Abe Takashige
| Faculty of Medicine Surgery Surgery | Professor |
| Hokkaido University Hospital | Professor |
Last Updated :2025/06/07
■Researcher basic information
Researchmap personal page
J-Global ID
Educational Organization
- Bachelor's degree program, Departments of Medicine, School of Medicine
- Master's degree program, Graduate School of Medicine
- Doctoral (PhD) degree program, Graduate School of Medicine
■Research activity information
Awards
Papers
- Urinary Dopamine Levels Can Predict the Avidity of Post-Therapy [131I]MIBG Scintigraphy in Unresectable or Metastatic Pheochromocytomas and Paragangliomas: A Preliminary Clinical Study
Junki Takenaka, Shiro Watanabe, Takashige Abe, Satoshi Takeuchi, Kenji Hirata, Rina Kimura, Hiroshi Ishii, Naoto Wakabayashi, Mungunkhuyag Majigsuren, Kohsuke Kudo
Pharmaceuticals, 18, 2, 165, 165, MDPI AG, 26 Jan. 2025
Scientific journal, Background/Objectives: Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that produce catecholamines. Unresectable or metastatic PPGLs are treated with [131I]metaiodobenzylguanidine (MIBG), but MIBG avidity is often heterogeneous. Identifying predictive factors for non-avid lesions on scintigraphy is clinically important. The primary objective of this study was to investigate the relationship between MIBG avidity and catecholamine secretion patterns in patients with unresectable or metastatic PPGLs. Methods: This retrospective study included 27 patients treated with [131I]MIBG for unresectable/metastatic PPGLs between 2001 and 2024. Patients received a single intravenous dose of [131I]MIBG (5.5–7.4 GBq), with post-therapy scintigraphy performed 3–7 days later. Non-avid lesions were assessed by imaging and confirmed using CT, MRI, and FDG-PET. Clinical factors, including age, sex, prior treatments, metastasis sites, and urine catecholamines, were evaluated using univariate logistic analysis. Predictive factors were assessed via receiver operating characteristic curves. Results: Non-avid lesions were found in nine patients (33.3%). These patients were younger (median age 38 vs. 62.5 years) and had higher urine dopamine levels (median 1510 vs. 779 μg/day) than those without non-avid lesions. Younger age (odds ratio: 0.892, p < 0.01) and higher urinary dopamine levels (odds ratio: 1.003, p < 0.01) were significantly associated with non-avid lesions. All patients > 45 years with urinary dopamine < 1190 μg/day had no non-avid lesions, whereas patients < 45 years with urinary dopamine > 1190 μg/day had non-avid lesions. Conclusions: Age and urinary dopamine levels may predict non-avid lesions in unresectable/metastatic PPGLs, aiding treatment decisions for [131I]MIBG therapy. This article is a revised and expanded version of a paper entitled “Urine dopamine level and age can predict non-avid lesion on scintigraphy after I-131 MIBG treatment for unresectable/metastatic PPGL”, which was presented at SNMMI 2024, Toronto, from 8 June to 11 June 2024. - 腎移植後に発症し,完全寛解を得た転移性精巣腫瘍の1例
東海林 旺次朗, 安部 崇重, 堀田 記世彦, 岩見 大基, 田邉 起, 大澤 崇宏, 松本 隆児, 広瀬 貴行, 菊地 央, 宮田 遥, 岩原 直也, 山田 修平, 篠原 信雄
泌尿器科紀要, 71, 1, 9, 15, 泌尿器科紀要刊行会, Jan. 2025
Japanese - [A Case of Metastatic Testicular Cancer after Kidney Transplantation in which Complete Remission was Achieved].
Ojiro Tokairin, Takashige Abe, Kiyohiko Hotta, Daiki Iwami, Tatsu Tanabe, Takahiro Osawa, Ryuji Matsumoto, Takayuki Hirose, Hiroshi Kikuchi, Haruka Miyata, Naoya Iwahara, Shuhei Yamada, Nobuo Shinohara
Hinyokika kiyo. Acta urologica Japonica, 71, 1, 9, 15, Jan. 2025, [Domestic magazines]
Japanese, Scientific journal, We report a case of testicular cancer after kidney transplantation in a 29-year-old man. Twenty-two years after the surgery, computed tomography (CT) showed a retroperitoneal mass 3 cm in diameter. Positron emission tomography (PET) -CT revealed high FDG uptake in both the right testis and retroperitoneal mass. Regarding serum tumor markers, α fetoprotein (AFP) was slightly elevated to 12.5 ng/ml. He underwent right radical orchiectomy, and pathological examination revealed pure seminoma. After surgery, the serum AFP level remained high (12. 9 ng/ml), and we initially considered this nonseminoma patient to have a good prognosis according to International Germ Cell Consensus Classification. During three cycles of a combination regimen including bleomycin, etoposide, and cisplatin (BEP), we performed adjustment of immunosuppressive therapy, treatment for Cytomegalovirus infection (valganciclovir hydrochloride), and that for other adverse events associated with systemic chemotherapy. The chemotherapy schedule was delayed, and bleomycin (third course, day 15) was skipped due to adverse effects. After 3 cycles of BEP, the retroperitoneal lymph node metastasis shrunk from 3.0 to 1.5 cm in diameter. In contrast to the good radiological response, the serum AFP level gradually increased during the treatment to 102.6 ng/ml. Therefore, we did not consider the AFP elevation to have derived from residual cancer, and decided to perform close follow-up. During the 3-year follow-up, AFP decreased to around 20 ng/ml, and PET-CT did not show any uptake in the retroperitoneal mass or other sites. - 【臨床腎・泌尿器癌(下)-基礎・臨床研究の進歩-】精巣癌の診断 腫瘍マーカー
安部 崇重, 菊地 央, 宮田 遥, 松本 隆児, 大澤 崇宏
日本臨床, 82, 増刊10 臨床腎・泌尿器癌(下), 166, 168, (株)日本臨床社, Dec. 2024
Japanese - ロボット手術・腹腔鏡手術に必要な泌尿器科解剖学 骨盤内リンパ節郭清のための解剖学
安部 崇重, 菊地 央, 宮田 遥, 松本 隆児, 大澤 崇宏
日本泌尿器内視鏡・ロボティクス学会総会, 38回, WS1, 3, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2024
Japanese - モーションキャプチャーを用いた熟練者の腹腔鏡手術鉗子動態の数値化・言語化の試み
安部 崇重, 今 雅史, 樋口 まどか, 岩原 直也, 堀田 記世彦, 菊地 央, 宮田 遥, 松本 隆児, 大澤 崇宏
日本泌尿器内視鏡・ロボティクス学会総会, 38回, AP4, 6, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2024
Japanese - 若手修練医の腹腔鏡手術トレーニングにおけるラーニングカーブの特徴
上條 千太, 堀田 記世彦, 樋口 まどか, 今 雅史, 松本 隆児, 大澤 崇宏, 安部 崇重
日本泌尿器内視鏡・ロボティクス学会総会, 38回, O8, 4, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2024
Japanese - T1b腎腫瘍に対するロボット支援腎部分切除術と開放腎部分切除の治療成績の比較検討
松本 隆児, 森口 卓哉, 永森 聖人, 宮田 遥, 大澤 崇宏, 安部 崇重
日本泌尿器内視鏡・ロボティクス学会総会, 38回, O32, 2, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2024
Japanese - Decision regret after curative treatment and its association with the decision-making process and quality of life for prostate cancer patients.
Miho Sato, Takahiro Osawa, Kentaro Nishioka, Tomohiko Miyazaki, Shuhei Takahashi, Takashi Mori, Takayuki Hashimoto, Haruka Miyata, Ryuji Matsumoto, Takashige Abe, Kazuki Ohashi, Sachiyo Murai, Yoichi M Ito, Nobuo Shinohara
International journal of urology : official journal of the Japanese Urological Association, 09 Oct. 2024, [International Magazine]
English, Scientific journal, OBJECTIVES: To determine how the treatment decision-making process and posttreatment health-related quality of life (HRQOL) are related to regret about treatment choice for prostate cancer patients in Japan. METHODS: We invited a total of 614 patients who were treated with radiation therapy (RT), radical prostatectomy (RP), or active surveillance/watchful waiting (AS/WW) from April 2007 to March 2021. Posttreatment regret was evaluated by the Decision Regret Scale. HRQOL was evaluated by the Expanded Prostate Cancer Index Composite and the 12-item Short Form Survey. The decision-making process was assessed by patient evaluation of the decision-making process. We compared the decision regret scale scores across treatment types, HRQOL, and decision-making processes. RESULTS: Data from 371 patients were analyzed (RT: 202, RP: 149, AS/WW: 20). The median length of time since treatment was 64 (IQR: 43-93) months. The decision regret scale scores were not significantly different among the treatment groups but were significantly greater (strong regret) in patients with poor urinary summary scores, bowel summary scores, and hormonal summary scores. The decision regret scale scores were significantly lower (less regret) for patients who reported being adequately informed at the time of the treatment decision and who had adequately communicated their questions and concerns to physicians than for patients who reported less adequate communication. This result was also observed among patients who reported low HRQOL scores. CONCLUSIONS: These findings underline the important influence of posttreatment HRQOL and decision-making as an interactive process between physicians and their patients on posttreatment regret in prostate cancer patients. - 【臨床腎・泌尿器癌(上)-基礎・臨床研究の進歩-】腎癌の治療とQOL
安部 崇重, 菊地 央, 宮田 遥, 松本 隆児, 大澤 崇宏
日本臨床, 82, 増刊8 臨床腎・泌尿器癌(上), 449, 454, (株)日本臨床社, Oct. 2024
Japanese - 前立腺がん患者における治療決定時の意思決定プロセスと治療後の後悔との関連
佐藤 三穂, 大澤 崇宏, 宮田 遥, 松本 隆児, 安部 崇重, 西岡 健太郎, 宮崎 智彦, 高橋 周平, 森 崇, 橋本 孝之, 大橋 和貴, 村井 祥代, 伊藤 陽一, 篠原 信雄
日本癌治療学会学術集会抄録集, 62回, YOA O22, 5, (一社)日本癌治療学会, Oct. 2024
Japanese - Validation and motion analyses of laparoscopic radical nephrectomy with Thiel-embalmed cadavers.
Lingbo Yan, Koki Ebina, Takashige Abe, Masafumi Kon, Madoka Higuchi, Kiyohiko Hotta, Jun Furumido, Naoya Iwahara, Shunsuke Komizunai, Teppei Tsujita, Kazuya Sase, Xiaoshuai Chen, Yo Kurashima, Hiroshi Kikuchi, Haruka Miyata, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Toshiaki Shichinohe, Soichi Murakami, Taku Senoo, Masahiko Watanabe, Atsushi Konno, Nobuo Shinohara
Current problems in surgery, 61, 10, 101559, 101559, Oct. 2024, [International Magazine]
English, Scientific journal, PURPOSE: Our aim was to develop practical training for laparoscopic surgery using Thielembalmed cadavers. Furthermore, in order to verbalize experts' motion characteristics and provide objective feedback to trainees, we initiated motion capture analyses of multiple surgical instruments simultaneously during the cadaveric trainings. In the present study, we report our preliminary results. METHODS: Participants voluntarily joined the present cadaveric simulation trainings, and performed laparoscopic radical nephrectomy. After the trainings, scores for tissue similarity (face validity) and impression of educational merit (content validity) were collected from participants based on a 5-point Likert scale (tissue similarity: 5: very similar, 3: average, 1: very different; educational merit: 5: very high, 3: average, 1: very low). In addition, after the additional IRB approval, we started motion capture (Mocap) analyses of 6 surgical instruments (scissors, vessel sealing system, grasping forceps, clip applier, right-angled forceps, and suction), using an infrared trinocular camera (120-Hz location record). Mocap-metrics were compared according to the previous surgical experiences (experts: ≧50 laparoscopic surgeries, intermediates: 10-49, novices: 0-9), using the Kruskal-Wallis test. RESULTS: A total of 9 experts, 19 intermediates, and 15 novices participated in the present study. In terms of face validity, the mean scores were higher than 3, other than for the Vena cava(mean score of 2.89). Participants agreed with the training value (usefulness for future skill improvement: mean score of 4.57). In terms of Mocap analysis, faster speed-related metrics (e.g., velocity, the distribution of tip velocity, acceleration, and jerk) in the scissors and vessel sealing system, a shorter path length of grasping forceps, and fewer dimensionless squared jerks, which indicated more purposeful motion of 4 surgical instruments (vessel sealing system, grasping forceps, clip applier and suction), were observed in the more experienced group. CONCLUSIONS: The Thiel-embalmed cadaver provides an excellent training opportunity for complex laparoscopic procedures with participants' high level of satisfaction, and may become a promising tool for a better objective understanding of surgical dexterity. In order to enrich formative feedback to trainees, we are now proceeding with Mocap analysis. - Surgical skill analysis focused on tissue traction in laparoscopic wet lab training.
Koki Ebina, Takashige Abe, Madoka Higuchi, Kiyohiko Hotta, Jun Furumido, Naoya Iwahara, Taku Senoo, Shunsuke Komizunai, Teppei Tsujita, Kazuya Sase, Xiaoshuai Chen, Yo Kurashima, Hiroshi Kikuchi, Haruka Miyata, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Atsushi Konno, Nobuo Shinohara
Surgery open science, 21, 7, 13, Sep. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: Tissue handling is one of the pivotal parts of surgical procedures. We aimed to elucidate the characteristics of experts' left-hand during laparoscopic tissue dissection. METHODS: Participants performed tissue dissection around the porcine aorta. The grasping force/point of the grasping forceps were measured using custom-made sensor forceps, and the forceps location was also recorded by motion capture system (Mocap). According to the global operative assessment of laparoscopic skills (GOALS), two experts scored the recorded movies, and based on the mean scores, participants were divided into three groups: novice (<10), intermediate (10≤ to <20), and expert (≤20). Force-based metrics were compared among the three groups using the Kruskal-Wallis test. Principal component analysis (PCA) using significant metrics was also performed. RESULTS: A total of 42 trainings were successfully recorded. The statistical test revealed that novices frequently regrasped a tissue (median total number of grasps, novices: 268.0 times, intermediates: 89.5, experts: 52.0, p < 0.0001), the traction angle became stable against the aorta (median weighted standard deviation of traction angle, novices: 30.74°, intermediates: 26.80, experts: 23.75, p = 0.0285), and the grasping point moved away from the aorta according to skill competency [median percentage of grasping force applied in close zone (0 to 2.0 cm from aorta), novices: 34.96 %, intermediates: 21.61 %, experts: 10.91 %, p = 0.0032]. PCA showed that the efficiency-related (total number of grasps) and effective tissue traction-related (weighted average grasping position in Y-axis and distribution of grasping area) metrics mainly contributed to the skill difference (proportion of variance of first principal component: 60.83 %). CONCLUSION: The present results revealed experts' left-hand characteristics, including correct tissue grasping, sufficient tissue traction from the aorta, and stable traction angle. Our next challenge is the provision of immediate and visual feedback onsite after the present wet-lab training, and shortening the learning curve of trainees. - Safety and efficacy of multiple-dose versus single-dose MIBG therapy in patients with refractory pheochromocytoma and paraganglioma: a single-center retrospective analysis.
Naoto Wakabayashi, Shiro Watanabe, Takashige Abe, Junki Takenaka, Kenji Hirata, Rina Kimura, Keita Sakamoto, Nobuo Shinohara, Kohsuke Kudo
Annals of nuclear medicine, 38, 7, 553, 562, Jul. 2024, [Domestic magazines]
English, Scientific journal, OBJECTIVE: To investigate the incidence of adverse events (AEs) following single and multiple administrations of I-131 metaiodobenzylguanidine (MIBG) therapy for inoperable pheochromocytomas and paragangliomas (PPGLs). METHODS: A single-center retrospective study was conducted on patients with inoperable PPGLs who underwent I-131 MIBG therapy between January 2000 and December 2020. A total of 28 patients with available electronic medical records were included. The treatment consisted of a single intravenous administration of 150 mCi (5.55 GBq) of I-131 MIBG. We evaluated the first MIBG treatment and repeated MIBG treatments performed within 200 days of the previous treatment. AEs for each treatment were evaluated using CTCAE version 4.0, and the statistical analysis was conducted at a significance level of p < 0.05. Objective response based on RECIST 1.1 criteria and biochemical response based on urinary catecholamines were assessed. RESULTS: The study included a total of 63 administrations, consisting of 28 single administrations (SAs), including the first administration for all 28 cases, and 35 multiple administrations (MAs), which included the second or later administrations. Hematological AEs were evaluable for 23 SAs and 29 MAs. Grade 3 or higher leukopenia occurred in 9.8% of all administrations, and Grade 3 or higher lymphopenia in 23.5%; both were manageable through observation. There were no significant differences in clinical AE Grades 1-2 (p = 0.32), hematological AE Grades 1-2 (p = 0.22), or hematological AE Grades 3-4 (p = 0.12) between MAs and SAs. Statistical analysis for each type of AE revealed significant increases in leukopenia (p < 0.01) and lymphopenia (p = 0.04). No significant difference in anemia, thrombocytopenia, or neutropenia was observed between MAs and SAs. There was no significant increase in the incidence rate of Grade 3 or higher hematological AEs for any of the parameters. The objective response rate was 0% for SAs and 36% for MAs. Biochemical response rates were 18% for SAs and 67% for MAs. CONCLUSION: In I-131 MIBG therapy for PPGLs, multiple administrations significantly increased only Grade 1 or 2 lymphopenia and leukopenia compared to single administration. - A prospective study of surgeons' workloads and associated factors in real-world practice.
Shigeru Harada, Takashige Abe, Jun Furumido, Keita Takahashi, Kanta Hori, Noriyuki Abe, Masafumi Kon, Sachiyo Murai, Haruka Miyata, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Nobuo Shinohara
Scientific reports, 14, 1, 9741, 9741, 28 Apr. 2024, [International Magazine]
English, Scientific journal, New technologies such as laparoscopic and robotic surgery are spreading, and there is a demand for physicians to keep up with novel methods. In contrast to the recent focus on healthcare professional burnout, the mental and physical costs during surgery are not well-understood. We aimed to quantify surgeons' workloads in daily urological surgical practice and clarify potential background factors associated with such workloads. Urologists in Hokkaido, Japan, were invited to this study. Between December 2020 and December 2021, participants repeatedly reported workloads, which were assessed using the National Aeronautics and Space Administration-Task Load Index (NASA-TLX), after each surgery in conjunction with participants' names, patients' backgrounds, their roles (independent operator, operator under supervision, instructor, and 1st or 2nd assistant), and surgical outcomes, via SurveyMonkey®. Because of the heterogeneity among individuals, a linear mixed-effects model was utilized to analyze factors associated with NASA-TLX, calculating the parameter estimates (PE) of regression coefficients for each factor and their 95% confidence interval (CI). Sixty-five urologists (5 women) joined the study, and 2169 data were collected within 7 days after surgeries. A linear mixed-effects model revealed that female surgeons (PE + 15.56, 95% CI 2.36-28.77), urgent/emergency surgery (PE + 6.65, 95% CI 4.59-8.70), intraoperative complications (PE + 9.26, 95% CI 6.76-11.76), and near-miss incidents (PE + 3.81, 95% CI 2.27-5.36) were associated with higher workloads. Regarding the surgeons' role, operator under supervision (PE + 12.46, 95% CI 9.86-15.06) showed the highest workloads. Surgeons' workloads decreased as the number of previous cases of the same procedure increased. Surgeons' workloads were associated with various factors. Given that the highest workloads were for operators under supervision, instructors should be aware of trainees' high workloads and devise appropriate instructional interventions. - Physiotherapy for continence and muscle function in prostatectomy: a randomised controlled trial.
Mifuka Ouchi, Takeya Kitta, Hiroki Chiba, Madoka Higuchi, Yui Abe-Takahashi, Mio Togo, Naohisa Kusakabe, Sachiyo Murai, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Takashige Abe, Nobuo Shinohara
BJU international, 24 Apr. 2024, [International Magazine]
English, Scientific journal, OBJECTIVE: To assess the effectiveness of pre- and postoperative supervised pelvic floor muscle training (PFMT) on the recovery of continence and pelvic floor muscle (PFM) function after robot-assisted laparoscopic radical prostatectomy (RARP). PATIENTS AND METHODS: We carried out a single-blind randomised controlled trial involving 54 male patients scheduled to undergo RARP. The intervention group started supervised PFMT 2 months before RARP and continued for 12 months after surgery with a physiotherapist. The control group was given verbal instructions, a brochure about PFMT, and lifestyle advice. The primary outcome was 24-h pad weight (g) at 3 months after RARP. The secondary outcomes were continence status (assessed by pad use), PFM function, and the Expanded Prostate Cancer Index Composite (EPIC) score. RESULTS: Patients who participated in supervised PFMT showed significantly improved postoperative urinary incontinence (UI) compared with the control group (5.0 [0.0-908.0] g vs 21.0 [0.0-750.0] g; effect size: 0.34, P = 0.022) at 3 months after RARP based on 24-h pad weight. A significant improvement was seen in the intervention compared with the control group (65.2% continence [no pad use] vs 31.6% continence, respectively) at 12 months after surgery (effect size: 0.34, P = 0.030). Peak pressure during a maximum voluntary contraction was higher in the intervention group immediately after catheter removal and at 6 months, and a longer duration of sustained contraction was found in the intervention group compared with the control group. We were unable to demonstrate a difference between groups in EPIC scores. CONCLUSION: Supervised PFMT can improve postoperative UI and PFM function after RARP. Further studies are needed to confirm whether intra-anal pressure reflects PFM function and affects continence status in UI in men who have undergone RARP. - 切除不能/転移性PPGLにおけるI-131 MIBG治療後シンチグラフィーで非集積病変を有する患者の予測因子に関する検討
竹中 淳規, 渡邊 史郎, 安部 崇重, 土川 貴裕, 竹内 啓, 平田 健司, 木村 理奈, 若林 直人, 篠原 信雄, 工藤 與亮
日本内分泌外科学会雑誌, 41, Suppl.1, S202, S202, (一社)日本内分泌外科学会, Apr. 2024
Japanese - Cross-sectional and longitudinal analyses of urinary extracellular vesicle mRNA markers in urothelial bladder cancer patients.
Taku Murakami, Keita Minami, Toru Harabayashi, Satoru Maruyama, Norikata Takada, Akira Kashiwagi, Haruka Miyata, Yasuyuki Sato, Ryuji Matsumoto, Hiroshi Kikuchi, Takashige Abe, Yoichi M Ito, Sachiyo Murai, Nobuo Shinohara, Hiroshi Harada, Takahiro Osawa
Scientific reports, 14, 1, 6801, 6801, 21 Mar. 2024, [International Magazine]
English, Scientific journal, We designed this multi-center prospective study with the following objectives: (1) the cross-sectional validation of extracellular vesicles (EV) mRNA markers to detect urothelial bladder cancer (UBC) before transurethral resection of bladder cancer (TURBT), and (2) the longitudinal validation of EV mRNA markers to monitor non-muscle invasive bladder cancer (NMIBC) recurrence after TURBT. EV mRNA markers evaluated in this study were KRT17, GPRC5A, and SLC2A1 in addition to two additional markers from literatures, MDK and CXCR2, and measured by quantitative RT-PCR with normalization by a reference gene (ALDOB). Diagnostic performances of EV mRNA markers were compared to conventional markers. Regarding the first objective, we confirmed that EV mRNA biomarkers in urine were higher in UBC patients, particularly those with higher stage/grade tumors, than in those without UBC (n = 278 in total) and the diagnostic performance of EV mRNA MDK and KRT17 outperformed conventional biomarkers with AUC 0.760 and 0.730, respectively. Concerning the second objective, we prospectively analyzed the time courses of EV mRNA markers while NMIBC patients (n = 189) (median follow-up 19 months). The expression of EV mRNA KRT17 was significantly high in patients with recurrence, while it gradually decreased over time in those without recurrence (p < 0.01). - Gap analysis between trainees' subjective competencies and the competencies expected by instructors in urology: A need assessment survey in Japan
Kanta Hori, Takashige Abe, Noriyuki Abe, Junya Abe, Kazufumi Okada, Keita Takahashi, Shigeru Harada, Jun Furumido, Sachiyo Murai, Masafumi Kon, Kohei Hashimoto, Naoya Masumori, Hidehiro Kakizaki, Nobuo Shinohara
International Journal of Urology, Wiley, 17 Feb. 2024
Scientific journal, Objective
According to the rapid progress in surgical techniques, a growing number of procedures should be learned during postgraduate training periods. This study aimed to clarify the current situation regarding urological surgical training and identify the perception gap between trainees' competency and the competency expected by instructors in Japan.
Methods
Regarding the 40 urological surgical procedures selected via the Delphi method, we collected data on previous caseloads, current subjective autonomy, and confidence for future skill acquisition from trainees (<15 post‐graduate years [PGY]), and the competencies when trainees became attending doctors expected by instructors (>15 PGY), according to a 5‐point Likert scale. In total, 174 urologists in Hokkaido Prefecture, Japan were enrolled in this study.
Results
The response rate was 96% (165/174). In a large proportion of the procedures, caseloads grew with accumulation of years of clinical practice. However, trainees had limited caseloads of robotic and reconstructive surgeries even after 15 PGY. Trainees showed low subjective competencies at present and low confidence for future skill acquisition in several procedures, such as open cystectomy, ureteroureterostomy, and ureterocystostomy, while instructors expected trainees to be able to perform these procedures independently when they became attending doctors.
Conclusion
Trainees showed low subjective competencies and low confidence for future skill acquisition in several open and reconstructive procedures, while instructors considered that these procedures should be independently performable by attending doctors. We believe that knowledge of these perception gaps is helpful to develop a practical training program. - The impact of second transurethral resection on survival outcomes in patients with non-muscle-invasive bladder cancer treated with bacillus Calmette-Guérin therapy
Hiroshi Kikuchi, Takashige Abe, Makito Miyake, Haruka Miyata, Ryuji Matsumoto, Takahiro Osawa, Nobutaka Nishimura, Kiyohide Fujimoto, Junichi Inokuchi, Takahiro Yoneyama, Ryotaro Tomida, Kazuyuki Numakura, Yuto Matsushita, Kazumasa Matsumoto, Takuma Sato, Rikiya Taoka, Takashi Kobayashi, Takahiro Kojima, Yoshiyuki Matsui, Naotaka Nishiyama, Hiroshi Kitamura, Hiroyuki Nishiyama, Nobuo Shinohara
Japanese Journal of Clinical Oncology, 54, 2, 192, 200, 01 Feb. 2024
Scientific journal - 切除不能/転移性PPGLにおけるMIBG治療前のFDG-PETの集積性に関する検討
竹中 淳規, 渡邊 史郎, 安部 崇重, 土川 貴裕, 竹内 啓, 平田 健司, 木村 理奈, 石井 宙史, 若林 直人, 工藤 與亮
核医学, 61, Suppl., S169, S169, (一社)日本核医学会, 2024
Japanese - High complexity tumorを含む片側多発腎腫瘍に対する冷却併用ロボット支援腎部分切除術
松本 隆児, 安部 崇重, 篠原 信雄
日本内視鏡外科学会雑誌, 28, 7, 1167, 1167, (一社)日本内視鏡外科学会, Dec. 2023
Japanese - 客観的フィードバックが得られる腹腔鏡手術トレーニングモデル構築の試み
安部 崇重, 松本 隆児, 堀田 記世彦, 七戸 俊明, 倉島 庸, 篠原 信雄
日本内視鏡外科学会雑誌, 28, 7, 2919, 2919, (一社)日本内視鏡外科学会, Dec. 2023
Japanese - 免疫複合療法後に鏡視下腫瘍減量腎摘除術を行った4例
大澤 崇宏, 東海林 旺次朗, 永森 聖人, 上條 千太, 森口 卓哉, 堀 寛太, 宮田 遥, 松本 隆児, 安部 崇重, 篠原 信雄
日本泌尿器内視鏡・ロボティクス学会総会, 37回, O, 3, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2023
Japanese - ロボット支援下膀胱全摘術後に閉鎖神経による内ヘルニアをきたした一例
吉田 あゆ, 大澤 崇宏, 宮田 遥, 松本 隆児, 安部 崇重, 内藤 善, 和田 雅孝, 村上 壮一, 平野 聡, 篠原 信雄
日本泌尿器内視鏡・ロボティクス学会総会, 37回, O, 5, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2023
Japanese - カダバートレーニング時の鉗子動態計測による手術技量の数値化の試み
安部 崇重, 今 雅史, 堀田 記世彦, 樋口 まどか, 菊地 央, 上條 千太, 宮田 遥, 松本 隆児, 大澤 崇宏, 篠原 信雄
日本泌尿器内視鏡・ロボティクス学会総会, 37回, O, 6, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2023
Japanese - 精巣腫瘍に対する腹腔鏡下神経温存両側後腹膜リンパ節郭清術の経験
松本 隆児, 宮田 遥, 上條 千太, 東海林 旺次朗, 森口 卓哉, 堀 寛太, 永森 聖人, 大澤 崇宏, 安部 崇重, 篠原 信雄
日本泌尿器内視鏡・ロボティクス学会総会, 37回, O, 1, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2023
Japanese - 【バイプレーヤーズ!転移性癌治療における外科治療の役割,徹底解明】(Part 1)薬物治療が進歩した今,転移性癌の原発巣切除は勧められるか!? 転移性尿路上皮癌の原発巣切除は勧められるか?
安部 崇重, 宮田 遥, 松本 隆児, 大澤 崇宏, 篠原 信雄
泌尿器外科, 36, 10, 1091, 1095, 医学図書出版(株), Oct. 2023
Japanese - 増やそう未来の外科医!働き方改革における外科系教育 泌尿器科手術に関するシミュレーショントレーニング 当科での経験
安部 崇重, 今 雅史, 樋口 まどか, 堀田 記世彦, 菊地 央, 古御堂 純, 岩原 直也, 山田 修平, 原田 茂, 上條 千太, 村井 祥代, 宮田 遥, 松本 隆児, 大澤 崇宏, 篠原 信雄
日本癌治療学会学術集会抄録集, 61回, SWS7, 1, (一社)日本癌治療学会, Oct. 2023
English - [A Case of Testicular Cancer with Solitary Iliac Bone Metastasis].
Hajime Miyata, Takashige Abe, Naoya Iwahara, Hiroshi Kikuchi, Hiroki Chiba, Ryuji Matsumoto, Takahiro Osawa, Hiroshi Tanaka, Ken Morita, Tomoko Mitsuhashi, Nobuo Shinohara
Hinyokika kiyo. Acta urologica Japonica, 69, 9, 259, 264, Sep. 2023, [Domestic magazines]
Japanese, Scientific journal, A 23-year-old male was aware of pain around his left hip joint and visited a nearby orthopedic clinic. Swelling of the right testis was pointed out, and a testicular tumor was suspected. He was referred to the urology department of a local hospital. Blood analysis showed an increase of α-fetoprotein (AFP) (3,620 ng/ml). Computed tomographic (CT) -scan revealed a left iliac bone metastasis and morbid fracture. Right radical inguinal orchiectomy was performed. The pathological examination revealed mixed germ cell tumor (embryonic carcinoma and immature teratoma: 70%, seminoma: 30%). The diagnosis was non-seminomatous germ cell tumor, stage IIIc, and poor risk on the International Germ Cell Consensus Classification. After one cycle of a bleomycin, etoposide and cisplatinum (BEP) regimen, he was referred to our hospital. After a total of 4 cycles of BEP, AFP was normalized. Denosumab was also administered monthly. The CT-scan showed a reduction of bone metastasis and recovery of ossification. Bone biopsy did not show viable tumor cells. Because extirpation of the remaining mass would require resection of the left part of the pelvic bone with significant functional loss of the left limb, we performed close follow-up after an additional 2 courses of the etoposide and cisplatin regimen. The patient is currently alive without recurrence at 45 months after the last systemic chemotherapy. - Think different in the bridge between pathology and clinical site 臨床経験・エビデンスから考察するmicropapillary subtypeの治療戦略
大澤 崇宏, 山田 修平, 宮田 遥, 松本 隆児, 安部 崇重, 篠原 信雄
泌尿器外科, 36, 臨増, 704, 704, 医学図書出版(株), Aug. 2023
Japanese - Think different in metastatic RCC treatment 免疫チェックポイント阻害薬時代におけるCytoreductive nephrectomy(CN)の意義
大澤 崇宏, 菊地 央, 山田 修平, 宮田 遥, 松本 隆児, 安部 崇重, 篠原 信雄
泌尿器外科, 36, 臨増, 788, 789, 医学図書出版(株), Aug. 2023
Japanese - 膀胱癌術後患者における日本語版Body Image Scaleの信頼性と妥当性の検証
樋口 まどか, 佐藤 三穂, 大澤 崇宏, 山田 修平, 宮田 遥, 松本 隆児, 田中 博, 佐々木 芳浩, 森田 研, 原林 透, 柏木 明, 村井 祥代, 安部 崇重, 小笠原 克彦, 篠原 信雄
泌尿器外科, 36, 臨増, 886, 886, 医学図書出版(株), Aug. 2023
Japanese - Impact of postoperative complications on long-term survival in bladder cancer patients.
Takashige Abe, Shuhei Yamada, Hiroshi Kikuchi, Ataru Sazawa, Hidenori Katano, Hidetaka Suzuki, Ichiro Takeuchi, Keita Minami, Ken Morita, Kunihiko Tsuchiya, Norikata Takada, Shintaro Maru, Soshu Sato, Takanori Yamashita, Tango Mochizuki, Tomoshige Akino, Yoshihiro Sasaki, Yuichiro Shinno, Norihiro Murahashi, Takafumi Kawazu, Jun Furumido, Haruka Miyata, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Nobuo Shinohara
Japanese journal of clinical oncology, 17 Jul. 2023, [International Magazine]
English, Scientific journal, OBJECTIVE: To determine the impact of postoperative complications on long-term survival outcomes in patients with bladder cancer undergoing radical cystectomy. METHODS: This retrospective multi-institutional study included 766 bladder cancer patients who underwent radical cystectomy between 2011 and 2017. Patient characteristics, perioperative outcomes, all complications within 90 days after surgery and survival outcomes were collected. Each complication was graded based on the Clavien-Dindo system, and grouped using a standardized grouping method. The Comprehensive Complication Index, which incorporates all complications into a single formula weighted by their severity, was utilized. Overall survival and recurrence-free survival (local, distant or urothelial recurrences) were stratified by Comprehensive Complication Index (high: ≥26.2; low: <26.2). A multivariate model was utilized to identify independent prognostic factors. RESULTS: The incidence of any and major complications (≥Clavien-Dindo grade III) was 70 and 24%, respectively. In terms of Comprehensive Complication Index, 34% (261/766) of the patients had ≥26.2. Patients with Comprehensive Complication Index ≥ 26.2 had shorter overall survival (4-year, 59.5 vs. 69.8%, respectively, log-rank test, P = 0.0037) and recurrence free survival (51.9 vs. 60.1%, respectively, P = 0.0234), than those with Comprehensive Complication Index < 26.2. The Cox multivariate model identified the age, performance status, pT-stage, pN-stage and higher CCI (overall survival: HR = 1.35, P = 0.0174, recurrence-free survival: HR = 1.26, P = 0.0443) as independent predictors of both overall survivial and recurrence-free survival. CONCLUSIONS: Postoperative complications assessed by Comprehensive Complication Index had adverse effects on long-term survival outcomes. Physicians should be aware that major postoperative complications can adversely affect long-term disease control. - 日本語版Body Image Scaleの膀胱癌術後患者における信頼性・妥当性の検証
樋口 まどか, 佐藤 三穂, 大澤 崇宏, 山田 修平, 宮田 遥, 菊地 央, 松本 隆児, 三浪 圭太, 田中 博, 佐々木 芳浩, 森田 研, 高田 徳容, 原林 透, 古御堂 純, 柏木 明, 村井 祥代, 安部 崇重, 小笠原 克彦, 篠原 信雄
泌尿器外科, 36, 5, 417, 417, 医学図書出版(株), May 2023
Japanese - 過去20年間の根治的膀胱全摘除術後周術期合併症の検討 周術期アウトカムの改善は得られているか
山田 修平, 安部 崇重, 佐澤 陽, 片野 英典, 鈴木 英孝, 竹内 一郎, 石崎 淳司, 三浪 圭太, 森田 研, 土屋 邦彦, 高田 徳容, 丸 晋太朗, 石川 修平, 佐藤 聡秋, 河津 隆文, 山下 孝典, 小野 武紀, 望月 端吾, 秋野 文臣, 佐々木 芳浩, 信野 祐一郎, 古御堂 純, 宮田 遥, 菊地 央, 松本 隆児, 大澤 崇宏, 篠原 信雄
泌尿器外科, 36, 5, 420, 420, 医学図書出版(株), May 2023
Japanese - 妊娠中に発見されたパラガングリオーマに対して腹腔鏡下腫瘍摘除術を施行した1例
細川 智加, 安部 崇重, 菊地 央, 森田 研, 山田 修平, 宮田 遥, 松本 隆児, 大澤 崇宏, 篠原 信雄
泌尿器外科, 36, 5, 423, 423, 医学図書出版(株), May 2023
Japanese - 泌尿器科医師が手術時に感じるメンタルワークロードに関する前向き観察研究
原田 茂, 古御堂 純, 安部 崇重, 高橋 圭太, 今 雅史, 村井 祥代, 菊地 央, 宮田 遥, 松本 隆児, 大澤 崇宏, 篠原 信雄
泌尿器外科, 36, 5, 427, 427, 医学図書出版(株), May 2023
Japanese - 肺腫瘍血栓性微小血管症(PTTM)により急激な転帰を辿った転移性膀胱癌の2症例
宮田 遥, 大澤 崇宏, 山田 修平, 細川 智加, 星 達也, 坪内 駿, 松本 隆児, 安部 崇重, 中里 信一, 岩崎 沙理, 谷口 浩二, 谷川 聖, 田中 伸哉, 篠原 信雄
泌尿器外科, 36, 5, 428, 428, 医学図書出版(株), May 2023
Japanese - 根治的膀胱全摘除術術後合併症の長期予後への影響
安部 崇重, 山田 修平, 菊地 央, 佐澤 陽, 片野 英典, 鈴木 英孝, 竹内 一郎, 森 達也, 三浪 圭太, 森田 研, 土屋 邦彦, 高田 徳容, 丸 晋太郎, 河津 隆文, 石川 修平, 佐藤 聡秋, 山下 孝典, 望月 端吾, 秋野 文臣, 佐々木 芳浩, 信野 祐一郎, 古御堂 純, 松田 博幸, 宮田 遥, 松本 隆児, 大澤 崇宏, 篠原 信雄
泌尿器外科, 36, 5, 429, 429, 医学図書出版(株), May 2023
Japanese - 透析腎癌の最新の知見 透析腎癌の疫学
大澤 崇宏, 宮田 遥, 松本 隆児, 安部 崇重, 篠原 信雄
日本透析医学会雑誌, 56, Suppl.1, 299, 299, (一社)日本透析医学会, May 2023
Japanese - Clinical utility of single-shot echo-planar diffusion-weighted imaging using L1-regularized iterative sensitivity encoding in prostate MRI.
Noriko Nishioka, Noriyuki Fujima, Satonori Tsuneta, Masami Yoneyama, Ryuji Matsumoto, Takashige Abe, Rina Kimura, Keita Sakamoto, Fumi Kato, Kohsuke Kudo
Medicine, 102, 17, e33639, 25 Apr. 2023, [International Magazine]
English, Scientific journal, We investigated the ability of echo-planar imaging with L1-regularized iterative sensitivity encoding-based diffusion-weighted imaging (DWI) to improve the image quality and reduce the scanning time in prostate magnetic resonance imaging. We retrospectively analyzed 109 cases of prostate magnetic resonance imaging. We compared variables in the quantitative and qualitative assessments among 3 imaging groups: conventional parallel imaging-based DWI (PI-DWI) with an acquisition time of 3 minutes 15 seconds; echo-planar imaging with L1-regularized iterative sensitivity encoding-based DWI (L1-DWI) with a normal acquisition time (L1-DWINEX12) of 3 minutes 15 seconds; and L1-DWI with a half acquisition time (L1-DWINEX6) of 1 minute 45 seconds. As a quantitative assessment, the signal-to-noise ratio (SNR) of DWI (SNR-DWI), the contrast-to-noise ratio (CNR) of DWI (CNR-DWI), and the CNR of apparent diffusion coefficient were measured. As a qualitative assessment, the image quality and visual detectability of prostate carcinoma were evaluated. In the quantitative analysis, L1-DWINEX12 showed significantly higher SNR-DWI than PI-DWI (P = .0058) and L1-DWINEX6 (P < .0001). In the qualitative analysis, the image quality score for L1-DWINEX12 was significantly higher than those of PI-DWI and L1-DWINEX6. A non-inferiority assessment demonstrated that L1-DWINEX6 was non-inferior to PI-DWI in terms of both quantitative CNR-DWI and qualitative grading of image quality with a <20% inferior margin. L1-DWI successfully demonstrated a reduced scanning time while maintaining good image quality. - 高齢者のがん治療:薬物療法 膀胱がんに対する薬物療法
安部 崇重, 宮田 遥, 松本 隆児, 大澤 崇宏, 菊地 央, 篠原 信雄
日本老年泌尿器科学会誌, 36, 1, 37, 37, 日本老年泌尿器科学会, Apr. 2023
Japanese - 泌尿器科医師が手術時に感じるメンタルワークロードに関する前向き観察研究(Mental workloads of surgeons in urology: A prospective observational study)
原田 茂, 古御堂 純, 安部 崇重, 高橋 圭太, 今 雅史, 村井 祥代, 菊地 央, 宮田 遥, 松本 隆児, 大澤 崇宏, 篠原 信雄
日本泌尿器科学会総会, 110回, AOP12, 07, (一社)日本泌尿器科学会総会事務局, Apr. 2023
English - 泌尿器科医師における手術時に感じるメンタルワークロードのクラスター解析について(Cluster analysis of mental workloads of urologists: A prospective observational study)
古御堂 純, 原田 茂, 安部 崇重, 高橋 圭太, 今 雅史, 宮田 遥, 菊地 央, 松本 隆児, 大澤 崇宏, 村井 祥代, 篠原 信雄
日本泌尿器科学会総会, 110回, OP10, 03, (一社)日本泌尿器科学会総会事務局, Apr. 2023
English - 回腸導管造設後の尿管導管吻合狭窄発症のリスク因子(Risk factors of ureteroenteric anastomotic stricture after ileal conduit urinary diversion)
菊地 央, 安部 崇重, 山田 修平, 佐澤 陽, 三浪 圭太, 森田 研, 高田 徳容, 大石 悠一郎, 古御堂 純, 宮田 遥, 松本 隆児, 大澤 崇宏, 篠原 信雄
日本泌尿器科学会総会, 110回, OP43, 05, (一社)日本泌尿器科学会総会事務局, Apr. 2023
English - 膀胱全摘後術後合併症の長期予後への影響(Impact of postoperative complications on longterm survival after radical cystectomy)
安部 崇重, 山田 修平, 菊地 央, 佐澤 陽, 三浪 圭太, 森田 研, 高田 徳容, 秋野 文臣, 古御堂 純, 宮田 遥, 松本 隆児, 大澤 崇宏, 篠原 信雄
日本泌尿器科学会総会, 110回, OP59, 01, (一社)日本泌尿器科学会総会事務局, Apr. 2023
English - 尿管癌への放射線治療後に転移による直腸狭窄を来した1例
服部 敬寛, 西岡 健太郎, 橋本 孝之, 大塚 愛美, 木下 留美子, 青山 英史, 安部 崇重, 大澤 崇宏, 松本 隆児, 菊地 央, 篠原 信雄, 高桑 恵美
Japanese Journal of Radiology, 41, Suppl., 4, 4, (公社)日本医学放射線学会, Feb. 2023
Japanese - 褐色細胞腫・傍神経節腫に対するI-131MIBG治療の単回投与と複数回投与での有害事象発生率の検討
若林 直人, 渡邊 史郎, 安部 崇重, 竹中 淳規, 平田 健司, 篠原 信雄, 工藤 與亮
核医学, 60, Suppl., S216, S216, (一社)日本核医学会, 2023
Japanese - Development and validation of a measurement system for laparoscopic surgical procedures in practical surgery training.
Koki Ebina, Takashige Abe, Kiyohiko Hotta, Madoka Higuchi, Jun Furumido, Naoya Iwahara, Masafumi Kon, Shunsuke Komizunai, Yo Kurashima, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Teppei Tsujita, Kazuya Sase, XiaoShuai Chen, Nobuo Shinohara, Atsushi Konno
IEEE/SICE International Symposium on System Integration(SII), 1, 6, IEEE, 2023, [Peer-reviewed]
International conference proceedings - Validation of the Japanese version of the Body Image Scale for bladder cancer patients.
Miho Sato, Takahiro Osawa, Takashige Abe, Michitaka Honda, Madoka Higuchi, Shuhei Yamada, Jun Furumido, Hiroshi Kikuchi, Ryuji Matsumoto, Yasuyuki Sato, Yoshihiro Sasaki, Toru Harabayashi, Satoru Maruyama, Norikata Takada, Keita Minami, Hiroshi Tanaka, Ken Morita, Akira Kashiwagi, Sachiyo Murai, Yoichi M Ito, Katsuhiko Ogasawara, Nobuo Shinohara
Scientific reports, 12, 1, 21544, 21544, 13 Dec. 2022, [International Magazine]
English, Scientific journal, The Body Image Scale (BIS) is a 10-item tool that measures the body images of cancer patients. This study aims to validate the Japanese version of the BIS for bladder cancer patients. A multicenter cross-sectional survey was used to identify the participants, which included Japanese bladder cancer patients. The percentage of missing responses, internal consistency, and known-group validity were evaluated. The correlations between the BIS and two HRQOL instruments (the Bladder Cancer Index and the SF-12) were assessed to determine convergent validity. Among 397 patients, 221 patients were treated by transurethral resection of bladder tumor (TURBT) endoscopically, 49 patients underwent cystectomy with neobladder, and 127 patients underwent cystectomy involving stoma. The percentage of missing responses in the BIS ranged from 8.1 to 15.6%. Cronbach's α coefficient was 0.924. Higher BIS scores indicate negative body image, and the median BIS score for patients with native bladders after TURBT (0.5) was significantly lower than those of the patients with neobladder (4.0) and stoma formation (7.0), which indicated the discriminatory ability of the BIS. Each domain of the Bladder Cancer Index and the role summary score of the SF-12 correlated to the BIS scores, which confirmed the convergent validity. A range of BIS scores were identified among patients who reported similar physical summary scores and mental summary scores of the SF-12. This study confirmed the reliability and validity of the Japanese version of the BIS for bladder cancer patients. - IMAGENE trial: multicenter, proof-of-concept, phase II study evaluating the efficacy and safety of combination therapy of niraparib with PD-1 inhibitor in solid cancer patients with homologous recombination repair genes mutation.
Taigo Kato, Nobuaki Matsubara, Masaki Shiota, Masatoshi Eto, Takahiro Osawa, Takashige Abe, Nobuo Shinohara, Yota Yasumizu, Nobuyuki Tanaka, Mototsugu Oya, Koshiro Nishimoto, Takuji Hayashi, Masashi Nakayama, Takahiro Kojima, Kenjiro Namikawa, Takao Fujisawa, Susumu Okano, Eisuke Hida, Yoshiaki Nakamura, Hideaki Bando, Takayuki Yoshino, Norio Nonomura
BMC cancer, 22, 1, 1292, 1292, 09 Dec. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: Previous clinical trials have demonstrated the potential efficacy of poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) in patients with cancer involving homologous recombination repair (HRR) gene-mutation. Moreover, HRR gene-mutated cancers are effectively treated with immune checkpoint inhibitors (ICIs) with the increase in tumor mutation burden. We have proposed to conduct a multicenter, single-arm phase II trial (IMAGENE trial) for evaluating the efficacy and safety of niraparib (PARPi) plus programmed cell death-1 inhibitor combination therapy in patients with HRR gene-mutated cancers who are refractory to ICIs therapy using a next generation sequencing-based circulating tumor DNA (ctDNA) and tumor tissue analysis. METHODS: Key eligibility criteria for this trial includes HRR gene-mutated tumor determined by any cancer gene tests; progression after previous ICI treatment; and Eastern Cooperative Oncology Group Performance Status ≤ 1. The primary endpoint is the confirmed objective response rate (ORR) in all patients. The secondary endpoints include the confirmed ORR in patients with HRR gene-mutation of ctDNA using the Caris Assure (CARIS, USA). The target sample size of the IMAGENE trial is 57 patients. Biomarker analyses will be performed in parallel using the Caris Assure, proteome analysis, and T cell repertoire analysis to reveal tumor immunosurveillance in peripheral blood. EXPECTED OUTCOME: Our trial aims to confirm the clinical benefit of PARPi plus ICI combination therapy in ICI-resistant patients. Furthermore, through translational research, our trial will shed light on which patients would benefit from the targeted combination therapy for patients with HRR gene-mutated tumor even after the failure of ICIs. TRIAL REGISTRATION: The IMAGENE trial: jRCT, Clinical trial no.: jRCT2051210120, Registered date: November 9, 2021. - 鉗子動態計測を用いた腹腔鏡手術基本手技の技量評価・客観的フィードバックの試み
安部 崇重, 堀田 記世彦, 松本 隆児, 倉島 庸, 篠原 信雄
日本内視鏡外科学会雑誌, 27, 7, 1418, 1418, (一社)日本内視鏡外科学会, Dec. 2022
Japanese - RAPN アプローチ別、機種別 RAPN 経腹アプローチ Da Vinci Xi
安部 崇重, 山田 修平, 宮田 遥, 松本 隆児, 大澤 崇宏, 菊地 央, 篠原 信雄
日本泌尿器内視鏡・ロボティクス学会総会, 36回, SY, 2, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2022
Japanese - 鉗子動態計測を用いた腹腔鏡手術基本手技の技量評価・客観的フィードバックの試み
安部 崇重, 堀田 記世彦, 古御堂 純, 岩原 直也, 今 雅史, 樋口 まどか, 菊地 央, 松本 隆児, 大澤 崇宏, 篠原 信雄
日本泌尿器内視鏡・ロボティクス学会総会, 36回, AP, 7, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2022
Japanese - 妊娠中に発見されたパラガングリオーマに対して腹腔鏡下腫瘍摘除術を施行した一例
細川 智加, 安部 崇重, 菊地 央, 森田 研, 山田 修平, 宮田 遥, 松本 隆児, 大澤 崇宏, 篠原 信雄
日本泌尿器内視鏡・ロボティクス学会総会, 36回, V, 4, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2022
Japanese - 腎部分切除術後同側腎に再発した腎門部腎腫瘍に対するロボット支援腎部分切除術の経験
松本 隆児, 山田 修平, 宮田 遥, 大澤 崇宏, 安部 崇重, 篠原 信雄
日本泌尿器内視鏡・ロボティクス学会総会, 36回, V, 3, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2022
Japanese - 膀胱全摘+回腸導管造設後の上部尿路再発にたいする後腹膜鏡下腎尿管全摘の2例
菊地 央, 安部 崇重, 大澤 崇宏, 山田 修平, 古御堂 純, 宮田 遥, 松本 隆児, 篠原 信雄
日本泌尿器内視鏡・ロボティクス学会総会, 36回, V, 7, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2022
Japanese - 前立腺癌に対し動体追尾強度変調放射線療法後にロボット支援膀胱全摘術を施行した2例
保坂 雪野, 大澤 崇宏, 山田 修平, 宮田 遥, 松本 隆児, 安部 崇重, 篠原 信雄
日本泌尿器内視鏡・ロボティクス学会総会, 36回, O, 3, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2022
Japanese - TURBTチェックリスト(CL)を導入前後での治療成績の比較
大澤 崇宏, 菊地 央, 山田 修平, 宮田 遥, 松本 隆児, 安部 崇重, 村井 祥代, 篠原 信雄
日本泌尿器内視鏡・ロボティクス学会総会, 36回, O, 7, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2022
Japanese - Stroma biglycan expression can be a prognostic factor in prostate cancers
Jun Furumido, Nako Maishi, Aya Yanagawa‐Matsuda, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Takashige Abe, Yoshihiro Matsuno, Nobuo Shinohara, Yasuhiro Hida, Kyoko Hida
International Journal of Urology, 30, 2, 147, 154, Wiley, 28 Oct. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: This study analyzes the relationship between biglycan expression in prostate cancer and clinicopathological parameters to clarify the potential link between biglycan and prognosis and progression to castration-resistant prostate cancer (CRPC). METHODS: We retrospectively analyzed 60 cases of prostate cancer patients who underwent robot-assisted laparoscopic radical prostatectomy in Hokkaido University Hospital. RESULTS: Biglycan was expressed in the tumor stroma but not in tumor cells. There was no significant relationship with biochemical recurrence (p = 0.5237), but the expression of biglycan was 36.1% in the group with progression to CRPC. This indicates a significant relationship with progression to CRPC (p = 0.0182). Furthermore, the expression of biglycan-positive blood vessels was significantly higher (15.9%) in the group with biochemical recurrence than in the group without biochemical recurrence (8.5%) (p = 0.0169). The biglycan-positive vessels were 28.6% in the group with progression to CRPC, which was significantly higher than that in the group without progression to CRPC (p < 0.0001). CONCLUSION: This is the first study to show that stroma biglycan is a useful prognostic factor for prostate cancer. - Prognostic value of [18F]FDG-PET prior to [131I]MIBG treatment for pheochromocytoma and paraganglioma (PPGL).
Junki Takenaka, Shiro Watanabe, Takashige Abe, Kenji Hirata, Yuko Uchiyama, Rina Kimura, Nobuo Shinohara, Kohsuke Kudo
Annals of nuclear medicine, 27 Oct. 2022, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, OBJECTIVE: Pheochromocytomas and paragangliomas (PPGLs) are rare tumors arising from the neural crest cells that form the sympathetic and parasympathetic nervous systems. Radiotherapy with [131I]metaiodobenzylguanidine (MIBG) is recommended for unresectable PPGLs. We investigated the usefulness of the metabolic tumor volume (MTV) and total lesion glycolysis (TLG) derived from [18F]fluorodeoxyglucose-positron emission tomography (FDG-PET) for predicting the prognosis of patients with unresectable PPGL(s) before receiving [131I]MIBG therapy. PATIENTS AND METHODS: We retrospectively analyzed the cases of 25 patients with unresectable PPGLs treated with [131I]MIBG at our hospital between 2001 and 2020. The MTV and TLG were measured in reference to liver accumulation. We divided the patients into two groups based on median values for the maximum standardized uptake value (SUVmax), MTV, and TLG, and evaluated between-group differences using log-rank tests. Cox proportional hazards models were used to determine whether there were significant differences in prognosis with respect to tumor type (pheochromocytoma vs. paraganglioma), site of metastasis, age, past treatment (chemotherapy, external radiation or [131I]MIBG treatment before the current [131I]MIBG treatment), urinary catecholamine, SUVmax, MTV, and TLG. RESULTS: The median follow-up time was 42 months (range 2-136 months). The median overall survival was 63 months. The overall survival (OS) was significantly shorter in the high-MTV group (log-rank test, p = 0.049) and the high-TLG group (p = 0.049), with no significant difference between the high- and low-SUVmax groups (p = 0.19). Likewise, there was no significant difference in prognosis according to pheochromocytoma or paraganglioma, metastasis location, age, or prior chemotherapy. A history of external radiation before [131I]MIBG treatment was associated with a significantly worse prognosis (hazard ration [HR] = 7.95, p = 0.0018). Urinary adrenaline and noradrenaline were not significant prognostic factors (p = 0.70, p = 0.25, respectively), but urinary dopamine did predict a worse outcome (p = 0.022). There was no increased risk of death for higher SUVmax or TLG (p = 0.63 and 0.057, respectively), but higher MTV did predict a worse outcome (HR = 7.27, p = 0.029). CONCLUSION: High MTV and high TLG were significantly associated with a poor prognosis after [131I]MIBG therapy for PPGLs. Other treatment strategies for such patients may need to be explored. - Late recurrence in patients with non-muscle-invasive bladder cancer after 5-year cancer-free periods.
Yurie Hirata, Madoka Higuchi, Takahiro Osawa, Shiro Hinotsu, Toru Harabayashi, Tango Mochizuki, Nobuyasu Enami, Osamu Nounaka, Yuichiro Shinno, Hiroshi Kikuchi, Ryuji Matsumoto, Takashige Abe, Sachiyo Murai, Nobuo Shinohara
International journal of urology : official journal of the Japanese Urological Association, 29, 10, 1140, 1146, Oct. 2022, [International Magazine]
English, Scientific journal, OBJECTIVES: There is no consensus about the follow-up schedule after 5-year cancer-free periods. In this study, we aimed to elucidate the risk factors for the recurrence in patients with non-muscle-invasive bladder cancer who remained cancer free for more than 5 years. METHODS: Data from six Japanese institutions were retrospectively reviewed. Among the patients with non-muscle-invasive bladder cancer who were treated with transurethral resection of bladder tumor between 1990 and 2013, those who had no recurrence for more than 5 years were included in this study. The Kaplan-Meier method and Cox hazards model were used to estimate recurrence-free survival and to determine the pathologic and clinical factors affecting late recurrence. RESULTS: In total, 434 patients were enrolled in this study. Of these patients, 55 patients (12.7%) experienced late recurrence. The median follow-up time was 8.9 years (interquartile range 6.9-11.3 years). Prior history of bladder cancer before the most recent transurethral resection was a significant predictor for late recurrence (hazard ratio 1.99 [95% confidence interval 1.13-3.47], P = 0.019), although other clinical factors including tumor grade, pathologic stage, tumor multiplicity, and current risk classification systems were not associated with late recurrence. CONCLUSIONS: Late recurrence after a long tumor-free period is not rare and it was not predicted by current risk classification systems. Only prior history of bladder cancer was a significant predictor for late recurrence in this study. - Objective evaluation of laparoscopic surgical skills in wet lab training based on motion analysis and machine learning
Koki Ebina, Takashige Abe, Kiyohiko Hotta, Madoka Higuchi, Jun Furumido, Naoya Iwahara, Masafumi Kon, Kou Miyaji, Sayaka Shibuya, Yan Lingbo, Shunsuke Komizunai, Yo Kurashima, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Teppei Tsujita, Kazuya Sase, Xiaoshuai Chen, Atsushi Konno, Nobuo Shinohara
Langenbeck's Archives of Surgery, 407, 5, 2123, 2132, Aug. 2022, [Peer-reviewed]
English, Scientific journal - Metastatic neuroendocrine carcinoma of right adrenal gland successfully treated with laparoscopic adrenalectomy after multimodal therapy
Yusuke Yamagata, Takashige Abe, Naoya Iwahara, Kohichi Takada, Yasuhiro Hida, Emi Takakuwa, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Nobuo Shinohara
IJU Case Reports, Wiley, 29 Jul. 2022
Scientific journal - THE DEVELOPMENT OF SKILL EVALUATION SYSTEM FOR LAPAROSCOPIC SURGICAL PROCEDURE
EBINA KOKI, ABE TAKASHIGE, HOTTA KIYOHIKO, HIGUCHI MADOKA, FURUMIDO JUN, IWAHARA NAOYA, KON MASAFUMI, KOMIZUNAI SHUNSUKE, KURASHIMA YO, KIKUCHI HIROSHI, MATSUMOTO RYUJI, OSAWA TAKAHIRO, MURAI SACHIYO, TSUJITA TEPPEI, SASE KAZUYA, CHEN XIAOSHUAI, SHINOHARA NOBUO, KONNO ATSUSHI
Proceedings of Jc-IFToMM International Symposium, 5, 73, 79, Japanese Council of IFToMM, 16 Jul. 2022
English, This paper describes details of the development of skill evaluation system for laparoscopic surgical procedure. The measurement experiment was conducted for 70 surgeons, and the participants perform 2 tasks: tissue dissection around the aorta and renal parenchymal suturing/knotting using porcine cadaver. In the experiments, the movement of surgical instruments were recorded by motion capture (MoCap) system, and the motion indices were calculated. The participants grouped into three classes (novices, intermediates, and experts) according to their level of experience. Three classification algorithms: support vector machine (SVM), principal component based SVM (PCA-SVM), gradient boosting decision tree (GBDT) were utilized for developing the model of classifier. The accuracy of each model was assessed by nested and repeated k-fold cross validation. Regarding 3-class classification, the GBDT method resulted highest accuracy (the median of the accuracy is A_med = 68.6 %) in the dissection tasks. In the suturing/knotting tasks, PCA-SVM resulted highest accuracy (A_med = 58.4 %). Regarding 2-class classification (experts vs. intermediates/novices), the GBDT method resulted A_med = 72.9 % in the dissection task, and the PCA-SVM method resulted A_med = 69.2 % in the suturing task. This result shows the MoCap based skill evaluation system in wet-lab training could be a practical way to objectively assess trainees' surgical competence. - Imaging findings of ovarian metastasis of primary renal cell carcinoma: A case report and literature review.
Ayumi Takayanagi, Fumi Kato, Ayako Nozaki, Ryuji Matsumoto, Takahiro Osawa, Ken Kuwahara, Yoshihiro Matsuno, Hiroshi Asano, Tatsuya Kato, Hidemichi Watari, Takashige Abe, Nobuo Shinohara, Kohsuke Kudo
Radiology case reports, 17, 7, 2320, 2327, Jul. 2022, [International Magazine]
English, A 62-year-old woman presented with a tumor in the right kidney. A right partial nephrectomy was performed, and the tumor was diagnosed as clear cell renal cell carcinoma (RCC) on histopathological examination. A right ovarian tumor was detected on follow-up computed tomography (CT) 5 years after partial nephrectomy and pathology proved RCC metastasis. RCC rarely metastasizes to the ovaries. There is limited information on the radiological features of ovarian metastasis in RCC. In this case report, we presented the CT and magnetic resonance images of ovarian metastasis of RCC. In addition, we also presented a literature review with special emphasis on the imaging features of ovarian metastasis of RCC. - GRIK2 is a target for bladder cancer stem-like cell-targeting immunotherapy.
Haruka Miyata, Yoshihiko Hirohashi, Shuhei Yamada, Junko Yanagawa, Aiko Murai, Shinichi Hashimoto, Serina Tokita, Kanta Hori, Takashige Abe, Terufumi Kubo, Tomohide Tsukahara, Takayuki Kanaseki, Nobuo Shinohara, Toshihiko Torigoe
Cancer immunology, immunotherapy : CII, 71, 4, 795, 806, Apr. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Recent studies have revealed that treatment-resistant cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) can be targeted by cytotoxic T lymphocytes (CTLs). CTLs recognize antigenic peptides derived from tumor-associated antigens; thus, the identification of tumor-associated antigens expressed by CSCs/CICs is essential. Human leucocyte antigen (HLA) ligandome analysis using mass spectrometry enables the analysis of naturally expressed antigenic peptides; however, HLA ligandome analysis requires a large number of cells and is challenging for CSCs/CICs. In this study, we established a novel bladder CSC/CIC model from a bladder cancer cell line (UM-UC-3 cells) using an ALDEFLUOR assay. CSCs/CICs were isolated as aldehyde dehydrogenase (ALDH)-high cells and several ALDHhigh clone cells were established. ALDHhigh clone cells were enriched with CSCs/CICs by sphere formation and tumorigenicity in immunodeficient mice. HLA ligandome analysis and cap analysis of gene expression using ALDHhigh clone cells revealed a distinctive antigenic peptide repertoire in bladder CSCs/CICs, and we found that a glutamate receptor, ionotropic, kainite 2 (GRIK2)-derived antigenic peptide (LMYDAVHVV) was specifically expressed by CSCs/CICs. A GRIK2 peptide-specific CTL clone recognized GRIK2-overexpressing UM-UC-3 cells and ALDHhigh clone cells, indicating that GRIK2 peptide can be a novel target for bladder CSC/CIC-targeting immunotherapy. - 腎癌に対する免疫チェックポイント阻害薬併用療法により糖尿病ケトアシドーシスを発症し、その入院中にACTH分泌低下症を発症した1例
家坂 光, 亀田 啓, 宮 愛香, 野本 博司, ちょう 圭龍, 中村 昭伸, 安部 崇重, 篠原 信雄, 三好 秀明, 渥美 達也
日本内分泌学会雑誌, 97, 5, 1253, 1253, (一社)日本内分泌学会, Mar. 2022
Japanese - Favorable response to pembrolizumab in granulocyte colony-stimulating factor-producing upper urinary tract urothelial carcinoma.
Hiroki Takeda, Ryuji Matsumoto, Emi Takakuwa, Kanta Hori, Takuya Moriguchi, Shuhei Yamada, Hiroshi Kikuchi, Takahiro Osawa, Takashige Abe, Nobuo Shinohara
IJU case reports, 5, 2, 108, 112, Mar. 2022, [International Magazine]
English, INTRODUCTION: Granulocyte colony-stimulating factor-producing upper urinary tract urothelial carcinoma is rare, with a poor prognosis. Advanced urothelial carcinoma is currently treated with immune checkpoint inhibitors, whose efficacy for granulocyte colony-stimulating factor-producing upper urinary tract urothelial carcinoma remains unclear. CASE PRESENTATION: A 66-year-old male diagnosed with clinical stage T3N1M0 urothelial carcinoma of the right ureter with giant hydronephrosis underwent right radical nephroureterectomy. Local recurrence, leukocytosis, and elevated serum granulocyte colony-stimulating factor levels were observed approximately 3 months after surgery. Chemotherapy was started but failed to control the disease. Therefore, pembrolizumab was chosen as the second-line treatment. After this treatment, the blood leukocyte count rapidly normalized, and a clinically favorable response was achieved. There was no recurrence 10 months after the beginning of pembrolizumab treatment, which is still ongoing. CONCLUSION: Pembrolizumab may be a treatment option for advanced granulocyte colony-stimulating factor-producing upper urinary tract urothelial carcinoma. - Outcomes of bacillus Calmette-Guérin therapy without a maintenance schedule for high-risk non-muscle-invasive bladder cancer in the second transurethral resection era.
Hiroshi Kikuchi, Takashige Abe, Ryuji Matsumoto, Takahiro Osawa, Satoru Maruyama, Sachiyo Murai, Nobuo Shinohara
International journal of urology : official journal of the Japanese Urological Association, 29, 3, 251, 258, Mar. 2022, [International Magazine]
English, Scientific journal, OBJECTIVES: We examined the outcomes of eight weekly bacillus Calmette-Guérin induction therapy after second transurethral resection, and investigated risk factors for intravesical recurrence or disease progression in high-risk non-muscle-invasive bladder cancer patients. METHODS: This retrospective study included 146 high-risk non-muscle-invasive bladder cancer patients who received eight weekly bacillus Calmette-Guérin instillations without a maintenance schedule between 2000 and 2019. Intravesical recurrence-free and progression-free survival rates were evaluated using the Kaplan-Meier method. The Cox proportional hazards model was used to identify risk factors. RESULTS: Pathological T staging in the first transurethral resection was pTa in 56 patients (38.4%), pT1 in 75 (51.4%) and primary carcinoma in situ in 15 (10.2%). A total of 109 (83.2%) with pTa-1 disease underwent second transurethral resection before bacillus Calmette-Guérin induction therapy, and residual disease was detected in 54 (49.5%). The completion rate of eight instillations was 82.2%. The 2- and 5-year intravesical recurrence-free survival rates were 80.7% and 75.2%, whereas the 2- and 5-year progression-free survival rates were 85.7% and 82.0%. Recurrent tumors (hazard ratio 6.5830, P = 0.0007) and residual tumors at the second transurethral resection (hazard ratio 4.0337, P = 0.0021) were risk factors for intravesical recurrence. Multiple tumors (hazard ratio 5.8056, P = 0.0302), pT1 disease (hazard ratio 3.7351, P = 0.0447) and residual tumors at second transurethral resection (hazard ratio 3.2552, P = 0.0448) were associated with disease progression. CONCLUSIONS: Accurate disease staging and disease elimination by second transurethral resection followed by eight weekly bacillus Calmette-Guérin instillations achieved good disease control. Our protocol (without a maintenance schedule) after thorough surgical resection has potential as a treatment option in the current bacillus Calmette-Guérin shortage. - [Leukemia Relapse as Granulocytic Sarcoma Beginning with Penile Localization : A Case Report].
Shogo Aizawa, Takahiro Osawa, Hiroshi Kikuchi, Ryuji Matsumoto, Takashige Abe, Souichi Shiratori, Tomoko Mitsuhashi, Nobuo Shinohara
Hinyokika kiyo. Acta urologica Japonica, 68, 2, 63, 66, Feb. 2022, [Domestic magazines]
Japanese, Scientific journal, A 57-year-old man visited the urology department with a painful mass on the dorsal side of the penis. Magnetic resonance imaging sagittal image showed a small nodule. Leukemia recurrence was suspected due to his history of treatment for acute myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation. No recurrence was identified by bone marrow biopsy ; however, two months later, the recurrence of leukemia was strongly suspected because the tumor grew over time and blasts were found in the peripheral blood. A biopsy of the penile tumor and bone marrow was performed, leading to the diagnosis of granulocytic sarcoma. Patients with a history of leukemia may be preceded by a single recurrence to extramedullary organs, even if blood and bone marrow findings suggest remission. - [TREATMENT OF BLADDER UROTHELIAL CARCINOMA WITH LUNG METASTASIS AFTER RENAL TRANSPLANTATION].
Tatsu Tanabe, Takahiro Osawa, Kiyohiko Hotta, Daiki Iwami, Hiroshi Kikuchi, Ryuji Matsumoto, Takashige Abe, Nobuo Shinohara
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 113, 1, 37, 41, 2022, [Domestic magazines]
Japanese, Scientific journal, We report a case of bladder cancer in a 54-year-old woman who underwent renal transplantation for chronic renal failure. Six years after the transplantation, she was diagnosed with muscle-invasive bladder cancer with multiple lung metastases. She received gemcitabine/cisplatin therapy for Stage IV bladder cancer, and the dose of the immunosuppressants was reduced to prevent adverse effects. Since lung metastatic lesions disappeared after four courses of chemotherapy and no new lesions were found, we performed radical cystectomy and right nephroureterectomy with ileal conduit construction. Although she was followed closely without therapy, multiple lung metastases appeared 6 months after the radical cystectomy. Gemcitabine/carboplatin therapy was administered, and the lung metastasis improved slightly until the end of the 4th course, but aggressive growth was observed after the 5th course. She switched to palliative treatment without requesting additional treatment and died of cancer 1 year and 9 months after total cystectomy.There is no evidence-based treatment strategy for advanced bladder cancer after kidney transplantation. It is necessary to recognize that the patient had renal dysfunction and was in an immunosuppressed state. Thus, it is crucial to select appropriate drug and surgical treatments for each patient. - Quality improvement in managing patients with non-muscle-invasive bladder cancer by introducing a surgical checklist for transurethral resection of bladder tumor.
Hiroshi Kikuchi, Takahiro Osawa, Takashige Abe, Ryuji Matsumoto, Satoru Maruyama, Sachiyo Murai, Nobuo Shinohara
PloS one, 17, 10, e0276816, 2022, [International Magazine]
English, Scientific journal, BACKGROUND: The quality of transurethral resection of bladder tumor (TURBT) markedly varies among surgeons and may have a considerable impact on treatment outcomes. The importance of a surgical checklist for TURBT has been suggested in order to standardize the procedure and improve surgical and oncological outcomes. In the present study, we verified the usefulness of a checklist for managing patients with non-muscle-invasive bladder cancer (NMIBC). METHODS: This retrospective study included 201 NMIBC patients diagnosed with Ta, T1, or Tis between October 2011 and February 2021. After September 2016, TURBT was performed with a checklist. We analyzed the intravesical recurrence-free survival (RFS) rate and the presence or absence of the detrusor muscle in resected specimens before and after the introduction of the checklist. Survival rates were compared using the Log-rank test. A multivariate analysis with Cox proportional hazards modeling was performed to verify risk factors for intravesical recurrence. RESULTS: Ninety-nine patients who underwent TURBT with the checklist (checklist group) were compared with 102 patients who underwent TURBT without the checklist (non-checklist group). When the analysis was narrowed down to 9 critical items, we observed a mean number of 9 documented items per operative report (98.0% completion) after implementation of the checklist. Two-year intravesical RFS rates in the checklist and non-checklist groups were 76.7 and 69.5%, respectively (p = 0.1059). The Cox proportional multivariate analysis showed that the rate of intravesical recurrence was slightly lower in the checklist group (hazard ratio 0.7376, 95% CI 0.4064-1.3388, P = 0.3170). CONCLUSION: The introduction of a checklist is recommended for the standardization of TURBT and increasing the quality of operative reporting, and it may also improve oncological outcomes. - Primary renal leiomyosarcoma with a tumor thrombus in the inferior vena cava.
Mikio Konno, Takahiro Osawa, Kiyohiko Hotta, Ai Shimizu, Takashige Abe, Ryuji Matsumoto, Hiroshi Kikuchi, Nobuo Shinohara
IJU case reports, 5, 1, 66, 69, Jan. 2022, [International Magazine]
English, INTRODUCTION: We report a rare case of primary renal leiomyosarcoma with a tumor thrombus in the inferior vena cava. CASE PRESENTATION: A 54-year-old woman presented with right flank pain and abdominal distension. Physical examination findings were unremarkable. Abdominal computed tomography revealed a heterogeneously enhancing right solid renal mass with a thrombus in the renal vein extending into the inferior vena cava. Magnetic resonance imaging demonstrated a renal tumor with a thrombus about 4 cm below the hepatic vein. Chest computed tomography and bone scintigraphy were negative. The patient underwent right radical nephrectomy and vena cava thrombectomy. Histophathologic evaluation of the resected tumor confirmed the diagnosis of leiomyosarcoma. She underwent no adjuvant therapy. Seven months after surgery, the patient died following a 2-month history of multiple pulmonary and hepatic metastases. CONCLUSION: This report highlights the importance of considering the possibility of renal leiomyosarcoma invasion to the inferior vena cava, similar to renal cell carcinoma. - Validation of an online application to identify potential immune-related adverse events associated with immune checkpoint inhibitors based on the patient's symptoms.
Takahiro Osawa, Takashige Abe, Hiroshi Kikuchi, Ryuji Matsumoto, Sachiyo Murai, Takafumi Nakao, Shinji Tanaka, Ayu Watanabe, Nobuo Shinohara
PloS one, 17, 3, e0265230, 2022, [International Magazine]
English, Scientific journal, BACKGROUND: Immune checkpoint inhibitors (ICIs) are increasingly being used to treat malignancies. Some patients experience immune-related adverse events (irAEs), which may affect any organ/tissue. IrAEs are occasionally fatal and usually have nonspecific symptoms. We developed a three-step application (https://irae-search.com/) to provide healthcare professionals with information on the diagnosis, treatment options, and published reports for 38 categories of irAEs encountered in clinical practice. METHODS: IrAEs reported in ≥5 cases were identified from articles published between October 2018 and August 2020 by searching Japanese (SELIMIC, JAPIC-Q Service, and JMED Plus) and international (MEDLINE, EMBASE, Derwent Drug File) databases. The cases' symptoms were entered into the application to identify irAEs, which were verified using the reported diagnosis, to evaluate the application's sensitivity and specificity. RESULTS: Overall, 1209 cases (1067 reports) were analyzed. The three most common categories of irAEs were pituitary or adrenal disorders (14% of cases), skin disorders (13%), and diabetes mellitus (10%). The top three primary diseases were lung cancer (364 cases), melanoma (286 cases), and renal cell carcinoma (218 cases). The average sensitivity was 90.8% (range 44.4%-100.0%) initially, and improved to 94.8% (range 83.3%-100.0%) after incorporating the symptoms reported in published cases into the application's logic for two irAE categories. The average specificity was 79.3% (range 59.1% [thyroid disorders]-98.2% [arthritis]). CONCLUSION: irAE Search is an easy-to-use application designed to help healthcare professionals identify potential irAEs in ICI-treated patients in a timely manner to facilitate prompt management/treatment. The application showed high sensitivity and moderate-to-high specificity for detecting irAEs. - Comparative study of postoperative complications after radical cystectomy during the past two decades in Japan: Radical cystectomy remains associated with significant postoperative morbidities.
Shuhei Yamada, Takashige Abe, Ataru Sazawa, Hidenori Katano, Hidetaka Suzuki, Ichiro Takeuchi, Junji Ishizaki, Keita Minami, Ken Morita, Kunihiko Tsuchiya, Norikata Takada, Shintaro Maru, Shuhei Ishikawa, Soshu Sato, Takafumi Kawazu, Takanori Yamashita, Takenori Ono, Tango Mochizuki, Tomoshige Akino, Yoshihiro Sasaki, Yuichiro Shinno, Jun Furumido, Haruka Miyata, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Nobuo Shinohara
Urologic oncology, 40, 1, 11.e17-11.e25, Jan. 2022, [International Magazine]
English, Scientific journal, OBJECTIVES: During the past 2 decades, in order to improve perioperative and oncological outcomes, a minimally invasive approach, neoadjuvant chemotherapy (NAC), and an enhanced postoperative recovery program after surgery have been introduced into routine clinical practice of radical cystectomy (RC). Our aim was to examine the differences in clinical practice and postoperative complications after RC by comparing our previous and current cohorts. MATERIALS AND METHODS: A retrospective multi-institutional study. We collected all complications within 90 days after surgery between 2011 and 2017 (current cohort), and categorized them according to a standardized methodology. Then, we compared the outcomes with those in our previous study (previous cohort, 1997-2010). A multivariate logistic regression model was utilized to determine predictors of complications in the current cohort. RESULTS: A total of 838 patients were newly collected (current cohort), and 919 from the previous cohort were included in the subsequent analyses. In the current cohort, the rate of performing NAC was significantly higher (13% vs. 4%, respectively, P < 0.0001), and 26% (222/838) underwent laparoscopic RC (LRC, without robotic assistance: n = 210, with robotic assistance: n = 12). There was no significant difference in the overall complication [69% (580/838) vs. 68% (629/919), respectively, P = 0.7284] or major complication (Grades 3-5) [25% (211/838) vs. 22% (201/919), respectively, P = 0.1022] rates between the 2 cohorts. In both cohorts, the most frequent categories were infectious, gastrointestinal, wound-related, and genitourinary. In the current cohort, the performance status (odds ratio, OR = 2.11, P = 0.0013) and operative time (OR = 1.003, P = 0.0016) remained significant predictors of major complications. NAC was not associated with any or major complications. CONCLUSIONS: Surgical complications related to RC still remain significant problems, despite the recent improvements in surgical techniques and perioperative care. NAC did not increase the complications. - MONSTAR-SCREEN試験におけるリキッドバイオプシー研究
加藤 大悟, 松原 伸晃, 塩田 真己, 江藤 正俊, 大澤 崇宏, 安部 崇重, 篠原 信雄, 安水 洋太, 田中 伸之, 大家 基嗣, 西本 紘嗣郎, 林 拓自, 中山 雅志, 吉野 孝之, 野々村 祝夫
泌尿器科, 15, 1, 77, 82, (有)科学評論社, Jan. 2022
Japanese - MONSTAR-SCREEN試験におけるリキッドバイオプシー研究
加藤 大悟, 松原 伸晃, 塩田 真己, 江藤 正俊, 大澤 崇宏, 安部 崇重, 篠原 信雄, 安水 洋太, 田中 伸之, 大家 基嗣, 西本 紘嗣郎, 林 拓自, 中山 雅志, 吉野 孝之, 野々村 祝夫
泌尿器科, 15, 1, 77, 82, (有)科学評論社, Jan. 2022
Japanese - Efficacy of nivolumab plus ipilimumab as first-line therapy for primary tumors in patients with renal cell carcinoma.
Hiroshi Kikuchi, Takahiro Osawa, Ryuji Matsumoto, Takashige Abe, Satoru Maruyama, Toru Harabayashi, Haruka Miyata, Akira Kashiwagi, Suguru Ikeshiro, Ataru Sazawa, Riyo Fukui, Ken Morita, Ichiro Takeuchi, Kanta Hori, Noboru Yamashita, Keita Minami, Tango Mochizuki, Sachiyo Murai, Nobuo Shinohara
Urologic oncology, 40, 1, 13.e19-13.e27, Jan. 2022, [International Magazine]
English, Scientific journal, OBJECTIVES: With the emergence of several effective combination therapies, information on their effects at the primary site will be crucial for planning future cytoreductive nephrectomy (CN). The present study focused exclusively on changes in primary tumor sizes following treatment with nivolumab plus ipilimumab and investigated the clinical factors associated with a good response in primary tumors. METHODS AND MATERIALS: We retrospectively assessed 27 patients diagnosed with advanced renal cell carcinoma (RCC) who started treatment with nivolumab plus ipilimumab. Changes in tumor sizes at the primary site were described using waterfall and spider plots, respectively. We analyzed the correlation of tumor shrinkage between primary and metastatic site. The parameters analyzed between responders and non-responders according to primary tumor sizes were International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk scores, peripheral blood markers, and CRP. RESULTS: The median age and follow-up period were 66 years and 9.3 months, respectively. The median IMDC risk score was 3 (range: 1-6). Nineteen patients were diagnosed with clear-cell RCC (ccRCC) and 8 patients with non-ccRCC. Among ccRCC patients, 9 (47.4%) achieved a significant response with a maximum reduction of 30% or more in the size of the primary tumor from baseline within 4 months, while 3 (37.5%) out of 8 patients with non-ccRCC achieved a significant response. Shrinkage of the primary tumor correlated with the metastatic tumors in both ccRCC and non-ccRCC cases. Of note, 6 patients underwent CN and no viable tumor cells were detected in the surgical specimens of 3 patients whose primary tumors shrank by approximately 50%-60% with a reduction to 4 cm or less. Among ccRCC patients, the neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio were slightly lower in responders than in non-responders (P = 0.0944 and P = 0.0691). The platelet-to-lymphocyte ratio was significantly lower in responders than in non-responder (P = 0.0391). CONCLUSIONS: Significant responses in primary tumors to nivolumab plus ipilimumab were observed in 50% of ccRCC patients, while responses varied among non-ccRCC patients. Inflammation markers may be predictive factors of treatment responses in primary tumors. Although further studies are needed, the present results suggest the importance of considering CN from radiological and pathological viewpoints. - Automatic assessment of laparoscopic surgical skill competence based on motion metrics.
Koki Ebina, Takashige Abe, Kiyohiko Hotta, Madoka Higuchi, Jun Furumido, Naoya Iwahara, Masafumi Kon, Kou Miyaji, Sayaka Shibuya, Yan Lingbo, Shunsuke Komizunai, Yo Kurashima, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Teppei Tsujita, Kazuya Sase, Xiaoshuai Chen, Atsushi Konno, Nobuo Shinohara
PloS one, 17, 11, e0277105, 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, The purpose of this study was to characterize the motion features of surgical devices associated with laparoscopic surgical competency and build an automatic skill-credential system in porcine cadaver organ simulation training. Participants performed tissue dissection around the aorta, dividing vascular pedicles after applying Hem-o-lok (tissue dissection task) and parenchymal closure of the kidney (suturing task). Movements of surgical devices were tracked by a motion capture (Mocap) system, and Mocap-metrics were compared according to the level of surgical experience (experts: ≥50 laparoscopic surgeries, intermediates: 10-49, novices: 0-9), using the Kruskal-Wallis test and principal component analysis (PCA). Three machine-learning algorithms: support vector machine (SVM), PCA-SVM, and gradient boosting decision tree (GBDT), were utilized for discrimination of the surgical experience level. The accuracy of each model was evaluated by nested and repeated k-fold cross-validation. A total of 32 experts, 18 intermediates, and 20 novices participated in the present study. PCA revealed that efficiency-related metrics (e.g., path length) significantly contributed to PC 1 in both tasks. Regarding PC 2, speed-related metrics (e.g., velocity, acceleration, jerk) of right-hand devices largely contributed to the tissue dissection task, while those of left-hand devices did in the suturing task. Regarding the three-group discrimination, in the tissue dissection task, the GBDT method was superior to the other methods (median accuracy: 68.6%). In the suturing task, SVM and PCA-SVM methods were superior to the GBDT method (57.4 and 58.4%, respectively). Regarding the two-group discrimination (experts vs. intermediates/novices), the GBDT method resulted in a median accuracy of 72.9% in the tissue dissection task, and, in the suturing task, the PCA-SVM method resulted in a median accuracy of 69.2%. Overall, the mocap-based credential system using machine-learning classifiers provides a correct judgment rate of around 70% (two-group discrimination). Together with motion analysis and wet-lab training, simulation training could be a practical method for objectively assessing the surgical competence of trainees. - Procedural virtual reality simulation training for robotic surgery: a randomised controlled trial
Nicholas Raison, Patrick Harrison, Takashige Abe, Abdullatif Aydin, Kamran Ahmed, Prokar Dasgupta
Surgical Endoscopy, 35, 12, 6897, 6902, Springer, 01 Dec. 2021
English, Scientific journal - Postoperative thyroid storm after radical nephrectomy for renal cell carcinoma with inferior vena cava tumor thrombus.
Naoya Iwahara, Takashige Abe, So Nagai, Masanao Yoshino, Hitoshi Saito, Hiromi Okada, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Nobuo Shinohara
IJU case reports, 4, 5, 330, 332, Sep. 2021, [International Magazine]
English, Introduction: Thyroid storm is a rare life-threating condition. We report a case of thyroid storm after radical nephrectomy for renal cell carcinoma with inferior vena cava tumor thrombus. Case presentation: A 76-year-old man with a left renal tumor and tumor thrombus extending into the inferior vena cava underwent left radical nephrectomy and thrombectomy. After the surgery, his postoperative course rapidly deteriorated, including central nervous system disturbance, fever, tachycardia, congestive heart failure, and hepatic manifestation. Thyroid function test revealed perioperative hyperthyroidism. Corticosteroids and inorganic iodide improved his condition, suggesting that he developed thyroid storm after surgery. He was discharged 5 months after surgery and has been free from disease recurrence for more than 2 years. Conclusion: Thyroid storm after surgery is rare. However, this postoperative complication is important because it is fatal if not diagnosed and treated properly. - Impact of health-related quality of life on repeat protocol biopsy compliance on active surveillance for favorable prostate cancer: results from a prospective cohort in the PRIAS-JAPAN study.
Yoichiro Tohi, Takuma Kato, Akira Yokomizo, Koji Mitsuzuka, Ryotaro Tomida, Junichi Inokuchi, Ryuji Matsumoto, Toshihiro Saito, Hiroshi Sasaki, Koji Inoue, Hidefumi Kinoshita, Hiroshi Fukuhara, Satoru Maruyama, Shinichi Sakamoto, Toshiki Tanikawa, Shin Egawa, Haruhiko Ichikura, Takashige Abe, Masaki Nakamura, Yoshiyuki Kakehi, Mikio Sugimoto
Urologic oncology, 40, 2, 56.e9-56.e15, 08 Jun. 2021, [International Magazine]
English, Scientific journal, OBJECTIVES: This study aimed to evaluate how health-related quality of life (HRQOL) is related to repeat protocol biopsy compliance. MATERIALS AND METHODS: We conducted a retrospective analysis using data from a prospective cohort in the Prostate Cancer Research International: Active Surveillance (PRIAS)-JAPAN study between January 2010 and August 2019. We used the Short Form 8 Health Survey (SF-8), as patient-reported outcomes, to assess HRQOL at AS enrollment and the first year of the protocol. The physical component summary (PCS) and mental component summary (MCS) were calculated from SF-8 questionnaires. The primary outcome was the evaluation of the association of HRQOL at enrollment on the first repeat biopsy compliance. The secondary outcome was the comparison of SF-8 scores during AS, stratified by repeat protocol biopsy compliance. RESULTS: Of 805 patients who proceeded to the first year of the protocol, the non-compliance rate was 15% (121 patients). In the adjusted model, lower MCS at enrollment was significantly associated with the first repeat protocol biopsy non-compliance (odds ratio [OR], 2.134; 95% confidence interval [CI], 1.031-4.42; P = 0.041) but not in lower PCS (OR, 0.667; 95% CI, 0.294-1.514; P = 0.333). All subscales of SF-8 were lower in the non-compliance group than in the compliance group at any point. MCS in the non-compliance group improved over time from the time of AS enrollment (2.34 increased, P = 0.152). CONCLUSION: Our data suggest that lower MCS at AS enrollment using patient-reported outcomes was negatively associated with the first repeat protocol biopsy compliance. Our study may support the availability of a simple questionnaire to extract non-compliance. - Intravesical Bacillus Calmette-Guérin Treatment for T1 High-Grade Non-Muscle Invasive Bladder Cancer with Divergent Differentiation or Variant Morphologies.
Makito Miyake, Nobutaka Nishimura, Kota Iida, Tomomi Fujii, Ryoma Nishikawa, Shogo Teraoka, Atsushi Takenaka, Hiroshi Kikuchi, Takashige Abe, Nobuo Shinohara, Eijiro Okajima, Takuto Shimizu, Shunta Hori, Norihiko Tsuchiya, Takuya Owari, Yasukiyo Murakami, Rikiya Taoka, Takashi Kobayashi, Takahiro Kojima, Naotaka Nishiyama, Hiroshi Kitamura, Hiroyuki Nishiyama, Kiyohide Fujimoto
Cancers, 13, 11, 26 May 2021, [International Magazine]
English, Scientific journal, The 2016 World Health Organization classification newly described infiltrating urothelial carcinoma (UC) with divergent differentiation (DD) or variant morphologies (VMs). Data comparing oncological outcomes after bladder-preservation therapy using intravesical Bacillus Calmette-Guérin (BCG) treatment among T1 bladder pure UC (pUC), UC with DD (UC-DD), and UC with VMs (UC-VM) are limited. We evaluated 1490 patients with T1 high-grade bladder UC who received intravesical BCG during 2000-2019. They were classified into three groups: 93.6% with pUC, 4.4% with UC-DD, and 2.0% with UC-VM. Recurrence-free, progression-free, and cancer-specific survival following intravesical BCG were compared among the groups using multivariate Cox regression analysis, also used to estimate inverse probability of treatment weighting-adjusted hazard ratio and 95% confidence interval for the outcomes. Glandular differentiation and micropapillary variant were the most common forms in the UC-DD and UC-VM groups, respectively. Of 1490 patients, 31% and 13% experienced recurrence and progression, respectively, and 5.0% died of bladder cancer. Survival analyses revealed the impact of concomitant VMs was significant for cancer-specific survival, but not recurrence-free and progression-free survival compared with that of pUC. Our analysis clearly demonstrated that concomitant VMs were associated with aggressive behavior in contrast to concomitant DD in patients treated with intravesical BCG. - Effects of Repeated 131I-Meta-Iodobenzylguanidine Radiotherapy on Tumor Size and Tumor Metabolic Activity in Patients with Metastatic Neuroendocrine Tumors.
Keiichiro Yoshinaga, Takashige Abe, Shozo Okamoto, Yuko Uchiyama, Osamu Manabe, Yoichi M Ito, Naomi Tamura, Natsue Ito, Naho Yoshioka, Komei Washino, Nobuo Shinohara, Nagara Tamaki, Tohru Shiga
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 62, 5, 685, 694, 10 May 2021, [International Magazine]
English, Scientific journal, 131I-meta-iodobenzylguanidine (131I-MIBG) radiotherapy has shown some survival benefits in metastatic neuroendocrine tumors (NETs). European Association of Nuclear Medicine clinical guidelines for 131I-MIBG radiotherapy suggest a repeated treatment protocol, although none currently exists. The existing single-high-dose 131I-MIBG radiotherapy (444 MBq/kg) has been shown to have some benefits for patients with metastatic NETs. However, this protocol increases adverse effects and requires alternative therapeutic approaches. Therefore, the aim of this study was to evaluate the effects of repeated 131I-MIBG therapy on tumor size and tumor metabolic response in patients with metastatic NETs. Methods: Eleven patients with metastatic NETs (aged 49.2 ± 16.3 y) prospectively received repeated 5,550-MBq doses of 131I-MIBG therapy at 6-mo intervals. In total, 31 treatments were performed. The mean number of treatments was 2.8 ± 0.4, and the cumulative 131I-MIBG dose was 15,640.9 ± 2,245.1 MBq (286.01 MBq/kg). Tumor response was observed by CT and 18F-FDG PET or by 18F-FDG PET/CT before and 3-6 mo after the final 131I-MIBG treatment. Results: On the basis of the CT findings with RECIST, 3 patients showed a partial response and 6 patients showed stable disease. The remaining 2 patients showed progressive disease. Although there were 2 progressive-disease patients, analysis of all patients showed no increase in summed length diameter (median, 228.7 mm [interquartile range (IQR), 37.0-336.0 mm] to 171.0 mm [IQR, 38.0-270.0 mm]; P = 0.563). In tumor region-based analysis with partial-response and stable-disease patients (n = 9), 131I-MIBG therapy significantly reduced tumor diameter (79 lesions; median, 16 mm [IQR, 12-22 mm] to 11 mm [IQR, 6-16 mm]; P < 0.001). Among 5 patients with hypertension, there was a strong trend toward systolic blood pressure reduction (P = 0.058), and diastolic blood pressure was significantly reduced (P = 0.006). Conclusion: Eighty-two percent of metastatic NET patients effectively achieved inhibition of disease progression, with reduced tumor size and reduced metabolic activity, through repeated 131I-MIBG therapy. Therefore, this relatively short-term repeated 131I-MIBG treatment may have potential as one option in the therapeutic protocol for metastatic NETs. Larger prospective studies with control groups are warranted. - ウエットラボにおける腹腔鏡手術熟練課程の数値化の試み
安部 崇重, 海老名 光希, 樋口 まどか, 古御堂 純, 岩原 直也, 今 雅史, 堀田 紀世彦, 小水内 俊介, 倉島 庸, 村井 祥代, 近野 敦, 篠原 信雄
泌尿器外科, 34, 3, 327, 327, 医学図書出版(株), Mar. 2021
Japanese - Effect of Simulation-based Training on Surgical Proficiency and Patient Outcomes: A Randomised Controlled Clinical and Educational Trial
Abdullatif Aydın, Kamran Ahmed, Takashige Abe, Nicholas Raison, Mieke Van Hemelrijck, Hans Garmo, Hashim U. Ahmed, Furhan Mukhtar, Ahmed Al-Jabir, Oliver Brunckhorst, Nobuo Shinohara, Wei Zhu, Guohua Zeng, John P. Sfakianos, Mantu Gupta, Ashutosh Tewari, Ali Serdar Gözen, Jens Rassweiler, Andreas Skolarikos, Thomas Kunit, Thomas Knoll, Felix Moltzahn, George N. Thalmann, Andrea G. Lantz Powers, Ben H. Chew, Kemal Sarica, Muhammad Shamim Khan, Prokar Dasgupta, SIMULATE Trial Group
European Urology, Elsevier B.V., 2021
English, Scientific journal - 悪性リンパ腫の両側副腎転移により副腎不全を呈した1例
桑原 咲, 亀田 啓, 家坂 光, 泉原 里美, 大江 悠希, 上垣 里紗, 千葉 幸輝, 宮 愛華, 野本 博司, 曹 圭龍, 中村 昭伸, 安部 崇重, 篠原 信雄, 三好 秀明, 渥美 達也
日本内分泌学会雑誌, 96, 3, 598, 598, (一社)日本内分泌学会, Jan. 2021
Japanese - Are simple verbal instructions sufficient to ensure that bladder volume does not deteriorate prostate position reproducibility during spot scanning proton therapy?
Kentaro Nishioka, Kento Gotoh, Takayuki Hashimoto, Takashige Abe, Takahiro Osawa, Ryuji Matsumoto, Isao Yokota, Norio Katoh, Rumiko Kinoshita, Koichi Yasuda, Toshiaki Yakabe, Takaaki Yoshimura, Seishin Takao, Nobuo Shinohara, Hidefumi Aoyama, Shinichi Shimizu, Hiroki Shirato
BJR|Open, 3, 1, British Institute of Radiology, Jan. 2021, [Peer-reviewed]
Scientific journal,Objectives: The purpose of this study is to investigate whether verbal instructions are sufficient for bladder volume (BV) control not to deteriorate prostate position reproducibility in image-guided spot scanning proton therapy (SSPT) for localized prostate cancer.Methods: A total of 268 treatment sessions in 12 consecutive prostate cancer patients who were treated with image-guided SSPT with fiducial markers were retrospectively analyzed. In addition to strict rectal volume control procedures, simple verbal instructions to void urine one hour before the treatment were used here. The BV was measured by a Bladder Scan just before the treatment, and the prostate motion was measured by intraprostatic fiducial markers and two sets of X-ray fluoroscopy images. The correlation between the BV change and prostate motion was assessed by linear mixed-effects models and systematic and random errors according to the reproducibility of the BV.Results: The mean absolute BV change during treatment was from −98.7 to 86.3 ml (median 7.1 ml). The mean absolute prostate motion of the patients in the left-right direction was −1.46 to 1.85 mm; in the cranial-caudal direction it was −6.10 to 3.65 mm, and in the anteroposterior direction −1.90 to 5.23 mm. There was no significant relationship between the BV change and prostate motion during SSPT. The early and late genitourinary and gastrointestinal toxicity was minimal with a minimum follow up of 4.57 years.Conclusions: Simple verbal instructions about urination was suggested to be sufficient to control the BV not to impact on the prostate motion and clinical outcomes in image-guided SSPT. Careful attention to BV change is still needed when the seminal vesicle is to be treated.Advances in knowledge: Our data demonstrated that there was no apparent relationship between BV changes and prostate position reproducibility and simple verbal instruction about urination could be sufficient for image-guided SSPT. - Comparison of Health-Related Quality of Life Between Japanese and American Patients with Bladder Cancer as Measured by a Newly Developed Japanese Version of the Bladder Cancer Index
Takahiro Osawa, John T. Wei, Takashige Abe, Michitaka Honda, Karl T. Rew, Rod Dunn, Shuhei Yamada, Jun Furumido, Hiroshi Kikuchi, Ryuji Matsumoto, Yasuyuki Sato, Toni Harabayashi, Norikata Takada, Keita Minami, Ken Morita, Akira Kashiwagi, Shunichi Fukuhara, Sachiyo Murai, Yoichi M. Ito, Katsuhiko Ogasawara, Nobuo Shinohara
BLADDER CANCER, 7, 1, 61, 69, 2021
English, Scientific journal - モーションキャプチャー装置を用いた腹腔鏡手術手技の熟練過程の分析
安部 崇重, 海老名 光希, 樋口 まどか, 古御堂 純, 岩原 直也, 今 雅史, 堀田 記世彦, 小水内 俊介, 倉島 庸, 村井 祥代, 近野 敦, 篠原 信雄
日本泌尿器科学会総会, 108回, 899, 899, (一社)日本泌尿器科学会総会事務局, Dec. 2020
Japanese - Health-related quality of life in Japanese patients with bladder cancer measured by a newly developed Japanese version of the Bladder Cancer Index
Takahiro Osawa, John T. Wei, Takashige Abe, Michitaka Honda, Shuhei Yamada, Jun Furumido, Hiroshi Kikuchi, Ryuji Matsumoto, Kazushi Hirakawa, Yasuyuki Sato, Yoshihiro Sasaki, Toru Harabayashi, Norikata Takada, Keita Minami, Hiroshi Tanaka, Ken Morita, Akira Kashiwagi, Naoto Miyajima, Tomoshige Akino, Sachiyo Murai, Yoichi M. Ito, Shunichi Fukuhara, Katsuhiko Ogasawara, Nobuo Shinohara
International Journal of Clinical Oncology, 25, 12, 2090, 2098, Springer Science and Business Media LLC, Dec. 2020, [Peer-reviewed], [Domestic magazines]
English, Scientific journal,Abstract Introduction
We validated a Japanese version of the Bladder Cancer Index (BCI) as a tool for measuring health-related quality of life (HRQOL) in bladder cancer patients treated with various surgical procedures.Methods
The reliability and validity of the Japanese BCI were examined in 397 Japanese patients with bladder cancer via cross-sectional analysis. The patients simultaneously completed the Short Form (SF)-12, EQ-5D, and the Functional Assessment of Cancer Therapy-General and Bladder (FACT-G and FACT-BL). The differences in BCI subscales among various treatment groups were analyzed.Results
This study involved 397 patients (301 males and 96 females), with a mean age of 70 years and a median disease duration of 29 months (IQR: 12–66 months). Of these patients, 221 underwent transurethral resection of a bladder tumor, and 176 patients underwent radical cystectomy (ileal conduit: 101 patients, ileal neobladder: 49, and ureterostomy: 26). Cronbach’s alpha coefficient was ≥ 0.78 for all subscales, except the bowel bother subscale. Despite moderate correlations being detected between the function and bother score in urinary and bowel domains, the sexual function score was inversely correlated with the sexual bother score (r = − 0.19). A missing value percentage of > 15% was associated with old age (p < 0.05). The mean domain scores differed significantly among distinct clinically relevant treatment groups.Conclusions
Although revisions are needed to make it easier for elderly patients to comprehend, we confirmed the reliability and validity of the Japanese BCI. The Japanese BCI could be used for cross-cultural assessments of HRQOL in bladder cancer patients. - Motion analysis for better understanding of psychomotor skills in laparoscopy: objective assessment-based simulation training using animal organs.
Koki Ebina, Takashige Abe, Madoka Higuchi, Jun Furumido, Naoya Iwahara, Masafumi Kon, Kiyohiko Hotta, Shunsuke Komizunai, Yo Kurashima, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Teppei Tsujita, Kazuya Sase, Xiaoshuai Chen, Atsushi Konno, Nobuo Shinohara
Surgical endoscopy, 35, 8, 4399, 4416, 09 Sep. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal - Development and validation of a porcine organ model for training in essential laparoscopic surgical skills.
Madoka Higuchi, Takashige Abe, Kiyohiko Hotta, Ken Morita, Haruka Miyata, Jun Furumido, Naoya Iwahara, Masafumi Kon, Takahiro Osawa, Ryuji Matsumoto, Hiroshi Kikuchi, Yo Kurashima, Sachiyo Murai, Abdullatif Aydin, Nicholas Raison, Kamran Ahmed, Muhammad Shamim Khan, Prokar Dasgupta, Nobuo Shinohara
International journal of urology : official journal of the Japanese Urological Association, 03 Aug. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: To develop a wet laboratory training model for learning core laparoscopic surgical skills and evaluating learners' competency level outside the operating room. METHODS: Participants completed three tasks (task 1: tissue dissection around the aorta; task 2: tissue dissection and division of the renal artery; task 3: renal parenchymal closure). Each performance was video recorded and subsequently evaluated by two experts, according to the Global Operative Assessment of Laparoscopic Skills and task-specific metrics that we developed (Assessment Sheet of Laparoscopic Skills in Wet Lab score). Mean scores were used for analyses. The subjective mental workload was also assessed (NASA Task Load Index). RESULTS: The 54 participants included 32 urologists, eight young trainees and 14 medical students. A total of 13 participants were categorized as experts (≥50 laparoscopic surgeries), eight as intermediates (10-49) and 33 as novices (0-9). There were significant differences in the Global Operative Assessment of Laparoscopic Skills and Assessment Sheet of Laparoscopic Skills in Wet Lab scores among the three groups in all three tasks. Higher NASA Task Load Index scores were observed in novices, and there were significant differences in tasks 1 (Kruskal-Wallis test, P = 0.0004) and 2 (P = 0.0002), and marginal differences in task 3 (P = 0.0745) among the three groups. CONCLUSIONS: Our training model has good construct validity, and differences in the NASA Task Load Index score reflect previous laparoscopic surgical experiences. Our findings show the ability to assess both laparoscopic surgical skills and mental workloads, which could help educators comprehend trainees' level outside the operating room. Given the decreasing opportunity to carry out pure laparoscopic surgeries because of the dissemination of robotic surgery, especially in urology, our model can offer practical training opportunities. - 転移性腎癌に対するニボルマブとイピリムマブの併用療法により破壊性甲状腺炎に続いて劇症1型糖尿病を発症した1例
家坂 光, 亀田 啓, 安部 崇重, 亀田 玲奈, 宮 愛香, 野本 博司, 曹 圭龍, 中村 昭伸, 篠原 信雄, 三好 秀明, 渥美 達也
糖尿病, 63, Suppl.1, S, 173, (一社)日本糖尿病学会, Aug. 2020
Japanese - Development and validation of a measurement system for laparoscopic surgical procedures
Koki Ebina, Takashige Abe, Shunsuke Komizunai, Teppei Tsujita, Kazuya Sase, Xiaoshuai Chen, Madoka Higuchi, Jun Furumido, Naoya Iwahara, Yo Kurashima, Nobuo Shinohara, Atsushi Konno
SICE Journal of Control, Measurement, and System Integration, 13, 4, 191, 200, The Society of Instrument and Control Engineers, Jul. 2020, [Peer-reviewed], [Invited]
English, Scientific journal - Chemotherapy-induced IL-8 upregulates MDR1/ABCB1 in tumor blood vessels and results in unfavorable outcome
Hiroshi Kikuchi, Nako Maishi, Dorcas A. Annan, Mohammad Towfik Alam, Randa Ibrahim Hassan Dawood, Masumi Sato, Masahiro Morimoto, Ryo Takeda, Keita Ishizuka, Ryuji Matsumoto, Tomoshige Akino, Kunihiko Tsuchiya, Takashige Abe, Takahiro Osawa, Naoto Miyajima, Satoru Maruyama, Toru Harabayashi, Manabu Azuma, Katsushige Yamashiro, Kaname Ameda, Akira Kashiwagi, Yoshihiro Matsuno, Yasuhiro Hida, Nobu Shinohara, Kyoko Hida
Cancer Research, canres.3791.2019, canres.3791.2019, American Association for Cancer Research (AACR), 14 Jun. 2020, [Peer-reviewed]
English, Scientific journal - Erratum: Prognostic impact of local radiotherapy on metastatic urothelial carcinoma patients receiving systemic chemotherapy.
Takashige Abe, Keita Minami, Toru Harabayashi, Ataru Sazawa, Hiroki Chiba, Hiroshi Kikuchi, Haruka Miyata, Jun Frumido, Ryuji Matsumoto, Takahiro Osawa, Ishizaki Junji, Mochizuki Tango, Chiba Satoshi, Akino Tomoshige, Murakumo Masashi, Miyajima Naoto, Tsuchiya Kunihiko, Maruyama Satoru, Sachiyo Murai, Nobuo Shinohara
Japanese journal of clinical oncology, 50, 6, 727, 727, 10 Jun. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal - Oncologic outcomes of laparoscopic radical nephroureterectomy in conjunction with template-based lymph node dissection: An extended follow-up study.
Ryuji Matsumoto, Takashige Abe, Norikata Takada, Keita Minami, Toru Harabayashi, Satoshi Nagamori, Kanako C Hatanaka, Katsushige Yamashiro, Hiroshi Kikuchi, Takahiro Osawa, Satoru Maruyama, Nobuo Shinohara
Urologic oncology, 10 Jun. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: This study investigated the relapse pattern and oncologic outcomes after laparoscopic nephroureterectomy with template-based lymph node dissection (LND) in patients with clinically node-negative (cN0) upper urinary tract urothelial carcinoma. The frequency of lymph node metastasis, including micrometastases, was also evaluated. METHODS AND MATERIALS: A total of 105 patients with cTa-3N0M0 upper urinary tract urothelial carcinoma were analyzed, all of whom underwent regional LND during laparoscopic nephroureterectomy. Of those patients, 96 (91%) underwent complete LND in accordance with an anatomical template-based rule. We collected patient characteristics, pathological data, and follow-up data from medical charts. Micrometastases were assessed by pan-cytokeratin immunohistochemistry. Nonurothelial recurrence-free survival and cancer-specific survival were estimated using the Kaplan-Meier method. RESULTS: The median number of lymph nodes removed was 12 (range, 1-59). Lymph node metastasis was identified by routine pathological examination in 7 (7/105, 6.7%) patients. Pan-cytokeratin immunohistochemistry revealed micrometastases in 5 additional patients (pNmicro +: 5/105, 4.8%). Nonurothelial disease recurrence was observed in 21 (20%) patients at a median of 10 months (range: 1-33) after surgery. Distant metastasis was dominant (15/105, 14.3%), followed by locoregional recurrence (5/105, 4.8%) and both (1/105, 0.95%). The 5-year nonurothelial recurrence-free survival rates were 84.8% for pN0, 53.3% for pNmicro+, and 19.1% for pN+ (3-sample log-rank test, P < 0.0001). The 5-year cancer-specific survival rates were 95.0% for pN0, 53.3% for pNmicro+, and 23.8% for pN+ (P < 0.0001). CONCLUSIONS: Our observation showed that template-based LND could contribute to precise disease staging and better local disease control probably by eliminating nodal disease, compared with previous studies. The survival impact and ideal management of pNmicro+ disease should be evaluated in a larger cohort. - Virtually Competent: A Comparative Analysis of Virtual Reality and Dry-Lab Robotic Simulation Training
Nicholas Raison, Andrea Gavazzi, Takashige Abe, Kamran Ahmed, Prokar Dasgupta
Journal of Endourology, 34, 3, 379, 384, Mary Ann Liebert Inc., 01 Mar. 2020
English, Scientific journal - Abscopal effect following nivolumab induction in a patient with metastatic renal cell carcinoma-unique pathological features of the primary specimen: A case report.
Kanta Hori, Yoshihiko Hirohashi, Toshiki Aoyagi, Narumi Taniguchi, Masashi Murakumo, Haruka Miyata, Toshihiko Torigoe, Takashige Abe, Nobuo Shinohara, Ken Morita
Experimental and therapeutic medicine, 19, 3, 1903, 1907, Mar. 2020, [International Magazine]
English, Scientific journal, The case of a patient with metastatic renal cell carcinoma who exhibited the abscopal effect following treatment by anti-programmed death-1 (PD-1) antibody is presented. A 40-year-old woman was diagnosed with an 8.2-cm renal tumor without distant metastases, and radical nephrectomy was subsequently performed. Pathological examination revealed a clear cell renal cell carcinoma. At 3 months after surgery, the patient developed one lung metastasis. Following treatment with interferon and three types of tyrosine kinase inhibitors, anti-PD1 antibody (nivolumab) was started. During the treatment, para-aortic/supraclavicular lymph nodes and several lung lesions remained, although other lesions decreased markedly. The patient was subsequently treated by palliative radiotherapy to the para-aortic and supraclavicular lymph nodes for pain control. After the radiotherapy, the lung lesions previously refractory to nivolumab started to decrease, probably due to an abscopal effect. Additionally, the laboratory data and Karnofsky Performance Status improved. Histological re-examination of the primary lesion revealed heterogeneity of the immunological microenvironment, which may be associated with the heterogeneity of treatment sensitivity. - The updated outcomes of bladder-preserving trimodal therapy using a real-time tumor-tracking radiotherapy system for patients with muscle-invasive bladder cancer.
Haruka Miyata, Takahiro Osawa, Takashige Abe, Hiroshi Kikuchi, Ryuji Matsumoto, Satoru Maruyama, Kentaro Nishioka, Shinichi Shimizu, Takayuki Hashimoto, Hiroki Shirato, Nobuo Shinohara
Japanese journal of clinical oncology, 19 Jan. 2020, [Peer-reviewed], [International Magazine]
English, OBJECTIVE: Bladder-preserving trimodal therapy is recognized as a promising alternative treatment for muscle-invasive bladder cancer. We report the updated outcomes of muscle-invasive bladder cancer patients that were treated using our treatment protocol, which involves radiotherapy delivered with a real-time tumor-tracking radiotherapy system. METHODS: Thirty-eight patients who were diagnosed with T2-T4N0M0 bladder cancer between 1998 and 2016 and had clinically inoperable disease or refused to undergo surgery were enrolled. The treatment protocol included maximal transurethral resection followed by whole-bladder radiotherapy (40 Gy). Concurrent nedaplatin-based chemotherapy was administered to patients with adequate renal function. At the time of the first evaluation (via transurethral resection of the tumor bed), fiducial markers were endoscopically inserted into the bladder wall around the tumor. A boost of 25 Gy was administered using the real-time tumor-tracking radiotherapy system. The second evaluation (via transurethral resection of the tumor bed) was performed 6 months after the start of treatment. The Kaplan-Meier method and Cox hazards analysis were used to analyze overall survival and cancer-specific survival. RESULTS: The median duration of the follow-up period was 28 months (range: 3-161 months). The 5- and 10-year overall survival rates were 54.9 and 41.2%, respectively. Twenty-five (65.8%) and twenty (74.1%) patients had achieved complete responses to chemoradiation at the first and second evaluations, respectively. In univariate and multivariate analyses, performance status was found to be significantly associated with overall survival [P = 0.03, hazard ratio: 3.48, 95% confidence interval: 1.15-10.6] and cancer-specific survival [P = 0.02, hazard ratio: 4.57, 95% confidence interval: 1.32-16.9], and sex was shown to be significantly associated with cancer-specific survival [P = 0.03, hazard ratio: 3.07, 95% confidence interval: 1.09-8.30]. CONCLUSIONS: Our bladder-preserving trimodal therapy protocol, which involves the use of a real-time tumor-tracking radiotherapy system, produced an acceptable overall survival rate. This therapy is a reasonable alternative for patients that are medically unfit for or do not want to undergo cystectomy. - Validity assessment of the laparoscopic radical nephrectomy module of the LapVision virtual reality simulator.
Haruka Miyata, Takashige Abe, Kiyohiko Hotta, Madoka Higuchi, Takahiro Osawa, Ryuji Matsumoto, Hiroshi Kikuchi, Yo Kurashima, Sachiyo Murai, Nobuo Shinohara
Surgery open science, 2, 1, 51, 56, Jan. 2020, [International Magazine]
English, Scientific journal, Background: Virtual reality simulators allow trainees to perform repeated practice and provide objective dexterity metrics regarding their performance, which means that virtual reality-based surgical training is becoming a vital part of initial learning of basic laparoscopic surgical skills. However, its educational role in learning advanced procedures remains undetermined. We evaluated the validity of the laparoscopic radical nephrectomy module of the LapVision virtual reality simulator. Methods: Urologists, medical students, and a junior resident voluntarily participated in the present study, and they performed training with a laparoscopic left radical nephrectomy module. For construct validation, dexterity metrics calculated in the simulator and the mean score of Global Operative Assessment of Laparoscopic Skills evaluated by 2 experts' video review were compared according to the certification of Japanese Endoscopic Surgical Skill Qualification or previous surgical experience. Results: Ten experts (≥ 50 laparoscopic surgeries), 9 intermediates (11-49), and 14 novices (0-10) voluntarily participated in the present study. Regarding the construct validity, there was a significant difference in the total number of errors, blood loss, and Global Operative Assessment of Laparoscopic Skills score among the groups for both the Endoscopic Surgical Skill Qualification status and previous surgical experience. Conclusion: The present study demonstrated good construct validity for the LapVision nephrectomy module. Furthermore, global skill assessment was possible by experts' reviews, which indicates the usefulness of the virtual reality procedural module as a skill assessment tool. Virtual reality-based procedural simulation has marked potential to become a vital part of integrated laparoscopic training programs. - Retroperitoneal extragonadal germ cell tumor without distant metastasis: a case report.
Jun Furumido, Takahiro Osawa, Hiroshi Kikuchi, Ryuji Matsumoto, Takashige Abe, Emi Takakuwa, Nobuo Shinohara
International cancer conference journal, 9, 1, 5, 8, Jan. 2020, [Peer-reviewed], [International Magazine]
English, A 66-year-old man was referred to our hospital for an incidentally detected 40-mm mass located at the inter-aortocaval area around the renal hilum. Positron emission tomography CT revealed high accumulation (SUVmax 12.382) without distant metastasis. Bilateral testes were normal by ultrasonography and physical examination, but the serum AFP level was increased to 1161 ng/mL. The pathology based on trans-duodenal needle biopsy demonstrated a yolk sac tumor; therefore, we diagnosed him with retroperitoneal primary germ cell tumor. Due to old age, the potential toxicity of systemic chemotherapy, and no significant signs of invasion to adjacent organs, we performed surgical resection. Although the AFP level decreased to 13.2 ng/mL postoperatively, it increased to 553 ng/mL 2 months after surgery without clinical recurrence on imaging studies. Four cycles of a VIP regimen (VP-16, ifosfamide, and CDDP) were performed, and the AFP level normalized to 2.4 ng/mL. The patient is now disease-free 1 year and 6 months after surgery. - The urethral position may shift due to urethral catheter placement in the treatment planning for prostate radiation therapy.
Yasuhiro Dekura, Kentaro Nishioka, Takayuki Hashimoto, Naoki Miyamoto, Ryusuke Suzuki, Takaaki Yoshimura, Ryuji Matsumoto, Takahiro Osawa, Takashige Abe, Yoichi M Ito, Nobuo Shinohara, Hiroki Shirato, Shinichi Shimizu
Radiation oncology (London, England), 14, 1, 226, 226, 12 Dec. 2019, [Peer-reviewed], [International Magazine]
English, PURPOSE: To determine the best method to contour the planning organ at risk volume (PRV) for the urethra, this study aimed to investigate the displacement of a Foley catheter in the urethra with a soft and thin guide-wire. METHODS: For each patient, the study used two sets of computed tomography (CT) images for radiation treatment planning (RT-CT): (1) set with a Foley urethral catheter (4.0 mm diameter) plus a guide-wire (0.46 mm diameter) in the first RT-CT and (2) set with a guide-wire alone in the second CT recorded 2 min after the first RT-CT. Using three fiducial markers in the prostate for image fusion, the displacement between the catheter and the guide-wire in the prostatic urethra was calculated. In 155 consecutive patients treated between 2011 and 2017, 5531 slices of RT-CT were evaluated. RESULTS: Assuming that ≥3.0 mm of difference between the catheter and the guide-wire position was a significant displacement, the urethra with the catheter was displaced significantly from the urethra with the guide-wire alone in > 20% of the RT-CT slices in 23.2% (36/155) of the patients. The number of patients who showed ≥3.0 mm anterior displacement with the catheter in ≥20% RT-CT slices was significantly larger at the superior segment (38/155) than at the middle (14/155) and inferior segments (18/155) of the prostatic urethra (p < 0.0167). CONCLUSIONS: The urethral position with a Foley catheter is different from the urethral position with a thin and soft guide-wire in a significant proportion of the patients. This should be taken into account for the PRV of the urethra to ensure precise radiotherapy such as in urethra-sparing radiotherapy. - [The Development of the Preoperative Nomogram Predicting Major Perioperative Complications after Radical Cystectomy with Ileal Conduit or Orthotopic Neobladder].
Shuhei Yamada, Takahiro Osawa, Takashige Abe, Norikata Takada, Ryuji Matsumoto, YoichiM Ito, Hiroshi Kikuchi, Naoto Miyajima, Kunihiko Tsuchiya, Satoru Maruyama, Sachiyo Murai, Nobuo Shinohara
Hinyokika kiyo. Acta urologica Japonica, 65, 12, 495, 499, Dec. 2019, [Peer-reviewed], [Domestic magazines]
Japanese, Radical cystectomy (RC) is the gold standard for managing muscle-invasive and high-risknon-muscleinvasive bladder cancer, but is accompanied by non-negligible operative risk. The aim of this study is to identify preoperative variables to predict major perioperative complications after RC and to develop a nomogram using the cohort from multiple institutions in Japan. We retrospectively reviewed 668 patients who underwent open RC with ileal conduit or neobladder at Hokkaido University hospital and 20 affiliated institutions between 1997 and 2010. Complications occurring within 90 days of surgery were graded using modified Clavien classification system. We defined modified Clavien grade 3 or more as major complications and performed univariate and multivariate logistic regression analyses. Predictive accuracy of the nomogram was evaluated with the area under the receiver operating characteristics curve (AUC). A total of 528 men and 140 women were included in this study. There were a total of 160/668 patients (24%) with major perioperative complications. A multivariate model identified gender (OR : 1. 63, p=0. 04), cardiovascular comorbidity (OR : 1.48, p=0.03) and simultaneous nephroureterectomy (OR : 2.81, p=0. 01) as independent predictors. Using these 3 variables, a nomogram was developed with the AUC of 0.58. Predictive performance of our nomogram showed only fair performance ; but at least, we identified male, cardiovascular comorbidity and simultaneous nephroureterectomy as independent predictors of perioperative major complications. - Prognostic impact of local radiotherapy on metastatic urothelial carcinoma patients receiving systemic chemotherapy.
Takashige Abe, Keita Minami, Toru Harabayashi, Ataru Sazawa, Hiroki Chiba, Hiroshi Kikuchi, Haruka Miyata, Jun Frumido, Ryuji Matsumoto, Takahiro Osawa, Ishizaki Junji, Mochizuki Tango, Chiba Satoshi, Akino Tomoshige, Murakumo Masashi, Miyajima Naoto, Tsuchiya Kunihiko, Maruyama Satoru, Sachiyo Murai, Nobuo Shinohara
Japanese journal of clinical oncology, 28 Oct. 2019, [Peer-reviewed], [International Magazine]
English, OBJECTIVE: To clarify the prognostic impact of local radiotherapy on metastatic urothelial carcinoma patients treated by systemic chemotherapy. METHODS: Of the 228 metastatic urothelial carcinoma patients treated with systemic chemotherapy, 97 received radiotherapy mainly to metastatic sites. In patients for whom the purpose of radiotherapy was not specified, more than 50 Gy irradiation was considered to be for disease consolidation for survival analysis, while less than 50 Gy was categorized as palliation. According to the Kaplan-Meier method, we analysed overall survival from the initiation of treatment for metastatic urothelial carcinoma until death or the last follow-up, using the log-rank test to assess the significance of differences. The Cox model was applied for prognostic factor analysis. RESULTS: Overall, there was no significant difference in survival between patients with and those without radiotherapy (P = 0.1532). When analysing the patients undergoing consolidative radiotherapy separately, these 25 patients showed significantly longer survival than the 72 patients with palliative radiotherapy (P = 0.0047), with a 3-year overall survival of 43.3%. Of the present cohort, 22 underwent metastasectomy for disease consolidation, and there was no overlapping case between the metastasectomy cohort and cohort receiving consolidative radiotherapy. After controlling for four independent prognostic factors (sex, performance status, haemoglobin level and number of organs with metastasis) in our previous study, radiotherapy for disease consolidation showed a marginal value (hazard ratio = 0.666, P = 0.0966), while metastasectomy remained significant (hazard ratio = 0.358, P = 0.0006). CONCLUSIONS: In the selected patients, long-term disease control could be achieved after consolidative radiotherapy for metastatic urothelial carcinoma disease. Our observations suggest that local ablative therapy (surgery or radiotherapy) could facilitate long-term disease control. However, the treatment decision should be individualized because of the lack of randomized control trials. - Development of the Japanese version of the health-related quality of life questionnaire for bladder cancer patients using the Bladder Cancer Index: A pilot study.
Takahiro Osawa, John T Wei, Takashige Abe, Yuki Kako, Sachiyo Murai, Nobuo Shinohara
International journal of urology : official journal of the Japanese Urological Association, 26, 10, 1016, 1017, Oct. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal - The effect of repeated full immersion simulation training in ureterorenoscopy on mental workload of novice operators.
Abe T, Dar F, Amnattrakul P, Aydin A, Raison N, Shinohara N, Khan MS, Ahmed K, Dasgupta P
BMC medical education, 19, 1, 318, Aug. 2019, [Peer-reviewed] - Nephrometry score correlated with tumor proliferative activity inT1 clear cell renal cell carcinoma.
Hiroshi Kikuchi, Takashige Abe, Ryuji Matsumoto, Takahiro Osawa, Satoru Maruyama, Sachiyo Murai, Nobuo Shinohara
Urologic oncology, 37, 5, 301.e19-301.e25, 301.e25, May 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: To evaluate the association between the RENAL nephrometry score (RNS) and tumor proliferative activity assessed by immunohistochemistry in patients with localized renal cell carcinoma. METHODS: The current study included 145 pathological T1 (pT1) clear cell renal cell carcinomas (ccRCC). Tumor proliferative activity was assessed with the Ki67 index and microvessel density (MVD). RNS was retrospectively assessed in the present study. We divided patients into 3 groups according to RNS (RNS 4-6: low-complexity, 7-9: moderate complexity, and 10-12: high-complexity tumors) and compared the Ki67 index as well as MVD among the 3 groups. The association between the Ki67index/MVD and each component (R, E, N, A, L, h) was also evaluated. RESULTS: There were 56 low, 84 moderate, and 5 high-complexity tumors. The median Ki67 index of all tumors was 5.34% (interquartile range: 3.28-8.57). The median Ki67 index of low, moderate, and high-complexity tumors was 3.97%, 6.39%, and 11.27%, respectively, with a significant difference among the 3 groups (Kruskal-Wallis test, P = 0.0004). On the other hand, the median MVD of low, moderate, and high-complexity tumors was 14.11%, 14.42%, and 21.22%, respectively, and there were no significant differences among the 3 groups. In terms of each RNS component, there were significant differences in the Ki67 index among the 3 groups in N (P = 0.0101) and L (P = 0.0280) components, respectively. CONCLUSIONS: The revealed association between RNS and the Ki67 index in pT1 clear cell renal cell carcinomas further supports the previous findings that the anatomy of renal cell carcinoma is associated with the malignant potential of localized clear cell renal cell carcinoma, which may provide additional information for treatment decision. - A Measurement System for Skill Evaluation of Laparoscopic Surgical Procedures.
Koki Ebina, Takashige Abe, Shunsuke Komizunai, Teppei Tsujita, Kazuya Sase, XiaoShuai Chen, Madoka Higuchi, Jun Furumido, Naoya Iwahara, Yo Kurashima, Nobuo Shinohara, Atsushi Konno
58th Annual Conference of the Society of Instrument and Control Engineers of Japan, SICE 2019, Hiroshima, Japan, September 10-13, 2019, 1099, 1106, IEEE, 2019, [Peer-reviewed]
English, International conference proceedings - Cognitive training for technical and non-technical skills in robotic surgery: a randomised controlled trial.
Raison N, Ahmed K, Abe T, Brunckhorst O, Novara G, Buffi N, McIlhenny C, van der Poel H, van Hemelrijck M, Gavazzi A, Dasgupta P
BJU international, 122, 6, 1075, 1081, Dec. 2018, [Peer-reviewed] - Comparative study of lymph node dissection, and oncological outcomes of laparoscopic and open radical nephroureterectomy for patients with urothelial carcinoma of the upper urinary tract undergoing regional lymph node dissection.
Takashige Abe, Tsunenori Kondo, Toru Harabayashi, Norikata Takada, Ryuji Matsumoto, Takahiro Osawa, Keita Minami, Satoshi Nagamori, Satoru Maruyama, Sachiyo Murai, Kazunari Tanabe, Nobuo Shinohara
Japanese journal of clinical oncology, 48, 11, 1001, 1011, 01 Nov. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, Objective: To assess the number of lymph nodes removed as a surrogate marker of the extent of lymph node dissection, and compare survival outcomes between laparoscopic radical nephroureterectomy (LRNU) and open radical nephroureterectomy (ORNU) in patients undergoing standardized lymph node dissection. Methods: We retrospectively analyzed the data of 214 cTanyN0M0 patients undergoing radical NU with regional lymph node dissection according to the tumor location. The Kaplan-Meier method and Cox hazards model were utilized for survival analyses, including recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS). Results: A total of 114 patients underwent LRNU and 100 underwent ORNU. There was no significant difference in the pT stage, pN stage, or tumor grade, but distal ureteral tumors were more frequent in the LRNU group. The number of lymph nodes removed did not differ between the two groups [LRNU: 12 (median), ORNU: 11.5, P = 0.3852]. Lymph node metastasis was pathologically identified in 19 patients (8.9%). The 5-year RFS (ORNU: 71.7%, LRNU: 74%, P = 0.7829), CSS (77.8 and, 80%, P = 0.8441) and OS (72.8, and 75.9%, P = 0.3456) did not differ between the two groups. In the sub-analysis of pT3/4 patients (n = 83), there were no significant differences in RFS, CSS, or OS between the two groups, although Kaplan-Meier survival curves were slightly better for those receiving ORNU. In the multivariate model, LRNU was not significantly correlated with a poorer RFS, CSS or OS. Conclusion: Our data support the feasibility of lymph node dissection with a laparoscopic approach and the equivalent oncological outcome of LRNU compared with ORNU when regional lymph node dissection is performed. However, LRNU should be performed after careful patient selection for advanced disease. - Determination of the urethra position for accurate radiation therapy of prostate cancers
Dekura Yasuhiro, Nishioka Kentaro, Hashimoto Takayuki, Miyamoto Naoki, Suzuki Ryusuke, Matsumoto Ryuji, Osawa Takahiro, Abe Takashige, Maruyama Satoru, Shinohara Nobuo, Shirato Hiroki, Shimizu Shinichi
INTERNATIONAL JOURNAL OF UROLOGY, 25, 445, 445, Oct. 2018, [Peer-reviewed]
English - Outcome of maintenance systemic chemotherapy with drug-free interval for metastatic urothelial carcinoma
Abe Takashige, Ishizaki Junji, Minami Keita, Harabayashi Toru, Sazawa Ataru, Mochizuki Tango, Akino Tomoshige, Chiba Satoshi, Chiba Hiroshi, Murakumo Masashi, Matsumoto Ryuji, Shinohara Nobuo
INTERNATIONAL JOURNAL OF UROLOGY, 25, 200, Oct. 2018, [Peer-reviewed] - Long-term Outcomes of Tri-modality Therapy using a real-time tumor-tracking radiotherapy system for Patients with Muscle-invasive Bladder Cancer
Miyata Haruka, Osawa Takahiro, Matsumoto Ryuji, Abe Takashige, Maruyama Satoru, Nishioka Kentaro, Shimizu Shinichi, Hashimoto Takayuki, Shirato Hiroki, Shinohara Nobuo
INTERNATIONAL JOURNAL OF UROLOGY, 25, 321, Oct. 2018, [Peer-reviewed] - Has Segmental Ureterectomy Now Become an Alternative Treatment to Radical Nephroureterectomy?
Abe T
Journal of investigative surgery : the official journal of the Academy of Surgical Research, 1, Oct. 2018, [Peer-reviewed] - [Urinary Retention Caused by Necrotic Tissues in the Bladder of a Female Recipient of a Living-Donor Kidney Transplant : A Case Report].
Muranishi Y, Fukuzawa N, Wada Y, Abe T, Shinohara N, Harada H
Hinyokika kiyo. Acta urologica Japonica, 64, 10, 409, 413, Oct. 2018, [Peer-reviewed] - [Treatment Outcome of Axitinib for Metastatic Renal-Cell Carcinoma Patients].
Naohisa Kusakabe, Takahiro Osawa, Haruka Miyata, Hiroshi Kikuchi, Ryuji Matsumoto, Satoru Maruyama, Takashige Abe, Nobuo Shinohara
Hinyokika kiyo. Acta urologica Japonica, 64, 9, 353, 358, Sep. 2018, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, Axitinib was approved for use in Japan as a salvage therapy for patients with metastatic renal cell carcinoma (RCC) in 2012. We retrospectively evaluated the cases of 32 RCC patients that were treated with Axitinib as a 2nd- or further-line therapy between November 2012 and March 2017. Overall survival (OS), progression-free survival (PFS), and adverse events were assessed. The median OS and PFS from the initiation of Axitinib were 29 and 11 months, respectively. Nineteen patients received Axitinib as a 2nd-line treatment, in whom the median OS and median PFS were 22 and 10 months, respectively, while the median OS and PFS were 29 and 15.5 months, respectively, amongthe 13 patients who received Axitinib as a 3rd- or further-line treatment, which suggested that Axitinib is effective in the 3rd-line and further-line settings. A Cox multivariate model revealed that bone metastasis was a significant adverse factor for OS. Common grade 3 or higher adverse events included hypertension (28%), diarrhea (7%), and proteinuria (7%). Although the present study demonstrated the efficacy and safety of salvage Axitinib treatment in patients who had recurrent disease after the initial systemic therapy, further large-scale studies should be warranted to make clear its clinical effectiveness in these patients. - Outcome and prognostic factors in metastatic urothelial carcinoma patients receiving second-line chemotherapy: an analysis of real-world clinical practice data in Japan.
Ryuji Matsumoto, Takashige Abe, Junji Ishizaki, Hiroshi Kikuchi, Toru Harabayashi, Keita Minami, Ataru Sazawa, Tango Mochizuki, Tomoshige Akino, Masashi Murakumo, Takahiro Osawa, Satoru Maruyama, Sachiyo Murai, Nobuo Shinohara
Japanese journal of clinical oncology, 48, 8, 771, 776, 01 Aug. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, Objectives: The objective of the present study was to investigate the survival outcome and prognostic factors of metastatic urothelial carcinoma patients treated with second-line systemic chemotherapy in real-world clinical practice. Methods: Overall, 114 patients with metastatic urothelial carcinoma undergoing second-line systemic chemotherapy were included in this retrospective analysis. The dominant second-line chemotherapy was a paclitaxel-based combination regimen (60%, 68/114). We assessed the progression-free survival and overall survival times using the Kaplan-Meier method. The Cox proportional hazards model was applied to identify the factors affecting overall survival. Results: The median progression-free survival and overall survival times were 4 and 9 months, respectively. In the multivariate analysis, an Eastern Cooperative Oncology Group performance status score greater than 0 at presentation, C-reactive protein level ≧1 mg/dl and poor response to prior chemotherapy were adverse prognostic indicators. Patients with 0, 1, 2 and 3 of those risk factors had a median overall survival of 17, 12, 7 and 3 months, respectively. Conclusions: The Eastern Cooperative Oncology Group performance status at presentation, C-reactive protein level and response to prior chemotherapy were prognostic factors for metastatic urothelial carcinoma patients undergoing second-line chemotherapy. In the future, this information might help guide the choice of salvage treatment, such as second-line chemotherapy or immune checkpoint inhibitors, after the failure of first-line chemotherapy. - Validation of the nomogram for predicting 90-day mortality after radical cystectomy in a Japanese cohort.
Osawa T, Abe T, Takada N, Ito YM, Murai S, Shinohara N
International journal of urology : official journal of the Japanese Urological Association, 25, 7, 699, 700, Jul. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal - The Validation of a Novel Robot-Assisted Radical Prostatectomy Virtual Reality Module
Patrick Harrison, Nicholas Raison, Takashige Abe, William Watkinson, Faizan Dar, Ben Challacombe, Henk Van Der Poel, Muhammad Shamim Khan, Prokar Dasgupa, Kamran Ahmed
Journal of Surgical Education, 75, 3, 758, 766, Elsevier Inc., 01 May 2018, [Peer-reviewed]
English, Scientific journal - Establishing objective benchmarks in robotic virtual reality simulation at the level of a competent surgeon using the RobotiX Mentor simulator.
Watkinson W, Raison N, Abe T, Harrison P, Khan S, Van der Poel H, Dasgupta P, Ahmed K
Postgraduate medical journal, 94, 1111, 270, 277, May 2018, [Peer-reviewed] - OUTCOME OF REGIONAL LYMPH NODE DISSECTION IN PATIENTS WITH CLINICAL NODE-NEGATIVE UROTHELIAL CARCINOMA OF THE UPPER URINARY TRACT: CHARACTERISTICS OF MICROMETASTASIS
Matsumoto Ryuji, Abe Takashige, Takada Norikata, Minami Keita, Harabayashi Toru, Kikuchi Hiroshi, Osawa Takahiro, Maruyama Satoru, Shinohara Nobuo
JOURNAL OF UROLOGY, 199, 4, E220, Apr. 2018, [Peer-reviewed] - THE MODIFIED GLASGOW PROGNOSTIC SCORE IS A POWERFUL PROGNOSTIC FACTOR IN METASTATIC UROTHELIAL CARCINOMA PATIENTS RECEIVING SECOND-LINE CHEMOTHERAPY
Matsumoto Ryuji, Abe Takashige, Ishizaki Junji, Minami Keita, Harabayashi Toru, Sazawa Ataru, Mochizuki Tango, Akino Tomoshige, Murakumo Masashi, Miyajima Naoto, Tsuchiya Kunihiko, Kikuchi Hiroshi, Miyata Haruka, Osawa Takahiro, Maruyama Satoru, Murai Sachiyo, Shinohara Nobuo
JOURNAL OF UROLOGY, 199, 4, E1045, Apr. 2018, [Peer-reviewed] - OUTCOME OF MAINTENANCE SYSTEMIC CHEMOTHERAPY WITH DRUG-FREE INTERVAL FOR METASTATIC UROTHELIAL CARCINOMA
Abe Takashige, Ishizaki Junji, Minami Keita, Harabayashi Toru, Sazawa Ataru, Mochizuki Tango, Chiba Satoshi, Chiba Hiroki, Akino Tomoshige, Murakumo Masashi, Miyajima Naoto, Tsuchiya Kunihiko, Kikuchi Hiroshi, Miyata Haruka, Matsumoto Ryuji, Osawa Takahiro, Maruyama Satoru, Murai Sachiyo, Shinohara Nobuo
JOURNAL OF UROLOGY, 199, 4, E1042, Apr. 2018, [Peer-reviewed] - The Effect of Visual-Spatial Ability on the Learning of Robot-Assisted Surgical Skills
Takashige Abe, Nicholas Raison, Nobuo Shinohara, M. Shamim Khan, Kamran Ahmed, Prokar Dasgupta
Journal of Surgical Education, 75, 2, 458, 464, Elsevier Inc., 01 Mar. 2018, [Peer-reviewed]
English, Scientific journal - Analysis of multidrug resistant transporter expression in tumor blood vessels during chemotherapy
Maishi Nako, Kikuchi Hiroshi, Morimoto Hirofumi, Tsuchiya Kunihiko, Abe Takashige, Hida Yasuhiro, Harabayashi Toru, Matsuno Yoshihiro, Shinohara Nobuo, Hida Kyoko
CANCER SCIENCE, 109, 873, Jan. 2018, [Peer-reviewed] - Simulation training in upper tract endourology: myth or reality?
Lovegrove CE, Abe T, Aydin A, Veneziano D, Sarica K, Khan MS, Dasgupta P, Ahmed K
Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 69, 6, 579, 588, Dec. 2017, [Peer-reviewed] - Development and validation of a tool for non-technical skills evaluation in robotic surgery-the ICARS system
Nicholas Raison, Thomas Wood, Oliver Brunckhorst, Takashige Abe, Talisa Ross, Ben Challacombe, Mohammed Shamim Khan, Giacomo Novara, Nicolo Buffi, Henk Van Der Poel, Craig McIlhenny, Prokar Dasgupta, Kamran Ahmed
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 31, 12, 5403, 5410, Dec. 2017, [Peer-reviewed]
English, Scientific journal - Validation of the Advanced Scope Trainer for Flexible Ureterorenoscopy Training
Ahmed Al-Jabir, Abdullatif Aydin, Takashige Abe, Nicholas Raison, M. Shamim Khan, Prokar Dasgupta, Kamran Ahmed
UROLOGY, 110, 45, 50, Dec. 2017, [Peer-reviewed]
English, Scientific journal - Characteristics of Medical Adverse Events/Near Misses Associated With Laparoscopic/Thoracoscopic Surgery: A Retrospective Study Based on the Japanese National Database of Medical Adverse Events.
Abe T, Murai S, Nasuhara Y, Shinohara N
Journal of patient safety, 15, 4, 343, 351, Sep. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: The aim of this study was to clarify the characteristics of adverse events/near misses during laparoscopic/thoracoscopic surgery. METHODS: Using relevant key words for minimally invasive surgeries, 540 records were identified in the database of the Japan Council for Quality Health Care. After data review and the classification of adverse events, 746 events associated with laparoscopic (laparo group) and/or thoracoscopic (thoraco group) surgery were identified. We calculated the frequency of each event, compared the frequency regarding recurrent events, and evaluated the types of event that had resulted in deaths between the 2 groups. RESULTS: There were 582 events in the laparo group, 159 in the thoraco group, and 5 in those undergoing combined surgery. Overall, injury of other organs (11.4%, 85/746), retention of a foreign body (9.1%, 68/746), breakage/failure of medical equipment or devices (6.2%, 46/746), massive bleeding (5.9%, 44/746), misperception of anatomy (5.6%, 42/746), and vascular injury (4.8%, 36/746) were frequently reported. There were marked differences in the frequency of injury of other organs (laparo group: 13.4%, 78/582; thoraco group: 4.4%, 7/159), massive bleeding (laparo group: 3.4%, 20/582; thoraco group: 14.5%, 23/159), and vascular injury (laparo group: 2.6%, 15/582; thoraco group: 12.6%, 20/159) between the 2 groups. Among the 56 patient-death reports, 132 adverse events were identified. In the thoraco group, bleeding events were frequently observed, whereas in the laparo group, various categories of events were noted. CONCLUSIONS: We observed recurrent incidents and differences in the frequency between the 2 groups. Surgeons should keep in mind these characteristics. Retention of a foreign body and the breakage/malfunctioning of instruments might be reduced by the introduction of specialized checklists. - Perioperative morbidity and mortality of octogenarians treated by radical cystectomy-a multi-institutional retrospective study in Japan.
Takashige Abe, Norikata Takada, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Naoto Miyajima, Satoru Maruyama, Nobuo Shinohara
Japanese journal of clinical oncology, 47, 8, 755, 761, 01 Aug. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, Objective: To determine the characteristics of 90-day morbidity and mortality after radical cystectomy in Japanese octogenarians. Methods: A retrospective multi-institutional study. We reviewed the records of 834 patients treated by open radical cystectomy between 1997 and 2010. All complications within 90 days after surgery were sorted into the 11 categories proposed by the Memorial Sloan-Kettering Cancer Center and graded according to the modified Clavien-Dindo system. We compared the characteristics of complications between ≥80-year (n = 86) and <80-year (n = 748) groups. Multivariate regression models were used to determine the predictors of complications. Results: American Society of Anesthesiologists score III-IV was more frequent (14% vs. 6%, respectively, P < 0.0001), and ureterocutaneostomy was more frequently performed (30% vs. 21%, respectively, P = 0.0148) in the ≥80-year group compared with <80-year group. There were no significant differences in the rates of any complication, major (Grade 3-5) complication, or 90-day mortality between the two groups (≥80-year group: 70%, 21%, 3.5%, respectively, <80-year group: 68%, 22%, 2%, respectively). The ≥80-year group had fewer genitourinary complications (7% vs. 16%, respectively, P = 0.0131). Multivariate regression analyses revealed that bowel-using urinary diversion (P = 0.0031) and the operative time (P = 0.0269) were significant predictors of any grade of complications, and a male sex (P = 0.0167), annual cystectomy volume (P = 0.0284) and prior cardiovascular comorbidity (P = 0.0034) were significant predictors of major complications. Conclusions: In our experience, radical cystectomy in Japanese octogenarians caused similar perioperative comorbidities. Old age as a single criterion should not be used to abandon radical cystectomy; careful preoperative assessment is mandatory. - Analysis of multidrug resistant transporter expression in tumor blood vessels of urothelial carcinoma during chemotherapy.
Kikuchi Hiroshi, Maishi Nako, Akiyama Kosuke, Morimoto Masahiro, Yanagiya Misa, Miyajima Naoto, Tsuchiya Kunihiko, Maruyama Satoshi, Abe Takashige, Hida Yasuhiro, Harabayashi Toru, Ameda Kaname, Matsumoto Ryuji, Kashiwagi Akira, Matsuno Yoshihiro, Shinohara Nobuo, Hida Kyoko
JOURNAL OF CLINICAL ONCOLOGY, 35, 20 May 2017, [Peer-reviewed] - COMPARATIVE STUDY OF ONCOLOGICAL OUTCOMES OF LAPAROSCOPIC AND OPEN RADICAL NEPHROURETERECTOMY FOR PATIENTS WITH UROTHELIAL CARCINOMA OF THE UPPER URINARY TRACT UNDERGOING REGIONAL LYMPH NODE DISSECTION
Takashige Abe, Tsunenori Kondo, Toru Harabayashi, Norikata Takada, Ryuji Matsumoto, Ataru Sazawa, Takahiro Osawa, Keita Minami, Satoshi Nagamori, Naoto Miyajima, Kunihiko Tsuchiya, Satoru Maruyama, Sachiyo Murai, Kazunari Tanabe, Nobuo Shinohara
JOURNAL OF UROLOGY, 197, 4, E952, E952, Apr. 2017, [Peer-reviewed]
English - Radical prostatectomy restores detrusor contraction pattern according to pressure flow parameters
Takeya Kitta, Yukiko Kanno, Hiroki Chiba, Kimihiko Moriya, Satoru Maruyama, Takashige Abe, Nobuo Shinohara
INTERNATIONAL JOURNAL OF UROLOGY, 24, 4, 301, 307, Apr. 2017, [Peer-reviewed]
English, Scientific journal - Analysis of inter- and intra fractional partial bladder wall movement using implanted fiducial markers
Kentaro Nishioka, Shinichi Shimizu, Nobuo Shinohara, Yoichi M. Ito, Takashige Abe, Satoru Maruyama, Norio Katoh, Rumiko Kinoshita, Takayuki Hashimoto, Naoki Miyamoto, Rikiya Onimaru, Hiroki Shirato
RADIATION ONCOLOGY, 12, 1, 44, Mar. 2017, [Peer-reviewed]
English, Scientific journal - Outcome of metastatic urothelial carcinoma treated by systemic chemotherapy: Prognostic factors based on real-world clinical practice in Japan.
Takashige Abe, Junji Ishizaki, Hiroshi Kikuchi, Keita Minami, Ryuji Matsumoto, Toru Harabayashi, Ataru Sazawa, Tango Mochizuki, Satoshi Chiba, Tomoshige Akino, Masashi Murakumo, Naoto Miyajima, Kunihiko Tsuchiya, Satoru Maruyama, Sachiyo Murai, Nobuo Shinohara
Urologic oncology, 35, 2, 38.e1-38.e8, 38.e8, Feb. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, AIM: To clarify prognostic factors of metatstatic urothelial carcinoma treated by systemic chemotherapy in real-world clinical practice in the Japanese population. MATERIALS AND METHODS: A total of 228 patients with metastatic urothelial carcinoma undergoing systemic chemotherapy between 2000 and 2013 were included in the present multi-institutional study. The gemcitabine plus cisplatin regimen was administered as first-line chemotherapy to 131 patients, whereas methotrexate, vinblastine, doxorubicin, and cisplatin or its modified regimen was given to 71 patients. Of the 228 patients, 119 received at least 2 different regimens and 22 underwent resection of metastases (metastasectomy). Multivariate survival analysis was performed using the Cox proportional hazards model. The characteristics included were age, sex, Eastern Cooperative Oncology Group performance status (PS), primary site, pathology of primary site, hemoglobin levels, lactate dehydrogenase levels, C-reactive protein levels, corrected calcium levels, estimated glomerular filtration rate levels, history of prior chemotherapy, metastatic sites, resection of primary site, number of metastatic organs, and metastasectomy. RESULTS: The median overall survival (OS) time was 17 months. On multivariate analysis, female sex, good Eastern Cooperative Oncology Group PS at presentation, hemoglobin level≥10g/dl, and single organ metastasis were significant independent predictors of prolonged OS. For the survival effect of metastasectomy, the median OS time of the 22 patients with metastasectomy was 53 months, which was significantly longer when compared with patients not undergoing metastasectomy (15mo). After adjustment for the 4 aforementioned prognostic factors, metastasectomy still remained significant (hazard ratio: 0.364, P = 0.0008). CONCLUSIONS: Female sex, more favorable PS at presentation, hemoglobin level>10g/dl, and single organ metastasis were favorable prognostic factors. In addition, metastasectomy was associated with long-term disease control. - Editorial Comment to Use of sigmoid colon in orthotopic neobladder reconstruction: Long-term results
Takashige Abe
INTERNATIONAL JOURNAL OF UROLOGY, 23, 12, 990, 990, Dec. 2016, [Peer-reviewed]
English - Role of surgical consolidation in metastatic urothelial carcinoma.
Takashige Abe, Ryuji Matsumoto, Nobuo Shinohara
Current opinion in urology, 26, 6, 573, 80, Nov. 2016, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE OF REVIEW: Since the development of systemic combination chemotherapy, postchemotherapy extirpation has been performed in selected patients mainly with locally advanced and/or initially unresectable bladder cancer, and, in very selected patients, surgical consolidation for visceral metastases has also been performed. The purpose of this article was to review and summarize the current evidence for the role of surgical consolidation in metastatic urothelial carcinoma. RECENT FINDINGS: The role of metastasectomy has not yet been examined in a randomized setting. In terms of locally advanced and/or node-positive bladder cancer, studies further support the benefit of surgical consolidation, especially after a favorable response to systemic chemotherapy. Regarding metastasectomy for visceral metastasis, recent evidence suggested that lung metastases (ideally small solitary lesions) are a good indication. SUMMARY: Patients with a good response to chemotherapy, limited nodal/pulmonary disease, and a favorable performance status are good candidates for surgical consolidation. Careful patient selection is mandatory. - Providing prostate cancer survivorship care in Japan: Implications from the USA care model
Takahiro Osawa, Daniela Wittmann, Masahito Jimbo, Evan T. Keller, Shunichi Namiki, Takashige Abe, Nobuo Shinohara, Ted A. Skolarus
INTERNATIONAL JOURNAL OF UROLOGY, 23, 11, 906, 915, Nov. 2016, [Peer-reviewed]
English - Aldo-keto reductase 1C1 induced by interleukin-1β mediates the invasive potential and drug resistance of metastatic bladder cancer cells.
Ryuji Matsumoto, Masumi Tsuda, Kazuhiko Yoshida, Mishie Tanino, Taichi Kimura, Hiroshi Nishihara, Takashige Abe, Nobuo Shinohara, Katsuya Nonomura, Shinya Tanaka
Scientific reports, 6, 34625, 34625, 04 Oct. 2016, [Peer-reviewed], [International Magazine]
English, Scientific journal, In treating bladder cancer, determining the molecular mechanisms of tumor invasion, metastasis, and drug resistance are urgent to improving long-term patient survival. One of the metabolic enzymes, aldo-keto reductase 1C1 (AKR1C1), plays an essential role in cancer invasion/metastasis and chemoresistance. In orthotopic xenograft models of a human bladder cancer cell line, UM-UC-3, metastatic sublines were established from tumors in the liver, lung, and bone. These cells possessed elevated levels of EMT-associated markers, such as Snail, Slug, or CD44, and exhibited enhanced invasion. By microarray analysis, AKR1C1 was found to be up-regulated in metastatic lesions, which was verified in metastatic human bladder cancer specimens. Decreased invasion caused by AKR1C1 knockdown suggests a novel role of AKR1C1 in cancer invasion, which is probably due to the regulation of Rac1, Src, or Akt. An inflammatory cytokine, interleukin-1β, was found to increase AKR1C1 in bladder cancer cell lines. One particular non-steroidal anti-inflammatory drug, flufenamic acid, antagonized AKR1C1 and decreased the cisplatin-resistance and invasion potential of metastatic sublines. These data uncover the crucial role of AKR1C1 in regulating both metastasis and drug resistance; as a result, AKR1C1 should be a potent molecular target in invasive bladder cancer treatment. - Laparoscopic resection of paraaortic/paracaval neurogenic tumors: surgical outcomes and technical tips.
Abe T, Sazawa A, Harabayashi T, Oishi Y, Miyajima N, Tsuchiya K, Maruyama S, Okada H, Shinohara N
Surgical endoscopy, 30, 10, 4640, 4645, Oct. 2016, [Peer-reviewed] - Laparoscopic resection of paraaortic/paracaval neurogenic tumors: surgical outcomes and technical tips (vol 30, pg 4640, 2016)
Takashige Abe, Ataru Sazawa, Toru Harabayashi, Yuichiro Oishi, Naoto Miyajima, Kunihiko Tsuchiya, Satoru Maruyama, Hiromi Okada, Nobuo Shinohara
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 30, 10, 4646, 4646, Oct. 2016, [Peer-reviewed]
English - Giant prostate carcinoma: A case report and long-term outcomes in Japanese patients
Jun Furumido, Takashige Abe, Hiroshi Kikuchi, Naoto Miyajima, Kunihiko Tsuchiya, Satoru Maruyama, Nobuo Shinohara
Acta Urologica Japonica, 62, 7, 377, 381, Editorial Board of Acta Urologica Japonica, 01 Jul. 2016, [Peer-reviewed]
Japanese, Scientific journal - A Multi-Center International Study Assessing the Impact of Differences in Baseline Characteristics and Perioperative Care Following Radical Cystectomy.
Osawa T, Lee CT, Abe T, Takada N, Hafez KS, Montgomery JS, Weizer AZ, Hollenbeck BK, Skolarus TA, Murai S, Shinohara N, Morgan TM
Bladder cancer (Amsterdam, Netherlands), 2, 2, 251, 261, Apr. 2016, [Peer-reviewed], [International Magazine]
English, Scientific journal, Background: To identify potential avenues for quality improvement, we compared the variations in clinical practice and their association with perioperative morbidity and mortality following radical cystectomy (RC) for bladder cancer in the United States (US) and Japan. Methods: We reviewed our retrospectively collected database of 2240 patients who underwent RC for bladder cancer at the University of Michigan (n = 1427) and in 21 Japanese institutions (n = 813) between 1997 and 2014. We performed a systematic comparison of clinical and perioperative factors and assessed predictors of perioperative morbidity and mortality. Death within 90 days of surgery was the primary outcome. Results: There were apparent differences between the two study populations. Notably, US patients had a significantly greater BMI and higher ASA score. In Japanese institutions, median postoperative hospital stay was significantly higher (40 days vs. 7 days, p < 0.001) and 90-day readmission rates were significantly lower (0.6% vs. 26.8% , p < 0.001). There was a total of 1372/2240 (61.2%) patients with complications within 90 days and 66/2240 (2.9%) patient deaths. Significant predictors of 90-day mortality were older age (OR 1.04, CI 1.01-1.07), higher body mass index (OR 1.07, CI 1.02-1.12), node-positive disease (OR 3.14, CI 1.78-5.47), increased blood loss (OR 1.02, CI 1.01-1.03), and major (Clavien-grade 3 or greater) complication (OR 3.29, CI 1.88-5.71). Conclusion: Despite major differences in baseline characteristics and care of cystectomy patients between the two study populations, peri-operative mortality rates proved to be comparable. This data supports an exploration of non-traditional factors that may influence mortality after cystectomy. - [Advancement in the treatment against prostate cancer].
Shinohara N, Abe T, Maruyama S
Nihon rinsho. Japanese journal of clinical medicine, 74, 1, 27, 33, 日本臨床社, Jan. 2016, [Peer-reviewed]
Japanese - Prognostic factors and risk classifications for patients with metastatic renal cell carcinoma
Nobuo Shinohara, Takashige Abe
INTERNATIONAL JOURNAL OF UROLOGY, 22, 10, 888, 897, Oct. 2015, [Peer-reviewed]
English - Identification of a subgroup with worse prognosis among patients with poor-risk testicular germ cell tumor
Takahiro Kojima, Koji Kawai, Kunihiko Tsuchiya, Takashige Abe, Nobuo Shinohara, Toshiaki Tanaka, Naoya Masumori, Shigeyuki Yamada, Yoichi Arai, Shintaro Narita, Norihiko Tsuchiya, Tomonori Habuchi, Hiroyuki Nishiyama
INTERNATIONAL JOURNAL OF UROLOGY, 22, 10, 923, 927, Oct. 2015, [Peer-reviewed]
English, Scientific journal - Five-point Likert scaling on MRI predicts clinically significant prostate carcinoma.
Taisuke Harada, Takashige Abe, Fumi Kato, Ryuji Matsumoto, Hiromi Fujita, Sachiyo Murai, Naoto Miyajima, Kunihiko Tsuchiya, Satoru Maruyama, Kohsuke Kudo, Nobuo Shinohara
BMC urology, 15, 91, 91, 04 Sep. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: To clarify the relationship between the probability of prostate cancer scaled using a 5-point Likert system and the biological characteristics of corresponding tumor foci. METHODS: The present study involved 44 patients undergoing 3.0-Tesla multiparametric MRI before laparoscopic radical prostatectomy. Tracing based on pathological and MRI findings was performed. The relationship between the probability of cancer scaled using the 5-point Likert system and the biological characteristics of corresponding tumor foci was evaluated. RESULTS: A total of 102 tumor foci were identified histologically from the 44 specimens. Of the 102 tumors, 55 were assigned a score based on MRI findings (score 1: n = 3; score 2: n = 3; score 3: n = 16; score 4: n = 11 score 5: n = 22), while 47 were not pointed out on MRI. The tracing study revealed that the proportion of >0.5 cm(3) tumors increased according to the upgrade of Likert scores (score 1 or 2: 33%; score 3: 68.8%; score 4 or 5: 90.9%, χ(2) test, p < 0.0001). The proportion with a Gleason score >7 also increased from scale 2 to scale 5 (scale 2: 0%; scale 3: 56.3%; scale 4: 72.7%; 5: 90.9%, χ(2) test, p = 0.0001). On using score 3 or higher as the threshold of cancer detection on MRI, the detection rate markedly improved if the tumor volume exceeded 0.5 cm(3) (<0.2 cm(3): 10.3%; 0.2-0.5 cm(3): 25%; 0.5-1.0 cm(3): 66.7%; 1.0 < cm(3): 92.1%). CONCLUSIONS: Each Likert scale favobably reflected the corresponding tumor's volume and Gleason score. Our observations show that "score 3 or higher" could be a useful threshold to predict clinically significant carcinoma when considering treatment options. - 腎部分切除術後出血・仮性動脈瘤に対するTAE症例の検討
阿保 大介, 作原 祐介, 曽山 武士, 高橋 文也, 工藤 與亮, 安部 崇重, 丸山 覚, 森田 研, 篠原 信雄, 野々村 克也
IVR: Interventional Radiology, 30, 3, 270, 270, (一社)日本インターベンショナルラジオロジー学会, Sep. 2015
Japanese - Prospective mapping of lymph node metastasis in Japanese patients undergoing radical cystectomy for bladder cancer: characteristics of micrometastasis.
Ryuji Matsumoto, Norikata Takada, Takashige Abe, Keita Minami, Toru Harabayashi, Satoshi Nagamori, Kanako C Hatanaka, Naoto Miyajima, Kunihiko Tsuchiya, Satoru Maruyama, Sachiyo Murai, Nobuo Shinohara
Japanese journal of clinical oncology, 45, 9, 874, 80, Sep. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: To investigate node-disease prevalence including micrometastases and its survival impact on bladder cancer patients. METHODS: A total of 60 patients participated in this study, in which extended lymph node dissection was carried out according to the prospective rule (below aortic bifurcation). Radical cystectomy and extended lymph node dissection were performed by open surgery (n = 23) or laparoscopically (n = 37). Perioperative, pathological and follow-up data were collected. Micrometastasis in lymph nodes was investigated by pan-cytokeratin immunohistochemistry. Recurrence-free survival was estimated with the Kaplan-Meier method. RESULTS: The median number of lymph nodes removed was 29 (range: 10-103) and there was no significant difference between the two groups (open group: median 30, laparoscopic group: median 29). Routine pathological examination revealed that 10 patients had lymph node metastases. Immunohistochemistry revealed micrometastases in four additional patients (pNmicro+), who had been diagnosed with pN0 on routine pathological examination. After excluding the three patients with pure nonurothelial carcinoma on the final pathology (small cell carcinoma: n = 2, adenocarcinoma: n = 1), 10 out of the 57 urothelial carcinoma patients (17.5%) had node metastasis, and an additional 4 out of the 47 pN0 patients (4/47, 8.5%) had micrometastasis. The 2-year recurrence-free survival rates divided by pN stage were 82.4% for pN0, 66.7% for pNmicro+ and 12.5% for pN+ (three-sample log-rank test, P < 0.0001). Three out of the four patients with pNmicro+ were disease free at the last follow-up. CONCLUSIONS: We confirmed under extended lymph node dissection that a substantial proportion of the patients had node metastasis (pN+: n = 10 and pNmicro+: n = 4), and the pN stage influenced patient survival. Our observations of micrometastasis yielded additional evidence for the potential survival benefit of extended lymphadenectomy by eliminating microdisease. - Diagnostic outcome of ureteroscopy in urothelial carcinoma of the upper urinary tract: Incidence of later cancer detection and its risk factors after the first examination
Norihiro Murahashi, Takashige Abe, Nobuo Shinohara, Sachiyo Murai, Toru Harabayashi, Ataru Sazawa, Satoru Maruyama, Kunihiko Tsuchiya, Naoto Miyajima, Kanako Hatanaka, Katsuya Nonomura
BMC UROLOGY, 15, 92, Sep. 2015, [Peer-reviewed]
English, Scientific journal - Editorial Comment from Dr Abe to Comparative impact of continent and incontinent urinary diversion on long-term renal function after radical cystectomy in patients with preoperative chronic kidney disease 2 and chronic kidney disease 3a.
Abe T
International journal of urology : official journal of the Japanese Urological Association, 22, 7, 656, Jul. 2015, [Peer-reviewed] - Adaptor protein CRK induces epithelial-mesenchymal transition and metastasis of bladder cancer cells through HGF/c-Met feedback loop.
Ryuji Matsumoto, Masumi Tsuda, Lei Wang, Nako Maishi, Takashige Abe, Taichi Kimura, Mishie Tanino, Hiroshi Nishihara, Kyoko Hida, Yusuke Ohba, Nobuo Shinohara, Katsuya Nonomura, Shinya Tanaka
Cancer science, 106, 6, 709, 17, Jun. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal, We have previously reported that an adaptor protein CRK, including CRK-I and CRK-II, plays essential roles in the malignant potential of various aggressive human cancers, suggesting the validity of targeting CRK in molecular targeted therapy of a wide range of cancers. Nevertheless, the role of CRK in human bladder cancer with marked invasion, characterized by distant metastasis and poor prognosis, remains obscure. In the present study, immunohistochemistry indicated a striking enhancement of CRK-I/-II, but not CRK-like, in human bladder cancer tissues compared to normal urothelium. We established CRK-knockdown bladder cancer cells using 5637 and UM-UC-3, which showed a significant decline in cell migration, invasion, and proliferation. It is noteworthy that an elimination of CRK conferred suppressed phosphorylation of c-Met and the downstream scaffold protein Gab1 in a hepatocyte growth factor-dependent and -independent manner. In epithelial-mesenchymal transition-related molecules, E-cadherin was upregulated by CRK elimination, whereas N-cadherin, vimentin, and Zeb1 were downregulated. A similar effect was observed following treatment with c-Met inhibitor SU11274. Depletion of CRK significantly decreased cell proliferation of 5637 and UM-UC-3, consistent with reduced activity of ERK. An orthotopic xenograft model with bioluminescent imaging revealed that CRK knockdown significantly attenuated not only tumor volume but also the number of circulating tumor cells, resulted in a complete abrogation of metastasis. Taken together, this evidence uncovered essential roles of CRK in invasive bladder cancer through the hepatocyte growth factor/c-Met/CRK feedback loop for epithelial-mesenchymal transition induction. Thus, CRK might be a potent molecular target in bladder cancer, particularly for preventing metastasis, leading to the resolution of clinically longstanding critical issues. - Prognosis of Japanese patients with metastatic renal cell carcinoma who underwent subsequent systemic therapy due to prior failure of VEGF-TKI therapy
Shinohara Nobuo, Obara Wataru, Tatsugami Katsunori, Naito Sei, Kamba Tomomi, Takahashi Masayuki, Abe Takashige, Oba Koji, Naito Seiji
JOURNAL OF CLINICAL ONCOLOGY, 33, 15, 20 May 2015 - Prognosis of Japanese patients with previously untreated metastatic renal cell carcinoma in the era of molecular-targeted therapy.
Nobuo Shinohara, Wataru Obara, Katsunori Tatsugami, Sei Naito, Tomomi Kamba, Masayuki Takahashi, Sachiyo Murai, Takashige Abe, Koji Oba, Seiji Naito
Cancer science, 106, 5, 618, 26, May 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal, A multicenter cooperative study was conducted to clarify the prognosis of Japanese patients with metastatic renal cell carcinoma in the era of molecular-targeted therapy and the clinical usefulness of the Japanese metastatic renal cancer (JMRC) prognostic classification. Of 389 consecutive patients for whom treatment was started between 2008 and 2010 at 23 hospitals in Japan, 357 patients who received vascular endothelial growth factor receptor-tyrosine kinase inhibitor (VEGFR-TKI) or cytokine as initial systemic therapy were the subject of the present study. Patients were classified into three prognostic groups according to the JMRC prognostic classification. The endpoints were progression-free survival (PFS) and overall survival (OS) after the start of the initial treatment. The median PFS and OS for the entire cohort of 357 patients were 9.1 and 27.2 months, respectively. VEGFR-TKI were selected for patients with multiple organ metastases, those with liver metastasis, and those with bone metastasis. The median PFS and OS were 11.0 and 23.2 months and 5.4 and 38.2 months in the VEGFR-TKI group and the cytokines group, respectively. The JMRC prognostic classification was useful as a prognostic model for PFS and OS (c-indexes: 0.613 and 0.630 in patients who initially received VEGFR-TKI and 0.647 and 0.642 in patients who received cytokines, respectively). The present study showed for the first time the prognosis of Japanese patients with metastatic renal cell carcinoma in the era of molecular-targeted therapy. The JMRC prognostic classification may be clinically useful as a prognostic model. - [Present condition and new vista of the future in robotic-assisted laparoscopic surgeries].
Abe T, Maruyama S, Shichinohe T, Honma S, Kudo M, Shinohara N
[Hokkaido igaku zasshi] The Hokkaido journal of medical science, 90, 1, 13, 16, May 2015, [Peer-reviewed] - HIGH ALDO-KETO REDUCTASE 1C1 EXPRESSION IN METASTATIC BLADDER CANCER CELLS ASSOCIATED WITH INVASIVE POTENTIAL AND DRUG RESISTANCE
Matsumoto Ryuji, Tsuda Masumi, Abe Takashige, Maruyama Satoru, Tsuchiya Kunihiko, Miyajima Naoto, Shinohara Nobuo, Tanaka Shinya
JOURNAL OF UROLOGY, 193, 4, E535, Apr. 2015, [Peer-reviewed] - OUTCOME OF METASTATIC UROTHELIAL CARCINOMA IN GC ERA: PROGNOSTIC FACTORS FROM REAL-WORLD CLINICAL PRACTICE IN JAPAN
Ishizaki Junji, Abe Takashige, Minami Keita, Matsumoto Ryuji, Harabayashi Toru, Sazawa Ataru, Mochizuki Tango, Chiba Satoshi, Akino Tomoshige, Murakumo Masahi, Miyajima Naoto, Tsuchiya Kunihiko, Maruyama Satoru, Shinohara Nobuo
JOURNAL OF UROLOGY, 193, 4, E728, Apr. 2015, [Peer-reviewed] - The Effect of Dexmedetomidine on Intraocular Pressure Increase in Patients During Robot-Assisted Laparoscopic Radical Prostatectomy in the Steep Trendelenburg Position
Abe Takashige, Takada Norikata, Matsumoto Ryuji, Osawa Takahiro, Sazawa Ataru, Maruyama Satoru, Tsuchiya Kunihiko, Harabayashi Toru, Minami Keita, Nagamori Satoshi, Hatanaka Kanako C, Tanaka Yuka, Shinohara Nobuo, Nonomura Katsuya
JOURNAL OF ENDOUROLOGY, 29, 3, 304, 309, 01 Mar. 2015, [Peer-reviewed] - Outcome of regional lymphadenectomy in accordance with primary tumor location on laparoscopic nephroureterectomy for urothelial carcinoma of the upper urinary tract: a prospective study.
Takashige Abe, Norikata Takada, Ryuji Matsumoto, Takahiro Osawa, Ataru Sazawa, Satoru Maruyama, Kunihiko Tsuchiya, Toru Harabayashi, Keita Minami, Satoshi Nagamori, Kanako C Hatanaka, Yuka Tanaka, Nobuo Shinohara, Katsuya Nonomura
Journal of endourology, 29, 3, 304, 9, Mar. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: To determine the appropriate template of regional lymph node dissection (LND) at the time of laparoscopic nephroureterectomy (LNU) for patients with clinically node- negative urothelial carcinoma of the upper urinary tract. PATIENTS AND METHODS: This prospective study included 45 patients undergoing LND with LNU in accordance with our prospective rules regarding the area of LND. Perioperative, pathologic, and follow-up data were collected. Micrometastasis in lymph nodes (LNs) was later evaluated by immunohistochemistry (IHC). Recurrence-free survival (RFS) was calculated with the Kaplan-Meier method. RESULTS: The median number of LNs removed was 14 (range 1-33). One patient with pT3 disease had node metastasis based on routine pathologic examination, and IHC revealed micrometastases in two additional patients (pT2 in one and pT3 in one). Therefore, 15% (3/20) of patients with ≥pT2 disease had node disease. After surgery, six patients experienced minor complications (Grade 1 or 2), and Grade 5 gastrointestinal bleeding after aspiration pneumonia developed in one elderly male patient on the 45th postoperative day, which was not considered to be associated with LND. At the last follow-up, lung metastasis developed in four patients (pT1 in one, pT2 in one, and pT3 in two), and presacral lymph node metastasis developed in one patient with a lower ureteral tumor (pT2), which was not included in our prospective template for a lower ureteral tumor. LN recurrence within/ near the LND area was not observed in patients with pelvic/upper ureteral carcinoma. The 2-year nonurothelial RFS rate was 84%. CONCLUSIONS: We consider that the present template represents regional LNs for patients with clinically node-negative pelvic/upper ureteral carcinoma, while presacral LNs may be incorporated into the regional LND template for patients with clinically node-negative lower ureteral carcinoma. - The significance of metastasectomy in patients with metastatic renal cell carcinoma
Haruka Miyata, Nobuo Shinohara, Norihiro Murahashi, Kunihiko Tsuchiya, Naoto Miyajima, Satoru Maruyama, Takashige Abe, Kichizo Kaga, Satoshi Hirano, Katsuya Nonomura
Acta Urologica Japonica, 61, 2, 49, 54, Editorial Board of Acta Urologica Japonica, 01 Feb. 2015, [Peer-reviewed]
Japanese, Scientific journal - Concurrent occurrence of renal cell carcinoma with rhabdoid features in a married couple: a case report.
Ryuji Matsumoto, Nobuo Shinohara, Kanako C-Hatanaka, Naoto Kuroda, Kunihiko Tsuchiya, Satoru Maruyama, Takashige Abe, Katsuya Nonomura
BMC research notes, 8, 3, 3, 15 Jan. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Renal cell carcinoma (RCC) with rhabdoid features is a rare histology and exhibits clinically aggressive behavior. We report a case of a married couple in whom RCC with rhabdoid features concurrently occurred. The rarity of this event suggests that environmental factors may contribute to the etiology of RCC with rhabdoid features. CASE PRESENTATION: A 76-year-old Japanese woman was diagnosed with a hypervascular mass in the right kidney and tumor thrombus extending into the right atrium by enhanced computed tomography (CT). She underwent radical nephrectomy and tumor thrombectomy following systemic therapy with the tyrosine kinase inhibitor sunitinib. The histological evaluation denoted clear cell RCC with rhabdoid features. The patient died of cancer 12 months postoperatively. A 76-year-old man, her husband, presented with gross hematuria 2 weeks after his wife had undergone surgery. He had a long history of asbestos exposure. An abdominal CT scan revealed a hypervascular mass in the right kidney and tumor thrombus extending into the inferior vena cava. He also underwent radical nephrectomy and tumor thrombectomy. The histological evaluation also showed clear cell RCC with rhabdoid features. Bone metastasis occurred 12 months postoperatively, but he died of an unrelated cause 18 months after surgery. CONCLUSION: Concurrent occurrence of RCC with rhabdoid features may not to be coincidental. Although further studies are warranted, asbestos exposure may contribute to the etiology of clear cell RCC with rhabdoid features. - Comparison of 90-day complications between ileal conduit and neobladder reconstruction after radical cystectomy: a retrospective multi-institutional study in Japan.
Takashige Abe, Norikata Takada, Nobuo Shinohara, Ryuji Matsumoto, Sachiyo Murai, Ataru Sazawa, Satoru Maruyama, Kunihiko Tsuchiya, Shino Kanzaki, Katsuya Nonomura
International journal of urology : official journal of the Japanese Urological Association, 21, 6, 554, 9, Jun. 2014, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: To determine the differences in the type, incidence, and severity of 90-day morbidity after radical cystectomy between two different methods of urinary diversion, ileal conduit and neobladder. METHODS: We carried out a retrospective multi-institutional study by reviewing the records of 668 patients treated with open radical cystectomy, and ileal conduit (n = 493) or neobladder substitution (n = 175) between 1997 and 2010. All complications within 90 days after surgery were divided into 11 specific categories as reported by the Memorial-Sloan Kettering Cancer Center, and graded according to the modified Clavien system. Type, incidence and severity of the 90-day morbidity between the two different types of urinary diversions were compared. RESULTS: There was no significant difference in the overall complication rates between the two groups (ileal conduit: 72% [353/493], neobladder: 74% [129/175], P = 0.5909), whereas the neobladder group had fewer major (grade 3 or more) complications (13 vs 20%, respectively, P = 0.0271). The neobladder group had more infectious complications (43 vs 31%, respectively, P = 0.0037), mainly as a result of urinary tract infection, whereas the ileal conduit group had more wound-related complications (24 vs 14%, respectively, P = 0.0068), mainly as a result of surgical site infection. The 90-day mortality rates were 1.1% (2/175) in the neobladder group and 1.6% (8/493) in the ileal conduit group (P = 0.6441). CONCLUSIONS: There was no significant difference in the overall complication rates between the two methods, and patients with neobladder had fewer major complications. The neobladder group had more infectious complications, whereas the ileal conduit group had more wound-related complications. - RENAL nephrometry score is a predictive factor for the annual growth rate of renal mass.
Ryuji Matsumoto, Takashige Abe, Nobuo Shinohara, Sachiyo Murai, Satoru Maruyama, Kunihiko Tsuchiya, Katsuya Nonomura
International journal of urology : official journal of the Japanese Urological Association, 21, 6, 549, 52, Jun. 2014, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: To evaluate the association between the RENAL nephrometry score and annual growth rates of renal masses presumed to be renal cell carcinoma. METHODS: The current study included 47 renal tumors followed up for at least 12 months, of which 26 tumors were found to be pathologically proven renal cell carcinomas. Annual tumor growth rates were calculated from changes in the maximal diameter on computed tomography, and RENAL nephrometry scores were recorded on initial imaging by two senior urologists. The associations between clinical characteristics including the RENAL nephrometry score and annual growth rates were analyzed using a linear regression model. RESULTS: The median tumor size at diagnosis was 1.7 cm (range 0.6-5.8). The median nephrometry score at diagnosis was 7 (range 4-10). Overall, the median tumor growth rate was 0.34 cm per year (range -0.19-2.0). Linear regression analysis showed that the annual tumor growth rate was associated with the RENAL nephrometry score (P < 0.0001), but it was independent of the age at diagnosis, sex and initial tumor size. In addition, the correlation between the RENAL nephrometry score and annual growth rate remained significant in the 26 pathologically proven renal cell carcinomas. CONCLUSIONS: The RENAL nephrometry score is associated with the annual growth rate of renal masses. Our findings further support the association between the RENAL nephrometry score and tumor biology. - Early results of urethral dose reduction and small safety margin in intensity-modulated radiation therapy (IMRT) for localized prostate cancer using a real-time tumor-tracking radiotherapy (RTRT) system
Shinichi Shimizu, Kentaro Nishioka, Ryusuke Suzuki, Nobuo Shinohara, Satoru Maruyama, Takashige Abe, Rumiko Kinoshita, Norio Katoh, Rikiya Onimaru, Hiroki Shirato
RADIATION ONCOLOGY, 9, 118, May 2014, [Peer-reviewed]
English, Scientific journal - Outcome of Metastasectomy for Urothelial Carcinoma: A Multi-Institutional Retrospective Study in Japan
Takashige Abe, Hiroshi Kitamura, Wataru Obara, Nagahide Matsumura, Taiji Tsukamoto, Tomoaki Fujioka, Isao Hara, Sachiyo Murai, Nobuo Shinohara, Katsuya Nonomura
JOURNAL OF UROLOGY, 191, 4, 932, 936, Apr. 2014, [Peer-reviewed]
English, Scientific journal - The significance of protocol biopsy after intravesical BCG treatment in patients with non-muscle-invasive bladder cancer.
Maruyama Satoru, Shinohara Nobuo, Murahashi Norihiro, Suzuki Hidetaka, Matsumoto Ryuji, Akino Tomoshige, Miyajima Naoto, Tsuchiya Kunihiko, Abe Takashige, Nonomura Katsuya
JOURNAL OF CLINICAL ONCOLOGY, 32, 4, 01 Feb. 2014, [Peer-reviewed] - Prospective Phase II Study of Image-guided Local Boost Using a Real-time Tumor-tracking Radiotherapy (RTRT) System for Locally Advanced Bladder Cancer
Kentaro Nishioka, Shinichi Shimizu, Nobuo Shinohara, Yoichi M. Ito, Takashige Abe, Satoru Maruyama, Rumiko Kinoshita, Keiichi Harada, Noboru Nishikawa, Naoki Miyamoto, Rikiya Onimaru, Hiroki Shirato
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 44, 1, 28, 35, Jan. 2014, [Peer-reviewed]
English, Scientific journal - Longitudinal comparison of quality of life after real-time tumor-tracking intensity-modulated radiation therapy and radical prostatectomy in patients with localized prostate cancer.
Nobuo Shinohara, Satoru Maruyama, Shinichi Shimizu, Kentaro Nishioka, Takashige Abe, Kanako C-Hatanaka, Koji Oba, Katsuya Nonomura, Hiroki Shirato
Journal of radiation research, 54, 6, 1095, 101, 01 Nov. 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal, The purpose of this study was to compare the quality of life (QOL) in patients with localized prostate cancer (PC) after intensity-modulated radiation therapy assisted with a fluoroscopic real-time intensity-modulated radiation therapy (RT-IMRT) tumor-tracking system versus the QOL after radical prostatectomy (RP). Between 2003 and 2006, 71 patients were enrolled in this longitudinal prospective study. Each patient was allowed to decide which treatment modality they would receive. Of the 71 patients, 23 patients underwent RT-IMRT, while 48 opted for RP. No patient received neo-adjuvant or adjuvant hormone therapy. The global QOL and disease-specific-QOL were evaluated before treatment and again at 1, 3 and 5 years after treatment. There was no significant difference in the background characteristics between the two groups. The 5-year biochemical progression-free survival was 90% in the RT-IMRT and 79% in the RP group. In the RT-IMRT group, there was no significant deterioration of the global QOL or disease-specific QOL through 5 years post-treatment. In the RP group, the urinary function, sexual function, and sexual bother indicators significantly deteriorated after treatment. Urinary and sexual function was significantly better in the RT-IMRT group at 1, 3 and 5 years post-treatment compared to the RP group. RT-IMRT may be a preferable treatment for localized PC because of similar efficacy to RP but better post-treatment QOL. - Impacts of clinicopathologic and operative factors on short-term and long-term survival in renal cell carcinoma with venous tumor thrombus extension: A multi-institutional retrospective study in Japan
Masanori Hirono, Mikio Kobayashi, Tomoyasu Tsushima, Wataru Obara, Nobuo Shinohara, Keiichi Ito, Masatoshi Eto, Tatsuya Takayama, Yasuhisa Fujii, Masaharu Nishikido, Go Kimura, Takeshi Kishida, Masayuki Takahashi, Noriomi Miyao, Yukio Naya, Takashige Abe, Tomoaki Fujioka, Kazuto Ito, Seiji Naito
BMC Cancer, 13, 447, 02 Oct. 2013, [Peer-reviewed]
English, Scientific journal - Safety, Stability, and Location of Implantation of Multiple Gold Markers Into the Soft Bladder Wall by Rigid Cystoscopy
K. Nishioka, S. Shimizu, R. Onimaru, R. Kinoshita, N. Kato, K. Harada, T. Abe, S. Maruyama, N. Shinohara, H. Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 87, 2, S397, S397, Oct. 2013, [Peer-reviewed]
English - Is Memorial Sloan-Kettering Cancer Center risk classification appropriate for Japanese patients with metastatic renal cell carcinoma in the cytokine era?
Nobuo Shinohara, Takashige Abe, Tango Mochizuki, Akira Kashiwagi, Kouichi Kanagawa, Satoru Maruyama, Ataru Sazawa, Koji Oba, Katsuya Nonomura
Urologic oncology, 31, 7, 1276, 82, Oct. 2013, [Peer-reviewed], [International Magazine]
English, OBJECTIVES: We investigated the prognosis of Japanese patients with metastatic renal cell carcinoma (RCC), and analyzed the validity of Memorial Sloan-Kettering Cancer Center (MSKCC) risk classification. MATERIALS AND METHODS: The endpoint of the present study was overall survival. Relationships between overall survival and potential prognostic factors were assessed using the Cox proportional hazard model with a step-wise procedure. Prognostic assessment was also performed according to the MSKCC risk classification. The predictive accuracy of the MSKCC risk classification was measured employing the concordance index. RESULTS: The median survival for all patients was 22 months (95% CI, 19-28 months). The eight factors were identified as independent prognostic factor; time from initial diagnosis to metastasis, low hemoglobin (Hb), lactate dehydrogenase (LDH), corrected serum calcium (cCa), C-reactive protein (CRP), and the presence or absence of liver metastasis, bone metastasis, and lymph node metastasis. When the MSKCC risk classification was applied to patients, the median overall survival was not reached and 26 and 10 months in the patients classified as favorable, intermediate, and poor risk, respectively. The c-index was 0.73. CONCLUSIONS: The prognosis of Japanese metastatic renal cell carcinoma patients may be better than that of previous studies from North America or Europe. Although there are some differences in the rate of patients in the risk groups and survival time by risk group between these patients, the MSKCC risk classification may be applicable for Japanese patients with metastatic renal cell carcinoma. - Long-term renal function outcomes in bladder cancer after radical cystectomy.
Takahiro Osawa, Nobuo Shinohara, Satoru Maruyama, Koji Oba, Takashige Abe, Shintaro Maru, Norikata Takada, Ataru Sazawa, Katsuya Nonomura
Urology journal, 10, 1, 784, 9, 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: To evaluate postoperative renal function and risk factors for the loss of renal function in patients who had undergone radical cystectomy. MATERIALS AND METHODS: A retrospective single institutional study evaluated 70 patients, including 54 men and 16 women who underwent radical cystectomy. The median follow-up period was 34.5 months (range, 12 to 228 months). In this cohort, four types of urinary diversions were studied, including ileal neobladder (n = 24), ileocecal neobladder (n = 12), ileal conduit (n = 25), and cutaneous ureterostomy (n = 9). Postoperative changes in renal function were reviewed, and the estimated serum creatinine-based glomerular filtration rate (eGFR) was calculated. The variables analyzed were age, a prior history of hypertension or diabetes mellitus, pre-operative renal function, type of urinary diversion, the postoperative occurrence of acute pyelonephritis, and the presence of chemotherapy. RESULTS: The mean eGFR was 74.6 (range, 15.2 to 155.1) mL/min/1.73 m² before surgery and 63.6 (range, 8.7 to 111.5) mL/min/1.73 m² at the last follow-up. The 10-year renal deterioration-free interval was 63.8%. Multivariate analysis showed that a postoperative episode of acute pyelonephritis [Odds Ratio (OR), 3.21; 95% Confidence Interval (CI), 1.14 to 9.02; P = .03] and the presence of chemotherapy (OR, 3.27; 95% CI, 1.33 to 8.01; P = .01) were significant adverse factors. CONCLUSION: Twenty-four (34.2%) patients demonstrated reduced renal function during the follow-up period. Postoperative episodes of acute pyelonephritis and the presence of chemotherapy were found to be significant adverse factors. - Peri-operative morbidity and mortality related to radical cystectomy: a multi-institutional retrospective study in Japan
Norikata Takada, Takashige Abe, Nobuo Shinohara, Ataru Sazawa, Satoru Maruyama, Yuichiro Shinno, Soshu Sato, Kimiyoshi Mitsuhashi, Takuya Sato, Keiji Sugishita, Shinji Kamota, Takanori Yamashita, Junji Ishizaki, Takaya Hioka, Gaku Mouri, Takenori Ono, Naoto Miyajima, Takanori Sakuta, Tango Mochizuki, Toshiki Aoyagi, Hidenori Katano, Tomoshige Akino, Kazushi Hirakawa, Keita Minami, Akira Kumagai, Toshimori Seki, Masaki Togashi, Katsuya Nonomura
BJU INTERNATIONAL, 110, 11B, E756, E764, Dec. 2012, [Peer-reviewed]
English, Scientific journal - Interfractional Setup Error and Intrafractional Bladder Motion During Radiation Therapy for Bladder Tumors
K. Nishioka, S. Shimizu, R. Onimaru, R. Kinoshita, K. Harada, N. Nishikawa, T. Abe, S. Maruyama, N. Shinohara, H. Shirato
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 84, 3, S769, S769, Nov. 2012, [Peer-reviewed]
English - Renal hypothermia with ice slush in laparoscopic partial nephrectomy: the outcome of renal function.
Takashige Abe, Ataru Sazawa, Toru Harabayashi, Nobuo Shinohara, Satoru Maruyama, Ken Morita, Ryuji Matsumoto, Toshiki Aoyagi, Katsuya Nonomura
Journal of endourology, 26, 11, 1483, 8, Nov. 2012, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: To investigate changes in renal function after retroperitoneal laparoscopic partial nephrectomy (LPN) with renal hypothermia induced by ice-slush cooling. PATIENTS AND METHODS: Seventy-one patients undergoing retroperitoneal LPN with renal hypothermia were included. Perioperative outcomes were reviewed retrospectively. The total renal function was evaluated by an estimated glomerular filtration rate (eGFR) preoperatively and 6 months postoperatively in 69 patients. Split renal function (SRF) was also evaluated by 99mTc-mercaptoacetyltriglycine scintigraphy preoperatively and 6 months postoperatively in 61 patients. RESULTS: The median operative time was 246 minutes (range, 155-424). The median cold ischemic time, including the initial 15 minutes of hypothermia, was 57 minutes (range, 34-112). In the 21 patients whose renal temperature was monitored, median lowest renal temperature was 20.7°C (range, 12.1-27.6). The median baseline eGFR and 6-month postoperative eGFR were 77.2 mL/min/1.73 m(2) (range, 36.1-121.3) and 68.3 mL/min/1.73 m(2) (range, 33.2-103.4), and the median baseline SRF and 6-month postoperative SRF of the affected kidney were 49.3% (range, 40.3-57.6) and 40.7% (range, 13.8-54.5). Using multivariate analysis, the baseline eGFR (p<0.0001) and the ischemic time (p=0.0073) were associated with the 6-month postoperative eGFR, and the 6-month postoperative SRF was only associated with a baseline SRF (p=0.0185). CONCLUSIONS: Ice-slush cooling could provide renal hypothermia also under LPN. The decrease in renal function was small, whereas our ischemic time was longer than experts' warm ischemic series. These observations suggested the protective effect of our cooling methods against ischemic injury. - A new prognostic classification for overall survival in Asian patients with previously untreated metastatic renal cell carcinoma.
Nobuo Shinohara, Katsuya Nonomura, Takashige Abe, Satoru Maruyama, Takao Kamai, Masayuki Takahashi, Katsunori Tatsugami, Shigeaki Yokoi, Takashi Deguchi, Hiroomi Kanayama, Koji Oba, Seiji Naito
Cancer science, 103, 9, 1695, 700, Sep. 2012, [Peer-reviewed], [International Magazine]
English, The aims of the present study were to: (i) develop a clinically useful prognostic classification in Asian patients with metastatic renal cell carcinoma (RCC) by combining metastatic features with several pretreatment parameters; and (ii) evaluate the validity of this prognostic classification. Baseline characteristics and outcomes were collected for 361 patients who underwent interferon-α-based therapy between 1995 and 2005. Relationships between overall survival (OS) and potential prognostic factors were assessed using Cox's proportional hazard model. The predictive performance of the model was evaluated using bootstrap resampling procedures and by using an independent dataset obtained from randomly selected institutions. The predictive accuracy was measured using the concordance index (c-index). Four factors were identified as independent prognostic factors: time from initial diagnosis to treatment, anemia, elevated lactate dehydrogenase (LDH), and poor prognostic metastatic group (liver only, bone only, or multiple organ metastases). Each patient was assigned to one of three risk groups: favorable risk (none or one factor; n = 120), in which median OS was 51 months; intermediate risk (two factors; n = 101), in which median OS was 21 months; and poor risk (three or four factors; n = 102), in which median OS was 10 months. The c-index was 0.72 in the original dataset and 0.72 in 500 random bootstrap samples. In the independent dataset for external validation, the c-index was 0.73. Thus, the new prognostic classification is easily applicable for Asian patients with previously untreated metastatic RCC and should be incorporated into patient care, as well as clinical trials performed in Asia. - 北海道大学病院における褐色細胞腫に対する鏡視下及び開腹手術の比較検討
広瀬 貴行, 原林 透, 安部 崇重, 丸山 覚, 三浦 正義, 佐澤 陽, 篠原 信雄, 野々村 克也
泌尿器外科, 25, 7, 1573, 1573, 医学図書出版(株), Jul. 2012
Japanese - Changes in Urodynamics and Lower Urinary Tract Symptoms after Radical Prostatectomy: Implications of Preoperative Detrusor Contractility
Takahiko Mitsui, Hiroshi Tanaka, Toru Harabayashi, Kimihiko Moriya, Satoru Maruyama, Takashige Abe, Ataru Sazawa, Nobuo Shinohara, Katsuya Nonomura
LUTS-LOWER URINARY TRACT SYMPTOMS, 4, 2, 82, 86, May 2012, [Peer-reviewed]
English, Scientific journal - Interferon-alpha-based Immunotherapy in Metastatic Renal Cell Carcinoma Patients with the Primary Tumor In Situ
Nobuo Shinohara, Takashige Abe, Ataru Sazawa, Satoru Maruyama, Junri Shindo, Soshu Sato, Shin Suzuki, Katsuya Nonomura
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 42, 2, 113, 119, Feb. 2012, [Peer-reviewed]
English, Scientific journal - Influence of baseline renal function and dose reduction of nephrotoxic chemotherapeutic agents on the outcome of metastatic urothelial carcinoma: A retrospective study
Shintaro Maru, Takashige Abe, Nobuo Shinohara, Ataru Sazawa, Satoru Maruyama, Toru Harabayashi, Shin Suzuki, Katsuya Nonomura
INTERNATIONAL JOURNAL OF UROLOGY, 19, 2, 110, 116, Feb. 2012, [Peer-reviewed]
English, Scientific journal - RENAL HYPOTHERMIA WITH ICE SLUSH IN LAPAROSCOPIC PARTIAL NEPHRECTOMY
Abe Takashige, Sazawa Ataru, Harabayashi Toru, Matsumoto Ryuji, Aoyagi Toshiki, Maruyama Satoru, Shinohara Nobuo, Nonomura Katsuya
JOURNAL OF ENDOUROLOGY, 25, A186, Nov. 2011, [Peer-reviewed] - Outcome of Regional Lymph Node Dissection in Conjunction with Laparoscopic Nephroureterectomy for Urothelial Carcinoma of the Upper Urinary Tract
Takashige Abe, Toru Harabayashi, Nobuo Shinohara, Ataru Sazawa, Satoru Maruyama, Hajime Sasaki, Katsuya Nonomura
JOURNAL OF ENDOUROLOGY, 25, 5, 803, 807, May 2011, [Peer-reviewed]
English, Scientific journal - Impact of Diagnostic Ureteroscopy on Intravesical Recurrence and Survival in Patients With Urothelial Carcinoma of the Upper Urinary Tract
Shuhei Ishikawa, Takashige Abe, Nobuo Shinohara, Toru Harabayashi, Ataru Sazawa, Satoru Maruyama, Kanako Kubota, Yoshihiro Matsuno, Takahiro Osawa, Yuichiro Shinno, Akira Kumagai, Masaki Togashi, Hiroyuki Matsuda, Tatsuya Mori, Katsuya Nonomura
JOURNAL OF UROLOGY, 184, 3, 883, 887, Sep. 2010, [Peer-reviewed]
English, Scientific journal - Pathological characteristics and clinical course of bladder tumour developing after nephroureterectomy
Takashige Abe, Nobuo Shinohara, Toru Harabayashi, Ataru Sazawa, Tomoshige Akino, Shuhei Ishikawa, Kanako Kubota, Yoshihiro Matsuno, Takahiro Osawa, Takeshi Shibata, Yutaka Toyoda, Yuichiro Shinno, Shinji Kamota, Keita Minami, Shigeo Sakashita, Akira Kumagai, Norikata Takada, Masaki Togashi, Hiroshi Sano, Tatsuya Mori, Katsuya Nonomura
BJU INTERNATIONAL, 105, 8, 1102, 1106, Apr. 2010, [Peer-reviewed]
English, Scientific journal - Multicenter Phase II Trial of Combination Therapy with Meloxicam, a COX-2 Inhibitor, and Natural Interferon-alpha for Metastatic Renal Cell Carcinoma
Nobuo Shinohara, Akira Kumagai, Kouichi Kanagawa, Satoru Maruyama, Takashige Abe, Ataru Sazawa, Katsuya Nonomura
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 39, 11, 720, 726, Nov. 2009, [Peer-reviewed]
English, Scientific journal - Alternative approach in the treatment of adrenal metastasis with a real-time tracking radiotherapy in patients with hormone refractory prostate cancer
Ataru Sazawa, Nobuo Shinohara, Toru Harabayashi, Takashige Abe, Hiroki Shirato, Katsuya Nonomura
INTERNATIONAL JOURNAL OF UROLOGY, 16, 4, 410, 412, Apr. 2009, [Peer-reviewed]
English, Scientific journal - Role of lymph node density in predicting survival of patients with lymph node metastases after radical cystectomy: A multi-institutional study
Takahiro Osawa, Takashige Abe, Nobuo Shinohara, Toru Harabayashi, Ataru Sazawa, Kanako Kubota, Yoshihiro Matsuno, Takeshi Shibata, Yuichiro Shinno, Shinji Kamota, Keita Minami, Shigeo Sakashita, Akira Kumagai, Tatsuya Mori, Katsuya Nonomura
INTERNATIONAL JOURNAL OF UROLOGY, 16, 3, 274, 278, Mar. 2009, [Peer-reviewed]
English, Scientific journal - A case of primary leiomyosarcoma of the seminal vesicle
Tatsuhiro Suzuki, Toru Harabayashi, Takashige Abe, Ataru Sazawa, Nobuo Shinohara, Katsuya Nonomura
Japanese Journal of Urology, 100, 7, 703, 706, Japanese Urological Association, 2009, [Peer-reviewed]
Japanese, Scientific journal - The role of lymph-node dissection in the treatment of upper urinary tract cancer: a multi-institutional study
Takashige Abe, Nobuo Shinohara, Toru Harabayashi, Ataru Sazawa, Shuhei Ishikawa, Kanako Kubota, Yoshihiro Matsuno, Takahiro Osawa, Takeshi Shibata, Yuichiro Shinno, Shinji Kamota, Keita Minami, Shigeo Sakashita, Ichiro Takeuchi, Akira Kumagai, Tatsuya Mori, Masaki Togashi, Katsuya Nonomura
BJU INTERNATIONAL, 102, 5, 576, 579, Sep. 2008, [Peer-reviewed]
English, Scientific journal - Infiltration of Epstein-Barr virus-harboring lymphocytes occurs in a large subset of bladder cancers
Takashige Abe, Nobuo Shinohara, Mitsuhiro Tada, Toru Harabayashi, Ataru Sazawa, Satoru Maruyama, Tetsuya Moriuchi, Kenzo Takada, Katsuya Nonomura
INTERNATIONAL JOURNAL OF UROLOGY, 15, 5, 429, 434, May 2008, [Peer-reviewed]
English, Scientific journal - Impact of multimodal treatment on survival in patients with metastatic urothelial cancer
Takashige Abe, Nobuo Shinohara, Toru Harabayashi, Ataru Sazawa, Satoru Maruyama, Shin Suzuki, Katsuya Nonomura
EUROPEAN UROLOGY, 52, 4, 1106, 1114, Oct. 2007, [Peer-reviewed]
English, Scientific journal - Survival and prognostic classification of patients with metastatic renal cell carcinoma of bone
Yutaka Toyoda, Nobuo Shinohara, Toru Harabayashi, Takashige Abe, Tomoshige Akino, Ataru Sazawa, Katsuya Nonomura
EUROPEAN UROLOGY, 52, 1, 163, 169, Jul. 2007, [Peer-reviewed]
English, Scientific journal - Postoperative inguinal hernia after radical prostatectomy for prostate cancer
Takashige Abe, Nobuo Shinohara, Toru Harabayashi, Ataru Sazawa, Shin Suzuki, You Kawarada, Katsuya Nonomura
UROLOGY, 69, 2, 326, 329, Feb. 2007, [Peer-reviewed]
English, Scientific journal - Establishment and characterization of human urothelial cancer xenografts in severe combined immunodeficient mice
T Abe, M Tada, N Shinohara, F Okada, T Itoh, JI Hamada, T Harabayashi, QZ Chen, T Moriuchi, K Nonomura
INTERNATIONAL JOURNAL OF UROLOGY, 13, 1, 47, 57, Jan. 2006, [Peer-reviewed]
English, Scientific journal - Impact of cyclooxygenase-2 gene expression on tumor invasiveness in a human renal cell carcinoma cell line
QZ Chen, N Shinohara, T Abe, T Harabayashi, K Nonomura
JOURNAL OF UROLOGY, 172, 6, 2153, 2157, Dec. 2004, [Peer-reviewed]
English, Scientific journal - Impact of adjuvant systemic chemotherapy on postoperative survival in patients with high-risk urothelial cancer
S Suzuki, N Shinohara, T Harabayashi, S Sato, T Abe, T Koyanagi
INTERNATIONAL JOURNAL OF UROLOGY, 11, 7, 456, 460, Jul. 2004, [Peer-reviewed]
English, Scientific journal - Significance of COX-2 expression in human renal cell carcinoma cell lines
QZ Chen, N Shinohara, T Abe, T Watanabe, K Nonomura, T Koyanagi
INTERNATIONAL JOURNAL OF CANCER, 108, 6, 825, 832, Mar. 2004, [Peer-reviewed]
English, Scientific journal - Peritoneal carcinomatosis in refractory seminoma
T Abe, N Shinohara, T Harabayashi, K Tsuchiya, S Suzuki, T Itoh, T Seki, M Togashi, K Nonomura, T Koyanagi
INTERNATIONAL JOURNAL OF UROLOGY, 11, 3, 184, 186, Mar. 2004, [Peer-reviewed]
English, Scientific journal - Criteria for general practitioners to assess treatment efficacy for urination problems of the elderly
Kikuo Okamura, Katsushi Nagahama, Takatoshi Usami, Hirohiko Nagata, Takashige Abe, Satoshi Katsuno, Keizo Kawano, Shigenori Sato, Masaki Harada
Japanese Journal of Geriatrics, 40, 4, 352, 359, 2003, [Peer-reviewed]
Japanese, Scientific journal - Initial assessment criteria for urination problems of the elderly - Comparison of criteria for patients/caregivers/nurses, general practitioners, and urologists
Kikuo Okamura, Katsushi Nagahama, Takatoshi Usami, Hirohiko Nagata, Takashige Abe, Satoshi Katsuno, Keizo Kawano, Shigenori Sato, Masaki Harada
Japanese Journal of Geriatrics, 40, 4, 360, 367, 2003, [Peer-reviewed]
Japanese, Scientific journal - Ectopic pheochromocytoma arising in the spermatic cord 5 years after removal of bilateral carotid body tumors and adrenal pheochromocytomas
Takashige Abe, Hiroyuki Matsuda, Junri Shindo, Katsuya Nonomura, Tomohiko Koyanagi
International Journal of Urology, 7, 3, 110, 111, Mar. 2000
English, Scientific journal - Acute renal failure occuring from urinary retention due to a mullerian duct cyst
Takashige Abe, Yuichiro Shinno, Koichi Kawakura, Kimihiko Moriya
International Journal of Urology, 7, 2, 69, 71, Feb. 2000
English, Scientific journal
Other Activities and Achievements
- 腎がん免疫複合療法中の免疫関連有害事象の発生は予後因子となるのか?
吉田あゆ, 大澤崇宏, 東海林旺次朗, 宮田遥, 松本隆児, 安部崇重, 篠原信雄, 腎癌研究会会報, 54, 2024 - Importance of health-related quality of life in the pharmacotherapy of patients with renal cancer
大澤崇宏, 宮田遥, 松本隆児, 安部崇重, 篠原信雄, 日本泌尿器科学会総会(Web), 111th, 2024 - Treatment strategy for oligometastatic urothelial carcinoma
安部崇重, 宮田遥, 松本隆児, 大澤崇宏, 菊地央, 篠原信雄, 泌尿器外科, 37, 2024 - Open retroperitoneal lymph node dissection for testicular cancer: Surgical education of open surgery in ”Robotics” era
安部崇重, 宮田遥, 松本隆児, 大澤崇宏, 菊地央, 篠原信雄, 泌尿器外科, 37, 2024 - 当院におけるHBOC症例のフォローアップに関する調査
佐々木 佑菜, 三田村 卓, 松本 隆児, 桑谷 将城, 細田 充主, 安部 崇重, 柴田 有花, 松島 理明, 矢部 一郎, 山田 崇弘, 日本遺伝カウンセリング学会誌, 44, 2, 137, 137, Jun. 2023
(一社)日本遺伝カウンセリング学会, Japanese - オリゴ転移尿路上皮癌に対する治療戦略
安部崇重, 宮田遥, 菊地央, 松本隆児, 大澤崇宏, 篠原信雄, 日本泌尿器科学会東部総会プログラム・抄録集, 88th (CD-ROM), 2023 - 精巣癌に対する開腹後腹膜リンパ節郭清術 ロボット時代の手術教育についてわたくしが今思うこと
安部崇重, 宮田遥, 菊地央, 松本隆児, 大澤崇宏, 篠原信雄, 日本泌尿器科学会東部総会プログラム・抄録集, 88th (CD-ROM), 2023 - 当院における転移性尿路上皮癌に対するエンホルツマブベトチンの治療成績
松本隆児, 宮田遥, 大澤崇宏, 安部崇重, 篠原信雄, 日本泌尿器科学会東部総会プログラム・抄録集, 88th (CD-ROM), 2023 - The development of the data correction method and feature extraction for the skill evaluation of practical laparoscopic surgical training
海老名光希, 安部崇重, YAN Lingbo, 堀田記世彦, 今雅史, 樋口まどか, 古御堂純, 岩原直也, 小水内俊介, 倉島庸, 菊地央, 松本隆児, 大澤崇宏, 村井祥代, 辻田哲平, 佐瀬一弥, CHEN Xiaoshuai, 妹尾拓, 篠原信雄, 近野敦, 日本機械学会ロボティクス・メカトロニクス講演会講演論文集(CD-ROM), 2023, 2023 - ステントグラフト内挿術後に外科的治療を要した尿管動脈瘻の1例
杉戸 悠紀, 堀田 記世彦, 山田 修平, 千葉 博基, 松本 隆児, 大澤 崇宏, 安部 崇重, 阿保 大介, 佐藤 公治, 若狭 哲, 篠原 信雄, 日本泌尿器科学会雑誌, 113, 4, 134, 138, Oct. 2022
(一社)日本泌尿器科学会, Japanese - The development and validation of a measurement system for laparoscopic surgery in practical surgical training
海老名光希, 安部崇重, 堀田記世彦, 樋口まどか, 古御堂純, 岩原直也, 今雅史, 小水内俊介, 倉島庸, 菊地央, 松本隆児, 大澤崇宏, 村井祥代, 辻田哲平, 佐瀬一弥, CHEN Xiaoshuai, 妹尾拓, 篠原信雄, 近野敦, 計測自動制御学会システムインテグレーション部門講演会(CD-ROM), 23rd, 2022 - TURBT時の死冠(corona mortis)損傷による致命的な出血性ショックに対してTAEにて救命し得た1例
黒沢瞭, 堀田記世彦, 阿保大介, 岩見大基, 安部崇重, 田邉起, 大澤崇宏, 松本隆児, 篠原信雄, 泌尿器外科, 34, 3, 2021 - 術後意識障害の原因診断に苦慮した下大静脈腫瘍血栓を伴う左腎癌の1例
岩原直也, 安部崇重, 山田修平, 古御堂純, 菊地央, 松本隆児, 大澤隆宏, 篠原信雄, 泌尿器外科, 34, 3, 2021 - MOTION ANALYSIS TO PROMOTE UNDERSTANDING OF LAPAROSCOPIC SURGERY-DEXTERITY AND OBJECTIVE ASSESSMENT-BASED SIMULATION TRAINING
Takashige Abe, Koki Ebina, Madoka Higuchi, Jun Furumido, Naoya Iwahara, Masafumi Kon, Kiyohiko Hotta, Shunsuke Komizunai, Yo Kurashima, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Atsushi Konno, Nobuo Shinohara, JOURNAL OF UROLOGY, 203, E686, E686, Apr. 2020
English, Summary international conference - LATE RECURRENCE OF NON-MUSCLE-INVASIVE BLADDER CANCER AFTER A 5-YEAR CANCER-FREE PERIOD
Yurie Hirata, Takahiro Osawa, Madoka Higuchi, Shiro Hinotsu, Toru Harabayashi, Tango Mochizuki, Nobuyasu Enami, Osamu Nounaka, Yuichiro Shinno, Hiroshi Kikuchi, Ryuji Matsumoto, Takashige Abe, Sachiyo Murai, Nobuo Shinohara, JOURNAL OF UROLOGY, 203, E1079, E1080, Apr. 2020
English, Summary international conference - THE EFFECTIVENESS OF TEMPLATE-BASED REGIONAL LYMPH NODE DISSECTION IN REDUCING LOCOREGIONAL RECURRENCE IN PATIENTS WITH CLINICALLY NODE-NEGATIVE UPPER URINARY TRACT UROTHELIAL CARCINOMA
Ryuji Matsumoto, Takashige Abe, Noritaka Takada, Keita Minami, Toru Harabayashi, Satoru Maruyama, Hiroshi Kikuchi, Takahiro Osawa, Nobuo Shinohara, JOURNAL OF UROLOGY, 203, E375, E376, Apr. 2020
English, Summary international conference - URINARY EXTRACELLULAR VESICLE RNA BIOMARKERS FOR HIGH-RISK NON-MUSCLE INVASIVE BLADDER CANCER
Keita Minami, Takahiro Osawa, Taku Murakami, Hiroshi Harada, Toru Harabayashi, Norikata Takada, Akira Kashiwagi, Kazushi Hirakawa, Yasuyuki Sato, Ryuji Matsumoto, Hiroshi Kikuchi, Takashige Abe, Sachiyo Murai, Nobuo Shinohara, JOURNAL OF UROLOGY, 203, E1008, E1009, Apr. 2020
English, Summary international conference - HEALTH-RELATED QUALITY OF LIFE IN JAPANESE PATIENTS WITH BLADDER CANCER ACCORDING TO A NEWLY DEVELOPED JAPANESE VERSION OF THE BLADDER CANCER INDEX
Takahiro Osawa, John T. Wei, Takashige Abe, Shuhei Yamada, Jun Furumido, Hiroshi Kikuchi, Ryuji Matsumoto, Yoshihiro Sasaki, Kazushi Hirakawa, Akira Kashiwagi, Ken Morita, Hiroshi Tanaka, Keita Minami, Norikata Takada, Toru Harabayashi, Sachiyo Murai, Nobuo Shinohara, JOURNAL OF UROLOGY, 203, E355, E355, Apr. 2020
English, Summary international conference - 尿管ステント抜去による総腸骨動脈尿管瘻に対しVIABAHN留置を施行した1例
木野田 直也, 阿保 大介, 曽山 武士, 森田 亮, 吉野 裕紀, 工藤 與亮, 松本 隆児, 安部 崇重, 篠原 信雄, 日本インターベンショナルラジオロジー学会雑誌, 34, 4, 297, 297, Apr. 2020
(一社)日本インターベンショナルラジオロジー学会, Japanese - Health-related quality of life in Japanese patients with bladder cancer according to a newly developed Japanese version of the Bladder Cancer Index
Takahiro Osawa, John Wei, Takashige Abe, Shuhei Yamada, Jun Frumido, Haruka Miyata, Hiroshi Kikuchi, Ryuji Matsumoto, Yasuyuki Sato, Kazushi Hirakawa, Yoshihiro Sasaki, Hiroshi Tanaka, Akira Kashiwagi, Ken Morita, Norikata Takada, Keita Minami, Toru Harabayashi, Sachiyo Murai, Nobuo Shinohara, JOURNAL OF CLINICAL ONCOLOGY, 38, 6, Feb. 2020
English, Summary international conference - Experience of the surgical training course on Thiel-embalmed Cadavers.
今雅史, 安部崇重, 黒沢瞭, 守田卓人, 堀寛太, 樋口まどか, 古御堂純, 岩原直也, 菊地央, 松本隆児, 篠原信雄, 日本泌尿器科学会総会(Web), 108th, 2020 - 腹腔鏡下腎尿管全摘除術におけるリンパ節郭清術
安部崇重, 菊地央, 松本隆児, 大澤崇宏, 篠原信雄, 日本泌尿器内視鏡学会(Web), 34th, 2020 - 褐色細胞腫に対する腹腔鏡下手術
加藤諒, 安部崇重, 菊地央, 松本隆児, 大澤崇宏, 篠原信雄, 日本泌尿器内視鏡学会(Web), 34th, 2020 - 化学放射線治療後の転移性副腎腫瘍に対し腹腔鏡下副腎摘除術を施行した1例
山形優友, 安部崇重, 菊池央, 松本隆児, 大澤崇宏, 篠原信雄, 日本泌尿器内視鏡学会(Web), 34th, 2020 - 鏡視下腎部分切除における阻血法の違いによる術後腎機能の比較検討
松本隆児, 山田修平, 古御堂純, 森口卓哉, 菊地央, 大澤崇宏, 安部崇重, 篠原信雄, 日本泌尿器内視鏡学会(Web), 34th, 2020 - 筋層浸潤性膀胱癌に対する膀胱温存治療後患者のHealth-related quality of life
大澤崇宏, 安部崇重, 西岡健太郎, 菊地央, 松本隆児, 橋本孝之, 清水伸一, 青山英史, 村井祥代, 篠原信雄, 日本泌尿器内視鏡学会(Web), 34th, 2020 - 腎神経内分泌腫瘍による異所性ACTH症候群の一例
柴山 惟, 亀田 啓, 中村 昭伸, 三好 秀明, 秋川 和聖, 安部 崇重, 坪内 駿, 菊地 央, 松本 隆児, 大澤 崇宏, 篠原 信雄, 土井 和尚, 高桑 恵美, 笹野 公伸, 渥美 達也, 日本内分泌学会雑誌, 95, 2, 765, 765, Oct. 2019
(一社)日本内分泌学会, Japanese - 二分脊椎症の定期検査で早期発見し得た腎腫瘍の一例
築山 真由子, 橘田 岳也, 千葉 博基, 樋口 まどか, 中村 美智子, 今 雅史, 安部 崇重, 大澤 崇宏, 松本 隆児, 菊地 央, 篠原 信雄, 日本排尿機能学会誌, 30, 1, 257, 257, Sep. 2019
(一社)日本排尿機能学会, Japanese - 監視療法における遺伝子アッセイの有用性
丸山 覚, 森口 卓哉, 高田 徳容, 原林 透, 菊地 央, 松本 隆児, 大澤 崇宏, 安部 崇重, 永森 聡, 篠原 信雄, 泌尿器外科, 32, 8, 1019, 1021, Aug. 2019
医学図書出版(株), Japanese - ニボルマブが奏功したSarcomatoid changeを伴う淡明腎細胞癌の1症例
菊地 央, 古御堂 純, 宮田 遥, 松本 隆児, 大澤 崇宏, 安部 崇重, 篠原 信雄, 腎癌研究会会報, 49, 60, 60, Jul. 2019
腎癌研究会, Japanese - 外科的治療を先行した高齢者性腺外胚細胞腫瘍の1例
古御堂 純, 大澤 崇宏, 菊地 央, 松本 隆児, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 7, 975, 975, Jul. 2019
医学図書出版(株), Japanese - 当院におけるロボット支援腎部分切除術の臨床的検討
松本 隆児, 古御堂 純, 菊地 央, 大澤 崇宏, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 7, 980, 980, Jul. 2019
医学図書出版(株), Japanese - 膀胱悪性腫瘍に対して腹腔鏡下膀胱部分切除術を施行した2例
前田 啓介, 古御堂 純, 安部 崇重, 菊地 央, 松本 隆児, 大澤 崇宏, 篠原 信雄, 泌尿器外科, 32, 7, 981, 981, Jul. 2019
医学図書出版(株), Japanese - アビラテロン投与症例における効果予測因子の検討
丸山 覚, 森口 卓哉, 高田 徳容, 原林 透, 菊地 央, 松本 隆児, 大澤 崇宏, 安部 崇重, 篠原 信雄, 永森 聡, 泌尿器外科, 32, 7, 982, 982, Jul. 2019
医学図書出版(株), Japanese - 筋層非浸潤膀胱癌の晩期再発リスク因子の検討
樋口 まどか, 大澤 崇宏, 平田 由里絵, 宮田 遥, 菊池 央, 松本 隆児, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 7, 983, 983, Jul. 2019
医学図書出版(株), Japanese - cT1腎癌に対する開腹腎部分切除術と鏡視下腎部分切除術後のSF-36を用いたQOLの比較
大澤 崇宏, 安部 崇重, 菊地 央, 松本 隆児, 宮島 直人, 土屋 邦彦, 丸山 覚, 伊藤 陽一, 村井 祥代, 篠原 信雄, 泌尿器外科, 32, 7, 985, 986, Jul. 2019
医学図書出版(株), Japanese - 80歳以上の腎部分切除術の検討
古御堂 純, 大澤 崇宏, 菊地 央, 松本 隆児, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 7, 986, 986, Jul. 2019
医学図書出版(株), Japanese - カバジタキセルの治療成績
丸山 覚, 森口 卓哉, 高田 徳容, 原林 透, 永森 聡, 菊地 央, 松本 隆児, 大澤 崇宏, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 7, 990, 990, Jul. 2019
医学図書出版(株), Japanese - Bladder Cancer Index(BCI)日本語版の妥当性検証
古御堂 純, 大澤 崇宏, 伊藤 陽一, 菊地 央, 松本 隆児, 平川 和志, 佐藤 泰之, 佐々木 芳浩, 高田 徳容, 原林 透, 柏木 明, 田中 博, 三浪 圭太, 森田 研, 山田 修平, 村井 祥代, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 7, 991, 991, Jul. 2019
医学図書出版(株), Japanese - 当科で行っているブタ臓器を用いた腹腔鏡手術トレーニングの紹介
安部 崇重, 樋口 まどか, 宮田 遥, 今 雅史, 堀田 記世彦, 森田 研, 菊池 央, 松本 隆児, 大澤 崇宏, 倉島 庸, 篠原 信雄, 泌尿器外科, 32, 7, 992, 992, Jul. 2019
医学図書出版(株), Japanese - ニボルマブが奏功したSarcomatoid changeを伴う淡明腎細胞癌の1症例
菊地 央, 古御堂 純, 宮田 遥, 松本 隆児, 大澤 崇宏, 安部 崇重, 篠原 信雄, 腎癌研究会会報, 49, 60, 60, Jul. 2019
腎癌研究会, Japanese - 後腹膜パラガングリオーマに対する集学的治療後、WDHA症候群(Water diarrhea,Hypokalemia,Achlorhydria)を呈した1例
村橋 範浩, 安部 崇重, 松本 隆児, 大澤 崇宏, 吉永 恵一郎, 志賀 哲, 畑中 佳奈子, 松野 吉宏, 篠原 信雄, 泌尿器科紀要, 65, 7, 277, 282, Jul. 2019
泌尿器科紀要刊行会, Japanese - 外科的治療を先行した高齢者性腺外胚細胞腫瘍の1例
古御堂 純, 大澤 崇宏, 菊地 央, 松本 隆児, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 7, 975, 975, Jul. 2019
医学図書出版(株), Japanese - 当院におけるロボット支援腎部分切除術の臨床的検討
松本 隆児, 古御堂 純, 菊地 央, 大澤 崇宏, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 7, 980, 980, Jul. 2019
医学図書出版(株), Japanese - 膀胱悪性腫瘍に対して腹腔鏡下膀胱部分切除術を施行した2例
前田 啓介, 古御堂 純, 安部 崇重, 菊地 央, 松本 隆児, 大澤 崇宏, 篠原 信雄, 泌尿器外科, 32, 7, 981, 981, Jul. 2019
医学図書出版(株), Japanese - アビラテロン投与症例における効果予測因子の検討
丸山 覚, 森口 卓哉, 高田 徳容, 原林 透, 菊地 央, 松本 隆児, 大澤 崇宏, 安部 崇重, 篠原 信雄, 永森 聡, 泌尿器外科, 32, 7, 982, 982, Jul. 2019
医学図書出版(株), Japanese - 筋層非浸潤膀胱癌の晩期再発リスク因子の検討
樋口 まどか, 大澤 崇宏, 平田 由里絵, 宮田 遥, 菊池 央, 松本 隆児, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 7, 983, 983, Jul. 2019
医学図書出版(株), Japanese - cT1腎癌に対する開腹腎部分切除術と鏡視下腎部分切除術後のSF-36を用いたQOLの比較
大澤 崇宏, 安部 崇重, 菊地 央, 松本 隆児, 宮島 直人, 土屋 邦彦, 丸山 覚, 伊藤 陽一, 村井 祥代, 篠原 信雄, 泌尿器外科, 32, 7, 985, 986, Jul. 2019
医学図書出版(株), Japanese - 80歳以上の腎部分切除術の検討
古御堂 純, 大澤 崇宏, 菊地 央, 松本 隆児, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 7, 986, 986, Jul. 2019
医学図書出版(株), Japanese - カバジタキセルの治療成績
丸山 覚, 森口 卓哉, 高田 徳容, 原林 透, 永森 聡, 菊地 央, 松本 隆児, 大澤 崇宏, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 7, 990, 990, Jul. 2019
医学図書出版(株), Japanese - Bladder Cancer Index(BCI)日本語版の妥当性検証
古御堂 純, 大澤 崇宏, 伊藤 陽一, 菊地 央, 松本 隆児, 平川 和志, 佐藤 泰之, 佐々木 芳浩, 高田 徳容, 原林 透, 柏木 明, 田中 博, 三浪 圭太, 森田 研, 山田 修平, 村井 祥代, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 7, 991, 991, Jul. 2019
医学図書出版(株), Japanese - 当科で行っているブタ臓器を用いた腹腔鏡手術トレーニングの紹介
安部 崇重, 樋口 まどか, 宮田 遥, 今 雅史, 堀田 記世彦, 森田 研, 菊池 央, 松本 隆児, 大澤 崇宏, 倉島 庸, 篠原 信雄, 泌尿器外科, 32, 7, 992, 992, Jul. 2019
医学図書出版(株), Japanese - 風雲!膀胱がんの診断・治療の最前線 筋層非浸潤性膀胱癌の治療成績向上のために
大澤 崇宏, 安部 崇重, 松本 隆児, 篠原 信雄, 泌尿器外科, 32, 臨増, 612, 612, Jun. 2019
医学図書出版(株), Japanese - 上部尿路上皮がんにおけるリンパ節郭清の意義 上部尿路上皮癌におけるリンパ節郭清の意義 腹腔鏡によるリンパ節郭清の妥当性
安部 崇重, 松本 隆児, 高田 徳容, 三浪 圭太, 原林 透, 菊地 央, 大澤 崇宏, 丸山 覚, 永森 聡, 近藤 恒徳, 田邉 一成, 篠原 信雄, 泌尿器外科, 32, 臨増, 656, 657, Jun. 2019
医学図書出版(株), Japanese - 筋層非浸潤膀胱癌の晩期再発の検討
樋口 まどか, 大澤 崇宏, 宮田 遥, 菊池 央, 松本 隆児, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 臨増, 746, 746, Jun. 2019
医学図書出版(株), Japanese - 風雲!膀胱がんの診断・治療の最前線 筋層非浸潤性膀胱癌の治療成績向上のために
大澤 崇宏, 安部 崇重, 松本 隆児, 篠原 信雄, 泌尿器外科, 32, 臨増, 612, 612, Jun. 2019
医学図書出版(株), Japanese - 上部尿路上皮がんにおけるリンパ節郭清の意義 上部尿路上皮癌におけるリンパ節郭清の意義 腹腔鏡によるリンパ節郭清の妥当性
安部 崇重, 松本 隆児, 高田 徳容, 三浪 圭太, 原林 透, 菊地 央, 大澤 崇宏, 丸山 覚, 永森 聡, 近藤 恒徳, 田邉 一成, 篠原 信雄, 泌尿器外科, 32, 臨増, 656, 657, Jun. 2019
医学図書出版(株), Japanese - 筋層非浸潤膀胱癌の晩期再発の検討
樋口 まどか, 大澤 崇宏, 宮田 遥, 菊池 央, 松本 隆児, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 臨増, 746, 746, Jun. 2019
医学図書出版(株), Japanese - 系統的所属リンパ節郭清が施行された上部尿路上皮癌症例における腹腔鏡下、あるいは開放腎尿管全摘除術後の予後に関する比較研究〜後ろ向き国内共同研究
安部 崇重, 近藤 恒徳, 原林 透, 高田 徳容, 松本 隆児, 佐澤 陽, 大澤 崇宏, 三浪 圭太, 永森 聡, 宮島 直人, 土屋 邦彦, 丸山 覚, 村井 祥代, 田邊 一成, 篠原 信雄, 泌尿器外科, 32, 5, 508, 508, May 2019
医学図書出版(株), Japanese - 当科におけるアビラテロン投与例の検討 血清テストステロン値の推移
丸山 覚, 宮田 遙, 菊地 央, 大澤 崇宏, 松本 隆児, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 5, 508, 508, May 2019
医学図書出版(株), Japanese - チェックリスト導入によるTURBTの詳細な術中記録の試み
大澤 崇宏, 宮田 遙, 菊地 央, 松本 隆児, 宮島 直人, 土屋 邦彦, 丸山 覚, 安部 崇重, 村井 祥代, 篠原 信雄, 泌尿器外科, 32, 5, 513, 513, May 2019
医学図書出版(株), Japanese - Bladder Cancer Index(BCI)日本語版の開発におけるPilot Study
大澤 崇宏, Wei John T, 伊藤 陽一, 成田 学, 賀古 勇輝, 宮田 遙, 菊地 央, 松本 隆児, 宮島 直人, 丸山 覚, 安部 崇重, 村井 祥代, 篠原 信雄, 泌尿器外科, 32, 5, 518, 518, May 2019
医学図書出版(株), Japanese - 筋層非浸潤性膀胱癌ガイドラインに対する日常診療のアドヒアランスに関する調査研究
大堀 加奈子, 大澤 崇宏, 宮田 遥, 菊地 央, 松本 隆児, 丸山 覚, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 5, 519, 519, May 2019
医学図書出版(株), Japanese - 当院における前立腺癌監視療法の成績
丸山 覚, 宮田 遥, 菊地 央, 松本 隆児, 大澤 崇宏, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 5, 520, 520, May 2019
医学図書出版(株), Japanese - 前立腺癌監視療法におけるゲノムアッセイの有用性
丸山 覚, 宮田 遥, 菊地 央, 松本 隆児, 大澤 崇宏, 安部 崇重, 篠原 信雄, 泌尿器外科, 32, 5, 520, 520, May 2019
医学図書出版(株), Japanese - RENAL NEPHROMETRY SCORE CORRELATED WITH TUMOR PROLIFERATIVE ACTIVITY OF T1 CLEAR CELL RENAL CELL CARCINOMA
Hiroshi Kikuchi, Takashige Abe, Ryuji Matsumoto, Jun Furumido, Haruka Miyata, Takahiro Osawa, Sachiyo Murai, Nobuo Shinohara, JOURNAL OF UROLOGY, 201, 4, E274, E275, Apr. 2019
English, Summary international conference - COMPARISON OF LONG-TERM OUTCOMES BETWEEN RADICAL PROSTATECTOMY AND INTENSITY-MODULATED RADIATION THERAPY FOR HIGH-RISK LOCALIZED PROSTATE CANCER: A SINGLE-CENTER PROPENSITY SCORE-MATCHED ANALYSIS
Ryuji Matsumoto, Satoru Maruyama, Jun Furumido, Haruka Miyata, Hiroshi Kikuchi, Takahiro Osawa, Takashige Abe, Nobuo Shinohara, JOURNAL OF UROLOGY, 201, 4, E1059, E1060, Apr. 2019
English, Summary international conference - 進行性腎細胞癌における治療の現状と今後の展望 免疫チェックポイント阻害療法時代における分子標的療法の役割とは?
大澤 崇宏, 古御堂 純, 宮田 遥, 菊地 央, 松本 隆児, 安部 崇重, 篠原 信雄, 日本泌尿器科学会総会, 107回, SY16, 2, Apr. 2019
(一社)日本泌尿器科学会総会事務局, Japanese - 尿路上皮癌におけるリンパ郭清の意義 腹腔鏡下・ロボット支援下のリンパ節郭清の現状
安部 崇重, 古御堂 純, 宮田 遥, 菊地 央, 松本 隆児, 大澤 崇宏, 篠原 信雄, 日本泌尿器科学会総会, 107回, SY25, 4, Apr. 2019
(一社)日本泌尿器科学会総会事務局, Japanese - ブタティッシュを用いた腹腔鏡手術トレーニングのアセスメントツールとしての有用性の報告
安部 崇重, 樋口 まどか, 宮田 遙, 今 雅史, 堀田 記世彦, 森田 研, 菊地 央, 松本 隆児, 大澤 崇宏, 倉島 庸, 村井 祥代, 篠原 信雄, 日本泌尿器科学会総会, 107回, AOP, 025, Apr. 2019
(一社)日本泌尿器科学会総会事務局, Japanese - Bladder Cancer Index(BCI)日本語版の妥当性検証
大澤 崇宏, 伊藤 陽一, 古御堂 純, 菊地 央, 松本 隆児, 平川 和志, 佐々木 芳浩, 高田 徳容, 三浪 圭太, 原林 透, 村井 祥代, 安部 崇重, 篠原 信雄, 日本泌尿器科学会総会, 107回, AOP, 071, Apr. 2019
(一社)日本泌尿器科学会総会事務局, Japanese - T1淡明細胞型腎細胞癌におけるRENAL nephrometry scoreと腫瘍増殖能の関連
菊地 央, 安部 崇重, 松本 隆児, 古御堂 純, 宮田 遥, 大澤 崇宏, 篠原 信雄, 日本泌尿器科学会総会, 107回, OP, 038, Apr. 2019
(一社)日本泌尿器科学会総会事務局, Japanese - 高リスク限局性前立腺癌に対する前立腺全摘除術と放射線療法の長期治療成績の比較検討
松本 隆児, 丸山 覚, 古御堂 純, 菊地 央, 宮田 遥, 大澤 崇宏, 安部 崇重, 篠原 信雄, 日本泌尿器科学会総会, 107回, OP, 102, Apr. 2019
(一社)日本泌尿器科学会総会事務局, Japanese - アビラテロン治療効果に与える前治療の影響
丸山 覚, 森口 卓哉, 高田 徳容, 原林 透, 永森 聡, 菊地 央, 松本 隆児, 大澤 崇宏, 安部 崇重, 篠原 信雄, 日本泌尿器科学会総会, 107回, OP, 341, Apr. 2019
(一社)日本泌尿器科学会総会事務局, Japanese - 進行性腎癌に対するニボルマブの使用経験
丸山 覚, 森口 卓哉, 高田 徳容, 原林 透, 永森 聡, 日下部 直久, 佐澤 陽, 宮田 遙, 菊地 央, 松本 隆児, 大澤 崇宏, 安部 崇重, 篠原 信雄, 日本泌尿器科学会総会, 107回, OP, 458, Apr. 2019
(一社)日本泌尿器科学会総会事務局, Japanese - 当院におけるニボルマブの初期治療成績
古御堂 純, 大澤 崇宏, 宮田 遥, 菊地 央, 松本 隆児, 安部 崇重, 篠原 信雄, 日本泌尿器科学会総会, 107回, OP, 463, Apr. 2019
(一社)日本泌尿器科学会総会事務局, Japanese - 前立腺癌治療の新たな展開:ハイリスク前立腺癌に対する拡大手術、粒子線治療、ネオアジュバント治療 ハイリスク前立腺がんに対する強度変調放射線治療・陽子線治療 現状と可能性
清水 伸一, 橋本 孝之, 西岡 健太郎, 安部 崇重, 大澤 崇宏, 松本 隆児, 松浦 妙子, 宮本 直樹, 高尾 聖心, 鈴木 隆介, 梅垣 菊男, 篠原 信雄, 白土 博樹, 日本癌治療学会学術集会抄録集, 56回, SY5, 2, Oct. 2018
(一社)日本癌治療学会, English - ハイリスク筋層非浸潤性膀胱癌の治療戦略 ハイリスクNMIBCに対するBCG膀注療法
安部 崇重, 菊地 央, 松本 隆児, 大澤 崇弘, 篠原 信雄, 日本癌治療学会学術集会抄録集, 56回, PD16, 2, Oct. 2018
(一社)日本癌治療学会, English - 尿路上皮癌における抗癌剤治療後の腫瘍血管ABCB1発現亢進と薬剤耐性
菊地 央, 間石 奈湖, 宮田 遥, 松本 隆児, 大澤 孝宏, 安部 崇重, 樋田 泰浩, 丸山 覚, 原林 透, 飴田 要, 柏木 明, 松野 吉宏, 篠原 信雄, 樋田 京子, 日本癌治療学会学術集会抄録集, 56回, O22, 3, Oct. 2018
(一社)日本癌治療学会, English - 腎全摘除術と腎部分切除術が施行された限局性腎癌(cT1)患者の術後QOL比較前向き研究
大澤 崇宏, 安部 崇重, 古御堂 純, 宮田 遥, 菊地 央, 松本 隆児, 宮島 直人, 土屋 邦彦, 丸山 覚, 伊藤 陽一, 村井 幸代, 篠原 信雄, 日本癌治療学会学術集会抄録集, 56回, O42, 6, Oct. 2018
(一社)日本癌治療学会, English - 前立腺癌監視療法における不安と抑うつの評価
丸山 覚, 松本 隆児, 大澤 崇宏, 安部 崇重, 森口 卓哉, 高田 徳容, 原林 透, 永森 聡, 篠原 信雄, 日本癌治療学会学術集会抄録集, 56回, O44, 5, Oct. 2018
(一社)日本癌治療学会, English - 腹腔鏡下およびロボット支援下腎部分切除術におけるtrifecta、pentafecta達成率の検討
松本 隆児, 古御堂 純, 宮田 遥, 菊地 央, 大澤 崇宏, 丸山 覚, 安部 崇重, 篠原 信雄, 日本癌治療学会学術集会抄録集, 56回, P33, 6, Oct. 2018
(一社)日本癌治療学会, English - 当院における転移性腎細胞癌に対するアキシチニブの治療成績
日下部 直久, 大澤 崇宏, 宮田 遥, 菊地 央, 松本 隆児, 丸山 覚, 安部 崇重, 篠原 信雄, 泌尿器科紀要, 64, 9, 353, 358, Sep. 2018
泌尿器科紀要刊行会, Japanese - 【老年医学(下)-基礎・臨床研究の最新動向-】高齢者の臓器別疾患 泌尿器疾患 腎癌
大澤 崇宏, 安部 崇重, 菊地 央, 松本 隆児, 宮島 直人, 篠原 信雄, 日本臨床, 76, 増刊7 老年医学(下), 463, 467, Aug. 2018
(株)日本臨床社, Japanese - irAE Nivolumab使用中に免疫関連有害事象(irAE)を経験した転移性腎癌の2例
宮田 遥, 大澤 崇宏, 松本 隆児, 丸山 覚, 安部 崇重, 篠原 信雄, 腎癌研究会会報, 48, 28, 28, Jul. 2018
腎癌研究会, Japanese - 北海道大学病院での腎細胞癌患者に対するAxitinibの治療成績の検討
日下部 直久, 大澤 崇宏, 宮田 遥, 菊地 央, 松本 隆児, 丸山 覚, 安部 崇重, 篠原 信雄, 腎癌研究会会報, 48, 58, 58, Jul. 2018
腎癌研究会, Japanese - 進行腎細胞がん患者におけるS-1の使用経験
大澤 崇宏, 松本 隆児, 宮島 直人, 丸山 覚, 安部 崇重, 篠原 信雄, 腎癌研究会会報, 48, 109, 109, Jul. 2018
腎癌研究会, Japanese - mRCCに対する治療戦略 転移巣に対する手術療法
丸山 覚, 宮田 遥, 松本 隆児, 大澤 崇宏, 安部 崇重, 篠原 信雄, 泌尿器外科, 31, 臨増, 694, 695, Jun. 2018
医学図書出版(株), Japanese - 非セミノーマ精巣腫瘍に対するゲムシタビン/オキサリプラチン療法中に肝静脈閉塞症を発症した1例
氏橋 一紘, 宮島 直人, 森口 卓哉, 西村 陽子, 菊地 央, 広瀬 貴行, 松本 隆児, 大澤 崇宏, 丸山 覚, 安部 崇重, 篠原 信雄, 泌尿器外科, 31, 臨増, 845, 845, Jun. 2018
医学図書出版(株), Japanese - 前立腺癌監視療法におけるゲノムアッセイの有用性(第1報)
丸山 覚, 宮田 遥, 菊地 央, 松本 隆児, 大澤 崇宏, 安部 崇重, 篠原 信雄, 日本泌尿器科学会総会, 106回, OP, 247, Apr. 2018
(一社)日本泌尿器科学会総会事務局, Japanese - 前立腺癌監視療法における不安と抑うつの評価
丸山 覚, 宮田 遥, 菊地 央, 松本 隆児, 大澤 崇宏, 安部 崇重, 篠原 信雄, 日本泌尿器科学会総会, 106回, OP, 248, Apr. 2018
(一社)日本泌尿器科学会総会事務局, Japanese - 北海道大学病院での腎癌に対するAxitinibの治療成績
日下部 直久, 大澤 崇宏, 菊地 央, 松本 隆児, 丸山 覚, 安部 崇重, 篠原 信雄, 日本泌尿器科学会総会, 106回, OP, 464, Apr. 2018
(一社)日本泌尿器科学会総会事務局, Japanese - 上部尿路癌に対する腹腔鏡下腎尿管全摘除術によるリンパ節転移陽性症例の検討
松本 隆児, 安部 崇重, 高田 徳容, 三浪 圭太, 原林 透, 永森 聡, 宮田 遥, 菊地 央, 大澤 崇宏, 丸山 覚, 篠原 信雄, 日本泌尿器科学会総会, 106回, PP1, 102, Apr. 2018
(一社)日本泌尿器科学会総会事務局, Japanese - Bladder Cancer Index(BCI)日本語版の開発におけるPilot Study
大澤 崇宏, ウェイ・ジョン, 伊藤 陽一, 成田 学, 賀古 勇輝, 宮田 遙, 菊地 央, 松本 隆児, 宮島 直人, 丸山 覚, 安部 崇重, 村井 祥代, 篠原 信雄, 日本泌尿器科学会総会, 106回, PP1, 201, Apr. 2018
(一社)日本泌尿器科学会総会事務局, Japanese - 筋層非浸潤性膀胱癌ガイドラインに対する日常診療のアドヒアランスに関する調査研究
大堀 加奈子, 大澤 崇宏, 宮田 遥, 菊地 央, 松本 隆児, 丸山 覚, 安部 崇重, 篠原 信雄, 日本泌尿器科学会総会, 106回, PP1, 202, Apr. 2018
(一社)日本泌尿器科学会総会事務局, Japanese - 小径腎腫瘍に対して病理はどのように対峙すべきか 小径腎腫瘍の画像診断
大澤 崇宏, 宮田 遥, 松本 隆児, 丸山 覚, 安部 崇重, 篠原 信雄, 日本病理学会会誌, 107, 1, 244, 244, Apr. 2018
(一社)日本病理学会, Japanese - 上部尿路癌に対する腹腔鏡下腎尿管全摘除術+所属リンパ節郭清の治療成績
松本 隆児, 安部 崇重, 高田 徳容, 三浪 圭太, 原林 透, 菊地 央, 大澤 崇宏, 丸山 覚, 篠原 信雄, Japanese Journal of Endourology, 30, 3, 198, 198, Nov. 2017
(一社)日本泌尿器内視鏡学会, Japanese - チェックリスト導入によるTURBTの詳細な術中記録の試み
大澤 崇宏, 宮田 遥, 菊地 央, 松本 隆児, 宮島 直人, 土屋 邦彦, 丸山 覚, 安部 崇重, 村井 祥代, 篠原 信雄, Japanese Journal of Endourology, 30, 3, 201, 201, Nov. 2017
(一社)日本泌尿器内視鏡学会, Japanese - 転移性尿路上皮癌二次化学療法における予後因子の検討
松本 隆児, 安部 崇重, 石崎 淳司, 菊地 央, 原林 透, 三浪 圭太, 佐澤 陽, 望月 端吾, 秋野 文臣, 村雲 雅志, 大澤 崇宏, 丸山 覚, 宮田 遥, 村井 祥代, 篠原 信雄, 日本癌治療学会学術集会抄録集, 55回, P13, 3, Oct. 2017
(一社)日本癌治療学会, Japanese - 転移性腎癌に対するニボルマブの初期治療成績
宮田 遥, 大澤 崇宏, 菊地 央, 松本 隆児, 丸山 覚, 安部 崇重, 篠原 信雄, 日本癌治療学会学術集会抄録集, 55回, P33, 7, Oct. 2017
(一社)日本癌治療学会, Japanese - アビラテロン投与後に血清テストステロン値が上昇した症例の検討
丸山 覚, 宮田 遥, 菊地 央, 大澤 崇宏, 松本 隆児, 安部 崇重, 篠原 信雄, 日本癌治療学会学術集会抄録集, 55回, P80, 5, Oct. 2017
(一社)日本癌治療学会, Japanese - 抗癌剤治療前後における腫瘍血管内皮のP-glycoprotein発現変化
間石 奈湖, 菊地 央, 森本 浩史, 土屋 邦彦, 安部 崇重, 樋田 泰浩, 原林 透, 松野 吉宏, 篠原 信雄, 樋田 京子, 日本癌学会総会記事, 76回, J, 3103, Sep. 2017
日本癌学会, English - HOW TO EVALUATE THE "TRUE" DETRUSOR CONTRACTION PATTERN USING PRESSURE FLOW STUDY PARAMETERS?
M. Higuchi, T. Kitta, Y. Kanno, M. Ouchi, M. Tsukiyama, M. Togo, S. Maruyama, T. Abe, K. Moriya, N. Shinohara, NEUROUROLOGY AND URODYNAMICS, 36, S108, S110, Jul. 2017
English, Summary international conference - 進行腎細胞がん患者におけるS-1の使用経験
大澤 崇宏, 松本 隆児, 宮島 直人, 丸山 覚, 安部 崇重, 篠原 信雄, 腎癌研究会会報, 47, 46, 46, Jul. 2017
腎癌研究会, Japanese - A NEW APPROACH TO MEASURING DETRUSOR CONTRACTION PATTERN CHANGE AFTER RADICAL PROSTATECTOMY
Takeya Kitta, Yukiko Kanno, Mifuka Ouchi, Kimihiko Moriya, Satoru Maruyama, Takashige Abe, Nobuo Shinohara, JOURNAL OF UROLOGY, 197, 4, E404, E404, Apr. 2017
English, Summary international conference - 初回治療としてVEGFR-TKIが投与された有転移腎細胞がん症例に対する治療選択 ニボルマブの位置づけは?
大澤 崇宏, 菊地 央, 松本 隆児, 宮島 直人, 土屋 邦彦, 丸山 覚, 安部 崇重, 篠原 信雄, 日本泌尿器科学会総会, 105回, UP18, 2, Apr. 2017
(一社)日本泌尿器科学会総会事務局, Japanese - 尿路上皮癌における抗癌剤治療後の腫瘍血管ABCB1発現亢進
菊地央, 菊地央, 間石奈湖, 秋山廣輔, 森本真弘, 土屋邦彦, 丸山覚, 安部崇重, 樋田泰浩, 原林透, 飴田要, 松本隆児, 松本隆児, 柏木明, 松野吉宏, 篠原信雄, 樋田京子, 日本がん転移学会学術集会・総会プログラム抄録集, 26th, 134, 2017
Japanese - A MULTI-CENTER INTERNATIONAL STUDY ASSESSING THE IMPACT OF DIFFERENCES IN BASELINE CHARACTERISTICS AND PERIOPERATIVE CARE FOLLOWING RADICAL CYSTECTOMY
Takahiro Osawa, Cheryl T. Lee, Takashige Abe, Norikata Takada, Khaled S. Hafez, Jeffrey S. Montgomery, Alon Z. Weizer, Brent K. Hollenbeck, Ted A. Skolarus, Sachiyo Murai, Nobuo Shinohara, Todd M. Morgan, JOURNAL OF UROLOGY, 195, 4, E74, E75, Apr. 2016
English, Summary international conference - pT1淡明型腎細胞癌におけるRENAL nephrometry scoreとMIB-1 indexの関連
菊地 央, 安部 崇重, 松本 隆児, 宮島 直人, 土屋 邦彦, 丸山 覚, 篠原 信雄, 日本泌尿器科学会総会, 104回, PP1, 010, Apr. 2016
(一社)日本泌尿器科学会総会事務局, Japanese - 膀胱全摘術 アウトカムの改善に何が必要か? 膀胱全摘術における拡大リンパ節郭清の意義
松本 隆児, 安部 崇重, 高田 徳容, 三浪 圭太, 原林 透, 永森 聡, 宮島 直人, 土屋 邦彦, 篠原 信雄, 日本泌尿器科学会総会, 104回, FS17, 3, Apr. 2016
(一社)日本泌尿器科学会総会事務局, Japanese - 進行尿路上皮癌に対する集学的治療戦略 進行性尿路上皮癌の治療戦略 Oligometastasisに対する転移巣切除術
松本 隆児, 安部 崇重, 石崎 淳司, 大澤 崇宏, 菊地 央, 丸山 覚, 土屋 邦彦, 宮島 直人, 篠原 信雄, 日本泌尿器科学会総会, 104回, FS23, 6, Apr. 2016
(一社)日本泌尿器科学会総会事務局, Japanese - CRKアダプター蛋白質はHGF/c-Metフィードバックループを介して膀胱癌のEMTと転移を誘導する
王 磊, 松本 隆児, 津田 真寿美, 間石 奈湖, 安部 崇重, 木村 太一, 谷野 美智枝, 西原 広史, 樋田 京子, 大場 雄介, 篠原 信雄, 田中 伸哉, 日本癌学会総会記事, 74回, J, 1142, Oct. 2015
日本癌学会, English - Effectiveness of Short-term Repeated I-131 metaiodobenzylguanidine (MIBG) Radiotherapy for Preventing Disease Progression in Patients with Malignant Neuroendocrine Tumors
Keiichiro Yoshinaga, Shozo Okamoto, Tohru Shiga, Nobuo Shinohara, Takashige Abe, Yuko Uchiyama, Nagara Tamaki, JOURNAL OF NUCLEAR MEDICINE, 56, 3, May 2015
English, Summary international conference - 泌尿器科疾患治療中に生じた敗血症性肺塞栓症の2例
菊地 央, 宮島 直人, 大石 悠一郎, 池城 卓, 西村 陽子, 村橋 範浩, 広瀬 貴行, 鈴木 英孝, 今 雅史, 土屋 邦彦, 丸山 覚, 安部 崇重, 篠原 信雄, 長岡 健太郎, 泌尿器外科, 28, 5, 1005, 1005, May 2015
医学図書出版(株), Japanese - 泌尿器科疾患治療中に生じた敗血症性肺塞栓症の2例
菊地 央, 宮島 直人, 大石 悠一郎, 池城 卓, 西村 陽子, 村橋 範浩, 広瀬 貴行, 鈴木 英孝, 今 雅史, 土屋 邦彦, 丸山 覚, 安部 崇重, 篠原 信雄, 泌尿器外科, 28, 臨増, 849, 849, May 2015
医学図書出版(株), Japanese - 膀胱癌拡大リンパ節郭清に関する前向き観察研究 微小リンパ節転移の特徴
松本 隆児, 高田 徳容, 安部 崇重, 原林 透, 三浪 圭太, 永森 聡, 宮島 直人, 土屋 邦彦, 丸山 覚, 篠原 信雄, 泌尿器外科, 28, 5, 1008, 1008, May 2015
医学図書出版(株), Japanese - LAPAROSCOPIC RESECTION OF PARAAORTIC OR PARACAVAL NEUROGENIC TUMORS
Takashige Abe, Ataru Sazawa, Toru Harabayashi, Naoto Miyajima, Kunihiko Tsuchiya, Satoru Maruyama, Nobuo Shinohara, JOURNAL OF UROLOGY, 193, 4, E908, E909, Apr. 2015
English, Summary international conference - 膀胱癌転移巣におけるAldo-keto reductase(AKR)1C1の発現亢進は浸潤能と抗癌剤耐性能を反映する
松本 隆児, 津田 真寿美, 安部 崇重, 篠原 信雄, 田中 伸哉, 野々村 克也, 日本泌尿器科学会総会, 103回, 471, 471, Apr. 2015
(一社)日本泌尿器科学会総会事務局, Japanese - 3-Tesla MRIの前立腺癌検出能に関する検討
安部 崇重, 原田 太以佑, 加藤 扶美, 松本 隆児, 藤田 裕美, 丸山 覚, 土屋 邦彦, 宮島 直人, 篠原 信雄, 日本泌尿器科学会総会, 103回, 575, 575, Apr. 2015
(一社)日本泌尿器科学会総会事務局, Japanese - Treatment outcome of patients with intermediate- and poor-prognosis metastatic testicular cancer in the 2000s: A multicenter experience in Japan
Takahiro Kojima, Koji Kawai, Kunihiko Tsuchiya, Takashige Abe, Nobuo Shinohara, Toshiaki Tanaka, Naoya Masumori, Shigeyuki Yamada, Yoichi Arai, Shintaro Narita, Norihiko Tsuchiya, Tomonori Habuchi, Hiroyuki Nishiyama, JOURNAL OF CLINICAL ONCOLOGY, 33, 7, Mar. 2015
English, Summary international conference - R.E.N.A.L.nephrometry scoreは腎腫瘍無治療経過観察時における腫瘍径増大の予測因子となる
松本 隆児, 安部 崇重, 村井 祥代, 丸山 覚, 土屋 邦彦, 篠原 信雄, 野々村 克也, 泌尿器外科, 27, 12, 1968, 1968, Dec. 2014
医学図書出版(株), Japanese - 結節性硬化症に伴う腎血管筋脂肪腫に対する治療成績
宮島 直人, 鈴木 英孝, 村橋 範浩, 松本 隆児, 秋野 文臣, 土屋 邦彦, 丸山 覚, 安部 崇重, 原林 透, 篠原 信雄, 野々村 克也, 泌尿器外科, 27, 12, 1982, 1982, Dec. 2014
医学図書出版(株), Japanese - The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and crizotinib-resistant MET-driven renal tumor models
Naoto Miyajima, Tomoshige Akino, Kunihiko Tsuchiya, Satoru Maruyama, Takashige Abe, Nobuo Shinohara, Katsuya Nonomura, Len Neckers, CANCER RESEARCH, 74, 19, Oct. 2014
English, Summary international conference - 分子標的療法時代における日本人有転移腎癌の予後=JMRC分類の有用性=
篠原信雄, 小原航, 立神勝則, 内藤整, 神波大己, 高橋正幸, 村井祥代, 大庭幸治, 安部崇重, 内藤誠二, 日本癌治療学会学術集会(CD-ROM), 49, 3, 985, 985, Jun. 2014
(一社)日本癌治療学会, Japanese - High grade筋層非浸潤性膀胱癌に対する2nd TURの有用性
土屋 邦彦, 篠原 信雄, 鈴木 英孝, 村橋 範浩, 松本 隆児, 秋野 文臣, 宮島 直人, 丸山 覚, 安部 崇重, 野々村 克也, 日本癌治療学会誌, 49, 3, 1228, 1228, Jun. 2014
(一社)日本癌治療学会, Japanese - 去勢抵抗性前立腺癌骨転移例に対するゾレドロン酸の抗腫瘍効果
丸山 覚, 篠原 信雄, 鈴木 英孝, 村橋 範浩, 松本 隆児, 秋野 文臣, 宮島 直人, 土屋 邦彦, 安部 崇重, 野々村 克也, 日本癌治療学会誌, 49, 3, 2235, 2235, Jun. 2014
(一社)日本癌治療学会, Japanese - 結節性硬化症に伴う腎血管筋脂肪腫の長期治療成績
宮島 直人, 篠原 信雄, 原林 透, 鈴木 英孝, 村橋 範浩, 松本 隆児, 秋野 文臣, 土屋 邦彦, 丸山 覚, 安部 崇重, 野々村 克也, 日本癌治療学会誌, 49, 3, 2591, 2591, Jun. 2014
(一社)日本癌治療学会, Japanese - 集学的治療の後,WDHA(water diarrhea,hypokalemia,achlorhydia)症候群を呈した悪性褐色細胞腫の1例
村橋範浩, 安部崇重, 吉永恵一郎, 丸山覚, 篠原信雄, 野々村克也, 泌尿器外科, 27, 773, 15 May 2014
Japanese - Short-term repeated I-131 metaiodobenzylguanidine (MIBG) therapy prevents disease progression and reduces tumor metabolic activities in patients with malignant neuroendocrine tumors
Keiichiro Yoshinaga, Shozo Okamoto, Tohru Shiga, Nobuo Shinohara, Takashige Abe, Nagara Tamaki, JOURNAL OF NUCLEAR MEDICINE, 55, May 2014
English, Summary international conference - THE HSP90 INHIBITOR GANETESPIB SYNERGIZES WITH THE MET KINASE INHIBITOR CRIZOTINIB IN BOTH CRIZOTINIB-SENSITIVE AND CRIZOTINIB-RESISTANT MET-DRIVEN RENAL TUMOR MODELS
Naoto Miyajima, Tomoshige Akino, Kunihiko Tsuchiya, Satoru Maruyama, Takashige Abe, Nobuo Shinohara, Katsuya Nonomura, Len Neckers, JOURNAL OF UROLOGY, 191, 4, E374, E375, Apr. 2014
English, Summary international conference - 検証:R.E.N.A.L Nephrometry score R.E.N.AL. scoreおよびPADUA分類は本当に臨床的に有用か? R.E.N.A.L nephrometry score その"実用性"に関して
松本 隆児, 安部 崇重, 丸山 覚, 土屋 邦彦, 宮島 直人, 篠原 信雄, 野々村 克也, 日本泌尿器科学会総会, 102回, 373, 373, Apr. 2014
(一社)日本泌尿器科学会総会事務局, Japanese - 腎盂尿管癌における至適リンパ節郭清範囲の確立を目指した前向き観察研究
安部 崇重, 高田 徳容, 松本 隆児, 大澤 崇宏, 佐澤 陽, 丸山 覚, 土屋 邦彦, 宮島 直人, 原林 透, 三浪 圭太, 永森 聡, 篠原 信雄, 野々村 克也, 日本泌尿器科学会総会, 102回, 406, 406, Apr. 2014
(一社)日本泌尿器科学会総会事務局, Japanese - 当院において経験した副腎hemangiomaの一例
今 雅史, 土屋 邦彦, 丸山 覚, 安部 崇重, 篠原 信雄, 三井 貴彦, 山田 洋介, 野々村 克也, 泌尿器外科, 27, 2, 247, 247, Feb. 2014
医学図書出版(株), Japanese - 横紋筋肉腫様変化を伴う腎細胞癌を発症した夫婦例の経験
松本 隆児, 篠原 信雄, 土屋 邦彦, 安部 崇重, 丸山 覚, 久保田 佳奈子, 黒田 直人, 野々村 克也, 泌尿器外科, 27, 2, 255, 255, Feb. 2014
医学図書出版(株), Japanese - 化学療法を受けた尿路上皮癌患者における血栓塞栓症のリスク因子についての検討
大澤崇宏, 丸山覚, 大庭幸治, 安部崇重, 丸晋太郎, 秋野文臣, 佐澤陽, 篠原信雄, 野々村克也, 泌尿器外科, 26, 12, 1857, 1857, Dec. 2013
医学図書出版(株), Japanese - 前立腺癌骨転移患者における骨関連事象(SRE)の検討
丸山 覚, 篠原 信雄, 鈴木 英孝, 村橋 範浩, 松本 隆児, 宮島 直人, 土屋 邦彦, 安部 崇重, 佐澤 陽, 野々村 克也, 日本癌治療学会誌, 48, 3, 1488, 1488, Sep. 2013
(一社)日本癌治療学会, Japanese - 当院における非機能性副腎腫瘍の検討
今 雅史, 丸山 覚, 土屋 邦彦, 安部 崇重, 森田 研, 篠原 信雄, 野々村 克也, 泌尿器外科, 26, 臨増, 724, 724, May 2013
医学図書出版(株), Japanese - 横紋筋肉腫様変化を伴う腎細胞癌を発症した夫婦例の報告
松本 隆児, 篠原 信雄, 土屋 邦彦, 安部 崇重, 丸山 覚, 久保田 佳奈子, 黒田 直人, 野々村 克也, 泌尿器外科, 26, 臨増, 732, 732, May 2013
医学図書出版(株), Japanese - PERIOPERATIVE MORBIDITY AND MORTALITY RELATED TO RADICAL CYSTECTOMY: A MULTI-INSTITUTIONAL RETROSPECTIVE STUDY IN JAPAN
Takashige Abe, Norikata Takada, Nobuo Shinohara, Ataru Sazawa, Satoru Maruyama, Kunihiko Tsuchiya, Shino Kanzaki, Yuichiro Shinno, Soushu Sato, Kimiyoshi Mitsuhashi, Takuya Sato, Keiji Sugishita, Shinji Kamota, Takanori Yamashita, Junji Ishizaki, Takaya Hioka, Gaku Mouri, Takenori Ono, Naoto Miyajima, Takanori Sakuta, Tango Mochizuki, Toshiki Aoyagi, Hidenori Katano, Tomoshige Akino, Kazushi Hirakawa, Keita Minami, Akira Kumagai, Masaki Togashi, Toshimori Seki, Katsuya Nonomura, JOURNAL OF UROLOGY, 189, 4, E664, E664, Apr. 2013
English, Summary international conference - 高齢泌尿器癌患者の治療戦略 高齢者の小径腎腫瘍に対する治療戦略
安部 崇重, 篠原 信雄, 松本 隆児, 丸山 覚, 土屋 邦彦, 野々村 克也, 尿路悪性腫瘍研究会記録, 39, 22, 26, Apr. 2013
尿路悪性腫瘍研究会, Japanese - ダイオキシン受容体内因性リガンドによる前立腺癌細胞におけるアンドロゲンレセプター発現低下と増殖抑制
丸山覚, 築山忠維, 宮島直人, 土屋邦彦, 安部崇重, 佐澤陽, 篠原信雄, 畠山鎮次, 野々村克也, 日本泌尿器科学会雑誌, 104, 2, 415, Mar. 2013
Japanese - 肝・膵転移 (Topics of RCC : 転移巣に対する治療戦略)
篠原 信雄, 宮田 遥, 安部 崇重, Year book of RCC, 79, 86, 2013
メディカルレビュー社, Japanese - 診断に苦慮した若年者左腎嚢胞性病変の1例
SUZUKI HIDETAKA, MIYAJIMA NAOTO, TSUCHIYA KUNIHIKO, MARUYAMA SATORU, ABE TAKASHIGE, SHINOHARA NOBUO, YABUSAKI TETSUSHI, MANABE TOKUKO, KATO FUMI, NISHIDA MUTSUMI, NONOMURA KATSUYA, 泌尿器画像診断・治療技術研究会プログラム・抄録, 1st, 64, 2013
Japanese - Decreasing Acute and Late Toxicity Using Urethral Dose Reduction and Smaller Safety Margin Around CTV for Prostate Cancer Intensity Modulated Radiation Therapy (IMRT) With a Real-time Tumor-tracking (RTRT) System
S. Shimizu, K. Nishioka, R. Onimaru, R. Kinoshita, K. Harada, N. Nishikawa, T. Abe, S. Maruyama, N. Shinohara, H. Shirato, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 84, 3, S181, S181, Nov. 2012
English, Summary international conference - A new prognostic classification for overall survival in Asian patients with previously untreated metastatic renal cell carcinoma (vol 103, pg 1695, 2012)
N. Shinohara, K. Nonomura, T. Abe, S. Maruyama, T. Kamai, M. Takahashi, K. Tatsugami, S. Yokoi, T. Deguchi, H. Kanayama, K. Oba, S. Naito, CANCER SCIENCE, 103, 10, 1905, 1905, Oct. 2012
English, Others - 異時性両側性精巣腫瘍に対して一側精巣摘除術および対側精巣部分切除術を施行した1例
宮本 秀一, 篠原 信雄, 松本 隆児, 山田 洋介, 橘田 岳也, 丸山 覚, 安部 崇重, 佐澤 陽, 野々村 克也, 泌尿器外科, 25, 10, 2067, 2067, Oct. 2012
医学図書出版(株), Japanese - 当科における鏡視下前立腺全摘除術の成績
佐澤 陽, 安部 崇重, 篠原 信雄, 丸山 覚, 宮島 直人, 大澤 崇宏, 松本 隆児, 佐々木 元, 原林 透, 野々村 克也, 泌尿器外科, 25, 10, 2069, 2069, Oct. 2012
医学図書出版(株), Japanese - 鏡視下腎部分切除術 周術期合併症症例を振り返る
松本 隆児, 安部 崇重, 原林 透, 佐々木 元, 丸山 覚, 佐澤 陽, 篠原 信雄, 野々村 克也, 泌尿器外科, 25, 10, 2078, 2078, Oct. 2012
医学図書出版(株), Japanese - 精巣癌化学療法後に正常化しないβ-hCGは疑陽性の可能性がある
丸山 覚, 安部 崇重, 橘田 岳也, 宮島 直人, 岩見 大基, 松本 隆児, 佐々木 元, 菅野 由起子, 佐澤 陽, 篠原 信雄, 野々村 克也, 泌尿器外科, 25, 10, 2085, 2085, Oct. 2012
医学図書出版(株), Japanese - 悪性褐色細胞腫に対する131Imetaiodobenzylguanidine(MIBG)内照射療法
池城卓, 佐澤陽, 安部崇重, 丸山覚, 丸晋太郎, 大澤崇宏, 青柳俊紀, 篠原信雄, 吉永恵一郎, 玉木長良, 野々村克也, 泌尿器外科, 25, 9, 1910, 15 Sep. 2012
Japanese - VALIDATION STUDY OF EAU RISK GROUP STRATIFICATION IN JAPANESE PATIENTS WITH STAGE TA AND T1 INITIAL BLADDER TUMORS
Takafumi Kawazu, Takashige Abe, Hiroki Chiba, Ataru Sazawa, Satoru Maruyama, Nobuo Shinohara, Katsuya Nonomura, JOURNAL OF ENDOUROLOGY, 26, A390, A390, Sep. 2012
English, Summary international conference - LAPAROSCOPIC PARTIAL NEPHRECTOMY IN A HORSESHOE KIDNEY
Takashige Abe, Ataru Sazawa, Satoru Maruyama, Nobuo Shinohara, Katsuya Nonomura, JOURNAL OF ENDOUROLOGY, 26, A516, A516, Sep. 2012
English, Summary international conference - OUTCOME OF REPEAT TRANSURETHREL RESECTION IN PATIENTS WITH STAGE T1 GRADE 3 BLADDER CANCER
Hiroki Chiba, Takashige Abe, Takahumi Kawatsu, Ataru Sazawa, Satoru Maruyama, Nobuo Shinohara, Katsuya Nonomura, JOURNAL OF ENDOUROLOGY, 26, A88, A89, Sep. 2012
English, Summary international conference - RISK CLASSIFICATION TO PREDICT SURVIVAL AFTER CYTOREDUCTIVE NEPHRECTOMY IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA
Nobuo Shinohara, Takashige Abe, Satoru Maruyama, Ataru Sazawa, Katsuya Nonomura, JOURNAL OF UROLOGY, 187, 4, E723, E723, Apr. 2012
English, Summary international conference - IMPACT OF MTORC2-HIF-2 alpha SIGNALING PATHWAY ON THE REGULATION OF E-CADHERIN EXPRESSION OF RENAL CELL CARCINOMA CELL LINE, 786-O
Shintaro Maru, Yasuhito Ishigaki, Nobuo Shinohara, Takanobu Takata, Takashige Abe, Satoru Maruyama, Ataru Sazawa, Naohisa Tomosugi, Katsuya Nonomura, JOURNAL OF UROLOGY, 187, 4, E58, E58, Apr. 2012
English, Summary international conference - 腫瘍血管内皮におけるLysyl oxidaseの機能解析
大澤崇宏, 樋田京子, 大賀則孝, 秋山廣輔, 樋田泰浩, 丸山覚, 安部崇重, 佐澤陽, 篠原信雄, 進藤正信, 野々村克也, 日本泌尿器科学会雑誌, 103, 2, 356, 20 Mar. 2012
Japanese - Can PSA doubling time exactly predict the candidates for active surveillance in patients with low-risk prostate cancer?
Satoru Maruyama, Nobuo Shinohara, Takashige Abe, Ataru Sazawa, Katsuya Nonomura, JOURNAL OF CLINICAL ONCOLOGY, 30, 5, Feb. 2012
English, Summary international conference - Prognosis of patients with renal cell carcinoma with disease recurrence following nephrectomy for localized disease.
Nobuo Shinohara, Takashige Abe, Satoru Maruyama, Ataru Sazawa, Katsuya Nonomura, JOURNAL OF CLINICAL ONCOLOGY, 30, 5, Feb. 2012
English, Summary international conference - LAPAROSCOPIC RESECTION IN RETROPERITONEAL PARAGANGLIOMA
Ataru Sazawa, Takashige Abe, Nobuo Shinohara, Satoru Maruyama, Toru Harabayashi, Katsuya Nonomura, JOURNAL OF ENDOUROLOGY, 25, A316, A316, Nov. 2011
English, Summary international conference - 【腹腔鏡下腎部分切除】冷却併用腹腔鏡下腎部分切除術
安部 崇重, 佐澤 陽, 原林 透, 松本 隆児, 丸山 覚, 篠原 信雄, 野々村 克也, Japanese Journal of Endourology, 24, 3, 66, 66, Oct. 2011
(一社)日本泌尿器内視鏡学会, Japanese - 化学療法を受けた尿路上皮癌患者における血栓塞栓症のリスク因子についての検討
大澤崇宏, 丸山覚, 大庭幸治, 安部崇重, 丸晋太郎, 秋野文臣, 佐澤陽, 篠原信雄, 野々村克也, 日本癌治療学会誌, 46, 2, 933, 933, 13 Sep. 2011
(一社)日本癌治療学会, Japanese - 局所前立腺癌に対する治療法別健康関連QOLの長期前向き観察試験(最終報告)
篠原信雄, 丸山覚, 清水伸一, 安部崇重, 佐澤陽, 大庭幸治, 白土博樹, 野々村克也, 日本癌治療学会誌, 46, 2, 422, 13 Sep. 2011
Japanese - 進行性精巣癌化学療法後に正常化しないβ-hCGは疑陽性の可能性がある
丸山 覚, 安部 崇重, 橘田 岳也, 宮島 直人, 岩見 大基, 松本 隆児, 佐々木 元, 菅野 由起子, 佐澤 陽, 篠原 信雄, 野々村 克也, 日本癌治療学会誌, 46, 2, 712, 712, Sep. 2011
(一社)日本癌治療学会, Japanese - 【"長期成績"〜V."腎部分切除"〜】冷却併用腹腔鏡下腎部分切除術
安部 崇重, 佐澤 陽, 原林 透, 松本 隆児, 丸山 覚, 篠原 信雄, 野々村 克也, Japanese Journal of Endourology, 24, 2, 228, 232, Sep. 2011
(一社)日本泌尿器内視鏡学会, Japanese - ACCURACY AND LIMITATION OF URETEROSCOPY IN DIAGNOSIS OF UPPER URINARY TRACT CANCER
Norihiro Murahashi, Takashige Abe, Toru Harabayashi, Nobuo Shinohara, Ataru Sazawa, Satoru Maruyama, Katsuya Nonomura, JOURNAL OF UROLOGY, 185, 4, E556, E556, Apr. 2011
English, Summary international conference - 異時性両側性精巣腫瘍に対して一側精巣摘除術および対側精巣部分切除術を施行した1例
宮本 秀一, 篠原 信雄, 松本 隆児, 橘田 岳也, 丸山 覚, 安部 崇重, 佐澤 陽, 野々村 克也, 泌尿器外科, 24, 臨増, 514, 514, Apr. 2011
医学図書出版(株), Japanese - 経直腸的前立腺生検後の再生検における経会陰的アプローチの意義
佐々木 元, 安部 崇重, 丸山 覚, 松本 隆児, 宮島 直人, 佐澤 陽, 篠原 信雄, 野々村 克也, 泌尿器外科, 24, 臨増, 535, 535, Apr. 2011
医学図書出版(株), Japanese - Predictors of long-term survival in patients with metastatic renal cell carcinoma in the cytokine era: An analysis of 473 patients treated between 1995 and 2005
N. Shinohara, S. Maruyama, T. Abe, A. Sazawa, K. Nonomura, JOURNAL OF CLINICAL ONCOLOGY, 29, 7, Mar. 2011
English, Summary international conference - Low risk前立腺癌に対するPSA監視療法におけるPSA doubling timeの意義
丸山 覚, 篠原 信雄, 佐々木 元, 松本 隆児, 大澤 崇宏, 宮島 直人, 安部 崇重, 佐澤 陽, 原林 透, 野々村 克也, 日本泌尿器科学会雑誌, 102, 2, 314, 314, Mar. 2011
(一社)日本泌尿器科学会, Japanese - 進行性前立腺癌に対するドセタキセルの効果と有害事象
佐澤 陽, 篠原 信雄, 安部 崇重, 丸山 覚, 宮島 直人, 大澤 崇宏, 松本 隆児, 野々村 克也, 日本泌尿器科学会雑誌, 102, 2, 371, 371, Mar. 2011
(一社)日本泌尿器科学会, Japanese - 膀胱全摘後の遅発性再発について
安部 崇重, 篠原 信雄, 佐澤 陽, 丸山 覚, 松本 隆児, 山下 登, 信野 祐一郎, 内野 秀紀, 岡 応樹, 坂下 茂夫, 熊谷 章, 森 達也, 野々村 克也, 日本泌尿器科学会雑誌, 102, 2, 382, 382, Mar. 2011
(一社)日本泌尿器科学会, Japanese - PSA監視療法の適応基準と治療開始基準 PSA kineticsは有用か?
丸山 覚, 篠原 信雄, 佐々木 元, 松本 隆児, 大澤 崇宏, 宮島 直人, 安部 崇重, 佐澤 陽, 野々村 克也, 日本腎泌尿器疾患予防医学研究会誌, 19, 1, 89, 92, Mar. 2011
日本腎泌尿器疾患予防医学研究会, Japanese - 膀胱癌術後再発にて直腸輪状狭窄を呈した1例
加藤 健太郎, 七戸 俊明, 新田 建雄, 寺村 紘一, 那須 裕也, 楢崎 肇, 川村 武史, 中山 智英, 三浦 巧, 高田 実, 田本 英司, 寺本 賢一, 村上 壮一, 松本 譲, 土川 貴裕, 田中 栄一, 平野 聡, 近藤 哲, 安部 崇重, 佐澤 陽, 野々村 克也, 小野 尚子, 日本大腸肛門病学会雑誌, 64, 2, 100, 100, Feb. 2011
(一社)日本大腸肛門病学会, Japanese - 鏡視下腎部分切除術 周術期合併症症例を振り返る
松本 隆児, 安部 崇重, 原林 透, 佐々木 元, 丸山 覚, 佐澤 陽, 篠原 信雄, 野々村 克也, Japanese Journal of Endourology and ESWL, 23, 3, 154, 154, Oct. 2010
(一社)日本泌尿器内視鏡学会, Japanese - 鏡視下手術におけるポートサイト合併症
佐澤 陽, 安部 崇重, 篠原 信雄, 丸山 覚, 宮島 直人, 大澤 崇宏, 松本 隆児, 佐々木 元, 原林 透, 野々村 克也, Japanese Journal of Endourology and ESWL, 23, 3, 198, 198, Oct. 2010
(一社)日本泌尿器内視鏡学会, Japanese - Nephrometry Scoring Systemを用いた腹腔鏡下腎部分切除術のリスク評価
安部 崇重, 篠原 信雄, 佐澤 陽, 原林 透, 森田 研, 松本 隆児, 佐々木 元, 丸山 覚, 野々村 克也, Japanese Journal of Endourology and ESWL, 23, 3, 207, 207, Oct. 2010
(一社)日本泌尿器内視鏡学会, Japanese - ACCURACY AND LIMITATION OF URETEROSCOPY IN DIAGNOSIS OF UPPER URINARY TRACT CANCER.
N. Murahashi, T. Abe, N. Shinohara, A. Sazawa, S. Maruyama, T. Osawa, K. Nonomura, JOURNAL OF ENDOUROLOGY, 24, A322, A322, Sep. 2010
English, Summary international conference - OUTCOME OF REGIONAL LYMPH NODE DISSECTION IN CONJUNCTION WITH LAPAROSCOPIC NEPHROURETERECTOMY FOR UROTHELIAL CARCINOMA OF UPPER URINARY TRACT
H. Sasaki, T. Abe, S. Maruyama, N. Fukuzawa, A. Sazawa, T. Harabayashi, N. Shinohara, K. Nonomura, JOURNAL OF ENDOUROLOGY, 24, A373, A373, Sep. 2010
English, Summary international conference - LAPAROSCOPIC PARTIAL NEPHRECTOMY FOR ENDOPHYTIC TUMORS
R. Matsumoto, T. Abe, T. Harabayashi, S. Maruyama, A. Sazawa, N. Shinohara, K. Nonomura, JOURNAL OF ENDOUROLOGY, 24, A386, A387, Sep. 2010
English, Summary international conference - 早期前立腺がんの治療戦略 PSA監視療法の適応基準と治療開始基準 PSA kineticsの検討
丸山 覚, 篠原 信雄, 佐々木 元, 松本 隆児, 大澤 崇宏, 宮島 直人, 安部 崇重, 佐澤 陽, 野々村 克也, 日本癌治療学会誌, 45, 2, 491, 491, Sep. 2010
(一社)日本癌治療学会, Japanese - 経直腸的前立腺生検後の再生検における経会陰的アプローチの意義
佐々木 元, 安部 崇重, 松本 隆児, 宮島 直人, 丸山 覚, 佐澤 陽, 篠原 信雄, 野々村 克也, 日本癌治療学会誌, 45, 2, 837, 837, Sep. 2010
(一社)日本癌治療学会, Japanese - 鏡視下前立腺全摘除術後のPSA再発に関する因子の検討
佐澤 陽, 篠原 信雄, 安部 崇重, 丸山 覚, 宮島 直人, 大澤 崇宏, 佐々木 元, 松本 隆児, 原林 透, 野々村 克也, 日本癌治療学会誌, 45, 2, 940, 940, Sep. 2010
(一社)日本癌治療学会, Japanese - IMPACT OF INCREASED ABDOMINAL PRESSURE DURING MICTURITION ON INGUINAL HERNIA DEVELOPMENT AFTER RADICAL PROSTATECTOMY: ANALYSIS IN PRESSURE FLOW STUDY
S. Maruyama, T. Mitsui, M. Tsukiyama, K. Moriya, H. Tanaka, T. Abe, A. Sazawa, T. Harabayashi, N. Shinohara, K. Nonomura, INTERNATIONAL UROGYNECOLOGY JOURNAL, 21, S123, S124, Aug. 2010
English, Summary international conference - LONG-TERM OUTCOME OF RENAL FUNCTION IN BLADDER CANCER PATIENTS AFTER RADICAL CYSTECTOMY
Takahiro Osawa, Satoru Maruyama, Takashige Abe, Shintaro Maru, Toshiki Aoyagi, Ataru Sazawa, Nobuo Shinohara, Katsuya Nonomura, JOURNAL OF UROLOGY, 183, 4, E369, E369, Apr. 2010
English, Summary international conference - PD7-4 腎癌有転移例におけるUpfront IFNα治療の有用性(進行性腎癌に対するNeoadjuvant療法,パネルディスカッション7,第98回日本泌尿器科学会総会)
佐澤 陽, 篠原 信雄, 安部 崇重, 丸山 覚, 新藤 純理, 佐藤 聡秋, 野々村 克也, 日本泌尿器科學會雜誌, 101, 2, 20 Feb. 2010
社団法人日本泌尿器科学会, Japanese - APP-052 膀胱全摘除術に伴う尿路変向術は術後腎機能に影響を及ぼすか?(発表・討論,総会賞応募ポスター,第98回日本泌尿器科学総会)
大澤 崇宏, 丸 晋太郎, 青柳 俊紀, 丸山 覚, 安部 崇重, 佐澤 陽, 篠原 信雄, 野々村 克也, 日本泌尿器科學會雜誌, 101, 2, 20 Feb. 2010
社団法人日本泌尿器科学会, Japanese - OP-150 尿路上皮癌clinical node+症例の治療成績(膀胱腫瘍/手術1,一般演題口演,第98回日本泌尿器科学会総会)
安部 崇重, 篠原 信雄, 佐澤 陽, 丸山 覚, 原林 透, 鈴木 信, 大澤 崇宏, 丸 晋太郎, 青柳 俊紀, 石川 修平, 野々村 克也, 日本泌尿器科學會雜誌, 101, 2, 20 Feb. 2010
社団法人日本泌尿器科学会, Japanese - OP-471 preclinical Cushing症候群および非機能性副腎腫瘍の併存症(副腎・後腹膜,一般演題口演,第98回日本泌尿器科学会総会)
丸山 覚, 守屋 仁彦, 丸 晋太朗, 大澤 崇宏, 青柳 俊紀, 安部 崇重, 森田 研, 佐澤 陽, 篠原 信雄, 野々村 克也, 日本泌尿器科學會雜誌, 101, 2, 20 Feb. 2010
社団法人日本泌尿器科学会, Japanese - OP-494 分子標的療法が施行された腎癌症例におけるリスク分類の検討(腎腫瘍/薬物療法3,一般演題口演,第98回日本泌尿器科学会総会)
佐澤 陽, 篠原 信雄, 安部 崇重, 丸山 覚, 青柳 俊紀, 大澤 崇宏, 丸 晋太郎, 野々村 克也, 日本泌尿器科學會雜誌, 101, 2, 20 Feb. 2010
社団法人日本泌尿器科学会, Japanese - PP-251 放射線化学療法により延命が得られた前立腺小細胞癌の2例(発表・討論,一般演題ポスター,第98回日本泌尿器科学会総会)
菊地 央, 丸山 覚, 村橋 範浩, 丸 晋太朗, 大澤 崇宏, 青柳 俊紀, 田邉 起, 安部 崇重, 三浦 正義, 佐澤 陽, 篠原 信雄, 野々村 克也, 清水 康, 日本泌尿器科學會雜誌, 101, 2, 20 Feb. 2010
社団法人日本泌尿器科学会, Japanese - IMPACT OF INCREASED ABDOMINAL PRESSURE DURING MICTURITION ON INGUINAL HERNIA DEVELOPMENT AFTER RADICAL PROSTATECTOMY: ANALYSIS IN PRESSURE FLOW STUDY
S. Maruyama, T. Mitsui, M. Tsukiyama, K. Moriya, H. Tanaka, T. Abe, A. Sazawa, T. Harabayashi, N. Shinohara, K. Nonomura, NEUROUROLOGY AND URODYNAMICS, 29, 6, 927, 928, 2010
English, Summary international conference - Role of lymph node dissection in the treatment of urothelial carcinoma of the upper urinary tract: Multi-institutional relapse analysis and immunohistochemical re-evaluation of negative lumph nodes.
ABE T, SHINOHARA N, MURANAKA M, SAZAWA A, MARUYAMA S, OSAWA T, NONOMURA K, HARABAYASHI T, SHIBATA T, TOYADA Y, SHINNO Y, MINAMI K, SAKASHITA S, KUMAGAI A, TAKADA N, TOGASHI M, SANO H, MORI T, KUBOTA K, MATSUNO Y, EJSO, 36, 11, 1085, 1091, 2010 - 腎癌患者へのSunitinib投与が引き起こす甲状腺機能障害の発症機序
篠原 信雄, 高橋 正幸, 神島 保, 生島 仁史, 大塚 紀幸, 石津 明洋, 丸山 覚, 安部 崇重, 佐澤 陽, 金山 博臣, 野々村 克也, 日本癌治療学会誌, 44, 2, 456, 456, Sep. 2009
(一社)日本癌治療学会, Japanese - Clinical outcome of laparoscopic partial nephrectomy
佐澤 陽, 安部 崇重, 篠原 信雄, 丸山 覚, 原林 透, 野々村 克也, Jpn J Endourol ESWL, 22, 2, 234, 238, 01 Sep. 2009
Japanese - TRIM68 REGULATES LIGAND-DEPENDENT TRANSCRIPTION OF ANDROGEN RECEPTOR IN PROSTATE CANCER CELLS
Naoto Miyajima, Satoru Maruyama, Takashige Abe, Ataru Sazawa, Nobuo Shinohara, Shigetsugu Hatakeyama, Katsuya Nonomura, JOURNAL OF UROLOGY, 181, 4, 398, 398, Apr. 2009
English, Summary international conference - POTENTIAL THERAPEUTIC ROLE OF LYMPH NODE DISSECTION IN TREATMENT OF UPPER URINARY TRACT CANCER: IMMUNOHISTOCHEMICAL ANALYSIS OF NEGATIVE LYMPH NODES AND PROGNOSTIC FACTORS OF LYMPH NODE RECURRENCE
Takashige Abe, Nobuo Shinohara, Ataru Sazawa, Satoru Maruyama, Toru Harabayashi, Kanako Kubota, Yoshihiro Matsuno, Takeshi Shibata, Yutaka Toyoda, Yuichiro Shinno, Keita Minami, Shigeo Sakashita, Akira Kumagai, Norikata Takada, Masaki Togashi, Hiroshi Sano, Tatsuya Mori, Katsuya Nonomura, JOURNAL OF UROLOGY, 181, 4, 134, 134, Apr. 2009
English, Summary international conference - POTENTIAL THERAPEUTIC ROLE OF LYMPH NODE DISSECTION IN TREATMENT OF UPPER URINARY TRACT CANCER: IMMUNOHISTOCHEMICAL ANALYSIS OF NEGATIVE LYMPH NODES AND PROGNOSTIC FACTORS OF LYMPH NODE RECURRENCE
T. Abe, N. Shinohara, A. Sazawa, S. Maruyama, T. Harabayashi, K. Kubota, Y. Matsuno, T. Shibata, Y. Toyada, Y. Shinno, K. Minami, S. Sakashita, A. Kumagai, N. Takada, M. Togashi, H. Sano, T. Mori, K. Nonomura, EUROPEAN UROLOGY SUPPLEMENTS, 8, 4, 149, 149, Mar. 2009
English, Summary international conference - OP-097 根治的前立腺全摘術後の鼠径ヘルニアは術後排尿時腹圧の上昇のためか?(前立腺腫瘍/手術3,一般演題口演,第97回日本泌尿器科学会総会)
丸山 覚, 安部 崇重, 三井 貴彦, 守屋 仁彦, 田中 博, 佐澤 陽, 原林 透, 篠原 信雄, 野々村 克也, 日本泌尿器科學會雜誌, 100, 2, 20 Feb. 2009
社団法人日本泌尿器科学会, Japanese - OP-042 当院における褐色細胞腫に対する鏡視下及び開腹手術の比較検討(副腎・後腹膜,一般演題口演,第97回日本泌尿器科学会総会)
広瀬 貴行, 原林 透, 安部 崇重, 丸山 覚, 三浦 正義, 佐澤 陽, 篠原 信雄, 野々村 克也, 日本泌尿器科學會雜誌, 100, 2, 20 Feb. 2009
社団法人日本泌尿器科学会, Japanese - APP-036-PM 腎盂尿管腫瘍におけるリンパ節郭清の治療的意義(総会賞応募ポスター,第97回日本泌尿器科学会総会)
安部 崇重, 篠原 信雄, 原林 透, 佐澤 陽, 丸山 覚, 柴田 武, 豊田 裕, 鴨田 慎二, 三浪 圭太, 熊谷 章, 佐野 洋, 高田 徳容, 野々村 克也, 日本泌尿器科學會雜誌, 100, 2, 20 Feb. 2009
社団法人日本泌尿器科学会, Japanese - Phase II trial of meloxicam, a COX-2 inhibitor, and interferon alfa in patients with metastatic renal cell carcinoma
N. Shinohara, T. Abe, A. Sazawa, K. Nonomura, JOURNAL OF CLINICAL ONCOLOGY, 26, 15, 16003, May 2008
English, Summary international conference - Chromosomal abnormalities of tumor endothelial cells in human renal cell carcinoma
Tomoshige Akino, Kyoko Hida, Kunihiko Tsuchiya, Yasuhiro Hida, Michael Klagsbrun, Kohei Matsuda, Noritaka Ohga, Takashige Abe, Ataru Sazawa, Toru Harabayashi, Nobuo Shinohara, Masanobu Shindoh, Katsuya Nonormura, JOURNAL OF UROLOGY, 179, 4, 133, 133, Apr. 2008
English, Summary international conference - Pathologic characteristics and clinical courses of bladder tumors after nephroureterectomy for upper urinary tract cancer
Takashige Abe, Nobuo Shinohara, Toru Harabayashi, Ataru Sazawa, Shuhei Ishikawa, Takahiro Osawa, Kanako Kubota, Yoshihiro Matsuno, Yuichiro Shinno, Shinji Kamota, Keita Minami, Shigeo Sakashita, Akira Kumagai, Tatsuya Mori, Masaki Togashi, Katsuya Nonomura, JOURNAL OF UROLOGY, 179, 4, 72, 72, Apr. 2008
English, Summary international conference - Changes of urodynamic findings and lower urinary tract symptoms after radical prostatectomy
T. Mitsui, H. Tanaka, T. Harabayashi, K. Moriya, M. Matsuda, T. Abe, A. Sazawa, N. Shinohara, T. Kitta, K. Nonomura, EUROPEAN UROLOGY SUPPLEMENTS, 7, 3, 87, 87, Mar. 2008
English, Summary international conference - Impact of nephron-sparing surgery on long-term postoperative quality of life in patients with T1 renal cell carcinoma
Nobuo Shinohara, Toru Harabayashi, Ataru Sazawa, Takashige Abe, Ichiro Takeuchi, Akira Kumagai, Akira Kashiwagi, Satoshi Nagamori, Katsuya Nonomura, JOURNAL OF UROLOGY, 177, 4, 412, 412, Apr. 2007
English, Summary international conference - Kidney and body temperature in retroperitoneoscopic partial nephrectomy using ice-slush direct injection method
T. Harabayashi, T. Abe, T. Akino, K. Morita, A. Sazawa, N. Shinohara, K. Nonomura, EUROPEAN UROLOGY SUPPLEMENTS, 6, 2, 236, 236, Mar. 2007
English, Summary international conference - APP-043 前立腺癌細胞におけるPSA分泌の制御機構の検討(第95回日本泌尿器科学会総会)
丸山 覚, 宮島 直人, 安部 崇重, 佐澤 陽, 原林 透, 篠原 信雄, 佐藤 択矢, 柏木 明, 永森 聡, 畠山 鎮次, 野々村 克也, 日本泌尿器科學會雜誌, 98, 2, 20 Feb. 2007
社団法人日本泌尿器科学会, Japanese - PP-607 前立腺癌骨転移診断における1CTPの有用性(第95回日本泌尿器科学会総会)
望月 端吾, 安部 崇重, 佐澤 陽, 原林 透, 篠原 信雄, 鐘ヶ江 香久子, 玉木 長良, 野々村 克也, 日本泌尿器科學會雜誌, 98, 2, 20 Feb. 2007
社団法人日本泌尿器科学会, Japanese - Laparoscopic management of retroperitoneal neurogenic tumors. Approach to suprahilar/hilar tumors
T Harabayashi, K Morita, T Abe, M Miura, A Sazawa, N Shinohara, K Nonomura, JOURNAL OF UROLOGY, 175, 4, 506, 506, Apr. 2006
English, Summary international conference - MP-528 可視化ヒト前立腺癌細胞株を用いた経時観察可能な浸潤転移観察マウスモデルの作成(一般演題ポスター,第94回日本泌尿器科学会総会)
丸山 覚, 佐澤 陽, 安部 崇重, 原林 透, 篠原 信雄, 野々村 克也, 日本泌尿器科學會雜誌, 97, 2, 10 Mar. 2006
社団法人日本泌尿器科学会, Japanese - Salvage chemotherapy with paclitaxel, ifosfamide, and nedaplatin in patients with urothelial cancer who have received prior cisplatin-based therapy
N Shinohara, S Suzuki, T Abe, A Sazawa, T Harabayashi, K Nonomura, JOURNAL OF UROLOGY, 173, 4, 358, 358, Apr. 2005
English, Summary international conference - Cisplatin、Paclitaxel 抵抗性尿路上皮癌に対する Gemcitabin、Docetaxel 併用療法(第93回日本泌尿器科学会総会)
土屋 邦彦, 鈴木 信, 原林 透, 佐澤 陽, 安部 崇重, 三浪 圭太, 丸山 覚, 宮島 直人, 篠原 信雄, 野々村 克也, 日本泌尿器科學會雜誌, 96, 2, 05 Mar. 2005
社団法人日本泌尿器科学会, Japanese - 膀胱癌間質ではEB virus 陽性リンパ球の浸潤を高率に認める(第93回日本泌尿器科学会総会)
安部 崇重, 多田 光宏, 篠原 信雄, 原林 透, 佐澤 陽, 三浪 圭太, 丸山 覚, 野々村 克也, 日本泌尿器科學會雜誌, 96, 2, 05 Mar. 2005
社団法人日本泌尿器科学会, Japanese - SCIDマウスを利用したヒト尿路上皮癌xenograft modelの樹立(Establishment and characteristics of human urotherial cancer xenografts in SCID mice)
安部 崇重, 多田 光宏, 篠原 信雄, 岡田 太, 原林 透, 浜田 淳一, 守内 哲也, 野々村 克也, 日本癌学会総会記事, 63回, 364, 364, Sep. 2004
日本癌学会, English - Impact of cyclooxygenase-2 gene expression on tumor invasiveness in human renal cell carcinoma cell line
QZ Chen, N Shinohara, T Abe, T Harabayashi, K Nonomura, JOURNAL OF UROLOGY, 171, 4, 267, 267, Apr. 2004
English, Summary international conference - OP2-019 経直腸式前立腺生検 : 6箇所生検と12箇所生検の比較検討(一般演題(口演))
杉下 圭治, 篠原 信雄, 三浪 圭太, 古野 剛史, 丸山 覚, 安部 崇重, 谷口 明久, 鈴木 信, 原林 透, 野々村 克也, 日本泌尿器科學會雜誌, 95, 2, 15 Mar. 2004
社団法人日本泌尿器科学会, Japanese - OP3-064 局所浸潤前立腺癌に対する放射線療法と前立腺全摘除術の治療成績に関する検討(一般演題(口演))
鈴木 信, 篠原 信雄, 白土 博樹, 原林 透, 大坂 康信, 安部 崇重, 丸山 覚, 出村 孝義, 小柳 知彦, 野々村 克也, 日本泌尿器科學會雜誌, 95, 2, 15 Mar. 2004
社団法人日本泌尿器科学会, Japanese - PP4-037 SCIDマウスを利用したヒト尿路上皮癌xenograftモデルの樹立(一般演題(ポスター))
安部 崇重, 多田 光宏, 篠原 信雄, 岡田 太, 伊藤 智雄, 原林 透, 浜田 淳一, 鈴木 信, 三浪 圭太, 丸山 覚, 守内 哲也, 野々村 克也, 日本泌尿器科學會雜誌, 95, 2, 15 Mar. 2004
社団法人日本泌尿器科学会, Japanese - 小径腎腫瘍に対するマイクロ波を用いた体腔鏡下腎部分切除術の短期成績と問題点
原林 透, 鈴木 信, 篠原 信雄, 安部 崇重, 三浪 圭太, 土屋 邦彦, 佐澤 陽, 森田 研, 柿崎 秀宏, 野々村 克也, J. Microwave Surg., 22, 133, 136, 2004 - 後腹膜パラガングリオーマに対する腹腔鏡下摘除術の経験
岩見 大基, 原林 透, 柿崎 秀宏, 安部 崇重, 小柳 知彦, 泌尿器外科, 15, 3, 272, 272, Mar. 2002
医学図書出版(株), Japanese
Research Themes
- Motion and image analyses of laparoscopic surgery : visualization of experts' surgical skills, and future surgical education
Grants-in-Aid for Scientific Research
01 Apr. 2024 - 31 Mar. 2027
安部 崇重, 樋口 まどか, 倉島 庸, 今 雅史, 渡辺 雅彦, 七戸 俊明, 近野 敦, 堀田 記世彦
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 24K00443 - Laparoscopic surgical dynamic navigation using maximum likelihood estimation of organ deformations
Grants-in-Aid for Scientific Research
01 Apr. 2023 - 31 Mar. 2026
近野 敦, 安部 崇重, 妹尾 拓, 小水内 俊介, 安孫子 聡子, 辻田 哲平, 陳 暁帥, 佐瀬 一弥
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Hokkaido University, 23H00480 - Development of new diagnostic method of bladder cancer based on mRNA derived from urine exosome
Grants-in-Aid for Scientific Research
01 Apr. 2022 - 31 Mar. 2025
大澤 崇宏, 伊藤 陽一, 安部 崇重, 樋田 京子, 篠原 信雄
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 22K09439 - Motion analysis of laparoscopic surgical skills in experts and its use for surgical education
Grants-in-Aid for Scientific Research
01 Apr. 2021 - 31 Mar. 2024
安部 崇重, 渡辺 雅彦, 七戸 俊明, 篠原 信雄, 近野 敦
鉗子動態に基づく手術技量評価法の開発
これまでのウエットラボ参加者70名の鉗子動態計測データを用いて、手術経験数を熟練度の指標として用い、サポートベクターマシン等を用いて、鉗子動態に基づく手術技量分析能を評価した。良好な弁別能を観察しており、現在論文投稿中である。また、これまでのウェットラボ記録ビデオに関して、腹腔鏡手術技術評価表であるGOALS評価表を使用し、2名の腹腔鏡技術認定医による技術評価を修了した。GOALS評価表は、1. Depth perception, 2. Bimanual dexterity, 3. Efficiency, 4.Tissu handling, 5. Autonomy の5項目を、それぞれ1-5段階で評価を行う形式で、5-25点の点数が割り付けられる。R3年度は、鉗子動態計測値とGOALSスコアの相関評価を行い、鉗子動態に基づく機械学習を用いたGOALSスコアの自動計算法を開発した。現在、論文投稿中である。
カダバーを用いた腹腔鏡下腎摘除術トレーニングプログラムの開発と鉗子動態の計測・解析
使用するカダバーは、シール法と呼ばれる固定方法の献体で、生体と比較し良好な組織類似性が特徴である。2020年9月末より腹腔鏡下腎摘除術トレーニングにおいて、三眼カメラOptiTrack V 120 Trioを用いて鉗子動態計測を開始している。R3年度は、18名の参加者に関して、カダバー腹腔鏡下腎摘除術の鉗子動態の測定を行った。
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 21H00893 - Development of the new system to appropriately assess health related quality of life in patients with bladder cancer survivor using patient reported outcome.
Grants-in-Aid for Scientific Research
01 Apr. 2018 - 31 Mar. 2021
Osawa Takahiro
We validated a Japanese version of the bladder cancer index (BCI) as a tool for measuring health-related quality of life (HRQOL) in bladder cancer patients treated with various surgical procedures. In addition, we characterized health related quality of life (HRQOL) in Japanese patients after bladder cancer surgery and to perform cross-cultural comparison between Japanese and American patients.
Although revisions are needed to make it easier for elderly patients to comprehend, we confirmed the reliability and validity of the Japanese BCI. The Japanese BCI could be used for cross-cultural assessments of HRQOL in bladder cancer patients. HRQOL outcomes following treatment of bladder cancer in Japan are comparable to those in the USA, except for sexual functioning and sexual bother. The BCI can be used for cross-cultural assessments of HRQOL in bladder cancer patients.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 18K09155 - Continuous training system for developing highly competent endoscopic surgeons
Grants-in-Aid for Scientific Research
01 Apr. 2017 - 31 Mar. 2020
Abe Takashige
We develop a wet-lab training model for learning laparoscopic surgical skills and evaluating learners’ competency level outside the operating room, using swine organs. 45 participants (experts [≧50 laparoscopic surgeries]: n=13, intermediates [11-49]: n=8, novices [0-10]: n=33) completed 3 tasks (Task 1: tissue dissection around aorta, Task 2: tissue dissection and divide renal artery, Task 3: renal parenchymal closure). Each performance was video-recorded and later evaluated by two experts, according to Global Operative Assessment of Laparoscopic Skills. We observed good construct validity in all 3 tasks. The subjective mental workload was also assessed (NASA Task Load Index [NASA-TLX]), and higher NASA-TLX scores were observed in novices.
We also evaluated the validity of the laparoscopic radical nephrectomy module of the LapVision virtual reality simulator. 33 subjects performed training, and we observed good construct validities for the nephrectomy module.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 17K08897 - Building the high-reliability surgical team by use of previous medical incidents reports
Grants-in-Aid for Scientific Research
01 Apr. 2014 - 31 Mar. 2017
Abe Takashige
Using the relevant key words with minimum invasive surgeries, 540 records were identified in the database of the Japan Council for Quality Health Care. After data review and the classification of adverse events, 746 events associated with laparoscopic (laparo-group) and/or thoracoscopic (thoraco-group) surgery were identified. There were 582 events in the laparo-group, 159 in the thoraco-group, and 5 in those undergoing a combined surgery. Overall, injury of other organs, retention of a foreign body, breakage/failure of medical equipment or devices, massive bleeding, misperception of anatomy, and vascular injurywere frequently reported. There were marked differences in the frequency of injury of other organs, massive bleeding, and vascular injury.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 26460853 - Novel pathological parameters in regional lymph nodes of urothelial carcinoma focused on "Seed and Soil" theory
Grants-in-Aid for Scientific Research
2010 - 2011
ABE Takashige
Study 1 : Fifty-one patients treated by nephroureterectomy were included. All had lymph nodes(LNs) and all LNs were negative on hematoxylin and eosin staining. We re-evaluated the presence of micrometastasis in LNs specimens by anti-cytokeratin immunohistochemistory. Immunohistochemistry identified micrometastases in 7(14%) of 51 patients. Study 2 : We prospectively evaluated the presence of micrometastasis in LNs in patients undergoing radical cystectomy or nephroureterectomy. Micrometastasis was detected in 9%(2/22) of patients undergoing radical cystectomy. Study 3 : We evaluated the association between the expression of VEGFC mRNA, VEGFD mRNA, or VEGF3R mRNA and pathological characteristic in primary tumors. We subsequently evaluated the lymph vascular density(LVD) in marginal zone of regional lymph nodes. The expression of VEGFC mRNA was higher in> pT2 disease thanJapan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, 22791462
