Papers

• The role of the stapled interlobar fissure position for intraoperative detection and postoperative diagnosis of middle lobe torsion after right upper lobectomy.
  Kazuto Ohtaka, Setsuyuki Ohtake, Aki Fujiwara-Kuroda, Sho Narita, Shinya Otsuka, Hiroshi Yamasaki, Akihiro Sasaki, Haruhiko Shiiya, Hideki Ujiie, Masato Aragaki, Tatsuya Kato
  Journal of thoracic disease, 17, 3, 1268, 1277, 31 Mar. 2025, [International Magazine]
  English, Scientific journal, BACKGROUND: Lung torsion is caused by the lung twisting around the hilum, leading to severe conditions with a high mortality rate. We evaluated the usefulness of the stapled interlobar fissure (SIF) position for intraoperative detection and postoperative early diagnosis of middle lobe (ML) torsion after right upper lobectomy (RUL). METHODS: This retrospective study included 271 patients who underwent RUL at the Hokkaido University Hospital or Obihiro Kosei General Hospital. We assessed the SIF position between the upper lobe and ML on postoperative computed tomography (CT) scans and surgical videos, and correlated it with postoperative abnormalities in the ML, such as atelectasis or rotation of the bronchus and pulmonary vessels. RESULTS: On postoperative CT scans, the SIF position was on the interlobar side in 24 (96.0%) of 25 patients with abnormal findings in the ML, and on the mediastinal side in 224 (91.1%) of 246 patients without abnormalities (P<0.001). The sensitivity and specificity were 96.0% and 91.1%, respectively. At the end of the surgery, the SIF position was on the interlobar side in 10 (90.9%) of 11 patients with abnormal findings in the ML, and on the mediastinal side in 53 (86.9%) of 61 patients without abnormalities (P<0.001). The sensitivity and specificity were 90.9% and 86.9%, respectively. CONCLUSIONS: The SIF position observed at the end of the surgery and on postoperative CT scans was significantly associated with postoperative ML abnormalities. Therefore, observing SIF positions intraoperatively and on postoperative CT may aid in intraoperative detection and postoperative diagnosis of ML torsion after RUL.
• Outcomes of Surgical Lung Biopsy in Pleuroparenchymal Fibroelastosis: A Single-center Retrospective Study.
  Haruhiko Shiiya, Tomohiko Nakamura, Hideki Ujiie, Kazuto Ohtaka, Aki Fujiwara-Kuroda, Masato Aragaki, Kazufumi Okada, Tatsuya Kato
  Archivos de bronconeumologia, 29 Nov. 2024, [International Magazine]
  English, Scientific journal
• 肺虚血再灌流傷害におけるエリスロポエチンアナログ製剤の効果　　　　　　　　　　　　　　　
  椎谷 洋彦, 渡辺 正明, 千葉 龍平, 佐々木 明洋, 大高 和人, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加藤 達哉
  移植, 59, 総会臨時, 375, 375, (一社)日本移植学会, Sep. 2024
  Japanese
• 肺虚血再灌流傷害におけるエリスロポエチンアナログ製剤の効果　　　　　　　　　　　　　　　
  椎谷 洋彦, 渡辺 正明, 千葉 龍平, 佐々木 明洋, 大高 和人, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加藤 達哉
  移植, 59, 総会臨時, 375, 375, (一社)日本移植学会, Sep. 2024
  Japanese
• 先天性嚢胞性肺疾患に対するReduced port VATSの取り組み　　　　　　　　　　　　　　　
  藤原 晶, 高桑 佑佳, 佐々木 明洋, 椎谷 洋彦, 大高 和人, 氏家 秀樹, 新垣 雅人, 本多 昌平, 川原 仁守, 加藤 達哉
  日本気胸・嚢胞性肺疾患学会雑誌, 24, 2, 86, 86, 日本気胸・嚢胞性肺疾患学会, Aug. 2024
  Japanese
• 先天性嚢胞性肺疾患に対するReduced port VATSの取り組み　　　　　　　　　　　　　　　
  藤原 晶, 高桑 佑佳, 佐々木 明洋, 椎谷 洋彦, 大高 和人, 氏家 秀樹, 新垣 雅人, 本多 昌平, 川原 仁守, 加藤 達哉
  日本気胸・嚢胞性肺疾患学会雑誌, 24, 2, 86, 86, 日本気胸・嚢胞性肺疾患学会, Aug. 2024
  Japanese
• 肺移植クラウドファンディングを経験して
  加藤 達哉, 大塚 将平, 佐々木 明洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 氏家 秀樹, 新垣 雅人
  移植, 59, 1, 101, 101, (一社)日本移植学会, Jul. 2024
  Japanese
• ラット虚血再灌流傷害モデルを用いた新規抗炎症薬による肺傷害抑制効果の検討　　　　　　　　　　　　　　　
  椎谷 洋彦, 千葉 龍平, 渡辺 正明, 大塚 将平, 佐々木 明洋, 大高 和人, 氏家 秀樹, 藤原 晶, 新垣 雅人, 加藤 達哉
  移植, 59, 1, 88, 88, (一社)日本移植学会, Jul. 2024
  Japanese
• 肺移植クラウドファンディングを経験して　　　　　　　　　　　　　　　
  加藤 達哉, 大塚 将平, 佐々木 明洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 氏家 秀樹, 新垣 雅人
  移植, 59, 1, 101, 101, (一社)日本移植学会, Jul. 2024
  Japanese
• Epithelioid pleural mesothelioma successfully treated with perioperative immunotherapy: a case report.
  Gaku Yamazaki, Aki Fujiwara-Kuroda, Jun Muto, Hideki Ujiie, Masato Aragaki, Megumi Furuta, Sakurako Ohno, Kanako C Hatanaka, Yutaka Hatanaka, Yoshihiro Matsuno, Tatsuya Kato
  General Thoracic and Cardiovascular Surgery Cases, 3, 1, 31, 31, 11 Jun. 2024, [International Magazine]
  English, Scientific journal, BACKGROUND: Pleural mesothelioma, characterized by a dismal prognosis even with multimodal therapy, has seen emerging interest in immune checkpoint inhibitors (ICIs) due to their demonstrated efficacy. Here, we present a case of epithelioid-type pleural mesothelioma with chest wall invasion treated with definitive ICI therapy, resulting in a remarkable pretreatment effect. CASE PRESENTATION: A 46-year-old man was diagnosed with an abnormal chest shadow on a medical check, and a computed tomography scan showed pleural thickening at the dorsal right upper chest wall. One of the nodules was suspected to have invaded the chest wall. A needle biopsy revealed epithelioid-type pleural mesothelioma. After five cycles of nivolumab plus ipilimumab, he underwent right pleurectomy/decortication (P/D). Pathological examination revealed a significant treatment effect, showing numerous lymphocytes infiltrating the tumor nodule and viable tumor cells localized at approximately 6 mm. CONCLUSION: Although further accumulation of cases is required to evaluate the effectiveness and case selection, P/D after immunotherapy is a useful curative treatment option for advanced pleural mesothelioma.
• Impact of pulmonary vein-first ligation during lobectomy on the postoperative survival and recurrence rates in patients with non-small cell lung cancer: a multicenter propensity score-matched study.
  Haruhiko Shiiya, Hideki Ujiie, Ryohei Chiba, Shunsuke Nomura, Kazuto Ohtaka, Aki Fujiwara-Kuroda, Masato Aragaki, Keita Takahashi, Kazufumi Okada, Tatsuya Kato
  Surgery today, 30 May 2024, [Domestic magazines]
  English, Scientific journal, PURPOSE: Surgical manipulation of the lungs increases the number of circulating tumor cells and the subsequent risk of metastasis in patients with lung cancer. This study investigated whether or not ligating the tumor-draining pulmonary vein first during lobectomy could improve the prognosis of these patients. METHODS: We retrospectively evaluated patients who underwent curative lobectomy for solitary nonsmall-cell lung carcinoma between January 2012 and December 2016. We divided the patients into the vein-first group, in which all associated pulmonary veins were dissected and severed before cutting the pulmonary artery, bronchus, or pulmonary fissure, and the other procedure group. RESULTS: Overall, we included 177 and 413 patients in the vein-first and other procedure groups, respectively. Propensity score matching yielded 67 pairs of patients. The 5-year overall survival (85.6% [95% confidence interval, 77.3-94.8%] vs. 69.4% [58.7-81.9%], P = 0.03%) and recurrence-free survival (73.4% [63.3-85.1%] vs. 53.5% [42.5-67.3%], P = 0.02) were significantly better in the vein-first group than in the other procedure group. The cumulative recurrence rate at 5 years post-surgery was significantly lower in the vein-first group than in the other procedure group (21.7% vs. 38.3%, P = 0.04). CONCLUSION: Our study suggests that ligating the pulmonary vein first during lobectomy for lung cancer can improve the overall survival, recurrence-free survival, and cumulative recurrence rate.
• Dose Optimization of Intravenous Indocyanine Green for Malignant Lung Tumor Localization
  Hideki Ujiie, Ryohei Chiba, Akihiro Sasaki, Shunsuke Nomura, Haruhiko Shiiya, Shohei Otsuka, Hiroshi Yamasaki, Aki Fujiwara-Kuroda, Kazuto Ohtaka, Masato Aragaki, Kazufumi Okada, Yuma Ebihara, Tatsuya Kato
  Journal of Clinical Medicine, 13, 10, 2807, 2807, MDPI AG, 10 May 2024
  Scientific journal, Background: Intravenously administered indocyanine green (ICG) accumulates in lung tumors, facilitating their detection via a fluorescence spectrum measurement. This method aids in identifying tumor locations that are invisible to the naked eye. We aim to determine the optimal ICG dose and administration method for accurate tumor identification during lung resection surgeries, utilizing a novel ICG fluorescence spectroscopy system for precise tumor localization. Materials and Methods: ICG should be dissolved in the provided solution or distilled water and administered intravenously approximately 24 h before surgery, beginning with an initial dose of 0.5 mg/kg. If the tumor detection rate is insufficient, the dose may be gradually increased to a maximum of 5.0 mg/kg to determine the optimal dosage for effective tumor detection. This fluorescence spectroscopy during surgery may reveal additional lesions that remain undetected in preoperative assessments. The primary endpoint includes the correct diagnostic rate of tumor localization. The secondary endpoints include the measurement of the intraoperative ICG fluorescence spectral intensity in lung tumors, the assessment of the operability and safety of intraperitoneal ICG administrations, the measurement of the ICG fluorescence spectral intensity in surgical specimens, the comparison of the spectral intensity in lung tissues during collapse and expansion, the correlation between ICG camera images and fluorescence spectral intensity, and the comparison of fluorescence analysis results with histopathological findings. The trial has been registered in the jRCT Clinical Trials Registry under the code jRCTs011230037. Results and Conclusions: This trial aims to establish an effective methodology for localizing and diagnosing malignant lung tumors, thereby potentially improving surgical outcomes and refining treatment protocols.
• 低侵襲手術の未来像 Reduced port Robot-assisted thoracic surgery(RATS)の未来
  氏家 秀樹, 大塚 将平, 佐々木 明洋, 山崎 洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 新垣 雅人, 江花 弘基, 加藤 達哉
  気管支学, 46, Suppl., S171, S171, (一社)日本呼吸器内視鏡学会, May 2024
  Japanese
• 低侵襲手術の未来像 Reduced port Robot-assisted thoracic surgery(RATS)の未来
  氏家 秀樹, 大塚 将平, 佐々木 明洋, 山崎 洋, 椎谷 洋彦, 大高 和人, 藤原 晶, 新垣 雅人, 江花 弘基, 加藤 達哉
  気管支学, 46, Suppl., S171, S171, (一社)日本呼吸器内視鏡学会, May 2024
  Japanese
• A simple and safe surgical technique for nonpalpable lung tumors: One-stop Solution for a nonpalpable lung tumor, Marking, Resection, and Confirmation of the surgical margin in a Hybrid operating room (OS-MRCH)
  Aki Fujiwara-Kuroda, Masato Aragaki, Yasuhiro Hida, Hideki Ujiie, Kazuto Ohtaka, Haruhiko Shiiya, Kichizo Kaga, Tatsuya Kato
  Translational Lung Cancer Research, Mar. 2024
  Scientific journal
• Developing a Virtual Reality Simulation System for Preoperative Planning of Robotic-assisted Thoracic Surgery
  Aki Fujiwara-Kuroda
  Preprints.org, 21 Jan. 2024
  Scientific journal
• 薄壁空洞性病変を呈した原発性肺扁平上皮内癌の1例
  佐々木 明洋, 新垣 雅人, 竹野 巨樹, 山崎 洋, 野村 俊介, 大高 和人, 藤原 晶, 氏家 秀樹, 榊原 純, 大川 紘弥, 松野 吉宏, 加藤 達哉
  気管支学, 45, 6, 443, 443, (一社)日本呼吸器内視鏡学会, Nov. 2023
  Japanese
• 手術記録におけるメディカルイラストの利用　　　　　　　　　　　　　　　
  加賀 基知三, 藤原 晶, 新垣 雅人, 氏家 秀樹, 加藤 達哉
  日本臨床外科学会雑誌, 84, 増刊, S111, S111, 日本臨床外科学会, Oct. 2023
  Japanese
• Tumor-to-thoracic height ratio as an easy method to predict the feasibility of reduced-port video-assisted thoracic surgery for mediastinal lesions in children: a single-center experience.
  Haruhiko Shiiya, Kichizo Kaga, Hideki Ujiie, Aki Fujiwara-Kuroda, Jun Muto, Shunsuke Nomura, Shohei Honda, Tatsuya Kato
  Journal of thoracic disease, 15, 9, 5020, 5028, 28 Sep. 2023, [International Magazine]
  English, Scientific journal, In the last few decades, reduced-port video-assisted thoracic surgery (RP-VATS) has been developed to minimize surgical invasiveness. Nevertheless, VATS in children can occasionally be difficult because the lesion occupies a small thoracic cavity, limiting the working space. This study aimed to assess the feasibility of RP-VATS for the resection of mediastinal lesions in children in association with the tumor-to-thoracic height ratio (TTH ratio). We reviewed all patients aged ≤10 years who underwent resection for mediastinal lesions in our institute between January 2008 and August 2022. Patients who underwent diagnostic procedures were excluded from this study. The TTH ratio was calculated as tumor height divided by thoracic height. Seven patients in the RP-VATS group and six in the conventional procedures (multi-portal VATS or open surgery) group were included in this study. The TTH ratio was significantly lower in the RP-VATS group than in the conventional procedures group (median, 26.3% vs. 50.8%; P=0.007). The operating time (P=0.01) and duration of drainage (P=0.003) were significantly shorter and the blood loss (P=0.001) was significantly lower in the RP-VATS group than in the conventional procedures group. After adjusting for age, a lower TTH ratio was significantly associated with the completion of RP-VATS (odds ratio: 0.776; 95% confidence interval: 0.529-0.926; P=0.048). In conclusion, RP-VATS can be performed appropriately in carefully selected cases of pediatric mediastinal lesions. A low TTH ratio may predict the feasibility of RP-VATS. Further studies are warranted to determine the criteria for the indications of RP-VATS in children, so that more children can benefit from RP-VATS.
• Identification of micro-recurrent lesions using methylene blue for mediastinal ectopic parathyroid adenoma: a case report(タイトル和訳中)　　　　　　　　　　　　　　　
  Nomura Shunsuke, Ujiie Hideki, Fujiwara-Kuroda Aki, Kaga Kichizo, Aragaki Masato, Muto Jun, Chiba Ryohei, Yamazaki Gaku, Wakabayashi Kento, Matsuno Yoshihiro, Kato Tatsuya
  General Thoracic and Cardiovascular Surgery Cases, 2, 1 of 4, 4 of 4, BioMed Central, Aug. 2023
  English
• 肺胞出血を合併したLymphangioleiomyomatosisの1例　　　　　　　　　　　　　　　
  大高 和人, 竹野 巨樹, 山崎 洋, 佐々木 明洋, 野村 俊介, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加藤 達哉, 武井 望, 小熊 昂, 今野 哲, 大川 紘弥, 松野 吉宏
  日本気胸・嚢胞性肺疾患学会雑誌, 23, 2, 90, 90, 日本気胸・嚢胞性肺疾患学会, Aug. 2023
  Japanese
• 肺胞出血を合併したLymphangioleiomyomatosisの1例　　　　　　　　　　　　　　　
  大高 和人, 竹野 巨樹, 山崎 洋, 佐々木 明洋, 野村 俊介, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加藤 達哉, 武井 望, 小熊 昂, 今野 哲, 大川 紘弥, 松野 吉宏
  日本気胸・嚢胞性肺疾患学会雑誌, 23, 2, 90, 90, 日本気胸・嚢胞性肺疾患学会, Aug. 2023
  Japanese
• 気管支3Dモデルを用いた手術シミュレーション　　　　　　　　　　　　　　　
  藤原 晶, 山崎 雅久, 千葉 龍平, 野村 俊介, 武藤 潤, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 道田 共博, 若林 侑輝, 佐伯 和紀, 山口 仰, 加藤 達哉
  日本呼吸器外科学会雑誌, 37, 3, O39, 6, (一社)日本呼吸器外科学会, Jun. 2023
  Japanese
• 術後経時的ctDNA測定と腫瘍マーカーを併用した肺癌術後フォローアップ法は再発検出率を向上させる　　　　　　　　　　　　　　　
  加藤 達哉, Ming Chin Yoon, Low Siew-Kee, 清谷 一馬, 氏家 秀樹, 藤原 晶, 新垣 雅人, 中村 祐輔
  日本呼吸器外科学会雑誌, 37, 3, O52, 3, (一社)日本呼吸器外科学会, Jun. 2023
  Japanese
• 術前、術後免疫チェックポイント阻害薬および肺剥皮術による集学的治療を行ったびまん性胸膜中皮腫の1例　　　　　　　　　　　　　　　
  山崎 雅久, 藤原 晶, 千葉 龍平, 野村 俊介, 武藤 潤, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 古田 恵, 大野 桜子, 松野 吉宏, 加藤 達哉
  日本呼吸器外科学会雑誌, 37, 3, O59, 2, (一社)日本呼吸器外科学会, Jun. 2023
  Japanese
• 左上葉切除後の脳梗塞発症予防として肺静脈心嚢内処理を施行した症例の検討　　　　　　　　　　　　　　　
  武藤 潤, 山崎 雅久, 千葉 龍平, 野村 俊介, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 加藤 達哉
  日本呼吸器外科学会雑誌, 37, 3, O73, 5, (一社)日本呼吸器外科学会, Jun. 2023
  Japanese
• 巨大ダンベル型脊髄腫瘍に対する、後方アプローチおよびロボット支援下手術(RATS)　　　　　　　　　　　　　　　
  氏家 秀樹, 中谷 匠, 山崎 雅久, 野村 俊介, 千葉 龍平, 武藤 潤, 藤原 晶, 新垣 雅人, 加賀 基知三, 高畑 雅彦, 松野 吉宏, 加藤 達哉
  日本呼吸器外科学会雑誌, 37, 3, P42, 1, (一社)日本呼吸器外科学会, Jun. 2023
  Japanese
• 多発胸腺腫疑いに対し手術を施行し、胸腺癌と胸腺腫の同時多発が判明した1例　　　　　　　　　　　　　　　
  中谷 匠, 野村 俊介, 藤原 晶, 氏家 秀樹, 新垣 雅人, 加賀 基知三, 加藤 憲士郎, 松野 吉宏, 加藤 達哉
  日本呼吸器外科学会雑誌, 37, 3, P68, 7, (一社)日本呼吸器外科学会, Jun. 2023
  Japanese
• A novel edge-marking method in pleural covering with video-assisted thoracic surgery.
  Aki Fujiwara-Kuroda, Yasuhiro Hida, Hideki Ujiie, Kichizo Kaga, Tatsuya Kato
  Interdisciplinary cardiovascular and thoracic surgery, 36, 3, 02 Mar. 2023, [International Magazine]
  English, Scientific journal, Total pleural covering is implemented to reinforce the visceral pleura with surgical sheets. It has been adopted for diffuse cystic lung diseases such as lymphangioleiomyomatosis to prevent pneumothorax and has achieved good results. The procedure is technically demanding, because it is difficult to cover the entire visceral pleura without disarrangement and jamming of surgical sheets, especially during thoracoscopic surgery, where grasping of a wrong site might happen when unfolding the sheets. Herein, we report a technique to cover the entire pleura with dotted line folded sheets to ease the thoracoscopic procedure. We found that the use of this marking method made the procedure easier, with just a little ingenuity, because marking the edges of sheets with dashed lines clarifies the site that should be grasped, thus preventing the incidence of grasping the wrong part of the sheet. Pleural covering with dotted line folded surgical sheets is a useful method for reduced port thoracoscopic surgery.
• 医学生、研修医を対象とした医学教育とメディカルイラストの利用　　　　　　　　　　　　　　　
  加賀 基知三, 藤原 晶, 山崎 雅久, 千葉 龍平, 野村 俊介, 武藤 潤, 氏家 秀樹, 新垣 雅人, 加藤 達哉
  日本メディカルイラストレーション学会学術集会・総会, 7回, O, 3, 日本メディカルイラストレーション学会, Mar. 2023
  Japanese
• 腹臥位・人工気胸下での胸腔内剥離が有用であった巨大縦隔内甲状腺腫の1例　　　　　　　　　　　　　　　
  武藤 潤, 加納 里志, 山崎 雅久, 千葉 龍平, 野村 俊介, 藤原 晶, 氏家 秀樹, 樋田 泰浩, 加賀 基知三, 本間 明宏, 加藤 達哉
  日本臨床外科学会雑誌, 83, 12, 2119, 2119, 日本臨床外科学会, Dec. 2022
  Japanese
• 胸部単純エックス線写真読影の教材としてのデジタルイラスト
  加賀 基知三, 藤原 晶, 長島 諒太, 野村 俊介, 千葉 龍平, 田畑 佑希子, 氏家 秀樹, 加藤 達哉, 樋田 泰浩
  日本メディカルイラストレーション学会雑誌, 4, 1, 12, 12, 日本メディカルイラストレーション学会, Dec. 2022
  Japanese
• 胸部単純エックス線写真読影の教材としてのデジタルイラスト　　　　　　　　　　　　　　　
  加賀 基知三, 藤原 晶, 長島 諒太, 野村 俊介, 千葉 龍平, 田畑 佑希子, 氏家 秀樹, 加藤 達哉, 樋田 泰浩
  日本メディカルイラストレーション学会雑誌, 4, 1, 12, 12, 日本メディカルイラストレーション学会, Dec. 2022
  Japanese
• 胸・腹腔鏡併用下に横隔膜縫縮術を施行した食道癌術後横隔膜弛緩症の1例
  武藤 潤, 山崎 雅久, 千葉 龍平, 野村 俊介, 高島 雄太, 藤原 晶, 氏家 秀樹, 村上 壮一, 倉島 庸, 海老原 裕磨, 七戸 俊明, 樋田 泰浩, 加賀 基知三, 平野 聡, 加藤 達哉
  気管支学, 44, 6, 457, 457, (NPO)日本呼吸器内視鏡学会, Nov. 2022
  Japanese
• 胸・腹腔鏡併用下に横隔膜縫縮術を施行した食道癌術後横隔膜弛緩症の1例
  武藤 潤, 山崎 雅久, 千葉 龍平, 野村 俊介, 高島 雄太, 藤原 晶, 氏家 秀樹, 村上 壮一, 倉島 庸, 海老原 裕磨, 七戸 俊明, 樋田 泰浩, 加賀 基知三, 平野 聡, 加藤 達哉
  気管支学, 44, 6, 457, 457, (NPO)日本呼吸器内視鏡学会, Nov. 2022
  Japanese
• A case report of video-assisted flap bronchoplasty for central type typical carcinoid
  Yuya Wada, Hideki Ujiie, Ryohei Chiba, Shunsuke Nomura, Aki Fujiwara-Kuroda, Kichizo Kaga, Satoru Wakasa, Tatsuya Kato
  VIDEO-ASSISTED THORACIC SURGERY, Aug. 2022
  English, Scientific journal
• デジタルイラストで伝わる手術記録(オペレコ)を描こう　　　　　　　　　　　　　　　
  加賀 基知三, 藤原 晶, 山崎 雅久, 千葉 龍平, 野村 俊介, 武藤 潤, 氏家 秀樹, 樋田 泰浩, 加藤 達哉
  日本気胸・嚢胞性肺疾患学会雑誌, 22, 2, 94, 94, 日本気胸・嚢胞性肺疾患学会, Aug. 2022
  Japanese
• びまん性肺疾患を有する気胸に対しての治療戦略 骨髄移植後の移植片対宿主病(GVHD)肺病変を背景とした気胸手術症例の検討　　　　　　　　　　　　　　　
  武藤 潤, 山崎 雅久, 千葉 龍平, 野村 俊介, 藤原 晶, 氏家 秀樹, 樋田 泰浩, 加賀 基知三, 加藤 達哉
  日本気胸・嚢胞性肺疾患学会雑誌, 22, 2, 107, 107, 日本気胸・嚢胞性肺疾患学会, Aug. 2022
  Japanese
• A novel system for analyzing indocyanine green (ICG) fluorescence spectra enables deeper lung tumor localization during thoracoscopic surgery.
  Ryohei Chiba, Yuma Ebihara, Haruhiko Shiiya, Hideki Ujiie, Aki Fujiwara-Kuroda, Kichizo Kaga, Liming Li, Satoru Wakasa, Satoshi Hirano, Tatsuya Kato
  Journal of thoracic disease, 14, 8, 2943, 2952, Aug. 2022, [International Magazine]
  English, Scientific journal, Background: Palpation of tumors during thoracoscopic surgery remains difficult, and identification of deep-seated tumors may be impossible. This preclinical study investigated the usefulness of a novel indocyanine green (ICG) fluorescence spectroscopy system for tumor localization. Methods: ICG was diluted to 5.0×10-2 mg/mL in fetal bovine serum (FBS) and mixed with silicone resin to prepare pseudo-tumors. Sponges of different densities and a porcine lung were placed on top of the pseudo-tumors, which were examined using a novel fluorescence spectroscopy system and a near-infrared (NIR) camera. Spectra were measured for different sponge and lung thicknesses, and the lung spectra were measured during both inflation and deflation. Results: The fluorescence spectroscopy system was able to identify tumors at depths ≥15 mm, while the NIR system was not. The spectroscopy system also detected tumors at greater depths when the density of the intervening material was lower. Depending on the density and thickness of the intervening material, the system could detect spectra as deep as 40 mm for sponges and 30 mm for lungs. Conclusions: This new fluorescence spectroscopy system can be used to identify lung tumors up to a depth of 30 mm in experiments using pseudo-tumors and a porcine lung, which may aid in tumor identification during thoracoscopic surgery.
• 気管支充填術および持続陰圧吸引療法が有効であった有瘻性膿胸の一例
  山崎 雅久, 氏家 秀樹, 野村 俊介, 千葉 龍平, 武藤 潤, 藤原 晶, 樋田 泰浩, 加賀 基知三, 三浦 瞬, 高島 雄太, 品川 尚文, 加藤 達哉
  小切開・鏡視外科学会雑誌, 13, 1, 58, 58, (NPO)小切開・鏡視外科学会, Jun. 2022
  Japanese
• 気管支充填術および持続陰圧吸引療法が有効であった有瘻性膿胸の一例
  山崎 雅久, 氏家 秀樹, 野村 俊介, 千葉 龍平, 武藤 潤, 藤原 晶, 樋田 泰浩, 加賀 基知三, 三浦 瞬, 高島 雄太, 品川 尚文, 加藤 達哉
  小切開・鏡視外科学会雑誌, 13, 1, 58, 58, (NPO)小切開・鏡視外科学会, Jun. 2022
  Japanese
• da Vinciステープラー挿入困難であったロボット支援下肺切除術導入初期の1手術例　　　　　　　　　　　　　　　
  林 諭史, 川田 将也, 藤原 晶, 氏家 秀樹
  日本呼吸器外科学会雑誌, 36, Suppl., O97, 3, (一社)日本呼吸器外科学会, May 2022
  Japanese
• Presurgical assessment of flow variability in an azygos vein aneurysm using 4D-flow MRI.
  Takuya Ikushima, Hideki Ujiie, Satonori Tsuneta, Ryohei Chiba, Yukiko Tabata, Aki Fujiwara-Kuroda, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Tatsuya Kato
  General thoracic and cardiovascular surgery, 70, 7, 673, 676, 06 Apr. 2022, [Domestic magazines]
  English, Scientific journal, Azygos vein aneurysm (AVA) is necessary to prevent pulmonary embolism due to the outflow of a thrombus or rupture of the aneurysm. However, there is no established modality to assess the properties of AVA. Time-resolved three-dimensional phase-contrast magnetic resonance imaging (4D-flow MRI) has been used to examine the hemodynamics in various fields. We report a case of AVA to evaluate the flow variability and adhesions of surrounding tissues using 4D-flow MRI. The findings of the study suggested aneurysm turbulence and the absence of thrombi. The cine image, which showed a sliding wall synchronized to the heartbeat, indicated no adhesion to the superior vena cava. Based on these results, the thoracoscopic approach was deemed possible preoperatively. Thoracoscopic AVA resection was performed, and the postoperative course was uneventful. This study documented the utility of 4D-flow MRI for a detailed evaluation of AVA.
• 新規胸腔鏡用蛍光スペクトル測定システムは深部肺腫瘍の同定を可能にする　　　　　　　　　　　　　　　
  千葉 龍平, 加藤 達哉, 海老原 裕磨, 氏家 秀樹, 田畑 佑希子, 藤原 晶, 樋田 泰浩, 加賀 基知三
  日本外科学会定期学術集会抄録集, 122回, SF, 5, (一社)日本外科学会, Apr. 2022
  Japanese
• 3D-バーチャル・リアリティー(VR)システムを用いた、呼吸器外科ロボット手術トレーニング法の開発　　　　　　　　　　　　　　　
  氏家 秀樹, 幾島 拓也, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲
  日本外科学会定期学術集会抄録集, 122回, SF, 3, (一社)日本外科学会, Apr. 2022
  Japanese
• 胸部単純エックス線写真読影の教材としてのデジタルイラスト　　　　　　　　　　　　　　　
  加賀 基知三, 藤原 晶, 長島 諒太, 野村 俊介, 千葉 龍平, 田畑 佑希子, 氏家 秀樹, 加藤 達哉, 樋田 泰浩
  日本メディカルイラストレーション学会学術集会・総会, 6回, np20, np21, 日本メディカルイラストレーション学会, Mar. 2022
  Japanese
• Cadaverを用いた高難度呼吸器外科手術手技トレーニングの取り組み　　　　　　　　　　　　　　　
  藤原 晶, 加藤 達哉, 幾島 拓也, 千葉 龍平, 田畑 佑希子, 氏家 秀樹, 樋田 泰浩, 加賀 基知三
  日本臨床外科学会雑誌, 83, 3, 598, 598, 日本臨床外科学会, Mar. 2022
  Japanese
• Successful Treatment for a Large Chronic Expanding Hematoma Treated by Pneumonectomy after Arterial Embolization
  Aki Fujiwara-Kuroda, Nozomu Iwashiro, Masanori Ohara, Kichizo Kaga
  Case Reports in Pulmonology, 2022, 1, 5, Hindawi Limited, 18 Feb. 2022, [Peer-reviewed], [Lead author]
  Scientific journal
• 切除を先行した巨大(>10cm)肺腫瘤の2症例　　　　　　　　　　　　　　　
  千葉 龍平, 加賀 基知三, 幾島 拓也, 田畑 佑希子, 藤原 晶, 氏家 秀樹, 加藤 達哉, 樋田 泰浩, 若狭 哲, 岡崎 ななせ, 若林 健人, 松野 吉宏
  肺癌, 62, 1, 72, 73, (NPO)日本肺癌学会, Feb. 2022
  Japanese
• Intralobar pulmonary sequestration associated with left main coronary artery obstruction and mitral regurgitation.
  Yusuke Motohashi, Tatsuya Kato, Nobuyasu Kato, Masato Aragaki, Aki Fujiwara-Kuroda, Tsuyoshi Tachibana, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa
  General thoracic and cardiovascular surgery, 69, 12, 1575, 1579, Dec. 2021, [Domestic magazines]
  English, Scientific journal, A 4-year-old boy with left intralobar pulmonary sequestration associated with left main coronary artery obstruction (LMCAO) and severe mitral regurgitation (MR) was admitted to our hospital. Since the patient presented with dyskinesia of the cardiac apex and increased left ventricular end-diastolic volume (LVEDV), left main coronary artery reconstruction and mitral annuloplasty were performed. The enlargement of the left ventricle was improved after sequential surgeries. There was a risk of deterioration of MR and regrowth of LVEDV due to shunt blood flow; therefore, left lower lobectomy and aberrant artery division were performed. This is a very rare case of a patient with pulmonary sequestration associated with LMCAO and severe MR.
• Surgical treatment for tracheal stent prolapse in a patient with blunt tracheal trauma.
  Shinya Otsuka, Tatsuya Kato, Hideki Ujiie, Aki Fujiwara-Kuroda, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Yuta Takashima, Naofumi Shinagawa
  General thoracic and cardiovascular surgery, 69, 12, 1589, 1592, Dec. 2021, [Domestic magazines]
  English, Scientific journal, Blunt tracheal injury is a rare but life-threatening condition. Several indications for treatment have been reported. Conservative treatment (i.e., stenting) can be performed when the patient is clinically stable or has medical contraindications to surgical treatment. Although some studies have reported the use of tracheal stents as treatment for iatrogenic injury and blunt trauma, the efficacy of these stents is unknown. Herein, we report a case of emergency tracheoplasty for the management of tracheal stent prolapse in a patient with blunt tracheobronchial trauma. This report highlights the necessity of being cautious about the migration and prolapse of tracheal stents, which can more frequently occur in blunt trauma than in malignant stenosis or iatrogenic injury. Due to the limitations of non-surgical treatments, early surgical intervention may be lifesaving.
• ECMO運用に関わる院内ガイドラインの作成　　　　　　　　　　　　　　　
  藤原 晶, 若狭 哲, 大岡 智学, 斉藤 仁志, 新宮 康栄, 加賀 基知三, 太田 稔, 南須原 康行
  日本胸部外科学会定期学術集会, 74回, OD1, 1, (一社)日本胸部外科学会, Oct. 2021
  Japanese
• 未来のための今 胸部外科医育成のための新たなる挑戦 3D-バーチャル・リアリティー(VR)システムを用いた、呼吸器外科手術トレーニング法の開発　　　　　　　　　　　　　　　
  氏家 秀樹, 幾島 拓也, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲
  日本胸部外科学会定期学術集会, 74回, SP5, 3, (一社)日本胸部外科学会, Oct. 2021
  Japanese
• 奇静脈瘤の伸展評価における4D-Flow MRIの有用性　　　　　　　　　　　　　　　
  幾島 拓也, 氏家 秀樹, 加藤 達哉, 大塚 慎也, 千葉 龍平, 野村 俊介, 椎谷 洋彦, 田畑 佑希子, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲
  日本胸部外科学会定期学術集会, 74回, LOD19, 5, (一社)日本胸部外科学会, Oct. 2021
  Japanese
• Rare Diagnosis of a Multilobular Pulmonary Mass.
  Yoshinobu Watabe, Hideki Ujiie, Yoshihiro Matsuno, Hideaki Fukui, Aki Fujiwara-Kuroda, Tatsuya Kato, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa
  Chest, 160, 1, e63-e67, Jul. 2021, [International Magazine]
  English, Scientific journal, CASE PRESENTATION: A 57-year-old woman was admitted to our hospital for an abnormal chest shadow found during routine chest radiography. She had no respiratory symptoms. Her medical history included dyslipidemia, and her surgical history included conization for cervical cancer at age 38 years. She was a social drinker and ex-smoker of approximately 10 cigarettes per day (from ages 20 to 30 years); she denied recreational drug use.
• バーチャル・リアリティー(VR)システムを用いた、呼吸器外科手術シミュレーション法の開発
  氏家 秀樹, 大塚 慎也, 千葉 龍平, 椎谷 洋彦, 藤原 晶, 加藤 達哉, 樋田 泰浩, 加賀 基知三, 若狭 哲
  気管支学, 43, Suppl., S241, S241, (NPO)日本呼吸器内視鏡学会, Jun. 2021
  Japanese
• Feasibility of limited resection for peripheral small-sized non-small cell lung cancer: a retrospective single-center-based study.
  Masato Aragaki, Yasuhiro Hida, Tatsuya Kato, Aki Fujiwara-Kuroda, Kichizo Kaga, Satoru Wakasa
  Journal of cancer research and clinical oncology, 147, 5, 1519, 1527, May 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, PURPOSE: This study aimed to establish new criteria for limited resection of non-small cell lung cancer (NSCLC) based on computed tomography findings and maximum standardized uptake value (SUVmax). METHODS: Between December 2007 and December 2015, 611 patients underwent lung cancer surgery; of these, 70 with cT1aN0M0 who underwent limited resection were enrolled. Criteria for undergoing intentional limited resection (ILR) were (1) tumor ground-glass opacity (GGO) ratio of ≥ 0.75 and (2) tumor SUVmax ≤ 1.5. Patients who met criteria (1) and (2) underwent partial resection, and those who only met criteria (2) underwent segmentectomy as ILR. The control group was subjected to limited surgery without meeting the criteria. RESULTS: Overall, 45 and 25 patients who met the criteria were included in the ILR and control groups, respectively. In the ILR group, 13 patients underwent partial resection, and 32 underwent segmentectomy; in the control group, 18 patients underwent partial resection and 7 underwent segmentectomy. According to our criteria, no relapsed cases occurred in the ILR group, although six patients showed recurrence of lung cancer in the control group. The 5-year overall survival (OS) rates in the ILR and control groups were 100% and 67.7%, respectively, and the relapse-free survival (RFS) rates were 100% and 61.6%, respectively. The log-rank test showed that this difference was statistically significant (OS: P < 0.0001, RFS: P < 0.0001). CONCLUSIONS: SUVmax may serve as a predictive marker of recurrence to determine the treatment strategy for patients with NSCLC. Patients with low GGO ratio and low SUVmax may be cured by limited resection.
• Pneumatosis Intestinalis After Living Donor Lung Transplantation Associated With Alpha-Glucosidase Inhibitor Treatment: A Case Report.
  Shinya Otsuka, Hideki Ujiie, Tatsuya Kato, Haruhiko Shiiya, Aki Fujiwara-Kuroda, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa, Rei Inoue, Yasuaki Iimura
  Transplantation proceedings, 53, 4, 1379, 1381, May 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• 血気胸を発症したPleuroparenchymal fibroelastosis(PPFE)合併肺癌の1切除例
  大塚 慎也, 加藤 達哉, 佐々木 明洋, 山崎 洋, 氏家 秀樹, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 中村 順一, 篠崎 鮎香, 中久保 祥, 木村 孔一, 渡辺 正明, 岡崎 ななせ, 松野 吉宏
  肺癌, 61, 1, 67, 67, (NPO)日本肺癌学会, Feb. 2021
  Japanese
• 神経線維腫症I型に肺腺癌、内頸動静脈瘻を合併した1例
  横山 誓也, 氏家 秀樹, 加藤 達哉, 大塚 慎也, 佐々木 明洋, 山崎 洋, 藤原 晶, 樋田 泰浩, 加賀 基知三, 若狭 哲, 松野 吉宏, 今井 陽子
  肺癌, 61, 1, 67, 68, (NPO)日本肺癌学会, Feb. 2021
  Japanese
• Intraoperative real-time hemodynamics in intralobar pulmonary sequestration using indocyanine green and near-infrared thoracoscopy.
  Yusuke Motohashi, Tatsuya Kato, Masato Aragaki, Aki Fujiwara-Kuroda, Yasuhiro Hida, Satoru Wakasa, Kichizo Kaga
  General thoracic and cardiovascular surgery, 69, 2, 383, 387, Feb. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, A 33-year-old man with left pulmonary sequestration was admitted to our hospital. We planned left basilar segmentectomy to preserve the lung function, using indocyanine green (ICG) and near-infrared thoracoscopy. The intravenous (IV) administration of ICG (0.1 mg/kg) showed the distribution of fluorescence from the aberrant arteries, blood flow blockage from the aberrant arteries after they were divided, and the superior-basal boundary after the pulmonary artery and vein were divided. In adult patients with intralobar pulmonary sequestration, ICG and near-infrared thoracoscopic techniques are useful to confirm abnormal hemodynamics and demonstrate a safe and successful basilar segmentectomy.
• A case of resected pulmonary lymphomatoid granulomatosis
  Aki Fujiwara-Kuroda, Nozomu Iwashiro, Noriko Kimura
  Respiratory Medicine Case Reports, 32, 101327, 101327, Elsevier {BV}, 2021, [Peer-reviewed], [Lead author]
  English, Scientific journal
• A Novel Insertion Technique for the Extra-Long Montgomery T-Tube in Patients with a Large Mediastinal Tumor.
  Tatsuya Kato, Aki Fujiwara-Kuroda, Nobuyuki Shiina, Masato Aragaki, Hideki Ujiie, Yasuhiro Hida, Kichizo Kaga
  Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 26, 5, 294, 297, 21 Oct. 2020, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal
• 巨大縦隔腫瘍患者における超長尺Montgomery Tチューブの新規挿入法(A Novel Insertion Technique for the Extra-Long Montgomery T-Tube in Patients with a Large Mediastinal Tumor)
  Kato Tatsuya, Fujiwara-Kuroda Aki, Shiina Nobuyuki, Aragaki Masato, Ujiie Hideki, Hida Yasuhiro, Kaga Kichizo
  Annals of Thoracic and Cardiovascular Surgery, 26, 5, 294, 297, 「Annals of Thoracic and Cardiovascular Surgery」編集委員会, Oct. 2020
  English
• Preoperative identification of clinicopathological prognostic factors for relapse-free survival in clinical N1 non-small cell lung cancer: a retrospective single center-based study.
  Masato Aragaki, Tatsuya Kato, Aki Fujiwara-Kuroda, Yasuhiro Hida, Kichizo Kaga, Satoru Wakasa
  Journal of cardiothoracic surgery, 15, 1, 229, 229, 28 Aug. 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: Given the difficulty in preoperatively diagnosing lymph node metastasis, patients with Stage I-III non-small cell lung cancer (NSCLC) are likely to be included in the clinical N1 (cN1) group. However, better treatment options might be selected through further stratification. This study aimed to identify preoperative clinicopathological prognostic and stratification factors for patients with cN1 NSCLC. METHODS: This retrospective study evaluated 60 patients who were diagnosed with NSCLC during 2004-2014. Clinical nodal status had been evaluated using routine chest computed tomography (CT) and/or positron emission tomography (PET). To avoid biasing the fluorodeoxyglucose uptake values based on inter-institution or inter-model differences, we used only two PET systems (one PET system and one PET/CT system). Relapse-free survival (RFS) and overall survival (OS) were the primary study outcomes. The maximum standardized uptake value (SUVmax) was calculated for each tumor and categorized as low or high based on the median value. Patient sex, age, histology, tumor size, and tumor markers were also assessed. RESULTS: Poor OS was associated with older age (P = 0.0159) and high SUVmax values (P = 0.0142). Poor RFS was associated with positive carcinoembryonic antigen (CEA) expression (P = 0.0035) and high SUVmax values (P = 0.015). Multivariate analyses confirmed that poor OS was independently predicted by older age (hazard ratio [HR] = 2.751, confidence interval [CI]: 1.300-5.822; P = 0.0081) and high SUVmax values (HR = 5.121, 95% CI: 1.759-14.910; P = 0.0027). Furthermore, poor RFS was independently predicted by positive CEA expression (HR = 2.376, 95% CI: 1.056-5.348; P = 0.0366) and high SUVmax values (HR = 2.789, 95% CI: 1.042-7.458; P = 0.0410). The primary tumor's SUVmax value was also an independent prognostic factor for both OS and RFS. CONCLUSIONS: For patients with cN1 NSCLC, preoperative prognosis and stratification might be performed based on CEA expression, age, and the primary tumor's SUVmax value. To enhance the prognostic value of the primary tumor's SUVmax value, minimizing bias between facilities and models could lead to a more accurate prognostication.
• 出産を契機に生じた奇静脈瘤内血栓に対し緊急手術を施行した1例　　　　　　　　　　　　　　　
  椎名 伸行, 加藤 達哉, 佐々木 明洋, 山崎 洋, 藤原 晶, 氏家 秀樹, 樋田 泰浩, 福井 秀章, 松野 吉宏, 加賀 基知三
  日本呼吸器外科学会雑誌, 34, 3, MO64, 4, (NPO)日本呼吸器外科学会, Aug. 2020
  Japanese
• Adenocarcinoma arising from an ectopic pancreas in the duodenum: a case report.
  Tsukasa Kaneko, Masanori Ohara, Kunishige Okamura, Aki Fujiwara-Kuroda, Daisuke Miyasaka, Takumi Yamabuki, Ryo Takahashi, Kazuteru Komuro, Masato Suzuoki, Nozomu Iwashiro, Mototsugu Kato, Noriko Kimura, Hiroshi Kijima, Toru Nakamura, Satoshi Hirano
  Surgical case reports, 5, 1, 126, 126, 06 Aug. 2019, [International Magazine]
  English, Scientific journal, BACKGROUND: The malignant transformation of an ectopic pancreas in the duodenum is extremely rare. Herein, we report a case of an adenocarcinoma that arose from an ectopic pancreas. We also reviewed 14 cases of malignant transformations arising from an ectopic pancreas in the duodenum that were previously published. CASE PRESENTATION: An 81-year-old man with a 1-month history of vomiting was admitted to our institution. Esophagogastroduodenoscopy (EGD) and computed tomography (CT) scans revealed an obstruction at the first part of the duodenum. A distal gastrectomy was performed for diagnostic and therapeutic purposes. The histopathological examination of the resected specimen showed adenocarcinoma that arose from an ectopic pancreas (Heinrich type 1). The patient is alive without relapse at 18 months of follow-up. CONCLUSIONS: Adenocarcinoma that arises from an ectopic pancreas should be considered when an obstruction is identified in the duodenum.
• 不全分葉間に発生した肺癌に対する胸腔鏡下複合区域切除における赤外光胸腔鏡の有用性　　　　　　　　　　　　　　　
  加藤 達哉, 新垣 雅人, 藤原 晶, 本橋 雄介, 樋田 泰浩, 福井 秀章, 松野 吉宏, 加賀 基知三, 松居 喜郎
  日本呼吸器外科学会雑誌, 33, 3, P57, 2, (NPO)日本呼吸器外科学会, Apr. 2019, [Peer-reviewed]
  Japanese
• Prognostic value of MAGEA4 in primary lung cancer depends on subcellular localization and p53 status
  Aki Fujiwara-Kuroda, Tatsuya Kato, Takehiro Abiko, Takahiro Tsuchikawa, Noriaki Kyogoku, Masaomi Ichinokawa, Kimitaka Tanaka, Takehiro Noji, Yasuhiro Hida, Kichizo Kaga, Yoshiro Matsui, Hiroaki Ikeda, Shinichi Kageyama, Hiroshi Shiku, Satoshi Hirano
  International Journal of Oncology, 53, 2, 713, 724, Spandidos Publications, 31 May 2018, [Peer-reviewed], [Lead author]
  Scientific journal