, Daiyoon Lee, Hideki Ujiie, Kentaro Hirohashi, Takahiro Nakajima, Masaaki Sato, Mitsuhito Kaji, Kichizo Kaga, Yoshiro Matsui, Ming-Sound Tsao, Kazuhiro Yasufuku
    LUNG CANCER, 92, 53, 61, Feb. 2016, [Peer-reviewed], [Lead author], ［Internationally co-authored］, [International Magazine]
    English, Scientific journal
  • Minimally Invasive Electro-Magnetic Navigational Bronchoscopy-Integrated Near-Infrared-Guided Sentinel Lymph Node Mapping in the Porcine Lung
    Hironobu Wada, Kentaro Hirohashi, Takashi Anayama, Takahiro Nakajima, Tatsuya Kato, Harley H. L. Chan, Jimmy Qiu, Michael Daly, Robert Weersink, David A. Jaffray, Jonathan C. Irish, Thomas K. Waddell, Shaf Keshavjee, Ichiro Yoshino, Kazuhiro Yasufuku
    PLOS ONE, 10, 5, e0126945, May 2015, [Peer-reviewed]
    English, Scientific journal
  • Photothermal ablation of human lung cancer by low-power near-infrared laser and topical injection of indocyanine green
    Kentaro Hirohashi, Takashi Anayama, Hironobu Wada, Takahiro Nakajima, Tatsuya Kato, Shaf Keshavjee, Kazumasa Orihashi, Kazuhiro Yasufuku
    Journal of Bronchology and Interventional Pulmonology, 22, 2, 99, 106, Lippincott Williams and Wilkins, 24 Apr. 2015, [Peer-reviewed]
    English, Scientific journal
  • Thoracoscopic ultrasonography for localization of subcentimetre lung nodules†.
    Wada H, Anayama T, Hirohashi K, Nakajima T, Kato T, Waddell TK, Keshavjee S, Yoshino I, Yasufuku K
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 49, 2, 690, 7, Apr. 2015, [Peer-reviewed]
    Japanese, Owner : NLM

    Status : Publisher

    PubModel : Print-Electronic

    Language : ENG

    Pagination :
  • Assessment of the new thin convex probe endobronchial ultrasound bronchoscope and the dedicated aspiration needle: A preliminary study in the porcine lung
    Hironobu Wada, Kentaro Hirohashi, Takahiro Nakajima, Takashi Anayama, Tatsuya Kato, Alexandria Grindlay, Judy McConnell, Ichiro Yoshino, Kazuhiro Yasufuku
    Journal of Bronchology and Interventional Pulmonology, 22, 1, 20, 27, Lippincott Williams and Wilkins, 16 Mar. 2015, [Peer-reviewed]
    English, Scientific journal
  • A Case of Castleman's Disease with Myasthenia Gravis
    Keidai Ishikawa, Tatsuya Kato, Masato Aragaki, Toshiro Ohbuchi, Sachiko Kimura, Yoshiro Matsui, Mitsuhito Kaji
    ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, 20, 585, 588, 2014, [Peer-reviewed]
    English, Scientific journal
  • Reduced port video-assisted thoracoscopic surgery using a needle scope for lung and mediastinal lesions
    Kichizo Kaga, Yasuhiro Hida, Reiko Nakada-Kubota, Kazuto Ohtaka, Jun Muto, Keidai Ishikawa, Tatsuya Kato, Yoshiro Matsui
    INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 17, 2, 268, 272, Aug. 2013, [Peer-reviewed]
    English, Scientific journal
  • RASEF is a Novel Diagnostic Biomarker and a Therapeutic Target for Lung Cancer
    Hideto Oshita, Ryohei Nishino, Atsushi Takano, Takashi Fujitomo, Masato Aragaki, Tatsuya Kato, Hirohiko Akiyama, Eiju Tsuchiya, Nobuoki Kohno, Yusuke Nakamura, Yataro Daigo
    MOLECULAR CANCER RESEARCH, 11, 8, 937, 951, Aug. 2013, [Peer-reviewed]
    English, Scientific journal
  • Thrombosis in the pulmonary vein stump after left upper lobectomy as a possible cause of cerebral infarction.
    Ohtaka K, Hida Y, Kaga K, Kato T, Muto J, Nakada-Kubota R, Sasaki T, Matsui Y
    The Annals of thoracic surgery, 95, 6, 1924, 1928, Elsevier, Jun. 2013, [Peer-reviewed]
    English, Background. Thrombus in the stump of the pulmonary vein (PV) is not a well-known complication after lung resection, and it has the potential to cause embolism to vital organs. To clarify the frequency, risk factors, and cause of this complication, a retrospective clinical study of patients who underwent lobectomy was performed. Methods. The study evaluated 193 patients with primary lung cancer who underwent lobectomy from 2005 to 2011 and contrast-enhanced chest computed tomography (CT) within 2 years after lobectomy. Contrast-enhanced CT was retrospectively interpreted to check for thrombus in the PV stump. Results. The operative procedures were 65 right upper lobectomies, 14 right middle lobectomies, 40 right lower lobectomies, 52 left upper lobectomies (LUL), and 22 left lower lobectomies. Thrombus developed in the PV stump in 7 of the 193 patients (3.6%) after lobectomy. All patients with thrombus had undergone LUL, and 13.5% of those who had undergone LUL developed thrombus. Univariate analyses revealed that LUL and operation time were significant risk factors and that adjuvant chemotherapy was marginally significant. It appears that thrombus may be attributable to the length of the PV stump. Measurement of the length of the PV stump using 3-dimensional CT images of the PV revealed that the stump of the left superior PV was longer than the others. Conclusions. Thrombus in the PV stump occurred in 13.5% of patients after LUL. These findings suggest that contrast-enhanced CT should be recommended for patients after LUL to help identify those with a high risk for thromboembolism. (C) 2013 by The Society of Thoracic Surgeons
  • Optimal predictive value of preoperative serum carcinoembryonic antigen for surgical outcomes in stage I non-small cell lung cancer: differences according to histology and smoking status.
    Tatsuya Kato, Keidai Ishikawa, Masato Aragaki, Masaaki Sato, Kenzo Okamoto, Tetsuya Ishibashi, Koji Oba, Mitsuhito Kaji
    Journal of surgical oncology, 107, 6, 619, 24, May 2013, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
    English, BACKGROUND: The cutoff value of preoperative serum carcinoembryonic antigen (CEA) levels has not been investigated using appropriate subgroup analyses for non-small cell lung carcinoma (NSCLC). This study was undertaken to determine whether the most predictive preoperative CEA level for risk of recurrence differs according to histological type, and how smoking status influences predictive values in Stage I NSCLC. METHODS: Subjects comprised Stage I NSCLC patients [141 patients with adenocarcinoma (ADC) and 36 with squamous cell carcinoma (SCC)]. RESULTS: In patients with Stage I ADC, recurrence-free survival (RFS) differed most significantly at a preoperative CEA level of 2.5 ng/ml, regardless of smoking status. Cases with preoperative CEA >2.5 ng/ml correlated with male sex, high maximum standard uptake value on (18) F-fluorodeoxyglucose positron emission tomography, poorer histopathological grade, lymphatic invasion, and smoking status. Importantly, preoperative CEA >2.5 ng/ml was identified as an independent risk factor for recurrence (P = 0.0015). Conversely, in patients with SCC, a preoperative CEA level of 3.0 ng/ml was the most predictive threshold. CONCLUSIONS: Thresholds of preoperative CEA should be considered when predicting risk of relapse, even if these levels are within normal limits, as optimal cutoff levels may vary according to histological type.
  • 分葉不全に対する完全胸腔鏡下右上葉切除のコツ　　　　　　　　　　　　　　　
    樋田 泰浩, 加賀 基知三, 加藤 達哉, 石川 慶大, 久保田 玲子[中田], 佐藤 大介, 松居 喜郎
    日本呼吸器外科学会雑誌, 27, 3, V01, 07, (NPO)日本呼吸器外科学会, Apr. 2013
    Japanese
  • Limited resection and two-staged lobectomy for non-small cell lung cancer with ground-glass opacity.
    Ohtaka K, Hida Y, Kaga K, Kato T, Muto J, Nakada-Kubota R, Hirano S, Matsui Y
    Journal of cardiothoracic surgery, 8, 111, BioMed Central, Apr. 2013, [Peer-reviewed]
    English, Background: Lung tumors showing ground-glass opacities on high-resolution computed tomography indicate the presence of inflammation, atypical adenomatous hyperplasia, or localized bronchioloalveolar carcinoma. We adopted a two-staged video-assisted thoracoscopic lobectomy strategy involving completion lobectomy for localized bronchioloalveolar carcinoma with an invasive component according to postoperative pathological examination by permanent section after partial resection. Methods: Forty-one patients with undiagnosed small peripheral ground-glass opacity lesions underwent partial resection from 2001 to 2007 in Hokkaido University Hospital. Localized bronchioloalveolar carcinoma was classified according to the Noguchi classification for adenocarcinoma. Malignant lesions other than Noguchi types A and B were considered for completion lobectomy and systemic mediastinal lymphadenectomy. Perioperative data of completion video-assisted thoracoscopic lobectomies were compared with data of 67 upfront video-assisted thoracoscopic lobectomies for clinical stage IA adenocarcinoma performed during the same period. Results: Postoperative pathological examination revealed 35 malignant and 6 non-malignant diseases. Histologically, all of the malignant diseases were adenocarcinomas of Noguchi type A (n = 7), B (n = 9), C (n = 18), and F (n = 1). Eleven of 19 patients (58%) with Noguchi type C or F underwent two-staged video-assisted thoracoscopic lobectomy. Three patients refused a second surgery. There was no cancer recurrence. The two-staged lobectomy group had a significantly longer operative time and more blood loss than the upfront lobectomy group. There was no surgical mortality or cancer recurrence. Conclusions: Two-staged lobectomy for undiagnosed small peripheral ground-glass opacity lesions showed satisfactory oncological results. However, low compliance for and invasiveness of the second surgery are concerns associated with this strategy.
  • Method for the validation of immunohistochemical staining using SCID mouse xenografts: Expression of CD40 and CD154 in human non-small cell lung cancer
    Keidai Ishikawa, Masaki Miyamoto, Tatsuya Yoshioka, Masatoshi Kadoya, Li Li, Roshan Mishra, Kazuomi Ichinokawa, Yasuhito Shoji, Yoshiyuki Matsumura, Yasuhiro Hida, Kichizo Kaga, Tatsuya Kato, Mitsuhito Kaji, Toshiro Ohbuchi, Tomoo Itoh, Hirotoshi Dosaka-Akita, Yoshiro Matsui, Satoshi Hirano
    ONCOLOGY REPORTS, 29, 4, 1315, 1321, Apr. 2013, [Peer-reviewed]
    English, Scientific journal
  • Endobronchial closure of a bronchopleural fistula using a fibrin glue-coated collagen patch and fibrin glue
    Keidai Ishikawa, Tatsuya Kato, Masato Aragaki, Ryunosuke Hase, Toyohiro Saikai, Yoshiro Matsui, Mitsuhito Kaji
    Annals of Thoracic and Cardiovascular Surgery, 19, 6, 423, 427, 2013, [Peer-reviewed]
    English, Scientific journal
  • 区域切除 Hybrid or Complete VATS 完全胸腔鏡下肺区域切除と縦隔リンパ節郭清　　　　　　　　　　　　　　　
    樋田 泰浩, 加賀 基知三, 加藤 達哉, 石川 慶大, 久保田 玲子[中田], 佐藤 彰記, 高野 博信, 松居 喜郎
    日本内視鏡外科学会雑誌, 17, 7, 268, 268, (一社)日本内視鏡外科学会, Dec. 2012
    Japanese
  • 【胸腔鏡を用いた縦隔疾患の手術適応とその手技】外科的アプローチの選択 縦隔腫瘤性病変に対する胸腔鏡手術の適応
    樋田 泰浩, 武藤 潤, 加賀 基知三, 加藤 達哉, 石川 慶大, 久保田 玲子[中田], 大高 和人, 松居 喜郎
    胸部外科, 65, 11, 934, 938, (株)南江堂, Oct. 2012
    Japanese
  • [Indication of video-assisted thoracic surgery for mediastinal mass lesions].
    Hida Y, Muto J, Kaga K, Kato T, Ishikawa K, Nakada-Kubota R, Ohtaka K, Matsui Y
    Kyobu geka. The Japanese journal of thoracic surgery, 65, 11, 934, 938, Oct. 2012
  • Spontaneous pneumothorax in a patient with dendriform pulmonary ossification: report of a case
    Tatsuya Kato, Keidai Ishikawa, Masatoshi Kadoya, Kenzo Okamoto, Mitsuhito Kaji
    SURGERY TODAY, 42, 9, 903, 908, Sep. 2012, [Peer-reviewed], [Lead author]
    English, Scientific journal
  • Overexpression of CDC20 predicts poor prognosis in primary non-small cell lung cancer patients
    Tatsuya Kato, Yataro Daigo, Masato Aragaki, Keidai Ishikawa, Masaaki Sato, Mitsuhito Kaji
    JOURNAL OF SURGICAL ONCOLOGY, 106, 4, 423, 430, Sep. 2012, [Peer-reviewed], [Lead author]
    English, Scientific journal
  • Angiolymphatic invasion exerts a strong impact on surgical outcomes for stage I lung adenocarcinoma, but not non-adenocarcinoma
    Tatsuya Kato, Keidai Ishikawa, Masato Aragaki, Masaaki Sato, Kenzo Okamoto, Tetsuya Ishibashi, Mitsuhito Kaji
    LUNG CANCER, 77, 2, 394, 400, Aug. 2012, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • 完全胸腔鏡下気管支断端肋間筋弁被覆　　　　　　　　　　　　　　　
    樋田 泰浩, 加賀 基知三, 加藤 達哉, 井上 玲, 大高 和人, 武藤 潤, 武内 慎太郎, 松居 喜郎
    日本呼吸器外科学会雑誌, 26, 3, RS03, 02, (NPO)日本呼吸器外科学会, Apr. 2012
    Japanese
  • 完全胸腔鏡下肺区域切除の適応、手技およびその成績　　　　　　　　　　　　　　　
    加賀 基知三, 樋田 泰浩, 加藤 達哉, 井上 玲, 大高 和人, 武藤 潤, 中田 玲子, 松居 喜郎
    日本呼吸器外科学会雑誌, 26, 3, RV10, 05, (NPO)日本呼吸器外科学会, Apr. 2012
    Japanese
  • 原発性肺腺癌における術前血清CYFRA値と予後との関連に関する検討　　　　　　　　　　　　　　　
    武内 慎太郎, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 中田 玲子, 大高 和人, 武藤 潤, 井上 玲, 平野 聡, 松居 喜郎
    日本呼吸器外科学会雑誌, 26, 3, O02, 02, (NPO)日本呼吸器外科学会, Apr. 2012
    Japanese
  • 肺癌術後脳血管障害の機序と対策 左上葉切除術は肺静脈断端内血栓の危険因子である　　　　　　　　　　　　　　　
    大高 和人, 樋田 泰浩, 加賀 基知三, 加藤 達哉, 井上 玲, 武藤 潤, 中田 玲子, 松居 喜郎
    日本呼吸器外科学会雑誌, 26, 3, O12, 01, (NPO)日本呼吸器外科学会, Apr. 2012
    Japanese
  • 病理病期III悪性胸膜中皮腫切除症例の検討　　　　　　　　　　　　　　　
    中田 玲子, 樋田 泰浩, 加賀 基知三, 加藤 達哉, 井上 玲, 大高 和人, 武藤 潤, 平野 聡, 松井 喜郎
    日本呼吸器外科学会雑誌, 26, 3, O13, 05, (NPO)日本呼吸器外科学会, Apr. 2012
    Japanese
  • 横隔膜交通症手術における交通部同定法としての気腹法の有用性　　　　　　　　　　　　　　　
    井上 玲, 樋田 泰浩, 加賀 基知三, 武藤 潤, 大高 かずと, 加藤 達哉, 加藤 弘明, 成田 吉明, 樫村 暢一, 平野 聡, 松居 喜郎
    日本呼吸器外科学会雑誌, 26, 3, O29, 03, (NPO)日本呼吸器外科学会, Apr. 2012
    Japanese
  • 原発巣へのFDG集積による非浸潤性非小細胞肺癌の判定　　　　　　　　　　　　　　　
    武藤 潤, 樋田 泰浩, 加賀 基知三, 加藤 達哉, 大高 和人, 井上 玲, 中田 玲子, 平野 聡, 松居 喜郎
    日本呼吸器外科学会雑誌, 26, 3, P16, 02, (NPO)日本呼吸器外科学会, Apr. 2012
    Japanese
  • 頸部切開と胸腔鏡操作で摘除し得た縦隔上部胸腺腫の一例　　　　　　　　　　　　　　　
    阿部 早和子, 樋田 泰浩, 加賀 基知三, 加藤 達哉, 大高 和人, 武藤 潤, 井上 玲, 中田 玲子, 松居 喜郎
    日本呼吸器外科学会雑誌, 26, 3, P45, 03, (NPO)日本呼吸器外科学会, Apr. 2012
    Japanese
  • Overexpression of KIAA0101 predicts poor prognosis in primary lung cancer patients
    Tatsuya Kato, Yataro Daigo, Masato Aragaki, Keidai Ishikawa, Masaaki Sato, Mitsuhito Kaji
    LUNG CANCER, 75, 1, 110, 118, Jan. 2012, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • Overexpression of MAD2 predicts clinical outcome in primary lung cancer patients
    Tatsuya Kato, Yataro Daigo, Masato Aragaki, Keidai Ishikawa, Masaaki Sato, Satoshi Kondo, Mitsuhito Kaji
    LUNG CANCER, 74, 1, 124, 131, Oct. 2011, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • 18F-FDG uptake in primary lung cancer as a predictor of intratumoral vessel invasion
    Tetsuya Ishibashi, Mitsuhito Kaji, Tatsuya Kato, Keidai Ishikawa, Masatoshi Kadoya, Nagara Tamaki
    ANNALS OF NUCLEAR MEDICINE, 25, 8, 547, 553, Oct. 2011, [Peer-reviewed]
    English, Scientific journal
  • Pleomorphic carcinoma of the lung arising in a patient with Li-Fraumeni syndrome: Report of a case
    Tatsuya Kato, Keidai Ishikawa, Masaaki Satoh, Satoshi Kondo, Mitsuhito Kaji
    SURGERY TODAY, 41, 6, 841, 845, Jun. 2011, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • 非小細胞肺癌症例においてHLA Class IH鎖分子発現低下は予後不良因子である(Cases of NSCLC that have down-regulated expression of HLA class I heavy chain show poor prognoses)　　　　　　　　　　　　　　　
    市之川 一臣, 宮本 正樹, 石川 慶大, 加藤 達哉, 吉岡 達也, ローシャン・ミシュラ, 東海林 安人, 樋田 泰浩, 加賀 基知三, 平野 聡, 加地 苗人, 近藤 哲
    日本癌学会総会記事, 67回, 217, 217, 日本癌学会, Sep. 2008
    English
  • Up-regulation of CD40 with juxtacrine activity in human nonsmall lung cancer cells correlates with poor prognosis
    Keidai Ishikawa, Masaki Miyamoto, Tatsuya Yoshioka, Tatsuya Kato, Mitsuhito Kaji, Toshiro Ohbuchi, Satoshi Hirano, Tomoo Itoh, Hirotoshi Dosaka-Akita, Satoshi Kondo
    CANCER, 113, 3, 530, 541, Aug. 2008, [Peer-reviewed]
    English, Scientific journal
  • Activation of placenta-specific transcription factor distal-less homeobox 5 predicts clinical outcome in primary lung cancer patients
    Tatsuya Kato, Nagato Sato, Atsushi Takano, Masaki Miyamoto, Hitoshi Nishimura, Eiju Tsuchiya, Satoshi Kondo, Yusuke Nakamura, Yataro Daigo
    CLINICAL CANCER RESEARCH, 14, 8, 2363, 2370, Apr. 2008, [Peer-reviewed], [Lead author]
    English, Scientific journal
  • Two cases of FDG-PET-negative lung cancer
    UEHARA Hirofumi, KAJI Mitsuhito, KATO Tatsuya
    The Journal of the Japanese Association for Chest Surgery, 22, 2, 169, 174, The Japanese Association for Chest Surgery, 07 Mar. 2008
    Japanese, Recently, 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) has come to be considered a useful tool for the diagnosis of lung cancer. Especially, FDG-PET is very sensitive to the detection of lung cancer appearing as solid tumors on chest computed tomography (CT) scanning. However, false negative cases are still sometime reported. We report two cases of mucinous type of bronchioloalveolar carcinoma with negative FDG-PET scanning. Mucin of malignant cells can be a cause of false-negative FDG-PET scanning. Clinicians should note that FDG-PET-negative lung tumors might be a mucinous type of bronchioloalveolar carcinoma.
  • P34-07 当科における肺孤立性病変に対するFDG-PET偽陽性・偽陰性症例の検討(肺癌・PET,第25回日本呼吸器外科学会総会)
    加藤 達哉, 石川 慶大, 加地 苗人
    日本呼吸器外科学会雑誌, 22, 3, 532, 532, 特定非営利活動法人 日本呼吸器外科学会, 2008
    Japanese
  • Activation of holliday junction-recognizing protein involved in the chromosomal stability and immortality of cancer cells
    Tatsuya Kato, Nagato Sato, Satoshi Hayama, Takumi Yamabuki, Tomoo Ito, Masaki Miyamoto, Satoshi Kondo, Yusuke Nakamura, Yataro Daigo
    CANCER RESEARCH, 67, 18, 8544, 8553, Sep. 2007, [Peer-reviewed], [Lead author]
    English, Scientific journal
  • ヒト小細胞肺癌細胞におけるjuxtacrine活性によるCD40の上方制御は予後不良と関連する(Up-regulation of CD40 with juxtacrine activity in human non-small lung cancer cells correlates with poor prognosis)　　　　　　　　　　　　　　　
    石川 慶大, 宮本 正樹, 吉岡 達也, 樋田 泰浩, 加藤 達哉, 加地 苗人, 秋田 弘俊, 近藤 哲
    日本癌学会総会記事, 66回, 375, 375, 日本癌学会, Aug. 2007
    English
  • Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis
    Satoshi Hayama, Yataro Daigo, Takumi Yamabuki, Daizaburo Hirata, Tatsuya Kato, Masaki Miyamoto, Tomoo Ito, Eiju Tsuchiya, Satoshi Kondo, Yusuke Nakamura
    CANCER RESEARCH, 67, 9, 4113, 4122, May 2007, [Peer-reviewed]
    English, Scientific journal
  • Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas
    Takumi Yamabuki, Atsushi Takano, Satoshi Hayama, Nobuhisa Ishikawa, Tatsuya Kato, Masaki Miyamoto, Tomoo Ito, Hiroyuki Ito, Yohei Miyagi, Haruhiko Nakayama, Masahiro Fujita, Masao Hosokawa, Eiju Tsuchiya, Nobuoki Kohno, Satoshi Kondo, Yusuke Nakamura, Yataro Daigo
    CANCER RESEARCH, 67, 6, 2517, 2525, Mar. 2007, [Peer-reviewed]
    English, Scientific journal
  • Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer
    Chie Suzuki, Koji Takahashi, Satoshi Hayama, Nobuhisa Ishikavva, Tatsuya Kato, Tomoo Ito, Eiju Tsuchiya, Yusuke Nakamura, Yataro Daigo
    MOLECULAR CANCER THERAPEUTICS, 6, 2, 542, 551, Feb. 2007, [Peer-reviewed]
    English, Scientific journal
  • PS-070-5 多発癌家系に発症した若年者原発性肺多形癌の一例(肺癌症例8, 第24回日本呼吸器外科学会総会号)
    加藤 達哉, 上原 浩文, 加地 苗人
    日本呼吸器外科学会雑誌, 21, 3, 458, 458, 特定非営利活動法人 日本呼吸器外科学会, 2007
    Japanese
  • PS-001-5 原発巣のCTおよびFDG-PET所見と病理学的リンパ節転移に関する検討(診断と手術適応1, 第24回日本呼吸器外科学会総会号)
    上原 浩文, 加地 苗人, 加藤 達哉
    日本呼吸器外科学会雑誌, 21, 3, 362, 362, 特定非営利活動法人 日本呼吸器外科学会, 2007
    Japanese
  • RV-02-2 当科における完全鏡視下右肺上葉切除術(右上葉切除(2), 第24回日本呼吸器外科学会総会号)
    加地 苗人, 加藤 達哉, 上原 浩文
    日本呼吸器外科学会雑誌, 21, 3, 322, 322, 特定非営利活動法人 日本呼吸器外科学会, 2007
    Japanese
  • Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer
    Tatsuya Kato, Satoshi Hayama, Takumi Yamabuki, Nobuhisa Ishikawa, Masaki Miyamoto, Tomoo Ito, Eiju Tsuchiya, Satoshi Kondo, Yusuke Nakamura, Yataro Daigo
    CLINICAL CANCER RESEARCH, 13, 2, 434, 442, Jan. 2007, [Peer-reviewed], [Lead author]
    English, Scientific journal
  • Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis
    Satoshi Hayama, Yataro Daigo, Tatsuya Kato, Nobuhisa Ishikawa, Takumi Yamabuki, Masaki Miyamoto, Tomoo Ito, Eiju Tsuchiya, Satoshi Kondo, Yusuke Nakamura
    CANCER RESEARCH, 66, 21, 10339, 10348, Nov. 2006, [Peer-reviewed]
    English, Scientific journal
  • The neuromedin U-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer
    Koji Takahashi, Chiyuki Furukawa, Atsushi Takano, Nobuhisa Ishikawa, Tatsuya Kato, Satoshi Hayama, Chie Suzuki, Wataru Yasui, Kouki Inai, Saburo Sone, Tomoo Ito, Fetoshi Nishimura, Eiju Tsuchiya, Yusuke Nakamura, Yataro Daigo
    CANCER RESEARCH, 66, 19, 9408, 9419, Oct. 2006, [Peer-reviewed]
    English, Scientific journal
  • Characterization of SEZ6L2 cell-surface protein as a novel prognostic marker for lung cancer
    N Ishikawa, Y Daigo, A Takano, M Taniwaki, T Kato, S Tanaka, W Yasui, Y Takeshima, K Inai, H Nishimura, E Tsuchiya, N Kohno, Y Nakamura
    CANCER SCIENCE, 97, 8, 737, 745, Aug. 2006, [Peer-reviewed]
    English, Scientific journal
  • Genome-wide gene expression profile analysis of esophageal squamous cell carcinomas
    T Yamabuki, Y Daigo, T Kato, S Hayama, T Tsunoda, M Miyamoto, T Ito, M Fujita, M Hosokawa, S Kondo, Y Nakamura
    INTERNATIONAL JOURNAL OF ONCOLOGY, 28, 6, 1375, 1384, Jun. 2006, [Peer-reviewed]
    English, Scientific journal
  • ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway
    C Suzuki, Y Daigo, N Ishikawa, T Kato, S Hayama, T Ito, E Tsuchiya, Y Nakamura
    CANCER RESEARCH, 65, 24, 11314, 11325, Dec. 2005, [Peer-reviewed]
    English, Scientific journal
  • Increases of amphiregulin and transforming growth factor-alpha in serum as predictors of poor response to gefitinib among patients with advanced non-small cell lung cancers
    N Ishikawa, Y Daigo, A Takano, M Taniwaki, T Kato, S Hayama, H Murakami, Y Takeshima, K Inai, H Nishimura, E Tsuchiya, N Kohno, Y Nakamura
    CANCER RESEARCH, 65, 20, 9176, 9184, Oct. 2005, [Peer-reviewed]
    English, Scientific journal
  • Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer
    C Furukawa, Y Daigo, N Ishikawa, T Kato, T Ito, E Tsuchiya, S Sone, Y Nakamura
    CANCER RESEARCH, 65, 16, 7102, 7110, Aug. 2005, [Peer-reviewed]
    English, Scientific journal
  • A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis
    T Kato, Y Daigo, S Hayama, N Ishikawa, T Yamabuki, T Ito, M Myamoto, S Kondo, Y Nakamura
    CANCER RESEARCH, 65, 13, 5638, 5646, Jul. 2005, [Peer-reviewed], [Lead author]
    English, Scientific journal
  • Difference of caveolin-1 expression pattern in human lung neoplastic tissue. Atypical adenomatous hyperplasia, adenocarcinoma and squamous cell carcinoma
    T Kato, M Miyamoto, K Kato, Y Cho, T Itoh, T Morikawa, S Okushiba, S Kondo, T Ohbuchi, H Katoh
    CANCER LETTERS, 214, 1, 121, 128, Oct. 2004, [Peer-reviewed], [Lead author]
    English, Scientific journal
  • Inflammatory malignant fibrous histiocytoma of the gallbladder: Report of a case
    T Kato, T Kojima, T Shimizu, H Sasaki, M Abe, S Okushiba, S Kondo, H Kato, H Sato
    SURGERY TODAY, 32, 1, 81, 85, 2002, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • Gastrectomy in combination with a distal splenorenal shunt in a patient with gastric cancer and portal hypertension: Report of a case
    T Kato, H Kato, S Kondo, S Okushiba, T Morikawa
    SURGERY TODAY, 32, 8, 727, 730, 2002, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • Two cases of esophageal cancer with portal hypertension: Esophagectomy with venous shunt procedure
    T Kato, T Motohara, Y Kaneko, H Shikishima, S Okushiba, S Kondo, H Kato
    HEPATO-GASTROENTEROLOGY, 48, 42, 1656, 1658, Nov. 2001, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • GASTROINTESTINAL STROMAL TUMOR WITH PERITONEAL DISSEMINATION ; REPORT OF TWO CASES
    HIRAOKA Kei, MORITA Takayuki, KATOH Tatsuya, SENMARU Naoto, MIYASAKA Yuji, FUJITA Miyoshi, KATOH Hiroyuki
    The journal of the Japanese Practical Surgeon Society, 61, 1, 204, 208, Japan Surgical Association, 25 Jan. 2000
    Japanese, (Case 1) A 70-year-old man was admitted to our hospital because of abdominal distension. An abdominal computed tomography scan showed a large cystic mass of the stomach. The patient was diagnosed as having a submucosal tumor of the stomach and was operated on. (Case 2) A 59-year-old man was admitted to our hospital because of melena. An abdominal computed tomography scan and ultrasonography showed a mass of the small bowel. Partial resection of the jejunum was performed with a diagnosis of small-bowel tumor. During laparotomy in both cases, a large number of small nodules of peritoneum were noted. Histologically, and immunohistochemically, both of the tumors were diagnosed as gastrointestinal stromal tumors (GIST), uncommitted type, with peritoneal dissemination. The prognosis of GIST with unresectable peritoneal dissemination is poor, therefore, surgical resection should be done as soon as possible.
  • A CASE OF LEIOMYOBLASTOMA OF THE ILEUM WITH LIVER METASTASES AND PERITONEAL DISSEMINATION
    HIRAOKA Kei, MORITA Takayuki, FUJITA Miyoshi, MIYASAKA Yuji, SENMARU Naoto, KATOH Tatsuya, KATOH Hiroyuki
    The journal of the Japanese Practical Surgeon Society, 61, 3, 689, 692, Japan Surgical Association, 2000
    A 59-year-old man was admitted to the hospital because of melena and dizziness. Barium X-ray study of the small intestine revealed a filling defect in the ileum. Partial resection of the ileum was performed with a diagnosis of ileal tumor. The tumor was 1.8×1.5×1.8cm in size, and located on a site, 60cm oral to the Bauhin's valve.
    Histopathological diagnosis was leiomyoblastoma. Thereafter the patient had liver metastasis and peritoneal dissemination which were resected respectively, however, he died of metastases to the whole body 4 years and 2 months after the initial operation. Leiomyoblastoma of the small intestine is relatively rare and presents difficulty in diagnosis of the degree of malignancy of the tumor. Surgical resection of the tumor is said to carry a good prognosis. Nevertheless, some patients have a poor prognosis like this case and careful observation of clinical course would be mandatary.
  • Report of a case with crohn's disease presenting as acute appendicitis
    Tatsuya Kato, Tetsufumi Kojima, Tetsuya Shimizu, Syuji Kitashiro, Kazuya Konishi, Takumi Yamabuki, Shunichi Okushiba, Hiroyuki Kato, Hidetoshi Sato
    Japanese Journal of Gastroenterological Surgery, 33, 8, 1529, 1533, Japanese Society of Gastroenterological Surgery, 2000, [Peer-reviewed], [Lead author]
    Japanese, Scientific journal
  • Basaloid-squamous carcinoma of the esophagus: Report of a case
    T Kato, T Morita, M Fujita, Y Miyasaka, S Horita, Y Watanabe, H Kato
    SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 30, 2, 163, 167, 2000, [Peer-reviewed], [Lead author]
    English, Scientific journal
  • Case of retroperitoneal dedifferentiated mixed-type liposarcoma: Comparison of proliferative activity in specimens from four operations
    T Kato, T Motohara, Y Kaneko, H Shikishima, T Takahashi, S Okushiba, S Kondo, H Kato
    JOURNAL OF SURGICAL ONCOLOGY, 72, 1, 32, 36, Sep. 1999, [Peer-reviewed], [Lead author]
    English, Scientific journal
  • Ischemic stricture of the small intestine associated with acute pancreatitis
    T Kato, T Morita, M Fujita, Y Miyasaka, N Senmaru, K Hiraoka, S Horita, S Kondo, H Kato
    INTERNATIONAL JOURNAL OF PANCREATOLOGY, 24, 3, 237, 242, Dec. 1998, [Peer-reviewed], [Lead author]
    English, Scientific journal
  • 胃上部早期胃癌に対する臨床病理学的検討
    平岡 圭, 加藤 達哉, 樋田 泰浩, 宮坂 祐司, 藤田 美芳, 森田 高行, 加藤 紘之
    北海道外科雑誌, 42, 2, 281, 281, 北海道外科学会, Dec. 1997, [Peer-reviewed]
    Japanese

Other Activities and Achievements

Affiliated academic society

  • THE JAPAN LUNG CANCER SOCIETY　　　　　　　　　　　　　　　
  • JAPAN SURGICAL ASSOCIATION　　　　　　　　　　　　　　　
  • THE JAPAN SOCIETY FOR TRANSPLANTATION　　　　　　　　　　　　　　　
  • The Japanese Association for Chest Surgery　　　　　　　　　　　　　　　
  • JAPAN SURGICAL SOCIETY　　　　　　　　　　　　　　　

Research Themes

  • Regulation of genome by hydrogel: Spatial analysis of reprogramming of cancer stem cells towards development of therapeutic drugs
    Grants-in-Aid for Scientific Research
    01 Apr. 2024 - 31 Mar. 2029
    田中 伸哉, 津田 真寿美, 黒川 孝幸, 丸山 玲緒, 加藤 達哉
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (S), Hokkaido University, 24H00037
  • 蛍光スペクトル解析胸腔鏡と5-ALAを応用した新規肺腫瘍マーキング法の開発
    科学研究費助成事業
    04 Jan. 2022 - 31 Mar. 2024
    新垣 雅人, 加藤 達哉, 海老原 裕磨, 櫻井 遊, 樋田 泰浩, 加賀 基知三
    5-ALAの含め複数のポルフィリンを主体としたphotosensityzerを使用し、マウスxenograftモデルでの腫瘍集積性を検討した。使用細胞株はヒト肺腺癌細胞株であるA549と扁平上皮癌細胞株であるH2170、またマウス悪性胸膜中脾腫細胞株であるAE17OVAを使用した。投与濃度と投与から解析までの時間を比較検討し、蛍光強度を解析し、至適投与濃度、至適観察時間を確認した。5ALAも含め複数photosensityzerを投与後にマウスxenograftモデルに投与し、生体内のphotosensityzerの他臓器への集積を蛍光強度にて解析した。photosensityzer投与後のマウスxenograftを使用し、腫瘍摘出後に正常ブタ肺の胸膜直下に留置し、正常肺越しに蛍光を確認できるか確認したところ、maestroを使用し確認したところ,5ALAにおいてはblue light excitationによって励起される蛍光は非常に浅い位置に腫瘍を留置した場合でも観察されなかった。現在red light excitationを使用し、蛍光が観察される条件を検討している。比較対象として使用している他のphotosensityzerは671nmのexcitaion lightにて励起されるため、胸膜下の腫瘍からの蛍光が確認できた。
    並行してrabbit悪性腫瘍株であるVX2を使用し、rabbit orthotopic modelを作成中である同モデルを使用し、5ALAと他のphotosensityzerの集積性、径胸膜的な蛍光の観察が可能かどうか検討予定である。
    日本学術振興会, 基盤研究(C), 北海道大学, 18K08774
  • Development of photoimmunotherapy via O-glycans and siRNA delivery system using iRGD nanoparticles in lung cancer
    Grants-in-Aid for Scientific Research
    01 Apr. 2021 - 31 Mar. 2024
    加藤 達哉, 櫻井 遊, 畑中 佳奈子, 小川 美香子, 樋田 泰浩, 畑中 豊
    本研究はMUC1がん特異的糖鎖抗原のみを選択的に認識する新規モノクローナル抗体（MUC1-Tn抗体）と光感受性物質であるIR700との結合体を用いて、がん細胞のみを特異的に攻撃する新たな治療法を確立し、新規の肺がん治療法の開発を目指すものである。
    今年度は、まず本研究の肝となるMUC1-Tn抗体の供給源である㈱医化学創薬と共同で研究をすすめ、MTAを締結し、本実験で想定される抗体量の確保に努め、動物実験まで含めた十分量の抗体を得ることに成功した。
    さらに今年度は、研究実施計画に則り、まず今後in vitro実験およびin vivo実験に用いる予定のMUC1-Tn高発現の細胞株の選定を行った。乳癌細胞株であるT47DがMUC1-Tnが高発現していることが判明したが、その後21個の肺癌細胞株のセルブロックを作成し、抗MUC1-Tn抗体を用いて免疫染色を行った。うち2株（RERF-LC-KJ, H2228）に高発現が認められ、今後、in vitroおよびin vivo実験に使用可能と判断した。その他、陰性コントロールとしての細胞株も複数選定した。
    また、実験遂行者はすでにIR700と抗MUC1-Tn抗体を合成する技術を習得しており、予備実験として、MUC1-Tn抗体とIR700の結合体を作成し、T47Dに導入後、FACSにて細胞膜表面に抗体が結合していることを確認した。また、タイムラプス顕微鏡でレーザー照射により導入細胞で細胞膜よりブレブが隆起し、細胞死に至ることを確認することができた。したがって今後肺癌細胞株を用いた本実験を開始できる状況にある。
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 21K08876
  • Establishment of near-infrared photoimmunotherapy targeting CD73 using mouse lung cancer model
    Grants-in-Aid for Scientific Research
    01 Apr. 2021 - 31 Mar. 2024
    畑中 豊, 加藤 達哉, 小川 美香子, 畑中 佳奈子
    がん微小環境において，低酸素状態下ではATPからAMPを介しアデノシンを生成する
    CD39/CD73カスケード分子の発現が誘導され，さらにアデノシンはリンパ球上のA2受容体を介して免疫抑制状態を誘導することから，免疫チェックポイント阻害（ICI）療法に対し抵抗性を示す．
    本研究は，先行研究として実施した非小細胞肺癌（NSCLC）の一部でCD73発現が亢進し，またPD-L1発現と相関する点に着目し，(a) NSCLC組織検体を用いたCD73およびPD-L1発現と腫瘍微小環境との関連性について検討し，次いで(b) ヒトおよびマウス肺癌細胞株を用いたCD73-IR700-Cのがん細胞への集積確認と治療効果のin vitro評価，および(c) ヒトおよびマウス肺癌細胞株の移植腫瘍モデルを用いたCD73抗体-IR700結合体（CD73-IR700-C）の腫瘍集積性の確認および近赤外線免疫療法（NIR-PIT）の抗腫瘍効果のin vivo評価を行う．
    本年度は以下の課題に取り組んだ．肺扁平上皮癌症例を用いた組織マイクロアレイ（TMA）標本123例を用いた低酸素関連タンパクの臨床病理学的検討：CD73，PD-L1およびHIF-1a発現について検討したところ，先行研究同様，CD73とPD-L1発現間に有意な関連性（p=0.019）が認められ，またCD73とHIF-1a発現間にも関連傾向（p=0.0548）が観察された．これら３分子の生存解析においては，低発現群に比べ高発現群で，それぞれ有意な無再発生存期間（RFS）の短縮が認められ，さらにCD73高発現/HIF-1a高発現群ではさらに短縮した（p=0.0187）．
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 21K07189
  • Development of photodynamic therapy using tumor-specific small-sized nanoparticle for thoracic malignancy
    Grants-in-Aid for Scientific Research
    25 Aug. 2017 - 31 Mar. 2019
    Kato Tatsuya
    Photodynamic therapy (PDT) irradiates a photosensitizer that accumulates in cancer cells with laser light and causes degenerative necrosis of the tumor by the oxidative action of reactive oxygen species. The purpose of this study was to encapsulate the photosensitizer talaporfin (NPe6) in nanoparticles and to reach the deep part of the tumor with high concentration of NPe6. This novel nanoparticle was observed with an electron microscope to observe the structure of the nanoparticle and to confirm the particle size. Flow cytometry and fluorescence microscopic analyses using lung cancer and mesothelioma cell lines showed that nanoparticle with encapsulated NPe6 enhanced the uptake into cancer cells significantly. It was also confirmed that the uptake was enhanced by adding folic acid as a ligand.
    Japan Society for the Promotion of Science, Grant-in-Aid for Research Activity Start-up, Hokkaido University, 17H06489
  • Development of the drugs targeting lung tumor endothelial cells and the companion diagnosis
    Grants-in-Aid for Scientific Research
    01 Apr. 2012 - 31 Mar. 2016
    Hida Yasuhiro, KAGA KICHIZO, MATSUI YOSHIRO
    Tumor endothelial cells (TEC) from mouse xenografted tumor, especially that from highly metastatic tumor expresses high level of biglycan. Knock down of biglycan by siRNA suppressed tumor cell invasion thorough endothelial cell sheet. Co-implantation of low metastatic tumor cells with TEC developed lung metastases. This metastatic ability was abandoned by suppression of biglycan expression in TEC. Immunohistochemistry of human clinical tumors revealed specific expression of biglycan in TEC. ELISA of serum showed high biglycan level in cancer patients, especially those with metastasis.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 24390324
  • Investigation of the mechanism of enhanced lung metastasis due to exosome from tumor endothelial cells
    Grants-in-Aid for Scientific Research
    01 Apr. 2012 - 31 Mar. 2014
    HIDA Yasuhiro, KAGA Kichizou, MATSUI Yoshirou, KATOH Tatsuya, HIDA Kyoko
    We hypothesized that tumor-associated endothelial cells (TEC) facilitate tumor metastasis. We established TEC from xenograft tumor of the low metastatic malignant melanoma cell , A375 and from that of high metastatic counter part, A375SM("super metasitatic"). Comparison of those 2 TEC revealed specific up regulation of some microRNA in A375SM TEC. Transfection of the microRNA change the phenotype of normal endothelial cells from normal skin to that of A375SM TEC.
    Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 24659623
  • 非小細胞肺癌幹細胞における分泌型miRNAの同定とその治療応用へ向けての解析
    科学研究費助成事業
    2012 - 2012
    加藤 達哉, 樋田 泰浩, 樋田 京子, 加賀 基知三, 松居 喜郎
    我々は、癌幹細胞に特化した「分泌型miRNA」に着目し、「非小細胞肺癌幹細胞における分泌型miRNAの同定とその治療応用へ向けての解析」というテーマで平成24年4月より研究を開始した。まず非小細胞肺癌における癌幹細胞の最も良いsorting方法を検討するため種々の方法を試みたが、中でも我々はsphere形成能を持つ癌細胞がマウス皮下腫瘍形成能を高率に有することに着目した。まず肺癌細胞株を用いてsphere形成能を持つ肺癌幹細胞の培養条件検討を行い、足場非依存性のためにpolyHEMA coatedを使用し、またserum-free、EGF+bFGF+ITS premixの培養液を用いて限界希釈を行ったのち培養を継続することで、同細胞群は約1ヶ月に渡りsphere形成能を維持したまま生育することを見出した。次に培養上清中の癌幹細胞における特異的な分泌型miRNAの検索として、マイクロアレイによる解析を行う方針とした。先に述べたsphere形成能を有する細胞群の培養上清と通常の肺癌細胞培養上清におけるmiRNA発現プロファイルを比較検討するため、両群の培養上清よりキットを用いてmiRNAの抽出を行った。細胞株レベルで条件検討が終了し、実際の臨床検体において同様の研究を開始する予定で倫理申請まで行っていたが、筆頭研究者である加藤達哉が海外へ留学することとなり、今回やむなく研究中止の申請をするに至った。
    日本学術振興会, 基盤研究(C), 北海道大学, 24592078