Nov. 2022, 公益社団法人日本放射線腫瘍学会, 2022年 Gold Medal　　　　　　　　　　　　　　　

Sep. 2022, 公益財団法人伊藤医薬学術交流財団, 第５回伊藤太郎学術賞　　　　　　　　　　　　　　　

Jun. 2022, 日本学士院, 日本学士院賞　　　　　　　　　　　　　　　

Dec. 2020, 第4回日本医療研究開発大賞 経済産業大臣賞　　　　　　　　　　　　　　　

Sep. 2020, 公益社団法人秋山記念生命科学振興財団, 秋山財団賞　　　　　　　　　　　　　　　

Sep. 2018, 一般社団法人日本癌学会, 日本癌学会学術賞 第9回JCA-CHAAO賞　　　　　　　　　　　　　　　

Feb. 2018, 一般社団法人科学技術と経済の会（JATES）, 技術経営・イノベーション賞 科学技術と経済の会会長賞　　　　　　　　　　　　　　　

Dec. 2017, SGL, SGH特別賞　　　　　　　　　　　　　　　
Japan

Jun. 2017, Japan Institute of Invention and Innovation, 恩賜発明賞　　　　　　　　　　　　　　　
Japan

Aug. 2015, MEXT, 産学官連携功労者文部科学大臣賞　　　　　　　　　　　　　　　
Japan

Feb. 2015, Hokkaido, 北海道科学技術賞　　　　　　　　　　　　　　　
Japan

Feb. 2012, Hokkaido Univ,, 北海道大学研究総長賞　　　　　　　　　　　　　　　
Japan

2007, Research Front Award 2007　　　　　　　　　　　　　　　
Japan

Mathematical mechanistic model representing the cancer immunity cycle under radiation effects
Taisuke Takayanagi, Koichi Miyazaki, Kana Yamasaki, Takahiro Yamada, Futaro Ebina, Takahiro Kanehira, Yasuhito Onodera, Keiji Kobashi, Hiroshi Taguchi, Koichi Yasuda, Norio Katoh, Takayuki Hashimoto, Hidefumi Aoyama, Hiroki Shirato, Kenji Chamoto
Scientific Reports, 15, 1, Springer Science and Business Media LLC, 06 Jun. 2025, [Peer-reviewed]
Scientific journal

Health Utility of Pain Response Versus Nonresponse to Palliative Radiation Therapy for Symptomatic Bone Metastases: Analyses Based on Real-World Data from 26 Centers.
Tetsuo Saito, Naoto Shikama, Takeo Takahashi, Hideyuki Harada, Naoki Nakamura, Akifumi Notsu, Hiroki Shirato, Kazunari Yamada, Haruka Uezono, Yutaro Koide, Hikaru Kubota, Takuya Yamazaki, Kei Ito, Joichi Heianna, Yukinori Okada, Ayako Tonari, Norio Katoh, Hitoshi Wada, Yasuo Ejima, Kayo Yoshida, Takashi Kosugi, Shigeo Takahashi, Takafumi Komiyama, Nobue Uchida, Misako Miwa, Miho Watanabe, Hisayasu Nagakura, Hiroko Ikeda, Isao Asakawa, Naoyuki Shigematsu
Journal of palliative medicine, 27 Dec. 2024, [International Magazine]
English, Scientific journal, Background: Utility values of responders and nonresponders are essential inputs in cost-effectiveness studies of radiation therapy for painful bone metastases but, to our knowledge, they have not been reported separately. Objective: We sought to determine the utility values of responders and nonresponders using data from a prospective observational study on bone metastases. Methods: The original prospective observational study was conducted at 26 centers in Japan. Of 232 enrolled patients, 181 whose pain scores at baseline were ≥2 were analyzed. Health-related quality of life (QOL) was measured using the EuroQol 5-dimensions 5-levels (EQ-5D-5L) instrument at baseline and 2- and 6-month follow-up assessments. At follow-up assessments, patients were categorized as responders or nonresponders. Pain response was assessed using the International Consensus Pain Response Endpoints. Results: Of the 181 patients analyzed, 133 (73%) and 84 (46%) were evaluable at the 2- and 6-month follow-up assessment, respectively. The EQ-5D-5L index score (utility) increased from baseline to the 2- and 6-month follow-up assessments; regarding opioid analgesic use, no clear trend was observed during the same period. The mean utility was significantly higher in responders than in nonresponders at both follow-up times. The mean daily oral morphine equivalent dose was significantly lower in responders than in nonresponders at both follow-up times. Conclusion: We determined utility values for responders and nonresponders. Pain response was associated with better QOL and less opioid use. Our utility values according to response status can be used for model input in future cost-effectiveness studies on radiation therapy for bone metastases.

ICRU Report 99, Glossary of Contemporary Terms and Definitions in Radiation Science and Medicine
Shao Hui Huang, Magdalena Bazalova-Carter, Soren M. Bentzen, François Bochud, María-Ester Brandan, David T. Burns, Vincent Grégoire, Roger W. Howell, David A. Jaffray, Thomas R. Mackie, Pawel Olko, Thomas Otto, David W. O. Rogers, Hiroki Shirato, Tzu-Chen Yen, Brian O’Sullivan
Journal of the ICRU, 24, 1, 1, 92, SAGE Publications, 24 Dec. 2024
Scientific journal

Quality of life improvement after radiotherapy for bone metastases assessed using real-world data: a secondary analysis of a Nationwide Multicenter Cohort Study
Nobuko Utsumi, Tetsuo Saito, Naoto Shikama, Takeo Takahashi, Hideyuki Harada, Naoki Nakamura, Shuichi Ueno, Akifumi Notsu, Hiroki Shirato, Kazunari Yamada, Haruka Uezono, Yutaro Koide, Hikaru Kubota, Takuya Yamazaki, Kei Ito, Joichi Heianna, Yukinori Okada, Ayako Tonari, Norio Katoh, Hitoshi Wada, Yasuo Ejima, Kayo Yoshida, Takashi Kosugi, Shigeo Takahashi, Takafumi Komiyama, Nobue Uchida, Misako Miwa, Miho Watanabe, Hisayasu Nagakura, Hiroko Ikeda, Isao Asakawa, Naoyuki Shigematsu
Japanese Journal of Clinical Oncology, Oxford University Press (OUP), 30 Oct. 2024
Scientific journal, Abstract

Objective

Single-center studies or randomized controlled trials have evaluated the impact of radiotherapy for bone metastases on quality of life (QOL). We investigated the real-world impact of radiotherapy for bone metastases on QOL using nationwide multicenter cohort data.

Methods

We conducted a prospective observational study at 26 centers in Japan. Of 333 patients who received radiotherapy for bone metastases between December 2020 and March 2021, 232 (70%) were enrolled in the study. Patient-reported QOL was evaluated at enrollment and at two- and six-month follow-up using the European Organization for Research and Treatment of Cancer (EORTC) QOL Questionnaire Core 15-Palliative and the EORTC QOL Questionnaire Bone Metastases module (QLQ-BM22). Possible predictors (patient-, tumor -, and treatment-related factors) of QOL improvement were screened using logistic regression models.

Results

QOL scores showed significant improvement at two-month follow-up in seven (global health status/QOL, emotional functioning, pain, insomnia, painful sites, pain characteristics and functional interference) of the 14 scales. Of these seven scales, mean improvement ≥ the minimal clinically important difference (defined by a change of 10 or more on the 0 to 100 scale) was seen in four scales (pain, insomnia, pain characteristics and functional interference). We did not find any predictors of QOL improvement in the functional interference scale of QLQ-BM22.

Conclusion

Radiotherapy for bone metastases performed in daily practice is effective in improving some scales of QOL.

Multi-institutional prospective observational study of radiotherapy for metastatic bone tumor.
Hideyuki Harada, Naoto Shikama, Akifumi Notsu, Hiroki Shirato, Kazunari Yamada, Haruka Uezono, Yutaro Koide, Hikaru Kubota, Takuya Yamazaki, Kei Ito, Joichi Heianna, Yukinori Okada, Ayako Tonari, Norio Katoh, Hitoshi Wada, Yasuo Ejima, Kayo Yoshida, Takashi Kosugi, Shigeo Takahashi, Takafumi Komiyama, Nobue Uchida, Misako Miwa, Miho Watanabe, Hisayasu Nagakura, Hiroko Ikeda, Tetsuo Saito, Isao Asakawa, Takeo Takahashi, Naoyuki Shigematsu
Journal of radiation research, 20 Aug. 2024, [International Magazine]
English, Scientific journal, Purpose of this study is to evaluate patient characteristics, treatments and outcomes in bone metastasis radiotherapy practice. Patients for whom radiotherapy for bone metastasis was planned at 26 institutions in Japan between December 2020 and March 2021 were consecutively registered in this prospective, observational study. Study measures included patient characteristics, pain relief, skeletal-related events (SREs), overall survival and incidence of radiation-related adverse events. Pain was evaluated using a numerical rating scale (NRS) from 0 to 10. Irradiated dose was analyzed by the biologically effective dose (BED) assuming α/β = 10. Overall, 232 patients were registered; 224 patients and 302 lesions were fully analyzed. Eastern Cooperative Oncology Group Performance Status was 0/1/2/3/4 in 23%/38%/22%/13%/4%; 59% of patients had spinal metastases and 84% had painful lesions (NRS ≥ 2). BED was <20 Gy (in 27%), 20-30 Gy (24%), 30-40 Gy (36%) and ≥ 40 Gy (13%); 9% of patients were treated by stereotactic body radiotherapy. Grade 3 adverse events occurred in 4% and no grade 4-5 toxicity was reported. Pain relief was achieved in 52% at 2 months. BED is not related to pain relief. The cumulative incidence of SREs was 6.5% (95% confidence interval (CI) 3.1-9.9) at 6 months; no factors were significantly associated with SREs. With spinal lesions, 18% of patients were not ambulatory at baseline and 50% of evaluable patients in this group could walk at 2 months. The 6-month overall survival rate was 70.2% (95% CI 64.2-76.9%). In conclusion, we report real-world details of radiotherapy in bone metastasis.

Chest wall pain after single-fraction thoracic stereotactic ablative Radiotherapy: Dosimetric analysis from the iSABR trial
Brianna Lau, Yufan F. Wu, Sunan Cui, Jie Fu, Scott Jackson, Daniel Pham, Piotr Dubrowski, Shaila Eswarappa, Lawrie Skinner, Hiroki Shirato, Hiroshi Taguchi, Michael F. Gensheimer, Harriet Gee, Alexander L. Chin, Maximilian Diehn, Billy W. Loo, Vitali Moiseenko, Lucas K. Vitzthum
Radiotherapy and Oncology, 196, 110317, 110317, Elsevier BV, Jul. 2024, [Peer-reviewed]
Scientific journal

A novel method for measurements of sleep/wake states, feeding and drinking behaviors using the tracking technique of 3D positions in freely moving mice
Hamada T, Sutherland K, Ishikawa M, Saito J, Miyamoto N, Honma S, Shirato H, Honma K-I ( * Correspondence)
Biochemical and Biophysical Research Communications, Jul. 2024, [Peer-reviewed]
English, Scientific journal

A Single-Institution Prospective Study To Evaluate the Safety and Efficacy of Real- Time Image-Gated Spot-Scanning Proton Therapy (RGPT) for Prostate Cancer.
Kentaro Nishioka, Takayuki Hashimoto, Takashi Mori, Yusuke Uchinami, Rumiko Kinoshita, Norio Katoh, Hiroshi Taguchi, Koichi Yasuda, Yoichi M Ito, Seishin Takao, Masaya Tamura, Taeko Matsuura, Shinichi Shimizu, Hiroki Shirato, Hidefumi Aoyama
Advances in radiation oncology, 9, 5, 101464, 101464, May 2024, [International Magazine]
English, Scientific journal, PURPOSE: In real-time image-gated spot-scanning proton therapy (RGPT), the dose distribution is distorted by gold fiducial markers placed in the prostate. Distortion can be suppressed by using small markers and more than 2 fields, but additional fields may increase the dose to organs at risk. Therefore, we conducted a prospective study to evaluate the safety and short-term clinical outcome of RGPT for prostate cancer. METHODS AND MATERIALS: Based on the previously reported frequency of early adverse events (AE) and the noninferiority margin of 10%, the required number of cases was calculated to be 43 using the one-sample binomial test by the Southwest Oncology Group statistical tools with the one-sided significance level of 2.5% and the power 80%. Patients with localized prostate cancer were enrolled and 3 to 4 pure gold fiducial markers of 1.5-mm diameter were inserted in the prostate. The prescribed dose was 70 Gy(relative biologic effectiveness) in 30 fractions, and treatment was performed with 3 fields from the left, right, and the back, or 4 fields from either side of slightly anterior and posterior oblique fields. The primary endpoint was the frequency of early AE (≥grade 2) and the secondary endpoint was the biochemical relapse-free survival rate and the frequency of late AE. RESULTS: Forty-five cases were enrolled between 2015 and 2017, and all patients completed the treatment protocol. The median follow-up period was 63.0 months. The frequency of early AE (≥grade 2) was observed in 4 cases (8.9%), therefore the noninferiority was verified. The overall 5-year biochemical relapse-free survival rate was 88.9%. As late AE, grade 2 rectal bleeding was observed in 8 cases (17.8%). CONCLUSIONS: The RGPT for prostate cancer with 1.5-mm markers and 3- or 4- fields was as safe as conventional proton therapy in early AE, and its efficacy was comparable with previous studies.

The lipid-binding D4 domain of perfringolysin O facilitates the active loading of exogenous cargo into extracellular vesicles.
Abayomi Emmanuel Opadele, Soichiro Nishioka, Ping-Hsiu Wu, Quynh-Thu Le, Hiroki Shirato, Jin-Min Nam, Yasuhito Onodera
FEBS letters, 598, 4, 446, 456, Feb. 2024, [International Magazine]
English, Scientific journal, Whereas extracellular vesicles (EVs) have been engineered for cargo loading, innovative strategies for it can still be developed. Here, we describe domain 4 (D4), a cholesterol-binding domain derived from perfringolysin O, as a viable candidate for EV cargo loading. D4 and its mutants localized to the plasma membrane and the membranes of different vesicular structures in the cytoplasm, and facilitate the transport of proteins of interest (POIs) into EVs. D4-EVs were internalized by recipient cells analogous to EVs engineered with CD9. Intracellular cargo discharge from D4-EVs was successfully detected with the assistance of vesicular stomatitis virus glycoprotein. This study presents a novel strategy for recruiting POIs into EVs via a lipid-binding domain that ensures content release in recipient cells.

Biomedical advances and future prospects of high-precision three-dimensional radiotherapy and four-dimensional radiotherapy
Hiroki SHIRATO
Proceedings of the Japan Academy, Series B, 99, 9, 389, 426, Japan Academy, 10 Nov. 2023, [Peer-reviewed], [Lead author]
Scientific journal

Individualized Stereotactic Ablative Radiotherapy for Lung Tumors: The iSABR Phase 2 Nonrandomized Controlled Trial.
Michael F Gensheimer, Harriet Gee, Hiroki Shirato, Hiroshi Taguchi, John M Snyder, Alexander L Chin, Lucas K Vitzthum, Peter G Maxim, Heather A Wakelee, Joel Neal, Millie Das, Daniel T Chang, Elizabeth Kidd, Steven L Hancock, David B Shultz, Kathleen C Horst, Quynh-Thu Le, Samantha Wong, Eleanor Brown, Ngan Nguyen, Rachel Liang, Billy W Loo Jr, Maximilian Diehn
JAMA oncology, 9, 11, 1525, 1534, 01 Nov. 2023, [International Magazine]
English, Scientific journal, IMPORTANCE: Stereotactic ablative radiotherapy (SABR) is used for treating lung tumors but can cause toxic effects, including life-threatening damage to central structures. Retrospective data suggested that small tumors up to 10 cm3 in volume can be well controlled with a biologically effective dose less than 100 Gy. OBJECTIVE: To assess whether individualizing lung SABR dose and fractionation by tumor size, location, and histological characteristics may be associated with local tumor control. DESIGN, SETTING, AND PARTICIPANTS: This nonrandomized controlled trial (the iSABR trial, so named for individualized SABR) was a phase 2 multicenter trial enrolling participants from November 15, 2011, to December 5, 2018, at academic medical centers in the US and Japan. Data were analyzed from December 9, 2020, to May 10, 2023. Patients were enrolled in 3 groups according to cancer type: initial diagnosis of non-small cell lung cancer (NSCLC) with an American Joint Committee on Cancer 7th edition T1-3N0M0 tumor (group 1), a T1-3N0M0 new primary NSCLC with a history of prior NSCLC or multiple NSCLCs (group 2), or lung metastases from NSCLC or another solid tumor (group 3). INTERVENTION: Up to 4 tumors were treated with once-daily SABR. The dose ranged from 25 Gy in 1 fraction for peripheral tumors with a volume of 0 to 10 cm3 to 60 Gy in 8 fractions for central tumors with a volume greater than 30 cm3. MAIN OUTCOME: Per-group freedom from local recurrence (same-lobe recurrence) at 1 year, with censoring at time of distant recurrence, death, or loss to follow-up. RESULTS: In total, 217 unique patients (median [IQR] age, 72 [64-80] years; 129 [59%] male; 150 [69%] current or former smokers) were enrolled (some multiple times). There were 240 treatment courses: 79 in group 1, 82 in group 2, and 79 in group 3. A total of 285 tumors (211 [74%] peripheral and 74 [26%] central) were treated. The most common dose was 25 Gy in 1 fraction (158 tumors). The median (range) follow-up period was 33 (2-109) months, and the median overall survival was 59 (95% CI, 49-82) months. Freedom from local recurrence at 1 year was 97% (90% CI, 91%-99%) for group 1, 94% (90% CI, 87%-97%) for group 2, and 96% (90% CI, 89%-98%) for group 3. Freedom from local recurrence at 5 years ranged from 83% to 93% in the 3 groups. The proportion of patients with grade 3 to 5 toxic effects was low, at 5% (including a single patient [1%] with grade 5 toxic effects). CONCLUSIONS AND RELEVANCE: The results of this nonrandomized controlled trial suggest that individualized SABR (iSABR) used to treat lung tumors may allow minimization of treatment dose and is associated with excellent local control. Individualized dosing should be considered for use in future trials. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01463423.

Factors associated with quality of life in patients receiving palliative radiotherapy for bone metastases: a secondary cross-sectional analysis of data from a prospective multicenter observational study.
Tetsuo Saito, Naoto Shikama, Takeo Takahashi, Hideyuki Harada, Shuichi Ueno, Akifumi Notsu, Hiroki Shirato, Kazunari Yamada, Haruka Uezono, Yutaro Koide, Hikaru Kubota, Takuya Yamasaki, Kei Ito, Joichi Heianna, Yukinori Okada, Ayako Tonari, Norio Katoh, Hitoshi Wada, Yasuo Ejima, Kayo Yoshida, Takashi Kosugi, Shigeo Takahashi, Takafumi Komiyama, Nobue Uchida, Misako Miwa, Miho Watanabe, Hisayasu Nagakura, Hiroko Ikeda, Isao Asakawa, Naoyuki Shigematsu
The British journal of radiology, 20230351, 20230351, 03 Oct. 2023, [International Magazine]
English, Scientific journal, OBJECTIVE: To identify factors significantly associated with quality of life (QOL) and determine if these associations are strong enough to predict certain aspects of QOL without measuring them. METHODS: We conducted an exploratory secondary analysis of baseline data of 224 patients (enrolled between December 2020 and March 2021) from a previously published prospective observational study on radiotherapy for bone metastases at 26 centres. Using univariable linear regression, we assessed the association between patient/treatment factors and QOL scale scores as measured by the European Organization for Research and Treatment of Cancer (EORTC) QOL Questionnaire Core 15-Palliative (QLQ-C15-PAL) and the EORTC QOL Questionnaire Bone Metastases module (QLQ-BM22). RESULTS: Age and sex were not significantly associated with QOL. Worse performance status, higher pain scores, and opioid and single-fraction use were significantly associated with most QOL scales; these four factors were associated with worse global QOL, worse functioning status, and more severe symptoms. The coefficients of determination for most QOL scales were less than 0.2, indicating that most of the variability in QOL scores was not explained by any of the explanatory variables. CONCLUSION: Performance status, pain intensity, and opioid and single-fraction use were significantly associated with most QOL scales. However, the associations were not strong enough to estimate QOL. ADVANCES IN KNOWLEDGE: To date, the association between treatment factors and QOL in patients with bone metastases has not been fully studied. We identified the factors that were significantly associated with QOL and found that these associations were not strong enough to predict QOL.

Income and Employment of Patients at the Start of and During Follow-up After Palliative Radiation Therapy for Bone Metastasis
Hiroki Shirato, Hideyuki Harada, Yukako Iwasaki, Akifumi Notsu, Kazunari Yamada, Haruka Uezono, Yutaro Koide, Hitoshi Wada, Hikaru Kubota, Naoto Shikama, Takuya Yamazaki, Kei Ito, Joichi Heianna, Yukinori Okada, Ayako Tonari, Shigeo Takahashi, Takashi Kosugi, Yasuo Ejima, Norio Katoh, Kayo Yoshida, Takafumi Komiyama, Nobue Uchida, Misako Miwa, Miho Watanabe, Hisayasu Nagakura, Tetsuo Saito, Hiroko Ikeda, Isao Asakawa, Tateishi Seiichiro, Takeo Takahashi, Naoyuki Shigematsu
Advances in Radiation Oncology, 8, 4, 101205, 101205, Elsevier BV, Jul. 2023
Scientific journal

Machine learning-based normal tissue complication probability model for predicting albumin-bilirubin (ALBI) grade increase in hepatocellular carcinoma patients
Anussara Prayongrat, Natchalee Srimaneekarn, Kanokporn Thonglert, Chonlakiet Khorprasert, Napapat Amornwichet, Petch Alisanant, Hiroki Shirato, Keiji Kobashi, Sira Sriswasdi
Radiation Oncology, 17, 1, Springer Science and Business Media LLC, 07 Dec. 2022, [Peer-reviewed]
Scientific journal, Abstract

Purpose:

The aim of this study was to develop a normal tissue complication probability model using a machine learning approach (ML-based NTCP) to predict the risk of radiation-induced liver disease in hepatocellular carcinoma (HCC) patients.

Materials and methods:

The study population included 201 HCC patients treated with radiotherapy. The patients’ medical records were retrospectively reviewed to obtain the clinical and radiotherapy data. Toxicity was defined by albumin-bilirubin (ALBI) grade increase. The normal liver dose-volume histogram was reduced to mean liver dose (MLD) based on the fraction size-adjusted equivalent uniform dose (2 Gy/fraction and α/β = 2). Three types of ML-based classification models were used, a penalized logistic regression (PLR), random forest (RF), and gradient-boosted tree (GBT) model. Model performance was compared using the area under the receiver operating characteristic curve (AUROC). Internal validation was performed by 5-fold cross validation and external validation was done in 44 new patients.

Results:

Liver toxicity occurred in 87 patients (43.1%). The best individual model was the GBT model using baseline liver function, liver volume, and MLD as inputs and the best overall model was an ensemble of the PLR and GBT models. An AUROC of 0.82 with a standard deviation of 0.06 was achieved for the internal validation. An AUROC of 0.78 with a standard deviation of 0.03 was achieved for the external validation. The behaviors of the best GBT model were also in good agreement with the domain knowledge on NTCP.

Conclusion:

We propose the methodology to develop an ML-based NTCP model to estimate the risk of ALBI grade increase.

Injectable Fiducial Marker for Image-Guided Radiation Therapy Based on Gold Nanoparticles and a Body Temperature-Activated Gel-Forming System
Haoran Liu, Naoki Miyamoto, Mai Thanh Nguyen, Hiroki Shirato, Tetsu Yonezawa
ACS Applied Bio Materials, 08 Sep. 2022, [Peer-reviewed], [International Magazine]
Scientific journal

A real-time measurement system for gene expression rhythms from deep tissues of freely moving mice under light-dark conditions.
Nakaya M, Wakamatsu M, Motegi H, Ami Tanaka A, Sutherland K, Ishikawa M, Ozaki M, Shirato H, Hamada K, Hamada T* (* Correspondence).
Biochemistry and Biophysics Reports, 32, 101344, 101344, Sep. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Clock gene expression in most organs of the living body exhibits a diurnal rhythm synchronized with the external 24 h light-dark (LD) cycle via circadian pacemaker suprachiasmatic nucleus (SCN). Disturbances in clock gene expression due to desynchronization of clock gene expression of the external LD cycle are risk factors for developing various diseases. Measuring the in vivo clock genes expression rhythm for a long duration under LD conditions can greatly contribute to understand the pathogenic mechanism of the disease caused by the disturbance of the biological rhythm. However, it is presently difficult to continuously measure gene expression for a long duration under LD conditions. In present study, we succeeded in measuring Period1 (Per1) gene expression under LD conditions using ultraviolet (UV) light with filter cut the visible light range. In addition, we succeeded in measuring the kinetic change of liver Per1 gene expression during the process of desynchronization of behavioral rhythm from the LD cycle by chronic administration of methamphetamine (MAP). In the future, by using this system to measure clock gene expression rhythms of brain tissues such as SCN and peripheral tissues under LD conditions, it could contribute to understand the onset mechanism of diseases induced by the desynchronization mechanism of biological rhythm to the LD cycle.

A Consistent Protocol Reveals a Large Heterogeneity in the Biological Effectiveness of Proton and Carbon-Ion Beams for Various Sarcoma and Normal-Tissue-Derived Cell Lines.
Masashi Yagi, Yutaka Takahashi, Kazumasa Minami, Taeko Matsuura, Jin-Min Nam, Yasuhito Onodera, Takashi Akagi, Takuya Maeda, Tomoaki Okimoto, Hiroki Shirato, Kazuhiko Ogawa
Cancers, 14, 8, 15 Apr. 2022, [International Magazine]
English, Scientific journal, This study investigated variations in the relative biological effectiveness (RBE) values among various sarcoma and normal-tissue-derived cell lines (normal cell line) in proton beam and carbon-ion irradiations. We used a consistent protocol that specified the timing of irradiation after plating cells and detailed the colony formation assay. We examined the cell type dependence of RBE for proton beam and carbon-ion irradiations using four human sarcoma cell lines (MG63 osteosarcoma, HT1080 fibrosarcoma, SW872 liposarcoma, and SW1353 chondrosarcoma) and three normal cell lines (HDF human dermal fibroblast, hTERT-HME1 mammary gland, and NuLi-1 bronchus epithelium). The cells were irradiated with gamma rays, proton beams at the center of the spread-out Bragg peak, or carbon-ion beams at 54.4 keV/μm linear energy transfer. In all sarcoma and normal cell lines, the average RBE values in proton beam and carbon-ion irradiations were 1.08 ± 0.11 and 2.08 ± 0.36, which were consistent with the values of 1.1 and 2.13 used in current treatment planning systems, respectively. Up to 34% difference in the RBE of the proton beam was observed between MG63 and HT1080. Similarly, a 32% difference in the RBE of the carbon-ion beam was observed between SW872 and the other sarcoma cell lines. In proton beam irradiation, normal cell lines had less variation in RBE values (within 10%), whereas in carbon-ion irradiation, RBE values differed by up to 48% between hTERT-HME1 and NuLi-1. Our results suggest that specific dose evaluations for tumor and normal tissues are necessary for treatment planning in both proton and carbon-ion therapies.

Preparation of Biopex-Supported Gold Nanoparticles as Potential Fiducial Markers for Image-Guided Radiation Therapy.
Kai Ikeda, Haoran Liu, Naoki Miyamoto, Mai Thanh Nguyen, Hiroki Shirato, Tetsu Yonezawa
ACS applied bio materials, 5, 3, 1259, 1266, 21 Mar. 2022, [International Magazine]
English, Scientific journal, Image-guided radiation therapy (IGRT) has emerged as a promising technique for cancer treatment to improve radiation precision and accuracy, thereby reducing the treatment toxicity and optimizing therapeutic efficacy. In IGRT, fiducial markers are required to be inserted near the tumor to get the spatial information of the tumor. Currently used metal fiducial markers with large sizes would be highly invasive; therefore, it is critical to develop minimally invasive alternatives to these markers. In this work, an injectable marker based on Biopex-supported Au NPs with adequate radio-opacity for X-ray visualization was developed. Biopex can function as a substrate for the growth of Au NPs and avoid excessive reaction-induced aggregation and precipitation. The self-curing property of Biopex prevents the leakage and elimination of isolated Au NPs, enabling long-term X-ray observation and radiotherapy. The effect of Biopex amount, gold precursor concentration, and reaction time were evaluated. The visibility of samples prepared by the optimized formula was also examined. The developed Biopex-Au NPs could be injected through a 21 G needle and exhibit great visibility in the X-ray visualization test, showing great potential as a fiducial marker for image-guided radiation therapy.

Dosimetric advantages of daily adaptive strategy in IMPT for high-risk prostate cancer.
Hiroshi Tamura, Keiji Kobashi, Kentaro Nishioka, Takaaki Yoshimura, Takayuki Hashimoto, Shinichi Shimizu, Yoichi M Ito, Yoshikazu Maeda, Makoto Sasaki, Kazutaka Yamamoto, Hiroyasu Tamamura, Hidefumi Aoyama, Hiroki Shirato
Journal of applied clinical medical physics, 23, 4, e13531, 19 Jan. 2022, [International Magazine]
English, Scientific journal, PURPOSE: To evaluate the dosimetric advantages of daily adaptive radiotherapy (DART) in intensity-modulated proton therapy (IMPT) for high-risk prostate cancer by comparing estimated doses of the conventional non-adaptive radiotherapy (NART) that irradiates according to an original treatment plan through the entire treatment and the DART that uses an adaptive treatment plan generated by using daily CT images acquired before each treatment. METHODS: Twenty-three patients with prostate cancer were included. A treatment plan with 63 Gy (relative biological effectiveness (RBE)) in 21 fractions was generated using treatment planning computed tomography (CT) images assuming that all patients had high-risk prostate cancer for which the clinical target volume (CTV) needs to include prostate and the seminal vesicle (SV) in our treatment protocol. Twenty-one adaptive treatment plans for each patient (total 483 data sets) were generated using daily CT images, and dose distributions were calculated. Using a 3 mm set-up uncertainty in the robust optimization, the doses to the CTV, prostate, SV, rectum, and bladder were compared. RESULTS: Estimated accumulated doses of NART and DART in the 23 patients were 60.81 ± 3.47 Gy (RBE) and 63.24 ± 1.04 Gy (RBE) for CTV D99 (p < 0.01), 62.99 ± 1.28 Gy (RBE) and 63.43 ± 1.33 Gy (RBE) for the prostate D99 (p = 0.2529), and 59.07 ± 5.19 Gy (RBE) and 63.17 ± 1.04 Gy (RBE) for SV D99 (p < 0.001). No significant differences were observed between NART and DART in the estimated accumulated dose for the rectum and bladder. CONCLUSION: Compared with the NART, DART was shown to be a useful approach that can maintain the dose coverage to the target without increasing the dose to the organs at risk (OAR) using the 3 mm set-up uncertainty in the robust optimization in patients with high-risk prostate cancer.

Green and effective synthesis of gold nanoparticles as an injectable fiducial marker for real-time image gated proton therapy
Haoran Liu, Naoki Miyamoto, Mai Thanh Nguyen, Hiroki Shirato, Tetsu Yonezawa
Materials Advances, Royal Society of Chemistry ({RSC}), 2022
Scientific journal

Prediction of liver Dmean for proton beam therapy using deep learning and contour-based data augmentation
Sira Jampa-ngern, Keiji Kobashi, Shinichi Shimizu, Seishin Takao, Keiji Nakazato, Hiroki Shirato
Journal of Radiation Research, Oxford University Press (OUP), 06 Oct. 2021
Scientific journal, Abstract

The prediction of liver Dmean with 3-dimensional radiation treatment planning (3DRTP) is time consuming in the selection of proton beam therapy (PBT), and deep learning prediction generally requires large and tumor-specific databases. We developed a simple dose prediction tool (SDP) using deep learning and a novel contour-based data augmentation (CDA) approach and assessed its usability. We trained the SDP to predict the liver Dmean immediately. Five and two computed tomography (CT) data sets of actual patients with liver cancer were used for the training and validation. Data augmentation was performed by artificially embedding 199 contours of virtual clinical target volume (CTV) into CT images for each patient. The data sets of the CTVs and OARs are labeled with liver Dmean for six different treatment plans using two-dimensional calculations assuming all tissue densities as 1.0. The test of the validated model was performed using 10 unlabeled CT data sets of actual patients. Contouring only of the liver and CTV was required as input. The mean relative error (MRE), the mean percentage error (MPE) and regression coefficient between the planned and predicted Dmean was 0.1637, 6.6%, and 0.9455, respectively. The mean time required for the inference of liver Dmean of the six different treatment plans for a patient was 4.47±0.13 seconds. We conclude that the SDP is cost-effective and usable for gross estimation of liver Dmean in the clinic although the accuracy should be improved further if we need the accuracy of liver Dmean to be compatible with 3DRTP.

Prediction of target position from multiple fiducial markers by partial least squares regression in real-time tumor-tracking radiation therapy.
Kanako Ukon, Yohei Arai, Seishin Takao, Taeko Matsuura, Masayori Ishikawa, Hiroki Shirato, Shinichi Shimizu, Kikuo Umegaki, Naoki Miyamoto
Journal of radiation research, 62, 5, 926, 933, 13 Sep. 2021, [International Magazine]
English, Scientific journal, The purpose of this work is to show the usefulness of a prediction method of tumor location based on partial least squares regression (PLSR) using multiple fiducial markers. The trajectory data of respiratory motion of four internal fiducial markers inserted in lungs were used for the analysis. The position of one of the four markers was assumed to be the tumor position and was predicted by other three fiducial markers. Regression coefficients for prediction of the position of the tumor-assumed marker from the fiducial markers' positions is derived by PLSR. The tracking error and the gating error were evaluated assuming two possible variations. First, the variation of the position definition of the tumor and the markers on treatment planning computed tomograhy (CT) images. Second, the intra-fractional anatomical variation which leads the distance change between the tumor and markers during the course of treatment. For comparison, rigid predictions and ordinally multiple linear regression (MLR) predictions were also evaluated. The tracking and gating errors of PLSR prediction were smaller than those of other prediction methods. Ninety-fifth percentile of tracking/gating error in all trials were 3.7/4.1 mm, respectively in PLSR prediction for superior-inferior direction. The results suggested that PLSR prediction was robust to variations, and clinically applicable accuracy could be achievable for targeting tumors.

Radiological tumour classification across imaging modality and histology
Jia Wu, Chao Li, Michael Gensheimer, Sukhmani Padda, Fumi Kato, Hiroki Shirato, Yiran Wei, Carola-Bibiane Schönlieb, Stephen John Price, David Jaffray, John Heymach, Joel W. Neal, Billy W. Loo, Heather Wakelee, Maximilian Diehn, Ruijiang Li
Nature Machine Intelligence, 3, 9, 787, 798, Springer Science and Business Media LLC, Sep. 2021
Scientific journal

Validation of dose distribution for liver tumors treated with real-time-image gated spot-scanning proton therapy by log data based dose reconstruction.
Takahiro Yamada, Seishin Takao, Hidenori Koyano, Hideaki Nihongi, Yusuke Fujii, Shusuke Hirayama, Naoki Miyamoto, Taeko Matsuura, Kikuo Umegaki, Norio Katoh, Isao Yokota, Hiroki Shirato, Shinichi Shimizu
Journal of radiation research, 62, 4, 626, 633, 10 Jul. 2021, [International Magazine]
English, Scientific journal, In spot scanning proton therapy (SSPT), the spot position relative to the target may fluctuate through tumor motion even when gating the radiation by utilizing a fiducial marker. We have established a procedure that evaluates the delivered dose distribution by utilizing log data on tumor motion and spot information. The purpose of this study is to show the reliability of the dose distributions for liver tumors treated with real-time-image gated SSPT (RGPT). In the evaluation procedure, the delivered spot information and the marker position are synchronized on the basis of log data on the timing of the spot irradiation and fluoroscopic X-ray irradiation. Then a treatment planning system reconstructs the delivered dose distribution. Dose distributions accumulated for all fractions were reconstructed for eight liver cases. The log data were acquired in all 168 fractions for all eight cases. The evaluation was performed for the values of maximum dose, minimum dose, D99, and D5-D95 for the clinical target volumes (CTVs) and mean liver dose (MLD) scaled by the prescribed dose. These dosimetric parameters were statistically compared between the planned dose distribution and the reconstructed dose distribution. The mean difference of the maximum dose was 1.3% (95% confidence interval [CI]: 0.6%-2.1%). Regarding the minimum dose, the mean difference was 0.1% (95% CI: -0.5%-0.7%). The mean differences of D99, D5-D95 and MLD were below 1%. The reliability of dose distributions for liver tumors treated with RGPT-SSPT was shown by the evaluation of the accumulated dose distributions.

Fundamental study on quality assurance (QA) procedures for a real-time tumor tracking radiotherapy (RTRT) system from the viewpoint of imaging devices.
Suguru Kimura, Naoki Miyamoto, Kenneth L Sutherland, Ryusuke Suzuki, Hiroki Shirato, Masayori Ishikawa
Journal of applied clinical medical physics, 22, 7, 165, 176, Jul. 2021, [International Magazine]
English, Scientific journal, PURPOSE: The real-time tumor tracking radiotherapy (RTRT) system requires periodic quality assurance (QA) and quality control. The goal of this study is to propose QA procedures from the viewpoint of imaging devices in the RTRT system. METHODS: Tracking by the RTRT system (equips two sets of colored image intensifiers (colored I.I.s) fluoroscopy units) for the moving gold-marker (diameter 2.0 mm) in a rotating phantom were performed under various X-ray conditions. To analyze the relationship between fluoroscopic image quality and precision of gold marker coordinate calculation, the standard deviation of the 3D coordinate (σ3D [mm]) of the gold marker, the mean of the pattern recognition score (PRS) and the standard deviation of the distance between rays (DBR) (σDBR [mm]) were evaluated. RESULTS: When tracking with speed of 10-60 mm/s, σDBR increased, though the mean PRS did not change significantly (p>0.05). On the contrary, the mean PRS increased depending on the integral noise equivalent quanta (∫NEQ) that is an indicator of image quality calculated from the modulation transfer function (MTF) as an indicator of spatial resolution and the noise power spectrum (NPS) as an indicator of noise characteristic. CONCLUSION: The indicators of NEQ, MTF, and NPS were useful for managing the tracking accuracy of the RTRT system. We propose observing the change of these indicators as additional QA procedures for each imaging device from the commissioning baseline.

Period1 gene expression in the olfactory bulb and liver of freely moving streptozotocin-treated diabetic mouse.
Harumi Kanou, Kouki Nagasawa, Yuki Ishii, Aya Chishima, Juri Hayashi, Sanae Haga, Kenneth Sutherland, Masayori Ishikawa, Michitaka Ozaki, Hiroki Shirato, Kazuko Hamada, Toshiyuki Hamada
Biochemical and biophysical research communications, 560, 14, 20, 30 Jun. 2021, [International Magazine]
English, Scientific journal, Clock genes express circadian rhythms in most organs. These rhythms are organized throughout the whole body, regulated by the suprachiasmatic nucleus (SCN) in the brain. Disturbance of these clock gene expression rhythms is a risk factor for diseases such as obesity. In the present study, to explore the role of clock genes in developing diabetes, we examined the effect of streptozotocin (STZ)-induced high glucose on Period1 (Per1) gene expression rhythm in the liver and the olfactory bub (OB) in the brain. We found a drastic increase of Per1 expression in both tissues after STZ injection while blood glucose content was low. After a rapid expression peak, Per1 expression showed no rhythm. Associated with an increase of glucose content, behavior became arrhythmic. Finally, we succeeded in detecting an increase of Per1 expression in mice hair follicles on day 1 after STZ administration, before the onset of symptoms. These results show that elevated Per1 expression by STZ plays an important role in the aggravation of diabetes.

Assessment of the confidence interval in the multivariable normal tissue complication probability model for predicting radiation-induced liver disease in primary liver cancer.
Anussara Prayongrat, Natchalee Srimaneekarn, Sira Sriswasdi, Yoichi M Ito, Norio Katoh, Masaya Tamura, Yasuhiro Dekura, Chie Toramatsu, Chonlakiet Khorprasert, Napapat Amornwichet, Petch Alisanant, Yuichi Hirata, Anthony Hayter, Hiroki Shirato, Shinichi Shimizu, Keiji Kobashi
Journal of radiation research, 62, 3, 483, 493, 12 May 2021, [International Magazine]
English, Scientific journal, We developed a confidence interval-(CI) assessing model in multivariable normal tissue complication probability (NTCP) modeling for predicting radiation-induced liver disease (RILD) in primary liver cancer patients using clinical and dosimetric data. Both the mean NTCP and difference in the mean NTCP (ΔNTCP) between two treatment plans of different radiotherapy modalities were further evaluated and their CIs were assessed. Clinical data were retrospectively reviewed in 322 patients with hepatocellular carcinoma (n = 215) and intrahepatic cholangiocarcinoma (n = 107) treated with photon therapy. Dose-volume histograms of normal liver were reduced to mean liver dose (MLD) based on the fraction size-adjusted equivalent uniform dose. The most predictive variables were used to build the model based on multivariable logistic regression analysis with bootstrapping. Internal validation was performed using the cross-validation leave-one-out method. Both the mean NTCP and the mean ΔNTCP with 95% CIs were calculated from computationally generated multivariate random sets of NTCP model parameters using variance-covariance matrix information. RILD occurred in 108/322 patients (33.5%). The NTCP model with three clinical and one dosimetric parameter (tumor type, Child-Pugh class, hepatitis infection status and MLD) was most predictive, with an area under the receiver operative characteristics curve (AUC) of 0.79 (95% CI 0.74-0.84). In eight clinical subgroups based on the three clinical parameters, both the mean NTCP and the mean ΔNTCP with 95% CIs were able to be estimated computationally. The multivariable NTCP model with the assessment of 95% CIs has potential to improve the reliability of the NTCP model-based approach to select the appropriate radiotherapy modality for each patient.

Calibrated uncertainty estimation for interpretable proton computed tomography image correction using Bayesian deep learning.
Yusuke Nomura, Sodai Tanaka, Jeff Wang, Hiroki Shirato, Shinichi Shimizu, Lei Xing
Physics in medicine and biology, 66, 6, 065029, 065029, 16 Mar. 2021, [International Magazine]
English, Scientific journal, Integrated-type proton computed tomography (pCT) measures proton stopping power ratio (SPR) images for proton therapy treatment planning, but its image quality is degraded due to noise and scatter. Although several correction methods have been proposed, techniques that include estimation of uncertainty are limited. This study proposes a novel uncertainty-aware pCT image correction method using a Bayesian convolutional neural network (BCNN). A DenseNet-based BCNN was constructed to predict both a corrected SPR image and its uncertainty from a noisy SPR image. A total 432 noisy SPR images of 6 non-anthropomorphic and 3 head phantoms were collected with Monte Carlo simulations, while true noise-free images were calculated with known geometric and chemical components. Heteroscedastic loss and deep ensemble techniques were performed to estimate aleatoric and epistemic uncertainties by training 25 unique BCNN models. 200-epoch end-to-end training was performed for each model independently. Feasibility of the predicted uncertainty was demonstrated after applying two post-hoc calibrations and calculating spot-specific path length uncertainty distribution. For evaluation, accuracy of head SPR images and water-equivalent thickness (WET) corrected by the trained BCNN models was compared with a conventional method and non-Bayesian CNN model. BCNN-corrected SPR images represent noise-free images with high accuracy. Mean absolute error in test data was improved from 0.263 for uncorrected images to 0.0538 for BCNN-corrected images. Moreover, the calibrated uncertainty represents accurate confidence levels, and the BCNN-corrected calibrated WET was more accurate than non-Bayesian CNN with high statistical significance. Computation time for calculating one image and its uncertainties with 25 BCNN models is 0.7 s with a consumer grade GPU. Our model is able to predict accurate pCT images as well as two types of uncertainty. These uncertainties will be useful to identify potential cause of SPR errors and develop a spot-specific range margin criterion, toward elaboration of uncertainty-guided proton therapy.

Analysis of acute-phase toxicities of intensity-modulated proton therapy using a model-based approach in pharyngeal cancer patients.
Koichi Yasuda, Hideki Minatogawa, Yasuhiro Dekura, Seishin Takao, Masaya Tamura, Nayuta Tsushima, Takayoshi Suzuki, Satoshi Kano, Takatsugu Mizumachi, Takashi Mori, Kentaro Nishioka, Motoyasu Shido, Norio Katoh, Hiroshi Taguchi, Noriyuki Fujima, Rikiya Onimaru, Isao Yokota, Keiji Kobashi, Shinichi Shimizu, Akihiro Homma, Hiroki Shirato, Hidefumi Aoyama
Journal of radiation research, 62, 2, 329, 337, 10 Mar. 2021, [International Magazine]
English, Scientific journal, Pharyngeal cancer patients treated with intensity-modulated proton therapy (IMPT) using a model-based approach were retrospectively reviewed, and acute toxicities were analyzed. From June 2016 to March 2019, 15 pharyngeal (7 naso-, 5 oro- and 3 hypo-pharyngeal) cancer patients received IMPT with robust optimization. Simulation plans for IMPT and intensity-modulated X-ray therapy (IMXT) were generated before treatment. We also reviewed 127 pharyngeal cancer patients with IMXT in the same treatment period. In the simulation planning comparison, all of the normal-tissue complication probability values for dysphagia, dysgeusia, tube-feeding dependence and xerostomia were lower for IMPT than for IMXT in the 15 patients. After completing IMPT, 13 patients completed the evaluation, and 12 of these patients had a complete response. The proportions of patients who experienced grade 2 or worse acute toxicities in the IMPT and IMXT cohorts were 21.4 and 56.5% for dysphagia (P < 0.05), 46.7 and 76.3% for dysgeusia (P < 0.05), 73.3 and 62.8% for xerostomia (P = 0.43), 73.3 and 90.6% for mucositis (P = 0.08) and 66.7 and 76.4% for dermatitis (P = 0.42), respectively. Multivariate analysis revealed that IMPT was independently associated with a lower rate of grade 2 or worse dysphagia and dysgeusia. After propensity score matching, 12 pairs of IMPT and IMXT patients were selected. Dysphagia was also statistically lower in IMPT than in IMXT (P < 0.05). IMPT using a model-based approach may have clinical benefits for acute dysphagia.

Stability of d-luciferin for bioluminescence to detect gene expression in freely moving mice for long durations.
Kanako Nakajima, Kazuko Hamada, Ryoga Ito, Yukina Yoshida, Kenneth Sutherland, Masayori Ishikawa, Michitaka Ozaki, Hiroki Shirato, Toshiyuki Hamada
Luminescence : the journal of biological and chemical luminescence, 36, 1, 94, 98, Feb. 2021, [International Magazine]
English, Scientific journal, Circadian disturbance of clock gene expression is a risk factor for diseases such as obesity, cancer, and sleep disorders. To study these diseases, it is necessary to monitor and analyze the expression rhythm of clock genes in the whole body for a long duration. The bioluminescent reporter enzyme firefly luciferase and its substrate d-luciferin have been used to generate optical signals from tissues in vivo with high sensitivity. However, little information is known about the stability of d-luciferin to detect gene expression in living animals for a long duration. In the present study, we examined the stability of a luciferin solution over 21 days. l-Luciferin, which is synthesized using racemization of d-luciferin, was at high concentrations after 21 days. In addition, we showed that bioluminescence of Period1 (Per1) expression in the liver was significantly decreased compared with the day 1 solution, although locomotor activity rhythm was not affected. These results showed that d-luciferin should be applied to the mouse within, at most, 7 days to detect bioluminescence of Per1 gene expression rhythm in vivo.

The role of endoscopic resection for selected patients with sinonasal squamous cell carcinoma.
Yuji Nakamaru, Masanobu Suzuki, Satoshi Kano, Takatsugu Mizumachi, Nayuta Tsushima, Takayoshi Suzuki, Aya Honma, Akira Nakazono, Shogo Kimura, Rikiya Onimaru, Koichi Yasuda, Hiroki Shirato, Akihiro Homma
Auris, nasus, larynx, 48, 1, 131, 137, Feb. 2021, [International Magazine]
English, Scientific journal, OBJECTIVE: Despite of rapid advances in endoscopic surgery, the gold standard for sinonasal squamous cell carcinoma (SNSCC) surgery has remained the open approach with en-block resection due to the aggressive nature of SNSCC, including frequent recurrence and high mortality rate. For that reason, few studies have focused on SNSCC treated by endoscopic surgery alone. The objective of this study was to evaluate the usefulness of endoscopic surgery for patients with SNSCC. METHODS: A retrospective analysis was performed for 15 consecutive SNSCC patients who underwent endoscopic surgery without an open approach. We carefully selected patients whose tumor attachment sites could be fully visualized and completely resected through an endonasal approach. RESULTS: Of the fifteen patients, 4 patients (27%) were diagnosed with T1, 7 (47%) with T2, 4 (27%) with T3, and no patients with T4a or T4b disease. Four of the 15 (27%) patients showed positive surgical margins. The 5-yr overall survival, disease-specific survival, and local control rate was 72.4%, 79.6%, and 92.9%, respectively. The 5-yr disease-specific survival for T1, T2, and T3 disease was 100% and 75% and 75%, respectively. Patients with negative surgical margins had a better disease-specific survival rate than did those with positive surgical margins (p = 0.0253). CONCLUSION: Endoscopic surgery for patients with SNSCC appears to afford an effective method in selected cases. The achievement of negative surgical margins with a good view of the tumor attachment site was considered to be critical to the management of SNSCC.

Multiparametric Analysis of Tumor Morphological and Functional MR Parameters Potentially Predicts Local Failure in Pharynx Squamous Cell Carcinoma Patients.
Noriyuki Fujima, Yukie Shimizu, Daisuke Yoshida, Satoshi Kano, Takatsugu Mizumachi, Akihiro Homma, Koichi Yasuda, Rikiya Onimaru, Osamu Sakai, Kohsuke Kudo, Hiroki Shirato
The journal of medical investigation : JMI, 68, 3.4, 354, 361, 2021, [Domestic magazines]
English, Scientific journal, Purpose : To predict local control / failure by a multiparametric approach using magnetic resonance (MR)-derived tumor morphological and functional parameters in pharynx squamous cell carcinoma (SCC) patients. Materials and Methods : Twenty-eight patients with oropharyngeal and hypopharyngeal SCCs were included in this study. Quantitative morphological parameters and intratumoral characteristics on T2-weighted images, tumor blood flow from pseudo-continuous arterial spin labeling, and tumor diffusion parameters of three diffusion models from multi-b-value diffusion-weighted imaging as well as patients' characteristics were analyzed. The patients were divided into local control / failure groups. Univariate and multiparametric analysis were performed for the patient group division. Results : The value of morphological parameter of 'sphericity' and intratumoral characteristic of 'homogeneity' was revealed respectively significant for the prediction of the local control status in univariate analysis. Higher diagnostic performance was obtained with the sensitivity of 0.8, specificity of 0.75, positive predictive value of 0.89, negative predictive value of 0.6 and accuracy of 0.79 by multiparametric diagnostic model compared to results in the univariate analysis. Conclusion : A multiparametric analysis with MR-derived quantitative parameters may be useful to predict local control in pharynx SCC patients. J. Med. Invest. 68 : 354-361, August, 2021.

Are simple verbal instructions sufficient to ensure that bladder volume does not deteriorate prostate position reproducibility during spot scanning proton therapy?
Kentaro Nishioka, Kento Gotoh, Takayuki Hashimoto, Takashige Abe, Takahiro Osawa, Ryuji Matsumoto, Isao Yokota, Norio Katoh, Rumiko Kinoshita, Koichi Yasuda, Toshiaki Yakabe, Takaaki Yoshimura, Seishin Takao, Nobuo Shinohara, Hidefumi Aoyama, Shinichi Shimizu, Hiroki Shirato
BJR|Open, 3, 1, British Institute of Radiology, Jan. 2021
Scientific journal, The purpose of this study is to investigate whether verbal instructions are sufficient for bladder volume (BV) control not to deteriorate prostate position reproducibility in image-guided spot scanning proton therapy (SSPT) for localized prostate cancer.

A total of 268 treatment sessions in 12 consecutive prostate cancer patients who were treated with image-guided SSPT with fiducial markers were retrospectively analyzed. In addition to strict rectal volume control procedures, simple verbal instructions to void urine one hour before the treatment were used here. The BV was measured by a Bladder Scan just before the treatment, and the prostate motion was measured by intraprostatic fiducial markers and two sets of X-ray fluoroscopy images. The correlation between the BV change and prostate motion was assessed by linear mixed-effects models and systematic and random errors according to the reproducibility of the BV.

The mean absolute BV change during treatment was from −98.7 to 86.3 ml (median 7.1 ml). The mean absolute prostate motion of the patients in the left-right direction was −1.46 to 1.85 mm; in the cranial-caudal direction it was −6.10 to 3.65 mm, and in the anteroposterior direction −1.90 to 5.23 mm. There was no significant relationship between the BV change and prostate motion during SSPT. The early and late genitourinary and gastrointestinal toxicity was minimal with a minimum follow up of 4.57 years.

Simple verbal instructions about urination was suggested to be sufficient to control the BV not to impact on the prostate motion and clinical outcomes in image-guided SSPT. Careful attention to BV change is still needed when the seminal vesicle is to be treated.

Our data demonstrated that there was no apparent relationship between BV changes and prostate position reproducibility and simple verbal instruction about urination could be sufficient for image-guided SSPT.

Potential benefits of adaptive intensity-modulated proton therapy in nasopharyngeal carcinomas.
Hideki Minatogawa, Koichi Yasuda, Yasuhiro Dekura, Seishin Takao, Taeko Matsuura, Takaaki Yoshimura, Ryusuke Suzuki, Isao Yokota, Noriyuki Fujima, Rikiya Onimaru, Shinichi Shimizu, Hidefumi Aoyama, Hiroki Shirato
Journal of applied clinical medical physics, 22, 1, 174, 183, Jan. 2021, [International Magazine]
English, Scientific journal, PURPOSE: To investigate potential advantages of adaptive intensity-modulated proton beam therapy (A-IMPT) by comparing it to adaptive intensity-modulated X-ray therapy (A-IMXT) for nasopharyngeal carcinomas (NPC). METHODS: Ten patients with NPC treated with A-IMXT (step and shoot approach) and concomitant chemotherapy between 2014 and 2016 were selected. In the actual treatment, 46 Gy in 23 fractions (46Gy/23Fx.) was prescribed using the initial plan and 24Gy/12Fx was prescribed using an adapted plan thereafter. New treatment planning of A-IMPT was made for the same patients using equivalent dose fractionation schedule and dose constraints. The dose volume statistics based on deformable images and dose accumulation was used in the comparison of A-IMXT with A-IMPT. RESULTS: The means of the Dmean of the right parotid gland (P < 0.001), right TM joint (P < 0.001), left TM joint (P < 0.001), oral cavity (P < 0.001), supraglottic larynx (P = 0.001), glottic larynx (P < 0.001), , middle PCM (P = 0.0371), interior PCM (P < 0.001), cricopharyngeal muscle (P = 0.03643), and thyroid gland (P = 0.00216), in A-IMPT are lower than those of A-IMXT, with statistical significance. The means of, D0.03cc , and Dmean of each sub portion of auditory apparatus and D30% for Eustachian tube and D0.5cc for mastoid volume in A-IMPT are significantly lower than those of A-IMXT. The mean doses to the oral cavity, supraglottic larynx, and glottic larynx were all reduced by more than 20 Gy (RBE = 1.1). CONCLUSIONS: An adaptive approach is suggested to enhance the potential benefit of IMPT compared to IMXT to reduce adverse effects for patients with NPC.

Mouse period1 gene expression recording from olfactory bulb under free moving conditions with a portable optic fibre device.
Ryoga Ito, Kazuko Hamada, Shigeru Kasahara, Yoshihiro Kikuchi, Kanako Nakajima, Kenneth Sutherland, Hiroki Shirato, Michitaka Ozaki, Masayori Ishikawa, Toshiyuki Hamada
Luminescence : the journal of biological and chemical luminescence, 35, 8, 1248, 1253, Dec. 2020, [International Magazine]
English, Scientific journal, Because the disruption of circadian clock gene is a risk factor in many diseases such as obesity and cancer, it is important to monitor and analyzed the expression of the rhythm of the clock gene throughout the body over a long period of time. Although we previously reported on a new gene expression analysis system tracking a target position on the body surface of freely moving mice, the experimental apparatus required a large space. We have therefore developed an in vivo recording system using a portable photomultiplier tube (PMT) system attached to an optical fibre. Directly connecting the target area with the device, we could easily measure the photon counts in a very small space. However, little information is known about the characteristics of optical fibres when exposed to twisting/looping in association with a moving mouse and the effect of the surface of optical fibre. In the present study, we report on the characteristics of optical fibres to detect gene expression rhythm in freely moving mice. Using this portable optical device directly connected with a target area, we were able to measure the circadian rhythm of clock gene expression over a prolonged period in freely moving mice in a small space.

Lysosomal trafficking mediated by Arl8b and BORC promotes invasion of cancer cells that survive radiation
Ping-Hsiu Wu, Yasuhito Onodera, Amato J. Giaccia, Quynh-Thu Le, Shinichi Shimizu, Hiroki Shirato, Jin-Min Nam
Communications Biology, 3, 1, Springer Science and Business Media LLC, Dec. 2020
Scientific journal, Enhanced invasiveness, a critical determinant of metastasis and poor prognosis, has been observed in cancer cells that survive cancer therapy, including radiotherapy. Here, we show that invasiveness in radiation-surviving cancer cells is associated with alterations in lysosomal exocytosis caused by the enhanced activation of Arl8b, a small GTPase that regulates lysosomal trafficking. The binding of Arl8b with its effector, SKIP, is increased after radiation through regulation of BORC-subunits. Knockdown of Arl8b or BORC-subunits decreases lysosomal exocytosis and the invasiveness of radiation-surviving cells. Notably, high expression ofARL8Band BORC-subunit genes is significantly correlated with poor prognosis in breast cancer patients. Sp1, an ATM-regulated transcription factor, is found to increase BORC-subunit genes expression after radiation. In vivo experiments show that ablation of Arl8b decreases IR-induced invasive tumor growth and distant metastasis. These findings suggest that BORC-Arl8b-mediated lysosomal trafficking is a target for improving radiotherapy by inhibiting invasive tumor growth and metastasis.

Quantitative analysis of treatments using real-time image gated spot-scanning with synchrotron-based proton beam therapy system log data.
Takaaki Yoshimura, Shinichi Shimizu, Takayuki Hashimoto, Kentaro Nishioka, Norio Katoh, Hiroshi Taguchi, Koichi Yasuda, Taeko Matsuura, Seishin Takao, Masaya Tamura, Sodai Tanaka, Yoichi M Ito, Yuto Matsuo, Hiroshi Tamura, Kenji Horita, Kikuo Umegaki, Hiroki Shirato
Journal of applied clinical medical physics, 21, 12, 10, 19, Dec. 2020, [International Magazine]
English, Scientific journal, A synchrotron-based real-time image gated spot-scanning proton beam therapy (RGPT) system with inserted fiducial markers can irradiate a moving tumor with high accuracy. As gated treatments increase the beam delivery time, this study aimed to investigate the frequency of intra-field adjustments corresponding to the baseline shift or drift and the beam delivery efficiency of a synchrotron-based RGPT system. Data from 118 patients corresponding to 127 treatment plans and 2810 sessions between October 2016 and March 2019 were collected. We quantitatively analyzed the proton beam delivery time, the difference between the ideal beam delivery time based on a simulated synchrotron magnetic excitation pattern and the actual treatment beam delivery time, frequency corresponding to the baseline shift or drift, and the gating efficiency of the synchrotron-based RGPT system according to the proton beam delivery machine log data. The mean actual beam delivery time was 7.1 min, and the simulated beam delivery time in an ideal environment with the same treatment plan was 2.9 min. The average difference between the actual and simulated beam delivery time per session was 4.3 min. The average frequency of intra-field adjustments corresponding to baseline shift or drift and beam delivery efficiency were 21.7% and 61.8%, respectively. Based on our clinical experience with a synchrotron-based RGPT system, we determined the frequency corresponding to baseline shift or drift and the beam delivery efficiency using the beam delivery machine log data. To maintain treatment accuracy within ± 2.0 mm, intra-field adjustments corresponding to baseline shift or drift were required in approximately 20% of cases. Further improvements in beam delivery efficiency may be realized by shortening the beam delivery time.

Fast spot-scanning proton dose calculation method with uncertainty quantification using a three-dimensional convolutional neural network
Yusuke Nomura, Jeff Wang, Hiroki Shirato, Shinichi Shimizu, Lei Xing
Physics in Medicine & Biology, {IOP} Publishing, 26 Oct. 2020, [Peer-reviewed]
Scientific journal

Double recording system of Period1 gene expression rhythm in the olfactory bulb and liver in freely moving mouse.
Kazuko Hamada, Akari Oota, Ryoga Ito, Shigeru Kasahara, Kanako Nakajima, Yoshihiro Kikuchi, Kenneth Sutherland, Masayori Ishikawa, Hiroki Shirato, Michitaka Ozaki, Toshiyuki Hamada
Biochemical and biophysical research communications, 529, 4, 898, 903, 03 Sep. 2020, [International Magazine]
English, Scientific journal, Clock genes express circadian rhythms in most organs. These rhythms are organized throughout the whole body, regulated by the suprachiasmatic nucleus (SCN) in the brain. Disturbance of these clock gene expression rhythms is a risk factor for diseases such as obesity and cancer. To understand the mechanism of regulating clock gene expression rhythms in vivo, multiple real time recording systems are required. In the present study, we developed a double recording system of Period1 expression rhythm in peripheral tissue (liver) and the brain. In peripheral tissue, quantification of gene expression in a steadily moving target was achieved by using a photomultiplier tube (PMT) attached to a tissue contact optical sensor (TCS). Using this technique, we were able to analyze circadian rhythms of clock gene expression over a prolonged period in the liver and olfactory bub (OB) of the brain. The present double recording system has no effect on behavioral activity or rhythm. Our novel system thus successfully quantifies clock gene expression in deep areas of the body in freely moving mice for a period sufficient to analyze circadian dynamics. In addition, our double recording system can be widely applied to many areas of biomedical research, as well as applications beyond medicine.

The impact of dose delivery time on biological effectiveness in proton irradiation with various biological parameters.
Koki Kasamatsu, Taeko Matsuura, Sodai Tanaka, Seishin Takao, Naoki Miyamoto, Jin-Min Nam, Hiroki Shirato, Shinichi Shimizu, Kikuo Umegaki
Medical physics, 47, 9, 4644, 4655, 11 Jul. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: The purpose of this study is to evaluate the sub-lethal damage (SLD) repair effect in prolonged proton irradiation using the biophysical model with various cell-specific parameters of (α/β)x and T1/2 (repair half time). At present, most of the model-based studies on protons have focused on acute radiation, neglecting the reduction in biological effectiveness due to SLD repair during the delivery of radiation. Nevertheless, the dose-rate dependency of biological effectiveness may become more important as advanced treatment techniques, such as hypofractionation and respiratory gating, come into clinical practice, as these techniques sometimes require long treatment times. Also, while previous research using the biophysical model revealed a large repair effect with a high physical dose, the dependence of the repair effect on cell-specific parameters has not been evaluated systematically. METHODS: Biological dose (relative biological effectiveness (RBE) × physical dose) calculation with repair included was carried out using the linear energy transfer (LET)-dependent linear-quadratic (LQ) model combined with the theory of dual radiation action (TDRA). First, we extended the dose protraction factor in the LQ model for the arbitrary number of different LET proton irradiations delivered sequentially with arbitrary time lags, referring to the TDRA. Using the LQ model, the decrease in biological dose due to SLD repair was systematically evaluated for spread-out Bragg peak (SOBP) irradiation in a water phantom with the possible ranges of both (α/β)x and repair parameters ((α/β)x = 1-15 Gy, T1/2 = 0-90 min). Then, to consider more realistic irradiation conditions, clinical cases of prostate, liver, and lung tumors were examined with the cell-specific parameters for each tumor obtained from the literature. Biological D99% and biological dose homogeneity coefficient (HC) were calculated for the clinical target volumes (CTVs), assuming dose-rate structures with a total irradiation time of 0-60 min. RESULTS: The differences in the cell-specific parameters resulted in considerable variation in the repair effect. The biological dose reduction found at the center of the SOBP with 30 min of continuous irradiation varied from 1.13% to 14.4% with a T1/2 range of 1-90 min when (α/β)x is fixed as 10 Gy. It varied from 2.3% to 6.8% with an (α/β)x range of 1-15 Gy for a fixed value of T1/2 = 30 min. The decrease in biological D99% per 10 min was 2.6, 1.2, and 3.0% for the prostate, liver, and lung tumor cases, respectively. The value of the biological D99% reduction was neither in the order of (α/β)x nor prescribed dose, but both comparably contributed to the repair effect. The variation of HC was within the range of 0.5% for all cases; therefore, the dose distribution was not distorted. CONCLUSION: The reduction in biological dose caused by the SLD repair largely depends on the cell-specific parameters in addition to the physical dose. The parameters should be considered carefully in the evaluation of the repair effect in prolonged proton irradiation.

Microstructural Alterations in Bipolar and Major Depressive Disorders: A Diffusion Kurtosis Imaging Study.
Daisuke Sawamura, Hisashi Narita, Naoki Hashimoto, Shin Nakagawa, Hiroyuki Hamaguchi, Noriyuki Fujima, Kohsuke Kudo, Hiroki Shirato, Khin K Tha
Journal of magnetic resonance imaging : JMRI, 23 Apr. 2020, [Peer-reviewed], [International Magazine]
English, BACKGROUND: Identifying structural and functional abnormalities in bipolar (BD) and major depressive disorders (MDD) is important for understanding biological processes. HYPOTHESIS: Diffusion kurtosis imaging (DKI) may be able to detect the brain's microstructural alterations in BD and MDD and any differences between the two. STUDY TYPE: Prospective. SUBJECTS: In all, 16 BD patients, 19 MDD patients, and 20 age- and gender-matched healthy volunteers. FIELD STRENGTH/SEQUENCE: DKI at 3.0T. ASSESSMENT: The major DKI indices of the brain were compared voxel-by-voxel among the three groups. Significantly different voxels were tested for correlation with clinical variables (ie, Young Mania Rating Scale [YMRS], 17-item Hamilton Depression Rating Scale [17-HDRS], Montgomery-Åsberg Depression Rating Scale, total disease duration, duration of current episode, and the number of past manic/depressive episodes). The performance of the DKI indices in identifying microstructural alterations was estimated. STATISTICAL TESTS: One-way analysis of variance (ANOVA) was used for group comparison of DKI indices. The performance of these indices in detecting microstructural alterations was determined by receiver operating characteristic (ROC) analysis. Pearson's product-moment correlation analyses were used to test the correlations of these indices with clinical variables. RESULTS: DKI revealed widespread microstructural alterations across the brain in each disorder (P < 0.05). Some were significantly different between the two disorders. Mean kurtosis (MK) in the gray matter of the right inferior parietal lobe was able to distinguish BD and MDD with an accuracy of 0.906. A strong correlation was revealed between MK in that region and YMRS in BD patients (r = -0.641, corrected P = 0.042) or 17-HDRS in MDD patients (r = -0.613, corrected P = 0.030). There were also strong correlations between a few other DKI indices and disease duration (r = -0.676 or 0.626, corrected P < 0.05). DATA CONCLUSION: DKI detected microstructural brain alterations in BD and MDD. Its indices may be useful to distinguish the two disorders or to reflect disease severity and duration. LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY STAGE: 3.

Dynamic gating window technique for the reduction of dosimetric error in respiratory-gated spot-scanning particle therapy: An initial phantom study using patient tumor trajectory data.
Naoki Miyamoto, Kouhei Yokokawa, Seishin Takao, Taeko Matsuura, Sodai Tanaka, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki
Journal of applied clinical medical physics, 21, 4, 13, 21, 18 Feb. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, Spot-scanning particle therapy possesses advantages, such as high conformity to the target and efficient energy utilization compared with those of the passive scattering irradiation technique. However, this irradiation technique is sensitive to target motion. In the current clinical situation, some motion management techniques, such as respiratory-gated irradiation, which uses an external or internal surrogate, have been clinically applied. In surrogate-based gating, the size of the gating window is fixed during the treatment in the current treatment system. In this study, we propose a dynamic gating window technique, which optimizes the size of gating window for each spot by considering a possible dosimetric error. The effectiveness of the dynamic gating window technique was evaluated by simulating irradiation using a moving target in a water phantom. In dosimetric characteristics comparison, the dynamic gating window technique exhibited better performance in all evaluation volumes with different effective depths compared with that of the fixed gate approach. The variation of dosimetric characteristics according to the target depth was small in dynamic gate compared to fixed gate. These results suggest that the dynamic gating window technique can maintain an acceptable dose distribution regardless of the target depth. The overall gating efficiency of the dynamic gate was approximately equal or greater than that of the fixed gating window. In dynamic gate, as the target depth becomes shallower, the gating efficiency will be reduced, although dosimetric characteristics will be maintained regardless of the target depth. The results of this study suggest that the proposed gating technique may potentially improve the dose distribution. However, additional evaluations should be undertaken in the future to determine clinical applicability by assuming the specifications of the treatment system and clinical situation.

The updated outcomes of bladder-preserving trimodal therapy using a real-time tumor-tracking radiotherapy system for patients with muscle-invasive bladder cancer.
Haruka Miyata, Takahiro Osawa, Takashige Abe, Hiroshi Kikuchi, Ryuji Matsumoto, Satoru Maruyama, Kentaro Nishioka, Shinichi Shimizu, Takayuki Hashimoto, Hiroki Shirato, Nobuo Shinohara
Japanese journal of clinical oncology, 19 Jan. 2020, [Peer-reviewed], [International Magazine]
English, OBJECTIVE: Bladder-preserving trimodal therapy is recognized as a promising alternative treatment for muscle-invasive bladder cancer. We report the updated outcomes of muscle-invasive bladder cancer patients that were treated using our treatment protocol, which involves radiotherapy delivered with a real-time tumor-tracking radiotherapy system. METHODS: Thirty-eight patients who were diagnosed with T2-T4N0M0 bladder cancer between 1998 and 2016 and had clinically inoperable disease or refused to undergo surgery were enrolled. The treatment protocol included maximal transurethral resection followed by whole-bladder radiotherapy (40 Gy). Concurrent nedaplatin-based chemotherapy was administered to patients with adequate renal function. At the time of the first evaluation (via transurethral resection of the tumor bed), fiducial markers were endoscopically inserted into the bladder wall around the tumor. A boost of 25 Gy was administered using the real-time tumor-tracking radiotherapy system. The second evaluation (via transurethral resection of the tumor bed) was performed 6 months after the start of treatment. The Kaplan-Meier method and Cox hazards analysis were used to analyze overall survival and cancer-specific survival. RESULTS: The median duration of the follow-up period was 28 months (range: 3-161 months). The 5- and 10-year overall survival rates were 54.9 and 41.2%, respectively. Twenty-five (65.8%) and twenty (74.1%) patients had achieved complete responses to chemoradiation at the first and second evaluations, respectively. In univariate and multivariate analyses, performance status was found to be significantly associated with overall survival [P = 0.03, hazard ratio: 3.48, 95% confidence interval: 1.15-10.6] and cancer-specific survival [P = 0.02, hazard ratio: 4.57, 95% confidence interval: 1.32-16.9], and sex was shown to be significantly associated with cancer-specific survival [P = 0.03, hazard ratio: 3.07, 95% confidence interval: 1.09-8.30]. CONCLUSIONS: Our bladder-preserving trimodal therapy protocol, which involves the use of a real-time tumor-tracking radiotherapy system, produced an acceptable overall survival rate. This therapy is a reasonable alternative for patients that are medically unfit for or do not want to undergo cystectomy.

Modified fast adaptive scatter kernel superposition (mfASKS) correction and its dosimetric impact on CBCT-based proton therapy dose calculation
Yusuke Nomura, Qiong Xu, Hao Peng, Seishin Takao, Shinichi Shimizu, Lei Xing, Hiroki Shirato
MEDICAL PHYSICS, 47, 1, 190, 200, Jan. 2020
English, Scientific journal

Modified fast adaptive scatter kernel superposition (mfASKS) correction and its dosimetric impact on CBCT-based proton therapy dose calculation.
Yusuke Nomura, Qiong Xu, Hao Peng, Seishin Takao, Shinichi Shimizu, Lei Xing, Hiroki Shirato
Medical physics, 47, 1, 190, 200, Jan. 2020, [International Magazine]
English, Scientific journal, PURPOSE: While cone beam computed tomography (CBCT) is able to provide patient anatomical information, its image quality is severely degraded due to scatter contamination, which degrades the accuracy of CBCT-based dose distribution estimation in proton therapy. In this work, we combined two existing scatter kernel correction methods: the point-spread function (PSF)-based scatter kernel derivation method and the fast adaptive scatter kernel superposition (fASKS) model, and evaluated the impact of the modified fASKS (mfASKS) correction on the accuracy of proton dose distribution estimation. To evaluate feasibility of the mfASKS approach using accurate scatter distributions, both Monte Carlo simulations and experiments were performed for an on-board CBCT machine integrated with a proton therapy machine. METHODS: We developed a strategy to modify central intensity, constant intensity, and amplitude of the scatter kernels derived from PSFs for the fASKS model. A parameter required for the fASKS model was derived by optimizing uniformity in the mfASKS-corrected reconstructed images. Subsequently, the mfASKS model was used to remove scatter in CBCT imaging. We quantitatively compared the Hounsfield Unit (HU) and proton stopping power ratio (SPR) images for five different phantoms. To assess improvement of dose calculation accuracy, a series of proton treatment plans were produced using the CBCT images with and without the mfASKS correction. RESULTS: The accuracies of both HU and SPR intensity quantifications are improved as a result of the mfASKS correction. Mean absolute water-equivalent path length difference to the true value decreases from 10.3 to 0.934 mm for the Gammex phantom (simulation). At the same time, mfASKS is able to offer more accurate dose distributions, especially at the distal fall-off region where noticeable dose overestimation is observed in the uncorrected scenario. Mean absolute relative error of proton range in the pelvic phantom improves from 5.03% to 2.57% (experiment). CONCLUSIONS: mfASKS enables more accurate CBCT-based proton dose calculation. This technique has significant implications in image-guided radiotherapy and dose verifications in adaptive proton therapy.

Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma
Soichiro Nishioka, Ping-Hsiu Wu, Toshiaki Yakabe, Amato J Giaccia, Quynh-Thu Le, Hidefumi Aoyama, Shinichi Shimizu, Hiroki Shirato, Yasuhito Onodera, Jin-Min Nam
Neuro-Oncology Advances, 2, 1, Oxford University Press (OUP), 01 Jan. 2020
Scientific journal,


Radiotherapy is the standard treatment for glioblastoma (GBM). However, radioresistance of GBM cells leads to recurrence and poor patient prognosis. Recent studies suggest that secretion factors have important roles in radioresistance of tumor cells. This study aims to determine whether Rab27b, a small GTPase involved in secretory vesicle trafficking, plays a role in radioresistance of GBM.





Microarray analysis, cell viability analysis, apoptosis assay, immunostaining, and in vivo experiments were performed to assess the effect of Rab27b on radioresistance of GBM. We further investigated paracrine effects mediated by Rab27b after X-ray irradiation using coculture systems of glioma cell lines.





Rab27b was specifically upregulated in irradiated U87MG cells. Furthermore, Rab27b knockdown decreased the proliferation of GBM cells after irradiation. Knockdown of Rab27b in U87MG cells combined with radiation treatment suppressed orthotopic tumor growth in the mouse brain and prolonged the survival of recipient mice. Interestingly, the co-upregulation of Rab27b and epiregulin (EREG), a member of the epidermal growth factor (EGF) family, correlated with radioresistance in glioma cell lines. Additionally, EREG, which was secreted from U87MG cells via Rab27b-mediated mechanism, activated EGF receptor and contributed to H4 cell proliferation in a paracrine manner.





Our results show that Rab27b mediates the radioresistance of highly malignant GBM cells. Rab27b promotes the proliferation of adjacent cells through EREG-mediated paracrine signaling after irradiation. Thus, the Rab27b-EREG pathway is a novel potential target to improve the efficacy of radiotherapy in GBM.

The urethral position may shift due to urethral catheter placement in the treatment planning for prostate radiation therapy.
Yasuhiro Dekura, Kentaro Nishioka, Takayuki Hashimoto, Naoki Miyamoto, Ryusuke Suzuki, Takaaki Yoshimura, Ryuji Matsumoto, Takahiro Osawa, Takashige Abe, Yoichi M Ito, Nobuo Shinohara, Hiroki Shirato, Shinichi Shimizu
Radiation oncology (London, England), 14, 1, 226, 226, 12 Dec. 2019, [Peer-reviewed], [International Magazine]
English, PURPOSE: To determine the best method to contour the planning organ at risk volume (PRV) for the urethra, this study aimed to investigate the displacement of a Foley catheter in the urethra with a soft and thin guide-wire. METHODS: For each patient, the study used two sets of computed tomography (CT) images for radiation treatment planning (RT-CT): (1) set with a Foley urethral catheter (4.0 mm diameter) plus a guide-wire (0.46 mm diameter) in the first RT-CT and (2) set with a guide-wire alone in the second CT recorded 2 min after the first RT-CT. Using three fiducial markers in the prostate for image fusion, the displacement between the catheter and the guide-wire in the prostatic urethra was calculated. In 155 consecutive patients treated between 2011 and 2017, 5531 slices of RT-CT were evaluated. RESULTS: Assuming that ≥3.0 mm of difference between the catheter and the guide-wire position was a significant displacement, the urethra with the catheter was displaced significantly from the urethra with the guide-wire alone in > 20% of the RT-CT slices in 23.2% (36/155) of the patients. The number of patients who showed ≥3.0 mm anterior displacement with the catheter in ≥20% RT-CT slices was significantly larger at the superior segment (38/155) than at the middle (14/155) and inferior segments (18/155) of the prostatic urethra (p < 0.0167). CONCLUSIONS: The urethral position with a Foley catheter is different from the urethral position with a thin and soft guide-wire in a significant proportion of the patients. This should be taken into account for the PRV of the urethra to ensure precise radiotherapy such as in urethra-sparing radiotherapy.

Combination of FDG-PET and FMISO-PET as a treatment strategy for patients undergoing early-stage NSCLC stereotactic radiotherapy.
Shiro Watanabe, Tetsuya Inoue, Shozo Okamoto, Keiichi Magota, Ayumi Takayanagi, Jun Sakakibara-Konishi, Norio Katoh, Kenji Hirata, Osamu Manabe, Takuya Toyonaga, Yuji Kuge, Hiroki Shirato, Nagara Tamaki, Tohru Shiga
EJNMMI research, 9, 1, 104, 104, 04 Dec. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: We investigated the prognostic predictive value of the combination of fluorodeoxyglucose (FDG)- and fluoromisonidazole (FMISO)-PET in patients with non-small cell lung carcinoma (NSCLC) treated with stereotactic body radiation therapy (SBRT). PATIENTS AND METHODS: We prospectively examined patients with pathologically proven NSCLC; all underwent FDG and FMISO PET/CT scans before SBRT. PET images were acquired using a whole-body time-of-flight PET-CT scanner with respiratory gating. We classified them into recurrent and non-recurrent groups based on their clinical follow-ups and compared the groups' tumor diameters and PET parameters (i.e., maximum of the standardized uptake value (SUVmax), metabolic tumor volume, tumor-to-muscle ratio, and tumor-to-blood ratio). We performed univariate analysis to evaluate the impact of the PET variables on the patients' progression-free survival (PFS). We divided the patients by thresholds of FDG SUVmax and FMISO SUVmax obtained from receiver operating characteristic analysis for assessment of recurrence rate and PFS. RESULTS: Thirty-two NSCLC patients (19 male and 13 females; median age, 83 years) were enrolled. All received SBRT. At the study endpoint, 23 patients (71.9%) were non-recurrent and nine patients (28.1%) had recurrent disease. Significant between-group differences were observed in tumor diameter and all the PET parameters, demonstrating that those were significant predictors of the recurrence in all patients. In the 22 patients with tumors > 2 cm, tumor diameter and FDG SUVmax were not significant predictors. Thirty-two patients were divided into three patterns from the thresholds of FDG SUVmax (6.81) and FMISO SUVmax (1.89); A, low FDG and low FMISO (n = 14); B, high FDG and low FMISO (n = 8); C, high FDG and high FMISO (n = 10). No pattern A patient experienced tumor recurrence, whereas two pattern B patients (25%) and seven pattern C patients (70%) exhibited recurrence. A Kaplan-Meier analysis of all patients revealed a significant difference in PFS between patterns A and B (p = 0.013) and between patterns A and C (p < 0.001). In the tumors > 2 cm patients, significant differences in PFS were demonstrated between pattern A and C patients (p = 0.002). CONCLUSION: The combination of FDG- and FMISO-PET can identify patients with a baseline risk of recurrence and indicate whether additional therapy might be performed to improve survival.

OC-078: Development of Gated Proton Imaging System for Moving Target
S. Tanaka, N. Miyamoto, T. Nishio, T. Yoshimura, S. Takao, Y. Matsuo, S. Shimizu, H. Shirato, T. Matsuura
Radiotherapy and Oncology, 141, S32, S33, Elsevier BV, Dec. 2019
Scientific journal

Analysis of treatment process time for real-time-image gated-spot-scanning proton-beam therapy (RGPT) system.
Yoshimura T, Shimizu S, Hashimoto T, Nishioka K, Katoh N, Inoue T, Taguchi H, Yasuda K, Matsuura T, Takao S, Tamura M, Ito YM, Matsuo Y, Tamura H, Horita K, Umegaki K, Shirato H
Journal of applied clinical medical physics, 21, 2, 38, 49, Wiley, Dec. 2019, [Peer-reviewed]
Scientific journal

胸部食道扁平上皮癌に対する術前補助化学療法・根治切除術および根治的化学放射線療法についての後方視的検討
中積 宏之, 村中 徹人, 川本 泰之, 小松 嘉人, 結城 敏志, 中野 真太郎, 澤田 憲太郎, 坂本 直哉, 打浪 雄介, 田口 大志, 白土 博樹, 海老原 裕磨, 七戸 俊明, 平野 聡
北海道医学雑誌, 94, 2, 120, 121, 北海道医学会, Nov. 2019
Japanese

当科における局所進行外耳道扁平上皮癌の治療成績の検討
加納 里志, 森田 真也, 中丸 裕爾, 水町 貴諭, 対馬 那由多, 鈴木 崇祥, 中薗 彬, 福田 篤, 安田 耕一, 鬼丸 力也, 白土 博樹, 本間 明宏
頭頸部癌, 45, 3, 300, 304, (一社)日本頭頸部癌学会, Oct. 2019
Japanese

Prediction of Hypoxia in Brain Tumors Using a Multivariate Model Built from MR Imaging and ¹⁸F-Fluorodeoxyglucose Accumulation Data.
Shimizu Y, Kudo K, Kameda H, Harada T, Fujima N, Toyonaga T, Tha KK, Shirato H
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 19, 3, 227, 234, Oct. 2019, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, PURPOSE: The aim of this study was to generate a multivariate model using various MRI markers of blood flow and vascular permeability and accumulation of 18F-fluorodeoxyglucose (FDG) to predict the extent of hypoxia in an 18F-fluoromisonidazole (FMISO)-positive region. METHODS: Fifteen patients aged 27-74 years with brain tumors (glioma, n = 13; lymphoma, n = 1; germinoma, n = 1) were included. MRI scans were performed using a 3T scanner, and dynamic contrast-enhanced (DCE) perfusion and arterial spin labeling images were obtained. Ktrans and Vp maps were generated using the DCE images. FDG and FMISO positron emission tomography scans were also obtained. A model for predicting FMISO positivity was generated on a voxel-by-voxel basis by a multivariate logistic regression model using all the MRI parameters with and without FDG. Receiver-operating characteristic curve analysis was used to detect FMISO positivity with multivariate and univariate analysis of each parameter. Cross-validation was performed using the leave-one-out method. RESULTS: The area under the curve (AUC) was highest for the multivariate prediction model with FDG (0.892) followed by the multivariate model without FDG and univariate analysis with FDG and Ktrans (0.844 for all). In cross-validation, the multivariate model with FDG had the highest AUC (0.857 ± 0.08) followed by the multivariate model without FDG (0.834 ± 0.119). CONCLUSION: A multivariate prediction model created using blood flow, vascular permeability, and glycometabolism parameters can predict the extent of hypoxia in FMISO-positive areas in patients with brain tumors.

Particle therapy for prostate cancer: The past, present and future.
Ishikawa H, Tsuji H, Murayama S, Sugimoto M, Shinohara N, Maruyama S, Murakami M, Shirato H, Sakurai H
International journal of urology : official journal of the Japanese Urological Association, 26, 10, 971, 979, Oct. 2019, [Peer-reviewed]

脾臓への放射線照射が奏功した脾機能亢進症の1例　　　　　　　　　　　　　　　
岩崎 愛美, 安田 耕一, 遠藤 知之, 大東 寛幸, 清水 伸一, 鬼丸 力也, 豊嶋 崇徳, 白土 博樹
日本医学放射線学会秋季臨床大会抄録集, 55回, S518, S518, (公社)日本医学放射線学会, Sep. 2019
Japanese

The Potential Benefit of Adaptive Intensity Modulated Proton Therapy in Nasopharyngeal Carcinoma: Planning Comparison Study
H. Minatogawa, K. Yasuda, T. Matsuura, R. Onimaru, T. Yoshimura, S. Takao, Y. Matsuo, Y. Dekura, R. Suzuki, M. Tamura, N. Miyamoto, S. Shimizu, H. Shirato
International Journal of Radiation Oncology*Biology*Physics, 105, 1, E394, E394, Elsevier BV, Sep. 2019
Scientific journal

局所進行食道癌に対してspot scanning法による根治的化学陽子線療法を施行した一例　　　　　　　　　　　　　　　
宮崎 智彦, 打浪 雄介, 田口 大志, 加藤 徳雄, 清水 伸一, 白土 博樹, 中積 宏之, 中野 真太郎, 坂本 直哉, 高尾 聖心, 田村 昌也, 松浦 妙子
日本医学放射線学会秋季臨床大会抄録集, 55回, S520, S520, (公社)日本医学放射線学会, Sep. 2019
Japanese

Initial Clinical Outcomes of Real-Time-Image Gated Spot-Scanning Proton Beam Therapy for Hepatocellular Carcinomas
N. Katoh, Y. Uchinami, D. Abo, S. Takao, T. Inoue, H. Taguchi, R. Morita, T. Soyama, T. Hashimoto, R. Onimaru, A. Prayongrat, M. Tamura, T. Matsuura, S. Shimizu, H. Shirato
International Journal of Radiation Oncology*Biology*Physics, 105, 1, E222, E223, Elsevier BV, Sep. 2019
Scientific journal

Percutaneous insertion of hepatic fiducial true-spherical markers for real-time adaptive radiotherapy.
Morita R, Abo D, Sakuhara Y, Soyama T, Katoh N, Miyamoto N, Uchinami Y, Shimizu S, Shirato H, Kudo K
Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy, 29, 6, 1, 10, Sep. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Purpose: This study evaluated the success rate and complications of percutaneous implantation of hepatic fiducial true-spherical gold markers for real-time adaptive radiotherapy (RAR), which constitutes real-time image-guided radiotherapy with gating.Material and methods: We retrospectively evaluated 100 patients who underwent 116 percutaneous intrahepatic implantations of 2-mm-diameter, spherical, gold fiducial markers before RAR from 1999 to 2016, with Seldinger's method. We defined technical success as marker placement at the intended liver parenchyma, without mispositioning, and clinical success as successful tracking of the gold marker and completion of planned RAR. Complications related to marker placement were assessed.Results: The technical success rate for true-spherical gold marker implantation was 92.2% (107/116). Nine of 116 markers migrated (intra-procedurally in seven patients, delayed in two patients). Migration out of the liver (n = 4) or intrahepatic vessels (n = 5) occurred without complications; these markers were not retrieved. The clinical success rate was 100.0% (115/115). Abdominal pain occurred in 16 patients, fever and hemorrhage in seven patients each, and pneumothorax and nausea in one patient each. No major complications were encountered.Conclusions: Percutaneous transhepatic implantation of true-spherical gold markers for RAR is feasible and can be conducted with a high success rate and low complication rate.

Lambda-Carrageenan Enhances the Effects of Radiation Therapy in Cancer Treatment by Suppressing Cancer Cell Invasion and Metastasis through Racgap1 Inhibition
Ping-Hsiu Wu, Yasuhito Onodera, Frances C. Recuenco, Amato J. Giaccia, Quynh-Thu Le, Shinichi Shimizu, Hiroki Shirato, Jin-Min Nam
Cancers, 11, 8, 1192, 1192, MDPI AG, 16 Aug. 2019
Scientific journal, Radiotherapy is used extensively in cancer treatment, but radioresistance and the metastatic potential of cancer cells that survive radiation remain critical issues. There is a need for novel treatments to improve radiotherapy. Here, we evaluated the therapeutic benefit of λ-carrageenan (CGN) to enhance the efficacy of radiation treatment and investigated the underlying molecular mechanism. CGN treatment decreased viability in irradiated cancer cells and enhanced reactive oxygen species accumulation, apoptosis, and polyploid formation. Additionally, CGN suppressed radiation-induced chemoinvasion and invasive growth in 3D lrECM culture. We also screened target molecules using a gene expression microarray analysis and focused on Rac GTPase-activating protein 1 (RacGAP1). Protein expression of RacGAP1 was upregulated in several cancer cell lines after radiation, which was significantly suppressed by CGN treatment. Knockdown of RacGAP1 decreased cell viability and invasiveness after radiation. Overexpression of RacGAP1 partially rescued CGN cytotoxicity. In a mouse xenograft model, local irradiation followed by CGN treatment significantly decreased tumor growth and lung metastasis compared to either treatment alone. Taken together, these results suggest that CGN may enhance the effectiveness of radiation in cancer therapy by decreasing cancer cell viability and suppressing both radiation-induced invasive activity and distal metastasis through downregulating RacGAP1 expression.

Impact of organ motion on volumetric and dosimetric parameters in stomach lymphomas treated with intensity-modulated radiotherapy.
Uchinami Y, Suzuki R, Katoh N, Taguchi H, Yasuda K, Miyamoto N, Ito YM, Shimizu S, Shirato H
Journal of applied clinical medical physics, 20, 8, 78, 86, Aug. 2019, [Peer-reviewed]
English, Scientific journal

Quantitative evaluation of image recognition performance of fiducial markers in real-time tumor-tracking radiation therapy.　　　　　　　　　　　　　　　
Miyamoto N, Maeda K, Abo D, Morita R, Takao S, Matsuura T, Katoh N, Umegaki K, Shimizu S, Shirato H
Physica Medica, 65, 33, 36, Aug. 2019, [Peer-reviewed]
English, Scientific journal

Projection‐domain scatter correction for cone beam computed tomography using a residual convolutional neural network
Yusuke Nomura, Qiong Xu, Hiroki Shirato, Shinichi Shimizu, Lei Xing
Medical Physics, 05 Jun. 2019, [Peer-reviewed]
English, Scientific journal

The normal tissue complication probability model-based approach considering uncertainties for the selective use of radiation modality in primary liver cancer patients.
Prayongrat A, Kobashi K, Ito YM, Katoh N, Tamura M, Dekura Y, Toramatsu C, Khorprasert C, Amornwichet N, Alisanant P, Shirato H, Shimizu S
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 135, 100, 106, Jun. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: To predict the probability of radiation-induced liver toxicity (RILT) and implement the normal tissue complication probability (NTCP) model-based approach considering confidence intervals (CIs) to select patients for new treatment techniques, such as proton beam therapy, based on a certain NTCP reduction (ΔNTCP) threshold for primary liver cancer patients. METHODS AND MATERIALS: Common Toxicity Criteria for Adverse Events (CTCAE) grade ≥2 RILT was scored. The Lyman NTCP models predicting the probability of CTCAE grade ≥2 RILT as a function of the fraction-size adjusted mean liver dose (MLD), using reference fraction size = 2 Gy/fraction and α/β ratio = 2 Gy, were fitted using the maximum likelihood method. At certain combinations of MLDs, ΔNTCP with a CI was evaluated by the delta method. RESULTS: Of the 239 patients, the incidence of CTCAE grade ≥2 RILT was 55% (46% in the Child-Pugh (CP)-A vs. 81% in the CP-B/C, p < 0.001). Among 180 CP-A patients, 40% who had viral hepatitis infections experienced toxicity vs. 32% in the nonhepatitis subgroup. The MLD was 18 Gy in the toxicity group vs. 16.1 Gy in the nontoxicity group (p = 0.002). The estimated NTCP model parameters specific to the patient subgroups and the ΔNTCP with CI assuming a particular CP classification and viral hepatitis infection status were considerably different which possible changed treatment decision. CONCLUSIONS: Patients with CP-A and viral hepatitis infection or CP-B/C cirrhosis had greater susceptibility to CTCAE grade ≥2 RILT. The estimated NTCP and ΔNTCP for individual patients along with a consideration of uncertainties improve the reliability of the NTCP model-based approach.

Machine-Learning-Based Prediction of Treatment Outcomes Using MR Imaging-Derived Quantitative Tumor Information in Patients with Sinonasal Squamous Cell Carcinomas: A Preliminary Study.
Fujima N, Shimizu Y, Yoshida D, Kano S, Mizumachi T, Homma A, Yasuda K, Onimaru R, Sakai O, Kudo K, Shirato H
Cancers, 11, 6, Jun. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, The purpose of this study was to determine the predictive power for treatment outcome of a machine-learning algorithm combining magnetic resonance imaging (MRI)-derived data in patients with sinonasal squamous cell carcinomas (SCCs). Thirty-six primary lesions in 36 patients were evaluated. Quantitative morphological parameters and intratumoral characteristics from T2-weighted images, tumor perfusion parameters from arterial spin labeling (ASL) and tumor diffusion parameters of five diffusion models from multi-b-value diffusion-weighted imaging (DWI) were obtained. Machine learning by a non-linear support vector machine (SVM) was used to construct the best diagnostic algorithm for the prediction of local control and failure. The diagnostic accuracy was evaluated using a 9-fold cross-validation scheme, dividing patients into training and validation sets. Classification criteria for the division of local control and failure in nine training sets could be constructed with a mean sensitivity of 0.98, specificity of 0.91, positive predictive value (PPV) of 0.94, negative predictive value (NPV) of 0.97, and accuracy of 0.96. The nine validation data sets showed a mean sensitivity of 1.0, specificity of 0.82, PPV of 0.86, NPV of 1.0, and accuracy of 0.92. In conclusion, a machine-learning algorithm using various MR imaging-derived data can be helpful for the prediction of treatment outcomes in patients with sinonasal SCCs.

強度変調X線治療および強度変調陽子線治療における皮膚炎と皮膚線量に関する検討　　　　　　　　　　　　　　　
安田 耕一, 湊川 英樹, 出倉 康裕, 対馬 那由多, 鈴木 崇祥, 加納 里志, 水町 貴諭, 鬼丸 力也, 清水 伸一, 本間 明宏, 白土 博樹
頭頸部癌, 45, 2, 134, 134, (一社)日本頭頸部癌学会, May 2019
Japanese

外耳道癌における強度変調陽子線治療と強度変調X線治療との線量分布の比較　　　　　　　　　　　　　　　
出倉 康裕, 安田 耕一, 湊川 英樹, 対馬 那由多, 鈴木 崇祥, 加納 里志, 水町 貴諭, 鬼丸 力也, 清水 伸一, 本間 明宏, 白土 博樹
頭頸部癌, 45, 2, 138, 138, (一社)日本頭頸部癌学会, May 2019
Japanese

Clinical experience of craniospinal intensity-modulated spot-scanning proton therapy using large fields for central nervous system medulloblastomas and germ cell tumors in children, adolescents, and young adults.
Hashimoto T, Shimizu S, Takao S, Terasaka S, Iguchi A, Kobayashi H, Mori T, Yoshimura T, Matsuo Y, Tamura M, Matsuura T, Ito YM, Onimaru R, Shirato H
Journal of radiation research, 60, 4, 527, 537, May 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, The outcomes of intensity-modulated proton craniospinal irradiation (ipCSI) are unclear. We evaluated the clinical benefit of our newly developed ipCSI system that incorporates two gantry-mounted orthogonal online X-ray imagers with a robotic six-degrees-of-freedom patient table. Nine patients (7-19 years old) were treated with ipCSI. The prescribed dose for CSI ranged from 23.4 to 36.0 Gy (relative biological effectiveness) in 13-20 fractions. Four adolescent and young adult (AYA) patients (15 years or older) were treated with vertebral-body-sparing ipCSI (VBSipCSI). Myelosuppression following VBSipCSI was compared with that of eight AYA patients treated with photon CSI at the same institution previously. The mean homogeneity index (HI) in the nine patients was 0.056 (95% confidence interval: 0.044-0.068). The mean time from the start to the end of all beam delivery was 37 min 39 s ± 2 min 24 s (minimum to maximum: 22 min 49 s - 42 min 51 s). The nadir white blood cell, hemoglobin, and platelet levels during the 4 weeks following the end of the CSI were significantly higher in the VBSipCSI group than in the photon CSI group (P = 0.0071, 0.0453, 0.0024, respectively). The levels at 4 weeks after the end of CSI were significantly higher in the VBSipCSI group than in the photon CSI group (P = 0.0023, 0.0414, 0.0061). Image-guided ipCSI was deliverable in a reasonable time with sufficient HI. Using VBSipCSI, AYA patients experienced a lower incidence of serious acute hematological toxicity than AYA patients treated with photon CSI.

Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T: Comparison with 15O-labeled Water Positron Emission Tomography.
Yasuka Kikuchi, Masanao Naya, Noriko Oyama-Manabe, Osamu Manabe, Hiroyuki Sugimori, Kohsuke Kudo, Fumi Kato, Tadao Aikawa, Hiroyuki Tsutsui, Nagara Tamaki, Hiroki Shirato
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 18, 2, 134, 141, 10 Apr. 2019, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, PURPOSE: The aim of this study was to verify coronary flow velocity reserve (CFVR) on the left main trunk (LMT) in comparison with myocardial flow reserve (MFR) by 15O-labeled water positron emission tomography (PET) (MFR-PET) in both the healthy adults and the patients with coronary artery disease (CAD), and to evaluate the feasibility of CFVR to detect CAD. METHODS: Eighteen healthy adults and 13 patients with CAD were evaluated. CFVR in LMT was estimated by 3T magnetic resonance imaging (MRI) with phase contrast technique. MFR-PET in the LMT territory including anterior descending artery and circumflex artery was calculated as the ratio of myocardial blood flow (MBF)-PET at stress to MBF-PET at rest. RESULTS: There was a significant positive relationship between CFVR and MFR-PET (R = 0.45, P < 0.0001). Inter-observer calculations of CFVR showed good correlation (R2 = 0.93, P < 0.0001). The CFVR in patients with CAD was significantly lower than that in healthy adults (1.90 ± 0.61 vs. 2.77 ± 1.03, respectively, P = 0.01), which were similar to the results of MFR-PET (2.23 ± 0.84 vs. 3.96 ± 1.04, respectively, P < 0.0001). For the detection of patients with CAD, the area under the curve was 0.78 (P = 0.01). The sensitivity was 0.77 and specificity was 0.72 when a cut-off of 2.15 was used. CONCLUSION: CFVR by 3T was validated with MFR-PET. CFVR could detect the patients with CAD. This method is a simple and reliable index without radiation or contrast material.

頭頸部癌化学放射線療法におけるEPA高配合栄養機能食品(プロシュア)の有用性の検討
水町 貴諭, 加納 里志, 本間 明宏, 赤澤 美樹子, 長谷川 千春, 城石 陽子, 岡本 千秋, 熊谷 聡美, 西村 雅勝, 高崎 裕代, 武田 宏司, 安田 耕一, 湊川 英樹, 出倉 康裕, 鬼丸 力也, 白土 博樹, 福田 諭
癌と化学療法, 46, 4, 685, 689, (株)癌と化学療法社, Apr. 2019
Japanese

[A Nutritional Supplement with a High Blend Ratio of ω-3 Fatty Acids(Prosure®) Reduces Severe Oral Mucositis and Body Weight Loss for Head and Neck Cancer Patients Treated with Chemoradiotherapy].
Mizumachi T, Kano S, Homma A, Akazawa M, Hasegawa C, Shiroishi Y, Okamoto C, Kumagai S, Nishimura M, Takasaki H, Takeda H, Yasuda K, Minatogawa H, Dekura Y, Onimaru R, Shirato H, Fukuda S
Gan to kagaku ryoho. Cancer & chemotherapy, 46, 4, 685, 689, Apr. 2019, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, BACKGROUND: Oral mucositis and body weight loss are the most critical conditions known to lead to the discontinuation of chemoradiotherapy for head and neck cancer. We investigated the effect of a nutritional supplement with a high blend ratio of w-3 fatty acids(Prosure®)on body weight loss, oral mucositis, and the completion rate of chemoradiotherapy in patients with oropharyngeal and hypopharyngeal cancer. PATIENTS AND METHODS: The study group comprised patients with oropharyngeal and hypopharyngeal cancer who were treated with concomitant cisplatin and 70 Gy of radiotherapy. These patients received 2 packs of Prosure®per day during chemoradiotherapy. RESULTS: A total of 17 patients were included in this study. The reduction in body weight was significantly improved compared with that in the historical control group that did not receive Prosure®(7.3% vs 10.3%, p<0.01), and the rate of Grade 3-4 oral mucositis was significantly reduced for the patient groups that received Prosure®(CTCAE v3.0 GradeB3; 24% vs 58%, p<0.05). The completion rate of chemoradiotherapy was not significantly different between both groups(77% vs 60%, NS). CONCLUSIONS: A nutritional supplement with a high blend ratio of w-3 fatty acids(Prosure®)had effects on oral mucositis and body weight loss in head and neck cancer patients treated with chemoradiotherapy.

Predicting metastasis in clinically negative axillary lymph nodes with minimum apparent diffusion coefficient value in luminal A-like breast cancer.
Kato F, Kudo K, Yamashita H, Baba M, Shimizu A, Oyama-Manabe N, Kinoshita R, Li R, Shirato H
Breast cancer (Tokyo, Japan), 26, 5, 628, 636, Apr. 2019, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, BACKGROUND: We investigated the usefulness of the minimum ADC value of primary breast lesions for predicting axillary lymph node (LN) status in luminal A-like breast cancers with clinically negative nodes in comparison with the mean ADC. METHODS: Forty-four luminal A-like breast cancers without axillary LN metastasis at preoperative clinical evaluation, surgically resected with sentinel LN biopsy, were retrospectively studied. Mean and minimum ADC values of each lesion were measured and statistically compared between LN positive (n = 12) and LN negative (n = 32) groups. An ROC curve was drawn to determine the best cutoff value to differentiate LN status. Correlations between mean and minimum ADC values and the number of metastatic axillary LNs were investigated. RESULTS: Mean and minimum ADC values of breast lesions with positive LN were significantly lower than those with negative LN (mean 839.9 ± 110.9 vs. 1022.2 ± 250.0 × 10- 6 mm2/s, p = 0.027, minimum 696.7 ± 128.0 vs. 925.0 ± 257.6 × 10- 6 mm2/s, p = 0.004). The sensitivity and NPV using the best cutoff value from ROC using both mean and minimum ADC were 100%. AUC of the minimum ADC (0.784) was higher than that of the mean ADC (0.719). Statistically significant negative correlations were observed between both mean and minimum ADCs and number of positive LNs, with stronger correlation to minimum ADC than mean ADC. CONCLUSIONS: The minimum ADC value of primary breast lesions predicts axillary LN metastasis in luminal A-like breast cancer with clinically negative nodes, with high sensitivity and high NPV.

A novel range-verification method using ionoacoustic wave generated from spherical gold markers for particle-beam therapy: a simulation study.
Takayanagi T, Uesaka T, Kitaoka M, Unlu MB, Umegaki K, Shirato H, Xing L, Matsuura T
Scientific reports, 9, 1, 4011, Mar. 2019, [Peer-reviewed]

The utility of MRI histogram and texture analysis for the prediction of histological diagnosis in head and neck malignancies
Fujima Noriyuki, Homma Akihiro, Harada Taisuke, Shimizu Yukie, Tha Khin Khin, Kano Satoshi, Mizumachi Takatsugu, Li Ruijiang, Kudo Kohsuke, Shirato Hiroki
CANCER IMAGING, 19, 04 Feb. 2019, [Peer-reviewed]

脳動静脈奇形SRS後に妊娠,分娩に至った1例　　　　　　　　　　　　　　　
森 崇, 鬼丸 力也, 白土 博樹, 細川 亜美, 森川 守, 水上 尚典, 中山 若樹, 西村 あや子
Japanese Journal of Radiology, 37, Suppl., 14, 14, (公社)日本医学放射線学会, Feb. 2019
Japanese

強度変調放射線治療中に皮下気腫をきたし,再検証を要した頭頸部癌患者の1例　　　　　　　　　　　　　　　
湊川 英樹, 安田 耕一, 白土 博樹, 土屋 和彦, 鈴木 隆介, 宮本 直樹, 坂下 智博, 本間 明宏, 福田 諭
Japanese Journal of Radiology, 37, Suppl., 4, 4, (公社)日本医学放射線学会, Feb. 2019
Japanese

特徴的な画像所見を呈した鞍上部immature teratomaの1例　　　　　　　　　　　　　　　
藤井 宝顕, 原田 太以佑, 清水 幸衣, 藤間 憲幸, Tha Khin Khin, 工藤 與亮, 寺坂 俊介, 長 祐子, 白土 博樹
Japanese Journal of Radiology, 37, Suppl., 4, 4, (公社)日本医学放射線学会, Feb. 2019
Japanese

くも膜下出血後にびまん性の白質障害を呈した1例　　　　　　　　　　　　　　　
古家 翔, 原田 太以佑, 清水 幸衣, 藤間 憲幸, Tha Khin Khin, 工藤 與亮, 月花 正幸, 中山 若樹, 白土 博樹
Japanese Journal of Radiology, 37, Suppl., 10, 10, (公社)日本医学放射線学会, Feb. 2019
Japanese

The utility of MRI histogram and texture analysis for the prediction of histological diagnosis in head and neck malignancies.
Fujima N, Homma A, Harada T, Shimizu Y, Tha KK, Kano S, Mizumachi T, Li R, Kudo K, Shirato H
Cancer imaging : the official publication of the International Cancer Imaging Society, 19, 1, 5, 5, Feb. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: To assess the utility of histogram and texture analysis of magnetic resonance (MR) fat-suppressed T2-weighted imaging (Fs-T2WI) for the prediction of histological diagnosis of head and neck squamous cell carcinoma (SCC) and malignant lymphoma (ML). METHODS: The cases of 57 patients with SCC (45 well/moderately and 12 poorly differentiated SCC) and 10 patients with ML were retrospectively analyzed. Quantitative parameters with histogram features (relative mean signal, coefficient of variation, kurtosis and skewness) and gray-level co-occurrence matrix (GLCM) features (contrast, correlation, energy and homogeneity) were calculated using Fs-T2WI data with a manual tumor region of interest (ROI). RESULTS: The following significantly different values were obtained for the total SCC versus ML groups: relative mean signal (3.65 ± 0.86 vs. 2.61 ± 0.49), contrast (72.9 ± 16.2 vs. 49.3 ± 8.7) and homogeneity (2.22 ± 0.25 × 10- 1 vs. 2.53 ± 0.12 × 10- 1). In the comparison of the SCC histological grades, the relative mean signal and contrast were significantly lower in the poorly differentiated SCC (2.89 ± 0.63, 56.2 ± 12.9) compared to the well/moderately SCC (3.85 ± 0.81, 77.5 ± 13.9). The homogeneity in poorly differentiated SCC (2.56 ± 0.15 × 10- 1) was higher than that of the well/moderately SCC (2.1 ± 0.18 × 10- 1). CONCLUSIONS: Parameters obtained by histogram and texture analysis of Fs-T2WI may be useful for noninvasive prediction of histological type and grade in head and neck malignancy.

Treatment outcomes of local advanced external auditory canal squamous cell carcinomas
Satoshi Kano, Shinya Morita, Yuji Nakamaru, Takatsugu Mizumachi, Nayuta Tsushima, Takayoshi Suzuki, Akira Nakazono, Atsushi Fukuda, Koichi Yasuda, Rikiya Onimaru, Hiroki Shirato, Akihiro Homma
Japanese Journal of Head and Neck Cancer, 45, 3, 300, 304, 2019, [Peer-reviewed]
Scientific journal

3D Transformation Matrix Calculation and Pixel Intensity Normalization for the Dual Focus Tracking System　　　　　　　　　　　　　　　
Kenneth Sutherland, Toshiyuki Hamada, Masayori Ishikawa, Naoki Miyamoto, Masahiro Mizuta, Hiroyuki Date, Hiroki Shirato
Journal of Medical and Biological Engineering, 2019, [Peer-reviewed]
English, Scientific journal

くも膜下出血後にびまん性の白質障害を呈した一例
古家 翔, 原田 太以佑, 清水 幸衣, 藤間 憲幸, Tha Khin Khin, 工藤 與亮, 月花 正幸, 中山 若樹, 白土 博樹
核医学, 55, 1, 40, 40, (一社)日本核医学会, Dec. 2018
Japanese

Integrating quantitative morphological and intratumoural textural characteristics in FDG-PET for the prediction of prognosis in pharynx squamous cell carcinoma patients.
N Fujima, K Hirata, T Shiga, R Li, K Yasuda, R Onimaru, K Tsuchiya, S Kano, T Mizumachi, A Homma, K Kudo, H Shirato
Clinical radiology, 73, 12, 1059.e1-1059.e8, Dec. 2018, [Peer-reviewed], [International Magazine]
English, AIM: To assess potential prognostic factors in pharynx squamous cell carcinoma (SCC) patients by quantitative morphological and intratumoural characteristics obtained by 2-[18F]-fluoro-2-deoxy-d-glucose positron-emission tomography/computed tomography (FDG-PET/CT). MATERIALS AND METHODS: The cases of 54 patients with pharynx SCC who underwent chemoradiation therapy were analysed retrospectively. Using their FDG-PET data, the quantitative morphological and intratumoural characteristics of 14 parameters were calculated. The progression-free survival (PFS) and overall survival (OS) information was obtained from patient medical records. Univariate and multivariate analyses were performed to assess the 14 quantitative parameters as well as the T-stage, N-stage, and tumour location data for their relation to PFS and OS. When an independent predictor was suggested in the multivariate analysis, the parameter was further assessed using the Kaplan-Meier method. RESULTS: In the assessment of PFS, the univariate and multivariate analyses indicated the following as independent predictors: the texture parameter of homogeneity and the morphological parameter of sphericity. In the Kaplan-Meier analysis, the PFS rate was significantly improved in the patients who had both a higher value of homogeneity (p=0.01) and a higher value of sphericity (p=0.002). With the combined use of homogeneity and sphericity, the patients with different PFS rates could be divided more clearly. CONCLUSION: The quantitative parameters of homogeneity and sphericity obtained by FDG-PET can be useful for the prediction of the PFS of pharynx SCC patients, especially when used in combination.

Intensity-Modulated Proton Therapy with Dose Painting based on Hypoxia Imaging for Nasopharyngeal Cancer
K. Yasuda, S. Takao, Y. Matsuo, T. Yoshimura, M. Tamura, H. Minatogawa, Y. Dekura, T. Matsuura, R. Onimaru, T. Shiga, S. Shimizu, K. Umegaki, H. Shirato
International Journal of Radiation Oncology*Biology*Physics, 102, 3, e378, e378, Elsevier BV, Nov. 2018
Scientific journal

Uncertainties of Normal Tissue Complication Probability (NTCP) and NTCP Difference between Radiation Treatment Modalities for Radiation-Induced Liver Toxicity in Child-Pugh A Primary Liver Cancer Patients
A. Prayongrat, K. Kobashi, Y. Ito, N. Katoh, Y. Dekura, N. Amornwichet, S. Shimizu, H. Shirato
International Journal of Radiation Oncology*Biology*Physics, 102, 3, e65, e66, Elsevier BV, Nov. 2018
Scientific journal

Analysis of Beam Delivery Times and Dose Rates for the Treatment of Mobile Tumors Using Real Time Image Gated Spot-Scanning Proton Beam Therapy
S. Shimizu, T. Yoshimura, N. Katoh, T. Inoue, T. Hashimoto, K. Nishioka, S. Takao, T. Matsuura, N. Miyamoto, Y.M. Ito, K. Umegaki, H. Shirato
International Journal of Radiation Oncology*Biology*Physics, 102, 3, S182, S183, Elsevier BV, Nov. 2018
Scientific journal

Real-Time Tumor-Tracking Radiotherapy and General Stereotactic Body Radiotherapy for Adrenal Metastasis in Patients With Oligometastasis
Katoh N, Onishi H, Uchinami Y, Inoue T, Kuriyama K, Nishioka K, Shimizu S, Komiyama T, Miyamoto N, Shirato H
TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 17, 1533033818809983, Nov. 2018, [Peer-reviewed]
English, Scientific journal

喉頭癌cT3の喉頭温存治療(CRT vs RADPLAT) 喉頭癌に対する超選択的動注と放射線同時併用療法
本間 明宏, 加納 里志, 水町 貴諭, 中薗 彬, 鈴木 崇祥, 坂下 智博, 福田 諭, 鬼丸 力也, 安田 耕一, 湊川 英樹, 出倉 康裕, 土屋 和彦, 白土 博樹
日本気管食道科学会会報, 69, 5, 319, 320, (NPO)日本気管食道科学会, Oct. 2018
Japanese

Final report of survival and late toxicities in the Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer (JCOG0702)
Onimaru R, Onishi H, Ogawa G, Hiraoka M, Ishikura S, Karasawa K, Matsuo Y, Kokubo M, Shioyama Y, Matsushita H, Ito Y, Shirato H
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 48, 12, 1076, 1082, Oct. 2018, [Peer-reviewed]
English, Scientific journal

Long-term Outcomes of Tri-modality Therapy using a real-time tumor-tracking radiotherapy system for Patients with Muscle-invasive Bladder Cancer
Miyata Haruka, Osawa Takahiro, Matsumoto Ryuji, Abe Takashige, Maruyama Satoru, Nishioka Kentaro, Shimizu Shinichi, Hashimoto Takayuki, Shirato Hiroki, Shinohara Nobuo
INTERNATIONAL JOURNAL OF UROLOGY, 25, 321, Oct. 2018, [Peer-reviewed]

Determination of the urethra position for accurate radiation therapy of prostate cancers
Dekura Yasuhiro, Nishioka Kentaro, Hashimoto Takayuki, Miyamoto Naoki, Suzuki Ryusuke, Matsumoto Ryuji, Osawa Takahiro, Abe Takashige, Maruyama Satoru, Shinohara Nobuo, Shirato Hiroki, Shimizu Shinichi
INTERNATIONAL JOURNAL OF UROLOGY, 25, 445, 445, Oct. 2018, [Peer-reviewed]
English

Semi-quantitative analysis of pre-treatment morphological and intratumoral characteristics using F-18-fluorodeoxyglucose positron-emission tomography as predictors of treatment outcome in nasal and paranasal squamous cell carcinoma
Fujima Noriyuki, Hirata Kenji, Shiga Tohru, Yasuda Koichi, Onimaru Rikiya, Tsuchiya Kazuhiko, Kano Satoshi, Mizumachi Takatsugu, Homma Akihiro, Kudo Kohsuke, Shirato Hiroki
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY, 8, 8, 788, 795, Sep. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal

Investigation of energy absorption by clustered gold nanoparticles
Jihun Kwon, Kenneth Sutherland, Anastasia Makarova, Taeko Matsuura, Takayuki Hashimoto, Hao Peng, Toshiyuki Toshito, Kikuo Umegaki, Hiroki Shirato, Shinichi Shimizu
Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 429, 34, 41, 15 Aug. 2018, [Peer-reviewed]
Scientific journal

Stereotactic body radiotherapy to treat small lung lesions clinically diagnosed as primary lung cancer by radiological examination: A prospective observational study
Tetsuya Inoue, Norio Katoh, Yoichi M Ito, Tomoki Kimura, Yasushi Nagata, Kengo Kuriyama, Hiroshi Onishi, Tadamasa Yoshitake, Yoshiyuki Shioyama, Yusuke Iizuka, Koji Inaba, Koji Konishi, Masaki Kokubo, Katsuyuki Karasawa, Takuyo Kozuka, Kensuke Tanaka, Jun Sakakibara-Konishi, Ichiro Kinoshita, Hiroki Shirato
Lung Cancer, 122, 107, 112, Elsevier Ireland Ltd, 01 Aug. 2018, [Peer-reviewed]
English, Scientific journal

An analytical dose-averaged LET calculation algorithm considering the off-axis LET enhancement by secondary protons for spot-scanning proton therapy.
Hirayama S, Matsuura T, Ueda H, Fujii Y, Fujii T, Takao S, Miyamoto N, Shimizu S, Fujimoto R, Umegaki K, Shirato H
Medical physics, 45, 7, 3404, 3416, Jul. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: To evaluate the biological effects of proton beams as part of daily clinical routine, fast and accurate calculation of dose-averaged linear energy transfer (LETd ) is required. In this study, we have developed the analytical LETd calculation method based on the pencil-beam algorithm (PBA) considering the off-axis enhancement by secondary protons. This algorithm (PBA-dLET) was then validated using Monte Carlo simulation (MCS) results. METHODS: In PBA-dLET, LET values were assigned separately for each individual dose kernel based on the PBA. For the dose kernel, we employed a triple Gaussian model which consists of the primary component (protons that undergo the multiple Coulomb scattering) and the halo component (protons that undergo inelastic, nonelastic and elastic nuclear reaction); the primary and halo components were represented by a single Gaussian and the sum of two Gaussian distributions, respectively. Although the previous analytical approaches assumed a constant LETd value for the lateral distribution of a pencil beam, the actual LETd increases away from the beam axis, because there are more scattered and therefore lower energy protons with higher stopping powers. To reflect this LETd behavior, we have assumed that the LETs of primary and halo components can take different values (LETp and LEThalo ), which vary only along the depth direction. The values of dual-LET kernels were determined such that the PBA-dLET reproduced the MCS-generated LETd distribution in both small and large fields. These values were generated at intervals of 1 mm in depth for 96 energies from 70.2 to 220 MeV and collected in the look-up table. Finally, we compared the LETd distributions and mean LETd (LETd,mean ) values of targets and organs at risk between PBA-dLET and MCS. Both homogeneous phantom and patient geometries (prostate, liver, and lung cases) were used to validate the present method. RESULTS: In the homogeneous phantom, the LETd profiles obtained by the dual-LET kernels agree well with the MCS results except for the low-dose region in the lateral penumbra, where the actual dose was below 10% of the maximum dose. In the patient geometry, the LETd profiles calculated with the developed method reproduces MCS with the similar accuracy as in the homogeneous phantom. The maximum differences in LETd,mean for each structure between the PBA-dLET and the MCS were 0.06 keV/μm in homogeneous phantoms and 0.08 keV/μm in patient geometries under all tested conditions, respectively. CONCLUSIONS: We confirmed that the dual-LET-kernel model well reproduced the MCS, not only in the homogeneous phantom but also in complex patient geometries. The accuracy of the LETd was largely improved from the single-LET-kernel model, especially at the lateral penumbra. The model is expected to be useful, especially for proper recognition of the risk of side effects when the target is next to critical organs.

Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe.
Onodera Y, Nam JM, Horikawa M, Shirato H, Sabe H
Nature communications, 9, 1, 2682, 2682, Jul. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, Mitochondria dynamically alter their subcellular localization during cell movement, although the underlying mechanisms remain largely elusive. The small GTPase Arf6 and its signaling pathway involving AMAP1 promote cell invasion via integrin recycling. Here we show that the Arf6-AMAP1 pathway promote the anterograde trafficking of mitochondria. Blocking the Arf6-based pathway causes mitochondrial aggregation near the microtubule-organizing center, and subsequently induces detrimental reactive oxygen species (ROS) production, likely via a mitochondrial ROS-induced ROS release-like mechanism. The Arf6-based pathway promotes the localization of ILK to focal adhesions to block RhoT1-TRAK2 association, which controls mitochondrial retrograde trafficking. Blockade of the RhoT1-TRAK1 machinery, rather than RhoT1-TRAK2, impairs cell invasion, but not two-dimensional random cell migration. Weakly or non-invasive cells do not notably express TRAK proteins, whereas they clearly express their mRNAs. Our results identified a novel association between cell movement and mitochondrial dynamics, which is specific to invasion and is necessary for avoiding detrimental ROS production.

Effects of Surgery With Salvage Stereotactic Radiosurgery Versus Surgery With Whole-Brain Radiation Therapy in Patients With One to Four Brain Metastases (JCOG0504): A Phase III, Noninferiority, Randomized Controlled Trial.
Takamasa Kayama, Shinya Sato, Kaori Sakurada, Junki Mizusawa, Ryo Nishikawa, Yoshitaka Narita, Minako Sumi, Yasuji Miyakita, Toshihiro Kumabe, Yukihiko Sonoda, Yoshiki Arakawa, Susumu Miyamoto, Takaaki Beppu, Kazuhiko Sugiyama, Hirohiko Nakamura, Motoo Nagane, Yoko Nakasu, Naoya Hashimoto, Mizuhiko Terasaki, Akira Matsumura, Eiichi Ishikawa, Toshihiko Wakabayashi, Yasuo Iwadate, Shiro Ohue, Hiroyuki Kobayashi, Manabu Kinoshita, Kenichiro Asano, Akitake Mukasa, Katsuyuki Tanaka, Akio Asai, Hideo Nakamura, Tatsuya Abe, Yoshihiro Muragaki, Koichi Iwasaki, Tomokazu Aoki, Takao Watanabe, Hikaru Sasaki, Shuichi Izumoto, Masahiro Mizoguchi, Takayuki Matsuo, Hideo Takeshima, Motohiro Hayashi, Hidefumi Jokura, Takashi Mizowaki, Eiji Shimizu, Hiroki Shirato, Masao Tago, Hiroshi Katayama, Haruhiko Fukuda, Soichiro Shibui
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, JCO2018786186, 20 Jun. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, Purpose Whereas whole-brain radiotherapy (WBRT) has been the standard treatment of brain metastases (BMs), stereotactic radiosurgery (SRS) is increasingly preferred to avoid cognitive dysfunction; however, it has not been clearly determined whether treatment with SRS is as effective as that with WBRT or WBRT plus SRS. We thus assessed the noninferiority of salvage SRS to WBRT in patients with BMs. Patients and Methods Patients age 20 to 79 years old with performance status scores of 0 to 2-and 3 if caused only by neurologic deficits-and with four or fewer surgically resected BMs with only one lesion > 3 cm in diameter were eligible. Patients were randomly assigned to WBRT or salvage SRS arms within 21 days of surgery. The primary end point was overall survival. A one-sided α of .05 was used. Results Between January 2006 and May 2014, 137 and 134 patients were enrolled in the WBRT and salvage SRS arms, respectively. Median overall survival was 15.6 months in both arms (hazard ratio, 1.05; 90% CI, 0.83 to 1.33; one-sided P for noninferiority = .027). Median intracranial progression-free survival of patients in the WBRT arm (10.4 months) was longer than that of patients in the salvage SRS arm (4.0 months). The proportions of patients whose Mini-Mental Status Examination and performance status scores that did not worsen at 12 months were similar in both arms; however, 16.4% of patients in the WBRT arm experienced grade 2 to 4 cognitive dysfunction after 91 days postenrollment, whereas only 7.7% of those in the SRS arm did ( P = .048). Conclusion Salvage SRS is noninferior to WBRT and can be established as a standard therapy for patients with four or fewer BMs.

Time has come for proton and carbon beam therapy
Hiroki Shirato
International Journal of Clinical Oncology, 23, 3, 421, 422, Springer Tokyo, 01 Jun. 2018, [Peer-reviewed]
English, Scientific journal

当科における局所進行外耳道扁平上皮癌の治療成績の検討　　　　　　　　　　　　　　　
加納 里志, 森田 真也, 中丸 裕爾, 水町 貴諭, 中薗 彬, 福田 篤, 安田 耕一, 鬼丸 力也, 白土 博樹, 本間 明宏
頭頸部癌, 44, 2, 181, 181, (一社)日本頭頸部癌学会, May 2018
Japanese

Preliminary results of proton radiotherapy for pediatric rhabdomyosarcoma: a multi-institutional study in Japan
Masashi Mizumoto, Shigeyuki Murayama, Tetsuo Akimoto, Yusuke Demizu, Takashi Fukushima, Yuji Ishida, Yoshiko Oshiro, Haruko Numajiri, Hiroshi Fuji, Toshiyuki Okumura, Hiroki Shirato, Hideyuki Sakurai
Cancer Medicine, 7, 5, 1870, 1874, Blackwell Publishing Ltd, 01 May 2018, [Peer-reviewed]
English, Scientific journal

当科における局所進行外耳道扁平上皮癌の治療成績の検討　　　　　　　　　　　　　　　
加納 里志, 森田 真也, 中丸 裕爾, 水町 貴諭, 中薗 彬, 福田 篤, 安田 耕一, 鬼丸 力也, 白土 博樹, 本間 明宏
頭頸部癌, 44, 2, 181, 181, (一社)日本頭頸部癌学会, May 2018
Japanese

Toll-like receptor 3 signal augments radiation-induced tumor growth retardation in a murine model
Sumito Yoshida, Hiroaki Shime, Yohei Takeda, Jin-Min Nam, Ken Takashima, Misako Matsumoto, Hiroki Shirato, Masanori Kasahara, Tsukasa Seya
Cancer Science, 109, 4, 956, 965, Blackwell Publishing Ltd, 01 Apr. 2018, [Peer-reviewed]
English, Scientific journal

Comparison of the average surviving fraction model with the integral biologically effective dose model for an optimal irradiation scheme
Ryo Takagi, Yuriko Komiya, Kenneth L Sutherland, Hiroki Shirato, Hiroyuki Date, Masahiro Mizuta
Journal of Radiation Research, 59, suppl_1, i32, i39, Oxford University Press, 01 Mar. 2018, [Peer-reviewed]
English, Scientific journal

Prospective study to evaluate the safety of the world-first spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam therapy system
Kentaro Nishioka, Anussara Prayongrat, Kota Ono, Shunsuke Onodera, Takayuki Hashimoto, Norio Katoh, Tetsuya Inoue, Rumiko Kinoshita, Koichi Yasuda, Takashi Mori, Rikiya Onimaru, Hiroki Shirato, Shinichi Shimizu
Journal of Radiation Research, 59, suppl_1, i63, i71, 01 Mar. 2018, [Peer-reviewed]
International conference proceedings

Selection of external beam radiotherapy approaches for precise and accurate cancer treatment
Hiroki Shirato, Quynh-Thu Le, Keiji Kobashi, Anussara Prayongrat, Seishin Takao, Shinichi Shimizu, Amato Giaccia, Lei Xing, Kikuo Umegaki
Journal of Radiation Research, 59, suppl_1, i2, i10, Oxford University Press, 01 Mar. 2018, [Peer-reviewed]
English, Scientific journal

Long-term outcomes of proton therapy for prostate cancer in Japan: a multi-institutional survey of the Japanese Radiation Oncology Study Group.
Hiromitsu Iwata, Hitoshi Ishikawa, Masaru Takagi, Tomoaki Okimoto, Sigeyuki Murayama, Tetsuo Akimoto, Hitoshi Wada, Takeshi Arimura, Yoshitaka Sato, Masayuki Araya, Jun-Etsu Mizoe, Masahiko Gosho, Katsumasa Nakamura, Hiroki Shirato, Hideyuki Sakurai
Cancer medicine, 7, 3, 677, 689, Mar. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, This is the first multi-institutional retrospective survey of the long-term outcomes of proton therapy (PT) for prostate cancer in Japan. This retrospective analysis comprised prostate cancer patients treated with PT at seven centers between January 2008 and December 2011 and was approved by each Institutional Review Board. The NCCN classification was used. Biochemical relapse was based on the Phoenix definition (nadir + 2.0 ng/mL). Toxicities were evaluated with the Common Terminology Criteria for Adverse Events version 4.0. There were 215, 520, and 556 patients in the low-risk, intermediate-risk, and high-risk groups, respectively. The median follow-up period of surviving patients was 69 months (range: 7-107). Among all patients, 98.8% were treated using a conventional fractionation schedule and 1.2% with a hypofractionation schedule; 58.5% and 21.5% received neoadjuvant and adjuvant androgen deprivation therapy, respectively. The 5-year biochemical relapse-free survival (bRFS) and overall survival rates in the low-risk, intermediate-risk, and high-risk groups were 97.0%, 91.1%, and 83.1%, and 98.4%, 96.8%, and 95.2%, respectively. In the multivariate analysis, the NCCN classification was a significant prognostic factor for bRFS, but not overall survival. The incidence rates of grade 2 or more severe late gastrointestinal and genitourinary toxicities were 4.1% and 4.0%, retrospectively. This retrospective analysis of a multi-institutional survey suggested that PT is effective and well-tolerated for prostate cancer. Based on this result, a multi-institutional prospective clinical trial (UMIN000025453) on PT for prostate cancer has just been initiated in order to define its role in Japan.

Present developments in reaching an international consensus for a model-based approach to particle beam therapy.
Anussara Prayongrat, Kikuo Umegaki, Arjen van der Schaaf, Albert C Koong, Steven H Lin, Thomas Whitaker, Todd McNutt, Naruhiro Matsufuji, Edward Graves, Masahiko Mizuta, Kazuhiko Ogawa, Hiroyuki Date, Kensuke Moriwaki, Yoichi M Ito, Keiji Kobashi, Yasuhiro Dekura, Shinichi Shimizu, Hiroki Shirato
Journal of radiation research, 59, suppl_1, i72-i76, i76, 01 Mar. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, Particle beam therapy (PBT), including proton and carbon ion therapy, is an emerging innovative treatment for cancer patients. Due to the high cost of and limited access to treatment, meticulous selection of patients who would benefit most from PBT, when compared with standard X-ray therapy (XRT), is necessary. Due to the cost and labor involved in randomized controlled trials, the model-based approach (MBA) is used as an alternative means of establishing scientific evidence in medicine, and it can be improved continuously. Good databases and reasonable models are crucial for the reliability of this approach. The tumor control probability and normal tissue complication probability models are good illustrations of the advantages of PBT, but pre-existing NTCP models have been derived from historical patient treatments from the XRT era. This highlights the necessity of prospectively analyzing specific treatment-related toxicities in order to develop PBT-compatible models. An international consensus has been reached at the Global Institution for Collaborative Research and Education (GI-CoRE) joint symposium, concluding that a systematically developed model is required for model accuracy and performance. Six important steps that need to be observed in these considerations include patient selection, treatment planning, beam delivery, dose verification, response assessment, and data analysis. Advanced technologies in radiotherapy and computer science can be integrated to improve the efficacy of a treatment. Model validation and appropriately defined thresholds in a cost-effectiveness centered manner, together with quality assurance in the treatment planning, have to be achieved prior to clinical implementation.

Assessing the uncertainty in a normal tissue complication probability difference ('NTCP): Radiation-induced liver disease (RILD) in liver tumour patients treated with proton vs X-ray therapy
Keiji Kobashi, Anussara Prayongrat, Takuya Kimoto, Chie Toramatsu, Yasuhiro Dekura, Norio Katoh, Shinichi Shimizu, Yoichi M Ito, Hiroki Shirato
Journal of Radiation Research, 59, suppl_1, i50, i57, Oxford University Press, 01 Mar. 2018, [Peer-reviewed]
English, Scientific journal

30年後の再発が疑われる脊髄Germinomaの1例　　　　　　　　　　　　　　　
木野田 直也, 原田 太以佑, 吉田 篤司, 清水 幸衣, 藤間 憲幸, 工藤 興亮, Khin Khin Tha, 白土 博樹, 山口 秀, 小林 浩之, 寺坂 俊介, 岡田 宏美, 畑中 佳奈子
Japanese Journal of Radiology, 36, Suppl., 3, 3, (公社)日本医学放射線学会, Feb. 2018
Japanese

長期間経過を追えたCerebral Amyloid Angiopathyの1例　　　　　　　　　　　　　　　
常田 慧徳, 原田 太以佑, 吉田 篤司, 清水 幸衣, 藤間 憲幸, 工藤 與亮, 西村 洋昭, 佐々木 秀直, Khin Khin Tha, 白土 博樹
Japanese Journal of Radiology, 36, Suppl., 13, 13, (公社)日本医学放射線学会, Feb. 2018
Japanese

亜急性連合性脊髄変性症の1例　　　　　　　　　　　　　　　
長島 諒太, 原田 太以佑, 吉田 篤司, 清水 幸衣, 藤間 憲幸, 工藤 與亮, Khin Khin Tha, 白土 博樹, 西村 洋昭, 佐々木 秀直
Japanese Journal of Radiology, 36, Suppl., 16, 16, (公社)日本医学放射線学会, Feb. 2018
Japanese

同時期に異所性に発生した悪性腫瘍に対して、二部位同時にIMRTを施行した症例　　　　　　　　　　　　　　　
湊川 英樹, 安田 耕一, 白土 博樹, 土屋 和彦, 原田 八重, 水町 貴諭, 坂下 智博, 本間 明宏, 福田 諭, 石嶋 漢, 宮本 直樹, 高尾 聖心, 鈴木 隆介, 松浦 妙子, 牧永 綾乃, 田村 昌也
Japanese Journal of Radiology, 36, Suppl., 6, 6, (公社)日本医学放射線学会, Feb. 2018
Japanese

Utility of a Hybrid IVIM-DKI Model to Predict the Development of Distant Metastasis in Head and Neck Squamous Cell Carcinoma Patients.
Noriyuki Fujima, Tomohiro Sakashita, Akihiro Homma, Daisuke Yoshida, Kohsuke Kudo, Hiroki Shirato
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 17, 1, 21, 27, 10 Jan. 2018, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, PURPOSE: To evaluate the diagnostic power of hybrid intravoxel incoherent motion (IVIM)-diffusion kurtosis imaging (DKI) model parameters in pretreatment for the prediction of future distant metastasis in head and neck squamous cell carcinoma (HNSCC) patients. MATERIALS AND METHODS: We retrospectively evaluated 49 HNSCC patients who underwent curative chemoradiation therapy. Diffusion-weighted image (DWI) acquired by single-shot spin-echo echo-planar imaging with 12 b-values (0-2000) was performed in all patients before any treatment. We calculated the IVIM-DKI parameters and the conventional apparent diffusion coefficient (ADC) in the ROI placed on the primary lesion. The presence of future distant metastasis was determined by histological findings or clinical follow-up. RESULTS: A univariate analysis revealed significant differences between the patients with distant metastasis and those without in slow diffusion coefficient (D) and kurtosis value (K). Highest diagnostic accuracy was obtained by the D value. In addition, a multivariate analysis revealed that the D value was an independent predictor of future distant metastasis. CONCLUSION: The D and K values obtained by this hybrid IVIM-DKI model can be one of the diagnostic tools for the prediction of future distant metastasis in HNSCC patients.

【悪性脊椎脊髄腫瘍に対する治療】 原発性悪性脊椎脊髄腫瘍に対する放射線治療
鬼丸 力也, 森 崇, 加藤 徳雄, 関 俊隆, 白土 博樹
脊椎脊髄ジャーナル, 30, 7, 673, 676, (株)三輪書店, Jul. 2017
Japanese

北海道大学病院の小児がん陽子線治療に対する取り組み
橋本孝之, 井口晶裕, 寺坂俊介, 杉山美奈子, 大島淳二郎, 山口秀, 小林浩之, 長祐子, 清水伸一, 鬼丸力也, 白土博樹
日本小児科学会雑誌, 121, 5, 914‐915, 915, (公社)日本小児科学会, 01 May 2017
Japanese

骨軟部腫瘍に対する陽子線治療
橋本孝之, 清水伸一, 白土博樹
北海道整形災害外科学会雑誌, 58, 2, 187‐192, 24 Mar. 2017
Japanese

Prediction of the treatment outcome using intravoxel incoherent motion and diffusional kurtosis imaging in nasal or sinonasal squamous cell carcinoma patients
Noriyuki Fujima, Daisuke Yoshida, Tomohiro Sakashita, Akihiro Homma, Akiko Tsukahara, Yukie Shimizu, Khin Khin Tha, Kohsuke Kudo, Hiroki Shirato
EUROPEAN RADIOLOGY, 27, 3, 956, 965, Mar. 2017, [Peer-reviewed]
English, Scientific journal

Long-term follow-up after proton beam therapy for pediatric tumors: a Japanese national survey
Masashi Mizumoto, Shigeyuki Murayama, Tetsuo Akimoto, Yusuke Demizu, Takashi Fukushima, Yuji Ishida, Yoshiko Oshiro, Haruko Numajiri, Hiroshi Fuji, Toshiyuki Okumura, Hiroki Shirato, Hideyuki Sakurai
CANCER SCIENCE, 108, 3, 444, 447, Mar. 2017, [Peer-reviewed]
English, Scientific journal

粒子線治療装置等が地域経済へ及ぼす影響
畔木智己, 橋本孝之, 清水伸一, 土屋和彦, 鬼丸力也, 白土博樹
Japanese Journal of Radiology, 35, Supplement, 4, 4, (公社)日本医学放射線学会, 25 Feb. 2017
Japanese

乳房温存術後接線照射後にFitz‐Hugh‐Curtis症候群様の肝周囲炎を来した1例
出倉康裕, 森崇, 西川由記子, 木下留美子, 橋本孝之, 白土博樹, 西岡健太郎, 清水伸一, 細田充主, 山下啓子
Japanese Journal of Radiology, 35, Supplement, 4, 4, (公社)日本医学放射線学会, 25 Feb. 2017
Japanese

放射線腸炎の指標としての便中αディフェンシンの可能性　　　　　　　　　　　　　　　
小野寺 俊輔, 中村 公則, 綾部 時芳, 白土 博樹
Japanese Journal of Radiology, 35, Suppl., 10, 10, (公社)日本医学放射線学会, Feb. 2017
Japanese

新たな放射線治療用病変識別マーカーの開発のための基礎的検討　　　　　　　　　　　　　　　
作原 祐介, 阿保 大介, 曽山 武士, 森田 亮, 工藤 與亮, 白土 博樹, 高橋 文也
IVR: Interventional Radiology, 31, 4, 374, 374, (一社)日本インターベンショナルラジオロジー学会, Jan. 2017
Japanese

Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells
Ping-Hsiu Wu, Yasuhito Onodera, Yuki Ichikawa, Erinn B. Rankin, Amato J. Giaccia, Yuko Watanabe, Wei Qian, Takayuki Hashimoto, Hiroki Shirato, Jin-Min Nam
INTERNATIONAL JOURNAL OF NANOMEDICINE, 12, 5069, 5085, 2017, [Peer-reviewed]
English, Scientific journal

前立腺癌の放射線治療時における尿量の変動の解析
後藤謙斗, 西岡健太郎, 松崎有華, 松浦妙子, 高尾聖心, 橋本孝之, 木下留美子, 西川由記子, 清水伸一, 白土博樹
日本放射線腫瘍学会高精度放射線外部照射部会学術大会プログラム・抄録集, 30th, 55, 2017
Japanese

高次医療連携システムによる医療情報の有効活用について 患者と医療者のためのがん治療の道標の可視化 患者中心のがん診断・治療ナビゲーションシステム開発　　　　　　　　　　　　　　　
白土 博樹, 安田 耕一, 熊木 康雄, 上杉 正人
医療情報学連合大会論文集, 36回, 1, 126, 127, (一社)日本医療情報学会, Nov. 2016
Japanese

自由行動マウスの複数組織における時計遺伝子発現のin vivo追跡定量化 (Best articles of the year)　　　　　　　　　　　　　　　
浜田俊幸, ケネスリーサザーランド, 石川正純, 宮本直樹, 本間さと, 白土博樹, 本間研一
The Hokkaido Journal of Medical Science, 91, 2, Nov. 2016, [Peer-reviewed]

Lifetime attributable risk of radiation-induced secondary cancer from proton beam therapy compared with that of intensity-modulated X-ray therapy in randomly sampled pediatric cancer patients
Tamura,Masaya, Sakurai,Hideyuki, Mizumoto,Masashi, Kamizawa,Satoshi, Murayama,Shigeyuki, Yamashita,Haruo, Takao,Seishin, Suzuki,Ryusuke, Shirato,Hiroki, Ito,M. Yoichi
J Radiat Res, 58, 3, 363, 371, OXFORD UNIV PRESS, Oct. 2016, [Peer-reviewed]
English, Scientific journal, To investigate the amount that radiation-induced secondary cancer would be reduced by using proton beam therapy (PBT) in place of intensity-modulated X-ray therapy (IMXT) in pediatric patients, we analyzed lifetime attributable risk (LAR) as an in silico surrogate marker of the secondary cancer after these treatments. From 242 pediatric patients with cancers who were treated with PBT, 26 patients were selected by random sampling after stratification into four categories: (i) brain, head and neck, (ii) thoracic, (iii) abdominal, and (iv) whole craniospinal (WCNS) irradiation. IMXT was replanned using the same computed tomography and region of interest. Using the dose-volume histograms (DVHs) of PBT and IMXT, the LARs of Schneider et al were calculated for the same patient. All the published dose-response models were tested for the organs at risk. Calculation of the LARs of PBT and IMXT based on the DVHs was feasible for all patients. The means ± standard deviations of the cumulative LAR difference between PBT and IMXT for the four categories were (i) 1.02 ± 0.52% (n = 7, P = 0.0021), (ii) 23.3 ± 17.2% (n = 8, P = 0.0065), (iii) 16.6 ± 19.9% (n = 8, P = 0.0497)

Quantitative Analysis of F-18-Fluorodeoxyglucose Positron Emission Tomography Identifies Novel Prognostic Imaging Biomarkers in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy
Yi Cui, Jie Song, Erqi Pollom, Muthuraman Alagappan, Hiroki Shirato, Daniel T. Chang, Albert C. Koong, Ruijiang Li
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 96, 1, 102, 109, Sep. 2016, [Peer-reviewed]
English, Scientific journal

中咽頭扁平上皮癌に対する化学放射線療法施行症例の臨床的検討　　　　　　　　　　　　　　　
水町 貴諭, 坂下 智博, 加納 里志, 畠山 博充, 本間 明宏, 土屋 和彦, 安田 耕一, 鬼丸 力也, 白土 博樹, 福田 諭
頭頸部癌, 42, 2, 181, 181, (一社)日本頭頸部癌学会, May 2016
Japanese

下咽頭癌に対する化学放射線療法後の嚥下障害 欧米の報告との比較　　　　　　　　　　　　　　　
本間 明宏, 畠山 博充, 水町 貴諭, 加納 里志, 坂下 智博, 鬼丸 力也, 土屋 和彦, 安田 耕一, 白土 博樹, 福田 諭
頭頸部癌, 42, 2, 214, 214, (一社)日本頭頸部癌学会, May 2016
Japanese

最前線の研究治療 強度変調陽子線治療
清水伸一, 白土博樹
医学のあゆみ, 257, 1, 19‐24, 24, 医歯薬出版, 02 Apr. 2016
Japanese

椎体IMRTとその精度に関する研究
安田耕一, 清水伸一, 橋本孝之, SUTHERLAND Ken, 白土博樹, 土屋和彦, 加藤徳雄, 鬼丸力也, 木下留美子, 井上哲也, 西岡健太郎, 西川由記子, 森崇, 原田慶一, 原田八重, 鈴木隆介, 寅松千枝, 松浦妙子, 高尾聖心, 宮本直樹, 伊藤陽一
Japanese Journal of Radiology, 34, Supplement, 5, 5, (公社)日本医学放射線学会, 25 Feb. 2016
Japanese

照射中と4DCT撮像時の肺内マーカー移動の比較
原田慶一, 加藤徳雄, 井上哲也, 鬼丸力也, 清水伸一, 白土博樹, 鈴木隆介, 宮本直樹, 石川正純
Japanese Journal of Radiology, 34, Supplement, 10, 10, (公社)日本医学放射線学会, 25 Feb. 2016
Japanese

Clinical application and future vision of the real-time tumor-tracking radiotherapy
宮本直樹, 石川正純, 井上哲也, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹
臨床放射線, 61, 2, 293‐302, 302, 金原出版(株), 10 Feb. 2016
Japanese

呼吸性移動の複雑さと対策:最新の動体追跡放射線治療
宮本直樹, 高尾聖心, 原田慶一, 石川正純, 鈴木隆介, 松浦妙子, 牧永彩乃, 井上哲也, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹
日本放射線腫瘍学会高精度放射線外部照射部会学術大会プログラム・抄録集, 29th, 46, 2016
Japanese

食道癌術後/化学放射線療法後再発に対する化学放射線療法の成績
井上哲也, 原田慶一, 加藤徳雄, 清水伸一, 白土博樹, 中積宏之, 福島拓, 小松嘉人, 海老原裕磨, 七戸俊明
北海道医学雑誌, 90, 2, 153‐154, 154, 北海道医学会, 01 Nov. 2015
Japanese

S2-1 New Parading in Particle Beam Therapy　　　　　　　　　　　　　　　
Hiroki,Shirato, Hideyuki,Sakurai, Tetsuo,Akimoto, Shigeyuki,Murayama, Tomoaki,Okimoto, Yasuhiro,Kikuchi, Kazutaka,Yamamoto
日本放射線腫瘍学会第28回学術大会報文集, 126, 126, Nov. 2015, [Peer-reviewed]
Japanese, International conference proceedings

閉塞性黄疸患者における胆道ドレナージ術前後の肝硬度の変化　　　　　　　　　　　　　　　
久保 公利, 河上 洋, 桑谷 将城, 川久保 和道, 阿部 容子, 川畑 修平, 坂本 直哉, 作原 佑介, 白土 博樹, 工藤 悠輔, 西田 睦
日本消化器病学会雑誌, 112, 臨増大会, A855, A855, (一財)日本消化器病学会, Sep. 2015
Japanese

Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer with PTV<100cc using a continual reassessment method (JCOG0702).
Onimaru R, Shirato H, Shibata T, Hiraoka M, Ishikura S, Karasawa K, Matsuo Y, Kokubo M, Shioyama Y, Matsushita H, Ito Y, Onishi H
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 116, 2, 276, 280, Elsevier {BV}, Jul. 2015, [Peer-reviewed]
PURPOSE: To estimate the maximum tolerated dose (MTD) and to determine the recommended dose (RD) of stereotactic body radiation therapy (SBRT) for peripheral T2N0M0 non-small cell carcinoma (NSCLC) with target volume (PTV) &lt; 100cc. MATERIALS AND METHODS: The continual reassessment method (CRM) was used to determine the dose level that patients should be assigned to and to estimate the MTD. Dose limiting toxicity (DLT) was grade 3 radiation pneumonitis (RP) within 180days after the start of SBRT, grade 2 RP was used as a surrogate DLT. The RD was equal to the MTD. The dose was prescribed at D95 of the PTV. RESULTS: Fifteen patients were accrued. Only 1 experienced grade 2 RP at 60Gy in 4 fractions. It was difficult to fulfill the dose constraints at 60Gy in 4 fractions, and the maximum dose level assigned by CRM was changed to 55Gy in 4 fractions. The lower limit of 95% of the credible interval exceeded the adjacent level, and the RD was determined as 55Gy in 4 fractions. CONCLUSIONS: The RD of SBRT for peripheral T2N0M0 NSCLC with PTV&lt;100cc was determined to be 55Gy in 4 fractions.

Improvement of cerebral hypometabolism after resection of radiation-induced necrotic lesion in a patient with cerebral arteriovenous malformation.
Yae Harada, Kenji Hirata, Naoki Nakayama, Shigeru Yamaguchi, Michiharu Yoshida, Shunsuke Onodera, Osamu Manabe, Tohru Shiga, Satoshi Terae, Hiroki Shirato, Nagara Tamaki
Acta radiologica open, 4, 6, 2058460115584112, 2058460115584112, Jun. 2015, [Peer-reviewed], [International Magazine]
English, A 55-year-old woman underwent radiosurgery for a left cerebral hemisphere arteriovenous malformation (AVM) and developed radiation-induced necrosis causing a massive edema in the surrounding brain tissues. Despite various therapies, the edema expanded to the ipsilateral hemisphere and induced neurological symptoms. The radiation-induced necrotic lesion was surgically removed 4 years after radiosurgery. While the preoperative FDG PET revealed severe hypometabolism in the left cerebrum, the necrotomy significantly ameliorated the brain edema, glucose metabolism (postoperative FDG PET), and symptoms. This case indicates that radiation necrosis-induced neurological deficits may be associated with brain edema and hypometabolism, which could be reversed by appropriate necrotomy.

4DCTを用いた肺内マーカー移動の解析
加藤徳雄, 原田慶一, 鈴木隆介, 井上哲也, 鬼丸力也, 清水伸一, 宮本直樹, 白土博樹
Jpn J Radiol, 33, Supplement, 5, 5, (公社)日本医学放射線学会, 25 Feb. 2015
Japanese

頭頸部における扁平上皮癌と悪性リンパ腫の腫瘍血流の違い　　　　　　　　　　　　　　　
亀田 浩之, 藤間 憲幸, 吉川 仁人, 吉田 篤司, 清水 幸衣, 吉田 大介, 塚原 亜希子, 工藤 與亮, Tha Khin Khin, 白土 博樹
Japanese Journal of Radiology, 33, Suppl., 1, 1, (公社)日本医学放射線学会, Feb. 2015
Japanese

発熱と骨病変が先行した小児白血病の1例　　　　　　　　　　　　　　　
藪崎 哲史, 宮本 憲幸, 白土 博樹, 真鍋 徳子, 藤間 憲幸, 菊池 穏香, 坂本 圭太, 三村 理恵, 加藤 芙美, 工藤 與亮, 佐藤 智信, 長 祐子, 井口 晶裕
Japanese Journal of Radiology, 33, Suppl., 2, 2, (公社)日本医学放射線学会, Feb. 2015
Japanese

孤発性筋萎縮性側索硬化症における上行性感覚路のDTI解析　　　　　　　　　　　　　　　
清水 幸衣, 藤間 憲幸, 塚原 亜希子, 工藤 與亮, 矢部 一郎, 廣谷 真, 佐々木 秀直, Tha KhinKhin, 白土 博樹
Japanese Journal of Radiology, 33, Suppl., 9, 9, (公社)日本医学放射線学会, Feb. 2015
Japanese

肝内門脈-静脈シャントによる高アンモニア血症に対して塞栓術が著効した1例　　　　　　　　　　　　　　　
高橋 文也, 作原 祐介, 薮崎 哲史, 阿保 大介, 曽山 武士, 工藤 與亮, 白土 博樹, 米澤 和彦
Japanese Journal of Radiology, 33, Suppl., 6, 6, (公社)日本医学放射線学会, Feb. 2015
Japanese

骨転移をきたした小脳膠芽腫の1例　　　　　　　　　　　　　　　
湊川 英樹, 森 崇, 鬼丸 力也, 小野寺 俊輔, 白土 博樹, 東海林 菊太郎, 吉田 道春, 小林 浩之, 寳金 清博, 菅野 宏美, 田中 伸哉
Japanese Journal of Radiology, 33, Suppl., 4, 4, (公社)日本医学放射線学会, Feb. 2015
Japanese

閉塞性黄疸患者における胆道ドレナージ後の肝硬度の変化　　　　　　　　　　　　　　　
久保 公利, 河上 洋, 桑谷 将城, 川久保 和道, 阿部 容子, 川畑 修平, 坂本 直哉, 作原 佑介, 白土 博樹, 西田 睦
超音波医学, 42, 1, 89, 89, (公社)日本超音波医学会, Jan. 2015
Japanese

International standardization of four dimensional radiotherapy system:— Enhancement of effects of irradiation and assurance of safety —
HIRATA Yuichi, SHIRATO Hiroki, MIYAMOTO Naoki, SHIMIZU Morihito, YOSHIDA Mitsuhiro, HIRAMOTO Kazuo, ICHIKAWA Yoshiaki, KANEKO Shuji, SASAGAWA Tsuyoshi, HIRAOKA Masahiro
Synthesiology English edition, 7, 4, 229, 238, National Institute of Advanced Industrial Science and Technology, 2015, [Peer-reviewed]
English, In radiation therapy for cancer, there are possibilities of position changes of the affected area during irradiation due to respiration of a patient. In order to enhance effects of irradiation for the affected area and minimize damages to the surrounding normal tissues, four dimensional radiotherapy (4DRT), which can take into account time variation of the three-dimensional position of the affected area, has been recently developed, and has been achieving significant therapeutic effects. We have proposed the International Electrotechnical Commission (IEC) standards including technical requirements of the safety aspects of the systems which realize this 4DRT, taking into account the time aspect. The reason for the proposal is that international standardization will be very effective to ensure safety of 4DRT, and international standards of IEC will have compelling force if regulatory agencies refer to them. The purpose of this paper is to summarize the analysis of the strategy in a precedent endeavor toward international standardization of the 4DRT systems, for which demands are increasing. The main point of the strategy is forming an international consensus by bringing together the opinions of specialists from various fields from a clinical point of view, focusing on the international standardization of the technical requirements of the safety aspects of the 4DRT. Based on such a strategy, we will promote developing new standards by evaluating the overall safety of the 4DRT systems for further expanding use, in addition to updating existing standards of particular equipment which constitute the 4DRT systems.

局所進行食道癌に対する強度変調放射線治療を用いた放射線化学療法の経験
井上哲也, 加藤徳雄, 清水伸一, 白土博樹, 鈴木隆介, 佐々木尚英, 福島拓, 小松嘉人
北海道外科雑誌, 59, 2, 206, 206, 北海道外科学会, 20 Dec. 2014
Japanese

肝臓への放射線治療用病変識別マーカー留置　　　　　　　　　　　　　　　
作原 祐介, 阿保 大介, 曽山 武士, 安井 太一, 寺江 聡, 加藤 徳雄, 白土 博樹
IVR: Interventional Radiology, 29, 4, 425, 425, (一社)日本インターベンショナルラジオロジー学会, Dec. 2014
Japanese

【放射線治療活用BOOK 2014】 (DIVISION-3)これからの放射線治療の展望 最新の動体追跡放射線治療装置　　　　　　　　　　　　　　　
宮本 直樹, 石川 正純, 松浦 妙子, 井上 哲也, 加藤 徳雄, 清水 伸一, 鬼丸 力也, 梅垣 菊男, 白土 博樹
Rad Fan, 12, 15, 75, 77, (株)メディカルアイ, Dec. 2014
Japanese

Intramyocellular lipid is increased in the skeletal muscle of patients with dilated cardiomyopathy with lowered exercise capacity
Hirabayashi K, Kinugawa S, Yokota T, Takada S, Fukushima A, Suga T, Takahashi M, Ono T, Morita N, Omokawa M, Harada K, Oyama-Manabe N, Shirato H, Matsushima S, Okita K, Tsutsui H
Int J Cardiol, 176, 3, 1110, 1112, Oct. 2014, [Peer-reviewed]
English, Scientific journal

内分泌療法併用動態追跡放射線治療の治療成績　　　　　　　　　　　　　　　
丸山 覚, 篠原 信雄, 安部 崇重, 土屋 邦彦, 宮島 直人, 西岡 健太郎, 清水 伸一, 白土 博樹, 野々村 克也
泌尿器外科, 27, 8, 1349, 1351, 医学図書出版(株), Aug. 2014
Japanese

北海道大学病院陽子線治療センターの小児陽子線治療開始準備状況　　　　　　　　　　　　　　　
橋本 孝之, 清水 伸一, 鬼丸 力也, 大島 淳二郎, 長 祐子, 井口 晶裕, 山口 秀, 小林 浩之, 寺坂 俊介, 岡田 忠雄, 本田 昌平, 武冨 紹信, 岡村 麗香, 中村 宏治, 白土 博樹
日本小児血液・がん学会雑誌, 51, 2, 183, 183, (NPO)日本小児血液・がん学会, Jun. 2014
Japanese

デジタル/シミュレーターハイブリッドファントムの開発とUS-CT Fusion Imagingのバリデーション　　　　　　　　　　　　　　　
曽山 武士, 作原 祐介, 阿保 大介, Wang Jeff, 伊藤 陽一, 長谷川 悠, 工藤 與亮, 白土 博樹
IVR: Interventional Radiology, 29, Suppl., 200, 200, (一社)日本インターベンショナルラジオロジー学会, May 2014
Japanese

局所進行頭頸部癌に対する導入化学療法後のweekly CDDP併用化学放射線療法の安全性と有用性の検討　　　　　　　　　　　　　　　
水町 貴諭, 本間 明宏, 坂下 智博, 加納 里志, 畠山 博充, 清水 康, 秋田 弘俊, 土屋 和彦, 安田 耕一, 鬼丸 力也, 白土 博樹, 福田 諭
頭頸部癌, 40, 2, 177, 177, (一社)日本頭頸部癌学会, May 2014
Japanese

下咽頭癌に対するRADPLATとweekly CDDP併用化学放射線治療の比較検討　　　　　　　　　　　　　　　
古沢 純, 本間 明宏, 坂下 智博, 畠山 博充, 加納 里志, 水町 貴諭, 土屋 和彦, 吉田 大介, 安田 耕一, 白土 博樹, 福田 諭
頭頸部癌, 40, 2, 198, 198, (一社)日本頭頸部癌学会, May 2014
Japanese

中咽頭扁平上皮癌症例に対するWeekly CDDP併用化学放射線療法の臨床的検討
水町 貴諭, 本間 明宏, 坂下 智博, 加納 里志, 畠山 博充, 土屋 和彦, 安田 耕一, 鬼丸 力也, 白土 博樹, 福田 諭
頭頸部癌, 40, 1, 66, 70, (一社)日本頭頸部癌学会, Apr. 2014
Japanese

Naming rule for radiation therapy
安田耕一, 土屋和彦, 井上哲也, 西岡健太郎, 原田慶一, 西川由記子, 鬼丸力也, 清水伸一, 加藤徳雄, 木下留美子, 小野寺俊介, 白土博樹, 鈴木隆介, 藤田勝久, 辻真太郎, 山崎理衣
Jpn J Radiol, 32, Supplement, 7, 7, (公社)日本医学放射線学会, 25 Feb. 2014
Japanese

北海道大学病院における髄膜腫に対する強度変調放射線治療(IMRT)の初期成績
西川由記子, 原田慶一, 西岡健太郎, 安田耕一, 井上哲也, 土屋和彦, 小野寺俊輔, 木下留美子, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹, 鈴木隆介, 石川正純
Jpn J Radiol, 32, Supplement, 5, 5, (公社)日本医学放射線学会, 25 Feb. 2014
Japanese

高精度放射線治療における呼吸性移動対策のコツとピットフォール RTRTによる呼吸性移動対策:有用性と今後の展望
宮本直樹, 石川正純, 井上哲也, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹
Rad Fan, 12, 3, 70-73,20, 73, (株)メディカルアイ, 25 Feb. 2014
Japanese

骨盤部CBCT画像での臓器輪郭描出に関する検討　　　　　　　　　　　　　　　
西岡 健太郎, 白土 博樹
Japanese Journal of Radiology, 32, Suppl., 7, 7, (公社)日本医学放射線学会, Feb. 2014
Japanese

右肝円索の4例　　　　　　　　　　　　　　　
藪崎 哲史, 阿保 大介, 安井 太一, 曽山 武士, 作原 祐介, 白土 博樹
Japanese Journal of Radiology, 32, Suppl., 2, 2, (公社)日本医学放射線学会, Feb. 2014
Japanese

腎血管筋脂肪腫に対するマイクロバルーン閉塞下エタノール塞栓術の有効性の検討　　　　　　　　　　　　　　　
児玉 芳尚, 櫻井 康雄, 作原 祐介, 阿保 大介, 曽山 武士, 寺江 聡, 白土 博樹
Japanese Journal of Radiology, 32, Suppl., 3, 3, (公社)日本医学放射線学会, Feb. 2014
Japanese

前立腺癌に対する動体追跡放射線療法における金マーカー埋め込み術　　　　　　　　　　　　　　　
土屋 邦彦, 篠原 信雄, 丸山 覚, 清水 伸一, 西岡 健太郎, 安部 崇重, 白土 博樹, 野々村 克也
泌尿器外科, 27, 2, 263, 263, 医学図書出版(株), Feb. 2014
Japanese

4次元放射線治療システムに関する国際標準化 ― 照射効果の向上と安全性の確保 ―
平田, 雄一, 宮本, 直樹, 清水, 森人, 吉田, 光宏, 平本, 和夫, 市川, 芳明, 金子, 周史, 篠川, 毅, 平岡, 真寛, 白土, 博樹
Synthesiology, 7, 4, 238, 246, National Institute of Advanced Industrial Science and Technology, 2014, [Peer-reviewed]
Japanese, Scientific journal, In radiation therapy for cancer, there are possibilities of changing of positions of the affected area during irradiation due to respiration of a patient. In order to enhance effects of irradiation for the affected area and minimize damages to the surrounding normal tissues, four dimensional radiotherapy (4DRT), which can take into account time variation of the three-dimensional position of the affected area, has been recently developed, and has been achieving significant therapeutic effect. We have proposed the International Electrotechnical Commission (IEC) standards including technical requirements of the safety aspects of the systems which realize this 4DRT, taking into account the time variation. The reason for the proposal is that international standardization will be very effective to ensure safety of 4DRT, and international standards of IEC will have compelling force if regulatory agencies refer to them. The purpose of this paper is to summarize the analysis of the strategy in a precedent endeavor toward international standardization of the 4DRT systems, for which demands are increasing. The main point of the strategy is forming an international consensus by bringing together the opinions of specialists from various fields from a clinical point of view, focusing on the international standardization of the technical requirements of the safety aspects of the 4DRT. Based on such a strategy, we will promote developing new standards by evaluating the overall safety of the 4DRT systems for further expanding use, in addition to updating existing standards of particular equipment which constitute the 4DRT systems.

Influence of respiration on dose calculation in stereotactic body radiotherapy of the lung
Yamazaki R, Onimaru R, Katoh N, Inoue T, Nishioka T, Shirato H, Date H
Radiol Phys Technol, 7, 2, 284, 289, 2014, [Peer-reviewed]

Salvage operations for patients with persistent or recurrent cancer of the maxillary sinus after superselective intra-arterial infusion of cisplatin with concurrent radiotherapy
Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Furusawa J, Yoshida D, Fujima N, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Suzuki F, Fukuda S
Br J Oral Maxillofac Surg, 52, 4, 323, 8, 2014, [Peer-reviewed]

Prospective phase II study of image-guided local boost using a real-time tumor-tracking radiotherapy (RTRT) system for locally advanced bladder cancer
Nishioka K, Shimizu S, Shinohara N, Ito Y. M, Abe T, Maruyama S, Kinoshita R, Harada K, Nishikawa N, Miyamoto N, Onimaru R, Shirato H
Jpn J Clin Oncol, 44, 1, 28, 35, 2014, [Peer-reviewed]

Design, development of water tank-type lung phantom and dosimetric verification in institutions participating in a phase I study of stereotactic body radiation therapy in patients with T2N0M0 non-small cell lung cancer: Japan Clinical Oncology Group trial
Nishio T, Shirato H, Ishikawa M, Miyabe Y, Kito S, Narita Y, Onimaru R, Ishikura S, Ito Y, Hiraoka M
J Radiat Res, 55, 3, 600, 7, 2014, [Peer-reviewed]

局所進行食道癌に対する通常照射と強度変調放射線治療を組み合わせた放射線化学療法
井上哲也, 加藤徳雄, 清水伸一, 白土博樹, 鈴木隆介, 佐々木尚英, 福島拓, 小松嘉人
北海道外科雑誌, 58, 2, 112, 216, 北海道外科学会, 20 Dec. 2013
Japanese

Detachable fibered coilを用いた肝動注reservoir留置前血流改変の経験　　　　　　　　　　　　　　　
作原 祐介, 阿保 大介, 長谷川 悠, 曽山 武士, 工藤 京平, 寺江 聡, 白土 博樹
IVR: Interventional Radiology, 28, 4, 483, 483, (一社)日本インターベンショナルラジオロジー学会, Oct. 2013
Japanese

中心静脈ポートのカテーテル先端部分に形成されたフィブリンシース・血栓をウロキナーゼで溶解した1例　　　　　　　　　　　　　　　
曽山 武士, 長谷川 悠, 工藤 京平, 阿保 大介, 作原 祐介, 寺江 聡, 白土 博樹
IVR: Interventional Radiology, 28, 4, 484, 484, (一社)日本インターベンショナルラジオロジー学会, Oct. 2013
Japanese

小児生体肝移植術後に複合的IVRを施行した1例　　　　　　　　　　　　　　　
阿保 大介, 曽山 武士, 作原 祐介, 長谷川 悠, 寺江 聡, 白土 博樹, 渡辺 正明, 山下 健一郎, 鈴木 友己, 嶋村 剛
IVR: Interventional Radiology, 28, 4, 484, 484, (一社)日本インターベンショナルラジオロジー学会, Oct. 2013
Japanese

甲状頸動脈から分岐する気管支動脈からBAEを行った1例　　　　　　　　　　　　　　　
工藤 京平, 作原 祐介, 阿保 大介, 曽山 武士, 長谷川 悠, 寺江 聡, 白土 博樹
IVR: Interventional Radiology, 28, 4, 484, 485, (一社)日本インターベンショナルラジオロジー学会, Oct. 2013
Japanese

気管腫瘍からの出血に対しTAEを施行した1例　　　　　　　　　　　　　　　
長谷川 悠, 阿保 大介, 曽山 武士, 工藤 京平, 作原 祐介, 寺江 聡, 白土 博樹
IVR: Interventional Radiology, 28, 4, 485, 485, (一社)日本インターベンショナルラジオロジー学会, Oct. 2013
Japanese

医療情報誘導治療の最新 リアルタイム4次元放射線治療の―スーパー特区の成果―
白土博樹, 鬼丸力也, 清水伸一, 石川正純, 宮本直樹, SUTHERLAND Ken, 鈴木隆介, 寅松千枝
映像情報Medical, 45, 7, 619, 623, 産業開発機構, 01 Jul. 2013
Japanese

Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging.
Khin K Tha, Satoshi Terae, Shin Nakagawa, Takeshi Inoue, Nobuki Kitagawa, Yuki Kako, Yasuya Nakato, Kawser Akter Popy, Noriyuki Fujima, Yuri Zaitsu, Daisuke Yoshida, Yoichi M Ito, Tamaki Miyamoto, Tsukasa Koyama, Hiroki Shirato
Psychiatry research, 212, 3, 208, 15, 30 Jun. 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal, Diffusion tensor imaging (DTI) is considered to be able to non-invasively quantify white matter integrity. This study aimed to use DTI to evaluate white matter integrity in non-geriatric patients with major depressive disorder (MDD) who were free of antidepressant medication. DTI was performed on 19 non-geriatric patients with MDD, free of antidepressant medication, and 19 age-matched healthy subjects. Voxel-based and histogram analyses were used to compare fractional anisotropy (FA) and mean diffusivity (MD) values between the two groups, using two-sample t tests. The abnormal DTI indices, if any, were tested for correlation with disease duration and severity, using Pearson product-moment correlation analysis. Voxel-based analysis showed clusters with FA decrease at the bilateral frontal white matter, anterior limbs of internal capsule, cerebellum, left putamen and right thalamus of the patients. Histogram analysis revealed lower peak position of FA histograms in the patients. FA values of the abnormal clusters and peak positions of FA histograms of the patients exhibited moderate correlation with disease duration and severity. These results suggest the implication of frontal-subcortical circuits and cerebellum in MDD, and the potential utility of FA in evaluation of brain parenchymal integrity.

Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging
Khin K. Tha, Satoshi Terae, Shin Nakagawa, Takeshi Inoue, Nobuki Kitagawa, Yuki Kako, Yasuya Nakato, Kawser Akter Popy, Noriyuki Fujima, Yuri Zaitsu, Daisuke Yoshida, Yoichi M. Ito, Tamaki Miyamoto, Tsukasa Koyama, Hiroki Shirato
PSYCHIATRY RESEARCH-NEUROIMAGING, 212, 3, 208, 215, Jun. 2013, [Peer-reviewed]
English, Scientific journal

Guidelines for respiratory motion management in radiation therapy
Yukinori Matsuo, Hiroshi Onishi, Keiichi Nakagawa, Mitsuhiro Nakamura, Takaki Ariji, Yu Kumazaki, Munefumi Shimbo, Naoki Tohyama, Teiji Nishio, Masahiko Okumura, Hiroki Shirato, Masahiro Hiraoka
Journal of Radiation Research, 54, 3, 561, 568, May 2013, [Peer-reviewed]
English, Scientific journal

化学放射線療法の現状と役割 動注化学療法による化学放射線療法 上顎洞癌を中心に　　　　　　　　　　　　　　　
本間 明宏, 畠山 博充, 加納 里志, 水町 貴諭, 坂下 智博, 吉田 大介, 鬼丸 力也, 土屋 和彦, 安田 耕一, 白土 博樹, 藤井 正人, 福田 諭
頭頸部癌, 39, 2, 134, 134, (一社)日本頭頸部癌学会, May 2013
Japanese

子宮体がんの画像診断 筋層浸潤・頸部浸潤の判定はどこまで可能か
三村理恵, 加藤扶美, 白土博樹
臨床婦人科産科, 67, 5, 458, 464, 医学書院, May 2013
Japanese

Regional control after concomitant chemoradiotherapy without planned neck dissection in node-positive head and neck squamous cell carcinomas
Tomohiro Sakashita, Akihiro Homma, Nobuhiko Oridate, Seigo Suzuki, Hiromitsu Hatakeyama, Satoshi Kano, Takatsugu Mizumachi, Rikiya Onimaru, Kazuhiko Tsuchiya, Koichi Yasuda, Hiroki Shirato, Satoshi Fukuda
AURIS NASUS LARYNX, 40, 2, 211, 215, Apr. 2013, [Peer-reviewed]
English, Scientific journal

Accuracy and Reliability Assessment of CT and MR Perfusion Analysis Software Using a Digital Phantom
Kohsuke Kudo, Soren Christensen, Makoto Sasaki, Leif Ostergaard, Hiroki Shirato, Kuniaki Ogasawara, Max Wintermark, Steven Warach
RADIOLOGY, 267, 1, 201, 211, Apr. 2013, [Peer-reviewed]
English, Scientific journal

肝移植術後肝動脈狭窄に対するIVR　　　　　　　　　　　　　　　
阿保 大介, 作原 祐介, 児玉 芳尚, 清水 匡, 曽山 武士, 山下 健一郎, 嶋村 剛, 寺江 聡, 白土 博樹
IVR: Interventional Radiology, 28, Suppl., 77, 77, (一社)日本インターベンショナルラジオロジー学会, Apr. 2013
Japanese

マイクロバルーンカテーテル「LOGOS」を用いた腎血管筋脂肪腫(AML)に対する選択的動脈塞栓術の初期経験　　　　　　　　　　　　　　　
阿保 大介, 作原 祐介, 曽山 武士, 寺江 聡, 白土 博樹
IVR: Interventional Radiology, 28, Suppl., 119, 119, (一社)日本インターベンショナルラジオロジー学会, Apr. 2013
Japanese

豚動脈を用いたコイル併用n-butyl-2-cianoacrylate(NBCA)塞栓術の実現性の検討　　　　　　　　　　　　　　　
阿保 大介, 作原 祐介, 曽山 武士, 寺江 聡, 白土 博樹
IVR: Interventional Radiology, 28, Suppl., 161, 161, (一社)日本インターベンショナルラジオロジー学会, Apr. 2013
Japanese

前立腺癌に対する動体追跡放射線療法における金マーカー埋め込み術
土屋邦彦, 篠原信雄, 丸山覚, 清水伸一, 西岡健太郎, 安部崇重, 白土博樹, 野々村克也
日本泌尿器科学会雑誌, 104, 2, 288, 288, (一社)日本泌尿器科学会, 20 Mar. 2013
Japanese

動体追跡装置を用いた位置照合に基づく膀胱癌放射線治療時のマージンの解析
西岡健太郎, 清水伸一, 安部崇重, 丸山覚, 鬼丸力也, 木下留美子, 小野寺俊輔, 原田慶一, 篠原信雄, 白土博樹
日本医学放射線学会総会抄録集, 72nd, S397, S397, (公社)日本医学放射線学会, 28 Feb. 2013
Japanese

Dose comparison study between RapidArc and fixed-field IMRT for postoperative whole pelvic irradiation with cervical cancer
土屋和彦, 原田慶一, 西岡健太郎, 木下留美子, 清水伸一, 白土博樹
Jpn J Radiol, 31, Supplement 1, 11, 25 Feb. 2013
Japanese

Symptomatic outcomes in relation to tumor expansion after fractionated stereotactic radiation therapy for vestibular schwannomas: Single-institutional long-term experience
Hidefumi Aoyama, Shunsuke Onodera, Norihito Takeichi, Rikiya Onimaru, Shunsuke Terasaka, Yutaka Sawamura, Hiroki Shirato
International Journal of Radiation Oncology Biology Physics, 85, 2, 329, 334, 01 Feb. 2013, [Peer-reviewed]
Scientific journal

Real-time virtual sonography(RVS)を用いた経皮的針生検　　　　　　　　　　　　　　　
藪崎 哲史, 作原 祐介, 曽山 武士, 長谷川 悠, 阿保 大介, 寺江 聡, 白土 博樹
Japanese Journal of Radiology, 31, Suppl.I, 8, 8, (公社)日本医学放射線学会, Feb. 2013
Japanese

豚動脈を用いたコイル併用n-butyl-2-cianoacrylate(NBCA)塞栓術の実現性の検討　　　　　　　　　　　　　　　
阿保 大介, 作原 祐介, 曽山 武士, 寺江 聡, 白土 博樹
日本医学放射線学会学術集会抄録集, 72回, S309, S309, (公社)日本医学放射線学会, Feb. 2013
Japanese

[F-18]fluoromisonidazole and a New PET System With Semiconductor Detectors and a Depth of Interaction System for Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer
Koichi Yasuda, Rikiya Onimaru, Shozo Okamoto, Tohru Shiga, Norio Katoh, Kazuhiko Tsuchiya, Ryusuke Suzuki, Wataru Takeuchi, Yuji Kuge, Nagara Tamaki, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 85, 1, 142, 147, Jan. 2013, [Peer-reviewed]
English, Scientific journal

beta 1-integrin via NF-kappa B signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer
Jin-Min Nam, Kazi M. Ahmed, Sylvain Costes, Hui Zhang, Yasuhito Onodera, Adam B. Olshen, Kanako C. Hatanaka, Rumiko Kinoshita, Masayori Ishikawa, Hisataka Sabe, Hiroki Shirato, Catherine C. Park
BREAST CANCER RESEARCH, 15, 4, 2013, [Peer-reviewed]
English, Scientific journal

[18F]fluoromisonidazole and a new PET system with semiconductor detectors and a depth of interaction system for intensity modulated radiation therapy for nasopharyngeal cancer
Yasuda K, Onimaru R, Okamoto S, Shiga T, Katoh N, Tsuchiya K, Suzuki R, Takeuchi W, Kuge Y, Tamaki N, Shirato H
Int J Radiat Oncol Biol Phys, 85, 1, 142, 7, 2013, [Peer-reviewed]

Superselective intra-arterial cisplatin infusion and concomitant radiotherapy for maxillary sinus cancer
Homma A, Sakashita T, Yoshida D, Onimaru R, Tsuchiya K, Suzuki F, Yasuda K, Hatakeyama H, Furusawa J, Mizumachi T, Kano S, Inamura N, Taki S, Shirato H, Fukuda S
Br J Cancer, 109, 12, 2980, 6, 2013, [Peer-reviewed]

Safety, Stability, and Location of Implantation of Multiple Gold Markers Into the Soft Bladder Wall by Rigid Cystoscopy
Nishioka K, Shimizu S, Onimaru R, Kinoshita R, Kato N, Harada K, Abe T, Maruyama S, Shinohara N, Shirato H
International Journal of Radiation Oncology Biology Physics, 87, 2, S397, 2013, [Peer-reviewed]

Can 4DCT Imaging Predict Lung Motion During Stereotactic Body Radiation Therapy?
Harada K, Katoh N, Suzuki R, Inoue T, Omimaru R, Shimizu S, Miyamoto N, Ishikawa M, Shirato H
International Journal of Radiation Oncology Biology Physics, 87, 2, S67, 2013, [Peer-reviewed]

Baseline Shift of Intrafractional Lung Tumor Motion in Real-Time Tumor-Tracking Radiation Therapy
Takao S, Miyamoto N, Matsuura T, Shimizu S, Onimaru R, Katoh N, Inoue T, Shirato H
International Journal of Radiation Oncology Biology Physics, 87, 2, S67, 2013, [Peer-reviewed]

Association of Renal Volume with the Degree of Aortic Contrast Enhancement in Abdominal CT　　　　　　　　　　　　　　　
Muto NS, Kamishima T, Sasaki T, Terae S, Tha KK, Shirato H, Bae KT
Advances in Computed Tomography, 2, 55, 62, 2013, [Peer-reviewed]
English, Scientific journal

A Mathematical Study to Select Fractionation Regimen Based on Physical Dose Distribution and the Linear-Quadratic Model
Masahiro Mizuta, Seishin Takao, Hiroyuki Date, Naoki Kishimoto, Kenneth L. Sutherland, Rikiya Onimaru, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 84, 3, 829, 833, Nov. 2012, [Peer-reviewed]
English, Scientific journal

Graphical representation of the effects on tumor and OAR for determining the appropriate fractionation regimen in radiation therapy planning
Masahiro Mizuta, Hiroyuki Date, Seishin Takao, Naoki Kishimoto, Kenneth L. Sutherland, Rikiya Onimaru, Hiroki Shirato
MEDICAL PHYSICS, 39, 11, 6791, 6795, Nov. 2012, [Peer-reviewed]
English, Scientific journal

マルチベンダに対応した放射線治療計画管理システムの開発　　　　　　　　　　　　　　　
辻 真太朗, 谷川原 綾子, 鈴木 隆介, 宮崎 智夫, 藤田 勝久, 石川 正純, 白土 博樹
医療情報学連合大会論文集, 32回, 1444, 1445, (一社)日本医療情報学会, Nov. 2012
Japanese

Combined modality therapy for laryngeal cancer with superselective intra-arterial cisplatin infusion and concomitant radiotherapy
Shigenari Taki, Akihiro Homma, Fumiyuki Suzuki, Nobuhiko Oridate, Hiromitsu Hatakeyama, Takatsugu Mizumachi, Satoshi Kano, Jun Furusawa, Tomohiro Sakashita, Naoya Inamura, Daisuke Yoshida, Rikiya Onimaru, Hiroki Shirato, Satoshi Fukuda
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 17, 5, 441, 446, Oct. 2012, [Peer-reviewed]
English, Scientific journal

Rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for squamous cell carcinoma of the nasal vestibule: a report of two cases
Homma Akihiro, Suzuki Fumiyuki, Hatakeyama Hiromitsu, Sakashita Tomohiro, Yoshida Daisuke, Tsuchiya Kazuhiko, Onimaru Rikiya, Oridate Nobuhiko, Shirato Hiroki, Fukuda Satoshi
International Cancer Conference Journal, 1, 4, 215, 219, Springer, Oct. 2012
English, Squamous cell carcinoma of the nasal vestibule (SCC-NV) is rare among head and neck malignancies. It behaves differently from cancers arising in the nasal cavity and paranasal sinuses, and skin cancer of the external nose. Prognosis is more favorable than nasal cavity tumors and less favorable than skin cancers. We experienced two cases of SCC-NV who were treated with rapid superselective high-dose cisplatin infusion with concomitant radiotherapy (RADPLAT). A 56-year-old male and a 68-year-old female with SCC-NV, classified as T4aN0M0 according to UICC and T2 according to Wang classification, were given superselective intra-arterial infusions of cisplatin, with simultaneous intravenous infusions of thiosulfate to neutralizecisplatin toxicity, together with conventionalradiotherapy. In both cases, the internal maxillary artery and the facial artery were considered to be feeders of the tumor. No serious adverse events have been observed in either patient to date during follow-up of 7.3 and 5.3 years, respectively. Both patients are alive without disease and show excellent cosmetic results. RADPLAT is considered to be useful for the treatment of patients with SCC of the nasal vestibule.

放射線治療の過去と未来 放射線治療の30年前と30年後　　　　　　　　　　　　　　　
白土 博樹, 鬼丸 力也, 清水 伸一, 土屋 和彦
日本癌治療学会誌, 47, 3, 622, 622, (一社)日本癌治療学会, Oct. 2012
Japanese

Simulation for a Real-time Positioning System for Radiotherapy Based on Annihilation Gamma-rays’ Detection from a Radiopharmaceutical Concentrated Tumor
Kaneko JH, Takada E, Hara Y, Fujita F, Yamaguchi T, Kubo N, Ishikawa M, Shirato H
PROGRESS IN NUCLEAR SCIENCE AND TECHNOLOGY, 3, 124, 126, Atomic Energy Society of Japan, Oct. 2012, [Peer-reviewed]
English

一方向X線透視による低被曝・省スペース型動体追跡装置の開発
宮本直樹, 石川正純, SUTHERLAND Kenneth, 鈴木隆介, 松浦妙子, 高尾聖心, 寅松千枝, 二本木英明, 清水伸一, 梅垣菊男, 白土博樹
医学物理 Supplement, 32, 3, 281, 282, 13 Sep. 2012
Japanese

体内複数マーカを用いた高精度ゲーティング照射法の基礎検討
大友可奈子, 宮本直樹, SUTHERLAND Kenneth, 鈴木隆介, 松浦妙子, 鬼丸力也, 清水伸一, 梅垣菊男, 白土博樹, 石川正純
医学物理 Supplement, 32, 3, 155, 156, 13 Sep. 2012
Japanese

陽子線スキャニング照射における体内マーカーによる線量遮蔽のTCPを用いた評価
前田憲一郎, 松浦妙子, 高尾聖心, SUTHERLAND Kenneth, 寅松千枝, 二本木英明, 宮本直樹, 石川正純, 清水伸一, 梅垣菊男, 白土博樹
医学物理 Supplement, 32, 3, 101, 102, 13 Sep. 2012
Japanese

陽子線治療における最適な治療ワークフローの検討
高尾聖心, 松浦妙子, 寅松千枝, 二本木英明, 宮本直樹, 清水伸一, 木下留美子, 松田浩二, 木谷貴雄, 梅垣菊男, 白土博樹
医学物理 Supplement, 32, 3, 169, 170, 13 Sep. 2012
Japanese

Biological effect of dose distortion by fiducial markers in spot-scanning proton therapy with a limited number of fields: A simulation study
Taeko Matsuura, Kenichiro Maeda, Kenneth Sutherland, Taisuke Takayanagi, Shinichi Shimizu, Seishin Takao, Naoki Miyamoto, Hideaki Nihongi, Chie Toramatsu, Yoshihiko Nagamine, Rintaro Fujimoto, Ryusuke Suzuki, Masayori Ishikawa, Kikuo Umegaki, Hiroki Shirato
MEDICAL PHYSICS, 39, 9, 5584, 5591, Sep. 2012, [Peer-reviewed]
English, Scientific journal

Feasibility of a dual microcatheter-dual interlocking detachable coil technique in preoperative embolization in preparation for distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer
Daisuke Abo, Yu Hasegawa, Yusuke Sakuhara, Satoshi Terae, Tadashi Shimizu, Khin Khin Tha, Eiichi Tanaka, Satoshi Hirano, Satoshi Kondo, Hiroki Shirato
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, 19, 4, 431, 437, Jul. 2012, [Peer-reviewed]
English, Scientific journal

Hyperintense putaminal rim at 1.5 T: prevalence in normal subjects and distinguishing features from multiple system atrophy.
Khin K Tha, Satoshi Terae, Akiko Tsukahara, Hiroyuki Soma, Ryo Morita, Ichiro Yabe, Yoichi M Ito, Hidenao Sasaki, Hiroki Shirato
BMC neurology, 12, 39, 39, 18 Jun. 2012, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Hyperintense putaminal rim (HPR) is an important magnetic resonance imaging (MRI) sign for multiple system atrophy (MSA). Recent studies have suggested that it can also be observed in normal subjects at 3 T. Whether it can be observed in normal subjects at 1.5 T is not known. This study aimed to determine whether HPR could be observed in normal subjects at 1.5 T; and if so, to establish its prevalence, the MRI characteristics, and the features which distinguish from HPR in MSA patients. METHODS: Axial T2-weighted images of 130 normal subjects were evaluated for the prevalence of HPR, its age and gender distribution, laterality, maximum dimension, association with hypointensity of nearby putamen, and presence of discontinuity. To distinguish from that observed in MSA, axial T2-weighted images of 6 MSA patients with predominant parkinsonism (MSA-P) and 15 MSA patients with predominant cerebellar symptoms (MSA-C) were also evaluated. The characteristics of HPR were compared between these patients and age-matched normal subjects. The mean diffusivity (MD) values of putamen were also compared. Fisher's exact test, t-test, and one way analysis of variance were used to determine significance at corrected p < 0.05. RESULTS: HPR was observed in 38.5% of normal subjects. Age and gender predilection and laterality were not observed. In most cases, it occupied the full length or anterior half of the lateral margin of putamen, and was continuous throughout its length. Maximum transverse dimension was 2 mm. There was no association with hypointensity of nearby putamen. However, in MSA-P, HPR was located predominantly at the posterolateral aspect of putamen, and associated with putaminal atrophy. Discontinuity of HPR was more frequently observed in MSA-P. On visual analysis, the characteristics of HPR were similar between MSA-C patients and normal subjects. Patients with MSA of either type had significantly higher MD values of putamen than normal subjects. CONCLUSIONS: HPR can be observed in 38.5% of normal subjects at 1.5 T. Thin linear hyperintensity without discontinuity, occupying the full length or anterior half of the lateral margin of the putamen, is suggestive of "normal." In doubtful cases, measurement of the MD values of nearby putamen may be valuable.

Rab5c promotes AMAP1-PRKD2 complex formation to enhance beta 1 integrin recycling in EGF-induced cancer invasion
Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Jim C. Norman, Hiroki Shirato, Shigeru Hashimoto, Hisataka Sabe
JOURNAL OF CELL BIOLOGY, 197, 7, 983, 996, Jun. 2012, [Peer-reviewed]
English, Scientific journal

Adaptive external gating based on the updating method of internal/external correlation and gating window before each beam delivery
Qing Ren, Seiko Nishioka, Hiroki Shirato, Ross Berbeco
PHYSICS IN MEDICINE AND BIOLOGY, 57, 9, N145, N157, May 2012, [Peer-reviewed]
English, Scientific journal

Preoperative percutaneous transhepatic portal vein embolization with ethanol injection.
Yusuke Sakuhara, Daisuke Abo, Yu Hasegawa, Tadashi Shimizu, Toshiya Kamiyama, Satoshi Hirano, Daisuke Fukumori, Takeshi Kawamura, Yoichi M Ito, Khin Khin Tha, Hiroki Shirato, Satoshi Terae
AJR. American journal of roentgenology, 198, 4, 914, 22, 4, Apr. 2012, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: The purpose of this article is to evaluate the feasibility and efficacy of preoperative percutaneous transhepatic portal vein embolization with ethanol injection. MATERIALS AND METHODS: We retrospectively evaluated 143 patients who underwent percutaneous transhepatic portal vein embolization. Hypertrophy of the future liver remnant was assessed by comparing the volumetric data obtained from CT image data before and after percutaneous transhepatic portal vein embolization. The evaluation of effectiveness was based on changes in the absolute volume of the future liver remnant and the ratio of the future liver remnant to the total estimated liver volume. RESULTS: Ten of 143 patients (7.0%) underwent additional embolization because of recanalization and insufficient hypertrophy of the future liver remnant. The mean increase in the ratio of the future liver remnant was 33.6% (p < 0.0001), and the mean ratio of future liver remnant to total estimated liver volume increased from 34.9% to 45.7% (p < 0.0001). Although most of the patients complained of pain after ethanol injection, they were gradually relieved of pain in a few minutes by conservative treatment. Fever (38-39°C) was reported after 47 of 151 (31.1%) percutaneous transhepatic portal vein embolization sessions and was resolved within a few days. Transient elevation of the liver transaminases was observed after the procedures and resolved within about a week. Major complications occurred in nine of 151 (6%) percutaneous transhepatic portal vein embolization sessions, but no patients developed hepatic insufficiency or severe complications precluding successful resection. One hundred twenty patients underwent hepatic resection, and two patients developed hepatic failure after surgery. CONCLUSION: Preoperative percutaneous transhepatic portal vein embolization with ethanol is a feasible and effective procedure to obtain hypertrophy of the future liver remnant for preventing hepatic failure after hepatectomy.

Prognostic Significance of Clusterin Expression in Advanced-Stage Cervical Cancer Treated With Curative Intended Radiotherapy
Hidemichi Watari, Rumiko Kinoshita, Yimin Han, Lei Wang, Masayoshi Hosaka, Hiroshi Taguchi, Kazuhiko Tsuchiya, Shinya Tanaka, Hiroki Shirato, Noriaki Sakuragi
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 22, 3, 465, 470, Mar. 2012, [Peer-reviewed]
English, Scientific journal

A New Brain Positron Emission Tomography Scanner With Semiconductor Detectors for Target Volume Delineation and Radiotherapy Treatment Planning in Patients With Nasopharyngeal Carcinoma
Norio Katoh, Koichi Yasuda, Tohru Shiga, Masakazu Hasegawa, Rikiya Onimaru, Shinichi Shimizu, Gerard Bengua, Masayori Ishikawa, Nagara Tamaki, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 82, 4, E671, E676, Mar. 2012, [Peer-reviewed]
English, Scientific journal

Real-time 4-D radiotherapy for lung cancer
Hiroki Shirato, Rikiya Onimaru, Masayori Ishikawa, Jun-ichi Kaneko, Tsuguhide Takeshima, Kenta Mochizuki, Shinichi Shimizu, Kikuo Umegaki
CANCER SCIENCE, 103, 1, 1, 6, Jan. 2012, [Peer-reviewed]
English

Usefulness of portography and contrast-enhanced computed tomography to predict the embolized area in percutaneous transhepatic portal vein embolization with absolute ethanol under temporary balloon occlusion
Yu Hasegawa, Daisuke Abo, Yusuke Sakuhara, Fumi Kato, Tamotsu Kamishimma, Tadashi Shimizu, Yoichi M. Ito, Satoshi Terae, Hiroki Shirato
JAPANESE JOURNAL OF RADIOLOGY, 30, 1, 53, 61, Jan. 2012, [Peer-reviewed]
English, Scientific journal

A Pitfall of C-11 Methionine PET Cerebral Venous Infarction Mimicked a Glioma
Yae Harada, Kenji Hirata, Hiroyuki Kobayashi, Reiko Usui, Tohru Shiga, Satoshi Terae, Hiroki Shirato, Nagara Tamaki
CLINICAL NUCLEAR MEDICINE, 37, 1, 110, 111, Jan. 2012, [Peer-reviewed]
English

Clinical outcomes of stereotactic body radiotherapy for patients with lung tumors in the state of oligo-recurrence.
Inoue T, Katoh N, Onimaru R, Shirato H
Pulmonary medicine, 2012, 369820, 2012, [Peer-reviewed]

Symptomatic Outcomes in Relation to Tumor Expansion After Fractionated Stereotactic Radiation Therapy for Vestibular Schwannomas: Single-Institutional Long-Term Experience
Aoyama H, Onodera S, Takeichi N, Onimaru R, Terasaka S, Sawamura Y, Shirato H
Int J Radiat Oncol Biol Phys, 85, 2, 329, 334, 2012, [Peer-reviewed]
English, Scientific journal

Clinical outcomes of stereotactic body radiotherapy for patients with lung tumors in the state of oligo-recurrence
Inoue T, Katoh N, Onimaru R, Shirato H
Pulm Med, 2012, 369820, 2012, [Peer-reviewed]

Improvement of tracking accuracy and stability by recursive image processing in real-time tumor-tracking radiotherapy system
Miyamoto Naoki, Sutherland Kenneth, Suzuki Ryusuke, Matsuura Taeko, Toramatsu Chie, Takao Seishin, Nihongi Hideaki, Kinoshita Rumiko, Shimizu Shinichi, Onimaru Rikiya, Umegaki Kikuo, Shirato Hiroki, Ishikawa Masayori
MEDICAL IMAGING 2012: IMAGE-GUIDED PROCEDURES, ROBOTIC INTERVENTIONS, AND MODELING, 8316, 83160, 2012, [Peer-reviewed]
International conference proceedings

The Role of Spot Scanning Proton Therapy in the Treatment of Large Abdominal Tumors: A Comparative Planning Study of Hepatocellular Carcinoma
Toramatsu C, Katoh N, Shimizu S, Nihongi H, Matsuura T, Takao S, Miyamoto N, Kinoshita R, Umegaki K, Shirato H
International Journal of Radiation Oncology Biology Physics, 84, 3, S327, S328, 2012, [Peer-reviewed]

Stereotactic Body Radiation Therapy (SBRT) Using Real-time Tracking Radiation Therapy (RTRT) System for Patients With Lung Cancer Aged 80+
Onimaru R, Katoh N, Inoue T, Shimizu S, Shinagawa N, Sakakibara-Konishi J, Oizumi S, Shirato H
International Journal of Radiation Oncology Biology Physics, 84, 3, S575, 2012, [Peer-reviewed]

Real-time Tumor-tracking Radiation Therapy for Lymphoma of the Stomach
Katoh N, Suzuki R, Shimizu S, Inoue T, Yasuda K, Onimaru R, Kimura R, Kato M, Ishikawa M, Shirato H
International Journal of Radiation Oncology Biology Physics, 84, 3, S722, 2012, [Peer-reviewed]

Interfractional Setup Error and Intrafractional Bladder Motion During Radiation Therapy for Bladder Tumors
Nishioka K, Shimizu S, Onimaru R, Kinoshita R, Harada K, Nishikawa N, Abe T, Maruyama S, Shinohara N, Shirato H
International Journal of Radiation Oncology Biology Physics, 84, 3, S769, 2012, [Peer-reviewed]

Simulation for a Real-time Positioning System for Radiotherapy Based on Annihilation　　　　　　　　　　　　　　　
Junichi H. Kaneko, Eiji Takada, Yu Hara, Fumiyuki Fujita, Toru Yamaguchi, Naoki Kubo, Masayori Ishikawa, Hiroki Shirato
Progress in Nuclear Science and Technology, 3, 104, 108, 2012, [Peer-reviewed]
English, Scientific journal, （全体概要）

腫瘍に対する放射線治療の際に呼吸等によって腫瘍が移動し、治療用放射線が正常組織に照射されることがある。それを防ぐために少数の放射線検出器で腫瘍の移動を測定し、特定の位置に腫瘍があるときのみ治療用放射線を照射するシステムについて検討し、可能性を示した。

（担当部分概要）pp.124-126

可能性検討全般に参加した。

（著者：Junichi H. Kaneko, Eiji Takada, Yu Hara, Fumiyuki Fujita, Toru Yamaguchi, Naoki Kubo, Masayori Ishikawa, Hiroki Shirato）

食道癌IMRT(強度変調放射線治療)の初期経験
原田慶一, 井上哲也, 安田耕一, 加藤徳雄, 清水伸一, 白土博樹, BENGUA Gerard, 石川正純, 中積宏之, 結城敏志, 小松嘉人
北海道外科雑誌, 56, 2, 176-177, 177, 北海道外科学会, 20 Dec. 2011
Japanese

STEREOTACTIC BODY RADIOTHERAPY (SBRT) FOR OPERABLE STAGE I NON SMALL-CELL LUNG CANCER: CAN SBRT BE COMPARABLE TO SURGERY?
Hiroshi Onishi, Hiroki Shirato, Yasushi Nagata, Masahiro Hiraoka, Masaharu Fujino, Kotaro Gomi, Katsuyuki Karasawa, Kazushige Hayakawa, Yuzuru Niibe, Yoshihiro Takai, Tomoki Kimura, Atsuya Takeda, Atsushi Ouchi, Masato Hareyama, Masaki Kokubo, Takuyo Kozuka, Takuro Arimoto, Ryusuke Hara, Jun Itami, Tsutomu Araki
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81, 5, 1352, 1358, Dec. 2011, [Peer-reviewed]
English, Scientific journal

ACCURATE ANALYSIS OF THE CHANGE IN VOLUME, LOCATION, AND SHAPE OF METASTATIC CERVICAL LYMPH NODES DURING RADIOTHERAPY
Seishin Takao, Shigeru Tadano, Hiroshi Taguchi, Koichi Yasuda, Rikiya Onimaru, Masayori Ishikawa, Gerard Bengua, Ryusuke Suzuki, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81, 3, 871, 879, Nov. 2011, [Peer-reviewed]
English, Scientific journal

Phase I study of concurrent real-time tumor-tracking thoracic radiation therapy with paclitaxel and carboplatin in locally advanced non-small cell lung cancer
Jun Sakakibara-Konishi, Satoshi Oizumi, Ichiro Kinoshita, Naofumi Shinagawa, Junko Kikuchi, Mototsugu Kato, Tetsuya Inoue, Norio Katoh, Rikiya Onimaru, Hiroki Shirato, Hirotoshi Dosaka-Akita, Masaharu Nishimura
LUNG CANCER, 74, 2, 248, 252, Nov. 2011, [Peer-reviewed]
English, Scientific journal

USE OF IMPLANTED MARKERS AND INTERPORTAL ADJUSTMENT WITH REAL-TIME TRACKING RADIOTHERAPY SYSTEM TO REDUCE INTRAFRACTION PROSTATE MOTION
Shinichi Shimizu, Yasuhiro Osaka, Nobuo Shinohara, Ataru Sazawa, Kentaro Nishioka, Ryusuke Suzuki, Rikiya Onimaru, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81, 4, E393, E399, Nov. 2011, [Peer-reviewed]
English, Scientific journal

Identification and further differentiation of subendocardial and transmural myocardial infarction by fast strain-encoded (SENC) magnetic resonance imaging at 3.0 Tesla.
Noriko Oyama-Manabe, Naoki Ishimori, Hiroyuki Sugimori, Marc Van Cauteren, Kohsuke Kudo, Osamu Manabe, Tomoyuki Okuaki, Tamotsu Kamishima, Yoichi M Ito, Hiroyuki Tsutsui, Khin Khin Tha, Satoshi Terae, Hiroki Shirato
European radiology, 21, 11, 2362, 8, 11, Nov. 2011, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: To investigate whether subendocardial and transmural myocardial infarction can be identified and differentiated using the peak circumferential and longitudinal strains measured by fast strain-encoded (SENC). METHODS: Nineteen patients with ischemic heart diseases underwent imaging with fast SENC and late gadolinium enhancement (LGE) MRI at 3 T. Fast SENC measurements were performed in three short-axis slices (basal, mid-ventricular and apical levels) and one long-axis view (four-chamber) to assess peak longitudinal and circumferential systolic strains. RESULTS: All patients showed myocardial infarction with an average of 7 positive LGE segments. A total of 304 segments for longitudinal strains (LS) and 114 segments for circumferential strains (CS) could be analysed. Positive LGE segments showed lower peak CS and LS compared with the no LGE segments (P < 0.0001 for both). Segments with subendocardial infarction showed reduced CS and LS compared with the no LGE segments (P < 0.0001 for both). There was a significant difference in CS between subendocardial and transmural infarct segments (P = 0.03), but no significant difference in LS between them (P = 0.64). CONCLUSIONS: Fast SENC can identify old myocardial infarction and differentiate subendocardial from transmural infarction.

Power Doppler signal calibration using capillary phantom for pannus vascularity in rheumatoid finger joint: a pilot study
T. Kamishima, M. Nishida, T. Horie, A. Narita, A. Sagawa, M. Henmi, H. Shirato, S. Terae
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 29, 6, 1057, 1057, Nov. 2011, [Peer-reviewed]
English

Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome
Takashi Yokota, Shintaro Kinugawa, Koichi Okita, Kagami Hirabayashi, Tadashi Suga, Masaaki Hattori, Yoshinao Nakagawa, Noriko Oyama-Manabe, Hiroki Shirato, Hiroyuki Tsutsui
HYPERTENSION RESEARCH, 34, 9, 1029, 1034, Sep. 2011, [Peer-reviewed]
English, Scientific journal

Concomitant Weekly Cisplatin and Radiotherapy for Head and Neck Cancer
Akihiro Homma, Naoya Inamura, Nobuhiko Oridate, Seigo Suzuki, Hiromitsu Hatakeyama, Takatsugu Mizumachi, Satoshi Kano, Tomohiro Sakashita, Rikiya Onimaru, Koichi Yasuda, Hiroki Shirato, Satoshi Fukuda
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 41, 8, 980, 986, Aug. 2011, [Peer-reviewed]
English, Scientific journal

Optimization of fluoroscopy parameters using pattern matching prediction in the real-time tumor-tracking radiotherapy system
Naoki Miyamoto, Masayori Ishikawa, Gerard Bengua, Kenneth Sutherland, Ryusuke Suzuki, Suguru Kimura, Shinichi Shimizu, Rikiya Onimaru, Hiroki Shirato
PHYSICS IN MEDICINE AND BIOLOGY, 56, 15, 4803, 4813, Aug. 2011, [Peer-reviewed]
English, Scientific journal

Rapid estimation of split renal function in kidney donors using software developed for computed tomographic renal volumetry
Fumi Kato, Tamotsu Kamishima, Ken Morita, Natalia S. Muto, Syozou Okamoto, Tokuhiko Omatsu, Noriko Oyama, Satoshi Terae, Kakuko Kanegae, Katsuya Nonomura, Hiroki Shirato
EUROPEAN JOURNAL OF RADIOLOGY, 79, 1, 15, 20, Jul. 2011, [Peer-reviewed]
English, Scientific journal

Efficacy of therapy for advanced hepatocellular carcinoma: Intra-arterial 5-fluorouracil and subcutaneous interferon with image-guided radiation
Makoto Chuma, Hiroshi Taguchi, Yoshiya Yamamoto, Shinichi Shimizu, Mitsuru Nakanishi, Koji Ogawa, Takuya Sho, Hiromasa Horimoto, Tomoe Kobayashi, Masato Nakai, Katsumi Terashita, Yusuke Sakuhara, Daisuke Abo, Yoko Tsukuda, Seiji Tsunematsu, Shuhei Hige, Mototsugu Kato, Hiroki Shirato, Masahiro Asaka
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 26, 7, 1123, 1132, Jul. 2011, [Peer-reviewed]
English, Scientific journal

Superselective arterial cisplatin infusion with concomitant radiation therapy for base of tongue cancer
Satoshi Kano, Akihiro Homma, Nobuhiko Oridate, Fumiyuki Suzuki, Hiromitsu Hatakeyama, Takatsugu Mizumachi, Jun Furusawa, Tomohiro Sakashita, Daisuke Yoshida, Rikiya Onimaru, Hiroki Shirato, Satoshi Fukuda
ORAL ONCOLOGY, 47, 7, 665, 670, Jul. 2011, [Peer-reviewed]
English, Scientific journal

Improved Detection of Heat Stroke-Induced Brain Injury by High B-Value Diffusion-Weighted Imaging
Kentaro Kobayashi, Khin Khin Tha, Satoshi Terae, Yuki Iijima, Kenichi Katabami, Yosuke Minami, Shinji Uegaki, Satoshi Gando, Hiroki Shirato
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 35, 4, 498, 500, Jul. 2011, [Peer-reviewed]
English, Scientific journal

Monitoring anti-interleukin 6 receptor antibody treatment for rheumatoid arthritis by quantitative magnetic resonance imaging of the hand and power Doppler ultrasonography of the finger
Tamotsu Kamishima, Kazuhide Tanimura, Masato Shimizu, Megumi Matsuhashi, Jun Fukae, Yujiro Kon, Hiromi Hagiwara, Akihiro Narita, Yuko Aoki, Naoki Kosaka, Tatsuya Atsumi, Hiroki Shirato, Satoshi Terae
SKELETAL RADIOLOGY, 40, 6, 745, 755, Jun. 2011, [Peer-reviewed]
English, Scientific journal

膵頭十二指腸切除術後膵液瘻に対する非観血的内瘻化　　　　　　　　　　　　　　　
阿保 大介, 長谷川 悠, 作原 祐介, 森田 亮, 曽山 武士, 白土 博樹, 寺江 聡, 清水 匡, 田中 栄一, 平野 聡, 近藤 哲
IVR: Interventional Radiology, 26, 2, 235, 235, (一社)日本インターベンショナルラジオロジー学会, May 2011
Japanese

Renal cortical volume measured using automatic contouring software for computed tomography and its relationship with BMI, age and renal function
Natalia Sayuri Muto, Tamotsu Kamishima, Ardene A. Harris, Fumi Kato, Yuya Onodera, Satoshi Terae, Hiroki Shirato
EUROPEAN JOURNAL OF RADIOLOGY, 78, 1, 151, 156, Apr. 2011, [Peer-reviewed]
English, Scientific journal

RELATIONSHIP BETWEEN DISEASED LUNG TISSUES ON COMPUTED TOMOGRAPHY AND MOTION OF FIDUCIAL MARKER NEAR LUNG CANCER
Yuya Onodera, Noriko Nishoka, Koichi Yasuda, Noriyuki Fujima, Mylin Torres, Tamotsu Kamishima, Noriko Ooyama, Rikiya Onimaru, Satoshi Terae, Satoshi Ooizumi, Masaharu Nishimura, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 79, 5, 1408, 1413, Apr. 2011, [Peer-reviewed]
English, Scientific journal

Long-term Outcomes of Fractionated Stereotactic Radiotherapy for Intracranial Skull Base Benign Meningiomas in Single Institution
Shunsuke Onodera, Hidefumi Aoyama, Norio Katoh, Hiroshi Taguchi, Kouichi Yasuda, Daisuke Yoshida, Ken Surtherland, Ryusuke Suzuki, Masayori Ishikawa, Bengua Gerard, Shunsuke Terasaka, Hiroki Shirato
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 41, 4, 462, 468, Apr. 2011, [Peer-reviewed]
English, Scientific journal

Dynamic gating window for compensation of baseline shift in respiratory-gated radiation therapy
Eric W. Pepin, Huanmei Wu, Hiroki Shirato
MEDICAL PHYSICS, 38, 4, 1912, 1918, Apr. 2011, [Peer-reviewed]
English, Scientific journal

Susceptibility of T-max to tracer delay on perfusion analysis: quantitative evaluation of various deconvolution algorithms using digital phantoms
Kohsuke Kudo, Makoto Sasaki, Leif Ostergaard, Soren Christensen, Ikuko Uwano, Masako Suzuki, Kuniaki Ogasawara, Hiroki Shirato, Akira Ogawa
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 31, 3, 908, 912, Mar. 2011, [Peer-reviewed]
English, Scientific journal

乳房温存術後の全乳房照射における接線照射と強度変調放射線治療との比較
土屋和彦, 木下留美子, 清水伸一, 森崇, 原田慶一, 白土博樹
日本医学放射線学会総会抄録集, 70th, S371, 28 Feb. 2011
Japanese

画像誘導局所Boostを併用した局所進行膀胱癌に対する根治的放射線治療
西岡健太郎, 清水伸一, 大坂康博, 西川昇, 喜多村圭, 白土博樹, 篠原信雄, 佐澤陽
日本医学放射線学会総会抄録集, 70th, S219-S220, 28 Feb. 2011
Japanese

Prenatal diagnosis of short-rib polydactyly syndrome type 3 (Verma-Naumoff type) by three-dimensional helical computed tomography
Takahiro Yamada, Gen Nishimura, Keiichiro Nishida, Hideaki Sawai, Tokuhiko Omatsu, Taichi Kimura, Hiroshi Nishihara, Rina Shono, Shigeki Shimada, Mamoru Morikawa, Masato Mizushima, Takashi Yamada, Kazutoshi Cho, Shinya Tanaka, Hiroki Shirato, Hisanori Minakami
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 37, 2, 151, 155, Feb. 2011, [Peer-reviewed]
English, Scientific journal

A feasibility study of a molecular-based patient setup verification method using a parallel-plane PET system
Satoshi Yamaguchi, Masayori Ishikawa, Gerard Bengua, Kenneth Sutherland, Teiji Nishio, Satoshi Tanabe, Naoki Miyamoto, Ryusuke Suzuki, Hiroki Shirato
PHYSICS IN MEDICINE AND BIOLOGY, 56, 4, 965, 977, Feb. 2011, [Peer-reviewed]
English, Scientific journal

Single-slice epicardial fat area measurement: do we need to measure the total epicardial fat volume?
Noriko Oyama, Daisuke Goto, Yoichi M Ito, Naoki Ishimori, Rie Mimura, Tomoo Furumoto, Fumi Kato, Hiroyuki Tsutsui, Nagara Tamaki, Satoshi Terae, Hiroki Shirato
Japanese journal of radiology, 29, 2, 104, 9, 2, Feb. 2011, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, PURPOSE: The aim of this study was to assess a method for measuring epicardial fat volume (EFV) by means of a single-slice area measurement. We investigated the relation between a single-slice fat area measurement and total EFV. METHODS AND METHODS: A series of 72 consecutive patients (ages 65 ± 11 years; 36 men) who had undergone cardiac computed tomography (CT) on a 64-slice multidetector scanner with prospective electrocardiographic triggering were retrospectively reviewed. Pixels in the pericardium with a density range from -230 to -30 Hounsfield units were considered fat, giving the per-slice epicardial fat area (EFA). The EFV was estimated by the summation of EFAs multiplied by the slice thickness. We investigated the relation between total EFV and each EFA. RESULTS: EFAs measured at several anatomical landmarks-right pulmonary artery, origins of the left main coronary artery, right coronary artery, coronary sinus-all correlated with the EFV (r = 0.77-0.92). The EFA at the LMCA level was highly reproducible and showed an excellent correlation with the EFV (r = 0.92). CONCLUSION: The EFA is significantly correlated with the EFV. The EFA is a simple, quick method for representing the time-consuming EFV, which has been used as a predictive indicator of cardiovascular diseases.

聴神経鞘腫の定位放射線治療 一過性腫瘍増大と症状変化の関連　　　　　　　　　　　　　　　
青山 英史, 小野寺 俊輔, 白土 博樹
日本医学放射線学会学術集会抄録集, 70回, S298, S298, (公社)日本医学放射線学会, Feb. 2011
English

Single-slice epicardial fat area measurement: do we need to measure the total epicardial fat volume?
Noriko Oyama, Daisuke Goto, Yoichi M. Ito, Naoki Ishimori, Rie Mimura, Tomoo Furumoto, Fumi Kato, Hiroyuki Tsutsui, Nagara Tamaki, Satoshi Terae, Hiroki Shirato
JAPANESE JOURNAL OF RADIOLOGY, 29, 2, 104, 109, Feb. 2011, [Peer-reviewed]
English, Scientific journal

Simplified approach to MR image quantification of the rheumatoid wrist: a pilot study
Tamotsu Kamishima, Kazuhide Tanimura, Yuko Aoki, Naoki Kosaka, Masato Shimizu, Megumi Matsuhashi, Jun Fukae, Yujiro Kon, Satoshi Terae, Hiroki Shirato
SKELETAL RADIOLOGY, 40, 1, 65, 74, Jan. 2011, [Peer-reviewed]
English, Scientific journal

Radiotherapy for Glottic T1N0 Carcinoma with Slight Hypofractionation and Standard Overall Treatment Time: Importance of Overall Treatment Time
Rikiya Onimaru, Masakazu Hasegawa, Kouichi Yasuda, Akihiro Homma, Nobuhiko Oridate, Satoshi Fukuda, Hiroki Shirato
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 41, 1, 103, 109, Jan. 2011, [Peer-reviewed]
English, Scientific journal

Radiation-induced Cancer Cell Repopulation: A Possible Mechanism Implied by Experiments Using Transplantable Mouse-derived Sarcoma Cell Line
Takeshi Nishioka, Motoaki Yasuda, Tsuguhide Takeshima, Hisashi Haga, Yusuke Miyai, Ken-ichiro Shibata, Rie Yamazaki, Hiroki Shirato, Masahiro Teduka, Hiroyuki Date
CELL STRUCTURE AND FUNCTION, 36, 1, 13, 20, 2011, [Peer-reviewed]
English, Scientific journal

Comparison of H-1 MR Spectroscopy, 3-point DIXON, and Multi-echo Gradient Echo for Measuring Hepatic Fat Fraction
Kinya Ishizaka, Noriko Oyama, Suzuko Mito, Hiroyuki Sugimori, Mitsuhiro Nakanishi, Tomoyuki Okuaki, Hiroki Shirato, Satoshi Terae
MAGNETIC RESONANCE IN MEDICAL SCIENCES, 10, 1, 41, 48, 2011, [Peer-reviewed]
English, Scientific journal

Dynamic MR Findings of Ductal Carcinoma in Situ within a Fibroadenoma
Fumi Kato, Tokuhiko Omatsu, Wakana Matsumura, Masato Takahashi, Mitsuchika Hosoda, Hiromasa Takahashi, Kanako Kubota, Noriko Oyama-Manabe, Satoshi Terae, Hiroki Shirato
MAGNETIC RESONANCE IN MEDICAL SCIENCES, 10, 2, 129, 132, 2011, [Peer-reviewed]
English, Scientific journal

Detection of patient setup errors with a portal image - DRR registration software application
Kenneth Sutherland, Masayori Ishikawa, Gerard Bengua, Yoichi M. Ito, Yoshiko Miyamoto, Hiroki Shirato
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 12, 3, 2, 15, 2011, [Peer-reviewed]
English, Scientific journal

Use of implanted markers and interportal adjustment with real-time tracking radiotherapy system to reduce intrafraction prostate motion.
Shimizu S, Osaka Y, Shinohara N, Sazawa A, Nishioka K, Suzuki R, Onimaru R, Shirato H
Int J Radiat Oncol Biol Phys, 81, 4, e393, 9, 2011, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: Interportal adjustment was applied to patients with prostate cancer using three fiducial markers and two sets of fluoroscopy in a real-time tumor-tracking radiotherapy (RTRT) system. The incidence of table position adjustment required to keep intrafractional uncertainty within 2.0 mm was investigated in this study. METHODS AND MATERIALS: The coordinates of the center of gravity of the three fiducial markers were measured at the start of every portal irradiation in intensity-modulated radiotherapy (IMRT) with seven ports. The table position was adjusted to the planned position if the discrepancy was larger than 2.0 mm in the anterior-posterior (AP), cranial-caudal (CC), or left-right (LR) directions. In total, we analyzed 4,541 observations in 20 patients who received 70 Gy in 30 fractions (7.6 times a day on average). RESULTS: The incidence of table position adjustment at 10 minutes from the initial setup of each treatment was 14.2%, 12.3%, and 5.0% of the observations in the AP, CC, and LR directions, respectively. The accumulated incidence of the table position adjustment was significantly higher at 10 minutes than at 2 minutes for AP (p = 0.0033) and CC (p = 0.0110) but not LR (p = 0.4296). An adjustment greater than 5 mm was required at least once in the treatment period in 11 (55%) patients. CONCLUSIONS: Interportal adjustment of table position was required in more than 10% of portal irradiations during the 10-minute period after initial setup to maintain treatment accuracy within 2.0 mm.

Relationship between diseased lung tissues on computed tomography and motion of fiducial marker near lung cancer.
Onodera Y, Nishioka N, Yasuda K, Fujima N, Torres M, Kamishima T, Ooyama N, Onimaru R, Terae S, Ooizumi S, Nishimura M, Shirato H
Int J Radiat Oncol Biol Phys, 79, 5, 1408, 13, 2011, [Peer-reviewed]

Radiotherapy for glottic T1N0 carcinoma with slight hypofractionation and standard overall treatment time: importance of overall treatment time.
Onimaru R, Hasegawa M, Yasuda K, Homma A, Oridate N, Fukuda S, Shirato H
Jpn J Clin Oncol, 41, 1, 103, 9, 2011, [Peer-reviewed]

Phase I study of concurrent real-time tumor-tracking thoracic radiation therapy with paclitaxel and carboplatin in locally advanced non-small cell lung cancer.
Sakakibara-Konishi J, Oizumi S, Kinoshita I, Shinagawa N, Kikuchi J, Kato M, Inoue T, Katoh N, Onimaru R, Shirato H, Dosaka-Akita H, Nishimura M
Lung Cancer, 74, 2, 248, 52, 2011, [Peer-reviewed]

Optimization of fluoroscopy parameters using pattern matching prediction in the real-time tumor-tracking radiotherapy system.
Miyamoto N, Ishikawa M, Bengua G, Sutherland K, Suzuki R, Kimura S, Shimizu S, Onimaru R, Shirato H
Phys Med Biol, 56, 15, 4803, 13, 2011, [Peer-reviewed], [International Magazine]
English, Scientific journal, In the real-time tumor-tracking radiotherapy system, fluoroscopy is used to determine the real-time position of internal fiducial markers. The pattern recognition score (PRS) ranging from 0 to 100 is computed by a template pattern matching technique in order to determine the marker position on the fluoroscopic image. The PRS depends on the quality of the fluoroscopic image. However, the fluoroscopy parameters such as tube voltage, current and exposure duration are selected manually and empirically in the clinical situation. This may result in an unnecessary imaging dose from the fluoroscopy or loss of the marker because of too much or insufficient x-ray exposure. In this study, a novel optimization method is proposed in order to minimize the fluoroscopic dose while keeping the image quality usable for marker tracking. The PRS can be predicted in a region where the marker appears to move in the fluoroscopic image by the proposed method. The predicted PRS can be utilized to judge whether the marker can be tracked with accuracy. In this paper, experiments were performed to show the feasibility of the PRS prediction method under various conditions. The predicted PRS showed good agreement with the measured PRS. The root mean square error between the predicted PRS and the measured PRS was within 1.44. An experiment using a motion controller and an anthropomorphic chest phantom was also performed in order to imitate a clinical fluoroscopy situation. The result shows that the proposed prediction method is expected to be applicable in a real clinical situation.

Concomitant weekly cisplatin and radiotherapy for head and neck cancer.
Homma A, Inamura N, Oridate N, Suzuki S, Hatakeyama H, Mizumachi T, Kano S, Sakashita T, Onimaru R, Yasuda K, Shirato H, Fukuda S
Jpn J Clin Oncol, 41, 8, 980, 6, 2011, [Peer-reviewed]

Accurate analysis of the change in volume, location, and shape of metastatic cervical lymph nodes during radiotherapy.
Takao S, Tadano S, Taguchi H, Yasuda K, Onimaru R, Ishikawa M, Bengua G, Suzuki R, Shirato H
Int J Radiat Oncol Biol Phys, 81, 3, 871, 9, 2011, [Peer-reviewed]

Organ-conserving Definitive Radiotherapy For Locally Advanced Bladder Carcinoma With Image-guided Local Boost
Nishioka K, Shimizu S, Osaka Y, Kitamura K, Onimaru R, Sazawa A, Harabayashi T, Shinohara N, Shirato H
International Journal of Radiation Oncology Biology Physics, 81, 2, S449, 2011, [Peer-reviewed]

Diffusion tensor imaging characteristics of normal human cervical spinal cord at 3T
Tha KK, Terae S, Ishizaka K, Okuaki T, Hirotani M, Fujima N, Tsukahara A, Shirato H
日本磁気共鳴医学会雑誌, 31, 1, 70, 70, 2011, [Invited]
Japanese

Contrast-Enhanced Whole-Body Joint MRI in Patients With Unclassified Arthritis Who Develop Early Rheumatoid Arthritis Within 2 Years: Feasibility Study and Correlation With MRI Findings of the Hands
Tamotsu Kamishima, Yuichiro Fujieda, Tatsuya Atsumi, Rie Mimura, Takao Koike, Satoshi Terae, Hiroki Shirato
AMERICAN JOURNAL OF ROENTGENOLOGY, 195, 4, W287, W292, Oct. 2010, [Peer-reviewed]
English, Scientific journal

乳房温存療法後局所再発症例の検討
木下留美子, 清水伸一, 土屋和彦, 加藤徳雄, 田口大志, 高橋将人, 高橋弘昌, 白土博樹
日本医学放射線学会秋季臨床大会抄録集, 46th, S506, 25 Aug. 2010
Japanese

Stage C前立腺癌の治療成績—動体追跡強度変調放射線療法と前立腺全摘除術の比較—
丸山覚, 篠原信雄, 安部崇重, 佐澤陽, 原林透, 清水伸一, 白土博樹, 野々村克也
泌尿器外科, 23, 8, 1105-1107, 15 Aug. 2010
Japanese

RADIATION PNEUMONITIS AFTER HYPOFRACTIONATED RADIOTHERAPY: EVALUATION OF THE LQ(L) MODEL AND DIFFERENT DOSE PARAMETERS
Gerben R. Borst, Masayori Ishikawa, Jasper Nijkamp, Michael Hauptmann, Hirk Shirato, Gerard Bengua, Rikiya Onimaru, A. de Josien Bois, Joos V. Lebesque, Jan-Jakob Sonke
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 77, 5, 1596, 1603, Aug. 2010, [Peer-reviewed]
English, Scientific journal

Clinical Outcomes of Stereotactic Brain and/or Body Radiotherapy for Patients with Oligometastatic Lesions
Tetsuya Inoue, Norio Katoh, Hidefumi Aoyama, Rikiya Onimaru, Hiroshi Taguchi, Shunsuke Onodera, Satoshi Yamaguchi, Hiroki Shirato
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 40, 8, 788, 794, Aug. 2010, [Peer-reviewed]
English, Scientific journal

Image-guided adaptive gating of lung cancer radiotherapy: a computer simulation study
Michalis Aristophanous, Joerg Rottmann, Sang-June Park, Seiko Nishioka, Hiroki Shirato, Ross I. Berbeco
PHYSICS IN MEDICINE AND BIOLOGY, 55, 15, 4321, 4333, Aug. 2010, [Peer-reviewed]
English, Scientific journal

生物学的効果を考慮した治療計画—Dose Volume Histogram解析による考察—
関原和正, 石川正純, SUTHERLAND Kenneth, BENGUA Gerard, 宮本直樹, 鈴木隆介, 清水伸一, 白土博樹
Jpn J Radiol, 28, Supplement 1, 15, 15, (公社)日本医学放射線学会, 25 Jul. 2010
Japanese

口唇癌の放射線治療のretrospective study
香泉和寿, 安田耕一, 長谷川雅一, 鬼丸力也, 清水伸一, 木下留美子, 井上哲也, 加藤徳雄, 小野寺俊輔, 田口大志, 溝口史樹, 青山英史, 白土博樹, 西岡健, 武島嗣英
Jpn J Radiol, 28, Supplement 1, 7, 7, (公社)日本医学放射線学会, 25 Jul. 2010
Japanese

PET‐CTを用いた放射線治療計画
藤野賢治, 小野寺俊輔, 清水伸一, 白土博樹, 真鍋治, 伊藤和夫, 細川正夫
Jpn J Radiol, 28, Supplement 1, 8, 25 Jul. 2010
Japanese

The impact of 18F-fluoromisonidazole PET for H&N cancer and the applying for IMRT
YASUDA KOICHI, HASEGAWA MASAICHI, ONIMARU RIKIYA, KINOSHITA RUMIKO, KATO NORIO, TAGUCHI HIROSHI, SHIMIZU SHIN'ICHI, INOUE TETSUYA, ONODERA SHUNSUKE, MIZOGUCHI FUMIKI, AOYAMA HIDEFUMI, SHIRATO HIROKI, SHIGA SATORU, OKAMOTO SHOZO, TAMAKI NAGARA, ISHIKAWA MASAZUMI, SUTHERLAND KENNETH, BENGUA GERARD, MIYAMOTO NAOKI, SUZUKI TAKASUKE
Jpn J Radiol, 28, Supplement 1, 14, 14, (公社)日本医学放射線学会, 25 Jul. 2010
Japanese

Splenic volume measurements on computed tomography utilizing automatically contouring software and its relationship with age, gender, and anthropometric parameters
Ardene Harris, Tamotsu Kamishima, Hong Yi Hao, Fumi Kato, Tokuhiko Omatsu, Yuya Onodera, Satoshi Terae, Hiroki Shirato
EUROPEAN JOURNAL OF RADIOLOGY, 75, 1, E97, E101, Jul. 2010, [Peer-reviewed]
English, Scientific journal

Cesium Implant for Tongue Carcinoma with a Thickness of 1.5 cm or More: Cases Successfully Treated with a Modified Manchester System
Takeshi Nishioka, Masaharu Fujino, Akihiro Homma, Tetsuro Yamashita, Akira Sato, Keiichi Ohmori, Kenichi Obinata, Hiroki Shirato, Kenichi Notani, Masamichi Nishio
YONSEI MEDICAL JOURNAL, 51, 4, 557, 561, Jul. 2010, [Peer-reviewed]
English, Scientific journal

放射線がん治療における免疫系の役割と治療への応用　　　　　　　　　　　　　　　
武島 嗣英, 茶本 健司, 北村 秀光, 西村 孝司, 青山 英史, 白土 博樹
Japanese Journal of Radiology, 28, Suppl.I, 8, 8, (公社)日本医学放射線学会, Jul. 2010
Japanese

放射線がん治療における免疫系の役割と治療への応用　　　　　　　　　　　　　　　
武島 嗣英, 茶本 健司, 北村 秀光, 西村 孝司, 青山 英史, 白土 博樹
Japanese Journal of Radiology, 28, Suppl.I, 8, 8, (公社)日本医学放射線学会, Jul. 2010
Japanese

Remote Desktopアプリケーションを用いた遠隔放射線治療計画システム(第一報)　　　　　　　　　　　　　　　
鈴木 恵士郎, 島 勝美, 西尾 正道, 青山 英史, 白土 博樹, 影井 兼司, 八重樫 祐司, 平澤 之規, 宮坂 和男, 宮本 英樹
Japanese Journal of Radiology, 28, Suppl.I, 8, 8, (公社)日本医学放射線学会, Jul. 2010
Japanese

Inferior phrenic artery-pulmonary vasculature shuntの塞栓によりTACEを施行し得たHCCの1例　　　　　　　　　　　　　　　
作原 祐介, 阿保 大介, 長谷川 悠, 加茂 武実, 清水 匡, 白土 博樹
Japanese Journal of Radiology, 28, Suppl.I, 6, 6, (公社)日本医学放射線学会, Jul. 2010
Japanese

EVALUATION OF THE EFFECTIVENESS OF THE STEREOTACTIC BODY FRAME IN REDUCING RESPIRATORY INTRAFRACTIONAL ORGAN MOTION USING THE REAL-TIME TUMOR-TRACKING RADIOTHERAPY SYSTEM
Gerard Bengua, Masayori Ishikawa, Kenneth Sutherland, Kenji Horita, Rie Yamazaki, Katsuhisa Fujita, Rikiya Onimaru, Noriwo Katoh, Tetsuya Inoue, Shunsuke Onodera, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 77, 2, 630, 636, Jun. 2010, [Peer-reviewed]
English, Scientific journal

Integrin beta 1-dependent invasive migration of irradiation-tolerant human lung adenocarcinoma cells in 3D collagen matrix
Seiichiro Ishihara, Hisashi Haga, Motoaki Yasuda, Takeomi Mizutani, Kazushige Kawabata, Hiroki Shirato, Takeshi Nishioka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 396, 3, 651, 655, Jun. 2010, [Peer-reviewed]
English, Scientific journal

Site-specific volumetric analysis of lung tumour motion
Eric W. Pepin, Huanmei Wu, George A. Sandison, Mark Langer, Hiroki Shirato
PHYSICS IN MEDICINE AND BIOLOGY, 55, 12, 3325, 3337, Jun. 2010, [Peer-reviewed]
English, Scientific journal

Semi-quantitative analysis of rheumatoid finger joint synovitis using power Doppler ultrasonography: when to perform follow-up study after treatment consisting mainly of antitumor necrosis factor alpha agent
Tamotsu Kamishima, Akira Sagawa, Kazuhide Tanimura, Masato Shimizu, Megumi Matsuhashi, Masahide Shinohara, Hiromi Hagiwara, Mihoko Henmi, Akihiro Narita, Satoshi Terae, Hiroki Shirato
SKELETAL RADIOLOGY, 39, 5, 457, 465, May 2010, [Peer-reviewed]
English, Scientific journal

64-Slice MDCT imaging of endocardial cushion defect associated with other cardiac and extracardiac abnormalities
Noriko Oyama, Daisuke Goto, Tsukasa Sasaki, Hiroyuki Tsutsui, Nagara Tamaki, Satoshi Terae, Hiroki Shirato
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, 4, 3, 218, 220, May 2010, [Peer-reviewed]
English, Scientific journal

Extramedullary plasmacytoma involving perirenal space accompanied by extramedullary hematopoiesis and amyloid deposition
Rie Mimura, Tamotsu Kamishima, Kanako C. Kubota, Fumihito Nakano, Ichiro Yabe, Hidenao Sasaki, Satoru Maruyama, Nobuo Shinohara, Ardene A. Harris, Hironori Haga, Hiroki Shirato, Satoshi Terae
Japanese Journal of Radiology, 28, 4, 309, 313, 4, May 2010, [Peer-reviewed]
English, Scientific journal

膵頭十二指腸切除後に発症した上腸間膜動脈仮性瘤に対してcovered stent留置にて止血し得た1例
三浦 巧, 平野 聡, 川村 武史, 斉藤 博紀, 中山 智英, 松井 あや, 加藤 健太郎, 川崎 亮輔, 松本 譲, 土川 貴裕, 七戸 俊明, 田中 栄一, 近藤 哲, 阿保 大介, 作原 祐介, 白土 博樹
日本臨床外科学会雑誌, 71, 5, 1375, 1375, 日本臨床外科学会, May 2010
Japanese

化学放射線治療後の頸部郭清の必要性について　　　　　　　　　　　　　　　
本間 明宏, 折舘 伸彦, 鈴木 章之, 鈴木 清護, 原 敏浩, 加納 里志, 水町 貴諭, 古沢 純, 稲村 直哉, 福田 諭, 吉田 大介, 鬼丸 力也, 安田 耕一, 白土 博樹
頭頸部癌, 36, 2, 191, 191, (一社)日本頭頸部癌学会, May 2010
Japanese

頭頸部癌に対するweekly cisplatinと放射線同時併用療法の検討　　　　　　　　　　　　　　　
稲村 直哉, 本間 明宏, 折舘 伸彦, 鈴木 清護, 鈴木 章之, 原 敏浩, 真栄田 裕行, 加納 里志, 水町 貴諭, 福田 諭, 鬼丸 力也, 長谷川 雅一, 安田 耕一, 白土 博樹
頭頸部癌, 36, 2, 206, 206, (一社)日本頭頸部癌学会, May 2010
Japanese

Local Radiation Therapy Inhibits Tumor Growth through the Generation of Tumor-Specific CTL: Its Potentiation by Combination with Th1 Cell Therapy
Tsuguhide Takeshima, Kenji Chamoto, Daiko Wakita, Takayuki Ohkuri, Yuji Togashi, Hiroki Shirato, Hidemitsu Kitamura, Takashi Nishimura
CANCER RESEARCH, 70, 7, 2697, 2706, Apr. 2010, [Peer-reviewed]
English, Scientific journal

診断X線領域における極微小光ファイバ線量計の基礎特性評価　　　　　　　　　　　　　　　
江口 菜弥帆, 石川 正純, 作原 祐介, 阿保 大介, 太田 真緒, Sutherland Kenneth, 白土 博樹
日本放射線技術学会総会学術大会予稿集, 66回, 153, 154, (公社)日本放射線技術学会, Feb. 2010
Japanese

Detection of Normal Spinal Veins by Using Susceptibility-Weighted Imaging
Kinya Ishizaka, Kohsuke Kudo, Noriyuki Fujima, Yuri Zaitsu, Rie Yazu, Khin Khin Tha, Satoshi Terae, E. Mark Haacke, Makoto Sasaki, Hiroki Shirato
JOURNAL OF MAGNETIC RESONANCE IMAGING, 31, 1, 32, 38, Jan. 2010, [Peer-reviewed]
English, Scientific journal

Differences in CT Perfusion Maps Generated by Different Commercial Software: Quantitative Analysis by Using Identical Source Data of Acute Stroke Patients
Kohsuke Kudo, Makoto Sasaki, Kei Yamada, Suketaka Momoshima, Hidetsuna Utsunomiya, Hiroki Shirato, Kuniaki Ogasawara
RADIOLOGY, 254, 1, 200, 209, Jan. 2010, [Peer-reviewed]
English, Scientific journal

High Dose Three-Dimensional Conformal Boost Using the Real-Time Tumor Tracking Radiotherapy System in Cervical Cancer Patients Unable to Receive Intracavitary Brachytherapy
Hee Chul Park, Shinichi Shimizu, Akio Yonesaka, Kazuhiko Tsuchiya, Yasuhiko Ebina, Hiroshi Taguchi, Norio Katoh, Rumiko Kinoshita, Masayori Ishikawa, Noriaki Sakuragi, Hiroki Shirato
YONSEI MEDICAL JOURNAL, 51, 1, 93, 99, Jan. 2010, [Peer-reviewed]
English, Scientific journal

Metastases in Mediastinal and Hilar Lymph Nodes in Patients With Non-Small Cell Lung Cancer: Quantitative Assessment With Diffusion-Weighted Magnetic Resonance Imaging and Apparent Diffusion Coefficient
Jun Nakayama, Kazuo Miyasaka, Tokuhiko Omatsu, Yunya Onodera, Satoshi Terae, Yoshihiro Matsuno, Yasushi Cho, Yasuhiro Hida, Kichizo Kaga, Hiroki Shirato
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 34, 1, 1, 8, Jan. 2010, [Peer-reviewed]
English, Scientific journal

Susceptibility-weighted imaging of cerebral fat embolism.
Yuri Zaitsu, Satoshi Terae, Kohsuke Kudo, Khin Khin Tha, Mineji Hayakawa, Noriyuki Fujima, Daisuke Yoshida, Akiko Tsukahara, Hiroki Shirato
Journal of computer assisted tomography, 34, 1, 107, 12, 1, Jan. 2010, [Peer-reviewed], [International Magazine]
English, Scientific journal, Cerebral fat embolism (CFE) causes microinfarcts, vasogenic edema, and petechiae in the brain. Conventional magnetic resonance imaging has been reported to effectively visualize microinfarcts and vasogenic edema in CFE, but not petechiae. We report 3 cases of CFE in which susceptibility-weighted imaging distinctly demonstrated multiple minute hypointense foci in the brain, which were interpreted as petechiae, susceptibility-weighted imaging is a useful adjunct to conventional magnetic resonance imaging for the evaluation of CFE.

Evaluation of the need for simultaneous orthogonal gated setup imaging
Ross I. Berbeco, Seiko Nishioka, Hiroki Shirato
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 11, 2, 158, 167, 2010, [Peer-reviewed]
English, Scientific journal

A parameter study of pencil beam proton dose distributions for the treatment of ocular melanoma utilizing spot scanning
Kenneth Sutherland, Satoshi Miyajima, Hiroyuki Date, Hiroki Shirato, Masayori Ishikawa, Masao Murakami, Mitsuru Yamagiwa, Paul Bolton, Toshiki Tajima
Radiological Physics and Technology, 3, 1, 16, 22, 1, Jan. 2010, [Peer-reviewed]
English, Scientific journal

An Internationally Compatible, Japanese Neurocognitive Function Test Battery for the Assessment of Radiation-induced Brain Injury
S. Onodera, H. Aoyama, N. Hashimoto, A. Toyomaki, N. Nishikawa, K. K. Tha, K. Ogisu, S. Terae, H. Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 78, 3, S293, S293, 2010, [Peer-reviewed]
English

Radiation pneumonitis after hypofractionated radiotherapy: evaluation of the LQ(L) model and different dose parameters.
Borst G. R, Ishikawa M, Nijkamp J, Hauptmann M, Shirato H, Bengua G, Onimaru R, de Josien Bois A, Lebesque J. V, Sonke J. J
Int J Radiat Oncol Biol Phys, 77, 5, 1596, 603, 2010, [Peer-reviewed]

Clinical outcomes of stereotactic brain and/or body radiotherapy for patients with oligometastatic lesions.
Inoue T, Katoh N, Aoyama H, Onimaru R, Taguchi H, Onodera S, Yamaguchi S, Shirato H
Jpn J Clin Oncol, 40, 8, 788, 94, 2010, [Peer-reviewed]

MultiTransmitを用いた3.0T乳腺MRI　　　　　　　　　　　　　　　
加藤扶美, 石坂欣也, 小原真, 大山徳子, 水戸寿々子, 寺江聡, 白土博樹
映像情報Medical, 42, 94, 99, 2010

臨床的に原発性肺癌と診断された病理組織診断のつかない小型肺腫瘍に対する体幹部定位放射線治療
井上哲也, 清水伸一, 鬼丸力也, 白土博樹, 武田篤也, 大西洋, 永田靖, 木村智樹, 唐澤克之, 有本卓郎, 晴山雅人, 菊地英毅
肺癌, 49, 7, 1057, 20 Dec. 2009
Japanese

乳房温存手術後接線照射における被照射腋窩リンパ節領域の検討
田口大志, 清水伸一, 木下留美子, 白土博樹, 高橋弘昌, 高橋將人, 細田充主, 藤堂省
北海道外科雑誌, 54, 2, 188, 20 Dec. 2009
Japanese

STEREOTACTIC RADIOTHERAPY FOR INTRACRANIAL NONACOUSTIC SCHWANNOMAS INCLUDING FACIAL NERVE SCHWANNOMA
Kentaro Nishioka, Daisuke Abo, Hidefumi Aoyama, Yasushi Furuta, Rikiya Onimaru, Shunsuke Onodera, Yutaka Sawamura, Masayori Ishikawa, Satoshi Fukuda, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75, 5, 1415, 1419, Dec. 2009, [Peer-reviewed]
English, Scientific journal

尿路性器癌に対する放射線療法 放射線療法による合併症を減らすための最新の工夫
篠原信雄, 丸山覚, 安部崇重, 佐澤陽, 清水伸一, 白土博樹
Urol View, 7, 6, 15-20, 01 Dec. 2009
Japanese

CLINICAL OUTCOMES OF STEREOTACTIC BODY RADIOTHERAPY FOR SMALL LUNG LESIONS CLINICALLY DIAGNOSED AS PRIMARY LUNG CANCER ON RADIOLOGIC EXAMINATION
Tetsuya Inoue, Shinichi Shimizu, Rikiya Onimaru, Atsuya Takeda, Hiroshi Onishi, Yasushi Nagata, Tomoki Kimura, Katsuyuki Karasawa, Takuro Arimoto, Masato Hareyama, Elki Kikuchi, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75, 3, 683, 687, Nov. 2009, [Peer-reviewed]
English, Scientific journal

Outcome of MR-guided percutaneous cryoablation for hepatocellular carcinoma
Tadashi Shimizu, Yusuke Sakuhara, Daisuke Abo, Yu Hasegawa, Yoshihisa Kodama, Hideho Endo, Hiroki Shirato, Kazuo Miyasaka
JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY, 16, 6, 816, 823, Nov. 2009, [Peer-reviewed]
English, Scientific journal

導入化学療法と低線量放射線治療でジャーミノーマの治療は可能か　　　　　　　　　　　　　　　
澤村 豊, 鴨嶋 雄大, 白土 博樹, 青山 英史
小児がん, 46, プログラム・総会号, 353, 353, (NPO)日本小児がん学会, Nov. 2009
Japanese

放射線治療の現在 I.臨床 動体追跡放射線治療10年の経験
加藤徳雄, 鬼丸力也, 田口大志, 清水伸一, 白土博樹
映像情報Medical, 41, 12, 1222-1227,1207, 1261, 産業開発機構, 01 Nov. 2009
Japanese

Superselective High-Dose Cisplatin Infusion With Concomitant Radiotherapy in Patients With Advanced Cancer of the Nasal Cavity and Paranasal Sinuses A Single Institution Experience
Akihiro Homma, Nobuhiko Oridate, Fumiyuki Suzuki, Shigenari Taki, Takeshi Asano, Daisuke Yoshida, Rikiya Onimaru, Takeshi Nishioka, Hiroki Shirato, Satoshi Fukuda
CANCER, 115, 20, 4705, 4714, Oct. 2009, [Peer-reviewed]
English, Scientific journal

SURVEY OF STEREOTACTIC BODY RADIATION THERAPY IN JAPAN BY THE JAPAN 3-D CONFORMAL EXTERNAL BEAM RADIOTHERAPY GROUP
Yasushi Nagata, Masahiro Hiraoka, Takashi Mizowaki, Yuichiro Narita, Yukinori Matsuo, Yoshiki Norihisa, Hiroshi Onishi, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75, 2, 343, 347, Oct. 2009, [Peer-reviewed]
English, Scientific journal

Can hybrid FDG-PET/CT detect subclinical lymph node metastasis of esophageal cancer appropriately and contribute to radiation treatment planning? A comparison of image-based and pathological findings
Shinichi Shimizu, Masao Hosokawa, Kazuo Itoh, Masahiro Fujita, Hiroaki Takahashi, Hiroki Shirato
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 14, 5, 421, 425, Oct. 2009, [Peer-reviewed]
English, Scientific journal

Intravenous pyogenic granuloma of the finger
Tamotsu Kamishima, Akiko Hasegawa, Kanako C. Kubota, Naomi Oizumi, Norimasa Iwasaki, Akio Minami, Satoru Sasaki, Yuhei Yamamoto, Tokuhiko Omatsu, Yuya Onodera, Satoshi Terae, Hiroki Shirato
JAPANESE JOURNAL OF RADIOLOGY, 27, 8, 328, 332, Oct. 2009, [Peer-reviewed]
English, Scientific journal

強度変調放射線治療(IMRT)の中長期成績 北海道大学病院での頭頸部癌に対する強度変調放射線治療の成績
鬼丸 力也, 長谷川 雅一, 安田 耕一, 木下 留美子, 白土 博樹, 本間 明宏, 折舘 伸彦, 福田 諭
頭頸部癌, 35, 3, 245, 249, (一社)日本頭頸部癌学会, Oct. 2009
Japanese

Volume-rendering and endocardial views of partially unroofed coronary sinus with 64-slice multidetector CT
Noriko Oyama, Tomonori Ooka, Tsukasa Sasaki, Suguru Kubota, Yuya Onodera, Yoshiro Matsui, Satoshi Terae, Hiroki Shirato
Journal of Cardiovascular Computed Tomography, 3, 5, 346, 347, 5, Sep. 2009, [Peer-reviewed]
English, Scientific journal

動体追跡装置におけるコントラスト‐ノイズ比の測定方法の検討
木村傑, 宮本直樹, 石川正純, SUTHERLAND Kenneth, BENGUA Gerard, 鈴木隆介, 清水伸一, 青山英史, 鬼丸力也, 白土博樹
医学物理 Supplement, 29, 3, 148-149, Sep. 2009
Japanese

動体追跡放射線治療におけるX線透視条件の最適化
宮本直樹, SUTHERLAND Kenneth, 石川正純, 鈴木隆介, BENGUA Gerard, 木村傑, 清水伸一, 青山英史, 鬼丸力也, 白土博樹
医学物理 Supplement, 29, 3, 150-151, Sep. 2009
Japanese

臨床的に原発性肺癌と診断された病理診断のつかない小型肺腫瘍に対する定位放射線治療
井上哲也, 清水伸一, 武田篤也, 大西洋, 永田靖, 木村智樹, 唐澤克之, 晴山雅人, 有本卓郎, 白土博樹
日本放射線腫よう学会誌, 21, Supplement 1, 75, 19 Aug. 2009
Japanese

動体追跡装置を用いた肺定位照射時の投与線量解析—動体追跡データに基づくDVH解析—
石川正純, サザランド ケネス, ベングア ジェラード, 鈴木隆介, 宮本直樹, 加藤徳雄, 清水伸一, 鬼丸力也, 青山英史, 白土博樹
日本放射線腫よう学会誌, 21, Supplement 1, 158, 19 Aug. 2009
Japanese

Synchronous monitoring of external/internal respiratory motion: validity of respiration-gated radiotherapy for liver tumors
Takeshi Nishioka, Seiko Nishioka, Masaki Kawahara, Shigeru Tanaka, Hiroki Shirato, Ken Nishi, Tadao Hiromura
JAPANESE JOURNAL OF RADIOLOGY, 27, 7, 285, 289, Aug. 2009, [Peer-reviewed]
English, Scientific journal

新しい治療 画像誘導放射線治療(image‐guided radiotherapy:IGRT)
白土博樹, 青山英史, 鬼丸力也, 清水伸一, 石川正純, 西岡健
治療学, 43, 7, 781-783, 783, ライフサイエンス出版(株), 10 Jul. 2009
Japanese

Value of fluorodeoxyglucose positron emission tomography before radiotherapy for head and neck cancer: does the standardized uptake value predict treatment outcome?
Keishiro Suzuki, Takeshi Nishioka, Akihiro Homma, Kazuhiko Tsuchiya, Motoaki Yasuda, Hidefumi Aoyama, Rikiya Onimaru, Nagara Tamaki, Hiroki Shirato
JAPANESE JOURNAL OF RADIOLOGY, 27, 6, 237, 242, Jul. 2009, [Peer-reviewed]
English, Scientific journal

機能温存をめざした頭頸部癌治療update 強度変調放射線治療(intensity modulated radiotherapy;IMRT)
鬼丸力也, 木下留美子, 長谷川雅一, 安田耕一, 白土博樹
ENTONI, 103, 14, 20, (株)全日本病院出版会, 15 Jun. 2009
Japanese

Radiation pneumonitis in patients treated for malignant pulmonary lesions with hypofractionated radiation therapy
Gerben R. Borst, Masayori Ishikawa, Jasper Nijkamp, Michael Hauptmann, Hiroki Shirato, Rikiya Onimaru, Michel M. van den Heuvel, Jose Belderbos, Joos V. Lebesque, Jan-Jakob Sonke
RADIOTHERAPY AND ONCOLOGY, 91, 3, 307, 313, Jun. 2009, [Peer-reviewed]
English, Scientific journal

Alveolar hydatid disease of the adrenal gland: Computed tomography and magnetic resonance imaging findings
Tamotsu Kamishima, Toru Harabayashi, Syuhei Ishikawa, Kanako C. Kubota, Katsuya Nonomura, Tokuhiko Omatsu, Yuya Onodera, Hiroki Shirato, Satoshi Terae
Japanese Journal of Radiology, 27, 5, 225, 228, 5, Jun. 2009, [Peer-reviewed]
English, Scientific journal

Prediction of three-dimensional tumor shrinkage and deformation from radiotherapy using Linear-Quadratic model and mechanical analogy　　　　　　　　　　　　　　　
Takao, S, Tadano, S, Taguchi, H, Shirato, H
Proceedings of the 8th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, Jun. 2009, [Peer-reviewed]
English, International conference proceedings

Combination immunotherapy with radiation and CpG-based tumor vaccination for the eradication of radio- and immuno-resistant lung carcinoma cells
Kenji Chamoto, Tsuguhide Takeshima, Daiko Wakita, Takayuki Ohkuri, Shigeru Ashino, Tokuhiko Omatsu, Hiroki Shirato, Hidemitsu Kitamura, Yuji Togashi, Takashi Nishimura
CANCER SCIENCE, 100, 5, 934, 939, May 2009, [Peer-reviewed]
English, Scientific journal

Power Doppler ultrasound of rheumatoid synovitis: quantification of vascular signal and analysis of interobserver variability
Tamotsu Kamishima, Kazuhide Tanimura, Mihoko Henmi, Akihiro Narita, Fumihiko Sakamoto, Satoshi Terae, Hiroki Shirato
SKELETAL RADIOLOGY, 38, 5, 467, 472, May 2009, [Peer-reviewed]
English, Scientific journal

Reduction of Bed Rest Time after Transfemoral Noncardiac Angiography from 4 Hours to 2 Hours: A Randomized Trial and a One-arm Study
Fumi Kato, Yukihiko Sato, Noriaki Yuasa, Daisuke Abo, Yusuke Sakuhara, Noriko Oyama, Rikiya Onimaru, Hidefumi Aoyama, Hiroki Shirato, Satoshi Terae
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 20, 5, 587, 592, May 2009, [Peer-reviewed]
English, Scientific journal

Sonazoid-enhanced sonography for guiding radiofrequency ablation for hepatocellular carcinoma: Better tumor visualization by Kupffer-phase imaging and vascular-phase imaging after reinjection
Noriyuki Miyamoto, Kazuhide Hiramatsu, Kazuhiko Tsuchiya, Yukihiko Sato, Satoshi Terae, Hiroki Shirato
Japanese Journal of Radiology, 27, 4, 185, 193, 4, May 2009, [Peer-reviewed]
English, Scientific journal

病理診断のついていない小型肺腫瘍に対する定位放射線治療
井上 哲也, 鬼丸 力也, 清水 伸一, 青山 英史, 白土 博樹
臨床放射線, 54, 5, 625, 630, 金原出版(株), May 2009
Japanese

Sonazoid-enhanced sonography for guiding radiofrequency ablation for hepatocellular carcinoma: better tumor visualization by Kupffer-phase imaging and vascular-phase imaging after reinjection
Noriyuki Miyamoto, Kazuhide Hiramatsu, Kazuhiko Tsuchiya, Yukihiko Sato, Satoshi Terae, Hiroki Shirato
JAPANESE JOURNAL OF RADIOLOGY, 27, 4, 185, 193, May 2009, [Peer-reviewed]
English, Scientific journal

化学放射線療法後の救済手術 問題点とその対策 喉頭下咽頭癌に対する化学放射線療法後の救済手術　　　　　　　　　　　　　　　
鈴木 章之, 本間 明宏, 折舘 伸彦, 鈴木 清護, 水町 貴諭, 加納 里志, 瀧 重成, 稲村 直哉, 鬼丸 力也, 長谷川 雅一, 白土 博樹, 古田 康, 福田 諭
頭頸部癌, 35, 2, 61, 61, (一社)日本頭頸部癌学会, May 2009
Japanese

Alternative approach in the treatment of adrenal metastasis with a real-time tracking radiotherapy in patients with hormone refractory prostate cancer
Ataru Sazawa, Nobuo Shinohara, Toru Harabayashi, Takashige Abe, Hiroki Shirato, Katsuya Nonomura
INTERNATIONAL JOURNAL OF UROLOGY, 16, 4, 410, 412, Apr. 2009, [Peer-reviewed]
English, Scientific journal

転移性脳腫瘍への放射線治療後の認知機能の推移　　　　　　　　　　　　　　　
青山 英史, 加藤 徳雄, 白土 博樹
Japanese Journal of Radiology, 27, Suppl., 12, 12, (公社)日本医学放射線学会, Apr. 2009
Japanese

脊髄AVMにおける磁化率強調画像(SWI)の有用性の検討　　　　　　　　　　　　　　　
藤間 憲幸, 工藤 興亮, Tha Khin Khin, 塚原 亜希子, 寺江 聡, 白土 博樹
Japanese Journal of Radiology, 27, Suppl., 4, 4, (公社)日本医学放射線学会, Apr. 2009
Japanese

多発性嚢胞腎に対する動脈塞栓術の治療成績　　　　　　　　　　　　　　　
作原 祐介, 阿保 大介, 長谷川 悠, 藤田 希実, 白土 博樹, 清水 匡
IVR: Interventional Radiology, 24, 2, 187, 187, (一社)日本インターベンショナルラジオロジー学会, Apr. 2009
Japanese

EPIR-Lipiodol懸濁液を用いた肝TAI or TACEによるHCC局所制御率　　　　　　　　　　　　　　　
阿保 大介, 藤田 希実, 長谷川 悠, 作原 祐介, 白土 博樹, 清水 匡
IVR: Interventional Radiology, 24, 2, 187, 187, (一社)日本インターベンショナルラジオロジー学会, Apr. 2009
Japanese

EPIR-Lipiodol懸濁液を用いた肝TAI or TACEによるHCCの合併症　　　　　　　　　　　　　　　
藤田 希実, 阿保 大介, 長谷川 悠, 作原 祐介, 白土 博樹, 清水 匡
IVR: Interventional Radiology, 24, 2, 187, 187, (一社)日本インターベンショナルラジオロジー学会, Apr. 2009
Japanese

対向型PET装置を用いた分子イメージング動体追跡装置の開発〜¹⁸F点線源を用いた追跡精度の検証〜
棚邊哲史, 石川正純, 山口哲, 武島嗣英, 鈴木隆介, 宮本直樹, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹
医学物理 Supplement, 29, 2, 101-102, Apr. 2009
Japanese

体内臓器同期照射を目的とした次世代動体追跡装置の開発〜透視画像の歪みと位置計算誤差〜
宮本直樹, SUTHERLAND Kenneth, 石川正純, 鈴木隆介, BENGUA Gerard, 木村傑, 清水伸一, 青山英史, 鬼丸力也, 白土博樹
医学物理 Supplement, 29, 2, 192-193, Apr. 2009
Japanese

体内臓器同期照射を目的とした次世代動体追跡装置の開発〜デジタル画像機器としての定量的評価〜
木村傑, 石川正純, SUTHERLAND Kenneth, 宮本直樹, BENGUA Gerard, 鈴木隆介, 清水伸一, 青山英史, 鬼丸力也, 白土博樹
医学物理 Supplement, 29, 2, 196-197, Apr. 2009
Japanese

体内臓器同期照射を目的とした次世代動体追跡装置の開発〜複数マーカ追跡への挑戦〜
石川正純, SUTHERLAND Kenneth, 宮本直樹, BENGUA Gerard, 清水伸一, 青山英史, 鬼丸力也, 木村傑, 白土博樹
医学物理 Supplement, 29, 2, 194-195, Apr. 2009
Japanese

Difference in CT Perfusion Maps among Commercially Available Software: Quantitative Analysis Using Identical Source Data of Acute Stroke Patients
Kudo Kohsuke, Sasaki Makoto, Yamada Kei, Momoshima Suketaka, Kuroiwa Taizo, Utsunomiya Hidetsuna, Shirato Hiroki, Ogasawara Kuniaki
STROKE, 40, 4, E114, Apr. 2009, [Peer-reviewed]

限局性前立腺癌のQOL評価を含む治療成績〜動体追跡強度変調放射線療法と前立腺全摘除術の比較〜
丸山覚, 篠原信雄, 安部崇重, 原林透, 佐澤陽, 清水伸一, 白土博樹, 野々村克也
泌尿器外科, 22, 349, 15 Mar. 2009
Japanese

上咽頭癌における半導体PET画像を用いた放射線治療計画
加藤徳雄, 志賀哲, 長谷川雅一, 鬼丸力也, 安田耕一, 清水伸一, ベングア ジェラード, 石川正純, 玉木長良, 白土博樹
日本医学放射線学会総会抄録集, 68th, S307-S308, S308, (公社)日本医学放射線学会, 28 Feb. 2009
Japanese

A New PET Scanner with Semiconductor Detectors Enables Better Identification of Intratumoral Inhomogeneity
Tohru Shiga, Yuichi Morimoto, Naoki Kubo, Norio Katoh, Chietsugu Katoh, Wataru Takeuchi, Reiko Usui, Kenji Hirata, Shinichi Kojima, Kikuo Umegaki, Hiroki Shirato, Nagara Tamaki
JOURNAL OF NUCLEAR MEDICINE, 50, 1, 148, 155, Jan. 2009, [Peer-reviewed]
English, Scientific journal

Novel Function of Transcription Factor ATF5: Blockade of p53-dependent Apoptosis Induced by Ionizing Irradiation
Takeshi Nishioka, Yusuke Miyai, Hisashi Haga, Kazushige Kawabata, Hiroki Shirato, Akihiro Homma, Kenichiro Shibata, Motoaki Yasuda
CELL STRUCTURE AND FUNCTION, 34, 1, 17, 22, 2009, [Peer-reviewed]
English, Scientific journal

Increased Motility and Invasiveness in Tumor Cells That Survive 10 Gy Irradiation
Kaori Tsutsumi, Masumi Tsuda, Natsuka Yazawa, Hirotaka Nakamura, Seiichiro Ishihara, Hisashi Haga, Motoaki Yasuda, Rie Yamazaki, Hiroki Shirato, Hideaki Kawaguchi, Takeshi Nishioka, Yusuke Ohba
CELL STRUCTURE AND FUNCTION, 34, 2, 89, 96, 2009, [Peer-reviewed]
English, Scientific journal

A web-based remote radiation treatment planning system using the remote desktop function of a computer operating system: a preliminary report
Keishiro Suzuki, Yukinori Hirasawa, Yuji Yaegashi, Hideki Miyamoto, Hiroki Shirato
JOURNAL OF TELEMEDICINE AND TELECARE, 15, 8, 414, 418, 2009, [Peer-reviewed]
English, Scientific journal

A new PET scanner with semiconductor detector reveals intratumoral inhomogeneous cell activity with high spatial and energy resolution　　　　　　　　　　　　　　　
Shiga T, Kubo N, Morimoto Y, Katoh N, Katoh C, Ueno Y, Hirata K, Usui R, Kobayashi K, Takeuchi W, Shirato H, Tamaki N
Molecular Imaging for Integrated Medical Therapy and Drug Development, 42, 51, 2009
English, International conference proceedings

Gating based on internal/external signals with dynamic correlation updates
Huanmei Wu, Qingya Zhao, Ross I. Berbeco, Seiko Nishioka, Hiroki Shirato, Steve B. Jiang
PHYSICS IN MEDICINE AND BIOLOGY, 53, 24, 7137, 7150, Dec. 2008, [Peer-reviewed]
English, Scientific journal

Surgical complications of salvage total laryngectomy following concurrent chemoradiotherapy
Yasushi Furuta, Akihiro Homma, Nobuhiko Oridate, Fumiyuki Suzuki, Hiromitsu Hatakeyama, Keishiro Suzuki, Takeshi Nishioka, Hiroki Shirato, Satoshi Fukuda
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 13, 6, 521, 527, Dec. 2008, [Peer-reviewed]
English, Scientific journal

Late recurrence and salvage therapy of CNS germinomas
Yuuta Kamoshima, Yutaka Sawamura, Jun Ikeda, Hiroki Shirato, Hidefumi Aoyama
JOURNAL OF NEURO-ONCOLOGY, 90, 2, 205, 211, Nov. 2008, [Peer-reviewed]
English, Scientific journal

Splenic Peliosis Mimicking a Solid Tumor: Findings in Multimodalities
Daisuke Abo, Satoshi Terae, Yuichiro Fukasawa, Hideyuki Seki, Yu Hasegawa, Yusuke Sakuhara, Tadashi Shimizu, Hiroki Shirato
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 32, 6, 890, 892, Nov. 2008, [Peer-reviewed]
English, Scientific journal

Double microcatheter+IDC使用によるpinpointでの血流遮断術　　　　　　　　　　　　　　　
阿保 大介, 長谷川 悠, 作原 祐介, 白土 博樹, 清水 匡
IVR: Interventional Radiology, 23, 4, 403, 404, (一社)日本インターベンショナルラジオロジー学会, Oct. 2008
Japanese

Inferior phrenic artery-pulmonary vasculature shuntの塞栓によりTACEを施行し得たHCCの1例　　　　　　　　　　　　　　　
作原 祐介, 阿保 大介, 長谷川 悠, 加茂 武実, 清水 匡, 白土 博樹
IVR: Interventional Radiology, 23, 4, 405, 405, (一社)日本インターベンショナルラジオロジー学会, Oct. 2008
Japanese

75歳以上の高齢者に対する子宮頚癌の放射線治療
木下留美子, 田口大志, 加藤徳雄, 清水伸一, 溝口史樹, 米坂祥朗, 北原利博, 白土博樹
日本放射線腫よう学会誌, 20, Supplement 1, 146, 22 Sep. 2008
Japanese

Evaluation of the vascular supply to regions of the pancreas on CT during arteriography
Yusuke Sakuhara, Yoshihisa Kodama, Daisuke Abo, Yu Hasegawa, Tadashi Shimizu, Tokuhiko Omatsu, Tamotsu Kamishika, Yuya Onodera, Satoshi Terae, Hiroki Shirato
ABDOMINAL IMAGING, 33, 5, 563, 570, Sep. 2008, [Peer-reviewed]
English, Scientific journal

De novo formation of cavernoma after radiosurgery for adult cerebral arteriovenous malformation - Case report
Hiroaki Motegi, Satoshi Kuroda, Nobuaki Ishii, Hidefumi Aoyama, Satoshi Terae, Hiroki Shirato, Yoshinobu Iwasaki
NEUROLOGIA MEDICO-CHIRURGICA, 48, 9, 397, 400, Sep. 2008, [Peer-reviewed]
English, Scientific journal

Low-dose craniospinal irradiation and ifosfamide, cisplatin and etoposide for non-metastatic embryonal tumors in the central nervous system
Koichi Yasuda, Hiroshi Taguchi, Yutaka Sawamura, Jun Ikeda, Hidefumi Aoyama, Kenji Fujieda, Nobuaki Ishii, Masaaki Kashiwamura, Yoshinobu Iwasaki, Hiroki Shirato
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 38, 7, 486, 492, Jul. 2008, [Peer-reviewed]
English, Scientific journal

CT/MRIにて確定診断に至らなかった結節に対する造影超音波(CEUS)の位置づけ　　　　　　　　　　　　　　　
西田 睦, 増田 香織, 佐藤 恵美, 溝口 恵美, 小野寺 祐也, 尾松 徳彦, 神島 保, 加藤 扶美, 加賀 早苗, 井上 真美子, 横山 しのぶ, 鈴木 春樹, 清水 力, 松野 一彦, 玉木 長良, 白土 博樹
超音波医学, 35, 4, 463, 463, (公社)日本超音波医学会, Jul. 2008
Japanese

UAE後にsloughing fibroidを生じた1例　　　　　　　　　　　　　　　
作原 祐介, 阿保 大介, 長谷川 悠, 清水 匡, 白土 博樹, 木村 広幸
IVR: Interventional Radiology, 23, 3, 313, 313, (一社)日本インターベンショナルラジオロジー学会, Jul. 2008
Japanese

肝移植後膵液瘻による合併症に対し複合的IVRが奏功した1例　　　　　　　　　　　　　　　
長谷川 悠, 阿保 大介, 佐原 祐介, 白土 博樹, 清水 匡, 嶋村 剛, 古川 博之, 桑谷 将城, 河上 洋
IVR: Interventional Radiology, 23, 3, 316, 316, (一社)日本インターベンショナルラジオロジー学会, Jul. 2008
Japanese

Real-time tumor-tracking radiotherapy for adrenal tumors
Norio Katoh, Rikiya Onimaru, Yusuke Sakuhara, Daisuke Abo, Shinichi Shimizu, Hiroshi Taguchi, Yoshiaki Watanabe, Nobuo Shinohara, Masayori Ishikawa, Hiroki Shirato
RADIOTHERAPY AND ONCOLOGY, 87, 3, 418, 424, Jun. 2008, [Peer-reviewed]
English, Scientific journal

Frontiers of Three-dimensional Conformal Radiation Therapy: Image-guided Radiation Therapy and Four-dimensional Radiation Therapy
KINOSHITA RUMIKO, ONODERA YUYA, SHIRATO HIROKI, SHIMIZU SHIN'ICHI, ONIMARU RIKIYA, AOYAMA HIDEFUMI
画像診断, 28, 6, 560-566, 566, (株)学研メディカル秀潤社, 25 Apr. 2008
Japanese

全身造影MRIによる関節リウマチの画像診断　　　　　　　　　　　　　　　
神島 保, 白土 博樹, 保田 晋介, 堀田 哲也, 渥美 達也, 小池 隆夫
Radiation Medicine, 26, Suppl.I, 11, 11, (公社)日本医学放射線学会, Apr. 2008
Japanese

Intramedullary spinal cord metastasis treated with radiation therapy: Report of 3 cases
Shogo Endo, Kazutoshi Hida, Shunsuke Yano, Masaki Ito, Shigeru Yamaguchi, Daina Kashiwazaki, Rumiko Kinoshita, Hiroki Shirato, Yoshinobu Iwasaki
NEUROLOGICAL SURGERY, 36, 4, 345, 349, Apr. 2008, [Peer-reviewed]
Japanese, Scientific journal

64列および4列のCT angiographyでの肝移植ドナーにおける肝動脈描出能の比較検討　　　　　　　　　　　　　　　
藤間 憲幸, 小野寺 祐也, 白土 博樹
Radiation Medicine, 26, Suppl.I, 13, 13, (公社)日本医学放射線学会, Apr. 2008
Japanese

[非小細胞肺癌]画像誘導放射線治療と強度変調放射線治療
白土博樹, 鬼丸力也, 石川正純, 田口大志, 加藤徳雄, 清水伸一
MOOK肺癌の臨床, 2008-2009, 319-326, 31 Mar. 2008
Japanese

Three-dimensional intrafractional motion of breast during tangential breast irradiation monitored with high-sampling frequency using a real-time tumor-tracking radiotherapy system
Rumiko Kinoshita, Shinichi Shimizu, Hiroshi Taguchi, Norio Katoh, Masaharu Fujino, Rikiya Onimaru, Hidefumi Aoyama, Fumi Katoh, Tokuhiko Omatsu, Masayori Ishikawa, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 70, 3, 931, 934, Mar. 2008, [Peer-reviewed]
English, Scientific journal

病理診断のついていない小型肺癌に対する定位放射線治療の安全性及び有用性の検討
井上哲也, 鬼丸力也, 清水伸一, 武田篤也, 有本卓郎, 平岡眞寛, 山田章吾, 白土博樹
日本医学放射線学会総会抄録集, 67th, S193-S194, 28 Feb. 2008
Japanese

動態追跡照射時の肺腫瘍の動きに関連する因子の検討
小野寺祐也, 西岡典子, 安田耕一, 藤間憲幸, 鬼丸力也, 清水伸一, 白土博樹
日本医学放射線学会総会抄録集, 67th, S193, 28 Feb. 2008
Japanese

Histopathologic consideration of fiducial gold markers inserted for real-time tumor-tracking radiotherapy against lung cancer
Mikado Imura, Koichi Yamazaki, Kanako C. Kubota, Tomoo Itoh, Rikiya Onimaru, Yasushi Cho, Yasuhiro Hida, Kichizo Kaga, Yuya Onodera, Shigeaki Ogura, Hirotoshi Dosaka-Akita, Hiroki Shirato, Masaharu Nishimura
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 70, 2, 382, 384, Feb. 2008, [Peer-reviewed]
English, Scientific journal

Steep dose-response relationship for stage I non-small-cell lung cancer using hypofractionated high-dose irradiation by real-time tumor-tracking radiotherapy
Rikiya Onimaru, Masaharu Fujino, Koichi Yamazaki, Yuya Onodera, Hiroshi Taguchi, Norio Katoh, Fumihiro Hommura, Satoshi Oizumi, Masaharu Nishimura, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 70, 2, 374, 381, Feb. 2008, [Peer-reviewed]
English, Scientific journal

Transcatheter arterial embolization with absolute ethanol injection for enlarged polycystic kidneys after failed metallic coil embolization
Yusuke Sakuhara, Fumi Kato, Daisuke Abo, Yu Hasegawa, Tadashi Shimizu, Satoshi Terae, Hiroki Shirato
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 19, 2, 267, 271, Feb. 2008, [Peer-reviewed]
English, Scientific journal

CT during arteriographyによる膵の血流分布領域の検討　　　　　　　　　　　　　　　
作原 祐介, 児玉 芳尚, 阿保 大介, 長谷川 悠, 清水 匡, 白土 博樹
日本医学放射線学会学術集会抄録集, 67回, S361, S361, (公社)日本医学放射線学会, Feb. 2008
Japanese

Exhale fluctuation in respiratory-gated radiotherapy of the lung: A pitfall of respiratory gating shown in a synchronized internal/external marker recording study
Seiko Nishioka, Takeshi Nishioka, Masaki Kawahara, Shigeru Tanaka, Tadao Hiromura, Kazuo Tomita, Hiroki Shirato
RADIOTHERAPY AND ONCOLOGY, 86, 1, 69, 76, Jan. 2008, [Peer-reviewed]
English, Scientific journal

PP-126 ハイリスク前立腺癌に対する動体追跡放射線療法(前立腺腫瘍/放射線治療2,一般演題ポスター,第96回日本泌尿器科学会総会)
三浦 克紀, 篠原 信雄, 大坂 康博, 土屋 邦彦, 安部 崇重, 佐澤 陽, 原林 透, 白土 博樹, 野々村 克也
日本泌尿器科学会雑誌, 99, 2, 409, 409, 一般社団法人 日本泌尿器科学会, 2008
Japanese

Correlation identification between internal/external motion signals
Huanmei Wu, Qingya Zhao, Ross Berbeco, Seiko Nishioka, Hiroki Shirato, Steve B. Jiang
MEDICAL IMAGING 2008: PHYSICS OF MEDICAL IMAGING, PTS 1-3, 6913, 2008, [Peer-reviewed]
English, International conference proceedings

Outcome of stereotactic body radiotherapy for small lung lesions highly suggestive of primary non-small cell lung cancer on clinical/radiological examination
Inoue T, Shimizu S, Takeda A, Onishi H, Nagata Y, Kimura T, Karasawa K, Arimoto T, Hareyama M, Shirato H
International Journal of Radiation Oncology Biology Physics, 72, 1, S432, 2008, [Peer-reviewed]

Correlation between parameters describing tumour motion and its location in the lungs
Huanmei Wu, George Sandison, Li Zhao, Qingya Zhao, Hiroki Shirato, Steve Jiang
AUSTRALASIAN PHYSICAL & ENGINEERING SCIENCES IN MEDICINE, 30, 4, 341, 344, Dec. 2007, [Peer-reviewed]
English, Scientific journal

Combination tumor immunotherapy with radiotherapy and Th1 cell therapy against murine lung carcinoma
Hiroshi Yokouchi, Kenji Chamoto, Daiko Wakita, Koichi Yamazaki, Hiroki Shirato, Tsuguhide Takeshima, Hirotoshi Dosaka-Akita, Masaharu Nishimura, Zhang Yue, Hidemitsu Kitamura, Takashi Nishimura
CLINICAL & EXPERIMENTAL METASTASIS, 24, 7, 533, 540, Nov. 2007, [Peer-reviewed]
English, Scientific journal

Influence of surgical staples on Radiofrequency ablation using multitined expandable electrodes
Yusuke Sakuhara, Tadashi Shimizu, Daisuke Abo, Yu Hasegawa, Fumi Kato, Yoshihisa Kodama, Hiroki Shirato
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 30, 6, 1201, 1205, Nov. 2007, [Peer-reviewed]
English, Scientific journal

Adaptive prediction of respiratory motion for motion compensation radiotherapy
Qing Ren, Seiko Nishioka, Hiroki Shirato, Ross I. Berbeco
PHYSICS IN MEDICINE AND BIOLOGY, 52, 22, 6651, 6661, Nov. 2007, [Peer-reviewed]
English, Scientific journal

64列および4列のCT angiographyでの肝移植ドナーにおける肝動脈描出能の比較検討
藤間 憲幸, 小野寺 祐也, 白土 博樹
核医学, 44, 4, 389, 390, (一社)日本核医学会, Nov. 2007
Japanese

HHTに合併した中枢神経AVFの検討
笹森徹, 中山若樹, 黒田敏, 飛騨一利, 岩崎喜信, 浅野剛, 吉田大介, 白土博樹
J Neuroendovascular Ther, 1, 2, 257, 01 Nov. 2007
Japanese

Intercepting radiotherapy using a real-time tumor-tracking radiotherapy system for highly selected patients with hepatocellular carcinoma unresectable with other modalities
Hiroshi Taguchi, Yusuke Sakuhara, Shuhei Hige, Kei Kitamura, Yasuhiro Osaka, Daisuke Abo, Daichi Uchida, Akihiro Sawada, Toshiya Kamiyama, Tadashi Shimizu, Hiroki Shirato, Kazuo Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69, 2, 376, 380, Oct. 2007, [Peer-reviewed]
English, Scientific journal

Efficacy of preoperative radiotherapy to portal vein tumor thrombus in the main trunk or first branch in patients with hepatocellular carcinoma
Toshiya Kamiyama, Kazuaki Nakanishi, Hideki Yokoo, Munenori Tahara, Takahito Nakagawa, Hirofumi Kamachi, Hiroshi Taguchi, Hiroki Shirato, Michiaki Matsushita, Satoru Todo
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 12, 5, 363, 368, Oct. 2007, [Peer-reviewed]
English, Scientific journal

Matrixmetalloproteinases: Up-regulated in subclones that survived 10-Gy irradiation
Takeshi Nishioka, Motoaki Yasuda, Kaori Tsutsumi, Hisashi Haga, Hiroki Shirato
Radiation Medicine - Medical Imaging and Radiation Oncology, 25, 8, 430, 431, 8, Oct. 2007, [Peer-reviewed]
English

Internal-external correlation investigations of respiratory induced motion of lung tumors
Dan Ionascu, Steve B. Jiang, Seiko Nishioka, Hiroki Shirato, Ross I. Berbeco
MEDICAL PHYSICS, 34, 10, 3893, 3903, Oct. 2007, [Peer-reviewed]
English, Scientific journal

The management of imaging dose during image-guided radiotherapy: Report of the AAPM Task Group 75
Martin J. Murphy, James Balter, Stephen Balter, Jose A. BenComo, Indra J. Das, Steve B. Jiang, C.-M. Ma, Gustavo H. Olivera, Raymond F. Rodebaugh, Kenneth J. Ruchala, Hiroki Shirato, Fang-Fang Yin
MEDICAL PHYSICS, 34, 10, 4041, 4063, Oct. 2007, [Peer-reviewed]
English

Polycystic kidney diseaseに対するエタノールによる動脈塞栓術の経験　　　　　　　　　　　　　　　
作原 祐介, 阿保 大介, 長谷川 悠, 藤間 憲幸, 白土 博樹, 清水 匡
IVR: Interventional Radiology, 22, 4, 503, 503, (一社)日本インターベンショナルラジオロジー学会, Oct. 2007
Japanese

Enlarged polycystic liverに対する動脈塞栓術の経験　　　　　　　　　　　　　　　
藤間 憲幸, 長谷川 悠, 作原 祐介, 阿保 大介, 白土 博樹, 清水 匡, 嶋村 剛
IVR: Interventional Radiology, 22, 4, 503, 503, (一社)日本インターベンショナルラジオロジー学会, Oct. 2007
Japanese

肝移植術時に作成された門脈下大静脈短絡路(PCシャント)をcoil塞栓できた1例　　　　　　　　　　　　　　　
阿保 大介, 作原 祐介, 長谷川 悠, 藤間 憲幸, 白土 博樹, 清水 匡, 嶋村 剛, 古川 博之
IVR: Interventional Radiology, 22, 4, 503, 503, (一社)日本インターベンショナルラジオロジー学会, Oct. 2007
Japanese

肝移植後膵液瘻による合併症に対しIVRにて複合的に対処した1例　　　　　　　　　　　　　　　
長谷川 悠, 阿保 大介, 作原 祐介, 藤間 憲幸, 白土 博樹, 清水 匡, 嶋村 剛, 古川 博之
IVR: Interventional Radiology, 22, 4, 505, 505, (一社)日本インターベンショナルラジオロジー学会, Oct. 2007
Japanese

胆嚢・胆管癌・膵癌根治術後出血に対し動脈塞栓術を施行した症例の検討　　　　　　　　　　　　　　　
阿保 大介, 作原 祐介, 長谷川 悠, 藤間 憲幸, 白土 博樹, 清水 匡
IVR: Interventional Radiology, 22, 4, 505, 505, (一社)日本インターベンショナルラジオロジー学会, Oct. 2007
Japanese

頭頸部癌に対する超選択的抗癌剤動注化学療法　　　　　　　　　　　　　　　
吉田 大介, 浅野 剛, 白土 博樹, 本間 明宏, 鈴木 章之, 福田 諭
IVR: Interventional Radiology, 22, 4, 502, 502, (一社)日本インターベンショナルラジオロジー学会, Oct. 2007
Japanese

Statistical analysis and correlation discovery of tumor respiratory motion
Huanmei Wu, Gregory C. Sharp, Qingya Zhao, Hiroki Shirato, Steve B. Jiang
PHYSICS IN MEDICINE AND BIOLOGY, 52, 16, 4761, 4774, Aug. 2007, [Peer-reviewed]
English, Scientific journal

Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone
Hidefumi Aoyama, Masao Tago, Norio Kato, Tatsuya Toyoda, Masahiro Kenjyo, Saeko Hirota, Hiroki Shioura, Taisuke Inomata, Etsuo Kunieda, Kazushige Hayakawa, Keiichi Nakagawa, Gen Kobashi, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 68, 5, 1388, 1395, Aug. 2007, [Peer-reviewed]
English, Scientific journal

Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: Updated results of 257 patients in a Japanese multi-institutional study
Hiroshi Onishi, Hiroki Shirato, Yasushi Nagata, Masahiro Hiraoka, Masaharu Fujino, Kotaro Gomi, Yuzuru Niibe, Katsuyuki Karasawa, Kazushige Hayakawa, Yoshihiro Takai, Tomoki Kimura, Atsuya Takeda, Atsushi Ouchi, Masato Hareyama, Masaki Kokubo, Ryusuke Hara, Jun Itami, Kazunari Yamada, Tsutomu Araki
JOURNAL OF THORACIC ONCOLOGY, 2, 7, S94, S100, Jul. 2007, [Peer-reviewed]
English, Scientific journal

Accuracy of tumor motion compensation algorithm from a robotic respiratory tracking system: A simulation study
Yvette Seppenwoolde, Ross I. Berbeco, Seiko Nishioka, Hiroki Shirato, Ben Heijmen
MEDICAL PHYSICS, 34, 7, 2774, 2784, Jul. 2007, [Peer-reviewed]
English, Scientific journal

Experience of high-dose-rate brachytherapy for head and neck cancer treated by a customized intraoral mold technique
Kenichi Obinata, Keiichi Ohmori, Hiroki Shirato, Motoyasu Nakamura
Radiation Medicine - Medical Imaging and Radiation Oncology, 25, 4, 181, 186, 4, May 2007, [Peer-reviewed]
English, Scientific journal

腎・副腎腫瘍に対する動体追跡照射;臨床的検討について
芹澤慈子, 加藤徳雄, 白土博樹, 鬼丸力也, 大坂康博, 鈴木恵士郎, 渡辺明, 澤田明徳, 清水匡, 宮坂和男, 清水伸一
Radiat Med, 25, 18, 25 Apr. 2007
Japanese

腎・副腎腫瘍に対する動体追跡照射;技術的検討について
加藤徳雄, 芹澤慈子, 白土博樹, 鬼丸力也, 大坂康博, 鈴木恵士郎, 渡辺佳明, 阿保大介, 清水匡, 宮坂和男, 清水伸一
Radiat Med, 25, 17, 25 Apr. 2007
Japanese

頭頚部癌のDOC併用放射線療法;副作用軽減を目的としたステロイド使用について
小野寺俊輔, 木下留美子, 藤野賢治, 加藤徳雄, 田口大志, 鬼丸力也, 大阪康博, 清水伸一, 鈴木恵士郎, 西岡健, 白土博樹
Radiat Med, 25, 15, 25 Apr. 2007
Japanese

動体追跡装置を用いた照射中の乳腺表面の動きの検討
木下留美子, 清水伸一, 加藤徳雄, 藤野賢治, 鬼丸力也, 白土博樹
日本医学放射線学会学術集会抄録集, 66th, S212, 28 Feb. 2007
Japanese

Organ motion in image-guided radiotherapy: lessons from real-time tumor-tracking radiotherapy
Hiroki Shirato, Shinichi Shimizu, Kei Kitamura, Rikiya Onimaru
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 12, 1, 8, 16, Feb. 2007, [Peer-reviewed]
English

当院における乳幼児生体肝移植後の門脈狭窄に対するPTA症例の検討　　　　　　　　　　　　　　　
作原 祐介, 阿保 大介, 長谷川 悠, 児玉 芳尚, 清水 匡, 白土 博樹
日本医学放射線学会学術集会抄録集, 66回, S316, S317, (公社)日本医学放射線学会, Feb. 2007
Japanese

喉頭癌に対する化学放射線同時併用療法後salvage手術の合併症　　　　　　　　　　　　　　　
古田康, 本間明宏, 折舘伸彦, 鈴木章之, 畠山博充, 瀧重成, 坂下智博, 西岡健, 鈴木恵士郎, 白土博樹, 関堂充, 山本有平, 福田
頭頸部癌, 33, 356-360, Jan. 2007, [Peer-reviewed]
Japanese, Scientific journal

A novel approach to advanced carcinoma of the tongue: Cases successfully treated with combination of superselective intra-arterial chemotherapy and external/high-dose-rate interstitial radiotherapy
Takeshi Nishioka, Akihiro Homma, Yasushi Furuta, Hidefumi Aoyama, Fumiyuki Suzuki, Keiichi Ohmori, Takeshi Asano, Daisuke Yoshida, Hiroki Shirato, Satoshi Fukuda
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 36, 12, 822, 826, Dec. 2006, [Peer-reviewed]
English, Scientific journal

"Watch-and-see" policy for the clinically positive neck in head and neck cancer treated with chemoradiotherapy
Akihiro Homma, Yasushi Furuta, Nobuhiko Oridate, Fumiyuki Suzuki, Eisaku Higuchi, Takeshi Nishioka, Hiroki Shirato, Tatsumi Nagahashi, Katsunori Yagi, Satoshi Fukuda
International Journal of Clinical Oncology, 11, 6, 441, 448, 6, Dec. 2006, [Peer-reviewed]
English, Scientific journal

Dosimetric verification in participating institutions in a stereotactic body radiotherapy trial for stage I non-small cell lung cancer: Japan clinical oncology group trial (JCOG0403)
Teiji Nishio, Etsuo Kunieda, Hiroki Shirato, Satoshi Ishikura, Hiroshi Onishi, Kunihiko Tateoka, Masahiro Hiraoka, Yuichirou Narita, Masataka Ikeda, Tomonori Goka
PHYSICS IN MEDICINE AND BIOLOGY, 51, 21, 5409, 5417, Nov. 2006, [Peer-reviewed]
English, Scientific journal

Residual motion of lung tumors in end-of-inhale respiratory gated radiotherapy based on external surrogates
Ross I. Berbeco, Seiko Nishioka, Hiroki Shirato, Steve B. Jiang
MEDICAL PHYSICS, 33, 11, 4149, 4156, Nov. 2006, [Peer-reviewed]
English, Scientific journal

副腎領域における腹臥位と仰臥位でのマーカー移動と迎撃照射の有効性の検討
加藤徳雄, 白土博樹, 鬼丸力也, 大坂康博, 清水伸一, 阿保大介, 作原祐介, 宮坂和男
日本放射線腫よう学会誌, 18, Supplement 1, 152, 25 Oct. 2006
Japanese

鼻副鼻腔癌に対する超選択的動注療法+照射の同時併用療法
本間 明宏, 古田 康, 鈴木 章之, 浅野 剛, 吉田 大介, 西岡 健, 鈴木 恵士郎, 白土 博樹, 福田 諭
耳鼻と臨床, 52, Suppl.3, S213, S219, 耳鼻と臨床会, Sep. 2006
Japanese

頭頸部癌におけるchemoradiationの有用性と限界 超選択的動注によるchemoradiationの有用性と限界　　　　　　　　　　　　　　　
本間 明宏, 古田 康, 鈴木 章之, 古沢 純, 折舘 伸彦, 浅野 剛, 吉田 大介, 西岡 健, 鈴木 恵士郎, 白土 博樹, 福田 諭
日本癌治療学会誌, 41, 2, 323, 323, (一社)日本癌治療学会, Sep. 2006
Japanese

Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases - A randomized controlled trial
H Aoyama, H Shirato, M Tago, K Nakagawa, T Toyoda, K Hatano, M Kenjyo, N Oya, S Hirota, H Shioura, E Kunieda, T Inomata, K Hayakawa, N Katoh, G Kobashi
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 295, 21, 2483, 2491, Jun. 2006, [Peer-reviewed]
English, Scientific journal

Hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumor
N Katoh, H Shirato, H Aoyama, R Onimaru, K Suzuki, K Hida, K Miyasaka, Y Iwasaki
JOURNAL OF NEURO-ONCOLOGY, 78, 1, 63, 69, May 2006, [Peer-reviewed]
English, Scientific journal

超選択的動注療法+照射の同時併用療法のリンパ節転移への効果　　　　　　　　　　　　　　　
本間 明宏, 古田 康, 鈴木 章之, 浅野 剛, 古沢 純, 折舘 伸彦, 樋口 栄作, 永橋 立望, 鈴木 恵士郎, 西岡 健, 白土 博樹, 福田 諭
頭頸部癌, 32, 2, 177, 177, (一社)日本頭頸部癌学会, May 2006
Japanese

Uncertainty in treatment of head-and-neck tumors by use of intraoral mouthpiece and embedded fiducials
M Oita, K Ohmori, K Obinata, R Kinoshita, R Onimaru, K Tsuchiya, K Suzuki, T Nishioka, H Ohsaka, K Fujita, T Shimamura, H Shirato, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 64, 5, 1581, 1588, Apr. 2006, [Peer-reviewed]
English, Scientific journal

Spinal cord gliomas: A multi-institutional retrospective analysis
M Abdel-Wahab, B Etuk, J Palermo, H Shirato, J Kresl, O Yapicier, G Walker, BW Scheithauer, E Shaw, C Lee, W Curran, T Thomas, A Markoe
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 64, 4, 1060, 1071, Mar. 2006, [Peer-reviewed]
English, Scientific journal

Speed and amplitude of lung tumor motion precisely detected in four-dimensional setup and in real-time tumor-tracking radiotherapy
H Shirato, K Suzuki, GC Sharp, K Fujita, R Onimaru, M Fujino, N Kato, Y Osaka, R Kinoshita, H Taguchi, S Onodera, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 64, 4, 1229, 1236, Mar. 2006, [Peer-reviewed]
English, Scientific journal

副腎領域における動体追跡放射線治療
加藤徳雄, 白土博樹, 鬼丸力也, 清水伸一, 大坂康博, 阿保大介, 作原祐介, 沢田明宏, 清水匡, 宮坂和男
日本医学放射線学会学術集会抄録集, 65th, S214, 25 Feb. 2006
Japanese

Characteristics of patients who developed radiation pneumonitis requiring steroid therapy after stereotactic irradiation for lung tumors
M Fujino, H Shirato, H Onishi, H Kawamura, K Takayama, M Koto, R Onimaru, Y Nagata, M Hiraoka
CANCER JOURNAL, 12, 1, 41, 46, Jan. 2006, [Peer-reviewed]
English, Scientific journal

CS3-6 局所浸潤性膀胱癌に対するネダプラチン併用動体追跡放射線療法(総合企画3「浸潤性膀胱癌に対する膀胱温存治療」,第94回日本泌尿器科学会総会)
白土 博樹, 大坂 康博, 宮坂 和男, 佐澤 陽, 原林 透, 篠原 信雄, 野々村 克也
日本泌尿器科学会雑誌, 97, 2, 116, 116, 一般社団法人 日本泌尿器科学会, 2006
Japanese

Real-time and precise monitoring of the breast motion during irradiation using real-time tumor-tracking radiotherapy (RTRT) system
Kinoshita R, Shimizu S, Katoh N, Onimaru R, Shirato H, Miyasaka
International Journal of Radiation Oncology Biology Physics, 66, 3, S608, 2006, [Peer-reviewed]

Can FDG-PET detect subclinical lymph node metastatis of esophageal cancer and contribute to the radiation treatment planning? Compared with images and pathological findings
Shimizu S, Hosokawa M, Itoh K, Takahashi H, Fujita M, Shirato H
International Journal of Radiation Oncology Biology Physics, 66, 3, S279, 2006, [Peer-reviewed]

Insertion and fixation of fiducial markers for setup and tracking of lung tumors in radiotherapy
M Imura, K Yamazaki, H Shirato, R Onimaru, M Fujino, S Shimizu, T Harada, S Ogura, H Dosaka-Akita, K Miyasaka, M Nishimura
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 63, 5, 1442, 1447, Dec. 2005, [Peer-reviewed]
English, Scientific journal

放射線治療効果の向上を目指した新手法開発とその臨床応用 動体追跡照射装置を用いた放射線治療
鬼丸 力也, 白土 博樹, 藤野 賢治, 田口 大志, 加藤 徳雄, 大坂 康博, 清水 伸一, 青山 英史, 鈴木 恵士郎
日本放射線影響学会大会講演要旨集, 48回, 75, 75, (一社)日本放射線影響学会, Nov. 2005
English

当科における頭頸部高線量率放射線治療　　　　　　　　　　　　　　　
大森 桂一, 西岡 健, 土屋 和彦, 青山 英史, 木下 留美, 西岡 井子, 鈴木 恵士郎, 白土 博樹
日本放射線腫瘍学会誌, 17, Suppl.1, 126, 126, (公社)日本放射線腫瘍学会, Oct. 2005
Japanese

The effect of tumor location and respiratory function on tumor movement estimated by real-time tracking radiotherapy (RTRT) system
R Onimaru, H Shirato, M Fujino, K Suzuki, K Yamazaki, M Nishimura, H Dosaka-Akita, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 63, 1, 164, 169, Sep. 2005, [Peer-reviewed]
English, Scientific journal

[Stereotactic irradiation (Linac) for brain tumors].
Shirato H, Aoyama H, Suzuki K, Miyasaka K
Nihon rinsho. Japanese journal of clinical medicine, 63 Suppl 9, 419, 424, Sep. 2005, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal

【脳腫瘍の診断と治療 最新の研究動向】脳腫瘍の治療 放射線療法 定位放射線照射療法(リニアック)
白土 博樹, 青山 英史, 鈴木 恵士郎, 宮坂 和男
日本臨床, 63, 増刊9 脳腫瘍の診断と治療, 419, 424, (株)日本臨床社, Sep. 2005
Japanese

口腔癌の最新治療 舌癌に対する超選択的動注療法と高線量率組織内照射の併用療法　　　　　　　　　　　　　　　
本間 明宏, 古田 康, 鈴木 章之, 浅野 剛, 吉田 大介, 西岡 健, 鈴木 恵士郎, 白土 博樹, 福田 諭
日本癌治療学会誌, 40, 2, 236, 236, (一社)日本癌治療学会, Sep. 2005
Japanese

Residual motion of lung tumours in gated radiotherapy with external respiratory surrogates
RI Berbeco, S Nishioka, H Shirato, GTY Chen, SB Jiang
PHYSICS IN MEDICINE AND BIOLOGY, 50, 16, 3655, 3667, Aug. 2005, [Peer-reviewed]
English, Scientific journal

聴神経腫瘍に対する定位分割照射の治療成績　　　　　　　　　　　　　　　
坂本 徹, 白土 博樹, 澤村 豊, 鈴木 恵士郎, 青山 英史, 加藤 徳雄
定位的放射線治療, 9, 37, 44, 日本定位放射線治療学会, Aug. 2005
Japanese

Comparison of imaging modalities for the accurate delineation of arteriovenous malformation, with reference to stereotactic radiosurgery
H Aoyama, H Shirato, N Katoh, K Kudo, T Asano, S Kuroda, T Ishikawa, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 62, 4, 1232, 1238, Jul. 2005, [Peer-reviewed]
English, Scientific journal

北海道大学病院における超選択的動注療法+放射線の同時併用療法の治療成績　　　　　　　　　　　　　　　
本間 明宏, 古田 康, 鈴木 章之, 浅野 剛, 永橋 立望, 折舘 伸彦, 古沢 純, 畠山 博充, 鈴木 恵士郎, 西岡 健, 白土 博樹, 福田 諭
頭頸部癌, 31, 2, 242, 242, (一社)日本頭頸部癌学会, May 2005
Japanese

ドセタキセル・放射線同時併用療法におけるp53過剰発現と392セリン残基リン酸化の予後因子としての検討　　　　　　　　　　　　　　　
樋口 榮作, 折舘 伸彦, 本間 明宏, 永橋 立望, 古田 康, 鈴木 章之, 西岡 健, 鈴木 恵士郎, 滝沢 昌彦, 白土 博樹, 福田 諭
頭頸部癌, 31, 2, 227, 227, (一社)日本頭頸部癌学会, May 2005
Japanese

化学放射線同時併用療法後の喉頭全摘術における合併症の検討　　　　　　　　　　　　　　　
古田 康, 本間 明宏, 折舘 伸彦, 樋口 栄作, 鈴木 章之, 西岡 健, 青山 英史, 鈴木 恵士郎, 白土 博樹, 福田 諭
頭頸部癌, 31, 2, 220, 220, (一社)日本頭頸部癌学会, May 2005
Japanese

[Highly quality-controlled radiation therapy].
Shirato H
Gan to kagaku ryoho. Cancer & chemotherapy, 32, 448, 452, 4, Apr. 2005, [Peer-reviewed]

Long-term results of ethmoid squamous cell or undifferentiated carcinoma treated with radiotherapy with or without surgery
D Uchida, H Shirato, R Onimaru, H Endou, H Aoyama, K Tsuchiya, T Nishioka, A Homma, Y Furuta, S Fukuda, K Miyasaka
CANCER JOURNAL, 11, 2, 152, 156, Mar. 2005, [Peer-reviewed]
English, Scientific journal

頭頸部腫瘍における放射線治療前FDG-PETの検討 SUVの意義について　　　　　　　　　　　　　　　
鈴木 恵士郎, 西岡 健, 青山 英史, 土屋 和彦, 白土 博樹, 宮坂 和男, 加藤 千恵次, 志賀 哲, 中駄 邦博, 玉木 長良
日本医学放射線学会学術集会抄録集, 64回, S298, S299, (公社)日本医学放射線学会, Feb. 2005
Japanese

Rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for advanced head and neck cancer
A Homma, Y Furuta, F Suzuki, N Oridate, H Hatakeyama, T Nagahashi, S Ushikoshi, T Asano, T Nishioka, H Shirato, S Fukuda
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 27, 1, 65, 71, Jan. 2005, [Peer-reviewed]
English, Scientific journal

Tracking errors in a prototype real-time tumour tracking system
GC Sharp, SB Jiang, S Shimizu, H Shirato
PHYSICS IN MEDICINE AND BIOLOGY, 49, 23, 5347, 5356, Dec. 2004, [Peer-reviewed]
English, Scientific journal

A finite state model for respiratory motion analysis in image guided radiation therapy
HM Wu, GC Sharp, B Salzberg, D Kaeli, H Shirato, SB Jiang
PHYSICS IN MEDICINE AND BIOLOGY, 49, 23, 5357, 5372, Dec. 2004, [Peer-reviewed]
English, Scientific journal

Pilot study of modified version of CHOP plus radiotherapy for early-stage aggressive non-Hodgkin's lymphoma of the head and neck
T Nishioka, K Tsuchiya, S Nishioka, T Kitahara, K Ohmori, A Homma, H Aoyma, M Shindoh, H Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 60, 3, 847, 852, Nov. 2004, [Peer-reviewed]
English, Scientific journal

Stereotactic irradiation for intracranial arteriovenous malformation using stereotactic radiosurgery or hypofractionated stereotactic radiotherapy
TC Chang, H Shirato, H Aoyama, S Ushikoshi, N Kato, S Kuroda, T Ishikawa, K Houkin, Y Iwasaki, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 60, 3, 861, 870, Nov. 2004, [Peer-reviewed]
English, Scientific journal

High dose three-dimensional conformal boost (3DCB) using an orthogonal diagnostic X-ray set-up for patients with gynecological malignancy: a new application of real-time tumor-tracking system
R Yamamoto, A Yonesaka, S Nishioka, H Watari, T Hashimoto, D Uchida, H Taguchi, T Nishioka, B Miyasaka, N Sakuragi, H Shirato
RADIOTHERAPY AND ONCOLOGY, 73, 2, 219, 222, Nov. 2004, [Peer-reviewed]
English, Scientific journal

画像診断技術の進歩と放射線治療 脳動静脈奇形の定位照射を例として　　　　　　　　　　　　　　　
青山 英史, 加藤 徳雄, 土屋 和彦, 藤野 賢治, 白土 博樹, 宮坂 和男
日本医学放射線学会雑誌, 64, 8, 577, 577, (公社)日本医学放射線学会, Nov. 2004
Japanese

Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma - Clinical outcomes in 245 subjects in a Japanese multinstitutional study
H Onishi, T Araki, H Shirato, Y Nagata, M Hiraoka, K Gomi, T Yamashita, Y Niibe, K Karasawa, K Hayakawa, Y Takai, T Kimura, Y Hirokawa, A Takeda, A Ouchi, M Hareyama, M Kokubo, R Hara, J Itami, K Yamada
CANCER, 101, 7, 1623, 1631, Oct. 2004, [Peer-reviewed]
English, Scientific journal

Three-dimensional conformal setup (3D-CSU) of patients using the coordinate system provided by three internal fiducial markers and two orthogonal diagnostic X-ray systems in the treatment room
H Shirato, M Oita, K Fujita, S Shimizu, R Onimaru, S Uegaki, Y Watanabe, N Kato, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 60, 2, 607, 612, Oct. 2004, [Peer-reviewed]
English, Scientific journal

肺癌放射線治療におけるFDG-PETでの標的体積の抽出法の観察者間差　　　　　　　　　　　　　　　
藤野 賢治, 加藤 徳雄, 白土 博樹, 青山 英史, 渡辺 良晴, 熊谷 まなみ, 西岡 健, 宮坂 和男
日本放射線腫瘍学会誌, 16, Suppl.1, 108, 108, (公社)日本放射線腫瘍学会, Oct. 2004
Japanese

Impact of margin for target volume in low-dose involved field radiotherapy after induction chemotherapy for intracranial germinoma
H Shirato, H Aoyama, J Ikeda, K Fujieda, N Kato, N Ishi, K Miyasaka, Y Iwasaki, Y Sawamura
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 60, 1, 214, 217, Sep. 2004, [Peer-reviewed]
English, Scientific journal

Feasibility of synchronization of real-time tumor-tracking radiotherapy and intensity-modulated radiotherapy from viewpoint of excessive dose from fluoroscopy
H Shirato, M Oita, K Fujita, Y Watanabe, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 60, 1, 335, 341, Sep. 2004, [Peer-reviewed]
English, Scientific journal

Randomized phase II trial of concomitant chemoradiotherapy using weekly carboplatin or daily low-dose cisplatin for squamous cell carcinoma of the head and neck
A Homma, H Shirato, Y Furuta, T Nishioka, N Oridate, K Tsuchiya, T Nagahashi, H Aoyama, Y Inuyama, S Fukuda
CANCER JOURNAL, 10, 5, 326, 332, Sep. 2004, [Peer-reviewed]
English, Scientific journal

頭頸部癌治療における最近の進歩と今後の臨床展開 治療の個別化に向けて 鼻副鼻腔進行癌に対する超選択的動注療法+放射線同時併用療法　　　　　　　　　　　　　　　
本間 明宏, 古田 康, 永橋 立望, 白土 博樹, 福田 諭
日本癌治療学会誌, 39, 2, 271, 271, (一社)日本癌治療学会, Sep. 2004
Japanese

放射線治療に期待されるもの 4次元放射線治療
白土博樹, 鬼丸力也, 清水伸一, 宮坂和男
日本癌学会総会記事, 63rd, 416, 25 Aug. 2004
Japanese

Application of real-time tumor-tracking and gated radiotherapy system for unresectable pancreatic cancer
YC Ahn, S Shimizuz, H Shirato, T Hashimoto, Y Osaka, XQ Zhang, T Abe, M Hosokawa, K Miyasaka
YONSEI MEDICAL JOURNAL, 45, 4, 584, 590, Aug. 2004, [Peer-reviewed]
English, Scientific journal

化学療法併用放射線療法後に喉頭全摘術後の瘻孔発生率は高まるか? 過去10年間の喉頭全摘症例の検討　　　　　　　　　　　　　　　
古田 康, 本間 明宏, 永橋 立望, 樋口 栄作, 鈴木 章之, 折舘 伸彦, 福田 諭, 西岡 健, 青山 英史, 白土 博樹
頭頸部腫瘍, 30, 2, 270, 270, (一社)日本頭頸部癌学会, May 2004
Japanese

頬粘膜腫瘍の放射線治療成績　　　　　　　　　　　　　　　
大森 桂一, 中村 博行, 山崎 裕, 小野 貢伸, 青山 英史, 土屋 和彦, 西岡 健, 白土 博樹, 本間 明宏, 古田 康, 中村 太保
頭頸部腫瘍, 30, 2, 195, 195, (一社)日本頭頸部癌学会, May 2004
Japanese

頭頸部癌に対するDocetaxelと放射線同時併用療法の有用性の検討　　　　　　　　　　　　　　　
樋口 榮作, 本間 明宏, 永橋 立望, 折舘 伸彦, 古田 康, 鈴木 章之, 西岡 健, 土屋 和彦, 青山 英史, 滝沢 昌彦, 白土 博樹, 福田 諭
頭頸部腫瘍, 30, 2, 194, 194, (一社)日本頭頸部癌学会, May 2004
Japanese

Integration of functional brain information into stereotactic irradiation treatment planning using magnetoencephalography and magnetic resonance axonography
H Aoyama, K Kamada, H Shirato, F Takeuchi, S Kuriki, Y Iwasaki, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 58, 4, 1177, 1183, Mar. 2004, [Peer-reviewed]
English, Scientific journal

肺腫ようの呼吸性移動距離に対する呼吸機能と腫よう存在部位による影響—動体追跡照射装置での検討—
鬼丸力也, 藤野賢治, 清水伸一, 白土博樹, 宮坂和男
日本医学放射線学会雑誌, 64, 2, S154, 25 Feb. 2004
Japanese

Prediction of respiratory tumour motion for real-time image-guided radiotherapy
GC Sharp, SB Jiang, S Shimizu, H Shirato
PHYSICS IN MEDICINE AND BIOLOGY, 49, 3, 425, 440, Feb. 2004, [Peer-reviewed]
English, Scientific journal

Intrafractional tumor motion: Lung and liver
H Shirato, Y Seppenwoolde, K Kitamura, R Onimura, S Shimizu
SEMINARS IN RADIATION ONCOLOGY, 14, 1, 10, 18, Jan. 2004, [Peer-reviewed]
English, Scientific journal

Integrated radiotherapy imaging system (IRIS): design considerations of tumour tracking with linac gantry-mounted diagnostic x-ray systems with flat-panel detectors
RI Berbeco, SB Jiang, GC Sharp, GTY Chen, H Mostafavi, H Shirato
PHYSICS IN MEDICINE AND BIOLOGY, 49, 2, 243, 255, Jan. 2004, [Peer-reviewed]
English, Scientific journal

Real-time monitoring of a digestive-tract marker to reduce adverse effects of moving organs at risk (OAR) in radiotherapy for thoracic and abdominal tumors
T Hashimoto, M Kato, H Shirato, S Shimizu, Y Ahn, N Kurauchi, T Morikawa, K Yamazaki, Y Akine, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 60, 1, S414, S414, 2004, [Peer-reviewed]
English

CP9-7 Real-time tumor-tracking radiotherapy(総合企画9「前立腺癌に対する新しい放射線治療」)
白土 博樹, 篠原 信雄, 原林 透, 喜多村 圭, 大坂 康博, 野々村 克也, 宮坂 和男
日本泌尿器科学会雑誌, 95, 2, 168, 168, 一般社団法人 日本泌尿器科学会, 2004
Japanese

Clinical significance of 3D reconstruction of arteriovenous malformation using digital subtraction angiography and its modification with CT information in stereotactic radiosurgery
XQ Zhang, H Shirato, H Aoyama, S Ushikoshi, T Nishioka, DZ Zhang, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 57, 5, 1392, 1399, Dec. 2003, [Peer-reviewed]
English, Scientific journal

定位放射線照射における投与線量の解釈 アンケート調査結果報告 JASTRO H13,H14年度研究課題報告
直居 豊, 赤松 将之, 伊藤 佳菜, 渡辺 太志, 笹井 啓資, 青山 英史, 白土 博樹, 永田 靖, 平岡 真寛, 藤川 章
日本放射線腫瘍学会誌, 15, 4, 297, 306, (公社)日本放射線腫瘍学会, Dec. 2003
Japanese

少量白金製剤併用放射線化学療法と超選択的動注療法
本間 明宏, 古田 康, 永橋 立望, 八木 克憲, 鈴木 章之, 牛越 聡, 浅野 剛, 白土 博樹, 西岡 健, 犬山 征夫, 福田 諭
耳鼻と臨床, 49, Suppl.3, S167, S174, 耳鼻と臨床会, Nov. 2003
Japanese

Management of vestibular schwannoma by fractionated stereotactic radiotherapy and associated cerebrospinal fluid malabsorption
Y Sawamura, H Shirato, T Sakamoto, H Aoyama, K Suzuki, R Onimaru, T Isu, S Fukuda, K Miyasaka
JOURNAL OF NEUROSURGERY, 99, 4, 685, 692, Oct. 2003, [Peer-reviewed]
English, Scientific journal

定位放射線照射における投与線量の解釈　　　　　　　　　　　　　　　
直居 豊, 伊藤 佳菜, 渡辺 太志, 笹井 啓資, 青山 英史, 白土 博樹, 永田 靖, 平岡 真寛, 藤川 章
日本放射線腫瘍学会誌, 15, Suppl.1, 68, 68, (公社)日本放射線腫瘍学会, Oct. 2003
Japanese

前立腺癌への動体追跡装置を用いた強度変調放射線治療75 Gy/30 fの初期経験　　　　　　　　　　　　　　　
大坂 康博, 喜多村 圭, 青山 英史, 土屋 和彦, 西岡 健, 白土 博樹, 宮坂 和男
日本放射線腫瘍学会誌, 15, Suppl.1, 86, 86, (公社)日本放射線腫瘍学会, Oct. 2003
Japanese

JROSG99-1第III相試験中間報告 1〜4個脳転移に対する定位単独と定位+全脳照射の比較　　　　　　　　　　　　　　　
青山 英史, 白土 博樹, 中川 恵一, 多湖 正夫
日本放射線腫瘍学会誌, 15, Suppl.1, 87, 87, (公社)日本放射線腫瘍学会, Oct. 2003
Japanese

金マーカー埋入義歯を用いた透視セットアップ照射　　　　　　　　　　　　　　　
大森 桂一, 土屋 和彦, 笈田 将皇, 渡辺 良晴, 青山 英史, 西岡 健, 白土 博樹
日本放射線腫瘍学会誌, 15, Suppl.1, 121, 121, (公社)日本放射線腫瘍学会, Oct. 2003
Japanese

長径2.5cm以上の聴神経鞘腫に対する定位放射線治療　　　　　　　　　　　　　　　
坂井 亙, 白土 博樹, 青山 英史, 坂本 徹, 宮坂 和男
日本放射線腫瘍学会誌, 15, Suppl.1, 148, 148, (公社)日本放射線腫瘍学会, Oct. 2003
Japanese

動体追跡システムを用いたIMRTの基礎的検討(1) 移動による線量分布への影響　　　　　　　　　　　　　　　
笈田 将皇, 渡辺 良晴, 白土 博樹, 青山 英史, 土屋 和彦, 清水 祐介, 藤田 勝久
日本放射線腫瘍学会誌, 15, Suppl.1, 154, 154, (公社)日本放射線腫瘍学会, Oct. 2003
Japanese

動体追跡システムを用いたIMRTの基礎的検討(2) 移動によるIMRTの線量分布への影響　　　　　　　　　　　　　　　
渡辺 良晴, 笈田 将皇, 白土 博樹, 青山 英史, 土屋 和彦, 清水 祐介, 藤田 勝久
日本放射線腫瘍学会誌, 15, Suppl.1, 155, 155, (公社)日本放射線腫瘍学会, Oct. 2003
Japanese

動体追跡照射における消化管,胸腹腔への金マーカー挿入術の開発　　　　　　　　　　　　　　　
橋本 孝之, 白土 博樹, 清水 伸一, 大坂 康博, 鬼丸 力也, 藤野 賢治, 宮坂 和男
日本放射線腫瘍学会誌, 15, Suppl.1, 77, 77, (公社)日本放射線腫瘍学会, Oct. 2003
Japanese

Effect of treatment time on outcome of radiotherapy for oral tongue carcinoma
Y Hosokawa, H Shirato, T Nishioka, K Tsuchiya, TC Chang, K Kagei, K Ohomori, K Obinata, M Kaneko, K Miyasaka, M Nakamura
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 57, 1, 71, 78, Sep. 2003, [Peer-reviewed]
English, Scientific journal

小児大脳PNET(primitive neuroectodermal tumor)に対するICE(IFX/CDDP/VP-16)化学療法を用いた集学的治療　　　　　　　　　　　　　　　
池田 潤, 小林 浩之, 石井 伸明, 澤村 豊, 岩崎 喜信, 青山 英史, 白土 博樹
日本癌治療学会誌, 38, 2, 510, 510, (一社)日本癌治療学会, Sep. 2003
Japanese

画像診断の進歩と放射線治療 治療計画と効果判定にどのように役立っているか 放射線脳壊死と腫瘍再発の鑑別におけるL-[methyl-11C]-methionine PET(Met-PET)
加藤 徳雄, 中駄 邦博, 青山 英史, 竹井 俊樹, 白土 博樹, 玉木 長良, 宮坂 和男
断層映像研究会雑誌, 30, 2〜3, 73, 73, 断層映像研究会, Sep. 2003
Japanese

頭頸部癌放射線・化学療法施行例における頸部リンパ節転移への対応　　　　　　　　　　　　　　　
本間 明宏, 古田 康, 永橋 立望, 白土 博樹, 西岡 健, 八木 克憲, 犬山 征夫, 福田 諭
日本癌治療学会誌, 38, 2, 352, 352, (一社)日本癌治療学会, Sep. 2003
Japanese

動体追跡照射データに対する関数データ解析法の適用
山谷 学, 島村 徹平, 小宮 由里子, 清水 伸一, 白土 博樹, 水田 正弘
日本統計学会講演報告集, 71, 0, 302, 303, 01 Sep. 2003
Japanese

Hypofractionated stereotactic radiotherapy alone without whole-brain irradiation for patients with solitary and oligo brain metastasis using noninvasive fixation of the skull
HI Aoyama, H Shirato, R Onimaru, K Kagei, J Ikeda, N Ishii, Y Sawamura, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 56, 3, 793, 800, Jul. 2003, [Peer-reviewed]
English, Scientific journal

Focal fractionated radiotherapy for intramedullary spinal arteriovenous malformations: 10-year experience
K Hida, H Shirato, T Isu, T Seki, R Onimaru, H Aoyama, S Ushikoshi, K Miyasaka, Y Iwasaki
JOURNAL OF NEUROSURGERY, 99, 1, 34, 38, Jul. 2003, [Peer-reviewed]
English, Scientific journal

Visualization of the corticospinal tract pathway using magnetic resonance axonography and magnetoencephalography for stereotactic irradiation planning of arteriovenous malformations
H Aoyama, K Kamada, H Shirato, F Takeuchi, S Kuriki, Y Iwasaki, K Miyasaka
RADIOTHERAPY AND ONCOLOGY, 68, 1, 27, 32, Jul. 2003, [Peer-reviewed]
English, Scientific journal

Reduction in acute morbidity using hypofractionated intensity-modulated radiation therapy assisted with a fluoroscopic real-time tumor-tracking system for prostate cancer: Preliminary results of a phase I/II study
K Kitamura, H Shirato, N Shinohara, T Harabayashi, R Onimaru, K Fujita, S Shimizu, K Nonomura, T Koyanagi, K Miyasaka
CANCER JOURNAL, 9, 4, 268, 276, Jul. 2003, [Peer-reviewed]
English, Scientific journal

【脊髄・脊椎腫瘍の治療戦略】脊髄・脊椎腫瘍への放射線治療戦略　　　　　　　　　　　　　　　
白土 博樹, 鬼丸 力也, 青山 英史, 宮坂 和男, 関 俊隆, 飛騨 一利, 岩崎 喜信
脊椎脊髄ジャーナル, 16, 6, 681, 687, (株)三輪書店, Jun. 2003
Japanese

Tolerance of organs at risk in small-volume, hypofractionated, image-guided radiotherapy for primary and metastatic lung cancers
R Onimaru, H Shirato, S Shimizu, K Kitamura, B Xu, S Fukumoto, TC Chang, K Fujita, M Oita, K Miyasaka, M Nishimura, H Dosaka-Akita
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 56, 1, 126, 135, May 2003, [Peer-reviewed]
English, Scientific journal

Tumor location, cirrhosis, and surgical history contribute to tumor movement in the liver, as measured during stereotactic irradiation using a real-time tumor-tracking radiotherapy system
K Kitamura, H Shirato, Y Seppenwoolde, T Shimizu, Y Kodama, H Endo, R Onimaru, M Oda, K Fujita, S Shimizu, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 56, 1, 221, 228, May 2003, [Peer-reviewed]
English, Scientific journal

Feasibility of insertion/implantation of 2.0-mm-diameter gold internal fiducial markers for precise setup and real-time tumor tracking in radiotherapy
H Shirato, T Harad, T Harabayashi, K Hida, H Endo, K Kitamura, R Onimaru, K Yamazaki, N Kurauchi, T Shimizu, N Shinohara, M Matsushita, H Dosaka-Akita, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 56, 1, 240, 247, May 2003, [Peer-reviewed]
English, Scientific journal

【脳腫瘍のキーワード】Linac surgery　　　　　　　　　　　　　　　
青山 英史, 白土 博樹
Clinical Neuroscience, 21, 5, 570, 571, (株)中外医学社, May 2003
Japanese

頭頸部がんに対する急速動注療法 頭頸部進行癌に対する超選択的動注療法と放射線の同時併用療法
本間 明宏, 古田 康, 牛越 聡, 鈴木 章之, 永橋 立望, 畠山 博充, 浅野 剛, 西岡 健, 白土 博樹, 福田 諭
頭頸部腫瘍, 29, 2, 265, 265, (一社)日本頭頸部癌学会, May 2003
Japanese

Synchronized moving aperture radiation therapy (SMART): average tumour trajectory for lung patients
T Neicu, H Shirato, Y Seppenwoolde, SB Jiang
PHYSICS IN MEDICINE AND BIOLOGY, 48, 5, 587, 598, Mar. 2003, [Peer-reviewed]
English, Scientific journal

肝腫ように対する動体追跡システムを用いた体幹部定位放射線治療の初期経験
大坂康博, 喜多村圭, 鬼丸力也, 清水伸一, 児玉芳尚, 清水匡, 白土博樹, 宮坂和男
日本医学放射線学会雑誌, 63, 2, S125, 25 Feb. 2003
Japanese

Clinical study of a spacer to help prevent osteoradionecrosis resulting from brachytherapy for tongue cancer
K Obinata, K Ohmori, K Tuchiya, T Nishioka, H Shirato, M Nakamura
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 95, 2, 246, 250, Feb. 2003, [Peer-reviewed]
English, Scientific journal

External beam radiation monotherapy for localized or locally advanced prostate cancer
A Takahashi, M Yanase, N Masumori, H Sasamura, T Oda, T Tanaka, N Itoh, T Tsukamoto, A Oouchi, M Hareyama, H Shirato, K Takatsuka, N Miyao
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 33, 2, 73, 77, Feb. 2003, [Peer-reviewed]
English, Scientific journal

放射線脳壊死と脳腫瘍の鑑別におけるL-[methyl-11C]-methionine PET(MET)　　　　　　　　　　　　　　　
加藤 徳雄, 中駄 邦博, 青山 英史, 竹井 俊樹, 白土 博樹, 玉木 長良, 宮坂 和男
日本医学放射線学会雑誌, 63, 2, S238, S238, (公社)日本医学放射線学会, Feb. 2003
Japanese

Is whole-brain irradiation necessary for primary central nervous system lymphoma? Patterns of recurrence after partial-brain irradiation
Y Shibamoto, N Hayabuchi, J Hiratsuka, S Tokumaru, H Shirato, M Sougawa, N Oya, Y Uematsu, M Hiraoka
CANCER, 97, 1, 128, 133, Jan. 2003, [Peer-reviewed]
English, Scientific journal

Effect of irradiation on enzymes of the capillary bed in rat ventricles
M Gao, H Shirato, K Miyasaka, T Koyama
OXYGEN TRANSPORT TO TISSUE XXIV, 530, 527, 533, 2003, [Peer-reviewed]
English, Scientific journal

頭部疾患の定位放射線照射と画像診断 良性腫瘍(聴神経鞘腫を中心に)　　　　　　　　　　　　　　　
青山 英史, 白土 博樹
臨床画像, 19, 1, 110, 115, (株)メジカルビュー社, Jan. 2003
Japanese

Long-term follow-up results with audiological assessment after fractionated stereotactic radiotherapy for vestibular schwannomas
Y Sawamura, H Shirato, T Sakamoto, H Aoyama, S Fukuda, K Miyasaka
ACOUSTIC NEUROMA, 10, 127, 128, 2003, [Peer-reviewed]
English, International conference proceedings

SUPERSELECTIVE ARTERIAL INFUSION AND CONCOMITANT RADIOTHERAPY FOR ADVANCED HEAD AND NECK CANCER
HOMMA Akihiro, FURUTA Yasushi, USHIKOSHI Satoshi, SUZUKI Fumiyuki, NAGAHASHI Tatsumi, HATAKEYAMA Hiromitsu, ASANO Takeshi, NISHIOKA Takeshi, SHIRATO Hiroki, FUKUDA Satoshi
Toukeibu Gan, 29, 3, 450, 456, Japan Society for Head and Neck Cancer, 2003
Japanese, Superselective arterial infusion for patients with advanced head and neck cancer has increasingly been applied in Japan. We analyzed our experiences and evaluated the efficacy and safety of this treatment. Patients and Methods: Forty-four patients, who were considered contraindicated for surgery or rejected radical surgery, received superselective intra-arterial infusion therapy of cisplatin (100-120mg/m²/week) with simultaneous intravenous infusion of thiosulfate to neutralize cisplatin toxicity, and conventional concomitant extrabeam radiotherapy (65Gy/26f/6.5weeks). Results: During the median follow-up period of 17 months, 2-year progression-free survival rate of primary lesion was 66.9%, and that of patients with T4b diseases 57%. The 2-year overall survival rate was 52.4%. Although acute toxic effects were considered acceptable, severe toxic events occurred in some cases, namely, cranial nerve palsy, MRSA pneumonia, sepsis, and osteoradionecrosis. Conclusions: We confirmed the high effectiveness of superselective arterial infusion and concomitant radiotherapy, which can concentrate the attack of decadose cisplatin on locoregional disease. Moreover, even patients with unresectable disease can be cured. We must clarify the treatment results and late side effects, and establish the indications for this treatment.

Calculation of rotational setup error using the real-time tracking radiation therapy (RTRT) system and its application to the treatment of spinal schwannoma
R Onimaru, H Shirato, H Aoyama, K Kitakura, T Seki, K Hida, K Fujita, K Kagei, T Nishioka, T Kunieda, Y Iwasaki, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 54, 3, 939, 947, Nov. 2002, [Peer-reviewed]
English, Scientific journal

Three-dimensional conformal radiotherapy for astrocytic tumors involving the eloquent area in children and young adults
T Nishihori, H Shirato, H Aoyama, R Onimaru, T Komae, N Ishii, J Ikeda, K Miyasaka, Y Sawamura, Y Iwasaki
JOURNAL OF NEURO-ONCOLOGY, 60, 2, 177, 183, Nov. 2002, [Peer-reviewed]
English, Scientific journal

【良性疾患の放射線治療】脳動静脈奇形　　　　　　　　　　　　　　　
張 大鎮, 青山 英史, 白土 博樹
臨床放射線, 47, 別冊, 84, 95, 金原出版(株), Nov. 2002
Japanese

画像診断と放射線治療の統合化に向けて 腫ようイメージングの進歩 腫ようの三次元的動態の可視化と同期
喜多村圭, SEPPENWOOLDE Y, 鬼丸力也, 清水伸一, 笹木工, 白土博樹, 宮坂和男
映像情報Medical, 34, 14, 1330-1335, 1320,1301, 産業開発機構, 01 Nov. 2002
Japanese

Small-volume image-guided radiotherapy using hypofractionated, coplanar, and noncoplanar multiple fields for patients with inoperable stage I nonsmall cell lung carcinomas
S Fukumoto, H Shirato, S Shimzu, S Ogura, R Onimaru, K Kitamura, K Yamazaki, K Miyasaka, M Nishimura, H Dosaka-Akita
CANCER, 95, 7, 1546, 1553, Oct. 2002, [Peer-reviewed]
English, Scientific journal

Real-time tumor-tracking radiation therapy for lung carcinoma by the aid of insertion of a gold marker using bronchofiberscopy
T Harada, H Shirato, S Ogura, S Oizumi, K Yamazaki, S Shimizu, R Onimaru, K Miyasaka, M Nishimura, H Dosaka-Akita
CANCER, 95, 8, 1720, 1727, Oct. 2002, [Peer-reviewed]
English, Scientific journal

脳腫瘍に対する放射線治療戦略 全脳画像の治療計画への利用　　　　　　　　　　　　　　　
白土 博樹, 青山 英史, 石井 伸明, 池田 潤, 澤村 豊, 鎌田 恭輔, 宮坂 和男, 岩埼 喜信
日本癌治療学会誌, 37, 2, 221, 221, (一社)日本癌治療学会, Sep. 2002
Japanese

新たに診断されたCNS胚細胞腫に対する減容量放射線照射を行う前の導入補助化学療法の長期追跡結果(Long-Term Follow-up Results of Induction Chemotherapy Followed by Reduced-Volume Irradiation for Newly Diagnosed CNS Germinoma)　　　　　　　　　　　　　　　
澤村 豊, 白土 博樹, 池田 潤, 青山 英史
日本癌治療学会誌, 37, 2, 222, 222, (一社)日本癌治療学会, Sep. 2002
English

頭頸部癌リンパ節転移陽性例に対する放射線化学療法の検討　　　　　　　　　　　　　　　
本間 明宏, 古田 康, 永橋 立望, 白土 博樹, 西岡 健, 八木 克憲, 影井 兼司, 犬山 征夫, 福田 諭
日本癌治療学会誌, 37, 2, 383, 383, (一社)日本癌治療学会, Sep. 2002
Japanese

Three-dimensional intrafractional movement of prostate measured during real-time tumor-tracking radiotherapy in supine and prone treatment positions
K Kitamura, H Shirato, Y Seppenwoolde, R Onimaru, M Oda, K Fujita, S Shimizu, N Shinohara, T Harabayashi, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 53, 5, 1117, 1123, Aug. 2002, [Peer-reviewed]
English, Scientific journal

Precise and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy
Y Seppenwoolde, H Shirato, K Kitamura, S Shimizu, M van Herk, JV Lebesque, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 53, 4, 822, 834, Jul. 2002, [Peer-reviewed]
English, Scientific journal

Image fusion between (18)FDG-PET and MRI/CT for radiotherapy planning of oropharyngeal and nasopharyngeal carcinomas
T Nishioka, T Shiga, H Shirato, E Tsukamoto, K Tsuchiya, T Kato, K Ohmori, A Yamazaki, H Aoyama, S Hashimoto, TC Chang, K Miyasaka
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 53, 4, 1051, 1057, Jul. 2002, [Peer-reviewed]
English, Scientific journal

T2N0声門癌の治療方針 放射線化学同時併用療法
永橋 立望, 福田 諭, 本間 明宏, 犬山 征夫, 白土 博樹
耳鼻と臨床, 48, Suppl.1, S41, S45, 耳鼻と臨床会, Jul. 2002
Japanese

Stereotactic irradiation using linear accelerator
H Shirato, H Aoyama, K Hida, Y Sawamura, K Miyasaka, Y Iwasaki
NEUROLOGICAL SURGERY, 30, 6, 579, 591, Jun. 2002, [Peer-reviewed]
Japanese

直線加速器を用いた定位放射線照射
白土 博樹, 青山 英史, 飛騨 一利, 澤村 豊, 宮坂 和男, 岩崎 喜信
Neurological Surgery, 30, 6, 579, 591, (株)医学書院, Jun. 2002
Japanese

頭頸部癌切除可能例に対するCDDP+RT vs CBDCA+RTの無作為化比較試験の検討　　　　　　　　　　　　　　　
本間 明宏, 福田 諭, 永橋 立望, 古田 康, 八木 克憲, 犬山 征夫, 白土 博樹, 西岡 健, 影井 兼司
頭頸部腫瘍, 28, 2, 380, 380, (一社)日本頭頸部癌学会, May 2002
Japanese

超選択的動注化学療法を施行した中・下咽頭癌症例における治療後の嚥下状態の検討　　　　　　　　　　　　　　　
鈴木 章之, 本間 明宏, 古田 康, 折館 伸彦, 永橋 立望, 畠山 博充, 福田 諭, 牛越 聡, 浅野 剛, 西岡 健, 白土 博樹
頭頸部腫瘍, 28, 2, 376, 376, (一社)日本頭頸部癌学会, May 2002
Japanese

A prospective, randomized trial comparing neoadjuvant chemotherapy with radiotherapy alone in patients with advanced nasopharyngeal carcinoma
M Hareyama, K Sakata, H Shirato, T Nishioka, M Nishio, K Suzuki, A Saitoh, A Oouchi, S Fukuda, T Himi
CANCER, 94, 8, 2217, 2223, Apr. 2002, [Peer-reviewed]
English, Scientific journal

Efficacy of intense screening and treatment for synchronous second primary cancers in patients with esophageal cancer
K Kagei, M Hosokawa, H Shirato, T Kusumi, Y Shimizu, A Watanabe, M Ueda
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 32, 4, 120, 127, Apr. 2002, [Peer-reviewed]
English, Scientific journal

Registration accuracy and possible migration of internal fiducial gold marker implanted in prostate and liver treated with real-time tumor-tracking radiation therapy (RTRT)
K Kitamura, H Shirato, S Shimizu, N Shinohara, T Harabayashi, T Shimizu, Y Kodama, H Endo, R Onimaru, S Nishioka, H Aoyama, K Tsuchiya, K Miyasaka
RADIOTHERAPY AND ONCOLOGY, 62, 3, 275, 281, Mar. 2002, [Peer-reviewed]
English, Scientific journal

Anisotrophic diffusion-weighted MRIを用いた錐体路情報の定位照射治療計画への統合　　　　　　　　　　　　　　　
青山 英史, 鎌田 恭輔, 白土 博樹, 宮坂 和男
日本医学放射線学会雑誌, 62, 3, S116, S116, (公社)日本医学放射線学会, Mar. 2002
Japanese

Induction chemotherapy followed by low-dose involved-field radiotherapy for intracranial germ cell tumors
H Aoyama, H Shirato, J Ikeda, K Fujieda, K Miyasaka, Y Sawamura
JOURNAL OF CLINICAL ONCOLOGY, 20, 3, 857, 865, Feb. 2002, [Peer-reviewed]
English, Scientific journal

動体追跡照射装置を用いた前立腺癌のConformal Set-up　　　　　　　　　　　　　　　
上垣 慎二, 白土 博樹, 喜多村 圭, 鬼丸 力也, 青山 英史, 米坂 祥朗, 井上 明大, 小前 隆, 土屋 和彦, 西岡 健
日本医学放射線学会雑誌, 62, 1, 47, 47, (公社)日本医学放射線学会, Jan. 2002
Japanese

動体追跡照射中における肺腫瘍の三次元的運動の解析　　　　　　　　　　　　　　　
喜多村 圭, 白土 博樹, 鬼丸 力也, 土屋 和彦, 西岡 井子, 西岡 健, 青山 英史, 宮坂 和男, Seppenwoolde Yvette
日本医学放射線学会雑誌, 62, 1, 46, 46, (公社)日本医学放射線学会, Jan. 2002
Japanese

頭蓋内原発胚細胞腫瘍に対する放射線治療の問題点 長期生存例における放射線誘発二次腫瘍と脳血管障害の発生について　　　　　　　　　　　　　　　
池田 潤, 澤村 豊, 石井 伸明, 岩崎 喜信, 青山 英史, 白土 博樹
小児がん, 38, 3, 374, 374, (NPO)日本小児がん学会, Dec. 2001
Japanese

肺定位照射における吸気・呼気・自由呼吸時と呼気時のみのCTでのDVH parameterの検討
鬼丸力也, 白土博樹, 喜多村圭, 清水伸一, 西岡健, 青山英史, 土屋和彦, 西岡井子, 宮坂和男
日本放射線腫よう学会誌, 13, Supplement 1, 114, 114, (公社)日本放射線腫瘍学会, Nov. 2001
Japanese

放射線医学の新展開 到達点と将来展望 放射線治療 定位放射線治療
清水伸一, 白土博樹, 喜多村圭
現代医療, 33, 10, 2585-2590, 2567, 現代医療社, 10 Oct. 2001
Japanese

Cisplatin抵抗性頭蓋内胚細胞腫瘍に対するgemcitabine/taxotere併用化学療法　　　　　　　　　　　　　　　
池田 潤, 石井 伸明, 澤村 豊, 岩崎 喜信, 青山 英史, 白土 博樹
日本癌治療学会誌, 36, 2, 590, 590, (一社)日本癌治療学会, Oct. 2001
Japanese

頭頸部腫瘍に対するCDDP+RT vs CBDCA+RTの無作為化比較試験　　　　　　　　　　　　　　　
本間 明宏, 福田 諭, 八木 克憲, 古田 康, 犬山 征夫, 白土 博樹, 西岡 健, 影井 兼司
日本癌治療学会誌, 36, 2, 594, 594, (一社)日本癌治療学会, Oct. 2001
Japanese

W11-1 気管支鏡による金マーカー挿入動体追跡放射線治療 (放射線治療の進歩)
原田 敏之, 小倉 滋明, 白土 博樹, 品川 尚文, 福元 伸一, 若林 修, 大泉 聡史, 本村 文宏, 山崎 浩一, 秋田 弘俊, 西村 正治, 鬼丸 力也, 清水 伸一, 喜多村 圭, 宮坂 和男
肺癌, 41, 5, 424, 424, 日本肺癌学会, 30 Sep. 2001
Japanese

小児後頭蓋窩悪性腫瘍に対する化学放射線療法
池田 潤, 石井 伸明, 澤村 豊, 岩崎 喜信, 青山 英史, 白土 博樹
小児の脳神経, 26, 4, 267, 267, (一社)日本小児神経外科学会, Aug. 2001
Japanese

頭蓋内原発胚芽腫に対する集学的治療 特にHCG-β陽性群のあつかいについて
石井 伸明, 池田 潤, 澤村 豊, 岩崎 喜信, 青山 英史, 白土 博樹
小児の脳神経, 26, 4, 316, 316, (一社)日本小児神経外科学会, Aug. 2001
Japanese

脊髄動静脈奇形・脊髄神経鞘腫に対する定位照射での画像レジストレーションと位置精度
鬼丸力也, 白土博樹, 喜多村圭, 清水伸一, 青山英史, 影井兼司, 土屋和彦, 西岡健, 宮坂和男
日本医学放射線学会雑誌, 61, 6, 319, 319, (公社)日本医学放射線学会, 25 May 2001
Japanese

頭頸部進行癌に対するシスプラチンの超選択的動注療法　　　　　　　　　　　　　　　
本間 明宏, 畠山 博充, 永橋 立望, 折舘 伸彦, 八木 克憲, 古田 康, 福田 諭, 犬山 征夫, 浅野 剛, 牛越 聡, 西岡 健, 白土 博樹, 宮坂 和男
頭頸部腫瘍, 27, 2, 356, 356, (一社)日本頭頸部癌学会, May 2001
Japanese

C-9 気管支鏡を用いた金マーカー挿入による動体追跡放射線治療
原田 敏之, 小倉 滋明, 品川 尚文, 白間 信行, 福元 伸一, 横内 浩, 若林 修, 大泉 聡史, 小島 哲弥, 山崎 浩一, 秋田 弘俊, 清水 伸一, 喜多村 圭, 白土 博樹
気管支学 : 日本気管支研究会雑誌, 23, 3, 244, 244, 日本呼吸器内視鏡学会, 25 Apr. 2001
Japanese

原発性・転移性肝腫ように対する動体追跡放射線治療の経験
喜多村圭, 白土博樹, 清水伸一, 橋本井子, 土屋和彦, 鬼丸力也, 青山英史, 影井兼司, 宮坂和男
日本医学放射線学会雑誌, 61, 4, 190, 190, (公社)日本医学放射線学会, 25 Mar. 2001
Japanese

動体追跡照射装置による照射中の肺癌の動態解析
清水伸一, 白土博樹, 喜多村圭, 青山英史, 鬼丸力也, 土屋和彦, 橋本井子, 宮坂和男, VAN HERK M
日本医学放射線学会雑誌, 61, 4, 191, 191, (公社)日本医学放射線学会, 25 Mar. 2001
Japanese

放射線治療におけるVirtualとRealのRegistration技術に関する考察
白土博樹, 鬼丸力也, 清水伸一, 橋本井子, 土屋和彦, 喜多村圭, 青山英史, 宮坂和男, 伊福部達
日本医学放射線学会雑誌, 61, 4, 192, 192, (公社)日本医学放射線学会, 25 Mar. 2001
Japanese

Stage B期の前立腺癌に対する局所放射線治療
喜多村圭, 白土博樹, 清水伸一, 橋本井子, 土屋和彦, 鬼丸力也, 青山英史, 影井兼司, 宮坂和男
日本医学放射線学会雑誌, 61, 4, 193, 193, (公社)日本医学放射線学会, 25 Mar. 2001
Japanese

線量率可変式全身照射用装置の使用経験　　　　　　　　　　　　　　　
井上 明大, 影井 兼司, 橋本 井子, 西岡 健, 喜多村 圭, 青山 英史, 鬼丸 力也, 土屋 和彦, 白土 博樹, 宮坂 和男
日本医学放射線学会雑誌, 61, 4, 190, 190, (公社)日本医学放射線学会, Mar. 2001
Japanese

頭頸部腫瘍の治療計画におけるFDGPETの利用　　　　　　　　　　　　　　　
西岡 健, 山崎 彰, 土屋 和彦, 青山 英史, 白土 博樹, 志賀 徹, 加藤 貴志, 塚本 江利子, 玉木 長良
日本医学放射線学会雑誌, 61, 4, 189, 189, (公社)日本医学放射線学会, Mar. 2001
Japanese

前立腺癌に対するIntensity modulated radiotherapy(IMRT) 動体追跡・内分泌療法併用によるprospective studyの初期成績
喜多村圭, 白土博樹, 清水伸一, 鬼丸力也, 西岡井子, 西岡健, 影井兼司, 土屋和彦, 宮坂和男
日本医学放射線学会雑誌, 61, 2, S128-S129, S129, (公社)日本医学放射線学会, 20 Feb. 2001
Japanese

FDGPETを用いた頭頸部癌の放射線治療計画　　　　　　　　　　　　　　　
西岡 健, 白土 博樹, 土屋 和彦, 山崎 彰, 志賀 哲, 塚本 江利子, 青山 英史, 宮坂 和男
日本医学放射線学会雑誌, 61, 2, S138, S138, (公社)日本医学放射線学会, Feb. 2001
Japanese

Pretreatment apoptotic scores do not predict response to radiation therapy in oropharyngeal squamous cell carcinoma
K Tsuchiya, H Shirato, T Nishioka, A Yamazaki, S Hashimoto, K Kagei, K Oomori, M Yasuda, M Shindo, K Miyasaka
ORAL ONCOLOGY, 37, 2, 159, 163, Feb. 2001, [Peer-reviewed]
English, Scientific journal

[Gated Radiotherapy]
Shirato H, Onimaru R, Kitamura K, Watanabe Y, Furuya T, Fujita K, Nangumo J, Oda M, Oita M
Igaku butsuri : Nihon Igaku Butsuri Gakkai kikanshi = Japanese journal of medical physics : an official journal of Japan Society of Medical Physics, 21, 1, 17, 27, 1, 2001, [Peer-reviewed]
Japanese, Recent external radiotherapy requires precise localization of the target because advance in diagnostic imaging has made it possible to visualize a tiny tumor which would be curable with focused high dose irradiation. However, tumors in respiratory and bowel organs have been difficult to be given the high dose because of 1 to 3 cm movement during delivery of irradiation. Respiratory-gating techniques have been used with medical linear accelerators and particle therapy machines. Real-time tumortracking radiotherapy has been realized using fluoroscopic x-rays, internal gold-markers, and pattern recognition technology. Advantage and disadvantage of each gating technique have been realized. Active breath control method would be a cost-effective way of precise treatment without gating. More work is required to find the relationship between abdominal wall and internal movement of the tumor in many respiratorygating radiotherapy and between the internal markers and target volume in real-time tracking radiotherapy.

Computer-controlled, image-guided, new conformal radiotherapy for advanced head and neck cancer - Results of AcMAR (Accelerated Multiple-arc Radiotherapy) study in Kitami Red-cross General Hospital
T Arimoto, A Yamazaki, T Matsuzawa, W Ichimura, K Nishioka, H Shirato
CARS 2001: COMPUTER ASSISTED RADIOLOGY AND SURGERY, 1230, 471, 476, 2001, [Peer-reviewed]
English, International conference proceedings

頭蓋内原発胚芽腫に対する集学的治療　　　　　　　　　　　　　　　
池田 潤, 石井 伸明, 澤村 豊, 岩崎 喜信, 青山 英史, 白土 博樹
小児がん, 37, 3, 370, 370, (NPO)日本小児がん学会, Nov. 2000
Japanese

Early detection of bone marrow involvement in extramedullary plasmacytoma by whole-body F-18FDG positron emission tomography
T Kato, E Tsukamoto, T Nishioka, A Yamazaki, H Shirato, S Kobayashi, M Asaka, M Imamura, N Tamaki
CLINICAL NUCLEAR MEDICINE, 25, 11, 870, 873, Nov. 2000, [Peer-reviewed]
English, Scientific journal

下咽頭癌における放射線・化学同時併用療法
永橋 立望, 福田 諭, 本間 明宏, 八木 克憲, 古田 康, 犬山 征夫, 西岡 健, 白土 博樹
頭頸部腫瘍, 26, 3, 476, 482, (一社)日本頭頸部癌学会, Nov. 2000
Japanese

視床部星細胞腫に対する放射線治療　　　　　　　　　　　　　　　
池田 潤, 澤村 豊, 石井 伸明, 青山 英史, 白土 博樹
日本脳神経外科学会総会抄録集, 59回, 235, 235, (一社)日本脳神経外科学会, Oct. 2000
Japanese

頭蓋内原発胚細胞腫瘍患者の長期生存例における放射線誘発脳血管障害の発生　　　　　　　　　　　　　　　
池田 潤, 澤村 豊, 石井 伸明, 青山 英史, 白土 博樹
日本脳神経外科学会総会抄録集, 59回, 91, 91, (一社)日本脳神経外科学会, Oct. 2000
Japanese

D-19 臨床病期I期非小細胞肺癌に対する定位放射線照射療法の臨床成績に関する検討
福元 伸一, 秋田 弘俊, 横内 浩, 原田 敏之, 若林 修, 小島 哲弥, 本村 文宏, 大泉 聡史, 山崎 浩一, 小倉 滋明, 白土 博樹, 清水 伸一, 立石 宇貴秀, 宮坂 和男
肺癌, 40, 5, 406, 406, 日本肺癌学会, 30 Sep. 2000
Japanese

W1-4 気管支鏡によるマーカー挿入動体追跡放射線治療の有用性の検討
原田 敏之, 小倉 滋明, 小西 純, 白間 信行, 福元 伸一, 横内 浩, 若林 修, 大泉 聡史, 小島 哲弥, 本村 文宏, 山崎 浩一, 秋田 弘俊, 清水 伸一, 白土 博樹, 宮坂 和男
肺癌, 40, 5, 363, 363, 日本肺癌学会, 30 Sep. 2000
Japanese

臨床病期I期非小細胞肺癌に対する定位放射線照射療法の臨床成績の検討
福元伸一, 秋田弘俊, 横内浩, 原田敏之, 若林修, 小島哲弥, 白土博樹, 清水伸一, 宮坂和男
日本癌治療学会誌, 35, 2, 520, 20 Sep. 2000
Japanese

前立腺癌への局所放射線治療の効果と副作用
喜多村圭, 鈴木恵士郎, 白土博樹, 西岡健, 影井兼司, 青山英史, 清水伸一, 篠原信雄, 出村孝義
泌尿器外科, 13, 8, 1133, 1133, 医学図書出版(株), 15 Aug. 2000
Japanese

体幹部定位放線照射における4次元治療計画と動体追跡放射線照射
白土博樹, 清水伸一, 清水匡, 喜多村圭, 青山英史, 西岡健, 影井兼司, 橋本井子, 宮坂和男
定位的放射線治療, 4, 131-136, 136, 日本定位放射線治療学会, 25 Jul. 2000
Japanese

頭頸部早期悪性リンパ腫に対するBiweekly CHOPと放射線治療　　　　　　　　　　　　　　　
西岡 健, 山崎 彰, 橋本 井子, 喜多村 圭, 土屋 和彦, 青山 英史, 清水 伸一, 影井 兼司, 白土 博樹, 宮坂 和男
日本医学放射線学会雑誌, 60, 8, 466, 466, (公社)日本医学放射線学会, Jul. 2000
Japanese

Astrocytoma及びOligodendrogliomaへの放射線照射の治療経験　　　　　　　　　　　　　　　
小前 隆, 青山 英史, 西岡 健, 橋本 井子, 山崎 彰, 清水 伸一, 喜多村 圭, 土屋 和彦, 白土 博樹, 宮坂 和男
日本医学放射線学会雑誌, 60, 8, 465, 465, (公社)日本医学放射線学会, Jul. 2000
Japanese

下咽頭癌のCT simulationにおける頸部リンパ節転移領域の解析　　　　　　　　　　　　　　　
山崎 彰, 西岡 健, 橋本 井子, 喜多村 圭, 土屋 和彦, 青山 英史, 清水 伸一, 影井 兼司, 白土 博樹, 宮坂 和男
日本医学放射線学会雑誌, 60, 8, 466, 466, (公社)日本医学放射線学会, Jul. 2000
Japanese

【前立腺癌の診断と治療】 前立腺癌の治療 集学的治療 内分泌療法併用動体追跡放射線治療　　　　　　　　　　　　　　　
喜多村 圭, 白土 博樹, 清水 伸一, 出村 孝義, 篠原 信雄, 原林 透, 宮坂 和男
日本臨床, 58, 増刊 前立腺癌の診断と治療, 326, 329, (株)日本臨床社, Jul. 2000
Japanese

下咽頭・頸部食道癌 治療成績・QOL向上の工夫 北大における下咽頭癌の治療成績 放射線・化学同時併用療法を中心として
永橋 立望, 福田 諭, 本間 明宏, 八木 克憲, 古田 康, 犬山 征夫, 西岡 健, 白土 博樹
頭頸部腫瘍, 26, 2, 204, 204, (一社)日本頭頸部癌学会, May 2000
Japanese

II-51 気管支鏡によるマーカー挿入動体追跡放射線治療の試み
小倉 滋明, 横内 浩, 福元 伸一, 原田 敏之, 若林 修, 小島 哲弥, 大泉 聡史, 岡本 佳裕, 尾島 裕和, 山崎 浩一, 秋田 弘俊, 川上 義和, 清水 伸一, 白土 博樹, 宮坂 和男, 斉藤 達也
気管支学 : 日本気管支研究会雑誌, 22, 3, 212, 212, 日本呼吸器内視鏡学会, 25 Apr. 2000
Japanese

上咽頭腫ようの局所残存および再発病変に対する3次元小容積照射
西岡健, 山崎彰, 橋本井子, 喜多村圭, 土屋和彦, 清水伸一, 青山英史, 白土博樹, 宮坂和男
日本医学放射線学会雑誌, 60, 2, S239, 20 Feb. 2000
Japanese

前立腺癌へのintensity modulated radiotherapy(IMRT)におけるreal‐time tumor‐tracking systemの有用性
喜多村圭, 白土博樹, 清水伸一, 土屋和彦, 山崎彰, 青山英史, 橋本井子, 西岡健, 宮坂和男
日本医学放射線学会雑誌, 60, 2, S235-S236, S236, (公社)日本医学放射線学会, 20 Feb. 2000
Japanese

Glioblastoma細胞の放射線感受性におけるp53遺伝子の役割 温度感受性p53変異細胞株を用いた検討
土屋和彦, 多田光宏, 白土博樹, 西岡健, 橋本井子, 青山英史, 喜多村圭, 清水伸一, 宮坂和男
日本医学放射線学会雑誌, 60, 2, S148-S149, S149, (公社)日本医学放射線学会, 20 Feb. 2000
Japanese

前立腺癌に対する局所放射線治療の長期成績と副作用の検討　　　　　　　　　　　　　　　
喜多村 圭, 清水 伸一, 森 孝之, 土屋 和彦, 山崎 彰, 青山 英史, 橋本 井子, 西岡 健, 白土 博樹, 宮坂 和男
日本医学放射線学会雑誌, 60, 3, 110, 110, (公社)日本医学放射線学会, Feb. 2000
Japanese

MRI治療計画装置を用いた頭蓋部病変三次元治療計画 複数観察者間の標的体積の検討　　　　　　　　　　　　　　　
青山 英史, 土屋 和彦, 橋本 井子, 西岡 健, 白土 博樹, 宮坂 和男
日本医学放射線学会雑誌, 60, 2, S218, S218, (公社)日本医学放射線学会, Feb. 2000
Japanese

上咽頭腫瘍の局所残存及び再発病変に対する三次元小容積照射　　　　　　　　　　　　　　　
西岡 健, 山崎 彰, 橋本 井子, 喜多村 圭, 土屋 和彦, 清水 伸一, 青山 英史, 白土 博樹, 宮坂 和男
日本医学放射線学会雑誌, 60, 2, S239, S239, (公社)日本医学放射線学会, Feb. 2000
Japanese

動体追跡放射線照射装置を用いた前立腺癌・膀胱癌への高精度conformal radiotherapyの経験　　　　　　　　　　　　　　　
喜多村 圭, 清水 伸一, 森 孝之, 土屋 和彦, 山崎 彰, 青山 英史, 橋本 井子, 西岡 健, 白土 博樹, 宮坂 和男
日本医学放射線学会雑誌, 60, 3, 110, 110, (公社)日本医学放射線学会, Feb. 2000
Japanese

Pilocytic astrocytomaへの三次元conformal放射線治療の経験　　　　　　　　　　　　　　　
森 孝之, 青山 英史, 清水 伸一, 喜多村 圭, 土屋 和彦, 山崎 彰, 橋本 井子, 西岡 健, 白土 博樹, 宮坂 和男
日本医学放射線学会雑誌, 60, 3, 108, 108, (公社)日本医学放射線学会, Feb. 2000
Japanese

Prevention of vaginal shortening following radical hysterectomy
Ritsu Yamamoto, Kazuhira Okamoto, Yasuhiko Ebina, Hiroki Shirato, Noriaki Sakuragi, Seiichiro Fujimoto
BJOG: An International Journal of Obstetrics and Gynaecology, 107, 7, 841, 845, 2000, [Peer-reviewed]
English, Scientific journal

Reconstruction of medical treatment and radiotherapy. The latest radiotherapy. Real-tome tumor-tracking irradiation method and stereotactic radioirradiation.
SHIRATO HIROKI, NISHIOKA TAKESHI, KAGEI KENJI, HASHIMOTO SEIKO, AOYAMA HIDEFUMI, KITAMURA KEI, SHIMIZU SHIN'ICHI, KUNIEDA TATSUYA, GOTO MASAHARU
月刊新医療, 26, 12, 61-63, 63, (株)エムイー振興協会, 01 Dec. 1999
Japanese

定位放射線照射,三次元原体照射による治療が有効であったpilocytic,fibrillary astrocytomaの4例　　　　　　　　　　　　　　　
森 孝之, 青山 英史, 白土 博樹, 西岡 健, 橋本 井子, 宮坂 和男
日本放射線腫瘍学会誌, 11, Suppl.1, 295, 295, (公社)日本放射線腫瘍学会, Nov. 1999
Japanese

下咽頭癌の化学療法 放射線同時併用療法
福田 諭, 永橋 立望, 本間 明宏, 犬山 征夫, 白土 博樹
耳鼻と臨床, 45, Suppl.3, 706, 709, 耳鼻と臨床会, Nov. 1999
Japanese

血管造影装置を配備した密封小線源治療施設における血管内小線源治療システムの開発と基礎的研究　　　　　　　　　　　　　　　
橋本 井子, 西岡 健, 土屋 和彦, 清水 伸一, 喜多村 圭, 山崎 彰, 青山 英史, 清水 匡, 白土 博樹, 宮坂 和男
日本放射線腫瘍学会誌, 11, Suppl.1, 311, 311, (公社)日本放射線腫瘍学会, Nov. 1999
Japanese

肺腫瘍45病変に対する定位的放射線治療の臨床成績　　　　　　　　　　　　　　　
清水 伸一, 白土 博樹, 喜多村 圭, 青山 英史, 橋本 井子, 西岡 健, 宮坂 和男
日本放射線腫瘍学会誌, 11, Suppl.1, 206, 206, (公社)日本放射線腫瘍学会, Nov. 1999
Japanese

頭蓋内,頭蓋底病変におけるMRI-planningの有用性 CT,MRIで定義されたGTVの複数観察者比較検討　　　　　　　　　　　　　　　
青山 英史, 土屋 和彦, 橋本 井子, 西岡 健, 山崎 彰, 喜多村 圭, 清水 伸一, 白土 博樹, 宮坂 和男
日本放射線腫瘍学会誌, 11, Suppl.1, 240, 240, (公社)日本放射線腫瘍学会, Nov. 1999
Japanese

前立腺癌に対する局所放射線治療後の晩期直腸出血に関する検討　　　　　　　　　　　　　　　
喜多村 圭, 鈴木 恵士郎, 土屋 和彦, 山崎 彰, 清水 伸一, 青山 英史, 橋本 井子, 西岡 健, 白土 博樹, 宮坂 和男
日本放射線腫瘍学会誌, 11, Suppl.1, 149, 149, (公社)日本放射線腫瘍学会, Nov. 1999
Japanese

Glioblastoma細胞の放射線感受性におけるp53遺伝子の役割 温度感受性p53変異細胞株を用いた検討　　　　　　　　　　　　　　　
土屋 和彦, 多田 光宏, 白土 博樹, 西岡 健, 橋本 井子, 青山 英史, 喜多村 圭, 清水 伸一, 山崎 彰, 宮坂 和男
日本放射線腫瘍学会誌, 11, Suppl.1, 169, 169, (公社)日本放射線腫瘍学会, Nov. 1999
Japanese

動体追跡照射装置の開発と初期臨床効果　　　　　　　　　　　　　　　
白土 博樹, 清水 伸一, 喜多村 圭, 清水 匡, 青山 英史, 山崎 彰, 橋本 井子, 西岡 健, 宮坂 和男
日本放射線腫瘍学会誌, 11, Suppl.1, 207, 207, (公社)日本放射線腫瘍学会, Nov. 1999
Japanese

頭頸部癌の至適臨床的標的体積決定のためのリンパ節転移分布の解析 下咽頭癌　　　　　　　　　　　　　　　
山崎 彰, 西岡 健, 白土 博樹, 橋本 井子, 喜多村 圭, 青山 英史, 清水 伸一, 土屋 和彦, 宮坂 和男
日本放射線腫瘍学会誌, 11, Suppl.1, 190, 190, (公社)日本放射線腫瘍学会, Nov. 1999
Japanese

【脳のイメージングupdate 解剖から治療まで】放射線治療 脳の定位放射線照射　　　　　　　　　　　　　　　
白土 博樹, 青山 英史
臨床放射線, 44, 11, 1478, 1488, 金原出版(株), Oct. 1999
Japanese

S2-5 末梢性小型肺癌への画像誘導定位放射線照射(肺末梢小型肺癌の治療成績向上をめざして,第40回日本肺癌学会総会号)
白土 博樹, 秋田 弘俊, 清水 伸一, 小倉 滋明, 喜多村 圭, 川上 義和, 宮坂 和男
肺癌, 39, 5, 525, 525, 日本肺癌学会, 25 Sep. 1999
Japanese

【Radiotherapy Today '99 放射線治療の最新動向】ライナックによる定位放射線照射の現状と展望
青山 英史, 白土 博樹
INNERVISION, 14, 10, 89, 92, (株)インナービジョン, Sep. 1999
Japanese

放射線治療計画用MRシステムの開発　　　　　　　　　　　　　　　
渡辺 良晴, 白土 博樹, 浅田 和佳, 前田 常雄, 影井 兼司, 西岡 健, 青山 英史, 橋本 井子, 清水 伸一, 南雲 淳也, 藤田 勝久, 古家 輝夫, 山口 恵, 宮坂 和男
メディックス, 31, 12, 17, (株)日立製作所ヘルスケアビジネスユニット, Sep. 1999
Japanese

【放射線治療の新潮流】MRI画像の放射線治療計画への応用
青山 英史, 渡辺 良晴, 古屋 輝夫, 橋本 井子, 影井 兼司, 西岡 健, 白土 博樹, 宮坂 和男
映像情報Medical, 31, 16, 895, 898, 産業開発機構(株), Aug. 1999
Japanese

【放射線治療の新潮流】 2軸X線透視装置を用いた三次元的患者セットアップシステムの開発
清水 伸一, 白土 博樹, 青山 英史, 宮坂 和男, 国枝 達也
映像情報Medical, 31, 16, 879, 884, 産業開発機構(株), Aug. 1999
Japanese

【放射線治療の新潮流】 次世代の放射線治療 動体追跡放射線治療　　　　　　　　　　　　　　　
白土 博樹, 清水 伸一, 喜多村 圭
映像情報Medical, 31, 16, 876, 878, 産業開発機構(株), Aug. 1999
Japanese

【MRIの到達点】北大における治療計画用MRIの概要と臨床応用　　　　　　　　　　　　　　　
青山 英史, 宮坂 和男, 白土 博樹, 渡辺 良晴, 古屋 輝夫, 影井 兼司
新医療, 26, 6, 109, 112, (株)エムイー振興協会, Jun. 1999
Japanese

脳動静脈奇形に対する定位照射後の出血に関わる因子の検討　　　　　　　　　　　　　　　
青山 英史, 白土 博樹, 西岡 健, 影井 兼司, 橋本 井子, 宮坂 和男
日本医学放射線学会雑誌, 59, 6, 278, 278, (公社)日本医学放射線学会, May 1999
Japanese

当科における中咽頭扁平上皮癌の頸部リンパ節転移の治療　　　　　　　　　　　　　　　
本間 明宏, 八木 克憲, 永橋 立望, 古田 康, 福田 諭, 犬山 征夫, 白土 博樹, 西岡 健, 影井 兼司
頭頸部腫瘍, 25, 2, 314, 314, (一社)日本頭頸部癌学会, May 1999
Japanese

MR治療計画システムの開発　　　　　　　　　　　　　　　
影井 兼司, 西岡 健, 橋本 井子, 青山 英史, 清水 伸一, 土屋 和彦, 橋 徳子, 白土 博樹, 宮坂 和男
日本医学放射線学会雑誌, 59, 6, 282, 282, (公社)日本医学放射線学会, May 1999
Japanese

Stereotactic Irradiation-from Three-dimensional to Four-dimensional Stereotaxy.
SHIRATO HIROKI, AOYAMA HIDEFUMI, SHIMIZU SHIN'ICHI
癌の臨床, 45, 4, 293-294, 01 Apr. 1999
Japanese

RADICAL RADIOTHERAPY FOR OROPHARYNGEAL CARCINOMAS
KAGEI Kenji, SHIMIZU Shinichi, HASHIMOTO Seiko, NISHIOKA Takeshi, SHIRATO Hiroki, HONMA Akihiro, KANEKO Masanori, OHMORI Keiichi, MIYASAKA Kazuo
Japanese jornal of Head and Neck Cancer, 25, 1, 30, 35, 25 Mar. 1999
Japanese

脳転移に対する定位放射線照射　　　　　　　　　　　　　　　
白土 博樹, 長谷川 正俊, 直居 豊, 林 靖之, 池田 裕子, 青山 英史, 柴山 千秋
日本放射線腫瘍学会誌, 10, Suppl.2, 34, 37, (公社)日本放射線腫瘍学会, Mar. 1999
Japanese

脳少分割定位照射の合併症に関する検討　　　　　　　　　　　　　　　
青山 英史, 白土 博樹, 西岡 健, 影井 兼司, 橋本 井子, 宮坂 和男
日本医学放射線学会雑誌, 59, 2, S234, S234, (公社)日本医学放射線学会, Feb. 1999
Japanese

血管造影装置を配備した密封小線源治療施設における血管内小線源治療システムの開発　　　　　　　　　　　　　　　
西岡 健, 清水 匡, 土屋 和彦, 清水 伸一, 山崎 彰, 青山 英史, 橋本 井子, 影井 兼司, 白土 博樹, 宮坂 和男
日本医学放射線学会雑誌, 59, 2, S191, S191, (公社)日本医学放射線学会, Feb. 1999
Japanese

放射線治療計画専用MRIの開発及びその臨床応用　　　　　　　　　　　　　　　
影井 兼司, 土屋 和彦, 清水 伸一, 山崎 彰, 青山 英史, 橋本 井子, 西岡 健, 白土 博樹, 宮坂 和男
日本医学放射線学会雑誌, 59, 2, S188, S188, (公社)日本医学放射線学会, Feb. 1999
Japanese

2軸X線透視装置を用いた三次元的患者セットアップシステムの開発
清水 伸一, 白土 博樹, 西岡 健, 影井 兼司, 橋本 井子, 青山 英史, 山崎 彰, 土屋 和彦, 宮坂 和男, 国枝 達也
日本医学放射線学会雑誌, 59, 2, S189, S189, (公社)日本医学放射線学会, Feb. 1999
Japanese

Spinal cord compressionに対する放射線治療開始時期と効果 緊急照射に対する遠隔放射線治療支援システムTHERAPISの利用　　　　　　　　　　　　　　　
橋本 井子, 白土 博樹, 西岡 健, 影井 兼司, 清水 伸一, 山崎 彰, 青山 英史, 土屋 和彦, 瀬川 広志, 小笠原 弘
日本医学放射線学会雑誌, 59, 2, S67, S68, (公社)日本医学放射線学会, Feb. 1999
Japanese

Role of radiotherapy for mucoepidermoid carcinoma of salivary gland
Y Hosokawa, H Shirato, K Kagei, S Hashimoto, T Nishioka, K Tei, M Ono, K Ohmori, M Kaneko, K Miyasaka, M Nakamura
ORAL ONCOLOGY, 35, 1, 105, 111, Jan. 1999, [Peer-reviewed]
English, Scientific journal

中咽頭腫瘍の予後因子の検討　　　　　　　　　　　　　　　
土屋 和彦, 西岡 健, 影井 兼司, 橋本 井子, 清水 伸一, 山崎 彰, 青山 英史, 白土 博樹, 宮坂 和男
日本医学放射線学会雑誌, 58, 14, 855, 855, (公社)日本医学放射線学会, Dec. 1998
Japanese

子宮頸癌の術後放射線治療　　　　　　　　　　　　　　　
山崎 彰, 西岡 健, 影井 兼司, 橋本 井子, 清水 伸一, 土屋 和彦, 青山 英史, 白土 博樹, 宮坂 和男
日本医学放射線学会雑誌, 58, 14, 859, 859, (公社)日本医学放射線学会, Dec. 1998
Japanese

【頭頸部癌 私の治療方針と成績】 声帯癌T3症例の保存的治療 北海道大学病院の場合
犬山 征夫, 福田 諭, 古田 康, 本間 明宏, 白土 博樹
耳鼻咽喉科・頭頸部外科, 70, 12, 799, 804, (株)医学書院, Nov. 1998
Japanese

舌腫瘍の超音波所見　　　　　　　　　　　　　　　
土屋 和彦, 橋本 井子, 青山 英史, 朱 強, 唐 少珊, 白土 博樹, 北原 利博, 影井 兼司, 清水 匡, 宮坂 和男
超音波医学, 25, 9, 967, 967, (公社)日本超音波医学会, Sep. 1998
Japanese

頭蓋内胚細胞腫に対する照射前化学療法と限局照射野を用いた低線量放射線治療　　　　　　　　　　　　　　　
白土 博樹, 喜多村 圭, 青山 英史, 宮坂 和男, 澤村 豊, 池田 潤
小児がん, 35, 3, 439, 439, (NPO)日本小児がん学会, Sep. 1998
Japanese

中咽頭がんの治療 頭頚部外科医と放射線治療医との対話 中咽頭癌に対する根治的放射線治療
影井兼司, 清水伸一, 橋本井子, 西岡健, 白土博樹, 金子正範, 大森圭一, 本間明宏, 宮坂和男
頭頚部腫よう, 24, 2, 148, May 1998
Japanese

The Experience of Teleradiology in Radiotherapy Planning
小笠原 弘, 白土 博樹, 橋本 井子, 瀬川 広志
Japanese Journal of Radiological Technology, 54, 9, 1121, 1121, Japanese Society of Radiological Technology, 1998
Japanese

Small volume Multiple non-coplanar Arc Radiotherapy (SMART) for tumors of the lung, head & neck and the abdominopelvic region.
T Arimoto, H Usubuchi, T Matsuzawa, A Yonesaka, S Shimizu, H Shirato, K Miyasaka
CAR '98 - COMPUTER ASSISTED RADIOLOGY AND SURGERY, 1165, 257, 261, 1998, [Peer-reviewed]
English, International conference proceedings

A telecommunications helped radiotherapy planning and information system (THERAPIS)
S Hashimoto, H Shirato, K Inamura, J Mizuno, Y Watanabe, H Ogawawara, M Hosokawa, K Miyasaka
CAR '98 - COMPUTER ASSISTED RADIOLOGY AND SURGERY, 1165, 276, 281, 1998, [Peer-reviewed]
English, International conference proceedings

放射線治療の最前線 定位的放射線照射の現況
青山 英史, 白土 博樹
映像情報Medical, 29, 16, 946, 950, 産業開発機構(株), Aug. 1997
Japanese

Three-dimensional movement of lung and liver tumors during noncoplaner external radiotherapy analyzed by high speed computed tomography (CT) and magnetic resonance imaging (MRI).
Shimizu S, Shirato H, Kagei K, Kitahara T, Hashimoto S, Miyasaka
International Journal of Radiation Oncology Biology Physics, 39, 2, 347, 1997, [Peer-reviewed]

SUPERFICIAL ESOPHAGEAL CANCER - MULTICENTER ANALYSIS OF RESULTS OF DEFINITIVE RADIATION-THERAPY IN JAPAN
T OKAWA, M TANAKA, M KITAOKAWA, M NISHIO, Y KIKUCHI, H SHIRATO, S YAMADA, H ASAKAWA, H NIIBE, T DOKIYA, Y TANAKA, Y HISHIKAWA, S HIROTA, Y IMAJO, Y HIROKAWA, N HAYABUCHI, N MIYAJI
RADIOLOGY, 196, 1, 271, 274, Jul. 1995, [Peer-reviewed]
English, Scientific journal

Application of computer picture archiving and communicating system (PACS) to stereotactic radiosurgery (SRS)
T. Shiga, H. Shirato, Y. Kikuchi, N. Nishiyama, K. Nishioka, T. Kitahara, S. Terae, K. Miyasaka
Proceedings of the 4th International Conference on Image Management and Communication: Medical Imaging Service in a Network Environment, IMAC 1995, 187, 191, Institute of Electrical and Electronics Engineers Inc., 1995
English, International conference proceedings

Recent topics in chemotherapy for head and neck cancer
Y Inuyama, S Fukuda, T Kamata, H Shirato, M Fujii, J Kanzaki, M Horiuchi
CANCER CHEMOTHERAPY: CHALLENGES FOR THE FUTURE, VOL 10, 1110, 109, 119, 1995, [Peer-reviewed]
English, International conference proceedings

RADIOTHERAPY DEDICATED CT SYSTEM - RT-CT SYSTEM - THE HOKKAIDO-UNIVERSITY EXPERIENCE
T KAMADA, H TSUJII, G IRIE, J MIZOE, T ARIMOTO, H SHIRATO, A TAKAMURA
PROCEEDINGS OF THE XVI INTERNATIONAL CANCER CONGRESS - FREE PAPERS AND POSTERS, TOMES 1-4, 2713, 2717, 1994, [Peer-reviewed]
English, International conference proceedings

Prof.　　　　　　　　　　　　　　　
SHIRATO Hiroki
[Peer-reviewed]

Radiation-induced intracellular trafficking and secretory factors
NAM Jin-Min, 小野寺康仁, WU Ping-Hsiu, 西岡蒼一郎, 白土博樹, 放射線生物研究, 56, 4, 2022

がん治療における緩和的放射線治療の評価と普及啓発のための研究 放射線治療を含むがん治療の経済毒性と両立支援に関する研究
青山英史, 白土博樹, 西岡健太郎, 岩崎由加子, 高橋健夫, 原田英幸, 立石清一郎, 内海暢子, 浅川勇雄, がん治療における緩和的放射線治療の評価と普及啓発のための研究 令和3年度 総括・分担研究報告書(Web), 2022

中小企業等における治療と仕事の両立支援の取り組み促進のための研究「治療と仕事の両立支援」に資する大学病院モデルの構築
白土博樹, 西岡健太郎, 岩崎由加子, 渋谷麻実, 本多和典, 梶本祐介, 五十嵐中, 五十嵐中, 中小企業等における治療と仕事の両立支援の取り組み促進のための研究 令和3年度 総括・分担研究報告書(Web), 2022

SLD repair impact on prolonged proton irradiation with various cell specific parameters
KASAMATSU Koki, MATSUURA Taeko, MATSUURA Taeko, TAKAO Seishin, TAKAO Seishin, TANAKA Sodai, TANAKA Sodai, MIYAMOTO Naoki, MIYAMOTO Naoki, NAM Jin-Min, SHIRATO Hiroki, SHIRATO Hiroki, UMEGAKI Kikuo, UMEGAKI Kikuo, 日本医学物理学会学術大会報文集, 119th, 2020

局所進行食道癌に対してspot scanning法による根治的化学陽子線療法を施行した一例　　　　　　　　　　　　　　　
宮崎 智彦, 打浪 雄介, 田口 大志, 加藤 徳雄, 清水 伸一, 白土 博樹, 中積 宏之, 中野 真太郎, 坂本 直哉, 高尾 聖心, 田村 昌也, 松浦 妙子, 日本医学放射線学会秋季臨床大会抄録集, 55回, S520, S520, Sep. 2019
(公社)日本医学放射線学会, Japanese

Bladder-preserving therapy using a real-time tumor-tracking radiotherapy system for muscle-invasive bladder cancer.
Haruka Miyata, Takahiro Osawa, Jun Frumido, Hiroshi Kikuchi, Ryuji Matsumoto, Takashige Abe, Satoru Maruyama, Kentaro Nishioka, Shinichi Shimizu, Takayuki Hashimoto, Hiroki Shirato, Nobuo Shinohara, JOURNAL OF CLINICAL ONCOLOGY, 37, 7, Mar. 2019
English, Summary international conference

A retrospective analysis of neoadjuvant chemotherapy followed by surgery or definitive chemoradiotherapy in patients with advanced esophageal squamous cell carcinoma.
Hiroshi Nakatsumi, Yoshito Komatsu, Shintaro Nakano, Kentaro Sawada, Tetsuhito Muranaka, Yasuyuki Kawamoto, Satoshi Yuki, Yusuke Uchinami, Hiroshi Taguchi, Hiroki Shirato, Yuma Ebihara, Toshiaki Shichinohe, Satoshi Hirano, Naoya Sakamoto, JOURNAL OF CLINICAL ONCOLOGY, 37, 4, Feb. 2019
English, Summary international conference

グリオブラストーマの放射線治療抵抗性におけるRab27bの関与
西岡蒼一郎, 西岡蒼一郎, 呉秉修, 小野寺康仁, 小野寺康仁, 清水伸一, 清水伸一, 白土博樹, 白土博樹, 南しんびん, 南しんびん, 日本分子生物学会年会プログラム・要旨集(Web), 42nd, 2019

Automatic metastatic bone tumor classification with DCNN-based features using treatment-planning CT
Haruna Watanabe, Ren Togo, Takahiro Ogawa, Miki Haseyama, Koichi Yasuda, Khin Khin Tha, Kohsuke Kudo, Hiroki Shirato, Proceedings of SPIE - The International Society for Optical Engineering, 11050, 01 Jan. 2019

放射線治療用微粒子マーカの実現可能性の検証
森田亮, 阿保大介, 曽山武士, 工藤與亮, 白土博樹, 作原祐介, IVR, 33, 3, 314, 25 Nov. 2018
Japanese

Big Data Analysis of Treatment Process Time for the Real-Time-Image Gated-Spot-Scanning Proton-Beam Therapy (RGPT) System
T. Yoshimura, S. Shimizu, T. Hashimoto, N. Katoh, T. Inoue, K. Nishioka, T. Matsuura, S. Takao, M. Tamura, H. Tamura, K. Horita, K. Umegaki, H. Shirato, International Journal of Radiation Oncology*Biology*Physics, 102, 3, e501, e502, Nov. 2018, [Peer-reviewed]
Elsevier BV, Summary international conference

深層学習に基づく画像特徴量を利用した放射線治療用CT画像における転移性骨腫瘍の検出に関する検討
渡邊はるな, 藤後廉, 小川貴弘, 長谷山美紀, 安田耕一, THA Khin Khin, 工藤與亮, 白土博樹, 電気・情報関係学会北海道支部連合大会講演論文集(CD-ROM), 2018, ROMBUNNO.87, 27 Oct. 2018
Japanese

前立腺癌治療の新たな展開:ハイリスク前立腺癌に対する拡大手術、粒子線治療、ネオアジュバント治療 ハイリスク前立腺がんに対する強度変調放射線治療・陽子線治療 現状と可能性　　　　　　　　　　　　　　　
清水 伸一, 橋本 孝之, 西岡 健太郎, 安部 崇重, 大澤 崇宏, 松本 隆児, 松浦 妙子, 宮本 直樹, 高尾 聖心, 鈴木 隆介, 梅垣 菊男, 篠原 信雄, 白土 博樹, 日本癌治療学会学術集会抄録集, 56回, SY5, 2, Oct. 2018
(一社)日本癌治療学会, English

全脳全脊髄強度変調陽子線照射が骨髄抑制軽減に有用であったAYA世代胚細胞腫瘍の2例
橋本孝之, 井口晶裕, 寺坂俊介, 杉山未奈子, 山口秀, 小林浩之, 長祐子, 鬼丸力也, 清水伸一, 白土博樹, 日本小児科学会雑誌, 122, 7, 1240, 1240, 01 Jul. 2018
(公社)日本小児科学会, Japanese

Improvement of the repeatability of parallel transmission at 7T using interleaved acquisition in the calibration scan.
Hiroyuki Kameda, Kohsuke Kudo, Tsuyoshi Matsuda, Taisuke Harada, Yuji Iwadate, Ikuko Uwano, Fumio Yamashita, Kunihiro Yoshioka, Makoto Sasaki, Hiroki Shirato, Journal of magnetic resonance imaging : JMRI, 48, 1, 94, 101, Jul. 2018, [International Magazine]
English

全脳全脊髄強度変調陽子線照射(IMPT)が骨髄抑制軽減に有用であったAYA世代胚細胞腫瘍の2例　　　　　　　　　　　　　　　
橋本 孝之, 寺坂 俊介, 井口 晶裕, 山口 秀, 小林 浩之, 杉山 未奈子, 長 祐子, 森 崇, 高尾 聖心, 松浦 妙子, 鬼丸 力也, 清水 伸一, 白土 博樹, 日本小児血液・がん学会雑誌, 55, 1, 76, 76, Jun. 2018
(一社)日本小児血液・がん学会, Japanese

聴神経鞘腫に対する定位放射線治療後に腫瘍内出血を来した2例
打浪雄介, 鬼丸力也, 白土博樹, 森崇, 山口秀, 寺坂俊介, 小林浩之, 藤原圭志, 本間明宏, Japanese Journal of Radiology, 36, Supplement, 8, 8, 25 Feb. 2018
(公社)日本医学放射線学会, Japanese

ヘリウム・陽子線ハイブリッド治療に関する考察(コンセプト)
白土博樹, 清水伸一, 鬼丸力也, 高尾聖心, 松浦妙子, 梅垣菊雄, Japanese Journal of Radiology, 36, Supplement, 7, 7, 25 Feb. 2018
(公社)日本医学放射線学会, Japanese

A note on classification of brain metastases from MR images based on machine learning
菅田健斗, 小川貴弘, 長谷山美紀, THA Khin Khin, THA Khin Khin, 工藤與亮, 工藤與亮, 白土博樹, 白土博樹, 電子情報通信学会技術研究報告, 117, 431, 311, 314, 15 Feb. 2018
電子情報通信学会, Japanese

乳癌眼窩尖部転移により視力低下をきたし、放射線治療により著明な改善を認めた1例　　　　　　　　　　　　　　　
湊川 英樹, 安田 耕一, 打浪 雄介, 白土 博樹, 土屋 和彦, 加藤 徳雄, 木下 留美子, 石田 直子, 山下 啓子, 石嶋 漢, Japanese Journal of Radiology, 36, Suppl., 11, 11, Feb. 2018
(公社)日本医学放射線学会, Japanese

A note on classification of brain metastases from MR images based on machine learning
菅田 健斗, 小川 貴弘, 長谷山 美紀, タ キンキン, 工藤 與亮, 白土 博樹, 映像情報メディア学会技術報告 = ITE technical report, 42, 4, 311, 314, Feb. 2018
映像情報メディア学会, Japanese

Heterogeneity of longitudinal and circumferential contraction in relation to late gadolinium enhancement in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction.
Keita Sakamoto, Noriko Oyama-Manabe, Osamu Manabe, Tadao Aikawa, Yasuka Kikuchi, Harue Sasai-Masuko, Masanao Naya, Kohsuke Kudo, Fumi Kato, Nagara Tamaki, Hiroki Shirato, Japanese journal of radiology, 36, 2, 103, 112, Feb. 2018, [Domestic magazines]
English

Pulmonary tumor thrombotic microangiopathy(PTTM)の1例-生前~死後CT,そして解剖との対比-
吉野裕紀, 菊池穏香, 菊池穏香, 常田慧徳, 加藤扶美, 加藤扶美, 工藤與亮, 工藤與亮, 仲川心平, 田中敏, 白土博樹, 白土博樹, 日本医学放射線学会秋季臨床大会抄録集, 54th, 2018

全脳全脊髄照射におけるスポットスキャニング陽子線治療とIMRTによる誘発二次発がん率の比較
鈴木俊介, 田村昌也, 鈴木隆介, 高尾聖心, 橋本孝之, 清水伸一, 白土博樹, 日本放射線腫瘍学会高精度放射線外部照射部会学術大会プログラム・抄録集, 31st (CD-ROM), 2018

リンパ脈管筋腫症(LAM)を合併した乳癌に対し乳房温存術後に術後照射を施行した2例
木下留美子, 長江伸樹, 西岡健太郎, 橋本孝之, 清水伸一, 白土博樹, 加藤扶美, 石田直子, 山下啓子, 清水薫子, 鈴木雅, 今野哲, 北海道外科雑誌, 63, 2, 2018

Prostate position deviation analysis using real-time-image gated spot-scanning proton therapy (RGPT) system for prostate cancer
TAMURA Hiroshi, TAMURA Hiroshi, SHIMIZU Shinichi, NISHIOKA Kentaro, HASHIMOTO Takayuki, YOSHIMURA Takaaki, MATSUO Yuto, MATSUURA Taeko, MATSUURA Taeko, TAKAO Seishin, UMEGAKI Kikuo, UMEGAKI Kikuo, SHIRATO Hiroki, 医学物理 Supplement, 38, 1, 2018

放射線治療における数値指標の医学物理的利用
清水伸一, 小橋啓司, 伊藤陽一, PRAYONGRAT Anussara, 加藤徳雄, 安田耕一, 出倉康裕, 木元拓也, 白土博樹, 日本放射線腫瘍学会高精度放射線外部照射部会学術大会プログラム・抄録集, 31st (CD-ROM), 39, 2018
Japanese

Simple modification of arm position improves B1+ and signal homogeneity in the thoracolumbar spine at 3T.
Kinya Ishizaka, Kohsuke Kudo, Kuniaki Harada, Toru Shirai, Taro Fujiwara, Suzuko Aoike, Sayaka Takamori, Hiroki Shirato, Journal of magnetic resonance imaging : JMRI, 47, 1, 123, 130, Jan. 2018, [International Magazine]
English

Noninvasive electrical conductivity measurement by MRI: a test of its validity and the electrical conductivity characteristics of glioma.
Khin Khin Tha, Ulrich Katscher, Shigeru Yamaguchi, Christian Stehning, Shunsuke Terasaka, Noriyuki Fujima, Kohsuke Kudo, Ken Kazumata, Toru Yamamoto, Marc Van Cauteren, Hiroki Shirato, European radiology, 28, 1, 348, 355, Jan. 2018, [International Magazine]
English

Characteristics of immunoglobulin G4-related aortitis/periaortitis and periarteritis on fluorodeoxyglucose positron emission tomography/computed tomography co-registered with contrast-enhanced computed tomography.
Satoshi Yabusaki, Noriko Oyama-Manabe, Osamu Manabe, Kenji Hirata, Fumi Kato, Noriyuki Miyamoto, Yoshihiro Matsuno, Kohsuke Kudo, Nagara Tamaki, Hiroki Shirato, EJNMMI research, 7, 1, 20, 20, Dec. 2017, [International Magazine]
English

Benefits of Craniospinal Intensity-modulated Proton Beam Therapy in Reducing the Myelosuppression for Adolescent Germ Cell Tumors: Two Case Reports
Takayuki Hashimoto, Syunsuke Terasaka, Akihiro Iguchi, Shigeru Yamaguchi, Hiroyuki Kobayashi, Minako Sugiyama, Yuko Cho, Takashi Mori, Seishin Takao, Taeko Matsuura, Rikiya Onimaru, Shinichi Shimizu, Hiroki Shirato, PEDIATRIC BLOOD & CANCER, 64, S87, S88, Nov. 2017
English, Summary international conference

An Organ Motion and Acute Toxicity Study of Image-Guided Spot-Scanning Proton Beam Therapy With An Internal Fiducial Marker for Pancreatic Cancers.
Y. Uchinami, N. Katoh, D. Abo, K. Harada, Y. Nishikawa, T. Inoue, T. Hashimoto, R. Onimaru, N. Miyamoto, Y. Sakuhara, S. Shimizu, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 99, 2, E194, E194, Oct. 2017
English, Summary international conference

Long-Term Outcomes of Proton Therapy for Prostate Cancer in Japan: Retrospective Analysis of a Multi-institutional Survey
H. Iwata, H. Ishikawa, M. Takagi, T. Okimoto, S. Murayama, T. Akimoto, H. Wada, T. Arimura, Y. Sato, M. Araya, J. E. Mizoe, H. Shirato, H. Sakurai, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 99, 2, E241, E242, Oct. 2017
English, Summary international conference

Analysis of Threshold Doses for Radiation Induced Liver Parenchymal Changes on MRI after Real TimeeImage Gated Spot-Scanning Proton Beam Therapy of Hepatocellular Carcinomas
N. Katoh, Y. Uchinami, S. Takao, K. Yasuda, K. Harada, T. Inoue, T. Matsuura, T. Hashimoto, S. Shimizu, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 99, 2, E159, E160, Oct. 2017
English, Summary international conference

Can F-18-fluoromisonidazole PET/CT Predict the Clinical Outcome for Stage I Non-small Cell Lung Cancer Treated By Stereotactic Body Radiation Therapy?
T. Inoue, S. Watanabe, K. Harada, K. Yasuda, N. Katoh, S. Okamoto, T. Shiga, Y. Kuge, N. Tamaki, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 99, 2, E466, E466, Oct. 2017
English, Summary international conference

Kasabach-Merritt症候群を合併した血管腫に対する陽子線治療の有用性について　　　　　　　　　　　　　　　
渡邊 敏史, 井口 晶裕, 長 祐子, 杉山 未奈子, 廣瀬 文, 森 崇, 高尾 聖心, 橋本 孝之, 鬼丸 力也, 清水 伸一, 白土 博樹, 日本小児血液・がん学会雑誌, 54, 4, 347, 347, Oct. 2017
(一社)日本小児血液・がん学会, Japanese

Identifying Relations Between Imaging Phenotypes and Molecular Subtypes of Breast Cancer: Model Discovery and External Validation
Jia Wu, Xiaoli Sun, Jeff Wang, Yi Cui, Fumi Kato, Hiroki Shirato, Debra M. Ikeda, Ruijiang Li, JOURNAL OF MAGNETIC RESONANCE IMAGING, 46, 4, 1017, 1027, Oct. 2017
English

Educational outcomes of a medical physicist program over the past 10 years in Japan
Noriyuki Kadoya, Kumiko Karasawa, Iori Sumida, Hidetaka Arimura, Yasumasa Kakinohana, Shigeto Kabuki, Hajime Monzen, Teiji Nishio, Hiroki Shirato, Syogo Yamada, JOURNAL OF RADIATION RESEARCH, 58, 5, 669, 674, Sep. 2017
English

Volume of high-risk intratumoral subregions at multi-parametric MR imaging predicts overall survival and complements molecular analysis of glioblastoma
Yi Cui, Shangjie Ren, Khin Khin Tha, Jia Wu, Hiroki Shirato, Ruijiang Li, EUROPEAN RADIOLOGY, 27, 9, 3583, 3592, Sep. 2017
English

Local relapse of nasopharyngeal cancer and Voxel-based analysis of FMISO uptake using PET with semiconductor detectors
Yukiko Nishikawa, Koichi Yasuda, Shozo Okamoto, Yoichi M. Ito, Rikiya Onimaru, Tohru Shiga, Kazuhiko Tsuchiya, Shiro Watanabe, Wataru Takeuchi, Yuji Kuge, Hao Peng, Nagara Tamaki, Hiroki Shirato, RADIATION ONCOLOGY, 12, Sep. 2017
English

北海道大学の死因究明教育研究センターでのオートプシーイメージング部門および放射線診断医の役割
菊池穏香, 吉野裕紀, 工藤與亮, 工藤與亮, 加藤扶美, 加藤扶美, 南須原康行, 南須原康行, 南須原康行, 品川尚文, 清水康, 田中敏, 兵頭秀樹, 的場光太郎, 的場光太郎, 三上八郎, 田中伸哉, 田中伸哉, 白土博樹, 白土博樹, 日本医学放射線学会秋季臨床大会抄録集, 53rd, S506, 18 Aug. 2017
Japanese

Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells
Ping-Hsiu Wu, Yasuhito Onodera, Yuki Ichikawa, Erinn B. Rankin, Amato J. Giaccia, Yuko Watanabe, Wei Qian, Takayuki Hashimoto, Hiroki Shirato, Jin-Min Nam, International Journal of Nanomedicine, 12, 5069, 5085, 14 Jul. 2017
Dove Medical Press Ltd., English

肝腫瘍に対する動態追跡照射のための経皮的マーカ留置
森田 亮, 曽山 武士, 阿保 大介, 作原 祐介, 工藤 與亮, 加藤 徳雄, 白土 博樹, IVR: Interventional Radiology, 32, 2, 161, 161, Jul. 2017
(一社)日本インターベンショナルラジオロジー学会, Japanese

A simulation study on the dosimetric benefit of real-time motion compensation in spot-scanning proton therapy for prostate
Yusuke Fujii, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Takaaki Fujii, Naoki Miyamoto, Kikuo Umegaki, Kentaro Nishioka, Shinichi Shimizu, Hiroki Shirato, JOURNAL OF RADIATION RESEARCH, 58, 4, 591, 597, Jul. 2017
English

甲状腺癌分化癌の骨転移に対するIMRTを含めた外照射の治療成績
安田耕一, 加藤徳雄, 岡本祥三, 木下留美子, 志賀哲, 水町貴諭, 畠山博充, 本間明宏, 田口純, 清水康, 森崇, 土屋和彦, 白土博樹, 頭けい部癌, 43, 2, 221, 221, 10 May 2017
日本頭頸部癌学会, Japanese

Non-invasive prediction of the tumor growth rate using advanced diffusion models in head and neck squamous cell carcinoma patients
Noriyuki Fujima, Tomohiro Sakashita, Akihiro Homma, Taisuke Harada, Yukie Shimizu, Khin Khin Tha, Kohsuke Kudo, Hiroki Shirato, ONCOTARGET, 8, 20, 33631, 33643, May 2017
English

Residual tumour detection in post-treatment granulation tissue by using advanced diffusion models in head and neck squamous cell carcinoma patients
Noriyuki Fujima, Daisuke Yoshida, Tomohiro Sakashita, Akihiro Homma, Kohsuke Kudo, Hiroki Shirato, EUROPEAN JOURNAL OF RADIOLOGY, 90, 14, 19, May 2017
English

Lifetime attributable risk of radiation-induced secondary cancer from proton beam therapy compared with that of intensity-modulated X-ray therapy in randomly sampled pediatric cancer patients
Masaya Tamura, Hideyuki Sakurai, Masashi Mizumoto, Satoshi Kamizawa, Shigeyuki Murayama, Haruo Yamashita, Seishin Takao, Ryusuke Suzuki, Hiroki Shirato, Yoichi M. Ito, JOURNAL OF RADIATION RESEARCH, 58, 3, 363, 371, May 2017
English

肝腫瘍に対する動態追跡照射のための経皮的マーカ留置(Percutaneous hepatic fiducial marker implantation for Real-time Tumor-tracking Radiotherapy(RTRT))　　　　　　　　　　　　　　　
森田 亮, 作原 祐介, 曽山 武士, 阿保 大介, 加藤 徳雄, 工藤 與亮, 白土 博樹, IVR: Interventional Radiology, 32, Suppl., 173, 173, Apr. 2017
(一社)日本インターベンショナルラジオロジー学会, English

Commissioning of Eclipse Treatment Planning System for Spot-scanning Nozzle in Hokkaido University Proton Therapy Center
YOSHIMURA Takaaki, YOSHIMURA Takaaki, MATSUO Yuto, MATSUURA Taeko, MATSUURA Taeko, TAKAO Seishin, FUJII Takaaki, HIRAYAMA Shusuke, UMEGAKI Kikuo, SHIMIZU Shinichi, SHIRATO Hiroki, 医学物理 Supplement, 37, 1, 176, 01 Apr. 2017
English

Automatic Estimation of Volumetric Breast Density Using Artificial Neural Network-Based Calibration of Full-Field Digital Mammography: Feasibility on Japanese Women With and Without Breast Cancer
Jeff Wang, Fumi Kato, Hiroko Yamashita, Motoi Baba, Yi Cui, Ruijiang Li, Noriko Oyama-Manabe, Hiroki Shirato, JOURNAL OF DIGITAL IMAGING, 30, 2, 215, 227, Apr. 2017
English

Long-term follow-up after proton beam therapy for pediatric tumors: a Japanese national survey
Masashi Mizumoto, Shigeyuki Murayama, Tetsuo Akimoto, Yusuke Demizu, Takashi Fukushima, Yuji Ishida, Yoshiko Oshiro, Haruko Numajiri, Hiroshi Fuji, Toshiyuki Okumura, Hiroki Shirato, Hideyuki Sakurai, Cancer Science, 108, 3, 444, 447, 01 Mar. 2017
Blackwell Publishing Ltd, English

Analysis of inter- and intra fractional partial bladder wall movement using implanted fiducial markers
Kentaro Nishioka, Shinichi Shimizu, Nobuo Shinohara, Yoichi M. Ito, Takashige Abe, Satoru Maruyama, Norio Katoh, Rumiko Kinoshita, Takayuki Hashimoto, Naoki Miyamoto, Rikiya Onimaru, Hiroki Shirato, RADIATION ONCOLOGY, 12, Mar. 2017
English

Tufted angiomaに対し放射線治療を行った1例
長江伸樹, 森崇, 木下留美子, 鬼丸力也, 白土博樹, 西村真智子, 畑中佳奈子, 木村鉄宣, Japanese Journal of Radiology, 35, Supplement, 4, 25 Feb. 2017
Japanese

頭蓋底腫瘍術後に強度変調放射線治療を行った2例
森崇, 宮本直樹, 鈴木隆介, 鬼丸力也, 白土博樹, Japanese Journal of Radiology, 35, Supplement, 4, 25 Feb. 2017
Japanese

下咽頭癌に対する強度変調放射線治療(IMRT)と強度変調陽子線治療(IMPT)の治療計画の比較
土屋和彦, 安田耕一, 原田八重, 鬼丸力也, 白土博樹, Japanese Journal of Radiology, 35, Supplement, 10, 10, 25 Feb. 2017
(公社)日本医学放射線学会, Japanese

画像診断に苦慮したHHV8-unrelated primary effusion lymphoma-like lymphomaの1例　　　　　　　　　　　　　　　
中川 純一, 加藤 扶美, 三村 理恵, 藪崎 哲史, 坂本 圭太, 真鍋 徳子, 工藤 與亮, 菅野 宏美, 松野 吉宏, 豊嶋 崇徳, 金谷 穣, 渡利 英道, 櫻木 範明, 白土 博樹, Japanese Journal of Radiology, 35, Suppl., 3, 3, Feb. 2017
(公社)日本医学放射線学会, Japanese

Phase I study of stereotactic body radiation therapy for peripheral T2NOM0 non-small cell lung cancer (JCOG0702): Results for the group with PTV >= 100 cc
Rikiya Onimaru, Hiroshi Onishi, Taro Shibata, Masahiro Hiraoka, Satoshi Ishikura, Katsuyuki Karasawa, Yukinori Matsuo, Masaki Kokubo, Yoshiyuki Shioyama, Haruo Matsushita, Yoshinori Ito, Hiroki Shirato, RADIOTHERAPY AND ONCOLOGY, 122, 2, 281, 285, Feb. 2017
English

Advanced diffusion models in head and neck squamous cell carcinoma patients: Goodness of fit, relationships among diffusion parameters and comparison with dynamic contrast-enhanced perfusion
Noriyuki Fujima, Tomohiro Sakashita, Akihiro Homma, Yukie Shimizu, Atsushi Yoshida, Taisuke Harada, Khin Khin Tha, Kohsuke Kudo, Hiroki Shirato, MAGNETIC RESONANCE IMAGING, 36, 16, 23, Feb. 2017
English

Impact of Real-Time Image Gating on Spot Scanning Proton Therapy for Lung Tumors: A Simulation Study
Takahiro Kanehira, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Yusuke Fujii, Takaaki Fujii, Yoichi M. Ito, Naoki Miyamoto, Tetsuya Inoue, Norio Katoh, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 97, 1, 173, 181, Jan. 2017
English

Breath-holding during the Calibration Scan Improves the Reproducibility of Parallel Transmission at 7T for Human Brain
Taisuke Harada, Kohsuke Kudo, Ikuko Uwano, Fumio Yamashita, Hiroyuki Kameda, Tsuyoshi Matsuda, Makoto Sasaki, Hiroki Shirato, MAGNETIC RESONANCE IN MEDICAL SCIENCES, 16, 1, 23, 31, 2017
English

Clinical outcomes of stage I and IIA non-small cell lung cancer patients treated with stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system
Norio Katoh, Itaru Soda, Hiroyasu Tamamura, Shotaro Takahashi, Yusuke Uchinami, Hiromichi Ishiyama, Kiyotaka Ota, Tetsuya Inoue, Rikiya Onimaru, Keiko Shibuya, Kazushige Hayakawa, Hiroki Shirato, RADIATION ONCOLOGY, 12, Jan. 2017
English

Mean kurtosis alterations of cerebral white matter in patients with schizophrenia revealed by diffusion kurtosis imaging.
Hisashi Narita, Khin K Tha, Naoki Hashimoto, Hiroyuki Hamaguchi, Shin Nakagawa, Hiroki Shirato, Ichiro Kusumi, Progress in neuro-psychopharmacology & biological psychiatry, 71, 169, 75, 03 Nov. 2016, [International Magazine]
English

Development of Patient-centered Navigation System of Cancer Diagnosis and Treatment
白土博樹, 安田耕一, 熊木康雄, 上杉正人, 医療情報学, 36, Supplement 1, 126‐127, 01 Nov. 2016
Japanese

気管内挿管下全身麻酔管理で陽子線治療を実施した小児がんの2症例(Proton beam therapy for pediatric cancer with endotracheal intubation under the general anesthesia: A report of two cases)
橋本 孝之, 敦賀 健吉, 小林 浩之, 井口 晶裕, 本多 昌平, 杉山 未奈子, 安田 耕一, 宮城 久之, 山口 秀, 藤田 憲明, 大島 淳二郎, 長 祐子, 鬼丸 力也, 清水 伸一, 寺坂 俊介, 森本 裕二, 白土 博樹, 日本小児血液・がん学会雑誌, 53, 4, 366, 366, Nov. 2016
(NPO)日本小児血液・がん学会, English

The reoxygenation of hypoxia and the reduction of glucose metabolism in head and neck cancer by fractionated radiotherapy with intensity-modulated radiation therapy
Shozo Okamoto, Tohru Shiga, Koichi Yasuda, Shiro Watanabe, Kenji Hirata, Ken-ichi Nishijima, Keiichi Magota, Katsuhiko Kasai, Rikiya Onimaru, Kazuhiko Tuchiya, Yuji Kuge, Hiroki Shirato, Nagara Tamaki, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 43, 12, 2147, 2154, Nov. 2016
English

Glucose Metabolism and Its Complicated Relationship with Tumor Growth and Perfusion in Head and Neck Squamous Cell Carcinoma
Noriyuki Fujima, Tomohiro Sakashita, Akihiro Homma, Kenji Hirata, Tohru Shiga, Kohsuke Kudo, Hiroki Shirato, PLOS ONE, 11, 11, Nov. 2016
English

A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-beta-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam
Kenichiro Maeda, Hironobu Yasui, Tohru Yamamori, Taeko Matsuura, Seishin Takao, Motofumi Suzuki, Akira Matsuda, Osamu Inanami, Hiroki Shirato, PLOS ONE, 11, 11, Nov. 2016
English

Feasibility Study of Using Dual-Energy Cone Beam Computed Tomography (DE-CBCT) in Proton Therapy Treatment Planning
H. Peng, T. Kanehira, S. Takao, T. Matsuura, K. Umegaki, H. Shirato, L. Xing, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 96, 2, E697, E697, Oct. 2016
English, Summary international conference

From Simulation Studies to Clinical Measurements: Challenges, Limitations, and Future Outlook in Proton Acoustic Range Verification
S. Yousefi, M. Ahmad, L. Xiang, Y. Chen, M. Zhang, S. Tang, W. Zou, K. Umegaki, H. Shirato, L. Xing, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 96, 2, E620, E621, Oct. 2016
English, Summary international conference

A Retrospective Multi-institutional Study of Proton Beam Therapy for Head and Neck Cancer With Non-Squamous Cell Histologies
T. Akimoto, S. Zenda, N. Nakamura, Y. Demizu, T. Okimoto, S. Murayama, M. Mizumoto, H. Sakurai, T. Nakamura, Y. Kikuchi, K. Yamamoto, H. Shirato, T. Onoe, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 96, 2, E337, E337, Oct. 2016
English, Summary international conference

Enabling Conventional Cone Beam Computed Tomography With the Capability of Dual Energy Imaging Using a Simple Add-on Beam Modifier
R. Vinke, S. Takao, K. Umegaki, H. Shirato, H. Peng, L. Xing, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 96, 2, E636, E636, Oct. 2016
English, Summary international conference

Analysis of Durations and Dose Rates for Treatment of Moving Liver Tumors Using Real-Time Image Gated Spot Scanning Proton Beam Therapy
S. Shimizu, N. Katoh, T. Hashimoto, K. Nishioka, T. Yoshimura, S. Takao, T. Matsuura, N. Miyamoto, K. Umegaki, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 96, 2, S211, S212, Oct. 2016
English, Summary international conference

Autonomous Quality Assurance for Spot-Scanning Proton Therapy and SRS/SBRT Using Radioluminescent Phantoms, Optical Imaging, and Machine Vision
C. H. Jenkins, Y. Yang, S. J. Yu, H. Yu, Y. Matsuzaki, T. Yoshimura, Y. Fujii, K. Umegaki, H. Shirato, L. Xing, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 96, 2, S170, S171, Oct. 2016
English, Summary international conference

Gold Nanoparticles With RGD Peptide in Radiation Therapy Suppress the Invasion Activity of Breast Cancer Cells
P. H. Wu, Y. Onodera, Y. Ichikawa, Y. Watanabe, W. Qian, T. Hashimoto, H. Shirato, J. M. Nam, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 96, 2, E574, E574, Oct. 2016
English, Summary international conference

Stereotactic Body Radiation Therapy Using a Real-time Tumor-Tracking Radiation Therapy System for Hepatocellular Carcinomas
Y. Uchinami, N. Katoh, D. Abo, K. Harada, T. Inoue, H. Taguchi, R. Onimaru, S. Shimizu, Y. Sakuhara, K. Ogawa, T. Kamiyama, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 96, 2, E155, E155, Oct. 2016
English, Summary international conference

Radiation Dose to Internal Mammary Lymph Node in Standard Tangential Breast Irradiation
R. Kinoshita, S. Shimizu, Y. Nishikawa, K. Nishioka, T. Hashimoto, R. Suzuki, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 96, 2, E17, E18, Oct. 2016
English, Summary international conference

非小細胞肺癌FMISO PET/CTにおける呼吸性移動距離と低酸素過小評価の検討　　　　　　　　　　　　　　　
渡邊 史郎, 平田 健司, 岡本 祥三, 志賀 哲, 井上 哲也, 孫田 惠一, 西嶋 剣一, 豊永 拓哉, 久下 裕司, 白土 博樹, 玉木 長良, 核医学, 53, Suppl., S317, S317, Oct. 2016
(一社)日本核医学会, Japanese

Effectiveness of superselective intra-arterial chemoradiotherapy targeting retropharyngeal lymph node metastasis
Takayoshi Suzuki, Tomohiro Sakashita, Akihiro Homma, Hiromitsu Hatakeyama, Satoshi Kano, Takatsugu Mizumachi, Daisuke Yoshida, Noriyuki Fujima, Rikiya Onimaru, Kazuhiko Tsuchiya, Koichi Yasuda, Hiroki Shirato, Fumiyuki Suzuki, Satoshi Fukuda, EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 273, 10, 3331, 3336, Oct. 2016
English

Spatial distributions of dose enhancement around a gold nanoparticle at several depths of proton Bragg peak
Jihun Kwon, Kenneth Sutherland, Takayuki Hashimoto, Hiroki Shirato, Hiroyuki Date, NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 384, 113, 120, Oct. 2016
English

Utility of noncontrast-enhanced time-resolved four-dimensional MR angiography with a vessel-selective technique for intracranial arteriovenous malformations
Noriyuki Fujima, Toshiya Osanai, Yukie Shimizu, Atsushi Yoshida, Taisuke Harada, Naoki Nakayama, Kohsuke Kudo, Kiyohiro Houkin, Hiroki Shirato, JOURNAL OF MAGNETIC RESONANCE IMAGING, 44, 4, 834, 845, Oct. 2016
English

NTCP modeling analysis of acute hematologic toxicity in whole pelvic radiation therapy for gynecologic malignancies - A dosimetric comparison of IMRT and spot-scanning proton therapy (SSPT)
Takaaki Yoshimura, Rumiko Kinoshita, Shunsuke Onodera, Chie Toramatsu, Ryusuke Suzuki, Yoichi M. Ito, Seishin Takao, Taeko Matsuura, Yuka Matsuzaki, Kikuo Umegaki, Hiroki Shirato, Shinichi Shimizu, PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 32, 9, 1095, 1102, Sep. 2016
English

Liver elasticity measurement before and after biliary drainage in patients with obstructive jaundice: a prospective cohort study (vol 16, 65, 2016)
Kimitoshi Kubo, Hiroshi Kawakami, Masaki Kuwatani, Mutsumi Nishida, Kazumichi Kawakubo, Shuhei Kawahata, Yoko Taya, Yoshimasa Kubota, Toraji Amano, Hiroki Shirato, Naoya Sakamoto, BMC GASTROENTEROLOGY, 16, Sep. 2016
English, Others

Effect of respiratory and cardiac gating on the major diffusion-imaging metrics.
Hiroyuki Hamaguchi, Khin Khin Tha, Hiroyuki Sugimori, Mitsuhiro Nakanishi, Shin Nakagawa, Taro Fujiwara, Hirokazu Yoshida, Sayaka Takamori, Hiroki Shirato, The neuroradiology journal, 29, 4, 254, 9, Aug. 2016, [International Magazine]
English

A Retrospective Study of G-Tube Use in Japanese Patients Treated with Concurrent Chemoradiotherapy for Hypopharyngeal Cancer
Akihiro Homma, Hiromitsu Hatakeyama, Takatsugu Mizumachi, Satoshi Kano, Tomohiro Sakashita, Rinnosuke Kuramoto, Yuji Nakamaru, Rikiya Onimaru, Kazuhiko Tsuchiya, Daisuke Yoshida, Koichi Yasuda, Hiroki Shirato, Satoshi Fukuda, PLOS ONE, 11, 8, Aug. 2016
English

Oligo-recurrence predicts favorable prognosis of brain-only oligometastases in patients with non-small cell lung cancer treated with stereotactic radiosurgery or stereotactic radiotherapy: a multi-institutional study of 61 subjects
Yuzuru Niibe, Tetsuo Nishimura, Tetsuya Inoue, Katsuyuki Karasawa, Yoshiyuki Shioyama, Keiichi Jingu, Hiroki Shirato, BMC CANCER, 16, Aug. 2016
English

Comparison of conventional ultrasonography and ultrasonography-computed tomography fusion imaging for target identification using digital/real hybrid phantoms: a preliminary study
Takeshi Soyama, Yusuke Sakuhara, Kohsuke Kudo, Daisuke Abo, Jeff Wang, Yoichi M. Ito, Yu Hasegawa, Hiroki Shirato, JOURNAL OF MEDICAL ULTRASONICS, 43, 3, 327, 335, Jul. 2016
English

Proton beam therapy for pediatric malignancies: a retrospective observational multicenter study in Japan
Masashi Mizumoto, Shigeyuki Murayama, Tetsuo Akimoto, Yusuke Demizu, Takashi Fukushima, Yuji Ishida, Yoshiko Oshiro, Haruko Numajiri, Hiroshi Fuji, Toshiyuki Okumura, Hiroki Shirato, Hideyuki Sakurai, CANCER MEDICINE, 5, 7, 1519, 1525, Jul. 2016
English

Optimization and evaluation of multiple gating beam delivery in a synchrotron-based proton beam scanning system using a real-time imaging technique
Takahiro Yamada, Naoki Miyamoto, Taeko Matsuura, Seishin Takao, Yusuke Fujii, Yuka Matsuzaki, Hidenori Koyano, Masumi Umezawa, Hideaki Nihongi, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki, PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 32, 7, 932, 937, Jul. 2016
English

Liver elasticity measurement before and after biliary drainage in patients with obstructive jaundice: a prospective cohort studya prospective cohort study
Kimitoshi Kubo, Hiroshi Kawakami, Masaki Kuwatani, Mutsumi Nishida, Kazumichi Kawakubo, Shuhei Kawahata, Yoko Taya, Yoshimasa Kubota, Toraji Amano, Hiroki Shirato, Naoya Sakamoto, BMC GASTROENTEROLOGY, 16, Jul. 2016
English

Enabling Conventional Cone Beam CT with the Capability of Dual Energy Imaging Using a Simple Add-On Beam Modifier
R. Vinke, S. Takao, K. Umegaki, H. Shirato, H. Peng, L. Xing, MEDICAL PHYSICS, 43, 6, 3457, 3457, Jun. 2016
English, Summary international conference

An Evaluation Method of Lifetime Attributable Risk for Comparing Between Proton Beam Therapy and Intensity Modulated X-Ray Therapy for Pediatric Cancer Patients by Averaging Four Dose-Response Models for Carcinoma Induction
M. Tamura, Y. Ito, H. Sakurai, M. Mizumoto, S. Kamizawa, S. Murayama, H. Yamashita, S. Takao, R. Suzuki, H. Shirato, MEDICAL PHYSICS, 43, 6, 3508, 3508, Jun. 2016
English, Summary international conference

Simulation Study of Real-Time-Image Gating On Spot Scanning Proton Therapy for Lung Tumors
T. Kanehira, T. Matsuura, S. Takao, Y. Matsuzaki, Y. Fujii, T. Fujii, N. Miyamoto, T. Inoue, N. Katoh, S. Shimizu, K. Umegaki, H. Shirato, MEDICAL PHYSICS, 43, 6, Jun. 2016
English, Summary international conference

Dose Enhancement by Gold Nanoparticles Around the Bragg Peak of Proton Beams
J. Kwon, K. Sutherland, T. Hashimoto, H. Peng, L. Xing, H. Shirato, H. Date, MEDICAL PHYSICS, 43, 6, 3787, +, Jun. 2016
English, Summary international conference

Feasibility Study of Using a Dual-Energy Cone Beam CT (DECBCT) in Proton Therapy Treatment Planning
H. Peng, T. Kanehira, S. Takao, T. Matsuura, K. Umegaki, H. Shirato, L. Xing, MEDICAL PHYSICS, 43, 6, 3457, 3458, Jun. 2016
English, Summary international conference

Dosimetric Comparison of Spot-Scanning Proton Therapy Techniques for Liver Tumors Close to the Skin Surface
S. Takao, T. Matsuura, Y. Matsuzaki, Y. Fujii, T. Fujii, N. Katoh, S. Shimizu, K. Umegaki, H. Shirato, MEDICAL PHYSICS, 43, 6, 3505, 3505, Jun. 2016
English, Summary international conference

Software Development for 4D-CBCT Research of Real-Time-Image Gated Spot Scanning Proton Therapy
T. Fujii, T. Matsuura, S. Takao, N. Miyamoto, Y. Matsuzaki, Y. Fujii, K. Umegaki, S. Shimizu, H. Shirato, MEDICAL PHYSICS, 43, 6, 3389, 3389, Jun. 2016
English, Summary international conference

No Increase in Biological Effectiveness Through Collimator Scattered Low Energy Protons
T. Matsuura, S. Takao, Y. Matsuzaki, Y. Fujii, T. Fujii, K. Maeda, H. Ueda, H. Koyano, K. Umegaki, H. Shirato, MEDICAL PHYSICS, 43, 6, 3492, 3492, Jun. 2016
English, Summary international conference

3T乳腺MRIにおける拡散尖度画像を用いた浸潤性乳癌の評価 バイオマーカーおよび腋窩リンパ節転移との比較　　　　　　　　　　　　　　　
加藤 扶美, 工藤 與亮, 藤原 太郎, Wang Jeff, 杉森 博行, 山下 啓子, 細田 充主, 真鍋 徳子, 三村 理恵, 白土 博樹, 日本乳癌学会総会プログラム抄録集, 24回, 250, 250, Jun. 2016
(一社)日本乳癌学会, Japanese

Evaluation of the relative biological effectiveness of spot-scanning proton irradiation in vitro
Kenichiro Maeda, Hironobu Yasui, Taeko Matsuura, Tohru Yamamori, Motofumi Suzuki, Masaki Nagane, Jin-Min Nam, Osamu Inanami, Hiroki Shirato, JOURNAL OF RADIATION RESEARCH, 57, 3, 307, 311, Jun. 2016
English

In vivo imaging of clock gene expression in multiple tissues of freely moving mice
Toshiyuki Hamada, Kenneth Sutherland, Masayori Ishikawa, Naoki Miyamoto, Sato Honma, Hiroki Shirato, Ken-ichi Honma, NATURE COMMUNICATIONS, 7, Jun. 2016
English

上咽頭癌再発例におけるFMISO‐PETと放射線治療に関する解析
安田耕一, 西川由記子, 岡本祥三, 伊藤陽一, 土屋和彦, 志賀哲, 鬼丸力也, 久下裕司, 玉木長良, 白土博樹, 頭けい部癌, 42, 2, 158, 158, 08 May 2016
日本頭頸部癌学会, Japanese

分子イメージングを用いた放射線治療
安田耕一, 安田耕一, 岡本祥三, 西川由記子, 伊藤陽一, 志賀哲, 井上哲也, 森崇, 豊永拓哉, 鬼丸力也, 渡邊史郎, 土屋和彦, 竹内渉, 加藤徳雄, 加藤徳雄, 久下裕司, 玉木長良, 白土博樹, 白土博樹, JSMI Report, 9, 2, 83, 83, 25 Apr. 2016
日本分子イメージング学会, Japanese

Comparison between borderline ovarian tumors and carcinomas using semi-automated histogram analysis of diffusion-weighted imaging: focusing on solid components.
Rie Mimura, Fumi Kato, Khin Khin Tha, Kohsuke Kudo, Yosuke Konno, Noriko Oyama-Manabe, Tatsuya Kato, Hidemichi Watari, Noriaki Sakuragi, Hiroki Shirato, Japanese journal of radiology, 34, 3, 229, 37, Mar. 2016, [Domestic magazines]
English

Treatment Time and Dose Rate Analysis for Respiratory Moving Liver Tumor Using Real-time-image Gated Spot Scanning Proton Beam Therapy System
SHIMIZU Shinichi, KATOH Norio, TAKAO Seishin, MATSUURA Taeko, MIYAMOTO Naoki, HASHIMOTO Takayuki, NISHIOKA Kentaro, YOSHIMURA Takaaki, UMEGAKI Kikuo, SHIRATO Hiroki, 日本医学放射線学会総会抄録集, 75th, S225, S225, 29 Feb. 2016
(公社)日本医学放射線学会, English

当院における下咽頭癌に対する強度変調放射線治療(IMRT)の初期経験
土屋和彦, 安田耕一, 原田八重, 鬼丸力也, 白土博樹, Japanese Journal of Radiology, 34, Supplement, 11, 11, 25 Feb. 2016
(公社)日本医学放射線学会, Japanese

3T乳腺MRIにおける拡散尖度画像の検討　　　　　　　　　　　　　　　
加藤 扶美, 工藤 與亮, 三村 理恵, 藪崎 哲史, 坂本 圭太, 宮本 憲幸, 真鍋 徳子, 藤原 太郎, 杉森 博行, 山下 啓子, 細田 充主, Wang Jeff, 白土 博樹, Japanese Journal of Radiology, 34, Suppl., 13, 13, Feb. 2016
(公社)日本医学放射線学会, Japanese

Development and evaluation of a short-range applicator for treating superficial moving tumors with respiratory-gated spot-scanning proton therapy using real-time image guidance
Taeko Matsuura, Yusuke Fujii, Seishin Takao, Takahiro Yamada, Yuka Matsuzaki, Naoki Miyamoto, Taisuke Takayanagi, Shinichiro Fujitaka, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki, PHYSICS IN MEDICINE AND BIOLOGY, 61, 4, 1515, 1531, Feb. 2016
English

Prognostic Imaging Biomarkers in Glioblastoma: Development and Independent Validation on the Basis of Multiregion and Quantitative Analysis of MR Images
Yi Cui, Khin Khin Tha, Shunsuke Terasaka, Shigeru Yamaguchi, Jeff Wang, Kohsuke Kudo, Lei Xing, Hiroki Shirato, Ruijiang Li, RADIOLOGY, 278, 2, 546, 553, Feb. 2016
English

Usefulness of Pseudocontinuous Arterial Spin-Labeling for the Assessment of Patients with Head and Neck Squamous Cell Carcinoma by Measuring Tumor Blood Flow in the Pretreatment and Early Treatment Period
N. Fujima, D. Yoshida, T. Sakashita, A. Homma, A. Tsukahara, K. K. Tha, K. Kudo, H. Shirato, AMERICAN JOURNAL OF NEURORADIOLOGY, 37, 2, 342, 348, Feb. 2016
English

Evaluation of the motion of lung tumors during stereotactic body radiation therapy (SBRT) with four-dimensional computed tomography (4DCT) using real-time tumor-tracking radiotherapy system (RTRT)
Keiichi Harada, Norio Katoh, Ryusuke Suzuki, Yoichi M. Ito, Shinichi Shimizu, Rikiya Onimaru, Tetsuya Inoue, Naoki Miyamoto, Hiroki Shirato, PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 32, 2, 305, 311, Feb. 2016
English

非小細胞肺癌FMISO PET/CTにおける呼吸性移動距離と低酸素過小評価の検討
渡邊史郎, 平田健司, 岡本祥三, 志賀哲, 井上哲也, 孫田惠一, 西嶋剣一, 豊永和哉, 久下裕司, 白土博樹, 玉木長良, 核医学(Web), 53, Supplement, 1271(J‐STAGE), 2016
Japanese

がん細胞における小胞輸送経路を介したミトコンドリア分布制御と活性酸素および放射線への耐性
小野寺康仁, 南ジンミン, 白土博樹, 佐邊壽孝, 日本放射線影響学会大会抄録(Web), 59th, ROMBUNNO.W12‐1 (WEB ONLY), 26, 2016
(一社)日本放射線影響学会, Japanese

Intrafractional Baseline Shift or Drift of Lung Tumor Motion During Gated Radiation Therapy With a Real-Time Tumor-Tracking System
Seishin Takao, Naoki Miyamoto, Taeko Matsuura, Rikiya Onimaru, Norio Katoh, Tetsuya Inoue, Kenneth Lee Sutherland, Ryusuke Suzuki, Hiroki Shirato, Shinichi Shimizu, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 94, 1, 172, 180, Jan. 2016
English

Indications for superselective intra-arterial cisplatin infusion and concomitant radiotherapy in cases of hypopharyngeal cancer
Jun Furusawa, Akihiro Homma, Rikiya Onimaru, Tomohiro Sakashita, Daisuke Yoshida, Hiromitsu Hatakeyama, Takatsugu Mizumachi, Satoshi Kano, Kazuhiko Tsuchiya, Koichi Yasuda, Hiroki Shirato, Satoshi Fukuda, Journal of Otolaryngology of Japan, 119, 5, 782, 783, 2016

Evaluation of diagnostic accuracy in CT perfusion analysis in moyamoya disease
Takashi Ohno, Kohsuke Kudo, Greg Zaharchuk, Noriyuki Fujima, Hiroki Shirato, JAPANESE JOURNAL OF RADIOLOGY, 34, 1, 28, 34, Jan. 2016
English

Differences in morphological features and minimum apparent diffusion coefficient values among breast cancer subtypes using 3-tesla MRI
Fumi Kato, Kohsuke Kudo, Hiroko Yamashita, Jeff Wang, Mitsuchika Hosoda, Kanako C. Hatanaka, Rie Mimura, Noriko Oyama-Manabe, Hiroki Shirato, EUROPEAN JOURNAL OF RADIOLOGY, 85, 1, 96, 102, Jan. 2016
English

Clinical outcomes of weekly cisplatin chemoradiotherapy for patients with pyriform sinus cancer
Tomohiro Sakashita, Akihiro Homma, Hiromitsu Hatakeyama, Jun Furusawa, Satoshi Kano, Takatsugu Mizumachi, Satoshi Iizuka, Rikiya Onimaru, Kazuhiko Tsuchiya, Koichi Yasuda, Hiroki Shirato, Satoshi Fukuda, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 20, 6, 1081, 1085, Dec. 2015
English

Three-dimensional conformal fractionated radiotherapy for spinal schwannoma with a paravertebral or an intraosseous component
Rikiya Onimaru, Kazutoshi Hida, Naoki Takeda, Shunsuke Onodera, Yukiko Nishikawa, Takashi Mori, Hiroki Shirato, JAPANESE JOURNAL OF RADIOLOGY, 33, 12, 757, 763, Dec. 2015
English

Indications for superselective intra-arterial cisplatin infusion and concomitant radiotherapy in cases of hypopharyngeal cancer
Jun Furusawa, Akihiro Homma, Rikiya Onimaru, Tomohiro Sakashita, Daisuke Yoshida, Hiromitsu Hatakeyama, Takatsugu Mizumachi, Satoshi Kano, Kazuhiko Tsuchiya, Koichi Yasuda, Hiroki Shirato, Satoshi Fukuda, AURIS NASUS LARYNX, 42, 6, 443, 448, Dec. 2015
English

Radiomic Analysis of FDG-PET Identifies Novel Prognostic Imaging Biomarkers in Locally Advanced Pancreatic Cancer Patients Treated With SBRT
Y. Cui, J. Song, E. Pollom, H. Shirato, D. T. Chang, A. C. Koong, R. Li, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93, 3, S4, S5, Nov. 2015
English, Summary international conference

Respiration-gated F-18-fluoromisonidazole PET/CT for Stage I Non-Small Cell Lung Cancer Treated by Stereotactic Body Radiation Therapy
T. Inoue, S. Okamoto, S. Watanabe, K. Yasuda, N. Katoh, K. Harada, R. Onimaru, T. Shiga, N. Tamaki, Y. Kuge, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93, 3, E390, E391, Nov. 2015
English, Summary international conference

Induction chemotherapy in locally advanced head and neck cancer
Yasushi Shimizu, Jun Taguchi, Ichiro Kinoshita, Kazuhiko Tsuchiya, Hiroki Shirato, Akihiro Homma, Satoshi Fukuda, Hirotoshi Akita, ANNALS OF ONCOLOGY, 26, 33, 33, Nov. 2015
English, Summary international conference

Radiotherapy : characteristics of particle therapy and its perspective
Hiroki Shirato, ANNALS OF ONCOLOGY, 26, 65, 65, Nov. 2015
English, Summary international conference

Target Residual Motion During Beam Delivery in Gated Irradiation Using Real Time Tumor Tracking Radiation Therapy System: Analysis of Simultaneous Motion of Multiple Internal Fiducial Markers
N. Miyamoto, M. Ishikawa, R. Suzuki, A. Makinaga, T. Matsuura, S. Takao, Y. Matsuzaki, T. Inoue, N. Katoh, S. Shimizu, R. Onimaru, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93, 3, E554, E554, Nov. 2015
English, Summary international conference

NTCP Modeling Analysis of Acute Hematologic Toxicity in Whole-Pelvic Radiation Therapy for Gynecologic Malignancies: A Dosimetric Comparison of IMRT and Spot-Scanning Proton Therapy
T. Yoshimura, R. Kinoshita, S. Onodera, C. Toramatsu, R. Suzuki, Y. M. Ito, S. Takao, T. Matsuura, Y. Matsuzaki, S. Shimizu, K. Umegaki, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93, 3, E254, E254, Nov. 2015
English, Summary international conference

Locally advanced head and neck squamous cell carcinomas treated with TPF(docetaxel, cisplatin, 5-FU) induction chemotherapy
Jun Taguchi, Yasushi Shimizu, Ichiro Kinoshita, Rio Honma, Satoshi Takeuchi, Kazuhiko Tsuchiya, Hiroki Shirato, Akihiro Homma, Satoshi Fukuda, Hirotoshi Akita, ANNALS OF ONCOLOGY, 26, 90, 90, Nov. 2015
English, Summary international conference

Development of a Real-Time Image Gated Proton Beam Therapy (RGPT) System and Its Initial Clinical Application to Respiratory Moving Liver Tumors
S. Shimizu, N. Katoh, S. Takao, T. Matsuura, N. Miyamoto, T. Hashimoto, K. Nishioka, T. Yoshimura, Y. Matsuzaki, R. Kinoshita, Y. Nishikawa, R. Onimaru, K. Umegaki, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93, 3, S42, S42, Nov. 2015
English, Summary international conference

The Voxel-based Analysis of FMISO-PET Image in Patients With Local Recurrence of Nasopharyngeal Carcinoma
Y. Nishikawa, K. Yasuda, S. Okamoto, Y. M. Ito, T. Mori, R. Onimaru, T. Shiga, K. Tsuchiya, S. Watanabe, W. Takeuchi, N. Katoh, Y. Kuge, N. Tamaki, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93, 3, E337, E337, Nov. 2015
English, Summary international conference

Dose-Escalation Study of Stereotactic Body Radiation Therapy (SBRT) for Peripheral T2N0M0 Non-Small Cell Lung Cancer (NSCLC) With PTV >= 100 cm(3): Japan Clinical Oncology Group Study (JCOG0702)
H. Onishi, R. Onimaru, T. Shibata, M. Hiraoka, S. Ishikura, K. Karasawa, Y. Matsuo, M. Kokubo, Y. Shioyama, H. Matsushita, Y. Ito, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93, 3, S102, S102, Nov. 2015
English, Summary international conference

Involvement of UTR-dependent gene expression in the maintenance of cancer stem cell like phenotypes
Motoaki Yasuda, Tomoyuki Hatanaka, Hiroki Shirato, Takeshi Nishioka, Oncology Letters, 10, 5, 3171, 3176, Nov. 2015
English