Oct. 2022, 第42回日本サルコイドーシス／肉芽腫性疾患学会総会, 最優秀演題賞　　　　　　　　　　　　　　　
Young Investigator's Award Case Report部門

2021, 一般財団法人 北海道心臓協会 研究開発調査助成賞　　　　　　　　　　　　　　　

2021, 第17回（令和3年度）北海道大学大学院医学研究院・医学部医学科 音羽博次奨学基金.　　　　　　　　　　　　　　　

Serum Vasoactive Intestinal Peptide as a Novel Biomarker for Low-Voltage Areas in Patients With Atrial Fibrillation.
Kotaro Nishino, Taro Temma, Hiroyuki Natsui, Masaya Watanabe, Motoki Nakao, Masahiro Kawasaki, Kintaro Shimano, Kei Kawakami, Shota Saito, Jiro Koya, Daishiro Tatsuta, Takuya Koizumi, Takahide Kadosaka, Taro Koya, Satonori Tsuneta, Kiwamu Kamiya, Toshiyuki Nagai, Toshihisa Anzai
Journal of the American Heart Association, 14, 7, e039192, Apr. 2025, [International Magazine]
English, Scientific journal, BACKGROUND: Low-voltage areas in the left atrium predict atrial fibrillation recurrence after catheter ablation and are associated with adverse outcomes like death, heart failure, and stroke. Detecting low-voltage areas (LVAs) typically requires invasive procedures, highlighting the need for a simple, minimally invasive marker. Vasoactive intestinal peptide (VIP), a neuropeptide released during parasympathetic stimulation, affects electrophysiological remodeling in atrial fibrillation. We hypothesized that serum VIP could serve as a biomarker for detecting LVAs in these patients. METHODS AND RESULTS: This prospective, cross-sectional study was conducted at Hokkaido University Hospital between August 2021 and September 2023. We included 108 patients with atrial fibrillation scheduled for catheter ablation. Blood samples were collected during ablation to measure VIP using an ELISA. Electroanatomical mapping identified LVAs, defined as regions with bipolar voltage ≤0.5 mV and occupying >5% of the left atrial surface. Statistical analyses evaluated the relationship between VIP and LVAs. Fifty-one patients (47%) had LVAs, with significantly higher serum VIP levels than those without (335.1 versus 247.7 pg/mL, P<0.001). VIP levels and female sex were statistically significant factors of LVAs. Adding VIP to the existing score significantly improved its discrimination (area under the curve: 0.784 versus 0.707, P<0.001). CONCLUSIONS: Serum VIP levels are higher in patients with atrial fibrillation with LVAs, suggesting its potential as a noninvasive biomarker for detecting these areas and improving clinical management.

Normalization of increasing shocking coil impedance with full output synchronized shock.
Takahide Kadosaka, Masaya Watanabe, Motoki Nakao, Taro Koya, Taro Temma, Toshihisa Anzai
Journal of cardiovascular electrophysiology, 21 Aug. 2024, [International Magazine]
English, Scientific journal, INTRODUCTION: Impedance is a crucial parameter in cardiovascular implantable electronic devices (CIEDs). Clinically, most CIEDs measure impedance using low voltage sub-threshold measurement (LVSM). Although the LVSM of shock impedance (LVSM-SI) is generally comparable with high voltage shock impedance (HVSI), LVSM-SI might be inaccurate if peri-lead tissue degeneration occurs. METHODS AND RESULTS: We present a case of elevated LVSM-SI occurring 8 years post-lead implantation, possibly attributed to encapsulation of the right ventricular lead coil. After 0.1 J shock was delivered, a full output synchronized shock was administered to measure HVSI, revealing a normal value. Furthermore, LVSM-SI was normalized and maintained within the normal range during long-term follow-up. CONCLUSION: Our findings suggest conducting a full-output synchronized shock test to assess HVSI when abnormal LVSM-SI is detected in the remote phase post-ICD implantation, which may be considered to help normalize LVSM shock impedance.

Influence of epicardial adipose tissue inflammation and adipocyte size on postoperative atrial fibrillation in patients after cardiovascular surgery
Hiroyuki Natsui, Masaya Watanabe, Takashi Yokota, Satonori Tsuneta, Yoshizuki Fumoto, Haruka Handa, Matsushima Shouji, Jiro Koya, Kotaro Nishino, Daishiro Tatsuta, Takuya Koizumi, Takahide Kadosaka, Motoki Nakao, Taro Koya, Taro Temma, Yoichi M. Ito, Hatanaka C. Kanako, Yutaka Hatanaka, Shingu Yasushige, Satoru Wakasa, Shuhei Miura, Takahiko Masuda, Naritomo Nishioka, Shuichi Naraoka, Kayoko Ochi, Tomoko Kudo, Tsugumine Ishikawa, Toshihisa Anzai
Physiological Reports, 12, 6, Wiley, 28 Mar. 2024
Scientific journal, Abstract

Epicardial adipose tissue (EAT) is an active endocrine organ that is closely associated with occurrence of atrial fibrillation (AF). However, the role of EAT in the development of postoperative AF (POAF) remains unclear. We aimed to investigate the association between EAT profile and POAF occurrence in patients who underwent cardiovascular surgery. We obtained EAT samples from 53 patients to evaluate gene expression, histological changes, mitochondrial oxidative phosphorylation (OXPHOS) capacity in the EAT, and protein secretion in EAT‐conditioned medium. EAT volume was measured using computed tomography scan. Eighteen patients (34%) experienced POAF within 7 days after surgery. Although no significant difference was observed in EAT profile between patients with and without POAF, logistic regression analysis identified that the mRNA expression levels of tumor necrosis factor‐alpha (TNF‐α) were positively correlated and adipocyte size in the EAT was inversely correlated with onset of POAF, respectively. Mitochondrial OXPHOS capacity in the EAT was not associated with POAF occurrence; however, it showed an inverse correlation with adipocyte size and a positive correlation with adiponectin secretion. In conclusion, changes in the secretory profile and adipocyte morphology of the EAT, which represent qualitative aspects of the adipose tissue, were present before the onset of AF.

日本人高齢患者における植え込み型除細動器の有用性(Benefit of Implantable Cardioverter-defibrillator in Elderly Japanese Patients)　　　　　　　　　　　　　　　
甲谷 次郎, 天満 太郎, 立田 大志郎, 西野 広太郎, 夏井 宏征, 門坂 崇秀, 小泉 拓也, 甲谷 太郎, 中尾 元基, 渡邉 昌也, 安斉 俊久
日本循環器学会学術集会抄録集, 87回, PJ113, 4, (一社)日本循環器学会, Mar. 2023
English

Optogenetic termination of atrial tachyarrhythmias by brief pulsed light stimulation
Motoki Nakao, Masaya Watanabe, Lucile Miquerol, Hiroyuki Natsui, Takuya Koizumi, Takahide Kadosaka, Taro Koya, Hikaru Hagiwara, Rui Kamada, Taro Temma, Antoine A.F. de Vries, Toshihisa Anzai
Journal of Molecular and Cellular Cardiology, Elsevier BV, Mar. 2023
Scientific journal

Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats
Takuya Koizumi, Masaya Watanabe, Takashi Yokota, Masumi Tsuda, Haruka Handa, Jiro Koya, Kotaro Nishino, Daishiro Tatsuta, Hiroyuki Natsui, Takahide Kadosaka, Taro Koya, Motoki Nakao, Hikaru Hagiwara, Rui Kamada, Taro Temma, Shinya Tanaka, Toshihisa Anzai
Frontiers in Cardiovascular Medicine, 10, Frontiers Media SA, 06 Feb. 2023
Scientific journal, Introduction

Recent studies have demonstrated that sodium-glucose co-transporter-2 inhibitors (SGLT2-i) reduce the risk of atrial fibrillation (AF) in patients with diabetes mellitus (DM), in which oxidative stress due to increased reactive oxygen species (ROS) contributes to the pathogenesis of AF. We aimed to further investigate this, and examine whether the SGLT2-i empagliflozin suppresses mitochondrial-ROS generation and mitigates fibrosis.

Methods

A high-fat diet and low-dose streptozotocin treatment were used to induce type-2 DM (T2DM) in Sprague-Dawley rats. The rats were randomly divided into three groups: control, DM, and DM treated with empagliflozin (30 mg/kg/day) for 8 weeks. The mitochondrial respiratory capacity and ROS generation in the atrial myocardium were measured using a high-resolution respirometer. Oxidative stress markers and protein expression related to mitochondrial biogenesis and dynamics as well as the mitochondrial morphology were examined in the atrial tissue. Additionally, mitochondrial function was examined in H9c2 cardiomyoblasts. Atrial tachyarrhythmia (ATA) inducibility, interatrial conduction time (IACT), and fibrosis were also measured.

Results

Inducibility of ATA, fibrosis, and IACT were increased in rats with DM when compared to controls, all of which were restored by empagliflozin treatment. In addition, the rats with DM had increased mitochondrial-ROS with an impaired complex I-linked oxidative phosphorylation capacity. Importantly, empagliflozin seemed to ameliorate these impairments in mitochondrial function. Furthermore, empagliflozin reversed the decrease in phosphorylated AMPK expression and altered protein levels related to mitochondrial biogenesis and dynamics, and increased mitochondrial content. Empagliflozin also improved mitochondrial function in H9c2 cells cultured with high glucose medium.

Discussion

These data suggest that empagliflozin has a cardioprotective effect, at least in part, by reducing mitochondrial ROS generation through AMPK signaling pathways in the atrium of diabetic rats. This suggests that empagliflozin might suppress the development of AF in T2DM.

Fragmented QRS on 12-lead electrocardiogram predicts long-term prognosis in patients with cardiac sarcoidosis.
Hikaru Hagiwara, Masaya Watanabe, Takahide Kadosaka, Takuya Koizumi, Yuta Kobayashi, Taro Koya, Motoki Nakao, Satonori Tsuneta, Yoshiya Kato, Hirokazu Komoriyama, Rui Kamada, Toshiyuki Nagai, Kohsuke Kudo, Toshihisa Anzai
Heart and vessels, 13 Jan. 2023, [Domestic magazines]
English, Scientific journal, Fragmented QRS (fQRS) on a 12-lead electrocardiogram is a known marker of fatal arrhythmias or cardiac adverse events in ischemic and non-ischemic cardiomyopathy patients. Nonetheless, the association between fQRS and clinical outcomes in patients with cardiac sarcoidosis (CS) remains unclear. Herein, we investigated whether fQRS is associated with long-term clinical outcomes in CS patients. A total of 78 patients who received immunosuppressive therapy (IST) for clinically diagnosed CS were retrospectively examined. Patients were classified into two groups according to the presence (n = 19) or absence (n = 59) of fQRS on electrocardiogram before IST. The primary outcome was the composite event of all-cause death, ventricular tachyarrhythmias (VTs), and hospitalization for heart failure. Results of late gadolinium enhancement on cardiac magnetic resonance imaging were also analyzed. During a median follow-up period of 3.7 years (interquartile range: 1.6-6.2 years), the primary outcome occurred more frequently in patients with fQRS than in those without (47% vs. 13%, log-rank p = 0.002). Multivariable Cox regression analyses showed that fQRS was an independent determinant of the primary outcome. The incidence of VTs, within 12 months of IST initiation, was comparable between the two groups; however, late-onset VTs, defined as those occurring ≥ 12 months after IST initiation, occurred more frequently in the fQRS group (21% vs. 2%, log-rank p = 0.002). The scar zone and scar border zone were greater in patients with fQRS than in those without it. In conclusion, our analysis suggests that fQRS is an independent predictor of adverse events, particularly late-onset VTs, in patients with CS.

Empagliflozin attenuates arrhythmogenesis in diabetic cardiomyopathy by normalizing intracellular Ca2+ handling in ventricular cardiomyocytes.
Takahide Kadosaka, Masaya Watanabe, Hiroyuki Natsui, Takuya Koizumi, Motoki Nakao, Taro Koya, Hikaru Hagiwara, Rui Kamada, Taro Temma, Fuyuki Karube, Fumino Fujiyama, Toshihisa Anzai
American journal of physiology. Heart and circulatory physiology, 324, 3, H341-H354, 06 Jan. 2023, [International Magazine]
English, Scientific journal, Diabetic cardiomyopathy has been reported to increase the risk of fatal ventricular arrhythmia. The beneficial effects of the selective sodium-glucose co-transporter 2 inhibitor have not been fully examined in the context of anti-arrhythmic therapy, especially its direct cardioprotective effects despite the negligible SGLT2 expression in cardiomyocytes. We aimed to examine the anti-arrhythmic effects of empagliflozin (EMPA) treatment on diabetic cardiomyocytes, with a special focus on Ca2+ handling. We conducted echocardiography and hemodynamic studies and studied electrophysiology, Ca2+ handling, and protein expression in C57BLKS/J-leprdb/db mice (db/db mice) and their non-diabetic lean heterozygous Leprdb/+ littermates (db/+ mice). Preserved systolic function with diastolic dysfunction was observed in 16-week-old db/db mice. During arrhythmia induction, db/db mice had significantly increased premature ventricular complexes (PVCs) than controls, which was attenuated by EMPA. In protein expression analyses, calmodulin-dependent protein kinase II (CaMKII) Thr287 autophosphorylation and CaMKII-dependent RyR2 phosphorylation (S2814) were significantly increased in diabetic hearts, which were inhibited by EMPA. Additionally, global O-GlcNAcylation significantly decreased with EMPA treatment. Furthermore, EMPA significantly inhibited ventricular cardiomyocyte glucose uptake. Diabetic cardiomyocytes exhibited increased spontaneous Ca2+ events and decreased sarcoplasmic reticulum (SR) Ca2+ content, along with impaired Ca2+ transient, all of which normalized with EMPA treatment. Notably, most EMPA-induced improvements in Ca2+ handling were abolished by the addition of an O-GlcNAcase (OGA) inhibitor. In conclusion, EMPA attenuated ventricular arrhythmia inducibility by normalizing the intracellular Ca2+ handling, and we speculated that this effect was, at least partly, due to the inhibition of O-GlcNAcylation via the suppression of glucose uptake into cardiomyocytes.

Pharmacological nNOS inhibition modified small-conductance Ca2+-activated K+ channel without altering Ca2+ dynamics.
Taro Koya, Masaya Watanabe, Hiroyuki Natsui, Takahide Kadosaka, Takuya Koizumi, Motoki Nakao, Hikaru Hagiwara, Rui Kamada, Taro Temma, Toshihisa Anzai
American journal of physiology. Heart and circulatory physiology, 323, 5, H869-H878, 01 Nov. 2022, [International Magazine]
English, Scientific journal, Atrial fibrillation (AF) is associated with electrical remodeling processes that promote a substrate for the maintenance of AF. Although the small-conductance Ca2+-activated K+ (SK) channel is a key factor in atrial electrical remodeling, the mechanism of its activation remains unclear. Regional nitric oxide (NO) production by neuronal nitric oxide synthase (nNOS) is involved in atrial electrical remodeling. In this study, atrial tachyarrhythmia (ATA) induction and optical mapping were performed on perfused rat hearts. nNOS is pharmacologically inhibited by S-methylthiocitrulline (SMTC). The influence of the SK channel was examined using a specific channel inhibitor, apamin (APA). Parameters such as action potential duration (APD), conduction velocity, and calcium transient (CaT) were evaluated using voltage and calcium optical mapping. The dominant frequency was examined in the analysis of AF dynamics. SMTC (100 nM) increased the inducibility of ATA and apamin (100 nM) mitigated nNOS inhibition-induced arrhythmogenicity. SMTC caused abbreviations and enhanced the spatial dispersion of APD, which was reversed by apamin. By contrast, conduction velocity and other parameters associated with CaT were not affected by SMTC or apamin administration. Apamin reduced the frequency of SMTC-induced ATA. In summary, nNOS inhibition abbreviates APD by modifying the SK channels. A specific SK channel blocker, apamin, mitigated APD abbreviation without alteration of CaT, implying an underlying mechanism of posttranslational modification of SK channels.NEW & NOTEWORTHY We demonstrated that pharmacological nNOS inhibition increased the atrial arrhythmia inducibility and a specific small-conductance Ca2+-activated K+ channel blocker, apamin, reversed the enhanced atrial arrhythmia inducibility. Apamin mitigated APD abbreviation without alteration of Ca2+ transient, implying an underlying mechanism of posttranslational modification of SK channels.

Stimulation of the mitochondrial calcium uniporter mitigates chronic heart failure-associated ventricular arrhythmia in mice.
Hikaru Hagiwara, Masaya Watanabe, Yoichiro Fujioka, Takahide Kadosaka, Takuya Koizumi, Taro Koya, Motoki Nakao, Rui Kamada, Taro Temma, Kazufumi Okada, Jose Antonio Moreno, Ohyun Kwon, Hisakata Sabe, Yusuke Ohba, Toshihisa Anzai
Heart rhythm, 19, 10, 1725, 1735, 31 May 2022, [International Magazine]
English, Scientific journal, BACKGROUND: An aberrant increase in the diastolic calcium concentration ([Ca2+]i) level is a hallmark of heart failure (HF) and the cause of delayed afterdepolarization and ventricular arrhythmia (VA). Although mitochondria play a role in regulating [Ca2+]i, whether they can compensate for the [Ca2+]i abnormality in ventricular myocytes is unknown. OBJECTIVE: We investigated whether enhanced Ca2+ uptake of mitochondria may compensate for an abnormal increase in the [Ca2+]i of ventricular myocytes in HF to effectively mitigate VA. METHODS: We used a HF mouse model, in which myocardial infarction was induced by permanent left anterior descending coronary artery ligation. The mitochondrial Ca2+ uniporter was stimulated by kaempferol. Ca2+ dynamics and membrane potential were measured using an epifluorescence microscope, a confocal microscope, and the perforated patch-clamp technique. VA was induced in the Langendorff-perfused hearts, and the hemodynamic parameters were measured using a microtip transducer catheter. RESULTS: Protein expression of the mitochondrial Ca2+ uniporter, as assessed by its subunit expression, did not change between HF and sham mice. Treatment of cardiomyocytes with kaempferol, isolated from HF mice at 28 days after coronary ligation, reduced the appearance of aberrant diastolic [Ca2+]i waves and sparks and spontaneous action potentials. Kaempferol effectively reduced the VA occurring in Langendorff-perfused hearts. Intravenous administration of kaempferol did not markedly affect the left ventricular hemodynamic parameters. CONCLUSION: The effects of kaempferol in HF of mice implied that mitochondria may have the potential to compensate for abnormal [Ca2+]i. Mechanisms involved in mitochondrial Ca2+ uptake may provide novel targets to treat HF-associated VA.

Predictors of cardiovascular mortality after an electrical storm in patients with structural heart disease.
Takuya Koizumi, Rui Kamada, Masaya Watanabe, Hisashi Yokoshiki, Taro Temma, Hikaru Hagiwara, Taro Koya, Motoki Nakao, Takahide Kadosaka, Hiroyuki Natsui, Masayuki Takahashi, Kazuya Mizukami, Hirofumi Mitsuyama, Toshihisa Anzai
Journal of cardiology, 80, 2, 167, 171, 29 Mar. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: Electrical storms (ESs) in patients with structural heart disease (SHD) have been reported to be associated with a poor prognosis. However, the detailed cause of death and influence of implantable cardioverter defibrillator (ICD) therapy in ES patients have not been fully investigated. Therefore, we sought to explore the detailed clinical course after an ES and the impact of the ICD therapy in patients with SHDs. METHODS: We retrospectively analyzed 31 consecutive patients with ESs who had undergone an ICD implantation. ESs were defined as three or more ventricular arrhythmias within 24 h. RESULTS: During a mean follow up of 4.5 years, 13 patients died. Among them, cardiovascular death (CVD) was observed in 11/13 (85%), and the leading cause of the CVD was end-stage heart failure. A New York Heart Association class ≥III at the time of the ES occurrence (HR 6.51 95% CI 1.94-25.1, p = 0.003) and any shock therapy (HR 5.94 95% CI 1.06-112.2, p = 0.04) were associated with CVD. CONCLUSION: In the current single center study, the major cause of death in ES patients with SHDs was end-stage heart failure. Any shock therapy was associated with CVD. Arrhythmia management to avoid ICD shocks might reduce the mortality in ES patients.

Suppression of Mitochondrial Oxidative Stress and Atrial Fibrillation Inducibility by SGLT2 Inhibitors in Diabetic Rats(和訳中)　　　　　　　　　　　　　　　
小泉 拓也, 渡邉 昌也, 横田 卓, 夏井 宏征, 門坂 崇秀, 甲谷 太郎, 中尾 元基, 萩原 光, 鎌田 塁, 天満 太郎, 安斉 俊久
日本循環器学会学術集会抄録集, 86回, MPJ14, 4, (一社)日本循環器学会, Mar. 2022
English

Hybrid epicardial ventricular tachycardia ablation with lateral thoracotomy in a patient with a history of left ventricular reconstruction surgery.
Taro Koya, Masaya Watanabe, Rui Kamada, Hikaru Hagiwara, Motoki Nakao, Takahide Kadosaka, Takuya Koizumi, Toshihisa Anzai
Journal of cardiology cases, 25, 1, 37, 41, Jan. 2022, [Domestic magazines]
English, Although a hybrid procedure involving surgical access may be feasible for epicardial catheter ablation in individuals with prior cardiac surgery, surgical approaches in thoracotomy are important in patients with advanced adhesions. We performed an epicardial ventricular tachycardia (VT) ablation in a patient with dilated phase hypertrophic cardiomyopathy after left ventricular reconstruction. We gained surgical epicardial access via lateral thoracotomy based on the anticipated VT circuit in the apical anteroseptal area, which was estimated using prior endocardial mapping. The remaining epicardial myocardium around the surgical incision was involved in the central isthmus, and the VT was eliminated by radiofrequency catheter ablation. .

Takotsubo Syndrome After Transcatheter Mitral Valve Repair.
Takahide Kadosaka, Kiwamu Kamiya, Toshiyuki Nagai, Toshihisa Anzai
Circulation journal : official journal of the Japanese Circulation Society, 85, 7, 1100, 1100, 25 Jun. 2021, [Domestic magazines]
English, Scientific journal

Association of Low Body Weight with Clinical Outcomes in Elderly Atrial Fibrillation Patients Receiving Apixaban-J-ELD AF Registry Subanalysis.
Takahide Kadosaka, Toshiyuki Nagai, Shinya Suzuki, Ichiro Sakuma, Masaharu Akao, Takeshi Yamashita, Toshihisa Anzai, Ken Okumura
Cardiovascular drugs and therapy, 36, 4, 691, 703, 08 Apr. 2021, [International Magazine]
English, Scientific journal, PURPOSE: Although direct oral anticoagulants are effective and safe in preventing stroke in atrial fibrillation (AF) patients with low body weight, data remain limited in AF patients with extremely low body weight (<50 kg). We aimed to investigate the association of this body weight category with clinical outcomes in elderly AF patients receiving apixaban. METHODS: The J-ELD AF Registry is a large-scale, multicenter prospective observational study of Japanese non-valvular AF patients aged ≥ 75 years taking on-label doses of apixaban. The entire cohort (3025 patients from 110 institutions) was divided into three body weight subgroups: >60 kg (n = 1019, 33.7%), 50-60 kg (n = 1126, 37.2%), and <50 kg (n = 880, 29.1%). RESULTS: The event incidence rates (/100 person years) were 1.69, 1.82, and 1.23 for stroke or systemic embolism (P = 0.60); 1.37, 1.73, and 2.73 for bleeding requiring hospitalization (P = 0.154); 2.02, 2.67, and 4.92 for total death (P = 0.003); and 0.73, 0.95, and 1.23 for cardiovascular death (P = 0.57), respectively. After adjusting for confounders by Cox regression analysis, body weight <50 kg was not an independent risk for stroke or systemic embolism, bleeding requiring hospitalization, total death, or cardiovascular death. CONCLUSIONS: The incidence of events in each body weight group was comparable for stroke or systemic embolism and bleeding requiring hospitalization, and body weight <50 kg might not be an independent risk for death in Japanese non-valvular AF patients aged ≥ 75 years taking on-label doses of apixaban.

Acute Myocardial Infarction of the Left Main Coronary Artery Presenting with Cardiogenic Shock and Pulmonary Edema during Noncardiac Surgery.
Sakae Takenaka, Takao Konishi, Tomoya Sato, Atsushi Tada, Takuya Koizumi, Yoshifumi Mizuguchi, Takahide Kadosaka, Ko Motoi, Yuta Kobayashi, Hirokazu Komoriyama, Yoshiya Kato, Miwa Sarashina, Kazunori Omote, Shingo Tsujinaga, Takuma Sato, Rui Kamada, Kiwamu Kamiya, Hiroyuki Iwano, Toshiyuki Nagai, Tatsuya Orimo, Hirofumi Kamachi, Akinobu Taketomi, Toshihisa Anzai
Case reports in cardiology, 2021, 5460816, 5460816, 2021, [International Magazine]
English, Acute myocardial infarction (AMI) caused by severe stenosis of left main coronary artery (LMCA) presenting with cardiogenic shock and pulmonary edema during noncardiac surgery is uncommon, but a catastrophic event. A 77-year-old male with cholangiocarcinoma underwent hepatectomy. During the surgery, he presented with cardiogenic shock, which did not respond to infusion administration or vasopressor. A transesophageal echocardiogram revealed anterior, septal, and lateral severe hypokinesia and impaired left ventricular function. Emergent coronary angiogram showed severe stenosis of LMCA. The patient underwent primary percutaneous coronary intervention (PCI) under the support of intra-aortic balloon pump, followed by extracorporeal membrane oxygenation. The chest roentgenogram showed pulmonary edema. Two days after PCI, he successfully underwent hepatectomy and bile duct resection. Early identification of the cause of hemodynamic instability during noncardiac surgery and invasive strategy are important for minimizing the myocardial injury and improving clinical outcomes in AMI of LMCA.

Cardiac involvement with anti-mitochondrial antibody-positive myositis mimicking cardiac sarcoidosis.
Takahide Kadosaka, Shingo Tsujinaga, Hiroyuki Iwano, Kiwamu Kamiya, Azusa Nagai, Yoshifumi Mizuguchi, Ko Motoi, Kazunori Omote, Toshiyuki Nagai, Ichiro Yabe, Toshihisa Anzai
ESC heart failure, 11 Sep. 2020, [International Magazine]
English, Anti-mitochondrial antibody (AMA)-positive myositis is an atypical inflammatory myopathy characterized by chronic progressive respiratory muscle weakness, muscular atrophy, and cardiac involvement. Arrhythmias, cardiomyopathy, and myocarditis have been reported as cardiac manifestations. Herein, we present the first report of a patient diagnosed with having AMA-positive myositis with cardiac involvement mimicking cardiac sarcoidosis.

Reversible Cancer Therapeutics-related Cardiac Dysfunction Complicating Intra-cardiac Thrombi.
Shingo Tsujinaga, Hiroyuki Iwano, Tomohiro Oshino, Takahide Kadosaka, Yoshifumi Mizuguchi, Ko Motoi, Yasuyuki Chiba, Taro Koya, Taro Temma, Kiwamu Kamiya, Arata Fukushima, Takuya Koizumi, Tomoya Sato, Sakae Takenaka, Atsushi Tada, Suguru Ishizaka, Miwa Sarashina, Kazunori Omote, Rui Kamada, Takao Konishi, Takuma Sato, Toshiyuki Nagai, Hiroko Yamashita, Toshihisa Anzai
Internal medicine (Tokyo, Japan), 59, 17, 2155, 2160, 01 Sep. 2020, [Domestic magazines]
English, Scientific journal, Epirubicin-based chemotherapy carries a risk of inducing heart failure, although the frequency is rare. Bevacizumab, an anti-vascular endothelial growth factor monoclonal antibody, has recently been widely used in patients with recurrent breast cancer as a first-line chemotherapeutic agent. Heart failure or arterial thromboembolism has been reported as a rare cardiovascular complication of bevacizumab. We herein report a breast cancer patient with reversible cancer therapeutics-related cardiac dysfunction associated with bevacizumab and epirubicin complicating intracardiac thrombi in the left atrium and left ventricle. This case underscores the importance of tailored medical planning according to the individual status in patients receiving anti-cancer therapies.

Invasive Cardiac Lipoma Complicating Visceral Inversion.
Takahide Kadosaka, Shingo Tsujinaga, Hiroyuki Iwano, Noriko Oyama-Manabe, Toshihisa Anzai
JACC. Case reports, 2, 10, 1570, 1571, Aug. 2020, [International Magazine]
English, Scientific journal, We report a case of cardiac lipoma with intramyocardial invasion complicated by visceral inversion, which, to the best of our knowledge, has not been reported before. Multimodality imaging played an important role in differential diagnosis and determination of the management strategy. (Level of Difficulty: Advanced.).

Successful epicardial ablation for ventricular tachycardia originating from the true apex of apical aneurysm associated with hypertrophic cardiomyopathy
Motoki Nakao, Masaya Watanabe, Rui Kamada, Hikaru Hagiwara, Yumi Takahashi, Taro Koya, Takahide Kadosaka, Takuya Koizumi, Masanori Hirose, Toshihisa Anzai
Journal of Electrocardiology, 61, 170, 174, Jul. 2020
English, Scientific journal

Emery-Dreifuss muscular dystrophy as a possible cause of coronary embolism.
Atsushi Tada, Takao Konishi, Takuma Sato, Tomoya Sato, Takuya Koizumi, Sakae Takenaka, Yoshifumi Mizuguchi, Takahide Kadosaka, Ko Motoi, Yuta Kobayashi, Hirokazu Komoriyama, Yoshiya Kato, Kazunori Omote, Shingo Tsujinaga, Rui Kamada, Kiwamu Kamiya, Hiroyuki Iwano, Toshiyuki Nagai, Nanase Okazaki, Yoshihiro Matsuno, Toshihisa Anzai
Cardiology journal, 27, 4, 443, 444, 2020, [International Magazine]
English, Scientific journal

Sudden failure of ventricular pacing and recovery in a patient with cardiac sarcoidosis.
Yosuke Terui, Akihiro Nakamura, Hideaki Endo, Takahide Kadosaka, Takashi Nakata, Tasuku Watanabe, Kenjiro Sato, Masanori Kanazawa, Masateru Kondo, Tohru Takahashi, Eiji Nozaki
Journal of arrhythmia, 33, 5, 521, 522, Oct. 2017, [Domestic magazines]
English, Scientific journal, A 76-year-old woman with sarcoidosis who had an implantable pacemaker for complete atrioventricular block was admitted with syncope. Electrocardiogram revealed ventricular pacing failure, and a marked rise in the ventricular pacing threshold. 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) indicated increased uptake of FDG in the ventricular septum. Three days after steroid therapy, the ventricular pacing threshold reverted to normal, and FDG-PET showed decreased FDG uptake in the ventricular septum. In this case report, we demonstrate that a sudden deterioration in the ventricular pacing threshold due to worsening cardiac sarcoidosis can be reversed with early steroid therapy.

Comparison of the measured pre-ejection periods and left ventricular ejection times between echocardiography and impedance cardiography for optimizing cardiac resynchronization therapy.
Kazuki Noda, Hideaki Endo, Takahide Kadosaka, Takashi Nakata, Tasuku Watanabe, Yosuke Terui, Shoko Kajitani, Yuto Monnma, Kenjiro Sato, Masanori Kanazawa, Sota Nakajima, Masateru Kondo, Tohru Takahashi, Akihiro Nakamura, Eiji Nozaki
Journal of arrhythmia, 33, 2, 130, 133, Apr. 2017, [Domestic magazines]
English, Scientific journal, BACKGROUND: The pre-ejection period (PEP) and left ventricular ejection time (LVET) are easily measured by impedance cardiography (ICG). We hypothesized that the PEP/LVET measured by ICG would correlate with that measured by echocardiography, and that PEP/LVET measured by ICG would be useful for cardiac resynchronization therapy (CRT) optimization. METHODS: Newly CRT implanted patients were optimized by echocardiography. The PEP/LVET was measured by echocardiography and ICG in two different settings: optimized setting and right ventricle (RV)-only pacing. RESULTS: The PEP/LVET was significantly decreased in the optimized setting compared with that in RV-only pacing (0.62±0.13 vs 0.75±0.16, p<0.05). The PEP/LVET values calculated by ICG and echocardiography were positively correlated (r=0.553, p=0.003). CONCLUSION: ICG was useful for the optimization of CRT.

2機種のmapping systemにおけるDEEP mappingの検討
平子竜大, 天満太郎, 佐々木亮, 前野幹, 千葉裕基, 伊藤仁弥, 中尾元基, 門坂崇秀, 立田大志郎, 西野広太郎, 甲谷次郎, 齋藤翔太, 川崎祐寛, 島野金太郎, 川上慧, 太田稔, 安斉俊久, 日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2024, 2024

A case of ventricular tachycardia after myocardial infarction in which two bystanders were considered to be connected to a common pathway
中尾元基, 渡邉昌也, 門坂崇秀, 小泉拓也, 夏井宏征, 甲谷次郎, 西野広太郎, 立田大志朗, 天満太郎, 安斉俊久, 横式尚司, 南部忠詞, 四倉昭彦, 吉田泉, 櫻井正之, 臨床心臓電気生理, 47, 2024

除細動閾値テストの必要性を考えさせられた皮下植込み型除細動器の1例
佐々木亮, 天満太郎, 平子竜大, 千葉裕基, 前野幹, 齋藤翔太, 立田大志郎, 甲谷次郎, 西野広太郎, 夏井宏征, 門坂崇秀, 中尾元基, 太田稔, 安斉俊久, 植込みデバイス関連冬季大会プログラム・抄録集(Web), 16th, 2024

リードレスペースメーカ植込みを実施した左心補助人工心臓植込み患者において心室頻拍の遠隔管理に難渋した1例
中尾元基, 天満太郎, 平子竜大, 千葉裕基, 前野幹, 佐々木亮, 齋藤翔太, 甲谷次郎, 西野広太郎, 立田大志郎, 夏井宏征, 門坂崇秀, 渡邉昌也, 安斉俊久, 植込みデバイス関連冬季大会プログラム・抄録集(Web), 16th, 2024

心房細動を合併する非虚血性心疾患患者における植込み型除細動器適切作動の検討
西野広太郎, 天満太郎, 平子竜大, 千葉裕基, 前野幹, 佐々木亮, 齋藤翔太, 甲谷次郎, 立田大志郎, 夏井宏征, 門坂崇秀, 中尾元基, 渡邉昌也, 安斉俊久, 植込みデバイス関連冬季大会プログラム・抄録集(Web), 16th, 2024

植込み型左室補助装置による電磁干渉を回避しえた皮下植込み型除細動器の症例
門坂崇秀, 天満太郎, 渡邉昌也, 平子竜大, 千葉裕基, 前野幹, 佐々木亮, 齋藤翔太, 西野広太郎, 甲谷次郎, 立田大志郎, 夏井宏征, 中尾元基, 安斉俊久, 植込みデバイス関連冬季大会プログラム・抄録集(Web), 16th, 2024

植込み型除細動器の頻拍検出設定においてエキスパートコンセンサスの盲信により適切な頻拍検出がなされなかった1例
立田大志郎, 天満太郎, 平子竜大, 千葉裕基, 前野幹, 佐々木亮, 齋藤翔太, 甲谷次郎, 西野広太郎, 夏井宏征, 門坂崇秀, 中尾元基, 渡邉昌也, 安斉俊久, 植込みデバイス関連冬季大会プログラム・抄録集(Web), 16th, 2024

導線露出を伴うRiata ICDリードに対して,経静脈および外科的アプローチによるハイブリッド治療が有効であったデバイス感染の1例
夏井宏征, 天満太郎, 渡邉昌也, 平子竜大, 千葉裕基, 前野幹, 佐々木亮, 齋藤翔太, 甲谷次郎, 立田大志郎, 西野広太郎, 門坂崇秀, 中尾元基, 南田大朗, 安斉俊久, 植込みデバイス関連冬季大会プログラム・抄録集(Web), 16th, 2024

高齢者における心臓突然死予防目的の植込み型心臓デバイスの有効性
天満太郎, 齋藤翔太, 甲谷次郎, 西野広太郎, 立田大志郎, 夏井宏征, 門坂崇秀, 中尾元基, 平子竜大, 千葉裕基, 前野幹, 佐々木亮, 渡邉昌也, 渡邉昌也, 安斉俊久, 植込みデバイス関連冬季大会プログラム・抄録集(Web), 16th, 2024

日本人における2019HRS/EHRA/APHRS/LAHRS Expert Consensusに基づいた植込み型除細動器治療設定の有効性
甲谷次郎, 天満太郎, 平子竜大, 千葉裕基, 前野幹, 佐々木亮, 齋藤翔太, 立田大志郎, 西野広太郎, 夏井宏征, 門坂崇秀, 中尾元基, 渡邉昌也, 安斉俊久, 植込みデバイス関連冬季大会プログラム・抄録集(Web), 16th, 2024

体重増加とともにlead位置が大きく変動し,不適切作動に至った皮下植込み型除細動器の1例
齋藤翔太, 天満太郎, 西野広太郎, 甲谷次郎, 立田大志郎, 夏井宏征, 門坂崇秀, 平子竜大, 中尾元基, 千葉裕基, 前野幹, 佐々木亮, 安斉俊久, 植込みデバイス関連冬季大会プログラム・抄録集(Web), 16th, 2024

高出力ペーシングによるQRS波形変化がヒス束伝導路の推定に有効であった前中隔副伝導路を有するWPW症候群の1例
立田大志郎, 天満太郎, 齋藤翔太, 甲谷次郎, 西野広太郎, 夏井宏征, 門坂崇秀, 中尾元基, 小野太祐, 渡邉昌也, 安斉俊久, 日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2023, 2023

Epicardial connectionが疑われ大動脈無冠尖から有効通電が得られたPeri-mitral atrial flutterの1例
門坂崇秀, 天満太郎, 平子竜大, 千葉裕基, 前野幹, 佐々木亮, 斎藤翔太, 西野広太郎, 甲谷次郎, 立田大志郎, 夏井宏征, 中尾元基, 渡邉昌也, 安斉俊久, 日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2023, 2023

Intrinsic anti-tachycardia pacingにより植込み型除細動器のショック治療を回避することができた1例
萩原光, 渡邉昌也, 平子竜大, 千葉裕基, 前野幹, 佐々木亮, 甲谷次郎, 立田大志郎, 西野広太郎, 夏井宏征, 門坂崇秀, 小泉拓也, 中尾元基, 甲谷太郎, 小西崇夫, 佐藤琢真, 鎌田塁, 安斉俊久, 植込みデバイス関連冬季大会プログラム・抄録集(Web), 14th, 2022

難治性VTを合併した重症心不全患者に対し,LVAD装着時に心外膜側アブレーションを施行した1例
西野広太郎, 渡邉昌也, 青柳裕之, 甲谷次郎, 立田大志郎, 夏井宏征, 門坂崇秀, 小泉拓也, 甲谷太郎, 中尾元基, 天満太郎, 安斉俊久, 日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2022, 2022

僧帽弁輪旋回型心房頻拍に対しEarly meets late lower threshold機能が有用であった1例
平子竜大, 佐々木亮, 前野幹, 千葉裕基, 伊藤仁弥, 太田稔, 天満太郎, 萩原光, 甲谷太郎, 中尾元基, 小泉拓也, 門坂崇秀, 夏井宏征, 西野広太郎, 立田大志郎, 甲谷次郎, 渡邉昌也, 日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2022, 2022

器質的心疾患患者における繰り返す心室頻拍後の心臓死規定因子の検討
小泉拓也, 鎌田塁, 夏井宏征, 門坂崇秀, 中尾元基, 甲谷太郎, 萩原光, 渡邉昌也, 横式尚司, 安斉俊久, 日本心臓病学会学術集会(Web), 69th, O, 232, Sep. 2021
(一社)日本心臓病学会, Japanese

A novel approach for identification of P1 potential in idiopathic left ventricular tachycardia - estimation on characteristics of the circuit-　　　　　　　　　　　　　　　
Takahide Kadosaka
16th Asia Pacific Heart Rhythm Society Scientific Session, Sep. 2023, Oral presentation

Different effects of defibrillator shocks on a myocardial biomarker between subcutaneous and transvenous implantable cardioverter-defibrillators.　　　　　　　　　　　　　　　
Takahide Kadosaka
Japan Heart Rhythm Society Congress 2023, Jul. 2023, Oral presentation

Empagliflozin attenuate Arrhythmogenesis via inhibition of O-GlcNAcylation in diastolic dysfunction phase of diabetic cardiomyopathy.　　　　　　　　　　　　　　　
Takahide Kadosaka
European Society of Cardiology congress 2022, Aug. 2022, Oral presentation

Difference in the Prognostic Impact of Atrial Fibrillation between Younger and Elder Patients with Implantable Cardioverter-Defibrillator.　　　　　　　　　　　　　　　
門坂崇秀
第86 回日本循環器学会学術集会・APSC2022 – Asian Pacific Society of Cardiology Congress 2022, 13 Mar. 2022