Aug. 2023, 北海道大学, 北海道大学全学教育科目授業アンケートにおけるエクセレント・ティーチャーズ　　　　　　　　　　　　　　　

Aug. 2022, 北海道大学, 北海道大学全学教育科目授業アンケートにおけるエクセレント・ティーチャーズ　　　　　　　　　　　　　　　

Aug. 2021, 北海道大学, 全学教育科目に係る授業アンケートにおけるエクセレントティーチャーズ　　　　　　　　　　　　　　　

Oct. 2019, 日本神経精神薬理学会, Neuropsychopharmacology Reports (NPPR) Topic Award 2019　　　　　　　　　　　　　　　
山仲勇二郎

Oct. 2019, 日本神経精神薬理学会, Neuropsychopharmacology Reports (NPPR) Article Award 2019　　　　　　　　　　　　　　　
山仲勇二郎

Nov. 2017, 国立研究開発法人 科学技術振興機構（JST), COI2021 表彰特別賞　　　　　　　　　　　　　　　
山仲勇二郎

Jul. 2015, 北海道大学医学部医学科, 平成26年度エクセレント・ティーチャー(優秀賞）　　　　　　　　　　　　　　　
山仲勇二郎

Nov. 2014, 日本時間生物学学会, 日本時間生物学会学術奨励賞　　　　　　　　　　　　　　　
山仲勇二郎

Jul. 2014, 北海道大学医学部医学科, 平成25年度優秀教員賞　　　　　　　　　　　　　　　
山仲勇二郎

Nov. 2013, 第20回日本時間生物学会学術大会優秀ポスター賞　　　　　　　　　　　　　　　
山仲勇二郎

Mar. 2012, 日本生理学会環境生理学グループ久野寧記念賞　　　　　　　　　　　　　　　
山仲勇二郎

Two oscillatory components detected by forced splitting of the sleep-wake cycle in humans.
Satoko Hashimoto, Takuro Endo, Sato Honma, Yujiro Yamanaka, Ken-Ichi Honma
American journal of physiology. Regulatory, integrative and comparative physiology, 326, 1, R19-R28, 01 Jan. 2024, [International Magazine]
English, Scientific journal, The sleep-wake cycle of human subjects was artificially split into two episodes by imposing an 8-h light and 4-h dark cycle (LD 8:4) twice a day for 7 days, which was followed by a 3-day free-running session. Sleep was permitted only in the dark period. The subjects in the ordinary group were exposed to ordinary light (ca. 500 lx) in the 8-h light period, and those in the bright light group to bright (ca. 5,000 lx) and ordinary light alternatively with bright light after the first dark period (2400-400). Split sleeps persisted in the free-running session with the major episode around the first dark period and the minor episode around the second dark period. By contrast, circadian melatonin rhythm in the free-running session significantly phase delayed in the ordinary light group, but phase advanced in the bright light group, keeping the melatonin rhythm unsplit. The length of nocturnal melatonin secretion (NMS) was significantly shortened in the bright light group. Interestingly, the falling phase of NMS advanced significantly further than the rising phase. Such a difference was not detected in the ordinary light group. Similar differences were observed in the body temperature rhythm. These findings indicated oscillatory mechanisms underlying split sleeps distinct from the circadian pacemaker and suggested an involvement of different circadian oscillators in the rising and falling phases of NMS, which is consistent with the dual oscillator model proposed for the circadian system of nocturnal rodents.NEW & NOTEWORTHY The present study demonstrated that human sleep was separated into two essentially identical components, which persisted under constant conditions, suggesting circadian oscillator underlying split-sleep episodes. The study also indicated differential light sensitivities in the rising and falling phases of circadian melatonin rhythm, indicating the involvement of two different oscillators. These results consisted of the evening and morning dual-oscillator hypothesis for the circadian pacemaker and the hierarchical model for the pacemaker and sleep-wake cycle.

Differential responses to artificial photoperiods of the rising and falling phases of human melatonin rhythm are consistent with a dual oscillator hypothesis.
Satoko Hashimoto, Takuro Endo, Sato Honma, Yujiro Yamanaka, Ken-Ichi Honma
American journal of physiology. Regulatory, integrative and comparative physiology, 325, 5, R619-R628, 01 Nov. 2023, [International Magazine]
English, Scientific journal, Circadian rhythms and sleep-wake cycles were measured in volunteers staying singly in temporal isolation unit where they were exposed to artificial short and long light-dark (LD) cycles for 7 days. The long day consisted of 16-h light and 8-h dark (LD 16:8) and the short day consisted of 8-h light and 16-h dark (LD 8:16). During the light period, bright light of approximately 5,000 lux was given from the ceiling and during the dark period there was no illumination. Sleep was monitored by bed sensors, wrist actiwatch, and polysomnography (PSG) on the first and last nights of the schedule. Sleep length was significantly longer under LD 8:16 than under LD 16:8 and the sleep quality estimated by PSG was worse under LD 8:16 than under LD 16:8, which were comparable to natural seasonality in sleep. The circadian rhythm in plasma melatonin was measured in dim light (10 lux) before and after the LD exposures. The nocturnal melatonin secretion (NMS) was significantly longer after LD 8:16 than after LD 16:8 due to differential phase shifts of the rising and falling phases of NMS. After LD 8:16, the falling phase was much advanced than the rising phase, whereas after LD 16:8 the rising phase was much delayed than the falling phase, resulting in the NMS compression. These results indicate that the light sensitivity in terms of phase shifting is different in the two circadian phases, supporting a dual oscillator hypothesis with different phase-response curves for light in the human circadian system.NEW & NOTEWORTHY The present study demonstrated differential light responsiveness of the rising and falling phases of nocturnal melatonin secretion in human subjects exposed to artificial long (LD 16:8) and short days (LD 8:16) and suggested the involvement of different oscillators under these phases. The findings well mimicked the seasonality of the circadian rhythms in nature and consisted with the evening/morning dual oscillator hypothesis proposed originally for nocturnal rodents, providing a new concept for the human circadian system.

Nonphotic entrainment of central and peripheral circadian clocks in mice by scheduled voluntary exercise under constant darkness.
Ren Y Sato, Yujiro Yamanaka
American journal of physiology. Regulatory, integrative and comparative physiology, 20 Feb. 2023, [International Magazine]
English, Scientific journal, In mammals, the central circadian pacemaker in the suprachiasmatic nucleus (SCN) entrains to an environmental light-dark (LD) cycle and organizes the temporal order of circadian rhythms in physiology and behavior. Previously, some studies have demonstrated that scheduled exercise could entrain the free-running behavior rhythm in nocturnal rodents. However, it remains unknown whether entrainment by scheduled exercise alters the internal temporal order of the behavioral circadian rhythms or clock gene expression in the SCN, extra-SCN brain regions, and peripheral organs when mice are entrained to the scheduled exercise under constant darkness (DD). In the present study, we examined circadian rhythms in locomotor activity and Per1-luc rhythms in the SCN, arcuate nucleus (ARC), liver, and skeletal muscle of mice entrained to an LD, mice free-running under DD and mice entrained to daily exposure to a new cage with a running wheel (NCRW) under DD. All mice showed a steady-state entrainment of behavioral circadian rhythms to NCRW exposure under DD in parallel with shortening the alpha when compared to that under DD. The temporal order of behavioral circadian rhythms and the Per1-luc rhythms in the SCN and peripheral tissues but not in the ARC were maintained in the mice entrained to the NCRW and LD cycles; in contrast, the temporal order was altered in the mice under DD. The present findings reveal that the SCN entrains to daily exercise, and daily exercise reorganizes the internal temporal order of behavioral circadian rhythms and clock gene expression in the SCN and peripheral tissues.

[Impacts of mastication frequency on circadian rhythm of glucose metabolism].
Yujiro Yamanaka
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 158, 2, 165, 168, 2023, [Domestic magazines]
Japanese, Scientific journal, Postprandial glucose concentration is dependent on the time of day and its concentration in the morning is lower than in the evening. The circadian rhythm of glucose metabolism is regulated by the central circadian pacemaker in the suprachiasmatic nucleus (SCN). Both the SCN circadian clock and the pancreatic clock play important role in generating and maintaining the circadian rhythm of glucose metabolism. Also, short sleep duration and circadian misalignment are closely associated with a decrease in insulin sensitivity and an increase in type2 diabetes. Increased frequency of mastication and/or thorough chewing has been reported to alter the secretion of hormones related to appetite and energy metabolism. Furthermore, we have reported that the effect of mastication on postprandial glucose metabolism is dependent on the time of day and frequency of mastication. Morning mastication but not evening decreases postprandial blood glucose concentrations and increases insulin secretion at 30 min and so-called the insulinogenic index as a marker of early-phase β-cell function. This novel finding may aid in reducing the incidence of obesity and type 2 diabetes mellitus. This review covers the basic concept of the mammalian human circadian system, the underlying mechanism causing phase adjustment of the circadian rhythms in the SCN and peripheral organs, and the effect of eating behavior (e.g., chewing frequency) on the circadian rhythm of glucose metabolism.

Time of Day of Vaccination Does Not Associate With SARS-CoV-2 Antibody Titer Following First Dose of mRNA COVID-19 Vaccine.
Yujiro Yamanaka, Isao Yokota, Atsushi Yasumoto, Eriko Morishita, Hisanori Horiuchi
Journal of biological rhythms, 37, 6, 7487304221124661, 7487304221124661, 26 Sep. 2022, [International Magazine]
English, The immune system exhibits circadian rhythms, and its response to viral infection is influenced by the circadian clock system. Previous studies have reported associations between the time of day of vaccination against COVID-19 and production of anti-SARS-CoV-2 antibody titer. We examined the effect of vaccination time of day on anti-SARS-CoV-2 antibody titer after the first dose of vaccination with the mRNA-1273 (Moderna) COVID-19 vaccine in an adult population. A total of 332 Japanese adults participated in the present study. All participants were not infected with SARS-CoV-2 and had already received the first dose of mRNA-1273 2 to 4 weeks prior to participating in the study. The participants were asked to provide basic demographic characteristics (age, sex, medical history, allergy, medication, and mean sleep duration), the number of days after the first dose of vaccination, and the time of day of vaccination. Blood was collected from the participants, and SARS-CoV-2 antibody titers were measured. Ordinary least square regression was used for assessing the relationship between basic demographic characteristics, number of days after vaccination, time of day of vaccination, and the log10-transformed normalized antibody titer. The least square mean of antibody titers was not associated with the vaccination time and sleep durations. The least square means of antibody titers was associated with age; the antibody titers decreased in people aged 50 to 59 years and 60 to 64 years. The present findings demonstrate that the vaccination time with mRNA-1273 was not associated with the SARS-CoV-2 antibody titer in an adult population, suggesting that these results do not support restricting vaccination to a particular time of day. The present findings may be useful in optimizing SARS-CoV-2 vaccination strategies.

Correction to: Effects of Lactococcus lactis subsp. cremoris YRC3780 daily intake on the HPA axis response to acute psychological stress in healthy Japanese men.
Noriko Matsuura, Hidemasa Motoshima, Kenji Uchida, Yujiro Yamanaka
European journal of clinical nutrition, 10 May 2022, [International Magazine]
English

A fixed single meal in the subjective day prevents free-running of the human sleep-wake cycle but not of the circadian pacemaker under temporal isolation.
Yujiro Yamanaka, Satoko Hashimoto, Aya Honma, Sato Honma, Ken-Ichi Honma
American journal of physiology. Regulatory, integrative and comparative physiology, 26 Apr. 2022, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal, Effects of a fixed single meal per day were examined on the circadian pacemaker and sleep-wake cycle in subjects under temporal isolation. When the time of single meal was allowed to take at any time of day (Ad-lib meal), the sleep-wake cycle as well as the circadian rhythms in plasma melatonin, cortisol and core body temperature were significantly phase-delayed in 8 days. On the other hand, when the time of meal was fixed at 1800 h in local time (RF meal), the phase-shift of sleep-wake cycle was not significant, while those of the circadian rhythms were significant. The differential effects of a fixed single meal schedule were confirmed in most individual subjects. There was no evidence for the prefeeding increase in plasma cortisol and leptin levels under the fixed single meal schedule. The plasma ghrelin level was apparently high before meal in both Ad-lib and RF meal groups, which was, however, likely sculptured by a non-specific prandial drop and gradual increase after meal intake. Single meal augmented the prandial increase of plasma insulin levels by 4-5 times. These findings indicate that a single meal at fixed time of day during the subjective day failed to prevent the human circadian pacemaker but prevented the sleep-wake cycle to free-run at least 8 days under temporal isolation, suggesting that meal time was a potent non-photic time cue for the human sleep-wake cycle.

Effects of different light incident angles via a head-mounted device on the magnitude of nocturnal melatonin suppression in healthy young subjects　　　　　　　　　　　　　　　
Naoko Kubota, Yusuke Tamori, Kenkichi Baba, Yujiro Yamanaka
Sleep and Biological Rhythms, 21 Jan. 2022, [Peer-reviewed], [Corresponding author]
English, Scientific journal

Effects of Lactococcus lactis subsp. cremoris YRC3780 daily intake on the HPA axis response to acute psychological stress in healthy Japanese men
Noriko Matsuura, Hidemasa Motoshima, Kenji Uchida, Yujiro Yamanaka
European Journal of Clinical Nutrition, Springer Science and Business Media LLC, 04 Aug. 2021, [Peer-reviewed], [Last author, Corresponding author]
Scientific journal,

Lactococcus lactis subsp. cremoris (YRC3780), which is isolated from kefir, has been associated with anti-allergic effects in humans. However, it remains unknown whether daily intake of YRC3780 attenuates the response to psychological stress in humans in parallel with changes to the gut microbiome. We examined the fundamental role of YRC3780 in the gut microbiome, stress response, sleep, and mental health in humans.




Effects of daily intake of YRC3780 on the hypothalamic-pituitary-adrenal (HPA) axis response to acute psychological stress were investigated in a double-blind, placebo-controlled clinical trial involving 27 healthy young men (mean age and body mass index: 23.5 years and 21.5 kg/m²) who were randomly assigned to placebo (n = 13) or YRC3780 (n = 14) groups. The HPA axis response to acute psychological stress, the diurnal rhythm of HPA axis activity, and gut microbiome were assessed and compared between the two groups.




The results showed that daily intake of YRC3780 significantly lowered morning salivary cortisol levels compared with placebo. In addition, salivary cortisol levels following a social stress test significantly decreased +40 min after beginning the TSST in the YRC3780-treated group compared to placebo. There were no significant differences between the two groups in terms of actigraphy-based sleep quality, but the subjective sleep quality and mental health were significantly improved in the YRC3780-treated group compared to placebo.




Our study suggests that daily intake of YRC3780 improves the HPA axis response to acute psychological stress, which might be associated with a decrease in morning cortisol levels.

Basic concepts and unique features of human circadian rhythms: implications for human health.
Yujiro Yamanaka
Nutrition reviews, 78, Supplement_3, 91, 96, 01 Dec. 2020, [Peer-reviewed], [Invited], [Lead author, Corresponding author], [International Magazine]
English, Scientific journal, Most physiological functions and behaviors exhibit a robust approximately 24-hour rhythmicity (circadian rhythm) in the real world. These rhythms persist under constant conditions, but the period is slightly longer than 24 hours, suggesting that circadian rhythms are endogenously driven by an internal, self-sustained oscillator. In mammals, including humans, the central circadian pacemaker is located in the hypothalamic suprachiasmatic nucleus. The primary zeitgeber for this pacemaker is bright sunlight, but nonphotic time cues also affect circadian rhythms. The human circadian system uniquely exhibits spontaneous internal desynchronization between the sleep-wake cycle and core body temperature rhythm under constant conditions and partial entrainment of the sleep-wake cycle in response to nonphotic time cues. Experimental and clinical studies of human circadian rhythms must take into account these unique features. This review covers the basic concepts and unique features of the human circadian system, the mechanisms underlying phase adjustment of the circadian rhythms by light and nonphotic time cues (eg, physical exercise), and the effects of eating behavior (eg, chewing frequency) on the circadian rhythm of glucose metabolism.

Morning Mastication Enhances Postprandial Glucose Metabolism in Healthy Young Subjects
Arisa Sato, Yoshinori Ohtsuka, Yujiro Yamanaka
Tohoku Journal of Experimental Medicine, 249, 3, 193, 201, Nov. 2019, [Peer-reviewed], [Last author, Corresponding author]
English, Scientific journal, 13081245

Hypothalamic-pituitary-adrenal axis differentially responses to morning and evening psychological stress in healthy subjects.
Yamanaka Y, Motoshima H, Uchida K
Neuropsychopharmacology reports, 39, 1, 41, 47, Mar. 2019, [Peer-reviewed], [Lead author, Corresponding author]

Cryptochrome deficiency enhances transcription but reduces protein levels of pineal Aanat
Yamanaka Y, Yamada Y, Honma KI, Honma S
Journal of molecular endocrinology, 61, 4, 219, 229, Oct. 2018, [Peer-reviewed], [Lead author]

Two Coupled Circadian Oscillators Are Involved in Nonphotic Acceleration of Reentrainment to Shifted Light Cycles in Mice.
Yamanaka Y, Honma S, Honma KI
Journal of biological rhythms, 33, 6, 748730418796300, 625, Sep. 2018, [Peer-reviewed], [Lead author]

Phase-adjustment of human circadian rhythms by light and physical exercise.
Yamanaka Y, Waterhouse J
The Journal of Physical Fitness and Sports Medicine, 5, 4, 287, 299, 03 Oct. 2016, [Peer-reviewed], [Invited], [Lead author, Corresponding author]

Mistimed wheel running interferes with re-entrainment of circadian Per1 rhythms in the mouse skeletal muscle and lung
Yujiro Yamanaka, Sato Honma, Ken-ichi Honma
GENES TO CELLS, 21, 3, 264, 274, WILEY-BLACKWELL, Mar. 2016, [Peer-reviewed], [Lead author]
English, Scientific journal, Previously, we showed the acceleration of re-entrainment to 8-h phase-advanced light/dark cycles (LD) in the circadian Per1 expression rhythms of the mouse lung and skeletal muscle by 3-h wheel running (WR) at the beginning of shifted dark phase. In the present study, the effects of WR at the end of shifted dark phase were examined on the re-entrainment in mice. LD was advanced by shortening and was delayed by lengthening the first light period in the phase-advance and phase-delay protocol, respectively. Shifted LD was continued for 4days, which was followed by constant darkness (DD). Per1 expression was measured in the cultured tissues obtained on the first day of DD from mice carrying a bioluminescence reporter of Per1 expression. In the phase-advance protocol, re-entrainment was not influenced by WR in any circadian rhythm examined. In the phase-delay protocol, re-entrainment of the circadian locomotor rhythm was not affected by WR. However, re-entrainment of circadian Per1 rhythm was significantly decelerated in the skeletal muscle and lung. These findings indicate that the effects of WR on re-entrainment depend on the time of day and the peripheral tissues. Mistimed WR interferes with re-entrainment of circadian rhythms in the lung and skeletal muscle.

Morning and evening physical exercise differentially regulate the autonomic nervous system during nocturnal sleep in humans
Yujiro Yamanaka, Satoko Hashimoto, Nana N. Takasu, Yusuke Tanahashi, Shin-ya Nishide, Sato Honma, Ken-ichi Honma
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 309, 9, R1112, R1121, AMER PHYSIOLOGICAL SOC, Nov. 2015, [Peer-reviewed], [Lead author]
English, Scientific journal, Effects of daily physical exercise in the morning or in the evening were examined on circadian rhythms in plasma melatonin and core body temperature of healthy young males who stayed in an experimental facility for 7 days under dim light conditions (< 10 lux). Sleep polysomnogram (PSG) and heart rate variability (HRV) were also measured. Subjects performed 2-h intermittent physical exercise with a bicycle ergometer at ZT3 or at ZT10 for four consecutive days, where zeitgeber time 0 (ZT0) was the time of wake-up. The rising phase of plasma melatonin rhythm was delayed by 1.1 h without exercise. Phase-delay shifts of a similar extent were detected by morning and evening exercise. But the falling phase shifted only after evening exercise by 1.0 h. The sleep PSG did not change after morning exercise, while Stage 1 + 2 sleep significantly decreased by 13.0% without exercise, and RE sleep decreased by 10.5% after evening exercise. The nocturnal decline of rectal temperature was attenuated by evening exercise, but not by morning exercise. HRV during sleep changed differentially. Very low frequency (VLF) waves increased without exercise. VLF, low frequency (LF), and high frequency (HF) waves increased after morning exercise, whereas HR increased after evening exercise. Morning exercise eventually enhanced the parasympathetic activity, as indicated by HRV, while evening exercise activated the sympathetic activity, as indicated by increase in heart rate in the following nocturnal sleep. These findings indicated differential effects of morning and evening exercise on the circadian melatonin rhythm, PSG, and HRV.

食事時刻がヒトの生体リズムおよびエネルギー代謝調節に与える影響
山仲 勇二郎, 橋本 聡子, 山田 淑子, 本間 研一
デサントスポーツ科学, 36, 50, 60, (公財)石本記念デサントスポーツ科学振興財団, Jun. 2015, [Peer-reviewed], [Lead author]
Japanese, 本研究では,健康成人男性を対象に外界の昼夜変化や時刻情報を排除した時間隔離実験室内でヒトの生物時計機構に他のほ乳類で報告されている食事時刻を予知する食事時刻依存性概日リズムが出現するか,規則的な食事スケジュールにヒトの生物時計が同調するかを検証した.実験では,健常成人男性が15日間隔離実験室に滞在し,1日1食の食事スケジュールを8日間おこなった.実験室内の光照度は200lux未満の低照度に設定した.その際,食事時刻を一定時刻に固定した群(食事固定群,5名)と被験者自身が決める群(食事自由群,5名)の2群にわけ,1日1食の食事スケジュールに対する睡眠覚醒リズム,血中ホルモンリズムの変化を調べた.その結果,食事固定群,食事自由群共に,今回調べたメラトニン,コルチゾル,インスリン,グレリン,レプチンには,食事前のホルモン濃度の上昇はみられなかった.睡眠覚醒リズムは両実験群共に実験期間中に有意な位相変化は認められず,24時間周期を示した.血中メラトニンのリズムは,1日1食の食事スケジュール後では両群共に有意に位相後退した.以上より,本実験条件ではヒトの食事時刻依存性概日リズムは発現しないこと,1日1回の食事スケジュールは睡眠覚醒リズムの同調因子として作用するが,生物時計には影響しないことが示唆された.(著者抄録)

Differential regulation of circadian melatonin rhythm and sleep-wake cycle by bright lights and nonphotic time cues in humans
Yujiro Yamanaka, Satoko Hashimoto, Satoru Masubuchi, Akiyo Natsubori, Shin-ya Nishide, Sato Honma, Ken-ichi Honma
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 307, 5, R546, R557, AMER PHYSIOLOGICAL SOC, Sep. 2014, [Peer-reviewed]
English, Scientific journal, Our previous study demonstrated that physical exercise under dim lights (<10 lux) accelerated reentrainment of the sleep-wake cycle but not the circadian melatonin rhythm to an 8-h phase-advanced sleep schedule, indicating differential effects of physical exercise on the human circadian system. The present study examined the effects of bright light (>5,000 lux) on exercise-induced acceleration of reentrainment because timed bright lights are known to reset the circadian pacemaker. Fifteen male subjects spent 12 days in temporal isolation. The sleep schedule was advanced from habitual sleep times by 8 h for 4 days, which was followed by a free-run session. In the shift session, bright lights were given during the waking time. Subjects in the exercise group performed 2-h bicycle running twice a day. Subjects in the control kept quiet. As a result, the sleep-wake cycle was fully entrained by the shift schedule in both groups. Bright light may strengthen the resetting potency of the shift schedule. By contrast, the circadian melatonin rhythm was phase-advanced by 6.9 h on average in the exercise group but only by 2.0 h in the control. Thus physical exercise prevented otherwise unavoidable internal desynchronization. Polysomnographical analyses revealed that deterioration of sleep quality by shift schedule was protected by physical exercise under bright lights. These findings indicate differential regulation of sleep-wake cycle and circadian melatonin rhythm by physical exercise in humans. The melatonin rhythm is regulated primarily by bright lights, whereas the sleep-wake cycle is by nonphotic time cues, such as physical exercise and shift schedule.

Daily exposure to a running wheel entrains circadian rhythms in mice in parallel with development of an increase in spontaneous movement prior to running-wheel access
Yujiro Yamanaka, Sato Honma, Ken-ichi Honma
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 305, 11, R1367, R1375, AMER PHYSIOLOGICAL SOC, Dec. 2013, [Peer-reviewed]
English, Scientific journal, Entrainment of circadian behavior rhythms by daily exposure to a running wheel was examined in mice under constant darkness. Spontaneous movement was individually monitored for more than 6 mo by a thermal sensor. After establishment of steady-state free running, mice were placed in a different cage equipped with a running-wheel for 3 h once per day at 6 AM. The daily exchange was continued for 80 days. The number of wheel revolutions during exposure to the running wheel was also measured simultaneously with spontaneous movement. In 13 out of 17 mice, circadian behavior rhythm was entrained by daily wheel exposure, showing a period indistinguishable from 24 h. The entrainment occurred in parallel with an increase in spontaneous movement immediately prior to the daily wheel exposure. A similar preexposure increase was observed in only one of four nonentrained mice. The preexposure increase appeared in 19.5 days on average after the start of daily wheel exposure and persisted for 36 days on average after the termination of the exposure schedule. The preexposure increase was detected only when daily wheel exposure came into the activity phase of the circadian behavior rhythm, which was accompanied by an increase in the number of wheel revolutions. These findings indicate that a novel oscillation with a circadian period is induced in mice by daily exposure to a running wheel at a fixed time of day and suggest that the oscillation is involved in the nonphotic entrainment of circadian rhythms in spontaneous movement.

低温暴露による新生ラットの概日時計の位相シフト.
吉川朋子, 松野亜美, 山仲勇二郎, 西出真也, 本間さと, 本間研一
北海道医誌, 88, 2, 89, 89, Apr. 2013
Japanese, Research institution

Daily exposure to cold phase-shifts the circadian clock of neonatal rats in vivo
Tomoko Yoshikawa, Ami Matsuno, Yujiro Yamanaka, Shin-ya Nishide, Sato Honma, Ken-ichi Honma
European Journal of Neuroscience, 37, 3, 491, 497, 3, Feb. 2013, [Peer-reviewed]
English, Scientific journal, Maternal rhythms entrain the prenatal and neonatal circadian clock in the suprachiasmatic nucleus (SCN) before light entrainment is established. However, the responsible time cues for maternal entrainment are not identified. To examine the role of cyclic changes of ambient temperature in maternal entrainment, blind neonatal rats carrying a clock gene (Per2) bioluminescence reporter were exposed to either of three ambient temperatures (10, 20 or 30°C) during 6-h maternal separation in the early light phase. Cold exposure was performed from postnatal day 1 (P1) to P5. On P6, the SCN was harvested and cultured for photometric monitoring of the circadian rhythm in Per2 expression. Here we demonstrate that the daily cold exposure phase-delayed the circadian Per2 expression rhythms at P6 in a temperature-dependent manner. Exposure to 10°C produced the largest phase-shift of 12.7h, and exposure to 20 and 30°C yielded moderate shifts of 4.1 and 4.5h, respectively. There was no significant difference in the phase-shifts between the latter two temperatures, indicating that ambient temperature is not the sole factor for the phase-shift. Behavioral rhythms that developed after weaning reflected the phase-shift of clock gene expression rhythm in the SCN. These findings indicate that a daily exposure to an ambient temperature of 10°C during the neonatal period is capable of resetting the circadian clock in the SCN, but other factors yet unidentified are also involved in maternal entrainment. Maternal rhythms entrain the prenatal and neonatal circadian clock in the suprachiasmatic nucleus (SCN) before light entrainment is established. However, the responsible time cues for maternal entrainment are not identified. © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.

Loss of circadian rhythm and light-induced suppression of pineal melatonin levels in Cry1 and Cry2 double-deficient mice
Yujiro Yamanaka, Yohko Suzuki, Takeshi Todo, Ken-ichi Honma, Sato Honma
GENES TO CELLS, 15, 10, 1063, 1071, WILEY-BLACKWELL, Oct. 2010, [Peer-reviewed], [Lead author]
English, Scientific journal, Cryptochrome 1 and 2 (Cry1 and Cry2) are considered essential for generating circadian rhythms in mammals. The role of Cry1 and Cry2 in circadian rhythm expression and acute light-induced suppression of pineal melatonin was assessed using Cry1 and Cry2 double-deficient mice (Cry1-/-/Cry2-/-) developed from the C3H strain that synthesizes melatonin. We examined the circadian variation of pineal melatonin under a 12:12-h light-dark (LD) cycle and constant darkness (DD). Light suppression of pineal melatonin concentration was analyzed by subjecting a 30-min light pulse at the peak phase of melatonin concentration. Wild-type mice showed significant rhythmicity in pineal melatonin concentration with the highest level at Zeitgeber time 22 (ZT22, where time of light on was defined as ZT0) under LD or ZT18 on the first day of DD. In contrast, Cry1-/-/Cry2-/- mice did not show significant circadian rhythmicity, with only a small peak observed at ZT22 in LD. Nevertheless, a significant daily variation could be observed under DD, with a small increase at ZT6 and ZT18 h. Melatonin concentration was significantly suppressed by acute light pulse at ZT22 in wild-type mice but not in Cry1-/-/Cry2-/- mice. The present results suggest that Cry genes are required for regulating pineal melatonin synthesis via circadian and photic signals from the suprachiasmatic nucleus of the hypothalamus (SCN).

Physical exercise accelerates reentrainment of human sleep-wake cycle but not of plasma melatonin rhythm to 8-h phase-advanced sleep schedule
Yujiro Yamanaka, Satoko Hashimoto, Yusuke Tanahashi, Shin-ya Nishide, Sato Honma, Ken-ichi Honma
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 298, 3, R681, R691, AMER PHYSIOLOGICAL SOC, Mar. 2010, [Peer-reviewed]
English, Scientific journal, Yamanaka Y, Hashimoto S, Tanahashi Y, Nishide S, Honma S, Honma K. Physical exercise accelerates reentrainment of human sleep-wake cycle but not of plasma melatonin rhythm to 8-h phase-advanced sleep schedule. Am J Physiol Regul Integr Comp Physiol 298: R681-R691, 2010. First published December 30, 2009; doi:10.1152/ajpregu.00345.2009.-Effects of timed physical exercise were examined on the reentrainment of sleep-wake cycle and circadian rhythms to an 8-h phase-advanced sleep schedule. Seventeen male adults spent 12 days in a temporal isolation facility with dim light conditions (<10 lux). The sleep schedule was phase-advanced by 8 h from their habitual sleep times for 4 days, which was followed by a free-run session for 6 days, during which the subjects were deprived of time cues. During the shift schedule, the exercise group (n = 9) performed physical exercise with a bicycle ergometer in the early and middle waking period for 2 h each. The control group (n = 8) sat on a chair at those times. Their sleep-wake cycles were monitored every day by polysomnography and/or weight sensor equipped with a bed. The circadian rhythm in plasma melatonin was measured on the baseline day before phase shift: on the 4th day of shift schedule and the 5th day of free-run. As a result, the sleep-onset on the first day of free-run in the exercise group was significantly phase-advanced from that in the control and from the baseline. On the other hand, the circadian melatonin rhythm was significantly phase-delayed in the both groups, showing internal desynchronization of the circadian rhythms. The sleep-wake cycle resynchronized to the melatonin rhythm by either phase-advance or phase-delay shifts in the free-run session. These findings indicate that the reentrainment of the sleep-wake cycle to a phase-advanced schedule occurs independent of the circadian pacemaker and is accelerated by timed physical exercise.

[Daily phase adjustment of human sleep-wake cycle]
Yamanaka Y, Honma S, Honma K
Nippon rinsho. Japanese journal of clinical medicine, 67, 8, 1475, 1482, 8, Aug. 2009, [Peer-reviewed]

Scheduled exposures to a novel environment with a running-wheel differentially accelerate re-entrainment of mice peripheral clocks to new light-dark cycles
Yujiro Yamanaka, Sato Honma, Ken-Ichi Honma
Genes to Cells, 13, 5, 497, 507, 5, May 2008, [Peer-reviewed]
English, Scientific journal, Effects of scheduled exposures to novel environment with a running-wheel were examined on re-entrainment to 8 h shifted light-dark (LD) cycles of mouse circadian rhythms in locomotor activity and clock gene, Per1, expression in the suprachiasmatic nucleus (SCN) and peripheral tissues. Per1 expression was monitored by a bioluminescence reporter introduced into mice. The animals were exposed to the novel environment for 3 h from the shifted dark onset for four cycles and released into constant darkness. In the phase-advance shift, the circadian rhythm in locomotor activity fully re-entrained in the exposed group, whereas it was in transients in the control. On the other hand, the circadian rhythm of Per1 expression in the SCN almost completely re-entrained in both the control and exposed groups. In the skeletal muscle and lung, the circadian rhythm fully re-entrained in the exposed group, whereas the rhythms in the control did not. In the phase-delay shift, the circadian rhythms in locomotor activity and Per1 expression almost completely re-entrained in both groups. These findings indicate that the scheduled exposures to novel environment with a running-wheel differentially accelerate the re-entrainment of the mouse peripheral clocks to 8 h phase-advanced LD cycles. © 2008 The Authors Journal compilation © 2008 Blackwell Publishing Inc.

Scheduled exposures to a novel environment with a running-wheel differentially accelerate re-entrainment of mice peripheral clocks to new light-dark cycles
Yujiro Yamanaka, Sato Honma, Ken-ichi Honma
GENES TO CELLS, 13, 5, 497, 507, BLACKWELL PUBLISHING, May 2008, [Peer-reviewed]
English, Scientific journal, Effects of scheduled exposures to novel environment with a running-wheel were examined on re-entrainment to 8 h shifted light-dark (LD) cycles of mouse circadian rhythms in locomotor activity and clock gene, Per1, expression in the suprachiasmatic nucleus (SCN) and peripheral tissues. Per1 expression was monitored by a bioluminescence reporter introduced into mice. The animals were exposed to the novel environment for 3 h from the shifted dark onset for four cycles and released into constant darkness. In the phase-advance shift, the circadian rhythm in locomotor activity fully re-entrained in the exposed group, whereas it was in transients in the control. On the other hand, the circadian rhythm of Per1 expression in the SCN almost completely re-entrained in both the control and exposed groups. In the skeletal muscle and lung, the circadian rhythm fully re-entrained in the exposed group, whereas the rhythms in the control did not. In the phase-delay shift, the circadian rhythms in locomotor activity and Per1 expression almost completely re-entrained in both groups. These findings indicate that the scheduled exposures to novel environment with a running-wheel differentially accelerate the re-entrainment of the mouse peripheral clocks to 8 h phase-advanced LD cycles.

Repeated exposures to daytime bright light increase nocturnal melatonin rise and maintain circadian phase in young subjects under fixed sleep schedule
Nana N. Takasu, Satoko Hashimoto, Yujiro Yamanaka, Yusuke Tanahashi, Ayano Yamazaki, Sato Honma, Ken-ichi Honma
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 291, 6, R1799, R1807, AMER PHYSIOLOGICAL SOC, Dec. 2006, [Peer-reviewed]
English, Scientific journal, Repeated exposures to daytime bright light increase nocturnal melatonin rise and maintain circadian phase in young subjects under fixed sleep schedule. Am J Physiol Regul Integr Comp Physiol 291: R1799-R1807, 2006. First published July 13, 2006; doi:10.1152/ajpregu.00211.2006.- Effects of two different light intensities during daytime were examined on human circadian rhythms in plasma melatonin, core body temperature, and wrist activity under a fixed sleep schedule. Sleep qualities as indicated by polysomnography and subjective sleepiness were also measured. In the first week, under dim light conditions (similar to 10 1x), the onset and peak of nocturnal melatonin rise were significantly delayed, whereas the end of melatonin rise was not changed. The peak level of melatonin rise was not affected. As a result, the width of nocturnal melatonin rise was significantly shortened. In the second week, under bright light conditions (similar to 5,000 1x), the phases of nocturnal melatonin rise were not changed further, but the peak level was significantly increased. Core body temperature at the initial sleep phase was progressively elevated during the course of dim light exposure and reached the maximum level at the first night of bright light conditions. Subjective sleepiness gradually declined in the course of dim light exposure and reached the minimum level at the first day of bright light. These findings indicate that repeated exposures to daytime bright light are effective in controlling the circadian phase and increasing the peak level of nocturnal melatonin rise in plasma and suggest a close correlation between phase-delay shifts of the onset of nocturnal melatonin rise or body temperature rhythm and daytime sleepiness.

Effects of physical exercise on human circadian rhythms
Yamanaka Yujiro, Honma Ken-ichi, Hashimoto Satoko, Takasu Nana, Miyazaki Toshihiko, Honma Sato
Sleep and Biological Rhythms, 4, 3, 199, 206, Jul. 2006, [Peer-reviewed]
English, Scientific journal

Cardiovascular autonomic nervous response to postural change in 610 healthy Japanese subjects in relation to age
Y Yamanaka, K Honma
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 124, 1-2, 125, 131, ELSEVIER SCIENCE BV, Jan. 2006, [Peer-reviewed]
English, Scientific journal, To determine the effect of aging on the cardiovascular response to postural change, we examined the cardiovascular sympathetic and parasympathetic response to active standing in 6 10 healthy Japanese subject (6-83 years) measuring the initial heart rate (HR) response for 3 min in the supine and standing position, we also measured the coefficient of variation of R-R interval (CVR-R). As a result, the cardiovascular response to active standing demonstrated a different change with aging between sympathetic rand parasympathetic. Sympathetic function was in a sthenia state in young subjects, and that this function declined with age increasing. Whereas, parasympathetic function was immature enough to inhibit the sympathetic tone in Young subjects and matured at 20 years of age, and had an ability to inhibit sympathetic tone. CVR-R show a linear change that decline with age increasing. These results indicated that the cardiovascular parasympathetic response to active standing shows a characteristic change with aging that differs from cardiovascular parasympathetic at rest represented by CVR-R. The present study is the first report to demonstrate the cardiovascular response to standing in relation to aging in large population. These results suggested that the cardiovascular response to postural change is dependent on subject's age. (c) 2006 Elsevier B.V. All rights reserved.

ヒトサーカディアンリズム振幅に与える光の影響について
高須 奈々, 橋本 聡子, 山仲 勇二郎, 本間 さと, 本間 研一
日本生理学雑誌, 67, 12, 403, 403, (一社)日本生理学会, Dec. 2005
Japanese

睡眠覚醒リズム障害の診断・治療につなげる概日リズムの基礎研究 日常生活下におけるヒト概日リズム測定法の検討　　　　　　　　　　　　　　　
山仲 勇二郎, 日本睡眠学会定期学術集会・日本時間生物学会学術大会合同大会プログラム・抄録集, 45回・30回, 131, 131, Sep. 2023
日本睡眠学会・日本時間生物学会, Japanese

試合開始時刻がプロ野球選手の夜間睡眠に及ぼす影響 ウェアラブルセンサーを用いた評価　　　　　　　　　　　　　　　
宮城 和, 松浦 倫子, 水島 仁, 横田 卓, 山仲 勇二郎, 日本睡眠学会定期学術集会・日本時間生物学会学術大会合同大会プログラム・抄録集, 45回・30回, 325, 325, Sep. 2023
日本睡眠学会・日本時間生物学会, Japanese

「研究成果を栄養教育に生かす」 食事時刻がヒトの概日リズム・糖代謝機能に与える影響　　　　　　　　　　　　　　　
山仲 勇二郎, 日本栄養・食糧学会大会講演要旨集, 77回, 167, 167, Mar. 2023
(公社)日本栄養・食糧学会, Japanese

【インスリン・糖尿病研究の新展開:基礎から臨床まで】糖代謝能にみられる概日リズムに対する咀嚼の効果
山仲 勇二郎, 日本薬理学雑誌, 158, 2, 165, 168, Mar. 2023
生物時計は,バクテリアからヒトに至るまで地球上に生存するすべての生物が獲得した生存戦略である.哺乳類の生物時計機構は,脳内視床下部視交叉上核に存在する中枢時計と視交叉上核外の脳部位および全身の末梢組織に存在する末梢時計からなる階層性多振動体構造から構成される.生物時計の自律振動する分子メカニズムは,時計遺伝子とよばれる一群の遺伝子の転写と翻訳を介する自己制御型のネガティブフィードバックループである.時計遺伝子は,中枢時計である視交叉上核だけでなく末梢組織においても自律振動する概日リズムが確認されており,末梢組織の正常な生理機能との関連が明らかにされている.食後の血糖値上昇に対するインスリン分泌量にも概日リズムが観察される.経口糖負荷試験に対する耐糖能は,朝方に高く夜間に低くなる.耐糖能にみられる概日リズムは,睡眠および概日リズムの同調状態の影響を受けており,臨床においても血糖コントロールにおいても睡眠と概日リズムの調節が重要となる.国内では食事の際によく噛むことが健康にとって重要であることが指摘されている.著者らは,よく噛む=咀嚼の強化が食後の糖代謝能に与える影響が1日のなかで変化するかを健康な成人男子を対象に検討し,朝方の咀嚼の強化が食後のインスリン初期分泌を改善させる効果を持つことを報告した.本総説では,生物時計と糖代謝能,咀嚼の強化が糖代謝能の概日リズムに与える影響について解説する.(著者抄録), (公社)日本薬理学会, Japanese

「研究成果を栄養教育に生かす」 食事時刻がヒトの概日リズム・糖代謝機能に与える影響　　　　　　　　　　　　　　　
山仲 勇二郎, 日本栄養・食糧学会大会講演要旨集, 77回, 167, 167, Mar. 2023
(公社)日本栄養・食糧学会, Japanese

そもそも睡眠とは何か?～睡眠の基礎研究の未来を多様な視点から論じる～ 睡眠覚醒リズム制御機構の解明にむけて 2プロセスモデルの限界と修正　　　　　　　　　　　　　　　
山仲 勇二郎, 日本睡眠学会定期学術集会プログラム・抄録集, 47回, 152, 152, Jun. 2022
(一社)日本睡眠学会, Japanese

概日リズムのHuman Physiologyから迫る睡眠障害 時間隔離実験室を用いたヒト生物時計の構造と機能解析　　　　　　　　　　　　　　　
山仲 勇二郎, 本間 さと, 本間 研一, 日本睡眠学会定期学術集会プログラム・抄録集, 47回, 156, 156, Jun. 2022
(一社)日本睡眠学会, Japanese

LEDを用いた睡眠・概日リズムに優しい照明 ウェアラブル型光照射装置の開発と研究動向　　　　　　　　　　　　　　　
山仲 勇二郎, 久保田 直子, 馬場 謙吉, 田森 雄介, 日本睡眠学会定期学術集会プログラム・抄録集, 47回, 162, 162, Jun. 2022
(一社)日本睡眠学会, Japanese

大学生における自己評価による健康状態に対するCOVID-19による学校の閉鎖の影響とその運動と睡眠との関係性(Impact of school closure due to COVID-19 on self-rated health status and its relationship between exercise and sleep in college students)　　　　　　　　　　　　　　　
久保田 直子, 松浦 倫子, 山仲 勇二郎, 日本睡眠学会定期学術集会プログラム・抄録集, 47回, 202, 202, Jun. 2022
(一社)日本睡眠学会, English

生物時計の基本性質と心身の健康との関わり
山仲勇二郎, 繊維製品消費科学, 62, 8, 2021

Two-oscillator Model for Generating a Diurnal Change of Sleepiness: Ultradian Oscillator and the Circadian Oscillator
田村聖, 松浦倫子, 北村航輝, 山仲勇二郎, 山仲勇二郎, 生理心理学と精神生理学, 39, 1, 2021

Association analysis of Variation in QOL and sleep/biological rhythms in the female student’s menstrual cycle
元池育子, 元池育子, 山仲勇二郎, 松浦倫子, 辛島彰洋, 二口裕太, CHOILEK Siwalee, 中尾光之, 時間生物学, 26, 2, 2020

時間栄養学を実践するために知っておきたいヒト生物時計の構造と機能
山仲勇二郎, 山仲勇二郎, 日本栄養・食糧学会大会講演要旨集, 74th, 2020

EFFECT OF SHORT DURATION-LOW INTENSITY EXERCISE BEFORE BEDTIME ON SLEEP AND MENTAL HEALTH
山仲勇二郎, 若手研究者のための健康科学研究助成成果報告書, 35, 2020

Chronobiology: Human circadian pacemaker and circadian rhythms
山仲勇二郎, 体力科学, 69, 4, 2020

Menstrual Phase-Dependency of Physiological Indices and Qualities of Life
二口裕太, 元池育子, 元池育子, 山仲勇二郎, 辛島彰洋, 片山統裕, 中尾光之, 電子情報通信学会技術研究報告(Web), 120, 215(MBE2020 12-18), 2020

Symposium14-4
山仲勇二郎, Waterhouse Jim, 体力科学, 69, 1, 63, 63, 2020
(一社)日本体力医学会, Japanese

「生物時計」を一つのキーワードに働き方や暮らし方を考え、より健康的な生活を　　　　　　　　　　　　　　　
山仲勇二郎, 看護職向け月刊誌『ベストナース』, Nov. 2019, [Lead author]
Book review

【健康づくりのための時間栄養学】ヒト生物時計と生体リズムの調節機序
山仲 勇二郎, 体育の科学, 69, 11, 780, 787, Nov. 2019
(株)杏林書院, Japanese

プレシジョンニュートリションで拓く健康の未来 時間生物学 生物時計と生体リズム(Future of Healthcare by Precision Nutrition Chronobiology: Biological Clock and Circadian Rhythms in Humans)　　　　　　　　　　　　　　　
山仲 勇二郎, イルシー, 140, 126, 129, Sep. 2019
(NPO)国際生命科学研究機構, English

【子どもの生活環境の変遷と生活習慣の実態】子どもにおける生物時計と生活リズム
山仲 勇二郎, 子どもと発育発達, 17, 1, 36, 41, Apr. 2019
日本発育発達学会, Japanese

【睡眠と医療】睡眠障害が身体に影響を及ぼすメカニズム
山仲 勇二郎, 月刊保団連, 12, 1283, 11, 17, Dec. 2018, [Lead author]
全国保険医団体連合会, Japanese, Introduction commerce magazine

【光環境と睡眠・概日リズム】 光環境と睡眠・概日リズムの基礎
山仲 勇二郎, 睡眠医療, 11, 4, 461, 471, Dec. 2017
ヒトの行動(睡眠覚醒)、体温やホルモン分泌などの生理機能には24時間を1周期とするリズム(概日リズム)があり、脳内の生物時計により発振される。生物時計は、地球の自転により生じる24時間周期の環境周期に同調(外的同調)し、昼行性動物であるヒトが昼間に十分活動し、夜間に質のよい睡眠をとれるように行動および生理機能を時間的に統合している(内的同調)。ヒトの生物時計は、明暗サイクル(高照度光)を同調因子として、深部体温やメラトニンリズムを制御する振動体(視交叉上核に局在)と生活スケジュールや運動といった社会的因子を同調因子として睡眠覚醒リズムを制御する振動体(視交叉上核外脳部位に局在)からなる2振動体モデルが想定されている。良質な睡眠を確保するには、生物時計の外的・内的同調を維持するとともに、生物時計および睡眠にかかわる生理機能(メラトニン、深部体温)に影響する光環境を調整することが必要となる。(著者抄録), (株)ライフ・サイエンス, Japanese

アクチグラフィを用いた双極性障害患者における概日リズム障害の検討
北川 寛, 北市 雄士, 中川 伸, 宇土 仁木, 若槻 百美, 亀山 梨絵, 仲唐 安哉, 山仲 勇二郎, 本間 さと, 本間 研一, 井上 猛, 久住 一郎, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 47th, 188, 188, 2017
日本生物学的精神医学会・日本神経精神薬理学会, Japanese

光環境と睡眠・概日リズムの基礎　　　　　　　　　　　　　　　
山仲勇二郎, 睡眠医療, 11, 4, 401, 411, 2017
Japanese

時間生物学の基礎と体力医学へのメッセージ　　　　　　　　　　　　　　　
山仲 勇二郎, 体力科学, 65, 6, 541, 541, Dec. 2016
(一社)日本体力医学会, Japanese

【糖尿病・うつ・睡眠障害による負のトライアングル】 睡眠障害・うつの糖尿病・身体疾患に及ぼす影響 睡眠障害が糖代謝に与える影響とそのメカニズム
山仲 勇二郎, 本間 研一, 月刊糖尿病, 8, 11, 74, 81, Nov. 2016
(株)医学出版, Japanese

睡眠障害が糖代謝に与える影響とそのメカニズム　　　　　　　　　　　　　　　
山仲勇二郎, 本間研一, 月刊糖尿病, 8, 11, 74, 81, 20 Oct. 2016, [Invited]

ヒト生物時計の構造と概日リズム制御機構　　　　　　　　　　　　　　　
山仲 勇二郎, 日本生気象学会雑誌, 53, 3, S15, S15, Oct. 2016
日本生気象学会, Japanese

生活環境と生物時計
山仲勇二郎, 日本生気象学会雑誌, 53, 2, 69, 81, 08 Aug. 2016, [Invited]

双極性障害における概日リズム異常の経時的評価
山仲 勇二郎, 北市 雄士, 北川 寛, 井上 猛, 本間 さと, 本間 研一, 日本生理学雑誌, 78, 4, 67, 67, Jul. 2016
(一社)日本生理学会, Japanese

生活環境と生物時計
山仲 勇二郎, 日本生気象学会雑誌, 53, 2, 69, 81, Jul. 2016
私たちの行動(睡眠覚醒)、血圧、ホルモン分泌などの生理機能を長時間にわたり観察すると明瞭な24時間リズム(概日リズム)がみられる。概日リズムの発振源は、内因性の自律振動機構である生物時計である。ヒトを含め哺乳類の生物時計は、視床下部の視交叉上核に存在する中枢時計と肝臓、肺、心臓など全身の末梢組織に存在する末梢時計からなる階層構造をもつ。生物時計の役割は、外部環境への同調と生理機能を時間的に統合することであり、ヒトが昼間に活動し夜間に睡眠をとるのに最適な体内環境を整えている。しかし、生活環境および生活リズムが多様化した現代においては、生物時計の支配に逆らった生活を余儀なくされるものも少なくない。睡眠や生体リズムの不安定化は、エネルギー代謝障害や気分障害等と関連することが報告されている。本論では、ヒトの生物時計の基本性質について解説すると共に、光環境、食習慣、運動習慣といった生活環境が生物時計に与える影響について紹介する。(著者抄録), 日本生気象学会, Japanese

若年の心自律神経機能の推移と機能性脳循環疾患 起立時超早期脈拍変動による検討　　　　　　　　　　　　　　　
本間 甲一, 赤荻 悠一, 島田 潤一郎, 仲野 義和, 橋本 憲一郎, 松田 信二, 山仲 勇二郎, 臨床神経学, 55, Suppl., S227, S227, Dec. 2015
(一社)日本神経学会, Japanese

気分障害と概日リズム 位相前進仮説から時計遺伝子変異へ 双極性障害における概日リズム障害 時計遺伝子レポーターによる解析　　　　　　　　　　　　　　　
本間 さと, 山仲 勇二郎, 夏堀 晃世, 吉川 朋子, 井上 猛, 本間 研一, 日本うつ病学会総会・日本認知療法学会プログラム・抄録集, 12回・15回, 129, 129, Jul. 2015
日本うつ病学会・日本認知療法・認知行動療法学会, Japanese

運動と睡眠 再検討 光と運動によるヒト生物時計の調節メカニズム　　　　　　　　　　　　　　　
山仲 勇二郎, 橋本 聡子, 高須 奈々, 増渕 悟, 夏堀 晃世, 棚橋 祐典, 西出 真也, 本間 さと, 本間 研一, 日本睡眠学会定期学術集会プログラム・抄録集, 40回, 136, 136, Jul. 2015
(一社)日本睡眠学会, Japanese

ヒトを対象とした時間生物学研究に魅せられて　　　　　　　　　　　　　　　
山仲勇二郎, 時間生物学, 21, 1, 2, 9, 30 Jun. 2015, [Invited]

高照度光下での運動が生体リズムおよび睡眠に与える影響　　　　　　　　　　　　　　　
山仲 勇二郎, 橋本 聡子, 増渕 悟, 夏堀 晃世, 西出 真也, 本間 さと, 本間 研一, 体力科学, 64, 3, 385, 385, Jun. 2015
(一社)日本体力医学会, Japanese

高照度光下での身体運動は8時間位相前進シフトした生活スケジュールへの血中メラトニンリズムの再同調を促進する　　　　　　　　　　　　　　　
山仲 勇二郎, 橋本 聡子, 増渕 悟, 夏堀 晃世, 西出 真也, 本間 さと, 本間 研一, 日本睡眠学会定期学術集会プログラム・抄録集, 38回, 179, 179, Jun. 2013
(一社)日本睡眠学会, Japanese

Effects of timed physical exercise on phase shifts of human circadian rhythms induced by 8-h advance shift of sleep schedule under bright light conditions
Yujiro Yamanaka, Satoko Hashimoto, Satoru Masubuchi, Akiyo Natsubori, Shin-ya Nishide, Sato Honma, Ken-ichi Honma, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S259, S259, 2013
SPRINGER JAPAN KK, English, Summary international conference

次世代の睡眠基礎研究 時間隔離実験室を使用したヒト生物時計の非光同調機構の解析　　　　　　　　　　　　　　　
山仲 勇二郎, 日本睡眠学会定期学術集会プログラム・抄録集, 37回, 114, 114, Jun. 2012
(一社)日本睡眠学会, Japanese

身体運動と睡眠 運動と生体リズム　　　　　　　　　　　　　　　
山仲 勇二郎, 日本睡眠学会定期学術集会プログラム・抄録集, 37回, 120, 120, Jun. 2012
(一社)日本睡眠学会, Japanese

Regional oscillators in the mouse suprachiasmatic nucleus involved in the compression of circadian behavioral rhythms after an 8 h advance shift of light-dark cycles
Yujiro Yamanaka, Sato Honma, Ken-ichi Honma, NEUROSCIENCE RESEARCH, 71, E172, E172, 2011
ELSEVIER IRELAND LTD, English, Summary international conference

睡眠障害が身体に影響を及ぼすメカニズム (特集 睡眠障害治療により期待される身体疾患の改善)
山仲 勇二郎, 本間 さと, 本間 研一, ねむりと医療, 3, 2, 65, 71, Dec. 2010
先端医学社, Japanese

睡眠障害が身体に及ぼすメカニズム　　　　　　　　　　　　　　　
山仲勇二郎, 本間さと, 本間研一, ねむりと医療, 3, 2, 1, 7, Dec. 2010
Japanese

Acceleration of photic entrainment by non-photic time cues in mouse: effects of exercise and/or stress on central and peripheral clocks
Yujiro Yamanaka, Sato Honma, Ken-ichi Honma, JOURNAL OF PHYSIOLOGICAL SCIENCES, 60, S100, S100, 2010
SPRINGER TOKYO, English, Summary international conference

Daily phase adjustment of human sleep-wake cycle
山仲勇二郎, 本間さと, 本間研一, Japanese journal of clinical medicine, 67, 8, 1475, 1482, Aug. 2009
日本臨床社, Japanese

時差症候群・交代勤務睡眠障害のバイオロジー (特集 産業社会と睡眠)
山仲勇二郎, 橋本聡子, 本間さと, 睡眠医療, 3, 3, 379, 382, Aug. 2009
ライフ・サイエンス, Japanese

睡眠障害の時間治療 (特集 時間薬理学--最適な投与方法を求めて)
山仲勇二郎, 本間さと, 本間研一, 医薬ジャ-ナル, 45, 6, 107, 112, Jun. 2009
医薬ジャ-ナル社, Japanese

EFFECTS OF AMBIENT TEMPERATURE DURING MATERNAL DEPRIVATION ON CIRCADIAN RHYTHMS OF NEONATAL RATS
Tomoko Yoshikawa, Ami Matsuno, Yujiro Yamanaka, Sin-ya Nishide, Sato Honma, Ken-ichi Honma, JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 535, 535, 2009
SPRINGER TOKYO, English, Summary international conference

RE-ENTRAINMENT OF CIRCADIAN RHYTHMS AFTER 8 H ADVANCED LIGHT-DARK CYCLES DEPENDS ON THE TIMING OF EXPOSURES TO NOVEL ENVIRONMENT IN MICE
Yujiro Yamanaka, Sato Honma, Ken-ichi Honma, JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 535, 535, 2009
SPRINGER TOKYO, English, Summary international conference

ヒト血中メラトニンリズムに与える光照度の影響について
高須奈々, 橋本聡子, 山仲勇二郎, 本間さと, 棚橋祐典, 山崎綾野, 西出真也, 野田なつみ, 本間研一, 時間生物学, 11, 2, 2005

起立時超早期脈拍変動検査による神経調節性失神と起立性頻拍症候群の心血管系障害の機序と治療
本間 甲一, 山仲 勇二郎, 山本 達也, 小野寺 正和, 松田 信二, 神経治療学, 21, 3, 311, 311, May 2004
日本神経治療学会, Japanese

高齢者における登山時の自律神経機能
山仲勇二郎, 渡辺剛, 永吉英記, 国士館大学体育研究所報, 21, 27, 34, 2002
国士館大学体育学部附属体育研究所, Japanese

報告書(体育研究所プロジェクト研究)環境変化と心臓自律神経活動との関連
永吉英記, 渡辺剛, 山仲勇二郎, 国士館大学体育研究所報, 21, 141, 144, 2002
国士館大学体育学部附属体育研究所, Japanese

092 総合体育館 08 キャンプ生活がサーカディアンリズムに与える影響
永吉 英記, 渡辺 剛, 川村 協平, 山田 亮, 山仲 勇二郎, 日本体育学会大会号, 53, 0, 511, 511, 2002
一般社団法人 日本体育学会, Japanese

子どもの睡眠ガイドブック : 眠りの発達と睡眠障害の理解
駒田, 陽子, 井上, 雄一
朝倉書店, 2019, 9784254301199, viii, 173p, Japanese

睡眠学I : 「眠り」の科学入門　　　　　　　　　　　　　　　
宮崎総一郎, 北浜邦夫, 井上昌次郎, 林光男, 山仲勇二郎, 松浦倫子, 第7章 生体リズムと睡眠
北大路書房, Nov. 2018, [Joint work]

ヒトの生物時計制御と光環境　　　　　　　　　　　　　　　
山仲勇二郎, 第3章 光の情報利用
朝倉書店, 25 Feb. 2016, 9784254171617, 422, 224-225, Japanese, [Contributor]

脳とこころのプライマリケア第5巻 意識と睡眠　　　　　　　　　　　　　　　
山仲勇二郎, 本間さと, 本間研一, 生物時計に関わる神経系
株式会社シナジー, Jun. 2012, 9784916166296, 864, 313-316, Japanese, [Contributor]

体内時計の科学と産業応用　　　　　　　　　　　　　　　
山仲勇二郎, 本間さと, 体内時計の生理機能
シーエムシー出版, May 2011, 9784781303406, 253, 11-19, Japanese, [Contributor]

からだと温度の事典　　　　　　　　　　　　　　　
山仲勇二郎, 本間さと, 本間研一, 体温リズムの異常
朝倉書店, Apr. 2010, 9784254301021, 640, 139-142, Japanese, Dictionary or encycropedia, [Contributor]

睡眠と体内時計　　　　　　　　　　　　　　　
山仲勇二郎
第24回睡眠健康指導士上級講座, 21 Nov. 2020, Public discourse
21 Nov. 2020 - 21 Nov. 2020, [Invited]

知って得する「睡眠」のチカラ！　　　　　　　　　　　　　　　
山仲勇二郎
令和2年度夕張市市民健康講座, 13 Oct. 2020, Public discourse
13 Oct. 2020 - 13 Oct. 2020, [Invited]

質の良い眠りとは～睡眠のウソ・ホント～　　　　　　　　　　　　　　　
山仲勇二郎
令和2年度第2期えるのす連続講座～女性大学～, 30 Sep. 2020, Public discourse
30 Sep. 2020 - 30 Sep. 2020, [Invited]

Effect of non-photic zeitgebers on circadian rhythm and sleep-wake cycle in humans　　　　　　　　　　　　　　　
山仲勇二郎, 橋本聡子, 本間あや, 本間さと, 本間研一
第27回日本時間生物学会学術大会, 26 Sep. 2020
26 Sep. 2020 - 27 Sep. 2020, [Invited]

運動や食事が睡眠・生体リズムに与える影響　　　　　　　　　　　　　　　
山仲勇二郎
第1回札幌睡眠フォーラム, Nominated symposium
09 Nov. 2019, [Invited]

ぐっすり眠って健康に～すぐに実践できる睡眠改善法～　　　　　　　　　　　　　　　
山仲勇二郎
佐呂間町働き盛り世代の健康づくり講演会, Public discourse
08 Nov. 2019, [Invited]

Effect of mastication on glucose metabolism after high carbohydrate food consumption depends on the number of chew and time of day in healthy subjects　　　　　　　　　　　　　　　
Yujiro Yamanaka, Arisa Sato, Yoshinori Ohtsuka
第26回日本時間生物学会学術大会, 12 Oct. 2019, Poster presentation
12 Oct. 2019 - 13 Oct. 2019

Chronobiology: Circadian clock and circadian rhythms in humans
Yujiro Yamanaka
ILSI Japan第8回「栄養とエイジング」国際会議, 02 Oct. 2019, English, Nominated symposium
01 Oct. 2019 - 02 Oct. 2019, 13081245, [Invited]

ヒト生物時計の特性を考慮した生体リズム調整法と実践例
山仲勇二郎, Jim Waterhouse
第74回日本体力医学会大会, 20 Sep. 2019, Nominated symposium
19 Sep. 2019 - 21 Sep. 2019, 25940757, [Invited]

社会的因子が生物時計と睡眠に与える影響～ヒト生物時計の2振動体モデルから睡眠に適した生活リズムを考える～　　　　　　　　　　　　　　　
山仲勇二郎
第28回日本睡眠環境学会学術大会学術大会, 06 Sep. 2019, Nominated symposium
05 Sep. 2019 - 06 Sep. 2019, [Invited]

睡眠環境の重要性とアプリを用いた睡眠マネジメントの試み　　　　　　　　　　　　　　　
松浦倫子, 田中秀樹, 山仲勇二郎.
第28回日本睡眠環境学会学術大会学術大会, 06 Sep. 2019, Nominated symposium
05 Sep. 2019 - 06 Sep. 2019

睡眠のウソ？ホント？ぐっすり眠るために大切なこと　　　　　　　　　　　　　　　
山仲勇二郎
精神神経科学センター平成31年度学校訪問型睡眠講座事業, Public discourse
10 Jun. 2019, [Invited]

健康と深い関わりをもつ生物時計のふしぎ-すぐに実践できる生物時計の調整法を伝授します-　　　　　　　　　　　　　　　
山仲勇二郎
第61回北大祭公開講義, Japanese, Public discourse
08 Jun. 2019, [Invited]

こころの健康に深く関わる睡眠・生体リズムの仕組み　　　　　　　　　　　　　　　
山仲勇二郎
一般財団法人メンタルケア協会メンタルケア・スペシャリスト養成講座, Japanese, Public discourse
02 Jun. 2019, [Invited]

生物時計の構造と機能～生体リズムの乱れが心身の健康に与える影響～　　　　　　　　　　　　　　　
山仲勇二郎
日本東洋医学会北海道支部2019年度第1回教育講演会, Japanese, Nominated symposium
25 May 2019, [Invited]

生体リズムと健康の深い関わり　　　　　　　　　　　　　　　
山仲勇二郎
全国保険協会（協会けんぽ）北海道支部と株式会社フィリップスの健康づくりの推進に向けた包括的相互連携に関する協定締結式, Japanese, Invited oral presentation
26 Feb. 2019, [Invited]

体内時計と健康のメカニズム　　　　　　　　　　　　　　　
山仲勇二郎
北海道庁 平成30年度生活習慣病予防セミナー, 01 Feb. 2019, Japanese, Public discourse
[Invited], [Domestic Conference]

日の当たる朝で素敵な1日を　　　　　　　　　　　　　　　
山仲勇二郎
北海道大学COI『食と健康の達人』拠点シンポジウム２０１８, 11 Jan. 2019, Japanese, Nominated symposium
[Invited], [Domestic Conference]

生物時計を考慮した健康的な生活リズムを デザインするための基盤研究　　　　　　　　　　　　　　　
山仲勇二郎
2018年度日本生理学会北海道地方会総会, 07 Dec. 2018, Japanese, Invited oral presentation
[Invited], [Domestic Conference]

生物時計を考慮した健康的な生活リズムをデザインするための基盤研究 ～From Laboratory to Field～　　　　　　　　　　　　　　　
山仲勇二郎
2018年度第3回CEHS公開セミナー, 26 Nov. 2018, Japanese, Public discourse
[Invited], [Domestic Conference]

時間生物学を応用した効果的な運動・食事療法〜心リハへの適用の可能性を探る〜　　　　　　　　　　　　　　　
山仲勇二郎
第3回日本心臓リハビリテーション学会北海道支部地方会, 24 Nov. 2018, Japanese, Nominated symposium
[Invited], [Domestic Conference]

ヒト生物時計の調節機序と未解決問題　　　　　　　　　　　　　　　
山仲勇二郎
ヒューマンカロリーメーター協議会, 18 Nov. 2018, Japanese, Nominated symposium
[Invited], [Domestic Conference]

光と運動による生体リズムの調節機序　　　　　　　　　　　　　　　
山仲勇二郎
睡眠障害WEB Seminar, 08 Nov. 2018, Japanese, Public discourse
[Invited], [Domestic Conference]

生物時計を考慮した健康的な生活リズムをデザインするための基盤研究　　　　　　　　　　　　　　　
山仲勇二郎
第1回COI学会, 26 Oct. 2018, Japanese, Oral presentation
[Domestic Conference]

Circadian rhythm of salivary cortisol is associated with the HPA axis activity in response to acute psychological stress in healthy subjects　　　　　　　　　　　　　　　
山仲勇二郎, 元島英雅, 内田健冶
第25回日本時間生物学会学術大会, 21 Oct. 2018, Japanese, Poster presentation
[Domestic Conference]

Effect of seasonal changes in circadian rhythm on glucose metabolism under normal living condition in healthy young subjects　　　　　　　　　　　　　　　
Chihiro Okuyama, Yujiro Yamanaka
第25回日本時間生物学会学術大会, 21 Oct. 2018, Japanese, Poster presentation
[Domestic Conference]

健康に深く関わる生物時計の仕組み　　　　　　　　　　　　　　　
山仲勇二郎
北大総合博物館主催土曜市民セミナー北大の研究最前線, 13 Oct. 2018, Japanese, Public discourse
[Invited], [Domestic Conference]

心理的ストレッサーに対するHPA axisストレス反応の概日リズム　　　　　　　　　　　　　　　
山仲勇二郎
第98回北海道医学大会生理系分科会, 06 Oct. 2018, Japanese, Oral presentation
[Domestic Conference]

トップアスリートに知ってほしい睡眠・仮眠の正しい知識　　　　　　　　　　　　　　　
山仲勇二郎
平成30年度ウィンタースポーツコンソシアム, 14 Sep. 2018, Japanese, Public discourse
[Invited], [Domestic Conference]

ヒト生物時計の構造と機能　　　　　　　　　　　　　　　
山仲勇二郎
2018年度日本生理人類学会夏期セミナー教育講演, 03 Sep. 2018, Japanese, Nominated symposium
[Invited], [Domestic Conference]

からだにやさしいライフスタイル選択サポートの創造 －生物時計同調と快適睡眠で高める女子学生のＱＯＬ－　　　　　　　　　　　　　　　
山仲勇二郎, 元池育子
JSTフェア, 31 Aug. 2018, Japanese, Nominated symposium
[Domestic Conference]

健康に深く関わる生物時計のふしぎ　　　　　　　　　　　　　　　
山仲勇二郎
北海道大学教育学部公開講座2018, 06 Aug. 2018, Japanese, Public discourse
[Invited], [Domestic Conference]

からだにやさしい ライフスタイル選択サポートの創造 －生物時計同調と快適睡眠で高める女子学生のＱＯＬ－　　　　　　　　　　　　　　　
山仲勇二郎
2018年度北海道大学COIサイトビジット, 17 Jul. 2018, Japanese, Nominated symposium
[Domestic Conference]

The role of physical exercise in the non-photic entrainment of the circadian system　　　　　　　　　　　　　　　
Yujiro Yamanaka
The 9th Congress of Asian Sleep Research Society（ASRS）, 12 Jul. 2018, English, Invited oral presentation
[International presentation]

睡眠は健康の宝物～質のよい眠りとは～　　　　　　　　　　　　　　　
山仲勇二郎
道新文化センター1Day講座, 14 Apr. 2018, Japanese, Public discourse
[Domestic Conference]

生物時計を基盤にした健康支援システムの開発をめざして　　　　　　　　　　　　　　　
山仲勇二郎
北大COI参画機関会議, 06 Apr. 2018, Japanese, Invited oral presentation
[Invited], [Domestic Conference]

ぐっすり眠って健康に～睡眠に深く関わる生物時計のふしぎ～　　　　　　　　　　　　　　　
山仲勇二郎
ツルハドラッグ健康セミナー, 24 Mar. 2018, Japanese, Public discourse
[Invited], [Domestic Conference]

時間栄養学を活用した個人に適した食生活をデザインする　　　　　　　　　　　　　　　
山仲勇二郎
平成29年度道民研修会 地域の食生活支援を推進するためのスキルアップ研修会, 20 Mar. 2018, Japanese, Public discourse
[Invited], [Domestic Conference]

生物時計を考慮した健康的な生活リズムをデザインするための基盤研究　　　　　　　　　　　　　　　
山仲勇二郎
北大COIセミナー, 19 Jan. 2018, Japanese, Nominated symposium
[Invited], [Domestic Conference]

生物時計を考慮した健康的な生活リズムをデザインするための基盤研究　　　　　　　　　　　　　　　
山仲勇二郎
第3回COI2021ワークショップ, 22 Nov. 2017, Japanese, Others
[Domestic Conference]

お母さんの生物時計と子供の生物時計のふしぎ　　　　　　　　　　　　　　　
山仲勇二郎
北海道大学COI「食と健康の達人」拠点シンポジウム, 21 Nov. 2017, Japanese, Nominated symposium
[Invited], [Domestic Conference]

時間生物学から笑顔あふれす社会をめざして　　　　　　　　　　　　　　　
山仲勇二郎
COI2021参画機関会議, 20 Nov. 2017, Japanese, Nominated symposium
[Invited], [Domestic Conference]

光環境と非光因子が睡眠・生物時計に与える影響～時間生物学からみた宇宙環境下での睡眠・生体リズム調整～　　　　　　　　　　　　　　　
山仲勇二郎
第63回日本宇宙航空環境医学会, 17 Nov. 2017, Japanese, Nominated symposium
[Invited], [Domestic Conference]

時間生物学と生物時計の不思議　　　　　　　　　　　　　　　
山仲勇二郎
平成29年度アクティブラーニング型学問探求セミナー, 15 Nov. 2017, Japanese, Public discourse
[Invited], [Domestic Conference]

睡眠と時間生物学　　　　　　　　　　　　　　　
山仲勇二郎
第15回睡眠健康指導士上級講座, 04 Nov. 2017, Japanese, Public discourse
[Invited], [Domestic Conference]

双極性障害における概日リズムの内的脱同調　　　　　　　　　　　　　　　
山仲勇二郎
第24回日本時間生物学会学術大会, 29 Oct. 2017, Japanese, Nominated symposium
[Invited], [Domestic Conference]

時間生物学入門～健康のために知っておきたい生物時計の仕組み～　　　　　　　　　　　　　　　
山仲勇二郎
北大セミナーinオホーツク2017, 07 Oct. 2017, Japanese, Public discourse
[Invited], [Domestic Conference]

A novel animal model for Jet lag syndrome　　　　　　　　　　　　　　　
Yujiro Yamanaka
ISSR 2017 conference, 22 Sep. 2017, English, Nominated symposium
[International presentation]

1人1人の体内時計をつくる　　　　　　　　　　　　　　　
山仲勇二郎
COI2021 第2回ワークショップ, 15 Sep. 2017, Japanese, Oral presentation
[Domestic Conference]

ねむり上手は健康上手～睡眠・生物時計のふしぎ～　　　　　　　　　　　　　　　
山仲勇二郎
道薬検健康セミナー2017, 09 Sep. 2017, Japanese, Public discourse
[Invited], [Domestic Conference]

運動がヒト生物時計の光反応性に与える影響　　　　　　　　　　　　　　　
山仲勇二郎
平成29年度(第50回)照明学会全国大会, 06 Sep. 2017, Japanese, Invited oral presentation
[Invited], [Domestic Conference]

時間栄養学を実践するために知っておきたい生物時計のしくみ　　　　　　　　　　　　　　　
山仲勇二郎
平成29年度中標津保健所管内栄養士会第1回研修会, 14 Jul. 2017, Public discourse
[Invited], [Domestic Conference]

眠りと健康のふかーい関係～ぐっすり眠るためのコツを伝授します～　　　　　　　　　　　　　　　
Yujiro Yamanaka
平成28年度鷹栖町健康づくり講演会, 22 Mar. 2017, Public discourse
[Invited], [Domestic Conference]

時差対策のアップトゥデイト　　　　　　　　　　　　　　　
Yujiro Yamanaka
第60回サッカードクターセミナー, 11 Mar. 2017, Invited oral presentation
[Invited], [Domestic Conference]

健康な毎日を送るために知っておきたい生物時計の仕組み　　　　　　　　　　　　　　　
Yujiro Yamanaka
天使大学2016年度臨地実習に関わる講演会, 19 Feb. 2017, Japanese, Public discourse
[Invited], [Domestic Conference]

Recent advancing the two oscillator model of circadian system in humans　　　　　　　　　　　　　　　
Yujiro Yamanaka, Satoko Hashimoto, Sato Honma, Ken-ichi Honma
The 31th Sapporo Symposium on Biological Rhythms, 10 Nov. 2016, English, Nominated symposium
[Invited], [International presentation]

ヒト生物時計の構造と概日リズム制御機構　　　　　　　　　　　　　　　
Yujiro Yamanaka
第55回日本生気象学会大会, 05 Nov. 2016, Japanese, Invited oral presentation
[Invited], [Domestic Conference]

Exercise and circadian clock in humans　　　　　　　　　　　　　　　
Yujiro Yamanaka
SICEライフエンジニアリング部門シンポジウム2016, 03 Nov. 2016, Japanese, Nominated symposium
[Invited], [Domestic Conference]

Phase-adjustment of human circadian system by bright light and physical exercise　　　　　　　　　　　　　　　
Yujiro Yamanaka, Satoko Hashimoto, Sato Honma, Ken-ichi Honma
The 29th ISC Conference in Suzhou, China, 27 Oct. 2016, English, Nominated symposium
[Invited], [International presentation]

生物時計の仕組みから子どもの健康を考える　　　　　　　　　　　　　　　
Yujiro Yamanaka
第3回子どものからだと心・北海道研究会議, 09 Oct. 2016, Japanese, Nominated symposium
[Invited], [Domestic Conference]

生物時計と睡眠～生体リズムを調節し質のよい睡眠を～　　　　　　　　　　　　　　　
Yujiro Yamanaka
第8回臨床睡眠医学学会サテライトシンポジウム, 07 Aug. 2016, Japanese, Nominated symposium
[Invited], [Domestic Conference]

時間生物学の基礎と体力医学へのメッセージ　　　　　　　　　　　　　　　
Yujiro Yamanaka
第18回日本体力医学学会北海道地方会学術集会, 23 Apr. 2016, Japanese, Invited oral presentation
[Invited], [Domestic Conference]

異なる照明条件下でのでの身体運動がヒト概日リズムの位相変化に与える影響　　　　　　　　　　　　　　　
山仲勇二郎, 橋本聡子, 増渕悟, 夏堀晃世, 西出真也, 本間さと, 本間研一
第20回日本時間生物学会学術大会, 09 Nov. 2013, Japanese, Poster presentation
[Domestic Conference]

高照度光下での身体運動がヒト概日リズムの位相調節に与える影響　　　　　　　　　　　　　　　
山仲勇二郎, 橋本聡子, 増渕悟, 夏堀晃世, 西出真也, 本間さと, 本間研一
第90回日本生理学会大会, 29 Mar. 2013, Japanese, Poster presentation
[Domestic Conference]

明暗周期位相変位後のマウス行動リズムを制御する視交叉上核領域振動体の探索　　　　　　　　　　　　　　　
山仲勇二郎, 本間さと, 本間研一
第19回日本時間生物学会学術大会, 15 Sep. 2012, Japanese, Oral presentation
[Domestic Conference]

1日1食の制限食事がヒトに給餌性リズムを発現させるか
本間研一, 山仲勇二郎, 橋本聡子, 本間さと
第19回日本時間生物学会学術大会, 15 Sep. 2012, Japanese, Poster presentation
[Domestic Conference]

腕時計型行動計により計測されたヒト行動リズムから内的脱同調の有無を判断する　　　　　　　　　　　　　　　
橋本聡子, 本間研一, 山仲勇二郎, 本間さと
第19回日本時間生物学会学術大会, 15 Sep. 2012, Japanese, Poster presentation
[Domestic Conference]

母子同調因子としての環境温: in vivo における視交叉上核の温度感受性　　　　　　　　　　　　　　　
吉川朋子, 松野亜美, 山仲勇二郎, 西出真也, 本間さと, 本間研一
第19回日本時間生物学会学術大会, 15 Sep. 2012, Japanese, Public symposium
[Domestic Conference]

時間隔離実験室を使用したヒト生物時計の非光同調機構の解析　　　　　　　　　　　　　　　
山仲勇二郎, 橋本聡子, 高須奈々, 棚橋祐典, 西出真也, 本間さと, 本間研一
第37回日本睡眠学会定期学術集会, 28 Jun. 2012, Japanese, Public symposium
[Domestic Conference]

運動と生体リズム　　　　　　　　　　　　　　　
山仲勇二郎, 橋本聡子, 増渕悟, 夏堀晃世, 西出真也, 本間さと, 本間研一
第37回日本睡眠学会定期学術集会, 28 Jun. 2012, Japanese, Public symposium
[Domestic Conference]

How to measure human circadian rhythms　　　　　　　　　　　　　　　
Yujiro Yamanaka, Satoko Hashimoto, Sato Honma, Ken-ichi Honma
International Symposium and Workshop on Frontiers in Sleep and Biological Rhythms Research, 30 Apr. 2012, Japanese, Nominated symposium
[Domestic Conference]

高照度光下での身体運動がヒト概日リズムの位相調節に与える影響　　　　　　　　　　　　　　　
山仲勇二郎, 橋本聡子, 増渕悟, 夏堀晃世, 西出真也, 本間さと, 本間研一
第89回日本生理学会大会, 31 Mar. 2012, Japanese, Poster presentation
[Domestic Conference]

Effect of physical exercise on re-entrainment of human circadian rhythms to an 8 h advanced sleep schedule under bright light coditions　　　　　　　　　　　　　　　
Yujiro Yamanaka, Satoko Hashimoto, Satoru Masubuchi, Akiyo Kameyama, Shin-ya Nishide, Sato Honma, Ken-ichi Honma
International Symposium on Photic Bioimaging Satellite Symposium of Worldsleep 2011 on Human Circadian Clock- the 50th anniversary of temporal isolation study, 21 Oct. 2011, English, Poster presentation
[International presentation]

Effect of scheduled physical exercise on re-entrainment of human circadian rhythms to an 8 h advanced sleep schedule in isolation facility　　　　　　　　　　　　　　　
Yujiro Yamanaka, Satoko Hashimoto, Satoru Masubuchi, Akiyo Kameyama, Shin-ya Nishide, Sato Honma, Ken-ichi Honma
WorldSleep 2011, 15 Oct. 2011, English, Public symposium
[International presentation]

明暗周期位相シフト時のマウス行動リズムを制御する視交叉上核内領域振動体の探索　　　　　　　　　　　　　　　
山仲勇二郎, 本間さと, 本間研一
第34回神経科学学会, 14 Sep. 2011, English, Poster presentation
[Domestic Conference]

明暗周期位相シフト後のマウス行動リズムと 視交叉上核領域内 mPeriod1 発現リズム　　　　　　　　　　　　　　　
山仲勇二郎, 本間さと, 本間研一
第91回北海道医学大会生理系分科会, 27 Aug. 2011, Japanese, Oral presentation
[Domestic Conference]

The master and slave oscillators for behavioral rhythm in mice　　　　　　　　　　　　　　　
Yujiro Yamanaka, Sato Honma, Ken-ichi Honma
The III World Congress of Chronobiology, 09 May 2011, English, Nominated symposium
[Invited], [International presentation]

母子分離中の環境温度が新生ラットの概日リズムにおよぼす影響　　　　　　　　　　　　　　　
吉川朋子, 松野亜美, 山仲勇二郎, 西出真也, 本間さと, 本間研一
第17回日本時間生物学会学術大会, 20 Nov. 2010, Japanese, Poster presentation
[Domestic Conference]

時間隔離実験室を利用したヒト生物時計の構造解析. シンポジウム「体内時計制御工学を目指して」　　　　　　　　　　　　　　　
山仲勇二郎
第17回日本時間生物学会学術大会, 20 Nov. 2010, Japanese, Nominated symposium
[Invited], [Domestic Conference]

マウス末梢時計の8時間位相前進させた明暗周期への再同調は新奇環境暴露により促進される　　　　　　　　　　　　　　　
山仲勇二郎, 本間さと, 本間研一
第90回北海道医学大会生理系分科会・日本生理学会北海道地方会, 25 Sep. 2010, Japanese, Oral presentation
[Domestic Conference]

運動が生体リズムに与える影響. ワークショップ 生体リズムとスポーツパフォーマンス-基礎研究から現場へ　　　　　　　　　　　　　　　
山仲勇二郎
第65回日本体力医学会大会, 16 Sep. 2010, Japanese, Nominated symposium
[Invited], [Domestic Conference]

明暗周期位相シフト後の新奇環境暴露によるマウス末梢時計の再同調促進効果に関する考察　　　　　　　　　　　　　　　
山仲勇二郎, 本間さと, 本間研一
第87回生理学会大会, 21 May 2010, English, Oral presentation
[Domestic Conference]

脱同調パラダイム実験によるヒト生物時計の構造解析　　　　　　　　　　　　　　　
山仲勇二郎, 橋本聡子, 中村宏次, 本間さと, 本間研一
日本睡眠学会第34回定期学術集会, 26 Oct. 2009, Japanese, Oral presentation
[Domestic Conference]

ヒト生体リズムの非光再同調に与える 身体運動の影響　　　　　　　　　　　　　　　
山仲勇二郎, 橋本聡子, 西出真也, 棚橋祐典, 本間さと, 本間研一
第15回日本時間生物学会学術大会, 08 Nov. 2008, Japanese, Oral presentation
[Domestic Conference]

低照度環境下における強制的睡眠覚醒スケジュール時の身体運動が深部体温リズムおよび睡眠脳波に与える影響　　　　　　　　　　　　　　　
山仲勇二郎, 橋本聡子, 本間さと, 本間研一
H20年度体温研究会, 19 Sep. 2008, Japanese, Oral presentation
[Domestic Conference]

Differential effects of scheduled novel environment with a running-wheel on re-entrainment of circadian clocks in the suprachiasmatic nuclei and peripheral tissues in mice subjected to an 8 h shifted light-dark cycles: implications for jet lag　　　　　　　　　　　　　　　
Yujiro Yamanaka, Sato Honma, Ken-ichi Honma
第85回日本生理学会, 25 Mar. 2008, English, Poster presentation
[Domestic Conference]

8時間位相シフトさせた明暗周期に対するマウス行動リズムの再同調は新規環境暴露により促進される　　　　　　　　　　　　　　　
山仲勇二郎, 本間さと, 本間研一
第4回環境生理プレコングレス, 24 Mar. 2008, Japanese, Oral presentation
[Domestic Conference]

Maturity process of cardiovascular autonomic function in resting supine position and response to postural change.　　　　　　　　　　　　　　　
Yujiro Yamanaka, Koichi Honma
5th Congress of the International Society for Autonomic Neuroscience: ISAN 2007, 05 Oct. 2007, English, Poster presentation
[International presentation]

脱同調パラダイムによるヒト生物時計の構造解析　　　　　　　　　　　　　　　
山仲勇二郎
第3回体温調節温度受容研究会, 27 Sep. 2007, Japanese, Oral presentation
[Domestic Conference]

Four day physical exercise accelerates entrainment of human sleep-wake cycle but not of plasma melatonin rhythms to shifted sleep schedule under dim light condition.　　　　　　　　　　　　　　　
Yujiro Yamanaka, Satoko Hashimoto, Yusuke Tanahashi, Shin-ya Nishide, Sato Honma, Ken-ichi Honma
World Federation of Sleep Research and Sleep Medicine Society. 2007, 02 Sep. 2007, English, Poster presentation
[International presentation]

Photic and non-photic entrainment of circadian behavioral rhythms in histamine decarboxylase knock out mice　　　　　　　　　　　　　　　
Yujiro Yamanaka, Hiroshi Abe, Hiroshi Ohtsu, Sato Honma, Ken-ichi Honma
第84回日本生理学会, 20 Mar. 2007, English, Oral presentation
[Domestic Conference]

4日間の身体運動によるヒト生物時計の位相反応曲線の作成　　　　　　　　　　　　　　　
山仲勇二郎, 橋本聡子, 高須奈々, 西出真也, 棚橋祐典, 本間さと, 本間研一
第3回環境生理プレコングレス, 19 Mar. 2007, Japanese, Oral presentation
[Domestic Conference]

体温リズムの生物時計による内因性支配と非光同調因子による外因性修飾作用　　　　　　　　　　　　　　　
山仲勇二郎, 橋本聡子, 高須奈々, 本間さと, 本間研一
第2回体温調節温度受容研究会, 11 Jan. 2007, Japanese, Oral presentation
[Domestic Conference]

低照度環境下での身体運動が睡眠脳波、心臓自律神経活動に及ぼす影響　　　　　　　　　　　　　　　
山仲勇二郎, 橋本聡子, 高須奈々, 本間さと, 本間研一
日本睡眠学会第31回定期学術集会, 29 Jun. 2006, Poster presentation
[Domestic Conference]

Non-photic entrainment to scheduled 3-h wheel running in the mouse circadian rhythm　　　　　　　　　　　　　　　
Yujiro Yamanaka, Hiroshi Abe, Sato Honma, Ken-ichi Honma
第83回日本生理学会, 28 Mar. 2006, Oral presentation
[Domestic Conference]

身体運動に対するヒト生物時計の位相反応性～位相反応曲線におけるCross over pointの同定～　　　　　　　　　　　　　　　
山仲勇二郎, 橋本聡子, 高須奈々, 宮崎俊彦, 本間さと, 本間研一
第2回環境生理学プレコングレス, 27 Mar. 2006, Oral presentation
[Domestic Conference]

Effects of exercise for circadian rhythm　　　　　　　　　　　　　　　
Yujiro Yamanaka, Ken-ichi Honma, Toshihiko Miyazaki, Satoko Hashimoto, Sato Honma
World Federation of Sleep Research and Sleep Medicine Society 2005, 22 Sep. 2005, English, Nominated symposium
[Invited], [International presentation]

生体リズムと体温　　　　　　　　　　　　　　　
山仲勇二郎, 高須奈々, 橋本聡子, 本間研一
体温調節温度受容研究会, Sep. 2005, Oral presentation
[Domestic Conference]

体位変化に対する心血管系自律神経機能の加齢現象～起立時超早期脈拍変動による検討，新たな健常値の提言～　　　　　　　　　　　　　　　
山仲勇二郎, 本間甲一
第57回日本自律神経学会総会, 29 Oct. 2004, Oral presentation
[Domestic Conference]

Health and Society: Advanced lecture for Health and Sports Science　　　　　　　　　　　　　　　
Hokkaido University
Apr. 2017 - Present

健康教育学特論：時間生物学　　　　　　　　　　　　　　　
北海道大学大学院教育学研究院
Apr. 2016 - Present

生活健康学　　　　　　　　　　　　　　　
北海道大学教育学部
Apr. 2016 - Present

教育衛生学　　　　　　　　　　　　　　　
北海道大学教育学部
Apr. 2016 - Present

小児学校保健　　　　　　　　　　　　　　　
北海道大学教育学部
Apr. 2016 - Present

体育学B　　　　　　　　　　　　　　　
北海道大学
Apr. 2016 - Present

体育学A　　　　　　　　　　　　　　　
北海道大学
Apr. 2016 - Present

生理学　　　　　　　　　　　　　　　
北海道大学医学部医学科
Apr. 2009 - Mar. 2017

生理学実習　　　　　　　　　　　　　　　
北海道大学医学部医学科
Apr. 2009 - Mar. 2016

Apr. 2008 - Present
Society for Research on Biological Rhythms　　　　　　　　　　　　　　　

Apr. 2004 - Present
日本生理学会　　　　　　　　　　　　　　　

Apr. 2004 - Present
日本睡眠学会　　　　　　　　　　　　　　　

Apr. 2004 - Present
日本時間生物学会　　　　　　　　　　　　　　　

Basic circadian rhythm research for establishing of the novel exercise program
Grants-in-Aid for Scientific Research
01 Apr. 2024 - 31 Mar. 2029
山仲 勇二郎
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 24K02808

在宅寝たきり療養者と家族介護者の概日リズムの実態解明と支援の構築
科学研究費助成事業
01 Apr. 2023 - 31 Mar. 2027
久保田 直子, 山仲 勇二郎
日本学術振興会, 基盤研究(C), 北海道科学大学, 23K10347

Understanding of sleep-wake regulatory mechanisms in nature
Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
27 Oct. 2020 - 31 Mar. 2024
小野 大輔, 池上 啓介, 山仲 勇二郎
睡眠・覚醒や体温調節など、ほぼすべての生理機能には２４時間を１サイクルとする“概日リズム”が存在し、“概日時計”がその時間的調節を担う。我々の身体を構成する すべての細胞に、概日時計は備わり、時計遺伝子の転写・翻訳を介したフィードバックループがその中心的役割を示す。概日時計の中でも、中枢時計である「視交叉上核」はペースメーカーとして機能し、睡眠・覚醒のリズムを調節する。


近年の光遺伝学の技術開発により、様々な生命現象を調節する神経回路が同定されてきている。哺乳類の睡眠研究においても、実験室の飼育環境下における睡眠・覚醒調節に関わる神経細胞が同定されてきた。一方、自然界における動物の睡眠研究はほとんどなされていない。しかし、最近になって自然界における睡眠・覚醒パターンが、実験室の結果とは大きく異なる事が示唆されてきた。国際生物学賞を受賞したDr. S. Daan（故）は、自然条件下（野外）でマウスを飼育すると、夜行性から昼行性にシフトする事を発見した。本研究では、自然環境下における動物行動の調節を担う神経メカニズムの解明を行う。
Japan Society for the Promotion of Science, Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)), Nagoya University, 20KK0177

Mechanism of exercise effect on the central circadian pacemaker
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
01 Apr. 2019 - 31 Mar. 2024
山仲 勇二郎
本研究では雄性のC57BL/6-Tg(Period1-luc)マウスを用いて、マウスの自発活動リズムが①LD12:12明暗サイクルに同調、②恒常暗下でフリーラン、③恒常暗下で1日3時間の回転輪のついた新しいケージに移す新奇環境暴露スケジュールに同調、の3条件下で視交叉上核、弓状核、肝臓、骨格筋を採取し、生物発光測定装置を用いてPer1-lucリズムを測定した。各組織における培養翌日のPer1-lucリズムのピーク位相をリズム指標として、行動リズムの活動開始・終了位相および中枢・末梢時計間の位相関係を解析した。その結果、明暗サイクル同調時と新奇環境暴露スケジュール同調時におけるSCNのPer1-lucリズムのピーク位相はいずれも主観的明期(マウスの休息期)にみられた。肝臓および骨格筋のピーク位相は、主観的暗期(マウスの活動期)にみられた。行動リズム位相とSCN、肝臓、骨格筋のPer1-lucリズムの位相関係は明暗サイクル下と新規環境暴露スケジュール同調時で有意な差は認められなかった。一方、弓状核のPer1-lucリズム、明暗サイクル下および恒常暗でのフリーラン条件下では主観的暗期にピーク位相がみられたが、新奇環境暴露同調時に明暗サイクルおよび恒常暗条件に比べ、有意に位相前進し主観的明期にピーク位相がみられた。本研究により、恒常暗下での習慣的な運動スケジュールがマウスSCNの同調因子として作用し、明暗サイクル同調時におけるSCNと行動リズム、肝臓、骨格筋の末梢時計間の位相関係を維持した状態で同調することを明らかにした。
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 19H03993

光と運動による生物時計調節メカニズムの解明：運動による効果的な生体リズム調整法の開発を目指して　　　　　　　　　　　　　　　
Apr. 2020 - Mar. 2021
山仲勇二郎
公益財団法人 ヤマハ発動機スポーツ振興財団, 第14期生(2020年度)スポーツチャレンジ研究助成(基本), 北海道大学, Principal investigator

就寝前の低強度短時間運動が睡眠・メンタルヘルスに及ぼす影響　　　　　　　　　　　　　　　
公益財団法人明治安田厚生事業団若手研究者のための健康科学研究助成第35回助成金〈一般〉
Oct. 2018 - Feb. 2020
山仲勇二郎
公益財団法人明治安田厚生事業団, Principal investigator, Competitive research funding

糖代謝能の概日リズムと咀嚼運動に注目した新たな栄養食事指導法の提言
公益財団法人秋山生命科学振興財団－2018年度研究助成〈一般〉－
Jul. 2018 - Mar. 2019
山仲勇二郎
公益財団法人秋山生命科学振興財団, Principal investigator, Competitive research funding

からだにやさしいライフスタイル選択サポートの創造－生物時計同調と快適睡眠で高める女子学生のＱＯＬ－　　　　　　　　　　　　　　　
センター・オブ・イノベーションプログラム COI若手連携研究ファンド 平成30年度連携研究
Apr. 2018 - Mar. 2019
山仲勇二郎
国立研究開発法人科学技術振興機構, Principal investigator, Competitive research funding

光と運動による生体リズムの調節メカニズム
科学研究費補助金(基盤研究Ｃ)
Apr. 2016 - Mar. 2019
山仲勇二郎
文部科学省, Principal investigator, Competitive research funding

高照度光下での運動が生物時計の光反応性に与える影響　　　　　　　　　　　　　　　
平成28年度睡眠健康推進機構学術研究助成
Oct. 2016 - Mar. 2018
山仲勇二郎
睡眠健康推進機構, Principal investigator, Competitive research funding

運動時の照明条件が睡眠・生体リズムに与える影響　　　　　　　　　　　　　　　
第25回一般社団法人照明学会研究・教育助成 (奨励研究)
Jul. 2016 - Mar. 2017
山仲勇二郎
一般社団法人照明学会, Principal investigator, Competitive research funding

脳ペプチドダイアリシス法を応用した生物時計からの液性出力因子による概日リズム調節メカニズムの解明　　　　　　　　　　　　　　　
平成27年度 公益信託 成茂神経科学研究助成基金
Jul. 2015 - Mar. 2016
山仲勇二郎
公益信託 成茂神経科学研究助成基金, Principal investigator, Competitive research funding

Novel peptide-dialysis system to assess the effect of physical exercise on the circadian clock
Grants-in-Aid for Scientific Research
2013 - 2015
Yamanaka Yujiro
Brain microdialysis is a powerful technique for measuring a neurotransmitter in extracellular fluid from free moving animals. By using this technique with some modification for measuring a large molecule (neuropeptide), we examined circadian rhythm of neuropeptide released from a central circadian pacemaker of suprachiasmatic nucleus in free moving mice. The mice were placed under a normal light-dark cycle and constant darkness conditions for 2-4 days. During this period, artificial cerebrospinal fluid was perfused at a flow rate of 1 μl/min and the dialysate were collected every 1 h. As a result, circadian rhythm of AVP in dialysate was detected in some mice that the dialysis probe was inserted close to the SCN. The highest value was observed in early subjective day (ZT4). However, in other mice, circadian rhythms of AVP in dialysate were not detected. Technical improvement would be needed in future studies.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Principal investigator, Competitive research funding, 25350808

食事時刻がヒトの生体リズムおよびエネルギー代謝調節に与える影響　　　　　　　　　　　　　　　
公益財団法人 石本記念デサントスポーツ科学振興財団 第36回研究助成
Jun. 2014 - Nov. 2014
山仲勇二郎
公益財団法人 石本記念デサントスポーツ科学振興財団, Principal investigator, Competitive research funding

Food entrainable circadian rhythm in humans
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
01 Apr. 2011 - 31 Mar. 2014
HONMA Ken-ichi, NISHIDE Shin-ya, YAMANAKA Yujiro, HASHIMOTO Satoko
Appearance of premeal anticipatory hormone peak and entrainability of restricted meal schedule were examined in humans who stayed in a temporal isolation facility without knowing the time of day. Meal was supplied once a day for 10 days. As a result, the premeal peak was not detected in plasma melatonin, cortisol, insulin, ghrelin, and leptin. On the other hand, the sleep-wake cycle was entrained by the meal schedule, whereas the circadian melatonin rhythm was not entrained showing phase-delay shifts. These findings indicated that the so-called food entrainable circadian rhythm failed to appear in humans under the present conditions, and that the meal schedule was the time cue for the sleep-wake cycle but not for the circadian pacemaker.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 23390047

食事制限がヒトの生体リズムおよびエネルギー代謝調節に与える影響　　　　　　　　　　　　　　　
公益財団法人サッポロ生物科学振興財団 第1回研究助成
Jun. 2012 - Apr. 2013
山仲勇二郎
公益財団法人サッポロ生物科学振興財団, Principal investigator, Competitive research funding

身体運動による生体リズム調節法の開発
科学研究費補助金(若手研究(B))
2011 - 2012
山仲 勇二郎
(研究の目的)本研究は、ヒト生物時計に対する高照度光と身体運動の相互作用を時間隔離実験室を使用し、行動（睡眠覚醒）、ホルモン（メラトニン）、深部体温のリズムを測定し検証する。(実施計画)本研究は、健康な20代の成人男性を対象に時間隔離実験室を使用して行う。被験者は、時間隔離実験室内で12泊13日生活する。実験は、通常のリズム位相を測定するベースライン期間(3日)、通常の睡眠時間帯を8時間位相前進する強制スケジュール期間(4日)、そして、睡眠時間や食事のタイミングを制限しないフリーラン期間(6日)、3つのセッションからなる。ベースラインおよび強制スケジュール期間中は8時間睡眠、16時間覚醒とし、覚醒時の実験室内の照度は約3000ルクスの高照度光とし、睡眠中は約0ルクスである。メラトニンリズムを計測するための採血時およびフリーラン期間中は約10ルクスの低照度に設定する。(研究実績)平成23年度の研究計画に従い、3回の隔離実験を行い、対照群4名、運動群4名より以下の結果を得た。[睡眠覚醒リズム]対照群（4名中3名）、運動群（4名）ともにフリーラン第1日目の睡眠開始位相は8時間前進した就寝時刻付近にみられ睡眠覚醒リズムは身体運動を負荷しなくとも高照度光のみで再同調が完了していた。[メラトニリズム]対照群、運動群ともに8時間前進スケジュール最終日ではベースライン期間から5～6時間の位相前進が認められた。メラトニンリズムの位相前進量は、対照群と運動群間では同程度であり、運動によるメラトニンリズムの再同調促進効果は認められなかった。
文部科学省, 若手研究(B), 北海道大学, Principal investigator, Competitive research funding, 23700770

Synchronization effects of physical exercise on human peripheral clocks regulating behavior rhythms
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
2009 - 2011
HASHIMOTO Satoko, TANAHASHI Yuhsuke, YAMANAKA Yujiro
To clarify whether physical exercise is a time cue for the human circadian clock and the mechanism by which physical exercise entrains the clock, we performed a series of experiment under temporal isolation using an 8h phase-advanced desynchrony protocol. Adult female subjects were required to perfome physical exercise of 2 hour duration twice a day using bicycle ergometer. The circadian rhythms in plasma melatonin and deep body temperature, which are believed to be regulated by the central circadian pacemaker, were measured simultaneously with the sleep-wake cycle which is thought to be driven by the peripheral clock. As a result, the re-entrainment of the sleep-wake cycle to a 8 h phase-advanced schedule was accelerated by timed physical exercise under dim light of ca. 10 lx, whereas the plasma melatonin did not phase-advance regardless of timed physical exercise. On the other hand, the re-entrainment of the sleep-wake cycle was accomplished regardless of timed physical exercise under bright light of ca. 5,000 lx, whereas the plasma melatonin rhythm phase-advanced but did not fully entrain but phase-advanced with or without timed physical exercise. The findings indicate that time physical exercise has a potency to entrain the sleep-wake cycle, but the effect is masked under bright light conditions.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 21590249

Acceleration mechanism of re-entrainment of circadian rhythms by physical exercise in mammals
Grants-in-Aid for Scientific Research(若手研究(B))
2009 - 2010
yujiro YAMANAKA
The aim of present study was to clarify acceleration mechanism of re-entrainment of circadian behavioral and clock gene expression rhythm in peripheral tissues (peripheral clocks) to a large shift of light-dark cycle (e.g. jet-lag travel in humans) by physical exercise in mammals. We could demonstrate that the effect of physical exercise, such as exposure to new cage with a running-wheel, on the re-entrainment of peripheral clock was dependent on the timing of exposure. During the transient days in behavior after shift of light cycle, circadian clock gene expression rhythm in the central clock in the suprachiasmatic nucleus (SCN) showed a regional difference in the waveforms and phases. These finding addresses a new hypothesis that the scheduled physical exercise directly affect on the regional oscillator in the SCN. If so, it leads to increase a coupling strength between the SCN and peripheral clock and to accelerate re-entrainment of peripheral clocks by physical exercise.
Ministry of Education, Culture, Sports, Science and Technology, 若手研究(B), 北海道大学, Principal investigator, Competitive research funding, 21700650

Analysis of multi-oscillator structure of biological clock
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
2008 - 2010
HONMA Ken-Ichi, TANAHASHI Yuhsuke, NISHIDE Shinya, NAKAMUEA Tomoko, YAMADA Yoshiko, YASUDA Tsubura, SHUDO Miwako, YAMANAKA Yuhjiro, HASHIMOTO Satoko, TOKUMARU Nobuko
Oscillating neurons in the suprachiasmatic nucleus (SCN), the center of biological clock, constructs more than one regional pacemakers of different characteristics through mutual synchronization. The roles of regional pacemakers depend on the area of SCN, and their interaction determines the length of activity period, showing seasonal changes in behavioral rhythms. The function of biological clock is disrupted by restricted daily feeding or methamphetamine treatment, which is supposed to be due to desynchronization between the central and peripheral clocks. The peripheral clock(s) regulating behavioral rhythms is suggested to reside in the midbrain.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Hokkaido University, 20249010

光照射装置
Patent right, 田森 雄介, 山口 悦範, 山仲 勇二郎, 電制コムテック株式会社, 国立大学法人北海道大学
特願2021-098449, 14 Jun. 2021
特開2023-011076, 24 Jan. 2023
202303020171919238

光照射装置
Patent right, 田森 雄介, 山口 悦範, 山仲 勇二郎, 電制コムテック株式会社, 国立大学法人北海道大学
特願2021-098449, 14 Jun. 2021
特許第7198460号, 21 Dec. 2022
202303003030232482

光照射装置　　　　　　　　　　　　　　　
Patent right
特願2021-098449, 14 Jun. 2021
特許7198460, 21 Dec. 2022

生物時計から見た健康的な食習慣　　　　　　　　　　　　　　　
Jan. 2021
Myself
キューピー株式会社
キューピーニュース
キューピーニュース. 561, 2021.1.28, [Pr]

正しい睡眠で免疫力アップ　　　　　　　　　　　　　　　
Jun. 2020
Myself
北海道文化放送UHB
みんテレ
[Media report]

休校で崩れる生活リズム 心身の健康悪化も 体内時計整える習慣を　　　　　　　　　　　　　　　
May 2020
NHKさっぽろ
北海道のニュース
[Media report]

美と若さの新常識～カラダのヒミツ～　　　　　　　　　　　　　　　
16 Apr. 2020
NHK
NHK BSプレミアム
ダイエットの前に体内時計お直し術, [Media report]

聞きたい新型コロナウイルス 生活リズム整え健康維持　　　　　　　　　　　　　　　
Apr. 2020
北海道新聞
北海道新聞
[Paper]

「よく噛んで食事をする」と食後の血糖上昇を抑えられる 「よく噛む」食事法は朝と夜で効果に差が　　　　　　　　　　　　　　　
11 Dec. 2019
日本医療・健康情報研究所／創新社
保健指導リソースガイド
[Internet]

朝の食事 1口40回かむと「血糖値下げる効果」　　　　　　　　　　　　　　　
06 Dec. 2019
Other than myself
読売新聞
[Paper]

咀嚼が食後血糖値を下げる効果は朝と夜で異なる 朝に咀嚼回数を増やすと最も効果的 インスリン初期分泌を促進　　　　　　　　　　　　　　　
29 Nov. 2019
糖尿病治療研究会 公益財団法人 日本糖尿病財団 日本医療・健康情報研究所
糖尿病リソースガイド
[Internet]

Your body may not cope with evening stress: Study　　　　　　　　　　　　　　　
28 Nov. 2019
Other than myself
Business Standard
[Internet]

Your body may not cope with evening stress: Study　　　　　　　　　　　　　　　
28 Nov. 2019
Other than myself
Can-India News a division of World Media Corp (Canada) Inc
[Internet]

Beware of evening stress　　　　　　　　　　　　　　　
27 Nov. 2019
Science Daily
[Internet]

Beware of evening stress　　　　　　　　　　　　　　　
27 Nov. 2019
Other than myself
Medical Press
[Internet]

Beware of Evening Stress　　　　　　　　　　　　　　　
27 Nov. 2019
Technology Networks Ltd
[Internet]

朝食かむほど血糖値低下 白米１０回→４０回で最大１４％ 北大など研究　　　　　　　　　　　　　　　
27 Nov. 2019
Other than myself
北海道新聞
[Paper]

朝方の咀嚼運動の強化で、食後の血糖値が速やかに低下－北大ほか　　　　　　　　　　　　　　　
26 Nov. 2019
株式会社QLife
医療NEWS QLifePro
[Internet]

【スポーツの力】未来をつくる＜４＞光と運動 快眠の解』
11 Nov. 2019
Other than myself
読売新聞
10724110, [Paper]

あなたの睡眠、間違いかも！眠りの常識ウソ・ホント　　　　　　　　　　　　　　　
02 Sep. 2019
STV
どさんこワイド179
[Media report]

The Health Risks of Evening Stress　　　　　　　　　　　　　　　
26 Jul. 2019
Other than myself
Medium US
[Internet]

Stressresistent am Abend　　　　　　　　　　　　　　　
05 Feb. 2019
Other than myself
Spektrum.de
[Internet]

How to plan your day to get the best out of your brain　　　　　　　　　　　　　　　
01 Feb. 2019
BBC News
[Internet]

Beware of stressful events in the evening　　　　　　　　　　　　　　　
24 Dec. 2018
Other than myself
Health Day
[Internet]

Beware of Stressful Events in the Evening　　　　　　　　　　　　　　　
17 Dec. 2018
Other than myself
MedicineNet
[Internet]

Stress in the evening harder on body than at other times: study　　　　　　　　　　　　　　　
15 Dec. 2018
Other than myself
United Press International, Inc.
[Internet]

Beware of Stressful Events in the Evening　　　　　　　　　　　　　　　
14 Dec. 2018
Other than myself
Doctors Lounge
[Internet]

Beware of Stressful Events in the Evening　　　　　　　　　　　　　　　
14 Dec. 2018
U.S.News
[Internet]

「ストレス反応」は朝と夜で異なる 体内時計をストレスマネジメントに応用　　　　　　　　　　　　　　　
10 Dec. 2018
一般社団法人日本生活習慣病予防協会
[Internet]

夜はリラックスタイムではない！？ストレス防御機能が低下 北大がホルモン変化確認　　　　　　　　　　　　　　　
05 Dec. 2018
日刊工業新聞
[Paper]

Estar stressado à tarde é mais perigoso do que de manhã　　　　　　　　　　　　　　　
03 Dec. 2018
Other than myself
ZAP
[Internet]

Beware getting too stressed in the evening　　　　　　　　　　　　　　　
02 Dec. 2018
Other than myself
DIGITAL JOURNAL
[Internet]

ストレスからの防御は夜は弱い　　　　　　　　　　　　　　　
Dec. 2018
NHK さっぽろ
NHK 北海道のニュース
[Media report]

Feeling Stressed At Night Takes A Big Toll On Your Body, Study Shows, So Here's How To Relax　　　　　　　　　　　　　　　
30 Nov. 2018
Other than myself
elite daily
[Internet]

We May Be More Vulnerable to Stress in the Evening　　　　　　　　　　　　　　　
29 Nov. 2018
Other than myself
PsychCentral
[Internet]

北海道大学、ストレス反応が朝と夜で異なる仕組みを解明～現代社会におけるストレスマネジメントへの応用に期待～　　　　　　　　　　　　　　　
29 Nov. 2018
日経バイオテクONLINE
[Internet]

Beware of Evening Stress　　　　　　　　　　　　　　　
28 Nov. 2018
Other than myself
LabManager
[Internet]

Night Stress Is Different From Morning Stress, A New Study Shows, But Here’s The Best Way To Handle It　　　　　　　　　　　　　　　
28 Nov. 2018
Other than myself
Bustle
[Internet]

Your body may not cope with evening stress: Study　　　　　　　　　　　　　　　
28 Nov. 2018
Other than myself
NewKerala.com
[Internet]

Evening Stress: Good or Bad?　　　　　　　　　　　　　　　
27 Nov. 2018
Other than myself
Medindia
[Internet]

Study suggests possible vulnerability to evening stress　　　　　　　　　　　　　　　
27 Nov. 2018
News-Medical.Net
[Internet]

Beware of evening stress　　　　　　　　　　　　　　　
26 Nov. 2018
AlphaGalileo
[Internet]

Beware of evening stress　　　　　　　　　　　　　　　
26 Nov. 2018
the American Association for the Advancement of Science (AAAS)
EurekAlert!
[Internet]

医食同源 必須栄養素自ら判断　　　　　　　　　　　　　　　
14 Dec. 2017
北海道新聞
[Paper]

上手に眠って健康に！快眠の新常識　　　　　　　　　　　　　　　
19 Sep. 2017
STV
どさんんこワイド179
[Media report]

光と運動で時差ぼけ解消
Sep. 2014
北海道医療新聞
13080619, [Paper]

光の下での運動は生体リズムを調節
10 Jul. 2014
JST科学技術振興機構
Science Portal サイエンスポータル
13080619, [Internet]

北大、「明るい光＋運動」が時差ボケ解消に有効であることを明らかに
09 Jul. 2014
財経新聞
13080619, [Internet]

光と運動による生体リズム調節のメカニズム
Jul. 2014
Other than myself
北海道医療新聞
13080619, [Paper]