2017年, Japan Surgical Society (JSS), The 117th Annual Congress of Japan Surgical Society (JSS) traveler’s grant　　　　　　　　　　　　　　　

2017年, Canadian Cancer Society Travel Awards　　　　　　　　　　　　　　　

2016年, The Joseph M. West Family Memorial Fund　　　　　　　　　　　　　　　

2015年, University Health Network, Office of Research Trainees (ORT) conference travel award　　　　　　　　　　　　　　　

2014年, Best of World conference on Lung Cancer 2014　　　　　　　　　　　　　　　

2013年, Saitama cancer center research scholarship 2013 - 2014　　　　　　　　　　　　　　　

2011年, Chiba university scholarship post-graduate student 2011 - 2015　　　　　　　　　　　　　　　

Developing novel non-assistant help operation in dual-portal robotic-assisted thoracic surgery (neoDRATS)
Hideki Ujiie, Hiroki Ebana, Jun Suzuki, Masato Chiba, Hikaru Watanabe, Aki Kobayashi, Satoshi Shiono, Yasuhiro Tsutani, Tatsuya Kato
JTCVS Techniques, 27, 146, 150, 2024年08月, ［査読有り］, ［筆頭著者, 責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）, Objective: To introduce and evaluate the non-assistant help operation in dual-portal robotic-assisted thoracic surgery (neoDRATS), a novel technique designed to eliminate the need for skilled assistants by using all 4 robotic arms independently during anatomical lung surgery. Methods: Patients were placed in the lateral decubitus position under general anesthesia with single-lung ventilation. The da Vinci Xi Surgical System was used, with specific configurations for right- and left-side operations. The neoDRATS technique used a 4-cm working port and a 1.8-cm secondary port, with detailed guidelines for optimal setup and robotic arm manipulation. Results: The neoDRATS approach demonstrated successful surgical outcomes without the need for a skilled assistant. The use of a 0° camera and careful placement of instruments minimized interference within the thoracic cavity. The technique provided smooth operability and minimized postoperative discomfort. Video demonstrations of right and left upper lobectomies are provided to illustrate the approach. Conclusions: NeoDRATS offers a practical, safe, and minimally invasive alternative to conventional multiportal and uniportal robotic-assisted thoracic surgeries. This technique simplifies the surgical process, particularly in settings with limited availability of skilled assistants, and represents a significant advancement in robotic thoracic surgery. Further refinement and clinical integration of neoDRATS are anticipated as robotic innovations continue to evolve.

Epithelioid pleural mesothelioma successfully treated with perioperative immunotherapy: a case report.
Gaku Yamazaki, Aki Fujiwara-Kuroda, Jun Muto, Hideki Ujiie, Masato Aragaki, Megumi Furuta, Sakurako Ohno, Kanako C Hatanaka, Yutaka Hatanaka, Yoshihiro Matsuno, Tatsuya Kato
General Thoracic and Cardiovascular Surgery Cases, 3, 1, 31, 31, 2024年06月11日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Pleural mesothelioma, characterized by a dismal prognosis even with multimodal therapy, has seen emerging interest in immune checkpoint inhibitors (ICIs) due to their demonstrated efficacy. Here, we present a case of epithelioid-type pleural mesothelioma with chest wall invasion treated with definitive ICI therapy, resulting in a remarkable pretreatment effect. CASE PRESENTATION: A 46-year-old man was diagnosed with an abnormal chest shadow on a medical check, and a computed tomography scan showed pleural thickening at the dorsal right upper chest wall. One of the nodules was suspected to have invaded the chest wall. A needle biopsy revealed epithelioid-type pleural mesothelioma. After five cycles of nivolumab plus ipilimumab, he underwent right pleurectomy/decortication (P/D). Pathological examination revealed a significant treatment effect, showing numerous lymphocytes infiltrating the tumor nodule and viable tumor cells localized at approximately 6 mm. CONCLUSION: Although further accumulation of cases is required to evaluate the effectiveness and case selection, P/D after immunotherapy is a useful curative treatment option for advanced pleural mesothelioma.

Impact of pulmonary vein-first ligation during lobectomy on the postoperative survival and recurrence rates in patients with non-small cell lung cancer: a multicenter propensity score-matched study.
Haruhiko Shiiya, Hideki Ujiie, Ryohei Chiba, Shunsuke Nomura, Kazuto Ohtaka, Aki Fujiwara-Kuroda, Masato Aragaki, Keita Takahashi, Kazufumi Okada, Tatsuya Kato
Surgery today, 54, 11, 1369, 1378, 2024年05月30日, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）, PURPOSE: Surgical manipulation of the lungs increases the number of circulating tumor cells and the subsequent risk of metastasis in patients with lung cancer. This study investigated whether or not ligating the tumor-draining pulmonary vein first during lobectomy could improve the prognosis of these patients. METHODS: We retrospectively evaluated patients who underwent curative lobectomy for solitary nonsmall-cell lung carcinoma between January 2012 and December 2016. We divided the patients into the vein-first group, in which all associated pulmonary veins were dissected and severed before cutting the pulmonary artery, bronchus, or pulmonary fissure, and the other procedure group. RESULTS: Overall, we included 177 and 413 patients in the vein-first and other procedure groups, respectively. Propensity score matching yielded 67 pairs of patients. The 5-year overall survival (85.6% [95% confidence interval, 77.3-94.8%] vs. 69.4% [58.7-81.9%], P = 0.03%) and recurrence-free survival (73.4% [63.3-85.1%] vs. 53.5% [42.5-67.3%], P = 0.02) were significantly better in the vein-first group than in the other procedure group. The cumulative recurrence rate at 5 years post-surgery was significantly lower in the vein-first group than in the other procedure group (21.7% vs. 38.3%, P = 0.04). CONCLUSION: Our study suggests that ligating the pulmonary vein first during lobectomy for lung cancer can improve the overall survival, recurrence-free survival, and cumulative recurrence rate.

Dose Optimization of Intravenous Indocyanine Green for Malignant Lung Tumor Localization
Hideki Ujiie, MD, PhD, Ryohei Chiba, Akihiro Sasaki, Shunsuke Nomura, Haruhiko Shiiya, Shohei Otsuka, Hiroshi Yamasaki, Aki Fujiwara-Kuroda, Kazuto Ohtaka, Masato Aragaki, Kazufumi Okada, Yuma Ebihara, Tatsuya Kato
Journal of Clinical Medicine, 13, 10, 2024年05月10日, ［査読有り］, ［筆頭著者, 責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: Intravenously administered indocyanine green (ICG) accumulates in lung tumors, facilitating their detection via a fluorescence spectrum measurement. This method aids in identifying tumor locations that are invisible to the naked eye. We aim to determine the optimal ICG dose and administration method for accurate tumor identification during lung resection surgeries, utilizing a novel ICG fluorescence spectroscopy system for precise tumor localization. Materials and Methods: ICG should be dissolved in the provided solution or distilled water and administered intravenously approximately 24 h before surgery, beginning with an initial dose of 0.5 mg/kg. If the tumor detection rate is insufficient, the dose may be gradually increased to a maximum of 5.0 mg/kg to determine the optimal dosage for effective tumor detection. This fluorescence spectroscopy during surgery may reveal additional lesions that remain undetected in preoperative assessments. The primary endpoint includes the correct diagnostic rate of tumor localization. The secondary endpoints include the measurement of the intraoperative ICG fluorescence spectral intensity in lung tumors, the assessment of the operability and safety of intraperitoneal ICG administrations, the measurement of the ICG fluorescence spectral intensity in surgical specimens, the comparison of the spectral intensity in lung tissues during collapse and expansion, the correlation between ICG camera images and fluorescence spectral intensity, and the comparison of fluorescence analysis results with histopathological findings. The trial has been registered in the jRCT Clinical Trials Registry under the code jRCTs011230037. Results and Conclusions: This trial aims to establish an effective methodology for localizing and diagnosing malignant lung tumors, thereby potentially improving surgical outcomes and refining treatment protocols.

Acute onset of constrictive pericarditis due to acute myelomonocytic leukemia: A case and literature review.
Naoki Kosaka, Takanori Uchiyama, Masahiro Onozawa, Jun Nagai, Jiro Koya, Suguru Ishizaka, Toshiyuki Nagai, Yohei Ikebe, Kenjiro Kato, Zen-Ichi Tanei, Jun Sakakibara-Konishi, Yuta Hasegawa, Hiroyuki Ohigashi, Hideki Goto, Daigo Hashimoto, Hideki Ujiie, Satoshi Hirano, Satoshi Konno, Toshihisa Anzai, Koji Taniguchi, Shinya Tanaka, Takanori Teshima
Internal medicine (Tokyo, Japan), 2024年04月16日, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）, We herein present a fatal case of constrictive pericarditis (CP) due to acute myelomonocytic leukemia (AMML) in a patient who initially complained of an acute onset of chest pain two days after COVID-19 vaccination. An autopsy revealed pericardial infiltration of leukemic cells. CP is rarely associated with leukemia and only 14 cases have been reported in the literature. The etiology of CP in previous reports included leukemic infiltration, graft-versus-host disease, drug-induced, post-radiation, autoimmune, and otherwise unidentified. This case indicates that leukemic infiltration can cause CP and that clinicians should include leukemia in the differential diagnosis of CP.

A simple and safe surgical technique for nonpalpable lung tumors: One-stop Solution for a nonpalpable lung tumor, Marking, Resection, and Confirmation of the surgical margin in a Hybrid operating room (OS-MRCH).
Aki Fujiwara-Kuroda, Masato Aragaki, Yasuhiro Hida, Hideki Ujiie, Kazuto Ohtaka, Haruhiko Shiiya, Kichizo Kaga, Tatsuya Kato
Translational lung cancer research, 13, 3, 603, 611, 2024年03月29日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, When performing thoracoscopic partial resections of nonpalpable lung tumors such as ground-glass opacities (GGOs) and small tumors, detecting the location of the lesion and assessing the resection margins can be challenging. We have developed a novel method to ease this difficulty, the One-stop Solution for a nonpalpable lung tumor, Marking, Resection, and Confirmation of the surgical margin in a Hybrid operating room (OS-MRCH), which uses a hybrid operating room wherein the operating table is seamlessly integrated with cone-beam computed tomography (CBCT). We performed the OS-MRCH method on 62 nodules including primary lung cancer presenting with GGO. Identification of the lesion and confirmation of the margin were performed in 58 of the cases, while nodules were detected in all. The frequency of computed tomography (CT) scans performed prior to resection was one time in 51 cases, two times in eight cases, and ≥3 times in three cases. Additional resection was performed in two cases. The median operative time was 85.0 minutes, and the median pathological margin was 11.0 mm. The key advantages of this method are that all surgical processes can be completed in a single session, specialized skill sets are not required, and it is feasible to perform in any facility equipped with a hybrid operating room. To overcome its disadvantages, such as longer operating time and limited patient positioning, we devised various methods for positioning patients and for CT imaging of the resected specimens. OS-MRCH is a simple, useful, and practical method for performing thoracoscopic partial resection of nonpalpable lung tumors.

Developing a Virtual Reality Simulation System for Preoperative Planning of Robotic-Assisted Thoracic Surgery
Hideki Ujiie, MD, PhD, Ryohei Chiba, Aogu Yamaguchi, Shunsuke Nomura, Haruhiko Shiiya, Aki Fujiwara-Kuroda, Kichizo Kaga, Chad Eitel, Tod Clapp, Tatsuya Kato
Journal of Clinical Medicine, 13, 2, 2024年01月21日, ［査読有り］, ［筆頭著者, 責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）, Background. Robotic-assisted thoracic surgery (RATS) is now standard for lung cancer treatment, offering advantages over traditional methods. However, RATS's minimally invasive approach poses challenges like limited visibility and tactile feedback, affecting surgeons' navigation through com-plex anatomy. To enhance preoperative familiarization with patient-specific anatomy, we devel-oped a virtual reality (VR) surgical navigation system. Using head-mounted displays (HMDs), this system provides a comprehensive, interactive view of the patient's anatomy pre-surgery, aiming to improve preoperative simulation and intraoperative navigation. Methods. We integrated 3D data from preoperative CT scans into Perspectus VR Education software, displayed via HMDs for in-teractive 3D reconstruction of pulmonary structures. This detailed visualization aids in tailored preoperative resection simulations. During RATS, surgeons access these 3D images through Tile-ProTM multi-display for real-time guidance. Results. The VR system enabled precise visualization of pulmonary structures and lesion relations, enhancing surgical safety and accuracy. The HMDs offered true 3D interaction with patient data, facilitating surgical planning. Conclusions. VR sim-ulation with HMDs, akin to a robotic 3D viewer, offers a novel approach to developing robotic surgical skills. Integrated with routine imaging, it improves preoperative planning, safety, and accuracy of anatomical resections. This technology particularly aids in lesion identification in RATS, optimizing surgical outcomes.

Preclinical analysis of the efficacy of near-infrared photoimmunotherapy and anti-PD-1 antibody combination therapy for treating CD73-positive lung cancer
Hideki Ujiie, MD, PhD
Journal of Clinical Oncology, 2024年
研究論文（学術雑誌）

Uniportal robotic-assisted thoracic surgery for mediastinal tumor resection via the lateral intercostal approach: a surgical technique and our ingenuity
Watanabe, H., Ebana, H., Suzuki, J., Ujiie, H., Ichiba, H., Hoshijima, K., Kobayashi, A., Shiono, S.
Journal of Visualized Surgery, 10, 2024年, ［査読有り］
研究論文（学術雑誌）, Robotic-assisted thoracic surgery (RATS) has gained increasing interest in the last few years and is becoming more widely adopted worldwide thanks to significant technical advantages such as stereoscopic visualization, accurate and complex movements, camera stability, and a shorter learning curve compared to video-assisted thoracoscopic surgery (VATS). However, because robotic platforms are designed for four robotic arms, four to five incisions have been considered necessary for most thoracic approaches, which contrasts with the concept of minimal invasiveness. The blending of the uniportal approach with robotic technology would bring enormous improvements in safety, effective and postoperative recovery. Recently, uniportal RATS (URATS) approaches have been reported in the pursuit of minimally invasive procedures. However, specific skills are needed to perform URATS. Although there are increasing reports of URATS using the da Vinci single-port (SP) robot system for mediastinal tumor resection, there have been only a few reports detailing the surgical technique of URATS using the da Vinci Xi system. The da Vinci SP platform is too wide to use an approach via the intercostal space because of the 2.5 cm cannula. In the other hand, the da Vinci Xi platform is suitable to use an approach via the intercostal space because of the 8 mm cannula. Herein, we report the surgical technique of URATS using the da Vinci Xi system with innovative port placement. This surgical technique causes less intercostal invasive injury and is suitable for mediastinal tumor resection in hospitals that do not already have a da Vinci SP system. Our experience and literature suggest that URATS for mediastinal tumor procedures is safe and effective and should be considered as a valid additional surgical option.

体腔鏡手術の教え方・学び方 5.呼吸器 2)Virtual reality技術を活用した呼吸器外科ロボットトレーニング法
氏家秀樹
外科, 86, 3, 278, 282, 南江堂, 2024年, ［査読有り］, ［筆頭著者, 責任著者］
日本語, ＜文献概要＞呼吸器外科ロボット手術における視覚と操作の制限を克服するため,virtual reality(VR)技術を活用した場合の有用性を評価した.術前のCTデータを用いて3Dイメージを作成し,head mount display(HMD)を装着してVR空間での観察を行うことと実際の手術操作の感覚を組み合わせることの有効性が示された.このシステムは実際の手術前のトレーニングにも有用であると考える.

Dual-portal robotic-assisted thoracic surgery (DRATS) as a reduced port RATS: early experiences in three institutions in Japan
Hikaru Watanabe, Hiroki Ebana, Naoki Kanauchi, Jun Suzuki, Hideki Ujiie, Masato Chiba, Kaito Sato, Soumei Matsuo, Kazumasa Hoshijima, Aki Kobayashi, Satoshi Shiono
Journal of Thoracic Disease, 15, 12, 6475, 6482, 2023年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: Robotic-assisted thoracic surgery (RATS) has gained increasing interest in recent years, with most procedures performed using the conventional multiportal approach. Uniportal RATS (URATS) approaches have recently been reported in the pursuit of minimally invasive procedures. However, URATS requires specific skills. Herein, we introduce dual-portal RATS (DRATS) performed with two incisions. Methods: Data of DRATS procedures performed from December 2022 to May 2023 were retrospectively reviewed. Twenty patients with lung cancer underwent anatomical lung resections via DRATS performed by our group at three institutes. Results: Among 20 cases of planned DRATS for anatomical pulmonary resections, there were no conversions to thoracotomy and no need for extra ports. The mean surgery time was 121±60 minutes and mean console time was 91±47 minutes. The mean intraoperative blood loss volume was 9.6±12.1 g. The mean duration of chest tube drainage and hospital stay were 2±1 and 5±2 days, respectively. The mean numerical rating scale for pain was 2±1 on the first postoperative day, 1±1 on the third day, and 1±1 at discharge. There were no postoperative complications or mortalities. Conclusions: Our primary experience shows that DRATS is safe and feasible for anatomical lung resection. We consider DRATS to be a very good preliminary step in the future transition to URATS.

Tumor-to-thoracic height ratio as an easy method to predict the feasibility of reduced-port video-assisted thoracic surgery for mediastinal lesions in children: a single-center experience.
Haruhiko Shiiya, Kichizo Kaga, Hideki Ujiie, Aki Fujiwara-Kuroda, Jun Muto, Shunsuke Nomura, Shohei Honda, Tatsuya Kato
Journal of thoracic disease, 15, 9, 5020, 5028, 2023年09月28日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, In the last few decades, reduced-port video-assisted thoracic surgery (RP-VATS) has been developed to minimize surgical invasiveness. Nevertheless, VATS in children can occasionally be difficult because the lesion occupies a small thoracic cavity, limiting the working space. This study aimed to assess the feasibility of RP-VATS for the resection of mediastinal lesions in children in association with the tumor-to-thoracic height ratio (TTH ratio). We reviewed all patients aged ≤10 years who underwent resection for mediastinal lesions in our institute between January 2008 and August 2022. Patients who underwent diagnostic procedures were excluded from this study. The TTH ratio was calculated as tumor height divided by thoracic height. Seven patients in the RP-VATS group and six in the conventional procedures (multi-portal VATS or open surgery) group were included in this study. The TTH ratio was significantly lower in the RP-VATS group than in the conventional procedures group (median, 26.3% vs. 50.8%; P=0.007). The operating time (P=0.01) and duration of drainage (P=0.003) were significantly shorter and the blood loss (P=0.001) was significantly lower in the RP-VATS group than in the conventional procedures group. After adjusting for age, a lower TTH ratio was significantly associated with the completion of RP-VATS (odds ratio: 0.776; 95% confidence interval: 0.529-0.926; P=0.048). In conclusion, RP-VATS can be performed appropriately in carefully selected cases of pediatric mediastinal lesions. A low TTH ratio may predict the feasibility of RP-VATS. Further studies are warranted to determine the criteria for the indications of RP-VATS in children, so that more children can benefit from RP-VATS.

High density and proximity of CD8+ T cells to tumor cells are correlated with better response to nivolumab treatment in metastatic pleural mesothelioma.
Yuting Yin, Rie Sakakibara, Takayuki Honda, Susumu Kirimura, Pissacha Daroonpan, Masashi Kobayashi, Kohei Ando, Hideki Ujiie, Tatsuya Kato, Kichizo Kaga, Takahiro Mitsumura, Ryoji Nakano, Hiroyuki Sakashita, Shinichi Matsuge, Hironori Ishibashi, Takumi Akashi, Yasuhiro Hida, Takao Morohoshi, Miyuki Azuma, Kenichi Okubo, Yasunari Miyazaki
Thoracic cancer, 14, 20, 1991, 2000, WILEY, 2023年05月30日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: The efficacy of immune checkpoint inhibitors (ICIs) in pleural mesothelioma has recently been established. The response to ICIs can be predicted by quantitative analysis of cells and their spatial distribution in the tumor microenvironment (TME). However, the detailed composition of the TME in pleural mesothelioma has not been reported. We evaluated the association between the TME and response to ICIs in this cancer. METHODS: A retrospective analysis of 22 pleural mesothelioma patients treated with nivolumab in different centers was performed using surgical specimens. Four patients had a partial response to nivolumab (response group) and 18 patients had stable or progressive disease (nonresponse group). The number of CD4, CD8, FoxP3, CK, and PD-L1 positive cells, cell density, and cell-to-cell distance were analyzed by multiplex immunofluorescence. RESULTS: PD-L1 expression did not differ significantly between the response and nonresponse groups. The density of total T cells and of CD8+ T cells was significantly higher in the response than in the nonresponse group. CD8+ T cells were more clustered and located closer to tumor cells, whereas regulatory T cells were located further from tumor cells in the response than in the nonresponse group. CONCLUSIONS: High density and spatial proximity of CD8+ T cells to tumor cells were associated with better response to nivolumab, whereas the proximity of regulatory T cells to tumor cells was associated with worse response, suggesting that the distinct landscape of the TME could be a potential predictor of ICI efficacy in pleural mesothelioma.

A novel edge-marking method in pleural covering with video-assisted thoracic surgery.
Aki Fujiwara-Kuroda, Yasuhiro Hida, Hideki Ujiie, Kichizo Kaga, Tatsuya Kato
Interdisciplinary cardiovascular and thoracic surgery, 36, 3, 2023年03月02日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Total pleural covering is implemented to reinforce the visceral pleura with surgical sheets. It has been adopted for diffuse cystic lung diseases such as lymphangioleiomyomatosis to prevent pneumothorax and has achieved good results. The procedure is technically demanding, because it is difficult to cover the entire visceral pleura without disarrangement and jamming of surgical sheets, especially during thoracoscopic surgery, where grasping of a wrong site might happen when unfolding the sheets. Herein, we report a technique to cover the entire pleura with dotted line folded sheets to ease the thoracoscopic procedure. We found that the use of this marking method made the procedure easier, with just a little ingenuity, because marking the edges of sheets with dashed lines clarifies the site that should be grasped, thus preventing the incidence of grasping the wrong part of the sheet. Pleural covering with dotted line folded surgical sheets is a useful method for reduced port thoracoscopic surgery.

Distribution and clinical impact of molecular subtypes with dark zone signature of DLBCL in a Japanese real-world study
Hideki Ujiie, MD, PhD
Blood Advances, 2023年
研究論文（学術雑誌）

Single Cell Multi Omics and Spatial Analysis Reveals Plasmablast Signature Malignant Cells As a Key of Intratumor Heterogeneity in Primary Central Nervous System Lymphoma
Hideki Ujiie, MD, PhD
Blood, 2023年
研究論文（学術雑誌）

CD79 Expression Is Associated with Cell-of-Origin and Outcome in Diffuse Large B-Cell Lymphoma
Hideki Ujiie, MD, PhD
Blood, 2023年
研究論文（学術雑誌）

Fatal case of subdural empyema caused by Campylobacter rectus and Slackia exigua
Yuki Munekata, Saki Yamamoto, Shun Kato, Yutaro Kitagawa, Ken Enda, Nanase Okazaki, Satoshi Tanikawa, Zen Ichi Tanei, Yohei Ikebe, Takahiro Osawa, Soichiro Takamiya, Hideki Ujiie, Masahiro Onozawa, Satoshi Hirano, Miki Fujimura, Shinya Tanaka
Autopsy and Case Reports, 13, e2023433, 2023年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, We report a fatal subdural empyema caused by Campylobacter rectus in a 66-year-old female who developed acute onset of confusion, dysarthria, and paresis in her left extremities. A CT scan showed hypodensity in a crescentic formation with a mild mid-line shift. She had a bruise on her forehead caused by a fall several days before admission, which initially raised subdural hematoma (SDH) diagnosis, and a burr hole procedure was planned. However, her condition deteriorated on the admission night, and she died before dawn. An autopsy revealed that she had subdural empyema (SDE) caused by Campylobacter rectus and Slackia exigua. Both microorganisms are oral microorganisms that rarely cause extra-oral infection. In our case, head trauma caused a skull bone fracture, and sinus infection might have expanded to the subdural space causing SDE. CT/MRI findings were not typical for either SDH or SDE. Early recognition of subdural empyema and prompt initiation of treatment with antibiotics and surgical drainage is essential for cases of SDE. We present our case and a review of four reported cases.

Parietal pleural small holes found in patients with primary spontaneous pneumothorax associated with relatively mild chest wall flatness: a retrospective study.
Haruhiko Shiiya, Akihiko Tanaka, Motoki Sakuraba, Hideki Ujiie, Tatsuya Kato
Journal of thoracic disease, 14, 9, 3255, 3264, 2022年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: During surgery for spontaneous pneumothorax, parietal pleural small holes (PPSHs) are occasionally found around the apex of the intrapleural space; however, this has not been well recognized. Additionally, chest wall flatness is usually observed in patients with primary spontaneous pneumothorax (PSP) and PPSHs. This study aimed to investigate the prevalence of PPSH and evaluate the characteristics of patients with PPSH. We also investigated the degree of chest wall flatness in patients with PPSHs. METHODS: We retrospectively reviewed all patients who underwent thoracoscopic surgery for pneumothorax at our department between April 2014 and May 2021. A propensity-matched analysis was used to compare the characteristics of patients with and without PPSH. RESULTS: A total of 490 patients were enrolled in this study. PPSH was found in 45 of 297 (15.2%) patients with PSP and one of 193 (0.5%) patients with secondary pneumothorax. PSP was independently associated with the presence of PPSH after adjusting for age and sex [primary/secondary, odds ratio (OR) =34.3, 95% confidence interval (CI): 4.7-250.9; P<0.001]. Among patients with PSP, the flatness of the chest wall in patients with PPSH was not as severe as that in patients without PPSH {thoracic anteroposterior diameter (APDT) to transverse diameter (TDT) ratio; with PPSH: median =0.517 [interquartile range (IQR) =0.480-0.554] vs. without PPSH: median =0.487 (IQR =0.463-0.529; P=0.031)} after propensity score matching. CONCLUSIONS: PPSH is found in a non-negligible proportion of patients with PSP, and patients with PPSHs show a relatively mild flat chest among patients with PSP. Clinicians should be aware of PPSH, and further understanding of this condition may contribute to a better understanding of PSP.

A case report of video-assisted flap bronchoplasty for central type typical carcinoid
Yuya Wada, Hideki Ujiie, Ryohei Chiba, Shunsuke Nomura, Aki Fujiwara-Kuroda, Kichizo Kaga, Satoru Wakasa, Tatsuya Kato
VIDEO-ASSISTED THORACIC SURGERY, 7, AME PUBLISHING COMPANY, 2022年08月, ［査読有り］, ［責任著者］
英語, 研究論文（学術雑誌）, Background: The use of complete video-assisted thoracoscopic surgery (c-VATS) for primary bronchial tumors has increased due to its less invasive nature and cosmetic advantages. However, no studies have reported about flap bronchoplasty using c-VATS due to its technicality. Case Description: A woman in her 20s presented with dyspnea and chest tightness. Computed tomography (CT) showed a 15x18-mm-sized mass located from the left second carina to the lower lobe bronchus root. Flap bronchoplasty using c-VATS was performed. The tumor developed from the second carina near the anterior wall of the left main bronchial cartilage. The upper lobe bronchial root was resected while ensuring surgical margin. The B6 bronchial wall was trimmed to create a flap, and bronchoplasty was performed to fill the defect. After bronchoplasty, the fifth intercostal muscle valve was wrapped around the flap. Postoperative course was uneventful, and bronchoscopy revealed no stenosis. There has been no adverse events and recurrence for 2 years after surgery. Conclusions: Flap bronchoplasty from the resected area allowed preservation of the basal area, and was a useful technique in terms of function preservation. Since the patient in this case was a young female, a full thoracoscopic surgery was completed successfully in consideration of invasion and appearance.

Anatomical segmentectomy under uniportal video-assisted thoracoscopic surgery for early staged non-small cell lung cancer: a case report
Guan Wang, Zhanwu Yu, Jijia Li, Wei Chen, Tianyi Ji, Hideki Ujiie, Motoki Yano, Hongxu Liu
JOURNAL OF THORACIC DISEASE, 14, 9, 3613, 3623, AME PUBLISHING COMPANY, 2022年08月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: Anatomical segmentectomy has become more and more universal in thoracic surgery because of the increasing detection of pulmonary nodules with ground-glass opacity (GGO), most of which proved early staged non-small cell lung cancer (NSCLC) postoperative. With the advantage of preservation of normal lung tissues, segmentectomy may be performed by surgeons when computed tomography (CT) scan shows pure GGO or multiple GGOs appearing. Especially when the patients with poor cardiopulmonary function or severe comorbidities or in the circumstance of bilateral pulmonary GGOs, segmentectomy can provide opportunities to radically resect all lesions. With the development of minimally invasive surgery technology, uniportal video-assisted thoracoscopic surgery (VATS) has become the regular operative route in many medical centers because it can provide less access trauma, less stress response, less pain, shorter hospital stays, and a lower postoperative complication rate and corresponds well with the idea of "minimally invasive ". However, all of the procedures must be performed in one tiny portal, so uniportal VATS anatomical segmentectomy not only needs the skill and patience of surgeons but the effective cooperation of assistants, nurses and anesthetists, and plenty of details must be paid special attention. Case Description: Here we present a video of a patient undergoing S1 segmentectomy of right upper lobectomy (RUL) under uniportal VATS. The chief complaints of the patients was that two pure GGOs in the bilateral upper lobe were found by physical examination for 26 months and he had no symptoms. We performed S1 segmentectomy of RUL under uniportal first time and performed trisegmentectomy of left upper lobectomy (LUL) 3 months later. With routinely follow-up, no evidence of relapse and metastasis disease was found. Conclusions: We think anatomical segmentectomy under uniportal VATS can be a feasible and safe procedure that reduces trauma and has equivalent oncology outcomes to lobectomy in early-stage lung cancer but need a more experienced medical center to perform.

A novel system for analyzing indocyanine green (ICG) fluorescence spectra enables deeper lung tumor localization during thoracoscopic surgery.
Ryohei Chiba, Yuma Ebihara, Haruhiko Shiiya, Hideki Ujiie, Aki Fujiwara-Kuroda, Kichizo Kaga, Liming Li, Satoru Wakasa, Satoshi Hirano, Tatsuya Kato
Journal of thoracic disease, 14, 8, 2943, 2952, 2022年08月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: Palpation of tumors during thoracoscopic surgery remains difficult, and identification of deep-seated tumors may be impossible. This preclinical study investigated the usefulness of a novel indocyanine green (ICG) fluorescence spectroscopy system for tumor localization. Methods: ICG was diluted to 5.0×10-2 mg/mL in fetal bovine serum (FBS) and mixed with silicone resin to prepare pseudo-tumors. Sponges of different densities and a porcine lung were placed on top of the pseudo-tumors, which were examined using a novel fluorescence spectroscopy system and a near-infrared (NIR) camera. Spectra were measured for different sponge and lung thicknesses, and the lung spectra were measured during both inflation and deflation. Results: The fluorescence spectroscopy system was able to identify tumors at depths ≥15 mm, while the NIR system was not. The spectroscopy system also detected tumors at greater depths when the density of the intervening material was lower. Depending on the density and thickness of the intervening material, the system could detect spectra as deep as 40 mm for sponges and 30 mm for lungs. Conclusions: This new fluorescence spectroscopy system can be used to identify lung tumors up to a depth of 30 mm in experiments using pseudo-tumors and a porcine lung, which may aid in tumor identification during thoracoscopic surgery.

Preclinical evaluation of thin convex probe endobronchial ultrasound-guided transbronchial needle aspiration for intrapulmonary lesions.
Tsukasa Ishiwata, Terunaga Inage, Alexander Gregor, Yamato Motooka, Harley H L Chan, Nicholas Bernards, Masato Aragaki, Zhenchian Chen, Hideki Ujiie, Tomonari Kinoshita, Andrew Effat, Kazuhiro Yasufuku
Translational lung cancer research, 11, 7, 1292, 1301, 2022年07月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: Conventional flexible bronchoscopy has not achieved the high diagnostic yield for intrapulmonary lesions as seen with image-guided transthoracic biopsy. A thin convex probe endobronchial ultrasound bronchoscope (TCP-EBUS) with a 5.9-mm tip was designed to improve peripheral access over conventional EBUS bronchoscopes to facilitate real-time sampling of intrapulmonary lesions under ultrasound guidance. Methods: TCP-EBUS was inserted into the distal airways of ex-vivo human lungs to assess bronchial accessibility relative to clinically available bronchoscopes. The short- (≤1 h) and medium-term (≤10 d) safety of TCP-EBUS insertion and EBUS-guided transbronchial needle aspiration (TBNA) using a 25-gauge needle were evaluated physiologically and radiologically in live pigs. TCP-EBUS-guided TBNA feasibility was assessed in-vivo with pig intrapulmonary pseudo-tumors and ex-vivo with resected human lung cancer specimens. Results: For bronchial accessibility, TCP-EBUS demonstrated greater reach than the 6.6-mm convex probe endobronchial ultrasound (CP-EBUS) in all bronchi, as well as surpassed a 5.5-mm conventional bronchoscope in 63% (131/209) and a 4.8-mm conventional bronchoscope in 27% (57/209) of assessed bronchi. The median bronchial generation and the mean diameter of bronchi TCP-EBUS reached was 4 (range, 3-7) and 3.3±0.7 mm, respectively. No major complications related to TCP-EBUS-guided TBNA in distal airways were observed in the live pigs. Scattered mucosal erythema of the bronchial walls was observed immediately after TCP-EBUS insertion; this self-resolved by day 10. TCP-EBUS could successfully reach and visualize intrapulmonary targets via ultrasound, with no difficulty in needle deployment or sampling. Conclusions: TCP-EBUS has the potential to facilitate safe real-time transbronchial sampling of intrapulmonary lesions in the central and middle lung fields.

Partitioning the lung field based on the depth ratio in three-dimensional space.
Jingjing Huang, Chengyu Bian, Wenhao Zhang, Guang Mu, Zhipeng Chen, Yang Xia, Mei Yuan, Hideki Ujiie, Jean H T Daemen, Erik R de Loos, Quan Zhu, Weibing Wu, Liang Chen, Jun Wang
Translational lung cancer research, 11, 6, 1165, 1175, 2022年06月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: To explore the feasibility of the depth ratio method partitioning the lung parenchyma and the depth distribution of lung nodules in pulmonary segmentectomy. Methods: Based on the measurement units, patients were allocated to the chest group, the lobar group, and the symmetrical 3 sectors group. In each unit, the center of the respective bronchial cross-section was set as the starting point (O). Connecting the O point with the center of the lesion (A) and extending to the endpoint (B) on the pleural, the radial line (OB) was trisected to divide the outer, middle, and inner regions. The depth ratio and relevant regional distribution were simultaneously verified using 2-dimensional (2D) coronal, sagittal, and axial computed tomography images and 3-dimensional (3D) reconstruction images. Results: Two hundred and nine patients were included in this study. The median age was 53 (IQR, 44.5-62) years and 64 were males. The intra-group consistency of the depth ratio region partition was 100%. The consistency of the inter-group region partition differed among the three groups (Kappa values 0.511, 0.517, and 0.923). The chest group, lobar group, and symmetrical 3 sectors group had 69.4%, 26.3%, and 4.8% mediastinum disturbance, respectively (P<0.001). Conclusions: The depth ratio method in the symmetrical 3 sectors of the lung maximally eliminated the disturbance of the mediastinal structures and more accurately trisected the lung parenchymal in 3D space. Sublobar resection based on subsegments strategy is feasible for outer 2/3 pulmonary nodules when depth ratio is used as the measurement method.

Presurgical assessment of flow variability in an azygos vein aneurysm using 4D-flow MRI.
Takuya Ikushima, Hideki Ujiie, Satonori Tsuneta, Ryohei Chiba, Yukiko Tabata, Aki Fujiwara-Kuroda, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Tatsuya Kato
General thoracic and cardiovascular surgery, 70, 7, 673, 676, SPRINGER JAPAN KK, 2022年04月06日, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）, Azygos vein aneurysm (AVA) is necessary to prevent pulmonary embolism due to the outflow of a thrombus or rupture of the aneurysm. However, there is no established modality to assess the properties of AVA. Time-resolved three-dimensional phase-contrast magnetic resonance imaging (4D-flow MRI) has been used to examine the hemodynamics in various fields. We report a case of AVA to evaluate the flow variability and adhesions of surrounding tissues using 4D-flow MRI. The findings of the study suggested aneurysm turbulence and the absence of thrombi. The cine image, which showed a sliding wall synchronized to the heartbeat, indicated no adhesion to the superior vena cava. Based on these results, the thoracoscopic approach was deemed possible preoperatively. Thoracoscopic AVA resection was performed, and the postoperative course was uneventful. This study documented the utility of 4D-flow MRI for a detailed evaluation of AVA.

Elective Uniportal Video-Assisted Thoracoscopic Lobectomy for Congenital Cystic Lung Disease in a 2-Year-Old Child Using One-Lung Ventilation
Haruhiko Shiiya, Hideki Ujiie, Tatsuya Kato, Shohei Honda, Satoru Wakasa, Kichizo Kaga
INDIAN JOURNAL OF SURGERY, 85, 552, 555, SPRINGER INDIA, 2022年04月, ［査読有り］
英語, 研究論文（学術雑誌）, To the best of our knowledge, no previous reports have described the indication criteria and details of uniportal video-assisted thoracoscopic lobectomy in younger children. We report the utility of uniportal video-assisted thoracoscopic right lower lobectomy via a 2-cm incision in a 2-year-old child with a prenatal diagnosis of congenital cystic lung disease. A male infant with a prenatal diagnosis of congenital cystic lung disease was delivered vaginally at 36 weeks of gestation. Computed tomography after birth showed that the disease was limited to the right lower lobe. The patient was asymptomatic and was initially treated conservatively. At the age of 2 years and 10 months, when compensatory lung growth can still be expected, the patient had become large enough to safely undergo one-lung ventilation and thoracoscopic surgery. Therefore, we decided to perform a curative lobectomy. A single 2-cm incision was made at the anterior axillary line on the 6th intercostal space. The vessels and bronchus were approached from the anterior side. We used a 3-mm thoracoscope and instruments with a small diameter. The patient was discharged without any complications or need for analgesic drugs. The crossing technique was utilized to minimize the interference between multiple instruments in a small incision with a narrow intercostal space.

Antibody responses induced by the BNT162b2 mRNA COVID-19 vaccine in healthcare workers in a single community hospital in Japan.
Shinya Otsuka, Kei Hiraoka, Masato Suzuoki, Hideki Ujiie, Tatsuya Kato, Isao Yokota, Kazuya Yonezawa, Keiji Oguma, Nozomu Iwashiro, Mototsugu Kato, Masanori Ohara
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 28, 4, 539, 542, Elsevier {BV}, 2022年04月, ［査読有り］, ［国際誌］
英語, INTRODUCTION: The effectiveness of several vaccines against coronavirus disease (COVID-19) has been reported in the real-world setting. However, it is still unknown how long antibodies persist following vaccination and whether or not the persistence of antibodies has a protective effect against COVID-19. METHODS: Healthcare workers who had received two doses of the BNT162b2 mRNA COVID-19 vaccine were enrolled, and a single-center study was conducted at the National Hospital Organization Hakodate National Hospital. Serum samples from all participants were collected 13-21 weeks (median: 20 weeks) after the second dose of vaccination. The antibody titers were measured using an electrochemiluminescence immunoassay (Elecsys® Anti-SARS-CoV-2 S). Data on characteristics of the participants were gathered from patient records and interview sheets. RESULTS: A total of 401 participants, among whom 70.1% were women and the median age was 42 years, were evaluated in this study. None of the participants had a definite COVID-19 history, and all participants who received complete vaccination showed positive antibody titers. The antibody titer was observed to be higher in participants with younger age (p < 0.001) and those who were females (p = 0.028). Despite the higher risk of infection than that of the general public, no vaccinated staff developed breakthrough infections. CONCLUSIONS: This study demonstrates the significant contribution of the BNT162b2 vaccine in the acquisition of anti-SARS-CoV-2S antibodies; therefore, the general population should benefit from these two vaccine doses, which are expected to be protective for at least five months.

Endobronchial ultrasound-guided bipolar radiofrequency ablation for lung cancer: A first-in-human clinical trial.
Tsukasa Ishiwata, Yamato Motooka, Hideki Ujiie, Terunaga Inage, Alexander Gregor, Masato Aragaki, Zhenchian Chen, Tomonari Kinoshita, Laura Donahoe, Jonathan Yeung, Marcelo Cypel, Marc de Perrot, Andrew Pierre, Gail Darling, Thomas Waddell, Shaf Keshavjee, Prodipto Pal, Kazuhiro Yasufuku
The Journal of thoracic and cardiovascular surgery, 164, 4, 1188, 1197, 2022年03月26日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVE: Percutaneous radiofrequency ablation (RFA) is a therapeutic option for lung tumors. However, percutaneous approaches have limited access to central lung regions and a relatively high complication rate. To overcome these limitations, a needle-type bipolar RFA device compatible with an endobronchial ultrasound (EBUS) bronchoscope was developed. The aim of this pilot study was to evaluate the immediate-term safety and ablation zone of lung tumor EBUS-guided RFA. METHODS: This was an ablate-and-resect study in patients scheduled for surgical resection of clinical stage I or II lung cancer or metastatic lung lesions ≥1 cm that were accessible using an EBUS bronchoscope. The RFA electrodes were placed within the lung nodule using EBUS guidance followed by ablation. Bronchoscopy and contrast-enhanced computed tomography were performed to evaluate for post-RFA complications. The resected lung underwent pathological assessment to characterize the ablation zone. RESULTS: A total of 5 primary lung cancers were ablated in 5 separate patients; no patients with metastatic lesions were recruited. For a total energy of 4 kJ (n = 3), 6 kJ (n = 1), and 8 kJ (n = 1) delivered, the ablation time was a mean of 13.8 (range, 10.3-16.0) minutes, 8.4 minutes, and 15.6 minutes, respectively, and the maximum ablation diameter was a mean of 1.8 (range, 1.3-2.1) cm, 2.7 cm, and 2.6 cm, respectively. No immediate post-RFA complications were observed. CONCLUSIONS: EBUS-guided bipolar RFA can ablate lung tumors using real-time ultrasound guidance. EBUS-guided RFA might ultimately represent a minimally invasive therapy for lung cancer in patients unable to tolerate surgery. Longer-term safety will need to be evaluated.

Development of a minimally invasive pulmonary porcine embolism model via endobronchial ultrasound.
Terunaga Inage, Kosuke Fujino, Yamato Motooka, Tsukasa Ishiwata, Hideki Ujiie, Alexander Gregor, Nicholas Bernards, Harley H L Chan, Zhenchian Chen, Masato Aragaki, Tomonari Kinoshita, Andrew Effat, Ichiro Yoshino, Kazuhiro Yasufuku
Journal of thoracic disease, 14, 2, 238, 246, AME PUBL CO, 2022年02月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: Current massive pulmonary embolism (PE) animal models use central venous access to deliver blood clots, which have features of random clot distribution and potentially fatal hemodynamic compromise. A clinically relevant preclinical model for generating pulmonary emboli in a more controlled fashion would be of value for a variety of research studies, including initial evaluation of novel therapeutic approaches. Endobronchial ultrasound-guided transbronchial needle injection (EBUS-TBNI) is a newly established approach for peri-tracheal/bronchial targets. The purpose of the present work was to establish a minimally invasive PE model in swine via a transbronchial approach. Methods: In anesthetized Yorkshire pigs, a 21-G EBUS-guided transbronchial needle aspiration (EBUS-TBNA) needle was introduced into the pulmonary artery under EBUS guidance. Autologous blood clots were administered into the right and left lower pulmonary arteries sequentially (PE1 and PE2, respectively). Hemodynamic and biochemical responses were evaluated. Results: Ten pigs were evaluated; all 20 blood clots (6.3±1.9 mL) were successfully injected. After injection, mean pulmonary artery pressure (mPAP; mmHg) increased (baseline: 16.6±5.6 vs. PE1: 24.5±7.6, P<0.0001 vs. PE2: 26.9±6.7, P<0.0001), and a positive correlation was observed between clot volume and change in mPAP (PE1: r=0.69, P=0.025; PE1 + PE2: r=0.60, P=0.063). Mean arterial pressure (MAP; mmHg) (baseline: 57.5±5.1 vs. PE1: 59.0±9.1, P=0.918 vs. PE2: 60.9±9.6, P=0.664) remained stable. No complications were observed. Conclusions: EBUS allows minimally invasive, precise, and reliable generation of pulmonary emboli in pigs. This model may serve as an important tool for new PE-related diagnostic and therapeutic research.

PRECLINICAL EVALUATION OF THIN CONVEX PROBE ENDOBRONCHIAL ULTRASOUND-GUIDED TRANSBRONCHIAL NEEDLE ASPIRATION FOR INTRAPULMONARY LESIONS
Tsukasa Ishiwata, Terunaga Inage, Alexander Gregor, Yamato Motooka, Harley Chan, Masato Aragaki, Nicholas Bernards, Zhenchian Chen, Hideki Ujiie, Tomonari Kinoshita, Andrew Effat, Koichiro Tatsumi, Kazuhiro Yasufuku
CHEST, 160, 4, 2031A, 2032A, ELSEVIER, 2021年10月, ［査読有り］
英語

Surgical treatment for tracheal stent prolapse in a patient with blunt tracheal trauma.
Shinya Otsuka, Tatsuya Kato, Hideki Ujiie, Aki Fujiwara-Kuroda, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Yuta Takashima, Naofumi Shinagawa
General thoracic and cardiovascular surgery, 69, 12, 1589, 1592, SPRINGER JAPAN KK, 2021年09月28日, ［査読有り］, ［責任著者］, ［国内誌］
英語, Blunt tracheal injury is a rare but life-threatening condition. Several indications for treatment have been reported. Conservative treatment (i.e., stenting) can be performed when the patient is clinically stable or has medical contraindications to surgical treatment. Although some studies have reported the use of tracheal stents as treatment for iatrogenic injury and blunt trauma, the efficacy of these stents is unknown. Herein, we report a case of emergency tracheoplasty for the management of tracheal stent prolapse in a patient with blunt tracheobronchial trauma. This report highlights the necessity of being cautious about the migration and prolapse of tracheal stents, which can more frequently occur in blunt trauma than in malignant stenosis or iatrogenic injury. Due to the limitations of non-surgical treatments, early surgical intervention may be lifesaving.

Elevated serum CYFRA 21-1 level as a diagnostic marker for thymic carcinoma.
Haruhiko Shiiya, Hideki Ujiie, Yasuhiro Hida, Tatsuya Kato, Kichizo Kaga, Satoru Wakasa, Eiki Kikuchi, Naofumi Shinagawa, Kazufumi Okada, Yoichi M Ito, Yoshihiro Matsuno
Thoracic cancer, 12, 21, 2933, 2942, Wiley, 2021年09月27日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: No useful tumor markers have been identified for the diagnosis of thymic carcinomas. Serum cytokeratin 19 fragment, measured using the CYFRA 21-1 immunoassay, is used as a tumor marker for squamous cell carcinomas in various malignant tumors. Here, we evaluated the value of CYFRA 21-1 in diagnosing thymic carcinoma. METHODS: We retrospectively reviewed 94 patients with pathological diagnoses of thymic carcinoma or thymoma (32 and 62 patients, respectively) who were referred to our departments between January 2000 and March 2019. Primary outcomes included tumor marker levels and their diagnostic accuracy. RESULTS: Patients with thymic carcinoma were significantly more likely to be male (thymic carcinoma, 68.8%; thymoma, 40.3%; p = 0.02), have an advanced TNM stage (p < 0.01), and a significantly higher CYFRA 21-1 level than those with thymoma (thymic carcinoma: median = 4.2 ng/ml; interquartile range [IQR] = 2.1-6.1 ng/ml vs. thymoma: median = 1.2 ng/ml; IQR = 0.9-1.7 ng/ml; p < 0.01). Receiver operating characteristic curves demonstrated that the area under the curve for CYFRA 21-1 to distinguish thymic carcinoma from thymoma was 0.86 (95% confidence interval [CI]: 0.74-0.93; cutoff = 2.7 ng/ml; sensitivity = 68.8%; specificity = 95.2%). Multivariable analysis demonstrated that CYFRA 21-1 (odds ratio = 25.6; 95% CI: 4.6-141.6; p < 0.01) was an independent predictor for thymic carcinoma after adjusting for TNM stage. CONCLUSIONS: Serum CYFRA 21-1 level may help in diagnosing thymic carcinoma.

A Novel Treatment of Widespread Empyema Necessitatis.
Shinya Otsuka, Hideki Ujiie, Kosuke Ishikawa, Takahiro Miura, Satoru Wakasa, Tatsuya Kato
The Annals of thoracic surgery, 112, 6, e471, E471, ELSEVIER SCIENCE INC, 2021年09月04日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery.
Akihiro Sasaki, Tatsuya Kato, Hideki Ujiie, Satoru Wakasa, Setsuyuki Otake, Keisuke Kikuchi, Koichi Ohno
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 28, 6, 448, 452, 「Annals of Thoracic and Cardiovascular Surgery」編集委員会, 2021年07月16日, ［査読有り］, ［責任著者］, ［国内誌］
英語, INTRODUCTION: Stiff-person syndrome (SPS) is a rare autoimmune neurological disorder. Paraneoplastic SPS associated with malignant tumors such as thymoma occurs in approximately 5% of all SPS cases. We present a rare case of thymoma accompanied by SPS successfully treated using surgery. PRESENTATION OF CASE: A 26-year-old woman presented with lower limbs convulsions and gait disturbance and complained of leg pain. Cerebrospinal fluid and blood test results showed a high level of anti-glutamic acid decarboxylase (GAD) antibodies. Computed tomography showed anterior mediastinal tumor suggestive of a thymoma. She underwent extended thymectomy, and her symptoms gradually improved after surgery. No evidence of recurrent thymoma and SPS has been observed over 44 months. CONCLUSION: Surgical treatment would be effective for patients with SPS and thymoma.

Rare Diagnosis of a Multilobular Pulmonary Mass.
Yoshinobu Watabe, Hideki Ujiie, Yoshihiro Matsuno, Hideaki Fukui, Aki Fujiwara-Kuroda, Tatsuya Kato, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa
Chest, 160, 1, e63-e67, E67, ELSEVIER, 2021年07月, ［査読有り］, ［責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）, CASE PRESENTATION: A 57-year-old woman was admitted to our hospital for an abnormal chest shadow found during routine chest radiography. She had no respiratory symptoms. Her medical history included dyslipidemia, and her surgical history included conization for cervical cancer at age 38 years. She was a social drinker and ex-smoker of approximately 10 cigarettes per day (from ages 20 to 30 years); she denied recreational drug use.

肺梗塞切除後の肺塞栓症の予測:症例シリーズ
Yamasaki Hiroshi, Ujiie Hideki, Kato Tatsuya, Hida Yasuhiro, Kaga Kichizo, Wakasa Satoru, Matsuno Yoshihiro
Annals of Thoracic and Cardiovascular Surgery (Web), 27, 6, 371, 379, Editorial Committee of Annals of Thoracic and Cardiovascular Surgery, 2021年05月14日, ［査読有り］, ［国内誌］
英語, PURPOSE: Pulmonary nodules suspected to be cancerous are rarely diagnosed as pulmonary infarction (PI). This study examined the clinical, radiological, and laboratory data in cases diagnosed with PI to determine their potential utility as preoperative diagnostic markers. We also assessed factors affecting the postoperative course. METHODS: A total of 603 cases of peripheral pulmonary nodules undiagnosed preoperatively were resected at Hokkaido University Hospital from 2012 to 2019. Of these, we reviewed cases with a postoperative diagnosis of PI. We investigated clinical symptoms, preoperative laboratory data, radiological characteristics, and postoperative complications. RESULTS: Four patients (0.7%) were diagnosed with PI. All patients had a smoking history. One patient received systemic steroid administration, and none had predisposing factors for thrombosis. One case showed chronologically increased nodule size. Three cases showed weak uptake of 18F-fluorodeoxyglucose. One patient with preoperative high D-dimer levels developed a massive pulmonary embolism (PE) in the postoperative chronic phase and was treated with anticoagulants. CONCLUSIONS: Preoperative diagnosis of PI is difficult, and we could not exclude lung cancer. However, if a patient diagnosed with PI has a high D-dimer level, we recommend postoperative physical examination for deep venous thrombosis. Prophylactic anticoagulation therapy should be considered to avoid fatal PE.

Pilot study using virtual 4-D tracking electromagnetic navigation bronchoscopy in the diagnosis of pulmonary nodules: a single center prospective study.
Tsukasa Ishiwata, Hideki Ujiie, Alexander Gregor, Terunaga Inage, Yamato Motooka, Tomonari Kinoshita, Masato Aragaki, Zhenchian Chen, Andrew Effat, Nicholas Bernards, Kazuhiro Yasufuku
Journal of thoracic disease, 13, 5, 2885, 2895, AME PUBL CO, 2021年05月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: Electromagnetic navigation bronchoscopy (ENB) is a navigation technology intended to improve the diagnostic yield of pulmonary nodules. However, nodule displacement due to respiratory motion may compromise the accuracy of the navigation guidance. The Veran SPiNDrive ENB system employs respiratory-gating (4D-tracking) to compensate for this motion. The aim of the present study was to evaluate the diagnostic performance and safety of the Veran SPiNDrive system for biopsy of pulmonary nodules. Methods: Adult patients with pulmonary nodules of ≥1 cm were enrolled at a single center. Both conventional bronchoscopy and 4D-tracking ENB were performed in one procedure session under general anesthesia, with the procedure order being randomly assigned. Radial probe endobronchial ultrasound and fluoroscopy were used in both groups. The diagnostic performance, safety, total procedure time, and total fluoroscopy time of the ENB phase were compared to the corresponding conventional bronchoscopy phase. Results: The study was terminated due to poor accrual; a total of eleven patients were enrolled. The mean size of pulmonary nodules was 2.1 cm. The sensitivity for malignancy was 67% (6/9) and 56% (5/9) with conventional bronchoscopy and with 4D-tracking ENB, respectively. Two cases developed minor bleeding after conventional bronchoscopy, while no complications were observed after 4D-tracking ENB. The mean procedure time was 16.1 and 21.7 min (P=0.090), and the mean duration time for fluoroscopy use was 77 and 44 sec (P=0.056) for the conventional bronchoscopy and the 4D-tracking ENB phases, respectively. Conclusions: The diagnostic performance of the Veran SPiNDrive 4D-tracking ENB did not exceed that of conventional bronchoscopy for pulmonary nodules. No complications were seen during 4D-tracking ENB. A study with a larger number of participants is required for further assessment.

Risk stratification model for patients with stage I invasive lung adenocarcinoma based on clinical and pathological predictors.
Yiyang Wang, Difan Zheng, Jizhuang Luo, Jie Zhang, Cecilia Pompili, Hideki Ujiie, Natsumi Matsuura, Haiquan Chen, Feng Yao
Translational lung cancer research, 10, 5, 2205, 2217, AME PUBL CO, 2021年05月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: The aim of this study was to propose a new kind of pathological classification and further establish a prognostic model for resected stage I invasive adenocarcinoma (IADC). Methods: Clinicopathological data were collected from 2 hospitals. The new proposed pathological reclassification was defined according to certain subtype instead of a predominant one. Survival curves were plotted by Kaplan-Meier analysis. Cox regressions were analyzed for recurrence-free survival (RFS) and overall survival (OS), through which prognostic scores and stratification models were established. The comparison between risk models and the eighth edition of tumor, node, metastasis (TNM) classification was conducted through receiver operating characteristic curves (ROC), as identified by the area under the curve (AUC) and z test. Results: In all, 1,196 patients were enrolled. At multivariable analysis, solid and micropapillary of the new pathological reclassification, along with stage IA3 and IB were independent predictors for poorer RFS. Stage IB and smoking status significantly indicated worse OS. After normalization and standardization of log-hazard ratio (HR), personalized scores were calculated and the risk stratifications with 3 risk groups were generated. Compared with TNM classification, the risk model of RFS showed advantage over early-recurrence prediction (1-year: 0.653 vs. 0.556, P=0.033; 3-year: 0.663 vs. 0.076, P=0.008). No marked difference was observed in long-term RFS or OS. Conclusions: Considering the harboring of certain patterns may be a new concept in adenocarcinoma classification. The risk stratification model based on this pathological classification and the eighth TNM classification showed remarkable superiority over TNM alone in predicting early recurrence of stage I adenocarcinoma. However, TNM classification remained valuable for long-term recurrence and survival prediction.

Pneumatosis Intestinalis After Living Donor Lung Transplantation Associated With Alpha-Glucosidase Inhibitor Treatment: A Case Report.
Shinya Otsuka, Hideki Ujiie, Tatsuya Kato, Haruhiko Shiiya, Aki Fujiwara-Kuroda, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Rei Inoue, Yasuaki Iimura
Transplantation proceedings, 53, 4, 1379, 1381, ELSEVIER SCIENCE INC, 2021年05月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, INTRODUCTION: Pneumatosis intestinalis (PI) is a rare but critical condition in which gas is found in the bowel wall. Although organ transplant recipients have an increased PI risk because of long-term immunosuppression, alpha-glucosidase inhibitors (α-GI), a standard diabetes therapy, often contribute to PI. However, little is known about the postorgan transplantation relationship between PI and α-GI. To the best of our knowledge, this is the first reported case of PI in a lung transplant recipient treated with α-GI. CASE REPORT: A 59-year-old man underwent hybrid (living-donor and cadaveric) lung transplantation (LTx). The patient was treated with prednisolone and tacrolimus as immunosuppressive therapy and α-GI for diabetes for 4 years. He developed asymptomatic PI 1031 days after transplantation without any acute abdominal finding. After excluding other possible causes of PI, his PI was attributed to α-GI. The suspected α-GI was immediately withdrawn. The patient was managed conservatively with bowel rest and oxygen therapy. After 11 days of α-GI discontinuation, PI improved, and the patient completely recovered. CONCLUSION: Physicians should keep this rare adverse drug reaction in mind when prescribing α-GI, particularly in patients with diabetes after organ transplantation and including LTx. The management strategy for asymptomatic PI caused by α-GI is the immediate discontinuation of α-GI therapy, followed by conservative management initiation.

A novel Tn antigen epitope-recognizing antibody for MUC1 predicts clinical outcome in patients with primary lung adenocarcinoma.
Tatsuya Kato, Hideki Ujiie, Kanako C Hatanaka, Ayae Nange, Asami Okumura, Kaho Tsubame, Kentato Naruchi, Masaharu Sato, Kichizo Kaga, Yoshihiro Matsuno, Satoru Wakasa, Yutaka Hatanaka
Oncology letters, 21, 3, 202, 202, SPANDIDOS PUBL LTD, 2021年03月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Mucin 1 (MUC1) expression is upregulated in multiple types of cancer, including lung cancer. However, the conventional anti-MUC1 antibody is not useful for the differentiation of malignant lung tumors and benign lesions due to its limited specificity. Our previous study screened a novel epitope-defined antibody against cancer-associated sugar chain structures that specifically recognizes the MUC1 Tn antigen (MUC1-Tn ED Ab). In the present study, its potential utility as a diagnostic marker and therapeutic tool for lung adenocarcinoma (ADC) was examined. Immunohistochemical analysis of a lung ADC tissue microarray was performed using the MUC1-Tn ED Ab (clone SN-102), and the results were compared with those of another clone and commercially available MUC1 antibodies. The association between positive immunoreactivity of SN-102 and clinicopathologic factors was analyzed. Furthermore, the association between MUC1-Tn expression and epithelial-mesenchymal transition markers and radiological characteristics was analyzed. Moderate or high MUC1-Tn expression (MUC1-Tn-H) was observed in 138 (78.9%) of the 175 lung ADC cases. MUC1-Tn-H was associated with male sex, cigarette smoking, tumor extension, pleural invasion, and higher preoperative serum carcinoembryonic antigen and cytokeratin 19 fragment levels. Tumors with MUC1-Tn-H had higher consolidation/tumor ratios according to computed tomography and greater uptakes of 18F-fluorodeoxyglucose. A total of 46 (26.9%) of the tumors had mesenchymal features, and MUC1-Tn positivity was higher in the mesenchymal group than in the epithelial and intermediate groups (P<0.01 and P<0.01, respectively). Patients with tumors exhibiting MUC1-Tn-H had significantly shorter 5-year overall and disease-free survival times (P=0.011 and P<0.001, respectively). Additionally, MUC1-Tn-H was identified as an independent prognostic factor in multivariate analysis (P=0.024). MUC1-Tn is specific for lung cancer cells and can improve diagnostic capabilities. Additionally, it may be a potential therapeutic target in lung ADC.

Developing a virtual reality simulation system for preoperative planning of thoracoscopic thoracic surgery.
Hideki Ujiie, Aogu Yamaguchi, Alexander Gregor, Harley Chan, Tatsuya Kato, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Chad Eitel, Tod R Clapp, Kazuhiro Yasufuku
Journal of thoracic disease, 13, 2, 778, 783, AME PUBL CO, 2021年02月, ［査読有り］, ［筆頭著者, 責任著者］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: Video-assisted thoracoscopic surgery (VATS) has become a standard approach for the treatment of lung cancer. However, its minimally invasive nature limits the field of view and reduces tactile feedback. These limitations make it vital that surgeons thoroughly familiarize themselves with the patient's anatomy preoperatively. We have developed a virtual reality (VR) surgical navigation system using head-mounted displays (HMD). The aim of this study was to investigate the potential utility of this VR simulation system in both preoperative planning and intraoperative assistance, including support during thoracoscopic sublobar resection. Methods: Three-dimensional (3D) polygon data derived from preoperative computed tomography data was loaded into BananaVision software developed at Colorado State University and displayed on an HMD. An interactive 3D reconstruction image was created, in which all the pulmonary structures could be individually imaged. Preoperative resection simulations were performed with patient-individualized reconstructed 3D images. Results: The 3D anatomic structure of pulmonary vessels and a clear vision into the space between the lesion and adjacent tissues were successfully appreciated during preoperative simulation. Surgeons could easily evaluate the real patient's anatomy in preoperative simulations to improve the accuracy and safety of actual surgery. The VR software and HMD allowed surgeons to visualize and interact with real patient data in true 3D providing a unique perspective. Conclusions: This initial experience suggests that a VR simulation with HMD facilitated preoperative simulation. Routine imaging modalities combined with VR systems could substantially improve preoperative planning and contribute to the safety and accuracy of anatomic resection.

Primary pulmonary lymphoepithelioma-like carcinoma with positive expression of Epstein-Barr virus and PD-L1: A case report.
Akihiro Sasaki, Tatsuya Kato, Hideki Ujiie, Yasushi Cho, Masaaki Sato, Mitsuhito Kaji
International journal of surgery case reports, 79, 431, 435, ELSEVIER SCI LTD, 2021年02月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, INTRODUCTION AND IMPORTANCE: Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare type of non-small cell lung cancer (NSCLC) that is classified as a subtype of unclassified carcinoma by the WHO. LELC is usually associated with Epstein-Barr virus (EBV) infection. LELC has often been observed in Southeast Asia; however, it is extremely rare in Japan. CASE PRESENTATION: A 60-year-old Japanese woman presented with an abnormal shadow in the left lung on chest radiography. Chest computed tomography showed a nodule located between the lingular and basal anteromedial segments. A blood test suggested an existing EBV infection, and LELC was suspected preoperatively in the transbronchial lung biopsy. She underwent a lingular and basal bi-segmentectomy. The EBV-encoded small ribonucleic acid in-situ hybridization (EBER-ISH) was positive, and she was diagnosed with LELC. Moreover, programmed death-ligand 1 (PD-L1) expression was moderately positive. No recurrence was observed for 30 months. CLINICAL DISCUSSION: Although LELC has been reported as a low-grade malignancy with a good prognosis, the frequency of PD-L1 expression in LELC seems to be higher than that in other NSCLCs. Moreover, it has been reported that LELC patients with high PD-L1 expression are likely to have early recurrence/metastasis and poor prognosis. CONCLUSION: An investigation of PD-L1 expression for LELC would be useful considering the benefit of PD-1/PD-L1 blockade in patients with pulmonary LELC with high PD-L1 expression. The present case is the first report of LELC with positive expression of EBER-ISH and PD-L1 in Japan.

A preclinical research platform to evaluate photosensitizers for transbronchial localization and phototherapy of lung cancer using an orthotopic mouse model.
Tsukasa Ishiwata, Takeshi Seki, Alexander Gregor, Masato Aragaki, Yamato Motooka, Tomonari Kinoshita, Terunaga Inage, Nicholas Bernards, Hideki Ujiie, Zhenchian Chen, Andrew Effat, Juan Chen, Gang Zheng, Koichiro Tatsumi, Kazuhiro Yasufuku
Translational lung cancer research, 10, 1, 243, 251, AME PUBL CO, 2021年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: Establishing the efficacy of novel photosensitizers (PSs) for phototherapy of lung cancer requires in vivo study prior to clinical evaluation. However, previously described animal models are not ideal for assessing transbronchial approaches with such PSs. Methods: An ultra-small parallel-type composite optical fiberscope (COF) with a 0.97 mm outer diameter tip. The integration of illumination and laser irradiation fibers inside the COF allows simultaneous white-light and fluorescence imaging, as well as real-time monitoring of tip position during laser phototherapy. An orthotopic lung cancer mouse model was created with three human lung cancer cell lines transbronchially inoculated into athymic nude mice. The COF was inserted transbronchially into a total of 15 mice for tumor observation. For in vivo fluorescence imaging, an organic nanoparticle, porphysome, was used as a PS. Laser excitation through the COF was performed at 50 mW using a 671 nm source. Results: The overall success rate for creating orthotopic lung tumors was 71%. Transbronchial white light images were successfully captured by COF. Access to the left main bronchus was successful in 87% of mice (13/15), the right main bronchus to the cranial lobe bronchus level in 100% (15/15), and to the right basal trifurcation of the middle lobe, caudal lobe and accessory lobe in 93% (14/15). For transbronchial tumor localization of orthotopic lung cancer tumors, PS-laden tumor with the strong signal was clearly contrasted from the normal bronchial wall. Conclusions: The ultra-small COF enabled reliable transbronchial access to orthotopic human lung cancer xenografts in vivo. This method could serve as a versatile preclinical research platform for PS evaluation in lung cancer, enabling transbronchial approaches in in vivo survival models inoculated with human lung cancer cells.

Thrombolysis of Pulmonary Emboli via Endobronchial Ultrasound-Guided Transbronchial Needle Injection.
Terunaga Inage, Kosuke Fujino, Yamato Motooka, Tsukasa Ishiwata, Hideki Ujiie, Nicholas Bernards, Alexander Gregor, Zhenchian Chen, Masato Aragaki, Tomonari Kinoshita, Ichiro Yoshino, Kazuhiro Yasufuku
The Annals of thoracic surgery, 112, 2, 395, 404, ELSEVIER SCIENCE INC, 2020年10月24日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Endobronchial ultrasound-guided transbronchial needle injection (EBUS-TBNI) is a novel technique for treating peribronchial targets. The aim of this study was to evaluate preliminary feasibility of thrombolysis of pulmonary emboli via EBUS-TBNI. METHODS: Yorkshire pigs (30-48 kg) were anesthetized and mechanically ventilated. Pre-formed autologous clots were injected sequentially into bilateral lower pulmonary arteries in bilateral models (PE1 and PE2, respectively) or into 1 side in unilateral models using a 21-gauge EBUS-TBNA needle under EBUS guidance. In the bilateral model, 2 hours after clot injection either 25 mL of tissue-plasminogen activator (t-PA; 1mg/mL) or distilled water were administered into each embolus via 25-gauge EBUS-TBNA needle. In the unilateral model, 25 mg t-PA was administered intravenously. Hemodynamic parameters were monitored continuously, and clot dissolved volume was evaluated by EBUS 30 minutes post-treatment administration. RESULTS: All clots (6.1 ± 1.7 mL) were successfully injected as documented by EBUS Doppler imaging. Clot injection in the bilateral model (n = 6) increased pulmonary arterial pressure (mm Hg: Baseline 19.2 ± 5.9 vs PE1: 26.7 ± 9.1, P = .005 vs PE2 29.9 ± 7.1, P = .0007). After t-PA TBNI in the bilateral model (n = 6), pulmonary arterial pressure at 30 minutes post-injection showed improvement (mm Hg: PE2 29.9 ± 7.1 vs post-t-PA 24.4 ± 3.9, P = .0283). Treatment with t-PA TBNI demonstrated superior clot dissolution at 30 minutes post-treatment (dissolved mm3: t-PA TBNI 625.4 ± 156.6 vs t-PA intravenously: 181.6 ± 94.3, P = .0003 vs distilled water TBNI 42.5 ± 33.0, P < .0001). There were no complications. CONCLUSIONS: EBUS-guided transbronchial thrombolysis may be a feasible approach for treating central pulmonary emboli.

A Novel Insertion Technique for the Extra-Long Montgomery T-Tube in Patients with a Large Mediastinal Tumor.
Tatsuya Kato, Aki Fujiwara-Kuroda, Nobuyuki Shiina, Masato Aragaki, Hideki Ujiie, Yasuhiro Hida, Kichizo Kaga
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 26, 5, 294, 297, 「Annals of Thoracic and Cardiovascular Surgery」編集委員会, 2020年10月21日, ［査読有り］, ［国内誌］
英語, 研究論文（学術雑誌）, The Montgomery T-tube is widely used to stent airway stenotic diseases. Conventional insertion methods can sometimes fail in the case of long-distance subglottic stenosis due to the flexibility of a T-tube made of silicon, which kinks when forced against resistance. Therefore, an alternative approach can assist in the insertion of an extra-long T-tube, especially when using a long proximal limb. We report herein the case of a patient with a large mediastinal tumor caused by neurofibromatosis type 1 in which airway obstruction was avoided through the use of a novel extra-long T-tube placement technique.

Sentinel lymph node biopsy for lung cancer.
Alexander Gregor, Hideki Ujiie, Kazuhiro Yasufuku
General thoracic and cardiovascular surgery, 68, 10, 1061, 1078, シュプリンガー・ジャパン(株), 2020年10月, ［査読有り］, ［国内誌］
英語, Sentinel lymph node biopsy is a technique to identify the first lymph node (or nodes) draining a tumor. The underlying principle is that as the first site of cancer spread, evaluation of the sentinel node will be most predictive for wider nodal involvement. The introduction of sentinel node biopsy revolutionized the surgical management of cutaneous melanoma and breast cancer, becoming a key component in the management of such patients. For over 20 years, thoracic surgeons have similarly worked to apply this technique to lung cancer but have thus far not had the same impact on lung surgery. In this review, we will summarize the ongoing discussions on the role of sentinel node biopsy in lung cancer, the methods for identifying the sentinel node, and the techniques for evaluating the sentinel node specimen. We will also highlight some of the pressing questions investigators should consider when designing a trial for sentinel node mapping. This will clarify the current status of sentinel node biopsy in lung cancer and thus highlight important future directions for research.

Endobronchial Ultrasound-Guided Radiofrequency Ablation of Lung Tumors and Mediastinal Lymph Nodes: A Preclinical Study in Animal Lung Tumor and Mediastinal Adenopathy Models
Yamato Motooka, Kosuke Fujino, Alexander Gregor, Nicholas Bernards, Harley Chan, Terunaga Inage, Hideki Ujiie, Tatsuya Kato, Tomonari Kinoshita, Tsukasa Ishiwata, Makoto Suzuki, Kazuhiro Yasufuku
Seminars in Thoracic and Cardiovascular Surgery, 32, 3, 570, 578, ELSEVIER INC, 2020年09月, ［査読有り］, ［国際誌］
英語, 研究論文（国際会議プロシーディングス）, © 2020 Elsevier Inc. Radiofrequency ablation (RFA) can be a therapeutic option in medically inoperable lung cancer patients. In this study, we evaluated a prototype bipolar RFA device applicator that can be deployed from a standard endobronchial ultrasound (EBUS) bronchoscope to determine feasibility and histopathological analysis in animal models. Rabbit lung cancers were created by transbronchial injection of VX2 rabbit cancer cells. Once the tumors were developed, they were ablated transpleurally, under EBUS guidance using the prototype RFA device. The animals were then sacrificed for specimen resection. Pig inflammatory lung pseudo-tumors and lymphadenopathy were created by transbronchial injection of a talc paste and ablated transbronchially under EBUS guidance. Pigs were evaluated at 5 days, 2 weeks, and 4 weeks following ablation by bronchoscopy and cone beam computed tomography before necropsy. Nicotinamide adenine dinucleotide hydrogen diaphorase staining was employed to measure the ablation area. Twenty-four VX2 rabbit tumors were ablated. The total ablated area ranged from 0.6 to 3.0 cm2 (mean: 1.8 cm2), corresponding to a total energy range of 1 to 6 kJ. Six pig lung pseudo-tumors and 5 mediastinal lymph nodes were ablated. Adjacent airway ulceration was observed in 3 ablations of lymph nodes. These airway complications resolved within 4 weeks of RFA without any treatment. There was no hemoptysis, air embolism, respiratory distress, or other serious complication noted. In these 2 animal models, we provide evidence that EBUS-guided bipolar RFA is feasible and histopathology shows that can ablate lung tumors and mediastinal lymph nodes under real-time ultrasound guidance.

Photoacoustic imaging to localize indeterminate pulmonary nodules: A preclinical study.
Chang Young Lee, Kosuke Fujino, Yamato Motooka, Alexander Gregor, Nicholas Bernards, Hideki Ujiie, Tomonari Kinoshita, Kyung Young Chung, Seung Hee Han, Kazuhiro Yasufuku
PloS one, 15, 4, e0231488, PUBLIC LIBRARY SCIENCE, 2020年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: Diagnosis and resection of indeterminate pulmonary nodules (IPNs) is a growing challenge with increased utilization of chest computed tomography. Photoacoustic (PA) -guided surgical resection with local injection of indocyanine green (ICG) may have utility for IPNs that are suspicious for lung cancer. This preclinical study explores the potential of PA imaging (PAI) to detect ICG-labeled tumors. MATERIALS AND METHODS: ICG uptake by H460 lung cancer cells was evaluated in vitro. A phantom study was performed to analyze PA signal intensity according to ICG concentration and tissue thickness/depth using chicken breast. PA signals were measured up to 48 hours after injection of ICG (mixed with 5% agar) into healthy subcutaneous tissue, subcutaneous H460 tumors and right healthy lung in nude mice. RESULTS: Intracellular ICG fluorescence was detected in H460 cells co-incubated with ICG in vitro. The concentration dependence of the PA signal was logarithmic, and PA signal decline was exponential with increasing tissue depth. The PA signal of 2 mg/mL ICG was still detectable at a depth of 22 mm in chicken breast. The PA signal from ICG mixed with agar was detectable 48 hours post injection into subcutaneous tissue and subcutaneous H460 tumors in nude mice. Similar features of PA signals from ICG-agar in mice lung were obtained. CONCLUSION: The results from this preclinical study suggests that PAI of injected ICG-agar may be beneficial for identifying deeply located tumors. These features may be valuable for IPNs.

Rabbit VX2 lung tumor models can form early nodal metastases.
Alexander Gregor, Kosuke Fujino, Nicholas Bernards, Tomonari Kinoshita, Yamato Motooka, Terunaga Inage, Tsukasa Ishiwata, Zhenchian Chen, Hideki Ujiie, Chang Young Lee, Kazuhiro Yasufuku
World journal of surgical oncology, 17, 1, 231, 231, BMC, 2019年12月29日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: The rabbit squamous cell cancer line, VX2, has been used to generate various tumor models in rabbits. It is notable for its ability to generate nodal metastases. However, the timing and extent of nodal metastases vary by primary inoculation site and methodology. The development of metastases specifically in lung cancer models has not been well-described. We sought to characterize the generation of nodal metastases in rabbit transbronchial VX2 lung tumor models. METHODS: Rabbit VX2 lung tumor models were created in the right lung via transbronchial injection and serially imaged by computed tomography. Rabbits (n = 15) were sacrificed from between 5 and 24 days post-inoculation for collection of the ipsilateral and contralateral paratracheal lymph nodes. These underwent histopathological evaluation for metastases using hematoxylin and eosin as well as cytokeratin AE1/AE3 immunohistochemical staining. RESULTS: Nodal metastases were detectable as early as 1 week after inoculation but were more prevalent with longer inoculation; all rabbits at > 2 weeks post-inoculation had nodal metastases. Contralateral metastases were in general seen later than ipsilateral metastases. Lymph node volume did not predict the likelihood of nodal metastases (p = 0.4 and p = 0.07 for ipsilateral and contralateral nodal metastases, respectively), but primary tumor volume was significantly associated with the likelihood of nodal metastases (p = 0.001 and p = 0.005 for ipsilateral and contralateral nodal metastases, respectively). Ipsilateral metastases were detectable at a tumor diameter of 1 cm; contralateral metastases were more variable but in general required a tumor diameter of 2 cm. CONCLUSIONS: Rabbit transbronchial VX2 lung tumor models generate nodal metastases relatively early after inoculation. These results suggest such models may be valuable tools in the investigation of novel therapeutic modalities relevant for the treatment of both early-stage and locally advanced lung cancer.

PRECLINICAL EVALUATION OF PROTOTYPE 21-AND 25-GAUGE SAMPLING NEEDLES USING A THIN CONVEX PROBE ENDOBRONCHIAL ULTRASOUND
Terunaga Inage, Tsukasa Ishiwata, Schwock Joerg, Yamato Motooka, Hideki Ujiie, Tomonari Kinoshita, Alexander Gregor, Nicholas Bernards, Zhenchian Chen, Andrew Effat, Ichiro Yoshino, Kazuhiro Yasufuku
CHEST, 156, 4, 924A, 925A, ELSEVIER, 2019年10月, ［査読有り］
英語

A Novel Laser Fiberscope for Simultaneous Imaging and Phototherapy of Peripheral Lung Cancer.
Tomonari Kinoshita, Andrew Effat, Alexander Gregor, Terunaga Inage, Tsukasa Ishiwata, Yamato Motooka, Hideki Ujiie, Brian C Wilson, Gang Zheng, Robert Weersink, Hisao Asamura, Kazuhiro Yasufuku
Chest, 156, 3, 571, 578, ELSEVIER, 2019年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Phototherapy is an alternative treatment for patients with localized non-small cell lung cancer who are unable to undergo surgical resection. However, phototherapy is currently limited to treatment of centrally located lung cancer, with the much larger proportion of peripheral lesions remaining inaccessible. There are also concerns over the accuracy of targeted laser treatment because of the need to exchange visualization and irradiation fibers during therapy, preventing the operator from confirming the final location of the irradiation fiber. METHODS: A newly developed parallel-type ultrasmall composite optical fiberscope (Laser-eYe Ultrathin fiberscope [LYU]), which enables simultaneous white-light imaging and phototherapy, was evaluated in preclinical lung cancer models. Three models were used: human lung cancer xenografts (A549) in mice, orthotopic VX2 lung tumors in rabbits, and ex vivo pig lungs into which A549 tumor tissue was transplanted. A multifunctional porphyrin-phospholipid nanoparticle (porphysome) was used as a photosensitizer to evaluate fluorescence-guided photothermal therapy. RESULTS: The LYU's 0.97 mm diameter and hydrophilic coating allowed easy passage through the working channel of all types of bronchoscopes and controlled guidance of the LYU tip in any desired direction. The LYU could visualize the peripheral bronchus and porphysome-laden peripheral tumors. The LYU could also perform photothermal therapy with simultaneous imaging. CONCLUSIONS: The LYU enables simultaneous imaging and phototherapy that allows accurate irradiation of peripheral lung cancers. This new laser device may enable ultraminimally invasive transbronchial treatment of peripheral lung cancer.

Minimally invasive surgical approaches for lung cancer.
Hideki Ujiie, Alexander Gregor, Kazuhiro Yasufuku
Expert review of respiratory medicine, 13, 6, 571, 578, TAYLOR & FRANCIS LTD, 2019年06月, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, Introduction: Surgery is the standard of care for early-stage non-small cell lung cancer (NSCLC), but there remains on an ongoing discussion as to what is the best surgical approach. Despite only modest adoption of minimally invasive surgery (MIS), it is now the favored approach over traditional open surgery. MIS techniques like video-assisted (VATS) and robot-assisted thoracoscopic surgery (RATS) have been demonstrated to reduce postoperative complications and shorten the length of hospitalization. Furthermore, despite unresolved questions of the oncological equivalency of MIS approaches, recent literature suggests no differences in upstaging or survival between VATS and open surgery. Area covered: We examine the current state and future direction of MIS for lung cancer in this review. Expert opinion: The perioperative benefits of VATS may make it superior to thoracotomy. There is overall insufficient clinical and patient equipoise to support a large randomized trial comparing MIS with open surgery at this time, but this may change in the presence of compelling preliminary data. The growing use of RATS has thus far only shown equivalence to VATS at a higher cost. Further investigation is needed.

Evaluation of Novel Imaging Devices for Nanoparticle-Mediated Fluorescence-Guided Lung Tumor Therapy.
Tomonari Kinoshita, Hideki Ujiie, Juan Chen, Lili Ding, Harley Chan, Alexander Gregor, Nicholas Bernards, Patrick Z McVeigh, Kosuke Fujino, Chang Young Lee, Yamato Motooka, Terunaga Inage, Michael S Valic, Andrew Effat, Robert Weersink, Brian C Wilson, Gang Zheng, Hisao Asamura, Kazuhiro Yasufuku
The Annals of thoracic surgery, 107, 6, 1613, 1620, ELSEVIER SCIENCE INC, 2019年06月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Nonsurgical and minimally invasive approaches for early-stage peripheral lung cancer are needed to avoid the known morbidity of surgical resection, particularly in high-risk patients. We previously demonstrated the utility of multifunctional porphyrin-phospholipid nanoparticles (porphysomes) for fluorescence imaging and phototherapy after preferential accumulation into tumors. The objective of this study was to demonstrate the feasibility of porphysome-mediated imaging and photothermal therapy using a newly developed fiberscope and thoracoscope. METHODS: To prepare this technology for clinical translation, we developed a porphysome-specific fiberscope (scanning fiber endoscope and porphysome-specific thoracoscope), both capable of detecting porphysome fluorescence, for image-guided transbronchial and transpleural photothermal therapy to treat endobronchial/peribronchial and subpleural tumors, respectively. These were tested in three animal models: human lung cancer xenografts (A549) in mice, orthotopic VX2 lung tumors in rabbits, and ex vivo pig lung into which A549 tumor tissue was transplanted. RESULTS: The scanning fiber endoscope, with a 1.2-mm diameter, is small enough to pass through the working channel of a conventional bronchoscope and could visualize porphysome-laden tumors located inside or close to the peripheral bronchial wall. The porphysome-specific thoracoscope system had high sensitivity for porphysome fluorescence and enabled image-guided thoracoscopic resection of porphysome-accumulating tumors close to the pleura. Porphysomes also enhanced the efficacy of scanning fiber endoscope-guided transbronchial photothermal therapy and porphysome-specific thoracoscope-guided transpleural photothermal therapy, resulting in selective and efficient tumor tissue ablation in the rabbit and pig models. CONCLUSIONS: These results support the potential for clinical translation of this novel platform to affect nonsurgical and minimally invasive treatment options for early-stage peripheral lung cancer.

Image-guided pulmonary metastasectomy in the hybrid operating room
Hideki Ujiie, MD, PhD
Journal of Visualized Surgery, 2019年05月, ［査読有り］, ［筆頭著者］
研究論文（学術雑誌）

First Evaluation of the Next-Generation Endobronchial Ultrasound System in Preclinical Models.
Kosuke Fujino, Hideki Ujiie, Tomonari Kinoshita, Chang Young Lee, Hitoshi Igai, Terunaga Inage, Yamato Motooka, Alexander Gregor, Makoto Suzuki, Kazuhiro Yasufuku
The Annals of thoracic surgery, 107, 5, 1464, 1471, ELSEVIER SCIENCE INC, 2019年05月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: The next-generation convex probe endobronchial ultrasound (CP-EBUS) was developed to improve the ease of operation and the acquisition of EBUS skills for new trainees. The aim of this study was to evaluate the changes in the prototype next-generation CP-EBUS compared with the current CP-EBUS. METHODS: The prototype next-generation CP-EBUS, with a decreased forward oblique view, more flexible angulation range, smaller ultrasound probe, and sharper needle angle, was compared with the current CP-EBUS. The operability, which was evaluated by using a 5-level Likert-type scale, and safety were evaluated in 2 live pigs, a cadaveric lung, and 10 ex vivo human lungs by 9 bronchoscopists. The time required to access the upper lobe bronchus and the time required to detect prespecified lymph node stations by 7 novice bronchoscopists with both CP-EBUS were compared with assess the operability difference for new trainees. RESULTS: In all evaluated models, operability (eg, maneuverability, endoscopic visibility, bronchial trees selectivity, insertability to the upper airway) was scored 5 (significantly improved). All trainee bronchoscopists were able to access the upper lobe bronchi and detect each lymph node except 4R significantly faster than with the current CP-EBUS without any airway damage. CONCLUSIONS: The next-generation CP-EBUS has improved operability, which resulted in better access to each lobar bronchus and more prompt detection of mediastinal or hilar lymph nodes. These improvements may allow more precise lymph node staging and diagnosis, as well as improve EBUS procedural skill acquisition, once introduced to clinical practice.

末梢肺癌の画像ガイド下経気管支および経胸膜光温熱治療のナノテクノロジー対応戦略
KINOSHITA Tomonari, UJIIE Hideki, CHEN Juan, DING Lili, CHAN Harley, GREGOR Alexander, BERNARDS Nicholas, MCVEIGH Patrick Z, FUJINO Kosuke, LEE Chang Young, MOTOOKA Yamato, INAGE Terunaga, VALIC Michael, WEERSINK Robert, WILSON Brian C, ZHENG Gang, ASAMURA Hisao, YASUFUKU Kazuhiro
日本外科学会定期学術集会(Web), 119回, SF, 8:[T], (一社)日本外科学会, 2019年04月, ［査読有り］
英語

Hybrid operating room: the leading edge of thoracic surgery
Hideki Ujiie, Alexander Gregor, Kazuhiro Yasufuku
VIDEO-ASSISTED THORACIC SURGERY, 4, AME PUBL CO, 2019年03月, ［査読有り］, ［筆頭著者］
英語, 研究論文（学術雑誌）

Porphyrin-High-Density Lipoprotein: A Novel Photosensitizing Nanoparticle for Lung Cancer Therapy.
Hideki Ujiie, Lili Ding, Rong Fan, Tatsuya Kato, Daiyoon Lee, Kosuke Fujino, Tomonari Kinoshita, Chang Young Lee, Thomas K Waddell, Shaf Keshavjee, Brian C Wilson, Gang Zheng, Juan Chen, Kazuhiro Yasufuku
The Annals of thoracic surgery, 107, 2, 369, 377, ELSEVIER SCIENCE INC, 2019年02月, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: We have developed ultrasmall porphyrin-high-density lipoprotein (HDL) nanoparticles (<20 nm), called "porphyrinHDL," that have a high density of porphyrin molecules and dissociate rapidly upon tumor cell accumulation to become fluorescent and photoactive. This is introduced as a novel activatable photosensitizer for image-guided photodynamic therapy (PDT). Here, we report the studies of these nanoparticles targeted to scavenger receptor class B type I (SR-BI) expressed on lung cancer cells as a first step toward development of a minimally invasive treatment for peripheral lung cancer and metastatic lymph nodes of advanced lung cancer. METHODS: The in vitro uptake of porphyrinHDL and the corresponding PDT efficacy were evaluated in both SR-BI-positive and SR-BI-negative lung cancer cell lines. A clinically relevant orthotopic lung cancer model in mice was used to examine fluorescence activation and quantification of uptake in tumor. In addition, we investigated the effect of porphyrinHDL-mediated PDT. RESULTS: PorphyrinHDL promoted proper intracellular uptake in the H460 human lung cancer cell line. When irradiated with a 671-nm PDT laser, porphyrinHDL produced significant therapeutic effectiveness in vitro. After systemic administration in mice with orthotopic lung cancer xenografts, porphyrinHDL demonstrated selective accumulation and photoactivation in tumor with significantly enhanced disease-to-normal tissue contrast. Moreover, porphyrinHDL-PDT significantly induced cell apoptosis in lung tumors (73.2%) without toxicity in normal tissues or damage to adjacent critical structures. CONCLUSIONS: SR-BI-targeted porphyrinHDL-mediated PDT of lung cancer is selective and effective in vitro and in vivo. These initial proof-of-principle studies suggest the potential of a "smart" PDT approach for highly selective tumor ablation.

A Series of Cases Using Combined Virtual 4-D Electromagnetic Tip-Tracked Devices and Endobronchial Ultrasound in the Diagnosis of Peripheral Pulmonary Nodules
Hideki Ujiie, MD, PhD
American Journal of Respiratory and Critical Care Medicine, 2019年
研究論文（学術雑誌）

Intraoperative Near-Infrared Fluorescence-Guided Peripheral Lung Tumor Localization in Rabbit Models.
Hironobu Wada, Jinzi Zheng, Alexander Gregor, Kentaro Hirohashi, Hsin-Pei Hu, Priya Patel, Hideki Ujiie, Tatsuya Kato, Takashi Anayama, David A Jaffray, Kazuhiro Yasufuku
The Annals of thoracic surgery, 107, 1, 248, 256, ELSEVIER SCIENCE INC, 2019年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: A novel liposomal nanoparticle, CF800, that co-encapsulates indocyanine green for near-infrared (NIR) imaging and iohexol for computed tomography (CT) imaging has shown preferential tumor accumulation after intravenous injection by the enhanced permeability and retention effect. We hypothesized that CF800-enhanced NIR imaging would facilitate intraoperative localization of small lung nodules. METHODS: A rabbit VX2 lung tumor model was implemented. CF800 was injected intravenously, followed by sequential CT acquisitions to track the biodistribution of CF800. Eleven rabbits were used for NIR fluorescence evaluation after thoracotomy at time points until 7 days after injection by using a NIR fluorescence thoracoscope in vivo. Organs of interests were removed for ex vivo analysis by using NIR imaging. Tumor-to-background (inflated lung) ratio was calculated and compared among the time points. RESULTS: Both CT and NIR imaging indicated enhanced accumulation of CF800 within the VX2 tumor. NIR image analysis revealed the highest tumor-to-background ratio on days 4 and 5. High background at day 2 and low tumor signal at day 7 prevented distinct demarcation. Metastatic pulmonary small nodules (less than 2 mm in diameter) were successfully visualized by NIR imaging on day 4. However, NIR signal penetration was limited, resulting in localization failure for the few tumors deep (>0 mm) to the lung surface. CONCLUSIONS: NIR image-guided localization of small lung nodules appears to be feasible under certain conditions. However, further refinement will be required to increase tumor signal intensity and to reduce background signal from normal lung parenchyma, which is at least in part a consequence of persistent CF800 in the vasculature.

Nanoparticle-based CT visualization of pulmonary vasculature for minimally-invasive thoracic surgery planning.
Hsin-Pei Hu, Harley Chan, Hideki Ujiie, Nicholas Bernards, Kosuke Fujino, Jonathan C Irish, Jinzi Zheng, Kazuhiro Yasufuku
PloS one, 14, 1, e0209501, PUBLIC LIBRARY SCIENCE, 2019年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: To evaluate CF800, a novel lipid-based liposomal nanoparticle that co-encapsulates indocyanine green (ICG) and iohexol, for CT imaging of pulmonary vasculature in minimally-invasive thoracic surgery planning. METHODS: CF800 was intravenously administered to 7 healthy rabbits. In vivo CT imaging was performed 15 min post-injection, with a subset of animals imaged at 24h, 48h, and 72h post injection. Signal-to-background ratios (SBR) were calculated at the inferior vena cava and compared across time-points. A similar protocol was applied to 2 healthy pigs to evaluate the feasibility and efficacy in a large animal model. To evaluate the feasibility of clinical application, a survey was completed by 7 surgical trainees to assess pre- and post-injection CT images of rabbits and pigs. Responses on the discernibility of pulmonary vasculature sub-branches and comfort level to use the images for pre-operative planning were collected and analyzed. RESULTS: CF800 injection improved visualization of pulmonary vessels in both rabbit and pig models. The SBR of rabbit pulmonary vasculature was significantly higher after CF800 injection (range 3.7-4.4) compared to pre-injection (range 3.3-3.8, n = 7; p<0.05). SBR remained significantly different up to 24 hours after injection (range 3.7-4.3, n = 4; p<0.05). Trainees' evaluation found the post-injection CT images had significantly higher discernibility at the second vessel branch generation in both rabbit and pig models. Trainees identified smaller vasculature branch generations in the post-injection images compared to the pre-treatment images in both rabbit (mean 6.7±1.8 vs 5.4±2.1; p<0.05) and pig (mean 6.7±1.8 vs 5.4±2.1; p<0.05). Trainees were significantly more comfortable using post-injection images for surgical planning compared to the pre-injection images (rabbit: 8.1±1.1 vs. 4.7±2.1; pig: 7.6±2.1 vs. 4.9±2.2; p<0.05). CONCLUSION: CF800 provides SBR and contrast enhancement of pulmonary vasculature which may assist in pre-surgical CT planning of minimally invasive thoracic surgery.

Novel Thoracoscopic Navigation System With Augmented Real-Time Image Guidance for Chest Wall Tumors.
Chang Young Lee, Harley Chan, Hideki Ujiie, Kosuke Fujino, Tomonari Kinoshita, Jonathan C Irish, Kazuhiro Yasufuku
The Annals of thoracic surgery, 106, 5, 1468, 1475, ELSEVIER SCIENCE INC, 2018年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: We developed a thoracoscopic surgical navigation system with real-time augmented image guidance to assess the potential benefits for minimally invasive resection of chest wall tumors. The accuracy of localization of tumor and resection margin and the effect on task workload and confidence were evaluated in a chest wall tumor phantom. METHODS: After scanning a realistic tumor phantom by cone-beam computed tomography and registering the data into the system, three-dimensional contoured tumor and resection margin was displayed. Fifteen surgeons were asked to localize the tumor margin and surgical margins with the thoracoscope alone. The same procedure was performed with the surgical navigation system activated, and results were compared between each attempt. A questionnaire and National Aeronautics and Space Administration Task Load Index were completed after. RESULTS: The surgical navigation system significantly reduced localization error for the medial (p = 0.002) and superior tumor margin (p < 0.001), which was difficult to visualize by thoracoscopy alone. All surgical resection margins were improved circumferentially, including margins that were readily visible by thoracoscopy. National Aeronautics and Space Administration Task Load Index response scores showed a statistically significant reduction in workload in all subscales. There was a more than 50% mean reduction in workload for performance (10.1 vs 4.4, p = 0.001) and frustration (13.0 vs 5.4, p = 0.001). CONCLUSIONS: This study showed that the thoracoscopic surgical navigation system providing augmented image guidance decreased tumor localization error for regions difficult to visualize thoracoscopically and also reduced surgical margin error circumferentially, regardless of thoracoscopic visibility. This system also reduced workload and increased surgeon's confidence in localizing challenging chest wall tumors.

Preclinical investigation of folate receptor-targeted nanoparticles for photodynamic therapy of malignant pleural mesothelioma.
Tatsuya Kato, Cheng S Jin, Daiyoon Lee, Hideki Ujiie, Kosuke Fujino, Hsin-Pei Hu, Hironobu Wada, Licun Wu, Juan Chen, Rober A Weersink, Hiromi Kanno, Yutaka Hatanaka, Kanako C Hatanaka, Kichizo Kaga, Yoshiro Matsui, Yoshihiro Matsuno, Marc De Perrot, Brian C Wilson, Gang Zheng, Kazuhiro Yasufuku
International journal of oncology, 53, 5, 2034, 2046, SPANDIDOS PUBL LTD, 2018年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Photodynamic therapy (PDT) following lung-sparing extended pleurectomy for malignant pleural mesothelioma (MPM) has been investigated as a potential means to kill residual microscopic cells. High expression levels of folate receptor 1 (FOLR1) have been reported in MPM; therefore, targeting FOLR1 has been considered a novel potential strategy. The present study developed FOLR1‑targeting porphyrin-lipid nanoparticles (folate-porphysomes, FP) for the treatment of PDT. Furthermore, inhibition of activated epidermal growth factor (EGFR)-associated survival pathways enhance PDT efficacy. In the present study, these approaches were combined; FP-based PDT was used together with an EGFR-tyrosine kinase inhibitor (EGFR-TKI). The frequency of FOLR1 and EGFR expression in MPM was analyzed using tissue microarrays. Confocal microscopy and a cell viability assay were performed to confirm the specificity of FOLR1‑targeting cellular uptake and photocytotoxicity in vitro. In vivo fluorescence activation and therapeutic efficacy were subsequently examined. The effects of EGFR-TKI were also assessed in vitro. The in vivo combined antitumor effect of EGFR-TKI and FP-PDT was then evaluated. The results revealed that FOLR1 and EGFR were expressed in 79 and 89% of MPM samples, respectively. In addition, intracellular uptake of FP corresponded well with FOLR1 expression. When MPM cells were incubated with FP and then irradiated at 671 nm, there was significant in vitro cell death, which was inhibited in the presence of free folic acid, thus suggesting the specificity of FPs. FOLR1 targeting resulted in disassembly of the porphysomes and subsequent fluorescence activation in intrathoracic disseminated MPM tumors, as demonstrated by ex vivo tissue imaging. FP-PDT resulted in significant cellular damage and apoptosis in vivo. Furthermore, the combination of pretreatment with EGFR-TKI and FP-PDT induced a marked improvement of treatment responses. In conclusion, FP-based PDT induced selective destruction of MPM cells based on FOLR1 targeting, and pretreatment with EGFR-TKI further enhanced the therapeutic response.

SPECTRUM ANALYSIS OF ULTRASOUND RADIOFREQUENCY OF LUNG TUMOR IN EX-VIVO HUMAN LUNGS
Terunaga Inage, Hideki Ujiie, Alexander Gregor, Yamato Motooka, Tomonari Kinoshita, Chang Young Lee, Kosuke Fujino, Ichiro Yoshino, Kazuhiro Yasufuku
CHEST, 154, 4, 641A, 642A, ELSEVIER SCIENCE BV, 2018年10月, ［査読有り］
英語, 研究論文（学術雑誌）

MA23.10 Cone-Beam Computed Tomography-Guided Microcoil Localization of Pulmonary Nodules During Video-Assisted Thoracic Surgery
Hideki Ujiie, MD, PhD
2018年10月, ［査読有り］, ［筆頭著者］
英語, 研究論文（学術雑誌）

MA12.09 Preclinical Investigations of Folate Receptor Targeted Nanoparticles for Photodynamic Therapy of Malignant Pleural Mesothelioma
Hideki Ujiie, MD, PhD
2018年10月, ［査読有り］, ［筆頭著者］
英語, 研究論文（学術雑誌）

Developing a National, Simulation-Based, Surgical Skills Bootcamp in General Thoracic Surgery
Colin Schieman, Hideki Ujiie, Laura Donahoe, Waël Hanna, Richard Malthaner, Simon Turner, Kasia Czarnecka, Kazuhiro Yasufuku
Journal of Surgical Education, 75, 4, 1106, 1112, ELSEVIER SCIENCE INC, 2018年07月, ［査読有り］
英語, 研究論文（学術雑誌）, © 2017 Association of Program Directors in Surgery Background: The use surgical simulation across all subspecialties has gained widespread adoption in the last decade. A number of factors, including the small number of trainees, identified gaps in surgical skill training from cross-sectional surveys, increased national collaboration, and support from the national specialty committee identified a need to construct a surgical skills “bootcamp” in thoracic surgery in Canada. Objective: The goals of the surgical skills bootcamp, as identified by the residency training program directors and the national specialty committee were to create a national, centralized, simulation-based skills workshop that focused on key foundational procedures within thoracic surgery, particularly those identified as areas of weakness by former residents; to smooth the transition to intraoperative teaching; to provide exposure to important but not necessarily universally available procedures such as advanced endoscopy; to teach non-medical expert competencies, and lastly to provide a venue for networking for residents across the country. Design: The curriculum committee has constructed a 3.5 day curriculum, with a focus on hands-on skills simulation, as well as lectures, on a breadth of topics including benign esophageal disorders, lung cancer staging, minimally invasive lung surgery, crisis management and advanced bronchoscopy and endoscopy. All residents across the country attend as well as faculty from a variety of institutions. Setting: The course is hosted centrally at the University of Toronto, Ontario over 3.5 days. A combination of auditorium and both animal and human operating room facilities are utilized. Methods: A needs-assessment based on a formal meeting of the program directors, as well feedback from surveys identified the target areas for curriculum development. A committee of interested faculty developed the content as well as the local construct and logistics required. Iterative feedback has evolved the duration and content over the initial 3 years. Results: Through formal resident feedback, national subspecialty committee review, and program director meetings the support for the bootcamp has been overwhelmingly positive. Specific resident feedback for structure, content and specific simulations has been favorable, but has also been used to modify the program. Conclusion: In response to identified weaknesses in training, with the support of the national specialty committee, the residency program directors, and the faculty at the University of Toronto, an intensive simulation based thoracic surgery bootcamp has successfully been created for Canadian thoracic surgery residents.

Clinical evaluation of the utility of a flexible 19-gauge EBUS-TBNA needle.
Tomonari Kinoshita, Hideki Ujiie, Joerg Schwock, Kosuke Fujino, Christine McDonald, Chang Young Lee, Alexander Gregor, Chung Chun Tyan, Simon Houston, Kasia Czarnecka-Kujwa, Hisao Asamura, Kazuhiro Yasufuku
Journal of thoracic disease, 10, 4, 2388, 2396, AME PUBL CO, 2018年04月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an established modality for the assessment of mediastinal and hilar adenopathy. To overcome the sampling limitations of standard 21- and 22-gauge EBUS-TBNA needles, a new flexible 19-gauge (Flex 19G) needle was developed. Methods: We performed a retrospective analysis of patients who underwent EBUS-TBNA sampling with the Flex 19G needle. A 22G needle was always used first for cytology, followed by a Flex 19G needle, either an early version (Oct/2014-Sep/2015) or a final version needle (May/2016-Jan/2017), for tissue sampling. The success rate of obtaining samples, specimen quantity, and safety were evaluated and compared. Results: All sampling procedures in 45 patients and 82 targets were performed without complication and the overall diagnostic yield from cytology was 100%. Furthermore, 28% of Flex 19G samples were sufficient for histopathological diagnosis. Yield improved with an increased number of passes and if the target was larger. Compared to the early version evaluated in 52 targets, the final version of the Flex 19G needle evaluated in 30 targets provided significantly larger volume samples and more frequent diagnostic cores. Tissue obtained with the Flex 19G needle retained cohesiveness to a larger degree and was of higher cellularity compared to cytological samples processed as cell blocks. Conclusions: The Flex 19G is safe and provides larger volumetric and cohesive tissue samples that are appropriate for histopathological processing. The final version of the Flex 19G could be a good choice in selected cases where greater tissue acquisition is required.

Targeting non-small cell lung cancer by novel TLD-1433-mediated photodynamic therapy (Conference Presentation)
2018年03月, ［査読有り］

Understanding the possibility of image-guided thermal ablation for pulmonary malignancies.
Hideki Ujiie, Kazuhiro Yasufuku
Journal of thoracic disease, 10, 2, 603, 609, AME PUBL CO, 2018年02月, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）

Personalized siRNA-Nanoparticle Systemic Therapy using Metastatic Lymph Node Specimens Obtained with EBUS-TBNA in Lung Cancer.
Tatsuya Kato, Daiyoon Lee, Huang Huang, William Cruz, Hideki Ujiie, Kosuke Fujino, Hironobu Wada, Priya Patel, Hsin-Pei Hu, Kentaro Hirohashi, Takahiro Nakajima, Masaaki Sato, Mitsuhito Kaji, Kichizo Kaga, Yoshiro Matsui, Juan Chen, Gang Zheng, Kazuhiro Yasufuku
Molecular cancer research : MCR, 16, 1, 47, 57, AMER ASSOC CANCER RESEARCH, 2018年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Inhibiting specific gene expression with siRNA provides a new therapeutic strategy to tackle many diseases at the molecular level. Recent strategies called high-density lipoprotein (HDL)-mimicking peptide-phospholipid nanoscaffold (HPPS) nanoparticles have been used to induce siRNAs-targeted delivery to scavenger receptor class B type I receptor (SCARB1)-expressing cancer cells with high efficiency. Here, eight ideal therapeutic target genes were identified for advanced lung cancer throughout the screenings using endobronchial ultrasonography-guided transbronchial needle aspiration (EBUS-TBNA) and the establishment of a personalized siRNA-nanoparticle therapy. The relevance of these genes was evaluated by means of siRNA experiments in cancer cell growth. To establish a therapeutic model, kinesin family member-11 (KIF11) was selected as a target gene. A total of 356 lung cancers were analyzed immunohistochemically for its clinicopathologic significance. The antitumor effect of HPPS-conjugated siRNA was evaluated in vivo using xenograft tumor models. Inhibition of gene expression for these targets effectively suppressed lung cancer cell growth. SCARB1 was highly expressed in a subset of tumors from the lung large-cell carcinoma (LCC) and small-cell lung cancer (SCLC) patients. High-level KIF11 expression was identified as an independent prognostic factor in LCC and squamous cell carcinoma (SqCC) patients. Finally, a conjugate of siRNA against KIF11 and HPPS nanoparticles induced downregulation of KIF11 expression and mediated dramatic inhibition of tumor growth in vivoImplications: This approach showed delivering personalized cancer-specific siRNAs via the appropriate nanocarrier may be a novel therapeutic option for patients with advanced lung cancer. Mol Cancer Res; 16(1); 47-57. ©2017 AACR.

New era of "resection of the carina and lower trachea".
Hideki Ujiie, Kazuhiro Yasufuku
Journal of thoracic disease, 9, 12, 4932, 4936, AME PUBL CO, 2017年12月, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）

P1.12-002 Nanoparticle Targeted Folate Receptor 1 Enhanced Photodynamic Therapy for Lung Cancer
Hideki Ujiie, MD, PhD
Lung cancer (Amsterdam, Netherlands), 113, 59, 68, 2017年11月, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVE: Despite modest improvements, the prognosis of lung cancer patients has still remained poor and new treatment are urgently needed. Photodynamic therapy (PDT), the use of light-activated compounds (photosensitizers) is a treatment option but its use has been restricted to central airway lesions. Here, we report the use of novel porphyrin-lipid nanoparticles (porphysomes) targeted to folate receptor 1 (FOLR1) to enhance the efficacy and specificity of PDT that may translate into a minimally-invasive intervention for peripheral lung cancer and metastatic lymph nodes of advanced lung cancer. MATERIALS AND METHODS: The frequency of FOLR1 expression in primary lung cancer and metastatic lymph nodes was first analyzed by human tissue samples from surgery and endobronchial ultrasonography-guided transbronchial needle aspiration (EBUS-TBNA). Confocal fluorescence microscopy was then used to confirm the cellular uptake and fluorescence activation in lung cancer cells, and the photocytotoxicity was evaluated using a cell viability assay. In vivo fluorescence activation and quantification of uptake were investigated in mouse lung orthotopic tumor models, followed by the evaluation of in vivo PDT efficacy. RESULTS: FOLR1 was highly expressed in metastatic lymph node samples from patients with advanced lung cancer and was mainly expressed in lung adenocarcinomas in primary lung cancer. Expression of FOLR1 in lung cancer cell lines corresponded with the intracellular uptake of folate-porphysomes in vitro. When irradiated with a 671nm laser at a dose of 10J/cm2, folate-porphysomes showed marked therapeutic efficacy compared with untargeted porphysomes (28% vs. 83% and 24% vs. 99% cell viability in A549 and SBC5 lung cancer cells, respectively). Systemically-administered folate-porphysomes accumulated in lung tumors with significantly enhanced disease-to-normal tissue contrast. Folate-porphysomes mediated PDT successfully inhibited tumor cell proliferation and activated tumor cell apoptosis. CONCLUSION: Folate-porphysome based PDT shows promise in selectively ablating lung cancer based on FOLR1 expression in these preclinical models.

Nanoparticle targeted folate receptor 1-enhanced photodynamic therapy for lung cancer.
Tatsuya Kato, Cheng S Jin, Hideki Ujiie, Daiyoon Lee, Kosuke Fujino, Hironobu Wada, Hsin-Pei Hu, Robert A Weersink, Juan Chen, Mitsuhito Kaji, Kichizo Kaga, Yoshiro Matsui, Brian C Wilson, Gang Zheng, Kazuhiro Yasufuku
Lung cancer (Amsterdam, Netherlands), 113, 59, 68, ELSEVIER IRELAND LTD, 2017年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVE: Despite modest improvements, the prognosis of lung cancer patients has still remained poor and new treatment are urgently needed. Photodynamic therapy (PDT), the use of light-activated compounds (photosensitizers) is a treatment option but its use has been restricted to central airway lesions. Here, we report the use of novel porphyrin-lipid nanoparticles (porphysomes) targeted to folate receptor 1 (FOLR1) to enhance the efficacy and specificity of PDT that may translate into a minimally-invasive intervention for peripheral lung cancer and metastatic lymph nodes of advanced lung cancer. MATERIALS AND METHODS: The frequency of FOLR1 expression in primary lung cancer and metastatic lymph nodes was first analyzed by human tissue samples from surgery and endobronchial ultrasonography-guided transbronchial needle aspiration (EBUS-TBNA). Confocal fluorescence microscopy was then used to confirm the cellular uptake and fluorescence activation in lung cancer cells, and the photocytotoxicity was evaluated using a cell viability assay. In vivo fluorescence activation and quantification of uptake were investigated in mouse lung orthotopic tumor models, followed by the evaluation of in vivo PDT efficacy. RESULTS: FOLR1 was highly expressed in metastatic lymph node samples from patients with advanced lung cancer and was mainly expressed in lung adenocarcinomas in primary lung cancer. Expression of FOLR1 in lung cancer cell lines corresponded with the intracellular uptake of folate-porphysomes in vitro. When irradiated with a 671nm laser at a dose of 10J/cm2, folate-porphysomes showed marked therapeutic efficacy compared with untargeted porphysomes (28% vs. 83% and 24% vs. 99% cell viability in A549 and SBC5 lung cancer cells, respectively). Systemically-administered folate-porphysomes accumulated in lung tumors with significantly enhanced disease-to-normal tissue contrast. Folate-porphysomes mediated PDT successfully inhibited tumor cell proliferation and activated tumor cell apoptosis. CONCLUSION: Folate-porphysome based PDT shows promise in selectively ablating lung cancer based on FOLR1 expression in these preclinical models.

Image-guided localization and minimally invasive resection of small pulmonary nodules using near-infrared (NIR) thoracoscope and indocyanine green (ICG) fluorescence in the guided therapeutics (GTx) OR
Hideki Ujiie, Andrew Effat, Kazuhiro Yasufuku
ASVIDE, 2017年10月, ［査読有り］, ［筆頭著者］
英語, 研究論文（学術雑誌）

Human Ex Vivo Lung Evaluation of the Next Generation Convex Probe Endobronchial Ultrasound Bronchoscope
Kosuke Fujino, Hideki Ujiie, Hitoshi Igai, Tomonari Kinoshita, Changyoung Lee, Salma Hindy, Andrew Effat, Kazuhiro Yasufuku
CHEST, 152, 4, 884A, 884A, ELSEVIER SCIENCE BV, 2017年10月, ［査読有り］
英語, 研究論文（学術雑誌）

Clinical Utility of Flexible 19G EBUS-TBNA Needle
Tomonari Kinoshita, Hideki Ujiie, Kosuke Fujino, Hitoshi Igai, Christina McDonald, Changyoung Lee, Chung Chun Tyan, Simon Houston, Kasia Czarnecka-Kujwa, Kazuhiro Yasufuku
CHEST, 152, 4, 967A, 967A, ELSEVIER SCIENCE BV, 2017年10月, ［査読有り］
英語, 研究論文（学術雑誌）

A novel minimally invasive near-infrared thoracoscopic localization technique of small pulmonary nodules: A phase I feasibility trial.
Hideki Ujiie, Tatsuya Kato, Hsin-Pei Hu, Priya Patel, Hironobu Wada, Kosuke Fujino, Robert Weersink, Elsie Nguyen, Marcelo Cypel, Andrew Pierre, Marc de Perrot, Gail Darling, Thomas K Waddell, Shaf Keshavjee, Kazuhiro Yasufuku
The Journal of thoracic and cardiovascular surgery, 154, 2, 702, 711, MOSBY-ELSEVIER, 2017年08月, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVES: Localization and resection of nonvisible, nonpalpable pulmonary nodules during video-assisted thoracoscopic surgery are challenging. Our study was to determine the feasibility and safety of indocyanine green fluorescence localization and resection of small nodules using a near-infrared fluorescence thoracoscope. METHODS: Twenty patients with undiagnosed peripheral nodules smaller than 3 cm scheduled for computed tomography-guided microcoil placement followed by video-assisted thoracoscopic surgery wedge resection were enrolled. After microcoil deployment, 100 to 150 μL of diluted indocyanine green was injected percutaneously near the nodule. The nodule initially was localized solely by using a near-infrared thoracoscope to visualize indocyanine green fluorescence. Thoracoscopic instruments were used to determine the staple line. Wedge resection was performed after confirmation of the location of the microcoil using fluoroscopy. RESULTS: Twenty patients underwent near-infrared, image-guided, video-assisted thoracoscopic surgery resection. The median computed tomography tumor size was 1.2 cm. The median depth from the pleural surface was 1.4 cm (range, 0.2-4.8 cm). The median computed tomography-guided intervention time was 35 minutes, and video-assisted thoracoscopic surgery procedural time was 54 minutes. Indocyanine green fluorescence was clearly identified in 18 of 20 patients (90%). The surgical margins were all negative on final pathology without the need for additional resection. The final diagnoses included 18 primary lung cancers, 1 metastatic lung cancer, and 1 benign lung tumor. CONCLUSIONS: Computed tomography-guided percutaneous indocyanine green injection and intraoperative near-infrared localization of small nodules are safe and feasible. These offer surgeons the ease of localization through direct indocyanine green fluorescence imaging without the use of fluoroscopy and may be a complementary technique to preoperative microcoil placement for nonvisible, nonpalpable intrapulmonary nodules.

The importance of novel molecular biomarker of early stage lung adenocarcinoma
Hideki Ujiie, Kazuhiro Yasufuku
TRANSLATIONAL CANCER RESEARCH, 6, S964, S968, AME PUBL CO, 2017年08月, ［査読有り］
英語, 研究論文（学術雑誌）

The importance of novel molecular biomarker of early stage lung adenocarcinoma
Hideki Ujiie, MD, PhD
2017年08月, ［査読有り］
研究論文（学術雑誌）

Overexpression of MAGEA2 has a prognostic significance and is a potential therapeutic target for patients with lung cancer.
Hideki Ujiie, Tatsuya Kato, Daiyoon Lee, Hsin-Pei Hu, Kosuke Fujino, Mitsuhito Kaji, Kichizo Kaga, Yoshiro Matsui, Kazuhiro Yasufuku
International journal of oncology, 50, 6, 2154, 2170, SPANDIDOS PUBL LTD, 2017年06月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Melanoma-associated antigens (MAGE) are expressed in different type of cancers including lung cancer and have been shown to be functionally related to p53 tumor suppressor gene. Little is known about the relationship between MAGE genes and p53 aberrant expression in lung cancer. The aims of this study were to observe the expression of MAGEA2, examine the role of MAGEA2 in lung cancer survival, investigate its correlation between MAGEA2 and p53, and explore its clinicopathologic significance as a prognostic marker. Quantitative reverse transcription-polymerase chain reaction was performed to detect the expression of MAGEA2 using 36 primary tumors and 31 metastatic lymph nodes from patients with lung cancer. The role of MAGEA2 in cancer cell growth and in the regulation of p53 downstream genes were examined using small interfering RNA. The expression of MAGEA2 and p53 were analyzed immunohistochemically using tissue microarray from 353 resected lung specimens. High-level expression of MAGEA2 (High-MAGEA2) was confirmed in lung tumors with high frequency. Inhibiting MAGEA2 expression effectively suppressed cancer cell growth and decreased the expression of p53 downstream target genes in vitro. In adenocarcinoma, High-MAGEA2 was strongly associated with aberrant p53 expression (P<0.001) and was associated with worse clinical outcomes (5-year OS, 87.1% in low vs. 74.1% in high, P=0.014). Aberrant p53 expression was also significant worse prognostic factor (P=0.029). Among the adenocarcinoma patients with wild-type p53, High-MAGEA2 had poorer prognosis than low-level MAGEA2 groups (5-year OS, 90.1% vs. 72.1%, P=0.037), whereas had no difference in p53 aberrant tumors. On multivariate analysis, MAGEA2 was independently associated with survival (hazard ratio; 2.12, P=0.030). In conclusion, suppression of MAGEA2 in lung cancer cells significantly reduced the growth/survival of cancer cells. High-MAGEA2 was identified as an independent prognostic factor in lung adenocarcinoma. Specific inhibition of MAGEA2 may be a promising therapeutic strategy for patients with lung cancer.

Development of a novel ex vivo porcine laparoscopic Heller myotomy and Nissen fundoplication training model (Toronto lap-Nissen simulator).
Hideki Ujiie, Tatsuya Kato, Hsin-Pei Hu, Patrycja Bauer, Priya Patel, Hironobu Wada, Daiyoon Lee, Kosuke Fujino, Colin Schieman, Andrew Pierre, Thomas K Waddell, Shaf Keshavjee, Gail E Darling, Kazuhiro Yasufuku
Journal of thoracic disease, 9, 6, 1517, 1524, AME PUBL CO, 2017年06月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Surgical trainees are required to develop competency in a variety of laparoscopic operations. Developing laparoscopic technical skills can be difficult as there has been a decrease in the number of procedures performed. This study aims to develop an inexpensive and anatomically relevant model for training in laparoscopic foregut procedures. METHODS: An ex vivo, anatomic model of the human upper abdomen was developed using intact porcine esophagus, stomach, diaphragm and spleen. The Toronto lap-Nissen simulator was contained in a laparoscopic box-trainer and included an arch system to simulate the normal radial shape and tension of the diaphragm. We integrated the use of this training model as a part of our laparoscopic skills laboratory-training curriculum. Afterwards, we surveyed trainees to evaluate the observed benefit of the learning session. RESULTS: Twenty-five trainees and five faculty members completed a survey regarding the use of this model. Among the trainees, only 4 (16%) had experience with laparoscopic Heller myotomy and Nissen fundoplication. They reported that practicing with the model was a valuable use of their limited time, repeating the exercise would be of additional benefit, and that the exercise improved their ability to perform or assist in an actual case in the operating room. Significant improvements were found in the following subjective measures comparing pre- vs. post-training: (I) knowledge level (5.6 vs. 8.0, P<0.001); (II) comfort level in assisting (6.3 vs. 7.6, P<0.001); and (III) comfort level in performing as the primary surgeon (4.9 vs. 7.1, P<0.001). The trainees and faculty members agreed that this model was of adequate fidelity and was a representative simulation of actual human anatomy. CONCLUSIONS: We developed an easily reproducible training model for laparoscopic procedures. This simulator reproduces human anatomy and increases the trainees' comfort level in performing and assisting with myotomy and fundoplication.

First Evaluation of the New Thin Convex Probe Endobronchial Ultrasound Scope: A Human Ex Vivo Lung Study.
Patel P, Wada H, Hu HP, Hirohashi K, Kato T, Ujiie H, Ahn JY, Lee D, Geddie W, Yasufuku K
The Annals of thoracic surgery, 103, 4, 1158, 1164, ELSEVIER SCIENCE INC, 2017年04月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Endobronchial ultrasonography (EBUS)-guided transbronchial needle aspiration allows for sampling of mediastinal lymph nodes. The external diameter, rigidity, and angulation of the convex probe EBUS renders limited accessibility. This study compares the accessibility and transbronchial needle aspiration capability of the prototype thin convex probe EBUS against the convex probe EBUS in human ex vivo lungs rejected for transplant.The prototype thin convex probe EBUS (BF-Y0055; Olympus, Tokyo, Japan) with a thinner tip (5.9 mm), greater upward angle (170 degrees), and decreased forward oblique direction of view (20 degrees) was compared with the current convex probe EBUS (6.9-mm tip, 120 degrees, and 35 degrees, respectively). Accessibility and transbronchial needle aspiration capability was assessed in ex vivo human lungs declined for lung transplant. The distance of maximum reach and sustainable endoscopic limit were measured. Transbronchial needle aspiration capability was assessed using the prototype 25G aspiration needle in segmental lymph nodes.In all evaluated lungs (n = 5), the thin convex probe EBUS demonstrated greater reach and a higher success rate, averaging 22.1 mm greater maximum reach and 10.3 mm further endoscopic visibility range than convex probe EBUS, and could assess selectively almost all segmental bronchi (98% right, 91% left), demonstrating nearly twice the accessibility as the convex probe EBUS (48% right, 47% left). The prototype successfully enabled cytologic assessment of subsegmental lymph nodes with adequate quality using the dedicated 25G aspiration needle.Thin convex probe EBUS has greater accessibility to peripheral airways in human lungs and is capable of sampling segmental lymph nodes using the aspiration needle. That will allow for more precise assessment of N1 nodes and, possibly, intrapulmonary lesions normally inaccessible to the conventional convex probe EBUS.

Evaluation of a New Ultrasound Thoracoscope for Localization of Lung Nodules in Ex Vivo Human Lungs.
Ujiie H, Kato T, Hu HP, Hasan S, Patel P, Wada H, Lee D, Fujino K, Hwang DM, Cypel M, de Perrot M, Pierre A, Darling G, Waddell TK, Keshavjee S, Yasufuku K
The Annals of thoracic surgery, 103, 3, 926, 934, ELSEVIER SCIENCE INC, 2017年03月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Localization of small, nonvisible and nonpalpable nodules is challenging during video-assisted thoracoscopic surgery. We evaluated the feasibility of using a new ultrasound thoracoscope to localize nodules in resected ex vivo human lungs.The tumor was localized and measured in its greatest dimension with a prototype ultrasound thoracoscope (XLTF-UC180; Olympus Corporation, Tokyo, Japan) at different frequencies (5.0 to 12.0 MHz) and different lung specimen states (deflated, semiinflated). Measured tumor size and depth from lung surface were compared and correlated to the true diameter and depth from lung surface acquired from pathologic morphology.Ex vivo evaluation was performed on 16 solid nodules and nine part solid ground-glass nodules. All tumors were successfully localized in the deflated lung specimens (average size, 13.7 ± 5.2 mm). The tumor boundaries were best evaluated with an ultrasound frequency of 10 MHz. Solid nodules were more easily visualized than ground-glass nodules. Part solid ground-glass nodules were not easily detected in the semiinflated specimen owing to peritumoral air surrounding the tumor. Tumor boundaries were also difficult to identify in deeply situated tumors and in lungs with underlying disease. A strong positive correlation existed between the ultrasound measurement and true measurement of tumor size (R2 = 0.89, p < 0.001).The ultrasound thoracoscope can be used to localize nodules in resected human lungs. The clarity of the tumor boundaries is influenced by the tumor type and depth and the underlying pulmonary disease. Complete lung deflation and the use of 10 MHz ultrasound frequency optimize the visualization of target tumors.

Gene signature
Hideki Ujiie, Daiyoon Lee, Tatsuya Kato, Kazuhiro Yasufuku
Molecular Targeted Therapy of Lung Cancer, 279, 292, 2017年01月01日, ［査読有り］
論文集(書籍)内論文, © Springer Science+Business Media Singapore 2017. In the past decade, there has been seen an increase in the number of cancer therapies that aim to circumscribe the spread and expansion of primary and metastatic tumors. A common characteristic among these therapies is their ability to target cancer progression via different pathways, which is fundamental to preventing successful tumor spreading and dissemination. Recent advancements in gene expression profiling have been fundamental in the identification of new cancer targets, and, consequently, improved targeted therapies have emerged as gene expression arrays, and DNA sequencing have enhanced our understanding of cancer genetics. Modern tumor pathology is now understood and studied at the molecular level ranging from immunohistochemistry (IHC) biomarkers to gene signature classifications and gene mutations, all of which provide significant knowledge about which patients will respond to targeted therapy regimens. We briefly discuss the common types of targeted therapies currently used clinically and provide a brief background on IHC, gene expression, and DNA sequencing technologies. We further provide a discussion on guided therapies and also focus on the appropriate targeted therapies and the pathways they inhibit. A number of prognostic gene expression signatures have been reported to predict survival in non-small cell lung cancer (NSCLC). We focus on the role of gene expression profiling in NSCLC as predictive and prognostic biomarker and its potential use for personalized therapy in the years to come.

Image-guided thoracic surgery in the hybrid operation room.
Hideki Ujiie, Andrew Effat, Kazuhiro Yasufuku
Journal of visualized surgery, 3, 148, 148, 2017年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, There has been an increase in the use of image-guided technology to facilitate minimally invasive therapy. The next generation of minimally invasive therapy is focused on advancement and translation of novel image-guided technologies in therapeutic interventions, including surgery, interventional pulmonology, radiation therapy, and interventional laser therapy. To establish the efficacy of different minimally invasive therapies, we have developed a hybrid operating room, known as the guided therapeutics operating room (GTx OR) at the Toronto General Hospital. The GTx OR is equipped with multi-modality image-guidance systems, which features a dual source-dual energy computed tomography (CT) scanner, a robotic cone-beam CT (CBCT)/fluoroscopy, high-performance endobronchial ultrasound system, endoscopic surgery system, near-infrared (NIR) fluorescence imaging system, and navigation tracking systems. The novel multimodality image-guidance systems allow physicians to quickly, and accurately image patients while they are on the operating table. This yield improved outcomes since physicians are able to use image guidance during their procedures, and carry out innovative multi-modality therapeutics. Multiple preclinical translational studies pertaining to innovative minimally invasive technology is being developed in our guided therapeutics laboratory (GTx Lab). The GTx Lab is equipped with similar technology, and multimodality image-guidance systems as the GTx OR, and acts as an appropriate platform for translation of research into human clinical trials. Through the GTx Lab, we are able to perform basic research, such as the development of image-guided technologies, preclinical model testing, as well as preclinical imaging, and then translate that research into the GTx OR. This OR allows for the utilization of new technologies in cancer therapy, including molecular imaging, and other innovative imaging modalities, and therefore enables a better quality of life for patients, both during and after the procedure. In this article, we describe capabilities of the GTx systems, and discuss the first-in-human technologies used, and evaluated in GTx OR.

SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma.
Tatsuya Kato, Daiyoon Lee, Licun Wu, Priya Patel, Ahn Jin Young, Hironobu Wada, Hsin-Pei Hu, Hideki Ujiie, Mitsuhito Kaji, Satoshi Kano, Shinichi Matsuge, Hiromitsu Domen, Hiromi Kanno, Yutaka Hatanaka, Kanako C Hatanaka, Kichizo Kaga, Yoshiro Matsui, Yoshihiro Matsuno, Marc De Perrot, Kazuhiro Yasufuku
International journal of oncology, 49, 6, 2411, 2420, SPANDIDOS PUBL LTD, 2016年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Malignant pleural mesothelioma (MPM) is an aggressive type of cancer of the thoracic cavity commonly associated with asbestos exposure and a high mortality rate. There is a need for new molecular targets for the development of more effective therapies for MPM. Using quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) and an RNA interference-based screening, we examined the SORORIN gene as potential therapeutic targets for MPM in addition to the PLK1 gene, which is known for kinase of SORORIN. Following in vitro investigation of the effects of target silencing on MPM cells, cell cycle analyses were performed. SORORIN expression was analyzed immunohistochemically using a total of 53 MPM samples on tissue microarray. SORORIN was found to be overexpressed in the majority of clinical MPM samples and human MPM cell lines as determined by qRT-PCR. Gene suppression of each SORORIN and PLK1 led to growth inhibition in MPM cell lines. Knockdown of SORORIN showed an increased number of G2M-phase population and a larger nuclear size, suggesting mitotic arrest. High expression of SORORIN (SORORIN-H) was found in 50.9% of all the MPM cases, and there is a tendency towards poorer prognosis for the SORORIN-H group but the difference is not significant. Suppression of SORORIN with PLK1 inhibitor BI 6727 showed a combinational growth suppressive effect on MPM cell growth. Given high-dose PLK1 inhibitor induced drug-related adverse effects in several clinical trials, our results suggest inhibition SORORIN-PLK1 axis may hold promise for the treatment of MPMs.

Validating Spectrum Image Analysis of Lymph Nodes During Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Patients With Lung Cancer
Hideki Ujiie, Takahiro Nakajima, Hsin-pei Hu, Kosuke Fujino, Tatsuya Kato, Kazuhiro Yasufuku
CHEST, 150, 4, 1045A, 1045A, AMER COLL CHEST PHYSICIANS, 2016年10月, ［査読有り］, ［筆頭著者］
英語, 研究論文（学術雑誌）

Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma.
Tatsuya Kato, Daiyoon Lee, Licun Wu, Priya Patel, Ahn Jin Young, Hironobu Wada, Hsin-Pei Hu, Hideki Ujiie, Mitsuhito Kaji, Satoshi Kano, Shinichi Matsuge, Hiromitsu Domen, Kichizo Kaga, Yoshiro Matsui, Hiromi Kanno, Yutaka Hatanaka, Kanako C Hatanaka, Yoshihiro Matsuno, Marc de Perrot, Kazuhiro Yasufuku
International journal of oncology, 49, 2, 448, 56, SPANDIDOS PUBL LTD, 2016年08月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer commonly associated with asbestos exposure that stems from the thoracic mesothelium with high mortality rate. Currently, treatment options for MPM are limited, and new molecular targets for treatments are urgently needed. Using quantitative reverse transcription-polymerase chain reaction (RT-PCR) and an RNA interference-based screening, we screened two kinesin family members as potential therapeutic targets for MPM. Following in vitro investigation of the target silencing effects on MPM cells, a total of 53 MPMs were analyzed immunohistochemically with tissue microarray. KIF11 and KIF23 transcripts were found to be overexpressed in the majority of clinical MPM samples as well as human MPM cell lines as determined by quantitative RT-PCR. Gene knockdown in MPM cell lines identified growth inhibition following knockdown of KIF11 and KIF23. High expression of KIF11 (KIF11-H) and KIF23 (KIF23-H) were found in 43.4 and 50.9% of all the MPM cases, respectively. Patients who received curative resection with tumors displaying KIF23-H showed shorter overall survival (P=0.0194). These results provide that inhibition of KIF11 and KIF23 may hold promise for treatment of MPMs, raising the possibility that kinesin-based drug targets may be developed in the future.

Overexpression of KIF23 predicts clinical outcome in primary lung cancer patients.
Tatsuya Kato, Hironobu Wada, Priya Patel, Hsin-Pei Hu, Daiyoon Lee, Hideki Ujiie, Kentaro Hirohashi, Takahiro Nakajima, Masaaki Sato, Mitsuhito Kaji, Kichizo Kaga, Yoshiro Matsui, Ming-Sound Tsao, Kazuhiro Yasufuku
Lung cancer (Amsterdam, Netherlands), 92, 53, 61, ELSEVIER IRELAND LTD, 2016年02月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVE: High-level expression of kinesin family member 23 (KIF23), a member of microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division, has been observed in a variety of human malignancies. The aims of the present study were to observe the expression of KIF23 in lung cancer, examine the role of KIF23 in lung cancer cell growth and/or survival by small interfering RNA experiments, and explore its clinicopathologic significance and evaluate KIF23 expression as a prognostic marker. MATERIALS AND METHODS: Quantitative reverse transcription-polymerase chain reaction analysis was performed to detect the expression of KIF23 mRNA using metastatic lymph nodes from patients with advanced lung cancer obtained by endobronchial ultrasonography-guided transbronchial needle aspiration (EBUS-TBNA) and primary lung tumors through surgical sample. The role of KIF23 in cancer cell growth was examined by small interfering RNA experiments. A total of 339 lung cancers were analyzed immunohistochemically on tissue microarrays to examine the expression of KIF23 protein and its clinicopathologic significance. RESULTS: KIF23 transcript was found to be overexpressed in the great majority of metastatic lymph nodes from advanced lung cancers and primary lung tumors. Inhibiting KIF23 expression effectively suppressed lung cancer cell growth. High-level KIF23 expression was observed in 67.8% of the 339 cases. Lung adenocarcinoma patients with tumors displaying a high-level of KIF23 expression was also identified as an independent prognostic factor by multivariate analysis (P=0.0064). CONCLUSION: KIF23 not only provides additional prognostic information for surgical treatment of lung cancer, but may also be a novel therapeutic target for these patients.

Multi-Modal Imaging in a Mouse Model of Orthotopic Lung Cancer.
Priya Patel, Tatsuya Kato, Hideki Ujiie, Hironobu Wada, Daiyoon Lee, Hsin-Pei Hu, Kentaro Hirohashi, Jin Young Ahn, Jinzi Zheng, Kazuhiro Yasufuku
PloS one, 11, 9, e0161991, PUBLIC LIBRARY SCIENCE, 2016年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Investigation of CF800, a novel PEGylated nano-liposomal imaging agent containing indocyanine green (ICG) and iohexol, for real-time near infrared (NIR) fluorescence and computed tomography (CT) image-guided surgery in an orthotopic lung cancer model in nude mice. METHODS: CF800 was intravenously administered into 13 mice bearing the H460 orthotopic human lung cancer. At 48 h post-injection (peak imaging agent accumulation time point), ex vivo NIR and CT imaging was performed. A clinical NIR imaging system (SPY®, Novadaq) was used to measure fluorescence intensity of tumor and lung. Tumor-to-background-ratios (TBR) were calculated in inflated and deflated states. The mean Hounsfield unit (HU) of lung tumor was quantified using the CT data set and a semi-automated threshold-based method. Histological evaluation using H&E, the macrophage marker F4/80 and the endothelial cell marker CD31, was performed, and compared to the liposomal fluorescence signal obtained from adjacent tissue sections. RESULTS: The fluorescence TBR measured when the lung is in the inflated state (2.0 ± 0.58) was significantly greater than in the deflated state (1.42 ± 0.380 (n = 7, p<0.003). Mean fluorescent signal in tumor was highly variable across samples, (49.0 ± 18.8 AU). CT image analysis revealed greater contrast enhancement in lung tumors (a mean increase of 110 ± 57 HU) when CF800 is administered compared to the no contrast enhanced tumors (p = 0.0002). CONCLUSION: Preliminary data suggests that the high fluorescence TBR and CT tumor contrast enhancement provided by CF800 may have clinical utility in localization of lung cancer during CT and NIR image-guided surgery.

Solid Predominant Histologic Subtype in Resected Stage I Lung Adenocarcinoma Is an Independent Predictor of Early, Extrathoracic, Multisite Recurrence and of Poor Postrecurrence Survival.
Hideki Ujiie, Kyuichi Kadota, Jamie E Chaft, Daniel Buitrago, Camelia S Sima, Ming-Ching Lee, James Huang, William D Travis, Nabil P Rizk, Charles M Rudin, David R Jones, Prasad S Adusumilli
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33, 26, 2877, 84, AMER SOC CLINICAL ONCOLOGY, 2015年09月10日, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: To examine the significance of the proposed International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society (IASLC/ATS/ERS) histologic subtypes of lung adenocarcinoma for patterns of recurrence and, among patients who recur following resection of stage I lung adenocarcinoma, for postrecurrence survival (PRS). PATIENTS AND METHODS: We reviewed patients with stage I lung adenocarcinoma who had undergone complete surgical resection from 1999 to 2009 (N = 1,120). Tumors were subtyped by using the IASLC/ATS/ERS classification. The effects of the dominant subtype on recurrence and, among patients who recurred, on PRS were investigated. RESULTS: Of 1,120 patients identified, 188 had recurrent disease, 103 of whom died as a result of lung cancer. Among patients who recurred, 2-year PRS was 45%, and median PRS was 26.1 months. Compared with patients with nonsolid tumors, patients with solid predominant tumors had earlier (P = .007), more extrathoracic (P < .001), and more multisite (P = .011) recurrences. Multivariable analysis of primary tumor factors revealed that, among patients who recurred, solid predominant histologic pattern in the primary tumor (hazard ratio [HR], 1.76; P = .016), age older than 65 years (HR, 1.63; P = .01), and sublobar resection (HR, 1.6; P = .01) were significantly associated with worse PRS. Presence of extrathoracic metastasis (HR, 1.76; P = .013) and age older than 65 years at the time of recurrence (HR, 1.7; P = .014) were also significantly associated with worse PRS. CONCLUSION: In patients with stage I primary lung adenocarcinoma, solid predominant subtype is an independent predictor of early recurrence and, among those patients who recur, of worse PRS. Our findings provide a rationale for investigating adjuvant therapy and identify novel therapeutic targets for patients with solid predominant lung adenocarcinoma.

Mesothelin and MUC16 (CA125) Are Antigen-Targets for CAR T-Cell Therapy in Primary and Metastatic Lung Adenocarcinoma
Takashi Eguchi, Hideki Ujiie, Aurore Morello, Kyuichi Kadota, Daniel H. Buitrago, Kaitlin Woo, David R. Jones, William D. Travis, Michel Sadelain, Prasad S. Adusumilli
JOURNAL OF THORACIC ONCOLOGY, 10, 9, S229, S229, ELSEVIER SCIENCE INC, 2015年09月, ［査読有り］
英語

Targetable Cancer-Associated Antigens for Immunotherapy in Malignant Pleural Mesothelioma (MPM) - Mesothelin, CA125 and WT-1
Hideki Ujiie, Takashi Eguchi, Marissa Mayor, Kyuichi Kadota, William D. Travis, David R. Jones, Michel Sadelain, Prasad S. Adusumilli
JOURNAL OF THORACIC ONCOLOGY, 10, 9, S755, S756, ELSEVIER SCIENCE INC, 2015年09月, ［査読有り］, ［筆頭著者］
英語

Prognostic Impact of Immune Microenvironment in Lung Squamous Cell Carcinoma: Tumor-Infiltrating CD10+ Neutrophil/CD20+ Lymphocyte Ratio as an Independent Prognostic Factor.
Kyuichi Kadota, Jun-Ichi Nitadori, Hideki Ujiie, Daniel H Buitrago, Kaitlin M Woo, Camelia S Sima, William D Travis, David R Jones, Prasad S Adusumilli
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 10, 9, 1301, 1310, ELSEVIER SCIENCE INC, 2015年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, INTRODUCTION: We previously reported the prognostic significance of the lung adenocarcinoma immune microenvironment. In this study, we preformed comprehensive analysis of immune markers and their associations with prognosis in patients with lung squamous cell carcinoma. METHODS: We reviewed surgically resected, solitary lung squamous cell carcinoma patients (n = 485; 1999-2009) who were randomly split into a training cohort (n = 331) and validation cohort (n = 154). We constructed tissue microarrays and performed immunostaining for CD3, CD45RO, CD8, CD4, FoxP3, CD20, CD68, CXCL12, CXCR4, CCR7, interleukin-7 receptor, and interleukin-12 receptor β2. Overall survival (OS) was analyzed using the log-rank test and the Cox proportional hazards model. RESULTS: Analysis of single immune cell infiltration revealed that high tumor-infiltrating CD10(+) neutrophils were associated with worse prognoses in the training cohort (p = 0.021). Analysis of biologically relevant immune cell combinations identified that patients with high CD10 neutrophil and low CD20(+) lymphocyte had a significantly worse OS (5-year OS, 42%) than those with other combinations of CD10 and CD20 (5-year OS, 62%; p < 0.001); this was confirmed in the validation cohort (p = 0.032). For the multivariate analysis, high CD10/low CD20 immune cell infiltration was an independent predictor of OS in both the training cohort (hazard ratio = 1.61, p = 0.006) and the validation cohort (hazard ratio = 1.75; p = 0.043). CONCLUSION: High CD10(+)/low CD20(+) immune cell infiltration ratio is a significant prognostic factor of lung squamous cell carcinoma. Immunomodulatory therapy of tumor-specific neutrophil and B-lymphocyte responses may have applicability in the treatment of lung squamous cell carcinoma.

The tumoral and stromal immune microenvironment in malignant pleural mesothelioma: A comprehensive analysis reveals prognostic immune markers.
Hideki Ujiie, Kyuichi Kadota, Jun-Ichi Nitadori, Joachim G Aerts, Kaitlin M Woo, Camelia S Sima, William D Travis, David R Jones, Lee M Krug, Prasad S Adusumilli
Oncoimmunology, 4, 6, e1009285, TAYLOR & FRANCIS INC, 2015年06月, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, Antitumor immune responses against solid malignancies correlate with improved patient survival. We conducted a comprehensive investigation of immune responses in tumor and tumor-associated stroma in epithelioid malignant pleural mesothelioma with the goal of characterizing the tumor immune microenvironment and identifying prognostic immune markers. We investigated 8 types of tumor-infiltrating immune cells within the tumor nest and tumor-associated stroma, as well as tumor expression of 5 cytokine/chemokine receptors in 230 patients. According to univariate analyses, high densities of tumoral CD4- and CD20-expressing lymphocytes were associated with better outcomes. High expression of tumor interleukin-7 (IL-7) receptor was associated with worse outcomes. According to multivariate analyses, stage and tumoral CD20 detection were independently associated with survival. Analysis of single immune cell infiltration for CD163+ tumor-associated macrophages did not correlate with survival. However, analysis of immunologically relevant cell combinations identified that: (1) high CD163+ tumor-associated macrophages and low CD8+ lymphocyte infiltration had worse prognosis than other groups and (2) low CD163+ tumor associated macrophages and high CD20+ lymphocyte infiltration had better prognosis than other groups. Multivariate analyses demonstrated that CD163/CD8 and CD163/CD20 were independent prognostic factors of survival. With a recent increase in immunotherapy investigations and clinical trials for malignant pleural mesothelioma patients, our observations that CD20+ B lymphocytes and tumor-associated macrophages are prognostic markers provide important information about the tumor microenvironment of malignant pleural mesothelioma.

Tumor Spread through Air Spaces is an Important Pattern of Invasion and Impacts the Frequency and Location of Recurrences after Limited Resection for Small Stage I Lung Adenocarcinomas.
Kyuichi Kadota, Jun-Ichi Nitadori, Camelia S Sima, Hideki Ujiie, Nabil P Rizk, David R Jones, Prasad S Adusumilli, William D Travis
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 10, 5, 806, 814, ELSEVIER SCIENCE INC, 2015年05月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, INTRODUCTION: Tumor invasion in lung adenocarcinoma is defined as infiltration of stroma, blood vessels, or pleura. Based on observation of tumor spread through air spaces (STAS), we considered whether this could represent new patterns of invasion and investigated whether it correlated with locoregional versus distant recurrence according to limited resection versus lobectomy. METHODS: We reviewed resected small (less than or equal to 2 cm) stage I lung adenocarcinomas (n = 411; 1995-2006). Tumor STAS was defined as tumor cells-micropapillary structures, solid nests, or single cells-spreading within air spaces in the lung parenchyma beyond the edge of the main tumor. Competing risks methods were used to estimate risk of disease recurrence and its associations with clinicopathological risk factors. RESULTS: STAS was observed in 155 cases (38%). In the limited resection group (n = 120), the risk of any recurrence was significantly higher in patients with STAS-positive tumors than that of patients with STAS-negative tumors (5-year cumulative incidence of recurrence, 42.6% versus 10.9%; P < 0.001); the presence of STAS correlated with higher risk of distant (P = 0.035) and locoregional recurrence (P = 0.001). However, in the lobectomy group (n = 291), the presence of STAS was not associated with either any (P = 0.50) or distant recurrence (P = 0.76). In a multivariate analysis, the presence of tumor STAS remained independently associated with the risk of developing recurrence (hazard ratio, 3.08; P = 0.014). CONCLUSION: The presence of STAS is a significant risk factor of recurrence in small lung adenocarcinomas treated with limited resection. These findings support our proposal that STAS should formally be recognized as a pattern of invasion in lung adenocarcinoma.

The tumor immune microenvironment in octogenarians with stage I non-small cell lung cancer.
Ming-Ching Lee, Daniel H Buitrago, Kyuichi Kadota, Hideki Ujiie, Kaitlin Woo, Camelia S Sima, William D Travis, David R Jones, Prasad S Adusumilli
Oncoimmunology, 3, 11, e967142, 1, 2014年11月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality and has increasingly become a disease of elderly patients. Elderly patients are underrepresented in clinical trials that evaluate treatments for NSCLC. It has been suggested that patients >65 years of age have less robust immune responses to infections, immunizations, and tumors compared with younger patients. With increasing focus and number of immunotherapy clinical trials for NSCLC, we investigated the relationship between patient age and the tumor immune microenvironment in NSCLC. Using tissue microarrays from 1,278 patients with surgically resected Stage I NSCLC (≤65 years [33%], 66-79 years [55%], and ≥80 years [12%]), we determined whether quantitative and qualitative immune cell infiltration in the tumor differed between younger and older patients. Furthermore, we investigated the prognostic value of immune cell infiltration with respect to recurrence in octogenarians. We found that there were no statistically significant differences between older and younger patients in tumoral immune infiltration or effector regulatory immune response ratios (FoxP3/CD3, FoxP3/CD4, and FoxP3/CD8 ratios). In octogenarians, presence of low tumoral CD68+ immune cells was an independent predictor of recurrence. In the uniform cohort of surgically selected and resected Stage I NSCLC patients, tumor immune cell infiltration among the older age group resembled other age groups. Our study provides information that supports inclusion of older age patients selected for surgical resection in neoadjuvant or adjuvant immunotherapy clinical trials for lung cancer.

The tumor immune microenvironment in octogenarians with stage I non-small cell lung cancer
Ming-Ching Lee, Daniel H. Buitrago, Kyuichi Kadota, Hideki Ujiie, Kaitlin Woo, Camelia S. Sima, William D. Travis, David R. Jones, Prasad S. Adusumilli
ONCOIMMUNOLOGY, 3, 11, TAYLOR & FRANCIS INC, 2014年11月, ［査読有り］
英語, 研究論文（学術雑誌）, Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality and has increasingly become a disease of elderly patients. Elderly patients are underrepresented in clinical trials that evaluate treatments for NSCLC. It has been suggested that patients > 65 years of age have less robust immune responses to infections, immunizations, and tumors compared with younger patients. With increasing focus and number of immunotherapy clinical trials for NSCLC, we investigated the relationship between patient age and the tumor immune microenvironment in NSCLC. Using tissue microarrays from 1,278 patients with surgically resected Stage I NSCLC (<= 65 years [33%], 66-79 years [55%], and >= 80 years [12%]), we determined whether quantitative and qualitative immune cell infiltration in the tumor differed between younger and older patients. Furthermore, we investigated the prognostic value of immune cell infiltration with respect to recurrence in octogenarians. We found that there were no statistically significant differences between older and younger patients in tumoral immune infiltration or effector regulatory immune response ratios (FoxP3/CD3, FoxP3/CD4, and FoxP3/CD8 ratios). In octogenarians, presence of low tumoral CD68(+) immune cells was an independent predictor of recurrence. In the uniform cohort of surgically selected and resected Stage I NSCLC patients, tumor immune cell infiltration among the older age group resembled other age groups. Our study provides information that supports inclusion of older age patients selected for surgical resection in neoadjuvant or adjuvant immunotherapy clinical trials for lung cancer.

A case of incomplete Carney's triad.
Hideki Ujiie, Daisuke Okada, Yuki Nakajima, Hiroyasu Kinoshita, Hirohiko Akiyama
Asian cardiovascular & thoracic annals, 22, 5, 617, 9, 2014年06月, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, A 62-year-old woman, who had multiple pulmonary nodules noted 6 years earlier, and surgery for a gastrointestinal stromal tumor 2 years earlier, was found to have enlargement of her pulmonary nodules. Surgery was selected to make a definite diagnosis. Thoracoscopic segmentectomy of right segments 9 and 10 was performed, and pulmonary chondroma was diagnosed. Carney designated the combination of 3 rare soft tissue tumors (gastric leiomyosarcoma, pulmonary chondroma, and extraadrenal paraganglioma) as a syndrome. This patient may have had an incomplete type of Carney's triad with 2 lesions in the stomach and lung.

SITES, SYMPTOMS, CT SCAN FINDINGS AND SURVIVAL IN PATIENTS WITH RECURRENCE AFTER CURATIVE-INTENT SURGICAL RESECTION FOR STAGE I LUNG ADENOCARCINOMA
Hideki Ujiie, Daniel Buitrago, Kyuichi Kadota, James Huang, William D. Travis, Valerie W. Rusch, Prasad S. Adusumilli, Nabil P. Rizk
JOURNAL OF THORACIC ONCOLOGY, 8, S164, S165, LIPPINCOTT WILLIAMS & WILKINS, 2013年11月, ［査読有り］, ［筆頭著者］
英語

CD8 T-CELL INFILTRATION AND TUMOR IL-7R EXPRESSION ARE INDEPENDENT PROGNOSTIC FACTORS IN EPITHELIOID MALIGNANT PLEURAL MESOTHELIOMA
Hideki Ujiie, Daniel Buitrago, Junichi Nitadori, Kyuichi Kadota, Lee M. Krug, William D. Travis, Valerie W. Rusch, Michel Sadelain, Prasad S. Adusumilli
JOURNAL OF THORACIC ONCOLOGY, 8, S223, S224, LIPPINCOTT WILLIAMS & WILKINS, 2013年11月, ［査読有り］
英語

THE TUMOR IMMUNE MICROENVIRONMENT IN OCTOGENARIANS WITH STAGE I NON-SMALL CELL LUNG CANCER: IMPLICATIONS FOR IMMUNOTHERAPY
Ming-Ching Lee, Kyuichi Kadota, Hideki Ujiie, Nabil P. Rizk, William D. Travis, Valerie W. Rusch, Michel Sadelain, Prasad S. Adusumilli
JOURNAL OF THORACIC ONCOLOGY, 8, S373, S374, LIPPINCOTT WILLIAMS & WILKINS, 2013年11月, ［査読有り］
英語

SPREAD THROUGH ALVEOLAR SPACES (STAS): A NEWLY RECOGNIZED PATTERN OF INVASION IN LUNG ADENOCARCINOMA ASSOCIATED WITH INCREASED RECURRENCE IN PATIENTS UNDERGOING LIMITED RESECTION FOR <= 2CM TUMORS
Junichi Nitadori, Kyuichi Kadota, Camelia S. Sima, Hideki Ujiie, Nabil P. Rizk, Valerie W. Rusch, William D. Travis, Prasad S. Adusumilli
JOURNAL OF THORACIC ONCOLOGY, 8, S955, S955, LIPPINCOTT WILLIAMS & WILKINS, 2013年11月, ［査読有り］
英語

A case of coelomic cysts of the mediastinum.
Hideki Ujiie, Daisuke Okada, Yuki Nakajima, Hirohiko Akiyama
Asian cardiovascular & thoracic annals, 21, 4, 479, 81, 2013年08月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Coelomic cysts are rare cysts of mesothelial origin. They are generally unilocular and can develop in various sites. We describe a case of a multicystic lesion discovered incidentally in the anterior mediastinum of a 41-year-old man. Immunohistochemistry confirmed multiple coelomic cysts of the mediastinum.

[A case report of surgical treatment for axillary lymph node metastasis from descending colon cancer].
Isao Kikuchi, Yoji Nishimura, Kazunori Nishida, Yu Nishimura, Hideki Ujiie, Hirohiko Akiyama, Hidetsugu Hanawa, Toshimasa Yatsuoka, Katsumi Amikura, Yoshiyuki Kawashima, Hirohiko Sakamoto, Masafumi Kurosumi, Yoichi Tanaka
Gan to kagaku ryoho. Cancer & chemotherapy, 39, 12, 2252, 4, 2012年11月, ［査読有り］, ［国内誌］
日本語, 研究論文（学術雑誌）, We report a rare case of a 78-year-old woman with metachronous axillary lymph node metastasis originating from descending colon cancer. Her past medical history included right mastectomy for breast cancer at age 53 and distal gastrectomy for gastric cancer at age 70. She underwent a left hemicolectomy for descending colon adenocarcinoma in April 2011. Four months after that operation, 3 enlarging nodules in the left lung and a swollen left axillary lymph node were detected by computed tomography. No tumor was detected in the left breast by ultrasonography and mammography. The lung tumors were resected thoracoscopically, and the left axillary lymph node was excised. These specimens were histologically diagnosed as moderately differentiated adenocarcinoma, which had metastasized from colon cancer, not from the previous breast or gastric cancer. She received adjuvant chemotherapy with uracil and tegafur (UFT) plus Leucovorin for 6 months and is still alive after 12 months without recurrence.

Serum hepatocyte growth factor and interleukin-6 are effective prognostic markers for non-small cell lung cancer.
Hideki Ujiie, Mikio Tomida, Hirohiko Akiyama, Yuki Nakajima, Daisuke Okada, Naoyuki Yoshino, Yuichi Takiguchi, Hideki Tanzawa
Anticancer research, 32, 8, 3251, 8, INT INST ANTICANCER RESEARCH, 2012年08月, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, AIM: We surveyed prognostic biomarkers for resectable non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: We obtained preoperative serum from 109 patients, and measured the levels of hepatocyte growth factor (HGF), interleukin-6 (IL-6), and nicotinamide N-methytransferase (NNMT) in the sera. RESULTS: The median HGF and IL-6 contents were 860 pg/ml and 2.7 pg/ml, respectively. Analysis of survival curves indicated that an HGF or IL-6 level higher than the median was associated with poor overall survival (HGF, p=0.019; IL-6, p=0.002). In addition, we analyzed stage III lung cancer alone. Higher HGF and IL-6 levels were associated with poor overall survival (HGF, p=0.016; IL-6, p=0.013). Disease-free survival was not statistically significantly affected by these cytokine contents. The tumor status (pT factor) and nodal status (pN factor) were not associated with the survival of stage III patients. CONCLUSION: The levels of HGF and IL-6 in serum could be useful prognostic indicators of the survival of patients with stage III NSCLC undergoing surgery and chemotherapy.

Serum hepatocyte growth factor and interleukin-6 as prognostic markers for stage III non-small cell lung cancer
Hideki Ujiie, Mikio Tomida, Hirohiko Akiyama, Daisuke Okada, Yuki Nakajima, Hiroshi Sakai, Yuichi Takiguchi, Hideki Tanzawa
JOURNAL OF CLINICAL ONCOLOGY, 30, 15, AMER SOC CLINICAL ONCOLOGY, 2012年05月, ［査読有り］, ［筆頭著者］
英語

PET-CTにて異常集積を認めた,後縦隔発生Castleman病
氏家秀樹, 岡田大輔, 中島由貴, 秋山博彦
日本呼吸器外科学会雑誌, 26, 7, 791, 795, (NPO)日本呼吸器外科学会, 2012年, ［筆頭著者, 責任著者］
日本語, 症例は53歳男性。検診の胸部X線写真にて異常陰影を指摘。胸部単純CTにて、下後縦隔、胸椎近傍に38×25×50mm大の腫瘤を指摘。PET-CTにて、同部位に一致して、集積亢進を認めた(SUV max 3.37)。画像上、神経原性腫瘍が疑われ、診断、治療目的で手術の方針となった。胸腔鏡下縦隔腫瘍摘出術施行。後縦隔に血管の豊富な腫瘍を認め、止血に難渋したが、切除した。迅速組織診では明らかな悪性所見を認めず、永久病理組織検査でヒアリン血管型Castleman病の診断となった。現在追加治療なく外来にて観察中である。縦隔腫瘍は主にCTやMRIで診断がなされるが、近年付加的画像診断として、FDG-PETが用いられている。PET-CTにて異常集積を認めた、Castleman病を経験したので、画像的特徴に関して、文献的考察を加えて報告する。(著者抄録)

A case of primary solitary pulmonary plasmacytoma.
Hideki Ujiie, Daisuke Okada, Yuki Nakajima, Naoyuki Yoshino, Hirohiko Akiyama
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 18, 3, 239, 42, Japanese Editorial Committee of Annals of Thoracic and Cardiovascular Surgery, 2012年, ［査読有り］, ［筆頭著者］, ［国内誌］
英語, 研究論文（学術雑誌）, Most solitary extramedullary plasmacytomas are plasma cell tumors that tend to develop in mucosa-associated lymphoid tissues including the upper respiratory tract. We present a 43-year-old patient who was diagnosed with a solitary plasmacytoma in the lung. Primary plasmacytoma of the lung is exceedingly rare, and the treatment is surgical excision. This malignancy advances to multiple myeloma in a minority of patients. Multiple myeloma is a plasma cell malignancy that typically presents in the bone marrow.

後縦隔の静脈血管腫の一例
YOSHINO Naoyuki, OKADA Daisuke, UJIIE Hideki, AKIYAMA Hirohiko, NISHIMURA Yu, KOIZUMI Kiyoshi, SHIMIZU Kazuo
Annals of Thoracic and Cardiovascular Surgery, 18, 3, 247, 50, Japanese Editorial Committee of Annals of Thoracic and Cardiovascular Surgery, 2012年, ［査読有り］, ［国内誌］
英語, Here, we describe our experience in treating a patient with mediastinal hemangioma, a rare neoplasm. An abnormal shadow was noted in the thoracic region of a 54-year-old woman at a health checkup, and she was referred to our hospital. A neurogenic tumor was suspected based on the findings of the chest X-ray and computed tomography scan. Thoracoscopic tumorectomy was performed. The tumor surface was smooth with a reddish-dark reddish color, and capillary blood vessels showed marked growth around the tumor. The tumor was composed of medium or large blood vessels with a relatively thick vascular wall containing smooth muscle. On immunostaining, anti-CD34 antibody and Factor VIII were positive and D2-40 was negative. Based on these findings, the tumor was diagnosed as mediastinal venous hemangioma.

A case of stage IIIB lung cancer treated with concurrent chemoradiotherapy followed by successful tumor resection.
Hideki Ujiie, Hirohiko Akiyama
Japanese journal of clinical oncology, 41, 11, 1312, 1312, Oxford University Press, 2011年11月, ［査読有り］, ［筆頭著者, 責任著者］, ［国際誌］
英語

肺原発淡明細胞腫の一切除例
氏家秀樹, 吉野直之, 中島由貴, 岡田大輔, 秋山博彦
日本呼吸器外科学会雑誌, 25, 7, 815, 819, (NPO)日本呼吸器外科学会, 2011年, ［筆頭著者, 責任著者］
日本語, 非常に稀な肺原発淡明細胞腫の1切除例を経験した。症例は57歳女性。胸部打撲精査で施行した胸部X線写真にて、右下肺野に結節影を指摘された。胸部CTにて右中葉に辺縁整で、比較的造影効果の高い14mm大の結節を認め、転移性肺腫瘍または良性腫瘍を疑わせる所見であった。FDG-PETでは右中葉の結節影を含めて、全身に明らかな異常集積を認めなかった。診断および治療目的で胸腔鏡下右肺中葉部分切除術を施行した。腫瘍は、19×13×10mm大、白色調、充実性腫瘍であり、病理所見では、細胞異型は乏しく、壊死や核分裂像は明らかではなく、淡明で比較的豊かな細胞質を有する明細胞が充実性に増殖していた。免疫組織化学的染色ではHMB45(+)、vimentin(+)、TTF-1(-)、SP-A(-)、AE1/3(-)、CAM5.2(-)であった。以上より、肺原発淡明細胞腫と診断された。(著者抄録)

A Case with Resection of Primary Pulmonary Clear Cell Tumor
Hideki Ujiie, Daisuke Okada, Yuki Nakajima, Naoyuki Yoshino, Hirohiko Akiyama
Annals of Thoracic and Cardiovascular Surgery, Int Acad Publishing Co Ltd, 2011年, ［査読有り］, ［筆頭著者, 責任著者］
英語, 研究論文（学術雑誌）, We experienced an extremely rare case of primary pulmonary clear cell tumor. The patient was a 57-year-old female who was suggested to have a nodular shadow in the right lower lung field. In chest CT, a well-defined 14-mm node was observed in the right median lobe. For diagnosis and treatment, thoracoscopic resection of the right pulmonary median lobe was performed. The tumor was white, solid tumor. The pathological findings showed an increase in solid, clear cells with clear and comparatively abundant cytoplasm. Immunohistochemical staining showed HMB45 (+), vimentin (+). The tumor was diagnosed as a primary pulmonary clear cell tumor.

肺虚血再灌流傷害におけるエリスロポエチンアナログ製剤の効果　　　　　　　　　　　　　　　
椎谷 洋彦, 渡辺 正明, 千葉 龍平, 佐々木 明洋, 大高 和人, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加藤 達哉, 移植, 59, 総会臨時, 375, 375, 2024年09月
(一社)日本移植学会, 日本語

先天性嚢胞性肺疾患に対するReduced port VATSの取り組み　　　　　　　　　　　　　　　
藤原 晶, 高桑 佑佳, 佐々木 明洋, 椎谷 洋彦, 大高 和人, 氏家 秀樹, 新垣 雅人, 本多 昌平, 川原 仁守, 加藤 達哉, 日本気胸・嚢胞性肺疾患学会雑誌, 24, 2, 86, 86, 2024年08月
日本気胸・嚢胞性肺疾患学会, 日本語

ラット虚血再灌流傷害モデルを用いた新規抗炎症薬による肺傷害抑制効果の検討
椎谷 洋彦, 千葉 龍平, 渡辺 正明, 大塚 将平, 佐々木 明洋, 大高 和人, 氏家 秀樹, 藤原 晶, 新垣 雅人, 加藤 達哉, 移植, 59, 1, 88, 88, 2024年07月
(一社)日本移植学会, 日本語

肺移植クラウドファンディングを経験して
加藤 達哉, 大塚 将平, 佐々木 明洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 氏家 秀樹, 新垣 雅人, 移植, 59, 1, 101, 101, 2024年07月
(一社)日本移植学会, 日本語

上海市肺科医院見学を通しての学び
平良 彰浩, 田中 文啓, 江花 弘基, 氏家 秀樹, 肺癌, 64, 3, 215, 215, 2024年06月
(NPO)日本肺癌学会, 日本語

右大腿発生粘液型脂肪肉腫に肺転移を擬した肺クリプトコッカス病を併発した1例
河村 茉莉子, 松岡 正剛, 氏家 秀樹, 有賀 伸, 中里 信一, 加藤 憲士郎, 橋本 孝之, 松野 吉宏, 加藤 達哉, 岩崎 倫政, 日本整形外科学会雑誌, 98, 6, S1566, S1566, 2024年06月
(公社)日本整形外科学会, 日本語

低侵襲手術の未来像 Reduced port Robot-assisted thoracic surgery(RATS)の未来
氏家 秀樹, 大塚 将平, 佐々木 明洋, 山崎 洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 新垣 雅人, 江花 弘基, 加藤 達哉, 気管支学, 46, Suppl., S171, S171, 2024年05月
(一社)日本呼吸器内視鏡学会, 日本語

低侵襲手術の未来像 Reduced port Robot-assisted thoracic surgery(RATS)の未来
氏家 秀樹, 大塚 将平, 佐々木 明洋, 山崎 洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 新垣 雅人, 江花 弘基, 加藤 達哉, 気管支学, 46, Suppl., S171, S171, 2024年05月
(一社)日本呼吸器内視鏡学会, 日本語

北海道大学病院呼吸器外科における医師のオンコール体制の導入　　　　　　　　　　　　　　　
藤原 晶, 大塚 将平, 佐々木 明洋, 山崎 洋, 椎谷 洋彦, 大高 和人, 氏家 秀樹, 新垣 雅人, 加藤 達哉, 日本呼吸器外科学会雑誌, 38, 3, PS4, 3, 2024年04月
(一社)日本呼吸器外科学会, 日本語

左上葉肺癌に対する肺葉切除と区域切除の傾向スコアマッチングを用いた長期成績比較　　　　　　　　　　　　　　　
竹野 巨樹, 野村 俊介, 大塚 将平, 山崎 洋, 佐々木 明洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 氏家 秀樹, 新垣 雅人, 千葉 龍平, 椎名 伸行, 加地 苗人, 加藤 達哉, 日本呼吸器外科学会雑誌, 38, 3, O6, 2, 2024年04月
(一社)日本呼吸器外科学会, 日本語

Reduced port Robot-assisted thoracic surgery(RATS)の定型化の取り組み 利点および欠点の検討　　　　　　　　　　　　　　　
氏家 秀樹, 大塚 将平, 佐々木 明洋, 山崎 洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 新垣 雅人, 江花 弘基, 加藤 達哉, 日本呼吸器外科学会雑誌, 38, 3, O26, 3, 2024年04月
(一社)日本呼吸器外科学会, 日本語

TOUCHCLASSを用いた手術教育システムの構築　　　　　　　　　　　　　　　
新垣 雅人, 大塚 将平, 佐々木 明洋, 山崎 洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 氏家 秀樹, 加藤 達哉, 日本呼吸器外科学会雑誌, 38, 3, O31, 7, 2024年04月
(一社)日本呼吸器外科学会, 日本語

7気管輪の気管環状切除を施行した下部気管腺様嚢胞癌の1例　　　　　　　　　　　　　　　
佐々木 明洋, 大塚 将平, 山崎 洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加藤 達哉, 日本呼吸器外科学会雑誌, 38, 3, O34, 7, 2024年04月
(一社)日本呼吸器外科学会, 日本語

薬物療法後の縦隔内再発に対してロボット支援下腫瘍摘除術を施行した二相型胸膜中皮腫の1例　　　　　　　　　　　　　　　
岡村 峻, 佐々木 明洋, 大塚 将平, 山崎 洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加藤 達哉, 日本呼吸器外科学会雑誌, 38, 3, MO24, 3, 2024年04月
(一社)日本呼吸器外科学会, 日本語

胸膜中皮腫術後のアスペルギルス膿胸に対し外用抗真菌薬の胸腔内塗布が有効であった1例　　　　　　　　　　　　　　　
野村 俊介, 藤原 晶, 大塚 将平, 竹野 巨樹, 山崎 洋, 佐々木 明洋, 椎谷 洋彦, 大高 和人, 氏家 秀樹, 新垣 雅人, 長 靖, 加藤 達哉, 日本呼吸器外科学会雑誌, 38, 3, MO50, 5, 2024年04月
(一社)日本呼吸器外科学会, 日本語

肺静脈先行処理は原発性肺癌術後の再発を抑制する可能性がある 多施設共同研究　　　　　　　　　　　　　　　
椎谷 洋彦, 氏家 秀樹, 新垣 雅人, 藤原 晶, 大高 和人, 野村 俊介, 千葉 龍平, 加藤 達哉, 日本外科学会定期学術集会抄録集, 124回, SF, 1, 2024年04月
(一社)日本外科学会, 日本語

当院におけるReduced port Robot-assisted thoracic surgery(RATS)の定型化の取り組み　　　　　　　　　　　　　　　
氏家 秀樹, 竹野 巨樹, 佐々木 明洋, 山崎 洋, 野村 俊介, 椎谷 洋彦, 大高 和人, 藤原 晶, 新垣 雅人, 加藤 達哉, 日本外科学会定期学術集会抄録集, 124回, PS, 6, 2024年04月
(一社)日本外科学会, 日本語

術前検査で偶発的に発見されたMinute pulmonary meningothelial-like nodulesの1例
小林 圭太, 吉川 仁人, 高柳 歩, 常田 慧徳, 中川 純一, 木村 理奈, 西岡 典子, 坂本 圭太, 加藤 扶美, 岡崎 ななせ, 松野 吉宏, 氏家 秀樹, 工藤 與亮, 北海道放射線医学雑誌, 4, 25, 29, 2024年03月
症例は70代男性。肺癌に対する術前精査目的のCTで両肺に3mm前後のすりガラス状微小結節を多数認めた。一部の結節では内部に空洞を伴っていた。右上葉肺腺癌に対して右肺上葉切除術が施行され、病理組織学的にはMinute pulmonary meningothelial-like nodule(MPMN)の多発が確認された。MPMNは組織学的に髄膜腫細胞と類似の形態を示す比較的稀な肺良性病変であり、両肺にすりガラス状の微小結節を複数認めた場合には鑑別にあげるべき疾患の一つとして考慮する必要がある。病変が空洞を伴う場合にはMPMNがより示唆される可能性はあるが、MPMNはその他の特異的な画像所見に乏しく、一般に転移性肺腫瘍を含めた悪性病変との厳密な鑑別は画像のみでは困難であり、長期間の経過観察が望ましい。(著者抄録), (NPO)メディカルイメージラボ, 日本語

【体腔鏡手術の教え方・学び方】呼吸器 Virtual reality技術を活用した呼吸器外科ロボットトレーニング法
氏家 秀樹, 外科, 86, 3, 278, 282, 2024年03月
＜文献概要＞呼吸器外科ロボット手術における視覚と操作の制限を克服するため,virtual reality(VR)技術を活用した場合の有用性を評価した.術前のCTデータを用いて3Dイメージを作成し,head mount display(HMD)を装着してVR空間での観察を行うことと実際の手術操作の感覚を組み合わせることの有効性が示された.このシステムは実際の手術前のトレーニングにも有用であると考える., (株)南江堂, 日本語

肺病立性毛細血管腫の2切除例と文献的考察　　　　　　　　　　　　　　　
大川 紘弥, 外丸 詩野, 若林 健人, 中里 信一, 岡崎 ななせ, 加藤 憲士郎, 宮石 陸, 氏家 秀樹, 加藤 達哉, 松野 吉宏, 日本病理学会会誌, 113, 1, 362, 362, 2024年02月
(一社)日本病理学会, 日本語

低血糖発作を合併した胸膜孤立性線維性腫瘍の1例　　　　　　　　　　　　　　　
村本 朋之, 中川 純一, 常田 慧徳, 高橋 文也, 木村 理奈, 西岡 典子, 坂本 圭太, 加藤 扶美, 氏家 秀樹, 加藤 達哉, 大藤 悠里, 亀田 啓, 中村 昭伸, 若林 健人, 松野 吉宏, 工藤 與亮, Japanese Journal of Radiology, 42, Suppl., 4, 4, 2024年02月
(公社)日本医学放射線学会, 日本語

肺孤立性毛細血管腫の2症例
大川 紘弥, 若林 健人, 中里 信一, 加藤 憲士郎, 宮石 陸, 松野 吉宏, 氏家 秀樹, 加藤 達哉, 肺癌, 64, 1, 58, 58, 2024年02月
(NPO)日本肺癌学会, 日本語

肺病立性毛細血管腫の2切除例と文献的考察
大川 紘弥, 外丸 詩野, 若林 健人, 中里 信一, 岡崎 ななせ, 加藤 憲士郎, 宮石 陸, 氏家 秀樹, 加藤 達哉, 松野 吉宏, 日本病理学会会誌, 113, 1, 362, 362, 2024年02月
(一社)日本病理学会, 日本語

肺類上皮血管内皮腫と肺腺癌が混在した多発肺結節影の1例　　　　　　　　　　　　　　　
藤原 晶, 山崎 雅久, 千葉 龍平, 野村 俊介, 武藤 潤, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 若林 健人, 松野 吉宏, 加藤 達哉, 日本臨床外科学会雑誌, 85, 2, 306, 306, 2024年02月
日本臨床外科学会, 日本語

低血糖発作を合併した胸膜孤立性線維性腫瘍の1例　　　　　　　　　　　　　　　
村本 朋之, 中川 純一, 常田 慧徳, 高橋 文也, 木村 理奈, 西岡 典子, 坂本 圭太, 加藤 扶美, 氏家 秀樹, 加藤 達哉, 大藤 悠里, 亀田 啓, 中村 昭伸, 若林 健人, 松野 吉宏, 工藤 與亮, Japanese Journal of Radiology, 42, Suppl., 4, 4, 2024年02月
(公社)日本医学放射線学会, 日本語

肺転移との鑑別を要した右大腿発生粘液型脂肪肉腫に伴う肺クリプトコッカス病の一例
河村 茉莉子, 松岡 政剛, 岩崎 倫政, 氏家 秀樹, 加藤 達哉, 有賀 伸, 中里 信一, 加藤 憲士郎, 松野 吉宏, 橋本 孝之, 北海道整形災害外科学会雑誌, 66, 143rd suppl, 44, 44, 2024年
北海道整形災害外科学会, 日本語

肺孤立性毛細血管腫の2症例
大川紘弥, 若林健人, 中里信一, 加藤憲士郎, 宮石陸, 松野吉宏, 氏家秀樹, 加藤達哉, 肺癌(Web), 64, 1, 2024年

肺静脈初回肺葉切除は臨床的N0原発性肺癌患者における術後予後を改善する可能性がある: 多施設傾向スコアマッチング研究【JST機械翻訳】|||
SHIIYA Haruhiko, UJIIE Hideki, OTSUKA Shohei, YAMASAKI Hiroshi, SASAKI Akihiro, CHIBA Ryohei, NOMURA Shunsuke, OHTAKA Kazuto, FUJIWARA-KURODA Aki, ARAGAKI Masato, KATO Tatsuya, 薬理と臨床, 34, 2, 2024年

ロボット支援胸部手術における水平開胸視野による修正前方アプローチ【JST機械翻訳】|||
OHTAKA Kazuto, OTSUKA Shohei, YAMASAKI Hiroshi, SASAKI Akihiro, SHIIYA Haruhiko, FUJIWARA-KURODA Akli, UJIIE Hideki, ARAGAKI Masato, KATO Tatsuya, 薬理と臨床, 34, 2, 2024年

Reduced port Robot-assisted thoracic surgery(RATS)の未来
氏家秀樹, 大塚将平, 佐々木明洋, 山崎洋, 椎谷洋彦, 大高和人, 藤原晶, 新垣雅人, 江花弘基, 加藤達哉, 気管支学, 46, 2024年

薬物療法後の縦隔内再発に対してロボット支援下腫瘍摘除術を施行した二相型胸膜中皮腫の1例
岡村峻, 佐々木明洋, 大塚将平, 山崎洋, 椎谷洋彦, 大高和人, 藤原晶, 氏家秀樹, 新垣雅人, 加藤達哉, 日本呼吸器外科学会総会(Web), 41st, 3, MO24, 3, 2024年
(一社)日本呼吸器外科学会, 日本語

TOUCHCLASSを用いた手術教育システムの構築
新垣雅人, 大塚将平, 佐々木明洋, 山崎洋, 椎谷洋彦, 大高和人, 藤原晶, 氏家秀樹, 加藤達哉, 日本呼吸器外科学会総会(Web), 41st, 3, O31, 7, 2024年
(一社)日本呼吸器外科学会, 日本語

Reduced port Robot-assisted thoracic surgery(RATS)の定型化の取り組み-利点および欠点の検討
氏家秀樹, 大塚将平, 佐々木明洋, 山崎洋, 椎谷洋彦, 大高和人, 藤原晶, 新垣雅人, 江花弘基, 加藤達哉, 日本呼吸器外科学会総会(Web), 41st, 3, O26, 3, 2024年
(一社)日本呼吸器外科学会, 日本語

北海道大学病院呼吸器外科における医師のオンコール体制の導入
藤原晶, 大塚将平, 佐々木明洋, 山崎洋, 椎谷洋彦, 大高和人, 氏家秀樹, 新垣雅人, 加藤達哉, 日本呼吸器外科学会総会(Web), 41st, 3, PS4, 3, 2024年
(一社)日本呼吸器外科学会, 日本語

左上葉肺癌に対する肺葉切除と区域切除の傾向スコアマッチングを用いた長期成績比較
竹野巨樹, 野村俊介, 大塚将平, 山崎洋, 佐々木明洋, 椎谷洋彦, 大高和人, 藤原晶, 氏家秀樹, 新垣雅人, 千葉龍平, 椎名伸行, 加地苗人, 加藤達哉, 日本呼吸器外科学会総会(Web), 41st, 3, O6, 2, 2024年
(一社)日本呼吸器外科学会, 日本語

胸膜中皮腫術後のアスペルギルス膿胸に対し外用抗真菌薬の胸腔内塗布が有効であった1例
野村俊介, 藤原晶, 大塚将平, 竹野巨樹, 山崎洋, 佐々木明洋, 椎谷洋彦, 大高和人, 氏家秀樹, 新垣雅人, 長靖, 加藤達哉, 日本呼吸器外科学会総会(Web), 41st, 3, MO50, 5, 2024年
(一社)日本呼吸器外科学会, 日本語

7気管輪の気管環状切除を施行した下部気管腺様嚢胞癌の1例
佐々木明洋, 大塚将平, 山崎洋, 椎谷洋彦, 大高和人, 藤原晶, 氏家秀樹, 新垣雅人, 加藤達哉, 日本呼吸器外科学会総会(Web), 41st, 3, O34, 7, 2024年
(一社)日本呼吸器外科学会, 日本語

当院におけるReduced port Robot-assisted thoracic surgery(RATS)の定型化の取り組み
氏家秀樹, 竹野巨樹, 佐々木明洋, 山崎洋, 野村俊介, 椎谷洋彦, 大高和人, 藤原晶, 新垣雅人, 加藤達哉, 日本外科学会定期学術集会(Web), 124th, PS, 6, 2024年
(一社)日本外科学会, 日本語

肺静脈先行処理は原発性肺癌術後の再発を抑制する可能性がある-多施設共同研究-
椎谷洋彦, 氏家秀樹, 新垣雅人, 藤原晶, 大高和人, 野村俊介, 千葉龍平, 加藤達哉, 日本外科学会定期学術集会(Web), 124th, SF, 1, 2024年
(一社)日本外科学会, 日本語

前方アプローチ(対面倒立視野)によるロボット支援下肺葉切除術
大高和人, 竹野巨樹, 佐々木明洋, 山崎洋, 野村俊介, 藤原晶, 氏家秀樹, 新垣雅人, 加藤達哉, 日本ロボット外科学会学術集会プログラム・抄録集, 16th, 2024年

肺類上皮血管内皮腫と肺腺癌が混在した多発肺結節影の1例
藤原晶, 山崎雅久, 千葉龍平, 野村俊介, 武藤潤, 氏家秀樹, 新垣雅人, 加賀基知三, 若林健人, 松野吉宏, 加藤達哉, 日本臨床外科学会雑誌, 85, 2, 306, 306, 2024年
日本臨床外科学会, 日本語

小児胸腔鏡下肺切除の肝 小児に対する胸腔鏡下肺切除術の成績と課題　　　　　　　　　　　　　　　
加賀 基知三, 河原 仁守, 藤原 晶, 新垣 雅人, 氏家 秀樹, 本多 昌平, 武冨 紹信, 加藤 達哉, 日本内視鏡外科学会雑誌, 28, 7, 2013, 2013, 2023年12月
(一社)日本内視鏡外科学会, 日本語

縦隔疾患に対する低侵襲手術を考える 側方アプローチによる単孔式ロボット支援下縦隔腫瘍摘出術　　　　　　　　　　　　　　　
江花 弘基, 渡辺 光, 鈴木 潤, 氏家 秀樹, 佐藤 開仁, 日本内視鏡外科学会雑誌, 28, 7, 2298, 2298, 2023年12月
(一社)日本内視鏡外科学会, 日本語

小型肺癌時代における治療戦略 呼吸器外科医と呼吸器内視鏡の展望
氏家 秀樹, 気管支学, 45, 6, 441, 441, 2023年11月
(一社)日本呼吸器内視鏡学会, 日本語

薄壁空洞性病変を呈した原発性肺扁平上皮内癌の1例
佐々木 明洋, 新垣 雅人, 竹野 巨樹, 山崎 洋, 野村 俊介, 大高 和人, 藤原 晶, 氏家 秀樹, 榊原 純, 大川 紘弥, 松野 吉宏, 加藤 達哉, 気管支学, 45, 6, 443, 443, 2023年11月
(一社)日本呼吸器内視鏡学会, 日本語

手術記録におけるメディカルイラストの利用　　　　　　　　　　　　　　　
加賀 基知三, 藤原 晶, 新垣 雅人, 氏家 秀樹, 加藤 達哉, 日本臨床外科学会雑誌, 84, 増刊, S111, S111, 2023年10月
日本臨床外科学会, 日本語

悪性胸膜中皮腫に対する治療の最前線 悪性胸膜中皮腫における免疫応答と免疫チェックポイント阻害剤の効果予測因子の解析
榊原 里江, Yin Yuting, 本多 隆行, 桐村 進, 小林 正嗣, 安藤 耕平, 氏家 秀樹, 加藤 達哉, 加賀 基知三, 三ツ村 隆弘, 中野 亮二, 坂下 博之, 松毛 伸一, 石橋 洋則, 明石 巧, 樋田 泰浩, 諸星 隆夫, 東 みゆき, 大久保 憲一, 宮崎 泰成, 肺癌, 63, 5, 413, 413, 2023年10月
(NPO)日本肺癌学会, 日本語

ここまできた肺癌の低侵襲手術 当院におけるReduced port RATSの取り組み
氏家 秀樹, 竹野 巨樹, 佐々木 明洋, 山崎 洋, 野村 俊介, 大高 和人, 藤原 晶, 新垣 雅人, 加藤 達哉, 肺癌, 63, 5, 415, 415, 2023年10月
(NPO)日本肺癌学会, 日本語

Reduced port RATSの取り組み Uniportal RATS確立へ向けて　　　　　　　　　　　　　　　
氏家 秀樹, 竹野 巨樹, 佐々木 明洋, 山崎 洋, 野村 俊介, 大高 和人, 藤原 晶, 新垣 雅人, 加藤 達哉, 日本胸部外科学会定期学術集会, 76回, LCV2, 2, 2023年10月
(一社)日本胸部外科学会, 日本語

胸腺癌27例の手術治療成績 2施設共同研究　　　　　　　　　　　　　　　
新垣 雅人, 千葉 龍平, 藤原 晶, 氏家 秀樹, 大高 和人, 野村 俊介, 佐々木 明洋, 山崎 洋, 竹野 巨樹, 加地 苗人, 加藤 達哉, 日本胸部外科学会定期学術集会, 76回, LP6, 5, 2023年10月
(一社)日本胸部外科学会, 日本語

ドナー肺を体外肺灌流と10℃保存した後に両側肺葉移植を施行した一例
新垣 雅人, 稲毛 輝長, 川島 光明, 谷口 大輔, 石綿 司, 氏家 秀樹, 藤原 晶, 大高 和人, 椎谷 洋彦, 加藤 達哉, 安福 和弘, Keshavjee Shaf, Cypel Mercelo, 移植, 58, 総会臨時, 295, 295, 2023年09月
(一社)日本移植学会, 日本語

Identification of micro-recurrent lesions using methylene blue for mediastinal ectopic parathyroid adenoma: a case report(タイトル和訳中)
Nomura Shunsuke, Ujiie Hideki, Fujiwara-Kuroda Aki, Kaga Kichizo, Aragaki Masato, Muto Jun, Chiba Ryohei, Yamazaki Gaku, Wakabayashi Kento, Matsuno Yoshihiro, Kato Tatsuya, General Thoracic and Cardiovascular Surgery Cases, 2, 1, 1 of 4, 4 of 4, 2023年08月, ［国際誌］
BACKGROUND: Mediastinal ectopic parathyroid adenomas are rare, and several methods are used to diagnose and localize them preoperatively. Technetium-99m methoxy isobutyl isonitrile scintigraphy has been used to diagnose parathyroid tumors. However, it is difficult to identify tumors buried in adipose tissue during surgery. CASE PRESENTATION: We report a case in which methylene blue effectively identified small recurrent lesions in a mediastinal ectopic parathyroid adenoma. After intravenous injection of methylene blue prior to surgery, the stained parathyroid adenoma was easily identifiable. Additionally, we identified other small recurrent lesions that could not be confirmed on preoperative imaging using real-time in vivo imaging guidance during surgery. Using this strategy, complete macroscopic resection can be performed during video-assisted thoracic surgery. CONCLUSION: Preoperative intravenous methylene blue injection is useful for identifying small recurrent lesions, even in cases of mediastinal ectopic parathyroid adenoma with suspected recurrence., BioMed Central, 英語

肺胞出血を合併したLymphangioleiomyomatosisの1例
大高 和人, 竹野 巨樹, 山崎 洋, 佐々木 明洋, 野村 俊介, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加藤 達哉, 武井 望, 小熊 昂, 今野 哲, 大川 紘弥, 松野 吉宏, 日本気胸・嚢胞性肺疾患学会雑誌, 23, 2, 90, 90, 2023年08月
日本気胸・嚢胞性肺疾患学会, 日本語

気管支3Dモデルを用いた手術シミュレーション　　　　　　　　　　　　　　　
藤原 晶, 山崎 雅久, 千葉 龍平, 野村 俊介, 武藤 潤, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 道田 共博, 若林 侑輝, 佐伯 和紀, 山口 仰, 加藤 達哉, 日本呼吸器外科学会雑誌, 37, 3, O39, 6, 2023年06月
(一社)日本呼吸器外科学会, 日本語

術後経時的ctDNA測定と腫瘍マーカーを併用した肺癌術後フォローアップ法は再発検出率を向上させる　　　　　　　　　　　　　　　
加藤 達哉, Ming Chin Yoon, Low Siew-Kee, 清谷 一馬, 氏家 秀樹, 藤原 晶, 新垣 雅人, 中村 祐輔, 日本呼吸器外科学会雑誌, 37, 3, O52, 3, 2023年06月
(一社)日本呼吸器外科学会, 日本語

術前、術後免疫チェックポイント阻害薬および肺剥皮術による集学的治療を行ったびまん性胸膜中皮腫の1例　　　　　　　　　　　　　　　
山崎 雅久, 藤原 晶, 千葉 龍平, 野村 俊介, 武藤 潤, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 古田 恵, 大野 桜子, 松野 吉宏, 加藤 達哉, 日本呼吸器外科学会雑誌, 37, 3, O59, 2, 2023年06月
(一社)日本呼吸器外科学会, 日本語

左上葉切除後の脳梗塞発症予防として肺静脈心嚢内処理を施行した症例の検討　　　　　　　　　　　　　　　
武藤 潤, 山崎 雅久, 千葉 龍平, 野村 俊介, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 加藤 達哉, 日本呼吸器外科学会雑誌, 37, 3, O73, 5, 2023年06月
(一社)日本呼吸器外科学会, 日本語

巨大ダンベル型脊髄腫瘍に対する、後方アプローチおよびロボット支援下手術(RATS)　　　　　　　　　　　　　　　
氏家 秀樹, 中谷 匠, 山崎 雅久, 野村 俊介, 千葉 龍平, 武藤 潤, 藤原 晶, 新垣 雅人, 加賀 基知三, 高畑 雅彦, 松野 吉宏, 加藤 達哉, 日本呼吸器外科学会雑誌, 37, 3, P42, 1, 2023年06月
(一社)日本呼吸器外科学会, 日本語

多発胸腺腫疑いに対し手術を施行し、胸腺癌と胸腺腫の同時多発が判明した1例　　　　　　　　　　　　　　　
中谷 匠, 野村 俊介, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 加藤 憲士郎, 松野 吉宏, 加藤 達哉, 日本呼吸器外科学会雑誌, 37, 3, P68, 7, 2023年06月
(一社)日本呼吸器外科学会, 日本語

ロボット支援下左上葉切除術におけるポートホッピングの有用性
林 諭史, 川田 将也, 藤原 晶, 氏家 秀樹, 日本呼吸器外科学会雑誌, 37, 3, O38, 1, 2023年06月
(一社)日本呼吸器外科学会, 日本語

気管支3Dモデルを用いた手術シミュレーション
藤原 晶, 山崎 雅久, 千葉 龍平, 野村 俊介, 武藤 潤, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 道田 共博, 若林 侑輝, 佐伯 和紀, 山口 仰, 加藤 達哉, 日本呼吸器外科学会雑誌, 37, 3, O39, 6, 2023年06月
(一社)日本呼吸器外科学会, 日本語

術後経時的ctDNA測定と腫瘍マーカーを併用した肺癌術後フォローアップ法は再発検出率を向上させる
加藤 達哉, Ming Chin Yoon, Low Siew-Kee, 清谷 一馬, 氏家 秀樹, 藤原 晶, 新垣 雅人, 中村 祐輔, 日本呼吸器外科学会雑誌, 37, 3, O52, 3, 2023年06月
(一社)日本呼吸器外科学会, 日本語

術前、術後免疫チェックポイント阻害薬および肺剥皮術による集学的治療を行ったびまん性胸膜中皮腫の1例
山崎 雅久, 藤原 晶, 千葉 龍平, 野村 俊介, 武藤 潤, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 古田 恵, 大野 桜子, 松野 吉宏, 加藤 達哉, 日本呼吸器外科学会雑誌, 37, 3, O59, 2, 2023年06月
(一社)日本呼吸器外科学会, 日本語

左上葉切除後の脳梗塞発症予防として肺静脈心嚢内処理を施行した症例の検討
武藤 潤, 山崎 雅久, 千葉 龍平, 野村 俊介, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 加藤 達哉, 日本呼吸器外科学会雑誌, 37, 3, O73, 5, 2023年06月
(一社)日本呼吸器外科学会, 日本語

巨大ダンベル型脊髄腫瘍に対する、後方アプローチおよびロボット支援下手術(RATS)
氏家 秀樹, 中谷 匠, 山崎 雅久, 野村 俊介, 千葉 龍平, 武藤 潤, 藤原 晶, 新垣 雅人, 加賀 基知三, 高畑 雅彦, 松野 吉宏, 加藤 達哉, 日本呼吸器外科学会雑誌, 37, 3, P42, 1, 2023年06月
(一社)日本呼吸器外科学会, 日本語

多発胸腺腫疑いに対し手術を施行し、胸腺癌と胸腺腫の同時多発が判明した1例
中谷 匠, 野村 俊介, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 加藤 憲士郎, 松野 吉宏, 加藤 達哉, 日本呼吸器外科学会雑誌, 37, 3, P68, 7, 2023年06月
(一社)日本呼吸器外科学会, 日本語

医学生、研修医を対象とした医学教育とメディカルイラストの利用　　　　　　　　　　　　　　　
加賀 基知三, 藤原 晶, 山崎 雅久, 千葉 龍平, 野村 俊介, 武藤 潤, 氏家 秀樹, 新垣 雅人, 加藤 達哉, 日本メディカルイラストレーション学会学術集会・総会, 7回, O, 3, 2023年03月
日本メディカルイラストレーション学会, 日本語

胸膜孤立性線維性腫瘍に合併したDoege-potter症候群の一例
村本 朋之, 中川 純一, 常田 慧徳, 高橋 文也, 木村 理奈, 西岡 典子, 坂本 圭太, 加藤 扶美, 氏家 秀樹, 加藤 達哉, 大藤 悠理, 亀田 啓, 中村 昭伸, 若林 健人, 松野 吉宏, 工藤 與亮, 北海道放射線医学雑誌, 3, 28, 32, 2023年03月
症例は60歳代女性。X-1年の検診で右胸部に異常影を指摘された。X年に胸部異常影増大と空腹時血糖38mg/dLの著明低値を認めたため前医を受診し、CTで右胸腔下部を占拠する巨大腫瘤を認めた。針生検で孤立性線維性腫瘍(solitary fibrous tumor:SFT)が疑われたため、手術目的に当院呼吸器外科に紹介受診となった。入院後低血糖時の採血でinsulinとC-peptideの低下を認めた。腫瘍はMRIではT2強調像で低信号を主体として高信号が混在し、内部にflow voidを認めた。造影後T1強調像では強く増強され、内部に血管が発達していた。腫瘍摘出術が施行され、SFTの確定診断となった。術前に頻発していた低血糖は術直後から消失し、SFTに伴う非膵島細胞腫瘍性低血糖症と考えられた。本病態はDoege-Potter症候群として知られ、SFTの5%以下の症例で生じるとされる。低血糖を合併した軟部腫瘍ではSFTが鑑別のひとつに挙げられる。(著者抄録), (NPO)メディカルイメージラボ, 日本語

膠原病科入院患者における血清アルブミン値、反応性蛋白と薬剤の評価　　　　　　　　　　　　　　　
長岡 すみか, 鷲澤 尚宏, 氏家 真二, 平澤 数馬, 田中 美奈子, 鈴木 敦, 関谷 秀樹, 南木 敏宏, 学会誌JSPEN, 5, Suppl.2, 110, 110, 2023年
(一社)日本栄養治療学会, 日本語

当院におけるReduced port RATSの取り組み
氏家秀樹, 竹野巨樹, 佐々木明洋, 山崎洋, 野村俊介, 大高和人, 藤原晶, 新垣雅人, 加藤達哉, 日本肺癌学会学術集会号, 64th (CD-ROM), 5, 415, 415, 2023年
(NPO)日本肺癌学会, 日本語

悪性胸膜中皮腫における免疫応答と免疫チェックポイント阻害剤の効果予測因子の解析
榊原里江, YIN Yuting, 本多隆行, 桐村進, 小林正嗣, 安藤耕平, 氏家秀樹, 加藤達哉, 加賀基知三, 三ツ村隆弘, 中野亮二, 坂下博之, 松毛伸一, 石橋洋則, 明石巧, 樋田泰浩, 諸星隆夫, 東みゆき, 大久保憲一, 宮崎泰成, 日本肺癌学会学術集会号, 64th (CD-ROM), 5, 413, 413, 2023年
(NPO)日本肺癌学会, 日本語

側方アプローチによる単孔式ロボット支援下縦隔腫瘍摘出術
江花弘基, 渡辺光, 鈴木潤, 氏家秀樹, 佐藤開仁, 日本内視鏡外科学会総会(Web), 36th, 7, 2298, 2298, 2023年
(一社)日本内視鏡外科学会, 日本語

小児に対する胸腔鏡下肺切除術の成績と課題
加賀基知三, 河原仁守, 藤原晶, 新垣雅人, 氏家秀樹, 本多昌平, 武冨紹信, 加藤達哉, 日本内視鏡外科学会総会(Web), 36th, 7, 2013, 2013, 2023年
(一社)日本内視鏡外科学会, 日本語

胸腺癌27例の手術治療成績~2施設共同研究~
新垣雅人, 千葉龍平, 藤原晶, 氏家秀樹, 大高和人, 野村俊介, 佐々木明洋, 山崎洋, 竹野巨樹, 加地苗人, 加藤達哉, 日本胸部外科学会定期学術集会(Web), 76th, LP6, 5, 2023年
(一社)日本胸部外科学会, 日本語

Reduced port RATSの取り組み-Uniportal RATS確立へ向けて
氏家秀樹, 竹野巨樹, 佐々木明洋, 山崎洋, 野村俊介, 大高和人, 藤原晶, 新垣雅人, 加藤達哉, 日本胸部外科学会定期学術集会(Web), 76th, LCV2, 2, 2023年
(一社)日本胸部外科学会, 日本語

ロボット支援下肺切除術におけるポート部損傷の検討
林諭史, 川田将也, 藤原晶, 氏家秀樹, 日本ロボット外科学会学術集会プログラム・抄録集, 15th, 2023年

ドナー肺を体外肺灌流と10°C保存した後に両側肺葉移植を施行した一例
新垣雅人, 新垣雅人, 稲毛輝長, 川島光明, 谷口大輔, 石綿司, 氏家秀樹, 藤原晶, 大高和人, 椎谷洋彦, 加藤達哉, 安福和弘, KESHAVJEE Shaf, CYPEL Mercelo, 日本移植学会総会プログラム抄録集, 59th (Web), 総会臨時, 295, 295, 2023年
(一社)日本移植学会, 日本語

腹臥位・人工気胸下での胸腔内剥離が有用であった巨大縦隔内甲状腺腫の1例
武藤 潤, 加納 里志, 山崎 雅久, 千葉 龍平, 野村 俊介, 藤原 晶, 氏家 秀樹, 樋田 泰浩, 加賀 基知三, 本間 明宏, 加藤 達哉, 日本臨床外科学会雑誌, 83, 12, 2119, 2119, 2022年12月
日本臨床外科学会, 日本語

胸部単純エックス線写真読影の教材としてのデジタルイラスト
加賀 基知三, 藤原 晶, 長島 諒太, 野村 俊介, 千葉 龍平, 田畑 佑希子, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 日本メディカルイラストレーション学会雑誌, 4, 1, 12, 12, 2022年12月
日本メディカルイラストレーション学会, 日本語

胸・腹腔鏡併用下に横隔膜縫縮術を施行した食道癌術後横隔膜弛緩症の1例
武藤 潤, 山崎 雅久, 千葉 龍平, 野村 俊介, 高島 雄太, 藤原 晶, 氏家 秀樹, 村上 壮一, 倉島 庸, 海老原 裕磨, 七戸 俊明, 樋田 泰浩, 加賀 基知三, 平野 聡, 加藤 達哉, 気管支学, 44, 6, 457, 457, 2022年11月
(NPO)日本呼吸器内視鏡学会, 日本語

当院職員における新型コロナウイルスワクチン接種後の抗体価の検討
大塚 慎也, 平岡 圭, 鈴置 真人, 氏家 秀樹, 加藤 達哉, 横田 勲, 米澤 一也, 小熊 恵二, 岩代 望, 加藤 元嗣, 大原 正範, 北海道医学雑誌, 97, 2, 61, 65, 2022年11月
コミナティの2回目接種を受けた当院職員401名の抗体価測定を2回目接種後約5ヵ月時に行い、背景因子との関連について検討した。全員が抗体陽性(0.8U/mL以上)で、抗体価の中央値は761.6U/mL(13.7->2500.0)であった。背景因子との関連では、女性と若年者で有意な高値を示し、高血圧を有する者と降圧薬を使用している者で有意な低値を示した。感染者との接触歴の有無や喫煙習慣の有無と抗体価との間に有意な関連はみられなかった。ワクチン接種を受けていない職員24名の抗体価を測定したところ全員が抗体陰性(0.4U/mL未満)であった。, 北海道医学会, 日本語

胸・腹腔鏡併用下に横隔膜縫縮術を施行した食道癌術後横隔膜弛緩症の1例
武藤 潤, 山崎 雅久, 千葉 龍平, 野村 俊介, 高島 雄太, 藤原 晶, 氏家 秀樹, 村上 壮一, 倉島 庸, 海老原 裕磨, 七戸 俊明, 樋田 泰浩, 加賀 基知三, 平野 聡, 加藤 達哉, 気管支学, 44, 6, 457, 457, 2022年11月
(NPO)日本呼吸器内視鏡学会, 日本語

デジタルイラストで伝わる手術記録(オペレコ)を描こう
加賀 基知三, 藤原 晶, 山崎 雅久, 千葉 龍平, 野村 俊介, 武藤 潤, 氏家 秀樹, 樋田 泰浩, 加藤 達哉, 日本気胸・嚢胞性肺疾患学会雑誌, 22, 2, 94, 94, 2022年08月
日本気胸・嚢胞性肺疾患学会, 日本語

びまん性肺疾患を有する気胸に対しての治療戦略 骨髄移植後の移植片対宿主病(GVHD)肺病変を背景とした気胸手術症例の検討
武藤 潤, 山崎 雅久, 千葉 龍平, 野村 俊介, 藤原 晶, 氏家 秀樹, 樋田 泰浩, 加賀 基知三, 加藤 達哉, 日本気胸・嚢胞性肺疾患学会雑誌, 22, 2, 107, 107, 2022年08月
日本気胸・嚢胞性肺疾患学会, 日本語

気管支充填術および持続陰圧吸引療法が有効であった有瘻性膿胸の一例
山崎 雅久, 氏家 秀樹, 野村 俊介, 千葉 龍平, 武藤 潤, 藤原 晶, 樋田 泰浩, 加賀 基知三, 三浦 瞬, 高島 雄太, 品川 尚文, 加藤 達哉, 小切開・鏡視外科学会雑誌, 13, 1, 58, 58, 2022年06月
(NPO)小切開・鏡視外科学会, 日本語

気管支充填術および持続陰圧吸引療法が有効であった有瘻性膿胸の一例
山崎 雅久, 氏家 秀樹, 野村 俊介, 千葉 龍平, 武藤 潤, 藤原 晶, 樋田 泰浩, 加賀 基知三, 三浦 瞬, 高島 雄太, 品川 尚文, 加藤 達哉, 小切開・鏡視外科学会雑誌, 13, 1, 58, 58, 2022年06月
(NPO)小切開・鏡視外科学会, 日本語

新規胸腔鏡用蛍光スペクトル測定システムは深部肺腫瘍の同定を可能にする
千葉 龍平, 加藤 達哉, 海老原 裕磨, 氏家 秀樹, 田畑 佑希子, 藤原 晶, 樋田 泰浩, 加賀 基知三, 日本外科学会定期学術集会抄録集, 122回, SF, 5, 2022年04月
(一社)日本外科学会, 日本語

3D-バーチャル・リアリティー(VR)システムを用いた、呼吸器外科ロボット手術トレーニング法の開発
氏家 秀樹, 幾島 拓也, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲, 日本外科学会定期学術集会抄録集, 122回, SF, 3, 2022年04月
(一社)日本外科学会, 日本語

Cadaverを用いた高難度呼吸器外科手術手技トレーニングの取り組み
藤原 晶, 加藤 達哉, 幾島 拓也, 千葉 龍平, 田畑 佑希子, 氏家 秀樹, 樋田 泰浩, 加賀 基知三, 日本臨床外科学会雑誌, 83, 3, 598, 598, 2022年03月
日本臨床外科学会, 日本語

切除を先行した巨大(>10cm)肺腫瘤の2症例　　　　　　　　　　　　　　　
千葉 龍平, 加賀 基知三, 幾島 拓也, 田畑 佑希子, 藤原 晶, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 若狭 哲, 岡崎 ななせ, 若林 健人, 松野 吉宏, 肺癌, 62, 1, 72, 73, 2022年02月
(NPO)日本肺癌学会, 日本語

手術により成功裏に治療した胸腺腫関連スティッフパーソン症候群
Sasaki Akihiro, Sasaki Akihiro, Kato Tatsuya, Ujiie Hideki, Wakasa Satoru, Otake Setsuyuki, Kikuchi Keisuke, Ohno Koichi, Annals of Thoracic and Cardiovascular Surgery (Web), 28, 6, 2022年

当科における単孔式複雑区域切除術の経験
藤原晶, 長島諒太, 千葉龍平, 田畑佑希子, 氏家秀樹, 加藤達哉, 樋田泰浩, 加賀基知三, 日本呼吸器外科学会総会(Web), 39th, Suppl., O86, 5, 2022年
(一社)日本呼吸器外科学会, 日本語

Hybrid手術室を利用した触知不能病変の同定と切除マージンの確認法の工夫
藤原晶, 樋田泰浩, 山崎雅久, 千葉龍平, 野村俊介, 武藤潤, 氏家秀樹, 加賀基知三, 加藤達哉, 日本胸部外科学会定期学術集会(Web), 75th, LOP4, 3, 2022年
(一社)日本胸部外科学会, 日本語

化学放射線療法後の左主気管支腺様嚢胞癌の一手術例
幾島拓也, 氏家秀樹, 千葉龍平, 野村俊介, 田畑佑希子, 藤原晶, 樋田泰浩, 加賀基知三, 品川尚文, 高島雄太, 若狭哲, 松野吉宏, 加藤達哉, 日本胸部外科学会定期学術集会(Web), 75th, LCPA2, 1, 2022年
(一社)日本胸部外科学会, 日本語

バーチャル・リアリティー(VR)システムを用いた,ロボット外科リアルタイムナビゲーション手術法の開発
氏家秀樹, 野村俊介, 千葉龍平, 山崎雅久, 武藤潤, 藤原晶, 樋田泰浩, 加賀基知三, EITEL Chad, CLAPP Tod, 加藤達哉, 日本胸部外科学会定期学術集会(Web), 75th, OP3, 1, 2022年
(一社)日本胸部外科学会, 日本語

当院職員における新型コロナウイルスワクチン接種後の抗体価の検討
大塚慎也, 大塚慎也, 平岡圭, 平岡圭, 鈴置真人, 氏家秀樹, 加藤達哉, 横田勲, 米澤一也, 小熊恵二, 岩代望, 加藤元嗣, 大原正範, 北海道医学雑誌, 97, 2, 61, 65, 2022年
コミナティの2回目接種を受けた当院職員401名の抗体価測定を2回目接種後約5ヵ月時に行い、背景因子との関連について検討した。全員が抗体陽性(0.8U/mL以上)で、抗体価の中央値は761.6U/mL(13.7->2500.0)であった。背景因子との関連では、女性と若年者で有意な高値を示し、高血圧を有する者と降圧薬を使用している者で有意な低値を示した。感染者との接触歴の有無や喫煙習慣の有無と抗体価との間に有意な関連はみられなかった。ワクチン接種を受けていない職員24名の抗体価を測定したところ全員が抗体陰性(0.4U/mL未満)であった。, 北海道医学会, 日本語

da Vinciステープラー挿入困難であったロボット支援下肺切除術導入初期の1手術例
林諭史, 川田将也, 藤原晶, 氏家秀樹, 日本呼吸器外科学会総会(Web), 39th, Suppl., O97, 3, 2022年
(一社)日本呼吸器外科学会, 日本語

右主気管支狭窄に対し心膜吊り上げ法による縦隔授動とステント留置により救命し得た一例
長島諒太, 藤原晶, 千葉龍平, 田畑佑希子, 氏家秀樹, 加藤達哉, 樋田泰浩, 加賀基知三, 若狭哲, 品川尚文, 日本呼吸器外科学会総会(Web), 39th, Suppl., CA, 3, 2022年
(一社)日本呼吸器外科学会, 日本語

ロボット支援下後縦隔腫瘍切除術における,腹臥位アプローチの有用性の検討
氏家秀樹, 海老原裕麿, 長島諒太, 千葉龍平, 野村俊介, 田畑祐希子, 藤原晶, 加藤達哉, 樋田泰浩, 加賀基知三, 若狭哲, 日本ロボット外科学会学術集会プログラム・抄録集, 14th, 2022年

ロボット支援下肺切除術における画像解析システムを用いたステープラーポート位置の選択
林諭史, 川田将也, 藤原晶, 氏家秀樹, 日本ロボット外科学会学術集会プログラム・抄録集, 14th, 2022年

当科における胸腔鏡下全胸膜被覆術(VATS-TPC)
藤原晶, 樋田泰浩, 長島諒太, 千葉龍平, 田畑佑希子, 氏家秀樹, 加藤達哉, 加賀基知三, 日本肺および心肺移植研究会プログラム・抄録集, 38th, 4, 347, 347, 2022年
(一社)日本移植学会, 日本語

腫瘍組織解析とctDNAを併用した肺癌術後のモニタリング法はMinimal residual disease検出率を向上させる
加藤達哉, MING Chin Yoon, LOW Siew-Kee, 清谷一馬, 林理絵, 藤原晶, 氏家秀樹, 加賀基知三, 中村祐輔, 日本呼吸器外科学会総会(Web), 39th, Suppl., WS2, 5, 2022年
(一社)日本呼吸器外科学会, 日本語

肺梗塞切除後の肺塞栓症の発症予測因子 症例シリーズ(Prediction of Pulmonary Embolism Following Resection of Pulmonary Infarction: A Case Series)
Yamasaki Hiroshi, Ujiie Hideki, Kato Tatsuya, Hida Yasuhiro, Kaga Kichizo, Wakasa Satoru, Matsuno Yoshihiro, Annals of Thoracic and Cardiovascular Surgery, 27, 6, 371, 379, 2021年12月
肺梗塞患者の臨床データ、X線学的所見、臨床検査値を評価し、術後経過との関連の有無を検討した。術前に確定診断に至らなかった末梢性肺結節患者603例のうち、術後に肺梗塞と診断が得られた4例(男性3例、女性1例、年齢48～74歳)を対象とした。全例が喫煙歴を有しており、結節はいずれも肺末梢部の胸膜下に存在し、4例中3例は円形、残る1例は小柱構造を呈していた。単純CTと造影CTでは増強効果は認められず、18F-FDG-PET/CTにおいて3例に造影剤の軽度集積が検出された。臨床検査値に関して、1例のみにD-ダイマー高値を認めたが、全例に炎症性反応はみられず、血液ガス分析でも異常所見はなかった。全例に胸腔鏡下肺楔状切除術を施行し、術中所見では3例に胸膜圧入、1例に胸膜プラークを認めた。術後の病理所見にて全例に胸膜下肺実質における結節性病変が検出され、組織学的に組織球と単核細胞の浸潤を伴った凝固壊死領域で構成されており、免疫染色の結果と合わせて肺梗塞と診断した。その後の経過は良好であったが、1例に術後慢性期に肺塞栓症を認め、アピキサバン投与によって血栓の消失が得られた。この1例は術前D-ダイマーが高値を示していた症例であり、このような患者に対しては予防的抗凝固薬投与も考慮する必要があると思われた。, 「Annals of Thoracic and Cardiovascular Surgery」編集委員会, 英語

難治性肺瘻をどう取り扱うか 肺切除後難治性肺瘻の治療戦略　　　　　　　　　　　　　　　
加賀 基知三, 樋田 泰浩, 加藤 達哉, 藤原 晶, 氏家 秀樹, 田畑 佑希子, 野村 俊介, 千葉 龍平, 幾島 拓也, 若狭 哲, 日本内視鏡外科学会雑誌, 26, 7, WS32, 3, 2021年12月
(一社)日本内視鏡外科学会, 日本語

α-グルコシダーゼ阻害薬内服中に発症した肺移植後の腸管嚢胞様気腫症の一例
大塚 慎也, 氏家 秀樹, 加藤 達哉, 椎谷 洋彦, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 井上 玲, 飯村 泰昭, 北海道外科雑誌 = The Hokkaido journal of surgery / 北海道外科雑誌編集委員会 編, 66, 2, 131, 133, 2021年12月
北海道外科学会, 日本語

有瘻性膿胸に対し気管支充填術と持続陰圧吸引療法を併用した2症例
田畑 佑希子, 加藤 達哉, 大塚 慎也, 幾島 拓也, 千葉 龍平, 藤原 晶, 氏家 秀樹, 樋田 泰浩, 品川 尚文, 有里 仁希, 高島 雄太, 加賀 基知三, 若狭 哲, 気管支学, 43, 6, 689, 689, 2021年11月
(NPO)日本呼吸器内視鏡学会, 日本語

有瘻性膿胸に対し気管支充填術と持続陰圧吸引療法を併用した2症例
田畑 佑希子, 加藤 達哉, 大塚 慎也, 幾島 拓也, 千葉 龍平, 藤原 晶, 氏家 秀樹, 樋田 泰浩, 品川 尚文, 有里 仁希, 高島 雄太, 加賀 基知三, 若狭 哲, 気管支学, 43, 6, 689, 689, 2021年11月
(NPO)日本呼吸器内視鏡学会, 日本語

未来のための今 胸部外科医育成のための新たなる挑戦 3D-バーチャル・リアリティー(VR)システムを用いた、呼吸器外科手術トレーニング法の開発　　　　　　　　　　　　　　　
氏家 秀樹, 幾島 拓也, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲, 日本胸部外科学会定期学術集会, 74回, SP5, 3, 2021年10月
(一社)日本胸部外科学会, 日本語

奇静脈瘤の伸展評価における4D-Flow MRIの有用性
幾島 拓也, 氏家 秀樹, 加藤 達哉, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 日本胸部外科学会定期学術集会, 74回, LOD19, 5, 2021年10月
(一社)日本胸部外科学会, 日本語

未来のための今 胸部外科医育成のための新たなる挑戦 3D-バーチャル・リアリティー(VR)システムを用いた、呼吸器外科手術トレーニング法の開発
氏家 秀樹, 幾島 拓也, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲, 日本胸部外科学会定期学術集会, 74回, SP5, 3, 2021年10月
(一社)日本胸部外科学会, 日本語

奇静脈瘤の伸展評価における4D-Flow MRIの有用性
幾島 拓也, 氏家 秀樹, 加藤 達哉, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 日本胸部外科学会定期学術集会, 74回, LOD19, 5, 2021年10月
(一社)日本胸部外科学会, 日本語

バーチャル・リアリティー(VR)システムを用いた,ロボット外科手術シミュレーション法の開発
氏家 秀樹, 幾島 拓也, 千葉 龍平, 野村 俊介, 田畑 佑希子, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲, 肺癌, 61, 6, 613, 613, 2021年10月
(NPO)日本肺癌学会, 日本語

胎児治療を施行したCongenital pulmonary airway malformation(CPAM)の患児に対し日齢9で完全胸腔鏡下右上葉切除術を施行した一例
幾島 拓也, 氏家 秀樹, 加藤 達哉, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 本多 昌平, 日本気胸・嚢胞性肺疾患学会雑誌, 21, 2, 113, 113, 2021年09月
日本気胸・嚢胞性肺疾患学会, 日本語

肝移植後にPleuroparenchymal fibroelastosis(PPFE)合併肺癌を発症した一例
大塚 慎也, 加藤 達哉, 氏家 秀樹, 椎谷 洋彦, 加賀 基知三, 若狭 哲, 中村 順一, 中久保 祥, 木村 孔一, 渡辺 正明, 嶋村 剛, 岡崎 ななせ, 松野 吉宏, 田中 敏, 移植, 56, 総会臨時, P2, 7, 2021年09月
(一社)日本移植学会, 日本語

肺移植後に発症したα-グルコシダーゼ阻害薬内服中の腸管嚢胞様気腫症の一例
大塚 慎也, 氏家 秀樹, 加藤 達哉, 千葉 龍平, 椎谷 洋彦, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 井上 玲, 飯村 泰昭, 移植, 56, 1, 103, 103, 2021年07月
(一社)日本移植学会, 日本語

バーチャル・リアリティー(VR)システムを用いた、呼吸器外科手術シミュレーション法の開発
氏家 秀樹, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲, 気管支学, 43, Suppl., S241, S241, 2021年06月
(NPO)日本呼吸器内視鏡学会, 日本語

COVID-19に対する、北海道大学の取り組み　　　　　　　　　　　　　　　
氏家 秀樹, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲, 石黒 信久, 豊嶋 崇徳, 日本呼吸器外科学会雑誌, 35, 3, SP2, 3, 2021年05月
(NPO)日本呼吸器外科学会, 日本語

小児に対するReduced port VATS
加賀 基知三, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 氏家 秀樹, 藤原 晶, 加藤 達哉, 樋田 泰浩, 若狭 哲, 日本呼吸器外科学会雑誌, 35, 3, SP4, 6, 2021年05月
(NPO)日本呼吸器外科学会, 日本語

呼吸器外科におけるトランスレーショナルリサーチの最前線 ctDNAを用いた肺癌術後のMinimal residual diseaseモニタリングの有用性　　　　　　　　　　　　　　　
加藤 達哉, Low Siew-Kee, 清谷 一馬, 林 理絵, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 祐輔, 日本呼吸器外科学会雑誌, 35, 3, PD1, 5, 2021年05月
(NPO)日本呼吸器外科学会, 日本語

気管支充填術と分離陰圧閉鎖療法を併用した治療戦略　　　　　　　　　　　　　　　
大塚 慎也, 加藤 達哉, 千葉 龍平, 椎谷 洋彦, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 三浦 隆洋, 石川 耕資, 日本呼吸器外科学会雑誌, 35, 3, O14, 3, 2021年05月
(NPO)日本呼吸器外科学会, 日本語

大動脈弓部トンネリング法による効果的なドレーン留置法　　　　　　　　　　　　　　　
藤原 晶, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 日本呼吸器外科学会雑誌, 35, 3, MO16, 5, 2021年05月
(NPO)日本呼吸器外科学会, 日本語

当院でのUniportal VATS導入経験
藤原 晶, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 日本呼吸器外科学会雑誌, 35, 3, MO54, 4, 2021年05月
(NPO)日本呼吸器外科学会, 日本語

COVID-19に対する、北海道大学の取り組み
氏家 秀樹, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲, 石黒 信久, 豊嶋 崇徳, 日本呼吸器外科学会雑誌, 35, 3, SP2, 3, 2021年05月
(NPO)日本呼吸器外科学会, 日本語

小児に対するReduced port VATS
加賀 基知三, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 氏家 秀樹, 藤原 晶, 加藤 達哉, 樋田 泰浩, 若狭 哲, 日本呼吸器外科学会雑誌, 35, 3, SP4, 6, 2021年05月
(NPO)日本呼吸器外科学会, 日本語

呼吸器外科におけるトランスレーショナルリサーチの最前線 ctDNAを用いた肺癌術後のMinimal residual diseaseモニタリングの有用性
加藤 達哉, Low Siew-Kee, 清谷 一馬, 林 理絵, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 祐輔, 日本呼吸器外科学会雑誌, 35, 3, PD1, 5, 2021年05月
(NPO)日本呼吸器外科学会, 日本語

通常採血管を用いたctDNA測定による肺癌術後モニタリングは術後早期再発検出に有用である　　　　　　　　　　　　　　　
加藤 達哉, Low Siew-Kee, 清谷 一馬, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 祐輔, 日本外科学会定期学術集会抄録集, 121回, SF, 2, 2021年04月
(一社)日本外科学会, 日本語

通常採血管を用いたctDNA測定による肺癌術後モニタリングは術後早期再発検出に有用である
加藤 達哉, Low Siew-Kee, 清谷 一馬, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 祐輔, 日本外科学会定期学術集会抄録集, 121回, SF, 2, 2021年04月
(一社)日本外科学会, 日本語

小児におけるニードルスコープを用いたReduced Port video assisted thoracoscopic surgery(RPVATS)(Reduced Port video assisted thoracoscopic surgery(RPVATS) using needle scope in children)　　　　　　　　　　　　　　　
Kaga Kichizo, Hida Yasuhiro, Kato Tatsuya, Kuroda Fujiwara Akira, Shiina Nobuyuki, Ujiie Hideki, Sasaki Akihiro, Yamasaki Hiroshi, 日本内視鏡外科学会雑誌, 25, 7, OS82, 7, 2021年03月
(一社)日本内視鏡外科学会, 英語

IgG4関連肺病変を背景に生じた非角化型扁平上皮癌の一例
大塚 拓也, 伊藤 祥太郎, 松本 宗人, 氏家 秀樹, 常田 慧徳, 平田 健司, 朝比奈 肇, 加賀 基知三, 松野 吉宏, 日本病理学会会誌, 110, 1, 288, 288, 2021年03月
(一社)日本病理学会, 日本語

肺移植患者におけるEBUS(超音波気管支鏡)の役割
氏家 秀樹, 加藤 達哉, 稲毛 輝長, 石綿 司, 新垣 雅人, 樋田 泰浩, 加賀 基知三, Keshavjee Shaf, Yasufuku Kazuhiro, 移植, 55, 4, 484, 484, 2021年03月
(一社)日本移植学会, 日本語

肺メディカルコンサルタント業務の肺移植外科医以外への委嘱の展望
樋田 泰浩, 加賀 基知三, 加藤 達哉, 藤原 晶, 椎名 伸行, 氏家 秀樹, 佐々木 明洋, 山崎 洋, 大岡 智学, 移植, 55, 4, 504, 504, 2021年03月
(一社)日本移植学会, 日本語

血気胸を発症したPleuroparenchymal fibroelastosis(PPFE)合併肺癌の1切除例
大塚 慎也, 加藤 達哉, 佐々木 明洋, 山崎 洋, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 順一, 篠崎 鮎香, 中久保 祥, 木村 孔一, 渡辺 正明, 岡崎 ななせ, 松野 吉宏, 肺癌, 61, 1, 67, 67, 2021年02月
(NPO)日本肺癌学会, 日本語

神経線維腫症I型に肺腺癌、内頸動静脈瘻を合併した1例
横山 誓也, 氏家 秀樹, 加藤 達哉, 大塚 慎也, 佐々木 明洋, 山崎 洋, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 松野 吉宏, 今井 陽子, 肺癌, 61, 1, 67, 68, 2021年02月
(NPO)日本肺癌学会, 日本語

子供におけるニードルスコープを用いた減孔式ビデオ補助下胸腔鏡下手術(RP-VATS)
KAGA Kichizo, HIDA Yasuhiro, KATO Tatsuya, KURODA(FUJIWARA) Akira, SHIINA Nobuyuki, UJIIE Hideki, SASAKI Akihiro, YAMASAKI Hiroshi, 日本内視鏡外科学会総会(Web), 33rd, 2021年

神経線維腫症I型に肺腺癌,内頚動静脈瘻を合併した1例
横山誓也, 氏家秀樹, 加藤達哉, 大塚慎也, 佐々木明洋, 山崎洋, 藤原晶, 樋田泰浩, 加賀基知三, 若狭哲, 松野吉宏, 今井陽子, 肺癌(Web), 61, 1, 2021年

血気胸を発症したPleuroparenchymal fibroelastosis(PPFE)合併肺癌の1切除例
大塚慎也, 加藤達哉, 佐々木明洋, 山崎洋, 氏家秀樹, 藤原晶, 樋田泰浩, 加賀基知三, 若狭哲, 中村順一, 篠崎鮎香, 中久保祥, 木村孔一, 渡辺正明, 岡崎ななせ, 松野吉宏, 肺癌(Web), 61, 1, 2021年

肺切除後難治性肺ろうの治療戦略
加賀基知三, 樋田泰浩, 加藤達哉, 藤原晶, 氏家秀樹, 田畑佑希子, 野村俊介, 千葉龍平, 幾島拓也, 若狭哲, 日本内視鏡外科学会総会(Web), 34th, 2021年

膵癌肋骨孤立性転移に対し胸壁切除再建を施行した1例
林 諭史, 川田 将也, 氏家 秀樹, 日本呼吸器外科学会雑誌, 35, 1, 23, 26, 2021年01月, ［査読有り］
45歳男性。膵癌に対し術前化学療法後に根治手術を行い、術後化学療法を施行しつつ経過観察されていた。術後6ヵ月の胸部CTで右第4肋骨に骨硬化性腫瘤を認めたが、その他部位に病変はみられなかった。画像上は胸壁腫瘍も鑑別に含まれたが、CA19-9値の漸増がみられ、膵癌肋骨転移を疑った。局所制御目的に胸壁腫瘍切除再建を施行した。術後CA19-9値は速やかに低下した。病理は腫瘍細胞が既存の骨組織に浸潤する形で腺管状に増殖しており、以前の膵癌と類似した組織像であり、膵癌骨転移の診断であった。膵癌は予後不良で、骨転移の切除報告もないが、原発巣の制御が良好で、転移巣の増大が緩序かつ孤立性であれば、切除も治療の一つとして妥当であると考える。(著者抄録), (NPO)日本呼吸器外科学会, 日本語

【肺・胸腺神経内分泌腫瘍の治療】定型カルチノイドの治療
氏家 秀樹, 樋田 泰浩, 大塚 慎也, 佐々木 明洋, 山崎 洋, 藤原 晶, 加藤 達哉, 加賀 基知三, 若狭 哲, 松野 吉宏, 日本外科学会雑誌, 122, 1, 18, 25, 2021年01月, ［査読有り］, ［筆頭著者, 責任著者］
定型カルチノイドは低悪性度(高分化型)な肺神経内分泌腫瘍(Neuroendocrine neoplasms、NEN)であり、比較的緩徐に増大し、胸部外の臓器に転移することはほとんどないとされている。本邦の2018年度肺癌診療ガイドライン、およびNational Comprehensive Cancer Network(NCCN)ガイドラインによると、カルチノイドの治療は、カルチノイドの種類(定型、異型)および腫瘍の進展度(切除可否)に大きく依存する。一般的に、切除可能な限局型のカルチノイド腫瘍は、非小細胞肺癌と同様に肺葉切除術および縦隔リンパ節郭清術で治癒し、他の治療を必要としない。定型カルチノイドでは、異型カルチノイドと比べてリンパ節転移の可能性も低く、十分な切除断端が確保できれば、気管支管状切除などの肺温存手術を試みることができる。稀に切除不能な定型カルチノイドが存在するが、緩徐に成長する傾向があり、化学療法と放射線治療の利点は不明であるため、経過観察になることも多い。ソマトスタチンレセプター陽性例に対しては、ソマトスタチンアナログによる治療を考慮する。以上より、カルチノイドの治療は、カルチノイドの種類、および腫瘍の進展度に大きく依存するため、適切な病期・病理診断が重要である。(著者抄録), (一社)日本外科学会, 日本語

肺移植後に発症したα-グルコシダーゼ阻害薬内服中の腸管嚢胞様気腫症の一例
大塚慎也, 大塚慎也, 氏家秀樹, 加藤達哉, 千葉龍平, 椎谷洋彦, 藤原晶, 樋田泰浩, 加賀基知三, 若狭哲, 井上玲, 飯村泰昭, 日本肺および心肺移植研究会プログラム・抄録集, 37th, 1, 103, 103, 2021年
(一社)日本移植学会, 日本語

劣性栄養障害性表皮水疱症に対するCRISPR/Cas9を用いた効率的な遺伝子リフレーミング療法(Efficient gene reframing therapy for recessive dystrophic epidermolysis bullosa with CRISPR/Cas9)　　　　　　　　　　　　　　　
Takashima Shota, Shinkuma Satoru, Fujita Yasuyuki, Nomura Toshifumi, Ujiie Hideyuki, Natsuga Ken, Iwata Hiroaki, Nakamura Hideki, Vorobyev Artem, Abe Riichiro, Shimizu Hiroshi, 日本研究皮膚科学会年次学術大会・総会プログラム, 45回, 102, 102, 2020年11月
(一社)日本研究皮膚科学会, 英語

毛包幹細胞の娘細胞は皮膚発達のかわりに表皮下水疱を修復する(Hair follicle stem cell progeny repair subepidermal blisters at the expense of skin development)　　　　　　　　　　　　　　　
Fujimura Yu, Watanabe Mika, Ohno Kota, Kobayashi Yasuaki, Nakamura Hideki, Lauria Andrea, Proserpio Valentina, Ujiie Hideyuki, Iwata Hiroaki, Nishie Wataru, Nagayama Masaharu, Oliviero Salvatore, Donati Giacomo, Shimizu Hiroshi, Natsuga Ken, 日本研究皮膚科学会年次学術大会・総会プログラム, 45回, 180, 180, 2020年11月
(一社)日本研究皮膚科学会, 英語

肺癌に対するセンチネルリンパ節生検(Sentinel lymph node biopsy for lung cancer)
Gregor Alexander, Ujiie Hideki, Yasufuku Kazuhiro, General Thoracic and Cardiovascular Surgery, 68, 10, 1061, 1078, 2020年10月
シュプリンガー・ジャパン(株), 英語

巨大縦隔腫瘍患者における超長尺Montgomery Tチューブの新規挿入法(A Novel Insertion Technique for the Extra-Long Montgomery T-Tube in Patients with a Large Mediastinal Tumor)
Kato Tatsuya, Fujiwara-Kuroda Aki, Shiina Nobuyuki, Aragaki Masato, Ujiie Hideki, Hida Yasuhiro, Kaga Kichizo, Annals of Thoracic and Cardiovascular Surgery, 26, 5, 294, 297, 2020年10月
症例は10代女性で、神経線維腫症I型(レックリングハウゼン病)の既往があった。突然の呼吸困難のため救急医療部へ搬送された。気管挿管後の管理を目的に当院へ紹介された。縦隔腫瘍は気管を圧排しており、気道狭窄による心停止をこれまでに度々経験していた。気道周囲の縦隔腫瘍に対して腫瘍縮小術を施行した。術後に抜管した際に声門下腔狭窄が突然出現し、呼吸困難から心停止に陥った。即時的に再挿管した後に気管切開術を施行した。機械的人工呼吸管理を1ヵ月間施行した後に、気管狭窄に対してMontgomery Tチューブの挿入を施行した。CT検査により狭窄部位の長さを計測し、超長尺のMontgomery Tチューブを特注した。Montgomery Tチューブは柔軟性が高いため、近位端の留置が困難であった。そこで新規の挿入法として、Tチューブの気管孔側端から1号絹糸を挿入し、次いでジェットスタイレットを気管チューブ内に挿入した。神経線維腫症は軟性で、最初の手術で腫瘍が縮小していたため、気管チューブの挿入は容易であった。ジェットスタイレットを1号絹糸に装着し、引き上げて声門下に留置した。現在は3ヵ月毎に同技法によりTチューブを交換している。, 「Annals of Thoracic and Cardiovascular Surgery」編集委員会, 英語

降下性壊死性縦隔炎に対する大動脈弓部トンネリングによる左上縦隔ドレナージ
藤原 晶, 大塚 慎也, 山崎 洋, 佐々木 明洋, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 日本外科感染症学会雑誌, 17, 5, 482, 482, 2020年10月
(一社)日本外科感染症学会, 日本語

非触知肺病変に対するVATS ハイブリッド手術室での切除断端のマーキング、切除、確認法(MaRCH)(VATS for an unpalpable lung tumor, Marking, Resection and Confirmation of the surgical margin at the Hybrid operating room(MaRCH))　　　　　　　　　　　　　　　
Hida Yasuhiro, Kaga Kichizo, Kato Tatsuya, Fujiwara Aki, Shiina Nobuyuki, Ujiie Hideki, Sasaki Akihiro, Yamasaki Hiroshi, 日本呼吸器外科学会雑誌, 34, 3, IS2, 1, 2020年08月
(一社)日本呼吸器外科学会, 英語

イメージガイド下センチネルリンパ節マッピングのためのマルチモーダルなナノスケール薬(A multi-modal nanoscale agent for image-guided sentinel lymph node mapping)　　　　　　　　　　　　　　　
Ujiie Hideki, Chan Harley, Gregor Alexander, Motooka Yamato, Inage Terunaga, Aragaki Masato, Kato Tatsuya, Hida Yasuhiro, Kaga Kichizo, Waddell Thomas K, Keshavjee Shaf, Yasufuku Kazuhiro, 日本呼吸器外科学会雑誌, 34, 3, IS2, 2, 2020年08月
(一社)日本呼吸器外科学会, 英語

両側横隔神経、左反回神経切除、左浅深頸部・腋窩リンパ節、中葉肺転移摘除を行ったIV期胸腺カルチノイドの1例
樋田 泰浩, 加賀 基知三, 加藤 達哉, 藤原 晶, 椎名 伸行, 氏家 秀樹, 佐々木 明洋, 山崎 洋, 日本呼吸器外科学会雑誌, 34, 3, SP3, 3, 2020年08月
(NPO)日本呼吸器外科学会, 日本語

超細径ファイバースコープを用いた末梢気道発生肺癌に対する経気管支鏡的PTT　　　　　　　　　　　　　　　
木下 智成, 岡 潔, 石綿 司, 稲毛 輝長, 本岡 大和, 氏家 秀樹, 皆川 佐知子, 淺村 尚生, 安福 和弘, 日本呼吸器外科学会雑誌, 34, 3, RO4, 5, 2020年08月
(NPO)日本呼吸器外科学会, 日本語

ドライバー遺伝子陽性c-stage IV肺癌患者に対する外科手術の意義　　　　　　　　　　　　　　　
加藤 達哉, 椎名 伸行, 藤原 晶, 氏家 秀樹, 佐々木 明洋, 山崎 洋, 樋田 泰浩, 加賀 基知三, 日本呼吸器外科学会雑誌, 34, 3, RO10, 7, 2020年08月
(NPO)日本呼吸器外科学会, 日本語

二窓法および細径光学視管を用いた一窓法によるReduced port surgeryと将来の展望　　　　　　　　　　　　　　　
加賀 基知三, 樋田 泰浩, 加藤 達哉, 藤原 晶, 氏家 秀樹, 佐々木 明洋, 山崎 洋, 日本呼吸器外科学会雑誌, 34, 3, O36, 5, 2020年08月
(NPO)日本呼吸器外科学会, 日本語

単孔式胸腔鏡への移行を念頭に置いた胸腔鏡手術の分類とトレーニング法　　　　　　　　　　　　　　　
樋田 泰浩, 加賀 基知三, 加藤 達哉, 藤原 晶, 椎名 伸行, 氏家 秀樹, 佐々木 明洋, 山崎 洋, 日本呼吸器外科学会雑誌, 34, 3, MO2, 1, 2020年08月
(NPO)日本呼吸器外科学会, 日本語

4D-CTにより術前に右房浸潤の有無を予測できた胸腺腫瘍の一例　　　　　　　　　　　　　　　
山崎 洋, 樋田 泰浩, 佐々木 明洋, 椎名 伸行, 藤原 晶, 氏家 秀樹, 加藤 達哉, 加賀 基知三, 日本呼吸器外科学会雑誌, 34, 3, MO26, 5, 2020年08月
(NPO)日本呼吸器外科学会, 日本語

手術可能な肺がんに対する術後のモニタリングとしてのctDNA測定の有用性の検証　　　　　　　　　　　　　　　
加藤 達哉, Low Siew-Kee, 清谷 一馬, 中村 透, 藤原 晶, 氏家 秀樹, 椎名 伸行, 樋田 泰浩, 加賀 基知三, 中村 祐輔, 日本呼吸器外科学会雑誌, 34, 3, MO27, 2, 2020年08月
(NPO)日本呼吸器外科学会, 日本語

手術介入を要した胸部外傷の検討　　　　　　　　　　　　　　　
佐々木 明洋, 山崎 洋, 椎名 伸行, 氏家 秀樹, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 日本呼吸器外科学会雑誌, 34, 3, MO60, 9, 2020年08月
(NPO)日本呼吸器外科学会, 日本語

出産を契機に生じた奇静脈瘤内血栓に対し緊急手術を施行した1例　　　　　　　　　　　　　　　
椎名 伸行, 加藤 達哉, 佐々木 明洋, 山崎 洋, 藤原 晶, 氏家 秀樹, 樋田 泰浩, 福井 秀章, 松野 吉宏, 加賀 基知三, 日本呼吸器外科学会雑誌, 34, 3, MO64, 4, 2020年08月
(NPO)日本呼吸器外科学会, 日本語

低侵襲性超音波気管支鏡ガイド下経気管支穿刺(EBUS-TBNI)を用いる,中心肺動脈塞栓症に対する直接的血栓溶解法の開発:ブタでの前臨床実験
INAGE Terunaga, FUJINO Kosuke, MOTOOKA Yamato, ISHIWATA Tsukasa, GREGOR Alexander, UJIIE Hideki, BERNARDS Nicholas, CHEN Zhenchian, ARAGAKI Masato, EFFAT Andrew, YOSHINO Ichiro, YASUFUKU Kazuhiro, 日本外科学会定期学術集会(Web), 120回, SF, 6:[T], 2020年08月
(一社)日本外科学会, 英語

非触知肺病変に対するVATS ハイブリッド手術室での切除断端の作成、切除、確認法(MaRCH)(VATS for an unpalpable lung tumor, Marking, Resection and Confirmation of the surgical margin at the Hybrid operating room(MaRCH))　　　　　　　　　　　　　　　
Hida Yasuhiro, Kaga Kichizo, Kato Tatsuya, Fujiwara Aki, Shiina Nobuyuki, Ujiie Hideki, Sasaki Akihiro, Yamasaki Hiroshi, 日本呼吸器外科学会雑誌, 34, 3, IS2, 1, 2020年08月
(NPO)日本呼吸器外科学会, 英語

イメージガイド下センチネルリンパ節マッピングのためのマルチモーダルなナノスケール薬(A multi-modal nanoscale agent for image-guided sentinel lymph node mapping)　　　　　　　　　　　　　　　
Ujiie Hideki, Chan Harley, Gregor Alexander, Motooka Yamato, Inage Terunaga, Aragaki Masato, Kato Tatsuya, Hida Yasuhiro, Kaga Kichizo, Waddell Thomas K, Keshavjee Shaf, Yasufuku Kazuhiro, 日本呼吸器外科学会雑誌, 34, 3, IS2, 2, 2020年08月
(NPO)日本呼吸器外科学会, 英語

両側横隔神経、左反回神経切除、左浅深頸部・腋窩リンパ節、中葉肺転移摘除を行ったIV期胸腺カルチノイドの1例
樋田 泰浩, 加賀 基知三, 加藤 達哉, 藤原 晶, 椎名 伸行, 氏家 秀樹, 佐々木 明洋, 山崎 洋, 日本呼吸器外科学会雑誌, 34, 3, SP3, 3, 2020年08月
(NPO)日本呼吸器外科学会, 日本語

非典型的な先天性嚢胞性肺疾患
加賀 基知三, 大塚 慎也, 佐々木 明洋, 山崎 洋, 氏家 秀樹, 藤原 晶[黒田], 加藤 達哉, 樋田 泰浩, 若狭 哲, 日本気胸・嚢胞性肺疾患学会雑誌, 20, 1, 69, 69, 2020年08月
日本気胸・嚢胞性肺疾患学会, 日本語

智と技の伝承(鏡視外科手術トレーニングの将来像) ドライラボ、カダバーを用いた単孔式胸腔鏡手術(Uniportal VATS)トレーニングの経験
藤原 晶, 大塚 慎也, 山崎 洋, 佐々木 明洋, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲, 小切開・鏡視外科学会雑誌, 11, 1, 38, 38, 2020年06月
(NPO)小切開・鏡視外科学会, 日本語

先天性肺嚢胞性疾患に対する胸腔鏡手術の適応と成績
加賀 基知三, 大塚 慎也, 佐々木 明洋, 山崎 洋, 氏家 秀樹, 藤原 晶[黒田], 加藤 達哉, 樋田 泰浩, 若狭 哲, 小切開・鏡視外科学会雑誌, 11, 1, 50, 50, 2020年06月
(NPO)小切開・鏡視外科学会, 日本語

有茎肋間筋弁による胸腔鏡下気管支断端被覆の検討
山崎 洋, 加賀 基知三, 大塚 慎也, 佐々木 明洋, 氏家 秀樹, 藤原 晶, 加藤 達也, 樋田 泰浩, 若狭 哲, 小切開・鏡視外科学会雑誌, 11, 1, 57, 57, 2020年06月
(NPO)小切開・鏡視外科学会, 日本語

胸腔鏡下手術における下位肋間経路による新しい切除肺の創外摘出法(eXtraction of resecting specimens through the Lower INterCostal route(XLINC) method、XLINC)について
佐々木 明洋, 大塚 慎也, 山崎 洋, 氏家 秀樹, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 小切開・鏡視外科学会雑誌, 11, 1, 58, 58, 2020年06月
(NPO)小切開・鏡視外科学会, 日本語

大網弁の積極利用による膿胸の治療と予防
樋田 泰浩, 加賀 基知三, 加藤 達哉, 藤原 晶, 椎名 伸行, 氏家 秀樹, 佐々木 明洋, 山崎 洋, 気管支学, 42, Suppl., S179, S179, 2020年06月
(NPO)日本呼吸器内視鏡学会, 日本語

挿入性の優れたファイバースコープを用いた末梢気道発生肺癌に対する経気管支鏡的PTT
木下 智成, 岡 潔, 石綿 司, 稲毛 輝長, 本岡 大和, 氏家 秀樹, 皆川 佐知子, 安福 和弘, 気管支学, 42, Suppl., S183, S183, 2020年06月
(NPO)日本呼吸器内視鏡学会, 日本語

超音波気管支鏡を併用した血栓溶解療法に関する基礎研究
稲毛 輝長, 藤野 孝介, 石綿 司, 本岡 大和, 氏家 秀樹, 新垣 雅人, 関 健史, 吉野 一郎, 安福 和弘, 気管支学, 42, Suppl., S274, S274, 2020年06月
(NPO)日本呼吸器内視鏡学会, 日本語

【小児の先天性嚢胞性肺疾患に対する胸腔鏡手術】
加賀 基知三, 樋田 泰浩, 加藤 達哉, 藤原 晶[黒田], 椎名 伸行, 氏家 秀樹, 佐々木 明洋, 山崎 洋, 若狭 哲, 北海道外科雑誌, 65, 1, 2, 7, 2020年06月
先天性嚢胞性肺疾患で最も頻度の高い先天性肺気道奇形は、出生時の呼吸障害やその後の肺炎の併発のために外科的治療の対象となる。無症候性の先天性肺気道奇形の手術適応や適切な手術時期は明確ではない。一方、小児に対する胸腔鏡手術は低侵襲であると報告されているものの、成人と比較すると難易度は高い。小児に対する胸腔鏡手術が広く行われるようになると、適切な手術時期の決定はさらに複雑になるだろう。本疾患はまれな疾患であり、臨床的に小児外科と呼吸器外科の間(はざま)に存在するため、両領域の協力が必要である。本稿では現時点での論点を概説する。(著者抄録), 北海道外科学会, 日本語

大きな縦隔腫瘍患者における超長Montgomery Tチューブの新規挿入法
Kato Tatsuya, Fujiwara-Kuroda Aki, Shiina Nobuyuki, Aragaki Masato, Ujiie Hideki, Hida Yasuhiro, Kaga Kichizo, Annals of Thoracic and Cardiovascular Surgery (Web), 26, 5, 2020年

肺移植患者における超音波気管支鏡の安全性および有効性の検討
氏家 秀樹, 加藤 達哉, 稲毛 輝長, 石綿 司, 新垣 雅人, 樋田 泰浩, 加賀 基知三, 若狭 哲, 移植, 55, Supplement, 383_2, 383_2, 2020年
目的 気管支腔内超音波検査法（EBUS）は低侵襲かつ高い診断能を有する検査手技である。本研究では、肺移植待機患者および移植後患者の経過中に、悪性腫瘍が疑われた肺・リンパ節病変に対するEBUSの有用性を検討した。方法 2008年～2018年までの間にEBUSガイド下経気道的肺生検 (EBUS-GS-TBB, EBUS-TBNA)が施行された肺移植後患者及び待機患者に対し後方視的検討を行った。結果 全28例に対してEBUS-TBNA：20例、EBUS-GS-TBB：8例 が施行された。肺移植術後患者19例の内訳は、移植後に肺腫瘤を認め悪性腫瘍が疑われた11例、肺門及び縦隔リンパ節腫大を認め移植後リンパ増殖性疾患(PTLD)が疑われた8例であった。全症例において確定診断が可能であり、重篤な合併症を認めなかった。診断の内訳は、原発性肺癌6例、PTLD 4例、感染性疾患3例、良性疾患6例であった。PTLDが疑われた8例中、4例（50%）がPTLDと診断され、肺悪性腫瘍が疑われた11例中、6例(55%)で肺悪性腫瘍の確定診断が可能であった。また、肺移植待機9例のうち、5例（56%）にて肺悪性腫瘍の確定診断に至り、治療方針が変更された。結論 移植待機中の末期慢性肺疾患症例及び肺移植術前後症例におけるEBUSは、肺病変及び縦隔肺門リンパ節に対する安全かつ高精度な質的診断が可能な検査法と考えられた。, 一般社団法人 日本移植学会, 日本語

肺移植患者におけるEBUS(超音波気管支鏡)の役割
氏家秀樹, 氏家秀樹, 加藤達哉, 稲毛輝長, 石綿司, 新垣雅人, 新垣雅人, 樋田泰浩, 加賀基知三, KESHAVJEE Shaf, YASUFUKU Kazuhiro, 日本肺および心肺移植研究会プログラム・抄録集, 36th, 4, 484, 484, 2020年
(一社)日本移植学会, 日本語

肺メディカルコンサルタント業務の肺移植外科医以外への委嘱の展望
樋田泰浩, 加賀基知三, 加藤達哉, 藤原晶, 椎名伸行, 氏家秀樹, 佐々木明洋, 山崎洋, 大岡智学, 日本肺および心肺移植研究会プログラム・抄録集, 36th, 4, 504, 504, 2020年
(一社)日本移植学会, 日本語

降下性壊死性縦隔炎に対する大動脈弓部トンネリングによる左上縦隔ドレナージ
藤原晶, 大塚慎也, 山崎洋, 佐々木明洋, 氏家秀樹, 加藤達哉, 樋田泰浩, 加賀基知三, 日本外科感染症学会雑誌(Web), 17, 5, 2020年

ヘッドマウントディスプレイ(HMD)によるバーチャル・リアリティー(VR)システムを用いた,肺区域切除手術シミュレーション法の開発
氏家秀樹, 大塚慎也, 佐々木明洋, 山崎洋, 藤原晶, 加藤達哉, 樋田泰浩, 加賀基知三, 若狭哲, 日本胸部外科学会定期学術集会(Web), 73rd, LOO13, 12, 2020年
(一社)日本胸部外科学会, 日本語

気管ステント留置後の逸脱に対し気管形成術を行い救命できた外傷性気管損傷の一例
大塚慎也, 加藤達哉, 氏家秀樹, 山崎洋, 佐々木明洋, 藤原晶, 樋田泰浩, 加賀基知三, 若狭哲, 高島雄太, 品川尚文, 日本胸部外科学会定期学術集会(Web), 73rd, LCPA1, 10, 2020年
(一社)日本胸部外科学会, 日本語

超細径ファイバースコープを用いた末梢気道発生肺癌に対する経気管支鏡的PTT
木下智成, 木下智成, 岡潔, 石綿司, 稲毛輝長, 本岡大和, 氏家秀樹, 皆川佐知子, 淺村尚生, 安福和弘, 日本呼吸器外科学会総会(Web), 37th, 3, RO4, 5, 2020年
(NPO)日本呼吸器外科学会, 日本語

ドライバー遺伝子陽性c-stage IV肺癌患者に対する外科手術の意義
加藤達哉, 椎名伸行, 藤原晶, 氏家秀樹, 佐々木明洋, 山崎洋, 樋田泰浩, 加賀基知三, 日本呼吸器外科学会総会(Web), 37th, 3, RO10, 7, 2020年
(NPO)日本呼吸器外科学会, 日本語

二窓法および細径光学視管を用いた一窓法によるReduced port surgeryと将来の展望
加賀基知三, 樋田泰浩, 加藤達哉, 藤原晶, 氏家秀樹, 佐々木明洋, 山崎洋, 日本呼吸器外科学会総会(Web), 37th, 3, O36, 5, 2020年
(NPO)日本呼吸器外科学会, 日本語

単孔式胸腔鏡への移行を念頭に置いた胸腔鏡手術の分類とトレーニング法
樋田泰浩, 加賀基知三, 加藤達哉, 藤原晶, 椎名伸行, 氏家秀樹, 佐々木明洋, 山崎洋, 日本呼吸器外科学会総会(Web), 37th, 3, MO2, 1, 2020年
(NPO)日本呼吸器外科学会, 日本語

4D-CTにより術前に右房浸潤の有無を予測できた胸腺腫瘍の一例
山崎洋, 樋田泰浩, 佐々木明洋, 椎名伸行, 藤原晶, 氏家秀樹, 加藤達哉, 加賀基知三, 日本呼吸器外科学会総会(Web), 37th, 3, MO26, 5, 2020年
(NPO)日本呼吸器外科学会, 日本語

手術可能な肺がんに対する術後のモニタリングとしてのctDNA測定の有用性の検証
加藤達哉, LOW Siew-Kee, 清谷一馬, 中村透, 藤原晶, 氏家秀樹, 椎名伸行, 樋田泰浩, 加賀基知三, 中村祐輔, 日本呼吸器外科学会総会(Web), 37th, 3, MO27, 2, 2020年
(NPO)日本呼吸器外科学会, 日本語

手術介入を要した胸部外傷の検討
佐々木明洋, 山崎洋, 椎名伸行, 氏家秀樹, 藤原晶, 加藤達哉, 樋田泰浩, 加賀基知三, 日本呼吸器外科学会総会(Web), 37th, 3, MO60, 9, 2020年
(NPO)日本呼吸器外科学会, 日本語

出産を契機に生じた奇静脈瘤内血栓に対し緊急手術を施行した1例
椎名伸行, 加藤達哉, 佐々木明洋, 山崎洋, 藤原晶, 氏家秀樹, 樋田泰浩, 福井秀章, 松野吉宏, 加賀基知三, 日本呼吸器外科学会総会(Web), 37th, 3, MO64, 4, 2020年
(NPO)日本呼吸器外科学会, 日本語

小児の先天性嚢胞性肺疾患に対する胸腔鏡手術
加賀基知三, 樋田泰浩, 加藤達哉, 藤原(黒田)晶, 椎名伸行, 氏家秀樹, 佐々木明洋, 山崎洋, 若狭哲, 北海道外科雑誌, 65, 1, 2, 7, 2020年
先天性嚢胞性肺疾患で最も頻度の高い先天性肺気道奇形は、出生時の呼吸障害やその後の肺炎の併発のために外科的治療の対象となる。無症候性の先天性肺気道奇形の手術適応や適切な手術時期は明確ではない。一方、小児に対する胸腔鏡手術は低侵襲であると報告されているものの、成人と比較すると難易度は高い。小児に対する胸腔鏡手術が広く行われるようになると、適切な手術時期の決定はさらに複雑になるだろう。本疾患はまれな疾患であり、臨床的に小児外科と呼吸器外科の間(はざま)に存在するため、両領域の協力が必要である。本稿では現時点での論点を概説する。(著者抄録), 北海道外科学会, 日本語

超音波気管支鏡を併用した血栓溶解療法に関する基礎研究
稲毛輝長, 稲毛輝長, 藤野孝介, 石綿司, 本岡大和, 氏家秀樹, 新垣雅人, 関健史, 吉野一郎, 安福和弘, 気管支学, 42, Suppl., S274, S274, 2020年
(NPO)日本呼吸器内視鏡学会, 日本語

肺移植患者における超音波気管支鏡の安全性および有効性の検討
氏家秀樹, 加藤達哉, 稲毛輝長, 石綿司, 新垣雅人, 樋田泰浩, 加賀基知三, 若狭哲, KESHAVJEE Shaf, YASUFUKU Kazuhiro, 日本移植学会総会プログラム抄録集, 56th, 総会臨時, 383, 383, 2020年
(一社)日本移植学会, 日本語

大網弁の積極利用による膿胸の治療と予防
樋田泰浩, 加賀基知三, 加藤達哉, 藤原晶, 椎名伸行, 氏家秀樹, 佐々木明洋, 山崎洋, 気管支学, 42, Suppl., S179, S179, 2020年
(NPO)日本呼吸器内視鏡学会, 日本語

挿入性の優れたファイバースコープを用いた末梢気道発生肺癌に対する経気管支鏡的PTT
木下智成, 岡潔, 石綿司, 稲毛輝長, 本岡大和, 氏家秀樹, 皆川佐知子, 安福和弘, 気管支学, 42, Suppl., S183, S183, 2020年
(NPO)日本呼吸器内視鏡学会, 日本語

腫瘍親和性ナノ粒子を用いた末梢肺癌の診断,治療戦略
木下智成, 木下智成, 氏家秀樹, 本岡大和, 稲毛輝長, 石綿司, 淺村尚生, 安福和弘, 気管支学, 41, Suppl., S201, S201, 2019年06月01日
(NPO)日本呼吸器内視鏡学会, 日本語

末梢小型肺病変の同定およびマッピング Phase I臨床試験 Cone-beam CTガイド下microcoil留置による胸腔鏡下末梢小型肺腫瘍切除
木下 智成, 氏家 秀樹, 稲毛 輝長, 本岡 大和, 石綿 司, 淺村 尚生, 安福 和弘, 気管支学, 41, Suppl., S165, S165, 2019年06月
(NPO)日本呼吸器内視鏡学会, 日本語

末梢肺結節の診断における仮想的4-D電磁先端追跡装置と気管支内超音波造影の併用検査に関する予備的研究(Pilot Study using Combined Virtual 4-D Electromagnetic Tip-Tracked Devices and Endobronchial Ultrasound in the Diagnosis of Peripheral Pulmonary Nodules)
Ishiwata Tsukasa, Ujiie Hideki, Gregor Alexander, Motooka Yamato, Inage Terunaga, Kinoshita Tomonari, Chen Ken, Tatsumi Koichiro, Yasufuku Kazuhiro, 日本呼吸器学会誌, 8, 増刊, 369, 369, 2019年03月
(一社)日本呼吸器学会, 英語

末梢肺結節の診断におけるバーチャル4D電磁気チップ追跡デバイスと気管支内超音波の併用によるパイロット研究
ISHIWATA Tsukasa, ISHIWATA Tsukasa, UJIIE Hideki, GREGOR Alexander, MOTOOKA Yamato, INAGE Terunaga, KINOSHITA Tomonari, CHEN Ken, TATSUMI Koichiro, YASUFUKU Kazuhiro, 日本呼吸器学会誌(Web), 8, 2019年

挿入性の優れたファイバースコープを用いた末梢気道発生肺癌に対する経気管支鏡的PTT
木下智成, 木下智成, 岡潔, 石綿司, 稲毛輝長, 本岡大和, 氏家秀樹, 皆川佐知子, 淺村尚生, 安福和弘, 日本レーザー医学会誌, 40, 3, 246, 246, 2019年
(NPO)日本レーザー医学会, 日本語

腫瘍親和性ナノ粒子を用いた末梢肺癌の診断,治療戦略
木下智成, 木下智成, 氏家秀樹, 本岡大和, 稲毛輝長, 石綿司, 淺村尚生, 安福和弘, 気管支学, 41, Suppl., S201, S201, 2019年
(NPO)日本呼吸器内視鏡学会, 日本語

Phase I臨床試験:Cone-beam CTガイド下microcoil留置による胸腔鏡下末梢小型肺腫瘍切除
木下智成, 木下智成, 氏家秀樹, 稲毛輝長, 本岡大和, 石綿司, 淺村尚生, 安福和弘, 気管支学, 41, Suppl., S165, S165, 2019年
(NPO)日本呼吸器内視鏡学会, 日本語

ヒトの肺組織に含まれる肺腫瘍のex vivoにおける超音波高周波スペクトラム分析(SPECTRUM ANALYSIS OF ULTRASOUND RADIOFREQUENCY OF LUNG TUMOR IN EX-VIVO HUMAN LUNGS)　　　　　　　　　　　　　　　
Inage Terunaga, Ujiie Hideki, Gregor Alexander, Motooka Yamato, Kinoshita Tomonari, Lee ChangYoung, Fujino Kosuke, Yoshino Ichiro, Yasufuku Kazuhiro, 日本呼吸器外科学会雑誌, 32, 3, IS3, 3, 2018年04月
(NPO)日本呼吸器外科学会, 英語

Tronto general hospitalにおける小型肺結節に関する胸腔鏡を用いた新規位置特定法(A novel thoracoscopic localization technique of small pulmonary nodules at Toronto general hospital)　　　　　　　　　　　　　　　
Ujiie Hideki, Kato Tatsuya, Fujino Kosuke, Igai Hitoshi, Waddell Thomas K., Keshavjee Shaf, 日本外科学会定期学術集会抄録集, 117回, SF, 1, 2017年04月
(一社)日本外科学会, 英語

EBUS-TBNAによる遺伝子解析に基づいたsiRNA-nanoparticleによる肺癌個別化治療法の確立
加藤達哉, 氏家秀樹, 藤野孝介, 加地苗人, CHEN Juan, ZHENG Gang, 加賀基知三, 松居喜郎, 安福和弘, 日本外科学会定期学術集会(Web), 117th, SF, 8, 2017年
(一社)日本外科学会, 日本語

悪性胸膜中皮腫における治療標的遺伝子としてのSORORINおよびPLK1遺伝子の役割
加藤達哉, 加藤達哉, LEE Daiyoon, 氏家秀樹, 和田啓伸, 加地苗人, 松毛真一, 菅野宏美, 畑中豊, 畑中佳奈子, 松野吉宏, 加賀基知三, 松居喜郎, DE PERROT Marc, 安福和弘, 日本呼吸器外科学会総会(Web), 34th, 3, P67, 3, 2017年
(NPO)日本呼吸器外科学会, 日本語

局所進行非小細胞癌に対する三者併用療法の研究
秋山博彦, 木下裕康, 中島由貴, 氏家秀樹, 酒井洋, 栗本太嗣, 須藤淳子, 山根由紀, 山名一平, 高橋聡, 齊藤吉弘, 埼玉県立がんセンター年報, 37, 47, 2014年
日本語

非小細胞肺癌におけるBiomarkerの検討 血清中のHGF(Hepatocyte growth factor)および,IL-6はStage III非小細胞肺癌において,有効なBiomarkerである。
氏家秀樹, 秋山博彦, 冨田幹夫, 埼玉県立がんセンター年報, 37, 47, 48, 2014年
日本語

頭頚部領域からの肺転移の検討
中島由貴, 秋山博彦, 木下裕康, 氏家秀樹, 埼玉県立がんセンター年報, 37, 47, 2014年
日本語

個別化医療(パーソナル医療)を目指したがんの遺伝子診療に関する研究
赤木究, 新井吉子, 高橋修平, 角田美穂, 高橋朱実, 立川哲彦, 山口研成, 大木暁, 朝山雅子, 原浩樹, 八岡利昌, 西村洋治, 川島吉之, 坂本裕彦, 田中洋一, 酒井洋, 栗本太嗣, 須藤淳子, 山根由紀, 山名一平, 秋山博彦, 岡田大輔, 中島由貴, 氏家秀樹, 埼玉県立がんセンター年報, 37, 56, 2014年
日本語

肺腫瘤との鑑別を要した,縦隔発生海綿状血管腫の1例
氏家秀樹, 岡田大輔, 中島由貴, 木下裕康, 秋山博彦, 日本胸腺研究会プログラム・抄録集, 32nd, 78, 2013年
日本語

個別化医療(オーダーメイド医療)を目指したがんの遺伝子診療に関する研究
赤木究, 新井吉子, 望月孝一, 角田美穂, 高橋朱実, 山口研成, 門脇重憲, 朝山雅子, 大木暁, 原浩樹, 八岡利昌, 西村洋治, 坂本裕彦, 田中洋一, 酒井洋, 栗本太嗣, 須藤淳子, 水谷英明, 山名一平, 秋山博彦, 岡田大輔, 中島由貴, 氏家秀樹, 埼玉県立がんセンター年報, 36, 54, 2013年
日本語

肺がんの予後マーカーとしてのサイトカイン
冨田幹夫, 氏家秀樹, 中島由貴, 岡田大輔, 吉野直之, 秋山博彦, 埼玉県立がんセンター年報, 36, 129, 130, 2013年
日本語

局所進行非小細胞癌に対する三者併用療法の研究
秋山博彦, 岡田大輔, 中島由貴, 氏家秀樹, 酒井洋, 栗本太嗣, 水谷英明, 須藤淳子, 山名一平, 齊藤吉弘, 埼玉県立がんセンター年報, 36, 47, 2013年
日本語

非小細胞肺癌におけるBiomarkerの検討 血清中のHGF(Hepatocyte growth factor)および,IL-6はStage III非小細胞肺癌において,有効なBiomarkerである。
氏家秀樹, 岡田大輔, 秋山博彦, 冨田幹夫, 埼玉県立がんセンター年報, 36, 46, 2013年
日本語

EGFR遺伝子変異を伴う術後再発肺がん症例の検討-パラフィン包埋外科切除標本からEGFR変異を測定した肺癌症例の検討
岡田大輔, 秋山博彦, 中島由貴, 氏家秀樹, 埼玉県立がんセンター年報, 36, 47, 2013年
日本語

原発性肺癌におけるリンパ管侵襲の評価染色法での比較,grading systemの検討
中島由貴, 秋山博彦, 岡田大輔, 氏家秀樹, 埼玉県立がんセンター年報, 36, 46, 2013年
日本語

PET-CTにて異常集積を認めた、後縦隔発生Castleman病の一例
氏家 秀樹, 岡田 大輔, 中島 由貴, 秋山 博彦, 山名 一平, 水谷 英明, 須藤 淳子, 栗本 太嗣, 酒井 洋, 西村 ゆう, 西田 一典, 気管支学, 34, Suppl., S258, S258, 2012年05月
(NPO)日本呼吸器内視鏡学会, 日本語

縦隔原発Coelomic Cyst(Mesothelial cyst)の1例
氏家秀樹, 岡田大輔, 中島由貴, 秋山博彦, 西村ゆう, 西田一典, 日本胸腺研究会プログラム・抄録集, 31st, 18, 2012年
日本語

他癌術後に診断された原発性肺癌手術症例の検討
岡田大輔, 氏家秀樹, 中島由貴, 秋山博彦, 日本呼吸器外科学会総会(Web), 29th, 3, P12, 08, 2012年
(NPO)日本呼吸器外科学会, 日本語

肺腺癌における,HGF(Hepatocyte Growth Factor)の予後マーカーとしての有用性
氏家秀樹, 岡田大輔, 中島由貴, 秋山博彦, 冨田幹夫, 日本呼吸器外科学会総会(Web), 29th, 3, P85, 01, 2012年
(NPO)日本呼吸器外科学会, 日本語

血中のHGFとNNMTの肺がんにおける臨床的意義の検討:HGFはIII期非小細胞肺がんに有効な予後マーカーである
冨田幹夫, 氏家秀樹, 秋山博彦, 埼玉県立がんセンター年報, 35, 120, 121, 2012年
日本語

PET-CTにて異常集積を認めた,後縦隔発生Castleman病の一例
氏家秀樹, 岡田大輔, 中島由貴, 秋山博彦, 山名一平, 水谷英明, 須藤淳子, 栗本太嗣, 酒井洋, 西村ゆう, 西村ゆう, 西田一典, 気管支学, 34, Suppl., S258, S258, 2012年
(NPO)日本呼吸器内視鏡学会, 日本語

下行結腸癌術後腋窩リンパ節転移の1例
菊地功, 西村洋治, 西田一典, 西村ゆう, 氏家秀樹, 秋山博彦, 塙秀暁, 八岡利昌, 網倉克己, 川島吉之, 坂本裕彦, 黒住昌史, 田中洋一, 癌と化学療法, 39, 12, 2252, 2254, 2012年
消化器の悪性腫瘍の腋窩リンパ節転移はまれである。下行結腸癌術後に左腋窩リンパ節転移を来した1例を経験したので報告する。症例:78歳、女性。既往歴:53歳時右乳癌手術、70歳時胃癌手術。現病歴:2011年4月下行結腸癌によるイレウスに対して、左半結腸切除術(D3)を行った。中分化型腺癌、pSS、pN0、pStage IIで、術後補助化学療法は行わず経過観察していた。術後4ヵ月のCTで、術前から指摘されていた左肺S10の小結節が増大し、2ヶ所の新病変が出現した。さらに左腋窩に11mmに腫大したリンパ節を指摘された。諸検査にて左乳房内に腫瘍性病変はなかったが、左腋窩リンパ節は不整形に腫大し、転移を疑った。転移性肺腫瘍、左腋窩リンパ節転移の診断で、胸腔鏡下左肺部分切除、左腋窩リンパ節を摘出し、ともに中分化型腺癌で下行結腸癌の転移と考えられた。術後、UFT/LV内服を行い、再発の所見はなく経過中である。(著者抄録), (株)癌と化学療法社, 日本語

肺原発形質細胞腫の一切除例
中島由貴, 氏家秀樹, 岡田大輔, 秋山博彦, 日本臨床外科学会雑誌, 73, 12, 3328, 3328, 2012年
日本臨床外科学会, 日本語

低身長症例における完全モニター下胸腔鏡手術の工夫　　　　　　　　　　　　　　　
中島 由貴, 小泉 潔, 原口 修司, 秋山 博彦, 三上 厳, 岡田 大輔, 岡本 淳一, 飯島 慶仁, 氏家 秀樹, 清水 一雄, 日本内視鏡外科学会雑誌, 16, 7, 392, 392, 2011年12月
(一社)日本内視鏡外科学会, 日本語

血中の肝細胞増殖因子(HGF)はIII期非小細胞肺がんに有効な予後マーカーである(Serum hepatocyte growth factor as a prognostic marker for resectable non-small cell lung cancer)　　　　　　　　　　　　　　　
冨田 幹夫, 氏家 秀樹, 秋山 博彦, 日本癌学会総会記事, 70回, 143, 143, 2011年09月
日本癌学会, 英語

左主気管支管状切除術後に重粒子線治療を施行した主気管支腺様嚢胞癌の一例
秋山博彦, 岡田大輔, 吉野直之, 中島由貴, 氏家秀樹, 小泉潔, 馬場雅行, 日本呼吸器外科学会雑誌, 25, 3(Web), P98, 04, 2011年
(NPO)日本呼吸器外科学会, 日本語

Gefitinib投与後,Salvage手術を施行した非小細胞肺癌4症例
岡田大輔, 秋山博彦, 吉野直之, 氏家秀樹, 小泉潔, 清水一雄, 日本呼吸器外科学会雑誌, 25, 3(Web), P35, 02, 2011年
(NPO)日本呼吸器外科学会, 日本語

肺原発淡明細胞腫の一例
氏家秀樹, 吉野直之, 岡田大輔, 秋山博彦, 小泉潔, 清水一雄, 日本呼吸器外科学会雑誌, 25, 3(Web), P42, 06, 2011年
(NPO)日本呼吸器外科学会, 日本語

診断に苦慮した髄外性形質細胞腫の1切除例
氏家秀樹, 中島由貴, 岡田大輔, 秋山博彦, 山名一平, 水谷英明, 栗本太嗣, 酒井洋, 西村ゆう, 久保田靖子, 吉野直之, 小泉潔, 肺癌, 51, 5, 531, 531, 2011年
(NPO)日本肺癌学会, 日本語

進行性胚細胞腫瘍化療後の残存肺転移巣切除例の検討
秋山博彦, 岡田大輔, 中島由貴, 氏家秀樹, 小泉潔, 肺癌, 51, 5, 635, 635, 2011年
(NPO)日本肺癌学会, 日本語

胸腺全摘術後16年目に肺転移を来たしたB3型胸腺腫の1例
氏家秀樹, 櫻井裕幸, 河内利賢, 渡辺俊一, 淺村尚生, 肺癌, 50, 1, 86, 86, 2010年
(NPO)日本肺癌学会, 日本語

乳癌術後孤立性肺転移切除の意義とER,PGR,HER2の発現についての検討
氏家秀樹, 木下貴之, 堀周太郎, 田村宜子, 長尾知哉, 北條隆, 明石定子, 小野麻紀子, 清水千佳子, 蔦幸治, 津田均, 淺村尚生, 日本癌治療学会誌, 45, 2, 556, 556, 2010年
(一社)日本癌治療学会, 日本語

乳がんセンチネルリンパ節における腋窩リンパ節微小転移,ITCsの臨床的意義
堀周太郎, 木下貴之, 氏家秀樹, 田村宜子, 長尾知哉, 明石定子, 北條隆, 津田均, 日本癌治療学会誌, 45, 2, 643, 643, 2010年
(一社)日本癌治療学会, 日本語

腹臥位鏡視下食道切除術における左反回神経リンパ節郭清の工夫　　　　　　　　　　　　　　　
井垣 弘康, 氏家 秀樹, 北村 聡子, 宮田 一志, 日本内視鏡外科学会雑誌, 14, 7, 268, 268, 2009年12月
(一社)日本内視鏡外科学会, 日本語

有茎結腸再建を用いた咽頭喉頭食道全摘術の1例
UJIIE Hideki, SOTOMURA Syuichi, IGAKI Hiroyasu, HITSUKI Yuji, General Thoracic and Cardiovascular Surgery, 57, Supplement, 2009年

成人発症縦隔神経芽細胞腫の1例
氏家秀樹, 中村彰太, 渡邉裕一, 楠本昌彦, 荒井保明, 細野亜古, 牧本敦, 吉田朗彦, 栃木直文, 下田忠和, 肺癌, 49, 1, 133, 133, 2009年
(NPO)日本肺癌学会, 日本語

大腸多重癌症例の検討
岡村淳, 井上弘, 法地聡果, 氏家秀樹, 光山晋一, 武田崇志, 鈴木研裕, 岩渕敏久, 住吉辰朗, 嶋田元, 大東誠司, 柵瀬信太郎, 小野寺久, 鈴木高祐, 日本大腸こう門病学会雑誌, 62, 4, 280, 280, 2009年
(一社)日本大腸肛門病学会, 日本語

塩酸服用による重症腐食性上部消化管炎から縦隔炎・胸膜炎を来たした2例
尾辻 瑞人, 氏家 秀樹, 大多和 正樹, 駒田 謙一, 石松 伸一, 藤田 善幸, 負門 克典, 松迫 正樹, 鈴木 高祐, 気管支学, 30, Suppl., S175, S175, 2008年05月
(NPO)日本呼吸器内視鏡学会, 日本語

小腸イレウス症例における手術適応決定因子の解析
嶋田 元, 小松 一成, 氏家 秀樹, 武田 崇志, 光山 晋一, 鈴木 研祐, 岡村 淳, 岩渕 敏久, 住吉 辰朗, 井上 弘, 大東 誠司, 柵瀬 信太郎, 小野寺 久, 日本外科学会雑誌, 109, 臨増2, 294, 294, 2008年04月
(一社)日本外科学会, 日本語

大腸癌術後の炎症指標が再発予測因子となりうる
鈴木 研裕, 張 成虎, 法地 聡果, 氏家 秀樹, 武田 崇志, 光山 晋一, 岡村 淳, 岩渕 敏久, 住吉 辰朗, 嶋田 元, 井上 弘, 大東 誠司, 柵瀬 信太郎, 小野寺 久, 日本外科学会雑誌, 109, 臨増2, 554, 554, 2008年04月
(一社)日本外科学会, 日本語

Gemcitabineによる膵癌の生存率の改善効果について
井上 弘, 法地 聡果, 光山 晋一, 氏家 秀樹, 武田 崇志, 鈴木 研裕, 岡村 淳, 岩渕 敏久, 住吉 辰朗, 嶋田 元, 大東 誠司, 柵瀬 信太郎, 小野寺 久, 日本外科学会雑誌, 109, 臨増2, 639, 639, 2008年04月
(一社)日本外科学会, 日本語

胃癌穿孔腹膜炎の臨床病理学的検討
井上弘, 法地聡果, 光山晋一, 氏家秀樹, 武田崇志, 鈴木研裕, 岡村淳, 岩渕敏久, 住吉辰朗, 嶋田元, 大東誠司, 柵瀬信太郎, 小野寺久, 日本腹部救急医学会雑誌, 28, 2, 341, 341, 2008年
(一社)日本腹部救急医学会, 日本語

無ガンマグロブリン血症に発症した中葉症候群の1手術例
尾辻瑞人, 大多和正樹, 松藤凡, 平林健, 中村晃子, 細谷亮太, 小澤美和, 鈴木高祐, 小川恵一, 氏家秀樹, 日本呼吸器外科学会雑誌, 22, 3, 568, 568, 2008年
(NPO)日本呼吸器外科学会, 日本語

腎外発育をきたし診断に苦慮した巨大血管筋脂肪腫の1例
氏家秀樹, 小野寺久, 日本臨床外科学会雑誌, 69, 4, 992, 992, 2008年
日本臨床外科学会, 日本語

Gemcitabineによる膵癌の生存率の改善効果について
井上弘, 法地聡果, 光山晋一, 氏家秀樹, 武田崇志, 鈴木研裕, 岡村淳, 岩渕敏久, 住吉辰朗, 嶋田元, 大東誠司, 柵瀬信太郎, 小野寺久, 日本外科学会雑誌, 109, 臨増2, 639, 639, 2008年
(一社)日本外科学会, 日本語

小腸イレウス症例における手術適応決定因子の解析
嶋田元, 小松一成, 氏家秀樹, 武田崇志, 光山晋一, 鈴木研祐, 岡村淳, 岩渕敏久, 住吉辰朗, 井上弘, 大東誠司, 柵瀬信太郎, 小野寺久, 日本外科学会雑誌, 109, 臨増2, 294, 294, 2008年
(一社)日本外科学会, 日本語

大腸癌術後の炎症指標が再発予測因子となりうる
鈴木研裕, 張成虎, 法地聡果, 氏家秀樹, 武田崇志, 光山晋一, 岡村淳, 岩渕敏久, 住吉辰朗, 嶋田元, 井上弘, 大東誠司, 柵瀬信太郎, 小野寺久, 日本外科学会雑誌, 109, 臨増2, 554, 554, 2008年
(一社)日本外科学会, 日本語

塩酸服用による重症腐食性上部消化管炎から縦隔炎・胸膜炎を来たした2例
尾辻瑞人, 氏家秀樹, 大多和正樹, 駒田謙一, 石松伸一, 藤田善幸, 負門克典, 松迫正樹, 鈴木高祐, 気管支学, 30, Suppl., S175, S175, 2008年
(NPO)日本呼吸器内視鏡学会, 日本語

膵頭体部分枝型IPMNに対して膵頭温存膵分節切除術を施行した1例
佐藤渉, 鈴木研祐, 大東誠司, 岩渕敏久, 武田崇志, 法地聡果, 氏家秀樹, 井上弘, 棚瀬信太郎, 小野寺久, 日本臨床外科学会雑誌, 69, 7, 1847, 1847, 2008年
日本臨床外科学会, 日本語

特発性縦隔気腫の臨床学的検討
氏家秀樹, 尾辻瑞人, 大多和正樹, 日本臨床外科学会雑誌, 69, 増刊, 531, 531, 2008年
日本臨床外科学会, 日本語

非定型抗酸菌症を合併した肺癌症例
尾辻 瑞人, 大多和 正樹, 氏家 秀樹, 齋田 幸久, 松迫 正樹, 負門 克典, 蝶名林 直彦, 西村 直樹, 鈴木 高祐, 肺癌, 47, 5, 644, 644, 2007年10月
(NPO)日本肺癌学会, 日本語

当院における縦隔気腫の臨床学的検討　　　　　　　　　　　　　　　
氏家 秀樹, 尾辻 瑞人, 大多和 正樹, 日本気胸・嚢胞性肺疾患学会雑誌, 7, 2, 99, 99, 2007年08月
日本気胸・嚢胞性肺疾患学会, 日本語

消化管gastrointestinal stromal tumor再発・進行症例に対するイマチニブの治療経験
氏家 秀樹, 大東 誠司, 武田 崇志, 光山 晋一, 鈴木 研裕, 岩渕 敏久, 住吉 辰朗, 井上 弘, 柵瀬 信太郎, 小野寺 久, 日本消化器外科学会雑誌, 40, 7, 1099, 1099, 2007年07月
(一社)日本消化器外科学会, 日本語

ダブルバルーン式小腸内視鏡によって診断され外科的切除に至った小腸脂肪腫の1例
武田 崇志, 大東 誠司, 氏家 秀樹, 光山 晋一, 鈴木 研祐, 岩渕 敏久, 住吉 辰朗, 井上 弘, 柵瀬 信太郎, 小野寺 久, 日本消化器外科学会雑誌, 40, 7, 1116, 1116, 2007年07月
(一社)日本消化器外科学会, 日本語

GISTの治療戦略 GISTに併存した悪性腫瘍の解析　　　　　　　　　　　　　　　
氏家 秀樹, 大東 誠司, 武田 崇志, 光山 晋一, 鈴木 研裕, 岩渕 敏久, 住吉 辰朗, 井上 弘, 柵瀬 信太郎, 西尾 剛毅, 小野寺 久, 日本外科系連合学会誌, 32, 3, 530, 530, 2007年06月
日本外科系連合学会, 日本語

【腫瘍外科治療の最前線】大腸・肛門の腫瘍性疾患 稀な組織型の大腸腫瘍 非上皮性腫瘍
小野寺 久, 光山 晋一, 氏家 秀樹, 武田 崇志, 鈴木 研裕, 西尾 梨沙, 濱中 洋平, 岩渕 敏久, 住吉 辰朗, 井上 弘, 大東 誠司, 柵瀬 信太郎, 外科治療, 96, 増刊, 539, 544, 2007年04月
大腸の非上皮性腫瘍は間質成分由来の腫瘍であり、良性と悪性がある。良性腫瘍としては平滑筋腫、脂肪腫、神経線維腫、血管腫およびリンパ管腫があげられ、悪性腫瘍としてはGIST、悪性リンパ腫、悪性黒色腫が代表的である。臨床的に重要な疾患は悪性腫瘍であるが、発生頻度は大腸癌の約1/80である。GISTや悪性黒色腫は直腸に多く、悪性リンパ腫は直腸に加えて盲腸部に多い。上皮性腫瘍に比べて大きさの割に腸管の進展性が保たれているため狭窄をきたすことは少なく、腹部腫瘤や健診で偶然発見されることが多い。GISTは外科手術と分子標的療法、悪性リンパ腫と悪性黒色腫は外科手術と化学療法が標準治療である。(著者抄録), (株)永井書店, 日本語

【腫瘍外科治療の最前線】大腸・肛門の腫瘍性疾患 稀な組織型の大腸腫瘍 非上皮性腫瘍
小野寺 久, 光山 晋一, 氏家 秀樹, 武田 崇志, 鈴木 研裕, 西尾 梨沙, 濱中 洋平, 岩渕 敏久, 住吉 辰朗, 井上 弘, 大東 誠司, 柵瀬 信太郎, 外科治療, 96, 増刊, 539, 544, 2007年04月
大腸の非上皮性腫瘍は間質成分由来の腫瘍であり、良性と悪性がある。良性腫瘍としては平滑筋腫、脂肪腫、神経線維腫、血管腫およびリンパ管腫があげられ、悪性腫瘍としてはGIST、悪性リンパ腫、悪性黒色腫が代表的である。臨床的に重要な疾患は悪性腫瘍であるが、発生頻度は大腸癌の約1/80である。GISTや悪性黒色腫は直腸に多く、悪性リンパ腫は直腸に加えて盲腸部に多い。上皮性腫瘍に比べて大きさの割に腸管の進展性が保たれているため狭窄をきたすことは少なく、腹部腫瘤や健診で偶然発見されることが多い。GISTは外科手術と分子標的療法、悪性リンパ腫と悪性黒色腫は外科手術と化学療法が標準治療である。(著者抄録), (株)永井書店, 日本語

IVRにて止血できた消化管および腹腔内出血の3例
氏家秀樹, 大東誠司, 武田崇史, 光山晋一, 鈴木研裕, 岩淵敏久, 住吉辰朗, 嶋田元, 井上弘, 柵瀬信太郎, 西尾剛毅, 小野寺久, 不破相勲, 齋田幸久, 堀木紀行, 藤田善幸, 日本腹部救急医学会雑誌, 27, 2, 369, 369, 2007年
(一社)日本腹部救急医学会, 日本語

術前にイマチニブを投与し括約筋温存を試みた直腸巨大GISTの1例
武田崇志, 岩渕敏久, 氏家秀樹, 光山晋一, 鈴木研裕, 濱中洋平, 西尾梨沙, 住吉辰朗, 井上弘, 大東誠司, 柵瀬信太郎, 小野寺久, 日本臨床外科学会雑誌, 68, 2, 520, 520, 2007年
日本臨床外科学会, 日本語

腫瘍外科治療の最前線 D.大腸・肛門の腫瘍性疾患 41.稀な組織型の大腸腫瘍-非上皮性腫瘍-
小野寺久, 光山晋一, 氏家秀樹, 武田崇志, 鈴木研裕, 西尾梨沙, 濱中洋平, 岩渕敏久, 住吉辰朗, 井上弘, 大東誠司, 柵瀬信太郎, 外科治療, 96, -, 539, 544, 2007年
大阪 : 永井書店, 日本語

セプラフィルム使用後に汎発性腹膜炎を呈した1例
星野好則, 大東誠司, 住吉辰朗, 光山晋一, 氏家秀樹, 武田崇志, 鈴木研裕, 濱中洋平, 西尾梨沙, 岩渕敏久, 井上弘, 柵瀬信太郎, 小野寺久, 日本臨床外科学会雑誌, 68, 4, 1048, 1048, 2007年
日本臨床外科学会, 日本語

GISTに併存した悪性腫瘍の解析
氏家秀樹, 大東誠司, 武田崇志, 光山晋一, 鈴木研裕, 岩渕敏久, 住吉辰朗, 井上弘, 柵瀬信太郎, 西尾剛毅, 小野寺久, 日本外科系連合学会誌, 32, 3, 530, 2007年
日本語

消化管gastrointestinal stromal tumor再発・進行症例に対するイマチニブの治療経験
氏家秀樹, 大東誠司, 武田崇志, 光山晋一, 鈴木研裕, 岩渕敏久, 住吉辰朗, 井上弘, 柵瀬信太郎, 小野寺久, 日本消化器外科学会雑誌, 40, 7, 1099, 1099, 2007年
(一社)日本消化器外科学会, 日本語

ダブルバルーン式小腸内視鏡によって診断され外科的切除に至った小腸脂肪腫の1例
武田崇志, 大東誠司, 氏家秀樹, 光山晋一, 鈴木研祐, 岩渕敏久, 住吉辰朗, 井上弘, 柵瀬信太郎, 小野寺久, 日本消化器外科学会雑誌, 40, 7, 1116, 1116, 2007年
(一社)日本消化器外科学会, 日本語

泌尿器科疾患との鑑別が必要であった傍大動脈リンパ節腫大の2例
光山晋一, 井上弘, 武田崇志, 氏家秀樹, 鈴木研裕, 岩渕敏久, 住吉辰朗, 大東誠司, 柵瀬信太郎, 小野寺久, 日本臨床外科学会雑誌, 68, 7, 1888, 1888, 2007年
日本臨床外科学会, 日本語

非定型抗酸菌症を合併した肺癌症例
尾辻瑞人, 大多和正樹, 氏家秀樹, 齋田幸久, 松迫正樹, 負門克典, 蝶名林直彦, 西村直樹, 鈴木高祐, 肺癌, 47, 5, 644, 644, 2007年
(NPO)日本肺癌学会, 日本語

腹腔内出血にて発症した胃動静脈奇形の一例
法地聡果, 岩渕敏久, 氏家秀樹, 住吉辰朗, 井上弘, 大東誠司, 柵瀬信太郎, 小野寺久, 日本臨床外科学会雑誌, 68, 10, 2686, 2686, 2007年
日本臨床外科学会, 日本語

ストーマ閉鎖術における巾着縫合を用いた皮膚縫合法の工夫
武田崇志, 大東誠司, 法地聡果, 氏家秀樹, 光山晋一, 鈴木研裕, 岡村淳, 岩渕敏久, 住吉辰朗, 嶋田元, 井上弘, 柵瀬信太郎, 小野寺久, 日本臨床外科学会雑誌, 68, 増刊, 1155, 1155, 2007年
日本臨床外科学会, 日本語

チーム医療で推進するFOLFIRI化学療法の有害事象対策
井上弘, 法地聡果, 光山晋一, 氏家秀樹, 武田崇志, 鈴木研裕, 岡村淳, 岩渕敏久, 住吉辰朗, 嶋田元, 大東誠司, 柵瀬信太郎, 小野寺久, 日本臨床外科学会雑誌, 68, 増刊, 532, 532, 2007年
日本臨床外科学会, 日本語

魚骨による小腸穿孔が疑われたCrohn病の1例
氏家秀樹, 柵瀬信太郎, 法地聡果, 武田崇志, 光山晋一, 鈴木研裕, 岡村淳, 岩渕敏久, 住吉辰朗, 嶋田元, 井上弘, 大東誠司, 西尾剛毅, 小野寺久, 日本臨床外科学会雑誌, 68, 増刊, 844, 844, 2007年
日本臨床外科学会, 日本語

成人Bochdalek孔ヘルニアの1例
光山晋一, 柵瀬信太郎, 法地聡果, 氏家秀樹, 武田崇志, 鈴木研裕, 岡村淳, 岩渕敏久, 住吉辰朗, 嶋田元, 井上弘, 大東誠司, 西尾剛毅, 小野寺久, 日本臨床外科学会雑誌, 68, 増刊, 702, 702, 2007年
日本臨床外科学会, 日本語

前立腺全摘出術後高率に発症する鼠径ヘルニアに適切な術式とは?
鈴木研裕, 柵瀬信太郎, 嶋田元, 光山晋一, 氏家秀樹, 武田崇志, 岩渕敏久, 住吉辰朗, 井上弘, 大東誠司, 西尾剛毅, 村石修, 小野寺久, 日本臨床外科学会雑誌, 68, 増刊, 571, 571, 2007年
日本臨床外科学会, 日本語

類基底細胞癌,Barrett食道腺癌,扁平上皮癌の同時性食道3多発癌の1例
法地聡果, 柵瀬信太郎, 鈴木研裕, 氏家秀樹, 武田崇志, 光山晋一, 岡村淳, 岩渕敏久, 住吉辰朗, 嶋田元, 井上弘, 大東誠司, 小野寺久, 日本臨床外科学会雑誌, 68, 11, 2911, 2911, 2007年
日本臨床外科学会, 日本語

消化管間質腫瘍(GIST)34例の臨床病理学的検討
濱中洋平, 氏家秀樹, 武田崇志, 光山晋一, 鈴木研裕, 西尾梨沙, 住吉辰朗, 岩渕敏久, 嶋田元, 井上弘, 大東誠司, 柵瀬信太郎, 小野寺久, 日本臨床外科学会雑誌, 67, 増刊, 784, 784, 2006年
日本臨床外科学会, 日本語

Molecular targeted therapy of lung cancer　　　　　　　　　　　　　　　
Hideki Ujiiie
Springer, 2017年, ［分担執筆］

胸部悪性疾患に対するCD44-IR700結合体を用いた近赤外光線免疫療法の確立
科学研究費助成事業 若手研究
2021年04月01日 - 2024年03月31日
氏家 秀樹
本研究の目的は，肺癌、悪性胸膜中皮腫などの胸部悪性腫瘍に対し、癌幹細胞のC D44をターゲットとした、「CD44抗体-IR700結合体」による光免疫治療（NIR-PIT）を確立することである。研究期間内に、「CD44抗体-IR700結合体」を利用したNIR-PITを確立し， NIR-PITスコープを開発する。また、In vitro, In vivoレベルで治療効果を検証し、「アブスコパル効果」を肺癌同所性モデルで検証し、ヒトへの臨床応用を目指す。初年度の目標として、
①「IR700」特異的なNIR-PITスコープの開発: 細径ファイバースコープを、IR700のレーザー波長で使用できるように調整し、ストレートタイプのレーザーファイバーでより広い範囲にレーザー照射可能なNIR-PITスコープを開発する。
②細胞株を用いた「CD44抗体-IR700」のがん細胞への集積確認と治療効果の評価（In vitro）: マウスがん細胞株 (マウスCD44(+)肺癌：LL/2 cellマウス/ヒト CD44抗体：IM7マウスCD44(+)中皮腫：AB22) を用い，CD44発現をwestern blotで確認し，CD44陽性株と陰性株を同定する。In Vitro実験では陽性株に「CD44抗体-IR700」を導入後，FACS/蛍光顕微鏡を用い細胞への集積性を確認する。レーザー照射を行い，MTS assayにより壊死細胞の評価を行い、治療効果判定を行うことを目標とした。
日本学術振興会, 若手研究, 北海道大学, 21K16507