BLS-GAN: A Deep Layer Separation Framework for Eliminating Bone Overlap in Conventional Radiographs.
Haolin Wang, Yafei Ou, Prasoon Ambalathankandy, Gen Ota, Pengyu Dai, Masayuki Ikebe, Kenji Suzuki 0001, Tamotsu Kamishima
AAAI, 7674, 7681, 2025年
研究論文（国際会議プロシーディングス）

Natural Recovery of Very Limited Elbow Flexion After Rare Lateral Humeral Condylar Fracture in a 4-Year-Old Boy: A Case Report.
Koki Ohta, Yuichiro Matsui, Hiroyuki Kato, Daisuke Kawamura, Takeshi Endo, Daisuke Momma, Tamotsu Kamishima, Tatsunori Horie, Hirofumi Miyaji, Norimasa Iwasaki
JBJS case connector, 14, 4, 2024年10月01日, ［国際誌］
英語, 研究論文（学術雑誌）, CASE: A 4-year-old boy developed malunion after open reduction and internal fixation (ORIF) of a rare lateral condylar humeral fracture running from the lateral humerus, through the trochlear cartilage, to the medial trochlea. Five months after ORIF, the active elbow flexion was limited to 50°. Magnetic resonance imaging (MRI) showed a step-off of the anterior trochlear cartilage, causing the limited flexion. After conservative observation for 5 years, the flexion improved to 135° and MRI showed that the step-off had disappeared. CONCLUSION: This case indicates that it is possible for pediatric patients to recover their range of motion following malunion of an elbow fracture.

Artificial Intelligence Quantification of Enhanced Synovium Throughout the Entire Hand in Rheumatoid Arthritis on Dynamic Contrast-Enhanced MRI.
Yijun Mao, Kiko Imahori, Wanxuan Fang, Hiroyuki Sugimori, Shinji Kiuch, Kenneth Sutherland, Tamotsu Kamishima
Journal of magnetic resonance imaging : JMRI, 2024年05月28日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Challenges persist in achieving automatic and efficient inflammation quantification using dynamic contrast-enhanced (DCE) MRI in rheumatoid arthritis (RA) patients. PURPOSE: To investigate an automatic artificial intelligence (AI) approach and an optimized dynamic MRI protocol for quantifying disease activity in RA in whole hands while excluding arterial pixels. STUDY TYPE: Retrospective. SUBJECTS: Twelve RA patients underwent DCE-MRI with 27 phases for creating the AI model and tested on images with a variable number of phases from 35 RA patients. FIELD STRENGTH/SEQUENCE: 3.0 T/DCE T1-weighted gradient echo sequence (mDixon, water image). ASSESSMENT: The model was trained with various DCE-MRI time-intensity number of phases. Evaluations were conducted for similarity between AI segmentation and manual outlining in 51 ROIs with synovitis. The relationship between synovial volume via AI segmentation with rheumatoid arthritis magnetic resonance imaging scoring (RAMRIS) across whole hands was then evaluated. The reference standard was determined by an experienced musculoskeletal radiologist. STATISTICAL TEST: Area under the curve (AUC) of receiver operating characteristic (ROC), Dice and Spearman's rank correlation coefficients, and interclass correlation coefficient (ICC). A P-value <0.05 was considered statistically significant. RESULTS: A minimum of 15 phases (acquisition time at least 2.5 minutes) was found to be necessary. AUC ranged from 0.941 ± 0.009 to 0.965 ± 0.009. The Dice score was 0.557-0.615. Spearman's correlation coefficients between the AI model and ground truth were 0.884-0.927 and 0.736-0.831, for joint ROIs and whole hands, respectively. The Spearman's correlation coefficient for the additional test set between the model trained with 15 phases and RAMRIS was 0.768. CONCLUSION: The AI-based classification model effectively identified synovitis pixels while excluding arteries. The optimal performance was achieved with at least 15 phases, providing a quantitative assessment of inflammatory activity in RA while minimizing acquisition time. EVIDENCE LEVEL: 3 TECHNICAL EFFICACY: Stage 2.

Fully automatic quantification for hand synovitis in rheumatoid arthritis using pixel-classification-based segmentation network in DCE-MRI.
Wanxuan Fang, Yijun Mao, Haolin Wang, Hiroyuki Sugimori, Shinji Kiuch, Kenneth Sutherland, Tamotsu Kamishima
Japanese journal of radiology, 2024年05月24日, ［国内誌］
英語, 研究論文（学術雑誌）, PURPOSE: A classification-based segmentation method is proposed to quantify synovium in rheumatoid arthritis (RA) patients using a deep learning (DL) method based on time-intensity curve (TIC) analysis in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). MATERIALS AND METHODS: This retrospective study analyzed a hand MR dataset of 28 RA patients (six males, mean age 53.7 years). A researcher, under expert guidance, used in-house software to delineate regions of interest (ROIs) for hand muscles, bones, and synovitis, generating a dataset with 27,255 pixels with corresponding TICs (muscle: 11,413, bone: 8502, synovitis: 7340). One experienced musculoskeletal radiologist performed ground truth segmentation of enhanced pannus in the joint bounding box on the 10th DCE phase, or around 5 min after contrast injection. Data preprocessing included median filtering for noise reduction, phase-only correlation algorithm for motion correction, and contrast-limited adaptive histogram equalization for improved image contrast and noise suppression. TIC intensity values were normalized using zero-mean normalization. A DL model with dilated causal convolution and SELU activation function was developed for enhanced pannus segmentation, tested using leave-one-out cross-validation. RESULTS: 407 joint bounding boxes were manually segmented, with 129 synovitis masks. On the pixel-based level, the DL model achieved sensitivity of 85%, specificity of 98%, accuracy of 99% and precision of 84% for enhanced pannus segmentation, with a mean Dice score of 0.73. The false-positive rate for predicting cases without synovitis was 0.8%. DL-measured enhanced pannus volume strongly correlated with ground truth at both pixel-based (r = 0.87, p < 0.001) and patient-based levels (r = 0.84, p < 0.001). Bland-Altman analysis showed the mean difference for hand joints at the pixel-based and patient-based levels were -9.46 mm3 and -50.87 mm3, respectively. CONCLUSION: Our DL-based DCE-MRI TIC shape analysis has the potential for automatic segmentation and quantification of enhanced synovium in the hands of RA patients.

A deep registration method for accurate quantification of joint space narrowing progression in rheumatoid arthritis.
Haolin Wang, Yafei Ou, Wanxuan Fang, Prasoon Ambalathankandy, Naoto Goto, Gen Ota, Taichi Okino, Jun Fukae, Kenneth Sutherland, Masayuki Ikebe, Tamotsu Kamishima
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society, 108, 102273, 102273, 2023年09月, ［国際誌］
英語, 研究論文（学術雑誌）, Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that leads to progressive articular destruction and severe disability. Joint space narrowing (JSN) has been regarded as an important indicator for RA progression and has received significant attention. Radiology plays a crucial role in the diagnosis and monitoring of RA through the assessment of joint space. A new framework for monitoring joint space by quantifying joint space narrowing (JSN) progression through image registration in radiographic images has emerged as a promising research direction. This framework offers the advantage of high accuracy; however, challenges still exist in reducing mismatches and improving reliability. In this work, we utilize a deep intra-subject rigid registration network to automatically quantify JSN progression in the early stages of RA. In our experiments, the mean-square error of the Euclidean distance between the moving and fixed images was 0.0031, the standard deviation was 0.0661 mm and the mismatching rate was 0.48%. Our method achieves sub-pixel level accuracy, surpassing manual measurements significantly. The proposed method is robust to noise, rotation and scaling of joints. Moreover, it provides misalignment visualization, which can assist radiologists and rheumatologists in assessing the reliability of quantification, exhibiting potential for future clinical applications. As a result, we are optimistic that our proposed method will make a significant contribution to the automatic quantification of JSN progression in RA. Code is available at https://github.com/pokeblow/Deep-Registration-QJSN-Finger.git.

A deep registration method for accurate quantification of joint space narrowing progression in rheumatoid arthritis
Haolin Wang, Yafei Ou, Wanxuan Fang, Prasoon Ambalathankandy, Naoto Goto, Gen Ota, Taichi Okino, Jun Fukae, Kenneth Sutherland, Masayuki Ikebe, Tamotsu Kamishima
Computerized Medical Imaging and Graphics, 108, 102273, 102273, Elsevier BV, 2023年09月
研究論文（学術雑誌）

Fully automatic software for detecting radiographic joint space narrowing progression in rheumatoid arthritis: phantom study and comparison with visual assessment
Taichi Okino, Yafei Ou, Masayuki Ikebe, Kenichi Tamura, Kenneth Sutherland, Jun Fukae, Kazuhide Tanimura, Tamotsu Kamishima
JAPANESE JOURNAL OF RADIOLOGY, 41, 5, 510, 520, 2023年05月
英語, 研究論文（学術雑誌）

Fully automatic software for detecting radiographic joint space narrowing progression in rheumatoid arthritis: phantom study and comparison with visual assessment.
Taichi Okino, Yafei Ou, Masayuki Ikebe, Kenichi Tamura, Kenneth Sutherland, Jun Fukae, Kazuhide Tanimura, Tamotsu Kamishima
Japanese journal of radiology, 41, 5, 510, 520, 2023年05月, ［国内誌］
英語, 研究論文（学術雑誌）, PURPOSE: We have developed an in-house software equipped with partial image phase-only correlation (PIPOC) which can automatically quantify radiographic joint space narrowing (JSN) progression. The purpose of this study was to evaluate the software in phantom and clinical assessments. MATERIALS AND METHODS: In the phantom assessment, the software's performance on radiographic images was compared to the joint space width (JSW) difference using a micrometer as ground truth. A phantom simulating a finger joint was scanned underwater. In the clinical assessment, 15 RA patients were included. The software measured the radiological progression of the finger joints between baseline and the 52nd week. The cases were also evaluated with the Genant-modified Sharp score (GSS), a conventional visual scoring method. We also quantitatively assessed these joints' synovial vascularity (SV) on power Doppler ultrasonography (0, 8, 20 and 52 weeks). RESULTS: In the phantom assessment, the PIPOC software could detect changes in JSN with a smallest detectable difference of 0.044 mm at 0.1 mm intervals. In the clinical assessment, the JSW change of the joints with GSS progression detected by the software was significantly greater than those without GSS progression (p = 0.004). The JSW change of joints with positive SV at baseline was significantly higher than those with negative SV (p = 0.024). CONCLUSION: Our in-house software equipped with PIPOC can automatically and quantitatively detect slight radiographic changes of JSW in clinically inactive RA patients.

高齢者に対する生物学的製剤 csDMARDs効果不十分な高齢と若年の関節リウマチ患者におけるアバタセプト一年間投与の有効性と安全性の比較検討　　　　　　　　　　　　　　　
山田 善登, 村岡 成, 川添 麻衣, 廣瀬 恒, 河野 肇, 保田 晋助, 神島 保, 南木 敏宏
日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 688, 688, (一社)日本リウマチ学会, 2023年03月
日本語

Automatic Quantification of Enhancing Pannus of the Rheumatoid Hand using Machine Learning in DCE-MRI(タイトル和訳中)　　　　　　　　　　　　　　　
Fang Wanxuan, Mao Yijun, An Yujie, Sugimori Hiroyuki, Kiuch Shinji, Kamishima Tamotsu
日本医学放射線学会学術集会抄録集, 82回, S194, S194, (公社)日本医学放射線学会, 2023年03月
英語

Rheumatoid Arthritis Synovitis Segmentation Based on Unsupervised Learning and Time-intensity Curve Signal Data on Dynamic Contrast Enhaced MRI(タイトル和訳中)　　　　　　　　　　　　　　　
Mao Yijun, Fang Wanxuan, An Yujie, Sugimori Hiroyuki, Kiuch Shinji, Kamishima Tamotsu
日本放射線技術学会総会学術大会予稿集, 79回, 322, 322, (公社)日本放射線技術学会, 2023年03月
英語

A Sub-Pixel Accurate Quantification of Joint Space Narrowing Progression in Rheumatoid Arthritis
Yafei Ou, Prasoon Ambalathankandy, Ryunosuke Furuya, Seiya Kawada, Tianyu Zeng, Yujie An, Tamotsu Kamishima, Kenichi Tamura, Masayuki Ikebe
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, 27, 1, 53, 64, 2023年01月
英語, 研究論文（学術雑誌）

A Sub-Pixel Accurate Quantification of Joint Space Narrowing Progression in Rheumatoid Arthritis
Ou, Yafei, Ambalathankandy, Prasoon, Furuya, Ryunosuke, Kawada, Seiya, Zeng, Tianyu, An, Yujie, Kamishima, Tamotsu, Tamura, Kenichi, Ikebe, Masayuki
IEEE Journal of Biomedical and Health Informatics, 27, 1, 53, 64, 2023年01月
英語, 研究論文（学術雑誌）, Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects peripheral synovial joints, like fingers, wrists and feet. Radiology plays a critical role in the diagnosis and monitoring of RA. Limited by the current spatial resolution of radiographic imaging, joint space narrowing (JSN) progression of RA for the same reason above can be less than one pixel per year with universal spatial resolution. Insensitive monitoring of JSN can hinder the radiologist/rheumatologist from making a proper and timely clinical judgment. In this paper, we propose a novel and sensitive method that we call partial image phase-only correlation which aims to automatically quantify JSN progression in the early RA. The majority of the current literature utilizes the mean error, root-mean-square deviation and standard deviation to report the accuracy at pixel level. Our work measures JSN progression between a baseline and its follow-up finger joint images by using the phase spectrum in the frequency domain. Using this study, the mean error can be reduced to 0.0130 mm when applied to phantom radiographs with ground truth, and 0.0519 mm standard deviation for clinical radiography. With the sub-pixel accuracy far beyond usual manual measurements, we are optimistic that the proposed work is a promising scheme for automatically quantifying JSN progression.

A Sub-Pixel Accurate Quantification of Joint Space Narrowing Progression in Rheumatoid Arthritis.
Yafei Ou, Prasoon Ambalathankandy, Ryunosuke Furuya, Seiya Kawada, Tianyu Zeng, Yujie An, Tamotsu Kamishima, Kenichi Tamura, Masayuki Ikebe
IEEE journal of biomedical and health informatics, 27, 1, 53, 64, 2023年01月, ［国際誌］
英語, 研究論文（学術雑誌）, Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects peripheral synovial joints, like fingers, wrists and feet. Radiology plays a critical role in the diagnosis and monitoring of RA. Limited by the current spatial resolution of radiographic imaging, joint space narrowing (JSN) progression of RA for the same reason above can be less than one pixel per year with universal spatial resolution. Insensitive monitoring of JSN can hinder the radiologist/rheumatologist from making a proper and timely clinical judgment. In this paper, we propose a novel and sensitive method that we call partial image phase-only correlation which aims to automatically quantify JSN progression in the early RA. The majority of the current literature utilizes the mean error, root-mean-square deviation and standard deviation to report the accuracy at pixel level. Our work measures JSN progression between a baseline and its follow-up finger joint images by using the phase spectrum in the frequency domain. Using this study, the mean error can be reduced to 0.0130 mm when applied to phantom radiographs with ground truth, and 0.0519 mm standard deviation for clinical radiography. With the sub-pixel accuracy far beyond usual manual measurements, we are optimistic that the proposed work is a promising scheme for automatically quantifying JSN progression.

関節リウマチ患者の滑膜炎を自動で抽出するソフトウエアの開発 手のダイナミックMRIを用いた検討(Toward Development of Software Application that can Automatically Demonstrate the Distribution of Pannus in Rheumatoid Hand using Dynamic MRI Dataset)　　　　　　　　　　　　　　　
Fang Wanxuan, An Yujie, Sugimori Hiroyuki, Kiuchi Shinji, Kamishima Tamotsu
日本医学放射線学会学術集会抄録集, 81回, S210, S210, (公社)日本医学放射線学会, 2022年03月
英語

Feasibility of an Ultrasound-Based Method for Measuring Talar Displacement during the Anterior Drawer Stress Test Using a Telos Device: A Preliminary Study.
Kaori Tsutsumi, Utayo Nakaya, Yuta Koshino, Mari Tateno, Kazuhisa Matsumoto, Mai Tanaka, Mika Yokoyama, Tatsunori Horie, Mina Samukawa, Tamotsu Kamishima, Harukazu Tohyama
International journal of environmental research and public health, 19, 4, 2022年02月18日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, This study was conducted to measured talar displacement using ultrasound during an anterior drawer test (ADT) with a Telos device. Five adults (3 men and 2 women; 8 ankles; mean age: 23.2 y) with a history of ankle sprain and eight adults (5 men and 3 women; 16 ankles; mean age: 22.1 y) without a history of ankle sprain were recruited into a history of ankle sprain (HAS) and a control group, respectively. Talar displacement was observed in response to load forces applied by a Telos device during the ultrasound stress imaging test. The ultrasound probe was placed 5 mm inside from the center of the Achilles tendon on the posterior ankle along the direction of the major axis. The inter-rater reliability for the present method was classified as good and excellent (ICC(2,2) = 0.858 and 0.957 at 120 N and 150 N, respectively) in the control group and excellent (ICC(2,2) = 0.940 and 0.905 at 120 N and 150 N, respectively) in the HAS group, according to specific intraclass correlation coefficient values. We found that talar displacement during the ADT was lower in the HAS group than in the control group. Analysis of the receiver operating characteristic curve revealed that the quantitative ultrasound-based ADT using a Telos device was superior to the X-ray-based test in detecting reduced ankle joint mobility during the ADT (area under the curve of 0.905 and 0.726 at a force of 150 N using ultrasound-based and X-ray-based tests, respectively). Further investigation is needed; nevertheless, this preliminary study suggests that the ultrasound-based quantitative ADT using a Telos device might detect talar displacement more sensitively than the conventional stress X-ray.

Joint space narrowing progression quantification with joint angle correction in rheumatoid arthritis
Yafei Ou, Prasoon Ambalathankandy, Ryunosuke Furuya, Seiya Kawada, Tamotsu Kamishima, Masayuki Ikebe
2022 14TH BIOMEDICAL ENGINEERING INTERNATIONAL CONFERENCE (BMEICON 2022), 2022年
英語, 研究論文（国際会議プロシーディングス）

Social and physical effects of a pedometer and communication application among older men: a mixed-methods, pre/post pilot study
Hiroki Abe, Tamotsu Kamishima, Ryoji Ojima, Ryuta Onishi, Michiyo Hirano
Information, Communication & Society, 1, 20, Informa UK Limited, 2021年07月14日
研究論文（学術雑誌）

Giant intraosseous cyst-like lesions of the metacarpal bones in rheumatoid arthritis
Wanxuan Fang, Ikuma Nakagawa, Kenneth Sutherland, Kazuhide Tanimura, Tamotsu Kamishima
Journal of Imaging, 7, 7, MDPI AG, 2021年07月01日
英語, 研究論文（学術雑誌）

肝臓のMR弾性造影に関する半自動化定量ソフトウエアの結果の妥当性と再現性に関する研究(Validation and Reproducibility Study on Semi-automatic Quantification Software for MR Elastography of the Liver)　　　　　　　　　　　　　　　
Katsuumi Yuri, Kamishima Tamotsu, Sugimori Hiroyuki, Shimamura Tsuyoshi, Kawamura Norio, Takeda Hiroshi
日本放射線技術学会総会学術大会予稿集, 77回, 248, 249, (公社)日本放射線技術学会, 2021年03月
英語

Quantification of Joint Space Width Difference on Radiography Via Phase-Only Correlation (POC) Analysis: a Phantom Study Comparing with Various Tomographical Modalities Using Conventional Margin-Contouring.
Aimi Taguchi, Shun Shishido, Yafei Ou, Masayuki Ikebe, Tianyu Zeng, Wanxuan Fang, Koichi Murakami, Toshikazu Ueda, Nobutoshi Yasojima, Keitaro Sato, Kenichi Tamura, Kenneth Sutherland, Nozomi Oki, Ko Chiba, Kazuyuki Minowa, Masataka Uetani, Tamotsu Kamishima
Journal of digital imaging, 34, 1, 96, 104, 2020年12月02日, ［国際誌］
英語, 研究論文（学術雑誌）, Several visual scoring methods are currently used to assess progression of rheumatoid arthritis (RA) on radiography. However, they are limited by its subjectivity and insufficient sensitivity. We have developed an original measurement system which uses a technique called phase-only correlation (POC). The purpose of this study is to validate the system by using a phantom simulating the joint of RA patients.A micrometer measurement apparatus that can adjust arbitrary joint space width (JSW) in a phantom joint was developed to define true JSW. The phantom was scanned with radiography, 320 multi detector CT (MDCT), high-resolution peripheral quantitative CT (HR-pQCT), cone beam CT (CBCT), and tomosynthesis. The width was adjusted to the average size of a women's metacarpophalangeal joint, from 1.2 to 2.2 mm with increments of 0.1 mm and 0.01 mm. Radiographical images were analyzed by the POC-based system and manual method, and images from various tomographical modalities were measured via the automatic margin detection method. Correlation coefficients between true JSW difference and measured JSW difference were all strong at 0.1 mm intervals with radiography (POC-based system and manual method), CBCT, 320MDCT, HR-pQCT, and tomosynthesis. At 0.01 mm intervals, radiography (POC-based system), 320MDCT, and HR-pQCT had strong correlations, while radiography (manual method) and CBCT had low correlations, and tomosynthesis had no statistically significant correlation. The smallest detectable changes for radiography (POC-based system), radiography (manual method), 320MDCT, HR-pQCT, CBCT, and tomosynthesis were 0.020 mm, 0.041 mm, 0.076 mm, 0.077 mm, 0.057 mm, and 0.087 mm, respectively. We conclude that radiography analyzed with the POC-based system might sensitively detect minute joint space changes of the finger joint.

A preliminary study of an ultrasound-based method for measuring talar displacement during the anterior drawer stress test using a Telos device
Tsutsumi K, Nakaya U, Koshino Y, Tateno M, Matsumoto K, Tanaka M, Yokoyama M, Horie T, Samukawa M, Kamishima T, Tohyama H
2020年12月
研究論文（学術雑誌）

Validation of Fully Automatic Quantitative Software for Finger Joint Space Narrowing Progression for Rheumatoid Arthritis Patients.
Chiaki Narisawa, Kenneth Sutherland, Yutong Lu, Akira Furusaki, Akira Sagawa, Tamotsu Kamishima
Journal of digital imaging, 33, 6, 1387, 1392, 2020年12月, ［国際誌］
英語, 研究論文（学術雑誌）, In rheumatoid arthritis (RA), the radiographic progression of joint space narrowing (JSN) is evaluated using visual assessments. However, those methods are complicated and time-consuming. We developed an automatic system that can detect joint locations and compute the joint space difference index (JSDI), which was defined as the chronological change in JSN between two radiographs. The purpose of this study was to establish the validity of the software that automatically evaluates the temporal change of JSN. This study consisted of 39 patients with RA. All patients were treated with tocilizumab and underwent hand radiography (left and right hand separately) at 0, 6, and 12 months. The JSN was evaluated using mTSS (modified Total Sharp Score) by one musculoskeletal radiologist as well as our automatic system. Software measurement showed that JSDI between 0 and 12 months was significantly higher than that between 0 and 6 months (p < 0.01). While, there was no significant difference in mTSS between 0, 6, and 12 months. The group with higher disease activity at 0 months had significantly higher JSDI between 0 and 6 months than that with lower disease activity (p = 0.02). The automatic software can evaluate JSN progression of RA patients in the finger joint on X-ray.

Fibroma of tendon sheath of the hand in a 3-year-old boy: a case report.
Hiroki Shibayama, Yuichiro Matsui, Daisuke Kawamura, Atsushi Urita, Chikako Ishii, Tamotsu Kamishima, Mutsumi Nishida, Ai Shimizu, Norimasa Iwasaki
BMC musculoskeletal disorders, 21, 1, 732, 732, 2020年11月10日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Fibroma of tendon sheath (FTS) is a rare benign soft tissue tumor that often occurs in the upper extremities. It manifests as a slow-growing mass, often without tenderness or spontaneous pain. FTS occurs most commonly in people aged 20-40 years and is extremely rare in young children. Because FTS presents with atypical physical and imaging findings, it might be misdiagnosed as another soft tissue tumor such as a ganglion cyst or tenosynovial giant cell tumor (TSGCT). Although marginal resection is usually performed, a high rate of local recurrence is reported. CASE PRESENTATION: A boy aged 3 years and 1 month visited our outpatient clinic with a complaint of a mass of the left hand. An elastic hard mass approximately 20 mm in diameter could be palpated on the volar side of his left little finger. This mass was initially diagnosed as a ganglion cyst at another hospital. Ultrasonography revealed a well-circumscribed hypoechoic mass with internal heterogeneity on the flexor tendon. On magnetic resonance imaging (MRI), the mass showed iso signal intensity to muscle on T1-weighted images, and homogeneously low signal intensity to muscle on T2-weighted images. The mass was peripherally enhanced after contrast administration. FTS was initially suspected as the diagnosis on the basis of these imaging features. Because of the limited range of motion of his little finger, surgery was performed when he was 4 years old. Histopathological findings indicated the mass was well-circumscribed and contained scattered spindle cells embedded in a prominent collagenous matrix. The spindle cells contained elongated and cytologically bland nuclei with a fine chromatin pattern. Nuclear pleomorphism and multinucleated giant cells were not observed. On the basis of these findings, we made a diagnosis of FTS. One year after surgery, no signs of local recurrence were observed. CONCLUSIONS: We experienced an extremely rare case of FTS in the hand of a 3-year-old child. We especially recommend ultrasonography for hand tumors of young children to diagnose or eliminate ganglion cysts. MRI helped differentially diagnose FTS from TSGCT. Although marginal resection can be performed as a treatment, great care should be taken postoperatively because FTS has a high possibility of local recurrence.

Processes that enable public health professionals to organize preventive care support groups.
Miki Oichi, Tamotsu Kamishima, Michiyo Hirano
Public health nursing (Boston, Mass.), 37, 6, 880, 888, 2020年11月, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVES: This study examines the structure of the process that public health professionals (PHPs) use to organize preventive care groups for older adults and the elements that strengthen this process. DESIGN AND SAMPLE: The study was conducted using a quantitative descriptive design. Anonymous self-administered questionnaires were distributed by mail to 919 PHPs, including nurses and social workers employed by local governments in a Japanese prefecture, who facilitated recreational groups for older adults for the purposes of preventive care. Measures Items related to the process and the awareness of support were based on previous research. The process structure was examined using exploratory factor analysis, while multiple logistic regression analysis was used to study strengthening elements. RESULTS: The process yielded six factors (encouraging clarity with respect to the group's activity policy; creating connections with other resources; fostering independence; encouraging activity evaluation; creating relationships with group members; understanding the strengths and weaknesses of communities and individuals) with a total of 23 items. Two of three indicators of awareness of support were significantly related to the process. CONCLUSIONS: Understanding the importance of strengthening elements might improve support groups for older adults.

Fully automatic quantitative software for assessment of minute finger joint space narrowing progression on radiographs: evaluation in rheumatoid arthritis patients with long-term sustained clinical low disease activity.
Kazuki Kato, Kenneth Sutherland, Yuki Tanaka, Masaru Kato, Jun Fukae, Kazuhide Tanimura, Tamotsu Kamishima
Japanese journal of radiology, 38, 10, 979, 986, 2020年10月, ［国内誌］
英語, 研究論文（学術雑誌）, PURPOSE: Rheumatoid arthritis (RA) causes joint space narrowing (JSN) as a form of joint destruction. We developed an automatic system that can detect joint locations and compute the joint space difference index (JSDI), which was defined as the chronological change in JSN between two radiographs. This study aims to evaluate the application of "machine vision" for radiographic image of the finger joints. MATERIALS AND METHODS: Fifteen RA patients with long-term sustained clinical low disease activity were recruited. All patients underwent hand radiography and power Doppler ultrasonography (PDUS). The JSN was evaluated using the Genant-modified Sharp scoring (GSS) method and the automatic system. Synovial vascularity (SV) was assessed quantitatively using ultrasonography. RESULTS: There were no significant differences in the JSDI between the joints with JSN and those without JSN on GSS (p = 0.052). The JSDI of the joints with SV was significantly higher than those without SV (p = 0.043). The JSDI of the no therapeutic response group was significantly higher than those of the response group (p < 0.001). CONCLUSION: Our software can automatically evaluate temporal changes of JSN, which might free rheumatologists / radiologists from the burden of scoring hand radiography.

Non-tuberculosis Mycobacterium Tenosynovitis with Rice Bodies in a Patient with Systemic Lupus Erythematosus.
Yuichiro Fujieda, Keita Ninagawa, Yuichiro Matsui, Michihiro Kono, Tamotsu Kamishima, Norimasa Iwasaki, Tatsuya Atsumi
Internal medicine (Tokyo, Japan), 59, 18, 2317, 2320, 2020年09月15日, ［国内誌］
英語, 研究論文（学術雑誌）, Infectious disease with various presentations in systemic lupus erythematosus often resembles lupus flare. A 37-year-old woman presented with a swollen left index finger that had not resolved, despite 7 years of immunosuppressive treatment. MRI showed rice-body formation in the flexor tendon sheath and tenosynovectomy demonstrated chronic synovitis with epithelioid granuloma. A mycobacterial culture confirmed invasive mycobacterial tenosynovitis due to Mycobacterium chelonae. The patient was treated with moxifloxacin and clarithromycin and completely recovered.

Relationship between Upper Body Posture Angle and Vertebral Body Posture Angle in Lateral Flexion and Rotation Posture
Yoshio TSUCHIYA, Takayuki TANAKA, Tamotsu KAMISHIMA
Advanced Biomedical Engineering, 9, 181, 188, Japanese Society for Medical and Biological Engineering, 2020年09月, ［査読有り］
英語, 研究論文（大学，研究機関等紀要）, Lumbar loading causes increased intervertebral pressure and is an important factor in low back pain. However, it is difficult to quantitatively judge the actions that affect lumbar load and the magnitude of lumbar load increase. Low back pain occurs not only in the workplace but also during activities of daily living. Therefore, it is necessary to investigate the factors inducing low back pain by measuring movements in various planes and determining the magnitude of the lumbar load. Accordingly, the lumbar spine should be examined during various movements. Several studies have examined vertebral bodies in the anteflexion posture. However, the relationship between body flexion angle and vertebral body angle during lateral flexion and rotation remains unknown. In this study, we proposed an estimation method for changes in vertebral body angle during lateral flexion and rotation in the lumbosacral region using a wearable sensor system we previously developed. The accuracy of the proposed estimation method was evaluated and demonstrated using X-ray images.

Editorial for "Clinical Potential of UTE-MRI for Assessing the COVID-19: Patient- and Lesion-Based Comparative Analysis".
Tamotsu Kamishima, Yujie An, Wanxuan Fang, Yutong Lu
Journal of magnetic resonance imaging : JMRI, 52, 3, 956, 957, 2020年09月, ［国際誌］
英語

Fluvastatin prevents the development of arthritis in env-pX rats via up-regulation of Rho GTPase-activating protein 12.
Shun Tanimura, Mutsumi Nishida, Tatsunori Horie, Tamotsu Kamishima, Hitomi Matsumoto, Yutaka Morimura, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Tatsuya Atsumi, Akihiro Ishizu
Experimental and molecular pathology, 115, 104454, 104454, 2020年08月, ［国際誌］
英語, 研究論文（学術雑誌）, The pleiotropic effects of statins, including an antiarthritic potential, have been noted. This study aimed to determine the efficacy of statins on rheumatoid arthritis (RA) and clarify how statins affect its pathogenesis. Fluvastatin (500 μg/kg/day) or vehicle was given per os to env-pX rats, which carry the human T-cell leukemia virus type I env-pX gene and spontaneously develop destructive arthritis mimicking RA, for 30 days. Blood sampling and ultrasonography (US) of the ankle joints were conducted on days 0, 10, 20, and 30. On day 30, all rats were euthanized, and the ankle joints were subjected to histological analysis. To clarify how fluvastatin affects the pathogenesis of RA, comprehensive serum exosomal microRNA (miRNA) analysis was performed. Gene expression in the primary culture of synovial fibroblasts derived from arthritic rat and human and non-arthritic rat periarticular tissues was determined quantitatively by real-time reverse transcription-polymerase chain reaction (RT-PCR). As a result, the development of arthritis in env-pX rats was significantly suppressed by fluvastatin, which was evident from the viewpoints of serology, US imaging, and histology. Comprehensive serum exosomal miRNA analysis suggested that the expression of Rho GTPase-activating protein 12 (Arhgap12) was decreased in arthritic env-pX rats but increased with the administration of fluvastatin. Corresponding results were obtained by quantitative RT- PCR using primary culture of synovial fibroblasts. The collective findings suggest that fluvastatin prevents the development of arthritis in env-pX rats via the up-regulation of ARHGAP12. This study suggests that ARHGAP12 can be a possible therapeutic target of RA.

肝臓のMRエラストグラフィにおける閾値によるSemi-automatic Quantification Softwareの検証研究(Validation Study on Semi-automatic Quantification Software by Threshold Value for MR Elastography of the Liver)　　　　　　　　　　　　　　　
Katsuumi Yuri, Kamishima Tamotsu, Sugimori Hiroyuki, Shimamura Tsuyoshi, Kawamura Norio, Takeda Hiroshi
日本放射線技術学会総会学術大会予稿集, 76回, 318, 319, (公社)日本放射線技術学会, 2020年03月
英語

Quick and accurate selection of hand images among radiographs from various body parts using deep learning.
Kohei Fujiwara, Wanxuan Fang, Taichi Okino, Kenneth Sutherland, Akira Furusaki, Akira Sagawa, Tamotsu Kamishima
Journal of X-ray science and technology, 28, 6, 1199, 1206, 2020年, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Although rheumatoid arthritis (RA) causes destruction of articular cartilage, early treatment significantly improves symptoms and delays progression. It is important to detect subtle damage for an early diagnosis. Recent software programs are comparable with the conventional human scoring method regarding detectability of the radiographic progression of RA. Thus, automatic and accurate selection of relevant images (e.g. hand images) among radiographic images of various body parts is necessary for serial analysis on a large scale. OBJECTIVE: In this study we examined whether deep learning can select target images from a large number of stored images retrieved from a picture archiving and communication system (PACS) including miscellaneous body parts of patients. METHODS: We selected 1,047 X-ray images including various body parts and divided them into two groups: 841 images for training and 206 images for testing. The training images were augmented and used to train a convolutional neural network (CNN) consisting of 4 convolution layers, 2 pooling layers and 2 fully connected layers. After training, we created software to classify the test images and examined the accuracy. RESULTS: The image extraction accuracy was 0.952 and 0.979 for unilateral hand and both hands, respectively. In addition, all 206 test images were perfectly classified into unilateral hand, both hands, and the others. CONCLUSIONS: Deep learning showed promise to enable efficiently automatic selection of target X-ray images of RA patients.

Computed diffusion-weighted imaging for differentiating synovial proliferation from joint effusion in hand arthritis.
Yuki Tanaka, Motoshi Fujimori, Koichi Murakami, Hiroyuki Sugimori, Nozomi Oki, Takatoshi Aoki, Tamotsu Kamishima
Rheumatology international, 39, 12, 2111, 2118, 2019年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, The objective of this study is to investigate computed DWI (cDWI) as an alternative method to contrast-enhanced MRI in comparison with directory measured DWI (mDWI) and apparent diffusion coefficient (ADC) for differentiating synovial proliferation from joint effusion. Nine patients suspected with RA (5 women) were included in this study. A radiologist identified region of interest (ROI) based on STIR, and evaluated using a 5-point grading scale of 0 (fluid) to 4 (synovial proliferation) according to the degree of contrast enhancement within the ROI. cDWI was synthesized for b values from 1000 to 2000 at 200 s/mm2 intervals using the combination of b values at mDWI. In addition to ADC values, contrast ratios were calculated using signal intensity for each ROI on the mDWI and cDWI. Visual assessment by a radiologist was conducted between pairs of STIR image and mDWI or cDWI. ROI grades were most significantly correlated with cDWI2000 based on b values of 400-1000 s/mm2 (rs = 0.405, p < 0.01). The area under the curve of cDWI2000 based on b values of 400-1000 s/mm2 (0.762) was larger than that of ADC values (0.570-0.608) when comparing low versus high contrast enhancement grades. Both cDWI1800 (200-1000) and cDWI2000 (400-1000) demonstrated high sensitivity and specificity in visual assessment (84.6% and 66.7%, respectively). The cDWI2000 based on b values of 400-1000 s/mm2 may be useful for noninvasive differentiation of synovial proliferation from joint effusion in hand arthritis.

Intravoxel incoherent motion MRI for discrimination of synovial proliferation in the hand arthritis: A prospective proof-of-concept study.
Motoshi Fujimori, Koichi Murakami, Hiroyuki Sugimori, Yutong Lu, Kenneth Sutherland, Nozomi Oki, Takatoshi Aoki, Tamotsu Kamishima
Journal of magnetic resonance imaging : JMRI, 50, 4, 1199, 1206, 2019年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

肝臓のMR Elastography検査におけるスライス位置の検討　　　　　　　　　　　　　　　
勝海 友里, 神島 保, 杉森 博行, 嶋村 剛, 川村 典生, 武田 宏司
日本放射線技術学会雑誌, 75, 9, 1056, 1056, (公社)日本放射線技術学会, 2019年09月
日本語

Quantitative power Doppler signal assessment in the subchondral bone region of the metacarpophalangeal joint is an effective predictor of radiographic progression in the hand of rheumatoid arthritis: a pilot study.
Motoshi Fujimori, Tamotsu Kamishima, Akihiro Narita, Mihoko Henmi, Masaru Kato, Kenneth Sutherland, Mutsumi Nishida, Yuki Tanaka, Lu Yutong, Kazuhide Tanimura, Tatsuya Atsumi
Rheumatology international, 39, 8, 1413, 1421, 2019年08月, ［国際誌］
英語, 研究論文（学術雑誌）, Ultrasonography is useful for assessment of synovitis in the hand of rheumatoid arthritis (RA) patients. The aim of this study was to investigate the predictive value of the quantitative power Doppler (PD) signal assessment in the subchondral bone region of the metacarpophalangeal (MCP) joint in patients with RA showing radiographic progression of the hand by comparing with those of previously reported scoring systems. Twenty-two patients (20 women) with RA who underwent power Doppler ultrasonography (PDUS) of the bilateral one to five MCP joints at baseline were included in the study. Radiography of both hands was performed at baseline and at 1 year. PDUS of the synovial space was evaluated according to semi-quantitative scoring (0-3) and quantitative measurement (0-100%). The PD signal in the subchondral bone region was qualitatively (0, 1) and quantitatively (mm2) assessed. The performance of PDUS assessment was compared using the area under the curve (AUC) of the receiver operating characteristic (ROC) curve and the risk ratio (RR). As a predictor for radiographic progression, the quantitative PD signal assessment in the subchondral bone region (AUC = 0.842, p < 0.01) was equivalent to quantitative vascularity (AUC = 0.817, p < 0.05) and semi-quantitative scoring (AUC = 0.754, p < 0.05). As for the RR of the PD signal in the subchondral bone region for radiographic progression, the quantitative PD signal assessment was 5.40 (p < 0.01), whereas the qualitative PD signal assessment was 1.60 (p = 0.204). Quantitative PD signal assessment in the subchondral bone region can predict radiographic progression in the hand of RA patients.

Detection of Increased Vascular Signal in Arthritis-Prone Rats Without Joint Swelling Using Superb Microvascular Imaging Ultrasonography.
Tatsunori Horie, Mutsumi Nishida, Shun Tanimura, Tamotsu Kamishima, Erika Tamai, Yutaka Morimura, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Tatsuya Atsumi, Akihiro Ishizu
Ultrasound in medicine & biology, 45, 8, 2086, 2093, 2019年08月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, This study aimed to determine whether ultrasonography (US) can detect increased vascular signal in the synovial tissue before overt synovitis in rheumatoid arthritis (RA). Env-pX rats that spontaneously develop RA-like synovitis were used. Ankle joints of 15 pre-morbid env-pX rats were observed with power Doppler and superb microvascular imaging (SMI) using an ultrahigh-frequency (8-24 MHz) probe. Signal values were counted as the number of pixels. The total number of vessels and vessel area in the synovial tissue were histologically evaluated. Dilated vessels were determined from the mean value of synovial vessels in three wild-type rats. In all env-pX rats, apparent synovial proliferation was not observed. However, vasodilation was evident. Only SMI values were significantly correlated with the number of dilated vessels (r = 0.585, p = 0.022) but not with the total number of vessels. US with SMI using ultrahigh-frequency probe can detect increased vascular signal in the synovial tissue of arthritis-prone rats.

Detection of Fine Radiographic Progression in Finger Joint Space Narrowing Beyond Human Eyes: Phantom Experiment and Clinical Study with Rheumatoid Arthritis Patients.
Kazuki Kato, Nobutoshi Yasojima, Kenichi Tamura, Shota Ichikawa, Kenneth Sutherland, Masaru Kato, Jun Fukae, Kazuhide Tanimura, Yuki Tanaka, Taichi Okino, Yutong Lu, Tamotsu Kamishima
Scientific reports, 9, 1, 8526, 8526, 2019年06月12日, ［国際誌］
英語, 研究論文（学術雑誌）, The visual assessment of joint space narrowing (JSN) on radiographs of rheumatoid arthritis (RA) patients such as the Genant-modified Sharp score (GSS) is widely accepted but limited by its subjectivity and insufficient sensitivity. We developed a software application which can assess JSN quantitatively using a temporal subtraction technique for radiographs, in which the chronological change in JSN between two radiographs was defined as the joint space difference index (JSDI). The aim of this study is to prove the superiority of the software in terms of detecting fine radiographic progression in finger JSN over human observers. A micrometer measurement apparatus that can adjust arbitrary joint space width (JSW) in a phantom joint was developed to define true JSW. We compared the smallest detectable changes in JSW between the JSDI and visual assessment using phantom images. In a clinical study, 222 finger joints without interval score change on GSS in 15 RA patients were examined. We compared the JSDI between joints with and without synovial vascularity (SV) on power Doppler ultrasonography during the follow-up period. True JSW difference was correlated with JSDI for JSW differences ranging from 0.10 to 1.00 mm at increments of 0.10 mm (R2 = 0.986 and P < 0.001). Rheumatologists were difficult to detect JSW difference of 0.30 mm or less. The JSDI of finger joints with SV was significantly higher than those without SV (P = 0.030). The software can detect fine differences in JSW that are visually unrecognizable.

軟骨下骨領域におけるパワードプラ血流信号の定量評価 関節破壊の予後予測
藤森 元嗣, 田中 悠貴, Lu Yutong, 勝海 友里, 中川 紗良, 神島 保, 成田 明宏, 邉見 美穂子, 谷村 一秀, 加藤 将, 渥美 達也, Sutherland Kenneth, 西田 睦
北海道医学雑誌, 94, 1, 58, 59, 北海道医学会, 2019年05月
日本語

関節リウマチにおける滑膜増殖評価:IVIM MRI
藤森元嗣, LU Yutong, 藤原滉平, 村上公一, 杉森博之, 神島保, SUTHERLAND Kenneth, 大木望, 青木隆敏
北海道医学雑誌, 94, 1, 57‐58, 58, 北海道医学会, 2019年05月, ［査読有り］
日本語, 研究論文（学術雑誌）

肝MRエラストグラフィーの半自動定量化ソフトウェアに関する検証研究(Validation Study on Semi-Automatic Quantification Software for MR Elastography of the Liver)　　　　　　　　　　　　　　　
Katsuumi Yuri, Kamishima Tamotsu, Sugimori Hiroyuki, Shimamura Tsuyoshi, Kawamura Norio, Takeda Hiroshi
日本放射線技術学会総会学術大会予稿集, 75回, 211, 212, (公社)日本放射線技術学会, 2019年03月
英語

Automatic Radiographic Quantification of Joint Space Narrowing Progression in Rheumatoid Arthritis Using POC.
Yafei Ou, Prasoon Ambalathankandy, Takeshi Shimada, Tamotsu Kamishima, Masayuki Ikebe
16th IEEE International Symposium on Biomedical Imaging(ISBI), 1183, 1187, IEEE, 2019年
研究論文（国際会議プロシーディングス）

幼児の手指に発生した腱鞘線維腫(Fibroma of the Tendon Sheath)の1例
石井 智佳子, 松井 雄一郎, 河村 太介, 瓜田 淳, 新井 隆太, 岩崎 倫政, 神島 保, 岩井 孝仁, 西田 睦, 清水 亜衣
北海道整形災害外科学会雑誌, 61, 137th suppl, 41, 41, 北海道整形災害外科学会, 2019年
日本語

全自動解析ソフトウェアによるリウマチ患者の関節裂隙狭小化進行評価
田中 悠貴, 近藤 麻菜, 市川 翔太, 神島 保, 高橋 英治, 古崎 章, 天崎 吉晴
北海道医学雑誌, 93, 2, 123, 123, 北海道医学会, 2018年11月
日本語

関節リウマチの関節破壊進行予測におけるパワードプラ超音波検査の定量的評価の有用性
瀬野 結実香, 勝海 友里, 藤森 元嗣, 堀江 達則, 西田 睦, 神島 保, 加藤 將, 保田 晋助, 渥美 達也
北海道医学雑誌, 93, 2, 123, 123, 北海道医学会, 2018年11月
日本語

Active synovitis in the presence of osteitis predicts residual synovitis in patients with rheumatoid arthritis with a clinical response to treatment.
Jun Fukae, Kazuhide Tanimura, Masato Isobe, Akemi Kitano, Mihoko Henmi, Maria Nakai, Yuko Aoki, Fumihiko Sakamoto, Akihiro Narita, Takeya Ito, Akio Mitsuzaki, Megumi Matsuhashi, Masato Shimizu, Tamotsu Kamishima, Tatsuya Atsumi, Takao Koike
International journal of rheumatic diseases, 21, 10, 1809, 1814, 2018年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, AIM: To clarify the relationship between active synovitis/osteitis and subsequent residual synovitis (R-synovitis) in patients with rheumatoid arthritis (RA). METHODS: Three hundred and twenty finger joints of 16 patients with active RA at baseline (Disease Activity Score with 28 joints - erythrocyte sedimentation rate > 3.2) who subsequently achieved clinical low disease activity or remission afterwards were analyzed. Synovial vascularity (SV) was assessed according to a semi-quantitative ultrasound score (grades 0-3). Active synovitis was defined by SV positivity at baseline. R-synovitis was defined by the presence of grade > 2 SV at the 24th week. Osteitis was detected by magnetic resonance imaging (MRI) at baseline as trabecular bone lesions with water content and indistinct margins. RESULTS: Ultrasonography detected active synovitis in 116 joints at baseline. Forty-seven joints had R-synovitis at the 24th week. MRI detected osteitis in 12 joints at baseline. The presence of active synovitis with osteitis at baseline was significantly correlated with R-synovitis at the 24th week. CONCLUSIONS: Active synovitis in the presence of osteitis predicted R-synovitis regardless of whether there was a clinical improvement in RA.

Autologous Osteochondral Mosaicplasty for Centrally and Laterally Located, Advanced Capitellar Osteochondritis Dissecans in Teenage Athletes: Clinical Outcomes, Radiography, and Magnetic Resonance Imaging Findings.
Tadanao Funakoshi, Daisuke Momma, Yuki Matsui, Tamotsu Kamishima, Yuichiro Matsui, Daisuke Kawamura, Yusuke Nagano, Norimasa Iwasaki
The American journal of sports medicine, 46, 8, 1943, 1951, 2018年07月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Autologous osteochondral mosaicplasty (ie, mosaicplasty) results in satisfactory clinical outcomes and reliable return to play for patients with large or unstable lesions due to osteochondritis dissecans (OCD) of the humeral capitellum. However, the association between the healing of the reconstructed cartilage and clinical outcomes remains unclear. PURPOSE: To evaluate the efficacy of mosaicplasty in teenage athletes through use of clinical scores and imaging. The secondary purpose was to compare the clinical outcomes with images of centrally and laterally located lesions. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: This study analyzed 22 elbows (all male patients; mean age, 13.5 ± 1.2 years) with capitellar OCD managed with mosaicplasty. Patients were divided into 2 groups according to the location of the lesions: central (10 patients) and lateral (12 patients). Evaluation was performed through use of the clinical rating system of Timmerman and Andrews, plain radiographs, and magnetic resonance imaging (MRI; the cartilage repair monitoring system of Roberts). The mean follow-up period was 27.5 months (range, 24-48 months). RESULTS: Lateral lesions were significantly larger than central lesions (147.1 ± 51.9 mm2 vs 95.5 ± 27.4 mm2, P = .01). No other significant differences were found between central and lateral lesions. Timmerman and Andrews scores for both central and lateral lesions improved significantly from 125.0 ± 30.1 points and 138.3 ± 34.5 points preoperatively to 193.5 ± 11.3 points and 186.7 ± 18.1 points, respectively, at final follow-up ( P < .0001, P < .0001). Radiography identified complete graft incorporation in all cases and the absence of severe osteoarthritic changes or displaced osteochondral fragments. In the lateral group, the radial head ratio at final follow-up (1.83 ± 0.23) was significantly larger than the preoperative findings (1.75 ± 0.14, P = .049). The quality of joint surface reconstruction was found to be acceptable for central and lateral lesions on MRI evaluation. CONCLUSION: Mosaicplasty resulted in satisfactory clinical outcomes and smooth cartilage surface integrity in teenage athletes with OCD on their return to competition-level sports activities irrespective of lesion location.

Composite assessment of power Doppler ultrasonography and MRI in rheumatoid arthritis: a pilot study of predictive value in radiographic progression after one year.
Motoshi Fujimori, Tamotsu Kamishima, Masaru Kato, Yumika Seno, Kenneth Sutherland, Hiroyuki Sugimori, Mutsumi Nishida, Tatsuya Atsumi
The British journal of radiology, 91, 1086, 20170748, 20170748, 2018年06月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Radiographic temporal subtraction analysis can detect finger joint space narrowing progression in rheumatoid arthritis with clinical low disease activity.
Taichi Okino, Tamotsu Kamishima, Kenneth Lee Sutherland, Jun Fukae, Akihiro Narita, Shota Ichikawa, Kazuhide Tanimura
Acta radiologica (Stockholm, Sweden : 1987), 59, 4, 460, 467, SAGE Publications Inc., 2018年04月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

超音波とMRIの複合的評価は生物学的疾患修飾性抗リウマチ薬(bDMARDs)を投与中の関節リウマチにおけるX線上の関節破壊の予測能を改善する(Composite Assessment of Ultrasonography and MRI Improves the Prognostic Power of Joint Destruction on Radiograph in Rheumatoid Arthritis on Biological Disease-modifying Antirheumatic Drugs(bDMARDs))　　　　　　　　　　　　　　　
Fujimori Motoshi, Kamishima Tamotsu, Seno Yumika, Sugimori Hiroyuki, Nishida Mutsumi, Atsumi Tatsuya
日本放射線技術学会総会学術大会予稿集, 74回, 231, 232, (公社)日本放射線技術学会, 2018年03月
英語

リウマチ性疾患の画像2:関節エコーその他 超高周波プローブを用いたSuperb Micro-vascular Imagingによる超音波検査でのラット足関節の早期関節炎診断　　　　　　　　　　　　　　　
西田 睦, 谷村 瞬, 神島 保, 西端 友香, 益田 紗季子, 中沢 大悟, 外丸 詩野, 渥美 達也, 石津 明洋
日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 485, 485, (一社)日本リウマチ学会, 2018年03月
日本語

スタチンの関節炎抑制効果とその機序の解明　　　　　　　　　　　　　　　
谷村 瞬, 西田 睦, 神島 保, 西端 友香, 益田 紗季子, 中沢 大悟, 外丸 詩野, 渥美 達也, 石津 明洋
日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 778, 778, (一社)日本リウマチ学会, 2018年03月
日本語

Quantification of hand synovitis in rheumatoid arthritis: Arterial mask subtraction reinforced with mutual information can improve accuracy of pixel-by-pixel time-intensity curve shape analysis in dynamic MRI.
Yuto Kobayashi, Tamotsu Kamishima, Hiroyuki Sugimori, Shota Ichikawa, Atsushi Noguchi, Michihito Kono, Toshitake Iiyama, Kenneth Sutherland, Tatsuya Atsumi
Journal of magnetic resonance imaging : JMRI, 48, 3, 687, 694, 2018年03月01日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Longitudinal CT study of sarcopenia due to hepatic failure after living donor liver transplantation.
Takahiro Onuma, Tamotsu Kamishima, Tsuyoshi Shimamura, Norio Kawamura, Kenichiro Yamashita, Kenneth Sutherland, Hiroshi Takeda
Quantitative imaging in medicine and surgery, 8, 1, 25, 31, AME Publishing Company, 2018年02月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Quantitative knee cartilage measurement at MR imaging of patients with anterior cruciate ligament tear.
Kazuki Kato, Tamotsu Kamishima, Eiji Kondo, Tomohiro Onodera, Shota Ichikawa
Radiological physics and technology, 10, 4, 431, 438, Springer Tokyo, 2017年12月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Effectiveness of whole-body magnetic resonance imaging for the efficacy of biologic anti-rheumatic drugs in patients with rheumatoid arthritis: A retrospective pilot study.
Michihito Kono, Tamotsu Kamishima, Shinsuke Yasuda, Keita Sakamoto, Sawako Abe, Atsushi Noguchi, Toshiyuki Watanabe, Yuka Shimizu, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Tatsuya Atsumi
Modern rheumatology, 27, 6, 953, 960, 2017年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Maintenance treatment using abatacept with dose reduction after achievement of low disease activity in patients with rheumatoid arthritis (MATADOR) - A prospective, multicenter, single arm pilot clinical trial.
Shinsuke Yasuda, Kazumasa Ohmura, Hiroshi Kanazawa, Takashi Kurita, Yujiro Kon, Tomonori Ishii, Yuichiro Fujieda, Satoshi Jodo, Kazuhide Tanimura, Michio Minami, Tomomasa Izumiyama, Takumi Matsumoto, Yoshiharu Amasaki, Yoko Suzuki, Hideki Kasahara, Naofumi Yamauchi, Masaru Kato, Tamotsu Kamishima, Akito Tsutsumi, Hiromitsu Takemori, Takao Koike, Tatsuya Atsumi
Modern rheumatology, 27, 6, 930, 937, 2017年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Power Doppler signal calibration in the finger joint between two models of ultrasound machine: a pilot study using a phantom and joints in patients with rheumatoid arthritis.
Ryosuke Sakano, Katsumi Saito, Tamotsu Kamishima, Mutsumi Nishida, Tatsunori Horie, Atsushi Noguchi, Michihito Kono, Kenneth Sutherland, Tatsuya Atsumi
Acta radiologica (Stockholm, Sweden : 1987), 58, 10, 1238, 1244, 2017年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Computer-Based Radiographic Quantification of Joint Space Narrowing Progression Using Sequential Hand Radiographs: Validation Study in Rheumatoid Arthritis Patients from Multiple Institutions.
Shota Ichikawa, Tamotsu Kamishima, Kenneth Sutherland, Jun Fukae, Kou Katayama, Yuko Aoki, Takanobu Okubo, Taichi Okino, Takahiko Kaneda, Satoshi Takagi, Kazuhide Tanimura
Journal of digital imaging, 30, 5, 648, 656, 2017年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

関節リウマチ患者の関節腔狭隘化を定量的に評価するためのcomputer-based temporal subtraction法(Quantitative Assessment of Joint Space Narrowing Progression in the Feet of Rheumatoid Arthritis Patients Using a Computer-based Temporal Subtraction Method)　　　　　　　　　　　　　　　
田中 悠貴, 千葉 拓貴, 神島 保, 市川 翔太, 沖野 太一, 深江 淳, 青木 悠子, 谷村 一秀
日本放射線技術学会雑誌, 73, 9, 832, 832, (公社)日本放射線技術学会, 2017年09月
英語

Superb micro-vascular imaging法のシグナル強度と関節内血管径の関係性 関節リウマチの実験動物モデル(Relationship between Superb Micro-vascular Imaging Signal Quantity and Vessel Diameter in the Joints: Experimental Animal Models of Rheumatoid Arthritis)　　　　　　　　　　　　　　　
玉井 絵里香, 神島 保, 森村 豊, 堀江 達則, 谷村 瞬, 西田 睦, 石津 明洋, 外丸 詩野
日本放射線技術学会雑誌, 73, 9, 855, 855, (公社)日本放射線技術学会, 2017年09月
英語

Cartilage quantification using contrast-enhanced MRI in the wrist of rheumatoid arthritis: cartilage loss is associated with bone marrow edema.
Motoshi Fujimori, Satoko Nakamura, Kiminori Hasegawa, Kunihiro Ikeno, Shota Ichikawa, Kenneth Sutherland, Tamotsu Kamishima
The British journal of radiology, 90, 1077, 20170167, 20170167, 2017年08月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Visceral adipose tissue area measurement at a single level: can it represent visceral adipose tissue volume?
Yusuke Noumura, Tamotsu Kamishima, Kenneth Sutherland, Hideho Nishimura
The British journal of radiology, 90, 1077, 20170253, 20170253, 2017年08月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Semi-Automated Quantification of Finger Joint Space Narrowing Using Tomosynthesis in Patients with Rheumatoid Arthritis.
Shota Ichikawa, Tamotsu Kamishima, Kenneth Sutherland, Hideki Kasahara, Yuka Shimizu, Motoshi Fujimori, Nobutoshi Yasojima, Yohei Ono, Takahiko Kaneda, Takao Koike
Journal of digital imaging, 30, 3, 369, 375, 2017年06月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Pre-operative volume rather than area of skeletal muscle is a better predictor for post-operative risks for respiratory complications in living-donor liver transplantation.
Yuki Wada, Tamotsu Kamishima, Tsuyoshi Shimamura, Norio Kawamura, Kenichiro Yamashita, Kenneth Sutherland, Hiroshi Takeda
The British journal of radiology, 90, 1072, 20160938, 20160938, 2017年04月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

関節リウマチにおける手の滑膜炎定量のためのダイナミック造影強調MRIを用いた簡易的なアプローチ 完全自動化した全画素の分析(Simplified Approach to Quantification for Hand Synovitis in Rheumatoid Arthritis Using Dynamic Contrast Enhanced MRI: Full-Automatic Pixel-By-Pixel Analysis)　　　　　　　　　　　　　　　
Kobayashi Yuto, Kamishima Tamotsu, Ichikawa Shota, Sugimori Hiroyuki, Noguchi Atsushi, Kono Michihito, Atsumi Tatsuya
日本放射線技術学会総会学術大会予稿集, 73回, 178, 179, (公社)日本放射線技術学会, 2017年03月
英語

関節リウマチの治療 用法・用量・スイッチ・無効・減量・中止 アバタセプト減量による関節リウマチ維持療法 北海道・東北地域での多施設前向き介入試験　　　　　　　　　　　　　　　
保田 晋助, 大村 一将, 金澤 洋, 栗田 崇史, 近 祐次郎, 石井 智徳, 藤枝 雄一郎, 浄土 智, 谷村 一秀, 三浪 三千男, 泉山 朋政, 松本 巧, 天崎 吉晴, 鈴木 陽子, 笠原 英樹, 山内 尚文, 加藤 将, 神島 保, 堤 明人, 竹森 弘光, 小池 隆夫, 渥美 達也
日本リウマチ学会総会・学術集会プログラム・抄録集, 61回, 565, 565, (一社)日本リウマチ学会, 2017年03月, ［査読有り］
日本語

A reliability study using computer-based analysis of finger joint space narrowing in rheumatoid arthritis patients.
Katsuya Hatano, Tamotsu Kamishima, Kenneth Sutherland, Masaru Kato, Ikuma Nakagawa, Shota Ichikawa, Keisuke Kawauchi, Shota Saitou, Masaya Mukai
Rheumatology international, 37, 2, 189, 195, 2017年02月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Pixel-by-Pixel Arterial Spin Labeling Blood Flow Pattern Variation Analysis for Discrimination of Rheumatoid Synovitis: A Pilot Study.
Taro Sakashita, Tamotsu Kamishima, Hiroyuki Sugimori, Minghui Tang, Atsushi Noguchi, Michihito Kono, Kenneth Sutherland, Tatsuya Atsumi
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 16, 1, 78, 83, 2017年01月10日, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Relationship between power Doppler grade and the pathological blood vessel features in long-standing rheumatoid arthritis.
Katsumi Saito, Asami Abe, Tamotsu Kamishima, Hajime Ishikawa, Kunihiko Wakaki, Akihiro Ishizu
Rheumatology international, 36, 12, 1689, 1690, 2016年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

One-year maintenance with routine assessment of patient index data 3-based remission may inhibit radiographic progression in patients with rheumatoid arthritis treated with routine clinical therapy: A retrospective comparison of radiographic outcome and its prognostic factors between maintained remissions with patient-reported outcome index and physician-oriented disease activity indices.
Kou Katayama, Takanobu Okubo, Toshikazu Sato, Kiyomi Kamiya, Richio Fukai, Satomi Abe, Hiroshi Ito, Yuichi Makino, Tamotsu Kamishima
Modern rheumatology, 26, 6, 817, 827, 2016年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Tomosynthesis can facilitate accurate measurement of joint space width under the condition of the oblique incidence of X-rays in patients with rheumatoid arthritis.
Yohei Ono, Rina Kashihara, Nobutoshi Yasojima, Hideki Kasahara, Yuka Shimizu, Kenichi Tamura, Kaori Tsutsumi, Kenneth Sutherland, Takao Koike, Tamotsu Kamishima
The British journal of radiology, 89, 1062, 20150967, 20150967, 2016年06月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Bizarre parosteal osteochondromatous proliferation (Nora's lesion) affecting the distal end of the ulna: a case report.
Yuichiro Matsui, Tadanao Funakoshi, Hideyuki Kobayashi, Tomoko Mitsuhashi, Tamotsu Kamishima, Norimasa Iwasaki
BMC musculoskeletal disorders, 17, 130, 130, 2016年03月16日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

読影医が求める画像技術－手のMRIについて
神島 保
医用画像情報学会雑誌, 33, 1, 4, 7, 医用画像情報学会, 2016年
日本語, Current magnetic resonance imaging （MRI） techniques and high‐quality coil system can provide exquisite anatomic detail of the wrist and fingers. They present a valuable tool for assessment and characterization of traumatic injuries to small structures, various arthropathies, and neoplastic processes. As imaging quality continues to improve, the clinical significance of MRI of this field becomes more apparent in the evaluation and management of these entities.

X線画像に基づく腰部負荷ウェアラブルセンサの提案と腰仙椎アライメント推定
土谷圭央, 日下聖, 田中孝之, 松尾祥和, 小田まこと, 笹木工, 神島保, 山中正紀
日本機械学会論文集(Web), 82, 843, ROMBUNNO.16‐00072(J‐STAGE), 00072-16-00072, 一般社団法人 日本機械学会, 2016年, ［査読有り］
日本語, <p>Anteflexion of the spine is essential for many physical activities of daily living. However, this motion places the lumbar disks because it generats heavy load due to changes in the shape of the lumbar spine and can lead to low back pain. In older to reduce low back pain, here we proposed a wearable sensor system configuration that can estimate lumbosacral alignment and lumbar load by measuring the shape of the lumbar skin when the lumbosacral alignment changes. The shape of the lumbar skin and posture angle are measured by using curvature sensors and accelerometers. In addition, the system must be constructed in consideration of the physique, in order to absorb in a variety of human. We proposed this system by measuring the body parameters of anteflexion and studied the change in dimensions of the lumbar spine from changes in posture. By extracting the dimensions of the lumbosacral spine in X-ray images, the attitude angle, body surface area and the dimensions of the lumbosacral spine have relevance. The lumbosacral dimensions calibration method was developed by using that relation. Lumbosacral alignment estimation considering the difference in physiques is developed, and lumbosacral spine alignment was to improve the estimation accuracy. The proposed method could improve accuracy lumbosacral alignment estimation.</p>

A Calibration Method for Interbody Distance in Lumbosacral Alignment Estimation.
Yoshio Tsuchiya, Takashi Kusaka, Takayuki Tanaka, Yoshikazu Matsuo, Makoto Oda, Tsukasa Sasaki, Tamotsu Kamishima, Masanori Yamanaka
Intelligent Robotics and Applications - 9th International Conference, ICIRA 2016, Tokyo, Japan, August 22-24, 2016, Proceedings, Part II, 200, 210, Springer, 2016年, ［査読有り］

Detection and measurement of rheumatoid bone and joint lesions of fingers by tomosynthesis: a phantom study for reconstruction filter setting optimization.
Yohei Ono, Tamotsu Kamishima, Nobutoshi Yasojima, Kenichi Tamura, Kaori Tsutsumi
Radiological physics and technology, 9, 1, 6, 14, Springer Tokyo, 2016年01月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Performance of computer-based analysis using temporal subtraction to assess joint space narrowing progression in rheumatoid patients.
Shota Ichikawa, Tamotsu Kamishima, Kenneth Sutherland, Takanobu Okubo, Kou Katayama
Rheumatology international, 36, 1, 101, 8, 2016年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Consensus-based identification of factors related to false-positives in ultrasound scanning of synovitis and tenosynovitis.
Kei Ikeda, Akihiro Narita, Michihiro Ogasawara, Shigeru Ohno, Yutaka Kawahito, Atsushi Kawakami, Hiromu Ito, Isao Matsushita, Takeshi Suzuki, Kenta Misaki, Takehisa Ogura, Tamotsu Kamishima, Yohei Seto, Ryuichi Nakahara, Atsushi Kaneko, Takayuki Nakamura, Mihoko Henmi, Jun Fukae, Keiichiro Nishida, Takayuki Sumida, Takao Koike
Modern rheumatology, 26, 1, 9, 14, 2016年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Radiographic quantifications of joint space narrowing progression by computer-based approach using temporal subtraction in rheumatoid wrist.
Shota Ichikawa, Tamotsu Kamishima, Kenneth Sutherland, Takanobu Okubo, Kou Katayama
The British journal of radiology, 89, 1057, 20150403, 20150403, 2016年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Accurate quantitative assessment of synovitis in rheumatoid arthritis using pixel-by-pixel, time-intensity curve shape analysis.
Taro Sakashita, Tamotsu Kamishima, Yuto Kobayashi, Hiroyuki Sugimori, Minghui Tang, Kenneth Sutherland, Atsushi Noguchi, Michihito Kono, Tatsuya Atsumi
The British journal of radiology, 89, 1061, 20151000, 20151000, 2016年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

リウマチ超音波検査機器に関するアンケート調査報告
齋藤 克己, 神島 保, 坂野 稜典, 堀江 達則, 西田 睦, 成田 明宏, 谷村 一秀, 小池 隆夫
北海道医学雑誌, 90, 2, 144, 144, 北海道医学会, 2015年11月
日本語

18F-FDG-PET/CT better localizes active spinal infection than MRI for successful minimally invasive surgery.
Masayuki Nakahara, Manabu Ito, Naoya Hattori, Keiichi Magota, Masahiko Takahata, Ken Nagahama, Hideki Sudo, Tamotsu Kamishima, Nagara Tamaki, Norimasa Iwasaki
Acta radiologica (Stockholm, Sweden : 1987), 56, 7, 829, 36, 2015年07月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Absolute reliability of adipose tissue volume measurement by computed tomography: application of low-dose scan and minimal detectable change--a phantom study.
Takahiro Onuma, Tamotsu Kamishima, Tsukasa Sasaki, Motomichi Sakata
Radiological physics and technology, 8, 2, 312, 9, Springer Tokyo, 2015年07月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

腱板付着部の血流よりみた腱板断裂の成因とその治癒過程　　　　　　　　　　　　　　　
船越 忠直, 西田 睦, 神島 保, 瓜田 淳, 末永 直樹, 岩崎 倫政
日本整形外科学会雑誌, 89, 2, S434, S434, (公社)日本整形外科学会, 2015年03月
日本語

リウマチ性滑膜炎の描出 従来型のコントラスト造影MRIに対する二重標識後待ち時間(PLD)測定を利用したASL画像分析法の利点(Depiction of Rheumatoid Synovitis: Advantage of ASL Imaging Analysis Using Dual Post Labeling Delay(PLD) Settings Over Conventional Contrast Enhanced MRI)　　　　　　　　　　　　　　　
Sakashita Taro, Kamishima Tamotsu, Sugimori Hiroyuki, Tou Meiki, Noguchi Atsushi, Kono Michihito, Atsumi Tatsuya
日本放射線技術学会総会学術大会予稿集, 71回, 185, 185, (公社)日本放射線技術学会, 2015年02月
英語

関節リウマチ診療におけるパワードプラ超音波検査の機種間差 PRF設定と滑膜血流描出能の関係　　　　　　　　　　　　　　　
坂野 稜典, 神島 保, 西田 睦, 堀江 達則
超音波医学, 42, 1, 94, 94, (公社)日本超音波医学会, 2015年01月
日本語

Bilateral breast MRI by use of dual-source parallel radiofrequency excitation and image-based shimming at 3 Tesla: improvement in homogeneity on fat-suppression imaging.
Kinya Ishizaka, Fumi Kato, Satoshi Terae, Suzuko Mito, Noriko Oyama-Manabe, Tamotsu Kamishima, Mitsuhiro Nakanishi, Hiroyuki Sugimori, Hiroyuki Hamaguchi, Hiroki Shirato
Radiological physics and technology, 8, 1, 4, 12, 2015年01月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）, In this study, we aimed to compare fat-suppression homogeneity on breast MR imaging by using dual-source parallel radiofrequency excitation and image-based shimming (DS-IBS) with single-source radiofrequency excitation with volume shim (SS-Vol) at 3 Tesla. Twenty patients were included. Axial three-dimensional T1-weighted turbo-field-echo breast images with DS-IBS and SS-Vol were obtained. Fat suppression was scored with four grade points. The contrast of the pectoral muscle and the fat in each breast area was obtained in the head medial, head lateral, foot medial, and foot lateral areas. The axillary space was calculated and compared between DS-IBS and SS-Vol. The average DS-IBS score was significantly higher than that of SS-Vol. The mean contrasts of fat in the foot lateral areas and axillary spaces on DS-IBS images were significantly higher than on SS-Vol images.

Power Doppler signal calibration between ultrasound machines by use of a capillary-flow phantom for pannus vascularity in rheumatoid finger joints: a basic study.
Ryosuke Sakano, Tamotsu Kamishima, Mutsumi Nishida, Tatsunori Horie
Radiological physics and technology, 8, 1, 120, 4, Springer-Verlag Tokyo, 2015年01月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Calibration method for lumbosacral dimensions in wearable sensor system of lumbar alignment.
Yoshio Tsuchiya, Takashi Kusaka, Takayuki Tanaka, Yoshikazu Matsuo, Makoto Oda, Tsukasa Sasaki, Tamotsu Kamishima, Masanori Yamanaka
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2015, 3909, 12, 2015年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Efficacy of Tocilizumab in Patients with Rheumatoid Arthritis: Sequential Evaluation Using Whole-Body Magnetic Resonance Imaging.
Michihito Kono, Shinsuke Yasuda, Kazumasa Ohmura, Tomoko Fukui, Sanae Shimamura, Ikuma Nakagawa, Atsushi Noguchi, Haruki Shida, Toshiyuki Watanabe, Yuka Shimizu, Takashi Kurita, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Keita Sakamoto, Tamotsu Kamishima, Tatsuya Atsumi
ARTHRITIS & RHEUMATOLOGY, 66, S518, S518, 2014年10月, ［査読有り］
英語

単純X線写真におけるリウマチ患者の関節裂隙狭小化の変化 経時差分技術を用いた検討　　　　　　　　　　　　　　　
佐々木 亮祐, 神島 保, 市川 翔太, Sutherland Kenneth, 大久保 学宣, 片山 耕
日本放射線技術学会雑誌, 70, 9, 1054, 1054, (公社)日本放射線技術学会, 2014年09月
日本語

単純X線写真に対する経時差分技術を用いたリウマチ患者の関節裂隙狭小化評価 手根部関節への応用　　　　　　　　　　　　　　　
市川 翔太, 神島 保, 佐々木 亮祐, Sutherland Kenneth, 大久保 学宣, 片山 耕
日本放射線技術学会雑誌, 70, 9, 1054, 1055, (公社)日本放射線技術学会, 2014年09月
日本語

手関節のリウマチ滑膜炎におけるPixel-by-Pixel TIC解析　　　　　　　　　　　　　　　
坂下 太郎, 神島 保, 杉森 博行, 唐 明輝, 河野 通仁, 渥美 達也
日本放射線技術学会雑誌, 70, 9, 965, 965, (公社)日本放射線技術学会, 2014年09月
日本語

Structural deterioration of finger joints with ultrasonographic synovitis in rheumatoid arthritis patients with clinical low disease activity.
Jun Fukae, Masato Isobe, Akemi Kitano, Mihoko Henmi, Fumihiko Sakamoto, Akihiro Narita, Takeya Ito, Akio Mitsuzaki, Masato Shimizu, Kazuhide Tanimura, Megumi Matsuhashi, Tamotsu Kamishima, Tatsuya Atsumi, Takao Koike
Rheumatology (Oxford, England), 53, 9, 1608, 12, 2014年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

毛細血管ファントムを用いた超音波装置機器間のパワードプラ信号校正 パンヌス血流評価結果の機種間差低減を目指して
坂野 稜典, 神島 保, 堀江 達則, 西田 睦
北海道医学雑誌, 89, 1, 94, 94, 北海道医学会, 2014年05月
日本語

多時相造影MRIのTIC解析を用いた滑膜炎抽出
小野 雅人, 神島 保, 杉森 博行, 唐 明輝, 河野 通仁, 渥美 達也
北海道医学雑誌, 89, 1, 93, 93, 北海道医学会, 2014年05月
日本語

Ultrasound assessment of synovial pathologic features in rheumatoid arthritis using comprehensive multiplane images of the second metacarpophalangeal joint: identification of the components that are reliable and influential on the global assessment of the whole joint.
Kei Ikeda, Yohei Seto, Akihiro Narita, Atsushi Kawakami, Yutaka Kawahito, Hiromu Ito, Isao Matsushita, Shigeru Ohno, Keiichiro Nishida, Takeshi Suzuki, Atsushi Kaneko, Michihiro Ogasawara, Jun Fukae, Mihoko Henmi, Takayuki Sumida, Tamotsu Kamishima, Takao Koike
Arthritis & rheumatology (Hoboken, N.J.), 66, 3, 523, 32, 2014年03月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Lingering fat signals with CHESS in simultaneous imaging of both hands can be improved with rice pads in both 1.5T and 3.0T.
Susumu Moriya, Yukio Miki, Tamotsu Kamishima, Tosiaki Miyati, Mitsunori Kanagaki, Yukako Matsuno, Tsuneo Yokobayashi
European journal of radiology, 82, 9, 1458, 62, 2013年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

CT osteoabsorptiometry法を用いた野球選手肘関節における応力分布解析
門間太輔, 岩崎倫政, 大泉直美, 中土裕樹, 船越忠直, 神島保, 但野茂, 三浪明男
北海道整形災害外科学会雑誌, 54, 2, 162, 166, 2013年03月, ［査読有り］
日本語, 研究論文（学術雑誌）

Positive synovial vascularity in patients with low disease activity indicates smouldering inflammation leading to joint damage in rheumatoid arthritis: time-integrated joint inflammation estimated by synovial vascularity in each finger joint.
Jun Fukae, Masato Isobe, Akemi Kitano, Mihoko Henmi, Fumihiko Sakamoto, Akihiro Narita, Takeya Ito, Akio Mitsuzaki, Masato Shimizu, Kazuhide Tanimura, Megumi Matsuhashi, Tamotsu Kamishima, Tatsuya Atsumi, Takao Koike
Rheumatology (Oxford, England), 52, 3, 523, 8, 2013年03月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Effect of low-intensity pulsed ultrasound on bone healing at osteotomy sites after forearm bone shortening.
Atsushi Urita, Norimasa Iwasaki, Makoto Kondo, Yasuhiko Nishio, Tamotsu Kamishima, Akio Minami
The Journal of hand surgery, 38, 3, 498, 503, 2013年03月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Association of Renal Volume with the Degree of Aortic Contrast Enhancement in Abdominal CT　　　　　　　　　　　　　　　
Muto NS, Kamishima T, Sasaki T, Terae S, Tha KK, Shirato H, Bae KT
Advances in Computed Tomography, 2, 55, 62, 2013年, ［査読有り］
英語, 研究論文（学術雑誌）

Contrast-enhanced whole body joint MR Imaging in rheumatoid patients on tumour necrosis factor-alpha agents: a pilot study to evaluate novel scoring system for MR synovitis
T. Kamishima, M. Kato, T. Atsumi, T. Koike, Y. Onodera, S. Terae
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 31, 1, 154, 154, 2013年01月, ［査読有り］
英語

Fat-suppressed MR images of both hands obtained using CHESS can be improved by rice pads.
Susumu Moriya, Yukio Miki, Tamotsu Kamishima, Mitsunori Kanagaki, Tsuneo Yokobayashi, Mitsunori Ishikawa
European journal of radiology, 81, 9, 2318, 22, 2012年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Long-term stress distribution patterns of the ankle joint in varus knee alignment assessed by computed tomography osteoabsorptiometry.
Tomohiro Onodera, Tokifumi Majima, Norimasa Iwasaki, Tamotsu Kamishima, Yasuhiko Kasahara, Akio Minami
International orthopaedics, 36, 9, 1871, 6, 2012年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Alterations in stress distribution patterns through the forearm joint surface of the elbow in baseball players assessed using computed tomography osteoabsorptiometry.
Daisuke Momma, Norimasa Iwasaki, Naomi Oizumi, Kazuhiro Fujisaki, Tadanao Funakoshi, Yuichiro Abe, Tamotsu Kamishima, Shigeru Tadano, Akio Minami
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 17, 3, 253, 60, 2012年05月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Distribution of bone mineral density at osteochondral donor sites in the patellofemoral joint among baseball players and controls.
Kinya Nishida, Norimasa Iwasaki, Kazuhiro Fujisaki, Tadanao Funakoshi, Tamotsu Kamishima, Shigeru Tadano, Akio Minami
The American journal of sports medicine, 40, 4, 909, 14, 2012年04月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

A retrospective evaluation of magnetic resonance imaging effectiveness on capitellar osteochondritis dissecans among overhead athletes.
Norimasa Iwasaki, Tamotsu Kamishima, Hiroyuki Kato, Tadanao Funakoshi, Akio Minami
The American journal of sports medicine, 40, 3, 624, 30, 2012年03月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Usefulness of portography and contrast-enhanced computed tomography to predict the embolized area in percutaneous transhepatic portal vein embolization with absolute ethanol under temporary balloon occlusion
Hasegawa Y, Abo D, Sakuhara Y, Kato F, Kamishima T, Shimizu T, Ito YM, Terae S, Shirato H
Japanese journal of radiology, 30, 1, 53, 61, 2012年01月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）, PURPOSE: To assess the usefulness of portography and contrast-enhanced computed tomography (CECT) for predicting the embolized area after the first injection of absolute ethanol (AE) in right portal vein embolization (RPVE). MATERIALS AND METHODS: Portograms were retrospectively reviewed in 50 patients (30 men and 20 women, mean age 65 years) who had undergone percutaneous transhepatic RPVE with AE under temporary balloon occlusion (TBO) between February 2002 and October 2009. The enhancement pattern before embolization and the embolization pattern after the first AE injection were analyzed by portography. The angles of portal branches against the horizontal plane were measured in 48 patients using pre-treatment CECT. RESULTS: The enhancement pattern was not consistent with the embolization pattern in 35 patients (p < 0.001). When the anterior branch angles were divided into two groups at -5°, 0°, 10°, and 15°, the frequency of the posterior-branch-dominant embolization pattern was higher in the more negatively angled group (p = 0.002-0.041). CONCLUSION: The distribution of AE is different from that of contrast medium in percutaneous transhepatic RPVE under TBO. The pre-treatment measurement of the angles of portal branches against the horizontal plane on CECT is suggested to be useful for predicting the embolized area.

In vivo vascularity alterations in repaired rotator cuffs determined by contrast-enhanced ultrasound.
Tadanao Funakoshi, Norimasa Iwasaki, Tamotsu Kamishima, Mutsumi Nishida, Yoichi Ito, Kinya Nishida, Makoto Motomiya, Naoki Suenaga, Akio Minami
The American journal of sports medicine, 39, 12, 2640, 6, 2011年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Identification and further differentiation of subendocardial and transmural myocardial infarction by fast strain-encoded (SENC) magnetic resonance imaging at 3.0 Tesla.
Noriko Oyama-Manabe, Naoki Ishimori, Hiroyuki Sugimori, Marc Van Cauteren, Kohsuke Kudo, Osamu Manabe, Tomoyuki Okuaki, Tamotsu Kamishima, Yoichi M Ito, Hiroyuki Tsutsui, Khin Khin Tha, Satoshi Terae, Hiroki Shirato
European radiology, 21, 11, 2362, 8, 2011年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVES: To investigate whether subendocardial and transmural myocardial infarction can be identified and differentiated using the peak circumferential and longitudinal strains measured by fast strain-encoded (SENC). METHODS: Nineteen patients with ischemic heart diseases underwent imaging with fast SENC and late gadolinium enhancement (LGE) MRI at 3 T. Fast SENC measurements were performed in three short-axis slices (basal, mid-ventricular and apical levels) and one long-axis view (four-chamber) to assess peak longitudinal and circumferential systolic strains. RESULTS: All patients showed myocardial infarction with an average of 7 positive LGE segments. A total of 304 segments for longitudinal strains (LS) and 114 segments for circumferential strains (CS) could be analysed. Positive LGE segments showed lower peak CS and LS compared with the no LGE segments (P < 0.0001 for both). Segments with subendocardial infarction showed reduced CS and LS compared with the no LGE segments (P < 0.0001 for both). There was a significant difference in CS between subendocardial and transmural infarct segments (P = 0.03), but no significant difference in LS between them (P = 0.64). CONCLUSIONS: Fast SENC can identify old myocardial infarction and differentiate subendocardial from transmural infarction.

Power Doppler signal calibration using capillary phantom for pannus vascularity in rheumatoid finger joint: a pilot study
T. Kamishima, M. Nishida, T. Horie, A. Narita, A. Sagawa, M. Henmi, H. Shirato, S. Terae
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 29, 6, 1057, 1057, 2011年11月, ［査読有り］
英語

Radiographic prognosis of finger joint damage predicted by early alteration in synovial vascularity in patients with rheumatoid arthritis: Potential utility of power doppler sonography in clinical practice
Jun Fukae, Masato Isobe, Akemi Kitano, Mihoko Henmi, Fumihiko Sakamoto, Akihiro Narita, Takeya Ito, Akio Mitsuzaki, Masato Shimizu, Kazuhide Tanimura, Megumi Matsuhashi, Tamotsu Kamishima, Tatsuya Atsumi, Takao Koike
Arthritis Care and Research, 63, 9, 1247, 1253, 2011年09月, ［査読有り］
英語, 研究論文（学術雑誌）

Radiographic prognosis of finger joint damage predicted by early alteration in synovial vascularity in patients with rheumatoid arthritis: Potential utility of power doppler sonography in clinical practice.
Jun Fukae, Masato Isobe, Akemi Kitano, Mihoko Henmi, Fumihiko Sakamoto, Akihiro Narita, Takeya Ito, Akio Mitsuzaki, Masato Shimizu, Kazuhide Tanimura, Megumi Matsuhashi, Tamotsu Kamishima, Tatsuya Atsumi, Takao Koike
Arthritis care & research, 63, 9, 1247, 53, 2011年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

画像診断技術の進歩とその臨床的革新への可能性 造影超音波検査による腱板治癒過程における血行動態の変化
船越 忠直, 岩崎 倫政, 西田 欽也, 本宮 真, 神島 保, 西田 睦, 末永 直樹, 三浪 明男
日本整形外科学会雑誌, 85, 8, S1061, S1061, (公社)日本整形外科学会, 2011年08月
日本語

Rapid estimation of split renal function in kidney donors using software developed for computed tomographic renal volumetry.
Fumi Kato, Tamotsu Kamishima, Ken Morita, Natalia S Muto, Syozou Okamoto, Tokuhiko Omatsu, Noriko Oyama, Satoshi Terae, Kakuko Kanegae, Katsuya Nonomura, Hiroki Shirato
European journal of radiology, 79, 1, 15, 20, 2011年07月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Computed tomography osteoabsorptiometry alterations in stress distribution patterns through the wrist after radial shortening osteotomy for Kienböck disease.
Makabe H, Iwasaki N, Kamishima T, Oizumi N, Tadano S, Minami A
The Journal of hand surgery, 36, 7, 1158, 64, 2011年07月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Monitoring anti-interleukin 6 receptor antibody treatment for rheumatoid arthritis by quantitative magnetic resonance imaging of the hand and power Doppler ultrasonography of the finger.
Tamotsu Kamishima, Kazuhide Tanimura, Masato Shimizu, Megumi Matsuhashi, Jun Fukae, Yujiro Kon, Hiromi Hagiwara, Akihiro Narita, Yuko Aoki, Naoki Kosaka, Tatsuya Atsumi, Hiroki Shirato, Satoshi Terae
Skeletal radiology, 40, 6, 745, 55, 2011年06月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Relationship between diseased lung tissues on computed tomography and motion of fiducial marker near lung cancer.
Yuya Onodera, Noriko Nishioka, Koichi Yasuda, Noriyuki Fujima, Mylin Torres, Tamotsu Kamishima, Noriko Ooyama, Rikiya Onimaru, Satoshi Terae, Satoshi Ooizumi, Masaharu Nishimura, Hiroki Shirato
International journal of radiation oncology, biology, physics, 79, 5, 1408, 13, 2011年04月01日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: For lung cancer patients with poor pulmonary function because of emphysema or fibrosis, it is important to predict the amplitude of internal tumor motion to minimize the irradiation of the functioning lung tissue before undergoing stereotactic body radiotherapy. METHODS AND MATERIALS: Two board-certified diagnostic radiologists independently assessed the degree of pulmonary emphysema and fibrosis on computed tomography scans in 71 patients with peripheral lung tumors before real-time tumor-tracking radiotherapy. The relationships between the computed tomography findings of the lung parenchyma and the motion of the fiducial marker near the lung tumor were investigated. Of the 71 patients, 30 had normal pulmonary function, and 29 had obstructive pulmonary dysfunction (forced expiratory volume in 1 s/forced vital capacity ratio of <70%), 6 patients had constrictive dysfunction (percentage of vital capacity <80%), and 16 had mixed dysfunction. RESULTS: The upper region was associated with smaller tumor motion, as expected (p = .0004), and the presence of fibrosis (p = .088) and pleural tumor contact (p = .086) were weakly associated with tumor motion. The presence of fibrotic changes in the lung tissue was associated with smaller tumor motion in the upper region (p <.05) but not in the lower region. The findings of emphysema and pulmonary function tests were not associated with tumor motion. CONCLUSION: Tumors in the upper lung region with fibrotic changes have smaller motion than those in the upper region of the lungs without fibrotic changes. The tumor motion in the lower lung region was not significantly different between patients with and without lung fibrosis. Emphysema was not associated with the amplitude of tumor motion.

Renal cortical volume measured using automatic contouring software for computed tomography and its relationship with BMI, age and renal function.
Natalia Sayuri Muto, Tamotsu Kamishima, Ardene A Harris, Fumi Kato, Yuya Onodera, Satoshi Terae, Hiroki Shirato
European journal of radiology, 78, 1, 151, 6, 2011年04月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

RELATIONSHIP BETWEEN DISEASED LUNG TISSUES ON COMPUTED TOMOGRAPHY AND MOTION OF FIDUCIAL MARKER NEAR LUNG CANCER
Yuya Onodera, Noriko Nishoka, Koichi Yasuda, Noriyuki Fujima, Mylin Torres, Tamotsu Kamishima, Noriko Ooyama, Rikiya Onimaru, Satoshi Terae, Satoshi Ooizumi, Masaharu Nishimura, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 79, 5, 1408, 1413, 2011年04月, ［査読有り］
英語, 研究論文（学術雑誌）

肩腱板断裂治癒過程における血行動態 新規造影剤を用いた超音波検査　　　　　　　　　　　　　　　
船越 忠直, 岩崎 倫政, 西田 睦, 神島 保, 三浪 明男
北海道整形災害外科学会雑誌, 52, 2, 357, 358, 北海道整形災害外科学会, 2011年03月
日本語

造影超音波検査による肩腱板断裂治癒過程における血行動態の変化
船越 忠直, 岩崎 倫政, 神島 保, 西田 睦, 西田 欽也, 本宮 真, 河村 大介, 松本 大, 永野 裕介, 三浪 明男, 末永 直樹
日本整形外科学会雑誌, 85, 3, S347, S347, (公社)日本整形外科学会, 2011年03月
日本語

Long-term stress distribution patterns across the elbow joint in baseball players assessed by computed tomography osteoabsorptiometry.
Daisuke Momma, Norimasa Iwasaki, Naomi Oizumi, Hiroki Nakatsuchi, Tadanao Funakoshi, Tamotsu Kamishima, Shigeru Tadano, Akio Minami
The American journal of sports medicine, 39, 2, 336, 41, 2011年02月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

The incidence and mechanism of sunitinib-induced thyroid atrophy in patients with metastatic renal cell carcinoma
N. Shinohara, M. Takahashi, T. Kamishima, H. Ikushima, N. Otsuka, A. Ishizu, C. Shimizu, H. Kanayama, K. Nonomura
BRITISH JOURNAL OF CANCER, 104, 2, 241, 247, 2011年01月, ［査読有り］
英語, 研究論文（学術雑誌）

Simplified approach to MR image quantification of the rheumatoid wrist: a pilot study.
Tamotsu Kamishima, Kazuhide Tanimura, Yuko Aoki, Naoki Kosaka, Masato Shimizu, Megumi Matsuhashi, Jun Fukae, Yujiro Kon, Satoshi Terae, Hiroki Shirato
Skeletal radiology, 40, 1, 65, 74, 2011年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

In vivo visualization of vascular patterns of rotator cuff tears using contrast-enhanced ultrasound.
Tadanao Funakoshi, Norimasa Iwasaki, Tamotsu Kamishima, Mutsumi Nishida, Yoichi Ito, Makoto Kondo, Akio Minami
The American journal of sports medicine, 38, 12, 2464, 71, 2010年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Transplantation of tissue-engineered cartilage for the treatment of osteochondritis dissecans in the elbow: outcomes over a four-year follow-up in two patients.
Norimasa Iwasaki, Shintarou Yamane, Kinya Nishida, Tatsuya Masuko, Tadanao Funakoshi, Tamotsu Kamishima, Akio Minami
Journal of shoulder and elbow surgery, 19, 8, e1-6, E6, 2010年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Contrast-enhanced whole-body joint MRI in patients with unclassified arthritis who develop early rheumatoid arthritis within 2 years: feasibility study and correlation with MRI findings of the hands.
Tamotsu Kamishima, Yuichiro Fujieda, Tatsuya Atsumi, Rie Mimura, Takao Koike, Satoshi Terae, Hiroki Shirato
AJR. American journal of roentgenology, 195, 4, W287-92, W292, 2010年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

肩腱板断裂に対する新規造影剤を用いた超音波検査の有用性　　　　　　　　　　　　　　　
船越 忠直, 神島 保, 西田 睦, 近藤 真, 岩崎 倫政, 三浪 明男
北海道整形災害外科学会雑誌, 52, 1, 134, 135, 北海道整形災害外科学会, 2010年08月
日本語

肩腱板断裂治癒過程における血行動態 新規造影剤を用いた超音波検査
船越 忠直, 岩崎 倫政, 西田 欽也, 本宮 真, 神島 保, 西田 睦, 末永 直樹, 三浪 明男
日本整形外科学会雑誌, 84, 8, S1191, S1191, (公社)日本整形外科学会, 2010年08月
日本語

Splenic volume measurements on computed tomography utilizing automatically contouring software and its relationship with age, gender, and anthropometric parameters.
Ardene Harris, Tamotsu Kamishima, Hong Yi Hao, Fumi Kato, Tokuhiko Omatsu, Yuya Onodera, Satoshi Terae, Hiroki Shirato
European journal of radiology, 75, 1, e97-101, E101, 2010年07月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Change of synovial vascularity in a single finger joint assessed by power doppler sonography correlated with radiographic change in rheumatoid arthritis: Comparative study of a novel quantitative score with a semiquantitative score
Jun Fukae, Yujiro Kon, Mihoko Henmi, Fumihiko Sakamoto, Akihiro Narita, Masato Shimizu, Kazuhide Tanimura, Megumi Matsuhashi, Tamotsu Kamishima, Tatsuya Atsumi, Takao Koike
Arthritis Care and Research, 62, 5, 657, 663, 2010年05月, ［査読有り］
英語, 研究論文（学術雑誌）

Extramedullary plasmacytoma involving perirenal space accompanied by extramedullary hematopoiesis and amyloid deposition
Rie Mimura, Tamotsu Kamishima, Kanako C. Kubota, Fumihito Nakano, Ichiro Yabe, Hidenao Sasaki, Satoru Maruyama, Nobuo Shinohara, Ardene A. Harris, Hironori Haga, Hiroki Shirato, Satoshi Terae
JAPANESE JOURNAL OF RADIOLOGY, 28, 4, 309, 313, 2010年05月, ［査読有り］
英語, 研究論文（学術雑誌）

Semi-quantitative analysis of rheumatoid finger joint synovitis using power Doppler ultrasonography: when to perform follow-up study after treatment consisting mainly of antitumor necrosis factor alpha agent.
Tamotsu Kamishima, Akira Sagawa, Kazuhide Tanimura, Masato Shimizu, Megumi Matsuhashi, Masahide Shinohara, Hiromi Hagiwara, Mihoko Henmi, Akihiro Narita, Satoshi Terae, Hiroki Shirato
Skeletal radiology, 39, 5, 457, 65, 2010年05月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Change of synovial vascularity in a single finger joint assessed by power doppler sonography correlated with radiographic change in rheumatoid arthritis: comparative study of a novel quantitative score with a semiquantitative score.
Jun Fukae, Yujiro Kon, Mihoko Henmi, Fumihiko Sakamoto, Akihiro Narita, Masato Shimizu, Kazuhide Tanimura, Megumi Matsuhashi, Tamotsu Kamishima, Tatsuya Atsumi, Takao Koike
Arthritis care & research, 62, 5, 657, 63, 2010年05月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Extramedullary plasmacytoma involving perirenal space accompanied by extramedullary hematopoiesis and amyloid deposition.
Rie Mimura, Tamotsu Kamishima, Kanako C Kubota, Fumihito Nakano, Ichiro Yabe, Hidenao Sasaki, Satoru Maruyama, Nobuo Shinohara, Ardene A Harris, Hironori Haga, Hiroki Shirato, Satoshi Terae
Japanese journal of radiology, 28, 4, 309, 13, 2010年05月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

造影超音波を用いた断裂および非断裂棘上筋の血行動態
船越 忠直, 岩崎 倫政, 三浪 明男, 神島 保, 西田 睦, 近藤 真
日本整形外科学会雑誌, 84, 3, S68, S68, (公社)日本整形外科学会, 2010年03月
日本語

造影超音波による関節リウマチの活動性評価　　　　　　　　　　　　　　　
神島 保, 西田 睦, 渥美 達也
IVR: Interventional Radiology, 25, 1, 109, 109, (一社)日本インターベンショナルラジオロジー学会, 2010年01月
日本語

Sequential alterations in magnetic resonance imaging findings after autologous osteochondral mosaicplasty for young athletes with osteochondritis dissecans of the humeral capitellum.
Norimasa Iwasaki, Hiroyuki Kato, Tamotsu Kamishima, Akio Minami
The American journal of sports medicine, 37, 12, 2349, 54, 2009年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Intravenous pyogenic granuloma of the finger.
Tamotsu Kamishima, Akiko Hasegawa, Kanako C Kubota, Naomi Oizumi, Norimasa Iwasaki, Akio Minami, Satoru Sasaki, Yuhei Yamamoto, Tokuhiko Omatsu, Yuya Onodera, Satoshi Terae, Hiroki Shirato
Japanese journal of radiology, 27, 8, 328, 32, 2009年10月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Alveolar hydatid disease of the adrenal gland: computed tomography and magnetic resonance imaging findings
Tamotsu Kamishima, Toru Harabayashi, Syuhei Ishikawa, Kanako C. Kubota, Katsuya Nonomura, Tokuhiko Omatsu, Yuya Onodera, Hiroki Shirato, Satoshi Terae
JAPANESE JOURNAL OF RADIOLOGY, 27, 5, 225, 228, 2009年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Alveolar hydatid disease of the adrenal gland: computed tomography and magnetic resonance imaging findings.
Tamotsu Kamishima, Toru Harabayashi, Syuhei Ishikawa, Kanako C Kubota, Katsuya Nonomura, Tokuhiko Omatsu, Yuya Onodera, Hiroki Shirato, Satoshi Terae
Japanese journal of radiology, 27, 5, 225, 8, 2009年06月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Power Doppler ultrasound of rheumatoid synovitis: quantification of vascular signal and analysis of interobserver variability.
Tamotsu Kamishima, Kazuhide Tanimura, Mihoko Henmi, Akihiro Narita, Fumihiko Sakamoto, Satoshi Terae, Hiroki Shirato
Skeletal radiology, 38, 5, 467, 72, 2009年05月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Synovial chondromatosis originating from the synovium of the anterior cruciate ligament: a case report.
Tokifumi Majima, Tamotsu Kamishima, Kouichi Susuda
Sports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT, 1, 1, 6, 6, Springer Science and Business Media LLC, 2009年04月23日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, A case of synovial chondromatosis originating from the synovium of the anterior cruciate ligament (ACL) resulting in a mechanical block to knee extension is reported. A 36-year-old man complained of a restricted range of left-knee motion and pain when walking. Plain roentgenograms showed normal appearance, however, magnetic resonance imaging showed intensity changes in the ACL. Arthroscopically, numerous small free bodies were observed. Proliferation of synovium and cartilaginous tissues were identified around the ACL. There were no significant findings in the synovium except around the ACL. The synovium around the ACL was resected and free bodies were washed out. This is the first report of synovial chondromatosis originating from the synovium of the ACL.

RA患者における手関節造影MRIを用いた炎症性滑膜定量による生物学的製剤の効果判定　　　　　　　　　　　　　　　
神島 保, 堀田 哲也, 大友 耕太郎, 藤枝 雄一郎, 片岡 浩, 保田 晋助, 加藤 将, 渥美 達也, 小池 隆夫
日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 53回・18回, 397, 397, (一社)日本リウマチ学会, 2009年03月
日本語

Screening for rheumatoid arthritis with finger joint power Doppler ultrasonography: quantification of conventional power Doppler ultrasonographic scoring.
Jun Fukae, Masato Shimizu, Yujiro Kon, Kazuhide Tanimura, Megumi Matsuhashi, Tamotsu Kamishima, Takao Koike
Modern rheumatology, 19, 5, 502, 6, 2009年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

CT/MRIにて確定診断に至らなかった結節に対する造影超音波(CEUS)の位置づけ　　　　　　　　　　　　　　　
西田 睦, 増田 香織, 佐藤 恵美, 溝口 恵美, 小野寺 祐也, 尾松 徳彦, 神島 保, 加藤 扶美, 加賀 早苗, 井上 真美子, 横山 しのぶ, 鈴木 春樹, 清水 力, 松野 一彦, 玉木 長良, 白土 博樹
超音波医学, 35, 4, 463, 463, (公社)日本超音波医学会, 2008年07月
日本語

全身造影MRIによる関節リウマチの画像診断　　　　　　　　　　　　　　　
神島 保, 白土 博樹, 保田 晋介, 堀田 哲也, 渥美 達也, 小池 隆夫
Radiation Medicine, 26, Suppl.I, 11, 11, (公社)日本医学放射線学会, 2008年04月
日本語

Donor site evaluation after autologous osteochondral mosaicplasty for cartilaginous lesions of the elbow joint.
Norimasa Iwasaki, Hiroyuki Kato, Tamotsu Kamishima, Naoki Suenaga, Akio Minami
The American journal of sports medicine, 35, 12, 2096, 100, 2007年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

関節リウマチの画像診断 非造影関節エコーによる関節リウマチの関節炎評価　　　　　　　　　　　　　　　
櫻井 典之, 深江 淳, 渥美 達也, 酒井 良江, 堀田 哲也, 保田 晋助, 神島 保, 小池 隆夫
日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 50回・15回, 132, 132, (一社)日本リウマチ学会, 2006年03月
日本語

Chemical shift MR images of the parotid gland in Sjögren's syndrome utilizing low-field MR system comparison with MR sialography and salivary secretion function.
Kamishima T
Radiation medicine, 23, 4, 277, 82, 2005年06月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

Detection of amiodarone-induced pulmonary toxicity in supine and prone positions: high-resolution computed tomography study.
Noriko Oyama, Naotsugu Oyama, Hisashi Yokoshiki, Tamotsu Kamishima, Toshikazu Nambu, Hiroyuki Tsutsui, Kazuo Miyasaka
Circulation journal : official journal of the Japanese Circulation Society, 69, 4, 466, 70, 2005年04月, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）

MDCT scan visualizes the Adamkiewicz artery.
Ryushi Maruyama, Tamotsu Kamishima, Norihiko Shiiya, Takeshi Asano, Kenji Matsuzaki, Kazuo Miyasaka, Keishu Yasuda
The Annals of thoracic surgery, 76, 4, 1308, 1308, 2003年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Acute posterior interosseous nerve palsy caused by septic arthritis of the elbow: a case report.
Hiroyuki Kato, Norimasa Iwasaki, Akio Minami, Tamotsu Kamishima
The Journal of hand surgery, 28, 1, 44, 7, 2003年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Cirrhosis: modified caudate-right lobe ratio.
Hitomi Awaya, Donald G Mitchell, Tamotsu Kamishima, George Holland, Katsuyoshi Ito, Tsuneo Matsumoto
Radiology, 224, 3, 769, 74, 2002年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Small (<20 mm) enhancing hepatic nodules seen on arterial phase MR imaging of the cirrhotic liver: clinical implications.
Yong Yeon Jeong, Donald G Mitchell, Tamotsu Kamishima
AJR. American journal of roentgenology, 178, 6, 1327, 34, 2002年06月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Spontaneous rupture of hepatocellular carcinoma supplied by the right renal capsular artery treated by transcatheter arterial embolization
Y Kodama, T Shimizu, H Endo, S Hige, T Kamishima, GA Holland, N Miyamoto, K Miyasaka
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 25, 2, 137, 140, 2002年03月, ［査読有り］
英語, 研究論文（学術雑誌）

Elbow synovial fold syndrome: MR imaging findings
H Awaya, ME Schweitzer, SA Feng, T Kamishima, PJ Marone, S Farooki, DJ Trudell, P Haghighi, DL Resnick
AMERICAN JOURNAL OF ROENTGENOLOGY, 177, 6, 1377, 1381, 2001年12月, ［査読有り］
英語, 研究論文（学術雑誌）

Rapid MR imaging detection of renal cysts: Age-based standards
AB Nascimento, DG Mitchell, XM Zhang, T Kamishima, L Parker, GA Holland
RADIOLOGY, 221, 3, 628, 632, 2001年12月, ［査読有り］
英語, 研究論文（学術雑誌）

Utilization of "used" vials: Cost-effective technique for MR arthrography
T Kamishima, ME Schweitzer, H Awaya, D Abraham
JOURNAL OF MAGNETIC RESONANCE IMAGING, 12, 6, 953, 955, 2000年12月, ［査読有り］
英語, 研究論文（学術雑誌）

MR imaging of bilateral renal malacoplakia after liver transplantation
T Kamishima, K Ito, H Awaya, DG Mitchell
AMERICAN JOURNAL OF ROENTGENOLOGY, 175, 3, 919, 920, 2000年09月, ［査読有り］
英語, 研究論文（学術雑誌）

生体部分肝移植におけるVascular IVRの経験　　　　　　　　　　　　　　　
作原 祐介, 児玉 芳尚, 立石 宇貴秀, 神島 保, 清水 匡, 宮坂 和男
日本医学放射線学会雑誌, 60, 3, 113, 113, (公社)日本医学放射線学会, 2000年02月
日本語

自己免疫性肝硬変に合併した多発AVFの治療経験　　　　　　　　　　　　　　　
立石 宇貴秀, 作原 祐介, 児玉 芳尚, 神島 保, 清水 匡, 宮坂 和男
日本医学放射線学会雑誌, 60, 3, 113, 113, (公社)日本医学放射線学会, 2000年02月
日本語

信頼性指標を用いたRA患者の関節破壊を検出するための自動インハウスソフトウェアの最適化【JST・京大機械翻訳】|||
OKINO Taichi, OKINO Taichi, OU Yafei, IKEBE Masayuki, SAGAWA Akira, KATO Masaru, ATSUMI Tatsuya, KAMISHIMA Tamotsu, 日本医学物理学会学術大会報文集, 123rd, 2022年

RA患者の関節破壊を検出する自動インハウスソフトの信頼性指標を用いた最適化
OKINO Taichi, OKINO Taichi, OU Yafei, IKEBE Masayuki, SAGAWA Akira, KATO Masaru, ATSUMI Tatsuya, KAMISHIMA Tamotsu, 日本放射線技術学会総会学術大会予稿集, 78th, 2022年

RAにおける指JSN進行の検出のためのPOC分析への信頼性指標の適用
AN Yujie, KAWADA Seiya, OU Yafei, IKEBE Masayuki, FURUSAKI Akira, SAGAWA Akira, KAMISHIMA Tamotsu, 日本医学放射線学会総会抄録集, 81st, 2022年

自動部分画像位相のみ相関解析は関節リウマチにおけるX線指関節腔狭窄を検出できる【JST・京大機械翻訳】|||
OKINO Taichi, OU Yafei, IKEBE Masayuki, FUKAE Jun, TANIMURA Kazuhide, KAMISHIMA Tamotsu, 日本医学物理学会学術大会報文集, 121st, 2021年

関節リウマチにおけるX線指関節腔狭窄の検出における位相限定相関(POC)解析の落とし穴
AN Yujie, ZENG Tianyu, OU Yafei, IKEBE Masayuki, FURUSAKI Akira, SAGAWA Akira, KAMISHIMA Tamotsu, 日本医学放射線学会総会抄録集, 80th, 2021年

自動部分画像位相のみ相関解析は関節リウマチにおけるX線指関節裂隙狭小化を検出できる
OKINO Taichi, OU Yafei, IKEBE Masayuki, FUKAE Jun, TANIMURA Kazuhide, KAMISHIMA Tamotsu, 日本放射線技術学会総会学術大会予稿集, 77th, 2021年

Convolutional neural network for classification of two-dimensional array images generated from clinical information may support diagnosis of rheumatoid arthritis.
Jun Fukae, Masato Isobe, Toshiyuki Hattori, Yuichiro Fujieda, Michihiro Kono, Nobuya Abe, Akemi Kitano, Akihiro Narita, Mihoko Henmi, Fumihiko Sakamoto, Yuko Aoki, Takeya Ito, Akio Mitsuzaki, Megumi Matsuhashi, Masato Shimizu, Kazuhide Tanimura, Kenneth Sutherland, Tamotsu Kamishima, Tatsuya Atsumi, Takao Koike, Scientific reports, 10, 1, 5648, 5648, 2020年03月27日, ［国際誌］
This research aimed to study the application of deep learning to the diagnosis of rheumatoid arthritis (RA). Definite criteria or direct markers for diagnosing RA are lacking. Rheumatologists diagnose RA according to an integrated assessment based on scientific evidence and clinical experience. Our novel idea was to convert various clinical information from patients into simple two-dimensional images and then use them to fine-tune a convolutional neural network (CNN) to classify RA or nonRA. We semi-quantitatively converted each type of clinical information to four coloured square images and arranged them as one image for each patient. One rheumatologist modified each patient's clinical information to increase learning data. In total, 1037 images (252 RA, 785 nonRA) were used to fine-tune a pretrained CNN with transfer learning. For clinical data (10 RA, 40 nonRA), which were independent of the learning data and were used as testing data, we compared the classification ability of the fine-tuned CNN with that of three expert rheumatologists. Our simple system could potentially support RA diagnosis and therefore might be useful for screening RA in both specialised hospitals and general clinics. This study paves the way to enabling deep learning in the diagnosis of RA., 英語

小関節をシミュレートするファントムにおける関節腔の定量評価:位相限定相関(POC)を用いたX線撮影の高性能CTと比較した妥当性
TAGUCHI Aimi, SHISHIDO Shun, OU Yafei, YASOJIMA Nobutoshi, TAMURA Kenichi, IKEBE Masayuki, KAMISHIMA Tamotsu, 日本放射線技術学会総会学術大会予稿集, 76th, 2020年

指関節腔狭小化の微細な変化の検出感度におけるX線撮影とトモシンセシスの比較:水中ファントムのPOC分析
ZENG Tianyu, KONDO Mana, YASOJIMA Nobutoshi, TAMURA Kenichi, OU Yafei, IKEBE Masayuki, KAMISHIMA Tamotsu, 日本放射線技術学会総会学術大会予稿集, 76th, 2020年

リウマチ患者における位相限定相関法(POC)による指関節腔狭小化の自動分析
OKINO Taichi, OU Yafei, IKEBE Masayuki, FUKAE Jun, TANIMURA Kazuhide, KAMISHIMA Tamotsu, 日本放射線技術学会総会学術大会予稿集, 76th, 2020年

リウマチ患者の位相限定相関法(POC)による自動指関節腔狭小化解析
OKINO Taichi, OU Yafei, IKEBE Masayuki, FUKAE Jun, TANIMURA Kazuhide, KAMISHIMA Tamotsu, 日本医学物理学会学術大会報文集, 119th, 2020年

ファントム模擬的小関節における関節腔の定量評価:高性能CTと比較した位相限定相関法(POC)を用いた放射線写真の妥当性
TAGUCHI Aimi, SHISHIDO Shun, OU Yafei, YASOJIMA Nobutoshi, TAMURA Kenichi, IKEBE Masayuki, KAMISHIMA Tamotsu, 日本医学物理学会学術大会報文集, 119th, 2020年

指関節腔狭小化の微小変化に対する検出脳における放射線写真とトモシンセシスとの比較:水タンク中のファントムのPOC解析
ZENG Tianyu, KONDO Mana, YASOJIMA Nobutoshi, TAMURA Kenichi, OU Yafei, IKEBE Masayuki, KAMISHIMA Tamotsu, 日本医学物理学会学術大会報文集, 119th, 2020年

MRIで米粒体を認めた全身性エリテマトーデス患者の非結核性抗酸菌性腱鞘滑膜炎の1例
蜷川慶太, 藤枝雄一郎, 松井雄一郎, 神島保, 麻生邦之, 佐藤太貴, 河野通仁, 加藤将, 奥健志, OLGA Amengual, 保田晋助, 岩崎倫政, 渥美達也, 日本臨床免疫学会総会プログラム・抄録集, 47th, 2019年

人の目とソフトウェアにおける関節リウマチ患者の微小関節裂隙狭小化の検出能の比較
加藤一樹, 本郷七瀬, 八十嶋伸敏, 田村賢一, 市川翔太, SUTHERLAND Kenneth, 神島保, 北海道医学雑誌, 94, 1, 2019年

X線画像診断に向けた定量的サブピクセル関節破壊量計測
池辺将之, YAFEI Ou, AMBALATHANKANDY Prasoon, 神島保, 映像情報メディア学会技術報告, 43, 36(IST2019 53-58), 2019年

リウマチ性疾患の画像2:関節エコーその他 超高周波プローブを用いたSuperb Micro-vascular Imagingによる超音波検査でのラット足関節の早期関節炎診断　　　　　　　　　　　　　　　
西田 睦, 谷村 瞬, 神島 保, 西端 友香, 益田 紗季子, 中沢 大悟, 外丸 詩野, 渥美 達也, 石津 明洋, 日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 485, 485, 2018年03月
(一社)日本リウマチ学会, 日本語

スタチンの関節炎抑制効果とその機序の解明　　　　　　　　　　　　　　　
谷村 瞬, 西田 睦, 神島 保, 西端 友香, 益田 紗季子, 中沢 大悟, 外丸 詩野, 渥美 達也, 石津 明洋, 日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 778, 778, 2018年03月
(一社)日本リウマチ学会, 日本語

ダイナミックMRIによる手関節リウマチ滑膜炎の定量化
小林勇渡, 田口愛望, 杉森博之, 神島保, 市川翔太, SUTHERLAND Kenneth, 野口淳史, 河野通仁, 渥美達也, 北海道医学雑誌, 93, 2, 2018年

全自動解析ソフトウェアによるリウマチ患者の関節裂隙狭小化進行評価
田中悠貴, 近藤麻菜, 市川翔太, 神島保, 高橋英治, 古崎章, 天崎吉晴, 北海道医学雑誌, 93, 2, 2018年

スタチンの関節炎抑制効果と機序の検討
谷村瞬, 渥美達也, 西田睦, 堀江達則, 神島保, 玉井絵里香, 森村豊, 西端友香, 益田紗季子, 石津明洋, 外丸詩野, 北海道医学雑誌, 93, 2, 2018年

関節リウマチにおける造影ダイナミックMRIを用いた滑膜炎定量評価
小林 勇渡, 市川 翔太, 神島 保, 杉森 博行, 野口 淳史, 河野 通仁, 渥美 達也, 北海道医学雑誌, 92, 2, 108, 109, 2017年11月
北海道医学会, 日本語

Assessment of Knee Cartilage Volume Using an Original Software for Conventional MRI(和訳中)
宍戸 駿, 神島 保, 加藤 一樹, 市川 翔太, 近藤 英司, 小野寺 智洋, 日本放射線技術学会雑誌, 73, 9, 867, 867, 2017年09月
(公社)日本放射線技術学会, 英語

従来型MRIに対応した独自のソフトウエアを用いた膝軟骨体積の評価(Assessment of Knee Cartilage Volume Using an Original Software for Conventional MRI)　　　　　　　　　　　　　　　
宍戸 駿, 神島 保, 加藤 一樹, 市川 翔太, 近藤 英司, 小野寺 智洋, 日本放射線技術学会雑誌, 73, 9, 867, 867, 2017年09月
(公社)日本放射線技術学会, 英語

X線画像解析に基づく腰部3次元動作と腰仙椎アライメントとの関係
土谷圭央, 日下聖, 田中孝之, 松尾祥和, 小田まこと, 笹木工, 神島保, 山中正紀, 日本機械学会ロボティクス・メカトロニクス講演会講演論文集(CD-ROM), 2017, ROMBUNNO.2P2‐J06, J06, 2017年05月09日

Anteflexion motion is absolutely necessary when we spend daily life which we carry, snow shoveling, farm work, etc. This study aims to develop of wearable sensor system, and propose an estimation method of lumbosacral alignment and lumbar load caused by changes in posture. Lumbar motion have anteflexion,rotation motion and lateral bending. However, it thing don't know that relationship between the upper body attitude angle and the attitude angle of the vertebral body in rotation motion and lateral bending. We construct that estimation method of rotation angle and lateral bending angle in the vertebral body.

, 一般社団法人 日本機械学会, 日本語

関節リウマチ患者の関節裂隙狭小化進行評価を可能にするオリジナルソフトウェア開発-非専門医による再現性の調査-
波多野克哉, 市川翔太, 神島保, 加藤將, 中川育磨, 渥美達也, 齋藤翔太, 川内敬介, SUTHERLAND Kenneth, 貴志孝行, 寺江聡, 向井正也, 北海道医学雑誌, 92, 2, 2017年

スタチン製剤の関節炎抑制効果と機序の検討
谷村瞬, 渥美達也, 西田睦, 堀江達則, 神島保, 齋藤克己, 西端友香, 益田紗季子, 石津明洋, 外丸詩野, 北海道医学雑誌, 92, 2, 2017年

知っておきたい関節リウマチの診断から治療まで MRIの有用性
保田晋助, 神島保, 診断と治療, 104, 12, 1525‐1529, 1494, 2016年12月01日
診断と治療社, 日本語

ウェアラブルセンサシステムを用いた腰部負荷推定のための腰仙部寸法校正法
土谷圭央, 日下聖, 田中孝之, 松尾祥和, 小田まこと, 笹木工, 神島保, 山中正紀, 計測自動制御学会システム・情報部門学術講演会講演論文集(CD-ROM), 2015, ROMBUNNO.SS18-5(O1-2), 2015年11月18日
日本語

1P1-X04 ウェアラブル腰部負荷推定システムのための腰仙部寸法校正法
土谷 圭央, 日下 聖, 田中 孝之, 松尾 祥和, 小田 まこと, 笹木 工, 神島 保, 山中 正紀, ロボティクス・メカトロニクス講演会講演概要集, 2015, "1P1, X04(1)"-"1P1-X04(4)", 2015年05月17日
This study is aimed to developed of wearable sensor system, and propose an estimation method of lumbosacral alignment and lumbar load caused by changes in posture. Obtains the lumbosacral size from the X-ray image, the lumbosacral size calibration method is developed using the body surface area and height. Using these method, and confirm lumbosacral alignment estimation accuracy and the lumbar load estimation accuracy., 一般社団法人日本機械学会, 日本語

生物学的製剤を投与されている関節リウマチ患者の評価のための全身MRIの有用性
KONO Michihito, KONO Michihito, YASUDA Shinsuke, OHMURA Kazumasa, SHIMAMURA Sanae, NOGUCHI Atsushi, NAKAGAWA Ikuma, SHIDA Haruki, WATANABE Toshiyuki, SHIMIZU Yuka, OKU Kenji, BOHGAKI Toshiyuki, AMENGUAL Olga, HORITA Tetsuya, KAMISHIMA Tamotsu, ATSUMI Tatsuya, 日本リウマチ学会総会・学術集会プログラム・抄録集, 59th, 2015年

スポーツ選手における膝蓋大腿関節応力分布の解析―mosaicplastyにおける骨軟骨柱ドナー部位選択のために―
西田欽也, 岩崎倫政, 藤崎和弘, 船越忠直, 神島保, 但野茂, 三浪明男, 北海道整形災害外科学会雑誌, 55, 2, 187, 192, 2014年03月25日
日本語

単純X線写真に対する経時差分技術を用いたリウマチ患者の関節裂隙狭小化評価-手根部関節への応用
市川翔太, 神島保, 佐々木亮祐, SUTHERLAND Kenneth, 大久保学宣, 片山耕, 日本放射線技術学会雑誌, 70, 9, 2014年

単純X線写真におけるリウマチ患者の関節裂隙狭小化の変化-経時差分技術を用いた検討
佐々木亮祐, 神島保, 市川翔太, SUTHERLAND Kenneth, 大久保学宣, 片山耕, 日本放射線技術学会雑誌, 70, 9, 2014年

手関節のリウマチ滑膜炎におけるPixel-by-Pixel TIC解析
坂下太郎, 神島保, 杉森博行, 唐明輝, 河野通仁, 渥美達也, 日本放射線技術学会雑誌, 70, 9, 2014年

多時相造影MRIのTIC解析を用いた滑膜炎抽出
小野雅人, 神島保, 杉森博行, 唐明輝, 河野通仁, 渥美達也, 北海道医学雑誌, 89, 1, 2014年

胸骨正中切開後の慢性胸骨骨髄炎における画像診断（MRIの有用性）
藤井 美樹, 寺師 浩人, 神島 保, 長田 周治, 青木 隆敏, 安田 浩, 創傷, 5, 3, 108, 117, 2014年
胸骨骨髄炎の治療ではデブリドマンが重要であり，術前に壊死・感染組織の範囲を把握しておかなければならない。慢性骨髄炎に対する画像診断手段としてMRIが有用であることは知られているが，胸骨骨髄炎の治癒過程におけるMR画像の経時的変化を詳細に述べた報告はない。われわれの経験した2例の胸骨正中切開後の慢性胸骨骨髄炎患者のMR画像につき詳細を述べる。骨髄炎では，骨髄内の組織液量の増加によりT1強調像で低信号，STIR像で高信号を示す。しかし，欠損部位が肉芽に置き換わり，炎症が鎮静化すると病変部のMRI信号は低下した。また，腐骨となった場合にはMRIのみでの診断はむずかしく，撮影条件の工夫やCTの併用が必要と考えられた。, Japan Society for Surgical Wound Care, 日本語

超音波装置を用いた足関節に対する前方引き出し負荷と移動距離計測の試み　　　　　　　　　　　　　　　
中谷 詩世, 福良 沙霧, 寒川 美奈, 神島 保, 遠山 晴一, 堤 香織, 北海道放射線技術雑誌, 75, 116, 116, 2013年10月
(公社)日本放射線技術学会-北海道部会, 日本語

関節リウマチの滑膜血流評価のための超音波用毛細血管ファントムの検討
神島 保, 西田 睦, 堀江 達則, 坂野 稜典, 成田 明宏, 逸見 美穂子, 谷村 一秀, 佐川 昭, 白土 博樹, 寺江 聡, 北海道醫學雜誌 = Acta medica Hokkaidonensia, 88, 2, 82, 82, 2013年04月01日
日本語

DIAGNOSTIC SENSITIVITY FOR HEPATOCELLULAR CARCINOMA WITH GD-EOB-DTPA-ENHANCED LIVER MRI AND SONAZOID CONTRAST-ENHANCED ULTRASOUND: COMPARISON WITH 64-SLICE MULTIDETECTOR HELICAL CT
J. Ma, Y. Onodera, M. Nishida, T. Kamishima, H. Shirato, W. Loo, EUROPEAN JOURNAL OF CANCER, 49, S1, S2, 2013年03月
英語, 研究発表ペーパー・要旨（国際会議）

感染症の治療戦略 感染症の画像診断
神島保, 真鍋治, 寺江聡, 玉木長良, 整形・災害外科, 55, 6, 717-723, 723, 2012年05月01日
金原出版, 日本語

高機能ゲルを応用した自然再生羊膝軟骨のMR画像評価
神島保, 寺江聡, 白土博樹, 北村信人, 安田和則, Jpn J Radiol, 30, Supplement 1, 10, 2012年02月25日
日本語

関節リウマチの全身関節造影MR診断—段階的滑膜炎評価の試み
神島保, 寺江聡, 白土博樹, 加藤将, 藤枝雄一郎, 渥美達也, 小池隆夫, Jpn J Radiol, 30, Supplement 1, 2, 2012年02月25日
日本語

末梢TFCC断裂のMR診断
神島保, 寺江聡, 白土博樹, 岩崎倫政, 三浪明男, Jpn J Radiol, 30, Supplement 1, 2, 2012年02月25日
日本語

超音波による関節リウマチの炎症性滑膜定量評価—機種間キャリブレーションに関する毛細血管フアントムを用いた基礎的検討
神島保, 寺江聡, 白土博樹, 堀江達則, 西田睦, Jpn J Radiol, 30, Supplement 1, 10, 10, 2012年02月25日
(公社)日本医学放射線学会, 日本語

Long-term stress distribution patterns across the elbow joint in baseball players assessed by computed tomography osteoabsorptiometry (vol 39, pg 336, 2011)
D. Momma, N. Iwasaki, N. Oizumi, H. Nakatsuchi, T. Funakoshi, T. Kamishima, S. Tadano, A. Minami, AMERICAN JOURNAL OF SPORTS MEDICINE, 40, 1, NP4, NP4, 2012年01月
英語, その他

リウマチ画像の定量化 : その進歩と今後の展望(特別講演)
神島 保, 電子情報通信学会技術研究報告. MI, 医用画像, 111, 127, 37, 40, 2011年07月05日
関節リウマチ(RA)は慢性の炎症性疾患で,進行すると関節破壊に至ることもある.近年,RA診療の現場では,抗リウマチ薬に加え強力な治療効果を有する薬剤(生物学的製剤)が使用可能になり,完治に近い状態まで炎症が改善する症例も経験されるようになってきた.それとともに,RAの早期治療開始のために正確な早期診断の必要性が高まっている.画像診断の長所として,定性的評価のみならず定量的評価が可能なことがあげられる.ここでは超音波とMRIのRA病変定量化の進歩につき述べる., 一般社団法人電子情報通信学会, 日本語

新しい医療技術 造影超音波による組織血流測定
船越 忠直, 岩崎 倫政, 神島 保, 整形・災害外科, 54, 8, 963, 968, 2011年07月
金原出版, 日本語

関節リウマチ患者の手指関節超音波検査 (ここまでわかる!! 関節疾患の画像診断)
神島 保, 整形・災害外科, 54, 5, 485, 489, 2011年04月
金原出版, 日本語

非浸潤性乳管癌の3T MRIにおける画像所見の検討
加藤扶美, 大山徳子, 細田充主, 寺江聡, 高橋弘昌, 水戸寿々子, 石坂欣也, 小野寺祐也, 神島保, 白土博樹, 日本医学放射線学会総会抄録集, 70th, S311, 2011年02月28日
日本語

関節リウマチにおける手・手指MRI所見と全身MRI所見との関係
神島保, 小野寺祐也, 寺江聡, 白土博樹, 藤枝雄一郎, 堀田哲也, 渥美達也, 小池隆夫, Jpn J Radiol, 29, Supplement 1, 13, 13, 2011年01月25日
(公社)日本医学放射線学会, 日本語

腎周囲腔原発形質細胞腫の1例
森田亮, 神島保, 白土博樹, 寺江聡, 久保田佳奈子, 中野史人, 矢部一郎, 丸山覚, 三村理恵, Jpn J Radiol, 29, Supplement 1, 3, 2011年01月25日
日本語

肝ダイナミックCT後期動脈相における動脈の造影効果と単純CTから推測される腎体積との関係
神島保, 武藤ナタリア早百合, 加藤扶美, 小野寺祐也, 寺江聡, 白土博樹, 伊藤和夫, Jpn J Radiol, 29, Supplement 1, 9, 2011年01月25日
日本語

デジタルハンドにおける操作力推定の為の指の生体力学モデルの構築
清水 康友, 金井 理, 伊達 宏昭, 白土 博樹, 神島 保, 荻子 仁泰, 精密工学会学術講演会講演論文集, 2011, 0, 107, 108, 2011年
製品設計の為のデジタルハンドを用いた仮想エルゴノミック評価を行う際に，製品の把持や操作の為の手指の力を推定することは，この評価を合理的に行う基準として非常に有効である．本報告では，その評価を行う為の指の筋骨格の生体力学モデルを構築する為，製品把持時の指の腱，筋肉，関節表面に発揮される力を非線形最適化手法により導出する手法を提案する．更に，過去に発表された論文における実験結果と比較し，検証を行う．, The Japan Society for Precision Engineering

全身MRIによる関節リウマチの治療効果判定
神島保, 尾松徳彦, 小野寺祐也, 白土博樹, 寺江聡, 堀田哲也, 渥美達也, 小池隆夫, Jpn J Radiol, 28, Supplement 1, 14, 14, 2010年07月25日
(公社)日本医学放射線学会, 日本語

手指のintravascular pyogenic granulomaの2例
長谷川晶子, 神島保, 尾松徳彦, 小野寺祐也, 寺江聡, 白土博樹, 久保田加奈子, Jpn J Radiol, 28, Supplement 1, 5, 2010年07月25日
日本語

腫瘍におけるtumor doubling timeと糖代謝能の関係
坂本圭太, 神島保, 尾松徳彦, 小野寺祐也, 白土博樹, 寺江聡, 平田健司, 玉木長良, Jpn J Radiol, 28, Supplement 1, 12, 2010年07月25日
日本語

CT造影効果と腎体積の関係
神島保, 武藤ナタリア早百合, 加藤扶美, 尾松徳彦, 小野寺祐也, ハリス アーディンA, 白土博樹, 寺江聡, 伊藤和夫, Jpn J Radiol, 28, Supplement 1, 9, 2010年07月25日
日本語

子宮筋腫核出,帝切後に子宮に発生した腫瘤の1例
相山健, 尾松徳彦, 加藤扶美, 大山徳子, 神島保, 小野寺祐也, 寺江聡, 白土博樹, 蝦名康彦, 櫻木範明, Jpn J Radiol, 28, Supplement 1, 5, 2010年07月25日
日本語

3T MRIにおけるDCISの画像所見
加藤扶美, 大山徳子, 高橋將人, 高橋弘昌, 細田充主, 水戸寿々子, 石坂欣也, 小野寺祐也, 神島保, 寺江聡, 白土博樹, 日本乳癌学会学術総会プログラム・抄録集, 18th, 562, 2010年05月25日
日本語

The incidence and the mechanism of sunitinib-induced thyroid atrophy in patients with metastatic renal cell carcinoma
N. Shinohara, M. Takahashi, T. Kamishima, H. Ikushima, N. Otsuka, A. Ishizu, A. Sazawa, H. Kanayama, K. Nonomura, JOURNAL OF CLINICAL ONCOLOGY, 28, 15, 2010年05月
英語, 研究発表ペーパー・要旨（国際会議）

Experimental MR imaging of zirconia ceramic joint implants at 1.5 and 3 T.
KAMISHIMA T, KITAMURA N, AMEMIYA M, ISHIZAKA K, KATO F, YASUDA K, SHIRATO H, TERAE S, Clin Radiol., 65, 5, 387, 390, 2010年05月01日
Elsevier, 英語

3T乳腺MRIにおけるSplit Dynamic法の検討:Dynamic studyの途中の高分解能撮像と従来法の比較
加藤扶美, 大山徳子, 水戸寿々子, 高橋將人, 坂元哲郎, VAN CAUTEREN Marc, 小野寺祐也, 神島保, 寺江聡, 白土博樹, 日本医学放射線学会総会抄録集, 69th, S256, 2010年02月28日
日本語

CT/MRI (腎細胞がんの治療をめぐって) -- (見落としのない検査のために--腎細胞がんを念頭においた読影)
神島 保, 臨床腫瘍プラクティス, 6, 1, 24, 30, 2010年
ヴァン・メディカル, 日本語

関節リウマチMRIの最前線 : 撮像法とリウマチ医の知りたいことについて
神島 保, 日本磁気共鳴医学会雑誌, 29, 4, 155, 162, 2009年11月15日
日本語

Predominant tubulointerstitial nephritis in a patient with systemic lupus erythematosus with an emphasis on CT and MR imaging findings
Tamotsu Kamishima, Noriko Nishioka, Hiroshi Kataoka, Jun Fukae, Tatsuya Atsumi, Ardene A. Harris, Tokuhiko Omatsu, Yuya Onodera, Satoshi Terae, Hiroki Shirato, European Journal of Radiology Extra, 72, 2009年11月01日

Splenic volume in systemic lupus erythematosus.
Ardene A. Harris, T. Kamishima, T. Horita, T. Atsumi, N. Fujita, T. Omatsu, Y. Onodera, S. Terae, T. Koike, H. Shirato, Lupus., 18(12), 1119, 1120, 2009年10月05日

特別座談会 RA画像診断における造影MRI検査
上谷 雅孝, 青木 隆敏, 神島 保, 映像情報medical, 41, 11, 1074, 1077, 2009年10月
産業開発機構, 日本語

腎癌患者へのSunitinib投与が引き起こす甲状腺機能障害の発症機序　　　　　　　　　　　　　　　
篠原 信雄, 高橋 正幸, 神島 保, 生島 仁史, 大塚 紀幸, 石津 明洋, 丸山 覚, 安部 崇重, 佐澤 陽, 金山 博臣, 野々村 克也, 日本癌治療学会誌, 44, 2, 456, 456, 2009年09月
(一社)日本癌治療学会, 日本語

3.0T MRIを用いた乳房MRI撮像法(Split Dynamic法)の検討
加藤扶美, 尾松徳彦, 小野寺祐也, 神島保, 大山徳子, 寺江聡, 白土博樹, 高橋将人, 細田充主, 高橋弘昌, 水戸寿々子, 石坂欣也, 坂元哲郎, 勝又康友, VAN CAUTEREN Marc, 日本乳癌学会学術総会プログラム・抄録集, 17th, 393, 2009年06月11日
日本語

Efficacy and thyroidal effects of sunitinib in Japanese patients with metastatic renal cell carcinoma: Hypothyroidism and thyroid atrophy as potential biomarkers for sunitinib?
N. Shinohara, M. Takahashi, T. Kamishima, H. Ikushima, A. Sazawa, H. Kanayama, K. Nonomura, JOURNAL OF CLINICAL ONCOLOGY, 27, 15, 2009年05月
英語, 研究発表ペーパー・要旨（国際会議）

動体追跡照射時における肺腫瘍の移動距離と関連因子の検討
小野寺祐也, 西岡典子, 鬼丸力也, 尾松徳彦, 神島保, 加藤扶美, 白土博樹, Radiat Med, 27, Supplement 1, 1, 2009年04月25日
日本語

関節リウマチの超音波による治療効果判定
神島保, ムトウ ナタリアサユリ, 尾松徳彦, 小野寺祐也, 寺江聡, 白土博樹, Radiat Med, 27, Supplement 1, 9, 2009年04月25日
日本語

新開発のsoftwareを用いた肺腫瘍のDT計測値の再現性と妥当性評価
坂本圭太, 神島保, 平田健司, 尾松徳彦, 小野寺祐也, 寺江聡, 玉木長良, 白土博樹, 日本医学放射線学会総会抄録集, 68th, S364-S365, 2009年02月28日
日本語

両手MRIにおける関節リウマチ病変定量のための最適化の試み
神島保, 谷村一秀, 清水昌人, 松橋めぐみ, 深江淳, 近祐次郎, 青木悠子, 尾松徳彦, 寺江聡, 白土博樹, 日本医学放射線学会総会抄録集, 68th, S189, 2009年02月28日
日本語

ダイナミックCTにおける腎体積と大動脈・肝実質増強効果の関係について
神島保, 武藤ナタリア早百合, アーディン ハリス, 尾松徳彦, 小野寺祐也, 寺江聡, 伊藤和夫, 白土博樹, 日本医学放射線学会総会抄録集, 68th, S170, 2009年02月28日
日本語

心臓周囲脂肪分布の評価—体積対面積
大山徳子, 笹木工, 水戸寿々子, 後藤大祐, 古本智夫, 小野寺祐也, 尾松徳彦, 神島保, 寺江聡, 白土博樹, 日独医報, 54, 1, 74, 2009年02月25日
日本語

Intra-articular nodular fasciitis in the elbow joint, with an emphasis on MR imaging findings
Noriko Nishioka, Tamotsu Kamishima, Tatsuya Masuko, Kanako C. Kubota, Miki Komatsu, Norimasa Iwasaki, Takayuki Nojima, Tomoo Itoh, Ardene A. Harris, Akio Minami, Hiroki Shirato, European Journal of Radiology Extra, 69, 2009年01月01日

パワードプラ超音波による関節リウマチ治療効果判定
神島保, 尾松徳彦, 小野寺祐也, 寺江聡, 白土博樹, 日本医学放射線学会総会抄録集, 67th, S180-S181, 2008年02月28日
日本語

心臓周囲脂肪の定量—内臓脂肪の新しい指標
大山徳子, 水戸寿々子, 笹木工, 小野寺祐也, 後藤大祐, 古本智夫, 尾松徳彦, 神島保, 寺江聡, 白土博樹, 日本医学放射線学会総会抄録集, 67th, S318, 2008年02月28日
日本語

新開発のCT volumetryソフトによる生体腎移植ドナーの分腎比の評価
加藤扶美, 神島保, 森田研, 守屋禎之, 野々村克也, 白土博樹, 武藤ナタリア早百合, 小野寺祐也, 胡学斌, 寺江聡, 日本医学放射線学会総会抄録集, 67th, S215, 2008年02月28日
日本語

全身MRIによる骨・軟部腫瘍の画像診断
神島 保, 日本整形外科學會雜誌, 81, 11, 950, 954, 2007年11月25日
日本整形外科学会, 日本語

スポーツ損傷のMRI : 膝関節
神島 保, 加藤 扶美, 白〓 博樹, 臨床スポーツ医学 = The journal of clinical sports medicine, 24, 7, 755, 760, 2007年07月01日
文光堂, 日本語

OP-026 MRIによる前立腺癌の診断 : A prospective study(第95回日本泌尿器科学会総会)
出村 孝義, 日岡 隆矢, 兼田 達夫, 坂井 亙, 長谷川 貴, 西野 茂夫, 神島 保, 後藤田 裕子, 村岡 俊二, 日本泌尿器科學會雜誌, 98, 2, 297, 297, 2007年02月20日
社団法人日本泌尿器科学会, 日本語

造影全身MRIによる関節リウマチの評価　　　　　　　　　　　　　　　
神島 保, 渥美 達也, 堀田 哲也, 酒井 良江, 深江 淳, 保田 晋助, 白土 博樹, 小池 隆夫, 日本医学放射線学会学術集会抄録集, 66回, S367, S367, 2007年02月
(公社)日本医学放射線学会, 日本語

APP-054 MRI-directed template biopsyによる前立腺癌の局在診断(総会賞応募ポスター,第94回日本泌尿器科学会総会)
出村 孝義, 日岡 隆矢, 兼田 達夫, 坂井 亙, 平松 一秀, 長谷川 貴, 西野 茂夫, 神島 保, 後藤田 裕子, 村岡 俊二, 日本泌尿器科學會雜誌, 97, 2, 249, 249, 2006年03月10日
社団法人日本泌尿器科学会, 日本語

関節リウマチに対するインフリキシマブの造影関節エコーによる効果判定
神島 保, 桜井 典之, 渥美 達也, 酒井 良江, 堀田 哲也, 保田 普助, 小池 隆夫, 宮坂 和男, 断層映像研究会雑誌, 33, 1, 17, 17, 2006年03月
断層映像研究会, 日本語

関節リウマチに対するインフリキシマブの造影エコーによる効果判定
増田 香織, 佐藤 恵美, 神島 保, 丹野 麻美, 清水 匡, 宮坂 和男, 超音波検査技術抄録集, 31, 0, 203, 203, 2006年
Japanese Society of Sonographers, 日本語

最近の画像診断法の進歩
神島 保, 丹野 麻美, 笹木 工, 岡 美香, 孫田 恵一, 横山 英辰, 渡辺 良晴, 炭田 修身, 玉木 長良, 宮坂 和男, 日本保険医学会誌, 103, 2, 150, 160, 2005年06月17日
画像診断法はコンピュータの進歩の恩恵を受けて近年急速な進歩を遂げた。それに伴い細分化も進み,今日では放射線医学に携わる者にとっても全体像の把握は必ずしも容易ではない。今回は最近の画像診断法の進歩を主要な画像診断器機ごとに整理して述べる。超音波では造影剤の開発,三次元,四次元画像について,コンピュータ断層撮影法(CT)では脳血流・心臓への応用について,磁気共鳴イメージング(MRI)ではパラレルイメージング,全身MRI,拡散強調画像について,核医学では陽電子放出コンピュータ断層撮影(PET)について,血管造影検査では回転DSA(digital subtraction angiography),血管造影コンピュータ断層撮影法について,技術(ソフト面・ハード面)の進歩,臨床応用につき分かりやすく解説する。また,コンピュータ支援診断(CAD)の現状についても言及する。, 日本保険医学会, 日本語

Liver hemangiomas: Assessment of the change in size using CT and MRI
GA Holland, T Kamishima, DG Mitchell, A Lall, RADIOLOGY, 222, 3, 875, 875, 2002年03月
英語, 研究発表ペーパー・要旨（国際会議）

Computed tomography and magnetic resonance imaging of retroperitoneal and mesenteric tumor
Noriko Oyama, Tamotsu Kamishima, Kouzou Kubo, Daisuke Abo, Toshikazu Nambu, Chihoko Miyazaki, Donald G. Mitchell, Kazuo Miyasaka, Radiologist, 9, 6, 303, 308, 2002年
Lippincott Williams and Wilkins, 英語, 書評論文,書評,文献紹介等

MR imaging and percutaneous therapy of osteitis pubis as a stress injury of sports
T Kamishima, ME Schweitzer, AB Bartolozzi, H Awaya, RADIOLOGY, 221, 117, 117, 2001年11月
英語, 研究発表ペーパー・要旨（国際会議）

CT imaging of chromophobe renal cell carcinoma
N Oyama, T Kamishima, K Kubo, C Miyazaki, Y Ogawa, T Nambu, RADIOLOGY, 221, 125, 125, 2001年11月
英語, 研究発表ペーパー・要旨（国際会議）

MR imaging of the fetus
Tamotsu Kamishima, Taiga Nishihori, Donald G. Mitchell, Toshikazu Nambu, Nobuyuki Fujita, Kazuo Miyasaka, Radiologist, 8, 5, 245, 253, 2001年
Lippincott Williams and Wilkins, 英語, 書評論文,書評,文献紹介等

MR imaging of cysts and cystic lesions of the liver
Tamotsu Kamishima, Taiga Nishihori, Donald G. Mitchell, Toshikazu Nambu, Nobuyuki Fujita, Kazuo Miyasaka, Radiologist, 8, 4, 175, 183, 2001年
Lippincott Williams and Wilkins, 英語, 書評論文,書評,文献紹介等

Small (< 20 mm), early enhancing-nodules without hyperintensity on t2-weighted image in cirrhotic liver: Clinical implication on follow-up MR imaging
Y Jeong, DG Mitchell, T Kamishima, H Kang, RADIOLOGY, 217, 504, 504, 2000年11月
英語, 研究発表ペーパー・要旨（国際会議）

生体部分肝移植術後症例における動静脈同時PTAの試み　　　　　　　　　　　　　　　
神島 保, 立石 宇貴秀, 堀尾 圭司, 市村 亘, 清水 匡, 宮坂 和男, IVR: Interventional Radiology, 14, 4, 507, 507, 1999年10月
(一社)日本インターベンショナルラジオロジー学会, 日本語

腎血管筋脂肪腫に対する腎静脈バルーン閉塞下エタノール動脈塞栓術の試み　　　　　　　　　　　　　　　
立石 宇貴秀, 神島 保, 堀尾 圭司, 市村 亘, 清水 匡, 宮坂 和男, IVR: Interventional Radiology, 14, 4, 508, 508, 1999年10月
(一社)日本インターベンショナルラジオロジー学会, 日本語

肝Nodular Regenerative Hyperplasia(NRH)の画像所見
作原祐介, 藤田信行, 神島保, 毛利学, 岸本理和, 南部敏和, 日独医報, 44, 4, 794-795, 1999年
日本語

Pulmonary vein and left atrial invasion by lung cancer: Assessment with contrast-enhanced three-dimensional MR angiography
K Takahashi, T Kamishima, M Furuse, S Satoh, K Saitoh, T Aburano, RADIOLOGY, 209P, 451, 451, 1998年11月
英語, 研究発表ペーパー・要旨（国際会議）

関節のMRI
上谷, 雅孝, 青木, 隆敏, 神島, 保, 江原, 茂, 杉本, 英治, 福田, 国彦
メディカル・サイエンス・インターナショナル, 2020年12月, 9784815701871, xviii, 682p, 日本語

MR撮像のポジショニングとテクニック : フルカラーCGで学ぶ
杉森, 博行, 神島, 保
メジカルビュー社, 2019年08月, 9784758319348, xii, 234p, 日本語

フルカラーCGで学ぶX線撮影のポジショニングとテクニック
杉森, 博行, 神島, 保
メジカルビュー社, 2018年01月, 9784758319072, xv, 231p, 日本語

関節リウマチの画像診断 : 診断の基本から鑑別診断まで
杉本, 英治, 神島, 保
メディカル・サイエンス・インターナショナル, 2017年09月, 9784895928946, xi, 353p, 日本語

骨軟部画像診断スタンダード = Standards for musculoskeletal imaging
青木, 純, 青木, 隆敏, 上谷, 雅孝, 江原, 茂, 神島, 保, 杉本, 英治, 福田, 国彦, 藤本, 肇
メディカル・サイエンス・インターナショナル, 2014年12月, 9784895927949, xi, 386p, 日本語

骨軟部の超音波診断 : リウマチの早期診断のために
Martino, Fabio, Silvestri, Enzo, Grassi, Walter, Garlaschi, G. (Giacomo), 神島, 保, 佐川, 昭
丸善出版, 2012年06月, 9784621063316, xi, 204p, 日本語

手のリウマチの画像診断
Garlaschi, G. (Giacomo), Silvestri, Enzo, Satragno, Luigi, Cimmino, Marco Amedeo, 佐川, 昭, 神島, 保, シュプリンガージャパン
丸善出版, 2012年06月, 9784621064085, vi, 118p, 日本語

関節リウマチ破壊性変化定量解析システムの妥当性評価
科学研究費助成事業
2021年04月01日 - 2024年03月31日
神島 保, 池田 啓, 渥美 達也, 池辺 将之, 田村 賢一
Genant-modified Sharpスコア（GSS）などの、関節リウマチ（RA）における関節腔狭小化（JSN）のX線スコアリング法は広く受け入れられているが、評価が主観的で煩雑である。そのため、関節裂隙幅（JSW）の変化を自動的に定量化できる部分位相限定相関（PIPOC）を備えたソフトウェアを開発した。本研究の目的は、ソフトウェアを用いてトシリズマブ治療下の関節リウマチ患者のJSN進行を検討することである。
トシリズマブで治療された39名のRA患者（女性35名）を対象とした。中手指節関節および近位指節間関節のＸ線学的進行は、0ヶ月および12ヶ月のGSSに従って評価された。
被験者の均質性を確保するために、ソフトウェア分析のベースラインでGSS = 0の関節をターゲットにした。 JSN進行測定用の社内ソフトウェアの成功率は96.8％（449/464）であった。ソフトウェアで1年間に定量化された手指関節のJSW変化は、GSS進行陽性群の方が陰性群よりも有意に大きかった（p = 0.02）。
PIPOC依存ソフトウェアは、1年間のトシリズマブ治療下の追跡期間中にRA患者のJSN進行を検出できる可能性がある。
日本学術振興会, 基盤研究(C), 北海道大学, 21K07611

関節リウマチ超音波検査：毛細血管ファントムの再現性検討と機種間キャリブレーション
科学研究費助成事業
2012年04月01日 - 2015年03月31日
神島 保, 渥美 達也, 寺江 聡, 西田 睦
関節リウマチ診療において、超音波検査のパワードプラ法を用いることによって関節リウマチの疾患活動性並びに治療効果を推定することができ、超音波検査は重要な役割を担っている。しかしながら、使用する機種によってパワードプラ信号描出能が異なっていることが認識されている。このことは、機種間の標準化における大問題であるが、これに対して真正面から取り組む研究は存在しない。本研究は、そのツールとして毛細血管ファントムの有用性について一貫して検討するとともに、毛細血管ファントムで得られたデータの解析によって得られたデータを臨床に応用し、研究の最終目標である機種の信号校正に肉薄するまでの成果を得ることが出来た。
日本学術振興会, 基盤研究(C), 北海道大学, 24591437

4次元定位放射線治療の基礎
科学研究費助成事業
2005年 - 2009年
白土 博樹, 金子 純一, 西山 修輔, 加藤 千恵次, 青山 英史, 関 興一, 鬼丸 力也, 西岡 健, 森田 浩一, 伊達 広行, 高田 英治, 富岡 智, 工藤 與亮, 小野寺 祐也, 神島 保, 鬼丸 力也, 清水 伸一, 作原 祐介, 大山 徳子, 阿保 大介, 田口 大志
2対のシンチレータBGOと位置検出型光電子増倍管とコリメータにて4次元(時空間)定位を可能とするポジトロン・エミッション位置決め装置FPELを開発し、ポジトロンエミッターの量がある値を超えると0.1mmの精度で5mm直径の45MeV電子線ビームの自動的照射が行われる制御が可能な、4次元定位電子線自動照射実験装置を完成した。同装置にて、ヒトの呼吸運動を擬して周期的に動く小動物を利用し、この小動物に植えた腫瘍に対する45MeV電子線ビームの4次元定位放射線治療を行い、金マーカーなしで、腫瘍近傍のポジトロン・エミッターからの信号だけで、腫瘍を制御することに成功し、4次元定位放射線治療の基礎が整った。
日本学術振興会, 特定領域研究, 北海道大学, 17016002

相互作用放射線治療
科学研究費助成事業
2006年 - 2008年
白土 博樹, 本間 さと, 玉木 長良, 久下 裕司, 伊達 広行, 鬼柳 善明, 畠山 昌則, 金子 純一, 水田 正弘, 犬伏 正幸, 但野 茂, 田村 守, 早川 和重, 松永 尚文, 石川 正純, 青山 英史, 作原 祐介, 鬼丸 力也, 阿保 大介, 笈田 将皇, 神島 保, 寺江 聡, 工藤 與亮, 小野寺 祐也, 尾松 徳彦, 清水 伸一, 西村 孝司, 鈴木 隆介, ジェラード ベングア
いままでの先端放射線医療に欠けていた医療機器と患者のinteractionを取り入れた放射線治療を可能にする。臓器の動き・腫瘍の照射による縮小・免疫反応などは、線量と時間に関して非線形であり、システムとしての癌・臓器の反応という概念を加えることが必要であることが示唆された。生体の相互作用を追求していく過程で、動体追跡技術は先端医療のみならず、基礎生命科学でも重要な役割を果たすことがわかった。
日本学術振興会, 基盤研究(A), 北海道大学, 18209039