Yamanaka Yujiro

Faculty of Education　Education　Science of Health and Physical EducationAssociate Professor
Last Updated :2025/11/06

■Researcher basic information

Researchmap personal page

Home Page URL

Researcher number

  • 20528343

J-Global ID

Research Keyword

  • 体内時計
  • 生物時計
  • 身体運動
  • 生体リズム
  • 時計遺伝子
  • 生物発光
  • 環境生理
  • 時差ボケ
  • マウス
  • スポーツ科学
  • スポーツ生理学
  • リズム同調
  • メラトニン
  • システム
  • 行動リズム
  • 睡眠

Research Field

  • Life sciences, Neuroscience - general
  • Life sciences, Nutrition and health science
  • Life sciences, Sports science
  • Life sciences, Physiology, 睡眠科学
  • Life sciences, Physiology, Chronobiology

Educational Organization

■Career

Career

  • Apr. 2018 - Present
    北海道大学健康科学研究教育センター兼務教員
  • Apr. 2016 - Present
    Hokkaido University, Research and Education Center for Brain Science, 基幹教員(兼任)
  • Apr. 2016 - Present
    Hokkaido University, Faculty of Education, 准教授
  • May 2010 - Mar. 2016
    Hokkaido University, 医学(系)研究科(研究院), 助教
  • Apr. 2009 - Apr. 2010
    Hokkaido University, 医学(系)研究科(研究院), 特任助教
  • Jul. 2008 - Mar. 2009
    Hokkaido University, 医学(系)研究科(研究院), 博士研究員

Educational Background

  • Apr. 2004 - Jun. 2008, 北海道大学大学院, 医学研究科, 生体機能学専攻

Committee Memberships

  • Aug. 2024 - Present
    日本睡眠学会, 睡眠ヘルスケアサービスの機能評価に関するワーキンググループ 委員, Society
  • Jan. 2024 - Present
    Asian Sleep Research Society (ASRS), Secretary General, Society
  • Apr. 2022 - Present
    日本睡眠学会, 将来構想委員会 委員, Society
  • Aug. 2021 - Present
    日本睡眠学会, 評議員
  • Apr. 2015 - Present
    日本生理学会, 評議員, Society
  • Apr. 2010 - Present
    日本時間生物学会, 評議員, Society

■Research activity information

Awards

  • Oct. 2025, 北海道大学, 全学教育科目に係る授業アンケートにおけるベスト・エクセレント・ティーチャーズ　　　　　　　　　　　　　　　
  • Aug. 2023, 北海道大学, 北海道大学全学教育科目授業アンケートにおけるエクセレント・ティーチャーズ　　　　　　　　　　　　　　　
  • Aug. 2022, 北海道大学, 北海道大学全学教育科目授業アンケートにおけるエクセレント・ティーチャーズ　　　　　　　　　　　　　　　
  • Aug. 2021, 北海道大学, 全学教育科目に係る授業アンケートにおけるエクセレントティーチャーズ　　　　　　　　　　　　　　　
  • Oct. 2019, 日本神経精神薬理学会, Neuropsychopharmacology Reports (NPPR) Topic Award 2019　　　　　　　　　　　　　　　
    山仲勇二郎
  • Oct. 2019, 日本神経精神薬理学会, Neuropsychopharmacology Reports (NPPR) Article Award 2019　　　　　　　　　　　　　　　
    山仲勇二郎
  • Nov. 2017, 国立研究開発法人 科学技術振興機構（JST), COI2021 表彰特別賞　　　　　　　　　　　　　　　
    山仲勇二郎
  • Jul. 2015, 北海道大学医学部医学科, 平成26年度エクセレント・ティーチャー(優秀賞）　　　　　　　　　　　　　　　
    山仲勇二郎
  • Nov. 2014, 日本時間生物学学会, 日本時間生物学会学術奨励賞　　　　　　　　　　　　　　　
    山仲勇二郎
  • Jul. 2014, 北海道大学医学部医学科, 平成25年度優秀教員賞　　　　　　　　　　　　　　　
    山仲勇二郎
  • Nov. 2013, 第20回日本時間生物学会学術大会優秀ポスター賞　　　　　　　　　　　　　　　
    山仲勇二郎
  • Mar. 2012, 日本生理学会環境生理学グループ久野寧記念賞　　　　　　　　　　　　　　　
    山仲勇二郎

Papers

  • Nonphotic Entrainment and Phase-Shifting of Circadian Rhythms by Novelty-Induced Wheel Running in Female Mice.
    Ren Y Sato, Yujiro Yamanaka
    American journal of physiology. Regulatory, integrative and comparative physiology, 20 Oct. 2025, [International Magazine]
    English, Scientific journal, Environmental light-dark (LD) cycles serve as the primary zeitgeber for the mammalian circadian system, but scheduled physical activity such as voluntary wheel running can act as a potent nonphotic cue. Previous studies on nonphotic entrainment have predominantly used male animals, leaving sex-specific mechanisms largely unexplored. In this study, we investigated circadian behavioral entrainment and phase-shifting responses to scheduled wheel-running activity in female C57BL/6J mice under constant darkness (DD). Mice underwent scheduled daily exposure to a novel cage with a running wheel (NCRW) for 3 hours, and spontaneous locomotor rhythms were analyzed before, during, and after exposure. Fifteen of 16 female mice achieved steady-state entrainment when the NCRW schedule coincided with activity onset. However, they lacked both anticipatory behavior and behavioral after-effects of entrainment-defined as persistent changes in circadian period and activity timing following entrainment-unlike what has been previously reported in males. To interpret entrainment dynamics, we constructed phase response curve (PRC) for a single 3-hour pulse of exposure to NCRW in both sexes. Female PRC displayed prominent delay portions in the late subjective day and early subjective night, contrasting with male profiles showing minor advances in the same windows. These findings reveal a sex difference in nonphotic circadian entrainment and suggest that underlying mechanisms, including oscillator coupling or differential sensitivity to nonphotic stimuli, may vary between males and females. The results emphasize the importance of considering biological sex in circadian research and provide a basis for further investigation into sex-specific regulation of behavioral rhythms.
  • Circadian Phase Assessment of Core Body Temperature Using a Wearable Temperature Sensor Under the Real World.
    Naoko Kubota, Kazufumi Okada, Yujiro Yamanaka
    Sleep science (Sao Paulo, Brazil), 18, 3, e246-e252, Sep. 2025, [International Magazine]
    English, Scientific journal, OBJECTIVE: To evaluate whether a patch-type wearable temperature sensor (CALERA Research) could determine the circadian phase of core body temperature (CBT) in a manner like a rectal probe. OBJECTIVE: Sixteen participants (27 ± 11 years, 8 males and 8 females) wore an actigraph and CALERA Research sensor on the chest region for 3-5 days in a real-world setting. Simultaneous rectal temperature measurements were performed during the nocturnal sleep period. The midpoints of the nocturnal decrease in CBT (CBT trough ) were used as the circadian phase marker. We analyzed 60 pairs of CBT trough . The reliability and agreement of the CBT trough from the two devices were analyzed using the intraclass correlation coefficient (ICC) and the concordance correlation coefficient (CCC). The Bland-Altman analysis was used to quantify the limit of agreement of CBT trough between the devices. OBJECTIVE: The ICC of 0.96 (95%CI: 0.93-0.98) and CCC of 0.96 (95%CI: 0.93-0.97) values indicated excellent reliability and substantial agreement, respectively. The mean bias was 0.16 hours (95%LoA: -0.76-1.07 hours). The mean CBT trough comparison was 5.9 ± 1.6 hours in the CALERA Research sensor and 5.8 ± 1.7 hours in the rectal probe. CONCLUSION: The difference in the CBT trough between the two devices was about ± 1.0 hour which would be an acceptable range for determining the CBT trough . We suggest that the CALERA Research sensor could be a useful tool for reasonably estimating the circadian phase of CBT trough and providing a surrogate for a rectal probe.
  • Blue Light-Blocking Glasses Attenuate Light-Induced Melatonin Suppression in Healthy Japanese Adults.
    Yuma Onodera, Naoko Kubota, Nagomi Miyagi, Noriko Matsuura, Shinya Muramatsu, Yuji Kato, Yujiro Yamanaka
    The Tohoku journal of experimental medicine, 03 Jul. 2025, [Domestic magazines]
    English, Scientific journal
  • Variety of sleep and circadian rhythms of elderly dementia patients living in group home residences.
    Naoko Kubota, Noriko Matsuura, Maiko Ebina, Hitomi Suzuki, Nagomi Miyagi, Naoki Masukawa, Fumihiro Kouga, Yujiro Yamanaka
    Biogerontology, 26, 4, 131, 131, 27 Jun. 2025, [International Magazine]
    English, Scientific journal, In the present study, we investigated 70 elderly individuals with dementia residing in a group home in Japan (88.1 ± 6.6 SD years; 12 males and 58 females). Sleep measurements were collected via an accelerometer placed under the mattress from March 2021 to January 2024. The accelerometer-derived activity counts were transformed and plotted as actograms. On the basis of the actograms, sleep patterns were categorized into three groups: regular nighttime sleep (Type 1, n = 38, 54.3%), regular nighttime sleep with daytime naps (Type 2, n = 29, 41.4%), and irregular sleep (Type 3, n = 3, 4.3%). We compared accelerometer-derived sleep measures between the Type 1 and Type 2 groups due to the small number of participants in Type 3. Interestingly, Type 2 individuals had a significantly longer bed in time and total sleep time. However, their sleep onset latency, time of wakefulness after sleep onset and sleep efficiency did not differ from those of Type 1 individuals. Additionally, we assessed the relationships between sleep patterns and dementia characteristics, such as independence in daily living and level of care needed. No significant differences were observed in sleep measurements across these characteristics. To evaluate endogenous circadian rhythms, seven dementia patients (Type 1, n = 1; Type 2, n = 6) wore a patch-type wearable temperature sensor for approximately 24 h to estimate core body temperature (CBT). Although the zero-amplitude test revealed a significant rhythmicity in all patients, the CBT rhythms showed lower amplitude and unstable phases. In summary, our findings indicate that dementia patients display varying sleep patterns that are independent of dementia characteristics. The dysfunction of sleep homeostasis and entrainment of circadian pacemakers might be due to the light environment in the group home residence or impairment of the circadian clock itself in dementia patients.
  • Two oscillatory components detected by forced splitting of the sleep-wake cycle in humans.
    Satoko Hashimoto, Takuro Endo, Sato Honma, Yujiro Yamanaka, Ken-Ichi Honma
    American journal of physiology. Regulatory, integrative and comparative physiology, 326, 1, R19-R28, 01 Jan. 2024, [International Magazine]
    English, Scientific journal, The sleep-wake cycle of human subjects was artificially split into two episodes by imposing an 8-h light and 4-h dark cycle (LD 8:4) twice a day for 7 days, which was followed by a 3-day free-running session. Sleep was permitted only in the dark period. The subjects in the ordinary group were exposed to ordinary light (ca. 500 lx) in the 8-h light period, and those in the bright light group to bright (ca. 5,000 lx) and ordinary light alternatively with bright light after the first dark period (2400-400). Split sleeps persisted in the free-running session with the major episode around the first dark period and the minor episode around the second dark period. By contrast, circadian melatonin rhythm in the free-running session significantly phase delayed in the ordinary light group, but phase advanced in the bright light group, keeping the melatonin rhythm unsplit. The length of nocturnal melatonin secretion (NMS) was significantly shortened in the bright light group. Interestingly, the falling phase of NMS advanced significantly further than the rising phase. Such a difference was not detected in the ordinary light group. Similar differences were observed in the body temperature rhythm. These findings indicated oscillatory mechanisms underlying split sleeps distinct from the circadian pacemaker and suggested an involvement of different circadian oscillators in the rising and falling phases of NMS, which is consistent with the dual oscillator model proposed for the circadian system of nocturnal rodents.NEW & NOTEWORTHY The present study demonstrated that human sleep was separated into two essentially identical components, which persisted under constant conditions, suggesting circadian oscillator underlying split-sleep episodes. The study also indicated differential light sensitivities in the rising and falling phases of circadian melatonin rhythm, indicating the involvement of two different oscillators. These results consisted of the evening and morning dual-oscillator hypothesis for the circadian pacemaker and the hierarchical model for the pacemaker and sleep-wake cycle.
  • Differential responses to artificial photoperiods of the rising and falling phases of human melatonin rhythm are consistent with a dual oscillator hypothesis.
    Satoko Hashimoto, Takuro Endo, Sato Honma, Yujiro Yamanaka, Ken-Ichi Honma
    American journal of physiology. Regulatory, integrative and comparative physiology, 325, 5, R619-R628, 01 Nov. 2023, [International Magazine]
    English, Scientific journal, Circadian rhythms and sleep-wake cycles were measured in volunteers staying singly in temporal isolation unit where they were exposed to artificial short and long light-dark (LD) cycles for 7 days. The long day consisted of 16-h light and 8-h dark (LD 16:8) and the short day consisted of 8-h light and 16-h dark (LD 8:16). During the light period, bright light of approximately 5,000 lux was given from the ceiling and during the dark period there was no illumination. Sleep was monitored by bed sensors, wrist actiwatch, and polysomnography (PSG) on the first and last nights of the schedule. Sleep length was significantly longer under LD 8:16 than under LD 16:8 and the sleep quality estimated by PSG was worse under LD 8:16 than under LD 16:8, which were comparable to natural seasonality in sleep. The circadian rhythm in plasma melatonin was measured in dim light (10 lux) before and after the LD exposures. The nocturnal melatonin secretion (NMS) was significantly longer after LD 8:16 than after LD 16:8 due to differential phase shifts of the rising and falling phases of NMS. After LD 8:16, the falling phase was much advanced than the rising phase, whereas after LD 16:8 the rising phase was much delayed than the falling phase, resulting in the NMS compression. These results indicate that the light sensitivity in terms of phase shifting is different in the two circadian phases, supporting a dual oscillator hypothesis with different phase-response curves for light in the human circadian system.NEW & NOTEWORTHY The present study demonstrated differential light responsiveness of the rising and falling phases of nocturnal melatonin secretion in human subjects exposed to artificial long (LD 16:8) and short days (LD 8:16) and suggested the involvement of different oscillators under these phases. The findings well mimicked the seasonality of the circadian rhythms in nature and consisted with the evening/morning dual oscillator hypothesis proposed originally for nocturnal rodents, providing a new concept for the human circadian system.
  • Nonphotic entrainment of central and peripheral circadian clocks in mice by scheduled voluntary exercise under constant darkness.
    Ren Y Sato, Yujiro Yamanaka
    American journal of physiology. Regulatory, integrative and comparative physiology, 20 Feb. 2023, [International Magazine]
    English, Scientific journal, In mammals, the central circadian pacemaker in the suprachiasmatic nucleus (SCN) entrains to an environmental light-dark (LD) cycle and organizes the temporal order of circadian rhythms in physiology and behavior. Previously, some studies have demonstrated that scheduled exercise could entrain the free-running behavior rhythm in nocturnal rodents. However, it remains unknown whether entrainment by scheduled exercise alters the internal temporal order of the behavioral circadian rhythms or clock gene expression in the SCN, extra-SCN brain regions, and peripheral organs when mice are entrained to the scheduled exercise under constant darkness (DD). In the present study, we examined circadian rhythms in locomotor activity and Per1-luc rhythms in the SCN, arcuate nucleus (ARC), liver, and skeletal muscle of mice entrained to an LD, mice free-running under DD and mice entrained to daily exposure to a new cage with a running wheel (NCRW) under DD. All mice showed a steady-state entrainment of behavioral circadian rhythms to NCRW exposure under DD in parallel with shortening the alpha when compared to that under DD. The temporal order of behavioral circadian rhythms and the Per1-luc rhythms in the SCN and peripheral tissues but not in the ARC were maintained in the mice entrained to the NCRW and LD cycles; in contrast, the temporal order was altered in the mice under DD. The present findings reveal that the SCN entrains to daily exercise, and daily exercise reorganizes the internal temporal order of behavioral circadian rhythms and clock gene expression in the SCN and peripheral tissues.
  • [Impacts of mastication frequency on circadian rhythm of glucose metabolism].
    Yujiro Yamanaka
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 158, 2, 165, 168, 2023, [Domestic magazines]
    Japanese, Scientific journal, Postprandial glucose concentration is dependent on the time of day and its concentration in the morning is lower than in the evening. The circadian rhythm of glucose metabolism is regulated by the central circadian pacemaker in the suprachiasmatic nucleus (SCN). Both the SCN circadian clock and the pancreatic clock play important role in generating and maintaining the circadian rhythm of glucose metabolism. Also, short sleep duration and circadian misalignment are closely associated with a decrease in insulin sensitivity and an increase in type2 diabetes. Increased frequency of mastication and/or thorough chewing has been reported to alter the secretion of hormones related to appetite and energy metabolism. Furthermore, we have reported that the effect of mastication on postprandial glucose metabolism is dependent on the time of day and frequency of mastication. Morning mastication but not evening decreases postprandial blood glucose concentrations and increases insulin secretion at 30 min and so-called the insulinogenic index as a marker of early-phase β-cell function. This novel finding may aid in reducing the incidence of obesity and type 2 diabetes mellitus. This review covers the basic concept of the mammalian human circadian system, the underlying mechanism causing phase adjustment of the circadian rhythms in the SCN and peripheral organs, and the effect of eating behavior (e.g., chewing frequency) on the circadian rhythm of glucose metabolism.
  • Time of Day of Vaccination Does Not Associate With SARS-CoV-2 Antibody Titer Following First Dose of mRNA COVID-19 Vaccine.
    Yujiro Yamanaka, Isao Yokota, Atsushi Yasumoto, Eriko Morishita, Hisanori Horiuchi
    Journal of biological rhythms, 37, 6, 7487304221124661, 7487304221124661, 26 Sep. 2022, [International Magazine]
    English, The immune system exhibits circadian rhythms, and its response to viral infection is influenced by the circadian clock system. Previous studies have reported associations between the time of day of vaccination against COVID-19 and production of anti-SARS-CoV-2 antibody titer. We examined the effect of vaccination time of day on anti-SARS-CoV-2 antibody titer after the first dose of vaccination with the mRNA-1273 (Moderna) COVID-19 vaccine in an adult population. A total of 332 Japanese adults participated in the present study. All participants were not infected with SARS-CoV-2 and had already received the first dose of mRNA-1273 2 to 4 weeks prior to participating in the study. The participants were asked to provide basic demographic characteristics (age, sex, medical history, allergy, medication, and mean sleep duration), the number of days after the first dose of vaccination, and the time of day of vaccination. Blood was collected from the participants, and SARS-CoV-2 antibody titers were measured. Ordinary least square regression was used for assessing the relationship between basic demographic characteristics, number of days after vaccination, time of day of vaccination, and the log10-transformed normalized antibody titer. The least square mean of antibody titers was not associated with the vaccination time and sleep durations. The least square means of antibody titers was associated with age; the antibody titers decreased in people aged 50 to 59 years and 60 to 64 years. The present findings demonstrate that the vaccination time with mRNA-1273 was not associated with the SARS-CoV-2 antibody titer in an adult population, suggesting that these results do not support restricting vaccination to a particular time of day. The present findings may be useful in optimizing SARS-CoV-2 vaccination strategies.
  • Correction to: Effects of Lactococcus lactis subsp. cremoris YRC3780 daily intake on the HPA axis response to acute psychological stress in healthy Japanese men.
    Noriko Matsuura, Hidemasa Motoshima, Kenji Uchida, Yujiro Yamanaka
    European journal of clinical nutrition, 10 May 2022, [International Magazine]
    English
  • A fixed single meal in the subjective day prevents free-running of the human sleep-wake cycle but not of the circadian pacemaker under temporal isolation.
    Yujiro Yamanaka, Satoko Hashimoto, Aya Honma, Sato Honma, Ken-Ichi Honma
    American journal of physiology. Regulatory, integrative and comparative physiology, 26 Apr. 2022, [Peer-reviewed], [Lead author], [International Magazine]
    English, Scientific journal, Effects of a fixed single meal per day were examined on the circadian pacemaker and sleep-wake cycle in subjects under temporal isolation. When the time of single meal was allowed to take at any time of day (Ad-lib meal), the sleep-wake cycle as well as the circadian rhythms in plasma melatonin, cortisol and core body temperature were significantly phase-delayed in 8 days. On the other hand, when the time of meal was fixed at 1800 h in local time (RF meal), the phase-shift of sleep-wake cycle was not significant, while those of the circadian rhythms were significant. The differential effects of a fixed single meal schedule were confirmed in most individual subjects. There was no evidence for the prefeeding increase in plasma cortisol and leptin levels under the fixed single meal schedule. The plasma ghrelin level was apparently high before meal in both Ad-lib and RF meal groups, which was, however, likely sculptured by a non-specific prandial drop and gradual increase after meal intake. Single meal augmented the prandial increase of plasma insulin levels by 4-5 times. These findings indicate that a single meal at fixed time of day during the subjective day failed to prevent the human circadian pacemaker but prevented the sleep-wake cycle to free-run at least 8 days under temporal isolation, suggesting that meal time was a potent non-photic time cue for the human sleep-wake cycle.
  • Effects of different light incident angles via a head-mounted device on the magnitude of nocturnal melatonin suppression in healthy young subjects　　　　　　　　　　　　　　　
    Naoko Kubota, Yusuke Tamori, Kenkichi Baba, Yujiro Yamanaka
    Sleep and Biological Rhythms, 21 Jan. 2022, [Peer-reviewed], [Corresponding author]
    English, Scientific journal
  • Effects of Lactococcus lactis subsp. cremoris YRC3780 daily intake on the HPA axis response to acute psychological stress in healthy Japanese men
    Noriko Matsuura, Hidemasa Motoshima, Kenji Uchida, Yujiro Yamanaka
    European Journal of Clinical Nutrition, Springer Science and Business Media LLC, 04 Aug. 2021, [Peer-reviewed], [Last author, Corresponding author]
    Scientific journal, Abstract
    Background
    Lactococcus lactis subsp. cremoris (YRC3780), which is isolated from kefir, has been associated with anti-allergic effects in humans. However, it remains unknown whether daily intake of YRC3780 attenuates the response to psychological stress in humans in parallel with changes to the gut microbiome. We examined the fundamental role of YRC3780 in the gut microbiome, stress response, sleep, and mental health in humans.



    Methods
    Effects of daily intake of YRC3780 on the hypothalamic-pituitary-adrenal (HPA) axis response to acute psychological stress were investigated in a double-blind, placebo-controlled clinical trial involving 27 healthy young men (mean age and body mass index: 23.5 years and 21.5 kg/m2) who were randomly assigned to placebo (n = 13) or YRC3780 (n = 14) groups. The HPA axis response to acute psychological stress, the diurnal rhythm of HPA axis activity, and gut microbiome were assessed and compared between the two groups.



    Results
    The results showed that daily intake of YRC3780 significantly lowered morning salivary cortisol levels compared with placebo. In addition, salivary cortisol levels following a social stress test significantly decreased +40 min after beginning the TSST in the YRC3780-treated group compared to placebo. There were no significant differences between the two groups in terms of actigraphy-based sleep quality, but the subjective sleep quality and mental health were significantly improved in the YRC3780-treated group compared to placebo.



    Conclusions
    Our study suggests that daily intake of YRC3780 improves the HPA axis response to acute psychological stress, which might be associated with a decrease in morning cortisol levels.


  • Basic concepts and unique features of human circadian rhythms: implications for human health.
    Yujiro Yamanaka
    Nutrition reviews, 78, Supplement_3, 91, 96, 01 Dec. 2020, [Peer-reviewed], [Invited], [Lead author, Corresponding author], [International Magazine]
    English, Scientific journal, Most physiological functions and behaviors exhibit a robust approximately 24-hour rhythmicity (circadian rhythm) in the real world. These rhythms persist under constant conditions, but the period is slightly longer than 24 hours, suggesting that circadian rhythms are endogenously driven by an internal, self-sustained oscillator. In mammals, including humans, the central circadian pacemaker is located in the hypothalamic suprachiasmatic nucleus. The primary zeitgeber for this pacemaker is bright sunlight, but nonphotic time cues also affect circadian rhythms. The human circadian system uniquely exhibits spontaneous internal desynchronization between the sleep-wake cycle and core body temperature rhythm under constant conditions and partial entrainment of the sleep-wake cycle in response to nonphotic time cues. Experimental and clinical studies of human circadian rhythms must take into account these unique features. This review covers the basic concepts and unique features of the human circadian system, the mechanisms underlying phase adjustment of the circadian rhythms by light and nonphotic time cues (eg, physical exercise), and the effects of eating behavior (eg, chewing frequency) on the circadian rhythm of glucose metabolism.
  • Morning Mastication Enhances Postprandial Glucose Metabolism in Healthy Young Subjects
    Arisa Sato, Yoshinori Ohtsuka, Yujiro Yamanaka
    Tohoku Journal of Experimental Medicine, 249, 3, 193, 201, Nov. 2019, [Peer-reviewed], [Last author, Corresponding author]
    English, Scientific journal, 13081245
  • Hypothalamic-pituitary-adrenal axis differentially responses to morning and evening psychological stress in healthy subjects.
    Yamanaka Y, Motoshima H, Uchida K
    Neuropsychopharmacology reports, 39, 1, 41, 47, Mar. 2019, [Peer-reviewed], [Lead author, Corresponding author]
  • Cryptochrome deficiency enhances transcription but reduces protein levels of pineal Aanat
    Yamanaka Y, Yamada Y, Honma KI, Honma S
    Journal of molecular endocrinology, 61, 4, 219, 229, Oct. 2018, [Peer-reviewed], [Lead author]
  • Two Coupled Circadian Oscillators Are Involved in Nonphotic Acceleration of Reentrainment to Shifted Light Cycles in Mice.
    Yamanaka Y, Honma S, Honma KI
    Journal of biological rhythms, 33, 6, 748730418796300, 625, Sep. 2018, [Peer-reviewed], [Lead author]
  • Phase-adjustment of human circadian rhythms by light and physical exercise.
    Yamanaka Y, Waterhouse J
    The Journal of Physical Fitness and Sports Medicine, 5, 4, 287, 299, 03 Oct. 2016, [Peer-reviewed], [Invited], [Lead author, Corresponding author]
  • Mistimed wheel running interferes with re-entrainment of circadian Per1 rhythms in the mouse skeletal muscle and lung
    Yujiro Yamanaka, Sato Honma, Ken-ichi Honma
    GENES TO CELLS, 21, 3, 264, 274, Mar. 2016, [Peer-reviewed], [Lead author]
    English, Scientific journal
  • Morning and evening physical exercise differentially regulate the autonomic nervous system during nocturnal sleep in humans
    Yujiro Yamanaka, Satoko Hashimoto, Nana N. Takasu, Yusuke Tanahashi, Shin-ya Nishide, Sato Honma, Ken-ichi Honma
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 309, 9, R1112, R1121, Nov. 2015, [Peer-reviewed], [Lead author]
    English, Scientific journal
  • 食事時刻がヒトの生体リズムおよびエネルギー代謝調節に与える影響
    山仲 勇二郎, 橋本 聡子, 山田 淑子, 本間 研一
    デサントスポーツ科学, 36, 50, 60, (公財)石本記念デサントスポーツ科学振興財団, Jun. 2015, [Peer-reviewed], [Lead author]
    Japanese
  • Differential regulation of circadian melatonin rhythm and sleep-wake cycle by bright lights and nonphotic time cues in humans
    Yujiro Yamanaka, Satoko Hashimoto, Satoru Masubuchi, Akiyo Natsubori, Shin-ya Nishide, Sato Honma, Ken-ichi Honma
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 307, 5, R546, R557, Sep. 2014, [Peer-reviewed]
    English, Scientific journal
  • Daily exposure to a running wheel entrains circadian rhythms in mice in parallel with development of an increase in spontaneous movement prior to running-wheel access
    Yujiro Yamanaka, Sato Honma, Ken-ichi Honma
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 305, 11, R1367, R1375, Dec. 2013, [Peer-reviewed]
    English, Scientific journal
  • 低温暴露による新生ラットの概日時計の位相シフト.
    吉川朋子, 松野亜美, 山仲勇二郎, 西出真也, 本間さと, 本間研一
    北海道医誌, 88, 2, 89, 89, Apr. 2013
    Japanese, Research institution
  • Daily exposure to cold phase-shifts the circadian clock of neonatal rats in vivo
    Tomoko Yoshikawa, Ami Matsuno, Yujiro Yamanaka, Shin-ya Nishide, Sato Honma, Ken-ichi Honma
    European Journal of Neuroscience, 37, 3, 491, 497, 3, Feb. 2013, [Peer-reviewed]
    English, Scientific journal
  • Loss of circadian rhythm and light-induced suppression of pineal melatonin levels in Cry1 and Cry2 double-deficient mice
    Yujiro Yamanaka, Yohko Suzuki, Takeshi Todo, Ken-ichi Honma, Sato Honma
    GENES TO CELLS, 15, 10, 1063, 1071, Oct. 2010, [Peer-reviewed], [Lead author]
    English, Scientific journal
  • Physical exercise accelerates reentrainment of human sleep-wake cycle but not of plasma melatonin rhythm to 8-h phase-advanced sleep schedule
    Yujiro Yamanaka, Satoko Hashimoto, Yusuke Tanahashi, Shin-ya Nishide, Sato Honma, Ken-ichi Honma
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 298, 3, R681, R691, Mar. 2010, [Peer-reviewed]
    English, Scientific journal
  • [Daily phase adjustment of human sleep-wake cycle]
    Yamanaka Y, Honma S, Honma K
    Nippon rinsho. Japanese journal of clinical medicine, 67, 8, 1475, 1482, 8, Aug. 2009, [Peer-reviewed]
  • Scheduled exposures to a novel environment with a running-wheel differentially accelerate re-entrainment of mice peripheral clocks to new light-dark cycles
    Yujiro Yamanaka, Sato Honma, Ken-Ichi Honma
    Genes to Cells, 13, 5, 497, 507, 5, May 2008, [Peer-reviewed]
    English, Scientific journal
  • Scheduled exposures to a novel environment with a running-wheel differentially accelerate re-entrainment of mice peripheral clocks to new light-dark cycles
    Yujiro Yamanaka, Sato Honma, Ken-ichi Honma
    GENES TO CELLS, 13, 5, 497, 507, May 2008, [Peer-reviewed]
    English, Scientific journal
  • Repeated exposures to daytime bright light increase nocturnal melatonin rise and maintain circadian phase in young subjects under fixed sleep schedule
    Nana N. Takasu, Satoko Hashimoto, Yujiro Yamanaka, Yusuke Tanahashi, Ayano Yamazaki, Sato Honma, Ken-ichi Honma
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 291, 6, R1799, R1807, Dec. 2006, [Peer-reviewed]
    English, Scientific journal
  • Effects of physical exercise on human circadian rhythms
    Yamanaka Yujiro, Honma Ken-ichi, Hashimoto Satoko, Takasu Nana, Miyazaki Toshihiko, Honma Sato
    Sleep and Biological Rhythms, 4, 3, 199, 206, Jul. 2006, [Peer-reviewed]
    English, Scientific journal
  • Cardiovascular autonomic nervous response to postural change in 610 healthy Japanese subjects in relation to age
    Y Yamanaka, K Honma
    AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 124, 1-2, 125, 131, Jan. 2006, [Peer-reviewed]
    English, Scientific journal
  • ヒトサーカディアンリズム振幅に与える光の影響について
    高須 奈々, 橋本 聡子, 山仲 勇二郎, 本間 さと, 本間 研一
    日本生理学雑誌, 67, 12, 403, 403, (一社)日本生理学会, Dec. 2005
    Japanese

Other Activities and Achievements

Books and other publications

  • 子どもの睡眠ガイドブック : 眠りの発達と睡眠障害の理解
    駒田, 陽子, 井上, 雄一
    朝倉書店, 2019, 9784254301199, viii, 173p, Japanese
  • 睡眠学I : 「眠り」の科学入門　　　　　　　　　　　　　　　
    宮崎総一郎, 北浜邦夫, 井上昌次郎, 林光男, 山仲勇二郎, 松浦倫子, 第7章 生体リズムと睡眠
    北大路書房, Nov. 2018, [Joint work]
  • ヒトの生物時計制御と光環境　　　　　　　　　　　　　　　
    山仲勇二郎, 第3章 光の情報利用
    朝倉書店, 25 Feb. 2016, 9784254171617, 422, 224-225, Japanese, [Contributor]
  • 脳とこころのプライマリケア第5巻 意識と睡眠　　　　　　　　　　　　　　　
    山仲勇二郎, 本間さと, 本間研一, 生物時計に関わる神経系
    株式会社シナジー, Jun. 2012, 9784916166296, 864, 313-316, Japanese, [Contributor]
  • 体内時計の科学と産業応用　　　　　　　　　　　　　　　
    山仲勇二郎, 本間さと, 体内時計の生理機能
    シーエムシー出版, May 2011, 9784781303406, 253, 11-19, Japanese, [Contributor]
  • からだと温度の事典　　　　　　　　　　　　　　　
    山仲勇二郎, 本間さと, 本間研一, 体温リズムの異常
    朝倉書店, Apr. 2010, 9784254301021, 640, 139-142, Japanese, Dictionary or encycropedia, [Contributor]

Lectures, oral presentations, etc.

  • 睡眠と体内時計　　　　　　　　　　　　　　　
    山仲勇二郎
    第24回睡眠健康指導士上級講座, 21 Nov. 2020, Public discourse
    21 Nov. 2020 - 21 Nov. 2020, [Invited]
  • 知って得する「睡眠」のチカラ！　　　　　　　　　　　　　　　
    山仲勇二郎
    令和2年度夕張市市民健康講座, 13 Oct. 2020, Public discourse
    13 Oct. 2020 - 13 Oct. 2020, [Invited]
  • 質の良い眠りとは～睡眠のウソ・ホント～　　　　　　　　　　　　　　　
    山仲勇二郎
    令和2年度第2期えるのす連続講座～女性大学～, 30 Sep. 2020, Public discourse
    30 Sep. 2020 - 30 Sep. 2020, [Invited]
  • Effect of non-photic zeitgebers on circadian rhythm and sleep-wake cycle in humans　　　　　　　　　　　　　　　
    山仲勇二郎, 橋本聡子, 本間あや, 本間さと, 本間研一
    第27回日本時間生物学会学術大会, 26 Sep. 2020
    26 Sep. 2020 - 27 Sep. 2020, [Invited]
  • 運動や食事が睡眠・生体リズムに与える影響　　　　　　　　　　　　　　　
    山仲勇二郎
    第1回札幌睡眠フォーラム, Nominated symposium
    09 Nov. 2019, [Invited]
  • ぐっすり眠って健康に～すぐに実践できる睡眠改善法～　　　　　　　　　　　　　　　
    山仲勇二郎
    佐呂間町働き盛り世代の健康づくり講演会, Public discourse
    08 Nov. 2019, [Invited]
  • Effect of mastication on glucose metabolism after high carbohydrate food consumption depends on the number of chew and time of day in healthy subjects　　　　　　　　　　　　　　　
    Yujiro Yamanaka, Arisa Sato, Yoshinori Ohtsuka
    第26回日本時間生物学会学術大会, 12 Oct. 2019, Poster presentation
    12 Oct. 2019 - 13 Oct. 2019
  • Chronobiology: Circadian clock and circadian rhythms in humans
    Yujiro Yamanaka
    ILSI Japan第8回「栄養とエイジング」国際会議, 02 Oct. 2019, English, Nominated symposium
    01 Oct. 2019 - 02 Oct. 2019, 13081245, [Invited]
  • ヒト生物時計の特性を考慮した生体リズム調整法と実践例
    山仲勇二郎, Jim Waterhouse
    第74回日本体力医学会大会, 20 Sep. 2019, Nominated symposium
    19 Sep. 2019 - 21 Sep. 2019, 25940757, [Invited]
  • 社会的因子が生物時計と睡眠に与える影響～ヒト生物時計の2振動体モデルから睡眠に適した生活リズムを考える～　　　　　　　　　　　　　　　
    山仲勇二郎
    第28回日本睡眠環境学会学術大会学術大会, 06 Sep. 2019, Nominated symposium
    05 Sep. 2019 - 06 Sep. 2019, [Invited]
  • 睡眠環境の重要性とアプリを用いた睡眠マネジメントの試み　　　　　　　　　　　　　　　
    松浦倫子, 田中秀樹, 山仲勇二郎.
    第28回日本睡眠環境学会学術大会学術大会, 06 Sep. 2019, Nominated symposium
    05 Sep. 2019 - 06 Sep. 2019
  • 睡眠のウソ？ホント？ぐっすり眠るために大切なこと　　　　　　　　　　　　　　　
    山仲勇二郎
    精神神経科学センター平成31年度学校訪問型睡眠講座事業, Public discourse
    10 Jun. 2019, [Invited]
  • 健康と深い関わりをもつ生物時計のふしぎ-すぐに実践できる生物時計の調整法を伝授します-　　　　　　　　　　　　　　　
    山仲勇二郎
    第61回北大祭公開講義, Japanese, Public discourse
    08 Jun. 2019, [Invited]
  • こころの健康に深く関わる睡眠・生体リズムの仕組み　　　　　　　　　　　　　　　
    山仲勇二郎
    一般財団法人メンタルケア協会メンタルケア・スペシャリスト養成講座, Japanese, Public discourse
    02 Jun. 2019, [Invited]
  • 生物時計の構造と機能～生体リズムの乱れが心身の健康に与える影響～　　　　　　　　　　　　　　　
    山仲勇二郎
    日本東洋医学会北海道支部2019年度第1回教育講演会, Japanese, Nominated symposium
    25 May 2019, [Invited]
  • 生体リズムと健康の深い関わり　　　　　　　　　　　　　　　
    山仲勇二郎
    全国保険協会（協会けんぽ）北海道支部と株式会社フィリップスの健康づくりの推進に向けた包括的相互連携に関する協定締結式, Japanese, Invited oral presentation
    26 Feb. 2019, [Invited]
  • 体内時計と健康のメカニズム　　　　　　　　　　　　　　　
    山仲勇二郎
    北海道庁 平成30年度生活習慣病予防セミナー, 01 Feb. 2019, Japanese, Public discourse
    [Invited], [Domestic Conference]
  • 日の当たる朝で素敵な1日を　　　　　　　　　　　　　　　
    山仲勇二郎
    北海道大学COI『食と健康の達人』拠点シンポジウム２０１８, 11 Jan. 2019, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • 生物時計を考慮した健康的な生活リズムを デザインするための基盤研究　　　　　　　　　　　　　　　
    山仲勇二郎
    2018年度日本生理学会北海道地方会総会, 07 Dec. 2018, Japanese, Invited oral presentation
    [Invited], [Domestic Conference]
  • 生物時計を考慮した健康的な生活リズムをデザインするための基盤研究 ～From Laboratory to Field～　　　　　　　　　　　　　　　
    山仲勇二郎
    2018年度第3回CEHS公開セミナー, 26 Nov. 2018, Japanese, Public discourse
    [Invited], [Domestic Conference]
  • 時間生物学を応用した効果的な運動・食事療法〜心リハへの適用の可能性を探る〜　　　　　　　　　　　　　　　
    山仲勇二郎
    第3回日本心臓リハビリテーション学会北海道支部地方会, 24 Nov. 2018, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • ヒト生物時計の調節機序と未解決問題　　　　　　　　　　　　　　　
    山仲勇二郎
    ヒューマンカロリーメーター協議会, 18 Nov. 2018, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • 光と運動による生体リズムの調節機序　　　　　　　　　　　　　　　
    山仲勇二郎
    睡眠障害WEB Seminar, 08 Nov. 2018, Japanese, Public discourse
    [Invited], [Domestic Conference]
  • 生物時計を考慮した健康的な生活リズムをデザインするための基盤研究　　　　　　　　　　　　　　　
    山仲勇二郎
    第1回COI学会, 26 Oct. 2018, Japanese, Oral presentation
    [Domestic Conference]
  • Circadian rhythm of salivary cortisol is associated with the HPA axis activity in response to acute psychological stress in healthy subjects　　　　　　　　　　　　　　　
    山仲勇二郎, 元島英雅, 内田健冶
    第25回日本時間生物学会学術大会, 21 Oct. 2018, Japanese, Poster presentation
    [Domestic Conference]
  • Effect of seasonal changes in circadian rhythm on glucose metabolism under normal living condition in healthy young subjects　　　　　　　　　　　　　　　
    Chihiro Okuyama, Yujiro Yamanaka
    第25回日本時間生物学会学術大会, 21 Oct. 2018, Japanese, Poster presentation
    [Domestic Conference]
  • 健康に深く関わる生物時計の仕組み　　　　　　　　　　　　　　　
    山仲勇二郎
    北大総合博物館主催土曜市民セミナー北大の研究最前線, 13 Oct. 2018, Japanese, Public discourse
    [Invited], [Domestic Conference]
  • 心理的ストレッサーに対するHPA axisストレス反応の概日リズム　　　　　　　　　　　　　　　
    山仲勇二郎
    第98回北海道医学大会生理系分科会, 06 Oct. 2018, Japanese, Oral presentation
    [Domestic Conference]
  • トップアスリートに知ってほしい睡眠・仮眠の正しい知識　　　　　　　　　　　　　　　
    山仲勇二郎
    平成30年度ウィンタースポーツコンソシアム, 14 Sep. 2018, Japanese, Public discourse
    [Invited], [Domestic Conference]
  • ヒト生物時計の構造と機能　　　　　　　　　　　　　　　
    山仲勇二郎
    2018年度日本生理人類学会夏期セミナー教育講演, 03 Sep. 2018, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • からだにやさしいライフスタイル選択サポートの創造 －生物時計同調と快適睡眠で高める女子学生のＱＯＬ－　　　　　　　　　　　　　　　
    山仲勇二郎, 元池育子
    JSTフェア, 31 Aug. 2018, Japanese, Nominated symposium
    [Domestic Conference]
  • 健康に深く関わる生物時計のふしぎ　　　　　　　　　　　　　　　
    山仲勇二郎
    北海道大学教育学部公開講座2018, 06 Aug. 2018, Japanese, Public discourse
    [Invited], [Domestic Conference]
  • からだにやさしい ライフスタイル選択サポートの創造 －生物時計同調と快適睡眠で高める女子学生のＱＯＬ－　　　　　　　　　　　　　　　
    山仲勇二郎
    2018年度北海道大学COIサイトビジット, 17 Jul. 2018, Japanese, Nominated symposium
    [Domestic Conference]
  • The role of physical exercise in the non-photic entrainment of the circadian system　　　　　　　　　　　　　　　
    Yujiro Yamanaka
    The 9th Congress of Asian Sleep Research Society（ASRS）, 12 Jul. 2018, English, Invited oral presentation
    [International presentation]
  • 睡眠は健康の宝物～質のよい眠りとは～　　　　　　　　　　　　　　　
    山仲勇二郎
    道新文化センター1Day講座, 14 Apr. 2018, Japanese, Public discourse
    [Domestic Conference]
  • 生物時計を基盤にした健康支援システムの開発をめざして　　　　　　　　　　　　　　　
    山仲勇二郎
    北大COI参画機関会議, 06 Apr. 2018, Japanese, Invited oral presentation
    [Invited], [Domestic Conference]
  • ぐっすり眠って健康に～睡眠に深く関わる生物時計のふしぎ～　　　　　　　　　　　　　　　
    山仲勇二郎
    ツルハドラッグ健康セミナー, 24 Mar. 2018, Japanese, Public discourse
    [Invited], [Domestic Conference]
  • 時間栄養学を活用した個人に適した食生活をデザインする　　　　　　　　　　　　　　　
    山仲勇二郎
    平成29年度道民研修会 地域の食生活支援を推進するためのスキルアップ研修会, 20 Mar. 2018, Japanese, Public discourse
    [Invited], [Domestic Conference]
  • 生物時計を考慮した健康的な生活リズムをデザインするための基盤研究　　　　　　　　　　　　　　　
    山仲勇二郎
    北大COIセミナー, 19 Jan. 2018, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • 生物時計を考慮した健康的な生活リズムをデザインするための基盤研究　　　　　　　　　　　　　　　
    山仲勇二郎
    第3回COI2021ワークショップ, 22 Nov. 2017, Japanese, Others
    [Domestic Conference]
  • お母さんの生物時計と子供の生物時計のふしぎ　　　　　　　　　　　　　　　
    山仲勇二郎
    北海道大学COI「食と健康の達人」拠点シンポジウム, 21 Nov. 2017, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • 時間生物学から笑顔あふれす社会をめざして　　　　　　　　　　　　　　　
    山仲勇二郎
    COI2021参画機関会議, 20 Nov. 2017, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • 光環境と非光因子が睡眠・生物時計に与える影響～時間生物学からみた宇宙環境下での睡眠・生体リズム調整～　　　　　　　　　　　　　　　
    山仲勇二郎
    第63回日本宇宙航空環境医学会, 17 Nov. 2017, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • 時間生物学と生物時計の不思議　　　　　　　　　　　　　　　
    山仲勇二郎
    平成29年度アクティブラーニング型学問探求セミナー, 15 Nov. 2017, Japanese, Public discourse
    [Invited], [Domestic Conference]
  • 睡眠と時間生物学　　　　　　　　　　　　　　　
    山仲勇二郎
    第15回睡眠健康指導士上級講座, 04 Nov. 2017, Japanese, Public discourse
    [Invited], [Domestic Conference]
  • 双極性障害における概日リズムの内的脱同調　　　　　　　　　　　　　　　
    山仲勇二郎
    第24回日本時間生物学会学術大会, 29 Oct. 2017, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • 時間生物学入門～健康のために知っておきたい生物時計の仕組み～　　　　　　　　　　　　　　　
    山仲勇二郎
    北大セミナーinオホーツク2017, 07 Oct. 2017, Japanese, Public discourse
    [Invited], [Domestic Conference]
  • A novel animal model for Jet lag syndrome　　　　　　　　　　　　　　　
    Yujiro Yamanaka
    ISSR 2017 conference, 22 Sep. 2017, English, Nominated symposium
    [International presentation]
  • 1人1人の体内時計をつくる　　　　　　　　　　　　　　　
    山仲勇二郎
    COI2021 第2回ワークショップ, 15 Sep. 2017, Japanese, Oral presentation
    [Domestic Conference]
  • ねむり上手は健康上手～睡眠・生物時計のふしぎ～　　　　　　　　　　　　　　　
    山仲勇二郎
    道薬検健康セミナー2017, 09 Sep. 2017, Japanese, Public discourse
    [Invited], [Domestic Conference]
  • 運動がヒト生物時計の光反応性に与える影響　　　　　　　　　　　　　　　
    山仲勇二郎
    平成29年度(第50回)照明学会全国大会, 06 Sep. 2017, Japanese, Invited oral presentation
    [Invited], [Domestic Conference]
  • 時間栄養学を実践するために知っておきたい生物時計のしくみ　　　　　　　　　　　　　　　
    山仲勇二郎
    平成29年度中標津保健所管内栄養士会第1回研修会, 14 Jul. 2017, Public discourse
    [Invited], [Domestic Conference]
  • 眠りと健康のふかーい関係～ぐっすり眠るためのコツを伝授します～　　　　　　　　　　　　　　　
    Yujiro Yamanaka
    平成28年度鷹栖町健康づくり講演会, 22 Mar. 2017, Public discourse
    [Invited], [Domestic Conference]
  • 時差対策のアップトゥデイト　　　　　　　　　　　　　　　
    Yujiro Yamanaka
    第60回サッカードクターセミナー, 11 Mar. 2017, Invited oral presentation
    [Invited], [Domestic Conference]
  • 健康な毎日を送るために知っておきたい生物時計の仕組み　　　　　　　　　　　　　　　
    Yujiro Yamanaka
    天使大学2016年度臨地実習に関わる講演会, 19 Feb. 2017, Japanese, Public discourse
    [Invited], [Domestic Conference]
  • Recent advancing the two oscillator model of circadian system in humans　　　　　　　　　　　　　　　
    Yujiro Yamanaka, Satoko Hashimoto, Sato Honma, Ken-ichi Honma
    The 31th Sapporo Symposium on Biological Rhythms, 10 Nov. 2016, English, Nominated symposium
    [Invited], [International presentation]
  • ヒト生物時計の構造と概日リズム制御機構　　　　　　　　　　　　　　　
    Yujiro Yamanaka
    第55回日本生気象学会大会, 05 Nov. 2016, Japanese, Invited oral presentation
    [Invited], [Domestic Conference]
  • Exercise and circadian clock in humans　　　　　　　　　　　　　　　
    Yujiro Yamanaka
    SICEライフエンジニアリング部門シンポジウム2016, 03 Nov. 2016, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • Phase-adjustment of human circadian system by bright light and physical exercise　　　　　　　　　　　　　　　
    Yujiro Yamanaka, Satoko Hashimoto, Sato Honma, Ken-ichi Honma
    The 29th ISC Conference in Suzhou, China, 27 Oct. 2016, English, Nominated symposium
    [Invited], [International presentation]
  • 生物時計の仕組みから子どもの健康を考える　　　　　　　　　　　　　　　
    Yujiro Yamanaka
    第3回子どものからだと心・北海道研究会議, 09 Oct. 2016, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • 生物時計と睡眠～生体リズムを調節し質のよい睡眠を～　　　　　　　　　　　　　　　
    Yujiro Yamanaka
    第8回臨床睡眠医学学会サテライトシンポジウム, 07 Aug. 2016, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • 時間生物学の基礎と体力医学へのメッセージ　　　　　　　　　　　　　　　
    Yujiro Yamanaka
    第18回日本体力医学学会北海道地方会学術集会, 23 Apr. 2016, Japanese, Invited oral presentation
    [Invited], [Domestic Conference]
  • 異なる照明条件下でのでの身体運動がヒト概日リズムの位相変化に与える影響　　　　　　　　　　　　　　　
    山仲勇二郎, 橋本聡子, 増渕悟, 夏堀晃世, 西出真也, 本間さと, 本間研一
    第20回日本時間生物学会学術大会, 09 Nov. 2013, Japanese, Poster presentation
    [Domestic Conference]
  • 高照度光下での身体運動がヒト概日リズムの位相調節に与える影響　　　　　　　　　　　　　　　
    山仲勇二郎, 橋本聡子, 増渕悟, 夏堀晃世, 西出真也, 本間さと, 本間研一
    第90回日本生理学会大会, 29 Mar. 2013, Japanese, Poster presentation
    [Domestic Conference]
  • 明暗周期位相変位後のマウス行動リズムを制御する視交叉上核領域振動体の探索　　　　　　　　　　　　　　　
    山仲勇二郎, 本間さと, 本間研一
    第19回日本時間生物学会学術大会, 15 Sep. 2012, Japanese, Oral presentation
    [Domestic Conference]
  • 1日1食の制限食事がヒトに給餌性リズムを発現させるか
    本間研一, 山仲勇二郎, 橋本聡子, 本間さと
    第19回日本時間生物学会学術大会, 15 Sep. 2012, Japanese, Poster presentation
    [Domestic Conference]
  • 腕時計型行動計により計測されたヒト行動リズムから内的脱同調の有無を判断する　　　　　　　　　　　　　　　
    橋本聡子, 本間研一, 山仲勇二郎, 本間さと
    第19回日本時間生物学会学術大会, 15 Sep. 2012, Japanese, Poster presentation
    [Domestic Conference]
  • 母子同調因子としての環境温: in vivo における視交叉上核の温度感受性　　　　　　　　　　　　　　　
    吉川朋子, 松野亜美, 山仲勇二郎, 西出真也, 本間さと, 本間研一
    第19回日本時間生物学会学術大会, 15 Sep. 2012, Japanese, Public symposium
    [Domestic Conference]
  • 時間隔離実験室を使用したヒト生物時計の非光同調機構の解析　　　　　　　　　　　　　　　
    山仲勇二郎, 橋本聡子, 高須奈々, 棚橋祐典, 西出真也, 本間さと, 本間研一
    第37回日本睡眠学会定期学術集会, 28 Jun. 2012, Japanese, Public symposium
    [Domestic Conference]
  • 運動と生体リズム　　　　　　　　　　　　　　　
    山仲勇二郎, 橋本聡子, 増渕悟, 夏堀晃世, 西出真也, 本間さと, 本間研一
    第37回日本睡眠学会定期学術集会, 28 Jun. 2012, Japanese, Public symposium
    [Domestic Conference]
  • How to measure human circadian rhythms　　　　　　　　　　　　　　　
    Yujiro Yamanaka, Satoko Hashimoto, Sato Honma, Ken-ichi Honma
    International Symposium and Workshop on Frontiers in Sleep and Biological Rhythms Research, 30 Apr. 2012, Japanese, Nominated symposium
    [Domestic Conference]
  • 高照度光下での身体運動がヒト概日リズムの位相調節に与える影響　　　　　　　　　　　　　　　
    山仲勇二郎, 橋本聡子, 増渕悟, 夏堀晃世, 西出真也, 本間さと, 本間研一
    第89回日本生理学会大会, 31 Mar. 2012, Japanese, Poster presentation
    [Domestic Conference]
  • Effect of physical exercise on re-entrainment of human circadian rhythms to an 8 h advanced sleep schedule under bright light coditions　　　　　　　　　　　　　　　
    Yujiro Yamanaka, Satoko Hashimoto, Satoru Masubuchi, Akiyo Kameyama, Shin-ya Nishide, Sato Honma, Ken-ichi Honma
    International Symposium on Photic Bioimaging Satellite Symposium of Worldsleep 2011 on Human Circadian Clock- the 50th anniversary of temporal isolation study, 21 Oct. 2011, English, Poster presentation
    [International presentation]
  • Effect of scheduled physical exercise on re-entrainment of human circadian rhythms to an 8 h advanced sleep schedule in isolation facility　　　　　　　　　　　　　　　
    Yujiro Yamanaka, Satoko Hashimoto, Satoru Masubuchi, Akiyo Kameyama, Shin-ya Nishide, Sato Honma, Ken-ichi Honma
    WorldSleep 2011, 15 Oct. 2011, English, Public symposium
    [International presentation]
  • 明暗周期位相シフト時のマウス行動リズムを制御する視交叉上核内領域振動体の探索　　　　　　　　　　　　　　　
    山仲勇二郎, 本間さと, 本間研一
    第34回神経科学学会, 14 Sep. 2011, English, Poster presentation
    [Domestic Conference]
  • 明暗周期位相シフト後のマウス行動リズムと 視交叉上核領域内 mPeriod1 発現リズム　　　　　　　　　　　　　　　
    山仲勇二郎, 本間さと, 本間研一
    第91回北海道医学大会生理系分科会, 27 Aug. 2011, Japanese, Oral presentation
    [Domestic Conference]
  • The master and slave oscillators for behavioral rhythm in mice　　　　　　　　　　　　　　　
    Yujiro Yamanaka, Sato Honma, Ken-ichi Honma
    The III World Congress of Chronobiology, 09 May 2011, English, Nominated symposium
    [Invited], [International presentation]
  • 母子分離中の環境温度が新生ラットの概日リズムにおよぼす影響　　　　　　　　　　　　　　　
    吉川朋子, 松野亜美, 山仲勇二郎, 西出真也, 本間さと, 本間研一
    第17回日本時間生物学会学術大会, 20 Nov. 2010, Japanese, Poster presentation
    [Domestic Conference]
  • 時間隔離実験室を利用したヒト生物時計の構造解析. シンポジウム「体内時計制御工学を目指して」　　　　　　　　　　　　　　　
    山仲勇二郎
    第17回日本時間生物学会学術大会, 20 Nov. 2010, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • マウス末梢時計の8時間位相前進させた明暗周期への再同調は新奇環境暴露により促進される　　　　　　　　　　　　　　　
    山仲勇二郎, 本間さと, 本間研一
    第90回北海道医学大会生理系分科会・日本生理学会北海道地方会, 25 Sep. 2010, Japanese, Oral presentation
    [Domestic Conference]
  • 運動が生体リズムに与える影響. ワークショップ 生体リズムとスポーツパフォーマンス-基礎研究から現場へ　　　　　　　　　　　　　　　
    山仲勇二郎
    第65回日本体力医学会大会, 16 Sep. 2010, Japanese, Nominated symposium
    [Invited], [Domestic Conference]
  • 明暗周期位相シフト後の新奇環境暴露によるマウス末梢時計の再同調促進効果に関する考察　　　　　　　　　　　　　　　
    山仲勇二郎, 本間さと, 本間研一
    第87回生理学会大会, 21 May 2010, English, Oral presentation
    [Domestic Conference]
  • 脱同調パラダイム実験によるヒト生物時計の構造解析　　　　　　　　　　　　　　　
    山仲勇二郎, 橋本聡子, 中村宏次, 本間さと, 本間研一
    日本睡眠学会第34回定期学術集会, 26 Oct. 2009, Japanese, Oral presentation
    [Domestic Conference]
  • ヒト生体リズムの非光再同調に与える 身体運動の影響　　　　　　　　　　　　　　　
    山仲勇二郎, 橋本聡子, 西出真也, 棚橋祐典, 本間さと, 本間研一
    第15回日本時間生物学会学術大会, 08 Nov. 2008, Japanese, Oral presentation
    [Domestic Conference]
  • 低照度環境下における強制的睡眠覚醒スケジュール時の身体運動が深部体温リズムおよび睡眠脳波に与える影響　　　　　　　　　　　　　　　
    山仲勇二郎, 橋本聡子, 本間さと, 本間研一
    H20年度体温研究会, 19 Sep. 2008, Japanese, Oral presentation
    [Domestic Conference]
  • Differential effects of scheduled novel environment with a running-wheel on re-entrainment of circadian clocks in the suprachiasmatic nuclei and peripheral tissues in mice subjected to an 8 h shifted light-dark cycles: implications for jet lag　　　　　　　　　　　　　　　
    Yujiro Yamanaka, Sato Honma, Ken-ichi Honma
    第85回日本生理学会, 25 Mar. 2008, English, Poster presentation
    [Domestic Conference]
  • 8時間位相シフトさせた明暗周期に対するマウス行動リズムの再同調は新規環境暴露により促進される　　　　　　　　　　　　　　　
    山仲勇二郎, 本間さと, 本間研一
    第4回環境生理プレコングレス, 24 Mar. 2008, Japanese, Oral presentation
    [Domestic Conference]
  • Maturity process of cardiovascular autonomic function in resting supine position and response to postural change.　　　　　　　　　　　　　　　
    Yujiro Yamanaka, Koichi Honma
    5th Congress of the International Society for Autonomic Neuroscience: ISAN 2007, 05 Oct. 2007, English, Poster presentation
    [International presentation]
  • 脱同調パラダイムによるヒト生物時計の構造解析　　　　　　　　　　　　　　　
    山仲勇二郎
    第3回体温調節温度受容研究会, 27 Sep. 2007, Japanese, Oral presentation
    [Domestic Conference]
  • Four day physical exercise accelerates entrainment of human sleep-wake cycle but not of plasma melatonin rhythms to shifted sleep schedule under dim light condition.　　　　　　　　　　　　　　　
    Yujiro Yamanaka, Satoko Hashimoto, Yusuke Tanahashi, Shin-ya Nishide, Sato Honma, Ken-ichi Honma
    World Federation of Sleep Research and Sleep Medicine Society. 2007, 02 Sep. 2007, English, Poster presentation
    [International presentation]
  • Photic and non-photic entrainment of circadian behavioral rhythms in histamine decarboxylase knock out mice　　　　　　　　　　　　　　　
    Yujiro Yamanaka, Hiroshi Abe, Hiroshi Ohtsu, Sato Honma, Ken-ichi Honma
    第84回日本生理学会, 20 Mar. 2007, English, Oral presentation
    [Domestic Conference]
  • 4日間の身体運動によるヒト生物時計の位相反応曲線の作成　　　　　　　　　　　　　　　
    山仲勇二郎, 橋本聡子, 高須奈々, 西出真也, 棚橋祐典, 本間さと, 本間研一
    第3回環境生理プレコングレス, 19 Mar. 2007, Japanese, Oral presentation
    [Domestic Conference]
  • 体温リズムの生物時計による内因性支配と非光同調因子による外因性修飾作用　　　　　　　　　　　　　　　
    山仲勇二郎, 橋本聡子, 高須奈々, 本間さと, 本間研一
    第2回体温調節温度受容研究会, 11 Jan. 2007, Japanese, Oral presentation
    [Domestic Conference]
  • 低照度環境下での身体運動が睡眠脳波、心臓自律神経活動に及ぼす影響　　　　　　　　　　　　　　　
    山仲勇二郎, 橋本聡子, 高須奈々, 本間さと, 本間研一
    日本睡眠学会第31回定期学術集会, 29 Jun. 2006, Poster presentation
    [Domestic Conference]
  • Non-photic entrainment to scheduled 3-h wheel running in the mouse circadian rhythm　　　　　　　　　　　　　　　
    Yujiro Yamanaka, Hiroshi Abe, Sato Honma, Ken-ichi Honma
    第83回日本生理学会, 28 Mar. 2006, Oral presentation
    [Domestic Conference]
  • 身体運動に対するヒト生物時計の位相反応性～位相反応曲線におけるCross over pointの同定～　　　　　　　　　　　　　　　
    山仲勇二郎, 橋本聡子, 高須奈々, 宮崎俊彦, 本間さと, 本間研一
    第2回環境生理学プレコングレス, 27 Mar. 2006, Oral presentation
    [Domestic Conference]
  • Effects of exercise for circadian rhythm　　　　　　　　　　　　　　　
    Yujiro Yamanaka, Ken-ichi Honma, Toshihiko Miyazaki, Satoko Hashimoto, Sato Honma
    World Federation of Sleep Research and Sleep Medicine Society 2005, 22 Sep. 2005, English, Nominated symposium
    [Invited], [International presentation]
  • 生体リズムと体温　　　　　　　　　　　　　　　
    山仲勇二郎, 高須奈々, 橋本聡子, 本間研一
    体温調節温度受容研究会, Sep. 2005, Oral presentation
    [Domestic Conference]
  • 体位変化に対する心血管系自律神経機能の加齢現象～起立時超早期脈拍変動による検討，新たな健常値の提言～　　　　　　　　　　　　　　　
    山仲勇二郎, 本間甲一
    第57回日本自律神経学会総会, 29 Oct. 2004, Oral presentation
    [Domestic Conference]

Courses

  • Health and Society: Advanced lecture for Health and Sports Science　　　　　　　　　　　　　　　
    Hokkaido University
    Apr. 2017 - Present
  • 健康教育学特論：時間生物学　　　　　　　　　　　　　　　
    北海道大学大学院教育学研究院
    Apr. 2016 - Present
  • 生活健康学　　　　　　　　　　　　　　　
    北海道大学教育学部
    Apr. 2016 - Present
  • 教育衛生学　　　　　　　　　　　　　　　
    北海道大学教育学部
    Apr. 2016 - Present
  • 小児学校保健　　　　　　　　　　　　　　　
    北海道大学教育学部
    Apr. 2016 - Present
  • 体育学B　　　　　　　　　　　　　　　
    北海道大学
    Apr. 2016 - Present
  • 体育学A　　　　　　　　　　　　　　　
    北海道大学
    Apr. 2016 - Present
  • 生理学　　　　　　　　　　　　　　　
    北海道大学医学部医学科
    Apr. 2009 - Mar. 2017
  • 生理学実習　　　　　　　　　　　　　　　
    北海道大学医学部医学科
    Apr. 2009 - Mar. 2016

Affiliated academic society

  • Apr. 2008 - Present
    Society for Research on Biological Rhythms　　　　　　　　　　　　　　　
  • Apr. 2004 - Present
    日本生理学会　　　　　　　　　　　　　　　
  • Apr. 2004 - Present
    日本睡眠学会　　　　　　　　　　　　　　　
  • Apr. 2004 - Present
    日本時間生物学会　　　　　　　　　　　　　　　

Research Themes

  • Basic circadian rhythm research for establishing of the novel exercise program
    Grants-in-Aid for Scientific Research
    01 Apr. 2024 - 31 Mar. 2029
    山仲 勇二郎
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 24K02808
  • 在宅寝たきり療養者と家族介護者の概日リズムの実態解明と支援の構築
    科学研究費助成事業
    01 Apr. 2023 - 31 Mar. 2027
    久保田 直子, 山仲 勇二郎
    日本学術振興会, 基盤研究(C), 北海道科学大学, 23K10347
  • Understanding of sleep-wake regulatory mechanisms in nature
    Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    27 Oct. 2020 - 31 Mar. 2024
    小野 大輔, 池上 啓介, 山仲 勇二郎
    睡眠・覚醒や体温調節など、ほぼすべての生理機能には２４時間を１サイクルとする“概日リズム”が存在し、“概日時計”がその時間的調節を担う。我々の身体を構成する すべての細胞に、概日時計は備わり、時計遺伝子の転写・翻訳を介したフィードバックループがその中心的役割を示す。概日時計の中でも、中枢時計である「視交叉上核」はペースメーカーとして機能し、睡眠・覚醒のリズムを調節する。


    近年の光遺伝学の技術開発により、様々な生命現象を調節する神経回路が同定されてきている。哺乳類の睡眠研究においても、実験室の飼育環境下における睡眠・覚醒調節に関わる神経細胞が同定されてきた。一方、自然界における動物の睡眠研究はほとんどなされていない。しかし、最近になって自然界における睡眠・覚醒パターンが、実験室の結果とは大きく異なる事が示唆されてきた。国際生物学賞を受賞したDr. S. Daan（故）は、自然条件下（野外）でマウスを飼育すると、夜行性から昼行性にシフトする事を発見した。本研究では、自然環境下における動物行動の調節を担う神経メカニズムの解明を行う。
    Japan Society for the Promotion of Science, Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)), Nagoya University, 20KK0177
  • Mechanism of exercise effect on the central circadian pacemaker
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    01 Apr. 2019 - 31 Mar. 2024
    山仲 勇二郎
    本研究では雄性のC57BL/6-Tg(Period1-luc)マウスを用いて、マウスの自発活動リズムが①LD12:12明暗サイクルに同調、②恒常暗下でフリーラン、③恒常暗下で1日3時間の回転輪のついた新しいケージに移す新奇環境暴露スケジュールに同調、の3条件下で視交叉上核、弓状核、肝臓、骨格筋を採取し、生物発光測定装置を用いてPer1-lucリズムを測定した。各組織における培養翌日のPer1-lucリズムのピーク位相をリズム指標として、行動リズムの活動開始・終了位相および中枢・末梢時計間の位相関係を解析した。その結果、明暗サイクル同調時と新奇環境暴露スケジュール同調時におけるSCNのPer1-lucリズムのピーク位相はいずれも主観的明期(マウスの休息期)にみられた。肝臓および骨格筋のピーク位相は、主観的暗期(マウスの活動期)にみられた。行動リズム位相とSCN、肝臓、骨格筋のPer1-lucリズムの位相関係は明暗サイクル下と新規環境暴露スケジュール同調時で有意な差は認められなかった。一方、弓状核のPer1-lucリズム、明暗サイクル下および恒常暗でのフリーラン条件下では主観的暗期にピーク位相がみられたが、新奇環境暴露同調時に明暗サイクルおよび恒常暗条件に比べ、有意に位相前進し主観的明期にピーク位相がみられた。本研究により、恒常暗下での習慣的な運動スケジュールがマウスSCNの同調因子として作用し、明暗サイクル同調時におけるSCNと行動リズム、肝臓、骨格筋の末梢時計間の位相関係を維持した状態で同調することを明らかにした。
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 19H03993
  • 光と運動による生物時計調節メカニズムの解明：運動による効果的な生体リズム調整法の開発を目指して　　　　　　　　　　　　　　　
    Apr. 2020 - Mar. 2021
    山仲勇二郎
    公益財団法人 ヤマハ発動機スポーツ振興財団, 第14期生(2020年度)スポーツチャレンジ研究助成(基本), 北海道大学, Principal investigator
  • 就寝前の低強度短時間運動が睡眠・メンタルヘルスに及ぼす影響　　　　　　　　　　　　　　　
    公益財団法人明治安田厚生事業団若手研究者のための健康科学研究助成第35回助成金〈一般〉
    Oct. 2018 - Feb. 2020
    山仲勇二郎
    公益財団法人明治安田厚生事業団, Principal investigator, Competitive research funding
  • 糖代謝能の概日リズムと咀嚼運動に注目した新たな栄養食事指導法の提言
    公益財団法人秋山生命科学振興財団－2018年度研究助成〈一般〉－
    Jul. 2018 - Mar. 2019
    山仲勇二郎
    公益財団法人秋山生命科学振興財団, Principal investigator, Competitive research funding
  • からだにやさしいライフスタイル選択サポートの創造－生物時計同調と快適睡眠で高める女子学生のＱＯＬ－　　　　　　　　　　　　　　　
    センター・オブ・イノベーションプログラム COI若手連携研究ファンド 平成30年度連携研究
    Apr. 2018 - Mar. 2019
    山仲勇二郎
    国立研究開発法人科学技術振興機構, Principal investigator, Competitive research funding
  • 光と運動による生体リズムの調節メカニズム
    科学研究費補助金(基盤研究Ｃ)
    Apr. 2016 - Mar. 2019
    山仲勇二郎
    文部科学省, Principal investigator, Competitive research funding
  • 高照度光下での運動が生物時計の光反応性に与える影響　　　　　　　　　　　　　　　
    平成28年度睡眠健康推進機構学術研究助成
    Oct. 2016 - Mar. 2018
    山仲勇二郎
    睡眠健康推進機構, Principal investigator, Competitive research funding
  • 運動時の照明条件が睡眠・生体リズムに与える影響　　　　　　　　　　　　　　　
    第25回一般社団法人照明学会研究・教育助成 (奨励研究)
    Jul. 2016 - Mar. 2017
    山仲勇二郎
    一般社団法人照明学会, Principal investigator, Competitive research funding
  • 脳ペプチドダイアリシス法を応用した生物時計からの液性出力因子による概日リズム調節メカニズムの解明　　　　　　　　　　　　　　　
    平成27年度 公益信託 成茂神経科学研究助成基金
    Jul. 2015 - Mar. 2016
    山仲勇二郎
    公益信託 成茂神経科学研究助成基金, Principal investigator, Competitive research funding
  • Novel peptide-dialysis system to assess the effect of physical exercise on the circadian clock
    Grants-in-Aid for Scientific Research
    2013 - 2015
    Yamanaka Yujiro
    Brain microdialysis is a powerful technique for measuring a neurotransmitter in extracellular fluid from free moving animals. By using this technique with some modification for measuring a large molecule (neuropeptide), we examined circadian rhythm of neuropeptide released from a central circadian pacemaker of suprachiasmatic nucleus in free moving mice. The mice were placed under a normal light-dark cycle and constant darkness conditions for 2-4 days. During this period, artificial cerebrospinal fluid was perfused at a flow rate of 1 μl/min and the dialysate were collected every 1 h. As a result, circadian rhythm of AVP in dialysate was detected in some mice that the dialysis probe was inserted close to the SCN. The highest value was observed in early subjective day (ZT4). However, in other mice, circadian rhythms of AVP in dialysate were not detected. Technical improvement would be needed in future studies.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Principal investigator, Competitive research funding, 25350808
  • 食事時刻がヒトの生体リズムおよびエネルギー代謝調節に与える影響　　　　　　　　　　　　　　　
    公益財団法人 石本記念デサントスポーツ科学振興財団 第36回研究助成
    Jun. 2014 - Nov. 2014
    山仲勇二郎
    公益財団法人 石本記念デサントスポーツ科学振興財団, Principal investigator, Competitive research funding
  • Food entrainable circadian rhythm in humans
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    01 Apr. 2011 - 31 Mar. 2014
    HONMA Ken-ichi, NISHIDE Shin-ya, YAMANAKA Yujiro, HASHIMOTO Satoko
    Appearance of premeal anticipatory hormone peak and entrainability of restricted meal schedule were examined in humans who stayed in a temporal isolation facility without knowing the time of day. Meal was supplied once a day for 10 days. As a result, the premeal peak was not detected in plasma melatonin, cortisol, insulin, ghrelin, and leptin. On the other hand, the sleep-wake cycle was entrained by the meal schedule, whereas the circadian melatonin rhythm was not entrained showing phase-delay shifts. These findings indicated that the so-called food entrainable circadian rhythm failed to appear in humans under the present conditions, and that the meal schedule was the time cue for the sleep-wake cycle but not for the circadian pacemaker.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 23390047
  • 食事制限がヒトの生体リズムおよびエネルギー代謝調節に与える影響　　　　　　　　　　　　　　　
    公益財団法人サッポロ生物科学振興財団 第1回研究助成
    Jun. 2012 - Apr. 2013
    山仲勇二郎
    公益財団法人サッポロ生物科学振興財団, Principal investigator, Competitive research funding
  • 身体運動による生体リズム調節法の開発
    科学研究費補助金(若手研究(B))
    2011 - 2012
    山仲 勇二郎
    (研究の目的)本研究は、ヒト生物時計に対する高照度光と身体運動の相互作用を時間隔離実験室を使用し、行動（睡眠覚醒）、ホルモン（メラトニン）、深部体温のリズムを測定し検証する。(実施計画)本研究は、健康な20代の成人男性を対象に時間隔離実験室を使用して行う。被験者は、時間隔離実験室内で12泊13日生活する。実験は、通常のリズム位相を測定するベースライン期間(3日)、通常の睡眠時間帯を8時間位相前進する強制スケジュール期間(4日)、そして、睡眠時間や食事のタイミングを制限しないフリーラン期間(6日)、3つのセッションからなる。ベースラインおよび強制スケジュール期間中は8時間睡眠、16時間覚醒とし、覚醒時の実験室内の照度は約3000ルクスの高照度光とし、睡眠中は約0ルクスである。メラトニンリズムを計測するための採血時およびフリーラン期間中は約10ルクスの低照度に設定する。(研究実績)平成23年度の研究計画に従い、3回の隔離実験を行い、対照群4名、運動群4名より以下の結果を得た。[睡眠覚醒リズム]対照群（4名中3名）、運動群（4名）ともにフリーラン第1日目の睡眠開始位相は8時間前進した就寝時刻付近にみられ睡眠覚醒リズムは身体運動を負荷しなくとも高照度光のみで再同調が完了していた。[メラトニリズム]対照群、運動群ともに8時間前進スケジュール最終日ではベースライン期間から5～6時間の位相前進が認められた。メラトニンリズムの位相前進量は、対照群と運動群間では同程度であり、運動によるメラトニンリズムの再同調促進効果は認められなかった。
    文部科学省, 若手研究(B), 北海道大学, Principal investigator, Competitive research funding, 23700770
  • Synchronization effects of physical exercise on human peripheral clocks regulating behavior rhythms
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    2009 - 2011
    HASHIMOTO Satoko, TANAHASHI Yuhsuke, YAMANAKA Yujiro
    To clarify whether physical exercise is a time cue for the human circadian clock and the mechanism by which physical exercise entrains the clock, we performed a series of experiment under temporal isolation using an 8h phase-advanced desynchrony protocol. Adult female subjects were required to perfome physical exercise of 2 hour duration twice a day using bicycle ergometer. The circadian rhythms in plasma melatonin and deep body temperature, which are believed to be regulated by the central circadian pacemaker, were measured simultaneously with the sleep-wake cycle which is thought to be driven by the peripheral clock. As a result, the re-entrainment of the sleep-wake cycle to a 8 h phase-advanced schedule was accelerated by timed physical exercise under dim light of ca. 10 lx, whereas the plasma melatonin did not phase-advance regardless of timed physical exercise. On the other hand, the re-entrainment of the sleep-wake cycle was accomplished regardless of timed physical exercise under bright light of ca. 5,000 lx, whereas the plasma melatonin rhythm phase-advanced but did not fully entrain but phase-advanced with or without timed physical exercise. The findings indicate that time physical exercise has a potency to entrain the sleep-wake cycle, but the effect is masked under bright light conditions.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 21590249
  • Acceleration mechanism of re-entrainment of circadian rhythms by physical exercise in mammals
    Grants-in-Aid for Scientific Research(若手研究(B))
    2009 - 2010
    yujiro YAMANAKA
    The aim of present study was to clarify acceleration mechanism of re-entrainment of circadian behavioral and clock gene expression rhythm in peripheral tissues (peripheral clocks) to a large shift of light-dark cycle (e.g. jet-lag travel in humans) by physical exercise in mammals. We could demonstrate that the effect of physical exercise, such as exposure to new cage with a running-wheel, on the re-entrainment of peripheral clock was dependent on the timing of exposure. During the transient days in behavior after shift of light cycle, circadian clock gene expression rhythm in the central clock in the suprachiasmatic nucleus (SCN) showed a regional difference in the waveforms and phases. These finding addresses a new hypothesis that the scheduled physical exercise directly affect on the regional oscillator in the SCN. If so, it leads to increase a coupling strength between the SCN and peripheral clock and to accelerate re-entrainment of peripheral clocks by physical exercise.
    Ministry of Education, Culture, Sports, Science and Technology, 若手研究(B), 北海道大学, Principal investigator, Competitive research funding, 21700650
  • Analysis of multi-oscillator structure of biological clock
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
    2008 - 2010
    HONMA Ken-Ichi, TANAHASHI Yuhsuke, NISHIDE Shinya, NAKAMUEA Tomoko, YAMADA Yoshiko, YASUDA Tsubura, SHUDO Miwako, YAMANAKA Yuhjiro, HASHIMOTO Satoko, TOKUMARU Nobuko
    Oscillating neurons in the suprachiasmatic nucleus (SCN), the center of biological clock, constructs more than one regional pacemakers of different characteristics through mutual synchronization. The roles of regional pacemakers depend on the area of SCN, and their interaction determines the length of activity period, showing seasonal changes in behavioral rhythms. The function of biological clock is disrupted by restricted daily feeding or methamphetamine treatment, which is supposed to be due to desynchronization between the central and peripheral clocks. The peripheral clock(s) regulating behavioral rhythms is suggested to reside in the midbrain.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Hokkaido University, 20249010

Industrial Property Rights

  • 光照射装置
    Patent right, 田森 雄介, 山口 悦範, 山仲 勇二郎, 電制コムテック株式会社, 国立大学法人北海道大学
    特願2021-098449, 14 Jun. 2021
    特開2023-011076, 24 Jan. 2023
    202303020171919238
  • 光照射装置
    Patent right, 田森 雄介, 山口 悦範, 山仲 勇二郎, 電制コムテック株式会社, 国立大学法人北海道大学
    特願2021-098449, 14 Jun. 2021
    特許第7198460号, 21 Dec. 2022
    202303003030232482
  • 光照射装置　　　　　　　　　　　　　　　
    Patent right
    特願2021-098449, 14 Jun. 2021
    特許7198460, 21 Dec. 2022

Media Coverage

  • 生物時計から見た健康的な食習慣　　　　　　　　　　　　　　　
    Jan. 2021
    Myself
    キューピー株式会社
    キューピーニュース
    キューピーニュース. 561, 2021.1.28, [Pr]
  • 正しい睡眠で免疫力アップ　　　　　　　　　　　　　　　
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    北海道文化放送UHB
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    [Media report]
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    [Media report]
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    29 Nov. 2019
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  • Your body may not cope with evening stress: Study　　　　　　　　　　　　　　　
    28 Nov. 2019
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    28 Nov. 2019
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    [Internet]
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    27 Nov. 2019
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    [Internet]
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  • Beware of Evening Stress　　　　　　　　　　　　　　　
    27 Nov. 2019
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    [Internet]
  • 朝食かむほど血糖値低下 白米１０回→４０回で最大１４％ 北大など研究　　　　　　　　　　　　　　　
    27 Nov. 2019
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    [Paper]
  • 朝方の咀嚼運動の強化で、食後の血糖値が速やかに低下－北大ほか　　　　　　　　　　　　　　　
    26 Nov. 2019
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    医療NEWS QLifePro
    [Internet]
  • 【スポーツの力】未来をつくる＜４＞光と運動 快眠の解』
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    読売新聞
    10724110, [Paper]
  • あなたの睡眠、間違いかも！眠りの常識ウソ・ホント　　　　　　　　　　　　　　　
    02 Sep. 2019
    STV
    どさんこワイド179
    [Media report]
  • The Health Risks of Evening Stress　　　　　　　　　　　　　　　
    26 Jul. 2019
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    [Internet]
  • Stressresistent am Abend　　　　　　　　　　　　　　　
    05 Feb. 2019
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    [Internet]
  • How to plan your day to get the best out of your brain　　　　　　　　　　　　　　　
    01 Feb. 2019
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    [Internet]
  • Beware of stressful events in the evening　　　　　　　　　　　　　　　
    24 Dec. 2018
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    [Internet]
  • Beware of Stressful Events in the Evening　　　　　　　　　　　　　　　
    17 Dec. 2018
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    [Internet]
  • Stress in the evening harder on body than at other times: study　　　　　　　　　　　　　　　
    15 Dec. 2018
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    [Internet]
  • Beware of Stressful Events in the Evening　　　　　　　　　　　　　　　
    14 Dec. 2018
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    [Internet]
  • Beware of Stressful Events in the Evening　　　　　　　　　　　　　　　
    14 Dec. 2018
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    [Internet]
  • 「ストレス反応」は朝と夜で異なる 体内時計をストレスマネジメントに応用　　　　　　　　　　　　　　　
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    [Internet]
  • 夜はリラックスタイムではない！？ストレス防御機能が低下 北大がホルモン変化確認　　　　　　　　　　　　　　　
    05 Dec. 2018
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    [Paper]
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    03 Dec. 2018
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    [Internet]
  • Beware getting too stressed in the evening　　　　　　　　　　　　　　　
    02 Dec. 2018
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    [Internet]
  • ストレスからの防御は夜は弱い　　　　　　　　　　　　　　　
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    NHK 北海道のニュース
    [Media report]
  • Feeling Stressed At Night Takes A Big Toll On Your Body, Study Shows, So Here's How To Relax　　　　　　　　　　　　　　　
    30 Nov. 2018
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    [Internet]
  • We May Be More Vulnerable to Stress in the Evening　　　　　　　　　　　　　　　
    29 Nov. 2018
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  • 北海道大学、ストレス反応が朝と夜で異なる仕組みを解明～現代社会におけるストレスマネジメントへの応用に期待～　　　　　　　　　　　　　　　
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  • Beware of Evening Stress　　　　　　　　　　　　　　　
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  • Night Stress Is Different From Morning Stress, A New Study Shows, But Here’s The Best Way To Handle It　　　　　　　　　　　　　　　
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  • Your body may not cope with evening stress: Study　　　　　　　　　　　　　　　
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  • Evening Stress: Good or Bad?　　　　　　　　　　　　　　　
    27 Nov. 2018
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  • Study suggests possible vulnerability to evening stress　　　　　　　　　　　　　　　
    27 Nov. 2018
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    [Internet]
  • Beware of evening stress　　　　　　　　　　　　　　　
    26 Nov. 2018
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    [Internet]
  • Beware of evening stress　　　　　　　　　　　　　　　
    26 Nov. 2018
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    [Internet]
  • 医食同源 必須栄養素自ら判断　　　　　　　　　　　　　　　
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    [Paper]
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    19 Sep. 2017
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    [Media report]
  • 光と運動で時差ぼけ解消
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  • 北大、「明るい光＋運動」が時差ボケ解消に有効であることを明らかに
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