2020, NIH Fellows Award for Research Excellence (FARE)　　　　　　　　　　　　　　　

Nov. 2014, 日本臨床ストレス応答学会, 若手研究奨励賞　　　　　　　　　　　　　　　
田中 努

Amplified Type I Interferon Response in Sjögren's Disease via Ectopic Toll‐Like Receptor 7 Expression in Salivary Gland Epithelial Cells Induced by Lysosome‐Associated Membrane Protein 3
Hiroyuki Nakamura, Tsutomu Tanaka, Changyu Zheng, Sandra A. Afione, Tatsuya Atsumi, Masayuki Noguchi, Fabiola Reis Oliveira, Ana Carolina F. Motta, Fernando Chahud, Eduardo M. Rocha, Blake M. Warner, John A. Chiorini
Arthritis & Rheumatology, Jul. 2024
Scientific journal

The balance between nuclear import and export of NLRC5 regulates MHC class I transactivation
Baohui Zhu, Ryota Ouda, Ning An, Tsutomu Tanaka, Koichi S. Kobayashi
Journal of Biological Chemistry, May 2024
Scientific journal

LAMP3 induces lysosome‐dependent cell death by impairing autophagic caspase‐8 degradation in Sjögren's salivary glands
Hiroyuki Nakamura, Tsutomu Tanaka, Changyu Zheng, Sandra A Afione, Blake M. Warner, Masayuki Noguchi, Tatsuya Atsumi, John A. Chiorini
Arthritis & Rheumatology, 25 Apr. 2023, [Lead author]
Scientific journal

Salivary gland LAMP3 mRNA expression is a possible predictive marker in the response to hydroxychloroquine in Sjögren’s disease
Hiroyuki Nakamura, Tsutomu Tanaka, Youngmi Ji, Changyu Zheng, Sandra A. Afione, Blake M. Warner, Fabiola Reis Oliveira, Ana Carolina F. Motta, Eduardo M. Rocha, Masayuki Noguchi, Tatsuya Atsumi, John A. Chiorini
PLOS ONE, 18, 2, Public Library of Science ({PLoS}), 23 Feb. 2023, [Lead author]
English, Scientific journal, Hydroxychloroquine (HCQ) is a lysosomotropic agent that is commonly used for treating Sjögren’s disease (SjD). However, its efficacy is controversial because of the divergent response to the drug among patients. In a subgroup of SjD patients, lysosome-associated membrane protein 3 (LAMP3) is elevated in expression in the salivary glands and promotes lysosomal dysregulation and lysosome-dependent apoptotic cell death. In this study, chloroquine (CQ) and its derivative HCQ were tested for their ability to prevent LAMP3-induced apoptosis, in vitro and on a mouse model of SjD. In addition, efficacy of HCQ treatment was retrospectively compared between high LAMP3 mRNA expression in minor salivary glands and those with LAMP3 mRNA levels comparable with healthy controls. Study results show that CQ treatment stabilized the lysosomal membrane in LAMP3-overexpressing cells via deactivation of cathepsin B, resulting in decreased apoptotic cell death. In mice with established SjD-like phenotype, HCQ treatment also significantly decreased apoptotic cell death and ameliorated salivary gland hypofunction. Retrospective analysis of SjD patients found that HCQ tended to be more effective in improving disease activity index, symptom severity and hypergammaglobulinemia in patients with high LAMP3 expression compared those with normal LAMP3 expression. Taken together, these findings suggested that by determining salivary gland LAMP3 mRNA level, a patient’s response to HCQ treatment could be predicted. This finding may provide a novel strategy for guiding the development of more personalized medicine for SjD.

LAMP3 transfer via extracellular particles induces apoptosis in Sjögren’s disease
Tsutomu Tanaka, Hiroyuki Nakamura, Duy T. Tran, Blake M. Warner, Yan Wang, Tatsuya Atsumi, Masayuki Noguchi, John A. Chiorini
Scientific Reports, 13, 1, Springer Science and Business Media {LLC}, 14 Feb. 2023, [Lead author]
English, Scientific journal, AbstractSjögren’s disease (SjD) is an autoimmune disease that affects exocrine tissues and is characterized by increased apoptosis in salivary and lacrimal glands. Although the pathogenic mechanism triggering SjD is not well understood, overexpression of lysosome-associated membrane protein 3 (LAMP3) is associated with the disease in a subset of SjD patients and the development of SjD-like phenotype in mice. In this study, histological analysis of minor salivary glands of SjD patients suggested that LAMP3-containing material is being ejected from cells. Follow-on in vitro experiments with cells exposed to extracellular particles (EPs) derived from LAMP3-overexpressing cells showed increased apoptosis. Proteomics identified LAMP3 as a major component of EPs derived from LAMP3-overexpressing cells. Live-cell imaging visualized release and uptake of LAMP3-containing EPs from LAMP3-overexpressing cells to naïve cells. Furthermore, experiments with recombinant LAMP3 protein alone or complexed with Xfect protein transfection reagent demonstrated that internalization of LAMP3 was required for apoptosis in a caspase-dependent pathway. Taken together, we identified a new role for extracellular LAMP3 in cell-to-cell communication via EPs, which provides further support for targeting LAMP3 as a therapeutic approach in SjD.

Association of G protein‐coupled receptor 78 with salivary dysfunction in male Sjögren's patients
Tsutomu Tanaka, Maria Cambraia Guimaro Diniz, Hiroyuki Nakamura, Paola Perez, Youngmi Ji, Drew G. Michael, Sandra A. Afione, Changyu Zheng, Corinne Goldsmith, William D. Swaim, Anne Marie Lynge Pedersen, John A. Chiorini
Oral Diseases, Wiley, 18 Jan. 2023, [Lead author]
English, Scientific journal

Correction of LAMP3-associated salivary gland hypofunction by aquaporin gene therapy
Hiroyuki Nakamura, Tsutomu Tanaka, Changyu Zheng, Sandra A. Afione, Blake M. Warner, Masayuki Noguchi, Tatsuya Atsumi, John A. Chiorini
Scientific Reports, 12, 1, 18570, Springer Science and Business Media {LLC}, 03 Nov. 2022, [Lead author]
English, Scientific journal, AbstractSjögren’s disease (SjD) is a chronic autoimmune sialadenitis resulting in salivary gland hypofunction with dry mouth symptom. Previous studies showed that lysosome-associated membrane protein 3 (LAMP3) overexpression is involved in the development of salivary gland hypofunction associated with SjD. However, the molecular mechanisms are still unclear, and no effective treatment exists to reverse gland function in SjD. Analysis on salivary gland samples from SjD patients showed that salivary gland hypofunction was associated with decreased expression of sodium–potassium-chloride cotransporter-1 (NKCC1) and aquaporin 5 (AQP5), which are membrane proteins involved in salivation. Further studies revealed that LAMP3 overexpression decreased their expression levels by promoting endolysosomal degradation. Additionally, we found that LAMP3 overexpression enhanced gene transfer by increasing internalization of adeno-associated virus serotype 2 (AAV2) via the promoted endolysosomal pathway. Retrograde cannulation of AAV2 vectors encoding AQP1 gene (AAV2-AQP1) into salivary glands induced glandular AQP1 expression sufficient to restore salivary flow in LAMP3-overexpressing mice. LAMP3 could play a critical role in the development of salivary gland hypofunction in SjD by promoting endolysosomal degradation of NKCC1 and AQP5. But it also could enhance AAV2-mediated gene transfer to restore fluid movement through induction of AQP1 expression. These findings suggested that AAV2-AQP1 gene therapy is useful in reversing salivary gland function in SjD patients.

Indocyanine green conjugated phototheranostic nanoparticle for photodiagnosis and photodynamic therapy
Kenta Shinoda, Akiko Suganami, Yasumitsu Moriya, Masamichi Yamashita, Tsutomu Tanaka, Akane S. Suzuki, Hiroshi Suito, Yasunori Akutsu, Kengo Saito, Yoko Shinozaki, Kazuoki Isojima, Naohito Nakamura, Yasushi Miyauchi, Hiroshi Shirasawa, Hisahiro Matsubara, Yoshiharu Okamoto, Toshinori Nakayama, Yutaka Tamura
Photodiagnosis and Photodynamic Therapy, 39, 103041, 103041, Elsevier BV, Sep. 2022
Scientific journal

Enteric viruses replicate in salivary glands and infect through saliva
S. Ghosh, M. Kumar, M. Santiana, A. Mishra, M. Zhang, H. Labayo, A. M. Chibly, H. Nakamura, T. Tanaka, W. Henderson, E. Lewis, O. Voss, Y. Su, Y. Belkaid, J. A. Chiorini, M. P. Hoffman, N. Altan-Bonnet
Nature, 14 Jul. 2022
Scientific journal

LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization
Tsutomu Tanaka, Blake M. Warner, Drew G. Michael, Hiroyuki Nakamura, Toshio Odani, Hongen Yin, Tatsuya Atsumi, Masayuki Noguchi, John A. Chiorini
Autophagy, 03 Jul. 2022, [Lead author]
Scientific journal

Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjögren’s syndrome
Ying-Qian Mo, Hiroyuki Nakamura, Tsutomu Tanaka, Toshio Odani, Paola Perez, Youngmi Ji, Benjamin N. French, Thomas J.F. Pranzatelli, Drew G. Michael, Hongen Yin, Susan S. Chow, Maryam Khalaj, Sandra A. Afione, Changyu Zheng, Fabiola Reis Oliveira, Ana Carolina F. Motta, Alfredo Ribeiro-Silva, Eduardo M. Rocha, Cuong Q. Nguyen, Masayuki Noguchi, Tatsuya Atsumi, Blake M. Warner, John A. Chiorini
Journal of Clinical Investigation, American Society for Clinical Investigation, 15 Mar. 2022, [Lead author]
Scientific journal

Lysosome-associated membrane protein 3 misexpression in salivary glands induces a Sjögren’s syndrome-like phenotype in mice
Hiroyuki Nakamura, Tsutomu Tanaka, Thomas Pranzatelli, Youngmi Ji, Hongen Yin, Paola Perez, S, ra A Afione, Shyh-Ing Jang, Corrine Goldsmith, Chang Yu Zheng, William D Swaim, Blake M Warner, Noriyuki Hirata, Masayuki Noguchi, Tatsuya Atsumi, John A Chiorini
Annals of the Rheumatic Diseases, 80, 8, 1031, 1039, {BMJ}, 03 Mar. 2021, [Lead author]
English, Scientific journal, ObjectivesSjögren’s syndrome (SS) is an autoimmune sialadenitis with unknown aetiology. Although extensive research implicated an abnormal immune response associated with lymphocytes, an initiating event mediated by salivary gland epithelial cell (SGEC) abnormalities causing activation is poorly characterised. Transcriptome studies have suggested alternations in lysosomal function are associated with SS, but a cause and effect linkage has not been established. In this study, we demonstrated that altered lysosome activity in SGECs by expression of lysosome-associated membrane protein 3 (LAMP3) can initiate an autoimmune response with autoantibody production and salivary dysfunction similar to SS.MethodsRetroductal cannulation of the submandibular salivary glands with an adeno-associated virus serotype 2 vector encoding LAMP3 was used to establish a model system. Pilocarpine-stimulated salivary flow and the presence of autoantibodies were assessed at several time points post-cannulation. Salivary glands from the mice were evaluated using RNAseq and histologically.ResultsFollowing LAMP3 expression, saliva flow was significantly decreased and serum anti-Ro/SSA and La/SSB antibodies could be detected in the treated mice. Mechanistically, LAMP3 expression increased apoptosis in SGECs and decreased protein expression related to saliva secretion. Analysis of RNAseq data suggested altered lysosomal function in the transduced SGECs, and that the cellular changes can chemoattract immune cells into the salivary glands. Immune cells were activated via toll-like receptors by damage-associated molecular patterns released from LAMP3-expressing SGECs.ConclusionsThese results show a critical role for lysosomal trafficking in the development of SS and establish a causal relationship between LAMP3 misexpression and the development of SS.

Rescue of Adeno-Associated Virus Production by shRNA Cotransfection
Tsutomu Tanaka, Maria C. Guimaro, Sandra A. Afione, Tsutomu Tanaka, John A. Chiorini
Human Gene Therapy, 31, 19-20, 1068, 1073, Mary Ann Liebert Inc, 01 Oct. 2020
English, Scientific journal

LAMP3 induces apoptosis and autoantigen release in Sjögren’s syndrome patients
Tsutomu Tanaka, Blake M. Warner, Toshio Odani, Youngmi Ji, Ying-Qian Mo, Hiroyuki Nakamura, Shyh-Ing Jang, Hongen Yin, Drew G. Michael, Noriyuki Hirata, Futoshi Suizu, Satoko Ishigaki, Fabiola Reis Oliveira, Ana Carolina F. Motta, Alfredo Ribeiro-Silva, Eduardo M. Rocha, Tatsuya Atsumi, Masayuki Noguchi, John A. Chiorini
Scientific Reports, 10, 1, 15169, 15169, Springer Science and Business Media {LLC}, 16 Sep. 2020, [Lead author], [International Magazine]
English, Scientific journal, AbstractPrimary Sjögren’s syndrome (pSS) is a complex autoimmune disease characterized by dysfunction of secretory epithelia with only palliative therapy. Patients present with a constellation of symptoms, and the diversity of symptomatic presentation has made it difficult to understand the underlying disease mechanisms. In this study, aggregation of unbiased transcriptome profiling data sets of minor salivary gland biopsies from controls and Sjögren’s syndrome patients identified increased expression of lysosome-associated membrane protein 3 (LAMP3/CD208/DC-LAMP) in a subset of Sjögren’s syndrome cases. Stratification of patients based on their clinical characteristics suggested an association between increased LAMP3 expression and the presence of serum autoantibodies including anti-Ro/SSA, anti-La/SSB, anti-nuclear antibodies. In vitro studies demonstrated that LAMP3 expression induces epithelial cell dysfunction leading to apoptosis. Interestingly, LAMP3 expression resulted in the accumulation and release of intracellular TRIM21 (one component of SSA), La (SSB), and α-fodrin protein, common autoantigens in Sjögren’s syndrome, via extracellular vesicles in an apoptosis-independent mechanism. This study defines a clear role for LAMP3 in the initiation of apoptosis and an independent pathway for the extracellular release of known autoantigens leading to the formation of autoantibodies associated with this disease.ClinicalTrials.gov Identifier: NCT00001196, NCT00001390, NCT02327884.

Autophagy as a modulator of cell death machinery
Masayuki Noguchi, Noriyuki Hirata, Tsutomu Tanaka, Futoshi Suizu, Hiroshi Nakajima, John A. Chiorini
Cell Death & Disease, 11, 7, Springer Science and Business Media {LLC}, 08 Jul. 2020
English, Scientific journal, AbstractThe balance between cell death and survival is a critical parameter in the regulation of cells and the maintenance of homeostasis in vivo. Three major mechanisms for cell death have been identified in mammalian cells: apoptosis (type I), autophagic cell death (type II), and necrosis (type III). These three mechanisms have been suggested to engage in cross talk with each other. Among them, autophagy was originally characterized as a cell survival mechanism for amino acid recycling during starvation. Whether autophagy functions primarily in cell survival or cell death is a critical question yet to be answered. Here, we present a comprehensive review of the cell death-related events that take place during autophagy and their underlying mechanisms in cancer and autoimmune disease development.

Identification of RNA aptamer which specifically interacts with PtdIns(3)P
Thoria Donia, Bala Jyoti, Futoshi Suizu, Noriyuki Hirata, Tsutomu Tanaka, Satoko Ishigaki, Pranzatelli Thomas J. F, Junko Nio-Kobayashi, Toshihiko Iwanaga, John A. Chiorini, Masayuki Noguchi
Biochemical and Biophysical Research Communications, 517, 1, 146, 154, Elsevier {BV}, 24 Jul. 2019, [International Magazine]
English, Scientific journal, The phosphinositide PtdIns(3)P plays an important role in autophagy; however, the detailed mechanism of its activity remains unclear. Here, we used a Systematic Evolution of Ligands by EXponential enrichment (SELEX) screening approach to identify an RNA aptamer of 40 nucleotides that specifically recognizes and binds to intracellular lysosomal PtdIns(3)P. Binding occurs in a magnesium concentration- and pH-dependent manner, and consequently inhibits autophagy as determined by LC3II/I conversion, p62 degradation, formation of LC3 puncta, and lysosomal accumulation of Phafin2. These effects in turn inhibited lysosomal acidification, and the subsequent hydrolytic activity of cathepsin D following induction of autophagy. Given the essential role of PtdIns(3)P as a key targeting molecule for autophagy induction, identification of this novel PtdIns(3)P RNA aptamer provides new opportunities for investigating the biological functions and mechanisms of phosphoinositides.

Functional characterization of lysosomal interaction of Akt with VRK2
Noriyuki Hirata, Futoshi Suizu, Mami Matsuda-Lennikov, Tsutomu Tanaka, Tatsuma Edamura, Satoko Ishigaki, Thoria Donia, Pathrapol Lithanatudom, Chikashi Obuse, Toshihiko Iwanaga, Masayuki Noguchi
Oncogene, 37, 40, 5367, 5386, Springer Science and Business Media {LLC}, Oct. 2018
English, Scientific journal

Cancer-associated oxidoreductase ERO1-α promotes immune escape through up-regulation of PD-L1 in human breast cancer
Tsutomu Tanaka, Goro Kutomi, Toshimitsu Kajiwara, Kazuharu Kukita, Vitaly Kochin, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Toshihiko Torigoe, Yoshiharu Okamoto, Koichi Hirata, Noriyuki Sato, Yasuaki Tamura
Oncotarget, 8, 15, 24706, 24718, Impact Journals, {LLC}, 11 Apr. 2017, [Lead author]
English, Scientific journal

Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-α-mediated oxidative folding in murine tumor cells
Toshimitsu Kajiwara, Tsutomu Tanaka, Kazuharu Kukita, Goro Kutomi, Keita Saito, Koichi Okuya, Akari Takaya, Vitaly Kochin, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Toshihiko Torigoe, Koichi Hirata, Noriyuki Sato, Yasuaki Tamura
European Journal of Immunology, 46, 12, 2842, 2851, Wiley, Dec. 2016
English, Scientific journal

Plasticity of lung cancer stem-like cells is regulated by the transcription factor HOXA5 that is induced by oxidative stress
Hiroshi Saijo, Yoshihiko Hirohashi, Toshihiko Torigoe, Ryota Horibe, Akari Takaya, Aiko Murai, Terufumi Kubo, Toshimitsu Kajiwara, Tsutomu Tanaka, Yosuke Shionoya, Eri Yamamoto, Reo Maruyama, Munehide Nakatsugawa, Takayuki Kanaseki, Tomohide Tsukahara, Yasuaki Tamura, Yasushi Sasaki, Takashi Tokino, Hiromu Suzuki, Toru Kondo, Hiroki Takahashi, Noriyuki Sato
Oncotarget, 7, 31, 50043, 50056, Impact Journals, {LLC}, 02 Aug. 2016
English, Scientific journal

Phosphorylation‐dependent Akt–Inversin interaction at the basal body of primary cilia
Futoshi Suizu, Noriyuki Hirata, Kohki Kimura, Tatsuma Edamura, Tsutomu Tanaka, Satoko Ishigaki, Thoria Donia, Hiroko Noguchi, Toshihiko Iwanaga, Masayuki Noguchi
The EMBO Journal, 35, 12, 1346, 1363, {EMBO}, 15 Jun. 2016, [International Magazine]
English, Scientific journal, A primary cilium is a microtubule-based sensory organelle that plays an important role in human development and disease. However, regulation of Akt in cilia and its role in ciliary development has not been demonstrated. Using yeast two-hybrid screening, we demonstrate that Inversin (INVS) interacts with Akt. Mutation in the INVS gene causes nephronophthisis type II (NPHP2), an autosomal recessive chronic tubulointerstitial nephropathy. Co-immunoprecipitation assays show that Akt interacts with INVS via the C-terminus. In vitro kinase assays demonstrate that Akt phosphorylates INVS at amino acids 864-866 that are required not only for Akt interaction, but also for INVS dimerization. Co-localization of INVS and phosphorylated form of Akt at the basal body is augmented by PDGF-AA Akt-null MEF cells as well as siRNA-mediated inhibition of Akt attenuated ciliary growth, which was reversed by Akt reintroduction. Mutant phosphodead- or NPHP2-related truncated INVS, which lack Akt phosphorylation sites, suppress cell growth and exhibit distorted lumen formation and misalignment of spindle axis during cell division. Further studies will be required for elucidating functional interactions of Akt-INVS at the primary cilia for identifying the molecular mechanisms underlying NPHP2.

Cancer-associated oxidoreductase ERO1-α drives the production of VEGF via oxidative protein folding and regulating the mRNA level
Tsutomu Tanaka, Goro Kutomi, Toshimitsu Kajiwara, Kazuharu Kukita, Vitaly Kochin, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Toshihiko Torigoe, Yoshiharu Okamoto, Koichi Hirata, Noriyuki Sato, Yasuaki Tamura
British Journal of Cancer, 114, 11, 1227, 1234, Springer Science and Business Media {LLC}, 24 May 2016, [Lead author, Corresponding author]
English, Scientific journal

Primary Cilium-Mediated Crosstalk of Signaling Cascades in Ciliogenesis: Implications for Tumorigenesis and Senescence
Futoshi Suizu, Noriyuki Hirata, Satoko Ishigaki, Tatsuma Edamura, Kohki Kimura, Tsutomu Tanaka, Masayuki Noguchi
Cell Communication Insights, 8, 13, 24, Portico, 19 May 2016
Scientific journal

Liposomally formulated phospholipid-conjugated indocyanine green for intra-operative brain tumor detection and resection
Akiko Suganami, Yasuo Iwadate, Sayaka Shibata, Masamichi Yamashita, Tsutomu Tanaka, Natsuki Shinozaki, Ichio Aoki, Naokatsu Saeki, Hiroshi Shirasawa, Yoshiharu Okamoto, Yutaka Tamura
International Journal of Pharmaceutics, 496, 2, 401, 406, Elsevier {BV}, 30 Dec. 2015
English, Scientific journal

CpG-A stimulates Hsp72 secretion from plasmacytoid dendritic cells, facilitating cross-presentation
Tsutomu Tanaka, Toshimitsu Kajiwara, Goro Kutomi, Takehiro Kurotaki, Keita Saito, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Toshihiko Torigoe, Koichi Hirata, Yoshiharu Okamoto, Noriyuki Sato, Yasuaki Tamura
Immunology Letters, 167, 1, 34, 40, Elsevier {BV}, Sep. 2015, [Lead author]
English, Scientific journal

Cancer-Associated Oxidase ERO1-α Regulates the Expression of MHC Class I Molecule via Oxidative Folding
Kazuharu Kukita, Yasuaki Tamura, Tsutomu Tanaka, Toshimitsu Kajiwara, Goro Kutomi, Keita Saito, Koichi Okuya, Akari Takaya, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Toshihiko Torigoe, Tomohisa Furuhata, Koichi Hirata, Noriyuki Sato
The Journal of Immunology, 194, 10, 4988, 4996, The American Association of Immunologists, 15 May 2015
English, Scientific journal

Cancer-Associated Oxidoreductase ERO1-α Drives the Production of Tumor-Promoting Myeloid-Derived Suppressor Cells via Oxidative Protein Folding
Tsutomu Tanaka, Toshimitsu Kajiwara, Toshihiko Torigoe, Yoshiharu Okamoto, Noriyuki Sato, Yasuaki Tamura
The Journal of Immunology, 194, 4, 2004, 2010, The American Association of Immunologists, 15 Feb. 2015, [Lead author]
English, Scientific journal

Heat shock protein 90 targets a chaperoned peptide to the static early endosome for efficient cross‐presentation by human dendritic cells
Tsutomu Tanaka, Koichi Okuya, Goro Kutomi, Akari Takaya, Toshimitsu Kajiwara, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Toshihiko Torigoe, Koichi Hirata, Yoshiharu Okamoto, Noriyuki Sato, Yasuaki Tamura
Cancer Science, 106, 1, 18, 24, Wiley, Jan. 2015, [Lead author]
English, Scientific journal

Human endoplasmic reticulum oxidoreductin 1-α is a novel predictor for poor prognosis of breast cancer
Goro Kutomi, Yasuaki Tamura, Tsutomu Tanaka, Toshimitsu Kajiwara, Kazuharu Kukita, Tousei Ohmura, Hiroaki Shima, Tomoko Takamaru, Fukino Satomi, Yasuyo Suzuki, Toshihiko Torigoe, Noriyuki Sato, Koichi Hirata
Cancer Science, 104, 8, 1091, 1096, Wiley, Aug. 2013
English, Scientific journal

Increased expression of lysosomal associated membrane protein (LAMP) 3 in the salivary glands of Sjögren’s syndrome patients can stimulate stalled autophagy and apoptosis.　　　　　　　　　　　　　　　
Tsutomu Tanaka, Blake M. Warner, Toshio Odani, Hongen Yin, Tatsuya Atsumi, Masayuki Noguchi, John A. Chiorini
The 14th International Sjögren’s Syndrome Symposium, Apr. 2018, Poster presentation
Apr. 2018

腫瘍高発現性酸化酵素ERO1-αはEMTを調節し肺転移を制御する　　　　　　　　　　　　　　　
田中 努, 田村 保明, 梶原 敏充, 鳥越 俊彦, 岡本 芳晴, 佐藤 昇志
第10回日本臨床ストレス応答学会大会, Nov. 2015, Oral presentation
Nov. 2015

Cancer specific oxidase ERO1-α promotes the immune escape via up-regulation of PD-L1.　　　　　　　　　　　　　　　
田中 努, 田村 保明, 梶原 敏充, 九冨 五郎, 鳥越 俊彦, 岡本 芳晴, 平田 公一, 佐藤 昇志
第74回日本癌学会総会, Oct. 2015, Oral presentation
Oct. 2015

Enhanced expression of ERO1-α within tumors regulates the condition for tumor growth in vivo.　　　　　　　　　　　　　　　
田中 努, 田村 保明, 梶原 敏充, 鳥越 俊彦, 岡本 芳晴, 佐藤 昇志
第104回日本病理学会総会, Apr. 2015, Oral presentation
Apr. 2015

腫瘍に高発現する酸化酵素ERO1-αは、腫瘍増殖環境を整える　　　　　　　　　　　　　　　
田中 努, 田村 保明, 梶原 敏充, 鳥越 俊彦, 岡本 芳晴, 佐藤 昇志
第9回日本臨床ストレス応答学会大会, Nov. 2014, Oral presentation
Nov. 2014

Enhanced expression of endoplasmic reticulum oxidoreductin 1-α (ERO1-α) promotes tumor growth and pulmonary metastasis.　　　　　　　　　　　　　　　
田中 努, 田村 保明, 梶原 敏充, 鳥越 俊彦, 岡本 芳晴, 佐藤 昇志
第73回日本癌学会総会, Sep. 2014, Poster presentation
Sep. 2014

腫瘍に高発現する酸化酵素ERO1-αは癌幹細胞形質の維持に関与する　　　　　　　　　　　　　　　
田中 努, 田村 保明, 久木田 和晴, 梶原 敏充, 鳥越 俊彦, 岡本 芳晴, 佐藤 昇志
第103回日本病理学会総会, Apr. 2014, Oral presentation
Apr. 2014

Enhanced expression of endoplasmic reticulum disulfide oxidase 1-α (ERO1-α) inhibits anti-tumor immune response.　　　　　　　　　　　　　　　
田中 努, 田村 保明, 久木田 和晴, 梶原 敏充, 鳥越 俊彦, 岡本 芳晴, 佐藤 昇志
第72回日本癌学会総会, Oct. 2013, Oral presentation
Oct. 2013

腫瘍に高発現する酸化酵素ERO1-αは、抗腫瘍免疫応答を抑制する　　　　　　　　　　　　　　　
田中 努, 田村 保明, 久木田 和晴, 梶原 敏充, 鳥越 俊彦, 岡本 芳晴, 佐藤 昇志
第102回日本病理学会総会, Jun. 2013, Oral presentation
Jun. 2013

2015 - Present
日本免疫学会　　　　　　　　　　　　　　　

2013 - Present
日本病理学会　　　　　　　　　　　　　　　

2012 - Present
日本癌学会