The prognosis of endometrial cancers stratified with conventional risk factors and modified molecular classification
Hiroyuki Yamazaki, Hiroshi Asano, Kanako C. Hatanaka, Ryosuke Matsuoka, Yosuke Konno, Yoshihiro Matsuno, Yutaka Hatanaka, Hidemichi Watari
Cancer Science, 2022年09月
研究論文（学術雑誌）

Comparison between Urine and Cervical High-Risk HPV Tests for Japanese Women with ASC-US
Hiroyuki Yamazaki, Tsuneyuki Wada, Hiroshi Asano, Hiromasa Fujita, Kazuhira Okamoto, Hidemichi Watari
Diagnostics, 2021年10月14日
研究論文（学術雑誌）

The difficulty to diagnose cervical cancer developing in the perinatal period with the first‐trimester cytology: A retrospective study
Hiroyuki Yamazaki, Takashi Mitamura, Kei Ihira, Daisuke Endo, Manami Sakurai, Yosuke Konno, Hidemichi Watari
Journal of Obstetrics and Gynaecology Research, Wiley, 2021年06月09日
英語, 研究論文（学術雑誌）

Imaging-based definition of lower uterine segment carcinoma to improve the detection sensitivity of probable Lynch syndrome.
Hiroyuki Yamazaki
Japanese journal of clinical oncology, 2020年03月01日
研究論文（学術雑誌）, OBJECTIVE:The aim of this study was to investigate a magnetic resonance imaging-based definition of lower uterine segment carcinoma. METHODS:We retrospectively reviewed 587 consecutive patients with endometrial cancer who underwent hysterectomy. Lower uterine segment carcinoma was determined through pathological examination and magnetic resonance imaging assessment. For imaging assessment, the location of the inner lining of the uterus was classified into four equal parts on a sagittal section image. A tumor was defined as lower uterine segment carcinoma when its thickest part was located in the second or the third part from the uterine fundus. Lower uterine segment carcinoma was further divided into lower uterine segment in a narrow sense, upon which diagnosis was exclusively based on pathological findings, and lower uterine segment in a broad sense that were the remaining lower uterine segment carcinomas except lower uterine segment carcinomas in a narrow sense. The relationship between lower uterine segment carcinoma and probable Lynch syndrome was investigated. Patients with loss of MSH2, MSH6, and PMS2 expression or those with tumors with loss of MLH1 and absence of MLH1 promoter methylation were diagnosed as probable Lynch syndrome. RESULTS:Lower uterine segment carcinoma was identified in 59 (10.2%) patients. Twenty-eight (47.5%) patients were categorized as lower uterine segment in a narrow sense and 31 (52.5%) as lower uterine segment in a broad sense. Among them, probable Lynch syndrome was identified in 12 (20.3%) cases. There was no difference in clinical profiles, including the prevalence of probable Lynch syndrome between the two categories. CONCLUSIONS:A magnetic resonance imaging-based expanded definition of lower uterine segment carcinoma is likely to secure characteristics equivalent to a conventional pathology-based definition of lower uterine segment carcinoma. The novel definition of lower uterine segment carcinoma might improve the detection of probable Lynch syndrome.

Therapeutic significance of full lymphadenectomy in early-stage ovarian clear cell carcinoma
Hiroyuki Yamazaki, Yukiharu Todo, Chisa Shimada, Sho Takeshita, Shinichiro Minobe, Kazuhira Okamoto, Katsushige Yamashiro, Hidenori Kato
Journal of Gynecologic Oncology, 29, 2, Asian Society of Gynecologic Oncology$\mathsemicolon$ Korean Society of Gynecologic Oncology and Colposcopy ({KAMJE}), 2018年
研究論文（学術雑誌）

A prediction model of survival for patients with bone metastasis from uterine cervical cancer
Hiroko Matsumiya, Yukiharu Todo, Kazuhira Okamoto, Sho Takeshita, Hiroyuki Yamazaki, Katsushige Yamashiro, Hidenori Kato
Journal of Gynecologic Oncology, 27, 6, Asian Society of Gynecologic Oncology$\mathsemicolon$ Korean Society of Gynecologic Oncology and Colposcopy ({KAMJE}), 2016年
研究論文（学術雑誌）

Relationship between removal of circumflex iliac nodes distal to the external iliac nodes and postoperative lower-extremity lymphedema in uterine cervical cancer.
Hiroyuki Yamazaki
Gynecologic oncology, 2015年09月10日
研究論文（学術雑誌）,

Objective

This study aimed to determine if there is a causal relationship between removal of the circumflex iliac nodes distal to the external iliac nodes (CINDEIN) and postoperative lower-extremity lymphedema (POLEL) after systematic lymphadenectomy in patients with cervical cancer.

Methods

A retrospective chart review was performed for all living cervical cancer patients who underwent lymphadenectomy and were managed at Hokkaido Cancer Center between 1993 and 2013. The type of lymphadenectomy gradually shifted from lymphadenectomy with removal of CINDEIN to without CINDEIN dissection during this period. The study period was divided into two phases: from 1993-2007 (first phase) and from 2008-2013 (second phase). We identified patients with POLEL. Logistic regression analysis was used to select the risk factors for POLEL.

Results

Implementation of CINDEIN-dissection lymphadenectomy (94.0% vs. 20.6%, p<0.0001) and adjuvant radiotherapy (26.1% vs. 4.5%, p<0.0001) was significantly higher in the first phase than in the second phase. Of 398 patients evaluated, POLEL was noted in medical records of 80 (20.1%) patients with a median follow-up period of 78.0months. The occurrence rate of POLEL was significantly higher in the first phase than in the second phase (32.2% vs. 8.0%, p<0.0001), despite no change in the number of dissected lymph nodes between the two phases. Multivariate analysis showed that adjuvant radiation therapy (odds ratio=2.6, 95% confidence interval=1.4-4.8) and removal of CINDEIN (odds ratio=4.6, 95% confidence interval=2.4-9.0) were independent risk factors for POLEL.

Conclusion

Elimination of CINDEIN dissection is helpful for reducing the incidence of POLEL.

Pretreatment risk factors for parametrial involvement in FIGO stage IB1 cervical cancer.
Hiroyuki Yamazaki
Journal of gynecologic oncology, 2015年07月14日
研究論文（学術雑誌）,

Objective

All patients with stage IB1 cervical cancer do not need to undergo parametrectomy. Some low-risk criteria for parametrial involvement (PI) have been proposed based on pathological findings. The aim of this study was to determine pretreatment risk factors for PI in stage IB1 cervical cancer.

Methods

We retrospectively reviewed 115 patients with stage IB1 cervical cancer who underwent radical hysterectomy or radical trachelectomy. Magnetic resonance imaging (MRI) was performed and serum concentrations of squamous cell carcinoma antigen (SCC-Ag) and cancer antigen 125 (CA-125) were determined in all patients before initial treatment. The following pretreatment factors were investigated: histological variant, maximum tumor diameter, tumor volume (volume index), pelvic lymph node enlargement, and serum tumor markers. Logistic regression analysis was used to select the independent risk factors for PI.

Results

Eighteen of the 115 patients (15.7%) were pathologically diagnosed with PI. Multivariate analysis confirmed the following independent risk factors for PI: MRI-based tumor diameter ≥ 25 mm (odds ratio [OR], 9.9; 95% confidence interval [CI], 2.1 to 48.1), MRI-based volume index ≥ 5,000 mm³ (OR, 13.3; 95% CI, 1.4 to 125.0), and positive serum tumor markers SCC-Ag ≥ 1.5 ng/mL or CA-125 ≥ 35 U/mL (OR, 5.7; 95% CI, 1.3 to 25.1). Of 53 patients with no risk factors for PI, none had PI.

Conclusion

Less radical surgery may become one of the treatment options for stage IB1 cervical cancer patients with MRI-based tumor diameter <25 mm, MRI-based volume index <5,000 mm³, and negativity for SCC-Ag and CA-125.

腟式細切により子宮を回収した電動モルセレーターを使用しないTLH後に発生した異所性子宮筋腫の1例
石塚 泰也, 工藤 正尊, 大原 康弘, 山崎 博之, 井平 圭, 宇田 智浩, 中谷 真紀子, 加藤 達矢, 渡利 英道, 櫻木 範明, 日本産科婦人科内視鏡学会雑誌, 33, 1, 131, 137, 2017年04月
46歳(1経妊1経産)。子宮平滑筋腫に対する電動セルモーターを使用しない腹腔鏡下子宮全摘出術後59ヵ月目の定期検診にて腟断端右端の腫瘤影を指摘された。各種検査結果と手術歴から異所性子宮筋腫(PM)を第一に疑い、審査腹腔鏡となった。腹腔鏡所見では腟断端右端に相当する部位に後腹膜腔内に発育する6cm大の腫瘤性病変を認めたが、腸管との連続性はなかった。また、腟断端左側に同様の腫瘤が2個認められた。1個の腫瘤を摘出し、病理組織学的にPMと診断されたため、後日、腹腔鏡下に残りの腫瘤を摘出した。最終手術から1年経過現在、再発はみられていない。, (一社)日本産科婦人科内視鏡学会, 日本語

子宮頸癌に対する広汎子宮全摘術後の補助化学療法の有用性についての後方視的検討　　　　　　　　　　　　　　　
嶋田 知紗, 加藤 達矢, 朝野 拓史, 山崎 博之, 井平 圭, 遠藤 大介, 福本 俊, 宇田 智浩, 中谷 真紀子, 古田 祐, 三田村 卓, 金野 陽輔, 武田 真人, 小林 範子, 工藤 正尊, 渡利 英道, 櫻木 範明, 日本婦人科腫瘍学会雑誌, 34, 3, 434, 434, 2016年06月
(公社)日本婦人科腫瘍学会, 日本語

検尿カップによる自己採尿検体を用いた子宮頸がん検診の実施可能性についての検討　　　　　　　　　　　　　　　
第75回日本産科婦人科学会学術講演会, 2023年05月13日, ポスター発表
2023年05月12日 - 2023年05月14日

子宮頸がんの予防　　　　　　　　　　　　　　　
北海道大学医学部医学科
2023年04月