Ishikawa Masayori
| Faculty of Health Sciences Health Sciences Biomedical Science and Engineering | Professor |
Last Updated :2025/06/07
■Researcher basic information
Profile Information
- Research Topics
1. Advanced medical engineering and physics in radiation medicine
2. Absorbed dose measurement in radiotherapy
3. Radiation measurement in radiology
4. Quality assurance and quality control (QA/QC) in radiotherapy
Researchmap personal page
Home Page URL
Researcher number
- 80314772
J-Global ID
Research Keyword
Research Field
Educational Organization
- Bachelor's degree program, Departments of Health Sciences, School of Medicine
- Master's degree program, Graduate School of Biomedical Science and Engineering
- Doctoral (PhD) degree program, Graduate School of Biomedical Science and Engineering
■Career
Career
- Apr. 2015 - Present
Hokkaido University, Graduate School of Health Sciences, Professor - May 2010 - Mar. 2015
Hokkaido University, Graduate School of Medicine, Professor - Apr. 2008 - Apr. 2010
Hokkaido University, Graduate School of Medicine, Research Associate - Apr. 2006 - Mar. 2008
Hokkaido University Hospital, Department of Medical Physics, Research Associate - Apr. 2005 - Mar. 2006
The University of Tokyo, Graduate School of Technology, Research Assistant - Apr. 2003 - Mar. 2005
The University of Tokyo, Research Center for Nuclear Science and Technology, Research Assistant - Jul. 1999 - Mar. 2003
Hiroshima University, Research Institute for Radiation Biology and Medicine, Research Assistant
Educational Background
■Research activity information
Awards
- Nov. 2019, Japanese Cancer Association, 9th JCA-CHAAO award
動体追跡技術と同期照射技術を用いた高精度放射線治療の開発と臨床研究
Hiroki Shirato;Shinichi Shimizu;Rikiya Onimaru;Naofumi Shinagawa;Daisuke Abo;Norio Katoh;Kikuo Umegaki;Masayori Ishikawa;Naoki Miyamoto;Hidefumi Aoyama - Apr. 2018, Japanese Society of Medical Physics, Oral Presentation Award
Fundamental study on dosimetric error due to phantom setup error for film-based dose distribution analysis
Masayori Ishikawa - Nov. 2017, Japanese Society for Radiation Oncology, Best Reviewer's Award
Masayori Ishikawa - Jul. 2017, Graduate School of Health Sciences, Hokkaido University, Best Paper Award
Masayori Ishikawa - Feb. 2016, Hokkaido University, Hokkaido University President Award for Research Activity
Masayori Ishikawa - Mar. 2015, Hokkaido University, Hokkaido University President Award for Research Activity
Masayori Ishikawa - Feb. 2015, Hokkaido Prefecture, Hokkaido Science and Technology Incentive Award
Masayori Ishikawa - Dec. 2014, Japanese Society for Radiation Oncology, Bewst Presentation Award
Masayori Ishikawa - Sep. 2014, 7th Korea-Japan Joint Meeting on Medical Physics, Oral Presentation Award
Masayori Ishikawa - Sep. 2014, 7th Korea-Japan Joint Meeting on Medical Physics, Poster Presentation Award
Masayori Ishikawa - Mar. 2013, Graduate School of Medicine and Faculty of Medicine, Hokkaido University, Best Research Award
Masayori Ishikawa - Apr. 2012, Japanese Society of Medical Physics, President Award
Masayori Ishikawa - Nov. 2011, Japanese Society for Radiation Oncology, Bewst Presentation Award
Masayori Ishikawa - Apr. 2008, Japanese Society of Medical Physics, President Award
Masayori Ishikawa - Apr. 2007, Japanese Society of Medical Physics, 11th Best Research Paper Award
Masayori Ishikawa - Nov. 2006, Japanese Society for Radiation Oncology, Bewst Presentation Award
Masayori Ishikawa
Papers
- Automatic assignment of optimal data acquisition protocols for MRI examinations in Japanese
Yusuke Fukui, Yukihiro Nagatani, Hidetoshi Matsui, Masayori Ishikawa, Shinnosuke Hiratsuka, Harumi Iguchi, Masahiro Yoshimura, Yoshiyuki Watanabe
Multimedia Tools and Applications, Springer Science and Business Media LLC, 01 Oct. 2024, [Peer-reviewed]
Scientific journal - Cell-cycle dependence on the biological effects of boron neutron capture therapy and its modification by polyvinyl alcohol
Yusuke Matsuya, Tatsuhiko Sato, Tamon Kusumoto, Yoshie Yachi, Ryosuke Seino, Misako Miwa, Masayori Ishikawa, Shigeo Matsuyama, Hisanori Fukunaga
Scientific Reports, 14, 1, Springer Science and Business Media LLC, 19 Jul. 2024, [Peer-reviewed]
Scientific journal, Abstract
Boron neutron capture therapy (BNCT) is a unique radiotherapy of selectively eradicating tumor cells using boron compounds (e.g., 4-borono-l-phenylalanine [BPA]) that are heterogeneously taken up at the cellular level. Such heterogenicity potentially reduces the curative efficiency. However, the effects of temporospatial heterogenicity on cell killing remain unclear. With the technical combination of radiation track detector and biophysical simulations, this study revealed the cell cycle-dependent heterogenicity of BPA uptake and subsequent biological effects of BNCT on HeLa cells expressing fluorescent ubiquitination-based cell cycle indicators, as well as the modification effects of polyvinyl alcohol (PVA). The results showed that the BPA concentration in the S/G2/M phase was higher than that in the G1/S phase and that PVA enhances the biological effects both by improving the uptake and by canceling the heterogenicity. These findings might contribute to a maximization of therapeutic efficacy when BNCT is combined with PVA and/or cell cycle-specific anticancer agents. - A novel method for measurements of sleep/wake states, feeding and drinking behaviors using the tracking technique of 3D positions in freely moving mice
Hamada T, Sutherland K, Ishikawa M, Saito J, Miyamoto N, Honma S, Shirato H, Honma K-I ( * Correspondence)
Biochemical and Biophysical Research Communications, Jul. 2024, [Peer-reviewed]
English, Scientific journal - CT number calibration audit in photon radiation therapy.
Minoru Nakao, Shuichi Ozawa, Hideharu Miura, Kiyoshi Yamada, Masahiro Hayata, Kosuke Hayashi, Daisuke Kawahara, Takeo Nakashima, Yusuke Ochi, Takuro Okumura, Haruhide Kunimoto, Atsushi Kawakubo, Hayate Kusaba, Hiroshige Nozaki, Kosaku Habara, Naoki Tohyama, Teiji Nishio, Mitsuhiro Nakamura, Toshiyuki Minemura, Hiroyuki Okamoto, Masayori Ishikawa, Masahiko Kurooka, Hidetoshi Shimizu, Kenji Hotta, Masahide Saito, Masahiro Nakano, Masato Tsuneda, Yasushi Nagata
Medical physics, 51, 3, 1571, 1582, Mar. 2024, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Inadequate computed tomography (CT) number calibration curves affect dose calculation accuracy. Although CT number calibration curves registered in treatment planning systems (TPSs) should be consistent with human tissues, it is unclear whether adequate CT number calibration is performed because CT number calibration curves have not been assessed for various types of CT number calibration phantoms and TPSs. PURPOSE: The purpose of this study was to investigate CT number calibration curves for mass density (ρ) and relative electron density (ρe ). METHODS: A CT number calibration audit phantom was sent to 24 Japanese photon therapy institutes from the evaluating institute and scanned using their individual clinical CT scan protocols. The CT images of the audit phantom and institute-specific CT number calibration curves were submitted to the evaluating institute for analyzing the calibration curves registered in the TPSs at the participating institutes. The institute-specific CT number calibration curves were created using commercial phantom (Gammex, Gammex Inc., Middleton, WI, USA) or CIRS phantom (Computerized Imaging Reference Systems, Inc., Norfolk, VA, USA)). At the evaluating institute, theoretical CT number calibration curves were created using a stoichiometric CT number calibration method based on the CT image, and the institute-specific CT number calibration curves were compared with the theoretical calibration curve. Differences in ρ and ρe over the multiple points on the curve (Δρm and Δρe,m , respectively) were calculated for each CT number, categorized for each phantom vendor and TPS, and evaluated for three tissue types: lung, soft tissues, and bones. In particular, the CT-ρ calibration curves for Tomotherapy TPSs (ACCURAY, Sunnyvale, CA, USA) were categorized separately from the Gammex CT-ρ calibration curves because the available tissue-equivalent materials (TEMs) were limited by the manufacturer recommendations. In addition, the differences in ρ and ρe for the specific TEMs (ΔρTEM and Δρe,TEM , respectively) were calculated by subtracting the ρ or ρe of the TEMs from the theoretical CT-ρ or CT-ρe calibration curve. RESULTS: The mean ± standard deviation (SD) of Δρm and Δρe,m for the Gammex phantom were -1.1 ± 1.2 g/cm3 and -0.2 ± 1.1, -0.3 ± 0.9 g/cm3 and 0.8 ± 1.3, and -0.9 ± 1.3 g/cm3 and 1.0 ± 1.5 for lung, soft tissues, and bones, respectively. The mean ± SD of Δρm and Δρe,m for the CIRS phantom were 0.3 ± 0.8 g/cm3 and 0.9 ± 0.9, 0.6 ± 0.6 g/cm3 and 1.4 ± 0.8, and 0.2 ± 0.5 g/cm3 and 1.6 ± 0.5 for lung, soft tissues, and bones, respectively. The mean ± SD of Δρm for Tomotherapy TPSs was 2.1 ± 1.4 g/cm3 for soft tissues, which is larger than those for other TPSs. The mean ± SD of Δρe,TEM for the Gammex brain phantom (BRN-SR2) was -1.8 ± 0.4, implying that the tissue equivalency of the BRN-SR2 plug was slightly inferior to that of other plugs. CONCLUSIONS: Latent deviations between human tissues and TEMs were found by comparing the CT number calibration curves of the various institutes. - Technical note: Point-by-point ion-recombination correction for accurate dose profile measurement in high dose-per-pulse irradiation field.
Hideki Kojima, Masayori Ishikawa, Makoto Takigami
Medical physics, 50, 11, 7281, 7293, Nov. 2023, [Corresponding author], [International Magazine]
English, Scientific journal, BACKGROUND: Although flattening filter free (FFF) beams are commonly used in clinical treatment, the accuracy of dose measurements in FFF beams has been questioned. Higher dose per pulse (DPP) such as FFF beams from a linear accelerator may cause problems in dose profile measurements using an ionization chamber due to the change of the charge collection efficiency. Ionization chambers are commonly used for percent depth dose (PDD) measurements. Changes of DPP due to chamber movement during PDD measurement can vary the ion collection efficiency of ionization chambers. In the case of FF beams, the DPP fluctuation is negligible, but in the case of the FFF beams, the DPP is 2.5 ∼ 4 times larger than that of the FF beam, and the change in ion collection efficiency is larger than that of the FF beam. PDD profile normalized by maximum dose depth, 10 cm depth for example, may therefore be affected by the ion collection efficiency. PURPOSE: In this study, we investigate the characteristics of the ion collection efficiency change depending on the DPP of each ionization chamber in the FFF beam. We furthermore propose a method to obtain the chamber- independent PDD by applying a DPP-dependent ion recombination correction. METHODS: Prior to investigating the relationship between DPP and charge collection efficiency, Jaffe-plots were generated with different DPP settings to investigate the linearity between the applied voltage and collected charge. The absolute dose measurement using eight ionization chambers under the irradiation settings of 0.148, 0.087, and 0.008 cGy/pulse were performed. Applied voltages for the Jaffe-plots were 100, 125, 150, 200, 250, and 300 V. The ion recombination correction factor Pion was calculated by the two-voltage analysis (TVA) method at the applied voltages of 300 and 100 V. The DPP dependency of the charge collection efficiency for each ionization chamber were evaluated from the DPP- Pion plot. PDD profiles for the 10 MV FFF beam were measured using Farmer type chambers (TN30013, FC65-P, and FC65-G) and mini-type chambers (TN31010, TN31021, CC13, CC04, and FC23-C). The PDD profiles were corrected with ion recombination correction at negative and positive polar applied voltages of 100 and 300 V. RESULTS: From the DPP-Pion relation for each ionization chamber with DPP ranging from 0.008 cGy/pulse to 0.148 cGy/pulse, all Farmer and mini-type chambers satisfied the requirements described in AAPM TG-51 addendum. However, Pion for the CC13 was most affected by DPP among tested chambers. The maximum deviation among PDDs using eight ionization chambers for 10 MV FFF was about 1%, but the deviation was suppressed to about 0.5% by applying ion recombination correction at each depth. CONCLUSIONS: In this study, the deviation of PDD profile among the ionization chambers was reduced by the ion recombination coefficient including the DPP dependency, especially for high DPP beams such as FFF beams. The present method is particularly effective for CC13, where the ion collection efficiency is highly DPP dependent. - A virtual audit system for intensity-modulated radiation therapy credentialing in Japan Clinical Oncology Group clinical trials: A pilot study.
Mitsuhiro Nakamura, Dejun Zhou, Toshiyuki Minemura, Satoshi Kito, Hiroyuki Okamoto, Naoki Tohyama, Masahiko Kurooka, Yu Kumazaki, Masayori Ishikawa, Catharine H Clark, Elizabeth Miles, Joerg Lehmann, Nicolaus Andratschke, Stephen Kry, Satoshi Ishikura, Takashi Mizowaki, Teiji Nishio
Journal of applied clinical medical physics, 24, 6, e14040, Jun. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: The Medical Physics Working Group of the Radiation Therapy Study Group at the Japan Clinical Oncology Group is currently developing a virtual audit system for intensity-modulated radiation therapy dosimetry credentialing. The target dosimeters include films and array detectors, such as ArcCHECK (Sun Nuclear Corporation, Melbourne, Florida, USA) and Delta4 (ScandiDos, Uppsala, Sweden). This pilot study investigated the feasibility of our virtual audit system using previously acquired data. METHODS: We analyzed 46 films (32 and 14 in the axial and coronal planes, respectively) from 29 institutions. Global gamma analysis between measured and planned dose distributions used the following settings: 3%/3 mm criteria (the dose denominator was 2 Gy), 30% threshold dose, no scaling of the datasets, and 90% tolerance level. In addition, 21 datasets from nine institutions were obtained for array evaluation. Five institutions used ArcCHECK, while the others used Delta4. Global gamma analysis was performed with 3%/2 mm criteria (the dose denominator was the maximum calculated dose), 10% threshold dose, and 95% tolerance level. The film calibration and gamma analysis were conducted with in-house software developed using Python (version 3.9.2). RESULTS: The means ± standard deviations of the gamma passing rates were 99.4 ± 1.5% (range, 92.8%-100%) and 99.2 ± 1.0% (range, 97.0%-100%) in the film and array evaluations, respectively. CONCLUSION: This pilot study demonstrated the feasibility of virtual audits. The proposed virtual audit system will contribute to more efficient, cheaper, and more rapid trial credentialing than on-site and postal audits; however, the limitations should be considered when operating our virtual audit system. - Plan quality association between dummy run and individual case review in a prospective multi-institutional clinical trial of postoperative cervical cancer patients treated with intensity-modulated radiotherapy: Japan clinical Oncology Group study (JCOG1402).
Hiroyuki Okamoto, Naoya Murakami, Fumiaki Isohashi, Takahiro Kasamatsu, Yoko Hasumi, Hiroaki Kobayashi, Masayori Ishikawa, Mitsuhiro Nakamura, Teiji Nishio, Hiroshi Igaki, Satoshi Ishikura, Nobuo Yaegashi, Takashi Mizowaki, Yasumasa Nishimura, Takafumi Toita
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 183, 109630, 109630, Jun. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND AND PURPOSE: The Japan Clinical Oncology Group (JCOG) 1402 conducted a multicenter clinical trial of postoperative intensity-modulated radiotherapy (IMRT) for high-risk uterine cervical cancer patients. We assess effectiveness of the quality assurance (QA) program in central review through dummy runs (DRs) performed before patient enrollment and post-treatment individual case review (ICR), and clarify the pitfalls in treatment planning. MATERIAL AND METHODS: The ICRs were conducted using the same QA program as the DR for 214 plans. The deviations were compared with those demonstrated in the DRs, and the pitfalls were clarified. Fifteen face-to-face meetings were held with physicians at participating institutions to provide feedback. RESULTS: Two-hundred and eighty-eight deviations and nine violations were detected in the 214 plans. The patterns of the deviations observed in the ICRs were similar to that in the DR. Frequent deviations were observed in clinical target volume (CTV) delineations, 50% in the DRs and 37% in the ICRs, respectively. In the ICRs, approximately 1.4 deviations/violations were observed per plan, which was lower than DR. Nine violations included inaccurate CTV delineation and improper PTV (planning target volume) margin, which had risks in loco-regional failures by inadequate dose coverage. CONCLUSIONS: Our developed QA program commonly used in DR and ICR clarified the pitfalls in treatment plans. Although the frequent deviations in CTV delineations were observed in the ICR, the deviations decreased compared to that in the DR. More specified face-to-face meetings with participating institutions will be necessary to maintain the quality of IMRT in the clinical protocol. - Improvement of Crystal Identification Accuracy for Depth-of-Interaction Detector System with Peak-to-Charge Discrimination Method.
Kento Miyata, Ryo Ogawara, Masayori Ishikawa
Sensors (Basel, Switzerland), 23, 10, 4584, 4584, 09 May 2023, [Corresponding author], [International Magazine]
English, Scientific journal, In positron emission tomography (PET), parallax errors degrade spatial resolution. The depth of interaction (DOI) information provides the position in the depth of the scintillator interacting with the γ-rays, thus reducing parallax errors. A previous study developed a Peak-to-Charge discrimination (PQD), which can separate spontaneous alpha decay in LaBr3:Ce. Since decay constant of GSO:Ce depends on Ce concentration, the PQD is expected to discriminate GSO:Ce scintillators with different Ce concentration. In this study, the PQD-based DOI detector system was developed, which can be processed online and implemented in PET. A detector was composed of four layers of GSO:Ce crystals and a PS-PMT. The four crystals were obtained from both the top and bottom of ingots with a nominal Ce concentration of 0.5 mol% and 1.5 mol%. The PQD was implemented on the Xilinx Zynq-7000 SoC board with 8ch Flash ADC to gain real-time processing, flexibility, and expandability. The results showed that the mean Figure of Merits in 1D between four scintillators are 1.5, 0.99, 0.91 for layers between 1st-2nd, 2nd-3rd, and 3rd-4th respectively, and the mean Error Rate in 1D between four scintillators are 3.50%, 2.96%, 13.3%, and 1.88% for layers 1, 2, 3, and 4, respectively. In addition, the introduction of the 2D PQDs resulted in the mean Figure of Merits in 2D greater than 0.9 and the mean Error Rate in 2D less than 3% in all layers. - Planning study: prone versus supine position for stereotactic body radiotherapy in prostate by CyberKnife.
Mitsuhiro Kon, Hiroyuki Okamoto, Satoshi Nakamura, Kotaro Iijima, Takahito Chiba, Mihiro Takemori, Hiroki Nakayama, Tetsu Nakaichi, Shohei Mikasa, Kyohei Fujii, Yuka Urago, Masayori Ishikawa, Toshimitsu Sofue, Shoichi Katsuta, Koji Inaba, Hiroshi Igaki, Tomohiko Aso
Journal of radiation research, 64, 1, 186, 194, 20 Jan. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, This study aimed to clarify the differences in radiotherapy dose characteristics and delivery efficiency between the supine and prone positions in patients with prostate cancer using the CyberKnife. The planning computed tomography (CT) and delineations of the prone position were obtained by rotating the supine CT images with delineations of 180° using image processing software. The optimization parameters for planning target volume (PTV) and organs at risk (OARs) were based on the prone position. The optimization parameters determined for the prone position were applied to the supine position for optimization and dose calculation. The dosimetric characteristics of the PTV and OARs, and delivery efficiency were compared between the two different patient positions. The plans in the prone position resulted in better PTV conformity index (nCI), rectum V90%, V80%, V75%, V50% and bladder V50%. A significant difference was observed in treatment time and depth along the central axis (dCAX) between the two plans. The mean treatment time per fraction and dCAX for the supine and prone positions were 20.9 ± 1.7 min versus 19.8 ± 1.3 min (P = 0.019) and 151.1 ± 33.6 mm versus 233.2 ± 8.8 mm (P < 0.001), respectively. In this study the prone position was found to improve dosimetric characteristics and delivery efficiency compared with the supine position during prostate cancer treatment with the CyberKnife. - Verification of patient-setup accuracy using a surface imaging system with steep measurement angle.
Fumihiro Sasaki, Yuusuke Yamashita, Satoshi Nakano, Masayori Ishikawa
Journal of applied clinical medical physics, 24, 4, e13872, 20 Dec. 2022, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, PURPOSE: We evaluate an SGRT device (Voxelan HEV-600 M/RMS) installed with Radixact, with the view angle of the Voxelan's camera at 74 degrees. The accuracy of Voxelan with this steep angle was evaluated with phantom experiments and inter-fractional setup errors of patients. METHODS: In the phantom experiments, the difference between the measured values of Voxelan from the truth was evaluated for translations and rotations. The inter-fractional setup error between the setup using skin markers with laser localizer (laser setup: LS) and the setup using Voxelan (surface setup: SS) was compared for head and neck (N = 19), chest (N = 7) and pelvis (N = 9) cases. The inter-fractional setup error was calculated by subtracting from bone matching by megavoltage computed tomography (MVCT) as ground truth. RESULTS: From the phantom experiments, the average difference between the measured values of Voxelan from the truth was within 1 mm and 1 degree. In all cases, inter-fractional setup error based on MVCT was not significantly different between LS and SS by Welch's t-test (P > 0.05). The vector offset of the LS for head and neck, chest, and pelvis were 6.5, 9.6, and 9.6 mm, respectively, and that of the SS were 5.8, 8.6, and 12.6 mm, respectively. Slight improvement was observed for the head and neck, and chest cases, however, pelvis cases were not improved because the umbilical region could not be clearly visualized as a reference. CONCLUSION: The results show that SS in Voxelan with an installation angle of 74 degrees is equal to or better than LS. - Improvement and benchmarking of the deterministic transport calculation code CBZ to design beam shaping assembly for BNCT.
Go Chiba, Hikaru Handa, Masayori Ishikawa
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 190, 110465, 110465, Dec. 2022, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, The quick and accurate neutron and photon transport calculations are desired in the optimization calculations for the neutron source design, and in the present work, we establish the deterministic neutron and photon transport calculation procedure with the nuclear reactor physics calculation code system CBZ. Numerical calculation conditions are carefully chosen, and the efficient and practical condition is determined. Test calculations are carried out for the simple cylindrical systems with various kinds of neutron moderators, and the results are compared with the reference solutions obtained by the continuous-energy Monte Carlo code PHITS. Generally good agreements are obtained for all the benchmark problems. In addition, another problem with the detailed geometry for the neutron source is prepared. In this realistic problem also, good agreement is obtained between CBZ and PHITS. These results demonstrate the high accuracy of CBZ in the application to the design optimization calculations for the neutron source. - A real-time measurement system for gene expression rhythms from deep tissues of freely moving mice under light-dark conditions.
Nakaya M, Wakamatsu M, Motegi H, Ami Tanaka A, Sutherland K, Ishikawa M, Ozaki M, Shirato H, Hamada K, Hamada T* (* Correspondence).
Biochemistry and Biophysics Reports, 32, 101344, 101344, Sep. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Clock gene expression in most organs of the living body exhibits a diurnal rhythm synchronized with the external 24 h light-dark (LD) cycle via circadian pacemaker suprachiasmatic nucleus (SCN). Disturbances in clock gene expression due to desynchronization of clock gene expression of the external LD cycle are risk factors for developing various diseases. Measuring the in vivo clock genes expression rhythm for a long duration under LD conditions can greatly contribute to understand the pathogenic mechanism of the disease caused by the disturbance of the biological rhythm. However, it is presently difficult to continuously measure gene expression for a long duration under LD conditions. In present study, we succeeded in measuring Period1 (Per1) gene expression under LD conditions using ultraviolet (UV) light with filter cut the visible light range. In addition, we succeeded in measuring the kinetic change of liver Per1 gene expression during the process of desynchronization of behavioral rhythm from the LD cycle by chronic administration of methamphetamine (MAP). In the future, by using this system to measure clock gene expression rhythms of brain tissues such as SCN and peripheral tissues under LD conditions, it could contribute to understand the onset mechanism of diseases induced by the desynchronization mechanism of biological rhythm to the LD cycle. - Inflammatory Signaling and DNA Damage Responses after Local Exposure to an Insoluble Radioactive Microparticle
Yusuke Matsuya, Nobuyuki Hamada, Yoshie Yachi, Yukihiko Satou, Masayori Ishikawa, Hiroyuki Date, Tatsuhiko Sato
Cancers, 14, 4, 1045, 1045, MDPI AG, 18 Feb. 2022, [Peer-reviewed]
Scientific journal, Cesium-bearing microparticles (Cs-BMPs) can reach the human respiratory system after inhalation, resulting in chronic local internal exposure. We previously investigated the spatial distribution of DNA damage induced in areas around a Cs-BMP; however, the biological impacts have not been fully clarified due to the limited amount of data. Here, we investigated the inflammatory signaling and DNA damage responses after local exposure to a Cs-BMP in vitro. We used two normal human lung cell lines, i.e., lung fibroblast cells (WI-38) and bronchial epithelial cells (HBEC3-KT). After 24 h exposure to a Cs-BMP, inflammation was evaluated by immunofluorescent staining for nuclear factor κB (NF-κB) p65 and cyclooxygenase 2 (COX-2). The number of DNA double-strand breaks (DSBs) was also detected by means of phospholylated histone H2AX (γ-H2AX) focus formation assay. Cs-BMP exposure significantly increased NF-κB p65 and COX-2 expressions, which were related to the number of γ-H2AX foci in the cell nuclei. Compared to the uniform (external) exposure to 137Cs γ-rays, NF-κB tended to be more activated in the cells proximal to the Cs-BMP, while both NF-κB p65 and COX-2 were significantly activated in the distal cells. Experiments with chemical inhibitors for NF-κB p65 and COX-2 suggested the involvement of such inflammatory responses both in the reduced radiosensitivity of the cells proximal to Cs-BMP and the enhanced radiosensitivity of the cells distal from Cs-BMP. The data show that local exposure to Cs-BMP leads to biological effects modified by the NF-κB pathway, suggesting that the radiation risk for Cs-BMP exposure can differ from that estimated based on conventional uniform exposure to normal tissues. - Features of accelerator-based neutron source for boron neutron capture therapy calculated by particle and heavy ion transport code system (PHITS)
Yusuke Matsuya, Tamon Kusumoto, Yoshie Yachi, Yuho Hirata, Misako Miwa, Masayori Ishikawa, Hiroyuki Date, Yosuke Iwamoto, Shigeo Matsuyama, Hisanori Fukunaga
AIP Advances, 12, 2, 025013, 025013, AIP Publishing, 01 Feb. 2022, [Peer-reviewed]
Scientific journal - Prediction of target position from multiple fiducial markers by partial least squares regression in real-time tumor-tracking radiation therapy.
Kanako Ukon, Yohei Arai, Seishin Takao, Taeko Matsuura, Masayori Ishikawa, Hiroki Shirato, Shinichi Shimizu, Kikuo Umegaki, Naoki Miyamoto
Journal of radiation research, 62, 5, 926, 933, 13 Sep. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, The purpose of this work is to show the usefulness of a prediction method of tumor location based on partial least squares regression (PLSR) using multiple fiducial markers. The trajectory data of respiratory motion of four internal fiducial markers inserted in lungs were used for the analysis. The position of one of the four markers was assumed to be the tumor position and was predicted by other three fiducial markers. Regression coefficients for prediction of the position of the tumor-assumed marker from the fiducial markers' positions is derived by PLSR. The tracking error and the gating error were evaluated assuming two possible variations. First, the variation of the position definition of the tumor and the markers on treatment planning computed tomograhy (CT) images. Second, the intra-fractional anatomical variation which leads the distance change between the tumor and markers during the course of treatment. For comparison, rigid predictions and ordinally multiple linear regression (MLR) predictions were also evaluated. The tracking and gating errors of PLSR prediction were smaller than those of other prediction methods. Ninety-fifth percentile of tracking/gating error in all trials were 3.7/4.1 mm, respectively in PLSR prediction for superior-inferior direction. The results suggested that PLSR prediction was robust to variations, and clinically applicable accuracy could be achievable for targeting tumors. - Fundamental study on quality assurance (QA) procedures for a real-time tumor tracking radiotherapy (RTRT) system from the viewpoint of imaging devices.
Suguru Kimura, Naoki Miyamoto, Kenneth L Sutherland, Ryusuke Suzuki, Hiroki Shirato, Masayori Ishikawa
Journal of applied clinical medical physics, 22, 7, 165, 176, Wiley, Jul. 2021, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, PURPOSE: The real-time tumor tracking radiotherapy (RTRT) system requires periodic quality assurance (QA) and quality control. The goal of this study is to propose QA procedures from the viewpoint of imaging devices in the RTRT system. METHODS: Tracking by the RTRT system (equips two sets of colored image intensifiers (colored I.I.s) fluoroscopy units) for the moving gold-marker (diameter 2.0 mm) in a rotating phantom were performed under various X-ray conditions. To analyze the relationship between fluoroscopic image quality and precision of gold marker coordinate calculation, the standard deviation of the 3D coordinate (σ3D [mm]) of the gold marker, the mean of the pattern recognition score (PRS) and the standard deviation of the distance between rays (DBR) (σDBR [mm]) were evaluated. RESULTS: When tracking with speed of 10-60 mm/s, σDBR increased, though the mean PRS did not change significantly (p>0.05). On the contrary, the mean PRS increased depending on the integral noise equivalent quanta (∫NEQ) that is an indicator of image quality calculated from the modulation transfer function (MTF) as an indicator of spatial resolution and the noise power spectrum (NPS) as an indicator of noise characteristic. CONCLUSION: The indicators of NEQ, MTF, and NPS were useful for managing the tracking accuracy of the RTRT system. We propose observing the change of these indicators as additional QA procedures for each imaging device from the commissioning baseline. - Period1 gene expression in the olfactory bulb and liver of freely moving streptozotocin-treated diabetic mouse.
Harumi Kanou, Kouki Nagasawa, Yuki Ishii, Aya Chishima, Juri Hayashi, Sanae Haga, Kenneth Sutherland, Masayori Ishikawa, Michitaka Ozaki, Hiroki Shirato, Kazuko Hamada, Toshiyuki Hamada
Biochemical and biophysical research communications, 560, 14, 20, 30 Jun. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, Clock genes express circadian rhythms in most organs. These rhythms are organized throughout the whole body, regulated by the suprachiasmatic nucleus (SCN) in the brain. Disturbance of these clock gene expression rhythms is a risk factor for diseases such as obesity. In the present study, to explore the role of clock genes in developing diabetes, we examined the effect of streptozotocin (STZ)-induced high glucose on Period1 (Per1) gene expression rhythm in the liver and the olfactory bub (OB) in the brain. We found a drastic increase of Per1 expression in both tissues after STZ injection while blood glucose content was low. After a rapid expression peak, Per1 expression showed no rhythm. Associated with an increase of glucose content, behavior became arrhythmic. Finally, we succeeded in detecting an increase of Per1 expression in mice hair follicles on day 1 after STZ administration, before the onset of symptoms. These results show that elevated Per1 expression by STZ plays an important role in the aggravation of diabetes. - A simulation-based study on water radiolysis species for H-1(+), He-4(2+), and C-12(6+) ion beams with multiple ionization using Geant4-DNA
Kentaro Baba, Tamon Kusumoto, Shogo Okada, Masayori Ishikawa
JOURNAL OF APPLIED PHYSICS, 129, 24, 244702, 244702, Jun. 2021, [Peer-reviewed], [Corresponding author]
English, Scientific journal - Report dose-to-medium in clinical trials where available; a consensus from the Global Harmonisation Group to maximize consistency.
Stephen F Kry, Jessica Lye, Catharine H Clark, Nicolaus Andratschke, Alexis Dimitriadis, David Followill, Rebecca Howell, Mohammad Hussein, Masayori Ishikawa, Satoshi Kito, Tomas Kron, Jonny Lee, Jeff Michalski, Angelo Filippo Monti, Nick Reynaert, Paige Taylor, Karen Venables, Ying Xiao, Joerg Lehmann
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 159, 106, 111, Jun. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: To promote consistency in clinical trials by recommending a uniform framework as it relates to radiation transport and dose calculation in water versus in medium. METHODS: The Global Quality Assurance of Radiation Therapy Clinical Trials Harmonisation Group (GHG; www.rtqaharmonization.org) compared the differences between dose to water in water (Dw,w), dose to water in medium (Dw,m), and dose to medium in medium (Dm,m). This was done based on a review of historical frameworks, existing literature and standards, clinical issues in the context of clinical trials, and the trajectory of radiation dose calculations. Based on these factors, recommendations were developed. RESULTS: No framework was found to be ideal or perfect given the history, complexity, and current status of radiation therapy. Nevertheless, based on the evidence available, the GHG established a recommendation preferring dose to medium in medium (Dm,m). CONCLUSIONS: Dose to medium in medium (Dm,m) is the preferred dose calculation and reporting framework. If an institution's planning system can only calculate dose to water in water (Dw,w), this is acceptable. - Oxygen enhancement ratios of cancer cells after exposure to intensity modulated x-ray fields: DNA damage and cell survival.
Yusuke Matsuya, Stephen J McMahon, Karl T Butterworth, Shingo Naijo, Isshi Nara, Yoshie Yachi, Ryo Saga, Masayori Ishikawa, Tatsuhiko Sato, Hiroyuki Date, Kevin M Prise
Physics in medicine and biology, 66, 7, 075014, 075014, {IOP} Publishing, 06 Apr. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, Hypoxic cancer cells within solid tumours show radio-resistance, leading to malignant progression in fractionated radiotherapy. When prescribing dose to tumours under heterogeneous oxygen pressure with intensity-modulated radiation fields, intercellular signalling could have an impact on radiosensitivity between in-field and out-of-field cells. However, the impact of hypoxia on radio-sensitivity under modulated radiation intensity remains to be fully clarified. Here, we investigate the impact of hypoxia on in-field and out-of-field radio-sensitivities using two types of cancer cells, DU145 and H1299. Using a nBIONIX hypoxic culture kit and a shielding technique to irradiate 50% of a cell culture flask, oxygen enhancement ratios (OERs) for double-strand breaks (DSB) and cell death endpoints were determined. These in vitro measurements indicate that hypoxia impacts out-of-field cells, although the hypoxic impacts on out-of-field cells for cell survival were dose-dependent and smaller compared to those for in-field and uniformly irradiated cells. These decreased radio-sensitivities of out-of-field cells were shown as a consistent tendency for both DSB and cell death endpoints, suggesting that radiation-induced intercellular communication is of importance in advanced radiotherapy dose-distributions such as with intensity-modulated radiotherapy. - Stability of d-luciferin for bioluminescence to detect gene expression in freely moving mice for long durations.
Kanako Nakajima, Kazuko Hamada, Ryoga Ito, Yukina Yoshida, Kenneth Sutherland, Masayori Ishikawa, Michitaka Ozaki, Hiroki Shirato, Toshiyuki Hamada
Luminescence : the journal of biological and chemical luminescence, 36, 1, 94, 98, Feb. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, Circadian disturbance of clock gene expression is a risk factor for diseases such as obesity, cancer, and sleep disorders. To study these diseases, it is necessary to monitor and analyze the expression rhythm of clock genes in the whole body for a long duration. The bioluminescent reporter enzyme firefly luciferase and its substrate d-luciferin have been used to generate optical signals from tissues in vivo with high sensitivity. However, little information is known about the stability of d-luciferin to detect gene expression in living animals for a long duration. In the present study, we examined the stability of a luciferin solution over 21 days. l-Luciferin, which is synthesized using racemization of d-luciferin, was at high concentrations after 21 days. In addition, we showed that bioluminescence of Period1 (Per1) expression in the liver was significantly decreased compared with the day 1 solution, although locomotor activity rhythm was not affected. These results showed that d-luciferin should be applied to the mouse within, at most, 7 days to detect bioluminescence of Per1 gene expression rhythm in vivo. - Quantitative estimation of track segment yields of water radiolysis species under heavy ions around Bragg peak energies using Geant4-DNA.
Kentaro Baba, Tamon Kusumoto, Shogo Okada, Ryo Ogawara, Satoshi Kodaira, Quentin Raffy, Rémi Barillon, Nicolas Ludwig, Catherine Galindo, Philippe Peaupardin, Masayori Ishikawa
Scientific reports, 11, 1, 1524, 1524, 15 Jan. 2021, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, We evaluate the track segment yield G' of typical water radiolysis products (eaq-, ·OH and H2O2) under heavy ions (He, C and Fe ions) using a Monte Carlo simulation code in the Geant4-DNA. Furthermore, we reproduce experimental results of ·OH of He and C ions around the Bragg peak energies (< 6 MeV/u). In the relatively high energy region (e.g., > 10 MeV/u), the simulation results using Geant4-DNA have agreed with experimental results. However, the G-values of water radiolysis species have not been properly evaluated around the Bragg peak energies, at which high ionizing density can be expected. Around the Bragg peak energy, dense continuous secondary products are generated, so that it is necessary to simulate the radical-radical reaction more accurately. To do so, we added the role of secondary products formed by irradiation. Consequently, our simulation results are in good agreement with experimental results and previous simulations not only in the high-energy region but also around the Bragg peak. Several future issues are also discussed regarding the roles of fragmentation and multi-ionization to realize more realistic simulations. - Mouse period1 gene expression recording from olfactory bulb under free moving conditions with a portable optic fibre device.
Ryoga Ito, Kazuko Hamada, Shigeru Kasahara, Yoshihiro Kikuchi, Kanako Nakajima, Kenneth Sutherland, Hiroki Shirato, Michitaka Ozaki, Masayori Ishikawa, Toshiyuki Hamada
Luminescence : the journal of biological and chemical luminescence, 35, 8, 1248, 1253, Dec. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, Because the disruption of circadian clock gene is a risk factor in many diseases such as obesity and cancer, it is important to monitor and analyzed the expression of the rhythm of the clock gene throughout the body over a long period of time. Although we previously reported on a new gene expression analysis system tracking a target position on the body surface of freely moving mice, the experimental apparatus required a large space. We have therefore developed an in vivo recording system using a portable photomultiplier tube (PMT) system attached to an optical fibre. Directly connecting the target area with the device, we could easily measure the photon counts in a very small space. However, little information is known about the characteristics of optical fibres when exposed to twisting/looping in association with a moving mouse and the effect of the surface of optical fibre. In the present study, we report on the characteristics of optical fibres to detect gene expression rhythm in freely moving mice. Using this portable optical device directly connected with a target area, we were able to measure the circadian rhythm of clock gene expression over a prolonged period in freely moving mice in a small space. - An overview of the medical-physics-related verification system for radiotherapy multicenter clinical trials by the Medical Physics Working Group in the Japan Clinical Oncology Group-Radiation Therapy Study Group.
Teiji Nishio, Mitsuhiro Nakamura, Hiroyuki Okamoto, Satoshi Kito, Toshiyuki Minemura, Shuichi Ozawa, Yu Kumazaki, Masayori Ishikawa, Naoki Tohyama, Masahiko Kurooka, Takeo Nakashima, Hidetoshi Shimizu, Ryusuke Suzuki, Satoshi Ishikura, Yasumasa Nishimura
Journal of radiation research, 61, 6, 999, 1008, 16 Nov. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, The Japan Clinical Oncology Group-Radiation Therapy Study Group (JCOG-RTSG) has initiated several multicenter clinical trials for high-precision radiotherapy, which are presently ongoing. When conducting multi-center clinical trials, a large difference in physical quantities, such as the absolute doses to the target and the organ at risk, as well as the irradiation localization accuracy, affects the treatment outcome. Therefore, the differences in the various physical quantities used in different institutions must be within an acceptable range for conducting multicenter clinical trials, and this must be verified with medical physics consideration. In 2011, Japan's first Medical Physics Working Group (MPWG) in the JCOG-RTSG was established to perform this medical-physics-related verification for multicenter clinical trials. We have developed an auditing method to verify the accuracy of the absolute dose and the irradiation localization. Subsequently, we credentialed the participating institutions in the JCOG multicenter clinical trials that were using stereotactic body radiotherapy (SBRT) for lungs, intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) for several disease sites, and proton beam therapy (PT) for the liver. From the verification results, accuracies of the absolute dose and the irradiation localization among the participating institutions of the multicenter clinical trial were assured, and the JCOG clinical trials could be initiated. - Double recording system of Period1 gene expression rhythm in the olfactory bulb and liver in freely moving mouse.
Kazuko Hamada, Akari Oota, Ryoga Ito, Shigeru Kasahara, Kanako Nakajima, Yoshihiro Kikuchi, Kenneth Sutherland, Masayori Ishikawa, Hiroki Shirato, Michitaka Ozaki, Toshiyuki Hamada
Biochemical and biophysical research communications, 529, 4, 898, 903, 03 Sep. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, Clock genes express circadian rhythms in most organs. These rhythms are organized throughout the whole body, regulated by the suprachiasmatic nucleus (SCN) in the brain. Disturbance of these clock gene expression rhythms is a risk factor for diseases such as obesity and cancer. To understand the mechanism of regulating clock gene expression rhythms in vivo, multiple real time recording systems are required. In the present study, we developed a double recording system of Period1 expression rhythm in peripheral tissue (liver) and the brain. In peripheral tissue, quantification of gene expression in a steadily moving target was achieved by using a photomultiplier tube (PMT) attached to a tissue contact optical sensor (TCS). Using this technique, we were able to analyze circadian rhythms of clock gene expression over a prolonged period in the liver and olfactory bub (OB) of the brain. The present double recording system has no effect on behavioral activity or rhythm. Our novel system thus successfully quantifies clock gene expression in deep areas of the body in freely moving mice for a period sufficient to analyze circadian dynamics. In addition, our double recording system can be widely applied to many areas of biomedical research, as well as applications beyond medicine. - X線透視下手技における水晶体のリアルタイム被ばく計測の試み ファントム実験での検証
作原 祐介, 高田 剛志, 古徳 純一, 石川 正純, 近藤 浩史
日本インターベンショナルラジオロジー学会雑誌, 35, Suppl., 169, 169, (一社)日本インターベンショナルラジオロジー学会, Aug. 2020, [Peer-reviewed]
Japanese - Verification of dose estimation of Auger electrons emitted from Cu-64 using a combination of FNTD measurements and Monte Carlo simulations
Tamon Kusumoto, Yusuke Matsuya, Kentaro Baba, Ryo Ogawara, Mark S. Akselrod, Jonathan Harrison, Vasiliy Fomenko, Takeshi Kai, Masayori Ishikawa, Sumitaka Hasegawa, Satoshi Kodaira
Radiation Measurements, 132, Mar. 2020, [Peer-reviewed]
Scientific journal - Feasibility study on a novel tiny dosimeter using a barium titanate capacitor.
Yuma Kuga, Ryo Ogawara, Masayori Ishikawa
Journal of radiation research, 61, 1, 34, 43, 23 Jan. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, In our laboratory we have confirmed that the capacitance of barium titanate-based capacitors changes due to radiation. Since a commercially available capacitor is very small and inexpensive, it may be used as a multidimensional dose meter in which a large number of capacitor elements are arranged, or may be embedded in the body and used as an in-vivo dose meter. In this study we examined the usefulness of a dosimeter using the capacitance change of a barium titanate capacitor. As a basic property, it was confirmed that the dose linearity was good. With regard to dose rate characteristics and response to fractionated irradiation, capacitance change due to aging affects measurement accuracy, but online measurement of capacitance change immediately before irradiation can be performed to correct aging effects during irradiation. By doing this, we confirmed that the dose rate characteristics and the response to fractionated radiation are improved. - Dose reduction and image quality improvement of chest radiography by using bone-suppression technique and low tube voltage: a phantom study.
Satoshi Takagi, Tatsuya Yaegashi, Masayori Ishikawa
European radiology, 30, 1, 571, 580, Jan. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: To clarify the relationship between entrance surface dose (ESD) and physical image quality of original and bone-suppressed chest radiographs acquired using high and low tube voltages. METHODS: An anthropomorphic chest phantom and a 12-mm diameter spherical simulated nodule with a CT value of approximately + 100 HU were used. The lung field in the chest radiograph was divided into seven areas, and the nodule was set in a total of 66 positions. A total of 264 chest radiographs were acquired using four ESD conditions: approximately 0.3 mGy at 140 and 70 kVp and approximately 0.2 and 0.1 mGy at 70 kVp. The radiographs were processed to produce bone-suppressed images. Differences in contrast and contrast-to-noise ratio (CNR) values of the nodule between each condition and between the original and bone-suppressed images were analyzed by a two-sided Wilcoxon signed-rank test. RESULTS: In the areas not overlapping with the ribs, both contrast and CNR values were significantly increased with the bone-suppression technique (p < 0.01). In the bone-suppressed images, these values of the three conditions at 70 kVp were equal to or significantly higher than those of the condition at 140 kVp. There was no apparent decrease in these values between the ESD of approximately 0.3 and 0.1 mGy at 70 kVp. CONCLUSION: By using the shortest exposure time and the lowest tube voltage possible not to increase in blurring artifact and image noise, it is possible to improve the image quality of bone-suppressed images and reduce the patient dose. KEY POINTS: • The effectiveness of bone-suppression techniques differs in areas of lung field. • Image quality of bone-suppressed chest radiographs is improved by lower tube voltage. • Applying lower tube voltage to bone-suppressed chest radiographs leads to dose reduction. - [Real-time Lens Exposure Dose Measurement Using a Scintillator with Optical Fiber Dosimeter during Cardiac Catheter Operation].
Katsuhiko Hirota, Takuro Tanaka, Naoki Iwata, Masayori Ishikawa
Nihon Hoshasen Gijutsu Gakkai zasshi, 76, 8, 817, 827, 2020, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, In recent years, the exposure dose of the operator's eye lens during interventional radiology operations has become a problem. We therefore evaluated the feasibility of real-time lens dose measurement using scintillator with optical fiber (SOF) dosimeter. Given that the SOF dosimeter is calibrated for direct X-rays, we performed a calibration for scattered X-rays to investigate energy dependence and the accuracy of lens dose measurements. The detection limit was calculated using the Kaiser method. The SOF dosimeter and the radiophotoluminescence glass (RPLG) dosimeter were attached to the protective glasses worn by the operator, and the lens exposure dose of the operator during cardiac catheterization was measured. In the phantom experiment, the SOF dosimeter had an error rate of 5.45% based on the measured value of the ionization chamber dosimeter. The sensitivity characteristics of the SOF dosimeter were slightly reduced on the higher side of the effective energy. The difference in sensitivity was related to variations in the additional filter and energy dependency. The sensitivity difference was 18.5% at maximum. Furthermore, when the additional dose was displayed, the influence of noise on long-term measurement was considerable. Using the Kaiser method to obtain the detection limit, the accuracy of the integrated dose had SOF dosimeter error rates of 4.3% to 15.5% with respect to the integrated value of the RPLG dosimeter when calibrated by the ionization chamber dosimeter. The use of the SOF dosimeter allowed for the real-time visualization of the exposure status of the eye lens and measurements with a relatively high accuracy. - リアルタイム被ばく計測の試み ファントム実験での検証
作原 祐介, 中村 友亮, 清水 匡, 石川 正純, 高田 剛志, 古徳 純一, 近藤 浩史
日本インターベンショナルラジオロジー学会雑誌, 34, 2, 163, 163, (一社)日本インターベンショナルラジオロジー学会, Dec. 2019, [Peer-reviewed]
Japanese - Modalities and techniques used for stereotactic radiotherapy, intensity-modulated radiotherapy, and image-guided radiotherapy: A 2018 survey by the Japan Society of Medical Physics.
Yuichi Akino, Naoki Tohyama, Kazuhiko Akita, Masayori Ishikawa, Ryu Kawamorita, Masahiko Kurooka, Iori Sumida, Yuji Nakaguchi, Kazunori Miyaura, Mitsuhiro Nakamura
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 64, 182, 187, Aug. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Over the last several decades, there have been great advances in radiotherapy with the development of new technologies and modalities, and radiotherapy trends have changed rapidly. To comprehend the current state of radiotherapy in Japan, the QA/QC 2016-2017 Committee of the Japan Society of Medical Physics set up an intensity-modulated radiotherapy/image-guided radiotherapy (IMRT/IGRT) working group and performed a Web-based survey to show the current status of radiotherapy in Japan. The Web-based questionnaire, developed using Google Forms, contained 42 items: 7 on stereotactic radiotherapy implementation, 4 on IMRT, 24 on IGRT, and 7 on respiratory motion management. The survey was conducted from 17 January to 9 March of 2018; in total, 335 institutions provided data. The results show that volumetric modulated arc therapy was used at a level comparable to that of static gantry IMRT. For IGRT, machine-integrated computed tomography (CT), including kilovoltage or megavoltage cone-beam CT and megavoltage CT, was used at many institutions in conjunction with target-based image registration. For respiratory motion management, breath holding was the most commonly used technique. Our hope is that multi-institutional surveys such as this one will be conducted periodically to elucidate the current status of radiotherapy and emerging developments in this field. If our questionnaire was distributed worldwide, in the same format, then global trends in radiotherapy could be better understood. - DNA damage induction during localized chronic exposure to an insoluble radioactive microparticle.
Yusuke Matsuya, Yukihiko Satou, Nobuyuki Hamada, Hiroyuki Date, Masayori Ishikawa, Tatsuhiko Sato
Scientific reports, 9, 1, 10365, 10365, 17 Jul. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Insoluble radioactive microparticles emitted by the incident at the Fukushima nuclear power plant have drawn keen interests from the viewpoint of radiation protection. Cs-bearing particles have been assumed to adhere in the long term to trachea after aspirated into respiratory system, leading to heterogeneous dose distribution within healthy tissue around the particles. However, the biological effects posed by an insoluble radioactive particle remain unclear. Here, we show cumulative DNA damage in normal human lung cells proximal and distal to the particle (β-ray and γ-ray-dominant areas, respectively) under localized chronic exposure in comparison with uniform exposure. We put a Cs-bearing particle into a microcapillary tip and placed it onto a glass-base dish containing fibroblast or epithelial cells cultured in vitro. A Monte Carlo simulation with PHITS code provides the radial distribution of absorbed dose-rate around the particle, and subsequently we observed a significant change in nuclear γ-H2AX foci after 24 h or 48 h exposure to the particle. The nuclear foci in the cells distal to the particle increased even under low-dose-rate exposure compared with uniform exposure to 137Cs γ-rays, which was suppressed by a treatment with a scavenger of reactive oxygen species. In contrast, such focus formation was less manifested in the exposed cells proximal to the particle compared with uniform exposure. These data suggest that the localized exposure to a Cs-bearing particle leads to not only disadvantage to distal cells but also advantage to proximal cells. This study is the first to provide quantitative evaluation for the spatial distribution of DNA double strand breaks after the heterogeneous chronic exposure to a Cs-bearing particle in comparison with uniform Cs exposure. - Relationship Between Tube Voltage and Physical Image Quality of Pulmonary Nodules on Chest Radiographs Obtained Using the Bone-Suppression Technique.
Satoshi Takagi, Tatsuya Yaegashi, Masayori Ishikawa
Academic radiology, 26, 7, e174-e179, Jul. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal - Feasibility study on energy-dependent neutron flux monitor using multi-core SOF detector
Masayori Ishikawa, Kentaro Baba, Ryo Ogawara, Naoto Shimizu, Yoshinori Sakurai
2019 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (NSS/MIC), 2019
English, International conference proceedings - 3D Transformation Matrix Calculation and Pixel Intensity Normalization for the Dual Focus Tracking System
Kenneth Sutherland, Toshiyuki Hamada, Masayori Ishikawa, Naoki Miyamoto, Masahiro Mizuta, Hiroyuki Date, Hiroki Shirato
Journal of Medical and Biological Engineering, 2019, [Peer-reviewed]
English, Scientific journal - Feasibility study on real-time dosimetry during IVR procedur
M. Ishikawa
Japanese Journal of Interventional Radiology, 32, 4, 19, 25, 2018, [Peer-reviewed] - Consideration of Dose Error in Dynamic MLC IMRT Using MLC Speed Control with Dose Rate Change.
Hideki Kojima, Makoto Takigami, Tomohiro Asano, Yasuhiro Hatanaka, Kazuhiro Aizawa, Masayori Ishikawa
Nihon Hoshasen Gijutsu Gakkai zasshi, 73, 5, 382, 388, 2017, [Peer-reviewed], [Corresponding author], [Domestic magazines]
Japanese, Scientific journal, In dynamic multi-leaf collimator (MLC) intensity-modulated radiotherapy (IMRT), the accuracy of delivered dose is influenced by the positional accuracy of the moving MLC. In order to assess the accuracy of the delivered dose during dynamic MLC IMRT, the delivered dose error in dynamic MLC IMRT using the MLC speed control with dose rate change was investigated. Sweeping gap sequence irradiation was performed with constant MLC leaf speed at 0.6 to 5 cm/s or changed MLC speed (4 steps). The positional accuracy of the moving MLC was evaluated from the trajectory log file. Absorbed dose measurements with sweeping field (Field size: 10 cm×10 cm, MLC leaf speed: 0.6 to 2.7 cm/s, MLC leaf gap width: 0.2 to 2.0 cm) were performed. The delivered dose error at each gap width was evaluated according to MLC leaf speed change. MLC positional errors and changes in delivered dose according to MLC leaf speed were within 0.07 mm and 0.6%, respectively, for all measurements. Beam hold-off did not occur under any conditions. We confirmed that TrueBeam can regulate MLC leaf speed below the maximum limit (2.5 cm/s) by changing the dose rate in real-time during irradiation in dynamic MLC IMRT. MLC gap error during irradiation was estimated within 0.2 mm at the maximum dose rate from the results of absolute dose measurements using dynamic MLC irradiation. In conclusion, TrueBeam can use the maximum dose rate for the treatment planning of dynamic MLC IMRT, which has an advantage of shorter treatment time. - Expectation for continuous innovation in medical physics field and the way of medical device development
M. Ishikawa
Japanese Journal of Clinical Radiology, 62, 2, 257, 263, 2017, [Peer-reviewed], [Invited], [Lead author, Corresponding author]
Japanese - 自由行動マウスの複数組織における時計遺伝子発現のin vivo追跡定量化 (Best articles of the year)
浜田俊幸, ケネスリーサザーランド, 石川正純, 宮本直樹, 本間さと, 白土博樹, 本間研一
The Hokkaido Journal of Medical Science, 91, 2, Nov. 2016, [Peer-reviewed] - Early clinical experience utilizing scintillator with optical fiber (SOF) detector in clinical boron neutron capture therapy: its issues and solutions
Masayori Ishikawa, Tetsuya Yamamoto, Akira Matsumura, Junichi Hiratsuka, Shin-Ichi Miyatake, Itsuro Kato, Yoshinori Sakurai, Hiroaki Kumada, Shubhechha J. Shrestha, Koji Ono
RADIATION ONCOLOGY, 11, 105, Aug. 2016, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal - Signal pulse emulation for scintillation detectors using Geant4 Monte Carlo with light tracking simulation
R. Ogawara, M. Ishikawa
Review of Scientific Instruments, 87, 7, Epub. 075114, 01 Jul. 2016, [Peer-reviewed], [Corresponding author]
English, Scientific journal - In vivo imaging of clock gene expression in multiple tissues of freely moving mice.
Toshiyuki Hamada, Kenneth Sutherland, Masayori Ishikawa, Naoki Miyamoto, Sato Honma, Hiroki Shirato, Ken-Ichi Honma
Nature communications, 7, 11705, 11705, 10 Jun. 2016, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal - 照射中と4DCT撮像時の肺内マーカー移動の比較
原田慶一, 加藤徳雄, 井上哲也, 鬼丸力也, 清水伸一, 白土博樹, 鈴木隆介, 宮本直樹, 石川正純
Japanese Journal of Radiology, 34, Supplement, 10, 10, (公社)日本医学放射線学会, 25 Feb. 2016
Japanese - 呼吸性移動の複雑さと対策:最新の動体追跡放射線治療
宮本直樹, 高尾聖心, 原田慶一, 石川正純, 鈴木隆介, 松浦妙子, 牧永彩乃, 井上哲也, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹
日本放射線腫瘍学会高精度放射線外部照射部会学術大会プログラム・抄録集, 29th, 46, 2016
Japanese - Optimization of helical acquisition parameters to preserve uniformity of mouse whole body using multipinhole collimator in single-photon emission computed tomography
Naoyuki Ukon, Naoki Kubo, Masayori Ishikawa, Songji Zhao, Nagara Tamaki, Yuji Kuge
Results in Physics, 6, 659, 663, 2016, [Peer-reviewed]
English, Scientific journal - Feasibility study on signal separation for spontaneous alpha decay in LaBr3:Ce scintillator by signal peak-to-charge discrimination
R. Ogawara, M. Ishikawa
REVIEW OF SCIENTIFIC INSTRUMENTS, 86, 8, Epub. 085108, Aug. 2015, [Peer-reviewed], [Corresponding author]
English, Scientific journal - Application of radiosurgical techniques to produce a primate model of brain lesions.
Jun Kunimatsu, Naoki Miyamoto, Masayori Ishikawa, Hiroki Shirato, Masaki Tanaka
Frontiers in systems neuroscience, 9, APR, 67, 67, Frontiers Research Foundation, 24 Apr. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal - Development of a wavelength-separated type scintillator with optical fiber (SOF) dosimeter to compensate for the Cerenkov radiation effect
Masayori Ishikawa, Naomi Nagase, Taeko Matsuura, Junichi Hiratsuka, Ryusuke Suzuki, Naoki Miyamoto, Kenneth Lee Sutherland, Katsuhisa Fujita, Hiroki Shirato
JOURNAL OF RADIATION RESEARCH, 56, 2, 372, 381, Mar. 2015, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal - Application of an ultraminiature thermal neutron monitor for irradiation field study of accelerator-based neutron capture therapy
Masayori Ishikawa, Kenichi Tanaka, Satrou Endo, Masaharu Hoshi
JOURNAL OF RADIATION RESEARCH, 56, 2, 391, 396, Mar. 2015, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal - Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells
Seiichiro Ishihara, Motoaki Yasuda, Akihiro Ishizu, Masayori Ishikawa, Hiroki Shirato, Hisashi Haga
ONCOTARGET, 6, 7, 4602, 4614, Mar. 2015, [Peer-reviewed]
English, Scientific journal - A motion-compensated image filter for low-dose fluoroscopy in a real-time tumor-tracking radiotherapy system
Naoki Miyamoto, Masayori Ishikawa, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
JOURNAL OF RADIATION RESEARCH, 56, 1, 186, 196, Jan. 2015, [Peer-reviewed]
English, Scientific journal - 【放射線治療活用BOOK 2014】 (DIVISION-3)これからの放射線治療の展望 最新の動体追跡放射線治療装置
宮本 直樹, 石川 正純, 松浦 妙子, 井上 哲也, 加藤 徳雄, 清水 伸一, 鬼丸 力也, 梅垣 菊男, 白土 博樹
Rad Fan, 12, 15, 75, 77, (株)メディカルアイ, Dec. 2014
Japanese - Design, development of water tank-type lung phantom and dosimetric verification in institutions participating in a phase I study of stereotactic body radiation therapy in patients with T2N0M0 non-small cell lung cancer: Japan Clinical Oncology Group trial (JCOG0702)
Teiji Nishio, Hiroki Shirato, Masayori Ishikawa, Yuki Miyabe, Satoshi Kito, Yuichirou Narita, Rikiya Onimaru, Satoshi Ishikura, Yoshinori Ito, Masahiro Hiraoka
JOURNAL OF RADIATION RESEARCH, 55, 3, 600, 607, May 2014, [Peer-reviewed]
English, Scientific journal - Coating extracellular matrix proteins on a (3-aminopropyl)triethoxysilane-treated glass substrate for improved cell culture
Hiro-taka Masuda, Seiichiro Ishihara, Ichiro Harada, Takeomi Mizutani, Masayori Ishikawa, Kazushige Kawabata, Hisashi Haga
BIOTECHNIQUES, 56, 4, 172, 179, Apr. 2014, [Peer-reviewed]
English, Scientific journal - 北海道大学病院における髄膜腫に対する強度変調放射線治療(IMRT)の初期成績
西川由記子, 原田慶一, 西岡健太郎, 安田耕一, 井上哲也, 土屋和彦, 小野寺俊輔, 木下留美子, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹, 鈴木隆介, 石川正純
Jpn J Radiol, 32, Supplement, 5, 5, (公社)日本医学放射線学会, 25 Feb. 2014
Japanese - Design, development of water tank-type lung phantom and dosimetric verification in institutions participating in a phase I study of stereotactic body radiation therapy in patients with T2N0M0 non-small cell lung cancer: Japan Clinical Oncology Group trial
Nishio T, Shirato H, Ishikawa M, Miyabe Y, Kito S, Narita Y, Onimaru R, Ishikura S, Ito Y, Hiraoka M
J Radiat Res, 55, 3, 600, 7, 2014, [Peer-reviewed] - Clinical application of scintillator with optical fiber detector as a real-time thermal neutron monitor during boron neutron capture therapy
M.Ishikawa, K.Ono, A.Matsumura, T.Yamamoto, J.Hiratsuka, S.Miyatake, I.Kato, Y.Sakurai, H.Kumada
Book of Abstracts for the 7th Korea-Japan Joint Meeting on Medical Physics, The Korean Society of Medical Physics, 129, 2014
English, International conference proceedings - Dose-volume analysis for respiratory toxicity in intrathoracic esophagealcancer patients treated with definitive chemoradiotherapy using extended fields
Satoshi Tanabe, Miyako Myojin, Shinichi Shimizu, Masaharu Fujino, Hiroaki Takahashi, Hiroki Shirato, Yoichi M. Ito, Masayori Ishikawa, Masao Hosokawa
Journal of Radiation Research, 54, 6, 1085, 1094, Nov. 2013, [Peer-reviewed]
English, Scientific journal - Lung Cancer Cells That Survive Ionizing Radiation Show Increased Integrin alpha 2 beta 1-and EGFR-Dependent Invasiveness
Xue Li, Seiichiro Ishihara, Motoaki Yasuda, Takeshi Nishioka, Takeomi Mizutani, Masayori Ishikawa, Kazushige Kawabata, Hiroki Shirato, Hisashi Haga
PLOS ONE, 8, 8, e70905, Aug. 2013, [Peer-reviewed]
English, Scientific journal - β1-integrin via NF-κB signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer
Jin-Min Nam, Kazi M. Ahmed, Sylvain Costes, Hui Zhang, Yasuhito Onodera, Adam B. Olshen, Kanako C. Hatanaka, Rumiko Kinoshita, Masayori Ishikawa, Hisataka Sabe, Hiroki Shirato, Catherine C. Park
Breast Cancer Research, 15, 4, R60, 25 Jul. 2013, [Peer-reviewed]
English, Scientific journal - 医療情報誘導治療の最新 リアルタイム4次元放射線治療の―スーパー特区の成果―
白土博樹, 鬼丸力也, 清水伸一, 石川正純, 宮本直樹, SUTHERLAND Ken, 鈴木隆介, 寅松千枝
映像情報Medical, 45, 7, 619, 623, 01 Jul. 2013
Japanese - Integration of a real-time tumor monitoring system into gated proton spot-scanning beam therapy: An initial phantom study using patient tumor trajectory data
Taeko Matsuura, Naoki Miyamoto, Shinichi Shimizu, Yusuke Fujii, Masumi Umezawa, Seishin Takao, Hideaki Nihongi, Chie Toramatsu, Kenneth Sutherland, Ryusuke Suzuki, Masayori Ishikawa, Rumiko Kinoshita, Kenichiro Maeda, Kikuo Umegaki, Hiroki Shirato
MEDICAL PHYSICS, 40, 7, 071729, Jul. 2013, [Peer-reviewed]
English, Scientific journal - What is the appropriate size criterion for proton radiotherapy for hepatocellular carcinoma? A dosimetric comparison of spot-scanning proton therapy versus intensity-modulated radiation therapy
Chie Toramatsu, Norio Katoh, Shinichi Shimizu, Hideaki Nihongi, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Ryusuke Suzuki, Kenneth Sutherland, Rumiko Kinoshita, Rikiya Onimaru, Masayori Ishikawa, Kikuo Umegaki, Hiroki Shirato
RADIATION ONCOLOGY, 8, 48, Mar. 2013, [Peer-reviewed]
English, Scientific journal - フィルム線量解析における読取装置不安定性に起因する誤差の低減方法
石川 正純, 小島 秀樹, 橘 英伸, 鈴木 隆介, 峯村 俊行, 遠山 尚紀, 成田 雄一郎, 西尾 禎治, 石倉 聡
日本医学放射線学会学術集会抄録集, 72回, S407, S407, (公社)日本医学放射線学会, Feb. 2013
Japanese - beta 1-integrin via NF-kappa B signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer
Jin-Min Nam, Kazi M. Ahmed, Sylvain Costes, Hui Zhang, Yasuhito Onodera, Adam B. Olshen, Kanako C. Hatanaka, Rumiko Kinoshita, Masayori Ishikawa, Hisataka Sabe, Hiroki Shirato, Catherine C. Park
BREAST CANCER RESEARCH, 15, 4, 2013, [Peer-reviewed]
English, Scientific journal - Can 4DCT Imaging Predict Lung Motion During Stereotactic Body Radiation Therapy?
Harada K, Katoh N, Suzuki R, Inoue T, Omimaru R, Shimizu S, Miyamoto N, Ishikawa M, Shirato H
International Journal of Radiation Oncology Biology Physics, 87, 2, S67, 2013, [Peer-reviewed] - マルチベンダに対応した放射線治療計画管理システムの開発
辻 真太朗, 谷川原 綾子, 鈴木 隆介, 宮崎 智夫, 藤田 勝久, 石川 正純, 白土 博樹
医療情報学連合大会論文集, 32回, 1444, 1445, (一社)日本医療情報学会, Nov. 2012
Japanese - Simulation for a Real-time Positioning System for Radiotherapy Based on Annihilation Gamma-rays’ Detection from a Radiopharmaceutical Concentrated Tumor
Kaneko JH, Takada E, Hara Y, Fujita F, Yamaguchi T, Kubo N, Ishikawa M, Shirato H
PROGRESS IN NUCLEAR SCIENCE AND TECHNOLOGY, 3, 124, 126, Atomic Energy Society of Japan, Oct. 2012, [Peer-reviewed]
English - 一方向X線透視による低被曝・省スペース型動体追跡装置の開発
宮本直樹, 石川正純, SUTHERLAND Kenneth, 鈴木隆介, 松浦妙子, 高尾聖心, 寅松千枝, 二本木英明, 清水伸一, 梅垣菊男, 白土博樹
医学物理 Supplement, 32, 3, 281, 282, 13 Sep. 2012
Japanese - 体内複数マーカを用いた高精度ゲーティング照射法の基礎検討
大友可奈子, 宮本直樹, SUTHERLAND Kenneth, 鈴木隆介, 松浦妙子, 鬼丸力也, 清水伸一, 梅垣菊男, 白土博樹, 石川正純
医学物理 Supplement, 32, 3, 155, 156, 13 Sep. 2012
Japanese - 陽子線スキャニング照射における体内マーカーによる線量遮蔽のTCPを用いた評価
前田憲一郎, 松浦妙子, 高尾聖心, SUTHERLAND Kenneth, 寅松千枝, 二本木英明, 宮本直樹, 石川正純, 清水伸一, 梅垣菊男, 白土博樹
医学物理 Supplement, 32, 3, 101, 102, 13 Sep. 2012
Japanese - Biological effect of dose distortion by fiducial markers in spot-scanning proton therapy with a limited number of fields: A simulation study
Taeko Matsuura, Kenichiro Maeda, Kenneth Sutherland, Taisuke Takayanagi, Shinichi Shimizu, Seishin Takao, Naoki Miyamoto, Hideaki Nihongi, Chie Toramatsu, Yoshihiko Nagamine, Rintaro Fujimoto, Ryusuke Suzuki, Masayori Ishikawa, Kikuo Umegaki, Hiroki Shirato
MEDICAL PHYSICS, 39, 9, 5584, 5591, Sep. 2012, [Peer-reviewed]
English, Scientific journal - A New Brain Positron Emission Tomography Scanner With Semiconductor Detectors for Target Volume Delineation and Radiotherapy Treatment Planning in Patients With Nasopharyngeal Carcinoma
Norio Katoh, Koichi Yasuda, Tohru Shiga, Masakazu Hasegawa, Rikiya Onimaru, Shinichi Shimizu, Gerard Bengua, Masayori Ishikawa, Nagara Tamaki, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 82, 4, E671, E676, Mar. 2012, [Peer-reviewed]
English, Scientific journal - Real-time 4-D radiotherapy for lung cancer
Hiroki Shirato, Rikiya Onimaru, Masayori Ishikawa, Jun-ichi Kaneko, Tsuguhide Takeshima, Kenta Mochizuki, Shinichi Shimizu, Kikuo Umegaki
CANCER SCIENCE, 103, 1, 1, 6, Jan. 2012, [Peer-reviewed]
English - Real-time Tumor-tracking Radiation Therapy for Lymphoma of the Stomach
Katoh N, Suzuki R, Shimizu S, Inoue T, Yasuda K, Onimaru R, Kimura R, Kato M, Ishikawa M, Shirato H
International Journal of Radiation Oncology Biology Physics, 84, 3, S722, 2012, [Peer-reviewed] - Simulation for a Real-time Positioning System for Radiotherapy Based on Annihilation
Junichi H. Kaneko, Eiji Takada, Yu Hara, Fumiyuki Fujita, Toru Yamaguchi, Naoki Kubo, Masayori Ishikawa, Hiroki Shirato
Progress in Nuclear Science and Technology, 3, 104, 108, 2012, [Peer-reviewed]
English, Scientific journal, （全体概要）
腫瘍に対する放射線治療の際に呼吸等によって腫瘍が移動し、治療用放射線が正常組織に照射されることがある。それを防ぐために少数の放射線検出器で腫瘍の移動を測定し、特定の位置に腫瘍があるときのみ治療用放射線を照射するシステムについて検討し、可能性を示した。
（担当部分概要）pp.124-126
可能性検討全般に参加した。
（著者：Junichi H. Kaneko, Eiji Takada, Yu Hara, Fumiyuki Fujita, Toru Yamaguchi, Naoki Kubo, Masayori Ishikawa, Hiroki Shirato） - Improvement of tracking accuracy and stability by recursive image processing in real-time tumor-tracking radiotherapy system
Naoki Miyamoto, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Rumiko Kinoshita, Shinichi Shimizu, Rikiya Onimaru, Kikuo Umegaki, Hiroki Shirato, Masayori Ishikawa
MEDICAL IMAGING 2012: IMAGE-GUIDED PROCEDURES, ROBOTIC INTERVENTIONS, AND MODELING, 8316, 83160, 2012, [Peer-reviewed]
English, International conference proceedings - ACCURATE ANALYSIS OF THE CHANGE IN VOLUME, LOCATION, AND SHAPE OF METASTATIC CERVICAL LYMPH NODES DURING RADIOTHERAPY
Seishin Takao, Shigeru Tadano, Hiroshi Taguchi, Koichi Yasuda, Rikiya Onimaru, Masayori Ishikawa, Gerard Bengua, Ryusuke Suzuki, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81, 3, 871, 879, Nov. 2011, [Peer-reviewed]
English, Scientific journal - Optimization of fluoroscopy parameters using pattern matching prediction in the real-time tumor-tracking radiotherapy system
Naoki Miyamoto, Masayori Ishikawa, Gerard Bengua, Kenneth Sutherland, Ryusuke Suzuki, Suguru Kimura, Shinichi Shimizu, Rikiya Onimaru, Hiroki Shirato
PHYSICS IN MEDICINE AND BIOLOGY, 56, 15, 4803, 4813, Aug. 2011, [Peer-reviewed]
English, Scientific journal - Long-term Outcomes of Fractionated Stereotactic Radiotherapy for Intracranial Skull Base Benign Meningiomas in Single Institution
Shunsuke Onodera, Hidefumi Aoyama, Norio Katoh, Hiroshi Taguchi, Kouichi Yasuda, Daisuke Yoshida, Ken Surtherland, Ryusuke Suzuki, Masayori Ishikawa, Bengua Gerard, Shunsuke Terasaka, Hiroki Shirato
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 41, 4, 462, 468, Apr. 2011, [Peer-reviewed]
English, Scientific journal - A feasibility study of a molecular-based patient setup verification method using a parallel-plane PET system
Satoshi Yamaguchi, Masayori Ishikawa, Gerard Bengua, Kenneth Sutherland, Teiji Nishio, Satoshi Tanabe, Naoki Miyamoto, Ryusuke Suzuki, Hiroki Shirato
PHYSICS IN MEDICINE AND BIOLOGY, 56, 4, 965, 977, Feb. 2011, [Peer-reviewed], [Corresponding author]
English, Scientific journal - Detection of patient setup errors with a portal image - DRR registration software application
Kenneth Sutherland, Masayori Ishikawa, Gerard Bengua, Yoichi M. Ito, Yoshiko Miyamoto, Hiroki Shirato
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 12, 3, 2, 15, 2011, [Peer-reviewed], [Corresponding author]
English, Scientific journal - Optimization of fluoroscopy parameters using pattern matching prediction in the real-time tumor-tracking radiotherapy system
Miyamoto, N., Ishikawa, M., Bengua, G., Sutherland, K., Suzuki, R., Kimura, S., Shimizu, S., Onimaru, R., Shirato, H.
Physics in Medicine and Biology, 56, 15, 4803, 13, 2011, [Peer-reviewed]
Scientific journal - Accurate analysis of the change in volume, location, and shape of metastatic cervical lymph nodes during radiotherapy
Takao, S., Tadano, S., Taguchi, H., Yasuda, K., Onimaru, R., Ishikawa, M., Bengua, G., Suzuki, R., Shirato, H.
International Journal of Radiation Oncology Biology Physics, 81, 3, 871, 9, 2011, [Peer-reviewed]
Scientific journal - RADIATION PNEUMONITIS AFTER HYPOFRACTIONATED RADIOTHERAPY: EVALUATION OF THE LQ(L) MODEL AND DIFFERENT DOSE PARAMETERS
Gerben R. Borst, Masayori Ishikawa, Jasper Nijkamp, Michael Hauptmann, Hirk Shirato, Gerard Bengua, Rikiya Onimaru, A. de Josien Bois, Joos V. Lebesque, Jan-Jakob Sonke
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 77, 5, 1596, 1603, Aug. 2010, [Peer-reviewed]
English, Scientific journal - Measurement of microdosimetric spectra produced from a 290 MeV/n Spread Out Bragg Peak carbon beam
Satoru Endo, Masashi Takada, Hiroki Tanaka, Yoshihiko Onizuka, Kenichi Tanaka, Nobuyuki Miyahara, Hiromi Baba, Ayumu Oishi, Masayori Ishikawa, Masaharu Hoshi, Shinzo Kimura, Masakazu Minematsu, Yuki Morimune, Yasuaki Kojima, Kiyoshi Shizuma
RADIATION AND ENVIRONMENTAL BIOPHYSICS, 49, 3, 469, 475, Aug. 2010, [Peer-reviewed]
English, Scientific journal - EVALUATION OF THE EFFECTIVENESS OF THE STEREOTACTIC BODY FRAME IN REDUCING RESPIRATORY INTRAFRACTIONAL ORGAN MOTION USING THE REAL-TIME TUMOR-TRACKING RADIOTHERAPY SYSTEM
Gerard Bengua, Masayori Ishikawa, Kenneth Sutherland, Kenji Horita, Rie Yamazaki, Katsuhisa Fujita, Rikiya Onimaru, Noriwo Katoh, Tetsuya Inoue, Shunsuke Onodera, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 77, 2, 630, 636, Jun. 2010, [Peer-reviewed]
English, Scientific journal - Paternal monoenergetic neutron exposure results in abnormal sperm, and embryonal lethality and transgenerational tumorigenesis in mouse F-1 offspring
Hiromitsu Watanabe, Megumi Toyoshima, Masayori Ishikawa, Kenji Kamiya
ONCOLOGY REPORTS, 23, 5, 1351, 1360, May 2010, [Peer-reviewed]
English, Scientific journal - High Dose Three-Dimensional Conformal Boost Using the Real-Time Tumor Tracking Radiotherapy System in Cervical Cancer Patients Unable to Receive Intracavitary Brachytherapy
Hee Chul Park, Shinichi Shimizu, Akio Yonesaka, Kazuhiko Tsuchiya, Yasuhiko Ebina, Hiroshi Taguchi, Norio Katoh, Rumiko Kinoshita, Masayori Ishikawa, Noriaki Sakuragi, Hiroki Shirato
YONSEI MEDICAL JOURNAL, 51, 1, 93, 99, Jan. 2010, [Peer-reviewed]
English, Scientific journal - A parameter study of pencil beam proton dose distributions for the treatment of ocular melanoma utilizing spot scanning
Kenneth Sutherland, Satoshi Miyajima, Hiroyuki Date, Hiroki Shirato, Masayori Ishikawa, Masao Murakami, Mitsuru Yamagiwa, Paul Bolton, Toshiki Tajima
Radiological Physics and Technology, 3, 1, 16, 22, 1, Jan. 2010, [Peer-reviewed]
English, Scientific journal - Radiation pneumonitis after hypofractionated radiotherapy: Evaluation of the LQ(L) model and different dose parameters
Borst, G.R., Ishikawa, M., Nijkamp, J., Hauptmann, M., Shirato, H., Bengua, G., Onimaru, R., De Josien Bois, A., Lebesque, J.V., Sonke, J.-J.
International Journal of Radiation Oncology Biology Physics, 77, 5, 1596, 603, 2010, [Peer-reviewed]
Scientific journal - Evaluation of the effectiveness of the stereotactic body frame in reducing respiratory intrafractional organ motion using the real-time tumor-tracking radiotherapy system.
Bengua G, Ishikawa M, Sutherland K, Horita K, Yamazaki R, Fujita K, Onimaru R, Katoh N, Inoue T, Onodera S, Shirato H
Int J Radiat Oncol Biol Phys, 77, 2, 630, 6, 2010, [Peer-reviewed] - Stereotactic Radiotherapy for Intracranial Nonacoustic Schwannomas Including Facial Nerve Schwannoma
Kentaro Nishioka, Daisuke Abo, Hidefumi Aoyama, Yasushi Furuta, Rikiya Onimaru, Shunsuke Onodera, Yutaka Sawamura, Masayori Ishikawa, Satoshi Fukuda, Hiroki Shirato
International Journal of Radiation Oncology Biology Physics, 75, 5, 1415, 1419, 5, 01 Dec. 2009, [Peer-reviewed]
Scientific journal - Development of a miniature neutron beam monitor for boron neutron capture therapy
M., Komeda, H., Kumada, M., Ishikawa, T., Nakamura, K., Yamamoto, A., Matsumura
Applied Radiation and Isotopes, 67, 254-257, Elsevier, Jul. 2009, [Peer-reviewed]
English, Scientific journal - Radiation pneumonitis in patients treated for malignant pulmonary lesions with hypofractionated radiation therapy
Gerben R. Borst, Masayori Ishikawa, Jasper Nijkamp, Michael Hauptmann, Hiroki Shirato, Rikiya Onimaru, Michel M. van den Heuvel, Jose Belderbos, Joos V. Lebesque, Jan-Jakob Sonke
RADIOTHERAPY AND ONCOLOGY, 91, 3, 307, 313, Jun. 2009, [Peer-reviewed]
English, Scientific journal - A feasibility study of novel plastic scintillation dosimetry with pulse-counting mode
M. Ishikawa, G. Bengua, K. L. Sutherland, J. Hiratsuka, N. Katoh, S. Shimizu, H. Aoyama, K. Fujita, R. Yamazaki, K. Horita, H. Shirato
PHYSICS IN MEDICINE AND BIOLOGY, 54, 7, 2079, 2092, Apr. 2009, [Peer-reviewed]
English, Scientific journal - Measurement of (63)Ni produced in Cu samples by the Hiroshima atomic bomb (vol 273, pg 517, 2007)
S. Shibata, K. Takamiya, Y. Ota, N. Nogawa, Y. Ito, T. Shibata, M. Hoshi, S. Endo, H. Hasai, S. Fujita
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 279, 2, 699, 699, Feb. 2009
English, Scientific journal - Stereotactic radiotherapy for intracranial nonacoustic schwannomas including facial nerve schwannoma.
Nishioka K, Abo D, Aoyama H, Furuta Y, Onimaru R, Onodera S, Sawamura Y, Ishikawa M, Fukuda S, Shirato H
Int J Radiat Oncol Biol Phys, 75, 5, 1415, 9, 2009, [Peer-reviewed] - Radiation pneumonitis in patients treated for malignant pulmonary lesions with hypofractionated radiation therapy.
Borst G. R, Ishikawa M, Nijkamp J, Hauptmann M, Shirato H, Onimaru R, van den Heuvel M. M, Belderbos J, Lebesque J. V, Sonke J. J
Radiother Oncol, 91, 3, 307, 13, 2009, [Peer-reviewed] - Can the Real-time Tumor-tracking Radiotherapy Give the Planned Dose to the Tumor? DVH Analysis Based on Measured Real-time Tracking Data
Ishikawa M, Sutherland KL, Bengua G, Suzuki R, Miyamoto N, Katoh N, Shimizu S, Onimaru R, Aoyama H, Shirato
International Journal of Radiation Oncology Biology Physics, 75, 3, S590, S591, 2009, [Peer-reviewed] - A real-time dynamic-MLC control algorithm for delivering IMRT to targets undergoing 2D rigid motion in the beam's eye view
Ryan McMahon, Ross Berbeco, Seiko Nishioka, Masayori Ishikawa, Lech Papiez
MEDICAL PHYSICS, 35, 9, 3875, 3888, Sep. 2008, [Peer-reviewed]
English, Scientific journal - Real-time tumor-tracking radiotherapy for adrenal tumors
Norio Katoh, Rikiya Onimaru, Yusuke Sakuhara, Daisuke Abo, Shinichi Shimizu, Hiroshi Taguchi, Yoshiaki Watanabe, Nobuo Shinohara, Masayori Ishikawa, Hiroki Shirato
RADIOTHERAPY AND ONCOLOGY, 87, 3, 418, 424, Jun. 2008, [Peer-reviewed]
English, Scientific journal - Three-dimensional intrafractional motion of breast during tangential breast irradiation monitored with high-sampling frequency using a real-time tumor-tracking radiotherapy system
Rumiko Kinoshita, Shinichi Shimizu, Hiroshi Taguchi, Norio Katoh, Masaharu Fujino, Rikiya Onimaru, Hidefumi Aoyama, Fumi Katoh, Tokuhiko Omatsu, Masayori Ishikawa, Hiroki Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 70, 3, 931, 934, Mar. 2008, [Peer-reviewed]
English, Scientific journal - RTRT-based evaluation of the effectiveness of the stereotactic body frame in reducing intrafraction organ motion
Bengua G, Ishikawa M, Sutherland K, Horita K, Yamazaki R, Fujita K, Onimaru R, Shimizu S, Shirato
International Journal of Radiation Oncology Biology Physics, 72, 1, S610, S611, 2008, [Peer-reviewed] - A new positron emission tomography with semiconductor detectors for target volume delineation and radiotherapy treatment planning in patients with nasopharyngeal carcinoma
Katoh N, Shiga T, Hasegawa M, Onimaru R, Yasuda K, Shimizu S, Bengua G, Ishikawa M, Tamaki N, Shirato
International Journal of Radiation Oncology Biology Physics, 72, 1, S589, S590, 2008, [Peer-reviewed] - Microdosimetric evaluation of secondary particles in a phantom produced by carbon 290 MeV/nucleon ions at HIMAC
Satoru Endo, Masashi Takada, Yoshihiko Onizuka, Kenichi Tanaka, Naoko Maeda, Masayori Ishikawa, Nobuyuki Miyahara, Naofumi Hayabuchi, Kiyoshi Shizuma, Masaharu Hoshi
JOURNAL OF RADIATION RESEARCH, 48, 5, 397, 406, Sep. 2007, [Peer-reviewed]
English, Scientific journal - Microdosimetric study for secondary neutrons in phantom produced by a 290 MeV/nucleon carbon beam
Satoru Endo, Kenichi Tanaka, Masashi Takada, Yoshihiko Onizuka, Nobuyuki Miyahara, Tatsuhiko Sato, Masayori Ishikawa, Naoko Maeda, Naofurni Hayabuchi, Kiyoshi Shizuma, Masaharu Hoshi
MEDICAL PHYSICS, 34, 9, 3571, 3578, Sep. 2007, [Peer-reviewed]
English, Scientific journal - Tumor induction by monoenergetic neutrons in B6C3F1 mice
Hiromitsu Watanabe, Naoki Kashimoto, Junko Kajimura, Masayori Ishikawa, Kenji Kamiya
JOURNAL OF RADIATION RESEARCH, 48, 3, 205, 210, May 2007, [Peer-reviewed]
English, Scientific journal - Feasibility study of real-time tumor-tracking radiotherapy for adrenal tumors: Three-dimensional movement of internal fiducial gold markers measured in supine and prone patient positions
Katoh N, Onimaru R, Shimizu S, Abo D, Sakuhara Y, Taguchi H, Osaka Y, Gerard B, Ishikawa M, Shirato
International Journal of Radiation Oncology Biology Physics, 69, 3, S675, 2007, [Peer-reviewed] - Microdosimetric evaluation of the 400 MeV/nucleon carbon beam at HIMAC
S Endo, K Tanaka, M Ishikawa, M Hoshi, Y Onizuka, M Takada, H Yamaguchi, N Hayabuchi, N Maeda, K Shizuma
MEDICAL PHYSICS, 32, 12, 3843, 3848, Dec. 2005, [Peer-reviewed]
English, Scientific journal - Development of a wide-range paired scintillator with optical fiber neutron monitor for BNCT irradiation field study
M Ishikawa, H Kumada, K Yamamoto, J Kaneko, G Bengua, H Unesaki, Y Sakurai, K Tanaka, T Kosako
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 551, 2-3, 448, 457, Oct. 2005, [Peer-reviewed]
English, Scientific journal - [Feasibility study on a noninvasive measurement system for boron concentration.].
Ishikawa M, Hirasawa M, Tomitani T, Murayama H, Hoshi M
Igaku butsuri : Nihon Igaku Butsuri Gakkai kikanshi = Japanese journal of medical physics : an official journal of Japan Society of Medical Physics, 25, 1, 3, 12, 1, 2005, [Peer-reviewed]
Japanese, The kinematics of boron compounds in vivo is crucial to fully and safely utilize boron neutron capture therapy. In this paper, we proposed a prompt gamma-ray Compton scatter camera (PG-CSC), which can evaluate the 3-D kinematics of boron compounds without invasion. This PG-CSC combines a Compton camera with prompt gamma-ray analysis. The results of its design optimization and tests using simulations showed that one-hour-measurement was sufficient to evaluate a 3-D boron concentration distribution in a rat's brain with the resolution of 1mm in FWHM. - An ultra-long global-local grouping 1-D MSGC for very-large-area gas detector
Hisako Niko, Hiroyuki Takahashi, Kaoru Fujita, Masaharu Nakazawa, Masayori Ishikawa, Michihiro Furusaka, Takashi Ino, Masakazu Kanazawa
IEEE Nuclear Science Symposium Conference Record, 2, 1205, 1207, 2005, [Peer-reviewed]
English, International conference proceedings - Application of an ultra-miniature thermal neutron monitor for BNCT irradiation field study
Masayori Ishikawa, Hiroaki Kumada, Kazuyoshi Yamamoto, Junichi H. Kaneko, Hiroyuki Takahashi
IEEE Nuclear Science Symposium Conference Record, 5, 2917, 2919, 2005, [Peer-reviewed]
English, International conference proceedings - Development of Real-time Thermal Neutron Monitor for Boron Neutron Capture Therapy
M. Ishikawa, H. Kumada, K. Ono, Y. Sakurai, Y. Machijima, H. Takahashi
Ionizing Radiation, 31, 4, 279, 286, 2005, [Peer-reviewed] - Motivation Styles to Speak Out, Decision Rules, and Group Size as Determinants of Group Decision Making: Simulation of Meetings
Nireka Adachi, Masayori Ishikawa, Koichi E. Okamoto
GAMING, SIMULATIONS, AND SOCIETY, 149, 158, 2005, [Peer-reviewed]
English, International conference proceedings - An ultra-long global-local grouping 1-D MSGC for very-large-area gas detector
Hisako Niko, Hiroyuki Takahashi, Kaoru Fujita, Masaharu Nakazawa, Masayori Ishikawa, Michihiro Furusaka, Takashi Ino, Masakazu Kanazawa
2005 IEEE Nuclear Science Symposium Conference Record, Vols 1-5, 1205, 1207, 2005, [Peer-reviewed]
English, International conference proceedings - Application of an ultra-miniature thermal neutron monitor for BNCT irradiation field study
Masayori Ishikawa, Hiroaki Kumada, Kazuyoshi Yamamoto, Junichi H. Kaneko, Hiroyuki Takahashi
2005 IEEE Nuclear Science Symposium Conference Record, Vols 1-5, 5, 2917, 2919, 2005, [Peer-reviewed]
English, International conference proceedings - Development of real-time thermal neutron monitor using boron-loaded plastic scintillator with optical fiber for boron neutron capture therapy
M Ishikawa, K Ono, Y Sakurai, H Unesaki, A Uritani, G Bengua, T Kobayashi, K Tanaka, T Kosako
APPLIED RADIATION AND ISOTOPES, 61, 5, 775, 779, Nov. 2004, [Peer-reviewed]
English, Scientific journal - Upgrade of scintillator with optical fiber detector for real-time neutron flux monitor using compensation of gamma-ray and dead-time correction
M. Ishikawa, K. Ono, H. Unesaki, T. Kobayashi, Y. Sakurai, K. Tanaka, T. Kosako
KURRI Progress Report, 126-, 2004, [Peer-reviewed]
English - セミパラチンスクの核実験場近郊住民の放射線影響
星 正治, 高田 純, 金 隆史, 石川 正純, 川野 徳幸, 峠岡 康幸, 新田 由美子, イリダナ・テレウハン, 岡本 哲治, 武市 宣雄, 山田 英雄, ヴァレリ・ステパネンコ, 早川 式彦, 木村 昭郎, 山本 政儀, 吉川 勲, 高辻 俊宏, ナイラ・チャイジュヌソバ, カズベック・アプサリコフ, ボリス・グシェフ, ムラト・テレウオフ, ザクシバ・ズマジーロフ, 片山 博昭, 豊田 新
広島大学原爆放射線医科学研究所年報, 44, 141, 141, 広島大学原爆放射線医科学研究所, Sep. 2003
Japanese - Measurement of residual Eu-152 activity induced by atomic bomb neutrons in Nagasaki and the contribution of environmental neutrons to this activity
K Shizuma, S Endo, M Hoshi, J Takada, M Ishikawa, K Iwatani, H Hasai, T Oka, S Fujita, T Watanabe, T Yamashita, T Imanaka
JOURNAL OF RADIATION RESEARCH, 44, 2, 133, 139, Jun. 2003, [Peer-reviewed]
English, Scientific journal - Energy-dependent RBE of neutrons to induce micronuclei in root-tip cells of Allium cepa onion irradiated as dry dormant seeds and seedlings
W Zhang, K Fujikawa, S Endo, M Ishikawa, M Ohtaki, H Ikeda, M Hoshi
JOURNAL OF RADIATION RESEARCH, 44, 2, 171, 177, Jun. 2003, [Peer-reviewed]
English, Scientific journal - Development of real-time thermal neutron flux monitor during boron neutron capture therapy
M. Ishikawa, K. Ono, H. Unesaki, T. Kobayashi, Y. Sakurai, K. Tanaka, T. Kosako
KURRI Progress Report, 140, Apr. 2003
English, Scientific journal - Change of radiation quality on lateral direction
Y. Onizuka, S. Endo, M. Ishikawa, M. Hoshi, S. Sakurai, T. Kobayashi, H. Utsumi, N. Hayabuchi, T. Takatsuji, H. Yamaguchi, M. Takada, K. Fujikawa, N. Maeda, K. Tanaka
KURRI Progress Report, 122, 01 Apr. 2003 - Dosimetry of fission neutrons in a 1-W reactor, UTR-KINKI
S Endo, E Yoshida, Y Yoshitake, T Horiguchi, WY Zhang, K Fujikawa, M Hoshi, T Itoh, M Ishikawa, K Shizuma
JOURNAL OF RADIATION RESEARCH, 43, 4, 381, 386, Dec. 2002, [Peer-reviewed]
English, Scientific journal - Relative biological effectiveness of fission neutrons for producing micronuclei in the root-tip cells of onion seedlings after irradiation as dry seeds
WY Zhang, S Endo, M Ishikawa, H Ikeda, M Hoshi
JOURNAL OF RADIATION RESEARCH, 43, 4, 397, 403, Dec. 2002, [Peer-reviewed]
English, Scientific journal - Irradiation characteristics of BNCT using near-threshold Li-7(p, n)Be-7 direct neutrons: application to intra-operative BNCT for malignant brain tumours
K Tanaka, T Kobayashi, Y Sakurai, Y Nakagawa, M Ishikawa, M Hoshi
PHYSICS IN MEDICINE AND BIOLOGY, 47, 16, 3011, 3032, Aug. 2002, [Peer-reviewed]
English, Scientific journal - NbSi2 coating on niobium using molten salt
RO Suzuki, M Ishikawa, K Ono
JOURNAL OF ALLOYS AND COMPOUNDS, 336, 1-2, 280, 285, Apr. 2002, [Peer-reviewed]
English, Scientific journal - Feasibility study for accelerator-based intra-operative BNCT using near-threshold Li-7(p,n) Be-7 direct neutrons
K Tanaka, T Kobayashi, Y Nakagawa, Y Sakurai, M Ishikawa, M Hoshi
RESEARCH AND DEVELOPMENT IN NEUTRON CAPTURE THERAPY, 213, 219, 2002, [Peer-reviewed]
English, International conference proceedings - Real-time estimation of neutron flux during BNCT treatment using plastic scintillation detector with optical fiber
M Ishikawa, N Unesaki, T Kobayashi, Y Sakurai, K Tanaka, S Endo, M Hoshi
RESEARCH AND DEVELOPMENT IN NEUTRON CAPTURE THERAPY, 443, 447, 2002, [Peer-reviewed]
English, International conference proceedings - The Feasibility of Intra-Operative BNCT using Near-Threshold 7Li(p、n)7Be Direct Neutrons
T.Kobayashi, K.Tanaka, Y.Sakurai, Y.Nakagawa, M.Ishikawa, M.Hoshi
KURRI Prog. Rep, 2001, 166, 0, 2002
English, Research institution - The Validation of the Simulation Calculation Method for the Near-threshold 7Li(p、n)7Be and 7Li(p、p’g)7Li Reactions in BNCT
T.Kobayashi, K.Tanaka, Y.Sakurai, Y.Nakagawa, M.Ishikawa, M.Hoshi
KURRI Prog. Rep, 2001, 167, 0, 2002
English, Research institution - Optimization technique for a prompt gamma-ray SPECT collimator system
M Ishikawa, T Kobayashi, Y Sakurai, K Kanda
JOURNAL OF RADIATION RESEARCH, 42, 4, 387, 400, Dec. 2001, [Peer-reviewed]
English, Scientific journal - Analytical evaluating method of B-10(n,ay)Li-7 prompt gamma-ray spectrum for measuring absorbed dose distribution in boron neutron capture therapy
M Ishikawa, T Kobayashi, K Kanda
FRONTIERS IN NEUTRON CAPTURE THERAPY, VOLS 1 AND 2, 1145, 1149, 2001, [Peer-reviewed]
English, International conference proceedings - Real-time absorbed dose estimation system for BNCT by PG-SPECT
T Kobayashi, Y Sakurai, M Ishikawa
FRONTIERS IN NEUTRON CAPTURE THERAPY, VOLS 1 AND 2, 641, 645, 2001, [Peer-reviewed]
English, International conference proceedings - A statistical estimation method for counting of the prompt gamma-rays from B-10(n,alpha gamma)Li-7 reaction by analyzing the energy spectrum
M Ishikawa, T Kobayashi, K Kanda
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 453, 3, 614, 620, Oct. 2000, [Peer-reviewed]
English, Scientific journal - A noninvasive dose estimation system for clinical BNCT based on PG-SPECT - Conceptual study and fundamental experiments using HPGe and CdTe semiconductor detectors
T Kobayashi, Y Sakurai, M Ishikawa
MEDICAL PHYSICS, 27, 9, 2124, 2132, Sep. 2000, [Peer-reviewed]
English, Scientific journal - Electroless Coating of Fe3Si on Steels in the Moleten Salt
R. O. Suzuki, T. Nishibata, Y. Nagaso, K. Nakanishi, M. Ishikawa, K. Teranuma, K. Ono
Fluxes and Salts, 12, 17, Jun. 2000
English, International conference proceedings, Proc. of 6th Intern. Conf. on Molten Slags, Fluxes and Salts, (12-17 June 2000,
Stockholm, Sweden and Helsinki, Finland), ed. by S. Seetharaman and D. Sichen, paper 180. - MoSi2 coating on molybdenum using molten salt
RO Suzuki, M Ishikawa, K Ono
JOURNAL OF ALLOYS AND COMPOUNDS, 306, 1-2, 285, 291, Jun. 2000, [Peer-reviewed]
English, Scientific journal - Electroless coating of Fe3Si on steel in the molten salt
RO Suzuki, T Nishibata, K Nakanishi, M Ishikawa, K Ono
STEEL RESEARCH, 71, 4, 130, 137, Apr. 2000, [Peer-reviewed]
English, Scientific journal - On-line Absorbed Dose Estimation System for BNCT by PG-SPECT
T.Kobayashi, Y.Sakurai, M.Ishikawa
KURRI Prog. Rep, 1999, 179, 0, 2000
English, Research institution - Survey of external dose around the JCO facility using sugar samples and ESR method
Shiraishi, K, Kimura, S, Honehara, H, Takada, J, Ishikawa, M, Igarashi, Y, Aoyama, M, Komura, K, Nakajima, T
Adv. ESR Appl., 16, 9, 14, 2000, [Peer-reviewed]
English, Scientific journal
Other Activities and Achievements
- Advancement of integrated system for dose estimation in BNCT
櫻井良憲, 渡辺賢一, 吉橋幸子, 増田明彦, 石川正純, 納冨昭弘, 村田勲, 遠藤暁, 田中憲一, 宇野彰二, 眞正浄光, 笈田将皇, 林慎一郎, 田中浩基, 黒澤俊介, 谷森達, 高田淳史, 中村哲志, 高田卓志, 加茂前健, 道上宏之, 保田浩志, 黒木伸一郎, 井川和代, KURNS-EKR (Web), 17, 2023 - BNCTに関する総合的線量評価システムの構築
櫻井良憲, 瓜谷章, 石川正純, 納冨昭弘, 遠藤暁, 田中憲一, 眞正浄光, 笈田将皇, 林慎一郎, 田中浩基, 黒澤俊介, 谷森達, 中村哲志, 高田卓志, 保田浩志, 宇野彰二, 道上宏之, 村田勲, KURNS-EKR (Web), 6, 2020 - BNCTにおけるintra-fractional set-up errorの検討
玉利勇樹, 高田卓志, 栗原孝太, 石川正純, LEE Sutherland Kenneth, 櫻井良憲, 田中浩基, 鈴木実, 日本放射線腫瘍学会高精度放射線外部照射部会学術大会プログラム・抄録集, 32nd, 2019 - Expectation for continuous innovation in medical physics field and the way of medical device development
石川 正純, 臨床放射線, 62, 2, 257, 263, Feb. 2017
金原出版, Japanese - Tumor tracking approach
Masayori Ishikawa, Shubhechha J. Shrestha, Image-Based Computer-Assisted Radiation Therapy, 273, 292, 01 Jan. 2017
Springer Singapore, English - Clinical application and future vision of the real-time tumor-tracking radiotherapy
宮本直樹, 石川正純, 井上哲也, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹, 臨床放射線, 61, 2, 293‐302, 10 Feb. 2016
Japanese - Clinical application and future vision of the real-time tumor-tracking radiotherapy
宮本 直樹, 石川 正純, 井上 哲也, 臨床放射線, 61, 2, 293, 302, Feb. 2016
金原出版, Japanese - Target Residual Motion During Beam Delivery in Gated Irradiation Using Real Time Tumor Tracking Radiation Therapy System: Analysis of Simultaneous Motion of Multiple Internal Fiducial Markers
N. Miyamoto, M. Ishikawa, R. Suzuki, A. Makinaga, T. Matsuura, S. Takao, Y. Matsuzaki, T. Inoue, N. Katoh, S. Shimizu, R. Onimaru, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93, 3, E554, E554, Nov. 2015
English, Summary international conference - 新規動体追跡技術により可能になる3D imagingによる自由行動マウスの全身の遺伝子発現追跡定量法の開発
浜田 俊幸, 石川 正純, Sutherland Kenneth, 宮本 直樹, 白土 博樹, 本間 さと, 本間 研一, バイオイメージング, 24, 2, 114, 114, Sep. 2015
日本バイオイメージング学会, Japanese - Real time tracking radiotherapy (RTRT) system
Rikiya Onimaru, Shinichi Shimizu, Hiroki Shirato, Masayori Ishikawa, Stereotactic Body Radiation Therapy: Principles and Practices, 217, 224, 06 Aug. 2015 - 新規4D imagingによる自由行動マウスの全身の時計遺伝子発現制御機構の解析
浜田 俊幸, Sutherland Kenneth, 石川 正純, 宮本 直樹, 本間 さと, 白土 博樹, 本間 研一, 日本薬学会年会要旨集, 135年会, 2, 290, 290, Mar. 2015
(公社)日本薬学会, Japanese - SOF検出器によるBNCT治療中のリアルタイム熱中性子モニタリング
石川正純, 小野公二, 松村 明, 平塚純一, 宮武伸一, 櫻井良憲, 熊田博明, 日本放射線腫瘍学会 第27回学術大会 O-074 (2014.12.11-13) 横浜, Dec. 2014
Japanese - DynamicMLC照射時における線量率制御法が照射に与える影響に関する考察
小島秀樹, 瀧上誠, 水野文弥, 浅野友洋, 黒澤亮輔, 猪俣淳二, 石川正純, 日本放射線技術学会雑誌, 70, 9, 1020, 20 Sep. 2014
Japanese - リアルタイム熱中性子束モニタの開発と臨床応用
石川正純, 小野公二, 松村 明, 山本哲哉, 平塚純一, 宮武伸一, 加藤逸郎, 櫻井良憲, 古林 徹, 熊田博明, 日本中性子捕捉療法学会 第11回学術大会 一般演題34 (2014.07.05-06) 吹田, Jul. 2014
Japanese - 高精度放射線治療における呼吸性移動対策のコツとピットフォール RTRTによる呼吸性移動対策:有用性と今後の展望
宮本直樹, 石川正純, 井上哲也, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹, Rad Fan, 12, 3, 70-73,20, 25 Feb. 2014
Japanese - 頸部転移性骨腫瘍におけるスポットスキャニング照射法を用いた陽子線治療の線量分布評価
吉村 高明, 安田 耕一, 寅松 千枝, 高尾 聖心, 松浦 妙子, 二本木 英明, 木下 留美子, 鬼丸 力也, 白土 博樹, 石川 正純, Japanese Journal of Radiology, 32, Suppl., 7, 7, Feb. 2014
(公社)日本医学放射線学会, Japanese - 光ファイバ線量計によるIVR透視時のリアルタイム線量評価に関する基礎検討
石川正純, 松浦妙子, 作原祐介, 阿保大介, 中川啓治, 古畑優, IVR, 28, 4, 485, 485, 01 Oct. 2013
(一社)日本インターベンショナルラジオロジー学会, Japanese - 放射線照射後の乳癌再発に関わるシグナルの解析(Possible mechanisms of non-invasive to invasive phenotypic conversion of breast cancer cells upon radiation)
南 ジンミン, 小野寺 康仁, 石川 正純, 佐邊 壽孝, 白土 博樹, 日本癌学会総会記事, 72回, 219, 219, Oct. 2013
日本癌学会, English - 覚醒マウス嗅球および皮膚における時計遺伝子発現の4Dイメージング
浜田俊幸, 石川正純, SUTHERLAND K, 宮本直樹, 白土博樹, 本間さと, 本間研一, 日本生理学雑誌, 75, 4, 206, 207, 01 Jul. 2013
Japanese - Practical Method of Scanner Stability Compensation for Film Dosimetry
M. Ishikawa, H. Kojima, H. Tachibana, S. Tanabe, R. Suzuki, T. Minemura, N. Tohyama, Y. Narita, T. Nishio, S. Ishikura, MEDICAL PHYSICS, 40, 6, 246, Jun. 2013
English, Summary international conference - SU‐E‐J‐57: A Feasibility Study On Molecular‐Imaging‐Based Real‐Time Tumor Tracking for Gated Radiotherapy
M. Ishikawa, S. Tanabe, S. Yamaguchi, N. Ukon, T. Yamanaka, K. Sutherland, N. Miyamoto, R. Suzuki, N. Katoh, K. Yasuda, H. Shirato, Medical Physics, 40, 6, 162, Jun. 2013 - D-7-13 Development of Prediction System for Moving Tumor for Real-time Tumor Tracking Radiotherapy
Kawai Masaki, Demachi Kazuyuki, Ishikawa Masayori, Shirato Hiroki, Uesaka Mitsuru, Proceedings of the IEICE General Conference, 2013, 1, 74, 74, 05 Mar. 2013
The Institute of Electronics, Information and Communication Engineers, Japanese - トップランナーに聞く : 最先端の医療に挑む若手研究者への直撃インタビュー(25)放射線医学分野における先進医療機器開発 : 現場で役立つ研究開発を目指して
石川 正純, 最新医学, 68, 1, 131, 136, Jan. 2013
最新医学社, Japanese - SU‐E‐J‐42: Motion Adaptive Image Filter for Low Dose X‐Ray Fluoroscopy in the Real‐Time Tumor‐Tracking Radiotherapy System
N. Miyamoto, M. Ishikawa, K. Sutherland, R. Suzuki, T. Matsuura, S. Takao, C. Toramatsu, H. Nihongi, S. Shimizu, R. Onimaru, K. Umegaki, H. Shirato, Medical Physics, 39, 6, 3661, 3662, Jun. 2012 - Improvement of tracking accuracy and stability by recursive image processing in real-time tumor-tracking radiotherapy system
Naoki Miyamoto, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Rumiko Kinoshita, Shinichi Shimizu, Rikiya Onimaru, Kikuo Umegaki, Hiroki Shirato, Masayori Ishikawa, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8316, 83160, 01 May 2012
SPIE - マルチベンダに対応した放射線治療計画管理システムの開発
辻真太朗, 鈴木隆介, 安田耕一, 藤田勝久, 宮崎智夫, 石川正純, 白土博樹, 日本放射線技術学会総会学術大会予稿集, 68th, 134, 134, 29 Feb. 2012
(公社)日本放射線技術学会, Japanese - 胃悪性リンパ腫に対する迎撃照射とマーカー移動の解析
加藤徳雄, 鈴木隆介, 井上哲也, 安田耕一, 鬼丸力也, 清水伸一, 木村理奈, 石川正純, 白土博樹, 日本医学放射線学会総会抄録集, 71st, S316, S316, 29 Feb. 2012
(公社)日本医学放射線学会, Japanese - J241034 Development of Prediction System for Moving tumor by MSSA for Real-time Tumor tracking Radiation Therapy
KAWAI Masaki, DEMACHI Kazuyuki, ISHIKAWA Masayori, SHIRATO Hiroki, UESAKA Mitsuru, The Proceedings of Mechanical Engineering Congress, Japan, 2012, 0, _J241034, 1-_J241034-3, 2012
Currently, the area targeted by radiation therapy is wider than an actual tumor as the tumor moves during treatments Especially for a lung tumor, the radiation exposure to normal tissues is increased, as it tends to move more than other types of tumors One of the methods to reduce the exposure of normal tissues is RTRT (Real-time Tumor-tracking Radiation Therapy) In this research, we have attempted to predict the tumor motion using a prediction method called MSSA (Multi-channel Singular Spectrum Analysis) in the therapy This method reconstructs the time-series data with principal components and predicts the future data using the reconstructed data We predicted real tumor motions which were taken at Hokkaido University Hospital As a result, the errors between the predicted data and the raw data are about 1mm Also, we have developped the safety system with prediction This system is needed to stop the irradiation in case that the patient tumor moves dramatically such as cough or sneeze during a radiation therapy The result shows that the safety system can detect the unusual signal before a large movement, The Japan Society of Mechanical Engineers, Japanese - リアルタイム分子イメージングを用いた治療ビームゲーティングに関する基礎検討
右近直之, 棚邊哲史, 棚邊哲史, 山中琢, 山口哲, SUTHERLAND Kenneth, 鈴木隆介, 宮本直樹, 白土博樹, 石川正純, 医学物理 Supplement, 32, 3, 2012 - 陽子線高線量率ラインスキャニングの革新的技術の研究 陽子線スキャニングビームの体内照射位置確認システムの研究
石川正純, 陽子線高線量率ラインスキャニングの革新的技術の研究 平成23年度 総括研究報告書, 22-24, 2012
Japanese - 陽子線高線量率ラインスキャニングの革新的技術の研究 陽子線スキャニングビームの体内照射位置確認システムの研究
石川正純, 陽子線高線量率ラインスキャニングの革新的技術の研究 平成21−23年度 総合研究報告書, 36-40, 2012
Japanese - 食道癌IMRT(強度変調放射線治療)の初期経験
原田慶一, 井上哲也, 安田耕一, 加藤徳雄, 清水伸一, 白土博樹, BENGUA Gerard, 石川正純, 中積宏之, 結城敏志, 小松嘉人, 北海道外科雑誌, 56, 2, 176-177, 177, 20 Dec. 2011
北海道外科学会, Japanese - 5-224 Medical-Physicist and Radiation Treatment Quality Assurance Manager Course at Graduate School of Engineering and Graduate School of Medicine, Hokkaido University
FURUSAKA Michihiro, KIYANAGI Yoshiaki, SUMIYOSHI Takashi, SHIRATO Hiroki, ISHIKAWA Masayori, SUZUKI Ryusuke, Proceedings of Annual Conference of Japanese Society for Engineering Education, 23, 59, 356, 357, 22 Aug. 2011
公益社団法人日本工学教育協会, Japanese - Independent Quality Control and Quality Assurance Programs for IMRT
T. Minemura, Y. Narita, M. Tamura, M. Ishikawa, S. Ozawa, T. Miyagishi, T. Nishio, MEDICAL PHYSICS, 38, 6, 3548, Jun. 2011
English, Summary international conference - 本当は一年かかる原発処理--間違いだらけの放射能報道 (総力特集 東日本大震災 日本人の再出発)
石川 正純, 岡本 浩一, 文芸春秋, 89, 5, 202, 209, May 2011
文芸春秋, Japanese - 腫瘍の体内変動を考慮した放射線治療における照射法の検討
高尾聖心, 但野茂, BENGUA Gerard, 石川正純, 白土博樹, バイオエンジニアリング講演会講演論文集, 23rd, 23, 443-444, 444, 07 Jan. 2011
The Japan Society of Mechanical Engineers, Japanese - 9H-06 Optimal Treatment Plan for Radiotherapy considering Anatomical Changes of Tumor
TAKAO Seishin, TADANO Shigeru, BENGUA Gerard, ISHIKAWA Masayori, SHIRATO Hiroki, The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2010, 0, 443, 444, 2011
The Japan Society of Mechanical Engineers, Japanese - 頭頸部リンパ節腫瘍における放射線治療効果予測
高尾聖心, 但野茂, 田口大志, 安田耕一, 鬼丸力也, 石川正純, 鈴木隆介, GERARD Bengua, 白土博樹, 日本生体医工学会大会プログラム・論文集(CD−ROM), 50th, ROMBUNNO.O1-9-5, 2011
Japanese - 陽子線高線量率ラインスキャニングの革新的技術の研究 陽子線スキャニングビームの体内照射位置確認システムの研究
石川正純, 陽子線高線量率ラインスキャニングの革新的技術の研究 平成22年度 総括・分担研究報告書, 16, 30-33, 123, 2011
(財)医療機器センター情報サービス部, Japanese - がん医療の均てん化に資する放射線治療の推進及び品質管理に係る研究 放射線治療モダリティ別拠点病院支援プログラム及び品質管理に係る研究
石川正純, がん医療の均てん化に資する放射線治療の推進及び品質管理に係る研究 平成22年度 総括・分担研究報告書, 152-153, 2011
Japanese - 高精度治療技術による低リスク高線量放射線治療に関する臨床研究 肺の線量不均一補正の研究
石川正純, 高精度治療技術による低リスク高線量放射線治療に関する臨床研究 平成22年度 総括研究報告書, 23-25, 2011
Japanese - 診断X線領域における極微小光ファイバ線量計の基礎特性評価(第66回総会学術大会放射線防護・管理関連演題発表後抄録)
江口 菜弥帆, 石川 正純, 作原 祐介, 阿保 大介, 太田 真緒, Sutherland Kenneth, 白土 博樹, 放射線防護分科会会誌, 0, 31, 33, 33, 14 Oct. 2010
公益社団法人日本放射線技術学会, Japanese - The impact of 18F-fluoromisonidazole PET for H&N cancer and the applying for IMRT
YASUDA KOICHI, HASEGAWA MASAICHI, ONIMARU RIKIYA, KINOSHITA RUMIKO, KATO NORIO, TAGUCHI HIROSHI, SHIMIZU SHIN'ICHI, INOUE TETSUYA, ONODERA SHUNSUKE, MIZOGUCHI FUMIKI, AOYAMA HIDEFUMI, SHIRATO HIROKI, SHIGA SATORU, OKAMOTO SHOZO, TAMAKI NAGARA, ISHIKAWA MASAZUMI, SUTHERLAND KENNETH, BENGUA GERARD, MIYAMOTO NAOKI, SUZUKI TAKASUKE, Jpn J Radiol, 28, Supplement 1, 14, 14, 25 Jul. 2010
(公社)日本医学放射線学会, Japanese - 鼻腔・副鼻腔癌に対する超選択的動注を併用した根治的化学放射線療法
長谷川雅一, 安田耕一, 吉田大介, 加藤徳雄, 鬼丸力也, 浅野剛, 白土博樹, 本間明宏, 折舘伸彦, 福田諭, 石川正純, BENGUA Gerard, SUTHERLAND Kenneth, 宮本直樹, 鈴木隆介, Jpn J Radiol, 28, Supplement 1, 7, 7, 25 Jul. 2010
(公社)日本医学放射線学会, Japanese - 生物学的効果を考慮した治療計画—Dose Volume Histogram解析による考察—
関原和正, 石川正純, SUTHERLAND Kenneth, BENGUA Gerard, 宮本直樹, 鈴木隆介, 清水伸一, 白土博樹, Jpn J Radiol, 28, Supplement 1, 15, 15, 25 Jul. 2010
(公社)日本医学放射線学会, Japanese - 診断X線領域における極微小SOF線量計による被曝線量評価
石川正純, 江口菜弥帆, 作原大介, 阿保大介, 太田真緒, SUTHERLAND Kenneth, BENGUA Gerard, 鈴木隆介, 宮本直樹, 白土博樹, 日本医学放射線学会総会抄録集, 69th, S378, S378, 28 Feb. 2010
(公社)日本医学放射線学会, Japanese - Oligometastases症例に対する定位放射線治療の有用性についての検討
井上哲也, 加藤徳雄, 青山英史, 鬼丸力也, 石川正純, 田口大志, 白土博樹, 日本医学放射線学会総会抄録集, 69th, S193-S194, S194, 28 Feb. 2010
(公社)日本医学放射線学会, Japanese - 診断X線領域における極微小光ファイバ線量計の基礎特性評価
江口菜弥帆, 石川正純, 作原祐介, 阿保大介, 太田真緒, KENNETH Sutherland, 白土博樹, 日本放射線技術学会総会学術大会予稿集, 66th, 153-154, 154, 26 Feb. 2010
(公社)日本放射線技術学会, Japanese - Conceptual Design of PET-linac System for Molecular-guided Radiotherapy
M. Ishikawa, S. Yamaguchi, S. Tanabe, G. Bengua, K. Sutherland, R. Suzuki, N. Miyamoto, K. Nishijima, N. Katoh, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 78, 3, S674, S674, 2010
English, Summary international conference - Improvement of Tracking Accuracy and Stability with Utilizing a Color Image Intensifier in Real-time Tumor-tracking Radiotherapy System
N. Miyamoto, M. Ishikawa, G. Bengua, K. Sutherland, R. Suzuki, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 78, 3, S678, S678, 2010
English, Summary international conference - Feasibility Study on Molecular-imaging Based Tracking System for Lung Cancer Treatment
S. Tanabe, M. Ishikawa, S. Yamaguchi, G. Bengua, K. Sutherland, R. Suzuki, N. Miyamoto, N. Katoh, R. Onimaru, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 78, 3, S749, S749, 2010
English, Summary international conference - 高精度治療技術による低リスク高線量放射線治療に関する臨床研究 肺の線量不均一補正の研究
石川正純, 高精度治療技術による低リスク高線量放射線治療に関する臨床研究 平成21年度 総括研究報告書, 12, 2010
Japanese - がん医療の均てん化に資するがん診療連携拠点病院の機能強化に関する研究 放射線治療モダリティ別拠点病院支援プログラムに係る研究
石川正純, がん医療の均てん化に資するがん診療連携拠点病院の機能強化に関する研究 平成21年度 総括・分担研究報告書, 34-35, 2010
Japanese - 画像誘導放射線治療
白土博樹, 青山英史, 石川正純, 清水伸一, 鬼丸力也, 溝脇尚志, 日本癌治療学会誌, 44, 2, 256, 256, 14 Sep. 2009
(一社)日本癌治療学会, Japanese - 動体追跡放射線治療におけるX線透視条件の最適化
宮本直樹, SUTHERLAND Kenneth, 石川正純, 鈴木隆介, BENGUA Gerard, 木村傑, 清水伸一, 青山英史, 鬼丸力也, 白土博樹, 医学物理 Supplement, 29, 3, 150-151, Sep. 2009
Japanese - 対向型PET装置を用いた患者位置確認システムの開発—GEANT4基礎シミュレーション—
山口哲, 石川正純, 棚邊哲史, BENGUA Gerard, SUTHERLAND Kenneth, 青山英史, 武島嗣英, 白土博樹, 医学物理 Supplement, 29, 3, 174-175, Sep. 2009
Japanese - 動体追跡装置におけるコントラスト‐ノイズ比の測定方法の検討
木村傑, 宮本直樹, 石川正純, SUTHERLAND Kenneth, BENGUA Gerard, 鈴木隆介, 清水伸一, 青山英史, 鬼丸力也, 白土博樹, 医学物理 Supplement, 29, 3, 148-149, Sep. 2009
Japanese - 動体追跡装置を用いた肺定位照射時の投与線量解析—動体追跡データに基づくDVH解析—
石川正純, サザランド ケネス, ベングア ジェラード, 鈴木隆介, 宮本直樹, 加藤徳雄, 清水伸一, 鬼丸力也, 青山英史, 白土博樹, 日本放射線腫よう学会誌, 21, Supplement 1, 158, 19 Aug. 2009
Japanese - Oligometastases症例に対する定位放射線治療の有用性についての検討
井上哲也, 加藤徳雄, 青山英史, 鬼丸力也, 石川正純, 田口大志, 白土博樹, 日本放射線腫よう学会誌, 21, Supplement 1, 159, 19 Aug. 2009
Japanese - 新しい治療 画像誘導放射線治療(image‐guided radiotherapy:IGRT)
白土博樹, 青山英史, 鬼丸力也, 清水伸一, 石川正純, 西岡健, 治療学, 43, 7, 781-783, 783, 10 Jul. 2009
ライフサイエンス出版(株), Japanese - Performance measurement of the scintillator with optical fiber detector for boron neutron capture therapy
M. Komeda, H. Kumada, M. Ishikawa, T. Nakamura, K. Yamamoto, A. Matsumura, APPLIED RADIATION AND ISOTOPES, 67, 7-8, S254, S257, Jul. 2009
English - Predictive Simulation of tumor movement for Chasing Radiotherapy
DEMACHI KAZUYUKI, ZHU HAITAO, ISHIKAWA MASANAO, SHIRATO HIROKI, 日本AEM学会誌, 17, 2, 222-226, 226, 10 Jun. 2009
In this research, the Singular Spectrum Analysis (SSA) was applied for the prediction of time-series data. The prediction calculation were performed for the time-series data of the atmosphere temperature, the rank of star shining, and the displacement of a tumor in human lang. The prediction results showed good agreement with the measured data, then the validity of this method was verified. It can be said that this method is hopeful for the realization of the chasing radiotherapy., 日本AEM学会, Japanese - Predictive Simulation of tumor movement for Chasing Radiotherapy(
17th MAGDA Conference)
DEMACHI Kazuyuki, ZHU Haitao, ISHIKAWA Masanao, SHIRATO Hiroki, Journal of the Japan Society of Applied Electromagnetics, 17, 2, 222, 226, 10 Jun. 2009
In this research, the Singular Spectrum Analysis (SSA) was applied for the prediction of time-series data. The prediction calculation were performed for the time-series data of the atmosphere temperature, the rank of star shining, and the displacement of a tumor in human lang. The prediction results showed good agreement with the measured data, then the validity of this method was verified. It can be said that this method is hopeful for the realization of the chasing radiotherapy., The Japan Society Applied Electromagnetics and Mechanics, Japanese - Development of PID-TEPC
ENDO SATORU, TAKADA MASASHI, TANAKA HIROKI, ONIZUKA YOSHIHIKO, TANAKA KEN'ICHI, MIYAHARA NOBUYUKI, HOSHI MASAHARU, ISHIKAWA MASAYORI, KIMURA SHINZO, SHIZUMA KIYOSHI, NIRS−M (Natl Inst Radiol Sci), 226, 232-233, Jun. 2009
Japanese - A feasibility study of novel plastic scintillation dosimetry with pulse-counting mode
M. Ishikawa, G. Bengua, K. L. Sutherland, J. Hiratsuka, N. Katoh, S. Shimizu, H. Aoyama, K. Fujita, R. Yamazaki, K. Horita, H. Shirato, PHYSICS IN MEDICINE AND BIOLOGY, 54, 7, 2079, 2092, Apr. 2009
English - 体内臓器同期照射を目的とした次世代動体追跡装置の開発〜複数マーカ追跡への挑戦〜
石川正純, SUTHERLAND Kenneth, 宮本直樹, BENGUA Gerard, 清水伸一, 青山英史, 鬼丸力也, 木村傑, 白土博樹, 医学物理 Supplement, 29, 2, 194-195, Apr. 2009
Japanese - 体内臓器同期照射を目的とした次世代動体追跡装置の開発〜デジタル画像機器としての定量的評価〜
木村傑, 石川正純, SUTHERLAND Kenneth, 宮本直樹, BENGUA Gerard, 鈴木隆介, 清水伸一, 青山英史, 鬼丸力也, 白土博樹, 医学物理 Supplement, 29, 2, 196-197, Apr. 2009
Japanese - 体内臓器同期照射を目的とした次世代動体追跡装置の開発〜透視画像の歪みと位置計算誤差〜
宮本直樹, SUTHERLAND Kenneth, 石川正純, 鈴木隆介, BENGUA Gerard, 木村傑, 清水伸一, 青山英史, 鬼丸力也, 白土博樹, 医学物理 Supplement, 29, 2, 192-193, Apr. 2009
Japanese - 定位放射線治療のための消滅γ線計測に基づく腫瘍位置同定装置の概念設計
原裕, 島崎紘亘, 金子純一, 高田英治, 藤田文行, 久保直樹, 石川正純, 古坂道弘, 白土博樹, 医学物理 Supplement, 29, 2, 190-191, Apr. 2009
Japanese - 対向型PET装置を用いた分子イメージング動体追跡装置の開発〜18F点線源を用いた追跡精度の検証〜
棚邊哲史, 石川正純, 山口哲, 武島嗣英, 鈴木隆介, 宮本直樹, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹, 医学物理 Supplement, 29, 2, 101-102, Apr. 2009
Japanese - 炭素SOBPビームおよび生成フラグメント粒子のマイクロドシメトリ
遠藤暁, 高田真志, 田中浩基, 鬼塚昌彦, 田中憲一, 宮原信幸, 星正治, 石川正純, 木村真三, 靜間清, 医学物理 Supplement, 29, 2, 133-134, Apr. 2009
Japanese - 第3部 PET装置開発の展望(28)照射位置確認のためのOpen‐PET装置の開発—画像再構成の基礎シミュレーション—
山口哲, 石川正純, 棚邊哲史, BENGUA Gerard, SUTHERLAND Kenneth, 青山英史, 武島嗣英, 白土博樹, NIRS−R (Natl Inst Radiol Sci), 60, 137-138, Mar. 2009
Japanese - 18F‐FMISO PETを用いたIMRT dose painting planの試み
安田耕一, 白土博樹, 岡本祥三, 志賀哲, SUTHERLAND Ken, 加藤徳雄, 長谷川雅一, 鬼丸力也, BENGUA Gerard, 石川正純, 日本医学放射線学会総会抄録集, 68th, S267, S267, 28 Feb. 2009
(公社)日本医学放射線学会, Japanese - 上咽頭癌における半導体PET画像を用いた放射線治療計画
加藤徳雄, 志賀哲, 長谷川雅一, 鬼丸力也, 安田耕一, 清水伸一, ベングア ジェラード, 石川正純, 玉木長良, 白土博樹, 日本医学放射線学会総会抄録集, 68th, S307-S308, S308, 28 Feb. 2009
(公社)日本医学放射線学会, Japanese - 放射線治療用頭頸部固定具(シェル)使用時による固定精度の評価
高森清華, 堀田賢治, 斎藤英一, 山崎理衣, 藤田勝久, SUTHERLAND Kenneth, 石川正純, 日本放射線技術学会総会学術大会予稿集, 65th, 242, 27 Feb. 2009
Japanese - Detection of Patient Set-up Errors with a Portal Image - DRR Registration Software System
K. Sutherland, M. Ishikawa, G. Bengua, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75, 3, S600, S600, 2009
English, Summary international conference - 炭素SOBPビームおよび生成フラグメント粒子のマイクロドシメトリ
遠藤暁, 高田真志, 田中浩基, 鬼塚昌彦, 田中憲一, 宮原信幸, 星正治, 石川正純, 木村真三, 靜間清, 日本原子力学会中国・四国支部研究発表会要旨集, 3rd, 38-41, 2009
Japanese - 定位放射線治療による予後改善に関する研究 定位放射線治療による臨床試験の研究
白土博樹, 鬼丸力也, BENGUA Gerard, 石川正純, 井上哲也, 清水伸一, 木下留美子, 青山英史, 定位放射線治療による予後改善に関する研究 平成20年度 総括研究報告書, 12-13, 2009
Japanese - 高精度治療技術による低リスク高線量放射線治療に関する臨床研究 肺の線量不均一補正の研究
石川正純, 高精度治療技術による低リスク高線量放射線治療に関する臨床研究 平成20年度 総括研究報告書, 20-21, 2009
Japanese - 患者位置確認のためのイメージング装置の開発—Open‐PET装置の基礎シミュレーション—
山口哲, 石川正純, 棚邊哲史, GERARD Bengua, KENNETH Sutherland, 青山英史, 武島嗣英, 白土博樹, 日本放射線腫よう学会誌, 20, Supplement 1, 267, 22 Sep. 2008
Japanese - 分子イメージングを利用した患者位置確認のための対向型Open‐PET装置の製作と基礎検討
棚邊哲史, 石川正純, 山口哲, 武島嗣英, GERARD Bengua, KENNETH Sutherland, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹, 日本放射線腫よう学会誌, 20, Supplement 1, 268, 22 Sep. 2008
Japanese - LG-DRR patient setup verification for routine clinical application
KENNETH SUTHERLAND, ISHIKAWA MASAZUMI, GERARD BENGUA, ONIMARU RIKIYA, SHIMIZU SHIN'ICHI, AOYAMA HIDEFUMI, FUJITA KATSUHISA, YAMASAKI SATOI, SHIRATO HIROKI, 日本放射線腫よう学会誌, 20, Supplement 1, 264, 22 Sep. 2008
Japanese - SOF線量計によるIr‐192高線量率密封小線源治療時のin‐vivoリアルタイム線量測定
石川正純, 平塚純一, 長瀬尚巳, GERARD Bengua, KENNETH Sutherland, 加藤徳雄, 清水伸一, 鬼丸力也, 青山英史, 白土博樹, 日本放射線腫よう学会誌, 20, Supplement 1, 251, 22 Sep. 2008
Japanese - Intercomparison study on (152)Eu gamma ray and (36)Cl AMS measurements for development of the new Hiroshima-Nagasaki Atomic Bomb Dosimetry System 2002 (DS02)
M. Hoshi, S. Endo, K. Tanaka, M. Ishikawa, T. Straume, K. Komura, W. Ruehm, E. Nolte, T. Huber, Y. Nagashima, R. Seki, K. Sasa, K. Sueki, H. Fukushima, S. D. Egbert, T. Imanaka, RADIATION AND ENVIRONMENTAL BIOPHYSICS, 47, 3, 313, 322, Jul. 2008
English - Real time dosimetry for HDR brachytherapy using SOF dosimeter
ISHIKAWA Masayori, HIRATSUKA Junichi, NAGASE Naomi, OSAKA Yasuhiro, BENGUA Gerard, SHIRATO Hiroki, 医学物理 : 日本医学物理学会機関誌 = Japanese journal of medical physics : an official journal of Japan Society of Medical Physics, 28, 285, 286, 01 Apr. 2008
Japanese - Development of Molecular Imaging Device for patient setup : Preliminary simulation of Open-PET
YAMAGUCHI Satoshi, ISHIKAWA Masayori, TANABE Satoshi, BENGUA Gerard, SUTHERLAND Kenneth, AOYAMA Hidefumi, TAKESHIMA Tuguhide, SHIRATO Hiroki, 医学物理 : 日本医学物理学会機関誌 = Japanese journal of medical physics : an official journal of Japan Society of Medical Physics, 28, 256, 257, 01 Apr. 2008
Japanese - Feasibility Study on an Annihilation Gamma-rays Detection System for a Real-time Tumor-tracking Radiotherapy by Simulation
HARA Y, KANEKO J. H, TAKADA E, FUJITA F, KUBO N, ISHIKAWA M, FURUSAKA M, SHIRATO H, 医学物理 : 日本医学物理学会機関誌 = Japanese journal of medical physics : an official journal of Japan Society of Medical Physics, 28, 0, 283, 284, 01 Apr. 2008
Japanese - [非小細胞肺癌]画像誘導放射線治療と強度変調放射線治療
白土博樹, 鬼丸力也, 石川正純, 田口大志, 加藤徳雄, 清水伸一, MOOK肺癌の臨床, 2008-2009, 319-326, 31 Mar. 2008
Japanese - Radiation pneumonitis for stereotactic irradiated lung cancer patients: Is the LQ model valid for high doses per fraction?
G. R. Borst, H. Shirato, J. Nijkamp, R. Onimaru, M. Ishikawa, J. V. Lebesque, J. Sonke, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 72, 1, S68, S69, 2008
English, Summary international conference - 動体追跡照射治療への応用を目指したFDG計測システムの最適化設計
原裕, 金子純一, 高田英治, 藤田文行, 久保直樹, 石川正純, 古坂道弘, 白土博樹, 日本原子力学会北海道支部研究発表会講演要旨集, 26th, 4-5, 2008
Japanese - 定位放射線治療による予後改善に関する研究 T2N0M0非小細胞肺癌の体幹部放射線治療の線量増加試験に関する研究
白土博樹, 鬼丸力也, 田口大志, 加藤徳雄, 石川正純, 定位放射線治療による予後改善に関する研究 平成19年度 総括研究報告書, 9-10, 2008
Japanese - Radioactivity in atomic-bomb samples from exposure to environmental neutrons
S. Endo, K. Shizuma, K. Tanaka, M. Ishikawa, W. Ruehm, S. D. Egbert, M. Hoshi, HEALTH PHYSICS, 93, 6, 689, 695, Dec. 2007
English - ホウ素中性子捕捉療法のリアルタイム線量評価のための小型熱中性子モニタの性能評価
熊田博明, 米田政夫, 中村剛実, 山本和喜, 楠剛, 石川正純, 中川義信, 日本原子力学会秋の大会予稿集(CD−ROM), 2007, F12, 07 Sep. 2007
Japanese - Microdosimetric evaluation of secondary particles in a phantom produced by carbon 290 MeV/nucleon ions at HIMAC
Satoru Endo, Masashi Takada, Yoshihiko Onizuka, Kenichi Tanaka, Naoko Maeda, Masayori Ishikawa, Nobuyuki Miyahara, Naofumi Hayabuchi, Kiyoshi Shizuma, Masaharu Hoshi, JOURNAL OF RADIATION RESEARCH, 48, 5, 397, 406, Sep. 2007
English - IMRTとIGRT:Inverse Planningの理論と装置に求められる性能
石川正純, 鈴木恵士朗, 木下留美子, 藤田勝久, 山崎理衣, 笈田将皇, 白土博樹, 頭けい部癌, 33, 2, 64, 15 May 2007
Japanese - Tumor induction by monoenergetic neutrons in B6C3F1 mice
Hiromitsu Watanabe, Naoki Kashimoto, Junko Kajimura, Masayori Ishikawa, Kenji Kamiya, JOURNAL OF RADIATION RESEARCH, 48, 3, 205, 210, May 2007
English - Wide range and high spatial resolution In-Vivo dosimetory using ultraminiature plastic scintillator with pulse couting method
M. Ishikawa, Y. Osaka, J. Hiratsuka, G. Bengua, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69, 3, S45, S46, 2007
English, Summary international conference - プラスチックシンチレーションファイバー検出器の応答特性に関する基礎的検討
笈田将皇, 石川正純, 藤野賢治, 加藤徳雄, 田口大志, 白土博樹, 渡辺良晴, 日本放射線腫よう学会誌, 18, Supplement 1, 199, 25 Oct. 2006
Japanese - 極微小プラスチックシンチレータを用いた水吸収線量測定法の開発
石川正純, 笈田将皇, 加藤徳雄, 藤野賢治, 大坂康博, 白土博樹, 日本放射線腫よう学会誌, 18, Supplement 1, 199, 25 Oct. 2006
Japanese - 肺がん定位照射における計算アルゴリズムの違いによるリスク臓器の線量変化
鄭歩宏, 劉暁濱, 笈田将皇, 石川正純, 藤野賢治, 鬼丸力也, 白土博樹, 日本放射線腫よう学会誌, 18, Supplement 1, 201, 25 Oct. 2006
Japanese - 放射線治療への臨床応用を目的としたモンテカルロシミュレーションによるSOF検出器の応答特性
笈田将皇, 石川正純, 藤田勝久, 渡辺良晴, 日本放射線技術学会雑誌, 62, 9, 1237, 1237, 20 Sep. 2006
公益社団法人日本放射線技術学会, Japanese - 188 放射線治療への臨床応用を目的としたモンテカルロシミュレーションによるSOF検出器の応答特性(放射線治療 モンテカルロ,一般研究発表,日本放射線技術学会 第34回秋季学術大会)
笈田 将皇, 石川 正純, 藤田 勝久, 渡辺 良晴, 日本放射線技術學會雜誌, 62, 9, 1237, 1237, 20 Sep. 2006
公益社団法人日本放射線技術学会, Japanese - Overview of cancer treatment by radiation in Japan
Keiichi Nakagawa, Masayori Ishikawa, Mitsuru Uesaka, Tetsuo Saito, JOURNAL OF THE ATOMIC ENERGY SOCIETY OF JAPAN, 48, 6, 398, 402, Jun. 2006
Japanese - Overview of cancer treatment by radiation in Japan
Keiichi Nakagawa, Masayori Ishikawa, Mitsuru Uesaka, Tetsuo Saito, JOURNAL OF THE ATOMIC ENERGY SOCIETY OF JAPAN, 48, 6, 398, 402, Jun. 2006
Japanese - Evaluation for depth RBE for therapeutic carbon beam and secondary fragments
ENDO SATORU, ONIZUKA YOSHIHIKO, TAKADA MASASHI, TANAKA KEN'ICHI, HOSHI MASAHARU, ISHIKAWA MASAYORI, MIYAHARA NOBUYUKI, MAEDA NAOKO, HAYABUCHI NAOFUMI, NIRS−M (Natl Inst Radiol Sci), 192, 187-189, May 2006
Japanese - Reduction of prostate movement using orthogonal diagnostic x-rays of real-time tumor-tracking system and fiducial gold markers
M.Oita, M Ishikawa, R Onimaru, Y Osaka, H Aoyama, K Suzuki, M Fujino, Y Watanabe, K Fujita, H Shirato, K Miyasaka, Proceedings of 1st Hokkaido International Croscutting Symposium Molecular Bio-imaging and 4D Image-guided radiotherapy, 65, 65, 2006 - Reevaluation of the atomic bomb radiation exposure dosage in Hiroshima and Nagasaki. Exposure sample measured value and calculated value. chapter 10. Factor contributed at neutron measured value and calculated value. A. Field measurement of the neutron ba
ENDO AKIRA, TANAKA KEN'ICHI, ISHIKAWA MASAZUMI, KOMURA KAZUHISA, SHIZUMA KIYOSHI, HOSHI MASAHARU, 広島および長崎における原子爆弾放射線被曝線量の再評価 線量評価システム2002 下巻 平成18年, 736-740, 2006
Japanese - Reevaluation of the atomic bomb radiation exposure dosage in Hiroshima and Nagasaki Exposure sample measured value and calculated value Chapter 8 The thermal neutron radio activation measurement H. The comparison of the radio activation of 36Cl and 152Eu.
HOSHI MASAHARU, ENDO SATOSHI, TANAKA KEN'ICHI, ISHIKAWA MASAZUMI, STRAUME TORE, KOMURA KAZUHISA, RUEHM WERNER, NOLTE ECKEHART, HUBER THOMAS, NAGASHIMA YASUO, FUKUSHIMA HIROHITO, IMANAKA TETSUJI, 広島および長崎における原子爆弾放射線被曝線量の再評価 線量評価システム2002 下巻 平成18年, 590-599, 2006
Japanese - 超小型熱中性子束モニタの改良—異色発光シンチレータによるファイバの共有化—
石川正純, 熊田博明, BENGUA Gerard, 町島祐一, 高橋浩之, UTNL−R(東京大学大学院工学系研究科附属原子力工学研究施設), 0449, 7-8, 2006
Japanese - Development of a wide-range paired scintillator with optical fiber neutron monitor for BNCT irradiation field study
M Ishikawa, H Kumada, K Yamamoto, J Kaneko, G Bengua, H Unesaki, Y Sakurai, K Tanaka, T Kosako, NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 551, 2-3, 448, 457, Oct. 2005
English - Development of Real-time Thermal Neutron Monitor for Boron Neutron Capture Therapy
ISHIKAWA MASAYORI, TAKAHASHI HIROYUKI, ONO KOJI, SAKURAI YOSHINORI, KUMADA HIROAKI, MACHIJIMA YUICHI, 放射線, 31, 4, 279-285, 285, Oct. 2005
応用物理学会放射線分科会, Japanese - Feasibility study on a noninvasive measurement system for boron concentration
ISHIKAWA Masayori, HIRASAWA Masahiko, TOMITANI Takehiro, MURAYAMA Hideo, HOSHI Masaharu, Japanese journal of medical physics, 25, 1, 3, 12, 31 Mar. 2005
The kinematics of boron compounds in vivo is crucial to fully and safely utilize boron neutron capture therapy. In this paper, we proposed a prompt gamma-ray Compton scatter camera (PG-CSC), which can evaluate the 3-D kinematics of boron compounds without invasion. This PG-CSC combines a Compton camera with prompt gamma-ray analysis. The results of its design optimization and tests using simulations showed that one-hour-measurement was sufficient to evaluate a 3-D boron concentration distribution in a rat's brain with the resolution of 1mm in FWHM., Japan Society of Medical Physics, Japanese - Feasibility study on a noninvasive measurement system for boron concentration
ISHIKAWA MASAYORI, HIRASAWA MASAHIKO, TOMITANI TAKEHIRO, MURAYAMA HIDEO, HOSHI MASAHARU, 医学物理, 25, 1, 3, 12, 31 Mar. 2005
The kinematics of boron compounds in vivo is crucial to fully and safely utilize boron neutron capture therapy. In this paper, we proposed a prompt gamma-ray Compton scatter camera (PG-CSC), which can evaluate the 3-D kinematics of boron compounds without invasion. This PG-CSC combines a Compton camera with prompt gamma-ray analysis. The results of its design optimization and tests using simulations showed that one-hour-measurement was sufficient to evaluate a 3-D boron concentration distribution in a rat's brain with the resolution of 1mm in FWHM., Japan Society of Medical Physics, Japanese - YBO3中性子シンチレータのホウ素中性子捕捉療法用リアルタイム中性子モニターへの応用
山口達, 白石和正, 金子純一, 片桐政樹, 石川正純, 沢村晃子, 日本原子力学会春の年会要旨集, 43rd, 186, 11 Mar. 2005
Japanese - 高フォトンレーザアブレーションによる理論空間解像度を超えた微細加工技術
石川正純, 石丸伊知郎, 石井知彦, 井上祐介, 奥田貴啓, 藤井義樹, 精密工学会大会学術講演会講演論文集, 2005, B62, 01 Mar. 2005
Japanese - A stylized computational model of the head for the reference Japanese male
M Yamauchi, M Ishikawa, M Hoshi, MEDICAL PHYSICS, 32, 1, 85, 92, Jan. 2005
English - YBO3中性子シンチレータのホウ素中性子捕捉療法用リアルタイム中性子モニターへの応用
山口達, 白石和正, 金子純一, 片桐政樹, 石川正純, 沢村晃子, 日本原子力学会春の年会要旨集, 43rd, 2005 - Neutron Irradiation Field Measurement during Boron Neutron Capture Therapy
ISHIKAWA MASAYORI, TAKAHASHI HIROYUKI, KUMADA HIROAKI, SAKURAI YOSHINORI, MACHIJIMA YUICHI, 電気学会原子力研究会資料, NE-05, 6-10, 7-11, 11, 2005
Japanese - Bを含有した比例計数管による線質測定
鬼塚昌彦, 遠藤暁, 田中憲一, 桜井良憲, 石川正純, 高田真志, 前田直子, 早淵尚文, 高辻俊宏, 京都大学原子炉実験所学術講演会報文集, 39th, 97-100, Jan. 2005
Japanese - Development of real-time thermal neutron monitor using boron-loaded plastic scintillator with optical fiber for boron neutron capture therapy
M Ishikawa, K Ono, Y Sakurai, H Unesaki, A Uritani, G Bengua, T Kobayashi, K Tanaka, T Kosako, APPLIED RADIATION AND ISOTOPES, 61, 5, 775, 779, Nov. 2004
English - Risk Communication : Toward Creation of Fertile Risk Concepts and Fruitful Forums
ADACHI Nireka, ISHIKAWA Masayori, Japanese Journal of Health Physics, 39, 3, 160, 164, Sep. 2004
Japan Health Physics Society, Japanese - リスク・コミュニケーション:豊かなリスク概念と豊かな対話の場の生成へ向けて
足立にれか, 石川正純, 保健物理, 39, 3, 160-164, 164, Sep. 2004
Japan Health Physics Society, Japanese - イメージングプレートを用いたIVR術下における患者の体内線量分布評価
小宮祐治, 遠藤三郎, 飯本武志, 石川正純, 杉浦紳之, 小佐古敏荘, 理工学における同位元素・放射線研究発表会要旨集, 41st, 67, Jul. 2004
Japanese - Mutation Spectrum of Accelerated Heavy Ions
高辻俊宏, 松瀬美智子, 中沢由華, 星正治, 高田純, 石川正純, 遠藤暁, 野島久美恵, 古沢佳也, NIRS-M (Natl Inst Radiol Sci), 173, 154, 155, Apr. 2004
Japanese - Measurement of radiation quality on lateral direction
Y. Onizuka, S. Endo, M. Ishikawa, M. Hoshi, S. Sakurai, T. Kobayashi, H. Utsumi, N. Hayabuchi, T. Takatsuji, H. Yamaguchi, M. Takada, K. Fujikawa, N. Maeda, K. Tanaka, KURRI Progress Report, 136, 01 Apr. 2004 - Mutation Spectrum of Accelerated Heavy Ions
TAKATSUJI TOSHIHIRO, MATSUSE MICHIKO, NAKAZAWA YUKA, HOSHI MASAHARU, TAKADA JUN, ISHIKAWA MASAZUMI, ENDO SATORU, NOJIMA KUMIE, FURUSAWA YOSHINARI, NIRS−M (Natl Inst Radiol Sci), 173, 154-155, Apr. 2004
Japanese - ホウ素中性子捕捉療法用リアルタイム熱中性子束モニタの改良
石川正純, 小野公二, 桜井良憲, 宇根崎博信, 古林徹, 小佐古敏荘, 日本原子力学会春の年会要旨集, 42nd, 187, 11 Mar. 2004
Japanese - コンプトンカメラ方式によるガンマ線イメージング:中性子線を利用した工学的応用
平沢雅彦, 石川正純, 富谷武浩, 高橋浩之, 首藤経世, 森国城, 尾鍋秀昭, 野宮聖一郎, UTNL−R(東京大学大学院工学系研究科附属原子力工学研究施設), 0433, 1-2, 02 Feb. 2004
Japanese - Microdosimetry of neutron field for boron neutron capture therapy at Kyoto University Reactor
S Endo, Y Onizuka, M Ishikawa, M Takada, Y Sakurai, T Kobayashi, K Tanaka, M Hoshi, K Shizuma, RADIATION PROTECTION DOSIMETRY, 110, 1-4, 641, 644, 2004
English - A Numerical Simulation Method for Analysis on Meeting Procedure : - Development of Models on Group Decision Making in Organizations -
ISHIKAWA Masayori, ADACHI Nireka, OKAMOTO Koichi E, SOCIOTECHNICA, 2, 0, 362, 369, 2004
Recently, the matter which betrays national reliance such as a illegal act by the large company greatly breaks out frequently. These matters are common in the point that a contravention was being done through the agreement at a Meeting. Therefore, paying attention to the decision procedure in the group decision making, it is necessary to clarify the proper decision procedure to control systematic violation. This research aims at building an experiment tool to examine a proper group decision making procedure. As the experiment tool, a numerical simulation by the computer is used and various ..., 社会技術研究会 - S-1-4 Tumorigenicity by monoenergetic neutron in B6C3F1 mice(Present and Future of Researches on Biological Effects of Neutrons, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
WATANABE Hiromitsu, KASHIWABARA Shoji, KASHIMOTO Naoki, UESAKA Toshihiro, KATOH Osamu, ISHIKAWA Masayori, Journal of radiation research, 44, 4, 373, 373, 15 Dec. 2003
The Japan Radiation Research Society, English - 単色中性子照射のB6C3F1マウスでの発癌性
渡辺敦光, 柏原昌次, 樫本尚樹, 上坂敏弘, 加藤修, 石川正純, 日本放射線影響学会大会講演要旨集, 46th, 70, 06 Oct. 2003
Japanese - 放射線先端医学実験施設研究概況
渡辺敦光, 石川正純, 新田由美子, 藤本成明, 鈴木文男, 竹岡清二, 北川和英, 菅慎治, 両角真里子, 広島大学原爆放射線医科学研究所年報, 44, 165-166,403-404, Sep. 2003
Japanese - 附属国際放射線情報センター研究概況
早川式彦, 星正治, 高田純, 金隆史, 新田由美子, 石川正純, 川野徳幸, 峠岡康幸, 山内光利, 広島大学原爆放射線医科学研究所年報, 44, 135-164,375-401, Sep. 2003
Japanese - SOFによる検出器によるBNCT治療中のリアルタイム熱中性子束評価
石川正純, 小野公二, 宇根崎博信, 古林徹, 桜井良憲, 田中憲一, 遠藤暁, 星正治, KURRI KR, 95, 48-52, Aug. 2003
Japanese - ホウ素含有壁によるマイクロドジメトリー
鬼塚昌彦, 遠藤暁, 石川正純, 桜井良憲, 古林徹, 高田真志, 前田直子, 早淵尚文, 高辻俊宏, KURRI KR, 95, 53-58, Aug. 2003
Japanese - Measurement of residual Eu-152 activity induced by atomic bomb neutrons in Nagasaki and the contribution of environmental neutrons to this activity
K Shizuma, S Endo, M Hoshi, J Takada, M Ishikawa, K Iwatani, H Hasai, T Oka, S Fujita, T Watanabe, T Yamashita, T Imanaka, JOURNAL OF RADIATION RESEARCH, 44, 2, 133, 139, Jun. 2003
English - Energy-dependent RBE of neutrons to induce micronuclei in root-tip cells of Allium cepa onion irradiated as dry dormant seeds and seedlings
W Zhang, K Fujikawa, S Endo, M Ishikawa, M Ohtaki, H Ikeda, M Hoshi, JOURNAL OF RADIATION RESEARCH, 44, 2, 171, 177, Jun. 2003
English - The basic research of the quality of radiation and dose assessment of the heavy ion radiotherapy field.
ONIZUKA MASAHIKO, ENDO AKIRA, TAKADA SHINJI, ISHIKAWA MASAZUMI, UEHARA SHUZO, HAYABUCHI NAOFUMI, MAEDA NAOKO, SHIZUMA KIYOSHI, YAMAGUCHI HIROSHI, NIRS−M (Natl Inst Radiol Sci), 166, 236-238, Apr. 2003
Japanese - ホウ素含有壁によるマイクロドジメトリー (平成14年度専門研究会報告書「中性子捕捉療法システムの高度化」)
鬼塚 昌彦, 遠藤 暁, 石川 正純, KURRI-KR, 95, 53, 58, 04 Mar. 2003
京都大学原子炉実験所, Japanese - SOF検出器によるBNCT治療中のリアルタイム熱中性子束評価 (平成14年度専門研究会報告書「中性子捕捉療法システムの高度化」)
石川 正純, 小野 公二, 宇根崎 博信, KURRI-KR, 95, 48, 52, 04 Mar. 2003
京都大学原子炉実験所, Japanese - Erratum: Relative biological effectiveness of fission neutrons for producing micronuclei in the root-tip cells of onion seedlings after irradiation as dry seeds (Journal of Radiation Research (2000) 43:4 (397-403))
Zhang, W., Endo, S., Ishikawa, M., Ikeda, H., Hoshi, M., Journal of Radiation Research, 44, 1, 81, 81, 01 Mar. 2003 - Relative biological effectiveness of fission neutrons for producing micronuclei in the root-tip cells of onion seedlings after irradiation as dry seeds (vol 43, pg 397, 2000)
WY Zhang, S Endo, M Ishikawa, H Ikeda, M Hoshi, JOURNAL OF RADIATION RESEARCH, 44, 1, 81, 81, Mar. 2003
English, Others - MOTIVATION STYLES TO SPEAK OUT, DECISION RULES, AND GROUP SIZE AS DETERMINANTS OF DECISION MAKING : SIMULATION OF MEETINGS
ADACHI Nireka, ISHIKAWA Masayori, OKAMOTO Koichi E, SOCIOTECHNICA, 1, 0, 278, 287, 2003
In Japanese society corporate scandals, such as systematic violation, were found out one after another, and they have made profound impact on the society for these years. Most of all, the fact that acts clearly regarded as illegal were accepted in such corporation increased public distrust of it. Among various factors which lead to systematic violation, we consider decision procedures as one of the most important factors. Since violations were accepted through formal meetings at JCO which caused criticality accident, it must be paid to attention that which procedure is taken in group decisi..., Sociotechnology Research Network - ホウ素中性子捕捉療法における光ファイバーを用いた熱中性子束モニターの開発 (第37回京都大学原子炉実験所学術講演会)
石川 正純, 宇根崎 博信, 古林 徹, 京都大学原子炉実験所学術講演会報文集, 37, 0, 231, 234, Jan. 2003
京都大学原子炉実験所, Japanese - 硼素含有壁を持つ組織等価比例計数管を用いた重水場の線質評価 (第37回京都大学原子炉実験所学術講演会)
鬼塚 昌彦, 遠藤 暁, 石川 正純, 京都大学原子炉実験所学術講演会報文集, 37, 0, 241, 245, Jan. 2003
京都大学原子炉実験所, Japanese - Thermal Neutron Flux Evaluation for Boron Neutron Capture Therapy Using Scintillatior with Optical Fiber Detector
ISHIKAWA MASAYORI, ONO KOJI, SAKURAI YOSHINORI, KOSAKO TOSHISO, 第12回東京大学原子力研究総合センターシンポジウム 平成15年, 181-184, 2003
Japanese - ホウ素中性子捕捉療法における光ファイバーを用いた熱中性子束モニターの開発
石川正純, 宇根崎博信, 古林徹, 桜井良憲, 田中憲一, 遠藤暁, 星正治, 京都大学原子炉実験所学術講演会報文集, 37th, 231-234, 234, Jan. 2003
京都大学原子炉実験所, Japanese - ほう素含有壁を持つ組織等価比例計数管を用いた重水場の線質評価
鬼塚昌彦, 遠藤暁, 石川正純, 桜井良憲, 古林徹, 山口寛, 前田直子, 早淵尚文, 高辻俊宏, 京都大学原子炉実験所学術講演会報文集, 37th, 241-245, 245, Jan. 2003
京都大学原子炉実験所, Japanese - 広大原医研年報第43号,2002 I 研究概況 附属国際放射線情報センター研究概況
早川式彦, 星正治, ズマジーロフ ザクシバ, オルロフ マーク, カミドワ ローラ, 高田純, 石川正純, 川野徳幸, 新田由美子, 広島大学原爆放射線医科学研究所年報, 43, 115-139,329-351, Dec. 2002
Japanese - Relative biological effectiveness of fission neutrons for producing micronuclei in the root-tip cells of onion seedlings after irradiation as dry seeds
WY Zhang, S Endo, M Ishikawa, H Ikeda, M Hoshi, JOURNAL OF RADIATION RESEARCH, 43, 4, 397, 403, Dec. 2002
English - 加速器を用いた7Li(p,n)7Beしきい値近傍反応中性子の直接利用による術中照射BNCTの可能性
田中憲一, 古林徹, 桜井良憲, 中川義信, 石川正純, 星正治, 理工学における同位元素・放射線研究発表会要旨集, 39th, 59, 20 Jun. 2002
Japanese - An estimation of RBE for therapeutic carbon beam at HIMAC using microdosimetric technique
ONIZUKA Y, ENDO S, TAKADA M, ISHIKAWA M, HOSHI M, UEHARA S, MATSUFUJI N, KANAI T, YAMAGUCHI H, MAEDA N, HAYABUCHI N, Japanese journal of medical physics, 22, 0, 55, 58, 04 Apr. 2002
日本医学物理学会, Japanese - The investigation of the feasibility of intra-operative BNCT using the near-threshold^7Li(p, n)^7Be direct neutrons
TANAKA Kenichi, KOBAYASHI Tooru, SAKURAI Yoshinori, NAKAGAWA Yoshinobu, ISHIKAWA Masayori, HOSHI Masaharu, Japanese journal of medical physics, 22, 0, 218, 221, 04 Apr. 2002
日本医学物理学会, Japanese - Neural networks for the neutron spectrum determination based on the foil activation method
S Endo, E Yoshida, Y Yoshitake, WY Zhang, K Fujikawa, T Itoh, M Ishikawa, M Hoshi, K Shizuma, JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS, 41, 4A, 2191, 2194, Apr. 2002
English - Neural networks for the neutron spectrum determination based on the foil activation method
S Endo, E Yoshida, Y Yoshitake, WY Zhang, K Fujikawa, T Itoh, M Ishikawa, M Hoshi, K Shizuma, JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS, 41, 4A, 2191, 2194, Apr. 2002
English - 中性子捕捉療法におけるしきい値近傍の7Li(p,n)7Be反応及び7Li(p,p′γ)7Li反応の模擬計算の有効性の確認
田中憲一, 古林徹, 桜井良憲, 中川義信, 石川正純, 星正治, 日本原子力学会春の年会要旨集, 40th, 191, 05 Mar. 2002
Japanese - Microdosimetry of epithermal neutron field at the Kyoto University reactor
Y Onizuka, S Endo, M Ishikawa, M Hoshi, M Takada, T Kobayashi, Y Sakurai, H Utsumi, S Uehara, N Hayabuchi, N Maeda, T Takatuji, K Fujika, RADIATION PROTECTION DOSIMETRY, 99, 1-4, 383, 385, 2002
English - The benchmark of the simulation calculation for near-threshold 7Li(p, n)7be reaction in neutron capture therapy
Kenichi Tanaka, Tooru Kobayasm, Yoshinori Sakurai, Yoshinobu Nakagawa, Masayori Ishikawa, Masaharu Hosm, Journal of Nuclear Science and Technology, 39, 1290, 1293, 2002
English - A Monte Carlo track structure code for low energy protons
S. Endo, E. Yoshida, H. Nikjoo, S. Uehara, M. Hoshi, M. Ishikawa, K. Shizuma, Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 194, 2, 123, 131, 2002
English - Characterisation of an ultra-miniature counter for microdosimetric measurements in a therapeutic 400 MeV/A carbon beam
S Endo, M Takada, M Ishikawa, M Hoshi, S Uehara, H Yamaguchi, T Kanai, N Matsufuji, K Shizuma, Y Onizuka, RADIATION PROTECTION DOSIMETRY, 99, 1-4, 421, 424, 2002
English - しきい値近傍の7Li(p,n)7Be反応中性子を直接利用した術中照射BNCTの検討
田中憲一, 古林徹, 桜井良憲, 中川義信, 石川正純, 星正治, 京都大学原子炉実験所学術講演会報文集, 36th, 140-145, 145, Jan. 2002
京都大学原子炉実験所, Japanese - 放射線先端医学実験施設放射線実験系研究概況
渡辺敦光, 石川正純, 田内広, 小松賢志, 竹岡清二, 北川和英, 管慎治, 両角真里子, 広島大学原爆放射能医学研究所年報, 42, 139-140,391-393, Dec. 2001
Japanese - Optimization technique for a prompt gamma-ray SPECT collimator system
M Ishikawa, T Kobayashi, Y Sakurai, K Kanda, JOURNAL OF RADIATION RESEARCH, 42, 4, 387, 400, Dec. 2001
English - Calculation of Neutron-induced Activity Based on Updated Leakage Spectrum from Little Boy
IMANAKA Tetsuji, HOSHI Masaharu, ISHIKAWA Masayori, TAKADA Jun, SHIZUMA Kiyoshi, ENDO Satoru, IWATANI Kazuo, OKA Takamitsu, FUJITA Shoichiro, HASAI Hiromi, Journal of radiation research, 42, 4, 473, 473, Dec. 2001
The Japan Radiation Research Society, English - Directional distribution of radiation around an accident at a uranium fuel factory in Tokai-mura, 1999
J Takada, S Suga, K Kitagawa, M Ishikawa, S Takeoka, M Hoshi, H Watanabe, A Ito, N Hayakawa, JOURNAL OF RADIATION RESEARCH, 42, 1, 47, 55, Mar. 2001
English - A statistical estimation method for counting of the prompt gamma-rays from B-10(n,alpha gamma)Li-7 reaction by analyzing the energy spectrum
M Ishikawa, T Kobayashi, K Kanda, NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 453, 3, 614, 620, Oct. 2000
English - 東海村JCO臨界事故350m避難区域住民の被曝線量
高田純, 菅慎治, 北川和英, 石川正純, 星正治, 日本放射線影響学会大会講演要旨集, 43rd, 56, 21 Aug. 2000
Japanese - 砂糖を用いたESR法によるJCO事故の被ばく線量調査結果
白石久二雄, 木村真三, 米原英典, 高田純, 石川正純, 五十嵐康人, 青山道夫, 中島敏行, 小村和久, 日本放射線影響学会大会講演要旨集, 43rd, 104, 21 Aug. 2000
Japanese - JCO臨界事故における漏えい中性子の方向分布
高田純, 菅慎治, 北川和英, 石川正純, 星正治, 理工学における同位元素研究発表会要旨集, 37th, 196-199, 20 Jun. 2000
Japanese - 中性子低エネルギー領域におけるTE‐TE電離箱の中性子感度の計算
遠藤暁, 石川正純, 星正治, 静間清, 医学物理, 20, Supplement 2, 34-35, 06 Apr. 2000
Japanese - Genetic Effects of Accelerated Heavy Ions in Drosophila Somatic Mutations. Genetical Synergism of Gravitational Factor and Radiation.
YOSHIKAWA ISAO, TAKATSUJI TOSHIHIRO, HOSHI MASAHARU, TAKADA JUN, ENDO SATORU, ISHIKAWA MASAZUMI, NIRS−M (Natl Inst Radiol Sci), 139, 159-162, Apr. 2000
Japanese - The JCO criticality accident at Tokai-mura, Japan: an overview of the sampling campaign and preliminary results
K Komura, M Yamamoto, T Muroyama, Y Murata, T Nakanishi, M Hoshi, J Takada, M Ishikawa, S Takeoka, K Kitagawa, S Suga, S Endo, N Tosaki, T Mitsugashira, M Hara, T Hashimoto, M Takano, Y Yanagawa, T Tsuboi, M Ichimasa, Y Ichimasa, H Imura, E Sasajima, R Seki, Y Saito, M Kondo, S Kojima, Y Muramatsu, S Yoshida, S Shibata, H Yonehara, Y Watanabe, S Kimura, K Shiraishi, T Ban-nai, SK Sahoo, Y Igarashi, M Aoyama, K Hirose, T Uehiro, T Doi, A Tanaka, T Matsuzawa, JOURNAL OF ENVIRONMENTAL RADIOACTIVITY, 50, 1-2, 3, 14, 2000
English - Radioactivity of Cr-51 in stainless steel collected from residences in the JCO neighborhood
S Endo, N Tosaki, K Shizuma, M Ishikawa, J Takada, S Suga, K Kitagawa, M Hoshi, JOURNAL OF ENVIRONMENTAL RADIOACTIVITY, 50, 1-2, 83, 88, 2000
English - A noninvasive dose estimation system for clinical BNCT based on PG-SPECT - Conceptual study and fundamental experiments using HPGe and CdTE semiconductor detectors
Tooru Kobayashi, Yoshinori Sakurai, Masayori Ishikawa, Medical Physics, 27, 9, 2124, 2132, 2000
John Wiley and Sons Ltd, English - Doses to 350m zone-residents around Tokaimura JCO criticality accident site :
Takada J., Suga S., Kitagawa K., Ishikawa M., Hoshi M., Journal of radiation research, 41, 4, 378, 378, 2000
the Japan Radiation Research Society, English - Survey of external dose around JCO facility using sugars and ESR method :
SHIRAISHI Kunio, KIMURA Shinzo, YONEHARA Hidenori, TAKADA Jun, ISHIKAWA Masayori, IGARASHI Yasuhito, Aoyama Michio, NAKAJIMA Toshiyuki, KOMURA Kazuhisa, Journal of radiation research, 41, 4, 491, 491, 2000
the Japan Radiation Research Society, English - The Investigation of the Under-surgery Irradiation of NCT using Near-threshold 7Li(p,n)7Be Neutrons
K.Tanaka, T.Kobayashi, Y.Sakurai, Y.Nakagawa, M.Ishikawa, S.Endo, M.Hoshi, 9th International Symposium on Neutron Capture Therapy\n, 49, 50, 2000
English - Prompt Gamma Ray Measurement in the KUR Irradiation Room by Cd-Zn-Te Semiconductor Detector for PG-SPECT
T.Kobayashi, M.Ishikawa, Y.Sakurai, 9th International Symposium on Neutron Capture Therapy\n, 77, 78, 2000
English - Preliminary Study on 2-dimensional Distributions of 10B Reaction Rate in a Water Phantom with Boron-doped CR-39 for 7Li(p,n)7Be Neutrons by 1.95 MeV Protons
Y.Hasegawa, K.Tanaka, T.Kobayashi, Y.Sakurai, M.Ishikawa, M.Hoshi, T.Tsuruta, 9th International Symposium on Neutron Capture Therapy\n, 279, 280, 2000
English - Microdosimetry of Epithermal Neutron Beam
Y.Onizuka, S.Uehara, S.Endo, M.Ishikawa, J.Takada, M.Hoshi, Y.Sakurai, T.Kobayashi, H.Ustumi, N.Hayabuchi, T.Takatsuji, H.Yamaguchi, M.Takada, K.Fujikawa, N.Maeda, 9th International Symposium on Neutron Capture Therapy\n, 265, 266, 2000
English - Eexamination of accelerator-based neutron irradiation system in the neutron capture therapy and PG-SPECT on-line dosimetry and evaluation system.
KOBAYASHI TOORU, SAKURAI YOSHINORI, TANAKA KEN'ICHI, ISHIKAWA MASAZUMI, 京都大学原子炉実験所学術講演会報文集, 34th, 30-35, Jan. 2000
Japanese - A crack model of the Hiroshima atomic bomb: Explanation of the contradiction of "Dosimetry system 1986"
M Hoshi, S Endo, J Takada, M Ishikawa, Y Nitta, K Iwatani, T Oka, S Fujita, K Shizuma, H Hasai, JOURNAL OF RADIATION RESEARCH, 40, Suppl., 145, 154, Dec. 1999
English - Chemical Separation for 63Ni Measurement
SHIBATA Seiichi, TAKAMIYA Koichi, NAKAGAWA Takuji, HOSOYA Yuichi, SHINOHARA Atsushi, SHIBATA Tokushi, ITOH Yutaka, IMAMURA Mineo, NOGAWA Norio, SHIZUMA Kiyoshi, Journal of radiation research, 40, 4, 364, 364, Dec. 1999
The Japan Radiation Research Society, English - Efficient evaluating for prompt gamma-ray from 10B(n,.ALPHA..GAMMA.)7Li reaction at low counting rate.
ISHIKAWA MASAYORI, KOBAYASHI TOORU, KANDA KEIJI, 日本原子力学会春の年会要旨集, 36th, 135, Mar. 1998
Japanese - Silicide coating on iron from molten salts bath by electroless technique.
NISHIHATA TOSHINOBU, ISHIKAWA MASAZUMI, SUZUKI RYOSUKE, ONO KATSUTOSHI, 材料とプロセス, 9, 3, 468, Mar. 1996
Japanese - Measurement of residual radioactivity ^<60>Co and ^<63>Ni for the evaluation of atomic-bomb neutron (II)
SHIZUMA Kiyoshi, IWATANI Kazuo, HASAI Hiromi, OKA Takamitsu, HOSHI Masaharu, IMANAKA Tetsuji, SHIBATA Tokushi, SHIBATA Seiichi, IMAMURA Mineo, Journal of radiation research, 36, 4, 320, 320, Dec. 1995, [Peer-reviewed]
The Japan Radiation Research Society, English - Measurement of residual radioactivity ^<60>Co and ^<63>Ni for the evaluation of atomic - bomb neutrons
SHIZUMA Kiyoshi, IWATANI Kazuo, HASAI Hiromi, OKA Takamitsu, HOSHI Masahuru, SHIBATA Tokushi, SHIBATA Seiichi, IMAMURA Mineo, Journal of radiation research, 35, 4, 332, 332, Dec. 1994
The Japan Radiation Research Society, English - A METHOD TO ESTIMATE THE FAST-NEUTRON FLUENCE FOR THE HIROSHIMA ATOMIC-BOMB
T SHIBATA, M IAMMURA, S SHIBATA, Y UWAMINO, T OHKUBO, S SATOH, N NOGAWA, H HASAI, K SHIZUMA, K IWATANI, M HOSHI, T OKA, JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN, 63, 10, 3546, 3547, Oct. 1994
English, Report scientific journal
Books and other publications
- 会議の科学―健全な決裁のための社会技術 (組織の社会技術2)
岡本 浩一, 石川 正純, 足立 にれか
新曜社, 16 Aug. 2006, 4788510065, 263, Japanese, [Joint work]
- リスク・マネジメントの心理学 : 事故・事件から学ぶ
岡本, 浩一, 今野, 裕之, 堀, 洋元, 大野, 晋, 王, 晋民, 石川, 正純, 足立, にれか, 鎌田, 晶子, 上瀬, 由美子, 岡部, 康成, 下村, 英雄, 宮本, 聡介
新曜社, Jun. 2003, 9784788508606, xiv, 320, 23p, Japanese
Research Themes
- 複合現実を活用した光免疫療法におけるガイドカテーテル穿刺支援システムの開発
科学研究費助成事業
01 Apr. 2024 - 31 Mar. 2027
足利 雄一, 鈴木 崇祥, 石川 正純, 若林 侑輝
日本学術振興会, 基盤研究(C), 北海道大学, 24K13124 - Investigation of radiation response mechanism of BaTiO3 dielectric and its application to ultra-high density multidimensional dosimeter
Grants-in-Aid for Scientific Research
01 Apr. 2023 - 31 Mar. 2026
石川 正純
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 23H02846 - Development of integrated dose evaluation system in accelerator-based BNCT treatment
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
01 Apr. 2019 - 31 Mar. 2023
石川 正純, 小川原 亮
加速器BNCTでは、熱外中性子を主たる成分として照射することから、熱外中性子照射量をモニタできる検出器の開発が望まれている。そこで本研究では、熱中性子照射量をリアルタイムで測定可能なSOF検出器を改良し、異なる中性子増感物質を含むシンチレータを組み合わせることにより、熱中性子量、熱外中性子量、ガンマ線量を同時に評価することが可能な新たなSOF検出器を開発する。
マルチコア型SOF検出器に適した中性子増感物質および化合物を選定し、有効な発光量を得るためにnmオーダーまで微細化した粉末を用いたプローブを作成したが、期待した信号量（発光量）が得られなかった。そこで、プラスチックシンチレータ発光の時間変化が荷電粒子の種類に応じて変化することを利用し、PQD（Peak to charge discrimination）法を用いて対象となる反応のみを抽出する方法を試みた。PQDヒストグラムを作成したところ、成分が分かれることは確認されたが、シミュレーションによる計算とは十分には一致しない結果となった。一方、BNCTでは患部におけるホウ素（B-10）濃度も治療効果に大きく影響する。現在、患部への集積度を18F-BPA PET画像から評価しているが、血中ホウ素濃度との相関関係は患者に依存する。そこで本研究では、18F-BPA PET撮像中に同時に血中ホウ素濃度を測定するための腕部装着可能な小型PET装置を開発し、血中ホウ素濃度とPET画像による評価の相関関係を患者個別に構築できるシステムを開発を目指している。本研究で開発する腕部装着型PET装置のためのDOI検出器開発では、最低32チャンネルの高速信号処理回路が必要となることから、16チャンネル分の汎用高速計測ボードを購入し、アナログフロントエンド回路の開発を行った。
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 19H03594 - Fundamental study for real-time eye lens exposure measurement system
Grants-in-Aid for Scientific Research
01 Apr. 2017 - 31 Mar. 2023
Sakuhara Yusuke
In this study, we used a compact, portable instrument that can measure radiation dose in real time by attaching a scintillator probe to any position of protection glasses, and the possibility of real-time measurement of operators' radiation exposure during procedures and treatments under X-ray fluoroscopy was demonstrated. However, the current problem is that the instrument itself needs to be shielded.
It was found that a suitable dosimeter position for measuring lens exposure is on the back side of the lens on the X-ray source side. On the other hand, the gap between the glasses and the eye lens and the shape of the glasses have an influence on exposure from the unshielded area, so this result is limited to cases where the glasses with lateral shielding are properly put on.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 17K10426 - Establishment of novel dose distribution analysis method considering dose gradient
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
01 Apr. 2015 - 31 Mar. 2018
Ishikawa Masayori, SUZUKI Ryusuke, HASHIMOTO Masatoshi
The purpose of this study is to establish the Gradient method which is a new analysis method considering the dose gradient as a dose distribution evaluation method using film in radiation therapy. Generally, since radiation measurement follows Poisson statistics, we proposed a statistical based judgment criterion. In order to make statistical evaluation possible, we developed a method to evaluate uncertainty caused by measurement and misalignment, and verified by actual measurement at multiple facilities.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 15H04767 - Functional evaluation in animal models of radiosurgical brain lesions
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
01 Apr. 2014 - 31 Mar. 2017
Tanaka Masaki, KUNIMATU JUN, TAKEYA RYUJI, ISHIKAWA MASAYORI, MIYAMOTO NAOKI
Experimental technique to produce focal brain lesions may provide opportunities for future research exploring mechanisms of brain function and recovery from injury. As a candidate method, we evaluated the radiosurgical technique. We also tried to develop behavioral and electrophysiological techniques to examine subcortical brain functions, and explored new methods to generate focal brain lesions. We evaluated the oculomotor behavior in monkeys up to 8 months following irradiation to the frontal eye field. In addition, we have developed several behavioral tasks and a method to record cortical potentials through epi-dural electrodes, both of which are usable to detect subcortical dysfunction. Further, we performed a feasible study of chemogenetic application to monkeys by injecting a viral vector into the cerebellum. Through these studies, we could obtain valuable information for future studies.
Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 26560454 - Development of a target system and neutron dosimetry for the accelerator boron neutron capture therapy (BNCT)
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
01 Apr. 2012 - 31 Mar. 2015
HOSHI Masaharu, ONIDUKA Yoshihiko, ENDO Satoru, ISHIKAWA Masayori, SATO Hitoshi, OHTAKI Megu, HAMANO Tsuyoshi, SUDA Mitsuru, KAMADA So, TAKADA Masashi, TANAKA Kenichi, YAMAKAWA Kyohei, HIGASHIMATA Atsushi, ARAI Seiji, ZHUMADILOV Kassym
In the radiation therapy, X rays, gamma rays, protons and so on have been used. In this study we use neutrons. This method is called Boron Neutron Capture Therapy (BNCT). Boron is absorbed in cancer and expose neutrons. Then the boron emits alpha rays of which range is about the size of cancer cells. So each cancer cell will be killed by this method. The traditional way of radiation therapy is as like to say "burn cancer mass". This method is especially useful for the brain tumor which invade in the healthy cells. Before we used reactor neutrons, however in this study we developed a target system and real time neutron measurement system for the proton accelerator, which will be easily installed in each hospital.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hiroshima University, 24310044 - Development of a research technique to create animal model of brain lesions using therapeutic linear accelerator
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
01 Apr. 2012 - 31 Mar. 2014
TANAKA Masaki, ISHIKAWA Masayori, KUNIMATU Jun, MIYAMOTO Naoki
We developed a research technique to create animal model of brain lesions using the therapeutic linear accelerator. A total of four irradiations (130-150 Gy) were performed on the right frontal eye field of three Japanese monkeys. During a few weeks following irradiation, brain edema was evident in MRI and the performance of oculomotor tasks was declined; however, it recovered thereafter. For one monkey that was followed up about 8 months, the behavioral deficits reappeared in the 4th month and gradually progressed. Postmortem histological examination in two animals revealed large necrosis in the white matter and surrounding hemorrhage, but the cortical gray matter retained layers. This technique can be applied to deep brain structures in the future study. We now plan to use lower doses and will follow up longer interval.
Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 24650206 - Development of novel in-vivo dosimeter using implantable fiducial coil marker
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
2012 - 2012
ISHIKAWA Masayori
The purpose of this study is developing implantable fiducial marker which has dosimeter function for cummlative absorbed dose with wireless measurement. By using capacitance change due to radiation irradiation, irradiated dose to marker can be measured by measuring resonant frequency of coil-capacitor system. A network analyzer-based measurement was performed to measure capacitance through an antenna coil, we succeeded in precise measurement for the capacitance ranging from 1 pF to 100 nF. Additionally, we conclude that wireless measurement of 20 cm distance is possible from simulation results.
Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, Principal investigator, Competitive research funding, 24659552 - Development of radiation detectors based on crystal growth of CVD single diamond combined with a lift-off method
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
2010 - 2012
KANEKO Junichi, FUJITA Fumiyuki, SHIKATA Shinichi, SASAO Mamiko, SATO Satoshi, ISOBE Mitsutaka, NAKAI Mitsuo, ASANO Yoshihiro, ISHIKAWA Masazumi
Growth condition of CVD diamond single crystals were optimized. Radiation detectors were fabricated form the grown CVD diamonds; then induced charge collection distribution measurement for the detectors were carried out by use of alpha particles. Charge collection efficiency of 100 % and 97 %, μτ values of 1×10-4 and 9.6×10-6 cm2/V for holes and electrons were achieved by one of the best detectors. In addition, energy resolution of 3.5 % at a peak caused by the 12C(n, alpha)9Be reactions were obtained in response function measurement for 14 MeV neutrons. Fast time resolution of 350 ps was also achieved for 8 GeV electron beams.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 22360395 - Research for Real-time Tracking Medical Science
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
2009 - 2012
SHIRATO Hiroki, HONMA Sato, TAMAKI Nagara, KUGE Yuji, MIZUTA Masahiro, DATE Hiroyuki, TANAKA Masaki, HAGA Hisashi, NISHIOKA Takeshi, KATO Motothugu, CHAMOTO Kenji, OIZUMI Satoshi, MATSUNAGA Naofumi, OKIMOTO Tomoaki, HAYAKAWA Kazushige, NISHIO Teiji, TADANO Shigeru, ISHIKAWA Masayori, ONODERA Yasuhito, SHIBUYA Keiko, HAMADA Toshiyuki, ONIMARU Rikiya, SHIMIZU Shinichi, TSUCHIYA Kazuhiko, KATOH Norio, KINOSHITA Rumiko, INOUE Tetsuya, ONODERA Syunsuke, TAKAO Seishin, KAGA Kichizo, TERAE Satoshi, ONODERA Yuya, SAKUHARA Yusuke, MANABE Noriko, ABO Daisuke, KATO Fumi, KHIN KHIN Tha, NAM Jin-min, SABE Hisataka, INUBUSHI Masayuki, SHINAGAWA Naofumi, KENNETH Sutherland
Up to now, in the field of basic medicine from micro-level to animal level, to track and quantify the three-dimensional spatial information along the time axis in real-time has not caught up with the accuracy in the field of clinical medicine. By handing big data of “motion in life, a new idea of real-time radiotherapy and a new precise four-dimensional computed tomography has been developed based on the data of actual tumor motion in the human body.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Hokkaido University, Coinvestigator not use grants, Competitive research funding, 21249065 - Develo pments of the target cooling and dosimetry systems for the use of the accelerator boron neutron capture therapy
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
2009 - 2011
MASAHARU Hoshi, ZHUMADILOV Kassym, ENDO Satoru, ISHIKAWA Masayori, TAKADA Masashi, SATO Hitoshi
New target system for the accelerator boron neutron capture therapy by using water cooling system was developed. The target was tested 6 times using the 3MeV proton beam of the accelerator in National Institute for Radiological Sciences with the same power per unit area and was verified to have enough ability to keep the temperature below about 100 degrees. From these results we can manufacture an actual target system. For the dosimetry system we used new plastic including boron and made verified the possibility of the new chamber system to measure necessary neutrons for boron neutron capture therapy system.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hiroshima University, Coinvestigator not use grants, Competitive research funding, 21310039 - Absorbed dose measurement using implantable dosimeter during radiotherapy and prevention of radiation damage
Grants-in-Aid for Scientific Research(若手研究(A))
2007 - 2009
Masayori ISHIKAWA
We published a paper regarding basic concept of SOF dosimeter (Scintillator with optical Fiber Dosimeter) as a function of dosimeter. SOF dosimeter measurements were performed for 11 patients who had a high dose rate brachytherapy undergoing to prostate cancer. Measurements were performed at the highest dose point inside the urethra predicted by treatment planning software, the dose given during the treatment was confirmed by real-time monitoring. To adapt high energy X ray or gamma ray measurement, dichroic mirror type SOF dosimeter was developed. We optimized the threshold wavelength of t...
Ministry of Education, Culture, Sports, Science and Technology, 若手研究(A), 北海道大学, Principal investigator, Competitive research funding, 19689025 - In vivo imaging of clock gene expression in conscious animals
Grants-in-Aid for Scientific Research(基盤研究(B))
2007 - 2009
Sato HONMA, 早坂 直人, 仲村 朋子, Naoto HAYASAKA, Toshiyuki HAMADA, Masayori ISHIKAWA, Hidehiro KUBOTA, Masahiro SHIMOGAWARA, Toshiteru ENOMOTO
本研究は、in vivoで、無麻酔・無拘束動物から時計遺伝子発現リズムを計測し、視交叉上核(SCN)に局在する哺乳類の中枢時計の行動リズム制御メカニズムを明らかにすることを目的として行った。時計遺伝子Per1プロモータ支配下に発光酵素ルシフェラーゼを発現するPer1-lucマウスを用い、自発行動量と光ファイバーによるSCNの時計遺伝子発現を同時計系を構築し、1分毎の連続測定を行った。その結果、SCN、嗅球いずれからも、安定したPer1-lucのフリーランリズムが計測された。さらに、光同調や位相反応を示すことから、内因性振動を反映していることが確認できた。
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 北海道大学, Coinvestigator not use grants, Competitive research funding, 19390057 - Interactive Radiotherapy
Grants-in-Aid for Scientific Research(基盤研究(A))
2006 - 2008
Hiroki SHIRATO, Sato HONMA, Nagara TAMAKI, Yoshiaki KIYANAGI, Masanori HATAKEYAMA, Junichi KANEKO, Yuji KUGE, Hiroyuki DATE, Masahiro MIZUTA, Masayuki INUBUSHI, Shigeru TADANO, Mamoru TAMURA, Kazushige HAYAKAWA, Naofumi MATSUNAGA, Masayori ISHIKAWA, Hidefumi AOYAMA, Yusuke SAKUHARA, Rikiya ONIMARU, Daisuke ABO, Masataka OITA, Tamotsu KAMISHIMA, Satoshi TERAE, Kohsuke KUDO, Yuya ONODERA, Tokuhiko OMATSU, Shinichi SHIMIZU, Takashi NISHIMURA, Ryusuke SUZUKI, Bengua GERARD
いままでの先端放射線医療に欠けていた医療機器と患者のinteractionを取り入れた放射線治療を可能にする。臓器の動き・腫瘍の照射による縮小・免疫反応などは、線量と時間に関して非線形であり、システムとしての癌・臓器の反応という概念を加えることが必要であることが示唆された。生体の相互作用を追求していく過程で、動体追跡技術は先端医療のみならず、基礎生命科学でも重要な役割を果たすことがわかった。
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(A), 北海道大学, Coinvestigator not use grants, Competitive research funding, 18209039 - ホウ素中性子捕捉療法における吸収線量制御の高度化に関する研究
科学研究費補助金(若手研究(A))
2004 - 2006
石川 正純
2006年度現在、国内で唯一ホウ素中性子捕捉療法が行われている日本原子力研究開発機構にリアルタイム熱中性子モニタ(SOF検出器)を配備した。同時に複数箇所で測定が行えるようにするために、測定回路系の仕様変更を行い、同時に8箇所の熱中性子束測定が行えるシステムを完成させた。その結果、現在のところ、2箇所での同時測定を行い、1箇所は患者の動き等の影響を受けないコリメータ内側に配置、もう一箇所は患者表面へ貼り付けて測定を行うことが可能となった。臨床において実際の症例に対して計30回以上のリアルタイム熱中性子束計測を行い、従来の熱中性子束評価法と比較してほぼ同等の計測値が取得でき、SOF検出器の有効性を確認した。また、治療計画装置JCDSで計算された線量分布・熱中性子束分布に、SOF検出器によるリアルタイム熱中性子束を反映させることによって、リアルタイムでの各種線量分布、中性子束分布を3次元で確認することが出来るソフトウェアを開発した。開発したソフトウェアでは、患者の体輪郭構造が分かるように、CT画像データ上に線量分布・中性子束分布を重ね合わせて表示できるように工夫を施した。これらの分布は、SOF検出器による測定値に連動して、1秒単位で更新されるため、リアルタイムでの線量分布評価が可能となった。したがって、患者のあらゆる箇所における線量を照射中に確認することが出来るため、過剰線量およ...
文部科学省, 若手研究(A), 東京大学->北海道大学, Principal investigator, Competitive research funding, 16689022 - Two dimensional element mapping technique SPECT-PIXE using extracted proton beam
Grants-in-Aid for Scientific Research(基盤研究(B))
2002 - 2005
Satoru ENDO, 小島 康明, 星 正治, 静間 清, 石川 正純
We want to develop a new particle induced X-ray emission measurement of the so-call SPECT-PIXE which has a possibility of 2 dimensional element mapping without the microbeamline. To do this, we try to test that 1) possibility of PIXE using CdTedetector, 2) PIXE using extracted proton beam to air, and also we perform simulations using MCNP particle transport code to design the pin-hole collimator for the put-hole PIXE.We made the above mentioned tests ;1) Simulation which the particle induced and emitted X-ray can be focus using pin-hole collimator had been confirmed.2) As a model device for...
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 広島大学, Coinvestigator not use grants, Competitive research funding, 14380254 - ホウ素中性子捕捉療法における新しい熱中性子フルーエンス測定法の開発
科学研究費補助金(若手研究(B))
2002 - 2003
石川 正純
本研究は、ホウ素中性子捕捉療法における治療中の熱中性子束をリアルタイムで測定するための検出器であるSOF検出器(Schintillator with Optical Fiber Detector)の改良を目的としている。(1)検出器システムの小型化: SOF検出器システムは光電子増倍管、波形整形増幅器、波高弁別器、計数器といった一般的な機器で構成されていることから、従来のCAMACやNIMのモジュールを使用せずに、市販のフォトンカウンティングユニットをシステムに取り込むことによって、安定かつ小型なシステムの構築に成功した。(2)検出プローブの改良:昨年度までは、シンチレーションファイバと光ファイバを光学セメントで接続させて検出プローブを構成していたが、光学セメントの放射線耐性が良好ではないことから、液状固化タイプのプラスチックシンチレータ使用を検討した。液状固化タイプの場合、様々な核種の中性子増感剤を混入または塗布することによって、種々の検出プローブ作製が可能となる。これまで、ホウ酸(B-10濃縮度99%)および弗化リチウム(Li-6濃縮度95%)による熱中性子の検出を試み、いずれも有効な測定が可能であることを確認した。また、中性子増感剤をシンチレータ表面に塗布した検出プローブは、シンチレータに混入した場合に比べてより大きな発光量が得られるが、作製したプローブ間のバラツキは、...
文部科学省, 若手研究(B), 広島大学->東京大学, Principal investigator, Competitive research funding, 14770455 - Development of an irradiation system of low-energy protons - To study the mechanism of the effects of neutrons for biological system-
Grants-in-Aid for Scientific Research(基盤研究(B))
2000 - 2002
Masaharu HOSHI, 高田 純, 遠藤 暁, 石川 正純, 岩本 英司, 新田 由美子
Relative biological effectiveness of neutrons is much higher than gamma- and beta-rays. As such cases of neutron exposure, we have experiences of atomic bomb survivors in Hiroshima and Nagasaki, and Tokai-mura accident. Neutrons when coming into human body recoil protons in hydrogen atoms which are included as a main component. Such recoil protons have charges. Therefore, as a consequence, they produce radicals, which induce DNA double strand breaks. The percentage of such proton recoils in neutron dose is 70-80% which depends on neutron energies. Almost all of such damages will be repaired...
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 広島大学, Coinvestigator not use grants, Competitive research funding, 12558061 - ホウ素中性子捕捉療法における治療中の吸収線量評価に関する研究
科学研究費補助金(奨励研究(A))
2000 - 2001
石川 正純
現在行われているホウ素中性子捕捉療法では、患者の血中ホウ素濃度と治療中に測定した中性子束密度を用い、事前に行った実験や計算をもとに吸収線量を推測している。我々の研究グループでは、治療中にリアルタイムで吸収線量を直接評価するために、PG-SPECT(Prompt Gamma-ray Single Photon Emission Computed Tomography)システムを提案し、その開発に取り組んでいる。PG-SPECTシステムは中性子線とγ線が多量に存在する治療照射場内に設置されるため、有効な測定を行うためには、コリメータシステムの最適化が必要である。そこで、コリメータのパラメータを決めるに当たって、測定の統計誤差を考慮した最適指数を考案し、パラメータの最適化を行った。この結果をもとに組立式タングステンコリメータを作成し、計算と実測との比較を行った。予算の都合上、コリメータの一部しか製作できなかったが、計算値と実測値はほぼ一致しており、最適指数による最適化が妥当であったことを確認した。また、PG-SPECTに装備する検出器として、(1)中性子のダメージ、(2)検出効率、(3)エネルギー分解能、(4)バックグラウンド除去、(5)冷却の5項目について検討を行った結果、BGOシンチレーション検出器が最も有利であるという結論に達した。そこで、サイズの異なる3種類のBGOシンチレ...
文部科学省, 奨励研究(A), 広島大学, Principal investigator, Competitive research funding, 12770491
Industrial Property Rights
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