Spatial accessibility of home visiting nursing: An exploratory ecological study.
Kazuki Ohashi, Miho Sato, Kensuke Fujiwara, Takumi Tanikawa, Yasuhiro Morii, Katsuhiko Ogasawara
Health science reports, 7, 9, e70078, 2024年09月, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND AND AIMS: Japan is one of the oldest societies worldwide and manages a system of care for older adults in the community. In the 2000s, a community-based integrated care system was introduced to enable older adults to live in their neighborhoods. Home visiting nursing (HVN) is a crucial component of this system; however, the current and future shortage of home visiting nurses is a concern. Thus, HVN services may not be available in some areas; however, no indicators of the accessibility of HVN services have been developed. Developing accessibility indicators will serve as a standard for considering the allocation of health care resources and supporting future nursing policies that improve regional disparities. METHODS: We estimated the population-weighted spatial accessibility index (PWSAI) of HVN services in Hokkaido, using the two-step floating catchment area method (2SFCA). The 2SFCA comprised population, location of HVN agencies, number of home visiting nurses, and travel time. A multivariate regression model was run for the number of HVN users in each municipality as the objective variable to test the validity of the PWSAI; the number of home care support clinics, home care support hospitals, HVN agencies, home visiting nurses, home visiting nurses (24/7), total beds in health care facilities for older adults, and nursing homes for older adults were included as other explanatory variables. RESULTS: The PWSAI was median 9.0 [interquartile range: 6.2-11.8]. The distribution of the PWSAI was mapped to visualize the existence of regional differences. As a result of the conditional autoregressive model, PWSAI and home visiting nurses (24/7) were significant, Exp(β) and 95% credible interval were 1.043 [1.015-1.076] and 1.021 [1.006-1.036], respectively. CONCLUSION: The PWSAI was positively correlated with the number of HVN users in each municipality and can serve as an indicator for assessing the accessibility of HVN.

Are There Shortages and Regional Disparities in Lecanemab Treatment Facilities? A Cross-Sectional Study
Kazuki Ohashi, Ikuko Takahashi-Iwata, Zhao Jieyu, Ken Sakushima, Ichiro Yabe, Katsuhiko Ogasawara
Health Services Insights, 2024年01月
研究論文（学術雑誌）

The Capacitated Maximal Covering Location Problem Improves Access to Stroke Treatment: A Cross-Sectional Simulation Study.
Kyohei Bando, Kazuki Ohashi, Kensuke Fujiwara, Toshiya Osanai, Yasuhiro Morii, Takumi Tanikawa, Miki Fujimura, Katsuhiko Ogasawara
Health services insights, 17, 11786329241263699, 11786329241263699, 2024年, ［国際誌］
英語, 研究論文（学術雑誌）, Disparities in accessing advanced stroke treatment have been recognized as a policy challenge in multiple countries, including Japan, necessitating priority solutions. Nevertheless, more practical healthcare policies must be implemented due to the limited availability of healthcare staff and financial resources in most nations. This study aimed to evaluate the supply and demand balance of mechanical thrombectomy (MT) and identify areas with high priority for enhancing stroke centers. The target area of this study was Hokkaido, Japan. We adopted the capacitated maximal covering location problem (CMCLP) to propose an optimal allocation without increasing the number of medical facilities. Four realistic scenarios with varying levels of total MT supply capacity for Primary stroke centers and assuming a range of 90 minutes by car from the center were created and simulated. From scenarios 1 to 4, the coverage increased by approximately 53% to 85%, scenarios 2 and 3 had 5% oversupply, and scenario 4 had an oversupply of approximately 20%. When the supply capacity cap was eliminated and 8 PSCs received 31 or more patients, they became priority enhancement targets. The CMCLP estimates demand coverage considering the supply and demand balance and indicates areas and facilities where MT supply capacity enhancement is a priority.

Serum zinc concentration as a potential predictor of presarcopenia in patients with chronic liver disease: a preliminary study.
Mitsuyuki Suzuki, Toru Ishikawa, Kazuki Ohashi, Asami Hoshii, Hiroshi Hirosawa, Hirohito Noguchi, Terasu Honma
Translational gastroenterology and hepatology, 9, 20, 20, 2024年, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Presarcopenia is a common complication of chronic liver disease. However, the relationship between serum zinc concentration and presarcopenia in patients with chronic liver disease remains unclear. Herein, we examined whether serum zinc concentration could predict presarcopenia in patients with chronic liver disease. METHODS: Between October 2015 and December 2019, 278 patients with chronic liver disease (median age, 68 years; women/men, 133/145; hepatitis B virus/hepatitis C virus/negative hepatitis B surface antigen and negative anti-hepatitis C virus antibody, 55/124/99) who underwent abdominal computed tomography (CT) and simultaneous measurement of serum zinc concentration were included. Zinc deficiency and subclinical zinc deficiency were classified using serum zinc concentration cutoff values of <60 and <80 μg/dL [based on the Japanese Society of Clinical Nutrition (JSCN) guidelines], respectively. Additionally, presarcopenia was evaluated based on the skeletal muscle mass as per the Japan Society of Hepatology (JSH)'s sarcopenia criteria. RESULTS: Univariate analysis revealed that the following factors were significantly associated with the presence of presarcopenia in patients with chronic liver disease: age (P<0.001), male sex (P<0.001), body mass index (BMI) (P<0.001), serum zinc concentration (P=0.005), fibrosis-4 index (P<0.001), and serum albumin concentration (P=0.03). Additionally, the median L3 skeletal muscle indices were as follows: men, non-presarcopenia group/presarcopenia group, 47.56/37.91 cm2/m2 (P<0.001); women, non-presarcopenia group/presarcopenia group, 41.64/32.88 cm2/m2 (P<0.001). Multivariate analysis using logistic regression analysis revealed that male sex [odds ratio (OR), 0.194; 95% confidence interval (CI): 0.089-0.419; P<0.001], BMI (OR, 0.666; 95% CI: 0.582-0.761; P<0.001), and serum zinc concentration <60 μg/dL (OR, 5.930; 95% CI: 1.480-23.80; P=0.01) were factors associated with presarcopenia. The OR for serum zinc concentration between 60 and 80 μg/dL was 1.910 (95% CI: 0.824-4.420; P=0.13). CONCLUSIONS: Low serum zinc levels may be an independent predictor of presarcopenia in patients with chronic liver disease.

Optimal allocation of physicians improves accessibility and workload disparities in stroke care.
Kazuki Ohashi, Toshiya Osanai, Kyohei Bando, Kensuke Fujiwara, Takumi Tanikawa, Yuji Tani, Soichiro Takamiya, Hirotaka Sato, Yasuhiro Morii, Tomoki Ishikawa, Katsuhiko Ogasawara
International journal for equity in health, 22, 1, 233, 233, 2023年11月07日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Inequalities in access to stroke care and the workload of physicians have been a challenge in recent times. This may be resolved by allocating physicians suitable for the expected demand. Therefore, this study analyzes whether reallocation using an optimization model reduces disparities in spatial access to healthcare and excessive workload. METHODS: This study targeted neuroendovascular specialists and primary stroke centers in Japan and employed an optimization model for reallocating neuroendovascular specialists to reduce the disparity in spatial accessibility to stroke treatment and workload for neuroendovascular specialists in Japan. A two-step floating catchment area method and an inverted two-step floating catchment area method were used to estimate the spatial accessibility and workload of neuroendovascular specialists as a potential crowdedness index. Quadratic programming has been proposed for the reallocation of neuroendovascular specialists. RESULTS: The reallocation of neuroendovascular specialists reduced the disparity in spatial accessibility and the potential crowdedness index. The standard deviation (SD) of the demand-weighted spatial accessibility index improved from 125.625 to 97.625. Simultaneously, the weighted median spatial accessibility index increased from 2.811 to 3.929. Additionally, the SD of the potential crowdedness index for estimating workload disparity decreased from 10,040.36 to 5934.275 after optimization. The sensitivity analysis also showed a similar trend of reducing disparities. CONCLUSIONS: The reallocation of neuroendovascular specialists reduced regional disparities in spatial accessibility to healthcare, potential crowdedness index, and disparities between facilities. Our findings contribute to planning health policies to realize equity throughout the healthcare system.

Access to mechanical thrombectomy and ischemic stroke mortality in Japan: a spatial ecological study
Kazuki Ohashi, Toshiya Osanai, Kensuke Fujiwara, Takumi Tanikawa, Yuji Tani, Soichiro Takamiya, Hirotaka Sato, Yasuhiro Morii, Katsuhiko Ogasawara
Frontiers in Neurology, 14, Frontiers Media SA, 2023年09月05日
研究論文（学術雑誌）, Background

Advances in stroke treatment have greatly improved outcomes; however, disparities in access to treatment might increase. Achieving equitable access to stroke treatment is a health policy challenge, as rapid treatment is essential for positive outcomes. This ecological cross-sectional study aimed to determine the relationship between the disparities in spatial accessibility to mechanical thrombectomy (SAMT) and stroke mortality rates in Japan, hypothesizing that disparities in SAMT may increase the differences in stroke mortality between regions.

Methods

We used the average number of ischemic stroke (IS) deaths between 2020 and 2021 as the response variable; and SAMT, medical resources, and socioeconomic characteristics of each municipality as explanatory variables. A conditional autoregressive model was used to examine the association between the risk of stroke mortality and SAMT. The standardized mortality ratio (SMR) was mapped to understand the nationwide disparities in stroke mortality risk.

Results

The median number of IS deaths was 17.5 persons per year in the municipalities (2020 to 2021). The study also found that municipalities with low SAMT were located in the northern part of Japan. The non-spatial regression model results indicated that poor accessibility, a small proportion of bachelor’s degrees or higher, and a high proportion of workers in secondary industries were related to high IS mortality. Three models were evaluated using spatial analysis; Model 1 with accessibility indicators alone, Model 2 with medical resources added to Model 1, and Model 3 with socioeconomic characteristics added to Model 2. In Models 1 and 2, the population-weighted spatial accessibility index (PWSAI) showed a significant negative relationship with stroke mortality. However, this was not evident in Model 3. Mapping using Model 3 showed that the high-risk areas were predominantly located in northern Japan, excluding Hokkaido.

Conclusion

Access to mechanical thrombectomy was estimated, and regional differences were observed. The relationship between accessibility and IS mortality is unknown; however, regardless of accessibility, municipalities with a high proportion of workers in secondary industries and a small proportion with bachelor’s degrees or above are at risk of death from stroke.

Regional assessment of medical care provision system by principal component analysis.
Kazuki Ohashi, Arisa Abe, Kensuke Fujiwara, Naoki Nishimoto, Katsuhiko Ogasawara
Journal of family medicine and primary care, 12, 4, 734, 742, 2023年04月, ［国際誌］
英語, 研究論文（学術雑誌）, INTRODUCTION: The Japanese government has promoted policies ensuring standardized medical care across the secondary medical care areas (SMCAs); however, these efforts have not been evaluated, making the current conditions unclear. Multidimensional indicators could identify these differences; thus, this study examined the regional characteristics of the medical care provision system for 21 SMCAs in Hokkaido, Japan, and the changes from 1998 to 2018. MATERIALS AND METHODS: This study evaluated the characteristics of SMCAs by principal component analysis using multidimensional data related to the medical care provision system. Factor loadings and principal component scores were calculated, with the characteristics of each SMCA visually expressed using scatter plots. Additionally, data from 1998 to 2018 were analyzed to clarify the changes in SMCAs' characteristics. RESULTS: The primary and secondary principal components were Medical Resources and Geographical Factors, respectively. The Medical Resources components included the number of hospitals, clinics, and doctors, and an area's population of older adults, accounting for 65.28% of the total variance. The Geographical Factors components included the number of districts without doctors and the population and a land area of these districts, accounting for 23.20% of the variance. The accumulated proportion of variance was 88.47%. From 1998 to 2018, the area with the highest increase in Medical Resources was Sapporo, with numerous initial medical resources (-9.283 to -10.919). DISCUSSION: Principal component analysis summarized multidimensional indicators and evaluated SMCAs in this regional assessment. This study categorized SMCAs into four quadrants based on Medical Resources and Geographical Factors. Additionally, the difference in principal component scores between 1998 and 2018 emphasized the expanding gap in the medical care provision system among the 21 SMCAs.

Spatial-temporal analysis of cerebral infarction mortality in Hokkaido, Japan: an ecological study using a conditional autoregressive model.
Kazuki Ohashi, Toshiya Osanai, Kensuke Fujiwara, Takumi Tanikawa, Yuji Tani, Soichiro Takamiya, Hirotaka Sato, Yasuhiro Morii, Kyohei Bando, Katsuhiko Ogasawara
International journal of health geographics, 21, 1, 16, 16, 2022年10月31日, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Accessibility to stroke treatments is a challenge that depends on the place of residence. However, recent advances in medical technology have improved health outcomes. Nevertheless, the geographic heterogeneity of medical resources may increase regional disparities. Therefore, evaluating spatial and temporal influences of the medical system on regional outcomes and advanced treatment of cerebral infarction are important from a health policy perspective. This spatial and temporal study aims to identify factors associated with mortality and to clarify regional disparities in cerebral infarction mortality at municipality level. METHODS: This ecological study used public data between 2010 and 2020 from municipalities in Hokkaido, Japan. We applied spatial and temporal condition autoregression analysis in a Bayesian setting, with inference based on the Markov chain Monte Carlo simulation. The response variable was the number of deaths due to cerebral infarction (ICD-10 code: I63). The explanatory variables were healthcare accessibility and socioeconomic status. RESULTS: The large number of emergency hospitals per 10,000 people (relative risk (RR) = 0.906, credible interval (Cr) = 0.861 to 0.954) was associated with low mortality. On the other hand, the large number of general hospitals per 10,000 people (RR = 1.123, Cr = 1.068 to 1.178) and longer distance to primary stroke centers (RR = 1.064, Cr = 1.014 to 1.110) were associated with high mortality. The standardized mortality ratio decreased from 2010 to 2020 in Hokkaido by approximately 44%. Regional disparity in mortality remained at the same level from 2010 to 2015, after which it narrowed by approximately 5% to 2020. After mapping, we identified municipalities with high mortality rates that emerged in Hokkaido's central and northeastern parts. CONCLUSION: Cerebral infarction mortality rates and the disparity in Hokkaido improved during the study period (2010-2020). This study emphasized that healthcare accessibility through places such as emergency hospitals and primary stroke centers was important in determining cerebral infarction mortality at the municipality level. In addition, this study identified municipalities with high mortality rates that require healthcare policy changes. The impact of socioeconomic factors on stroke is a global challenge, and improving access to healthcare may reduce disparities in outcomes.

Analysis of predictors after partial splenic embolization for thrombocytopenia with liver cirrhosis.
Toru Ishikawa, Kazuki Ohashi, Erina Kodama, Takamasa Kobayashi, Motoi Azumi, Yujiro Nozawa, Akito Iwanaga, Tomoe Sano, Terasu Honma
Medicine, 101, 40, e30985, 2022年10月07日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Blood transfusion, splenectomy, and partial splenic embolization (PSE) are generally performed for thrombocytopenia in patients with cirrhosis. Recently, thrombopoietin (TPO) agonists have become available, and investigations of patients who would benefit from them are necessary. Therefore, it is important to understand the fluctuations in cytokine levels associated with PSE. Therefore, fluctuations in platelet-associated immunoglobulin G (PAIgG), interleukin 6 (IL-6), and TPO levels with PSE were analyzed in this study. The study included 110 patients with liver cirrhosis and thrombocytopenia, with the aim of improving platelet counts. Fluctuations in PAIgG, IL-6, and TPO levels were investigated. The average splenic embolization ratio was 58.0% in patients with PSE. The platelet count rose significantly from 6.95 [5.40, 8.60] × 104/mL to 14.05 [10.43, 18.05] × 104/mL (P < .01), IL-6 rose significantly from 3.56 [2.53, 7.33] pg/mL to 18.90 [9.17, 32.95] pg/mL (P < .01), TPO rose significantly from 0.82 [0.52, 1.21] fmol/mL to 1.58 [0.97, 2.26] fmol/mL (P < .01), and PAIgG decreased significantly from 64.20 [38.33, 118.75] ng/107 cells to 37.50 [22.25, 70.00] ng/107 cells (P < .01). On multivariate analysis of factors related to the rate of platelet increase with PSE, primary biliary cholangitis (B = 0.475, P < .01), splenic embolization ratio (B = 0.75, P < .01), IL-6 change ratio (B = 0.019, P < .01), and PAIgG change ratio (B = -0.325, P < .01) were significant. When attempting to improve thrombocytopenia with PSE, adequate splenic embolization needs to be obtained together with improvements in IL-6, PAIgG, and TPO levels. With unsatisfactory improvement in thrombocytopenia, TPO agonist administration was considered.

ERRATUM: Differences in spatial patterns of long-term care depending on severity in Hokkaido, Japan.
Kazuki Ohashi, Kensuke Fujiwara, Takumi Tanikawa, Kyohei Bando, Tomohiro Aoki, Katsuhiko Ogasawara
Geospatial health, 17, 2, 2022年08月29日, ［国際誌］
英語, 研究論文（学術雑誌）, Due to a mistake, the authors' affiliations were incorrectly reported in this article, published in Geospatial Health in 2022 (DOI: 10.4081/gh.2022.1077 - PMID: 35579241). The correct affiliations appear above. Geospatial Health DOI: 10.4081/gh.2022.1137.

Potential crowdedness of mechanical thrombectomy and cerebral infarction mortality in Japan: Application of inverted two-step floating catchment area method.
Kazuki Ohashi, Kensuke Fujiwara, Toshiya Osanai, Takumi Tanikawa, Kyohei Bando, Shojiro Yamasaki, Tomohiro Aoki, Songzi Gu, Katsuhiko Ogasawara
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 31, 9, 106625, 106625, 2022年07月04日, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVES: This study aimed to evaluate a stroke medical delivery system based on population coverage and the potential crowdedness index (PCI) of mechanical thrombectomy and investigate the relationship between PCI and cerebral infarction mortality in Japan. MATERIALS AND METHODS: This cross-sectional study defined 662 facilities and 1605 neurointerventionalists as supply, population aged 55 years or older as demand, and set the reachable area for demand as 120 min in driving time. Multiple regression analysis adjusted for spatial autocorrelation was used to examine the relationship between PCI and cerebral infarction mortality. RESULTS: In the 2020 data, 99% of the population aged 55 years or older had access to mechanical thrombectomy (≤120 min), and the PCI ranged from 5876 to 129838, with a median of 30426. From 2020 to 2035, the PCI is estimated to increase (30426 to 32510), decreasing after 2035 (32510 to 29469). The PCI distribution exhibited geographical heterogeneity. High PCI values emerged in eastern Japan. According to regression analysis, the increase in PCI by 1% led to an increase of 0.13% in standardized mortality ratio of cerebral infarction in men. However, PCI did not significantly correlate with cerebral infarction mortality in women. CONCLUSIONS: PCI for hospitals based on supply and demand was geographically heterogeneous in Japan. Optimization of PCI contributes equalization of mechanical thrombectomy provision system and may improve cerebral infarction mortality.

Differences in spatial patterns of long-term care depending on severity in Hokkaido, Japan.
Kazuki Ohashi, Kensuke Fujiwara, Takumi Tanikawa, Kyohei Bando, Tomohiro Aoki, Katsuhiko Ogasawara
Geospatial health, 17, 1, 2022年05月16日, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, The increasing demand for long-term care (LTC) among the ageing population is a serious problem worldwide, which has greatly increased also in Japan since the introduction of the LTC insurance system there. Since there is a difference between insurers with respect to the proportion of people needing LTC, this study aimed at clarifying the spatial patterns of LTC. Insurer (n=156) LTC data for the period 2012-2019 were obtained from Ministry of Health, Labour, and Welfare and those needing LTC were classified into three classes: total, mild and severe with ageand sex-adjusted proportions needing LTC. Global and local Moran’s I statistics were calculated for each 2-year period to clarify the trends of global and local spatial clusters. From 2012 to 2019, the mean proportion of mild class cases increased (10.6% to 11.6%), whereas that of severe class cases decreased slightly (5.9% to 5.7%). The spatial pattern of the proportion of each class revealed positive spatial autocorrelation. Based on analysis by local Moran’s I, differences in spatial patterns were emphasised between the mild and severe classes. In Hokkaido, High-High clusters of mild cases were identified in the central and southern parts and severe ones in the northern and southern parts. Spatial patterns differed depending on the LTC class. Some insurers had distinctly higher or lower certification rates than those of their neighbourhoods.

Histologic Analysis of Transjugular Liver Biopsy Specimens for Early Prediction of Prognosis in Acute Liver Failure
Toru Ishikawa, Kazuki Ohashi, Erina Kodama, Takamasa Kobayashi, Motoi Azumi, Yujiro Nozawa, Akito Iwanaga, Tomoe Sano, Terasu Honma
Gastro Hep Advances, 1, 3, 431, 436, Elsevier BV, 2022年, ［査読有り］
英語, 研究論文（学術雑誌）

Evaluation of and Intervention for Sarcopenia in Hepatology Departments: A Survey of Nurses in Japan
Kazuki Ohashi, Madoka Ito, Megumi Kawakubo, Ikue Sato
Healthcare, 9, 8, 1021, 1021, MDPI AG, 2021年08月09日, ［査読有り］, ［筆頭著者］
英語, 研究論文（学術雑誌）, Sarcopenia is associated with poor prognosis and decreased quality of life in patients with chronic liver disease (CLD). The present study aimed to clarify the dissemination of interventions such as evaluations, prevention efforts, and treatments for sarcopenia among patients in hepatology outpatient departments and wards in Japan, as well as examine the factors related to such dissemination. A cross-sectional study was performed involving nurses from hospitals accredited by the Japan Society of Hepatology. Participants completed a questionnaire regarding evaluations and interventions for sarcopenia in their department. Nurses from 72 outpatient departments and 162 wards provided responses to the questionnaire. Overall, 37.9% of outpatient departments and 37.6% of wards performed evaluations or interventions for sarcopenia. Outpatient departments and wards that evaluated sarcopenia or intervened held more workshops or training regarding sarcopenia than departments and wards that did not (outpatient departments: 52.0% vs. 12.2%, wards: 32.1% vs. 12.9%). Holding workshops or training regarding sarcopenia (outpatient departments; OR = 7.51, 95% confidence interval (CI): 2.12–26.6, wards; OR = 2.61, 95% CI: 1.11–6.15) was significantly associated with dissemination practices. These findings suggest that expanding knowledge of sarcopenia and developing practical skills among general nurses may aid in preventing sarcopenia among patients with CLD.

Optimal Skeletal Muscle Mass Index Cut-Off Values for Presarcopenia Evaluated by Computed Tomography against Dual-Energy X-ray Absorptiometry in Patients with Chronic Liver Disease.
Kazuki Ohashi, Toru Ishikawa, Asami Hoshii, Tamaki Hokari, Hirohito Noguchi, Mitsuyuki Suzuki, Hiroshi Hirosawa, Michitaka Imai, Yuta Mitobe, Toshiaki Yoshida
Journal of clinical medicine, 10, 7, 2021年04月01日, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, Although dual-energy X-ray absorptiometry (DXA) and body impedance analysis are commonly used to measure skeletal muscle mass (SMM), a computed tomography (CT) scan is preferred in clinical practice. We aimed to propose the cut-off values of skeletal muscle mass index (SMI) calculated using CT scans, using DXA as the reference method. We retrospectively assessed 589 patients with chronic liver disease. The SMI was assessed using appendicular SMM by DXA and total muscle area at the level of the third lumbar vertebra (L3) calculated by CT. The cut-off value was determined with reference to the Asian Working Group for Sarcopenia criteria. DXA identified 251 (42.6%) patients as having presarcopenia. In men, the cut-off value of SMI for presarcopenia was determined to be 45.471 cm2/m2, with an area under the curve (AUC) of 0.863 (95% confidence interval (CI): 0.823 to 0.903), and in women, this value was determined to be 35.170 cm2/m2, with an AUC of 0.846 (95% CI: 0.800 to 0.892). Cohen's kappa coefficient was 0.575 (95% CI: 0.485-0.665) in men and 0.539 (95% CI: 0.438-0.639) in women.

Effect of levocarnitine administration in patients with chronic liver disease.
Kazuki Ohashi, Toru Ishikawa, Asami Hoshii, Tamaki Hokari, Mitsuyuki Suzuki, Hirohito Noguchi, Hiroshi Hirosawa, Fujiko Koyama, Miki Kobayashi, Shiori Hirosawa, Kaede Sugiyama, Yuta Mitobe, Toshiaki Yoshida
Experimental and therapeutic medicine, 20, 5, 94, 94, 2020年11月, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, L-carnitine administration was reported to improve sarcopenia in patients with cirrhosis. However, the amount of evidence from previous studies is not sufficient. The present study aimed to clarify the effect of levocarnitine (L-carnitine) administration on body composition in patients with chronic liver disease (CLD). In the present study, 85 patients with L-carnitine administration and 87 control patients were enrolled and divided them into two groups, the L-carnitine administration group (LAG, n=44) and the without L-carnitine administration (controls, n=44) group, by using propensity score matching for age, sex, body mass index (BMI) and serum albumin. Δ skeletal muscle mass index (SMI)/year, Δ intramuscular adipose tissue content (IMAC)/year and Δ bone mineral density (BMD)/year were examined during L-carnitine administration. Each parameter was measured by computed tomography (CT) or dual-energy X-ray absorptiometry. The median age overall was 69 years (IQR, 64.0, 75.0); 36 were men and 52 were women. The median SMI was 37.4 cm2/m2 (IQR, 34.01, 44.34). The initial CT scans showed similar median values of SMI for the two groups [37.74 (34.17, 43.58) and 37.16 (33.83, 44.34), P=0.67]. However, the median ΔSMI/year for the LAG and controls were 0.95% (-3.07, 6.10) and -2.34% (-5.34, 0.53), respectively (P=0.003). The median Δ whole body BMD/year for the LAG and controls were -0.24% (-1.20, 0.91) and -1.04% (-2.16, 0.47), respectively (P=0.038). The median ΔIMAC/year and Δ lumbar spine BMD were not significantly different between the LAG and controls. L-carnitine administration may prevent the loss of skeletal muscle mass and BMD; therefore, it may be used as a new treatment option for osteoporosis and sarcopenia in patients with CLD.

Skeletal Muscle Index at Intensive Care Unit Admission Is a Predictor of Intensive Care Unit-Acquired Weakness in Patients With Sepsis.
Yuta Mitobe, Shinichiro Morishita, Kazuki Ohashi, Sayuri Sakai, Mieko Uchiyama, Hansani Abeywickrama, Etsuko Yamada, Yuko Kikuchi, Masakazu Nitta, Tadayuki Honda, Hiroshi Endoh, Shinji Kimura, Shuhei Sakano, Yu Koyama
Journal of clinical medicine research, 11, 12, 834, 841, 2019年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: Intensive care unit-acquired weakness (ICU-AW) can be diagnosed using the Medical Research Council (MRC) score. However, such scoring may not be possible in ICU patients who may be sedated or delirious or have encephalopathy. Currently, a quantitative assessment of the cross-sectional area of the muscle is available to assess changes in skeletal muscle mass using computed tomography (CT) images. This assessment calculates the skeletal muscle index (SMI) (cm2/m2) by dividing the cross-sectional area (cm2) of the skeletal muscle at the level of the third lumbar vertebra by the square of the patient's height (m2) on CT. This study assessed the effectiveness of SMI, as measured by abdominal CT scans, in predicting the onset of ICU-AW in patients with sepsis admitted to the ICU. Methods: We examined septic ICU patients admitted to the Niigata University Hospital ICU during 2012 - 2017 under mechanical ventilation. Patients were retrospectively divided into two groups by MRC score at ICU discharge: group AW comprised patients with an MRC score < 48, and group non-AW (NAW) comprised the remaining patients. Clinicopathological factors at ICU admission such as age, gender, underlying disease, body mass index, and SMI were compared between the two groups. Statistical analyses were performed using the Mann-Whitney U test, Fisher's exact test, receiver operator characteristic (ROC) analysis and multivariate analysis. Results: A total of 31 septic patients were examined, and 23 patients met the criteria for ICU-AW. The prevalence of women was significantly higher in group AW (P < 0.05). All clinical factors, except for gender, were not significantly different between the two groups. SMI was significantly lower in group AW than in group NAW (P < 0.05). ROC analysis revealed that the cut-off value of SMI for predicting ICU-AW was 44.1, and the multivariate analysis revealed that only low SMI was a significant factor in predicting ICU-AW (P < 0.05). Conclusions: Our results show that SMI measurement at ICU admission is a valid predictive factor for ICU-AW progression in septic patients.

Relationship between pre-sarcopenia and quality of life in patients with chronic liver disease: a cross-sectional study.
Kazuki Ohashi, Toru Ishikawa, Michitaka Imai, Mitsuyuki Suzuki, Asami Hoshii, Hiroko Abe, Fujiko Koyama, Tomomi Nakano, Aya Ueki, Hirohito Noguchi, Erina Hasegawa, Shiori Hirosawa, Miki Kobayashi, Hiroshi Hirosawa, Kaede Sato, Miyu Munakata, Toshiaki Yoshida
European journal of gastroenterology & hepatology, 31, 11, 1408, 1413, 2019年11月, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, AIM: This study aimed to clarify the relationship between pre-sarcopenia (PS) and quality of life (QOL) in patients with chronic liver disease (CLD). PATIENTS AND METHODS: This cross-sectional study evaluated 335 patients with CLD. PS was diagnosed on the basis of the assessment criteria by the Japan Society of Hepatology. QOL was evaluated using the short form-36. RESULTS: Patients' mean age was 69.52 ± 10.17 years, and 169 (50.4%) participants were men. The prevalence of PS was 53.7%. Patients were divided into the PS and non-pre-sarcopenia (NPS) groups. Patients in the PS group were older (71.84 ± 9.78 vs. 66.81 ± 9.97, P < 0.01) and mostly women (65.2 vs. 37.8%, P < 0.01) compared with those in the NPS group. QOL, physical function (38.30 ± 17.63 vs. 44.02 ± 14.76, P < 0.01), physical role functioning (RP) (40.63 ± 15.38 vs. 44.88 ± 13.89, P < 0.01), and bodily pain (BP) (48.42 ± 11.45 vs. 51.24 ± 10.19, P = 0.02) were significantly lower in the PS group than in the NPS group. Logistic regression analyses identified that the independent predictive factors for PS were female sex (odds ratio: 3.16, 95% confidence interval: 2.01-4.98; P < 0.01) and RP (odds ratio: 1.97, 95% confidence interval: 1.24-3.12; P < 0.01). CONCLUSION: QOL characteristics of PS patients with CLD were low physical function, RP, and BP in short form-36. In addition, social role functioning was low in the PS patients aged 65-74 years, whereas RP and BP were low in those aged at least 75 years. Female sex and RP were independent predictors of PS according to the multivariate analysis. Maintaining and increasing muscle mass in patients with CLD may contribute toward improving physical QOL.

Efficacy of Physical Activity in Prevention of Muscle Weakness in Patients With Chronic Liver Disease.
Kazuki Ohashi, Toru Ishikawa, Asami Hoshii, Tamaki Hokari, Mitsuyuki Suzuki, Yuta Mitobe, Etsuko Yamada, Hansani Madushika Abeywickrama, Yuko Kikuchi, Hirohito Noguchi, Hiroshi Hirosawa, Yu Koyama
Journal of clinical medicine research, 11, 10, 711, 719, 2019年10月, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: Sarcopenia is a prognostic factor for patients with liver cirrhosis and hepatocellular carcinoma, and it affects the onset of hepatic encephalopathy. Therefore, the prevention of sarcopenia contributes to the improvement of the prognosis of patients with chronic liver disease (CLD). We focused on changes of hand grip strength (HGS), one of the indicators of sarcopenia. However, there are little data investigating the impact of physical activity (PA) on HGS in patients with CLD. This study aimed to clarify whether PA contributes to the prevention of muscle weakness in patients with CLD. Methods: This was a prospective observational study. We examined the effect of PA on changes in HGS from the baseline to the endpoint in each group. Metabolic equivalents-hour/week (METs-h/w) was used to evaluate PA. In total, 183 outpatients with CLD were analyzed. We divided participants into four groups (low PA in younger patients (n = 20), high PA in younger patients (n = 33), low PA in elderly patients (n = 47), and high PA in elderly patients (n = 83)). Results: Fifty-eight percent of patients were men, and the median (interquartile range) age was 69.0 (63.0, 75.0) years. The most common etiology of liver disease was hepatitis C (38%). The frequency of living alone and low exercise habit was significantly high, and sarcopenia was more obvious in elderly patients with low PA than in those with high PA. Additionally, the elderly with low PA showed significantly reduced HGS compared to that of the elderly with high PA (-1.00 (-2.27, 0.55) kg vs. 0.10 (-1.40, 1.10) kg, P < 0.05). However, changes in HGS in younger patients were not significant (-0.02 (1.83, 1.47) kg vs. 0.25 (-2.45, 2.05) kg, P = 0.96). Logistic regression analyses identified PA as the independent factor for prevention of decrease in HGS (odds ratio: 1.91, 95% confidence interval: 1.00 - 3.62, P = 0.049). Conclusions: Young patients with low PA were characterized by a long sedentary time; however, there was no loss of HGS. In contrast, elderly patients with CLD and low PA had significantly reduced HGS compared to that in elderly patients with CLD and high PA.

Relationship Between Sarcopenia and Both Physical Activity and Lifestyle in Patients With Chronic Liver Disease.
Kazuki Ohashi, Toru Ishikawa, Asami Hoshi, Mitsuyuki Suzuki, Yuta Mitobe, Etsuko Yamada, Hansani Madushika Abeywickrama, Nao Seki, Chikayo Koyama, Hagiko Aoki, Yu Koyama
Journal of clinical medicine research, 10, 12, 920, 927, 2018年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Background: Sarcopenia can affect the prognosis of patients with cirrhosis or hepatocellular carcinoma. Exercise therapy and nutritional therapy are carried out to prevent processing sarcopenia. In addition, changing lifestyle is also important. However, there are only few reports on the physical activities (PAs) and lifestyle of chronic liver disease patients and their association with sarcopenia. The aim of this study is to examine the relationship between sarcopenia in patients with chronic liver disease and both PA and lifestyle. Methods: A total of 214 out-patients with chronic liver disease were enrolled into the present study. All patients were evaluated for with or without sarcopenia based on the sarcopenia diagnostic criteria of the Japan Society of Hepatology. Then, patient's characteristics and laboratory parameters were divided into two groups with or without sarcopenia and compared. In continuous variable with significant difference in univariate analysis, cut-off value was calculated by receiver operating characteristic curve. We determined which factors were associated with sarcopenia in univariate analyses, and variables significant in the univariate analyses were entered in a multivariable logistic regression model. Results: Patients with chronic liver disease had a prevalence of sarcopenia of 12.6% in this study. Sarcopenia patients were older (76.48 ± 6.69 versus 66.97 ± 11.19 years old; P < 0.01), had lower body mass index (BMI) (20.84 ± 2.44 versus 23.76 ± 3.72 kg/m2; P < 0.01), lower PA (6.6 (2.34 - 19.90) versus 16.5 (6.60 - 41.23) metabolic equivalents (METs)-h/week; P < 0.01) and longer total time sitting and lying on the day (7.43 ± 4.09 versus 5.68 ± 3.17 h/day; P = 0.01); retirement status (81.5% versus 48.1%; P < 0.01) and low frequency of driving (40% versus 20%; P = 0.01) were higher in sarcopenia patients than in non-sarcopenia patients. The independent predictive factors of sarcopenia, analyzed with logistic regression, were age (odds ratio (OR): 5.89, 95% confidence interval (CI): 2.15 - 16.20; P < 0.01), BMI (OR: 4.77, 95% CI: 1.87 - 12.10; P < 0.01) and PA (OR: 3.65, 95% CI: 2.15 - 16.20; P < 0.01). Conclusion: Sarcopenia patients' lifestyle characteristics were longer sedentary time and low frequency of driving, high retirement. Independent predictive factors of sarcopenia were elderly, low BMI and low PA. For these patients, intervention in the lifestyle for prevention of sarcopenia may be effective for patients with chronic liver disease.

Micronutrient Status in Sri Lanka: A Review.
Hansani Madushika Abeywickrama, Yu Koyama, Mieko Uchiyama, Utako Shimizu, Yuka Iwasa, Etsuko Yamada, Kazuki Ohashi, Yuta Mitobe
Nutrients, 10, 11, 2018年10月27日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Micronutrients include vitamins, minerals and, trace elements that are required in minute quantities but play a vital role in normal human growth, development and physiological functioning. Micronutrient deficiencies, also known as hidden hunger, are a global issue, with particularly high prevalence rates in developing countries. Currently, Sri Lanka is experiencing the double burden of over- and undernutrition. This review describes the micronutrient status of Sri Lanka based on results of national surveys and related articles published from 2000. The available data suggest a higher prevalence of iron, zinc, calcium, folate, and vitamin A deficiencies. The prevalence of iodine deficiency has declined gradually following the implementation of a universal salt iodization program. Iron deficiency is the most common cause of anemia and low red blood cell indices. Females are more vulnerable to micronutrient deficiencies than males. The coexistence of multiple micronutrient deficiencies and concurrent macro- and micronutrient deficiencies is common. Studies have shown an association between micronutrient deficiencies and different demographic, socioeconomic, and dietary factors. Therefore, there is a need for comprehensive studies, nutritional policies, and nationwide intervention programs in Sri Lanka to improve the micronutrient status of the population.

Health-related quality of life on the clinical course of patients with chronic hepatitis C receiving daclatasvir/asunaprevir therapy: A prospective observational study comparing younger (<70) and elderly (≥70) patients.
Ohashi K, Ishikawa T, Suzuki M, Abe H, Koyama F, Nakano T, Ueki A, Noguchi H, Hasegawa E, Hirosawa S, Kobayashi M, Hirosawa H, Sato K, Fukazawa T, Maruyama Y, Yoshida T
Experimental and therapeutic medicine, 15, 1, 970, 976, Spandidos Publications, 2018年01月, ［査読有り］, ［筆頭著者］, ［国際誌］
英語, 研究論文（学術雑誌）, Interferon-free direct acting antiviral agent regimens for chronic hepatitis C (CHC) have been developed. These regimens have shown a high rate of sustained virologic response (SVR), and a reduction in side effects during treatment is also anticipated. However, the impact of the regimens on health-related quality of life (HRQOL) and side effects during treatment is not fully understood. The purpose of the present study was to evaluate HRQOL in the clinical course of patients with CHC receiving daclatasvir/asunaprevir (DCV/ASV) therapy using the Short Form-36 (SF-36) method. Twenty-eight patients with CHC receiving DCV/ASV therapy were analyzed in the present study, and HRQOL was measured by SF-36. Patients were asked to fill out the SF-36 prior to therapy (baseline), following 12 weeks of therapy, at the end of treatment and at SVR week 24 (SVR24) to evaluate HRQOL. Laboratory data were also investigated during the same period, and associations between these results and SF-36 were investigated. Aspartate aminotransferase, alanine aminotransferase, serum albumin, α-fetoprotein, platelet counts and Fibrosis (Fib)-4 index were all significantly improved at each time point when compared with baseline. With regard to alterations in HRQOL during therapy, the ≥70-year-old group displayed a significantly greater improvement in physical functioning during the period between baseline and 12 weeks when compared with the <70-year-old group. In the analysis of the SF-36 differences within each group, general health improved significantly in the ≥70-year-old group, as well as albumin levels. In addition, Fib-4-index significantly improved at all time points (12 and 24 weeks, and SVR24) when compared with baseline in the ≥70-year-old group. Therefore, DCV/ASV therapy may improve HRQOL and hepatic functional reserve, particularly in elderly patients.

Evaluation of the health-related quality of life using the 36-item short form health survey in patients with chronic hepatitis C receiving pegylated interferon/ribavirin/telaprevir triple treatment
Mitsuyuki Suzuki, Toru Ishikawa, Ai Sakuma, Satoshi Abe, Hiroko Abe, Fujiko Koyama, Tomomi Nakano, Aya Ueki, Hirohito Noguchi, Erina Hasegawa, Shiori Yamagata, Miki Kobayashi, Kazutaka Ohashi, Hiroshi Hirosawa, Takako Fukazawa, Yuka Maruyama, Toshiaki Yoshida
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 12, 5, 3353, 3358, SPANDIDOS PUBL LTD, 2016年11月, ［査読有り］
英語, 研究論文（学術雑誌）, The rate of sustained virologic response (SVR) has increased in patients with chronic hepatitis C (CHC; genotype 1) since triple treatment with pegylated interferon (PEG-IFN), ribavirin (RBV) and telaprevir (TVR) was included in Japanese health insurance. However, side effects such as high-grade anemia and skin disorders means it is important to investigate the extent to which quality of life (QOL) is maintained during treatment. The impact on health-related (HR) QOL, as a result of TVR-based triple treatment was investigated long-term (48 weeks) in 34 patients (18 men, 16 women) following TVR-based triple treatment, using the 36-item short form health survey (SF-36). While scores for physical health were significantly lower during treatment, an improvement was seen in patients who showed complete response to treatment from 12 weeks following treatment (P< 0.05). HRQOL improved significantly following completion of TVR-based triple treatment in these complete-responders, with higher scores compared with those prior to treatment. Anemia and skin symptoms appeared frequently during treatment and scores for physical health dropped. Particular care needs to be taken in regards to the management of side effects during TVR treatment. Further evaluations using the SF-36 may help in controlling doses to achieve SVR.

安心して子育てできる地域を創ろう-障害や医療的ケアのある子どもと家族に焦点をあてて- 医療的ケア児とその家族に必要なケアやサービス アクセスと地域差について
大橋 和貴, 小児保健研究, 83, 講演集, 96, 96, 2024年05月
(公社)日本小児保健協会, 日本語

訪問看護サービスの空間的アクセシビリティに関する探索的研究　　　　　　　　　　　　　　　
大橋 和貴, 金 絢加, 佐藤 三穂, 鷲見 尚己, 谷川 琢海, 小笠原 克彦, 医療情報学連合大会論文集, 43回, 744, 746, 2023年11月
(一社)日本医療情報学会, 日本語

二次救命処置演習における看護学生の学習経験 テキストマイニングによる分析　　　　　　　　　　　　　　　
川合 咲穂, 大橋 和貴, 金 絢加, 鷲見 尚己, 鈴木 健太郎, 佐藤 三穂, 医療情報学連合大会論文集, 43回, 1040, 1044, 2023年11月
(一社)日本医療情報学会, 日本語

慢性肝疾患患者におけるオステオサルコペニアの臨床的特徴
星井旭美, 石川達, 大橋和貴, 八巻諒人, 寺井菜々子, 飯塚明彦, 本間照, 日本消化器病学会雑誌(Web), 120, 2023年

北海道における訪問看護サービスの地理的アクセシビリティについて 在宅医療圏別の評価　　　　　　　　　　　　　　　
大橋 和貴, 藤原 健祐, 谷川 琢海, 坂東 恭平, 森井 康博, 小笠原 克彦, 医療情報学連合大会論文集, 42回, 771, 772, 2022年11月
(一社)日本医療情報学会, 日本語

北海道における一次脳卒中センターの均てん化シミュレーション　　　　　　　　　　　　　　　
坂東 恭平, 大橋 和貴, 藤原 健祐, 谷川 琢海, 長内 俊也, 小笠原 克彦, 医療情報学連合大会論文集, 42回, 777, 778, 2022年11月
(一社)日本医療情報学会, 日本語

急性期脳梗塞患者の搬送方法が治療へのアクセシビリティに及ぼす影響 地理情報システムを用いたシミュレーション　　　　　　　　　　　　　　　
森井 康博, 長内 俊也, 藤原 健祐, 高宮 宗一朗, 坂東 恭平, 谷川 琢海, 谷 祐児, 佐藤 広崇, 大橋 和貴, 石川 智基, 小笠原 克彦, 医療情報学連合大会論文集, 42回, 779, 780, 2022年11月
(一社)日本医療情報学会, 日本語

肝細胞癌ダブルプラチナ動注化学療法時の悪心嘔吐に対するNK-1受容体拮抗薬の効果とQOL評価についての検討　　　　　　　　　　　　　　　
鈴木 光幸, 石川 達, 大橋 和貴, 野口 博人, 廣澤 宏, 星井 旭美, 本間 照, 日本消化器病学会雑誌, 119, 臨増大会, A790, A790, 2022年10月
(一財)日本消化器病学会, 日本語

経皮的脳血栓回収療法を実施する医師を新規配置した場合における費用対効果 北海道を対象とした検討　　　　　　　　　　　　　　　
森井 康博, 長内 俊也, 谷 祐児, 藤原 健祐, 坂東 恭平, 石川 智基, 高宮 宗一朗, 谷川 琢海, 大橋 和貴, 佐藤 広崇, 小笠原 克彦, 日本医療・病院管理学会誌, 59, Suppl., 186, 186, 2022年09月
(一社)日本医療・病院管理学会, 日本語

血栓回収療法の適応拡大にともなう医師負担を考慮した,血管内治療提供体制の構築
長内俊也, 大橋和貴, 坂東恭平, 森井康博, 藤原健祐, 谷川琢海, 小笠原克彦, 藤村幹, 脳血管内治療(Web), 7, Supplement, 2022年

慢性肝疾患患者に対するサルコペニア診断を目的としたcomputed tomographyによる基準値算出の検討　　　　　　　　　　　　　　　
星井 旭美, 石川 達, 大橋 和貴, 帆苅 環, 今井 径卓, 小林 功, 吉田 俊明, 日本消化器病学会雑誌, 118, 臨増大会, A700, A700, 2021年10月
(一財)日本消化器病学会, 日本語

当院における慢性肝疾患患者の血清亜鉛値とプレサルコペニアの関連性について　　　　　　　　　　　　　　　
鈴木 光幸, 石川 達, 星井 旭美, 大橋 和貴, 廣澤 宏, 野口 博人, 吉田 俊明, 日本消化器病学会雑誌, 118, 臨増大会, A765, A765, 2021年10月
(一財)日本消化器病学会, 日本語

Fuzzy-C-Means法を用いた痛みに関する看護用語を数値化
HAN Feng, ZHANG ZiHeng, 大橋和貴, ZHANG HongJian, 小笠原克彦, 医療情報学連合大会論文集(CD-ROM), 41st, 2021年

医学文献マイニングにおける痛みに関する看護用語抽出の看護用語と一般後の比率の検討
ZHANG Ziheng, HAN Feng, 大橋和貴, ZHANG Hongjian, 小笠原克彦, 医療情報学連合大会論文集(CD-ROM), 41st, 2021年

北海道における要介護(要支援)認定率と介護サービス利用状況の空間パターン分析
大橋和貴, 坂東恭平, 小笠原克彦, 医療情報学連合大会論文集(CD-ROM), 41st, 2021年

慢性肝疾患におけるL-carnitineの骨格筋量、骨密度への有用性　　　　　　　　　　　　　　　
大橋 和貴, 石川 達, 帆苅 環, 星井 旭美, 鈴木 光幸, 野口 博人, 廣澤 宏, 植木 文, 小林 美樹, 廣澤 詩織, 水科 美紀, 杉山 かえで, 今井 径卓, 吉田 俊明, 日本消化器病学会雑誌, 117, 臨増大会, A741, A741, 2020年10月
(一財)日本消化器病学会, 日本語

慢性肝疾患患者の身体活動量とその関連要因　　　　　　　　　　　　　　　
大橋 和貴, 日本慢性看護学会誌, 14, Suppl., 72, 72, 2020年09月
日本慢性看護学会, 日本語

慢性肝疾患におけるサルコペニア予防とメディカルスタッフの役割　　　　　　　　　　　　　　　
大橋 和貴, 第72回 済生会学会, 2020年02月, ［招待有り］, ［筆頭著者］

胃切除術パスにおける消化管運動機能に対する処置介入の必要性　　　　　　　　　　　　　　　
本間 由佳, 簑口 紗織, 大橋 和貴, 羽田 千代子, 内藤 秀子, 高野 留美, 佐藤 志津子, 武者 信行, 車田 茂徳, 日本クリニカルパス学会誌, 21, 4, 416, 416, 2019年12月
(一社)日本クリニカルパス学会, 日本語

慢性肝疾患患者における身体活動量と握力の変化に関する検討
大橋 和貴, 石川 達, 星井 旭美, 鈴木 光幸, 山田 悦子, 菊池 裕子, Abeywickrama Hansani, 水戸部 優太, 小山 千加代, 関 奈緒, 青木 萩子, 小山 諭, 日本消化器病学会雑誌, 116, 臨増大会, A803, A803, 2019年11月
(一財)日本消化器病学会, 日本語

慢性肝疾患患者におけるナルフラフィン内服後の睡眠障害・そう痒感・QOL評価に関する検討
廣澤 宏, 石川 達, 今井 径卓, 阿部 弘子, 小山 富士子, 中野 ともみ, 植木 文, 長谷川 江梨名, 野口 博人, 大橋 和貴, 廣澤 詩織, 小林 美樹, 鈴木 光幸, 佐藤 かえで, 帆苅 環, 星井 旭美, 吉田 俊明, 日本消化器病学会雑誌, 116, 臨増大会, A804, A804, 2019年11月
(一財)日本消化器病学会, 日本語

慢性肝疾患患者における体組成から見た臨床的特徴
星井 旭美, 石川 達, 帆苅 環, 八巻 諒人, 大橋 和貴, 今井 径卓, 小林 功, 吉田 俊明, 日本消化器病学会雑誌, 116, 臨増大会, A848, A848, 2019年11月
(一財)日本消化器病学会, 日本語

慢性肝疾患患者における骨密度減少の臨床的検討
帆苅 環, 石川 達, 星井 旭美, 八巻 諒人, 大橋 和貴, 今井 径卓, 小林 功, 吉田 俊明, 日本消化器病学会雑誌, 116, 臨増大会, A848, A848, 2019年11月
(一財)日本消化器病学会, 日本語

慢性肝疾患患者における二重エネルギーX線吸収測定(DXA)法によるサルコペニアと骨粗鬆症罹患率の検討
八巻 諒人, 石川 達, 帆苅 環, 星井 旭美, 大橋 和貴, 今井 径卓, 小林 功, 吉田 俊明, 日本消化器病学会雑誌, 116, 臨増大会, A849, A849, 2019年11月
(一財)日本消化器病学会, 日本語

Skeletal Muscle Index at ICU (Intensive Care Unit) Admission is Valid for Predicting the Progression of ICU-Acquired Weakness (ICU-AW) for Septic Patients
Yuta Mitobe, Y Koyama, S Sakai, M Uchiyama, H Abeywickrama, E Yamada, K Ohashi, Y Kikuchi, M Nitta, T Honda, H Endo, Clinical Nutrition, 2019年09月, ［査読有り］
英語, 研究発表ペーパー・要旨（国際会議）

骨格筋指数を用いたICU‐AWの早期予測に関する後ろ向き研究
水戸部優太, 小山諭, 内山美枝子, 大橋和貴, 山田悦子, ハンサニ アベイウィックレマ, 坂井さゆり, 菊池裕子, 森下慎一郎, 外科と代謝・栄養, 53, 3, 76, 76, 2019年06月15日
日本外科代謝栄養学会, 日本語

慢性肝疾患患者の身体活動量と握力の変化　　　　　　　　　　　　　　　
大橋和貴, 小山諭, 石川達, 星井旭美, 鈴木光幸, 水戸部優太, 山田悦子, 菊池裕子, Hansani Abeywickrama, 小山千加代, 関奈緒, 青木萩子, 第６回日本サルコペニア・悪液質・消耗性疾患研究会, 2019年04月
日本語, 研究発表ペーパー・要旨（全国大会，その他学術会議）

重症患者への早期リハビリテーションの有効性と骨格筋指数を用いたICU-AW発症予測　　　　　　　　　　　　　　　
水戸部優太, 小山諭, 森下慎一郎, 大橋和貴, 山田悦子, Hansani Abeywickrama, 菊池裕子, 坂井さゆり, 内山美枝子, 第6回日本サルコペニア・悪液質消耗性疾患研究会, 2019年04月
日本語, 研究発表ペーパー・要旨（全国大会，その他学術会議）

慢性肝疾患患者における掻痒感と睡眠障害に関する検討
植木文, 石川達, 今井径卓, 阿部弘子, 小山富士子, 中野ともみ, 長谷川江梨名, 野口博人, 大橋和貴, 廣澤詩織, 小林美樹, 丸山由華, 廣澤宏, 鈴木光幸, 深澤尚子, 佐藤かえで, 吉田俊明, 肝臓, 59, Supplement 3, A902, 2018年11月25日
日本語

C型肝炎に対するインターフェロンフリー治療症例のSF-36によるQOL評価の検討　　　　　　　　　　　　　　　
宗形 美祐, 石川 達, 野口 博人, 阿部 弘子, 小山 富士子, 中野 ともみ, 植木 文, 廣澤 詩織, 小林 美樹, 長谷川 江梨名, 大橋 和貴, 丸山 由華, 廣澤 宏, 鈴木 光幸, 深澤 尚子, 吉田 俊明, 日本消化器病学会雑誌, 115, 臨増大会, A736, A736, 2018年10月
(一財)日本消化器病学会, 日本語

プレサルコペニア合併慢性肝疾患患者のQOLの検討　　　　　　　　　　　　　　　
大橋 和貴, 石川 達, 星井 旭美, 鈴木 光幸, 阿部 弘子, 中野 ともみ, 小山 富士子, 植木 文, 廣澤 詩織, 小林 美樹, 野口 博人, 宗形 美佑, 佐藤 かえで, 廣澤 宏, 今井 径卓, 吉田 俊明, 日本消化器病学会雑誌, 115, 臨増大会, A809, A809, 2018年10月
(一財)日本消化器病学会, 日本語

慢性肝疾患患者におけるサルコペニア合併例の特徴　　　　　　　　　　　　　　　
大橋 和貴, 石川 達, 星井 旭美, 小山 諭, 青木 萩子, 日本消化器病学会雑誌, 115, 臨増大会, A809, A809, 2018年10月
(一財)日本消化器病学会, 日本語

慢性肝疾患患者のかゆみに対するナルフラフィンの治療効果とQOLの検討　　　　　　　　　　　　　　　
鈴木 光幸, 石川 達, 廣澤 宏, 大橋 和貴, 小山 富士子, 吉田 俊明, 日本消化器病学会雑誌, 115, 臨増大会, A810, A810, 2018年10月
(一財)日本消化器病学会, 日本語

重症度,医療・看護必要度を用いた退院調整介入時期の検討
大橋和貴, 石山綾, 日本医療マネジメント学会雑誌, 19, Supplement, 303, 2018年05月07日
日本語

C型肝疾患に対するDaclatasvir/Asunaprevir療法におけるSF-36を用いたQOL評価の検討　　　　　　　　　　　　　　　
大橋 和貴, 石川 達, 今井 径卓, 阿部 弘子, 中野 ともみ, 植木 文, 小山 富士子, 野口 博人, 廣澤 詩織, 小林 美樹, 高 昌良, 吉田 俊明, 日本消化器病学会雑誌, 114, 臨増大会, A845, A845, 2017年09月
(一財)日本消化器病学会, 日本語

インターフェロンフリーに対するSF-36によるQOL評価の検討　　　　　　　　　　　　　　　
野口 博人, 石川 達, 阿部 弘子, 小山 富士子, 中野 ともみ, 植木 文, 山形 詩織, 小林 美樹, 長谷川 江梨名, 大橋 和貴, 丸山 由華, 廣澤 宏, 鈴木 光幸, 深澤 尚子, 佐藤 かえで, 吉田 俊明, 日本消化器病学会雑誌, 114, 臨増大会, A846, A846, 2017年09月
(一財)日本消化器病学会, 日本語

慢性肝疾患に対するナルフラフィン投与患者のそう痒感評価とQOL改善効果についての検討　　　　　　　　　　　　　　　
廣澤 詩織, 石川 達, 今井 径卓, 阿部 弘子, 小山 富士子, 中野 ともみ, 植木 文, 野口 博人, 小林 美樹, 長谷川 江梨名, 大橋 和貴, 丸山 由華, 廣澤 宏, 鈴木 光幸, 深澤 尚子, 佐藤 かえで, 吉田 俊明, 日本消化器病学会雑誌, 114, 臨増大会, A854, A854, 2017年09月
(一財)日本消化器病学会, 日本語

慢性肝疾患患者におけるChronic liver disease questionnairesと包括的QOL評価であるSF-36の相関性の評価　　　　　　　　　　　　　　　
野口 博人, 石川 達, 阿部 弘子, 小山 富士子, 中野 ともみ, 植木 文, 山形 詩織, 小林 美樹, 長谷川 江梨名, 大橋 和貴, 丸山 由華, 廣澤 宏, 鈴木 光幸, 深澤 尚子, 佐藤 かえで, 吉田 俊明, 日本消化器病学会雑誌, 114, 臨増大会, A855, A855, 2017年09月
(一財)日本消化器病学会, 日本語

レボカルニチン投与患者における栄養評価とQOLの検討
大橋和貴, 石川達, 植木文, 小林美樹, 山形詩織, 深澤尚子, 阿部弘子, 小山富士子, 中野ともみ, 野口博人, 鈴木光幸, 廣澤宏, 丸山由華, 肝臓, 57, Supplement 3, A769, 2016年10月25日
日本語

当院慢性肝疾患患者のかゆみに対するナルフラフインの治療効果についての検討
鈴木光幸, 石川達, 廣澤宏, 大橋和貴, 吉田俊明, 肝臓, 57, Supplement 3, A766, 2016年10月25日
日本語

Peg‐IFNα/SMV/RBV3剤併用療法中にIFN‐βへ切り替え後うつ症状が改善した2例
大橋和貴, 石川達, 小林美樹, 山形詩織, 肝臓, 57, Supplement 3, A774, 2016年10月25日
日本語

多職種によるチーム医療としての肝臓病教室からいかに患者の治療意欲向上に向けられるか―経済的側面からの情報提供も目指して―
植木文, 石川達, 丸山由華, 阿部弘子, 小山富士子, 中野ともみ, 野口博人, 長谷川江梨名, 小林美樹, 山形詩織, 大橋和貴, 廣澤宏, 鈴木光幸, 深澤尚子, 吉田俊明, 肝臓, 57, Supplement 3, A767, 2016年10月25日
日本語

IFN-based第二世代DAA3剤併用療法に対するSF-36によるQOL評価の検討　　　　　　　　　　　　　　　
大橋 和貴, 石川 達, 阿部 聡司, 阿部 弘子, 中野 ともみ, 植木 文, 小山 富士子, 長谷川 江梨名, 野口 博人, 山形 詩織, 小林 美樹, 渡邊 貴之, 吉田 俊明, 日本消化器病学会雑誌, 113, 臨増大会, A737, A737, 2016年09月
(一財)日本消化器病学会, 日本語

Daclatasvir/Asunaprevir療法におけるSF-36を用いたQOL評価の検討　　　　　　　　　　　　　　　
大橋 和貴, 石川 達, 阿部 聡司, 阿部 弘子, 中野 ともみ, 植木 文, 小山 富士子, 長谷川 江梨名, 野口 博人, 山形 詩織, 小林 美樹, 渡邊 貴之, 吉田 俊明, 日本消化器病学会雑誌, 113, 臨増大会, A739, A739, 2016年09月
(一財)日本消化器病学会, 日本語

肝予備能改善を目ざした分岐鎖アミノ酸(branched-chain amino acids;BCAA)含有経腸栄養剤アドヒアランス向上のための服用評価　　　　　　　　　　　　　　　
小林 美樹, 石川 達, 阿部 弘子, 小山 富士子, 中野 ともみ, 植木 文, 野口 博人, 長谷川 江梨名, 山形 詩織, 大橋 和貴, 丸山 由華, 廣澤 宏, 鈴木 光幸, 深沢 尚子, 吉田 俊明, 日本消化器病学会雑誌, 113, 臨増大会, A754, A754, 2016年09月
(一財)日本消化器病学会, 日本語

レボカルニチン製剤投与中患者のSF-36を用いたQOL評価の検討　　　　　　　　　　　　　　　
植木 文, 石川 達, 阿部 聡司, 大橋 和貴, 阿部 弘子, 中野 ともみ, 小山 富士子, 長谷川 江梨名, 野口 博人, 山形 詩織, 小林 美樹, 渡邊 貴之, 吉田 俊明, 日本消化器病学会雑誌, 113, 臨増大会, A754, A754, 2016年09月
(一財)日本消化器病学会, 日本語

慢性肝疾患患者におけるChronic liver disease questionnaires(CLDQ)と包括的QOL評価であるSF-36の相関性の検討　　　　　　　　　　　　　　　
野口 博人, 石川 達, 阿部 弘子, 小山 富士子, 中野 ともみ, 植木 文, 小林 美樹, 長谷川 江梨名, 山形 詩織, 大橋 和貴, 丸山 由華, 廣澤 宏, 鈴木 光幸, 深沢 尚子, 吉田 俊明, 日本消化器病学会雑誌, 113, 臨増大会, A755, A755, 2016年09月
(一財)日本消化器病学会, 日本語

慢性肝疾患に対する肝外合併症であるそう痒感の実態調査　　　　　　　　　　　　　　　
山形 詩織, 石川 達, 阿部 聡司, 阿部 弘子, 小山 富士子, 中野 ともみ, 植木 文, 野口 博人, 小林 美樹, 長谷川 江梨名, 大橋 和貴, 丸山 由華, 廣澤 宏, 鈴木 光幸, 深澤 尚子, 吉田 俊明, 日本消化器病学会雑誌, 113, 臨増大会, A755, A755, 2016年09月
(一財)日本消化器病学会, 日本語

レボカルニチン製剤投与中患者のSF‐36を用いたQOL評価の検討
植木文, 石川達, 阿部聡司, 大橋和貴, 阿部弘子, 中野ともみ, 小山富士子, 長谷川江梨名, 野口博人, 山形詩織, 小林美樹, 渡邊貴之, 吉田俊明, 日本消化器病学会大会(Web), 58th, ROMBUNNO.SHOP‐404 (WEB ONLY), 2016年
日本語

慢性肝疾患に対する肝外合併症である掻痒感の実態調査
山形詩織, 石川達, 阿部聡司, 阿部弘子, 小山富士子, 中野ともみ, 植木文, 野口博人, 小林美樹, 長谷川江梨名, 大橋和貴, 丸山由華, 廣澤宏, 鈴木光幸, 深澤尚子, 吉田俊明, 日本消化器病学会大会(Web), 58th, ROMBUNNO.SHOP‐406 (WEB ONLY), 2016年
日本語

Daclatasvir/Asunaprevir療法におけるSF‐36を用いたQOL評価の検討
大橋和貴, 石川達, 阿部聡司, 阿部弘子, 阿部弘子, 中野ともみ, 植木文, 小山富士子, 長谷川江梨名, 野口博人, 山形詩織, 小林美樹, 渡邊貴之, 吉田俊明, 日本消化器病学会大会(Web), 58th, ROMBUNNO.SHOP‐341 (WEB ONLY), 2016年
日本語

Simeprevir3剤併用療法においてSF‐36によるQOL評価からIFN‐βに切り替え治療を完遂した2症例
大橋和貴, 新潟医学会雑誌, 129, 10, 617, 617, 2015年10月10日
新潟医学会, 日本語

C型肝炎患者に対するメディカルスタッフを中心とした肝臓病教室の臨床的意義
山形詩織, 石川達, 阿部弘子, 小山富士子, 中野ともみ, 植木文, 野口博人, 長谷川江梨名, 小林美樹, 大橋和貴, 廣澤宏, 丸山由華, 鈴木光幸, 深澤尚子, 吉田俊明, 肝臓, 56, Supplement 2, A789, 2015年09月10日
日本語

肝臓病教室参加者に対するSF‐36によるQOL改善効果の検討
野口博人, 石川達, 阿部弘子, 小山富士子, 中野ともみ, 植木文, 長谷川江梨名, 小林美樹, 山形詩織, 大橋和貴, 丸山由華, 廣澤宏, 鈴木光幸, 深澤尚子, 吉田俊明, 肝臓, 56, Supplement 2, A789, 2015年09月10日
日本語

C型肝炎治療クリニカルパス一元化による多様性への対応
岩野知子, 石川達, 山形詩織, 小林美樹, 大橋和貴, 金田藍子, 羽田千代子, 佐久間愛, 阿部聡司, 吉田俊明, 日本消化器病学会大会(Web), 57th, 臨増大会, SHOP‐332 (WEB ONLY), A904, 2015年09月
(一財)日本消化器病学会, 日本語

2021年09月 - 現在
日本医療情報学会　　　　　　　　　　　　　　　

2020年04月 - 現在
日本肝臓学会　　　　　　　　　　　　　　　

2018年04月 - 現在
日本医療マネジメント学会　　　　　　　　　　　　　　　

GISを用いた訪問看護のアクセシビリティの将来推計と可視化
科学研究費助成事業 基盤研究(C)
2022年04月01日 - 2025年03月31日
大橋 和貴
日本学術振興会, 基盤研究(C), 札幌保健医療大学, 22K11212

慢性肝疾患における身体活動によるサルコペニア予防に関する研究
科学研究助成費事業 研究活動スタート支援
2019年09月 - 2021年03月
大橋 和貴
文部科学省, 研究代表者, 競争的資金