2003, がん研究助成金　　　　　　　　　　　　　　　
Japan

CD19陽性再発難治B細胞性急性リンパ性白血病に対する移植後ブリナツモマブ維持療法の第1相試験:SCT-ALL-BLIN21(Phase 1 study for post-transplant maintenance therapy with blinatumomab for CD19+ relapsed/refractory B-cell acute lymphoblastic leukemia: SCT-ALL-BLIN21)　　　　　　　　　　　　　　　
Sakaguchi Hirotoshi, Noma Hisashi, Ishida Hiroyuki, Goto Hiroaki, Sakaguchi Kimiyoshi, Kato Itaru, Kawahara Yuta, Sanada Masashi, Deguchi Takao, Takahashi Yoshiyuki, Saito Akiko, Horibe Keizo, Koh Katsuyoshi, Manabe Atsushi, Umeda Katsutsugu
日本小児血液・がん学会雑誌, 61, 4, 231, 231, (一社)日本小児血液・がん学会, Jan. 2025
English

Long-term outcome and social-intellectual ability of patients with basal ganglia germinoma
Michinari Okamoto, Shigeru Yamaguchi, Ryosuke Sawaya, Yukitomo Ishi, Hiroaki Motegi, Yukayo Terashita, Minako Sugiyama, Yuko Cho, Kentaro Nishioka, Takashi Mori, Takayuki Hashimoto, Hidefumi Aoyama, Atsushi Manabe, Miki Fujimura
Pediatric Neurology, Elsevier BV, Jan. 2025
Scientific journal

Comparison of busulfan pharmacokinetics between four-times-daily and once-daily administration in pediatric patients: a preliminary prospective observational trial
Atsushi Yamaguchi, Shinsuke Hirabayashi, Kazuko Niki, Keisuke Kagami, Yukayo Terashita, Yuko Cho, Atsushi Manabe, Mitsuru Sugawara, Yoh Takekuma
International Journal of Hematology, Springer Science and Business Media LLC, 03 Dec. 2024
Scientific journal

Outcomes in children with first-relapsed acute lymphoblastic leukemia in Japan: Results from JCCG Study JPLSG-ALL-R08.
Junko Yamanaka, Chitose Ogawa, Ayumu Arakawa, Takao Deguchi, Toshinori Hori, Nobutaka Kiyokawa, Hideaki Ueki, Masanori Nishi, Shinji Mochizuki, Takuro Nishikawa, Tadashi Kumamoto, Ritsuo Nishiuchi, Atsushi Kikuta, Shohei Yamamoto, Katsuyoshi Koh, Daisuke Hasegawa, Atsushi Ogawa, Kenichiro Watanabe, Atsushi Sato, Akiko M Saito, Tomoyuki Watanabe, Atsushi Manabe, Keizo Horibe, Hiroaki Goto, Hidemi Toyoda
Pediatric blood & cancer, 71, 12, e31319, Dec. 2024, [International Magazine]
English, Scientific journal, BACKGROUND/OBJECTIVES: The Berlin-Frankfurt-Münster (BFM)-S classification is a crucial prognostic indicator in children experiencing first-relapsed acute lymphoblastic leukemia (ALL). Early molecular response to therapy, evaluated by measurable/minimal residual disease (MRD), has a significant impact on the survival of patients with childhood ALL. Applying risk stratification based on the BFM-S classification and MRD response after induction, the first nationwide prospective multicenter study, ALL-R08, was conducted in children with first-relapsed ALL in Japan. METHODS: The ALL-R08 study comprised two parts: ALL-R08-I, an observational study aimed at obtaining an overall picture of outcomes in first-relapsed childhood ALL, and ALL-R08-II, a clinical trial for the non-T-ALL S2 risk group. In ALL-R08-II, patients with an MRD level of ≥10-3 at the end of induction therapy were assigned to undergo allogeneic hematopoietic stem cell transplantation (allo-HCT), whereas those with an MRD level less than 10-3 and isolated extramedullary relapse continued to receive chemotherapy. RESULTS: In total, 163 patients were enrolled in the ALL-R08 study, and 82 and 81 patients were enrolled in the ALL-R08-I and the ALL-R08-II, respectively. In ALL-R08-I, the probability of 3-year event-free survival (EFS) for patients with S1, S2, S3, S4, and post-HCT groups was 83% ± 15%, 37% ± 11%, 28% ± 8%, 14% ± 7%, and 0%, respectively. In the ALL-R08-II trial, 3-year EFS in patients with post-induction MRD less than 10-3 and ≥10-3 was 70% ± 9% (n = 27) and 68% ± 8% (n = 31) (p = .591), respectively. CONCLUSIONS: ALL-REZ BFM-type treatment is equally effective for children with first-relapsed ALL treated according to the Japanese frontline protocols and for children with first-relapsed ALL treated according to the BFM-type frontline protocols.

Real-world outcomes of commercial tisagenlecleucel for children, adolescents, and young adults with acute lymphoblastic leukemia in Japan.
Itaru Kato, Daisuke Tomizawa, Motohiro Kato, Shinsuke Hirabayashi, Atsushi Manabe, Masahiro Irie, Yoji Sasahara, Yuki Arakawa, Katsuyoshi Koh, Hirotoshi Sakaguchi, Masanaka Sugiyama, Chitose Ogawa, Takahiro Kamiya, Shoji Saito, Yozo Nakazawa, Nobuhiro Nishio, Yoshiyuki Takahashi, Naoko Iwai, Souichi Adachi, Junko Takita, Takako Miyamura, Satomi Yokoyama, Utako Oba, Tamaki Ueda, Yuhki Koga, Hidefumi Hiramatsu
Transplantation and cellular therapy, 29 Nov. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: Chimeric antigen receptor (CAR) T cells are a major new treatment option for children, adolescents, and young adults (CAYA) patients with relapsed and refractory (R/R) B cell acute lymphoblastic leukemia (B-ALL). Therefore, accumulating evidence from real-world experiences of CAR-T outcomes in various regions world-wide is important, particularly when comparing outcomes of patients with differing medical and ethnic backgrounds. OBJECTIVE: More than 5 years have passed since tisagenlecleucel was approved in Japan. Here, we report a retrospective, multi-institutional investigation examining the association between baseline parameters and clinical outcomes. The aim was to investigate real-world experience, and to better comprehend the efficacy of commercial tisagenlecleucel. STUDY DESIGN: A nationwide consortium called the Japan CAR-T Consortium conducted a retrospective, multicenter study of CAYA patients who received CAR-T cell treatment with commercial tisagenlecleucel. Forty-two patients with R/R B-ALL whose leukapheresis samples were shipped to Novartis for commercial tisagenlecleucel manufacture were included in the analysis. All infused patients were included in the response, toxicity, and survival analyses. RESULTS: The best overall response rate was 93%. The 1-year overall survival (OS) and event-free survival (EFS) rates after infusion were 82% and 56%, respectively. Twenty-seven (64%) had low disease burden (LB, defined as <5% bone marrow [BM] lymphoblasts) prior to tisagenlecleucel infusion. LB was associated with superior outcomes, with a 1-year EFS rate of 80% compared with 24% in high disease burden (≧5% BM lymphoblasts). Multivariate analysis identified an association between prior hematopoietic stem cell transplantation (HSCT) (n=23, 55%) and superior outcomes, with a 1-year EFS rate of 75% compared with 24% for patients without prior HSCT. CONCLUSION: This first analysis of CAYA patients with R/R B-ALL undergoing treatment with commercial tisagenlecleucel in Japan reports an efficacy similar to that in clinical trials and other real-world studies and confirms that LB and prior HSCT are associated with superior EFS.

Serum 5-S-cysteinyldopa as a predictive biomarker for stem cell transplantation-related complications in children and young adults.
Yukayo Terashita, Akihiro Iguchi, Minako Sugiyama, Yuko Cho, Houman Goudarzi, Isao Yokota, Atsushi Manabe
Blood cell therapy, 7, 4, 111, 117, 25 Nov. 2024, [Domestic magazines]
English, Scientific journal, Diffuse hyperpigmentation is common in patients who undergo chemotherapy or stem cell transplantation (SCT). However, only a few studies have reported the relation between skin reactions and SCT-related complications. Serum 5-S-cysteinyldopa (5SCD), a pheomelanin precursor, is elevated in individuals with hyperpigmentation. Here, we serially examined 5SCD levels during SCT to determine their association with SCT-related complications. We prospectively analyzed serum 5SCD levels in 41 patients (median age: 7.9 years; range: 0-22 years) who underwent SCT (allogeneic in 34 patients and autologous in 7 patients). The serum level of 5SCD increased on day 0, remained high on day 5, and gradually decreased to baseline levels on day 40 after SCT. An increase in 5SCD levels on day 0 was associated with the presence of viral reactivation (odds ratio [OR]: 3.32; 95% confidence interval [CI] 1.07-10.21, p = 0.002) while an increase in 5SCD levels on day 5 was associated with pre-engraftment syndrome (OR: 2.18; 95% CI 1.11-4.26, p = 0.007). In patients who underwent allogeneic SCT, the difference between the baseline level of 5SCD before SCT and the highest level after SCT was associated with acute graft-versus-host disease (GVHD) (OR for a 10 nmol/L increase in biomarker levels: 1.90; 95% CI 1.04-3.45, p = 0.015) and acute cutaneous GVHD (OR for a 10 nmol/L increase in biomarker levels: 2.34; 95%CI 1.11-4.52, p = 0.005). The conditioning regimen was not associated with serum 5SCD levels. Therefore, this study demonstrated the potential of 5SCD as a predictive biomarker for SCT-related complications, such as viral reactivation, pre-engraftment syndrome, and acute GVHD.

JCCG ALL-B12: Evaluation of Intensified Therapies With Vincristine/Dexamethasone Pulses and Asparaginase and Augmented High-Dose Methotrexate for Pediatric B-ALL.
Motohiro Kato, Yasuhiro Okamoto, Toshihiko Imamura, Akiko Kada, Akiko M Saito, Yuka Iijima-Yamashita, Takao Deguchi, Kentaro Ohki, Takashi Fukushima, Kenichi Anami, Masashi Sanada, Tomohiko Taki, Yoshiko Hashii, Takeshi Inukai, Nobutaka Kiyokawa, Yoshiyuki Kosaka, Nao Yoshida, Yuki Yuza, Masakatsu Yanagimachi, Kenichiro Watanabe, Atsushi Sato, Chihaya Imai, Takashi Taga, Souichi Adachi, Keizo Horibe, Atsushi Manabe, Katsuyoshi Koh
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, JCO2400811, 12 Nov. 2024, [International Magazine]
English, Scientific journal, PURPOSE: The JCCG ALL-B12 clinical trial aimed to evaluate the effectiveness of unvalidated treatment phases for pediatric ALL and develop a safety-focused treatment framework. PATIENTS AND METHODS: Patients age 1-19 years with newly diagnosed B-ALL were enrolled in this study. These patients were stratified into standard-risk (SR), intermediate-risk (IR), and high-risk (HR) groups. Randomized comparisons assessed the effectiveness of vincristine (VCR)/dexamethasone pulses in the SR group, evaluated the effects of L-asparaginase (ASP) intensification in the IR group, and compared standard consolidation including block-type treatment with experimental consolidation with high-dose methotrexate (HD-MTX) intensified with VCR and ASP in the HR group. RESULTS: Of 1,936 patients enrolled, 1,804 were eligible for the experimental treatment. The overall 5-year event-free survival and overall survival rates were 85.2% (95% CI, 83.5 to 86.8) and 94.3% (95% CI, 93.1 to 95.3), respectively. The cumulative incidence of relapse and postremission nonrelapse mortality was 13.2% (95% CI, 11.6 to 14.8) and 0.6% (95% CI, 0.3 to 1.0), respectively. Random assignment in the SR group showed no significant benefit from pulse therapy. In the IR group, ASP intensification had limited effects. In the HR group, standard block therapy and HD-MTX yielded equivalent outcomes. CONCLUSION: The ALL-B12 trial achieved favorable outcomes in a nationwide cohort by stratifying treatment on the basis of risk and balancing treatment intensity. This study not only demonstrated that existing standard of care can be further refined but also indicated that improvement in outcomes with intensified chemotherapy has reached a plateau.

Increased response to granulocyte-macrophage colony-stimulating factor in peripheral blood cells and transient manifestations mimicking juvenile myelomonocytic leukemia in a male patient with NEMO deficiency caused by a deep intronic pathogenic variant of IKBKG.
Masahiro Ueki, Shinsuke Hirabayashi, Yoshitaka Honda, Shunichiro Takezaki, Hiroki Ohata, Shimaa Said Mohamed Ali Abdrabou, Saori Sawai, Yukayo Terashita, Yuko Cho, Hideki Muramatsu, Kazushi Izawa, Takahiro Yasumi, Yoshiyuki Takahashi, Masafumi Yamada, Atsushi Manabe
Immunological medicine, 1, 8, 01 Nov. 2024, [International Magazine]
English, Scientific journal, X-linked NF-κB essential modulator (NEMO) deficiency is a primary immunodeficiency characterized by combined immunodeficiency and ectodermal dysplasia. Monocytes from the patients demonstrate a severely impaired response to tissue necrosis factor or lipopolysaccharide, whereas hyper-inflammation is found in some patients. Juvenile myelomonocytic leukemia (JMML) is a pediatric malignancy caused by hypersensitivity to granulocyte-macrophage colony-stimulating factor (GM-CSF) and aberrant RAS signaling activation. Patients with JMML demonstrate characteristic manifestations such as splenomegaly, monocytosis and the presence of myeloid or erythroid precursors in the peripheral blood. Here, we present the case of a male infant with ectodermal dysplasia, bacterial septicemia, Pneumocystis pneumonia, severe inflammation and transient manifestations mimicking JMML. Genetic analysis revealed a deep intronic germline variant of IKBKG. Full-length IKBKG cDNA and NEMO protein expression were almost inexistent. Peripheral mononuclear cells (PBMCs) from the patient showed increased RAS signaling activation with GM-CSF or Phorbol 12-myristate 13-acetate without the RAS-associated gene variant, although the increased RAS signaling activation in induced-pluripotent stem cell-derived myeloid lineage and bone marrow-derived mesenchymal cells was not evident. The patient with NEMO deficiency demonstrated JMML-like manifestation and severe inflammation. PBMCs of the patient demonstrated increased RAS signaling activation with unknown pathophysiology.

小児造血幹細胞移植におけるブスルファンの1日4回投与法と1日1回投与法による薬物動態パラメータの比較
山口 敦史, 平林 真介, 仁木 加寿子, 鏡 圭介, 寺下 友佳代, 長 祐子, 真部 淳, 菅原 満, 武隈 洋
TDM研究, 41, 2, 155, 155, (一社)日本TDM学会, Jul. 2024
Japanese

Biologic and clinical analysis of childhood gamma delta T-ALL identifies LMO2/STAG2 rearrangements as extremely high-risk.
Shunsuke Kimura, Chun Shik Park, Lindsey E Montefiori, Ilaria Iacobucci, Petri Polonen, Qingsong Gao, Elizabeth D Arnold, Andishe Attarbaschi, Anthony Brown, Barbara Buldini, Kenneth J Caldwell, Yunchao Chang, Chelsey Chen, Cheng Cheng, Zhongshan Cheng, John Choi, Valentino Conter, Kristine R Crews, Hester A de Groot-Kruseman, Takao Deguchi, Mariko Eguchi, Hannah Elisa Muhle, Sarah Elitzur, Gabriele Escherich, Burgess B Freeman, Zhaohui Gu, Katie Han, Keizo Horibe, Toshihiko Imamura, Sima Jeha, Motohiro Kato, Kean Hui Chiew, Tanya Khan, Michal Kicinski, Stefan Kohrer, Steven M Kornblau, Rishi S Kotecha, Chi-Kong Li, Yen-Chun Liu, Franco Locatelli, Selina M Luger, Elisabeth M Paietta, Atsushi Manabe, Hanne Vibeke Marquart, Riccardo Masetti, Mellissa Maybury, Pauline Mazilier, Jules P P Meijerink, Sharnise Mitchell, Takako Miyamura, Andrew S Moore, Koichi Oshima, Katarzyna Pawinska-Wasikowska, Rob Pieters, Mollie S Prater, Shondra M Pruett-Miller, Ching-Hon Pui, Chunxu Qu, Michaela Reiterova, Noemi Reyes, Kathryn G Roberts, Jacob M Rowe, Atsushi Sato, Kjeld Schmiegelow, Martin Schrappe, Shuhong Shen, Szymon Skoczen, Orietta Spinelli, Jan Stary, Michael Svaton, Masatoshi Takagi, Junko Takita, Yanjing Tang, David T Teachey, Paul G Thomas, Daisuke Tomizawa, Jan Trka, Elena Varotto, Tiffaney L Vincent, Jun J Yang, Allen Ej Yeoh, Yinmei Zhou, Martin Zimmermann, Hiroto Inaba, Charles G Mullighan
Cancer discovery, 25 Jun. 2024, [International Magazine]
English, Scientific journal, Acute lymphoblastic leukemia expressing the gamma delta T cell receptor (yo T-ALL) is a poorly understood disease. We studied 200 children with yo T-ALL from 13 clinical study groups to understand the clinical and genetic features of this disease. We found age and genetic drivers were significantly associated with outcome. yo T-ALL diagnosed in children under three years of age was extremely high-risk and enriched for genetic alterations that result in both LMO2 activation and STAG2 inactivation. Mechanistically, using patient samples and isogenic cell lines, we show that inactivation of STAG2 profoundly perturbs chromatin organization by altering enhancer-promoter looping, resulting in deregulation of gene expression associated with T-cell differentiation. High throughput drug screening identified a vulnerability in DNA repair pathways arising from STAG2 inactivation, which can be targeted by Poly(ADP-ribose) polymerase (PARP) inhibition. These data provide a diagnostic framework for classification and risk stratification of pediatric yo T-ALL.

Correction to: Prenatal metal concentrations and physical abnormalities in the Japan Environment and Children’s Study (Pediatric Research, (2023), 10.1038/s41390-023-02851-4)
Yuichi Nakamura, Sumitaka Kobayashi, Kazutoshi Cho, Sachiko Itoh, Chihiro Miyashita, Takeshi Yamaguchi, Hiroyoshi Iwata, Naomi Tamura, Yasuaki Saijo, Yoshiya Ito, Yoshitaka Seto, Ryota Honjo, Akiko Ando, Yuta Furuse, Atsushi Manabe, Reiko Kishi, Michihiro Kamijima, Shin Yamazaki, Yukihiro Ohya, Reiko Kishi, Nobuo Yaegashi, Koichi Hashimoto, Chisato Mori, Shuichi Ito, Zentaro Yamagata, Hidekuni Inadera, Takeo Nakayama, Tomotaka Sobue, Masayuki Shima, Hiroshige Nakamura, Narufumi Suganuma, Koichi Kusuhara, Takahiko Katoh
Pediatric Research, 95, 6, 1659, 1661, May 2024
Scientific journal

Identification of Prostaglandin I2 Synthase Rare Variants in Patients With Williams Syndrome and Severe Peripheral Pulmonary Stenosis.
Ayako Chida-Nagai, Hiroyuki Akagawa, Saori Sawai, Yue-Jiao Ma, Satoshi Yakuwa, Jun Muneuchi, Kazushi Yasuda, Hirokuni Yamazawa, Toshiyuki Yamamoto, Emi Takakuwa, Utano Tomaru, Yoshiyuki Furutani, Tatsuya Kato, Gen Harada, Kei Inai, Toshio Nakanishi, Atsushi Manabe, Atsuhito Takeda, Zhi-Cheng Jing
Journal of the American Heart Association, e032872, 19 Apr. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: Peripheral pulmonary stenosis (PPS) is a condition characterized by the narrowing of the pulmonary arteries, which impairs blood flow to the lung. The mechanisms underlying PPS pathogenesis remain unclear. Thus, the aim of this study was to investigate the genetic background of patients with severe PPS to elucidate the pathogenesis of this condition. METHODS AND RESULTS: We performed genetic testing and functional analyses on a pediatric patient with PPS and Williams syndrome (WS), followed by genetic testing on 12 patients with WS and mild-to-severe PPS, 50 patients with WS but not PPS, and 21 patients with severe PPS but not WS. Whole-exome sequencing identified a rare PTGIS nonsense variant (p.E314X) in a patient with WS and severe PPS. Prostaglandin I2 synthase (PTGIS) expression was significantly downregulated and cell proliferation and migration rates were significantly increased in cells transfected with the PTGIS p.E314X variant-encoding construct when compared with that in cells transfected with the wild-type PTGIS-encoding construct. p.E314X reduced the tube formation ability in human pulmonary artery endothelial cells and caspase 3/7 activity in both human pulmonary artery endothelial cells and human pulmonary artery smooth muscle cells. Compared with healthy controls, patients with PPS exhibited downregulated pulmonary artery endothelial prostaglandin I2 synthase levels and urinary prostaglandin I metabolite levels. We identified another PTGIS rare splice-site variant (c.1358+2T>C) in another pediatric patient with WS and severe PPS. CONCLUSIONS: In total, 2 rare nonsense/splice-site PTGIS variants were identified in 2 pediatric patients with WS and severe PPS. PTGIS variants may be involved in PPS pathogenesis, and PTGIS represents an effective therapeutic target.

小児がん治療後に続発がんを来した27例の特徴と経過 単施設報告　　　　　　　　　　　　　　　
村澤 玲奈, 足洗 美穂, 小野 林太郎, 吉原 宏樹, 細谷 要介, 真部 淳, 小澤 美和, 長谷川 大輔
日本小児科学会雑誌, 128, 2, 238, 238, (公社)日本小児科学会, Feb. 2024
Japanese

Pearson症候群に対する臍帯血移植後の長期経過　　　　　　　　　　　　　　　
村越 未希, 足洗 美穂, 村澤 玲奈, 梅原 直, 西村 聡, 小野 林太郎, 吉原 宏樹, 細谷 要介, 平林 真介, 真部 淳, 小澤 美和, 長谷川 大輔
日本小児科学会雑誌, 128, 2, 403, 403, (公社)日本小児科学会, Feb. 2024
Japanese

TBI, etoposide, and cyclophosphamide conditioning for intermediate-risk relapsed childhood acute lymphoblastic leukemia.
Hideaki Ueki, Chitose Ogawa, Hiroaki Goto, Masanori Nishi, Junko Yamanaka, Shinji Mochizuki, Takuro Nishikawa, Tadashi Kumamoto, Ritsuo Nishiuchi, Atsushi Kikuta, Shohei Yamamoto, Shunji Igarashi, Atsushi Sato, Toshinori Hori, Akiko M Saito, Tomoyuki Watanabe, Takao Deguchi, Atsushi Manabe, Keizo Horibe, Hidemi Toyoda
International journal of hematology, 25 Jan. 2024, [Domestic magazines]
English, Scientific journal, BACKGROUND: In children with intermediate-risk relapsed acute lymphoblastic leukemia (ALL), allogeneic hematopoietic stem cell transplantation (allo-HSCT) has markedly improved the outcome of patients with an unsatisfactory minimal residual disease (MRD) response. Total body irradiation (TBI), etoposide (ETP), and cyclophosphamide (CY) have been shown to be equivalent to or better than TBI + ETP for conditioning, so we hypothesized that even greater survival could be achieved due to recent advances in HSCT and supportive care. PROCEDURE: We prospectively analyzed the efficacy and safety of allo-HSCT with a unified conditioning regimen of TBI + ETP + CY in children with intermediate-risk relapsed ALL, based on MRD in the bone marrow after induction, from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) ALL-R08-II nationwide cohort (UMIN000002025). RESULTS: Twenty patients with post-induction MRD ≥ 10-3 and two not evaluated for MRD underwent allo-HSCT. Engraftment was confirmed in all patients, and no transplantation-related mortality was observed. The 3-year event-free survival and overall survival rates after transplantation were 86.4% ± 7.3% and 95.5% ± 4.4%, respectively. CONCLUSION: Allo-HSCT based on post-induction MRD with TBI + ETP + CY conditioning was feasible in Japanese children with intermediate-risk relapsed ALL.

Allogeneic Hematopoietic Cell Transplantation for Juvenile Myelomonocytic Leukemia with a Busulfan, Fludarabine, and Melphalan Regimen: JPLSG JMML-11.
Kazuo Sakashita, Nao Yoshida, Hideki Muramatsu, Yoshitoshi Ohtsuka, Kenichiro Watanabe, Miharu Yabe, Harumi Kakuda, Yuko Honda, Tomoyuki Watanabe, Masami Haba, Shigeru Ohmori, Kazuyuki Matsuda, Yuki Yuza, Akiko Saito, Keizo Horibe, Souichi Adachi, Atsushi Manabe
Transplantation and cellular therapy, 30, 1, 105.e1-105.e10, Jan. 2024, [International Magazine]
English, Scientific journal, Juvenile myelomonocytic leukemia (JMML), which is classified as a myelodysplastic/myeloproliferative neoplasm, is a rare hematologic malignancy of childhood. Most patients with JMML require allogeneic hematopoietic cell transplantation (HCT) as a curative therapy. A Japanese retrospective analysis demonstrated favorable outcomes for a busulfan (BU) + fludarabine (FLU) + melphalan (MEL) regimen, with an overall survival (OS) of 72% and an event-free survival (EFS) of 53%. To further validate the efficacy and safety of this regimen, the Japan Pediatric Leukemia/Lymphoma Study Group (JPLSG) conducted a nationwide prospective study, JMML-11. Between July 2011 and June 2017, 28 patients with newly diagnosed JMML were enrolled in JMML11. Low-dose chemotherapy for tumor control before HCT was recommended, and patients treated with AML-type chemotherapy and azacitidine were excluded. The conditioning regimen comprised i.v. BU, 16 doses administered every 6 h, with dose adjustment based on pharmacokinetic (PK) studies on days -11 to -8; FLU, 30 mg/m2/day or 1 mg/kg/day for patients <10 kg or age <1 year on days -7 to -4; and MEL, 90 mg/m2/day or 3 mg/kg/day for patients <10 kg or <1 year on days -3 to -2. The donor was selected by the physician in charge. A family donor was available for 7 patients (3 HLA-matched siblings, 3 HLA-1-antigen mismatched parents, and 1 haploidentical father). Overall, 21 patients received grafts from unrelated donors, including 8 HLA-matched donors and 13 HLA-mismatched donors. The graft source was related bone marrow (BM) for 7 patients, unrelated BM for 14 patients, and unrelated cord blood for 7 patients. Neutrophil engraftment was achieved in 21 of 28 patients (75%), with a median of 20.5 days (range, 11 to 39 days) after transplantation. The 3-year OS, 3-year EFS, 3-year relapse rate, and 3-year transplantation-related mortality were 63% (95% confidence interval [CI], 42% to 78%), 52% (95% CI, 32% to 69%), 18% (95% CI, 6% to 34%), and 21% (95% CI, 9% to 38%), respectively. WBC count before the conditioning regimen (≥7.0 × 109/L) was significantly associated with inferior EFS and OS. Body surface area ≥.5 m2, spleen size <4 cm before conditioning, and HLA-matched unrelated BM donors were significantly associated with better OS. Adverse effects related to the conditioning regimen included febrile neutropenia (86%), diarrhea (39%), hypoxemia (21%), and mucositis (18%). BU-associated toxicity, including sinusoidal obstruction syndrome (SOS) and thrombotic microangiopathy (TMA), occurred in 7 patients (25%; SOS, n = 6; TMA, n = 2). Retrospective analysis of PK data after the first BU dose in 23 patients, including 6 with SOS and 17 without SOS, did not show significant differences between groups. The JMML-11 study confirms the positive results of previous retrospective analyses. BU+FLU+MEL might become a standard conditioning regimen for patients with JMML.

Nusinersen induces detectable changes in compound motor action potential response in spinal muscular atrophy type 1 patients with severe impairment of motor function.
Yuki Ueda, Kiyoshi Egawa, Kentaro Kawamura, Noriki Ochi, Takeru Goto, Shuhei Kimura, Masashi Narugami, Sachiko Nakakubo, Midori Nakajima, Atsushi Manabe, Hideaki Shiraishi
Brain & development, 15 Dec. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: Most long-term affected spinal muscular atrophy (SMA) type 1 patients have severe impairment of motor function and are dependent on mechanical ventilation with tracheostomy. The efficacy and safety of nusinersen in these patients have not been established. METHODS: We retrospectively evaluated the efficacy of intrathecal nusinersen treatment in patients with SMA type 1 who continued treatment for at least 12 months. There were three patients enrolled in our study (3, 4 and 16 years of age) who had severe impairment of gross motor function without head control or the ability to roll over. All three needed mechanical ventilation with tracheostomy and tube feeding. Motor function was assessed using the Children s Hospital of Philadelphia infant test of neuromuscular disorders (CHOP-INTEND) and the caregivers' evaluations. Concurrently, we examined nerve conduction longitudinally and compared compound motor action potential (CMAP) amplitudes. RESULTS: All patients continued nusinersen administration without significant adverse events for more than three years. While CHOP-INTEND scores did not remarkably increase, according to the caregivers, all three patients had improved finger or facial muscle movements that enabled them to make their intentions understood. Some CMAPs before treatment were not identified but became traces after nusinersen administration. CONCLUSIONS: The improvement in motor function that leads to smoother communication could be a basis for continuing nusinersen treatment. Currently available motor function scorings are not efficient for assessing therapeutic interventions in SMA patients with medical care complexity. Longitudinal nerve conduction studies could be an objective indicator.

Biologic and clinical features of childhood gamma delta T-ALL: identification of STAG2/LMO2 γδ T-ALL as an extremely high risk leukemia in the very young.
Shunsuke Kimura, Petri Polonen, Lindsey Montefiori, Chun Shik Park, Ilaria Iacobucci, Allen Ej Yeoh, Andishe Attarbaschi, Andrew S Moore, Anthony Brown, Atsushi Manabe, Barbara Buldini, Burgess B Freeman, Chelsey Chen, Cheng Cheng, Chiew Kean Hui, Chi-Kong Li, Ching-Hon Pui, Chunxu Qu, Daisuke Tomizawa, David T Teachey, Elena Varotto, Elisabeth M Paietta, Elizabeth D Arnold, Franco Locatelli, Gabriele Escherich, Hannah Elisa Muhle, Hanne Vibeke Marquart, Hester A de Groot-Kruseman, Jacob M Rowe, Jan Stary, Jan Trka, John Kim Choi, Jules P P Meijerink, Jun J Yang, Junko Takita, Katarzyna Pawinska-Wasikowska, Kathryn G Roberts, Katie Han, Kenneth J Caldwell, Kjeld Schmiegelow, Kristine R Crews, Mariko Eguchi, Martin Schrappe, Martin Zimmerman, Masatoshi Takagi, Mellissa Maybury, Michael Svaton, Michaela Reiterova, Michal Kicinski, Mollie S Prater, Motohiro Kato, Noemi Reyes, Orietta Spinelli, Paul Thomas, Pauline Mazilier, Qingsong Gao, Riccardo Masetti, Rishi S Kotecha, Rob Pieters, Sarah Elitzur, Selina M Luger, Sharnise Mitchell, Shondra M Pruett-Miller, Shuhong Shen, Sima Jeha, Stefan Köhrer, Steven M Kornblau, Szymon Skoczeń, Takako Miyamura, Tiffaney L Vincent, Toshihiko Imamura, Valentino Conter, Yanjing Tang, Yen-Chun Liu, Yunchao Chang, Zhaohui Gu, Zhongshan Cheng, Zhou Yinmei, Hiroto Inaba, Charles G Mullighan
medRxiv : the preprint server for health sciences, 08 Nov. 2023, [International Magazine]
English, PURPOSE: Gamma delta T-cell receptor-positive acute lymphoblastic leukemia (γδ T-ALL) is a high-risk but poorly characterized disease. METHODS: We studied clinical features of 200 pediatric γδ T-ALL, and compared the prognosis of 93 cases to 1,067 protocol-matched non-γδ T-ALL. Genomic features were defined by transcriptome and genome sequencing. Experimental modeling was used to examine the mechanistic impacts of genomic alterations. Therapeutic vulnerabilities were identified by high throughput drug screening of cell lines and xenografts. RESULTS: γδ T-ALL in children under three was extremely high-risk with 5-year event-free survival (33% v. 70% [age 3-<10] and 73% [age ≥10], P =9.5 x 10 -5 ) and 5-year overall survival (49% v. 78% [age 3-<10] and 81% [age ≥10], P =0.002), differences not observed in non-γδ T-ALL. γδ T-ALL in this age group was enriched for genomic alterations activating LMO2 activation and inactivating STAG2 inactivation ( STAG2/LMO2 ). Mechanistically, we show that inactivation of STAG2 profoundly perturbs chromatin organization by altering enhancer-promoter looping resulting in deregulation of gene expression associated with T-cell differentiation. Drug screening showed resistance to prednisolone, consistent with clinical slow treatment response, but identified a vulnerability in DNA repair pathways arising from STAG2 inactivation, which was efficaciously targeted by Poly(ADP-ribose) polymerase (PARP) inhibition, with synergism with HDAC inhibitors. Ex-vivo drug screening on PDX cells validated the efficacy of PARP inhibitors as well as other potential targets including nelarabine. CONCLUSION: γδ T-ALL in children under the age of three is extremely high-risk and enriched for STAG2/LMO2 ALL. STAG2 loss perturbs chromatin conformation and differentiation, and STAG2/LMO2 ALL is sensitive to PARP inhibition. These data provide a diagnostic and therapeutic framework for pediatric γδ T-ALL. SUPPORT: The authors are supported by the American and Lebanese Syrian Associated Charities of St Jude Children's Research Hospital, NCI grants R35 CA197695, P50 CA021765 (C.G.M.), the Henry Schueler 41&9 Foundation (C.G.M.), and a St. Baldrick's Foundation Robert J. Arceci Innovation Award (C.G.M.), Gabriella Miller Kids First X01HD100702 (D.T.T and C.G.M.) and R03CA256550 (D.T.T. and C.G.M.), F32 5F32CA254140 (L.M.), and a Garwood Postdoctoral Fellowship of the Hematological Malignancies Program of the St Jude Children's Research Hospital Comprehensive Cancer Center (S.K.). This project was supported by the National Cancer Institute of the National Institutes of Health under the following award numbers: U10CA180820, UG1CA189859, U24CA114766, U10CA180899, U10CA180866 and U24CA196173. DISCLAIMER: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funding agencies were not directly involved in the design of the study, gathering, analysis and interpretation of the data, writing of the manuscript, or decision to submit the manuscript for publication.

長期フォローアップレベルと晩期合併症の関連 聖路加生涯コホート研究より　　　　　　　　　　　　　　　
鈴木 優里, 永瀬 恭子, 郡司 美千代, 小林 京子, 細谷 要介, 長谷川 大輔, 石田 也寸志, 真部 淳, 小澤 美和
日本小児血液・がん学会雑誌, 60, 4, 366, 366, (一社)日本小児血液・がん学会, Nov. 2023
Japanese

Use of lacosamide for focal epilepsy in a child with kidney failure undergoing peritoneal dialysis.
Yuki Ueda, Ayako Furugen, Masaki Kobayashi, Yasuyuki Sato, Yasuhiro Ueda, Asako Hayashi, Takeru Goto, Shuhei Kimura, Masashi Narugami, Sachiko Nakakubo, Midori Nakajima, Kiyoshi Egawa, Takayuki Okamoto, Atsushi Manabe, Hideaki Shiraishi
Brain & development, 30 Oct. 2023, [International Magazine]
English, BACKGROUND: Lacosamide (LCM) has become commonly used for focal onset seizures due to its high tolerability and low drug interactions. Unlike patients on hemodialysis (HD), pharmacokinetic data and dosing recommendations for patients undergoing peritoneal dialysis (PD) are scant. CASE REPORT: A 2-year-old girl with end-stage kidney disease undergoing PD suffered prolonged focal onset seizures. The patient had congenital anomalies of the kidney and urinary tract associated with branchio-oto-renal syndrome due to an EYA1 gene mutation. She also had neurological sequelae from post-resuscitation encephalopathy at the age of one month. Antiseizure medication with few drug interactions, less impact on the neurodevelopmental state and possibility of intravenous administration was preferred. LCM met those criteria and was carefully administered. Although the patient had recurrent prolonged seizures during the titration periods, LCM could be continued without any apparent side effects. The blood levels of LCM increased linearly to the optimal level. We confirmed excretion of LCM in the PD fluid. Kidney transplantation was done three months after and her seizures were well controlled. CONCLUSIONS: LCM might be a promising option for patients undergoing PD. Due to the lower removal efficacy in PD compared with in HD, close attention should be paid to possible drug excess.

Genome-wide assessment of genetic risk loci for childhood acute lymphoblastic leukemia in Japanese patients.
Mayumi Hangai, Takahisa Kawaguchi, Masatoshi Takagi, Keitaro Matsuo, Soyoung Jeon, Charleston W K Chiang, Andrew T Dewan, Adam J De Smith, Toshihiko Imamura, Yasuhiro Okamoto, Akiko M Saito, Takao Deguchi, Michiaki Kubo, Yoichi Tanaka, Yoko Ayukawa, Toshinari Hori, Kentaro Ohki, Nobutaka Kiyokawa, Takeshi Inukai, Yuki Arakawa, Makiko Mori, Daisuke Hasegawa, Daisuke Tomizawa, Hiroko Fukushima, Yuki Yuza, Yasushi Noguchi, Yuichi Taneyama, Setsuo Ota, Hiroaki Goto, Masakatsu Yanagimachi, Dai Keino, Kazutoshi Koike, Daisuke Toyama, Yozo Nakazawa, Kozue Nakamura, Koichi Moriwaki, Yujin Sekinaka, Daisuke Morita, Shinsuke Hirabayashi, Yosuke Hosoya, Yuri Yoshimoto, Hiroki Yoshihara, Miwa Ozawa, Shinobu Kobayashi, Naho Morisaki, Tshewang Gyeltshen, Osamu Takahashi, Yukinori Okada, Makiko Matsuda, Toshihiro Tanaka, Johji Inazawa, Junko Takita, Yasushi Ishida, Akira Ohara, Catherine Metayer, Joseph L Wiemels, Xiaomei Ma, Shuki Mizutani, Katsuyoshi Koh, Yukihide Momozawa, Keizo Horibe, Fumihiko Matsuda, Motohiro Kato, Atsushi Manabe, Kevin Y Urayama
Haematologica, 26 Oct. 2023, [International Magazine]
English, Scientific journal, Not available.

Prenatal metal concentrations and physical abnormalities in the Japan Environment and Children's Study.
Yuichi Nakamura, Sumitaka Kobayashi, Kazutoshi Cho, Sachiko Itoh, Chihiro Miyashita, Takeshi Yamaguchi, Hiroyoshi Iwata, Naomi Tamura, Yasuaki Saijo, Yoshiya Ito, Yoshitaka Seto, Ryota Honjo, Akiko Ando, Yuta Furuse, Atsushi Manabe, Reiko Kishi
Pediatric research, 19 Oct. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: The association between prenatal metal exposure and congenital anomalies is unclear. We aimed to examine the association between exposure to cadmium, lead, mercury, selenium, and manganese and physical abnormalities. METHODS: Data from 89,887 pregnant women with singleton pregnancies who participated in the Japan Environment and Children's Study (JECS) were used. The correlation between maternal blood metal concentrations and physical abnormalities during the second or third trimester was investigated using logistic regression models. Physical anomalies included those observed at birth or at 1 month, primarily from ICD-10 Chapter 17, particularly congenital anomalies associated with environmental factors (e.g., hypospadias, cryptorchidism, cleft lip and palate, digestive tract atresia, congenital heart disease, and chromosomal abnormalities) and minor abnormalities. RESULTS: After adjusting for covariates, the OR (95% CIs) of physical abnormalities for a one-unit rise in Mn concentrations in all individuals were 1.26 (1.08, 1.48). The OR (95% CIs) of physical abnormalities in the 4th quartile (≥18.7 ng/g) were 1.06 (1.01, 1.13) (p-value for the trend = 0.034) compared with those in the 1st quartile (≤12.5 ng/g). CONCLUSION: In Japan, maternal blood Mn concentrations above threshold during pregnancy may slightly increase the incidence of physical abnormalities. IMPACT: Physical abnormalities (including minor anomalies and congenital anomalies) are associated with prenatal manganese concentrations. They are not associated with cadmium, lead, mercury, and selenium concentrations.

Slow-growing WNT medulloblastoma with atypical magnetic resonance imaging findings: illustrative case.
Makoto Mizushima, Michinari Okamoto, Shigeru Yamaguchi, Sogo Oki, Hiroaki Motegi, Minako Sugiyama, Atsushi Manabe, Ai Shimizu, Kentaro Nishioka, Takayuki Hashimoto, Junko Hirato, Yonehiro Kanemura, Miki Fujimura
Journal of neurosurgery. Case lessons, 6, 7, 14 Aug. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: Medulloblastomas, with four molecular subgroups, are generally rapid-growing tumors with significant contrast enhancement and well-defined margins. However, each subgroup's clinical features, including disease time course and imaging characteristics, are not well defined. OBSERVATIONS: The authors describe the case of a 15-year-old female who presented with a 7-month history of impaired left-hand movement and was found to have a lesion on the dorsal side of the fourth ventricle. T2-weighted magnetic resonance imaging (MRI) at the patient's first presentation showed diffuse hyperintense signal without apparent mass, and gadolinium-enhanced T1-weighted imaging showed very slight contrast enhancement. In 1 month, her symptoms progressed, and follow-up MRI revealed an increase in the size of the lesion, showing greater diffusion restriction and contrast enhancement. She underwent gross-total resection, and pathology was consistent with classic medulloblastoma. Genetic analysis of the tumor confirmed the wingless (WNT) molecular subgroup. Adjuvant chemotherapy and proton beam therapy were performed. At the 18-month follow-up, MRI showed no recurrence of disease. LESSONS: Slow-growing medulloblastoma is very rare and not known to be associated with a specific molecular subgroup. Here, the authors report a case of slow-growing WNT medulloblastoma, indicating that slow growth may be a feature of this subgroup.

Challenges to Widespread Use of Fertility Preservation Facilities for Pediatric Cancer Patients in Japan.
Tadashi Maezawa, Nao Suzuki, Hiroki Takeuchi, Mikiko Nishioka, Moe Hidaka, Atsushi Manabe, Yuhki Koga, Hiroshi Kawaguchi, Yoji Sasahara, Masahito Tachibana, Shotaro Iwamoto, Akihito Horie, Hidefumi Hiramatsu, Motohiro Kato, Miyuki Harada, Yuki Yuza, Masahiro Hirayama, Junko Takita, Tomoaki Ikeda, Kimikazu Matsumoto
Journal of adolescent and young adult oncology, 03 Aug. 2023, [International Magazine]
English, Scientific journal, Purpose: Although fertility preservation for pediatric cancer patients is becoming more widespread in Japan, some facilities do not provide sufficient information regarding fertility. This study aimed to elucidate the problems pertaining to the lack of information about fertility among patients. Methods: Based on a 2020 survey, seminars addressing fertility preservation were held from the Designated Pediatric Cancer Care Hospitals in each of the seven blocks in Japan to their partner hospital (pediatric cancer hospitals). The seminar consisted of lectures and group discussions, and a questionnaire was also administered after each seminar. Results: In the group discussions, a lack of explanations to patients and explanatory materials for children were cited as issues by many facilities. The survey results revealed a lack of material explaining fertility preservation and a lack of knowledge among health care providers. There were also many requests to use the patient explanation videos presented at the seminar. Conclusion: The results indicate that further education for health care providers by seminar and other sources and enhancement of explanatory materials are important for fertility preservation in pediatric cancer hospitals in Japan.

Therapeutic Drug Monitoring of Oral Voriconazole in an Infant Less than Six Months of Age and Pharmacokinetics Changes Induced by Development of CYP2C19 in the Growth Process: A Novel Case Report
Atsushi Yamaguchi, Yuki Tazawa, Masashiro Ueki, Masafumi Yamada, Atsushi Manabe, Mitsuru Sugawara, Yoh Takekuma
YAKUGAKU ZASSHI, 143, 6, 545, 549, Pharmaceutical Society of Japan, 01 Jun. 2023, [Peer-reviewed]
Scientific journal

Efficacy of sirolimus for epileptic seizures in childhood associated with focal cortical dysplasia type II
Hideaki Shiraishi, Tsuyoshi Teramoto, Saki Yokoshiki, Jun Tohyama, Yuki Ueda, Kiyoshi Egawa, Norihiro Sato, Atsushi Manabe, Mitsuhiro Kato
BRAIN & DEVELOPMENT, 45, 6, 343, 347, Jun. 2023
English, Scientific journal

ブスルファンの著しい薬物動態変動が認められた小児の1例
山口 敦史, 武隈 洋, 仁木 加寿子, 平林 真介, 寺下 友佳代, 長谷河 昌孝, 長 祐子, 真部 淳, 菅原 満
TDM研究, 40, 2, 212, 212, (一社)日本TDM学会, Jun. 2023
Japanese

Rare TCF3 variants associated with pediatric B cell acute lymphoblastic leukemia.
Satoshi Miyamoto, Kevin Y Urayama, Yuki Arakawa, Katsuyoshi Koh, Yuki Yuza, Daisuke Hasegawa, Yuichi Taneyama, Yasushi Noguchi, Masakatsu Yanagimachi, Takeshi Inukai, Setsuo Ota, Hiroyuki Takahashi, Dai Keino, Daisuke Toyama, Junko Takita, Daisuke Tomizawa, Tomohiro Morio, Kazutoshi Koike, Koichi Moriwaki, Yuya Sato, Junya Fujimura, Daisuke Morita, Yujin Sekinaka, Kozue Nakamura, Kazuo Sakashita, Hiroaki Goto, Atsushi Manabe, Masatoshi Takagi
Pediatric hematology and oncology, 1, 7, 02 May 2023, [International Magazine]
English, Scientific journal, Germline genetic variants influence development of pediatric B cell acute lymphoblastic leukemia (B-ALL). Genome-wide association studies (GWAS) have identified several pediatric B-ALL susceptibility loci. IKZF1 and PAX5, transcription factors involved in B cell development, have been reported as susceptibility genes for B-ALL development. Therefore, we hypothesized that rare variants of genes involved in B cell development would be candidate susceptibility loci for pediatric B-ALL. Thus, we sequenced TCF3, a key transcription factor gene involving in B cell development. Saliva DNA from 527 pediatric patients with pediatric B-ALL in remission who were registered with the Tokyo Children's Cancer Study Group (TCCSG) were examined. As a TCF3 gene-based evaluation, the numbers of rare deleterious germline TCF3 sequence variants in patients with pediatric B-ALL were compared with those in cancer-free individuals using data in public databases. As a TCF3 single-variant evaluation, the frequencies of rare deleterious germline TCF3 sequence variants in patients with pediatric B-ALL were also compared with those in control data. TCF3 gene-based analysis revealed significant associations between rare deleterious variants and pediatric B-ALL development. In addition, TCF3 variant-based analysis showed particularly strong association between variant rs372168347 (three in 521 TCCSG and three in the 15780 gnomAD whole genome analysis cohort, p = 0.0006) and pediatric B-ALL development. TCF3 variants are known to influence B cell maturation and may increase the risk of preleukemic clone emergence.

Gタンパク共役型受容体101(GPR101)遺伝子変異を同定した複合型下垂体機能低下症の兄弟例
森川 俊太郎, 金子 直哉, 中山 加奈子, 菱村 希, 山口 健史, 佐々木 大輔, 上田 泰弘, 渡邊 さやか, 青柳 勇人, 中村 明枝, 真部 淳
日本内分泌学会雑誌, 99, 1, 311, 311, (一社)日本内分泌学会, May 2023
Japanese

北海道の小児医療体制を支える広域搬送システムの有用性
武田 充人, 真部 淳
小児保健研究, 82, 講演集, 133, 133, (公社)日本小児保健協会, May 2023
Japanese

Changes in bone turnover markers after discontinuing long-term glucocorticoid administration in children with idiopathic nephrotic syndrome: a multicenter retrospective observational study.
Yasuhiro Ueda, Takayuki Okamoto, Yasuyuki Sato, Asako Hayashi, Toshiyuki Takahashi, Ryota Suzuki, Aoyagi H, MICHIHIKO UENO, Kobayashi N, Uetake K, Nakanishi M, Ariga T, Atsushi Manabe
Pediatric nephrology (Berlin, Germany), 13 Apr. 2023, [Peer-reviewed]
Scientific journal,

Background

Glucocorticoids affect bone turnover. Little is known about how bone turnover changes when glucocorticoids are discontinued following long-term administration.

Methods

This retrospective observational study was conducted on the relationship between discontinuation of long-term administration of glucocorticoid and bone turnover markers (BTMs) in patients with childhood-onset idiopathic nephrotic syndrome. Serum bone alkaline phosphatase (BAP), intact procollagen type 1 N-terminal propeptide (P1NP), and tartrate-resistant acid phosphatase-5b (TRACP-5b) were evaluated as BTMs.

Results

Thirty-eight pairs of BTMs at glucocorticoid administration and after discontinuation were analyzed in 29 patients. The median age at baseline was 12.4 (interquartile range, 9.0-14.5) years, and the median time from the onset of nephrotic syndrome was 5.9 (3.3-9.7) years. The mean period from prednisolone discontinuation to the measurement of BTMs after glucocorticoid discontinuation was 3.5 ± 1.0 months. Changes in BTMs after glucocorticoid discontinuation were modest when the daily prednisolone dose was < 0.25 mg/kg/day (ln BAP standard deviation [SD] score, p = 0.19; log intact P1NP SD score, p = 0.70; TRACP-5b, p = 0.95). When the daily prednisolone dose was ≥ 0.25 mg/kg/day, all BTMs increased significantly after glucocorticoid discontinuation (ln BAP SD score, p < 0.01; log intact P1NP SD score, p < 0.01; TRACP-5b, p < 0.01).

Conclusions

Decreased BTMs can rise within a few months of discontinuing long-term glucocorticoid administration. When the administered glucocorticoid dose is low, changes in BTMs may be small. A higher resolution version of the Graphical abstract is available as Supplementary information.

Outcomes following induction failure in Japanese children with acute lymphoblastic leukemia.
Chihaya Imai, Atsushi Sato, Mitsuteru Hiwatari, Yasuto Shimomura, Toshinori Hori, Souichi Suenobu, Toshihiko Imamura, Junichi Hara, Daisuke Hasegawa, Hiroyuki Takahashi, Kunihiko Moriya, Saori Katayama, Daisuke Tomizawa, Hiroshi Moritake, Takashi Taga, Keizo Horibe, Katsuyoshi Koh, Atsushi Manabe, Yasuhiro Okamoto
International journal of hematology, 118, 1, 99, 106, 10 Apr. 2023, [Domestic magazines]
English, Scientific journal, The characteristics and prognosis of Japanese children with acute lymphoblastic leukemia (ALL) who fail to achieve complete remission after remission induction chemotherapy (i.e., experience induction failure) are poorly understood. Therefore, we retrospectively analyzed data of patients enrolled in Japanese clinical trials for newly diagnosed ALL between 1996 and 2009. Among 4956 participants, 89 (1.8%) experienced induction failure. With a 6.0-year median follow-up, the 5-year overall survival rate of the entire cohort was 43.0% ± 5.5%. Survival rates did not differ between patients with B-cell precursor ALL (BCP-ALL) and T-cell ALL (T-ALL). In multivariate analysis, day 15 M3 marrow (bone marrow blast count ≥ 25%) was significantly correlated with poorer survival in the whole or BCP-ALL cohorts. In T-ALL, age < 6 years was significantly associated with poor survival. However, due to the small sample size, this correlation must be further investigated. Most T-ALL and BCR-ABL-positive BCP-ALL patients underwent allogeneic stem cell transplantation (allo-SCT). Survival rates did not differ between BCR-ABL-negative BCP-ALL patients who did and did not undergo allo-SCT, possibly due to the inclusion of lower-risk patients in the latter group. In conclusion, the induction failure rate and survival after diagnosis of induction failure in our study were comparable to previously reported figures.

前思春期のビスフェノール類曝露と性・ステロイドホルモン値との関連 北海道スタディ
池田 敦子, 山口 健史, アイツバマイ ゆふ, 池中 良徳, ケテマ・ラヘルメスフィ, 曾 怡, 中村 明枝, 橘田 岳也, 今 雅史, 篠原 信雄, 真部 淳, 宮下 ちひろ, コバチ・アドリアン, 岸 玲子
日本衛生学雑誌, 78, Suppl., S181, S181, (一社)日本衛生学会, Mar. 2023
Japanese

高用量ステロイド吸入により医原性グルココルチコイド過剰および二次性副腎皮質機能不全をきたした女児例
小野 夏実, 金子 直哉, 中山 加奈子, 菱村 希, 山口 健史, 森川 俊太郎, 真部 淳, 中村 明枝
臨床小児医学, 70, 1-6, 57, 63, (財)小児愛育協会, Mar. 2023
Japanese

Sunburst appearanceを呈する頭蓋骨腫瘤を契機に発見された神経芽腫の1例　　　　　　　　　　　　　　　
北川 悠, 竹中 淳規, 渡邊 史郎, 平田 健司, 内山 裕子, 木村 理奈, 中川 純一, 池辺 洋平, 長谷河 昌孝, 澤井 彩織, 寺下 友佳代, 杉山 未奈子, 平林 真介, 長 祐子, 山口 秀, 真部 淳, 工藤 與亮
北海道放射線医学雑誌, 3, 33, 36, (NPO)メディカルイメージラボ, Mar. 2023
Japanese

小児がん経験者(CCS)フォロー中に甲状腺がんを発症した4例
金子 直哉, 菱村 希, 寺下 友佳代, 中山 加奈子, 山口 健史, 森川 俊太郎, 長谷河 昌孝, 澤井 彩織, 杉山 未奈子, 平林 真介, 長 祐子, 真部 淳, 中村 明枝
日本内分泌学会雑誌, 98, 4, 719, 719, (一社)日本内分泌学会, Feb. 2023
Japanese

A nationwide survey of late effects in survivors of juvenile myelomonocytic leukemia in Japan.
Shuichi Ozono, Kazuo Sakashita, Nao Yoshida, Harumi Kakuda, Kenichiro Watanabe, Miho Maeda, Yasushi Ishida, Atsushi Manabe, Takashi Taga, Hideki Muramatsu
Pediatric blood & cancer, 70, 2, e30126, Feb. 2023, [International Magazine]
English, Scientific journal, We conducted a cross-sectional study using a questionnaire to explore the late effects in survivors of allogenic hematopoietic stem cell transplantation (HSCT) for juvenile myelomonocytic leukemia (JMML). The attending pediatric hematologists/oncologists completed the questionnaires. Of the 30 survivors, approximately 83% showed more than one late effect. The identified late effects included endocrine, dental, skin, ophthalmologic, musculoskeletal, pulmonary, neurocognitive, and cardiovascular dysfunction. The prevalence of short stature, pulmonary, cardiovascular, and nephrological complications was significantly elevated among survivors who were 12 years or more lapsed after HSCT. Therefore, a multidisciplinary follow-up system for survivors of JMML is crucial.

Therapeutic effects of KRM-II-81, positive allosteric modulator for α2/3 subunit containing GABAA receptors, in a mouse model of Dravet syndrome.
Sachiko Nakakubo, Yasuyoshi Hiramatsu, Takeru Goto, Syuhei Kimura, Masashi Narugami, Midori Nakajima, Yuki Ueda, Hideaki Shiraishi, Atsushi Manabe, Dishary Sharmin, James M Cook, Kiyoshi Egawa
Frontiers in pharmacology, 14, 1273633, 1273633, 2023, [International Magazine]
English, Scientific journal, Introduction: Dravet syndrome (DS) is an intractable epilepsy syndrome concomitant with neurodevelopmental disorder that begins in infancy. DS is dominantly caused by mutations in the SCN1A gene, which encodes the α subunit of a voltage-gated Na channel. Pre-synaptic inhibitory dysfunction is regarded as the pathophysiological mechanism, but an effective strategy for ameliorating seizures and behavioral problems is still under development. Here, we evaluated the effects of KRM-II-81, a newly developed positive allosteric modulator for α 2/3 subunit containing GABAA receptors (α2/3-GABAAR) in a mice model of DS both in vivo and at the neuronal level. Methods: We used knock-in mice carrying a heterozygous, clinically relevant SCN1A mutation (background strain: C57BL/6 J) as a model of the DS (Scn1a WT/A1783V mice), knock-in mouse strain carrying a heterozygous, clinically relevant SCN1A mutation (A1783V). Seizure threshold and locomotor activity was evaluated by using the hyperthermia-induced seizure paradigm and open filed test, respectively. Anxiety-like behavior was assessed by avoidance of the center region in locomotor activity. We estimated a sedative effect by the total distance traveled in locomotor activity and grip strength. Inhibitory post synaptic currents (IPSCs) were recorded from a hippocampal CA1 pyramidal neuron in an acutely prepared brain slice. Results: KRM-II-81 significantly increased the seizure threshold of Scn1a WT/A1783V mice in a dose-dependent manner. A low dose of KRM-II-81 specifically improved anxiety-like behavior of Scn1a WT/A1783V mice. A sedative effect was induced by relatively high dose of KRM-II-81 in Scn1a WT/A1783V mice, the dose of which was not sedative for WT mice. KRM-II-81 potentiated IPSCs by increasing its decay time kinetics. This effect was more prominent in Scn1a WT/A1783V mice. Discussion: Higher activation of α2/3-GABAAR by KRM-II-81 suggests a compensatory modification of post synaptic inhibitory function against presynaptic inhibitory dysfunction in Scn1a WT/A1783V. The increased sensitivity for KRM-II-81 may be relevant to the distinct dose-dependent effect in each paradigm of Scn1a WT/A1783V mice. Conclusion: Selective activation for α2/3-GABAAR by KRM-II-81 could be potential therapeutic strategy for treating seizures and behavioral problems in DS.

The heterozygous NUDT15 variant is not associated with the severity of 6-mercaptopurine-related side effects in early intensification therapy for childhood acute lymphoblastic leukemia
Jimei Zhao, Masahiro Ueki, Saori Sawai, Minako Sugiyama, Yukayo Terashita, Shinsuke Hirabayashi, Yuko Cho, Ryoji Kobayashi, Yoichi Tanaka, Atsushi Manabe
EJC Paediatric Oncology, 1, 100006, 100006, Elsevier BV, 2023
Scientific journal

Preterm toddlers have low nighttime sleep quality and high daytime activity.
Yoko Asaka, Yusuke Mitani, Hidenobu Ohta, Takayo Nakazawa, Rika Fukutomi, Kyoko Kobayashi, Mayuko Kumagai, Hitomi Shinohara, Michiko Yoshida, Akiko Ando, Yuko Yoshimura, Machiko Nakagawa, Yoshihisa Oishi, Masato Mizushima, Hiroyuki Adachi, Yosuke Kaneshi, Keita Morioka, Yoshitaka Seto, Rinshu Shimabukuro, Michio Hirata, Takashi Ikeda, Miwa Ozawa, Masahiro Takeshima, Atsushi Manabe, Tsutomu Takahashi, Kazuo Mishima, Mitsuru Kikuchi, Hitoshi Yoda, Isao Kusakawa, Kazutoshi Cho
Scientific reports, 12, 1, 20032, 20032, 21 Nov. 2022, [International Magazine]
English, Scientific journal, A number of studies have been made on the sleep characteristics of children born preterm in an attempt to develop methods to address the sleep problems commonly observed among such children. However, the reported sleep characteristics from these studies vary depending on the observation methods used, i.e., actigraphy, polysomnography and questionnaire. In the current study, to obtain reliable data on the sleep characteristics of preterm-born children, we investigated the difference in sleep properties between 97 preterm and 97 term toddlers of approximately 1.5 years of age using actigraphy. Actigraphy units were attached to the toddlers' waists with an adjustable elastic belt for 7 consecutive days, and a child sleep diary was completed by their parents. In the study, we found that preterm toddlers had more nocturnal awakenings and more daytime activity, suggesting that preterm-born children may have a different process of sleep development in their early development.

Clinical characteristics and outcomes of B-cell precursor ALL with MEF2D rearrangements: a retrospective study by the Ponte di Legno Childhood ALL Working Group.
Kentaro Ohki, Ellie R Butler, Nobutaka Kiyokawa, Shinsuke Hirabayashi, Anke K Bergmann, Anja Möricke, Judith M Boer, Hélène Cavé, Giovanni Cazzaniga, Allen Eng Juh Yeoh, Masashi Sanada, Toshihiko Imamura, Hiroto Inaba, Charles G Mullighan, Mignon L Loh, Ulrika Norén-Nyström, Lee-Yung Shih, Marketa Zaliova, Ching-Hon Pui, Oskar A Haas, Christine J Harrison, Anthony V Moorman, Atsushi Manabe
Leukemia, 29 Oct. 2022, [International Magazine]
English, Scientific journal

Long-term consequences of residual lesions after chemoradiotherapy in patients with germinoma at onset.
Shigeru Yamaguchi, Michinari Okamoto, Yukitomo Ishi, Ryosuke Sawaya, Hiroaki Motegi, Minako Sugiyama, Taisuke Harada, Noriyuki Fujima, Takashi Mori, Takayuki Hashimoto, Emi Takakuwa, Atsushi Manabe, Kohsuke Kudo, Hidefumi Aoyama, Miki Fujimura
Journal of neurosurgery. Pediatrics, 1, 8, 09 Sep. 2022, [International Magazine]
English, Scientific journal, OBJECTIVE: In patients with intracranial germ cell tumors, residual lesions are sometimes observed after completion of primary chemoradiotherapy. Although salvage resection of these end-of-treatment residual lesions is recommended for patients with nongerminomatous germ cell tumors, the necessity of early salvage resection for those with germinoma is not clear. The aim of this study was to investigate the frequency of residual germinoma lesions after primary chemoradiotherapy, as well as their management, long-term consequences, and prognosis. METHODS: The authors retrospectively reviewed patients who were primarily treated for germinoma between 2002 and 2021. Residual lesions were evaluated with MRI with and without contrast enhancement within 2 weeks after chemoradiotherapy. The decision to perform salvage resection of residual lesions was at the discretion of the treating physicians. The change in appearance of residual lesions was assessed with serial MRI. Overall survival (OS), progression-free survival (PFS), and recurrence pattern were also investigated. RESULTS: Sixty-nine patients were treated with chemoradiotherapy for germinoma, with a mean follow-up period of 108 months. Residual lesions were radiologically observed in 30 patients (43.5%). Among these, 5 patients (3 with pineal lesions and 2 with basal ganglia lesions) underwent salvage resection. Pathological examination revealed teratomatous components in 3 patients, whereas no tumoral components were identified in 2 patients. One patient with a basal ganglia lesion showed worsening of hemiparesis postoperatively. The remaining 25 patients received watchful observation without surgical intervention. Chronological periodic radiological change in residual lesions was evaluated in 21 patients. One year after primary treatment, the size of the residual lesions was stable and had decreased in 10 and 11 patients, respectively. None of the lesions increased in size. The 10-year PFS and OS rates were 96.7% and 97.3% in patients without residual lesions (n = 39), and 87.1% and 100% in patients with residual lesions (n = 30), respectively. Presence of residual lesions had no significant effect on PFS or OS. All recurrences occurred at distant sites or via dissemination without progression of the primary tumor site, regardless of the presence of residual lesion. CONCLUSIONS: End-of-treatment residual lesions are not rare in patients with germinoma, and these residual lesions seldom show progression. Because of the potential risk of surgical complications, the indication for early salvage surgery for residual lesions should be carefully determined. Watchful observation is recommended for the majority of these cases.

Prominence of NUDT15 genetic variation associated with 6‐mercaptopurine tolerance in a genome‐wide association study of Japanese children with acute lymphoblastic leukaemia
Yoichi Tanaka, Kevin Y. Urayama, Makiko Mori, Yuki Arakawa, Daisuke Hasegawa, Yasushi Noguchi, Masakatsu Yanagimachi, Dai Keino, Setsuo Ota, Koshi Akahane, Takeshi Inukai, Mayumi Hangai, Takahisa Kawaguchi, Masatoshi Takagi, Katsuyoshi Koh, Fumihiko Matsuda, Atsushi Manabe
British Journal of Haematology, 199, 2, 260, 269, Wiley, 12 Aug. 2022
Scientific journal

腹膜透析中に発症した焦点性てんかんに対してラコサミドを導入した小児例の経験　　　　　　　　　　　　　　　
植田 佑樹, 佐藤 泰征, 林 麻子, 上田 泰弘, 木村 修平, 後藤 健, 中久保 佐千子, 中島 翠, 江川 潔, 岡本 孝之, 白石 秀明, 古堅 彩子, 小林 正紀, 真部 淳
てんかん研究, 40, 2, 467, 467, (一社)日本てんかん学会, Aug. 2022
Japanese

北海道における成人先天性心疾患の移行医療からみえてくるもの
武田 充人, 山澤 弘州, 泉 岳, 佐々木 大輔, 永井 礼子, 辻岡 孝郎, 真部 淳
小児保健研究, 81, 講演集, 134, 134, (公社)日本小児保健協会, May 2022
Japanese

A retrospective analysis of azacitidine treatment for juvenile myelomonocytic leukemia.
Yuko Honda, Hideki Muramatsu, Yuka Nanjo, Shinsuke Hirabayashi, Toru Meguro, Nao Yoshida, Harumi Kakuda, Shuichi Ozono, Manabu Wakamatsu, Hiroshi Moritake, Masahiro Yasui, Hideki Sano, Atsushi Manabe, Kazuo Sakashita
International journal of hematology, 115, 2, 263, 268, Feb. 2022, [Domestic magazines]
English, Scientific journal, Juvenile myelomonocytic leukemia (JMML) is a pediatric hematological malignancy with a poor prognosis. Although several case series have been published describing hematological and molecular responses to azacitidine (AZA) treatment in patients with JMML, the efficacy and safety profile of AZA is not well investigated, especially in Asian children and children undergoing hematopoietic stem cell transplantation (HSCT). We retrospectively analyzed 5 patients who received a total of 12 cycles (median 2 cycles) of AZA treatment in Japan. All five patients were boys and their ages at the time of treatment were 21, 23, 24, 26, and 46 months, respectively. All five patients tolerated AZA treatment, including four patients who received AZA after HSCT. Therapeutic toxicity with AZA was mostly limited to hematological toxicity. The only serious non-hematological adverse event was hyperbilirubinemia (grades III-IV) observed in a patient who received AZA after a second HSCT. Two out of five patients treated with AZA achieved a partial response (PR), while three patients treated for post-transplant relapse did not have an objective response. Future prospective studies should be conducted to develop combination therapies with AZA and other molecular targeted drugs for high-risk patients.

Prospective validation of the provisional entity of refractory cytopenia of childhood, proposed by the World Health Organization.
Asahito Hama, Daisuke Hasegawa, Atsushi Manabe, Kazue Nozawa, Atsushi Narita, Hideki Muramatsu, Yoshiyuki Kosaka, Masao Kobayashi, Katsuyoshi Koh, Yoshiyuki Takahashi, Kenichiro Watanabe, Akira Ohara, Masafumi Ito, Seiji Kojima
British journal of haematology, 196, 4, 1031, 1039, Feb. 2022, [International Magazine]
English, Scientific journal, In 2008, the World Health Organization proposed a new entity of childhood myelodysplastic syndrome (MDS), which was referred to as refractory cytopenia of childhood (RCC). However, whether this morphological classification reflects clinical outcomes remains unclear. We performed a prospective evaluation of bone marrow morphology in 252 children with acquired bone marrow failure between 2009 and 2013. Of 252 patients, 63 were diagnosed with aplastic anaemia (AA), 131 with RCC without multilineage dysplasia (RCC-w/o-MLD) and 58 with RCC with MLD (RCC-MLD). One patient with AA, three with RCC-w/o-MLD and nine with RCC-MLD presented with chromosomal abnormalities at diagnosis (P = 0·001). The response rates to immunosuppressive therapy (IST) at 6 months and the cumulative incidence of clonal evolution at 5 years did not significantly differ among the three groups. A multivariate analysis revealed that the morphological classification of RCC-MLD was a significant risk factor for secondary graft failure after haematopoietic cell transplantation (HCT) (P = 0·003). In view of these findings, RCC could be divided into two categories, RCC-w/o-MLD and RCC-MLD, because children with this condition exhibited a distinct morphology, frequent chromosomal abnormalities at diagnosis and a high frequency of secondary graft failure after HCT.

Factors related to employment in childhood cancer survivors in Japan: A preliminary study.
Kyoko Kobayashi, Yasushi Ishida, Michiyo Gunji, Kyoko Nagase, Yuri Yoshimoto-Suzuki, Yosuke Hosoya, Daisuke Hasegawa, Atsushi Manabe, Sachiko Ohde, Miwa Ozawa
Frontiers in pediatrics, 10, 961935, 961935, 2022, [International Magazine]
English, Scientific journal, PURPOSE: Previous research has revealed vocational and academic difficulties in childhood cancer survivors, and explored impact of survivors' medical history and physical function on vocational and academic status. However, we often encounter survivors with similar diagnoses and late effects but different academic or employment statuses. This raises the question of what affects academic attainment and employment other than treatment or late effects. This study aimed to explore factors associated with childhood cancer survivors' employment status and academic achievement. METHODS: Comprehensive health check-up and questionnaire survey were conducted for 69 survivors who were over the age of 18 and participated in St. Luke's Lifetime cohort study. We obtained survivors' biological function using comprehensive health check-up, neurocognitive states, quality of life, transition readiness, and family function. We conducted univariate analysis (Mann-Whitney U tests or chi-square tests) to compare the differences between the regular workers/students and non-regular workers/unemployed groups. The variables with p-values <0.1 were used as independent variables multivariate logistic regression to explore predictors of employment status and academic attainment. RESULTS: Result of the univariate analysis, intelligence quotient, SF-8 PCS, transition readiness, family function were used for multivariate logistic regression as independent variables. The stepwise likelihood method was conducted; intelligence quotient (odds ratio [OR] = 1.100; 95% confidence interval [CI] 1.015-1.193; p = 0.021), transition readiness (OR = 0.612; 95% CI 0.396-0.974; p = 0.038), and family function (OR = 2.337; 95% CI 1.175-4.645; p = 0.015) were found to be associated with survivors' regular workers/students in the final regression model. CONCLUSION: Long-term follow-up of pediatric cancer survivors requires the provision of total care, which supports physical, psychological, and social functions to improve health, readiness for transition to self-management, and family functioning.

Significance of active screening for detection of health problems in childhood cancer survivors.
Yuri Yoshimoto-Suzuki, Daisuke Hasegawa, Yosuke Hosoya, Go Saito, Kyoko Nagase, Michiyo Gunji, Kyoko Kobayashi, Yasushi Ishida, Atsushi Manabe, Miwa Ozawa
Frontiers in pediatrics, 10, 947646, 947646, 2022, [International Magazine]
English, Scientific journal, Background: Childhood cancer survivors (CCSs) have a lifelong increased risk of chronic health problems, most of which are associated with the curative therapies. Recent studies have suggested that prospective active screening using comprehensive assessments for CCSs is superior in identifying undiagnosed chronic health problems. Methods: To assess the significance of active screening using comprehensive medical examinations for detecting chronic health problems in multiple organ systems in CCSs, we retrospectively compared the frequency and severity of health problems between two different cohorts of CCSs in a single institution: 110 CCSs who visited the outpatient clinic for regular follow-ups between December 2010 and December 2015 (regular follow-up group) vs. 58 CCSs who underwent comprehensive medical examinations between February 2016 and September 2019 (active screening group). CCSs were defined as patients aged ≥ 18 years who had been diagnosed as having childhood cancer ≥ 10 years before and had survived without cancer for ≥ 5 years. Results: Patient characteristics were similar between the two groups except for primary diagnosis (more brain tumors and embryonal tumors in the active screening group) and treatment history (more alkylating agents used and surgical interventions performed in the active screening group). The prevalence and the median number of health problems were significantly higher in the active screening group than in the regular follow-up group: 93% vs. 67% and 1.0 [0.0-8.0] vs. 2.0 [0.0-7.0] respectively. In term of organ-specific health problems, pulmonary dysfunction, neurocognitive impairment, ocular abnormalities, and dental abnormalities were identified more in the active screening group, partly because these problems had not been assessed in the regular follow-up group. Nevertheless, the prevalence of grade 3-5 health problems was similar between the two groups, except for pulmonary dysfunction. Conclusion: Active screening using comprehensive medical examinations was effective for identifying health problems in CCSs. Although the prevalence of severe problems identified by both approaches was similar, comprehensive medical examinations could detect overlooked problems such as severe pulmonary dysfunction, dental maldevelopment, and borderline intellectual functioning, which might have an impact on quality of life in CCSs.

Intrathecal therapy in acute lymphoblastic leukemia case with spinal deformity.
Yurika Kuroko, Hiroki Yoshihara, Yosuke Hosoya, Atsushi Manabe, Daisuke Hasegawa
Pediatrics international : official journal of the Japan Pediatric Society, 64, 1, e14845, Jan. 2022, [International Magazine]
English, Scientific journal

Hepatoblastoma with bone/bone marrow metastasis in Li-Fraumeni syndrome patient.
Masataka Hasegawa, Minako Sugiyama, Yukayo Terashita, Yuko Cho, Atsushi Manabe
Pediatrics international : official journal of the Japan Pediatric Society, 64, 1, e15135, Jan. 2022, [International Magazine]
English, Scientific journal

NUDT15 variants confer high incidence of second malignancies in children with acute lymphoblastic leukemia.
Masanori Yoshida, Kazuhiko Nakabayashi, Wentao Yang, Aiko Sato-Otsubo, Shin-Ichi Tsujimoto, Hiroko Ogata-Kawata, Tomoko Kawai, Keisuke Ishiwata, Mika Sakamoto, Kohji Okamura, Kaoru Yoshida, Ryota Shirai, Tomoo Osumi, Takaya Moriyama, Rina Nishii, Hiroyuki Takahashi, Chikako Kiyotani, Yoko Shioda, Keita Terashima, Sae Ishimaru, Yuki Yuza, Masatoshi Takagi, Yuki Arakawa, Akitoshi Kinoshita, Moeko Hino, Toshihiko Imamura, Daisuke Hasegawa, Yozo Nakazawa, Mayuko Okuya, Harumi Kakuda, Nao Takasugi, Akiko Inoue, Kentaro Ohki, Takako Yoshioka, Shuichi Ito, Daisuke Tomizawa, Katsuyoshi Koh, Kimikazu Matsumoto, Masashi Sanada, Nobutaka Kiyokawa, Akira Ohara, Seishi Ogawa, Atsushi Manabe, Akira Niwa, Kenichiro Hata, Jun J Yang, Motohiro Kato
Blood advances, 5, 23, 5420, 5428, 14 Dec. 2021, [International Magazine]
English, Scientific journal, The effect of genetic variation on second malignant neoplasms (SMNs) remains unclear. First, we identified the pathogenic germline variants in cancer-predisposing genes among 15 children with SMNs after childhood leukemia/lymphoma using whole-exome sequencing. Because the prevalence was low, we focused on the association between SMNs and NUDT15 in primary acute lymphoblastic leukemia (ALL) cases. NUDT15 is one of the 6-mercaptopurine (6-MP) metabolic genes, and its variants are common in East Asian individuals. The prevalence of NUDT15 hypomorphic variants was higher in patients with SMNs (n = 14; 42.9%) than in the general population in the gnomAD database (19.7%; P = .042). In the validation study with a cohort of 438 unselected patients with ALL, the cumulative incidence of SMNs was significantly higher among those with (3.0%; 95% confidence interval [CI], 0.6% to 9.4%) than among those without NUDT15 variants (0.3%; 95% CI, 0.0% to 1.5%; P = .045). The 6-MP dose administered to patients with ALL with a NUDT15 variant was higher than that given to those without SMNs (P = .045). The 6-MP-related mutational signature was observed in SMN specimens after 6-MP exposure. In cells exposed to 6-MP, a higher level of 6-MP induced DNA damage in NUDT15-knockdown induced pluripotent stem cells. Our study indicates that NUDT15 variants may confer a risk of SMNs after treatment with 6-MP in patients with ALL.

Notable therapeutic response in a patient with systemic juvenile xanthogranuloma with KIF5B-ALK fusion.
Minako Sugiyama, Shinsuke Hirabayashi, Yukitomo Ishi, Junko Kikuchi, Ayako Ishikura, Hiroaki Motegi, Yuki Ueda, Saori Sawai, Kazuya Hara, Yukayo Terashita, Yuko Cho, Emi Takakuwa, Shohei Honda, Shigeru Yamaguchi, Ichiro Kinoshita, Atsushi Manabe
Pediatric blood & cancer, 68, 11, e29227, Nov. 2021, [International Magazine]
English

Hematopoietic stem cell transplantation for infants with high-risk KMT2A gene-rearranged acute lymphoblastic leukemia.
Takayuki Takachi, Tomoyuki Watanabe, Takako Miyamura, Akiko Moriya Saito, Takao Deguchi, Toshinori Hori, Tomomi Yamada, Shigeru Ohmori, Masami Haba, Yuki Aoki, Sae Ishimaru, Shinya Sasaki, Junjiro Ohshima, Akihiro Iguchi, Yoshiyuki Takahashi, Nobuyuki Hyakuna, Atsushi Manabe, Keizo Horibe, Eiichi Ishii, Katsuyoshi Koh, Daisuke Tomizawa
Blood advances, 5, 19, 3891, 3899, 12 Oct. 2021, [International Magazine]
English, Scientific journal, The role of allogeneic hematopoietic stem cell transplantation (HSCT) for infants with acute lymphoblastic leukemia (ALL) and KMT2A gene rearrangement (KMT2A-r) is controversial in terms of both its efficacy and potential for acute and late toxicities. In Japanese Pediatric Leukemia/Lymphoma Study Group trial MLL-10, by introducing intensive chemotherapy, indication of HSCT was restricted to patients with high-risk (HR) features only (KMT2A-r and either age <180 days or presence of central nervous system leukemia). Of the 56 HR patients, 49 achieved complete remission. Forty-three patients received HSCT in first remission including 38 patients receiving protocol-specified HSCT with conditioning consisting of individualized targeted doses of busulfan, etoposide, and cyclophosphamide. Three-year event-free survival (EFS) of 56.8% (95% confidence interval [CI], 42.4% to 68.8%) and overall survival of 80.2% (95% CI, 67.1% to 88.5%) were accomplished. Univariable analysis showed that Interfant-HR criteria and flow cytometric minimal residual disease (MRD; ≥0.01%), both at the end of induction and at the end of consolidation (EOC), were significantly associated with poorer EFS. In the multivariable analysis, positive MRD at EOC was solely associated with poor EFS (P < .001). Rapid pretransplant MRD clearance and tailored HSCT strategy in the MLL-10 trial resulted in a favorable outcome for infants with HR KMT2A-r ALL. However, considering the high rate of potentially life-threatening toxicities and the risk of late effects, its indication should be further restricted or even eliminated in the future by introducing more effective therapeutic modalities with minimal toxicities. This trial was registered at the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) as #UMIN000004801.

芽球性形質細胞様樹状細胞腫瘍の小児に対する造血細胞移植を回避した治療(Treatment in pediatric blastic plasmacytoid dendritic cell neoplasm(BPDCN) without transplantation)　　　　　　　　　　　　　　　
足洗 美穂, 西村 聡, 水城 和義, 出口 隆生, 真部 淳, 長谷川 大輔
日本血液学会学術集会, 83回, PS, 5, (一社)日本血液学会, Sep. 2021
English

Prospective validation of the provisional entity of RCC proposed by the WHO(和訳中)　　　　　　　　　　　　　　　
濱 麻人, 真部 淳, 長谷川 大輔, 野沢 和江, 成田 敦, 村松 秀城, 高橋 義行, 渡邉 健一郎, 小原 明, 伊藤 雅文, 小島 勢二
日本血液学会学術集会, 83回, OS1, 2, (一社)日本血液学会, Sep. 2021
English

Treatment in pediatric blastic plasmacytoid dendritic cell neoplasm(BPDCN) without transplantation(和訳中)　　　　　　　　　　　　　　　
足洗 美穂, 西村 聡, 水城 和義, 出口 隆生, 真部 淳, 長谷川 大輔
日本血液学会学術集会, 83回, PS, 5, (一社)日本血液学会, Sep. 2021
English

Risk factors for hospitalisation due to respiratory syncytial virus infection in children receiving prophylactic palivizumab.
Ayako Chida-Nagai, Hiroki Sato, Itsumi Sato, Masahiro Shiraishi, Daisuke Sasaki, Gaku Izumi, Hirokuni Yamazawa, Kazutoshi Cho, Atsushi Manabe, Atsuhito Takeda
European journal of pediatrics, 181, 2, 539, 547, 21 Aug. 2021, [International Magazine]
English, Scientific journal, Respiratory syncytial virus (RSV) is a common pathogen that causes extremely severe respiratory symptoms in the first few weeks and months of life. In infants with cardiopulmonary diseases, RSV infections have a significant clinical impact. Palivizumab, a humanised monoclonal antibody for RSV, has been shown to significantly reduce the rate of hospitalisation of high-risk infants diagnosed with RSV. However, we have experienced a significant number of RSV infections in our institution that required hospitalisation or intensive care, despite the administration of palivizumab. This study aimed to analyse the risk factors associated with severe RSV despite the use of palivizumab. We retrospectively reviewed the medical records of 688 patients who visited or were admitted to our hospital and received palivizumab. Thirty-seven (5.4%) patients required hospitalisation for RSV, despite receiving palivizumab. In addition, 31 of these patients (83.8%) required hospitalisation out of season for palivizumab injection. Preterm birth (≤ 28-week gestation), bronchopulmonary dysplasia (BPD), and trisomy 21 were risk factors for RSV-related hospitalisation in infected patients, despite receiving palivizumab. Furthermore, subgroup analysis of 69 patients with RSV revealed that hemodynamically significant congenital heart disease (CHD) was also a risk factor for RSV-related hospitalisation.Conclusion: Preterm birth (≤ 28 weeks of gestation), BPD, trisomy 21, hemodynamically significant CHD, and CHD requiring surgery or cardiac catheterisation/intervention during infancy could be considered when determining whether year-round administration of palivizumab is appropriate. What is Known: • Respiratory syncytial virus causes severe respiratory symptoms in infants, particularly those with cardiopulmonary diseases. • The use of palivizumab has reduced the rate of hospitalisation of infants diagnosed with RSV. Despite this, the rate of hospitalisation is still high. What is New: • We identified that preterm birth (≤ 28-week gestation), bronchopulmonary dysplasia, trisomy 21, and hemodynamically significant congenital heart disease were risk factors for RSV-related hospitalisation, even after receiving palivizumab treatment. • High-risk infants should be closely monitored and the prolonged use of palivizumab should be considered.

Clonal evidence for the development of neuroblastoma with extensive copy-neutral loss of heterozygosity arising in a mature teratoma.
Rintaro Ono, Hiroo Ueno, Kenichi Yoshida, Satoko Takahashi, Hiroki Yoshihara, Taiki Nozaki, Koyu Suzuki, Atsuko Nakazawa, Ryunosuke Saiki, Masafumi Seki, Junko Takita, Seishi Ogawa, Atsushi Manabe, Daisuke Hasegawa
Cancer science, 112, 7, 2921, 2927, Jul. 2021, [International Magazine]
English, Mature teratomas are usually benign tumors that rarely undergo malignant transformation. We report an advanced neuroblastoma arising in a mature teratoma of the ovary. Whole-exome sequencing identified extensive copy-neutral loss of heterozygosity (LOH) in both neuroblastoma and teratoma elements, suggesting that the neuroblastoma evolved from the teratoma. In addition, several truncating germline heterozygous variants in tumor suppressor genes, including RBL2 and FBXW12, became homozygous as a result of LOH. Collectively, we speculate that extensive LOH in teratoma cells may force heterozygous germline variants to become homozygous, which, in turn, may contribute to the development of neuroblastoma with the acquisition of additional chromosomal changes.

Extremely low 18F-fluorodeoxyglucose uptake in the brain of a patient with metastatic neuroblastoma and its recovery after chemotherapy: A case report.
Yutaka Hoshino, Minako Sugiyama, Kenji Hirata, Shohei Honda, Hitoshi Saito, Atsushi Manabe, Kohsuke Kudo
Acta radiologica open, 10, 7, 20584601211026810, 20584601211026810, Jul. 2021, [International Magazine]
English, Commonly, physiological 18F-fluorodeoxyglucose (FDG) uptake in the brain can be observed in 18F-FDG positron emission tomography. Abnormal uptake of 18F-FDG in the brain suggests disorders of central nervous system. Here, we present a case of extremely low 18F-FDG uptake in the brain of a 4-year-old girl with whole-body metastatic neuroblastoma. Almost missing of physiological 18F-FDG uptake in the brain was ascribed at least partly to the metastatic neuroblastoma. The brain could regain physiological 18F-FDG uptake after chemotherapy.

Absent XIAP expression in T cell blasts and causal XIAP mutations including non-coding deletion.
Shimaa Said Mohamed Ali Abdrabou, Nariaki Toita, Shin Ichihara, Yusuke Tozawa, Michiko Takahashi, Shin-Ichi Fujiwara, Toshifumi Ashida, Osamu Ohara, Tadashi Ariga, Atsushi Manabe, Mutsuko Konno, Masafumi Yamada
Pediatrics international : official journal of the Japan Pediatric Society, 64, 1, e14892, 18 Jun. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: X-linked inhibitor of apoptosis protein (XIAP) deficiency is one of inborn errors of immunity characterized by recurrent hemophagocytic lymphohistiocytosis (HLH) and refractory inflammatory bowel disease (IBD) mimicking Crohn's disease (CD). The aim of this study is to make accurate diagnosis of XIAP deficiency based on genetic and XIAP expression studies and to investigate endoscopic findings shared by patients with this disease. METHODS: Four male patients with recurrent HLH and long-term refractory IBD were studied for the diagnosis of XIAP deficiency. Parallelly, endoscopic findings of the four patients were also studied. RESULTS: These four patients were diagnosed with XIAP deficiency based on the absent XIAP expression in cultured T-cell blasts. Sequence analysis of the responsible gene, XIAP, demonstrated two novel nonsense mutations of p.Gln114X and p.Glu25X, and a previously reported nonsense mutation of p.Arg381X. Although no mutations in the coding region were detected in the fourth patient, further studies demonstrated a novel 2199 bp deletion encompassing non-coding exon 1, presumably affecting transcription and stability of XIAP mRNA. All of the patients eventually underwent hematopoietic stem cell transplantation, leading to a complete or partial remission of IBD. These four patients shared an endoscopic finding of multiple wide and longitudinal ulcers with straight and non-raised edge in the colon. CONCLUSIONS: XIAP expression in T-cell blasts could facilitate the diagnosis of this disease especially with causal mutations in non-coding regions.

Clinical significance of comprehensive genomic profiling tests covered by public insurance in patients with advanced solid cancers in Hokkaido, Japan
Junko Kikuchi, Yoshihito Ohhara, Kohichi Takada, Hiroki Tanabe, Kazuteru Hatanaka, Toraji Amano, Kanako C Hatanaka, Yutaka Hatanaka, Takashi Mitamura, Momoko Kato, Yuka Shibata, Ichiro Yabe, Akira Endoh, Yoshito Komatsu, Yoshihiro Matsuno, Minako Sugiyama, Atsushi Manabe, Akihiro Sakurai, Masato Takahashi, Hirohito Naruse, Yoshihiro Torimoto, Hirotoshi Dosaka-Akita, Ichiro Kinoshita
Japanese Journal of Clinical Oncology, 51, 5, 753, 761, Oxford University Press (OUP), 30 Apr. 2021
Scientific journal,


Comprehensive cancer genomic profiling has been used recently for patients with advanced solid cancers. Two cancer genomic profiling tests for patients with no standard treatment are covered by Japanese public health insurance since June 2019.





We prospectively analyzed data of 189 patients with solid cancers who underwent either of the two-cancer genomic profiling tests at Hokkaido University Hospital and its liaison hospitals and whose results were discussed in molecular tumor board at Hokkaido University Hospital between August 2019 and July 2020.





All 189 patients had appropriate results. Actionable gene alterations were identified in 93 patients (49%). Frequent mutations included PIK3CA (12%) mutation, BRCA1/2 alteration (7%), ERBB2 amplification (6%) and tumor mutation burden-High (4%). The median turnaround time from sample shipping to acquisition by the expert panel was 26 days. Although 115 patients (61%) were provided with information for genotype-matched therapies, only 21 (11%) received them. Notably, four of eight patients below the age of 20 years were provided information for genotype-matched therapies, and three received them. Their response rates and disease control rates were 29% and 67%, respectively. Most patients who did not undergo the genotype-matched therapies were provided information for only investigational drugs in phases I and II at distant clinical trial sites in central Japan. Twenty-six patients were informed of suspected germline findings, while 11 patients (42%) received genetic counseling.





The publicly reimbursed cancer genomic profilings may lead to the modest but favorable therapeutic efficacy of genotype-matched therapy for solid cancer patients with no standard therapy. However, poor access to genotype-matched therapy needs to be resolved.

Flurothyl-induced seizure paradigm revealed higher seizure susceptibility in middle-aged Angelman syndrome mouse model.
Kiyoshi Egawa, Sachiko Nakakubo, Shuhei Kimura, Takeru Goto, Atsushi Manabe, Hideaki Shiraishi
Brain & development, 43, 4, 515, 520, Apr. 2021, [International Magazine]
English, Scientific journal, INTRODUCTION: Epilepsy is one of the main clinical problems in Angelman syndrome (AS). Seizures typically start in early childhood then decrease or are often alleviated by young adulthood. Several studies using AS model mice showed comparable seizure susceptibility during young adulthood. In contrast, the course of epilepsy post young adulthood differs from persistently relieved to rerising among reports. To elucidate this, we evaluated the seizure susceptibility of AS model mice of two different ages. METHODS: Mice lacking maternal Ube3a gene (Ube3am-/p+) of C57BL/6 background or their littermate wild type (WT) were divided into two groups by age, 2 to 3 months (2-3 M) and 6 to 12 months (6-12 M), corresponding to adolescent to young adult aged and middle aged humans, respectively. Seizure susceptibility was evaluated by flurothyl inhalation or intraperitoneal injection of pentylenetetrazole (PTZ IP)-induced acute seizure protocol. RESULTS: In the flurothyl-induced seizure paradigm, the latency to seizure occurrence had a significant interaction with genotype and age. Post-hoc analysis revealed that the latency was significantly shorter at 6-12 M than at 2-3 M in Ube3am-/p+ mice, and in Ube3am-/p+ mice than in WT mice at 6-12 M. No significant interaction or difference was observed by PTZ IP. CONCLUSION: The flurothyl-induced seizure paradigm revealed that seizure susceptibility of Ube3am-/p+ mice increased with age, similar to clinical studies reporting the reappearance of epilepsy in older age. The flurothyl-induced seizure paradigm applied to middle-aged Ube3am-/p+ mice could be a suitable protocol for screening drugs against seizures in AS.

Incidence of alveolar capillary dysplasia with misalignment of pulmonary veins in infants with unexplained severe pulmonary hypertension: The roles of clinical, pathological, and genetic testing.
Tetsuo Onda, Takuma Akimoto, Itaru Hayasaka, Masahiko Ikeda, Yuta Furuse, Akiko Ando, Yuichi Nakamura, Ryota Honjo, Atsushi Manabe, Itsuko Furuta, Kazutoshi Cho
Early human development, 155, 105323, 105323, Apr. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a rare and fatal disorder that occurs in the developing fetal lungs; at birth, infants exhibit an oxygenation disorder accompanied by severe pulmonary hypertension (PH) and have a very short life span. ACDMPV is definitively diagnosed by pathological findings, and infants born with unexplained severe PH may not be properly diagnosed without a biopsy or autopsy. METHODS: Japanese infants with unexplained severe PH were enrolled in this study. Genetic analyses were performed on DNA extracted from peripheral blood leukocytes. Sanger sequencing or next-generation sequencing was performed by coding exons and introns for FOXF1 in all samples. For individuals without pathogenic exonic variants, multiplex ligation-dependent probe amplification was performed to identify copy number variations (CNVs) in exons, introns, and in the upstream region of FOXF1. RESULTS: This study included 30 infants who were diagnosed over the course of nine years. Four individuals had the pathogenic variations on the exon 1 of FOXF1, including two frameshift and two missense variations. Pathogenic CNVs were found in another five individuals. CONCLUSION: In the pathologically proven ACDMPV patients, the ratios of cases with exonic variations, CNVs, and no genetic findings were reported as 45%, 45% and 10%, respectively. We estimate that about 30% (10 (9 + 1) out of 30) of individuals with unexplained severe PH had ACDMPV.

High-grade neuroepithelial tumor with BCL6 corepressor-alteration presenting pathological and radiological calcification: A case report.
Yukitomo Ishi, Ai Shimizu, Emi Takakuwa, Minako Sugiyama, Michinari Okamoto, Hiroaki Motegi, Shinsuke Hirabayashi, Yuko Cho, Akihiro Iguchi, Atsushi Manabe, Sumihito Nobusawa, Shinya Tanaka, Shigeru Yamaguchi
Pathology international, 71, 5, 348, 354, 13 Mar. 2021, [International Magazine]
English, A 5-year-old girl presented with headache and vomiting. Head computed tomography and magnetic resonance imaging showed a right frontal lobe tumor with marked calcification. The patient underwent resection surgery with suspicion of anaplastic ependymoma, and the tumor was gross totally removed. Pathological examination revealed areas of dense tumor cells with a high nucleocytoplasmic ratio and myxoid areas consisting of tumor cells with a round-shaped nucleus and eosinophilic cytoplasm. Perivascular pseudorosette, necrosis, circumscribed growth, and microcalcification were also observed. Immunohistochemistry demonstrated negative staining for glial fibrillary protein and epithelial membrane antigen. Diagnosis of a high-grade neuroepithelial tumor (HGNET) with BCL6 corepressor (BCOR) alteration was made based on pathological findings and internal tandem duplication in the exon 15 of BCOR. Although calcification on radiological and pathological examination is not typical, it would be essential to recognize that calcification could appear in HGNET-BCOR.

Clinical characteristics and outcomes of B-ALL with ZNF384 rearrangements: a retrospective analysis by the Ponte di Legno Childhood ALL Working Group.
Shinsuke Hirabayashi, Ellie R Butler, Kentaro Ohki, Nobutaka Kiyokawa, Anke K Bergmann, Anja Möricke, Judith M Boer, Hélène Cavé, Giovanni Cazzaniga, Allen Eng Juh Yeoh, Masashi Sanada, Toshihiko Imamura, Hiroto Inaba, Charles Mullighan, Mignon L Loh, Ulrika Norén-Nyström, Agata Pastorczak, Lee-Yung Shih, Marketa Zaliova, Ching-Hon Pui, Oskar A Haas, Christine J Harrison, Anthony V Moorman, Atsushi Manabe
Leukemia, 35, 11, 3272, 3277, 10 Mar. 2021, [International Magazine]
English, Scientific journal

In-Hospital Management Might Reduce Induction Deaths in Pediatric Patients With Acute Lymphoblastic Leukemia: Results From a Japanese Cohort.
Shunsuke Nakagawa, Motohiro Kato, Toshihiko Imamura, Chihaya Imai, Katsuyoshi Koh, Yoshifumi Kawano, Yasuto Shimomura, Arata Watanabe, Atsushi Kikuta, Akiko Saito, Keizo Horibe, Atsushi Manabe, Akira Ohara, Yasuhiro Okamoto
Journal of pediatric hematology/oncology, 43, 2, 39, 46, 01 Mar. 2021, [International Magazine]
English, Scientific journal, Induction deaths (ID) remain a critical issue in the treatment of pediatric patients with acute lymphoblastic leukemia (ALL). The reported rate of ID in this population is 1% or higher. We speculate that this proportion might be lower in Japan because of mandatory hospitalization during induction therapy to manage complications. We retrospectively analyzed the incidence of ID among children with ALL enrolled in 4 Japanese study groups between 1994 and 2013. Among 5620 children, 41 (0.73%) cases of ID were noted. The median age was 6.5 years; 24 children were female, and 7 had T-cell ALL. Infection was the most common cause of ID (n=22), but the incidence (0.39%) was lower than that reported in western countries. Mortality within 48 hours from the onset of infection was low, comprising 25% of infection-related deaths. The incidence of infections caused by Bacillus species was low. Only 1 patient died because of Aspergillus infection. Fatal infections mostly occurred during the third week of induction therapy. Our findings suggest that close monitoring, stringent infection control, and immediate administration of appropriate antibiotics through hospitalization might be important strategies in reducing the rate of infection-related ID in pediatric patients with ALL.

生後早期に血管内塞栓術を施行したガレン大静脈瘤の早産児例　　　　　　　　　　　　　　　
本庄 遼太, 中村 雄一, 安藤 明子, 恩田 哲雄, 古瀬 優太, 長 和俊, 武田 充人, 真部 淳
日本小児科学会雑誌, 125, 2, 348, 348, (公社)日本小児科学会, Feb. 2021
Japanese

先天性心疾患術後から乳び胸管理に難渋しリンパ管造影を実施したヌーナン症候群の乳児例　　　　　　　　　　　　　　　
佐藤 逸美, 白石 真大, 佐々木 大輔, 永井 礼子, 泉 岳, 山澤 弘州, 武田 充人, 真部 淳
日本小児科学会雑誌, 125, 2, 318, 318, (公社)日本小児科学会, Feb. 2021
Japanese

Ruxolitinib for hematopoietic cell transplantation-associated hemophagocytic lymphohistiocytosis.
Rintaro Ono, Miho Ashiarai, Shinsuke Hirabayashi, Kazuyoshi Mizuki, Yosuke Hosoya, Hiroki Yoshihara, Junya Ohtake, Shinichiro Mori, Atsushi Manabe, Daisuke Hasegawa
International journal of hematology, 113, 2, 297, 301, Feb. 2021, [Domestic magazines]
English, Scientific journal, Hemophagocytic lymphohistiocytosis (HLH) is a severe complication after allogeneic hematopoietic cell transplantation (HCT) and can cause graft failure or multi-organ failure. Here, we report two children with refractory HCT-associated HLH treated with ruxolitinib. In the first patient, ruxolitinib resolved fever, cytopenia and hyperferritinemia. In another patient, although severe hepatic failure, which developed and worsened before the administration of ruxolitinib, was irreversible, rapid improvement in fever, leukopenia and hyperferritinemia was observed. Of note, multiplex cytokine profiling showed amelioration of cytokine storm in both patients. Ruxolitinib may be an encouraging option for HCT-associated HLH.

Acquisition of monosomy 7 and a RUNX1 mutation in Pearson syndrome.
Akira Nishimura, Shinsuke Hirabayashi, Daisuke Hasegawa, Kenichi Yoshida, Yuichi Shiraishi, Miho Ashiarai, Yosuke Hosoya, Tohru Fujiwara, Hideo Harigae, Satoru Miyano, Seishi Ogawa, Atsushi Manabe
Pediatric blood & cancer, 68, 2, e28799, Feb. 2021, [International Magazine]
English, Scientific journal, Pearson syndrome (PS) is a very rare and often fatal multisystem disease caused by deletions in mitochondrial DNA that result in sideroblastic anemia, vacuolization of marrow precursors, and pancreatic dysfunction. Spontaneous recovery from anemia is often observed within several years of diagnosis. We present the case of a 4-month-old male diagnosed with PS who experienced prolonged severe pancytopenia preceding the emergence of monosomy 7. Whole-exome sequencing identified two somatic mutations, including RUNX1 p.S100F that was previously reported as associated with myeloid malignancies. The molecular defects associated with PS may have the potential to progress to advanced myelodysplastic syndrome .

Correction to: FLEND (nelarabine, fludarabine, and etoposide) for relapsed T-cell acute lymphoblastic leukemia in children: a report from Japan Children's Cancer Group.
Tadashi Kumamoto, Hiroaki Goto, Chitose Ogawa, Toshinori Hori, Takao Deguchi, Takuya Araki, Akiko M Saito, Atsushi Manabe, Keizo Horibe, Hidemi Toyoda
International journal of hematology, 113, 2, 308, 309, Feb. 2021, [Domestic magazines]
English

An international retrospective study for tolerability of 6-mercaptopurine on NUDT15 bi-allelic variants in children with acute lymphoblastic leukemia.
Yoichi Tanaka, Allen Eng Juh Yeoh, Takaya Moriyama, Chi-Kong Li, Ko Kudo, Yuki Arakawa, Jassada Buaboonnam, Hui Zhang, Hsi-Che Liu, Hany Ariffin, Zhiwei Chen, Shirley K Y Kham, Rina Nishii, Daisuke Hasegawa, Junya Fujimura, Dai Keino, Kensuke Kondoh, Atsushi Sato, Takahiro Ueda, Masaki Yamamoto, Yuichi Taneyama, Moeko Hino, Masatoshi Takagi, Akira Ohara, Etsuro Ito, Katsuyoshi Koh, Hiroki Hori, Atsushi Manabe, Jun J Yang, Motohiro Kato
Haematologica, 106, 7, 2026, 2029, 28 Jan. 2021, [International Magazine]
English, Scientific journal, Not available.

Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants.
Ayumu Arakawa, Hitoshi Ichikawa, Takashi Kubo, Noriko Motoi, Tadashi Kumamoto, Miho Nakajima, Kan Yonemori, Emi Noguchi, Kuniko Sunami, Kouya Shiraishi, Hiroki Kakishima, Hiroshi Yoshida, Tomoro Hishiki, Naonori Kawakubo, Takafumi Kuroda, Takako Kiyokawa, Kyosuke Yamada, Nozomu Yanaihara, Kazuaki Takahashi, Aikou Okamoto, Shinsuke Hirabayashi, Daisuke Hasegawa, Atsushi Manabe, Kentaro Ono, Masaki Matsuoka, Yasuhito Arai, Yosuke Togashi, Tatsuhiro Shibata, Hiroyoshi Nishikawa, Kazunori Aoki, Noboru Yamamoto, Takashi Kohno, Chitose Ogawa
The New England journal of medicine, 384, 1, 42, 50, 07 Jan. 2021, [International Magazine]
English, Scientific journal, Two cases of pediatric lung cancer (in 23-month-old and 6-year-old boys) resulting from mother-to-infant transmission of uterine cervical tumors were incidentally detected during routine next-generation sequencing of paired samples of tumor and normal tissue. Spontaneous regression of some lesions in the first child and slow growth of the tumor mass in the second child suggested the existence of alloimmune responses against the transmitted tumors. Immune checkpoint inhibitor therapy with nivolumab led to a strong regression of all remaining tumors in the first child. (Funded by the Japan Agency for Medical Research and Development and others; TOP-GEAR UMIN Clinical Trials Registry number, UMIN000011141.).

Diagnostic Capability of Cerebrospinal Fluid-Placental Alkaline Phosphatase Value in Intracranial Germ Cell Tumor.
Michinari Okamoto, Shigeru Yamaguchi, Yukitomo Ishi, Hiroaki Motegi, Takashi Mori, Takayuki Hashimoto, Yukayo Terashita, Shinsuke Hirabayashi, Minako Sugiyama, Akihiro Iguchi, Yuko Cho, Atsushi Manabe, Kiyohiro Houkin
Oncology, 99, 1, 23, 31, 2021, [International Magazine]
English, Scientific journal, OBJECTIVE: Most types of intracranial germ cell tumors (IGCTs) are sensitive to chemoradiation. However, biopsy specimens are usually small and thus cannot be used for obtaining an accurate pathological diagnosis. Recently, the cerebrospinal fluid (CSF) placental alkaline phosphatase (PLAP) value has been considered a new biomarker of IGCTs. The present study aimed to evaluate the discriminatory characteristics of the CSF-PLAP value upon diagnosis and at the time of recurrence in patients with IGCTs. METHODS: Between 2015 and 2019, this study included 37 patients with tumors located in the intraventricular and/or periventricular region. The CSF-PLAP level was assessed before the patients received any treatment. The PLAP level was evaluated during and after first-line chemoradiotherapy in 7 patients with IGCTs. The CSF-PLAP values were compared according to histological diagnosis, and the correlation between these values and radiographical features was assessed. The CSF-PLAP values of 6 patients with IGCTs with suspected recurrence were evaluated based on neuroimaging findings. RESULTS: The CSF-PLAP values were significantly higher in patients with IGCTs than in those with other types of brain tumor (n = 19 vs. 18; median: 359.0 vs. <8.0 pg/mL). The specificity and sensitivity were 88 and 95%, respectively, with a cutoff value of 8.0 pg/mL. In patients with IGCT, the CSF-PLAP value was higher in patients with germinoma than in those with nongerminomatous germ cell tumors (n = 12 vs. 7; median: 415.0 vs. 359.0 pg/mL). Regarding the time course, the CSF-PLAP value decreased to below the detection limit after the reception of first-line chemoradiotherapy in all 7 patients. A significant correlation was observed between the initial CSF-PLAP value and the tumor reduction volume after receiving first-line chemoradiotherapy (p < 0.0003, R2 = 0.6165, logY = 1.202logX - 1.727). Among the patients with suspected IGCT recurrence (n = 6), the CSF-PLAP value was high in patients with recurrence (n = 3; median: 259.0 pg/mL), and that in patients (n = 3) without recurrence was below the lower detection limit. CONCLUSIONS: The CSF-PLAP level is a useful biomarker during the initial diagnosis of IGCTs and at the time of recurrence. It may be associated with the volume of germinomatous components of tumors.

CAN HIGH LEVEL SERUM HCG-B BE CONSIDERED EQUIVALENT TO A DIAGNOSIS OF CHORIOCARCINOMA IN PRIMARY CENTRAL NERVOUS SYSTEM GERM-CELL TUMOR?
Hiroaki Motegi, Shigeru Yamaguchi, Yukitomo Ishi, Michinari Okamoto, Akihiro Iguchi, Yuko Cho, Minako Sugiyama, Atsushi Manabe, Kiyohiro Houkin
NEURO-ONCOLOGY, 22, 329, 330, Dec. 2020, [Peer-reviewed]
English

当院の先天性門脈体循環シャント症例の臨床検討　　　　　　　　　　　　　　　
辻岡 孝郎, 泉 岳, 武田 充人, 小杉山 清隆, 山澤 弘州, 谷口 宏太, 永井 礼子, 本多 昌平, 阿保 大介, 川村 典生, 真部 淳
日本小児循環器学会雑誌, 36, Suppl.2, s2, 356, (NPO)日本小児循環器学会, Nov. 2020
Japanese

当院の先天性門脈体循環シャント症例の臨床検討　　　　　　　　　　　　　　　
辻岡 孝郎, 泉 岳, 武田 充人, 小杉山 清隆, 山澤 弘州, 谷口 宏太, 永井 礼子, 本多 昌平, 阿保 大介, 川村 典生, 真部 淳
日本小児循環器学会雑誌, 36, Suppl.2, s2, 356, (NPO)日本小児循環器学会, Nov. 2020
Japanese

FLEND (nelarabine, fludarabine, and etoposide) for relapsed T-cell acute lymphoblastic leukemia in children: a report from Japan Children's Cancer Group.
Tadashi Kumamoto, Hiroaki Goto, Chitose Ogawa, Toshinori Hori, Takao Deguchi, Takuya Araki, Akiko M Saito, Atsushi Manabe, Keizo Horibe, Hidemi Toyoda
International journal of hematology, 112, 5, 720, 724, Nov. 2020, [Domestic magazines]
English, Scientific journal, Nelarabine is a key drug for T-cell acute lymphoblastic leukemia (T-ALL). Fludarabine and etoposide might have synergistic effect with nelarabine by inhibiting ribonucleotide reductase and by preparing cell cycle for G1/S phase, respectively. We had started phase 1/2 multicenter clinical trial of combination chemotherapy consisted of nelarabine, fludarabine, and etoposide (FLEND therapy) for children with relapsed/refractory T-ALL which has been conducted since October 2011. Although we could not complete this trial because of recruitment difficulties, we treated five children with first-relapsed T-ALL which were enrolled in the phase 1 dose escalation study of fludarabine and etoposide with nelarabine. No dose-limiting toxicity occurred, and frequent grade 3-4 toxicity was hematological toxicity and febrile neutropenia, as expected. There was no neurotoxicity. All 2 patients who received the target dose of FLEND, in which nelarabine (650 mg/m2), fludarabine (30 mg/m2), and etoposide (100 mg/m2) were administered for 5 consecutive days, were induced to complete remission. We concluded that FLEND might be safe and one of the promising combination chemotherapies to relapsed/refractory T-ALL.

Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia.
Hiroo Ueno, Kenichi Yoshida, Yusuke Shiozawa, Yasuhito Nannya, Yuka Iijima-Yamashita, Nobutaka Kiyokawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Tomoya Isobe, Masafumi Seki, Shunsuke Kimura, Hideki Makishima, Masahiro M Nakagawa, Nobuyuki Kakiuchi, Keisuke Kataoka, Tetsuichi Yoshizato, Dai Nishijima, Takao Deguchi, Kentaro Ohki, Atsushi Sato, Hiroyuki Takahashi, Yoshiko Hashii, Sadao Tokimasa, Junichi Hara, Yoshiyuki Kosaka, Koji Kato, Takeshi Inukai, Junko Takita, Toshihiko Imamura, Satoru Miyano, Atsushi Manabe, Keizo Horibe, Seishi Ogawa, Masashi Sanada
Blood advances, 4, 20, 5165, 5173, 27 Oct. 2020, [International Magazine]
English, Scientific journal, Recent genetic studies using high-throughput sequencing have disclosed genetic alterations in B-cell precursor acute lymphoblastic leukemia (B-ALL). However, their effects on clinical outcomes have not been fully investigated. To address this, we comprehensively examined genetic alterations and their prognostic impact in a large series of pediatric B-ALL cases. We performed targeted capture sequencing in a total of 1003 pediatric patients with B-ALL from 2 Japanese cohorts. Transcriptome sequencing (n = 116) and/or array-based gene expression analysis (n = 120) were also performed in 203 (84%) of 243 patients who were not categorized into any disease subgroup by panel sequencing or routine reverse transcription polymerase chain reaction analysis for major fusions in B-ALL. Our panel sequencing identified novel recurrent mutations in 2 genes (CCND3 and CIC), and both had positive correlations with ETV6-RUNX1 and hypodiploid ALL, respectively. In addition, positive correlations were also newly reported between TCF3-PBX1 ALL with PHF6 mutations. In multivariate Cox proportional hazards regression models for overall survival, TP53 mutation/deletion, hypodiploid, and MEF2D fusions were selected in both cohorts. For TP53 mutations, the negative effect on overall survival was confirmed in an independent external cohort (n = 466). TP53 mutation was frequently found in IGH-DUX4 (5 of 57 [9%]) ALL, with 4 cases having 17p LOH and negatively affecting overall survival therein, whereas TP53 mutation was not associated with poor outcomes among NCI (National Cancer Institute) standard risk (SR) patients. A conventional treatment approach might be enough, and further treatment intensification might not be necessary, for patients with TP53 mutations if they are categorized into NCI SR.

A risk-stratified therapy for infants with acute lymphoblastic leukemia: a report from the JPLSG MLL-10 trial.
Daisuke Tomizawa, Takako Miyamura, Toshihiko Imamura, Tomoyuki Watanabe, Akiko Moriya Saito, Atsushi Ogawa, Yoshihiro Takahashi, Masahiro Hirayama, Tomohiko Taki, Takao Deguchi, Toshinori Hori, Masashi Sanada, Shigeru Ohmori, Masami Haba, Akihiro Iguchi, Yuki Arakawa, Yuhki Koga, Atsushi Manabe, Keizo Horibe, Eiichi Ishii, Katsuyoshi Koh
Blood, 136, 16, 1813, 1823, 15 Oct. 2020, [International Magazine]
English, Scientific journal, The prognosis for infants with acute lymphoblastic leukemia (ALL), particularly those with KMT2A gene rearrangement (KMT2A-r), is dismal. Continuous efforts have been made in Japan to investigate the role of hematopoietic stem cell transplantation (HSCT) for infants with KMT2A-r ALL, but improvement in outcome was modest. In the Japanese Pediatric Leukemia/Lymphoma Study Group MLL-10 trial, infants with ALL were stratified into 3 risk groups (low risk [LR], intermediate risk [IR], and high risk [HR]) according to KMT2A status, age, and presence of central nervous system leukemia. Children's Oncology Group AALL0631 modified chemotherapy with the addition of high-dose cytarabine in early intensification was introduced to KMT2A-r patients, and the option of HSCT was restricted to HR patients only. The role of minimal residual disease (MRD) was also evaluated. Ninety eligible infants were stratified into LR (n = 15), IR (n = 19), or HR (n = 56) risk groups. The 3-year event-free survival (EFS) rate for patients with KMT2A-r ALL (IR + HR) was 66.2% (standard error [SE], 5.6%), and for those with germline KMT2A (KMT2A-g) ALL (LR), the 3-year EFS rate was 93.3% (SE, 6.4%). The 3-year EFS rate was 94.4% (SE, 5.4%) for IR patients and 56.6% (SE, 6.8%) for HR patients. In multivariable analysis, female sex and MRD ≥0.01% at the end of early consolidation were significant factors for poor prognosis. Risk stratification and introduction of intensive chemotherapy in this study were effective and were able to eliminate HSCT for a subset of infants with KMT2A-r ALL. Early clearance of MRD seems to have translated into favorable outcomes and should be incorporated into risk stratifications in future trials. This trial was registered at the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) as #UMIN000004801.

髄腔内抗がん剤注射が困難であった小児急性リンパ性白血病の2症例
黒子 由梨香, 吉原 宏樹, 山本 薫, 上野 浩生, 鈴木 優里, 細谷 要介, 加茂 実武, 真部 淳, 長谷川 大輔
日本小児血液・がん学会雑誌, 57, 4, 219, 219, (一社)日本小児血液・がん学会, Oct. 2020
Japanese

下垂体単独ランゲルハンス細胞組織球症の一例　　　　　　　　　　　　　　　
渡邊 敏史, 平林 真介, 原 和也, 杉山 未奈子, 長 祐子, 高桑 恵美, 茂木 洋晃, 山口 秀, 井口 晶裕, 真部 淳
日本小児血液・がん学会雑誌, 57, 4, 306, 306, (一社)日本小児血液・がん学会, Oct. 2020
Japanese

カテコラミン過剰分泌による症状を呈した神経芽腫の2例
中山 加奈子, 中村 明枝, 橋本 佳帆子, 鎌田 瑛理, 菱村 希, 山口 健史, 井口 晶裕, 本多 昌平, 木田 毅, 真部 淳
日本内分泌学会雑誌, 96, 2, 552, 552, (一社)日本内分泌学会, Oct. 2020
Japanese

AYA世代小児がん経験者における口腔内状態と晩期合併症の検討　　　　　　　　　　　　　　　
細谷 要介, 宇治川 清登, 長谷川 大輔, 鈴木 優里, 小林 京子, 真部 淳, 石田 也寸志, 小澤 靖弘, 小澤 美和
日本小児血液・がん学会雑誌, 57, 4, 276, 276, (一社)日本小児血液・がん学会, Oct. 2020
Japanese

小児がん経験者の就労状況への関連要因の探索　　　　　　　　　　　　　　　
小林 京子, 石田 也寸志, 小澤 美和, 郡司 美千代, 細谷 要介, 長谷川 大輔, 真部 淳
日本小児血液・がん学会雑誌, 57, 4, 380, 380, (一社)日本小児血液・がん学会, Oct. 2020
Japanese

Onset mechanism of a female patient with Dent disease 2.
Takayuki Okamoto, Nana Sakakibara, Kandai Nozu, Toshiyuki Takahashi, Asako Hayashi, Yasuyuki Sato, China Nagano, Masafumi Matsuo, Kazumoto Iijima, Atsushi Manabe
Clinical and experimental nephrology, 24, 10, 946, 954, Oct. 2020, [Domestic magazines]
English, Scientific journal, BACKGROUND: Approximately 15% of patients with Dent disease have pathogenic variants in the OCRL gene on Xq25-26, a condition that is referred to as Dent disease 2 (Dent-2). Dent-2 patients sometimes show mild extrarenal features of Lowe syndrome, such as mild mental retardation, suggesting that Dent-2 represents a mild form of Lowe syndrome. To date, eight female patients with Lowe syndrome have been reported, but no female Dent-2 patients have been reported. METHODS: In this study, we performed genetic testing of the first female Dent-2 patient to detect the presence of an OCRL variant. Aberrant splicing was demonstrated by in vivo, in vitro, and in silico assays, and skewed X-chromosome inactivation (XCI) in our patient and asymptomatic mothers of three Lowe patients with the heterozygous OCRL variant was evaluated by HUMARA assays using genomic DNA and RNA expression analysis. RESULTS: Our patient had an OCRL heterozygous intronic variant of c.1603-3G > C in intron 15 that led to a 169-bp insertion in exon 16, yielding the truncating mutation r.1602_1603ins (169) (p.Val535Glyfs*6) in exon 16. HUMARA assays of leukocytes obtained from this patient demonstrated incompletely skewed XCI (not extremely skewed). On the other hand, the asymptomatic mothers of 3 Lowe patients demonstrated random XCI. These results may lead to our patient's Dent-2 phenotype. CONCLUSIONS: This is the first report of a female patient clinically and genetically diagnosed with Dent-2 caused by an OCRL heterozygous splicing site variant and skewed XCI. Skewed XCI may be one of the factors associated with phenotypic diversity in female patients with Lowe syndrome and Dent-2.

Impact of immunophenotypic characteristics on genetic subgrouping in childhood acute lymphoblastic leukemia: Tokyo Children's Cancer Study Group (TCCSG) study L04-16.
Kentaro Ohki, Hiroyuki Takahashi, Takashi Fukushima, Toru Nanmoku, Shinpei Kusano, Makiko Mori, Yozo Nakazawa, Yuki Yuza, Masahiro Migita, Haruna Okuno, Akira Morimoto, Hiroshi Yoshino, Motohiro Kato, Yasuhide Hayashi, Atsushi Manabe, Akira Ohara, Daisuke Hasegawa, Takeshi Inukai, Daisuke Tomizawa, Katsuyoshi Koh, Nobutaka Kiyokawa
Genes, chromosomes & cancer, 59, 10, 551, 561, Oct. 2020, [International Magazine]
English, Scientific journal, Immunophenotyping was performed in 1044 consecutive childhood acute lymphoblastic leukemia (ALL) patients enrolled in the Tokyo Children's Cancer Study Group L04-16 trial, revealing novel findings associated with genetic abnormalities. In addition to TCF3-PBX1 and MEF2D fusions, the CD10(+) subtype of KMT2A-MLLT3-positive ALL frequently exhibited the cytoplasmic-μ(+) pre-B ALL immunophenotype. Although ETV6-RUNX1 was significantly correlated with myeloid antigen expression, more than half of patients expressed neither CD33 nor CD13, while the CD27(+) /CD44(-) immunophenotype was maintained. Expression of CD117 and CD56 in B-cell precursor-ALL was limited to certain subtypes including ETV6-RUNX1 and KMT2A-MLLT3. Besides BCR-ABL1, CRLF2, hyperdiploidy, and hypodiploidy, CD66c was also expressed in Ph-like kinase fusion-, PAX5 fusion-, and DUX4 fusion-positive ALL, but not in MEF2D fusion-positive ALL, indicating constant selectivity of CD66c expression. In T-ALL, SIL-TAL1-positive patients were likely to exhibit a more mature immunophenotype. Expression of CD21 and CD10 was not rare in T-ALL, while lack of CD28 was an additional feature of early T-cell precursor-ALL. Considering the immunophenotype as a prognostic maker, MEF2D fusion-positive ALL with CD5 expression may be associated with a poorer prognosis in comparison with those lacking CD5 expression. In cases with characteristic marker expression, the presence of certain fusion transcripts could be predicted accurately.

Clinical utility of target capture-based panel sequencing in hematological malignancies: A multicenter feasibility study.
Takahiko Yasuda, Masashi Sanada, Dai Nishijima, Takashi Kanamori, Yuka Iijima, Hiroyoshi Hattori, Akiko Saito, Hiroaki Miyoshi, Yuichi Ishikawa, Norio Asou, Kensuke Usuki, Shinsuke Hirabayashi, Motohiro Kato, Masaki Ri, Hiroshi Handa, Tadao Ishida, Hirohiko Shibayama, Masahiro Abe, Chisako Iriyama, Kennosuke Karube, Momoko Nishikori, Koichi Ohshima, Keisuke Kataoka, Kenichi Yoshida, Yuichi Shiraishi, Hiroaki Goto, Souichi Adachi, Ryoji Kobayashi, Hitoshi Kiyoi, Yasushi Miyazaki, Seishi Ogawa, Hiroki Kurahashi, Hisayuki Yokoyama, Atsushi Manabe, Shinsuke Iida, Akihiro Tomita, Keizo Horibe
Cancer science, 111, 9, 3367, 3378, Sep. 2020, [International Magazine]
English, Scientific journal, Although next-generation sequencing-based panel testing is well practiced in the field of cancer medicine for the identification of target molecules in solid tumors, the clinical utility and clinical issues surrounding panel testing in hematological malignancies have yet to be fully evaluated. We conducted a multicenter prospective clinical sequencing study to verify the feasibility of a panel test for hematological tumors, including acute myeloid leukemia, acute lymphoblastic leukemia, multiple myeloma, and diffuse large B-cell lymphoma. Out of 96 eligible patients, 79 patients (82%) showed potentially actionable findings, based on the clinical sequencing assays. We identified that genetic alterations with a strong clinical significance were found at a higher frequency in terms of diagnosis (n = 60; 63%) and prognosis (n = 61; 64%) than in terms of therapy (n = 8; 8%). Three patients who harbored a germline mutation in either DDX41 (n = 2) or BRCA2 (n = 1) were provided with genetic counseling. At 6 mo after sequencing, clinical actions based on the diagnostic (n = 5) or prognostic (n = 3) findings were reported, but no patients were enrolled in a clinical trial or received targeted therapies based on the sequencing results. These results suggest that panel testing for hematological malignancies would be feasible given the availability of useful diagnostic and prognostic information. This study is registered with the UMIN Clinical Trial Registry (UMIN000029879, multiple myeloma; UMIN000031343, adult acute myeloid leukemia; UMIN000033144, diffuse large B-cell lymphoma; and UMIN000034243, childhood leukemia).

Statement on the prevention and treatment of COVID-19 in patients with pediatric cancer in Japan.
Tomoko Iehara, Atsushi Manabe, Hajime Hosoi
Pediatric blood & cancer, 67, 9, e28440, Sep. 2020, [International Magazine]
English

Pulmonary vasodilators can lead to various complications in pulmonary "arterial" hypertension associated with congenital heart disease.
Ayako Chida-Nagai, Koichi Sagawa, Takao Tsujioka, Takanori Fujimoto, Kota Taniguchi, Osamu Sasaki, Gaku Izumi, Hirokuni Yamazawa, Naoki Masaki, Atsushi Manabe, Atsuhito Takeda
Heart and vessels, 35, 9, 1307, 1315, Sep. 2020, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Congenital heart disease-associated pulmonary arterial hypertension (CHD-PAH) is one of the major complications in patients with CHD. A timely closure of the left-to-right shunt will generally result in the normalization of the pulmonary hemodynamics, but a few patients have severe prognosis in their early childhood. We hypothesized that wide-ranging pathological mechanism in PAH could elucidate the clinical state of severe CHD-PAH. Using electronic medical records, we retrospectively analyzed six infants with severe CHD-PAH who had treatment-resistant PH. All patients were born with congenital malformation syndrome. After starting on a pulmonary vasodilator, five of the six patients developed complications including pulmonary edema and interstitial lung disease (ILD), and four patients had alveolar hemorrhage. After steroid therapy, the clinical condition improved in four patients, but two patients died. The autopsy findings in one of the deceased patients indicated the presence of recurrent alveolar hemorrhage, pulmonary venous hypertension, ILD, and PAH. Based on the clinical course of these CHD-PAH in patients and the literature, CHD-PAH can occur with pulmonary vascular obstructive disease (PVOD)/pulmonary capillary hemangiomatosis (PCH), ILD, and/or alveolar hemorrhage. The severity of CHD-PAH may depend on a genetic disorder, respiratory infection, and upper airway stenosis. Additionally, pulmonary vasodilators may be involved in the development of PVOD/PCH and ILD. When patients with CHD-PAH show unexpected deterioration, clinicians should consider complications associated with PVOD/PCH and/or pulmonary disease. In addition, the choice of upfront combination therapy for pediatric patients with CHD-PAH should be selected carefully.

Comparison of child and family reports of health-related quality of life in pediatric acute lymphoblastic leukemia patients after induction therapy.
Shohei Nakajima, Iori Sato, Takafumi Soejima, Katsuyoshi Koh, Motohiro Kato, Yasuhiro Okamoto, Toshihiko Imamura, Miho Maeda, Yasushi Ishida, Atsushi Manabe, Kiyoko Kamibeppu
BMC pediatrics, 20, 1, 390, 390, 19 Aug. 2020, [International Magazine]
English, Scientific journal, BACKGROUND: This study aims at determining the health-related quality of life (HRQOL) of children with acute lymphoblastic leukemia (ALL) after the induction therapy, assessing the agreement between child self-reports and family proxy-reports HRQOL, and determining the factors related to this agreement, especially child age, family attendance, and children's social relationships beyond the family. METHODS: We analyzed questionnaire data (2012-2017) from the Japanese Pediatric Leukemia/Lymphoma Study Group's clinical study (ALL-B12). Participants were children with B-cell precursor ALL aged 5-18 and their family members, who mostly took care of the child during hospitalization. Participants answered the Pediatric Quality of Life Inventory™ (PedsQL™) Generic Core Scales (PedsQL-G), and Cancer Module (PedsQL-C) to measure pediatric HRQOL. We calculated the differences between child self-reported and family proxy-reported subscale scores along with intraclass correlation coefficients (ICC). We conducted multiple regression analyses according to all participant pairs and age groups (young children, school age, and adolescents), with ICCs for all PedsQL-G subscales (ICC-G) and all PedsQL-C subscales (ICC-C) as the outcome variables. RESULTS: Five hundred twenty-two pairs of children and their families were analyzed. We observed a moderate level of agreement on most PedsQL subscales between child self-reports and family proxy-reports; however, worry had the weakest agreement for all PedsQL subscales (ICC = .32, 95% confidence interval = .24-.40). The agreement of ICC-C was positively related to family attendance in the hospitalization, only for the young children group (B = .185, p = .003). CONCLUSIONS: We observed some differences between child self-reports and family proxy-reports of HRQOL of children with ALL. Both child self-reports and family proxy-reports captured HRQOL in the induction therapy. We suggest that attending to young children's hospitalization affects the level of agreement between reports on their HRQOL.

Clinical features of children with polycythemia vera, essential thrombocythemia, and primary myelofibrosis in Japan: A retrospective nationwide survey
Hisashi Ishida, Yuji Miyajima, Nobuyuki Hyakuna, Satoru Hamada, Takeo Sarashina, Risa Matsumura, Katsutsugu Umeda, Tetsuo Mitsui, Naoto Fujita, Daisuke Tomizawa, Kevin Y. Urayama, Yasushi Ishida, Takashi Taga, Masatoshi Takagi, Souichi Adachi, Atsushi Manabe, Toshihiko Imamura, Katsuyoshi Koh, Akira Shimada
eJHaem, 1, 1, 86, 93, Wiley, Jul. 2020
Scientific journal

カテコラミン過剰に伴う症状を契機に診断に至った神経芽腫の1例　　　　　　　　　　　　　　　
橋本 佳帆子, 中山 加奈子, 山口 健史, 原 和也, 寺下 友佳代, 杉山 未奈子, 長 祐子, 井口 晶裕, 本多 昌平, 中村 明枝, 真部 淳
日本小児科学会雑誌, 124, 7, 1156, 1156, (公社)日本小児科学会, Jul. 2020
Japanese

Nationwide study of pediatric B-cell precursor acute lymphoblastic leukemia with chromosome 8q24/MYC rearrangement in Japan.
Kimiyoshi Sakaguchi, Toshihiko Imamura, Sae Ishimaru, Chihaya Imai, Hidemi Shimonodan, Naoto Fujita, Keiko Okada, Takeshi Taketani, Rie Kanai, Hisamichi Tauchi, Motohiro Kato, Yasuko Kojima, Arata Watanabe, Takao Deguchi, Yoshiko Hashii, Nobutaka Kiyokawa, Tomohiko Taki, Akiko M Saito, Keizo Horibe, Atsushi Manabe, Atsushi Sato, Katsuyoshi Koh
Pediatric blood & cancer, 67, 7, e28341, Jul. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Rearrangements of chromosome 8q24/MYC (8q24/MYC-r), resulting from t(8;14)(q24;q32), t(2;8)(p11;q24), or t(8;22)(q24;q11), are mainly associated with Burkitt lymphoma/leukemia (BL) and rarely observed in patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL). The characteristics of BCP-ALL with 8q24/MYC-r are poorly understood. PROCEDURE: A retrospective nationwide study of data from patients with pediatric BCP-ALL with 8q24/MYC-r in Japan was conducted to clarify the clinical and biological characteristics associated with 8q24/MYC-r BCP-ALL. RESULTS: Ten patients with BCP-ALL with 8q24/MYC-r, including three with double-hit leukemia (DHL) (two with t(8;14)(q24;q32) and t(14;18)(q32;q21) and one with t(8;14) and t(3;22)(q27;q11)), were identified. Patients with BCP-ALL with 8q24/MYC-r had higher median age and uric acid and lactate dehydrogenase levels, than those without 8q24/MYC-r. All patients were initially treated with ALL-type chemotherapy; however, four, including one with DHL, were switched to BL-type chemotherapy, based on cytogenetic findings. One patient relapsed after standard-risk ALL-type chemotherapy, and two patients with DHL did not attain complete remission with chemotherapy; all three died within 11 months. The other seven patients treated with BL-type or high-risk ALL-type chemotherapy are alive without disease. CONCLUSIONS: The clinical and laboratory features of BL with IG-MYC rearrangement, displaying a BCP immunophenotype (Wagener et al. and Herbrueggen et al. termed it as pre-BLL), are similar to those of BCP-ALL with 8q24/MYC-r. Low-risk ALL-type chemotherapy may not be appropriate for them, and further studies are required to establish an adequate therapeutic strategy. Further studies of DHL to identify new treatment strategies are also needed.

Refractory malignant hepatocellular tumor consisting of hepatocellular carcinoma and hepatoblastoma in a 10-year-old male
Minako Sugiyama, Shinsuke Hirabayashi, Yukayo Terashita, Yuko Cho, Akihiro Iguchi, Yoshihito Ohhara, Daisuke Abo, Shohei Honda, Emi Takakuwa, Atsushi Manabe
Authorea, Inc., 22 Jun. 2020

Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment.
Ondrej Hrusak, Tomas Kalina, Joshua Wolf, Adriana Balduzzi, Massimo Provenzi, Carmelo Rizzari, Susana Rives, María Del Pozo Carlavilla, Maria E V Alonso, Nerea Domínguez-Pinilla, Jean-Pierre Bourquin, Kjeld Schmiegelow, Andishe Attarbaschi, Pernilla Grillner, Karin Mellgren, Jutte van der Werff Ten Bosch, Rob Pieters, Triantafyllia Brozou, Arndt Borkhardt, Gabriele Escherich, Melchior Lauten, Martin Stanulla, Owen Smith, Allen E J Yeoh, Sarah Elitzur, Ajay Vora, Chi-Kong Li, Hany Ariffin, Alexandra Kolenova, Luciano Dallapozza, Roula Farah, Jelena Lazic, Atsushi Manabe, Jan Styczynski, Gabor Kovacs, Gabor Ottoffy, Maria S Felice, Barbara Buldini, Valentino Conter, Jan Stary, Martin Schrappe
European journal of cancer (Oxford, England : 1990), 132, 11, 16, Jun. 2020, [International Magazine]
English, Scientific journal, INTRODUCTION: Since the beginning of COVID-19 pandemic, it is known that the severe course of the disease occurs mostly among the elderly, whereas it is rare among children and young adults. Comorbidities, in particular, diabetes and hypertension, clearly associated with age, besides obesity and smoke, are strongly associated with the need for intensive treatment and a dismal outcome. A weaker immunity of the elderly has been proposed as a possible explanation of this uneven age distribution. Thus, there is concern that children treated for cancer may allso be at risk for an unfavourable course of infection. Along the same line, anecdotal information from Wuhan, China, mentioned a severe course of COVID-19 in a child treated for leukaemia. AIM AND METHODS: We made a flash survey on COVID-19 incidence and severity among children on anticancer treatment. Respondents were asked by email to fill in a short Web-based survey. RESULTS: We received reports from 25 countries, where approximately 10,000 patients at risk are followed up. At the time of the survey, more than 200 of these children were tested, nine of whom were positive for COVID-19. Eight of the nine cases had asymptomatic to mild disease, and one was just diagnosed with COVID-19. We also discuss preventive measures that are in place or should be taken and treatment options in immunocompromised children with COVID-19. CONCLUSION: Thus, even children receiving anticancer chemotherapy may have a mild or asymptomatic course of COVID-19. While we should not underestimate the risk of developing a more severe course of COVID-19 than that observed here, the intensity of preventive measures should not cause delays or obstructions in oncological treatment.

131 I-MIBG therapy with WT-1 peptide for refractory neuroblastoma.
Minako Sugiyama, Kinuya Seigo, Yosuke Hosoya, Akihiro Iguchi, Atsushi Manabe
Pediatrics international : official journal of the Japan Pediatric Society, 62, 6, 746, 747, 01 Jun. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal

Successful treatment of dumbbell-shaped Hodgkin lymphoma with massive sacral bone destruction.
Minako Sugiyama, Yukayo Terashita, Yuko Cho, Akihiro Iguchi, Ryuta Arai, Emi Takakuwa, Shohei Honda, Atsushi Manabe
Pediatric blood & cancer, 67, 5, e28210, May 2020, [Peer-reviewed], [International Magazine]
English

Nationwide epidemiological survey of familial myelodysplastic syndromes/acute myeloid leukemia in Japan: a multicenter retrospective study.
Kensuke Takaoka, Junji Koya, Akihide Yoshimi, Takashi Toya, Takashi Kobayashi, Yasuhito Nannya, Kumi Nakazaki, Shunya Arai, Hironori Ueno, Kensuke Usuki, Takeshi Yamashita, Daisuke Imanishi, Shinya Sato, Kenshi Suzuki, Hironori Harada, Atsushi Manabe, Yasuhide Hayashi, Yasushi Miyazaki, Mineo Kurokawa
Leukemia & lymphoma, 61, 7, 1, 7, 11 Mar. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, Although several pedigrees of familial myelodysplastic syndromes/acute myeloid leukemia (fMDS/AML) have been reported, the epidemiology and clinical features has been poorly understood. To explore the epidemiology of this entity, we performed a retrospective nationwide epidemiological survey in Japan using questionnaire sheets. The questionnaire was sent to 561 institutions or hospitals certified by Japanese Society of Hematology, unearthing the existence of 41 pedigrees of fMDS/AML. Among them, we obtained the clinical information of 31 patients in 20 pedigrees. The median age of the initial diagnosis was 51 years (range 9-88 years) and the WHO classification 2008 ranged from refractory anemia (RA) to AML. Focusing on the familial MDS patients, refractory anemia with excess blasts (RAEB)-2 was the largest group (27.3%). The median overall survival (OS) of fMDS and fAML in this study were 71.6 and 12.4 months, and the five-year OS were 61.3 and 50%, respectively.

病棟でアデノウイルスによる感染性胃腸炎が発生した際の伝播防止対策に関する検討　　　　　　　　　　　　　　　
石黒 信久, 長 祐子, 井口 晶裕, 杉山 未奈子, 寺下 友佳代, 武田 充人, 真部 淳
日本小児科学会雑誌, 124, 2, 486, 486, (公社)日本小児科学会, Feb. 2020
Japanese

当科における尿細管間質性腎炎ぶどう膜炎症候群症例の臨床的特徴　　　　　　　　　　　　　　　
林 麻子, 佐藤 泰征, 高橋 俊行, 上田 泰弘, 真部 淳, 岡本 孝之
日本小児科学会雑誌, 124, 2, 272, 272, (公社)日本小児科学会, Feb. 2020
Japanese

当院で管理中の先天性門脈体循環シャント6例の検討　　　　　　　　　　　　　　　
辻岡 孝郎, 泉 岳, 武田 充人, 小杉山 清隆, 山澤 弘州, 阿部 二郎, 谷口 宏太, 佐々木 大輔, 永井 礼子, 本多 昌平, 荒 桃子, 阿保 大介, 曽山 武士, 川村 典生, 渡辺 正明, 後藤 了一, 嶋村 剛, 神山 俊哉, 武冨 紹信, 真部 淳
日本小児科学会雑誌, 124, 2, 250, 250, (公社)日本小児科学会, Feb. 2020
Japanese

当院で管理中の先天性門脈体循環シャント6例の検討　　　　　　　　　　　　　　　
辻岡 孝郎, 泉 岳, 武田 充人, 小杉山 清隆, 山澤 弘州, 阿部 二郎, 谷口 宏太, 佐々木 大輔, 永井 礼子, 本多 昌平, 荒 桃子, 阿保 大介, 曽山 武士, 川村 典生, 渡辺 正明, 後藤 了一, 嶋村 剛, 神山 俊哉, 武冨 紹信, 真部 淳
日本小児科学会雑誌, 124, 2, 250, 250, (公社)日本小児科学会, Feb. 2020
Japanese

小児科スタッフが中高生以上のがん患者と関わる上で抱えている課題に関する質問紙調査
半谷 まゆみ, 関 正史, 三谷 友一, 樋渡 光輝, 岩崎 美和, 木村 敬子, 副島 尭史, 佐藤 伊織, 松本 公一, 康 勝好, 真部 淳, 高木 正稔, 藤村 純也, 滝田 順子
日本小児血液・がん学会雑誌, 56, 5, 447, 453, (一社)日本小児血液・がん学会, Feb. 2020, [Peer-reviewed]
Japanese

Immune thrombocytopenia in a case of trisomy 18
Minako Sugiyama, Yukayo Terashita, Atsuhito Takeda, Akihiro Iguchi, Atsushi Manabe
PEDIATRICS INTERNATIONAL, 62, 2, 240, 242, Feb. 2020, [Peer-reviewed]
English, Scientific journal

Relationship between Sedative Antihistamines and the Duration of Febrile Seizures.
Atsuro Daida, Gaku Yamanaka, Shin-Ichi Tsujimoto, Mina Yokoyama, Kuniyoshi Hayashi, Kevin Y Urayama, Yasushi Ishida, Atsushi Manabe, Isao Kusakawa, Masaaki Ogihara, Hisashi Kawashima
Neuropediatrics, 51, 2, 154, 159, 14 Jan. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, Some studies have shown that sedative antihistamines prolong febrile seizure duration. Although the collective evidence is still mixed, the Japanese Society of Child Neurology released guidelines in 2015 that contraindicated the use of sedative antihistamines in patients with febrile seizure. Focused on addressing limitations of previous studies, we conducted a cross-sectional study to evaluate the relationship between febrile seizure duration and the use of sedative antihistamines. Data were collected from patients who visited St. Luke's International Hospital due to febrile seizure between August 2013 and February 2016. Patients were divided into groups based on their prescribed medications: sedative antihistamine, nonsedative antihistamine, and no antihistamine. Seizure duration was the primary outcome and was examined using multivariate analyses. Of the 426 patients included, sedative antihistamines were administered to 24 patients. The median seizure duration was approximately 3 minutes in all three groups. There was no statistical difference in the bivariate (p = 0.422) or multivariate analyses (p = 0.544). Our results do not support the relationship between sedative antihistamine use and prolonged duration of febrile seizure. These results suggest that the use of antihistamines may be considered for patients with past history of febrile seizure, when appropriate.

褐色細胞腫との鑑別を要した神経芽腫の2歳女児例
山口 健史, 中村 明枝, 中山 加奈子, 菱村 希, 橋本 佳帆子, 長 祐子, 本多 昌平, 真部 淳
日本内分泌学会雑誌, 95, 3, 873, 873, (一社)日本内分泌学会, Jan. 2020
Japanese

Corticosteroid-induced glaucoma in pediatric patients with hematological malignancies.
Minako Sugiyama, Yukayo Terashita, Kazuya Hara, Yuko Cho, Akihiro Iguchi, Shinki Chin, Atsushi Manabe
Pediatric blood & cancer, 66, 12, e27977, Dec. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Corticosteroids, especially dexamethasone, play a critical role in chemotherapy for pediatric hematological malignancies. We previously observed that patients with complaints of headache or photophobia during corticosteroid administration had high intraocular pressure (IOP). PROCEDURE: We measured IOP during corticosteroid administration in 15 patients with acute leukemia or lymphoma undergoing treatment at our institution from January 2016 to December 2018. IOP was measured by an ophthalmologist within seven days of the initiation of standard dose of corticosteroid, which was defined as 60 mg/m2 /day for prednisolone and 10 mg/m2 /day for dexamethasone. RESULTS: Fifteen patients received 52 courses of chemotherapy containing corticosteroids. IOP exceeded 21 mmHg among 13 patients in 28 courses. Twelve of the 13 patients were administered topical treatment, and six of the 12 patients needed additional diuretic agents. IOP during the chemotherapy courses containing dexamethasone was significantly higher compared with IOP during the chemotherapy courses containing prednisolone. Only two patients complained of symptoms, such as headache and photophobia, and one of the two patients underwent trabeculotomy. Funduscopic findings were normal in all patients. There was a dose-associated decrease in IOP with reduction of dexamethasone dose. CONCLUSIONS: IOP should be measured during administration of substantial corticosteroid doses even in patients with no symptoms. Further investigations regarding the level of IOP for intervention need to be conducted.

DNA methylation-based classification reveals difference between pediatric T-cell acute lymphoblastic leukemia and normal thymocytes.
Shunsuke Kimura, Masafumi Seki, Tomoko Kawai, Hiroaki Goto, Kenichi Yoshida, Tomoya Isobe, Masahiro Sekiguchi, Kentaro Watanabe, Yasuo Kubota, Yasuhito Nannya, Hiroo Ueno, Yusuke Shiozawa, Hiromichi Suzuki, Yuichi Shiraishi, Kentaro Ohki, Motohiro Kato, Katsuyoshi Koh, Ryoji Kobayashi, Takao Deguchi, Yoshiko Hashii, Toshihiko Imamura, Atsushi Sato, Nobutaka Kiyokawa, Atsushi Manabe, Masashi Sanada, Marc R Mansour, Akira Ohara, Keizo Horibe, Masao Kobayashi, Akira Oka, Yasuhide Hayashi, Satoru Miyano, Kenichiro Hata, Seishi Ogawa, Junko Takita
Leukemia, 34, 4, 1163, 1168, 15 Nov. 2019, [Peer-reviewed], [International Magazine]
English

Bortezomib-containing therapy in Japanese children with relapsed acute lymphoblastic leukemia.
Daisuke Hasegawa, Yuri Yoshimoto, Shunsuke Kimura, Tadashi Kumamoto, Naoko Maeda, Junichi Hara, Atsushi Kikuta, Akiko Kada, Toshimi Kimura, Yuka Iijima-Yamashita, Akiko M Saito, Keizo Horibe, Atsushi Manabe, Chitose Ogawa
International journal of hematology, 110, 5, 627, 634, Nov. 2019, [Domestic magazines]
English, Scientific journal, Outcomes of children treated for relapsed acute lymphoblastic leukemia (ALL) remain poor. Bortezomib (BZM), a proteasome inhibitor, has shown promising activity against lymphoid malignancies. We conducted a phase I study to evaluate the safety and tolerability of multidrug chemotherapy including BZM in Japanese children with relapsed ALL. Three of five children with relapsed ALL enrolled in the study between November 2014 and April 2016 were evaluated. BZM (1.3 mg/m2) was administered on days 8, 11, 15, and 18 of multidrug induction chemotherapy. Pharmacokinetic studies were performed. Age at study entry was 5, 7, and 7 years old, respectively. Two patients had hyperdiploid B-precursor ALL, and one had T cell ALL. Although all patients experienced grade 3-4 hematologic toxicity and grade 3 elevation of aminotransferases, no dose-limiting toxicities were observed. The maximum tolerated dose was defined as 1.3 mg/m2. Peripheral neuropathy and respiratory complications were not observed. Complete remission was achieved in all three patients. The mean maximum plasma concentration and area under the concentration-time curve was 74.0 ng/mL and 73.9 ng h/mL, respectively. Thus, adding BZM to 5-drug induction chemotherapy appears safe and well-tolerated in Japanese children with relapsed ALL.

Very late relapse cases of TCF3-ZNF384-positive acute lymphoblastic leukemia.
Akira Nishimura, Daisuke Hasegawa, Shinsuke Hirabayashi, Shoichiro Kanabuchi, Kaoru Yamamoto, Saori Aiga, Misa Nishitani, Yosuke Hosoya, Yasushi Noguchi, Kentaro Ohki, Nobutaka Kiyokawa, Shinichiro Mori, Atsushi Manabe
Pediatric blood & cancer, 66, 11, e27891, Nov. 2019, [Peer-reviewed], [International Magazine]
English

Nationwide survey of pediatric hypodiploid acute lymphoblastic leukemia in Japan.
Sae Ishimaru, Yasuhiro Okamoto, Chihaya Imai, Hirotoshi Sakaguchi, Tomohiko Taki, Daisuke Hasegawa, Yuko Cho, Harumi Kakuda, Hideki Sano, Atsushi Manabe, Toshihiko Imamura, Motohiro Kato, Yuki Arakawa, Hidemi Shimonodan, Atsushi Sato, Souichi Suenobu, Takeshi Inukai, Arata Watanabe, Yoshifumi Kawano, Atsushi Kikuta, Keizo Horibe, Akira Ohara, Katsuyoshi Koh
Pediatrics international : official journal of the Japan Pediatric Society, 61, 11, 1103, 1108, Nov. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Ploidy is a highly significant prognostic factor for pediatric acute lymphoblastic leukemia (ALL). Children with hypodiploid ALL have poor outcomes despite current intensive chemotherapy. Little has been investigated with regard to hypodiploid ALL in Japanese children. METHODS: We retrospectively collected clinical data on hypodiploid ALL cases from the registries of prospective multicenter trials conducted by the four independent clinical study groups in Japan between 1997 and 2012. RESULTS: A total of 117 ALL patients with hypodiploidy were analyzed in this study. There were 101, eight, and eight patients with 45, 44, and fewer than 44 chromosomes, respectively. The 5 year overall survival rates differed significantly: 86.0%, 87.5%, and 62.5% for patients with 45, 44, and fewer than 44 chromosomes, respectively (P = 0.037). Of the eight patients with 44 chromosomes, seven were alive, including five patients who maintained complete remission without undergoing hematopoietic stem cell transplantation (HSCT). Of the eight patients with fewer than 44 chromosomes, six were good responders to prednisolone and none had induction failure, but the relapse rate was high (5/8). No patients had central nervous system relapse. Four patients underwent HSCT after relapse, but only one survived. CONCLUSIONS: Outcomes of Japanese ALL patients with fewer than 44 chromosomes were poor, as previously reported in other countries. Although the sample size was small, patients with 44 chromosomes had better prognoses than those previously reported. Further studies including international collaboration are needed to improve outcomes for pediatric ALL patients with fewer than 44 chromosomes.

【2019年の白血病診療-新たな武器を上手に活用するために】フィラデルフィア染色体様(Ph-like)急性リンパ性白血病の診断と治療
小野 林太郎, 真部 淳
内科, 124, 4, 2167, 2169, (株)南江堂, Oct. 2019
Japanese

Germline GATA2変異を伴う骨髄異形成症候群(MDS)の1例　　　　　　　　　　　　　　　
水城 和義, 平林 真介, 長谷川 大輔, 山本 俊亮, 山本 薫, 足洗 美穂, 小野 林太郎, 細谷 要介, 鈴木 美慧, 松本 公宏, 川口 裕之, 真部 淳
臨床血液, 60, 10, 1502, 1502, (一社)日本血液学会-東京事務局, Oct. 2019
Japanese

長期にわたる免疫抑制治療後にステロイド離脱が可能となった移植後自己免疫性溶血性貧血(AIHA)　　　　　　　　　　　　　　　
小野 林太郎, 細谷 要介, 山本 俊亮, 山本 薫, 西村 聡, 足洗 美穂, 平林 真介, 長谷川 大輔, 真部 淳
日本小児血液・がん学会雑誌, 56, 4, 324, 324, (一社)日本小児血液・がん学会, Oct. 2019
Japanese

ウィリアムズ症候群を背景に発症したバーキットリンパ腫　　　　　　　　　　　　　　　
長谷河 昌孝, 長 祐子, 原 和也, 寺下 友佳代, 杉山 未奈子, 大久保 淳, 井口 晶裕, 真部 淳, 荒 桃子, 本多 昌平, 武冨 紹信, 高桑 恵美, 松野 吉宏
日本小児血液・がん学会雑誌, 56, 4, 299, 299, (一社)日本小児血液・がん学会, Oct. 2019, [Peer-reviewed]
Japanese

Pediatric patients with cancer predisposition in Japan: Results of a questionnaire survey.
Yoshiko Nakano, Yukiko Tsunematsu, Fumito Yamazaki, Atsushi Manabe, Akira Nakagawara, Eiso Hiyama, Tadashi Kumamoto
Pediatric blood & cancer, 66, 10, e27937, Oct. 2019, [Peer-reviewed], [International Magazine]
English

過去10年間に当院外来を受診した異物誤飲の小児患者に関する検討　　　　　　　　　　　　　　　
山本 俊亮, 島袋 林秀, 梅原 直, 右田 美里, 平田 倫生, 小澤 美和, 真部 淳, 松藤 凡, 草川 功
日本小児救急医学会雑誌, 18, 3, 343, 347, (一社)日本小児救急医学会, Oct. 2019, [Peer-reviewed]
Japanese

Break Apart FISH Probeで転座判定に苦慮したKMT2A-MLLT10 mRNA陽性AMLの一症例
小栗 聡, 佐藤 かおり, 市川 絢子, 藤澤 真一, 原 和也, 杉山 未奈子, 寺下 友佳代, 長 祐子, 井口 晶裕, 杉田 純一, 西田 睦, 豊嶋 崇徳, 真部 淳
日本染色体遺伝子検査学会雑誌, 37, 2, 47, 47, 日本染色体遺伝子検査学会, Sep. 2019
Japanese

Efficacy of the NCCV Cocktail‐1 vaccine for refractory pediatric solid tumors: a phase I clinical trial
Akazawa Y, Hosono A, Yoshikawa T, Kaneda H, Nitani C, Hara J, Kinoshita Y, Kohashi K, Manabe A, Fukutani M, Wakabayashi M, Sato A, Shoda K, Shimomura M, Mizuno S, Nakamoto Y, Nakatsura T
Cancer Science, 110, 12, 3650, 3662, Wiley, Sep. 2019, [Peer-reviewed]
Scientific journal

A germline HLTF mutation in familial MDS induces DNA damage accumulation through impaired PCNA polyubiquitination.
Kensuke Takaoka, Masahito Kawazu, Junji Koya, Akihide Yoshimi, Yosuke Masamoto, Hiroaki Maki, Takashi Toya, Takashi Kobayashi, Yasuhito Nannya, Shunya Arai, Toshihide Ueno, Hironori Ueno, Kenshi Suzuki, Hironori Harada, Atsushi Manabe, Yasuhide Hayashi, Hiroyuki Mano, Mineo Kurokawa
Leukemia, 33, 7, 1773, 1782, Jul. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Although several causal genes of familial myelodysplastic syndromes (MDS) have been identified, the genetic landscape and the molecular pathogenesis are not totally understood. To explore novel driver genes and their pathogenetic significance, we performed whole-exome sequence analysis of four individuals from a familial MDS pedigree and 10 candidate single-nucleotide variants (C9orf43, CYP7B1, EFHB, ENTPD7, FAM160B2, HELZ2, HLTF, INPP5J, ITPKB, and RYK) were identified. Knockdown screening revealed that Hltf downregulation enhanced colony-forming capacity of primary murine bone marrow (BM) stem/progenitor cells. γH2AX immunofluorescent staining assay revealed increased DNA damage in a human acute myeloid leukemia (AML) cell line ectopically expressing HLTF E259K, which was not observed in cells expressing wild-type HLTF. Silencing of HLTF in human AML cells also led to DNA damage, indicating that HLTF E259K is a loss-of-function mutation. Molecularly, we found that an E259K mutation reduced the binding capacity of HLTF with ubiquitin-conjugating enzymes, methanesulfonate sensitive 2 and ubiquitin-conjugating enzyme E2N, resulting in impaired polyubiquitination of proliferating cell nuclear antigen (PCNA) in HLTF E259K-transduced cells. In summary, our results indicate that a familial MDS-associated HLTF E259K germline mutation induces accumulation of DNA double-strand breaks, possibly through impaired PCNA polyubiquitination.

Kawasaki disease shock syndrome: Case report and cytokine profiling.
Ono R, Shimizu M, Yamamoto K, Umehara N, Manabe A
Pediatrics international : official journal of the Japan Pediatric Society, 61, 6, 620, 622, Jun. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal

Dasatinib and low-intensity chemotherapy for Philadelphia chromosome-positive acute lymphoblastic leukemia in a child with Down syndrome.
Shinsuke Hirabayashi, Daisuke Hasegawa, Kaoru Yamamoto, Akira Nishimura, Yosuke Hosoya, Takuya Shuo, Nobutaka Kiyokawa, Masatomo Miura, Naoto Takahashi, Atsushi Manabe
Pediatric blood & cancer, 66, 5, e27612, May 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal

Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study.
Miyamura T, Moritake H, Nakayama H, Tanaka S, Tomizawa D, Shiba N, Saito AM, Tawa A, Shimada A, Iwamoto S, Hayashi Y, Koike T, Horibe K, Manabe A, Mizutani S, Taga T, Adachi S
British journal of haematology, 185, 2, 284, 288, Apr. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. The 3-year overall survival rate of the 41 PIF patients was 19.0%. High leucocyte count, M7 morphology, and unfavourable genetic aberrations, such as FLT3-internal tandem duplication, NUP98-NSD1 and high MECOM or PRDM16 expression, were risk factors for PIF. More effective treatment strategies based on leukaemia biology need to be urgently explored.

画像診断 今月の症例 心膜外脂肪壊死(epipericardial fat necrosis:EFN)
佐藤 崇翔, 野崎 太希, 松迫 正樹, 真部 淳, 宮嵜 治
小児科臨床, 72, 3, 233, 236, (株)日本小児医事出版社, Mar. 2019
Japanese

小児急性リンパ性白血病における高用量メトトレキサート投与時の薬物動態解析　　　　　　　　　　　　　　　
田中 庸一, 浦山 ケビン, 森 麻希子, 長谷川 大輔, 赤羽 弘資, 太田 節雄, 真部 淳
日本薬学会年会要旨集, 139年会, 4, 65, 65, (公社)日本薬学会, Mar. 2019, [Peer-reviewed]
Japanese

川崎病急性期に急性腎不全,顕性黄疸,低酸素血症,低血圧を合併した10歳女児の1例
小野林太郎, 山本俊亮, 山本薫, 梅原直, 清水正樹, 谷内江昭宏, 真部淳
心臓, 51, 3, 365, 366, (公財)日本心臓財団, Mar. 2019
Japanese, Scientific journal

Duplication of ALK F1245 missense mutation due to acquired uniparental disomy associated with aggressive progression in a patient with relapsed neuroblastoma.
Shunsuke Kimura, Daisuke Hasegawa, Yuri Yoshimoto, Masafumi Seki, Atsuro Daida, Masahiro Sekiguchi, Shinsuke Hirabayashi, Yosuke Hosoya, Masao Kobayashi, Satoru Miyano, Seishi Ogawa, Junko Takita, Atsushi Manabe
Oncology letters, 17, 3, 3323, 3329, Mar. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Recent genome-wide analysis of neuroblastoma (NBL) revealed amplification and heterozygous mutation of anaplastic lymphoma kinase (ALK) are responsible for oncogenicity, frequently observed during relapses. A 3-year-old girl with relapsed high-risk NBL had a heterozygous ALK F1245L mutation at diagnosis, which became homozygous due to uniparental disomy (UPD) of the entire chromosome 2, confirmed by single nucleotide polymorphism array and variant allele frequency of this mutation. The ALK inhibitor, crizotinib, failed to control the tumor and the patient died of the disease. Further genomic analysis using targeted capture sequencing for 381 genes related to pediatric cancers identified more alterations acquired at relapse, such as TSC complex subunit 2 and protein tyrosine phosphatase receptor type D. In addition to these several acquired mutations, this extremely rare duplication of ALK mutation might explain the aggressive clinical course after relapse, because acquired UPD, resulting in the duplication of an oncogenic mutation, has been reported for various neoplasms. Although a clinical benefit of ALK inhibitors in patients with NBL has not been confirmed yet, a treatment based on the ALK mutation status will be promising in future using more potent next-generation ALK inhibitors.

腸管気腫を来した血液腫瘍性疾患・原発性免疫不全症の5例　　　　　　　　　　　　　　　
西村 聡, 足洗 美穂, 神谷 尚宏, 山本 俊亮, 山本 薫, 友田 昂宏, 井上 真依子, 井上 健斗, 宮本 智史, 小野 林太郎, 平林 真介, 磯田 健志, 柳町 昌克, 細谷 要介, 長谷川 大輔, 今井 耕輔, 高木 正稔, 金兼 弘和, 真部 淳, 森尾 友宏
日本小児科学会雑誌, 123, 2, 273, 273, (公社)日本小児科学会, Feb. 2019
Japanese

寛解導入療法中に肺胞出血をきたしNO吸入療法が有効であったAMLの1例　　　　　　　　　　　　　　　
足洗 美穂, 梅原 直, 黒子 由梨香, 山本 薫, 山本 俊亮, 小野 林太郎, 平林 真介, 細谷 要介, 長谷川 大輔, 真部 淳
日本小児科学会雑誌, 123, 2, 320, 320, (公社)日本小児科学会, Feb. 2019
Japanese

Pediatric oncologic emergencies: Clinical and imaging review for pediatricians.
Atsuhiko Handa, Taiki Nozaki, Akari Makidono, Tetsuhiko Okabe, Yuka Morita, Kazutoshi Fujita, Masaki Matsusako, Tatsuo Kono, Yasuyuki Kurihara, Daisuke Hasegawa, Tadashi Kumamoto, Chitose Ogawa, Yuki Yuza, Atsushi Manabe
Pediatrics international : official journal of the Japan Pediatric Society, 61, 2, 122, 139, Feb. 2019, [International Magazine]
English, Scientific journal, Children with cancer are at increased risk of life-threatening emergencies, either from the cancer itself or related to the cancer treatment. These conditions need to be assessed and treated as early as possible to minimize morbidity and mortality. Cardiothoracic emergencies encompass a variety of pathologies, including pericardial effusion and cardiac tamponade, massive hemoptysis, superior vena cava syndrome, pulmonary embolism, and pneumonia. Abdominal emergencies include bowel obstruction, intussusception, perforation, tumor rupture, intestinal graft-versus-host disease, acute pancreatitis, neutropenic colitis, and obstructive uropathy. Radiology plays a vital role in the diagnosis of these emergencies. We here review the clinical features and imaging in pediatric patients with oncologic emergencies, including a review of recently published studies. Key radiological images are presented to highlight the radiological approach to diagnosis. Pediatricians, pediatric surgeons, and pediatric radiologists need to work together to arrive at the correct diagnosis and to ensure prompt and appropriate treatment strategies.

NOTCH1 pathway activating mutations and clonal evolution in pediatric T-cell acute lymphoblastic leukemia.
Kimura S, Seki M, Yoshida K, Shiraishi Y, Akiyama M, Koh K, Imamura T, Manabe A, Hayashi Y, Kobayashi M, Oka A, Miyano S, Ogawa S, Takita J
Cancer science, 110, 2, 784, 794, Feb. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Molecular mechanisms involved in the relapse of T-cell acute lymphoblastic leukemia (T-ALL) are not fully understood, although activating NOTCH1 signaling due to NOTCH1/FBXW7 alterations is a major oncogenic driver. To unravel the relevance of NOTCH1/FBXW7 mutations associated with relapse, we performed whole-exome sequencing in 30 pediatric T-ALL cases, among which 11 diagnosis-relapse paired cases were further investigated to track the clonal evolution of relapse using amplicon-based deep sequencing. NOTCH1/FBXW7 alterations were detected in 73.3% (diagnosis) and 72.7% (relapse) of cases. Single nucleotide variations in the heterodimerization domain were the most frequent (40.0%) at diagnosis, whereas proline, glutamic acid, serine, threonine-rich (PEST) domain alterations were the most frequent at relapse (54.5%). Comparison between non-relapsed and relapsed cases at diagnosis showed a predominance of PEST alterations in relapsed cases (P = .045), although we failed to validate this in the TARGET cohort. Based on the clonal analysis of diagnosis-relapse samples, we identified NOTCH1 "switching" characterized by different NOTCH1 mutations in a major clone between diagnosis and relapse samples in 2 out of 11 diagnosis-relapse paired cases analyzed. We found another NOTCH1 "switching" case in a previously reported Berlin-Frankfurt-Münster cohort (n = 13), indicating NOTCH1 importance in both the development and progression of T-ALL. Despite the limitations of having a small sample size and a non-minimal residual disease-based protocol, our results suggest that the presence of NOTCH1 mutations might contribute to the disease relapse of T-ALL.

Diamond-Blackfan貧血に対する強度減弱前処置を用いた骨髄移植
西村 聡, 平林 真介, 山本 俊亮, 相賀 咲央莉, 西谷 美佐, 細谷 要介, 森 慎一郎, 長谷川 大輔, 真部 淳
日本小児血液・がん学会雑誌, 55, 5, 432, 435, (一社)日本小児血液・がん学会, Jan. 2019
Japanese

Clinical and molecular characteristics of MEF2D fusion-positive B-cell precursor acute lymphoblastic leukemia in childhood, including a novel translocation resulting in MEF2D-HNRNPH1 gene fusion.
Kentaro Ohki, Nobutaka Kiyokawa, Yuya Saito, Shinsuke Hirabayashi, Kazuhiko Nakabayashi, Hitoshi Ichikawa, Yukihide Momozawa, Kohji Okamura, Ai Yoshimi, Hiroko Ogata-Kawata, Hiromi Sakamoto, Motohiro Kato, Keitaro Fukushima, Daisuke Hasegawa, Hiroko Fukushima, Masako Imai, Ryosuke Kajiwara, Takashi Koike, Isao Komori, Atsushi Matsui, Makiko Mori, Koichi Moriwaki, Yasushi Noguchi, Myoung-Ja Park, Takahiro Ueda, Shohei Yamamoto, Koichi Matsuda, Teruhiko Yoshida, Kenji Matsumoto, Kenichiro Hata, Michiaki Kubo, Yoichi Matsubara, Hiroyuki Takahashi, Takashi Fukushima, Yasuhide Hayashi, Katsuyoshi Koh, Atsushi Manabe, Akira Ohara
Haematologica, 104, 1, 128, 137, Jan. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Fusion genes involving MEF2D have recently been identified in precursor B-cell acute lymphoblastic leukemia, mutually exclusive of the common risk stratifying genetic abnormalities, although their true incidence and associated clinical characteristics remain unknown. We identified 16 cases of acute lymphoblastic leukemia and 1 of lymphoma harboring MEF2D fusions, including MEF2D-BCL9 (n=10), MEF2D-HNRNPUL1 (n=6), and one novel MEF2D-HNRNPH1 fusion. The incidence of MEF2D fusions overall was 2.4% among consecutive precursor B-cell acute lymphoblastic leukemia patients enrolled onto a single clinical trial. They frequently showed a cytoplasmic μ chain-positive pre-B immunophenotype, and often expressed an aberrant CD5 antigen. Besides up- and down-regulation of HDAC9 and MEF2C, elevated GATA3 expression was also a characteristic feature of MEF2D fusion-positive patients. Mutations of PHF6, recurrent in T-cell acute lymphoblastic leukemia, also showed an unexpectedly high frequency (50%) in these patients. MEF2D fusion-positive patients were older (median age 9 years) with elevated WBC counts (median: 27,300/ml) at presentation and, as a result, were mostly classified as NCI high risk. Although they responded well to steroid treatment, MEF2D fusion-positive patients showed a significantly worse outcome, with 53.3% relapse and subsequent death. Stem cell transplantation was ineffective as salvage therapy. Interestingly, relapse was frequently associated with the presence of CDKN2A/CDKN2B gene deletions. Our observations indicate that MEF2D fusions comprise a distinct subgroup of precursor B-cell acute lymphoblastic leukemia with a characteristic immunophenotype and gene expression signature, associated with distinct clinical features.

Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms.
Shinichi Tsujimoto, Tomoo Osumi, Meri Uchiyama, Ryota Shirai, Takaya Moriyama, Rina Nishii, Yuji Yamada, Ko Kudo, Masahiro Sekiguchi, Yuki Arakawa, Masanori Yoshida, Toru Uchiyama, Kiminori Terui, Shuichi Ito, Katsuyoshi Koh, Junko Takita, Etsuro Ito, Daisuke Tomizawa, Atsushi Manabe, Nobutaka Kiyokawa, Jun J Yang, Motohiro Kato
Leukemia, 32, 12, 2710, 2714, Dec. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal

Sequential use of second-generation tyrosine kinase inhibitors following imatinib therapy in pediatric chronic myeloid leukemia: A report from the Japanese Pediatric Leukemia/Lymphoma Study Group.
Hidemitsu Kurosawa, Akihiko Tanizawa, Hideki Muramatsu, Chikako Tono, Akihiro Watanabe, Haruko Shima, Masaki Ito, Yuki Yuza, Kazuko Hamamoto, Noriko Hotta, Masahiko Okada, Akiko Moriya Saito, Atsushi Manabe, Shuki Mizutani, Souichi Adachi, Keizo Horibe, Eiichi Ishii, Hiroyuki Shimada
Pediatric blood & cancer, 65, 12, e27368, Dec. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: The details of the sequential use of imatinib for first-line treatment followed by second-generation tyrosine kinase inhibitors (2G-TKIs) for pediatric chronic myeloid leukemia (CML) are still unknown. This study analyzed clinical responses and adverse effects of the use of 2G-TKIs following imatinib in pediatric chronic phase (CP)-CML. PROCEDURES: The Japanese Pediatric Leukemia/Lymphoma Study Group conducted a retrospective study of patients with newly diagnosed CML from 1996 to 2011. A total of 152 cases that received imatinib as first-line therapy were analyzed. RESULTS: Excluding 46 cases treated with hematopoietic stem cell transplantation before nilotinib and dasatinib became available, 31 of 106 patients changed to 2G-TKIs. The primary reason for changing from imatinib was poor response, followed by intolerance, with the main reason for the latter being musculoskeletal events. Switches from imatinib to 2G-TKIs with intolerance occurred significantly earlier than switches with poor response. Sixteen and 15 patients were treated with nilotinib and dasatinib, respectively, following imatinib therapy. After switching to 2G-TKIs, the response status improved in 63% of evaluable patients. The adverse effect profiles of nilotinib and dasatinib tended to be different, with hyperbilirubinemia observed in 33% of nilotinib-treated patients, but in none of the cases with dasatinib. CONCLUSION: This retrospective study represents the first series of children and adolescents in whom sequential use of imatinib followed by 2G-TKIs was reported. These data provide useful insights into the selection of 2G-TKIs as first-line treatment for children and adolescents with CP-CML.

Regional evaluation of childhood acute lymphoblastic leukemia genetic susceptibility loci among Japanese
Kevin Y. Urayama, Masatoshi Takagi, Takahisa Kawaguchi, Keitaro Matsuo, Yoichi Tanaka, Yoko Ayukawa, Yuki Arakawa, Daisuke Hasegawa, Yuki Yuza, Takashi Kaneko, Yasushi Noguchi, Yuichi Taneyama, Setsuo Ota, Takeshi Inukai, Masakatsu Yanagimachi, Dai Keino, Kazutoshi Koike, Daisuke Toyama, Yozo Nakazawa, Hidemitsu Kurosawa, Kozue Nakamura, Koichi Moriwaki, Hiroaki Goto, Yujin Sekinaka, Daisuke Morita, Motohiro Kato, Junko Takita, Toshihiro Tanaka, Johji Inazawa, Katsuyoshi Koh, Yasushi Ishida, Akira Ohara, Shuki Mizutani, Fumihiko Matsuda, Atsushi Manabe
Scientific Reports, 8, 1, 789, Nature Publishing Group, 01 Dec. 2018, [Peer-reviewed]
English, Scientific journal

Clinical and Genetic Characteristics of Patients with Shwachman-Diamond Syndrome in Japan
Watanabe Kenichiro, Kanegane Hirokazu, Hamabata Takayuki, Kozuki Kagehiro, Umeda Katsutsugu, Ueno Hiroo, Yoshida Kenichi, Hama Asahito, Okuno Yusuke, Muramatsu Hideki, Takahashi Yoshiyuki, Hasegawa Daisuke, Manabe Atsushi, Ohara Akira, Ito Masafumi, Ogawa Seishi, Kojima Seiji, Ito Etsuro
BLOOD, 132, 29 Nov. 2018
English, Scientific journal

Diagnosis of Inherited Bone Marrow Failure Syndromes Using Sequencing Approaches　　　　　　　　　　　　　　　
Narita Atsushi, Muramatsu Hideki, Okuno Yusuke, Yoshida Kenichi, Shiraishi Yuichi, Sakaguchi Hirotoshi, Kawashima Nozomu, Wang Xinan, Xu Yinyan, Chiba Kenichi, Tanaka Hiroko, Hama Asahito, Sanada Masashi, Hitoshi Kanno, Yamaguchi Hiroki, Ohga Shouichi, Manabe Atsushi, Harigae Hideo, Kunishima Shinji, Ishii Eiichi, Kobayashi Masao, Koike Kenichi, Watanabe Kenichiro, Ito Etsuro, Takata Minoru, Yabe Miharu, Ogawa Seishi, Miyano Satoru, Kojima Seiji, Takahashi Yoshiyuki
PEDIATRIC BLOOD & CANCER, 65, S7-S7, Nov. 2018
English, Scientific journal

Treatment Outcome of Children with Acute Lymphoblastic Leukemia Harbouring Newly Identified Genetic Abnormalities: Results from TCCSG Study L04-16
Ohki Kentaro, Kiyokawa Nobutaka, Takahashi Hiroyuki, Kajiwara Ryosuke, Kato Motohiro, Hasegawa Daisuke, Tomizawa Daisuke, Noguchi Yasushi, Koike Kazutoshi, Toyama Daisuke, Yabe Hiromasa, Michiko Kajiwara, Fujimura Junya, Sotomatsu Manabu, Ota Setsuo, Maeda Miho, Goto Hiroaki, Kato Yoko, Mori Tetsuya, Inukai Takeshi, Shimada Hiroyuki, Fukushima Keitaro, Ogawa Chitose, Fukushima Takashi, Koh Katsuyoshi, Manabe Atsushi, Ohara Akira
PEDIATRIC BLOOD & CANCER, 65, S7, S8, Nov. 2018, [Peer-reviewed]
English

Morphological Features of Bone Marrow in Patients with Inherited Bone Marrow Failure　　　　　　　　　　　　　　　
Hama Asahito, Hasegawa Daisuke, Manabe Atsushi, Nozawa Kazue, Narita Atsushi, Okuno Yusuke, Muramatsu Hideki, Takahashi Yoshiyuki, Watanabe Kenichiro, Ohara Akira, Ito Masafumi, Kojima Seiji
PEDIATRIC BLOOD & CANCER, 65, S66-S66, Nov. 2018
English, Scientific journal

-7が生じたPearson症候群に対する移植経験
西村 聡, 平林 真介, 山本 俊亮, 山本 一希, 山本 薫, 相賀 咲央莉, 代田 惇朗, 足洗 美穂, 細谷 要介, 藤原 亨, 張替 秀郎, 森 愼一郎, 長谷川 大輔, 真部 淳
日本小児血液・がん学会雑誌, 55, 3, 334, 335, (一社)日本小児血液・がん学会, Oct. 2018
Japanese

Clinical characteristics of pediatric patients with myeloid sarcoma without bone marrow involvement in Japan.
Taga T, Imamura T, Nakashima K, Maeda N, Watanabe A, Miyajima Y, Sakaguchi S, Sano H, Hasegawa D, Kawasaki H, Adachi S, Takagi M, Koh K, Manabe A, Taki T, Ishida Y
International journal of hematology, 108, 4, 438, 442, Oct. 2018, [Peer-reviewed]
Scientific journal

シーケンスによる先天性骨髄不全症の診断(Diagnosis of Inherited Bone Marrow Failure Syndromes Using Sequencing Approaches)
Narita Atsushi, Muramatsu Hideki, Okuno Yusuke, Yoshida Kenichi, Shiraishi Yuichi, Sakaguchi Hirotoshi, Kawashima Nozomu, Wang Xinan, Xu Yinyan, Chiba Kenichi, Tanaka Hiroko, Hama Asahito, Sanada Masashi, Kanno Hitoshi, Yamaguchi Hiroki, Ohga Shouichi, Manabe Atsushi, Harigae Hideo, Kunishima Shinji, Ishii Eiichi, Kobayashi Masao, Koike Kenichi, Watanabe Kenichiro, Ito Etsuro, Takata Minoru, Yabe Miharu, Ogawa Seishi, Miyano Satoru, Kojima Seiji, Takahashi Yoshiyuki
日本小児血液・がん学会雑誌, 55, 4, 153, 153, (一社)日本小児血液・がん学会, Oct. 2018
English

腸管気腫を来した血液腫瘍性疾患の2例
山本 俊亮, 西村 聡, 小野 林太郎, 山本 薫, 足洗 美穂, 平林 真介, 細谷 要介, 長谷川 大輔, 真部 淳
日本小児血液・がん学会雑誌, 55, 4, 335, 335, (一社)日本小児血液・がん学会, Oct. 2018
Japanese

AYA世代の小児がん経験者とそのきょうだいの心的外傷後ストレス症状(PTSS)と外傷体験後成長(PTG)
山本 薫, 永瀬 恭子, 郡司 美千代, 小林 京子, 平林 真介, 細谷 要介, 長谷川 大輔, 細谷 亮太, 石田 也寸志, 真部 淳, 小澤 美和
日本小児血液・がん学会雑誌, 55, 4, 343, 343, (一社)日本小児血液・がん学会, Oct. 2018
Japanese

小児がん経験者の知識とセルフマネジメントスキルの現状
小林 京子, 石田 也寸志, 郡司 美千代, 永瀬 恭子, 前田 邦枝, 小澤 美和, 細谷 要介, 長谷川 大輔, 細谷 亮太, 真部 淳
日本小児血液・がん学会雑誌, 55, 4, 382, 382, (一社)日本小児血液・がん学会, Oct. 2018
Japanese

集中治療室入院中の患児のきょうだいへの支援の一例
大久保 香織, 三浦 絵莉子, 野口 楓, 植松 温子, 長谷川 大輔, 小澤 美和, 真部 淳
日本小児血液・がん学会雑誌, 55, 4, 391, 391, (一社)日本小児血液・がん学会, Oct. 2018
Japanese

診断後10年で再発をきたしたTCF3-ZNF384陽性急性リンパ性白血病の1例(TCF3-ZNF384 positive acute lymphoblastic leukemia recurring 10 years after diagnosis)　　　　　　　　　　　　　　　
西村 聡, 平林 真介, 金淵 昭一郎, 山本 薫, 相賀 咲央莉, 細谷 要介, 大木 健太郎, 清河 信敬, 長谷川 大輔, 真部 淳
臨床血液, 59, 9, 1649, 1649, (一社)日本血液学会-東京事務局, Sep. 2018
English

急激な臨床経過を辿ったT細胞/骨髄性混合形質型急性白血病/リンパ腫(T/Myeloid mixed phenotype leukemia/lymphoma presenting aggressive clinical course)　　　　　　　　　　　　　　　
長谷川 大輔, 平林 真介, 宮本 智史, 木村 俊介, 吉本 優里, 細谷 要介, 吉田 健一, 小川 誠司, 真部 淳
臨床血液, 59, 9, 1650, 1650, (一社)日本血液学会-東京事務局, Sep. 2018
English

急性前骨髄球性白血病に生じた髄注後の亜急性白質脳症の一例(Subacute leukoencephalopathy after intrathecal methotrexate in a patient with APL)　　　　　　　　　　　　　　　
平林 真介, 西村 聡, 山本 薫, 山本 俊亮, 細谷 要介, 野崎 太希, 長谷川 大輔, 真部 淳
臨床血液, 59, 9, 1771, 1771, (一社)日本血液学会-東京事務局, Sep. 2018
English

Whole-exome analysis to detect congenital hemolytic anemia mimicking congenital dyserythropoietic anemia.
Motoharu Hamada, Sayoko Doisaki, Yusuke Okuno, Hideki Muramatsu, Asahito Hama, Nozomu Kawashima, Atsushi Narita, Nobuhiro Nishio, Kenichi Yoshida, Hitoshi Kanno, Atsushi Manabe, Takashi Taga, Yoshiyuki Takahashi, Satoru Miyano, Seishi Ogawa, Seiji Kojima
International journal of hematology, 108, 3, 306, 311, Sep. 2018, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Congenital dyserythropoietic anemia (CDA) is a heterogeneous group of rare congenital disorders characterized by ineffective erythropoiesis and dysplastic changes in erythroblasts. Diagnosis of CDA is based primarily on the morphology of bone marrow erythroblasts; however, genetic tests have recently become more important. Here, we performed genetic analysis of 10 Japanese patients who had been diagnosed with CDA based on laboratory findings and morphological characteristics. We examined 10 CDA patients via central review of bone marrow morphology and genetic analysis for congenital bone marrow failure syndromes. Sanger sequencing for CDAN1, SEC23B, and KLF1 was performed for all patients. We performed whole-exome sequencing in patients without mutation in these genes. Three patients carried pathogenic CDAN1 mutations, whereas no SEC23B mutations were identified in our cohort. WES unexpectedly identified gene mutations known to cause congenital hemolytic anemia in two patients: canonical G6PD p.Val394Leu mutation and SPTA1 p.Arg28His mutation. Comprehensive genetic analysis is warranted for more effective diagnosis of patients with suspected CDA.

Secondary bone/soft tissue sarcoma in childhood cancer survivors: a nationwide hospital-based case-series study in Japan.
Ishida Y, Maeda M, Adachi S, Rikiishi T, Sato M, Kawaguchi H, Manabe A, Tokuyama M, Hori H, Okamura J, Ogawa A, Goto H, Kobayashi R, Yoshinaga S, Fujimoto J, Kuroda T
Japanese journal of clinical oncology, 48, 9, 806, 814, Sep. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, Background: Secondary cancer is the most life-threatening late effect of childhood cancer. We investigated the clinical features of secondary bone/soft tissue sarcoma among childhood cancer survivors (CCSs). Methods: We conducted a retrospective case-series study of 10 069 CCSs newly diagnosed with cancer between 1980 and 2009 across 15 Japanese hospitals. Twenty-one cases of pathologically diagnosed secondary bone/soft tissue sarcoma were selected, and the respective clinical courses were determined using additional questionnaires. Results: The primary cancers included retinoblastoma (n = 7), acute lymphoblastic leukemia (n = 5), lymphoma (n = 5), osteosarcoma (n = 1), rhabdomyosarcoma (n = 1), brain tumor (n = 1) and Langerhans cell histiocytosis (n = 1). The median age at the primary cancer diagnosis was 2.9 years, and the male-to-female ratio was 16:5. The histological classifications of the secondary sarcoma included osteosarcoma (n = 10), malignant peripheral nerve sheath tumor (n = 4), rhabdomyosarcoma (n = 3), Ewing's sarcoma (n = 3) and primitive neuroectodermal tumor (n = 1). The median latency period to the secondary sarcoma was 10.2 years. Significant risk factors for secondary sarcoma in the multivariate Cox regression model included a history of retinoblastoma as the primary cancer (hazard ratio [HR], 20.9; 95% confidence interval [CI], 5.70-76.5) and autologous stem cell transplantation (SCT) (HR, 2.56; 95% CI, 1.08-6.03). Seventeen CCSs with secondary sarcoma underwent radiation, and nine, hematopoietic SCT. Twelve CCSs with secondary sarcoma achieved disease-free survival, while CCSs with hematological cancer or relapsed primary cancer who developed secondary sarcoma had the worst prognoses. Conclusion: The prognoses of CCSs with secondary sarcoma may depend on the primary cancer or prior relapse of primary cancer.

本邦におけるShwachman-Diamond症候群の全国的コホートの構築(Establishment of a nationwide cohort for Shwachman-Diamond syndrome in Japan)　　　　　　　　　　　　　　　
渡邉 健一郎, 金兼 弘和, 濱端 隆行, 上月 景弘, 梅田 雄嗣, 濱 麻人, 奥野 友介, 村松 秀城, 高橋 義行, 長谷川 大輔, 真部 淳, 小原 明, 伊藤 雅文, 小島 勢二, 伊藤 悦朗
臨床血液, 59, 9, 1497, 1497, (一社)日本血液学会-東京事務局, Sep. 2018, [Peer-reviewed]
English

Treatment outcome of children with acute lymphoblastic leukemia: the Tokyo Children’s Cancer Study Group (TCCSG) Study L04-16
Hiroyuki Takahashi, Ryosuke Kajiwara, Motohiro Kato, Daisuke Hasegawa, Daisuke Tomizawa, Yasushi Noguchi, Kazutoshi Koike, Daisuke Toyama, Hiromasa Yabe, Michiko Kajiwara, Junya Fujimura, Manabu Sotomatsu, Setsuo Ota, Miho Maeda, Hiroaki Goto, Yoko Kato, Tetsuya Mori, Takeshi Inukai, Hiroyuki Shimada, Keitaro Fukushima, Chitose Ogawa, Atsushi Makimoto, Takashi Fukushima, Kentaro Ohki, Katsuyoshi Koh, Nobutaka Kiyokawa, Atsushi Manabe, Akira Ohara
International Journal of Hematology, 108, 1, 98, 108, Springer Tokyo, 01 Jul. 2018, [Peer-reviewed]
English, Scientific journal

Phase II/III study in children and adolescents with newly diagnosed B-cell precursor acute lymphoblastic leukemia: protocol for a nationwide multicenter trial in Japan.
Koh K, Kato M, Saito AM, Kada A, Kawasaki H, Okamoto Y, Imamura T, Horibe K, Manabe A
Japanese journal of clinical oncology, 48, 7, 684, 691, Jul. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, B-cell precursor acute lymphoblastic leukemia is the most common pediatric malignancy, but its treatment needs to be modified to cause low acute toxicity and few late complications with a high cure rate. In this trial, we will stratify patients with B-cell precursor acute lymphoblastic leukemia into standard, intermediate and high risk groups according to prognostic factors. In addition, we will establish an evaluation system for minimal residual disease that will enable us to stratify patients based on minimal residual disease in subsequent clinical trials. We will clarify the impact of dexamethasone/vincristine pulse therapy during maintenance therapy in the standard risk group, and intensive l-asparaginase therapy in the intermediate risk group. In the high risk group, usefulness of vincristine intensification will be assessed. This trial has been registered in the UMIN Clinical Trials Registry as UMIN000009339 [http://www.umin.ac.jp/ctr/].

Nationwide survey of therapy-related leukemia in childhood in Japan
Toshihiko Imamura, Takashi Taga, Masatoshi Takagi, Hirohide Kawasaki, Katsuyoshi Koh, Tomohiko Taki, Souichi Adachi, Atsushi Manabe, Yasushi Ishida, On behalf of the Leukemia/Lymphoma Committee
International Journal of Hematology, 108, 1, 91, 97, Springer Tokyo, 01 Jul. 2018, [Peer-reviewed]
English, Scientific journal

Secondary cancer after a childhood cancer diagnosis: viewpoints considering primary cancer
Yasushi Ishida, Miho Maeda, Souichi Adachi, Hiroko Inada, Hiroshi Kawaguchi, Hiroki Hori, Atsushi Ogawa, Kazuko Kudo, Chikako Kiyotani, Hiroyuki Shichino, Takeshi Rikiishi, Ryoji Kobayashi, Maho Sato, Jun Okamura, Hiroaki Goto, Atsushi Manabe, Shinji Yoshinaga, Dongmei Qiu, Junichiro Fujimoto, Tatsuo Kuroda
International Journal of Clinical Oncology, 1, 11, Springer Tokyo, 05 Jun. 2018, [Peer-reviewed]
English, Scientific journal

MDS-predisposing syndromes モノソミー7を伴いclonal evolutionを来たしたPearson症候群の1例
山本 俊亮, 平林 真介, 山本 一希, 相賀 咲央莉, 西村 聡, 代田 惇朗, 細谷 要介, 藤原 亨, 張替 秀郎, 長谷川 大輔, 真部 淳
日本小児血液・がん学会雑誌, 55, 1, 67, 67, (一社)日本小児血液・がん学会, Jun. 2018
Japanese

MDS-predisposing syndromes MDS関連AMLを来たしたBloom症候群の1例
平林 真介, 長谷川 大輔, 山本 一希, 相賀 咲央莉, 西村 聡, 木村 俊介, 細谷 要介, 奥野 友介, 村松 秀城, 小島 勢二, 真部 淳
日本小児血液・がん学会雑誌, 55, 1, 68, 68, (一社)日本小児血液・がん学会, Jun. 2018
Japanese

Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy.
Rina Nishii, Takaya Moriyama, Laura J Janke, Wenjian Yang, Chase C Suiter, Ting-Nien Lin, Lie Li, Kentaro Kihira, Hidemi Toyoda, Ute Hofmann, Matthias Schwab, Masatoshi Takagi, Tomohiro Morio, Atsushi Manabe, Shirley Kham, Nan Jiang, Karen R Rabin, Motohiro Kato, Katsuyoshi Koh, Allen Eng-Juh Yeoh, Hiroki Hori, Jun J Yang
Blood, 131, 22, 2466, 2474, American Society of Hematology, 31 May 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal

腎生検にて確定診断に至った移植関連血栓性微小血管障害
宮本 智史, 木村 俊介, 細谷 要介, 長谷川 大輔, 石田 悠志, 代田 惇朗, 松井 俊大, 吉本 優里, 平林 真介, 藤丸 拓也, 熊本 忠史, 森 慎一郎, 鈴木 高祐, 真部 淳
臨床血液, 59, 4, 389, 394, (一社)日本血液学会-東京事務局, Apr. 2018
Japanese

Risk factors for psychological and psychosomatic symptoms among children with malignancies
Kenichi Maeda, Daisuke Hasegawa, Kevin Y Urayama, Shinichi Tsujimoto, Yuriko Azami, Miwa Ozawa, Atsushi Manabe
Journal of Paediatrics and Child Health, 54, 4, 411, 415, Blackwell Publishing, 01 Apr. 2018, [Peer-reviewed]
English, Scientific journal

NUDT15ハプロタイプの6-メルカプトプリン感受性への影響　　　　　　　　　　　　　　　
田中 庸一, 近藤 健介, 康 勝好, 尾鳥 勝也, 真部 淳
日本薬学会年会要旨集, 138年会, 4, 61, 61, (公社)日本薬学会, Mar. 2018
Japanese

Prognostic value of genetic mutations in adolescent and young adults with acute myeloid leukemia.
Yachiyo Kuwatsuka, Daisuke Tomizawa, Rika Kihara, Yasunobu Nagata, Norio Shiba, Yuka Iijima-Yamashita, Akira Shimada, Takao Deguchi, Hayato Miyachi, Akio Tawa, Takashi Taga, Akitoshi Kinoshita, Hideki Nakayama, Nobutaka Kiyokawa, Akiko Moriya Saito, Katsuyoshi Koh, Hiroaki Goto, Yoshiyuki Kosaka, Norio Asou, Shigeki Ohtake, Shuichi Miyawaki, Yasushi Miyazaki, Toru Sakura, Yukiyasu Ozawa, Noriko Usui, Heiwa Kanamori, Yoshikazu Ito, Kiyotoshi Imai, Youko Suehiro, Shinichi Kobayashi, Kunio Kitamura, Emiko Sakaida, Seishi Ogawa, Tomoki Naoe, Yasuhide Hayashi, Keizo Horibe, Atsushi Manabe, Shuki Mizutani, Souichi Adachi, Hitoshi Kiyoi
International journal of hematology, 107, 2, 201, 210, Feb. 2018, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Clinical outcomes and the genetic background of acute myeloid leukemia (AML) in adolescent and young adults (AYAs) are known to differ in younger children and older adults. To clarify the impact of genetic mutations on clinical outcomes of AYAs with AML, we analyzed data from the JPLSG AML-05 and JALSG AML201 studies. AYAs aged 15-39 years (n = 103) were included. FLT3-ITD, KIT, CEBPA, NRAS, KRAS, WT1, MLL-PTD, and NPM1 mutations were analyzed. Overall survival (OS) of the AYAs was 61% and event-free survival was 38% at 3 years. FLT3-ITD (HR 2.10; 95% CI 1.07-4.12; p = 0.031) and NPM1 (HR 0.24; 95% CI 0.06-1.00; p = 0.050) mutations were associated with risk of overall mortality in multivariate analysis. OS was significantly different according to FLT3-ITD and NPM1 mutation status (p = 0.03). Survival was 100% with NPM1 mutations in the absence of FLT3-ITD and 35% (95% CI 14-57%) with FLT3-ITD in the absence of NPM1 mutations. The OS of AYAs, children (n = 413) and older adults (n = 124) of the AML-05 and AML201 participants were significantly different (p < 0.0001). This is the first report to combine clinical and genetic data of AYA AML from the major Japanese pediatric and adult study groups.

幼弱T細胞性急性リンパ性白血病の予後因子の検討(Prognostic analysis of immature T-cell acute lymphoblastic leukemia)　　　　　　　　　　　　　　　
木村 俊介, 関 正史, 吉田 健一, 上野 浩生, 大木 健太郎, 小林 良二, 出口 隆生, 橋井 佳子, 今村 俊彦, 佐藤 篤, 清河 信敬, 小林 正夫, 岡 明, 林 泰秀, 真部 淳, 小原 明, 堀部 敬三, 宮野 悟, 小川 誠司, 滝田 順子
日本小児科学会雑誌, 122, 2, 234, 234, (公社)日本小児科学会, Feb. 2018, [Peer-reviewed]
English

小児がん経験者の成人男性の性機能及び性行動に関する検討　　　　　　　　　　　　　　　
相賀 咲央莉, 小澤 美和, 石田 也寸志, 長沖 優子, 伊藤 純子, 吉本 優里, 平林 真介, 細谷 要介, 長谷川 大輔, 真部 淳, 細谷 亮太
日本小児科学会雑誌, 122, 2, 358, 358, (公社)日本小児科学会, Feb. 2018
Japanese

[Transplantation-associated thrombotic microangiopathy confirmed by renal biopsy].
Miyamoto S, Kimura S, Hosoya Y, Hasegawa D, Ishida H, Daida A, Matsui T, Yoshimoto Y, Hirabayashi S, Fujimaru T, Kumamoto T, Mori SI, Suzuki K, Manabe A
[Rinsho ketsueki] The Japanese journal of clinical hematology, 59, 4, 389, 394, 2018, [Peer-reviewed]

Treatment and biology of pediatric acute lymphoblastic leukemia
Motohiro Kato, Atsushi Manabe
Pediatrics International, 60, 1, 4, 12, Blackwell Publishing, 01 Jan. 2018, [Peer-reviewed]
English

Survey of families regarding life of their children with cancer in wards
Irie Wataru, Hasegawa Daisuke, Kamiya Takahiro, Nagase Kyoko, Yoshikawa Kumiko, Sekitomi Akiko, Amano Kokoro, Ishii Rina, Serizawa Hiroko, Sakamoto Yokie, Ohno Naoko, Kanke Miwa, Tamura Taeko, Manabe Atsushi, Ishida Yasushi, Hirata Mika, Hosoya Ryota
The Japanese Journal of Pediatric Hematology / Oncology, 55, 1, 7, 14, The Japanese Society of Pediatric Hematology / Oncology, 2018
Japanese, Children with cancer require long-term hospitalization. Thus far, few studies have addressed issues related to the quality of life of childhood cancer patients during hospitalization from the children’s family perspective. In this study, we aimed to clarify the characteristics of childhood cancer patients’ lives in the hospital. Forty-three families of children with cancer who were hospitalized between April 2004 and October 2009 in our hospital participated in this cross-sectional questionnaire survey. Twenty-two families (51%) felt that the hospital regulations overly restrict TV viewing. This answer was not affected by children’s age and TV viewing time before hospitalization. The families who felt restricted by TV regulation answered that their children were under stress due to the deprivation of distraction. Hospitalized children were more likely to have a mobile phone than their age group peers who were not hospitalized. Over 50% of the families provided mobile phones to their children during hospitalization. Regarding hospital diet, 78% of families who experienced difficulty because they were prohibited from bringing their own meals from home and/or the store to their children felt that children did not eat hospital diet at all during hospitalization. Sixty-three percent of the families perceived a change in their children’s sense of taste. In particular, children tended to prefer salty and strong flavors during hospitalization. The results of our survey suggest that the utilization of electronic devices and bringing meals might lead to greater satisfaction during hospitalization rather than strictly adhering to hospital regulations. More flexibility in hospital regulations may improve the quality of life of hospitalized children with cancer.

Nationwide Survey of Pediatric Hypodiploid Acute Lymphoblastic Leukemia in Japan
Ishimaru Sae, Okamoto Yasuhiro, Imai Chihaya, Sakaguchi Hirotoshi, Taki Tomohiko, Hasegawa Daisuke, Cho Yuko, Kakuda Harumi, Sano Hideki, Manabe Atushi, Imamura Toshihiko, Kato Motohiro, Arakawa Yuki, Shimonodan Hidemi, Sato Atsushi, Suenobu So-ichi, Inukai Takeshi, Watanabe Arata, Kawano Yoshifumi, Kikuta Atsushi, Horibe Keizo, Ohara Akira, Koh Katsuyoshi
BLOOD, 130, 07 Dec. 2017, [Peer-reviewed]

A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study)
Takashi Kobayashi, Yasuhito Nannya, Motoshi Ichikawa, Kenji Oritani, Yuzuru Kanakura, Akihiro Tomita, Hitoshi Kiyoi, Masayoshi Kobune, Junji Kato, Hiroshi Kawabata, Motohiro Shindo, Yoshihiro Torimoto, Yuji Yonemura, Nobuyoshi Hanaoka, Hideki Nakakuma, Daisuke Hasegawa, Atsushi Manabe, Naohito Fujishima, Nobuharu Fujii, Mitsune Tanimoto, Yasuyoshi Morita, Akira Matsuda, Atsushi Fujieda, Naoyuki Katayama, Haruhiko Ohashi, Hirokazu Nagai, Yoshiki Terada, Masayuki Hino, Ken Sato, Naoshi Obara, Shigeru Chiba, Kensuke Usuki, Masatsugu Ohta, Osamu Imataki, Makiko Uemura, Tomoiku Takaku, Norio Komatsu, Akira Kitanaka, Kazuya Shimoda, Kenichiro Watanabe, Kaoru Tohyama, Akifumi Takaori-Kondo, Hideo Harigae, Shunya Arai, Yasushi Miyazaki, Keiya Ozawa, Mineo Kurokawa
AMERICAN JOURNAL OF HEMATOLOGY, 92, 12, 1324, 1332, Dec. 2017, [Peer-reviewed]
English, Scientific journal

Constitutional abnormalities of IDH1 combined with secondary mutations predispose a patient with Maffucci syndrome to acute lymphoblastic leukemia
Shinsuke Hirabayashi, Masafumi Seki, Daisuke Hasegawa, Motohiro Kato, Nobuyuki Hyakuna, Takuya Shuo, Shunsuke Kimura, Kenichi Yoshida, Keisuke Kataoka, Yoichi Fujii, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Nobutaka Kiyokawa, Satoru Miyano, Seishi Ogawa, Junko Takita, Atsushi Manabe
PEDIATRIC BLOOD & CANCER, 64, 12, Dec. 2017, [Peer-reviewed]
English, Scientific journal

複数の二次がんを来たした両側網膜芽細胞腫の若年成人例
平林 真介, 山本 俊亮, 山本 一希, 相賀 咲央莉, 西村 聡, 細谷 要介, 大曽根 眞也, 今村 俊彦, 熊本 忠史, 浜本 和子, 長谷川 大輔, 真部 淳
日本小児血液・がん学会雑誌, 54, 4, 378, 378, (一社)日本小児血液・がん学会, Oct. 2017
Japanese

AYA世代小児がん経験者の為の包括的ドックからの報告 食行動と生活習慣病への看護介入の必要性
前田 邦枝, 永瀬 恭子, 郡司 美千代, 小林 京子, 細谷 要介, 小澤 美和, 長谷川 大輔, 真部 淳, 石田 也寸志
日本小児血液・がん学会雑誌, 54, 4, 429, 429, (一社)日本小児血液・がん学会, Oct. 2017
Japanese

AYA世代小児がん経験者の長期フォローアップにおける自立支援ケア計画の視点と目標 実践報告
郡司 美千代, 永瀬 恭子, 小林 京子, 前田 邦枝, 小澤 美和, 細谷 要介, 長谷川 大輔, 真部 淳, 細谷 亮太, 石田 也寸志
日本小児血液・がん学会雑誌, 54, 4, 430, 430, (一社)日本小児血液・がん学会, Oct. 2017
Japanese

Plasma asparaginase activity, asparagine concentration, and toxicity after administration of Erwinia asparaginase in children and young adults with acute lymphoblastic leukemia: Phase I/II clinical trial in Japan
Chitose Ogawa, Fumi Taguchi, Hiroaki Goto, Katsuyoshi Koh, Daisuke Tomizawa, Akira Ohara, Atsushi Manabe
PEDIATRIC BLOOD & CANCER, 64, 9, Sep. 2017, [Peer-reviewed]
English, Scientific journal

Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia
Masafumi Seki, Shunsuke Kimura, Tomoya Isobe, Kenichi Yoshida, Hiroo Ueno, Yaeko Nakajima-Takagi, Changshan Wang, Lin Lin, Ayana Kon, Hiromichi Suzuki, Yusuke Shiozawa, Keisuke Kataoka, Yoichi Fujii, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Teppei Shimamura, Kyoko Masuda, Hiroshi Kawamoto, Kentaro Ohki, Motohiro Kato, Yuki Arakawa, Katsuyoshi Koh, Ryoji Hanada, Hiroshi Moritake, Masaharu Akiyama, Ryoji Kobayashi, Takao Deguchi, Yoshiko Hashii, Toshihiko Imamura, Atsushi Sato, Nobutaka Kiyokawa, Akira Oka, Yasuhide Hayashi, Masatoshi Takagi, Atsushi Manabe, Akira Ohara, Keizo Horibe, Masashi Sanada, Atsushi Iwama, Hiroyuki Mano, Satoru Miyano, Seishi Ogawa, Junko Takita
NATURE GENETICS, 49, 8, 1274, +, Aug. 2017, [Peer-reviewed]
English, Scientific journal

Bortezomib combined with standard induction chemotherapy in Japanese children with refractory acute lymphoblastic leukemia
Akihiro Iguchi, Yuko Cho, Minako Sugiyama, Yukayo Terashita, Tadashi Ariga, Yosuke Hosoya, Shinsuke Hirabayashi, Atsushi Manabe, Keisuke Hara, Tetsuya Aiba, Tsugumi Shiokawa, Hiroko Tada, Norihiro Sato
INTERNATIONAL JOURNAL OF HEMATOLOGY, 106, 2, 291, 298, Aug. 2017, [Peer-reviewed]
English, Scientific journal

EP300-ZNF384 fusion gene product up-regulates GATA3 gene expression and induces hematopoietic stem cell gene expression signature in B-cell precursor acute lymphoblastic leukemia cells
Akinori Yaguchi, Takeshi Ishibashi, Kazuki Terada, Hitomi Ueno-Yokohata, Yuya Saito, Junya Fujimura, Toshiaki Shimizu, Kentaro Ohki, Atsushi Manabe, Nobutaka Kiyokawa
INTERNATIONAL JOURNAL OF HEMATOLOGY, 106, 2, 269, 281, Aug. 2017, [Peer-reviewed]
English, Scientific journal

Salvage therapy for children with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia
Yuichi Kodama, Atsushi Manabe, Hirohide Kawasaki, Itaru Kato, Keisuke Kato, Atsushi Sato, Kimikazu Matsumoto, Motohiro Kato, Hidefumi Hiramatsu, Hideki Sano, Takashi Kaneko, Megumi Oda, Akiko M. Saito, Souichi Adachi, Keizo Horibe, Shuki Mizutani, Eiichi Ishii, Hiroyuki Shimada
PEDIATRIC BLOOD & CANCER, 64, 8, Aug. 2017, [Peer-reviewed]
English, Scientific journal

Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia
Masafumi Seki, Shunsuke Kimura, Tomoya Isobe, Kenichi Yoshida, Hiroo Ueno, Yaeko Nakajima-Takagi, Changshan Wang, Lin Lin, Ayana Kon, Hiromichi Suzuki, Yusuke Shiozawa, Keisuke Kataoka, Yoichi Fujii, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Teppei Shimamura, Kyoko Masuda, Hiroshi Kawamoto, Kentaro Ohki, Motohiro Kato, Yuki Arakawa, Katsuyoshi Koh, Ryoji Hanada, Hiroshi Moritake, Masaharu Akiyama, Ryoji Kobayashi, Takao Deguchi, Yoshiko Hashii, Toshihiko Imamura, Atsushi Sato, Nobutaka Kiyokawa, Akira Oka, Yasuhide Hayashi, Masatoshi Takagi, Atsushi Manabe, Akira Ohara, Keizo Horibe, Masashi Sanada, Atsushi Iwama, Hiroyuki Mano, Satoru Miyano, Seishi Ogawa, Junko Takita
Nature Genetics, 49, 8, 1274, 1281, Nature Publishing Group, 01 Aug. 2017, [Peer-reviewed]
English, Scientific journal

Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes
Hideki Muramatsu, Yusuke Okuno, Kenichi Yoshida, Yuichi Shiraishi, Sayoko Doisaki, Atsushi Narita, Hirotoshi Sakaguchi, Nozomu Kawashima, Xinan Wang, Yinyan Xu, Kenichi Chiba, Hiroko Tanaka, Asahito Hama, Masashi Sanada, Yoshiyuki Takahashi, Hitoshi Kanno, Hiroki Yamaguchi, Shouichi Ohga, Atsushi Manabe, Hideo Harigae, Shinji Kunishima, Eiichi Ishii, Masao Kobayashi, Kenichi Koike, Kenichiro Watanabe, Etsuro Ito, Minoru Takata, Miharu Yabe, Seishi Ogawa, Satoru Miyano, Seiji Kojima
GENETICS IN MEDICINE, 19, 7, 796, 802, Jul. 2017, [Peer-reviewed]
English, Scientific journal

Myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML)
Daisuke Hasegawa, Atsushi Manabe
Hematological Disorders in Children: Pathogenesis and Treatment, 87, 108, Springer Singapore, 14 Jun. 2017, [Peer-reviewed]
English, In book

C型肝炎ウイルス持続感染を伴う再発急性骨髄性白血病の小児に対する化学療法の経験
木村 俊介, 平林 真介, 長谷川 大輔, 角谷 和歌子, 瀬谷 恵, 松井 俊大, 吉本 優里, 細谷 要介, 森 信好, 松井 陽, 真部 淳
臨床血液, 58, 6, 619, 623, (一社)日本血液学会-東京事務局, Jun. 2017
Japanese

The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia
Takaya Moriyama, Rina Nishii, Ting-Nien Lin, Kentaro Kihira, Hidemi Toyoda, Nersting Jacob, Motohiro Kato, Katsuyoshi Koh, Hiroto Inaba, Atsushi Manabe, Kjeld Schmiegelow, Jun J. Yang, Hiroki Hori
PHARMACOGENETICS AND GENOMICS, 27, 6, 236, 239, Jun. 2017, [Peer-reviewed]
English, Scientific journal

ZNF384関連融合遺伝子はALLの細胞マーカーに特徴を有する亜群を規定する　　　　　　　　　　　　　　　
清河 信敬, 大木 健太郎, 平林 真介, 福島 敬, 康 勝好, 真部 淳, 小原 明
Cytometry Research, 27, Suppl., 64, 64, (一社)日本サイトメトリー学会, Jun. 2017
Japanese

Risk Factors for Hospital-acquired Clostridium difficile Infection Among Pediatric Patients With Cancer
Atsuro Daida, Hiroki Yoshihara, Ikuko Inai, Daisuke Hasegawa, Yasushi Ishida, Kevin Y. Urayama, Atsushi Manabe
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 39, 3, E167, E172, Apr. 2017, [Peer-reviewed]
English, Scientific journal

Interaction between NUDT15 and ABCC4 variants enhances intolerability of 6-mercaptopurine in Japanese patients with childhood acute lymphoblastic leukemia.
Tanaka Y, Nakadate H, Kondoh K, Nakamura K, Koh K, Manabe A
The pharmacogenomics journal, Apr. 2017, [Peer-reviewed]

Infantile fibrosarcoma treated with postoperative vincristine and dactinomycin
Hiroki Yoshihara, Yuri Yoshimoto, Yosuke Hosoya, Daisuke Hasegawa, Takafumi Kawano, Akiko Sakoda, Hajime Okita, Atsushi Manabe
PEDIATRICS INTERNATIONAL, 59, 3, 371, 374, Mar. 2017, [Peer-reviewed]
English, Scientific journal

Pediatric intestinal Beh double dagger et disease complicated by myeloid malignancies
Kiichiro Kanamitsu, Akira Shimada, Ritsuo Nishiuchi, Tomonari Shigemura, Yozo Nakazawa, Kenichi Koike, Yuichi Kodama, Yuichi Shinkoda, Yoshifumi Kawano, Kozo Yasui, Koji Sasaki, Ryosuke Kajiwara, Hirokazu Tsukahara, Atsushi Manabe
INTERNATIONAL JOURNAL OF HEMATOLOGY, 105, 3, 377, 382, Mar. 2017, [Peer-reviewed]
English, Scientific journal

小児急性リンパ性白血病患児における高用量メトトレキサート投与後の血中濃度に影響を与える因子の検討　　　　　　　　　　　　　　　
田中 庸一, 浦山 ケビン, 森 麻希子, 長谷川 大輔, 太田 節雄, 柳町 昌克, 康 勝好, 尾鳥 勝也, 真部 淳
日本薬学会年会要旨集, 137年会, 4, 176, 176, (公社)日本薬学会, Mar. 2017, [Peer-reviewed]
Japanese

Long-term outcome of 6-month maintenance chemotherapy for acute lymphoblastic leukemia in children.
M Kato, S Ishimaru, M Seki, K Yoshida, Y Shiraishi, K Chiba, N Kakiuchi, Y Sato, H Ueno, H Tanaka, T Inukai, D Tomizawa, D Hasegawa, T Osumi, Y Arakawa, T Aoki, M Okuya, K Kaizu, K Kato, Y Taneyama, H Goto, T Taki, M Takagi, M Sanada, K Koh, J Takita, S Miyano, S Ogawa, A Ohara, M Tsuchida, A Manabe
Leukemia, 31, 3, 580, 584, Mar. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, In the treatment of childhood acute lymphoblastic leukemia (ALL), excess shortening of maintenance therapy resulted in high relapse rate, as shown by our previous trial, TCCSG L92-13, in which maintenance therapy was terminated at 1 year from initiation of treatment. In this study, we aimed to confirm the long-term outcome of L92-13, and to identify who can or cannot be cured by shorter duration of maintenance therapy. To obtain sentinel cytogenetics information that had been missed before, we performed genetic analysis with genomic microarray and target intron-capture sequencing from diagnostic bone marrow smear. Disease-free survival (DFS) at 10 years from the end of therapy was 66.0±2.8%. Females (n=138) had better DFS (74.6±3.7%) than males (n=142, 57.5±4.2%, P=0.002). Patients with TCF3-PBX1 (n=11) and ETV6-RUNX1 (n=16) had excellent DFS (90.9±8.7% and 93.8±6.1%, respectively), whereas high hyperdiploidy (n=23) was the most unfavorable subgroup, with 56.6±10.3% of DFS. Short duration of therapy can cure more than half of pediatric ALL, especially females, TCF3-PBX1 and ETV6-RUNX1. Our retrospective observations suggest a gender/karyotype inhomogeneity on the impact of brief therapy.

Long-term outcome of 6-month maintenance chemotherapy for acute lymphoblastic leukemia in children
M. Kato, S. Ishimaru, M. Seki, K. Yoshida, Y. Shiraishi, K. Chiba, N. Kakiuchi, Y. Sato, H. Ueno, H. Tanaka, T. Inukai, D. Tomizawa, D. Hasegawa, T. Osumi, Y. Arakawa, T. Aoki, M. Okuya, K. Kaizu, K. Kato, Y. Taneyama, H. Goto, T. Taki, M. Takagi, M. Sanada, K. Koh, J. Takita, S. Miyano, S. Ogawa, A. Ohara, M. Tsuchida, A. Manabe
LEUKEMIA, 31, 3, 580, 584, Mar. 2017, [Peer-reviewed]
English, Scientific journal

乳児急性リンパ性白血病に対する化学療法後に重症の複合免疫不全状態を呈した女児　　　　　　　　　　　　　　　
長谷川 大輔, 吉本 優里, 木村 俊介, 平林 真介, 吉原 宏樹, 細谷 要介, 宮本 智史, 小倉 友美, 今井 耕輔, 真部 淳
日本小児科学会雑誌, 121, 2, 465, 465, (公社)日本小児科学会, Feb. 2017
Japanese

Haploidentical hematopoietic cell transplantation for disseminated Ewing sarcoma
Hiroki Yoshihara, Tadashi Kumamoto, Rintaro Ono, Keiko Akahane, Taiki Nozaki, Shogo Kobayashi, Atsushi Kikuta, Seiichi Matsumoto, Daisuke Hasegawa, Chitose Ogawa, Atsushi Manabe
PEDIATRICS INTERNATIONAL, 59, 2, 223, 226, Feb. 2017, [Peer-reviewed]
English, Scientific journal

小児白血病における血液凝固障害に対する支持療法 JPLSGアンケート調査　　　　　　　　　　　　　　　
大曽根 眞也, 福島 啓太郎, 矢野 道広, 嘉数 真理子, 佐野 弘純, 加藤 陽子, 新小田 雄一, 篠田 邦大, 真部 淳, 足立 壮一
日本小児科学会雑誌, 121, 2, 251, 251, (公社)日本小児科学会, Feb. 2017
Japanese

小児白血病診療時の中心静脈カテーテルの使用・管理法 JPLSGアンケート調査　　　　　　　　　　　　　　　
佐野 弘純, 福島 啓太郎, 矢野 道広, 大曽根 眞也, 嘉数 真理子, 加藤 陽子, 新小田 雄一, 篠田 邦大, 真部 淳, 足立 壮一, 日本小児白血病リンパ腫研究グループ
日本小児科学会雑誌, 121, 2, 467, 467, (公社)日本小児科学会, Feb. 2017
Japanese

小児白血病における抗腫瘍薬の急性毒性に対する対策の現状 JPLSGアンケート調査　　　　　　　　　　　　　　　
矢野 道広, 福島 啓太郎, 佐野 弘純, 大曽根 眞也, 嘉数 真理子, 加藤 陽子, 新小田 雄一, 篠田 邦大, 真部 淳, 足立 壮一, 日本小児白血病リンパ腫研究グループ
日本小児科学会雑誌, 121, 2, 467, 467, (公社)日本小児科学会, Feb. 2017
Japanese

Familial hematological malignancies.
Shinsuke Hirabayashi, Atsushi Manabe
[Rinsho ketsueki] The Japanese journal of clinical hematology, 58, 10, 1878, 1883, 2017, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues was last updated in 2008. The study of cancer genomes has identified inherited genetic drivers that predispose cancer cells to clonal evolution. The revisions in the categories of myeloid neoplasms and acute leukemia were published as a monograph in 2016. We described familial hematological malignancies using the 2016 edition of the WHO classification.

Phase I study of glypican-3-derived peptide vaccine therapy for patients with refractory pediatric solid tumors.
Tsuchiya N, Hosono A, Yoshikawa T, Shoda K, Nosaka K, Shimomura M, Hara J, Nitani C, Manabe A, Yoshihara H, Hosoya Y, Kaneda H, Kinoshita Y, Kohashi K, Yoshimura K, Fujinami N, Saito K, Mizuno S, Nakatsura T
Oncoimmunology, 7, 1, e1377872, 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, The carcinoembryonic antigen glypican-3 (GPC3) is a good target of anticancer immunotherapy against pediatric solid tumors expressing GPC3. In this non-randomized, open-label, phase I clinical trial, we analyzed the safety and efficacy of GPC3-peptide vaccination in patients with pediatric solid tumors. Eighteen patients with pediatric solid tumors expressing GPC3 underwent GPC3-peptide vaccination (intradermal injections every 2 weeks), with the primary endpoint being the safety of GPC3-peptide vaccination and the secondary endpoints being immune response, as measured by interferon (IFN)-γ enzyme-linked immunospot assay and Dextramer staining, and the clinical outcomes of tumor response, progression free survival (PFS), and overall survival (OS). Our findings indicated that GPC3 vaccination was well tolerated. We observed disease-control rates [complete response (CR)+partial response+stable disease] of 66.7% after 2 months, and although patients in the progression group unable to induce GPC3-peptide-specific cytotoxic T lymphocytes (CTLs) received poor prognoses, patients in the partial-remission and remission groups or those with hepatoblastoma received good prognoses. The GPC3-peptide vaccine induced a GPC3-specific CTL response in seven patients, with PFS and OS significantly longer in patients with high GPC3-specific CTL frequencies than in those with low frequencies. Furthermore, we established GPC3-peptide-specific CTL clones from a resected-recurrent tumor from one patient, with these cells exhibiting GPC3-peptide-specific cytokine secretion. The results of this trial demonstrated that the GPC3-peptide-specific CTLs induced by the GPC3-peptide vaccine infiltrated tumor tissue, and use of the GPC3-peptide vaccine might prevent the recurrence of pediatric solid tumors, especially hepatoblastomas, after a second CR.

ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype
Shinsuke Hirabayashi, Kentaro Ohki, Kazuhiko Nakabayashi, Hitoshi Ichikawa, Yukihide Momozawa, Kohji Okamura, Akinori Yaguchi, Kazuki Terada, Yuya Saito, Ai Yoshimi, Hiroko Ogata-Kawata, Hiromi Sakamoto, Motohiro Kato, Junya Fujimura, Moeko Hino, Akitoshi Kinoshita, Harumi Kakuda, Hidemitsu Kurosawa, Keisuke Kato, Ryosuke Kajiwara, Koichi Moriwaki, Tsuyoshi Morimoto, Kozue Nakamura, Yasushi Noguchi, Tomoo Osumi, Kazuo Sakashita, Junko Takita, Yuki Yuza, Koich Matsuda, Teruhiko Yoshida, Kenji Matsumoto, Kenichiro Hata, Michiaki Kubo, Yoichi Matsubara, Takashi Fukushima, Katsuyoshi Koh, Atsushi Manabe, Akira Ohara, Nobutaka Kiyokawa
HAEMATOLOGICA, 102, 1, 118, 129, Jan. 2017, [Peer-reviewed]
English, Scientific journal

ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype.
Shinsuke Hirabayashi, Kentaro Ohki, Kazuhiko Nakabayashi, Hitoshi Ichikawa, Yukihide Momozawa, Kohji Okamura, Akinori Yaguchi, Kazuki Terada, Yuya Saito, Ai Yoshimi, Hiroko Ogata-Kawata, Hiromi Sakamoto, Motohiro Kato, Junya Fujimura, Moeko Hino, Akitoshi Kinoshita, Harumi Kakuda, Hidemitsu Kurosawa, Keisuke Kato, Ryosuke Kajiwara, Koichi Moriwaki, Tsuyoshi Morimoto, Kozue Nakamura, Yasushi Noguchi, Tomoo Osumi, Kazuo Sakashita, Junko Takita, Yuki Yuza, Koich Matsuda, Teruhiko Yoshida, Kenji Matsumoto, Kenichiro Hata, Michiaki Kubo, Yoichi Matsubara, Takashi Fukushima, Katsuyoshi Koh, Atsushi Manabe, Akira Ohara, Nobutaka Kiyokawa
Haematologica, 102, 1, 118, 129, Jan. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, Fusion genes involving ZNF384 have recently been identified in B-cell precursor acute lymphoblastic leukemia, and 7 fusion partners have been reported. We further characterized this type of fusion gene by whole transcriptome sequencing and/or polymerase chain reaction. In addition to previously reported genes, we identified BMP2K as a novel fusion partner for ZNF384 Including the EP300-ZNF384 that we reported recently, the total frequency of ZNF384-related fusion genes was 4.1% in 291 B-cell precursor acute lymphoblastic leukemia patients enrolled in a single clinical trial, and TCF3-ZNF384 was the most recurrent, with a frequency of 2.4%. The characteristic immunophenotype of weak CD10 and aberrant CD13 and/or CD33 expression was revealed to be a common feature of the leukemic cells harboring ZNF384-related fusion genes. The signature gene expression profile in TCF3-ZNF384-positive patients was enriched in hematopoietic stem cell features and related to that of EP300-ZNF384-positive patients, but was significantly distinct from that of TCF3-PBX1-positive and ZNF384-fusion-negative patients. However, clinical features of TCF3-ZNF384-positive patients are markedly different from those of EP300-ZNF384-positive patients, exhibiting higher cell counts and a younger age at presentation. TCF3-ZNF384-positive patients revealed a significantly poorer steroid response and a higher frequency of relapse, and the additional activating mutations in RAS signaling pathway genes were detected by whole exome analysis in some of the cases. Our observations indicate that ZNF384-related fusion genes consist of a distinct subgroup of B-cell precursor acute lymphoblastic leukemia with a characteristic immunophenotype, while the clinical features depend on the functional properties of individual fusion partners.

Pediatric thromboembolism: a national survey in Japan
Akira Ishiguro, Chibueze Chioma Ezinne, Nobuaki Michihata, Hisaya Nakadate, Atsushi Manabe, Masashi Taki, Midori Shima
INTERNATIONAL JOURNAL OF HEMATOLOGY, 105, 1, 52, 58, Jan. 2017, [Peer-reviewed]
English, Scientific journal

Chemotherapy for a child with relapsed acute myeloid leukemia complicated with persistent hepatitis C virus infection.
Shunsuke Kimura, Shinsuke Hirabayashi, Daisuke Hasegawa, Wakako Sumiya, Megumi Seya, Toshihiro Matsui, Yuri Yoshimoto, Yosuke Hosoya, Nobuyoshi Mori, Akira Matsui, Atsushi Manabe
[Rinsho ketsueki] The Japanese journal of clinical hematology, 58, 6, 619, 623, 2017, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, An 8-year-old Mongolian female was diagnosed with acute myeloid leukemia (AML) and treated at a hospital in Mongolia according to the BFM-AML2004 SR protocol. Although complete remission (CR) was achieved, chemotherapy was interrupted because of shortage of drugs. The patient moved to Japan 7 months after diagnosis. Screening for viral infection revealed the presence of hepatitis C virus (HCV) antibody and RNA. At 11 months after initial diagnosis, the patient experienced bone marrow relapse and a RUNX1-RUNX1T1 fusion transcript was detected. Considering the inadequate intensity of initial treatment and the persistent HCV infection, chemotherapy was preferred and initiated over hematopoietic cell transplantation. After the first course of induction therapy, a second CR was confirmed and the chimeric transcript disappeared. The viral load mildly increased during myelosuppression and transient elevation of liver enzymes was observed along with hematological recovery. HCV infection remained stable, without progression to reactivation of hepatitis C. Given the high risk of second relapse and liver fibrosis and sclerosis following chronic HCV infection, treatment against HCV may be indicated during second remission.

Pediatric thromboembolism: a national survey in Japan
Akira Ishiguro, Chibueze Chioma Ezinne, Nobuaki Michihata, Hisaya Nakadate, Atsushi Manabe, Masashi Taki, Midori Shima
International Journal of Hematology, 105, 1, 52, 58, Springer Tokyo, 01 Jan. 2017, [Peer-reviewed]
English, Scientific journal

The Association Between L-Asparaginase Hypersensitivity and Genetic Variants in Japanese Childhood ALL Patients
Yoichi Tanaka, Kevin Y. Urayama, Takahisa Kawaguchi, Makiko Mori, Daisuke Hasegawa, Sae Ishimaru, Yuichi Taneyama, Kazuki Terada, Masakatsu Yanagimachi, Setsuo Ota, Hiroyuki Takahashi, Takeshi Inukai, Daisuke Toyama, Dai Keino, Koichi Moriwaki, Masatoshi Takagi, Junya Fujimura, Yujin Sekinaka, Kozue Nakamura, Yuya Sato, Keitaro Matsuo, Akira Ohara, Katsuyoshi Koh, Fumihiko Matsuda, Atsushi Manabe
BLOOD, 128, 22, Dec. 2016, [Peer-reviewed]
English

劇症型G群溶血性連鎖球菌感染症に罹患した治療不応フィラデルフィア染色体陽性急性リンパ性白血病の一小児例(Invasive group G streptococcal infection in a child with refractory Philadelphia chromosome-positive acute lymphoblastic leukemia)
松井 俊大, 長谷川 大輔, 吉本 優里, 梅原 直, 平林 真介, 細谷 要介, 稲井 郁子, 熊本 忠史, 真部 淳
日本小児血液・がん学会雑誌, 53, 4, 338, 338, (一社)日本小児血液・がん学会, Nov. 2016
English

小児血液・がん疾患に対する治療中に可逆性後頭部白質脳症症候群(PRES)をきたした3例(Posterior reversible encephalopathy syndrome(PRES) in pediatric cancer patients)
代田 惇朗, 長谷川 大輔, 山本 一希, 瀬谷 恵, 木村 俊介, 吉本 優里, 平林 真介, 細谷 要介, 野崎 大希, 横山 美奈, 荻原 正明, 真部 淳
日本小児血液・がん学会雑誌, 53, 4, 368, 368, (一社)日本小児血液・がん学会, Nov. 2016
English

再発神経芽腫において獲得された片親性ダイソミーによるALK遺伝子のホモ変異(Homozygous missense mutation in ALK gene due to acquired uniparental disomy in a child with relapsed neuroblastoma)
木村 俊介, 長谷川 大輔, 代田 惇朗, 関 正史, 吉本 優里, 平林 真介, 細谷 要介, 滝田 順子, 真部 淳
日本小児血液・がん学会雑誌, 53, 4, 238, 238, (一社)日本小児血液・がん学会, Nov. 2016
English

MEF2DおよびZNF384関連融合遺伝子陽性症例は小児B前駆細胞性ALLの中のサブグループを形成する(Incidence and clinical relevance of MEF2D- and ZNF384-related fusion genes in childhood B-cell precursor acute lymphoblastic leukemia: TCCSG L0416/0616 study)
大木 健太郎, 平林 真介, 加藤 元博, 中林 一彦, 秦 健一郎, 梶原 良介, 高橋 浩之, 福島 敬, 康 勝好, 真部 淳, 小原 明, 清河 信敬
日本小児血液・がん学会雑誌, 53, 4, 259, 259, (一社)日本小児血液・がん学会, Nov. 2016
English

小児再発急性リンパ性白血病患者に対するボルテゾミブ併用多剤化学療法の安全性を検討する第I相試験(Phase I Study of Bortezomib-Containing Multiagent Chemotherapy in Children with Relapsed Acute Lymphoblastic Leukemia)
長谷川 大輔, 熊本 忠史, 齋藤 明子, 嘉田 晃子, 山下 友加, 前田 尚子, 菊田 敦, 原 純一, 真部 淳, 小川 千登世
日本小児血液・がん学会雑誌, 53, 4, 253, 253, (一社)日本小児血液・がん学会, Nov. 2016
English

本邦における小児がん患児に対する疼痛管理の現状と課題 JPLSG施設調査より
加藤 陽子, 福島 啓太郎, 新小田 雄一, 森 尚子, 大曽根 眞也, 嘉数 真理子, 佐野 弘純, 篠田 邦大, 矢野 道広, 真部 淳, 足立 壯一, 日本小児白血病リンパ腫研究グループ(JPLSG)
日本小児血液・がん学会雑誌, 53, 4, 271, 271, (一社)日本小児血液・がん学会, Nov. 2016
Japanese

本邦における小児緩和ケア提供体制の現状と課題 JPLSG施設調査より
森 尚子, 福島 啓太郎, 加藤 陽子, 新小田 雄一, 大曽根 眞也, 嘉数 真理子, 佐野 弘純, 篠田 邦大, 矢野 道広, 真部 淳, 足立 壯一, 日本小児白血病リンパ腫研究グループ(JPLSG)
日本小児血液・がん学会雑誌, 53, 4, 271, 271, (一社)日本小児血液・がん学会, Nov. 2016
Japanese

本邦における小児がん患者に対する検査・処置時の鎮静および疼痛管理の現状と課題 JPLSG施設調査より
新小田 雄一, 福島 啓太郎, 加藤 陽子, 森 尚子, 大曽根 眞也, 嘉数 真理子, 佐野 弘純, 篠田 邦大, 矢野 道広, 真部 淳, 足立 壮一, 日本小児白血病リンパ腫研究グループ(JPLSG)
日本小児血液・がん学会雑誌, 53, 4, 355, 355, (一社)日本小児血液・がん学会, Nov. 2016
Japanese

小児白血病における腫瘍崩壊症候群およびhyperleukocytosisに対する対応 JPLSG施設アンケート調査の結果
嘉数 真理子, 福島 啓太郎, 矢野 道広, 大曽根 眞也, 佐野 弘純, 加藤 陽子, 新小田 雄一, 篠田 邦大, 真部 淳, 足立 壯一, 日本小児白血病リンパ腫研究グループ(JPLSG)
日本小児血液・がん学会雑誌, 53, 4, 369, 369, (一社)日本小児血液・がん学会, Nov. 2016
Japanese

下肢痛にて発症した壊血病の1例　　　　　　　　　　　　　　　
瀬谷 恵, 半田 淳比古, 松井 俊大, 吉本 優里, 長谷川 大輔, 小澤 美和, 真部 淳, 草川 功
日本小児科学会雑誌, 120, 11, 1695, 1695, (公社)日本小児科学会, Nov. 2016
Japanese

当院における小児がんの晩期合併症に関する検討(Late effects in the children of cancer survivors: from the single institute experience)
齋藤 合, 吉本 優里, 細谷 要介, 平林 真介, 長谷川 大輔, 石田 也寸志, 浦山 ケビン, 小澤 美和, 細谷 亮太, 真部 淳
日本小児血液・がん学会雑誌, 53, 4, 275, 275, (一社)日本小児血液・がん学会, Nov. 2016
English

軽症血友病Aに合併した慢性特発性血小板減少症性紫斑病に対して脾臓摘出術を行った1例
瀬谷 恵, 長谷川 大輔, 平林 真介, 細谷 要介, 小澤 美和, 迫田 晃子, 松藤 凡, 真部 淳
日本小児血液・がん学会雑誌, 53, 4, 321, 321, (一社)日本小児血液・がん学会, Nov. 2016
Japanese

高リスク神経芽腫発症から23年後に膀胱癌を発症した一例
細谷 要介, 長谷川 大輔, 永瀬 恭子, 郡司 美千代, 小林 京子, 小澤 美和, 石田 也寸志, 鈴木 高祐, 服部 一紀, 真部 淳
日本小児血液・がん学会雑誌, 53, 4, 397, 397, (一社)日本小児血液・がん学会, Nov. 2016
Japanese

母子共に末期がんの家族に対するチームアプローチにおける多職種カンファレンスの意義
小口 祐子, 大川 智子, 小川 恵理子, 阿佐美 百合子, 宮本 智史, 木村 俊介, 長谷川 大輔, 小澤 美和, 真部 淳, 山本 光映
日本小児血液・がん学会雑誌, 53, 4, 444, 444, (一社)日本小児血液・がん学会, Nov. 2016
Japanese

小児造血器腫瘍に対する共通免疫学的診断パネルによって診断されたBilineal Leukemiaの特徴(The characteristics of Bilineal Leukemia diagnosed by nationwide immunophenotyping for pediatric hematological malignancy in Japan)
出口 隆生, 清河 信敬, 大木 健太郎, 橋井 佳子, 真部 淳, 足立 壯一, 齋藤 明子, 堀部 敬三, 駒田 美弘
日本小児血液・がん学会雑誌, 53, 4, 280, 280, (一社)日本小児血液・がん学会, Nov. 2016
English

本邦において2002年から2011年までに発生した2例の小児BCL2およびMYC dual-hit白血病(Two cases of pediatric BCL2 and MYC dual-hit leukemia between 2002 and 2011 in Japan)
坂口 公祥, 今村 俊彦, 石丸 紗恵, 今井 千速, 下之段 秀美, 岡田 恵子, 出口 隆生, 橋井 佳子, 清河 信敬, 齋藤 明子, 真部 淳, 佐藤 篤, 康 勝好
日本小児血液・がん学会雑誌, 53, 4, 370, 370, (一社)日本小児血液・がん学会, Nov. 2016
English

小児再生不良性貧血および骨髄異形成症候群の形態中央診断 1500例のまとめ(Central morphology review of aplastic anemia and myelodysplastic syndrome in children: the summary of 1,500 cases)
濱 麻人, 真部 淳, 長谷川 大輔, 野沢 和江, 成田 敦, 村松 秀城, 高橋 義行, 渡邉 健一郎, 小原 明, 伊藤 雅文, 小島 勢二
日本小児血液・がん学会雑誌, 53, 4, 233, 233, (一社)日本小児血液・がん学会, Nov. 2016, [Peer-reviewed]
English

本邦における治療関連性急性白血病および悪性リンパ腫の全国調査結果について(Nation-wide survey of therapy related leukemia and lymphoma in Japan)
今村 俊彦, 多賀 崇, 高木 正稔, 河崎 裕英, 康 勝好, 滝 智彦, 足立 壮一, 真部 淳, 石田 也寸志, 日本小児血液・がん学会白血病リンパ腫委員会
日本小児血液・がん学会雑誌, 53, 4, 275, 275, (一社)日本小児血液・がん学会, Nov. 2016, [Peer-reviewed]
English

Cervical ultrasound and computed tomography of Kawasaki disease: Comparison with lymphadenitis
Taiki Nozaki, Yuka Morita, Daisuke Hasegawa, Akari Makidono, Yuri Yoshimoto, Jay Starkey, Isao Kusakawa, Atsushi Manabe, Yukihisa Saida
PEDIATRICS INTERNATIONAL, 58, 11, 1146, 1152, Nov. 2016, [Peer-reviewed]
English, Scientific journal

Cervical ultrasound and computed tomography of Kawasaki disease: Comparison with lymphadenitis
Taiki Nozaki, Yuka Morita, Daisuke Hasegawa, Akari Makidono, Yuri Yoshimoto, Jay Starkey, Isao Kusakawa, Atsushi Manabe, Yukihisa Saida
Pediatrics International, 58, 11, 1146, 1152, Blackwell Publishing, 01 Nov. 2016, [Peer-reviewed]
English, Scientific journal

本邦におけるt(8;14)(q24;q32)再構成を伴う小児の前駆B細胞性急性リンパ芽球性白血病(Pediatric B cell precursor acute lymphoblastic leukemia with t(8;14)(q24;q32) rearrangement in Japan)　　　　　　　　　　　　　　　
Sakaguchi Kimiyoshi, Imamura Toshihiko, Ishimaru Sae, Imai Chihaya, Shimonodan Hidemi, Hamamoto Kazuko, Okada Keiko, Taketani Takeshi, Kanai Rie, Kato Motohiro, Kojima Yasuko, Watanabe Arata, Deguchi Takao, Hashii Yoshiko, Kiyokawa Nobutaka, Saito-Moriya Akiko, Manabe Atsushi, Sato Atsushi, Koh Katsuyoshi
臨床血液, 57, 9, 1503, 1503, (一社)日本血液学会-東京事務局, Sep. 2016
English

脳動静脈奇形(AVM)の出血に対し血管内塞栓術とAVM摘出術を施行した2ヵ月女児例　　　　　　　　　　　　　　　
後藤 耕策, 吉本 優里, 角谷 和歌子, 松井 俊大, 秋山 類, 藤井 本晴, 小澤 美和, 真部 淳, 新見 康成, 草川 功
日本小児科学会雑誌, 120, 9, 1393, 1393, (公社)日本小児科学会, Sep. 2016
Japanese

Ewing sarcoma/primitive neuroectodermal tumor of the kidney treated with chemotherapy including ifosfamide
Hiroki Yoshihara, Takahiro Kamiya, Yosuke Hosoya, Daisuke Hasegawa, Chitose Ogawa, Hiroshi Asanuma, Ryuichi Mizuno, Ryota Hosoya, Atsushi Manabe
PEDIATRICS INTERNATIONAL, 58, 8, 766, 769, Aug. 2016, [Peer-reviewed]
English, Scientific journal

Ewing sarcoma/primitive neuroectodermal tumor of the kidney treated with chemotherapy including ifosfamide
Hiroki Yoshihara, Takahiro Kamiya, Yosuke Hosoya, Daisuke Hasegawa, Chitose Ogawa, Hiroshi Asanuma, Ryuichi Mizuno, Ryota Hosoya, Atsushi Manabe
Pediatrics International, 58, 8, 766, 769, Blackwell Publishing, 01 Aug. 2016, [Peer-reviewed]
English, Scientific journal

Overview.
Manabe A
[Rinsho ketsueki] The Japanese journal of clinical hematology, 57, 7, 881, Jul. 2016, [Peer-reviewed]

メルカプトプリンによる重度の血液毒性をきたしたNUDT15ホモバリアントを有する小児急性リンパ性白血病
木村 俊介, 長谷川 大輔, 吉本 優里, 平林 真介, 細谷 要介, 吉原 宏樹, 熊本 忠史, 田中 庸一, 真部 淳
臨床血液, 57, 6, 748, 753, (一社)日本血液学会-東京事務局, Jun. 2016
Japanese

治療方針に難渋したIgA血管炎に伴う腸重積の1例　　　　　　　　　　　　　　　
栗山 絢子, 真部 淳, 瀬谷 恵, 松井 俊大, 右田 美里, 迫田 晃子, 草川 功, 松藤 凡
日本小児救急医学会雑誌, 15, 2, 260, 260, (一社)日本小児救急医学会, Jun. 2016
Japanese

Secondary cancers after a childhood cancer diagnosis: a nationwide hospital-based retrospective cohort study in Japan
Yasushi Ishida, Dongmei Qiu, Miho Maeda, Junichiro Fujimoto, Hisato Kigasawa, Ryoji Kobayashi, Maho Sato, Jun Okamura, Shinji Yoshinaga, Takeshi Rikiishi, Hiroyuki Shichino, Chikako Kiyotani, Kazuko Kudo, Keiko Asami, Hiroki Hori, Hiroshi Kawaguchi, Hiroko Inada, Souichi Adachi, Atsushi Manabe, Tatsuo Kuroda
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 21, 3, 506, 516, Jun. 2016, [Peer-reviewed]
English, Scientific journal

Severe 6-mercaptopurine-induced hematotoxicity in childhood an ALL patient with homozygous NUDT15 missence variants.
Shunsuke Kimura, Daisuke Hasegawa, Yuri Yoshimoto, Shinsuke Hirabayashi, Yosuke Hosoya, Hiroki Yoshihara, Tadashi Kumamoto, Yoichi Tanaka, Atsushi Manabe
[Rinsho ketsueki] The Japanese journal of clinical hematology, 57, 6, 748, 53, 一般社団法人 日本血液学会, Jun. 2016, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, Thiopurine S-methyltransferase (TPMT) and nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) variants are considered to be genes responsible for severe myelotoxicity induced by 6-mercaptopurine (6MP). We report a 4-year-old girl with acute lymphoblastic leukemia, who developed the complication of severe 6MP-induced myelotoxicity due to homozygous NUDT15 variant alleles. In early consolidation therapy containing 6MP, her course was complicated by severe neutropenia (Grade 4) and chemotherapy had to be discontinued for 33 days. The 6MP dose was subsequently adjusted based on the white blood cell count. The ratios of the prescribed 6MP dose over the protocol dose in early consolidation, central nervous system (CNS) prophylaxis, re-induction, interim maintenance and maintenance therapy were 63%, 27%, 4%, 26% and 7%, respectively. Suspension of therapy was required during early consolidation, CNS prophylaxis and interim maintenance therapy. We investigated candidate genes for 6MP-associated myelotoxicity and found homozygous NUDT15 variant alleles and a heterozygous inosine triphosphate pyrophosphatase (ITPA) variant allele. In patients with homozygous NUDT15 variants, drastic reduction (less than 10%) of the 6MP dose from the protocol dose might be required not only during maintenance therapy, but also during other treatment courses containing 6MP. Screening of candidate genes at diagnosis is recommended in order to avoid serious adverse events.

Secondary cancers after a childhood cancer diagnosis: a nationwide hospital-based retrospective cohort study in Japan
Yasushi Ishida, Dongmei Qiu, Miho Maeda, Junichiro Fujimoto, Hisato Kigasawa, Ryoji Kobayashi, Maho Sato, Jun Okamura, Shinji Yoshinaga, Takeshi Rikiishi, Hiroyuki Shichino, Chikako Kiyotani, Kazuko Kudo, Keiko Asami, Hiroki Hori, Hiroshi Kawaguchi, Hiroko Inada, Souichi Adachi, Atsushi Manabe, Tatsuo Kuroda
International Journal of Clinical Oncology, 21, 3, 506, 516, Springer Tokyo, 01 Jun. 2016, [Peer-reviewed]
English, Scientific journal

先天性QT延長症候群と局在関連てんかんを合併したKCNQ1変異を認める女児例
代田 惇朗, 小野 林太郎, 荻原 正明, 平林 真介, 横山 美奈, 白井 丈晶, 小澤 美和, 草川 功, 真部 淳
脳と発達, 48, Suppl., S369, (一社)日本小児神経学会, May 2016

Characterization of pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia with kinase fusions in Japan
T. Imamura, N. Kiyokawa, M. Kato, C. Imai, Y. Okamoto, M. Yano, K. Ohki, Y. Yamashita, Y. Kodama, A. Saito, M. Mori, S. Ishimaru, T. Deguchi, Y. Hashii, Y. Shimomura, T. Hori, K. Kato, H. Goto, C. Ogawa, K. Koh, T. Taki, A. Manabe, A. Sato, A. Kikuta, S. Adachi, K. Horibe, A. Ohara, A. Watanabe, Y. Kawano, E. Ishii, H. Shimada
BLOOD CANCER JOURNAL, 6, May 2016
English, Scientific journal

A Cytokine-Based Diagnostic Program in Pediatric Aplastic Anemia and Hypocellular Refractory Cytopenia of Childhood
Shaimaa Elmahdi, Asahito Hama, Atsushi Manabe, Daisuke Hasegawa, Hideki Muramatsu, Atsushi Narita, Nobuhiru Nishio, Olfat Ismael, Nozomu Kawashima, Yusuke Okuno, Yinyan Xu, Xinan Wang, Yoshiyuki Takahashi, Masafumi Ito, Seiji Kojima
PEDIATRIC BLOOD & CANCER, 63, 4, 652, 658, Apr. 2016, [Peer-reviewed]
English, Scientific journal

Residual disease detected by multidimensional flow cytometry shows prognostic significance in childhood acute myeloid leukemia with intermediate cytogenetics and negative FLT3-ITD: a report from the Tokyo Children's Cancer Study Group
Dai Keino, Akitoshi Kinoshita, Daisuke Tomizawa, Hiroyuki Takahashi, Kohmei Ida, Hidemitsu Kurosawa, Kazutoshi Koike, Setsuo Ota, Noriyuki Iwasaki, Junya Fujimura, Yuki Yuza, Chikako Kiyotani, Shohei Yamamoto, Tomoo Osumi, Takahiro Ueda, Shinji Mochizuki, Keiichi Isoyama, Ryoji Hanada, Akio Tawa, Atsushi Manabe, Yoichi Toguchi, Akira Ohara
INTERNATIONAL JOURNAL OF HEMATOLOGY, 103, 4, 416, 422, Apr. 2016, [Peer-reviewed]
English, Scientific journal

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity
Takaya Moriyama, Rina Nishii, Virginia Perez-Andreu, Wenjian Yang, Federico Antillon Klussmann, Xujie Zhao, Ting-Nien Lin, Keito Hoshitsuki, Jacob Nersting, Kentaro Kihira, Ute Hofmann, Yoshihiro Komada, Motohiro Kato, Robert McCorkle, Lie Li, Katsuyoshi Koh, Cesar Rolando Najera, Shirley Kow-Yin Kham, Tomoya Isobe, Zhiwei Chen, Edwynn Kean-Hui Chiew, Deepa Bhojwani, Cynthia Jeffries, Yan Lu, Matthias Schwab, Hiroto Inaba, Ching-Hon Pui, Mary V. Relling, Atsushi Manabe, Hiroki Hori, Kjeld Schmiegelow, Allen E. J. Yeoh, William E. Evans, Jun J. Yang
NATURE GENETICS, 48, 4, 367, +, Apr. 2016, [Peer-reviewed]
English, Scientific journal

Guest Editorial: Inherited bone marrow failure and myelodysplasia in children: how much do we know about pediatric diseases?
Atsushi Manabe
International Journal of Hematology, 103, 4, 359, Springer Tokyo, 01 Apr. 2016, [Peer-reviewed]
English, Scientific journal

Residual disease detected by multidimensional flow cytometry shows prognostic significance in childhood acute myeloid leukemia with intermediate cytogenetics and negative FLT3-ITD: a report from the Tokyo Children's Cancer Study Group.
Dai Keino, Akitoshi Kinoshita, Daisuke Tomizawa, Hiroyuki Takahashi, Kohmei Ida, Hidemitsu Kurosawa, Kazutoshi Koike, Setsuo Ota, Noriyuki Iwasaki, Junya Fujimura, Yuki Yuza, Chikako Kiyotani, Shohei Yamamoto, Tomoo Osumi, Takahiro Ueda, Shinji Mochizuki, Keiichi Isoyama, Ryoji Hanada, Akio Tawa, Atsushi Manabe, Yoichi Toguchi, Akira Ohara
International journal of hematology, 103, 4, 416, 22, Apr. 2016, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Residual disease (RD) after induction chemotherapy may predict clinical outcome in acute myeloid leukemia (AML). In the present study, we investigated the prognostic significance of RD detected by multidimensional flow cytometry (MDF) among 34 children treated for AML in a clinical trial (JPLSG AML-05) in Japan. Bone marrow samples were analyzed at the points of the end of the first induction course (BMA-1) and second induction course (BMA-2) by MDF. RD was evaluated by detecting the immature cells showing abnormal antigen expression pattern; CD34(+), CD15(+), CD7(+). Thirteen (39.4 %) of 34 patients at BMA-1 and 8 (27.6 %) of 34 at BMA-2 had RD levels ≥0.1 %. There was no significant difference in 3y-EFS and 3y-OS between patients with RD levels ≥0.1 % and those with RD levels <0.1 % (53.8 versus 70.0 %, P = 0.30 and 50.0 versus 66.7 %, P = 0.27, respectively). However, IR cytogenetics and negative FLT3-ITD patients with RD levels ≥0.1 % exhibited significantly lower 3y-EFS and 3y-OS than those with RD levels <0.1 % (33.3 versus 83.3 %, P = 0.02 and 20.0 versus 76.9 %, P = 0.005, respectively). Our study suggests that RD shows prognostic relevance in pediatric patients with IR cytogenetics and negative FLT3-ITD AML.

A Cytokine-Based Diagnostic Program in Pediatric Aplastic Anemia and Hypocellular Refractory Cytopenia of Childhood
Shaimaa Elmahdi, Asahito Hama, Atsushi Manabe, Daisuke Hasegawa, Hideki Muramatsu, Atsushi Narita, Nobuhiru Nishio, Olfat Ismael, Nozomu Kawashima, Yusuke Okuno, Yinyan Xu, Xinan Wang, Yoshiyuki Takahashi, Masafumi Ito, Seiji Kojima
Pediatric Blood and Cancer, 63, 4, 652, 658, John Wiley and Sons Inc., 01 Apr. 2016, [Peer-reviewed]
English, Scientific journal

【小児慢性疾患の成人期移行の現状と問題点】 悪性新生物 血液腫瘍(白血病、悪性リンパ腫)
吉本 優里, 真部 淳
小児科臨床, 69, 4, 549, (株)日本小児医事出版社, Apr. 2016

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity
Takaya Moriyama, Rina Nishii, Virginia Perez-Andreu, Wenjian Yang, Federico Antillon Klussmann, Xujie Zhao, Ting-Nien Lin, Keito Hoshitsuki, Jacob Nersting, Kentaro Kihira, Ute Hofmann, Yoshihiro Komada, Motohiro Kato, Robert McCorkle, Lie Li, Katsuyoshi Koh, Cesar Rolando Najera, Shirley Kow-Yin Kham, Tomoya Isobe, Zhiwei Chen, Edwynn Kean-Hui Chiew, Deepa Bhojwani, Cynthia Jeffries, Yan Lu, Matthias Schwab, Hiroto Inaba, Ching-Hon Pui, Mary V Relling, Atsushi Manabe, Hiroki Hori, Kjeld Schmiegelow, Allen E.J. Yeoh, William E Evans, Jun J. Yang
Nature Genetics, 48, 4, 367, 373, Nature Publishing Group, 29 Mar. 2016, [Peer-reviewed]
English, Scientific journal

小児T細胞性ALLにおける既知遺伝子異常の解析 TCCSG-ALL研究　　　　　　　　　　　　　　　
大木 健太郎, 清河 信敬, 朴 明子, 小林 健一郎, 福島 敬, 康 勝好, 花田 良二, 林 泰秀, 真部 淳, 小原 明, 東京小児がん研究グループ
日本小児科学会雑誌, 120, 2, 259, 259, (公社)日本小児科学会, Feb. 2016
Japanese

Dosage of oral methotrexate/6-mercaptopurine in the maintenance treatment of childhood acute lymphoblastic leukemia: a single-center experience
Utano Tomoyuki, Tanaka Yoichi, Kizu Junko, Kamiya Takahiro, Ogawa Chitose, Ishida Yasushi, Hosoya Ryota, Manabe Atsushi
The Japanese Journal of Pediatric Hematology / Oncology, 52, 5, 399, 404, The Japanese Society of Pediatric Hematology / Oncology, Feb. 2016
Japanese, Background. Mercaptopurine (6-MP) and methotrexate (MTX) form the backbone of maintenance therapy for childhood acute lymphoblastic leukemia (ALL). It is widely noted that the inter- and intrapatient variations in the clinical efficacy and adverse effects of 6-MP and MTX are enormous, and optimal dosage varies considerably. The aim of this study was to elucidate the factors that affect the optimal dosage setting of 6-MP/MTX in the maintenance phase of treatment. Methods. Fifty children (aged 1 to 15) who were diagnosed as having ALL in our institution between April 1995 to March 2010 and who finished maintenance therapy were enrolled in this study. We investigated the 6-MP/MTX dosages from the beginning (6-MP/MTX: 40 mg/m² / 25 mg/m²) and compared patients' characteristics (sex, white blood cell count, age, immunophenotype, body surface area, prednisolone response, risk classification, obesity index) and relapse rates across each category. Results. Thirty-four patients needed to change their 6-MP dosage (increase, n=20; decrease, n=14), whereas 18 patients needed to change their MTX dosage (increase, n=3; decrease, n=15). The patients' characteristics were not significantly different in each category of dosage changes; on the other hand, it was shown that 4 of 7 relapse patients experienced an increase in 6-MP dosage of more than 50% within the first 6 months after the start of maintenance treatment. Conclusions. In this study, we conclude that the patients' characteristics are not related to the 6-MP/MTX dosage change in maintenance therapy, and it is suggested that the major increase in 6-MP dosage may predict the occurrence of relapse.

自閉症スペクトラム障害のフォロー中に発作時脳波での鑑別を要した前頭葉てんかん
角谷 和歌子, 代田 惇朗, 松井 俊大, 田中 育子, 横山 美奈, 長谷川 大輔, 小澤 美和, 荻原 正明, 草川 功, 真部 淳
日本小児科学会雑誌, 120, 2, 516, (公社)日本小児科学会, Feb. 2016

水痘感染の既往のない非血縁者間臍帯血移植後男児に生じた帯状疱疹
木村 俊介, 長谷川 大輔, 代田 惇朗, 松井 俊大, 吉本 優里, 平林 真介, 細谷 要介, 熊本 忠志, 真部 淳
日本小児科学会雑誌, 120, 2, 501, (公社)日本小児科学会, Feb. 2016

症例報告の書き方、査読の仕方 論文査読のしかた
真部 淳
日本小児科学会雑誌, 120, 2, 210, (公社)日本小児科学会, Feb. 2016

From a paper-based to a web-based Journal
Atsushi Manabe
PEDIATRICS INTERNATIONAL, 58, 1, 3, 3, Jan. 2016, [Peer-reviewed]
English

ZNF384-related fusion genes consist of a subgroup with a characteristic immunophenotype in childhood B-cell precursor acute lymphoblastic leukemia.
Hirabayashi Shinsuke, Ohki Kentaro, Nakabayashi Kazuhiko, Ichikawa Hitoshi, Momozawa Yukihide, Okamura Kohji, Yaguchi Akinori, Terada Kazuki, Saito Yuya, Yoshimi Ai, Ogata-Kawata Hiroko, Sakamoto Hiromi, Kato Motohiro, Fujimura Junya, Hino Moeko, Kinoshita Akitoshi, Kakuda Hiromi, Kurosawa Hidemitsu, Kato Keisuke, Kajiwara Ryosuke, Moriwaki Koichi, Morimoto Tsuyoshi, Nakamura Kozue, Noguchi Yasushi, Osumi Tomoo, Sakashita Kazuo, Takita Junko, Yuza Yuki, Matsuda Koich, Yoshida Teruhiko, Matsumoto Kenji, Hata Kenichiro, Kubo Michiaki, Matsubara Yoichi, Fukushima Takashi, Koh Katsuyoshi, Manabe Atsushi, Ohara Akira, Kiyokawa Nobutaka
ZNF384-related fusion genes consist of a subgroup with a characteristic immunophenotype in childhood B-cell precursor acute lymphoblastic leukemia., 2016
:Fusion genes involving ZNF384 have recently been identified in B-cell precursor acute lymphoblastic leukemia, and 6 fusion partners have reported. We further characterized this type of fusion gene by whole transcriptome sequencing and/or PCR. In addition to previously reported genes, we identified BMP2K as a novel fusion partner for ZNF384. Including EP300-ZNF384 that we reported recently, the to

メチルプレドニゾロン・パルス療法とタクロリムスによる治療が奏効した抗MDA5抗体陽性の若年性皮膚筋炎の女児例
山口 賢一, 横田 俊平, 代田 惇朗, 小澤 美和, 真部 淳, 草川 功
日本小児科学会雑誌, 120, 1, 96, (公社)日本小児科学会, Jan. 2016

Successful unrelated cord blood transplantation in a child with very severe aplastic anemia
Kimura Shunsuke, Hasegawa Daisuke, Matsui Toshihiro, Daida Atsuro, Ishida Hisashi, Yoshimoto Yuri, Hirabayashi Shinsuke, Hosoya Yosuke, Yoshihara Hiroki, Kumamoto Tadashi, Mori Shinichiro, Manabe Atsushi
The Japanese Journal of Pediatric Hematology / Oncology, 53, 1, 21, 25, The Japanese Society of Pediatric Hematology / Oncology, 2016
Japanese, Unrelated cord blood transplantation (UCBT) and mismatched related donor stem cell transplantation (MMRD-SCT) have been considered as alternative therapeutic options for patients with very severe aplastic anemia (VSAA) and severe infection when an HLA-matched donor is not available. However, a high rate of graft failure and severe graft-versus-host disease (GVHD) are the major problems in SCT from

A novel recurrent EP300-ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia
Y. Gocho, N. Kiyokawa, H. Ichikawa, K. Nakabayashi, T. Osumi, T. Ishibashi, H. Ueno, K. Terada, K. Oboki, H. Sakamoto, Y. Shioda, M. Imai, Y. Noguchi, Y. Arakawa, Y. Kojima, D. Toyama, K. Hata, T. Yoshida, K. Matsumoto, M. Kato, T. Fukushima, K. Koh, A. Manabe, A. Ohara
Leukemia, 29, 12, 2445, 2448, Nature Publishing Group, 01 Dec. 2015
English

英語論文の書き方
真部 淳
日本小児科学会雑誌, 119, 12, 1728, (公社)日本小児科学会, Dec. 2015

【小児血液・腫瘍性疾患の診断と治療のトピックス】 診断のトピックス 白血病とGWAS(genome-wide association study)
真部 淳
小児科診療, 78, 12, 1753, (株)診断と治療社, Dec. 2015
様々な疾患において宿主(患者)の生殖細胞系列の遺伝子変異を網羅的に検索するgenome-wide association study(GWAS:ゲノムワイド関連解析)が行われている。小児の急性リンパ性白血病(acute lymphoblastic leukemia:ALL)ではGWASにより、ALLのなりやすさと関連するARID5Bなどの遺伝子多型ならびに薬物の毒性と関連するNUDT15などの遺伝子多型がわかってきた。近い将来の臨床応用が期待される。(著者抄録)

Favorable outcome in non-infant children with MLL-AF4-positive acute lymphoblastic leukemia: a report from the Tokyo Children's Cancer Study Group.
Tomizawa D, Kato M, Takahashi H, Fujimura J, Inukai T, Fukushima T, Kiyokawa N, Koh K, Manabe A, Ohara A
International journal of hematology, 102, 5, 602, 610, Nov. 2015, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Unlike acute lymphoblastic leukemia (ALL) in infants, MLL gene rearrangement (MLL-r) is rare in ALL children (≥1 year old). The outcome and optimal treatment options for MLL-r ALL remain controversial. Among the 1827 children enrolled in the Tokyo Children's Cancer Study Group ALL studies L95-14, L99-15, L99-1502, L04-16, and L07-1602 (1995-2009), 25 MLL-r ALL patients (1.3 %) were identified. Their median age and leukocyte count at diagnosis was 2 years old (range 1-15 years) and 27,690/μL (range 1800-1,113,000/μL), respectively. All but one patient achieved complete remission (CR) after induction therapy, and 19 underwent allogeneic hematopoietic stem cell transplantation (HSCT) in first CR according to the protocol. The 5-year event-free survival (EFS) and overall survival (OS) rate were 60.0 % [standard error (SE), 9.7 %] and 64.0 % (SE 9.6 %), respectively. Notably, 9/12 cases with MLL-AF4-positive ALL are alive in continuous CR with a 75.0 % (SE 12.5 %) EFS rate. The causes of treatment failure were as follows: one induction failure, five relapses, and five transplant-related deaths. With intensive chemotherapy and allogeneic HSCT, favorable outcome of children (≥1 year old) with MLL-AF4-positive ALL was observed. However, considering the risk of acute and late toxicities associated with HSCT, its indication should be restricted.

融合遺伝子TCF3-ZNF384陽性B前駆細胞性急性リンパ芽球性白血病5例の臨床的特徴(Clinical characteristics of five cases of B-cell precursor acute lymphoblastic leukemia with TCF3-ZNF384 fusion gene)
平林 真介, 大木 健太郎, 清河 信敬, 谷口 明徳, 寺田 和樹, 市川 仁, 中林 一彦, 秦 健一郎, 松田 浩一, 桃沢 幸秀, 久保 充明, 松原 洋一, 福島 敬, 康 勝好, 真部 淳, 小原 明
日本小児血液・がん学会雑誌, 52, 4, 260, 260, (一社)日本小児血液・がん学会, Oct. 2015
English

小児T-ALLにおける6qLOHの頻度と予後解析 TCCSG ALL L0416/L0616(Frequency and prognostic impact of loss of heterozygosity at chromosome 6q in pediatric acute T-cell lymphoblastic leukemia: TCCSG ALL-L0416/L0616 Trial)
大木 健太郎, 清河 信敬, 朴 明子, 小林 健一郎, 福島 敬, 康 勝好, 土田 昌宏, 林 泰秀, 真部 淳, 小原 明
日本小児血液・がん学会雑誌, 52, 4, 267, 267, (一社)日本小児血液・がん学会, Oct. 2015
English

小児B前駆細胞性急性リンパ芽球性白血病における、PAX5の新規融合遺伝子CBFA2T2の同定(Identification of CBFA2T2 as a novel PAX5 fusion partner gene in pediatric B-precursor acute lymphoblastic leukemia)
寺田 和樹, 清河 信敬, 大木 健太郎, 木川 崇, 櫻井 彩子, 五十嵐 俊二, 谷口 明徳, 石橋 武士, 中林 一彦, 市川 仁, 松本 健治, 福島 敬, 康 勝好, 真部 淳, 小原 明, 角南 勝介
日本小児血液・がん学会雑誌, 52, 4, 349, 349, (一社)日本小児血液・がん学会, Oct. 2015
English

TCCSG施設ならびにTCCSG医師における小児がん晩期合併症の経験に関する調査
清谷 知賀子, 前田 美穂, 青木 由貴, 加藤 陽子, 後藤 晶子, 坂口 佐知, 徳山 美香, 石井 栄三郎, 石田 也寸志, 中舘 尚也, 真部 淳, 小原 明, 東京小児がん研究グループ(TCCSG)QOL委員会
日本小児血液・がん学会雑誌, 52, 4, 345, 345, (一社)日本小児血液・がん学会, Oct. 2015
Japanese

Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia
Yoichi Tanaka, Motohiro Kato, Daisuke Hasegawa, Kevin Y. Urayama, Hisaya Nakadate, Kensuke Kondoh, Kozue Nakamura, Katsuyoshi Koh, Takako Komiyama, Atsushi Manabe
BRITISH JOURNAL OF HAEMATOLOGY, 171, 1, 109, 115, Oct. 2015, [Peer-reviewed]
English, Scientific journal

Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia
Yoichi Tanaka, Motohiro Kato, Daisuke Hasegawa, Kevin Y. Urayama, Hisaya Nakadate, Kensuke Kondoh, Kozue Nakamura, Katsuyoshi Koh, Takako Komiyama, Atsushi Manabe
British Journal of Haematology, 171, 1, 109, 115, Blackwell Publishing Ltd, 01 Oct. 2015, [Peer-reviewed]
English, Scientific journal

ダサチニブ投与中に両側肺下胸水を認めたフィラデルフィア染色体陽性急性リンパ性白血病の男児
吉本 優里, 熊本 忠史, 木村 俊介, 平林 真介, 細谷 要介, 長谷川 大輔, 真部 淳
日本小児血液・がん学会雑誌, 52, 4, 309, (NPO)日本小児血液・がん学会, Oct. 2015

VincristineとActinomycin Dによる化学療法が奏効し下肢切断を免れているinfantile fibrosarcomaの一例
細谷 要介, 吉本 優里, 吉原 宏樹, 長谷川 大輔, 熊本 忠史, 川野 孝文, 迫田 晃子, 松藤 凡, 真部 淳
日本小児血液・がん学会雑誌, 52, 4, 304, (NPO)日本小児血液・がん学会, Oct. 2015

体細胞ヘテロ接合性CBL変異が長期に残存したJMML(Long-term persistence of somatic heterozygous CBL mutation in JMML)
平林 真介, 長谷川 大輔, 周尾 卓也, 村松 秀城, 坂下 一夫, 小島 勢二, 小池 健一, 真部 淳
日本小児血液・がん学会雑誌, 52, 4, 277, (NPO)日本小児血液・がん学会, Oct. 2015

小児悪性腫瘍患者におけるClostridium Difficile腸炎のリスク(Risk factors for Clostridium difficile associated diarrhea among pediatric cancer patients)
代田 惇朗, 吉原 宏樹, 稲井 郁子, 吉本 優里, 平林 真介, 細谷 要介, 長谷川 大輔, 石田 也寸志, 浦山 ケビン, 真部 淳
日本小児血液・がん学会雑誌, 52, 4, 243, (NPO)日本小児血液・がん学会, Oct. 2015

再生不良性貧血・骨髄増殖性疾患 治療関連骨髄異形成症候群44例の臨床像(Aplastic anemia and myeloproliferative disorder Clinical characteristics of 44 cases with therapy-related myelodysplastic syndrome in childhood)
長谷川 大輔, 濱 麻人, 野沢 和江, 平林 真介, 渡邉 健一郎, 土田 昌宏, 伊藤 雅文, 小島 勢二, 中畑 龍俊, 真部 淳
日本小児血液・がん学会雑誌, 52, 4, 208, (NPO)日本小児血液・がん学会, Oct. 2015

わが国の小児がん医療提供体制について考える 小児がんに対するトータルケアと医療提供体制
長谷川 大輔, 小澤 美和, 真部 淳, 細谷 亮太
日本小児血液・がん学会雑誌, 52, 4, 189, (NPO)日本小児血液・がん学会, Oct. 2015

Favorable outcome in non-infant children with MLL-AF4-positive acute lymphoblastic leukemia: a report from the Tokyo Children’s Cancer Study Group
Daisuke Tomizawa, Motohiro Kato, Hiroyuki Takahashi, Junya Fujimura, Takeshi Inukai, Takashi Fukushima, Nobutaka Kiyokawa, Katsuyoshi Koh, Atsushi Manabe, Akira Ohara
International Journal of Hematology, 102, 5, 602, 610, Springer-Verlag Tokyo, 26 Sep. 2015, [Peer-reviewed]
English, Scientific journal

Outcome of adolescent patients with acute myeloid leukemia treated with pediatric protocols
Daisuke Tomizawa, Tomoyuki Watanabe, Ryoji Hanada, Keizo Horibe, Yasuo Horikoshi, Shotaro Iwamoto, Akitoshi Kinoshita, Hiroshi Moritake, Hideki Nakayama, Akira Shimada, Takashi Taga, Hiroyuki Takahashi, Akio Tawa, Kiminori Terui, Hiroki Hori, Yoshifumi Kawano, Atsushi Kikuta, Atsushi Manabe, Souichi Adachi
INTERNATIONAL JOURNAL OF HEMATOLOGY, 102, 3, 318, 326, Sep. 2015, [Peer-reviewed]
English, Scientific journal

肋骨の多発溶骨性変化をきたしているGorham病の発症10年後の呼吸機能
梅原 直, 熊本 忠史, 真部 淳
日本小児呼吸器学会雑誌, 26, Suppl., 147, 日本小児呼吸器学会, Sep. 2015

【内科が使う自己注射薬】 血液に作用する自己注射薬 G-CSF製剤の在宅自己注射
平林 真介, 真部 淳
診断と治療, 103, 9, 1223, (株)診断と治療社, Sep. 2015
1 G-CSF製剤は骨髄前駆細胞から顆粒球への増殖分化を促すと同時に顆粒球の機能を高めるバイオ医薬品であり、幅広く臨床応用されている。2 再生不良性貧血と先天性好中球減少症においてG-CSF製剤は有意に感染が減少し、在宅自己注射の適応が承認された。3 G-CSF製剤の長期投与に伴いMDS/AMLへの移行が報告されており、漫然とした使用は避ける必要がある。(著者抄録)

Multidrug resistance protein 4 (MRP4) polymorphisms impact the 6-mercaptopurine dose tolerance during maintenance therapy in Japanese childhood acute lymphoblastic leukemia
Y. Tanaka, A. Manabe, H. Fukushima, R. Suzuki, H. Nakadate, K. Kondoh, K. Nakamura, K. Koh, T. Fukushima, M. Tsuchida, K. Koike, N. Kiyokawa, E. Noguchi, R. Sumazaki, T. Komiyama
Pharmacogenomics Journal, 15, 4, 380, 384, Nature Publishing Group, 25 Aug. 2015
English, Scientific journal

Review article series on the state of recent evidence in childhood cancer
Atsushi Manabe
PEDIATRICS INTERNATIONAL, 57, 4, 515, 515, Aug. 2015, [Peer-reviewed]
English

Cytogenetics and clinical features of pediatric myelodysplastic syndrome in Japan (vol 100, pg 478, 2014)
Koichi Moriwaki, Atsushi Manabe, Takeshi Taketani, Akira Kikuchi, Tatsutoshi Nakahata, Yasuhide Hayashi
INTERNATIONAL JOURNAL OF HEMATOLOGY, 102, 2, 249, 249, Aug. 2015, [Peer-reviewed]
English

Multidrug resistance protein 4 (MRP4) polymorphisms impact the 6-mercaptopurine dose tolerance during maintenance therapy in Japanese childhood acute lymphoblastic leukemia
Y. Tanaka, A. Manabe, H. Fukushima, R. Suzuki, H. Nakadate, K. Kondoh, K. Nakamura, K. Koh, T. Fukushima, M. Tsuchida, K. Koike, N. Kiyokawa, E. Noguchi, R. Sumazaki, T. Komiyama
PHARMACOGENOMICS JOURNAL, 15, 4, 380, 384, Aug. 2015, [Peer-reviewed]
English, Scientific journal

CD10陰性B前駆細胞性急性リンパ芽球性白血病の新たな亜群EP300-ZNF384　　　　　　　　　　　　　　　
寺田 和樹, 清河 信敬, 牛腸 義宏, 谷口 明徳, 石橋 武士, 橋本 亙, 大隅 朋生, 大木 健太郎, 福島 敬, 康 勝好, 真部 淳, 小原 明
Cytometry Research, 25, Suppl., 56, 56, (一社)日本サイトメトリー学会, Jul. 2015
Japanese

消化管出血を呈した青色ゴムまり様母斑症候群の1例
栗山 絢子, 石田 悠志, 吉本 優里, 平林 真介, 細谷 要介, 吉原 宏樹, 長谷川 大輔, 真部 淳
日本小児科学会雑誌, 119, 6, 1029, (公社)日本小児科学会, Jun. 2015

Long-term outcome of six months maintenance chemotherapy for ALL in children: TCCSG L92-13E study.
Motohiro Kato, Atsushi Manabe, Sae Ishimaru, Masafumi Seki, Kenichi Yoshida, Daisuke Tomizawa, Daisuke Hasegawa, Takeshi Inukai, Yuki Arakawa, Takahiro Aoki, Mayuko Okuya, Kiyohiko Kaizu, Keisuke Kato, Yuichi Taneyama, Seishi Ogawa, Katsuyoshi Koh, Masahiro Tsuchida, Akira Ohara
JOURNAL OF CLINICAL ONCOLOGY, 33, 15, May 2015, [Peer-reviewed]
English

Imatinib use immediately before stem cell transplantation in children with Philadelphia chromosome-positive acute lymphoblastic leukemia: Results from Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) Study Ph(+)ALL04
Atsushi Manabe, Hirohide Kawasaki, Hiroyuki Shimada, Itaru Kato, Yuichi Kodama, Atsushi Sato, Kimikazu Matsumoto, Keisuke Kato, Hiromasa Yabe, Kazuko Kudo, Motohiro Kato, Tomohiro Saito, Akiko M. Saito, Masahito Tsurusawa, Keizo Horibe
CANCER MEDICINE, 4, 5, 682, 689, May 2015, [Peer-reviewed]
English, Scientific journal

周期性好中球減少症合併患者に婦人科手術を施行した一例
大垣 洋子, 塩田 恭子, 山田 梨紗子, 和泉 紀子, 岩瀬 純, 水野 吉章, 秋谷 文, 平林 真介, 真部 淳
日本産婦人科・新生児血液学会誌, 25, 1, 32, 日本産婦人科・新生児血液学会, May 2015
42歳(0回経妊婦)。周期性好中球減少症の既往があり、今回、卵巣嚢腫摘出術および子宮筋腫核出術目的に当科入院となった。約2ヵ月にわたり好中球の変動を確認し、最低値の時期を過ぎる頃に手術日を設定したが、予定日の3日前よりG-CSF製剤を投与するも好中球数は改善せず、手術は延期となった。遺伝子検査でELA2変異を認め、G-CSF製剤が有効な型であったため、再度手術日を設定し8日前よりG-CSF製剤の投与を行った。周術期の予防的抗生剤はVCM、CFPM、MNZの点滴とし、右卵巣嚢腫摘出と子宮筋腫核出術を施行し得た。術後の経過は良好で、術後5日目に軽快退院した。

Psychosocial difficulties in adolescent and young adult survivors of childhood cancer
Yuko Takei, Akiko Ogata, Miwa Ozawa, Hiroshi Moritake, Kei Hirai, Atsushi Manabe, Shin-ichi Suzuki
PEDIATRICS INTERNATIONAL, 57, 2, 239, 246, Apr. 2015, [Peer-reviewed]
English, Scientific journal

Acute megakaryoblastic leukemia with acquired trisomy 21 and GATA1 mutations in phenotypically normal children
Rintaro Ono, Daisuke Hasegawa, Shinsuke Hirabayashi, Takahiro Kamiya, Kenichi Yoshida, Satoko Yonekawa, Chitose Ogawa, Ryota Hosoya, Tsutomu Toki, Kiminori Terui, Etsuro Ito, Atsushi Manabe
EUROPEAN JOURNAL OF PEDIATRICS, 174, 4, 525, 531, Apr. 2015, [Peer-reviewed]
English, Scientific journal

Acute megakaryoblastic leukemia with acquired trisomy 21 and GATA1 mutations in phenotypically normal children.
Rintaro Ono, Daisuke Hasegawa, Shinsuke Hirabayashi, Takahiro Kamiya, Kenichi Yoshida, Satoko Yonekawa, Chitose Ogawa, Ryota Hosoya, Tsutomu Toki, Kiminori Terui, Etsuro Ito, Atsushi Manabe
European journal of pediatrics, 174, 4, 525, 31, Apr. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal, UNLABELLED: GATA1 mutations are found almost exclusively in children with myeloid proliferations related to Down syndrome (DS). Here, we report two phenotypically and cytogenetically normal children with acute megakaryoblastic leukemia (AMKL) whose blasts had both acquired trisomy 21 and GATA1 mutation. Patient 1 was diagnosed with transient abnormal myelopoiesis in the neonatal period. Following spontaneous improvement of the disease, leukemic blasts increased 7 months later. He received less intensive chemotherapy, and he is now 6 years old in complete remission. Patient 2 was diagnosed with AMKL at the age of 18 months. Although he received intensive chemotherapy and a cord blood transplantation, he died without gaining remission. In both cases, trisomy 21 and GATA1 mutation were detected only in leukemic blasts, but not in germline samples. Based on a literature review, we identified reports describing 14 non-DS AMKL with GATA1 mutation and acquired trisomy 21. Of those, 12 cases were diagnosed during the neonatal period, whereas the remaining 2 cases were diagnosed at the age of 22 and 31 months, respectively. CONCLUSION: These cases suggest that GATA1 mutation may cooperate with the additional chromosome 21 in developing myeloid proliferations even in non-DS patients.

小児がん治療の最前線 Pharmacogenomics and Translational Medicine
真部 淳
日本薬学会年会要旨集, 135年会, 1, 348, (公社)日本薬学会, Mar. 2015

小児がん治療30年間の進歩 予後の改善と患者・家族への支援
真部 淳
聖路加国際大学紀要, 1, 29, 聖路加国際大学, Mar. 2015

小児科領域の国際専門誌に論文を掲載するコツ
真部 淳
小児科, 56, 3, 311, 金原出版(株), Mar. 2015

Transplantation for juvenile myelomonocytic leukemia: a retrospective study of 30 children treated with a regimen of busulfan, fludarabine, and melphalan
Miharu Yabe, Yoshitoshi Ohtsuka, Kenichiro Watanabe, Jiro Inagaki, Nao Yoshida, Kazuo Sakashita, Harumi Kakuda, Hiromasa Yabe, Hidemitsu Kurosawa, Kazuko Kudo, Atsushi Manabe
INTERNATIONAL JOURNAL OF HEMATOLOGY, 101, 2, 184, 190, Feb. 2015, [Peer-reviewed]
English, Scientific journal

無呼吸、重症下気道感染を来したHuman Rhinovirusの乳児3例
代田 惇朗, 辻本 信一, 稲井 郁子, 吉本 優里, 石田 悠志, 野村 耕太郎, 梅原 直, 小澤 美和, 真部 淳, 草川 功
日本小児科学会雑誌, 119, 2, 511, 511, (公社)日本小児科学会, Feb. 2015
Japanese

消化管出血を呈したBlue rubber bleb nevus syndromeの一例
栗山 絢子, 吉本 優里, 平林 真介, 長谷川 大輔, 小澤 美和, 草川 功, 真部 淳, 嶋田 明, 末延 聡一
日本小児科学会雑誌, 119, 2, 419, 419, (公社)日本小児科学会, Feb. 2015
Japanese

頸部リンパ節炎の治療に難渋した自己免疫性好中球減少症の2例
吉本 優里, 代田 惇朗, 平林 真介, 長沖 優子, 細谷 要介, 長谷川 大輔, 稲井 郁子, 小澤 美和, 草川 功, 真部 淳
日本小児科学会雑誌, 119, 2, 414, (公社)日本小児科学会, Feb. 2015

英語論文の書き方
真部 淳
日本小児科学会雑誌, 119, 2, 167, (公社)日本小児科学会, Feb. 2015

Outcome of pediatric acute lymphoblastic leukemia with very late relapse: a retrospective analysis by the Tokyo Children's Cancer Study Group (TCCSG)
Motohiro Kato, Atsushi Manabe, Akiko M. Saito, Katsuyoshi Koh, Takeshi Inukai, Chitose Ogawa, Hiroyuki Goto, Masahiro Tsuchida, Akira Ohara
INTERNATIONAL JOURNAL OF HEMATOLOGY, 101, 1, 52, 57, Jan. 2015, [Peer-reviewed]
English, Scientific journal

Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia
Charlotte M. Niemeyer, Mignon L. Loh, Annamaria Cseh, Todd Cooper, Christopher C. Dvorak, Rebecca Chan, Blanca Xicoy, Ulrich Germing, Seiji Kojima, Atsushi Manabe, Michael Dworzak, Barbara De Moerloose, Jan Stary, Owen P. Smith, Riccardo Masetti, Albert Catala, Eva Bergstraesser, Marek Ussowicz, Oskana Fabri, Andre Baruchel, Helene Cave, Michel Zwaan, Franco Locatelli, Henrik Hasle, Marry M. van den Heuvel-Eibrink, Christian Flotho, Ayami Yoshimi
HAEMATOLOGICA, 100, 1, 17, 22, Jan. 2015, [Peer-reviewed]
English, Scientific journal

Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia
Charlotte M. Niemeyer, Mignon L. Loh, Annamaria Cseh, Todd Cooper, Christopher C. Dvorak, Rebecca Chan, Blanca Xicoy, Ulrich Germing, Seiji Kojima, Atsushi Manabe, Michael Dworzak, Barbara De Moerloose, Jan Starý, Owen P. Smith, Riccardo Masetti, Albert Catala, Eva Bergstraesser, Marek Ussowicz, Oskana Fabri, André Baruchel, Hélène Cavé, Michel Zwaan, Franco Locatelli, Henrik Hasle, Marry M. Van Den Heuvel-Eibrink, Christian Flotho, Ayami Yoshimi
Haematologica, 100, 1, 17, 22, Ferrata Storti Foundation, 2015, [Peer-reviewed]
English, Scientific journal

Dosage of oral methotrexate/6-mercaptopurine in the maintenance treatment of childhood acute lymphoblastic leukemia: a single-center experience
Utano Tomoyuki, Tanaka Yoichi, Kizu Junko, Kamiya Takahiro, Ogawa Chitose, Ishida Yasushi, Hosoya Ryota, Manabe Atsushi
The Japanese Journal of Pediatric Hematology / Oncology, 52, 5, 399, 404, The Japanese Society of Pediatric Hematology / Oncology, 2015
Japanese, Background. Mercaptopurine (6-MP) and methotrexate (MTX) form the backbone of maintenance therapy for childhood acute lymphoblastic leukemia (ALL). It is widely noted that the inter- and intrapatient variations in the clinical efficacy and adverse effects of 6-MP and MTX are enormous, and optimal dosage varies considerably. The aim of this study was to elucidate the factors that affect the optimal

Long-Term Outcome of Six Months Maintenance Chemotherapy for ALL in Children: An Extended Follow up Study of TCCSG L92-13
Motohiro Kato, Atsushi Manabe, Sae Ishimaru, Daisuke Tomizawa, Daisuke Hasegawa, Takeshi Inukai, Yuki Arakawa, Takahiro Aoki, Mayuko Okuya, Kiyohiko Kaizu, Keisuke Kato, Yuichi Taneyama, Katsuyoshi Koh, Masahiro Tsuchida, Akira Ohara
BLOOD, 124, 21, Dec. 2014, [Peer-reviewed]
English

Hematopoietic Stem Cell Transplantation for Patients with Refractory Cytopenia of Childhood
Daisuke Hasegawa, Shinsuke Hirabayashi, Shizuka Watanabe, Yuji Zaike, Masahiro Tsuchida, Atsuko Masunaga, Ayami Yoshimi, Asahito Hama, Seiji Kojima, Masafumi Ito, Tatsutoshi Nakahata, Atsushi Manabe
BLOOD, 124, 21, Dec. 2014, [Peer-reviewed]
English

集学的治療を行った仙尾部原発卵黄嚢腫瘍の1例
上野 浩生, 長谷川 大輔, 辻本 信一, 小野 林太郎, 吉本 優里, 細谷 要介, 吉原 宏樹, 熊本 忠史, 川野 孝文, 迫田 晃子, 野崎 太希, 関口 建次, 中面 哲也, 真部 淳
日本小児血液・がん学会雑誌, 51, 5, 569, (NPO)日本小児血液・がん学会, Dec. 2014

Cytogenetics and clinical features of pediatric myelodysplastic syndrome in Japan
Koichi Moriwaki, Atsushi Manabe, Takeshi Taketani, Akira Kikuchi, Tatsutoshi Nakahata, Yasuhide Hayashi
INTERNATIONAL JOURNAL OF HEMATOLOGY, 100, 5, 478, 484, Nov. 2014, [Peer-reviewed]
English, Scientific journal

【難治性貧血-診断と病態・治療の進歩-】 小児科領域貧血の診断と病態・治療の進歩 先天性疾患
真部 淳
最新医学, 69, 11, 2159, (株)最新医学社, Nov. 2014
小児の先天性骨髄不全は,頻度はまれながら多くの疾患がある.先天性骨髄不全症候群は臨床症状や通常の臨床検査では診断が困難であり,遺伝子の検索が重要であるが,近年多くの疾患で責任遺伝子が同定されてきた.小児の先天性骨髄不全症候群は再生不良性貧血あるいは骨髄異形成症候群とのオーバーラップも多く,中央診断を通じた丁寧な診断と多施設共同治療研究が必須である.(著者抄録)

無症候の母から出生した新生児ループスの1例
岡崎 幹子, 吉本 優里, 代田 惇朗, 石田 悠志, 島袋 林秀, 稲井 郁子, 小澤 美和, 草川 功, 真部 淳
日本小児科学会雑誌, 118, 11, 1667, (公社)日本小児科学会, Nov. 2014

【急性リンパ性白血病をめぐる最近の進歩】 小児急性リンパ性白血病の治療戦略
石田 悠志, 真部 淳
血液内科, 69, 5, 637, (有)科学評論社, Nov. 2014

小児がん診断後の二次がん発症に関する疫学研究 15病院における後ろ向きコホート(Secondary cancers after cancer diagnosis in childhood: A hospital-based retrospective cohort study in Japan)
石田 也寸志, 邱 冬梅, 前田 美穂, 藤本 純一郎, 気賀沢 寿人, 小林 良二, 佐藤 真穂, 岡村 純, 吉永 信治, 力石 健, 七野 浩之, 清谷 知賀子, 工藤 寿子, 浅見 恵子, 堀 浩樹, 川口 浩史, 稲田 浩子, 足立 壮一, 真部 淳, 黒田 達夫
日本小児血液・がん学会雑誌, 51, 4, 261, 261, (一社)日本小児血液・がん学会, Oct. 2014
English

小児がん患児のきょうだいと母親のサポート知覚の特徴
長尾 愛美, 小澤 美和, 小川 祐子, 武井 優子, 竹内 恵美, 長谷川 由美, 真部 淳, 鈴木 伸一
日本小児血液・がん学会雑誌, 51, 4, 375, 375, (一社)日本小児血液・がん学会, Oct. 2014
Japanese

長期入院中の兄弟に対する集学的サポート(part 1) PedsQL 4.0総合コア尺度を用いた兄弟のQOL評価(Multidisciplinary support for siblings of long-term inpatients(part 1): Evaluation of siblings' quality of life using the PedsQL 4.0 Generic Core Scales)
野村 耕太郎, 若林 優, 植松 温子, 春山 智恵子, 三浦 絵莉子, 石田 智美, 後藤 真弥, 北川 千恵, 山本 光映, 小澤 美和, 真部 淳
日本小児血液・がん学会雑誌, 51, 4, 375, 375, (一社)日本小児血液・がん学会, Oct. 2014
English

高機能自閉症スペクトラム障害を抱える3歳男児の、入院中の心理的支援 骨髄移植をチームで支える
阿佐美 百合子, 春山 智恵子, 後藤 真弥, 北川 知恵, 熊谷 祐美, 平田 美佳, 山本 光映, 小澤 美和, 長谷川 大輔, 真部 淳
日本小児血液・がん学会雑誌, 51, 4, 374, (NPO)日本小児血液・がん学会, Oct. 2014

神経下垂体部胚細胞腫瘍の化学療法中に点鼻あるいは経口デスモプレシン製剤を用いて尿崩症管理を行った5例
木村 俊介, 細谷 要介, 石田 悠志, 野村 耕太郎, 吉本 優里, 吉原 宏樹, 長谷川 大輔, 伊藤 純子, 真部 淳
日本小児血液・がん学会雑誌, 51, 4, 335, (NPO)日本小児血液・がん学会, Oct. 2014

小児がん患者における長期留置型中心静脈カテーテル合併症のリスクファクターについて(Risk factors of long-term central venous catheters (CVCS) complication in children with hemato-oncological disorders)
迫田 晃子, 川野 孝文, 細谷 要介, 吉原 宏樹, 平林 真介, 長谷川 大輔, 小澤 美和, 真部 淳, 松藤 凡
日本小児血液・がん学会雑誌, 51, 4, 334, 334, (一社)日本小児血液・がん学会, Oct. 2014
English

当院で経験した神経芽腫Stage 4Sの2例
吉本 優里, 野村 耕太郎, 石田 悠志, 平林 真介, 細谷 要介, 吉原 宏樹, 長谷川 大輔, 細谷 亮太, 真部 淳
日本小児血液・がん学会雑誌, 51, 4, 287, (NPO)日本小児血液・がん学会, Oct. 2014

急性前骨髄球性白血病M3 variantの2例
石田 悠志, 松井 俊大, 木村 俊介, 野村 耕太郎, 吉本 優里, 平林 真介, 細谷 要介, 吉原 宏樹, 長谷川 大輔, 熊本 忠史, 真部 淳
日本小児血液・がん学会雑誌, 51, 4, 269, (NPO)日本小児血液・がん学会, Oct. 2014

多職種による長期入院児のきょうだい支援(part 2) きょうだいと医療者、きょうだい同士をつなげる取り組み(Multidisciplinary team approach to sibling support: The bridge-building of siblings, and of siblings and medical staff)
若林 優, 植松 温子, 春山 智恵子, 三浦 絵莉子, 石田 智美, 後藤 真弥, 北川 千恵, 野村 耕太郎, 山本 光映, 真部 淳, 小澤 美和
日本小児血液・がん学会雑誌, 51, 4, 259, 259, (一社)日本小児血液・がん学会, Oct. 2014
English

小児がん患者における精神身体症状発現のリスク因子の検討(Risk factors for psychosomatic symptoms among pediatric cancer patients)
前田 謙一, 辻本 信一, 長谷川 大輔, 浦山 ケビン, 阿佐美 百合子, 小澤 美和, 真部 淳
日本小児血液・がん学会雑誌, 51, 4, 258, 258, (一社)日本小児血液・がん学会, Oct. 2014
English

消化管出血を伴う青色ゴムまり様母斑症候群の乳児例(An infant of blue rubber bleb nevus syndrome with gastrointestinal bleeding)
平林 真介, 栗山 絢子, 石田 悠志, 吉本 優里, 細谷 要介, 吉原 宏樹, 川野 孝文, 迫田 晃子, 森田 有香, 中村 仁美, 衛藤 光, 鈴木 高祐, 末延 聡一, 長谷川 大輔, 真部 淳
日本小児血液・がん学会雑誌, 51, 4, 242, (NPO)日本小児血液・がん学会, Oct. 2014

【小児血液疾患-よくわかる最新知見-】 造血器悪性疾患 若年性骨髄単球性白血病
平林 真介, 真部 淳
小児科, 55, 11, 1745, 金原出版(株), Oct. 2014

Genomic evaluations of childhood acute lymphoblastic leukemia susceptibility across race/ethnicities
URAYAMA Kevin Y, MANABE Atsushi
Rinsho Ketsueki, 55, 10, 2242, 2248, The Japanese Society of Hematology, Oct. 2014, [Peer-reviewed]

Clinical characteristics and treatment outcome in 65 cases with refractory cytopenia of childhood defined according to the WHO 2008 classification
Daisuke Hasegawa, Xiaojuan Chen, Shinsuke Hirabayashi, Yasushi Ishida, Shizuka Watanabe, Yuji Zaike, Masahiro Tsuchida, Atsuko Masunaga, Ayami Yoshimi, Asahito Hama, Seiji Kojima, Masafumi Ito, Tatsutoshi Nakahata, Atsushi Manabe
BRITISH JOURNAL OF HAEMATOLOGY, 166, 5, 758, 766, Sep. 2014, [Peer-reviewed]
English, Scientific journal

Clinical characteristics and treatment outcome in 65 cases with refractory cytopenia of childhood defined according to the WHO 2008 classification.
Daisuke Hasegawa, Xiaojuan Chen, Shinsuke Hirabayashi, Yasushi Ishida, Shizuka Watanabe, Yuji Zaike, Masahiro Tsuchida, Atsuko Masunaga, Ayami Yoshimi, Asahito Hama, Seiji Kojima, Masafumi Ito, Tatsutoshi Nakahata, Atsushi Manabe
British journal of haematology, 166, 5, 758, 66, Sep. 2014, [Peer-reviewed], [International Magazine]
English, Scientific journal, This study analysed 65 children who were prospectively registered between 1999 and 2008 and fulfilled the World Health Organization 2008 criteria of refractory cytopenia of childhood (RCC). First-line therapy was determined by the treating physicians: 25 patients received immunosuppressive therapy (IST), 12 patients received haematopoietic stem cell transplantation (HSCT) and one patient received intensive chemotherapy. The remaining 27 patients were followed without treatment for more than 2 years (watch and wait; WW). In the WW group, 18 patients had stable disease without further intervention. Thirteen of 29 patients (45%) who ended up receiving IST showed response. The combination of ciclosporin and antithymocyte globulin was not shown to be superior to ciclosporin alone with regard to response rate or survival. Of 28 patients who ended up undergoing HSCT, 17 patients are alive in complete remission, whereas nine patients died mostly due to transplantation-related mortality. The 5-year overall survival for all patients was 82 ± 5%. Eight patients suffered from disease progression. Patients with monosomy 7 or multilineage-dysplasia had a significantly higher incidence of disease progression. This analysis revealed heterogeneity in the clinical course of RCC, varying from those who remained stable for long periods to those who progressed to advanced disease.

Treatment outcomes of adolescent acute lymphoblastic leukemia treated on Tokyo Children's Cancer Study Group (TCCSG) clinical trials
Motohiro Kato, Atsushi Manabe, Katsuyoshi Koh, Takeshi Inukai, Nobutaka Kiyokawa, Takashi Fukushima, Hiroaki Goto, Daisuke Hasegawa, Chitose Ogawa, Kazutoshi Koike, Setsuo Ota, Yasushi Noguchi, Akira Kikuchi, Masahiro Tsuchida, Akira Ohara
INTERNATIONAL JOURNAL OF HEMATOLOGY, 100, 2, 180, 187, Aug. 2014, [Peer-reviewed]
English, Scientific journal

Prognostic impact of gained chromosomes in high-hyperdiploid childhood acute lymphoblastic leukaemia: a collaborative retrospective study of the Tokyo Children's Cancer Study Group and Japan Association of Childhood Leukaemia Study
Motohiro Kato, Toshihiko Imamura, Atsushi Manabe, Yoshiko Hashii, Katsuyoshi Koh, Atsushi Sato, Hiroyuki Takahashi, Hiroki Hori, Tomohiko Taki, Masami Inoue, Yasuhide Hayashi, Keizo Horibe, Masahiro Tsuchida, Seiji Kojima, Megumi Oda, Akira Ohara
BRITISH JOURNAL OF HAEMATOLOGY, 166, 2, 295, 298, Jul. 2014, [Peer-reviewed]
English

Clinicians' perspectives on support for children with a parent who is diagnosed with breast cancer
Yuko Takei, Miwa Ozawa, Yasushi Ishida, Shin-ichi Suzuki, Shinji Ohno, Atsushi Manabe
BREAST CANCER, 21, 4, 463, 471, Jul. 2014, [Peer-reviewed]
English, Scientific journal

Clinical characteristics of 15 children with juvenile myelomonocytic leukaemia who developed blast crisis: MDS Committee of Japanese Society of Paediatric Haematology/Oncology
Yuko Honda, Masahiro Tsuchida, Yuji Zaike, Atsuko Masunaga, Ayami Yoshimi, Seiji Kojima, Masafumi Ito, Akira Kikuchi, Tatsutoshi Nakahata, Atsushi Manabe
BRITISH JOURNAL OF HAEMATOLOGY, 165, 5, 682, 687, Jun. 2014, [Peer-reviewed]
English, Scientific journal

Methylenetetrahydrofolate reductase gene haplotypes affect toxicity during maintenance therapy for childhood acute lymphoblastic leukemia in Japanese patients
Yoichi Tanaka, Atsushi Manabe, Hisaya Nakadate, Kensuke Kondoh, Kozue Nakamura, Katsuyoshi Koh, Akira Kikuchi, Takako Komiyama
LEUKEMIA & LYMPHOMA, 55, 5, 1126, 1131, May 2014, [Peer-reviewed]
English, Scientific journal

【血管腫・血管奇形2014:診断からIVR・治療まで】画像診断
野崎 太希, 松迫 正樹, 衛藤 光, 松井 瑞子, 新見 康成, 真部 淳, 草川 功, 鈴木 高祐, 栗原 泰之
臨床画像, 30, 5, 492, 504, (株)メジカルビュー社, May 2014
Japanese

Parents' perception of pediatric cancer centers in Japan
Sachi Sakaguchi, Megumi Oda, Yuichi Shinkoda, Atsushi Manabe
PEDIATRICS INTERNATIONAL, 56, 2, 196, 199, Apr. 2014, [Peer-reviewed]
English, Scientific journal

小児顎下腺腫瘍の2例
森田 有香, 野崎 太希, 槇殿 文香理, 細谷 要介, 長谷川 大輔, 真部 淳, 細谷 亮太, 川野 孝文, 鈴木 高祐, 齋田 幸久
日本小児放射線学会雑誌, 30, 1, 44, 50, (一社)日本小児放射線学会, Mar. 2014
Japanese

Allogeneic stem cell transplantation for patients with acute myeloid leukaemia developing from severe congenital neutropenia
Yasuhiro Ebihara, Kumiko Ishikawa, Shinji Mochizuki, Ryuhei Tanaka, Atsushi Manabe, Tohru Iseki, Taira Maekawa, Kohichiro Tsuji
BRITISH JOURNAL OF HAEMATOLOGY, 164, 3, 459, 461, Feb. 2014, [Peer-reviewed]
English

No impact of high-dose cytarabine and asparaginase as early intensification with intermediate-risk paediatric acute lymphoblastic leukaemia: results of randomized trial TCCSG study L99-15
Motohiro Kato, Katsuyoshi Koh, Atsushi Manabe, Tomohiro Saito, Daisuke Hasegawa, Keiichi Isoyama, Akitoshi Kinoshita, Miho Maeda, Yuri Okimoto, Michiko Kajiwara, Takashi Kaneko, Kanji Sugita, Akira Kikuchi, Masahiro Tsuchida, Akira Ohara
BRITISH JOURNAL OF HAEMATOLOGY, 164, 3, 376, 383, Feb. 2014, [Peer-reviewed]
English, Scientific journal

蛋白漏出性胃腸症で発症したHenoch-Schoenlein紫斑病の一例　　　　　　　　　　　　　　　
孫 楽, 吉本 優里, 小野 林太郎, 長谷川 大輔, 小澤 美和, 真部 淳, 草川 功
日本小児科学会雑誌, 118, 2, 398, 398, (公社)日本小児科学会, Feb. 2014
Japanese

熱性痙攣に対する抗ヒスタミン薬の影響についての検討　　　　　　　　　　　　　　　
辻本 信一, 吉本 優里, 小野 林太郎, 小澤 美和, 真部 淳, 草川 功, 石田 也寸志, 荻原 正明
日本小児科学会雑誌, 118, 2, 230, 230, (公社)日本小児科学会, Feb. 2014
Japanese

Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group
Trudy D. Buitenkamp, Shai Izraeli, Martin Zimmermann, Erik Forestier, Nyla A. Heerema, Marry M. van den Heuvel-Eibrink, Rob Pieters, Carin M. Korbijn, Lewis B. Silverman, Kjeld Schmiegelow, Der-Cheng Liang, Keizo Horibe, Maurizio Arico, Andrea Biondi, Giuseppe Basso, Karin R. Rabin, Martin Schrappe, Gunnar Cario, Georg Mann, Maria Morak, Renate Panzer-Grumayer, Veerle Mondelaers, Tim Lammens, Helene Cave, Batia Stark, Ithamar Ganmore, Anthony V. Moorman, Ajay Vora, Stephen P. Hunger, Ching-Hon Pui, Charles G. Mullighan, Atsushi Manabe, Gabriele Escherich, Jerzy R. Kowalczyk, James A. Whitlock, C. Michel Zwaan
BLOOD, 123, 1, 70, 77, Jan. 2014, [Peer-reviewed]
English, Scientific journal

血液検査所見が正常で骨病変にて発見されたB前駆細胞性急性リンパ性白血病(ALL)の1例　　　　　　　　　　　　　　　
原 朋子, 長谷川 大輔, 小野 林太郎, 居石 崇志, 吉本 優里, 上野 浩生, 細谷 要介, 吉原 宏樹, 真部 淳
日本小児科学会雑誌, 118, 1, 77, 77, (公社)日本小児科学会, Jan. 2014
Japanese

Significance of CD66c expression in childhood acute lymphoblastic leukemia
Nobutaka Kiyokawa, Kazutoshi Iijima, Osamu Tomita, Masashi Miharu, Daisuke Hasegawa, Kenichiro Kobayashi, Hajime Okita, Michiko Kajiwara, Hiroyuki Shimada, Takeshi Inukai, Atsushi Makimoto, Toru Nanmoku, Katsuyoshi Koh, Atsushi Manabe, Akira Kikuchi, Junichiro Fujimoto, Yasuhicie Hayashi, Akira Ohara
LEUKEMIA RESEARCH, 38, 1, 42, 48, Jan. 2014, [Peer-reviewed]
English, Scientific journal

Significance of CD66c expression in childhood acute lymphoblastic leukemia
Nobutaka Kiyokawa, Kazutoshi Iijima, Osamu Tomita, Masashi Miharu, Daisuke Hasegawa, Kenichiro Kobayashi, Hajime Okita, Michiko Kajiwara, Hiroyuki Shimada, Takeshi Inukai, Atsushi Makimoto, Takashi Fukushima, Toru Nanmoku, Katsuyoshi Koh, Atsushi Manabe, Akira Kikuchi, Kanji Sugita, Junichiro Fujimoto, Yasuhide Hayashi, Akira Ohara
Leukemia Research, 38, 1, 42, 48, Jan. 2014, [Peer-reviewed]
English, Scientific journal

Imaging of vascular tumors with an emphasis on ISSVA classification
Taiki Nozaki, Masaki Matsusako, Hidefumi Mimura, Keigo Osuga, Mizuko Matsui, Hikaru Eto, Naoyuki Ohtake, Atsushi Manabe, Isao Kusakawa, Yoshiyuki Tsutsumi, Shunsuke Nosaka, Minobu Kamo, Yukihisa Saida
JAPANESE JOURNAL OF RADIOLOGY, 31, 12, 775, 785, Dec. 2013, [Peer-reviewed]
English, Scientific journal

【小児の痛みについて考える】小児の疼痛の緩和 小児がん性疼痛治療
小澤 美和, 真部 淳
小児科臨床, 66, 12, 2541, 2547, (株)日本小児医事出版社, Dec. 2013
Japanese

Significance Of Minimal Residual Disease Detected By Multi-Color Flow Cytometry In Childhood Acute Myeloid Leukemia With The Intermideate-Risk Cytogenetics and Negative FMS-Like Tyrosine Kinase 3 Internal Tandem Duplication: A Report Of The Tokyo Children's Cancer Study Group
Dai Keino, Akitoshi Kinoshita, Daisuke Tomizawa, Hiroyuki Takahashi, Kohmei Ida, Hidemitsu Kurosawa, Kazutoshi Koike, Setsuo Ota, Noriyuki Iwasaki, Junya Fujimura, Yuki Yuza, Chikako Kiyotani, Shohei Yamamoto, Tomoo Osumi, Takahiro Ueda, Shinji Mochizuki, Keiichi Isoyama, Ryoji Hanada, Akio Tawa, Akira Kikuchi, Atsushi Manabe, Akira Ohara
Blood, 122, 21, 1416, 1416, American Society of Hematology, 15 Nov. 2013
Scientific journal, Abstract

Background

Response to induction chemotherapy is one of the most important predictors of outcome in acute myeloid leukemia (AML) as well as cytogenetics and molecular genetics. Measurement of minimal residual disease (MRD) by flow cytometry is an informative method for assessment of initial treatment response, but the heterogeneity of leukemia-associated antigens and antigen shifts during treatment limit its sensitivity and specificity. We prospectively evaluated the prognostic prevalence of MRD monitoring using multi-color flow cytometry in children with AML treated on the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05 trial.

Patients and methods

From January 2007 to October 2010, 34 children with newly diagnosed de novo AML were enrolled on the AML-MRD study conducted by the Tokyo Children's Cancer Study Group. The median age at the diagnosis was 8 years (1 month- 15 years), and 17 patients were boys and 17 were girls. They were all treated with the JPLSG AML-05 trial. In AML-05, enrolled patients received two induction courses and those achieving a complete remission (CR) were treated according to risk classification at which all the core binding factor-AML cases and good initial response based on morphology after induction 1 were assigned to low risk (LR) group, cases presented with FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD), unfavorable cytogenetics including monosomy7, 5q-,t(16;21), and with poor initial response were assigned to high risk (HR) group, the others were assigned to intermediate risk (IR) group. Allogeneic hematopoietic stem cell transplantation (HSCT) was indicated for the HR patients after the third or later treatment courses. Among the 34 patients enrolled on the AML-MRD study, 8 presented with LR, 22 with IR, and 4 with HR regarding the cytogenetics and FLT3-ITD status. MRD of 63 bone marrow samples were analyzed after induction 1 (BMA-2) and induction 2 (BMA-3) by four-color flow cytometry using 9 AML-associated antigens. A threshold level for MRD-positivity was set at the point of 0.1%.

Results

Sixty-two (98.4%) of 63 bone marrow samples were evaluable for MRD. Thirteen (39.4%) of 33 samples and 8 (27.6%) of 29 showed MRD-positivity at BMA-2 and BMA-3 respectively. Among the patients with MRD-positivity, 12 at BMA-2 and 7 at BMA-3 were diagnosed as achieving CR by morphology. MRD was associated neither specific FAB subtype nor white blood cell count at diagnosis, but all 3 patients with FLT3-ITD showed the MRD-positivity at BMA-2. Although 3-year probability of event free survival (3-yr EFS) at BMA-2 or BMA-3 was similar between patients with and without MRD; 53.8% (n= 13) vs 70.0% (n= 20) (p=0.30) and 50.0% (n= 8)vs 62.0%(n= 21) (p=0.36), respectively, 3-yr EFS of those with MRD at BMA-2 or BMA-3 was significantly worse compared to those without MRD; 33.3% (n= 9) vs 83.3% (n= 12) (p=0.02) and 20.0%(n= 5) vs 76.9% (n= 13) (p=0.04), respectively, in the group of the IR cytogenetics and negative FLT3-ITD. Multivariate analysis indicated that the MRD detected by multi-color flow cytometry was solely associated with worse outcome in this group.

Conclusion

Highly sensitive detection of MRD by multi-color flow cytometry was possible in children with AML. The present study suggests that MRD monitoring may have a prognostic relevance in childhood AML with the IR cytogenetics and negative FLT3-ITD.

Disclosures:

No relevant conflicts of interest to declare.

骨病変が先行して発症した急性リンパ性白血病の4例　　　　　　　　　　　　　　　
原 朋子, 長谷川 大輔, 野崎 太希, 小野 林太郎, 吉本 優里, 上野 浩生, 細谷 要介, 吉原 宏樹, 熊本 忠志, 細谷 亮太, 真部 淳
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 55回・11回・18回, 284, 284, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2013
Japanese

MDSに血球貪食症候群を合併し、移植後自己造血回復状態となるも異常クローンを認めず経過観察している1例　　　　　　　　　　　　　　　
上野 浩生, 石田 悠志, 小野 林太郎, 吉本 優里, 細谷 要介, 吉原 宏樹, 長谷川 大輔, 大島 久美, 熊本 忠史, 森 慎一郎, 細谷 亮太, 真部 淳
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 55回・11回・18回, 328, 328, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2013
Japanese

初期治療反応性が不良で早期再発を来したDown症候群合併急性巨核芽球性白血病(DS-AMKL)例　　　　　　　　　　　　　　　
吉本 優里, 小野 林太郎, 上野 浩生, 細谷 要介, 吉原 宏樹, 長谷川 大輔, 小澤 美和, 熊本 忠史, 森 愼一郎, 澤田 明久, 井上 雅美, 細谷 亮太, 真部 淳
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 55回・11回・18回, 249, 249, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2013
Japanese

Ultra low-dose cytarabine(Ara-C)療法で寛解を維持しているDown症合併急性巨核芽球性白血病(DS-AMKL)の一例　　　　　　　　　　　　　　　
吉本 優里, 吉原 宏樹, 小野 林太郎, 上野 浩生, 細谷 要介, 長谷川 大輔, 熊本 忠史, 小澤 美和, 岩本 彰太郎, 盛武 浩, 細谷 亮太, 真部 淳
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 55回・11回・18回, 249, 249, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2013
Japanese

寛解状態にある小児がん患者の退院後の生活を支えるソーシャルサポートの特徴　　　　　　　　　　　　　　　
武井 優子, 小澤 美和, 盛武 浩, 真部 淳, 鈴木 伸一
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 55回・11回・18回, 310, 310, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2013
Japanese

終末期の子どもをケアする医療者へのグリーフケアの検討　　　　　　　　　　　　　　　
鳥山 祐子, 齊藤 由華, 小川 恵里子, 植松 温子, 清藤 育子, 高嶋 希世子, 西野 理英, 関冨 晶子, 吉原 宏樹, 小澤 美和, 真部 淳, 細谷 亮太
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 55回・11回・18回, 374, 374, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2013
Japanese

ダウン症児の受容過程について理解し合えなかった両親が、白血病で子どもを亡くした後にむかえた夫婦の危機　　　　　　　　　　　　　　　
清藤 育子, 植松 温子, 小川 恵理子, 鳥山 裕子, 上野 浩生, 長谷川 大輔, 細谷 要介, 小澤 美和, 真部 淳, 細谷 亮太
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 55回・11回・18回, 383, 383, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2013
Japanese

A review series begins: How much do we know about intractable disease?
Atsushi Manabe
PEDIATRICS INTERNATIONAL, 55, 5, 541, 541, Oct. 2013, [Peer-reviewed]
English

[Molecular biology in childhood acute lymphoblastic leukemia (ALL)].
Manabe A
[Rinsho ketsueki] The Japanese journal of clinical hematology, 54, 10, 1999, 2005, The Japanese Society of Hematology, Oct. 2013, [Peer-reviewed]
Japanese

Availability of 10 color flow cytometry in childhood leukemia MRD detection
MIHARU Masashi, KIYOKAWA Nobutaka, KOBAYASHI Kenichiro, OKITA Hajime, LIJIMA Kazutoshi, MORI Tetsuya, SAITO Masahiro, FUKUSHIMA Takashi, KO Katsuyoshi, MANABE Atsushi, KIKUCHI Akira, HAYASHI Yasuhide, OHARA Akira
Cytometry Research, 23, 2, 7, 14, Japan Cytometry Society, 25 Sep. 2013
Japanese,

In childhood acute lymphoblastic leukemia (ALL), the clinical significance of minimal residual disease (MRD) has been demonstrated. Polymerase chain reaction assays based on the detection of clonal rearrangement of immunoglobulin and T-cell receptor genes are most established method for MRD analysis. However, the flow cytometric detection of MRD also has advantages in simplicity of the method as well as a low-cost, high-performance. Conventionally, 3 or 4 color analysis employing multiple test tubes of the panel of antibodies is used for the detection of leukemia-associated immunophenotypes, whereas we developed 10 color methods of MRD detection for both BCP-ALL and T-ALL. Our methods are able to take effect easily and exhibit high performance. To put it to practical use, further investigations are now underway.

Overview
MANABE Atsushi
Rinsho Ketsueki, 54, 8, 719, 720, The Japanese Society of Hematology, 30 Aug. 2013
Japanese

[What we can learn from childhood leukemology: focusing on ALL].
Manabe A
[Rinsho ketsueki] The Japanese journal of clinical hematology, 54, 8, 744, 748, The Japanese Society of Hematology, Aug. 2013, [Peer-reviewed]
Japanese

[Retrospective analysis of treatment strategy and prognosis in childhood myelodysplastic syndromes from China and Japan].
Chen XJ, Manabe A, Yang WY, Zhang PH, Wang SC, Guo Y, Liu F, Chang LX, Wei W, Wan Y, Zhu XF
Zhongguo shi yan xue ye xue za zhi, 21, 4, 940, 947, Aug. 2013, [Peer-reviewed]

[Information on pediatric hematology necessary for hematology internists. Overview].
Manabe A
[Rinsho ketsueki] The Japanese journal of clinical hematology, 54, 8, 719, 720, Aug. 2013, [Peer-reviewed]

Incidence and survival rates of hematological malignancies in Japanese children and adolescents (2006-2010): based on registry data from the Japanese Society of Pediatric Hematology
Keizo Horibe, Akiko M. Saito, Tetsuya Takimoto, Masahiro Tsuchida, Atsushi Manabe, Midori Shima, Akira Ohara, Shuki Mizutani
INTERNATIONAL JOURNAL OF HEMATOLOGY, 98, 1, 74, 88, Jul. 2013, [Peer-reviewed]
English, Scientific journal

Temporal Lobe Epilepsy With Hippocampal Sclerosis in Acute Lymphoblastic Leukemia
Emi Kasai-Yoshida, Masaaki Ogihara, Miwa Ozawa, Taiki Nozaki, Michiharu Morino, Atsushi Manabe, Ryota Hosoya
PEDIATRICS, 132, 1, E252, E256, Jul. 2013, [Peer-reviewed]
English, Scientific journal

Li Fraumeni症候群に発症したGlioblastomaの1男児例
上野 浩生, 小野 林太郎, 吉本 優里, 細谷 要介, 吉原 宏樹, 長谷川 大輔, 熊本 忠史, 真部 淳, 細谷 亮太, 野崎 太希, 萩原 英樹, 師田 信人
日本小児血液・がん学会雑誌, 50, 2, 284, 284, (一社)日本小児血液・がん学会, Jul. 2013
Japanese

Aggressive Transformation of Juvenile Myelomonocytic Leukemia Associated with Duplication of Oncogenic KRAS due to Acquired Uniparental Disomy
Motohiro Kato, Naoko Yasui, Masafumi Seki, Hiroshi Kishimoto, Aiko Sato-Otsubo, Daisuke Hasegawa, Nobutaka Kiyokawa, Ryoji Hanada, Seishi Ogawa, Atsushi Manabe, Junko Takita, Katsuyoshi Koh
JOURNAL OF PEDIATRICS, 162, 6, 1285, +, Jun. 2013, [Peer-reviewed]
English, Scientific journal

Magnetic resonance imaging appearance of primary spinal extradural Ewing's sarcoma: Case report and literature review
S. Tsutsumi, Y. Yasumoto, A. Manabe, I. Ogino, H. Arai, M. Ito
Clinical Neuroradiology, 23, 2, 81, 85, Jun. 2013, [Peer-reviewed]
English, International conference proceedings

IDEAL‐IQで鉄含有量の半定量化を試みたヘモクロマトーシスの3例
森田有香, 野崎太希, 小野林太郎, 長谷川大輔, 吉原宏樹, 細谷要介, 真部淳, 齋田幸久
日本小児放射線学会雑誌, 29, 20, 20 May 2013
Japanese

Association between parental preference and head computed tomography in children with minor blunt head trauma.
Yasushi Ishida, Atsushi Manabe, Aya Oizumi, Norio Otani, Michio Hirata, Kevin Urayama, Yukihisa Saida, Isao Kusakawa, Tsuguya Fukui
JAMA pediatrics, 167, 5, 491, 2, May 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal

WiskottAldrich syndrome presenting with a clinical picture mimicking juvenile myelomonocytic leukaemia
Ayami Yoshimi, Yoshiro Kamachi, Kosuke Imai, Nobuhiro Watanabe, Hisaya Nakadate, Takashi Kanazawa, Shuichi Ozono, Ryoji Kobayashi, Misa Yoshida, Chie Kobayashi, Asahito Hama, Hideki Muramatsu, Yoji Sasahara, Marcus Jakob, Tomohiro Morio, Stephan Ehl, Atsushi Manabe, Charlotte Niemeyer, Seiji Kojima
PEDIATRIC BLOOD & CANCER, 60, 5, 836, 841, May 2013, [Peer-reviewed]
English, Scientific journal

Wiskott-Aldrich syndrome presenting with a clinical picture mimicking juvenile myelomonocytic leukaemia
Ayami Yoshimi, Yoshiro Kamachi, Kosuke Imai, Nobuhiro Watanabe, Hisaya Nakadate, Takashi Kanazawa, Shuichi Ozono, Ryoji Kobayashi, Misa Yoshida, Chie Kobayashi, Asahito Hama, Hideki Muramatsu, Yoji Sasahara, Marcus Jakob, Tomohiro Morio, Stephan Ehl, Atsushi Manabe, Charlotte Niemeyer, Seiji Kojima
Pediatric Blood and Cancer, 60, 5, 836, 841, May 2013, [Peer-reviewed]
English, Scientific journal

[Current national and international status of supportive therapy for the coagulopathy associated with L-asparaginase containing regimen for acute lymphoblastic leukemia].
Ogawa C, Manabe A, Ohara A, Ishiguro A
[Rinsho ketsueki] The Japanese journal of clinical hematology, 54, 3, 316, 318, The Japanese Society of Hematology, Mar. 2013, [Peer-reviewed]
Japanese, We investigated supportive therapy against coagulopathy associated with L-asparaginase treatment in patients with acute lymphoblastic leukemia who were enrolled in the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG), Japan Adult Leukemia Study Group (JALSG), and foreign institutes. Fresh frozen plasma (FFP) was administered as a supplement in 46% patients in the JPLSG and 86% in the JALSG. The threshold level of FFP infusion was less than 100 mg/dl plasma fibrinogen in 70% of the JALSG and 20% of the JPLSG, while in another 20% of the JPLSG, FFP was administered when the fibrinogen level was less than 50 mg/dl. The preventive use of antithrombin products (AT) was prescribed in 93% of the JPLSG and 63% of the JALSG: The threshold level of AT supplementation was less than 70% of plasma antithrombin activity, which was similar in both groups. Most foreign institutes do not routinely use FFP or AT.

Resetting the course for Pediatrics International
Atsushi Manabe
PEDIATRICS INTERNATIONAL, 55, 1, 1, 1, Feb. 2013, [Peer-reviewed]
English

小児がん患者に併発したClostridium difficile腸炎の再発のリスク因子の検討　　　　　　　　　　　　　　　
吉原 宏樹, 代田 惇朗, 稲井 郁子, 小野 林太郎, 細谷 要介, 長谷川 大輔, 石田 也寸志, 真部 淳, 細谷 亮太
日本小児科学会雑誌, 117, 2, 345, 345, (公社)日本小児科学会, Feb. 2013
Japanese

小児慢性良性好中球減少症患者24名の臨床経過についての検討　　　　　　　　　　　　　　　
上野 浩生, 小野 林太郎, 細谷 要介, 吉原 宏樹, 長谷川 大輔, 真部 淳, 細谷 亮太
日本小児科学会雑誌, 117, 2, 370, 370, (公社)日本小児科学会, Feb. 2013
Japanese

Characteristics of Illness Perception and Psychosocial Adaptation of Survivors of Childhood Cancer
TAKEI Yuko, OGATA Akiko, OZAWA Miwa, MORITAKE Hiroshi, HIRAI Kei, MANABE Atsushi, SUZUKI Shin-ichi
Japanese journal of behavior therapy, 39, 1, 23, 33, Japanese Association of Behavioral and Cognitive Therapies, 31 Jan. 2013
Japanese, The purpose of the present study was to examine the correlation between perceived illness experiences and psychosocial adaptation in adolescent childhood cancer survivors. The participants, 21 youth (7 boys, 14 girls; average age 15.8 years, SD 2.1) who were cancer patients attending pediatric outpatient clinics, were asked to participate in a semi-structured interview and complete the Pediatric Quality of Life (QOL) Inventory. The results indicated that psychosocial daily difficulties influenced their illness perception. Although the results were not statistically significant, positive perception might correlate positively with QOL, and negative perception or a despairing attitude might correlate negatively with QOL. Future research should investigate those influences in a quantitative study.

[Childhood acute lymphoblastic leukemia (ALL)].
Manabe A, Hasegawa D
[Rinsho ketsueki] The Japanese journal of clinical hematology, 54, 1, 100, 108, Jan. 2013, [Peer-reviewed]

Current evidence for an inherited genetic basis of childhood acute lymphoblastic leukemia
Kevin Y. Urayama, Anand P. Chokkalingam, Atsushi Manabe, Shuki Mizutani
INTERNATIONAL JOURNAL OF HEMATOLOGY, 97, 1, 3, 19, Jan. 2013, [Peer-reviewed]
English, Scientific journal

Clinical and genetic characteristics of congenital sideroblastic anemia: comparison with myelodysplastic syndrome with ring sideroblast (MDS-RS)
Rie Ohba, Kazumichi Furuyama, Kenichi Yoshida, Tohru Fujiwara, Noriko Fukuhara, Yasushi Onishi, Atsushi Manabe, Etsuro Ito, Keiya Ozawa, Seiji Kojima, Seishi Ogawa, Hideo Harigae
ANNALS OF HEMATOLOGY, 92, 1, 1, 9, Jan. 2013, [Peer-reviewed]
English, Scientific journal

致死的な血球貪食症候群を来したUPD-14の1例　　　　　　　　　　　　　　　
米川 聡子, 居石 崇志, 細谷 要介, 吉原 宏樹, 長谷川 大輔, 草川 功, 真部 淳, 野崎 太希, 川野 孝文, 細谷 亮太
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 54回・10回・17回, 324, 324, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2012
Japanese

家族性発がん症候群へのアプローチと問題点 当院での経験より　　　　　　　　　　　　　　　
吉原 宏樹, 熊本 忠史, 細谷 要介, 長谷川 大輔, 野崎 太希, 山中 美智子, 小川 千登世, 真部 淳, 細谷 亮太
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 54回・10回・17回, 334, 334, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2012
Japanese

卵巣奇形腫を母体として発症したstage IV神経芽腫の1例　　　　　　　　　　　　　　　
米川 聡子, 居石 崇志, 細谷 要介, 吉原 宏樹, 長谷川 大輔, 小川 千登世, 真部 淳, 細谷 亮太, 塩田 恭子, 川野 孝文, 野崎 太希, 鈴木 高祐
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 54回・10回・17回, 350, 350, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2012
Japanese

小児急性リンパ性白血病におけるL-アスパラギナーゼの過敏反応に関する後方視的検討　　　　　　　　　　　　　　　
渡辺 静, 長谷川 大輔, 吉原 宏樹, 細谷 要介, 小川 千登世, 後藤 一美, 真部 淳, 細谷 亮太
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 54回・10回・17回, 355, 355, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2012
Japanese

小児慢性良性好中球減少症患者24名の臨床経過についての検討　　　　　　　　　　　　　　　
上野 浩生, 吉本 優里, 細谷 要介, 吉原 宏樹, 長谷川 大輔, 真部 淳, 細谷 亮太
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 54回・10回・17回, 367, 367, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2012
Japanese

小児急性リンパ性白血病の維持療法における副作用発現および投与量へのMRP4遺伝子多型の影響　　　　　　　　　　　　　　　
田中 庸一, 真部 淳, 中舘 尚也, 近藤 健介, 康 勝好, 中村 こずえ, 菊池 陽, 小宮山 貴子
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 54回・10回・17回, 287, 287, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2012
Japanese

初発時に多発する頭蓋内出血を来したPh陽性急性リンパ性白血病の10歳女児の1例　　　　　　　　　　　　　　　
小野 林太郎, 長谷川 大輔, 石田 悠志, 細谷 要介, 吉原 宏樹, 熊本 忠史, 小川 千登世, 真部 淳, 細谷 亮太
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 54回・10回・17回, 320, 320, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2012
Japanese

当院における小児がんの患児への告知に関する過去20年の検討　　　　　　　　　　　　　　　
吉本 優里, 上野 浩生, 吉原 宏樹, 細谷 要介, 長谷川 大輔, 小澤 美和, 石田 也寸志, 真部 淳, 細谷 亮太
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 54回・10回・17回, 267, 267, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2012
Japanese

思春期患者のEnd-of-Lifeケアにおけるチーム医療の課題　　　　　　　　　　　　　　　
小川 恵理子, 植松 温子, 鳥山 祐子, 高嶋 希世子, 齋藤 由華, 清藤 育子, 西野 理英, 長谷川 大輔, 小澤 美和, 真部 淳, 細谷 亮太
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 54回・10回・17回, 307, 307, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2012
Japanese

VDC/ICE療法及び放射線照射を行なった腎悪性ラブドイド腫瘍(MRTK)の一例　　　　　　　　　　　　　　　
辻本 信一, 上野 浩生, 細谷 要介, 吉原 宏樹, 長谷川 大輔, 真部 淳, 細谷 亮太
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 54回・10回・17回, 354, 354, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2012
Japanese

高リスク神経芽腫に対するWT1ペプチドワクチン投与の経験　　　　　　　　　　　　　　　
細谷 要介, 吉原 宏樹, 長谷川 大輔, 西川 英里, 谷ヶ崎 博, 鈴木 涼子, 小林 千恵, 橋井 佳子, 杉山 治夫, 真部 淳, 細谷 亮太
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 54回・10回・17回, 408, 408, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2012
Japanese

WT1ペプチドワクチンによる再発抑制効果を期待した小児悪性骨・軟部腫瘍対象多施設共同臨床試験　　　　　　　　　　　　　　　
橋井 佳子, 坪井 昭博, 尾路 祐介, 中島 博子, 岡 芳弘, 岩城 拓磨, 岩瀬 孝志, 細谷 要介, 真部 淳, 辻 尚子, 湯坐 有希, 杉山 治夫, 大薗 恵一
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 54回・10回・17回, 426, 426, (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2012
Japanese

卵巣奇形腫を母体として発症したStage IV神経芽腫
米川 聡子, 居石 崇志, 細谷 要介, 吉原 宏樹, 長谷川 大輔, 小川 千登世, 真部 淳, 細谷 亮太, 塩田 恭子, 川野 孝文, 野崎 太希, 鈴木 高祐
日本小児血液・がん学会雑誌, 49, 3, 409, 409, (一社)日本小児血液・がん学会, Oct. 2012
Japanese

Outcome of children with refractory anaemia with excess of blast (RAEB) and RAEB in Transformation (RAEB-T) in the Japanese MDS99 study
Akira Kikuchi, Daisuke Hasegawa, Yoshitoshi Ohtsuka, Kazuko Hamamoto, Seiji Kojima, Jun Okamura, Tatsutoshi Nakahata, Atsushi Manabe
BRITISH JOURNAL OF HAEMATOLOGY, 158, 5, 657, 661, Sep. 2012, [Peer-reviewed]
English, Scientific journal

[Molecular mechanism and treatment of juvenile myelomonocytic leukemia (JMML)].
Manabe A
[Rinsho ketsueki] The Japanese journal of clinical hematology, 53, 8, 729, 733, Aug. 2012, [Peer-reviewed]

The Perceived Cancer Experience in Japanese Childhood Cancer Patients : A Qualitative Study
Takei Yuko, Ogata Akiko, Hirai Kei, Ozawa Miwa, Moritake Hiroshi, Manabe Atushi, Suzuki Shin-ichi
Japanese Journal of Psychosomatic Medicine, 52, 7, 638, 645, Japanese Society of Psychosomatic Medicine, 01 Jul. 2012
Japanese, Objectives : Experience of cancer has been linked to post-traumatic stress disorder for childhood cancer survivors. However, it is also an opportunity for personal growth (Jim & Jacobsen., 2008). Evaluating the long-term effects of cancer and its treatment, we have to investigate the impact of cancer in life domains. The purpose of this study was to explore the perception of the cancer experience in Japanese childhood cancer patients. Methods : Subjects were 25 childhood cancer patients attending the pediatric outpatient clinics (8 male and 17 female), median age at survey was 16.8 yrs (13.8-28.8 yrs), median age at diagnosis was 8.0 yrs (2.3-15.0 yrs). Approximately 18 patients had leukemia, 4 suffered from malignant lymphoma and 3 suffered from osteosarcoma, respectively. They were asked to participate in a semi-structured interview regarding the perception of the cancer experience. The data was analyzed with the content analysis, chi-square test and Fisher's exact test. Results: A total of 11 attributes were extracted. The attributes indicated by many of the participants were "having cancer brought my family closer together (n=14)", "I have met various people (n=12)", "can

Physician Preferences and Knowledge Regarding the Care of Childhood Cancer Survivors in Japan: A Mailed Survey of the Japanese Society of Pediatric Oncology
Yasushi Ishida, Miyako Takahashi, Mitsue Maru, Michiko Mori, Tara O. Henderson, Christopher K. Daugherty, Atsushi Manabe
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 42, 6, 513, 521, Jun. 2012, [Peer-reviewed]
English, Scientific journal

Long-term haematological improvement after non-intensive or no chemotherapy in juvenile myelomonocytic leukaemia and poor correlation with adult myelodysplasia spliceosome-related mutations
Kazuyuki Matsuda, Nao Yoshida, Shuhei Miura, Yozo Nakazawa, Kazuo Sakashita, Nobuyuki Hyakuna, Masahiro Saito, Fumiyo Kato, Atsushi Ogawa, Akihiro Watanabe, Manabu Sotomatsu, Chie Kobayashi, Toshiro Ito, Fumihiro Ishida, Atsushi Manabe, Seiji Kojima, Kenichi Koike
BRITISH JOURNAL OF HAEMATOLOGY, 157, 5, 647, 650, Jun. 2012, [Peer-reviewed]
English

The activity of the inosine triphosphate pyrophosphatase affects toxicity of 6-mercaptopurine during maintenance therapy for acute lymphoblastic leukemia in Japanese children
Yoichi Tanaka, Atsushi Manabe, Hisaya Nakadate, Kensuke Kondoh, Kozue Nakamura, Katsuyoshi Koh, Tomoyuki Utano, Akira Kikuchi, Takako Komiyama
LEUKEMIA RESEARCH, 36, 5, 560, 564, May 2012, [Peer-reviewed]
English, Scientific journal

乳癌患者の子どもへの支援に関する医師・看護師の意識調査　　　　　　　　　　　　　　　
小澤 美和, 大野 真司, 石田 也寸志, 武井 優子, 真部 淳
日本乳癌学会総会プログラム抄録集, 20回, 521, 521, (一社)日本乳癌学会, May 2012
Japanese

[Myelodysplastic syndrome in childhood and juvenile myelomonocytic leukemia].
Hasegawa D, Manabe A
Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 2, 681, 686, Apr. 2012, [Peer-reviewed]

[Acute lymphoblastic leukemia (ALL)].
Manabe A
Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 2, 670, 675, Apr. 2012, [Peer-reviewed]

CBL mutation in chronic myelomonocytic leukemia secondary to familial platelet disorder with propensity to develop acute myeloid leukemia (FPD/AML)
Norio Shiba, Daisuke Hasegawa, Myoung-ja Park, Chisato Murata, Aiko Sato-Otsubo, Chitose Ogawa, Atsushi Manabe, Hirokazu Arakawa, Seishi Ogawa, Yasuhide Hayashi
BLOOD, 119, 11, 2612, 2614, Mar. 2012, [Peer-reviewed]
English, Scientific journal

Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: results of the Tokyo Children's Cancer Study Group Study L99-15
Takeshi Inukai, Nobutaka Kiyokawa, Dario Campana, Elaine Coustan-Smith, Akira Kikuchi, Miyuki Kobayashi, Hiroyuki Takahashi, Katsuyoshi Koh, Atsushi Manabe, Masaaki Kumagai, Koichiro Ikuta, Yasuhide Hayashi, Masahiro Tsuchida, Kanji Sugita, Akira Ohara
BRITISH JOURNAL OF HAEMATOLOGY, 156, 3, 358, 365, Feb. 2012, [Peer-reviewed]
English, Scientific journal

TCCSGの小児B前駆細胞型急性リンパ性白血病におけるCRLF2とIKZF1、JAK遺伝子解析　　　　　　　　　　　　　　　
大木 健太郎, 大喜多 肇, 清河 信敬, 朴 明子, 康 勝好, 花田 良二, 真部 淳, 菊地 陽, 小原 明, 林 泰秀
日本小児科学会雑誌, 116, 2, 246, 246, (公社)日本小児科学会, Feb. 2012
Japanese

二相性の経過をとったHHV6脳症4症例の後方視的検討　　　　　　　　　　　　　　　
小野 林太郎, 居石 崇志, 稲井 郁子, 石田 也寸志, 真部 淳, 草川 功, 細谷 亮太
日本小児科学会雑誌, 116, 2, 367, 367, (公社)日本小児科学会, Feb. 2012
Japanese

小児がん患児のきょうだいへの心理的サポート PTSD-RIを用いた縦断研究　　　　　　　　　　　　　　　
東 飛鳥, 小澤 美和, 小林 明雪子, 細谷 要介, 吉原 宏樹, 長谷川 大輔, 小川 千登勢, 石田 也寸志, 真部 淳, 細谷 亮太
日本小児科学会雑誌, 116, 2, 310, 310, (公社)日本小児科学会, Feb. 2012
Japanese

The Utility of Performing the Initial Lumbar Puncture on Day 8 in Remission Induction Therapy for Childhood Acute Lymphoblastic Leukemia: TCCSG L99-15 Study
Daisuke Hasegawa, Atsushi Manabe, Akira Ohara, Akira Kikuchi, Katsuyoshi Koh, Nobutaka Kiyokawa, Takashi Fukushima, Yasushi Ishida, Tomohiro Saito, Ryoji Hanada, Masahiro Tsuchida
PEDIATRIC BLOOD & CANCER, 58, 1, 23, 30, Jan. 2012, [Peer-reviewed]
English, Scientific journal

プライマリケア・マスターコース 小児科診療のすすめ 乳幼児突然死症候群(SIDS)
宮下 文織, 小野 林太郎, 長沖 優子, 石田 也寸志, 真部 淳, 細谷 亮太
日本医事新報, 4578, 46, 49, (株)日本医事新報社, Jan. 2012
Japanese

[Prognosis of 75 patients with juvenile myelomonocytic leukemia: prospective study by MDS committee in the Japanese Society of Pediatric Hematology].
Nao Yoshida, Shinsuke Hirabayashi, Shizuka Watanabe, Yuji Zaike, Masahiro Tsuchida, Ayami Yoshimi, Atsuko Masunaga, Yoshitoshi Otsuka, Masafumi Ito, Seiji Kojima, Tatsutoshi Nakahata, Atsushi Manabe
[Rinsho ketsueki] The Japanese journal of clinical hematology, 52, 12, 1853, 8, Dec. 2011, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, Juvenile myelomonocytic leukemia (JMML) is a myelodysplastic/myeloproliferative disorder of young children. Because the disease is rare and the diagnosis is difficult, a prospective registration of patients suspected of having JMML with a pathological central review have been conducted by the MDS Committee of the Japanese Society of Pediatric Hematology. Between 1999 and 2006, 75 children with JMML were enrolled and diagnosed through this system. Median age at diagnosis was 20 months (1∼85 months). Cytogenetic abnormalities were detected in 21 patients, including 11 with monosomy 7. The 5-year overall survival (OS) was 60%. Regarding the treatment, 61 of the 75 patients received stem cell transplantation (SCT). Conditioning regimen varied widely, and the source of grafts was bone marrow for 43 patients, peripheral blood for 5, and cord blood for 13. The 5-year OS after SCT was 61%. Notably, patients who received cord blood transplantation had inferior survival than those who received grafts from other sources (38 vs. 68%; P=0.03). Given better recognition of the disease, a multi-center protocol study on SCT, JMML11, is now being planned by the Japanese Pediatric Leukemia/Lymphoma Study Group.

急性リンパ性白血病の維持療法における6-メルカプトプリン関連副作用発現へのTPMT、ITPA、MTHFR遺伝子型の影響　　　　　　　　　　　　　　　
田中 庸一, 真部 淳, 中舘 尚也, 近藤 健介, 中村 こずえ, 康 勝好, 菊地 陽, 歌野 智之, 小宮山 貴子
小児がん, 48, プログラム・総会号, 248, 248, (NPO)日本小児がん学会, Nov. 2011
Japanese

高2倍体(hyperdiploid)小児急性リンパ性白血病における増加染色体と予後との関連　　　　　　　　　　　　　　　
加藤 元博, 高橋 浩之, 清河 信敬, 福島 敬, 康 勝好, 真部 淳, 土田 昌宏, 小原 明, 東京小児がん研究グループ(TCCSG)
小児がん, 48, プログラム・総会号, 248, 248, (NPO)日本小児がん学会, Nov. 2011
Japanese

TCCSG-L0416臨床試験にみる完全寛解の定義が寛解割合に及ぼす影響　　　　　　　　　　　　　　　
牧本 敦, 小原 明, 花田 良二, 角南 勝介, 金子 隆, 熊谷 昌明, 真部 淳, 福島 敬, 磯山 恵一, 康 勝好, 井田 孔明, 前田 美穂, 黒澤 秀光, 後藤 裕明, 松井 敦, 菊地 陽, 土田 昌宏, 東京小児がん研究グループ(TCCSG)
小児がん, 48, プログラム・総会号, 249, 249, (NPO)日本小児がん学会, Nov. 2011
Japanese

小児急性リンパ性白血病高危険群に対するBFM95-HR強化療法 TCCSG ALL L99-1502研究　　　　　　　　　　　　　　　
康 勝好, 小原 明, 小川 千登世, 加藤 元博, 清河 信敬, 福島 敬, 嶋田 博之, 高橋 浩之, 梶原 道子, 菊地 陽, 真部 淳, 熊谷 昌明, 花田 良二, 林 泰秀, 土田 昌宏, 東京小児がん研究グループ(TCCSG)
小児がん, 48, プログラム・総会号, 250, 250, (NPO)日本小児がん学会, Nov. 2011
Japanese

小児ALL関連キメラ遺伝子発現量の末梢血中推移と既知リスク因子との関連について　　　　　　　　　　　　　　　
福島 敬, 南木 融, 清河 信敬, 小林 千恵, 福島 紘子, Shaza Mahmoud, 康 勝好, 菊地 陽, 真部 淳, 熊谷 昌明, 土田 昌宏, 林 泰秀, 小原 明, 東京小児がん研究グループ(TCCSG)
小児がん, 48, プログラム・総会号, 250, 250, (NPO)日本小児がん学会, Nov. 2011
Japanese

小児急性リンパ性白血病(ALL)症例における寛解導入不能例の検討 東京小児がん研究グループ(TCCSG)からの報告　　　　　　　　　　　　　　　
細谷 要介, 望月 慎史, 加藤 啓輔, 長谷川 大輔, 清河 信敬, 福島 敬, 康 勝好, 真部 淳, 土田 昌宏, 小原 明, 東京小児がん研究グループ(TCCSG)
小児がん, 48, プログラム・総会号, 313, 313, (NPO)日本小児がん学会, Nov. 2011
Japanese

小児急性リンパ性白血病(ALL)における低強度寛解導入療法に対する反応性 TCCSG L99-15研究より　　　　　　　　　　　　　　　
長谷川 大輔, 真部 淳, 小原 明, 菊地 陽, 康 勝好, 清河 信敬, 福島 敬, 石田 也寸志, 斎藤 友博, 花田 良二, 土田 昌宏, 東京小児がん研究グループ
小児がん, 48, プログラム・総会号, 314, 314, (NPO)日本小児がん学会, Nov. 2011
Japanese

対照的な経過をとったGATA-1変異陽性の非ダウン症AMKLの2症例　　　　　　　　　　　　　　　
小野 林太郎, 馬場 徳朗, 齋藤 怜, 米川 聡子, 吉原 宏樹, 神谷 尚宏, 長谷川 大輔, 小川 千登世, 真部 淳, 細谷 亮太
小児がん, 48, プログラム・総会号, 321, 321, (NPO)日本小児がん学会, Nov. 2011
Japanese

小児がん患者が退院後に抱える心理社会的問題に関するパンフレット作成の試み　　　　　　　　　　　　　　　
武井 優子, 小澤 美和, 樋口 明子, 片山 麻子, 斎藤 秀子, 横川 めぐみ, 真部 淳, 尾形 明子, 鈴木 伸一
小児がん, 48, プログラム・総会号, 245, 245, (NPO)日本小児がん学会, Nov. 2011
Japanese

小児がん経験者の晩期合併症の予測は可能か 聖路加国際病院小児科の経験　　　　　　　　　　　　　　　
石田 也寸志, 渡辺 静, 小澤 美和, 米川 聡子, 小川 千登世, 長谷川 大輔, 細谷 要介, 吉原 宏樹, 真部 淳, 森本 克, 西村 昂三, 細谷 亮太
小児がん, 48, プログラム・総会号, 252, 252, (NPO)日本小児がん学会, Nov. 2011
Japanese

小児がん患者に対する妊孕性温存の現状についての検討　　　　　　　　　　　　　　　
米川 聡子, 小川 千登世, 小澤 美和, 齋藤 怜, 細谷 要介, 吉原 宏樹, 長谷川 大輔, 塩田 恭子, 石田 也寸志, 真部 淳, 細谷 亮太
小児がん, 48, プログラム・総会号, 253, 253, (NPO)日本小児がん学会, Nov. 2011
Japanese

高機能広汎性発達障害を有する子どもの、小児がん入院治療への心理的サポート　　　　　　　　　　　　　　　
阿佐美 百合子, 小澤 美和, 小林 明雪子, 吉原 広樹, 長谷川 大輔, 小川 千登世, 真部 淳, 関富 晶子, 西野 理英, 細谷 亮太
小児がん, 48, プログラム・総会号, 353, 353, (NPO)日本小児がん学会, Nov. 2011
Japanese

WT1ワクチンを用いて寛解を保っている横紋筋肉腫の2例　　　　　　　　　　　　　　　
吉原 宏樹, 細谷 要介, 神谷 尚宏, 長谷川 大輔, 小川 千登世, 澤田 明久, 井上 雅美, 橋井 佳子, 杉山 治夫, 真部 淳, 細谷 亮太
小児がん, 48, プログラム・総会号, 303, 303, (NPO)日本小児がん学会, Nov. 2011
Japanese

Clinical Characteristics and Treatment Outcome of Refractory Cytopenia of Childhood (RCC): A Prospective Registration Through the Japanese Society of Pediatric Hematology
Daisuke Hasegawa, Xiaojuan Chen, Shinsuke Hirabayashi, Yasushi Ishida, Shizuka Watanabe, Yuji Zaike, Masahiro Tsuchida, Atsuko Masunaga, Ayami Yoshimi, Asahito Hama, Seiji Kojima, Masafumi Ito, Tatsutoshi Nakahata, Atsushi Manabe
BLOOD, 118, 21, 1199, 1199, Nov. 2011, [Peer-reviewed]
English

Intellectual development after treatment in children with acute leukemia and brain tumor
Shizuka Watanabe, Yuriko Azami, Miwa Ozawa, Takahiro Kamiya, Daisuke Hasegawa, Chitose Ogawa, Yasushi Ishida, Ryota Hosoya, Junko Kizu, Atsushi Manabe
PEDIATRICS INTERNATIONAL, 53, 5, 694, 700, Oct. 2011, [Peer-reviewed]
English, Scientific journal

MLL関連キメラが検出されないCD10陰性ALLのマーカーと発現遺伝子の特徴(Molecular characteristics and gene expression profiles of CD10-negative B-cell precursor ALL without MLL-rearrangements)　　　　　　　　　　　　　　　
清河 信敬, 飯島 一智, 加藤 元博, 福島 敬, 康 勝好, 真部 淳, 菊地 陽, 熊谷 昌明, 藤本 純一郎, 林 泰秀, 小原 明
日本癌学会総会記事, 70回, 201, 201, (一社)日本癌学会, Sep. 2011
English

[Bone marrow findings of childhood aplastic anemia: analyses of 140 cases by central reviewers].
Hama A, Yoshimi A, Sakaguchi H, Doisaki S, Muramatsu H, Shimada A, Takahashi Y, Nozawa K, Ito M, Tsuchida M, Manabe A, Ohara A, Kojima S
[Rinsho ketsueki] The Japanese journal of clinical hematology, 52, 8, 653, 658, Aug. 2011, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, The revised WHO classification proposed the term "refractory cytopenia of childhood (RCC)" for children with myelodysplastic syndrome (MDS) with a low blast count. The differential diagnosis between RCC and aplastic anemia (AA) is challenging, especially when bone marrow is hypoplastic and there is no detectable chromosomal abnormality. To reveal the difference between AA and RCC with respect to the clinical and biological features, we retrospectively reviewed the bone marrow smears of 140 patients registered for childhood AA-97 study, which were classified into three groups as follows; the AA group was defined as having no morphologically dysplastic changes; the AA-RCC borderline group was defined as having <10% dysplastic changes in the erythroid lineage only; and the RCC group was defined as having dysplastic changes in more than two cell lineages or >10% in a single cell lineage. The patients were classified into the AA group (n=96, 69%), AA-RCC borderline group (n=20, 14%) and RCC group (n=24, 17%). Most of the patients in the AA group were classified as having very severe disease, whereas most of the patients in the RCC group were classified as non-severe disease. Only 2 patients in the AA group developed acute myeloid leukemia. The response rate to immunosuppressive therapy did not differ among the 3 groups. To demonstrate whether the two diseases are truly different entities, it is necessary to compare molecular backgrounds between the AA and RCC groups.

がんを持つ親の子どもへのサポートグループに関する研究　　　　　　　　　　　　　　　
小林 真理子, 大沢 かおり, 小澤 美和, 石田 也寸志, 真部 淳
日本緩和医療学会学術大会プログラム・抄録集, 16回, 424, 424, (NPO)日本緩和医療学会, Jun. 2011
Japanese

がんになった患者の子どもへの病気説明に関する実態調査(その3) 説明を受けた子どもの反応(アンケートからの質的分析)　　　　　　　　　　　　　　　
井上 絵未, 大沢 かおり, 小林 真理子, 村瀬 有紀子, 茶園 美香, 井上 実穂, 衛藤 美穂, 三浦 絵莉子, 小澤 美和, 石田 也寸志, 真部 淳
日本緩和医療学会学術大会プログラム・抄録集, 16回, 487, 487, (NPO)日本緩和医療学会, Jun. 2011
Japanese

がんになった患者の子どもへの病気説明に関する実態調査(その1) 患者へのアンケート・量的分析　　　　　　　　　　　　　　　
大沢 かおり, 井上 実穂, 小林 真理子, 石田 也寸志, 小澤 美和, 真部 淳
日本緩和医療学会学術大会プログラム・抄録集, 16回, 488, 488, (NPO)日本緩和医療学会, Jun. 2011
Japanese

がんになった患者の子どもへの病気説明に関する実態調査(その2) がん患者が子供に病気を説明する背景　　　　　　　　　　　　　　　
村瀬 有紀子, 井上 実穂, 茶園 美香, 大沢 かおり, 井上 絵未, 衛藤 美穂, 小林 真理子, 三浦 絵莉子, 小澤 美和, 石田 也寸志, 真部 淳
日本緩和医療学会学術大会プログラム・抄録集, 16回, 488, 488, (NPO)日本緩和医療学会, Jun. 2011
Japanese

肝芽腫を合併したUPD‐14の2例
野崎太希, 河野達夫, 清水光政, 草川功, 平田倫生, 槇殿文香理, 真部淳, 平林健, 細谷亮太, 齋田幸久
日本小児放射線学会雑誌, 27, 31, 20 May 2011
Japanese

Low dose cytarabine therapy for transient abnormal myelopoiesis (TAM)
NAKAGAWA Machiko, KUSAKAWA Isao, HIRATA Michio, SAITO Rei, KASAI Emi, HASEGAWA Daisuke, MANABE Atsushi, HOSOYA Ryota
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine, 47, 1, 161, 164, (一社)日本周産期・新生児医学会, 01 May 2011
Japanese

Validation of the Japanese version of the Pediatric Quality of Life Inventory (PedsQL) Cancer Module
Naoko Tsuji, Naoko Kakee, Yasushi Ishida, Keiko Asami, Ken Tabuchi, Hisaya Nakadate, Tsuyako Iwai, Miho Maeda, Jun Okamura, Takuro Kazama, Yoko Terao, Wataru Ohyama, Yuki Yuza, Takashi Kaneko, Atsushi Manabe, Kyoko Kobayashi, Kiyoko Kamibeppu, Eisuke Matsushima
HEALTH AND QUALITY OF LIFE OUTCOMES, 9, 22, Apr. 2011, [Peer-reviewed]
English, Scientific journal

10カラーフローサイトメトリー解析による小児白血病のマーカー診断　　　　　　　　　　　　　　　
清河 信敬, 山田 浩之, 康 勝好, 福島 敬, 真部 淳, 菊地 陽, 熊谷 昌明, 小原 明, 林 泰秀, 土田 昌宏
日本小児科学会雑誌, 115, 2, 328, 328, (公社)日本小児科学会, Feb. 2011
Japanese

Early T-cell precursor ALL同定のための汎用抗原を用いたスコアリング・システム　　　　　　　　　　　　　　　
犬飼 岳史, 清河 信敬, 高橋 浩之, 康 勝好, 真部 淳, 熊谷 昌明, 小原 明, Dario Campana, 杉田 完爾
小児がん, 47, プログラム・総会号, 282, 282, (NPO)日本小児がん学会, Dec. 2010
Japanese

小児急性リンパ性白血病中間危険群に対する早期強化療法としての大量cytarabine療法の意義 TCCSG L99-15研究　　　　　　　　　　　　　　　
康 勝好, 小原 明, 小川 千登世, 加藤 元博, 清河 信敬, 福島 敬, 嶋田 博之, 高橋 浩之, 梶原 道子, 菊地 陽, 真部 淳, 熊谷 昌明, 生田 孝一郎, 花田 良二, 林 泰秀, 土田 昌宏
小児がん, 47, プログラム・総会号, 285, 285, (NPO)日本小児がん学会, Dec. 2010
Japanese

東京小児がん研究グループ急性リンパ性白血病中央診断におけるEarly T-cell precursor ALLのマーカーの特徴　　　　　　　　　　　　　　　
清河 信敬, 犬飼 岳史, 高橋 浩之, 康 勝好, 杉田 完爾, 真部 淳, 菊地 陽, 熊谷 昌明, 小原 明, 林 泰秀, 土田 昌宏
小児がん, 47, プログラム・総会号, 396, 396, (NPO)日本小児がん学会, Dec. 2010
Japanese

東京小児がん研究グループ(TCCSG)ALL L07-1602の寛解導入療法におけるL-アスパラギナーゼの有害事象　　　　　　　　　　　　　　　
小川 千登世, 太田 節雄, 熊谷 昌明, 牧本 敦, 清河 信敬, 福島 敬, 康 勝好, 真部 淳, 花田 良二, 小原 明, 土田 昌宏
小児がん, 47, プログラム・総会号, 397, 397, (NPO)日本小児がん学会, Dec. 2010
Japanese

MLL関連キメラ遺伝子陽性小児急性白血病におけるMCSP抗原発現　　　　　　　　　　　　　　　
山田 浩之, 清河 信敬, 橋本 亙, 恩田 恵子, 飯島 一智, 福島 敬, 康 勝好, 真部 淳, 菊地 陽, 熊谷 昌明, 小原 明
小児がん, 47, プログラム・総会号, 427, 427, (NPO)日本小児がん学会, Dec. 2010
Japanese

急性骨髄性白血病に対して化学療法施行中にα-Streptoccusによる髄膜炎、感染性心内膜炎を呈した1例　　　　　　　　　　　　　　　
小野 林太郎, 居石 崇志, 森山 貴也, 米川 聡子, 山本 剛士, 神谷 尚宏, 小川 千登世, 真部 淳, 野崎 太希, 篠田 正樹, 細谷 亮太
小児がん, 47, プログラム・総会号, 419, 419, (NPO)日本小児がん学会, Dec. 2010
Japanese

小児病棟の入院生活に対する悪性腫瘍児および家族の意識調査 付き添い家族の生活について考える　　　　　　　　　　　　　　　
吉川 久美子, 関冨 晶子, 永瀬 恭子, 天野 こころ, 平田 美佳, 石井 里奈, 大野 尚子, 神谷 尚宏, 長谷川 大輔, 真部 淳, 石田 也寸志, 細谷 亮太
小児がん, 47, プログラム・総会号, 273, 273, (NPO)日本小児がん学会, Dec. 2010
Japanese

小児病棟での生活に対する悪性腫瘍患児およびに家族の意識調査 携帯電話・ポータブルゲームを考える　　　　　　　　　　　　　　　
芹澤 裕子, 天野 こころ, 前田 邦枝, 永瀬 恭子, 関冨 晶子, 平田 美佳, 吉川 久美子, 大野 尚子, 石井 里奈, 長谷川 大輔, 神谷 尚宏, 石田 也寸志, 真部 淳, 細谷 亮太
小児がん, 47, プログラム・総会号, 295, 295, (NPO)日本小児がん学会, Dec. 2010
Japanese

小児がん患者における知的発達のフォローアップ(第2報)　　　　　　　　　　　　　　　
渡辺 静, 阿佐美 百合子, 神谷 尚宏, 長谷川 大輔, 小川 千登世, 小澤 美和, 石田 也寸志, 木津 純子, 後藤 一美, 真部 淳, 細谷 亮太
小児がん, 47, プログラム・総会号, 253, 253, (NPO)日本小児がん学会, Dec. 2010
Japanese

骨髄移植のドナー候補となったきょうだいの心理的現状に関する検討　　　　　　　　　　　　　　　
小林 明雪子, 小澤 美和, 阿佐美 百合子, 東 飛鳥, 神谷 尚宏, 小川 千登世, 石田 也寸志, 真部 淳, 細谷 亮太
小児がん, 47, プログラム・総会号, 385, 385, (NPO)日本小児がん学会, Dec. 2010
Japanese

急性リンパ性白血病患児の同胞への心理的援助 弟を亡くした9歳女子の事例から　　　　　　　　　　　　　　　
阿佐美 百合子, 小澤 美和, 小林 明雪子, 長谷川 大輔, 小川 千登世, 真部 淳, 大野 尚子, 吉川 久美子, 細谷 亮太
小児がん, 47, プログラム・総会号, 386, 386, (NPO)日本小児がん学会, Dec. 2010
Japanese

小児がん患者における病気のとらえ方と退院後の困難の関連性の検討
武井 優子, 尾形 明子, 小澤 美和, 盛武 浩, 真部 淳, 平井 啓, 鈴木 伸一
日本行動療法学会大会発表論文集, 36回, 164, 165, (一社)日本認知・行動療法学会, Dec. 2010
Japanese

Clinical Outcome of Children With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Treated Between 1995 and 2005
Maurizio Arico, Martin Schrappe, Stephen P. Hunger, William L. Carroll, Valentino Conter, Stefania Galimberti, Atsushi Manabe, Vaskar Saha, Andre Baruchel, Kim Vettenranta, Keizo Horibe, Yves Benoit, Rob Pieters, Gabriele Escherich, Lewis B. Silverman, Ching-Hon Pui, Maria Grazia Valsecchi
JOURNAL OF CLINICAL ONCOLOGY, 28, 31, 4755, 4761, Nov. 2010, [Peer-reviewed]
English, Scientific journal

[Recent progress in acute lymphoblastic leukemia in childhood].
Manabe A
[Rinsho ketsueki] The Japanese journal of clinical hematology, 51, 10, 1558, 1563, The Japanese Society of Hematology, Oct. 2010, [Peer-reviewed]
Japanese

Bullous exudative retinal detachment due to infiltration of leukemic cells in a child with acute lymphoblastic leukemia
Kenichi Yoshida, Daisuke Hasegawa, Ayako Takusagawa, Itaru Kato, Chitose Ogawa, Nariaki Echizen, Kishiko Ohkoshi, Tatsuo Yamaguchi, Ryota Hosoya, Atsushi Manabe
INTERNATIONAL JOURNAL OF HEMATOLOGY, 92, 3, 535, 537, Oct. 2010, [Peer-reviewed]
English, Scientific journal

Congenital dyserythropoietic anemia
Takahiro Kamiya, Atsushi Manabe
INTERNATIONAL JOURNAL OF HEMATOLOGY, 92, 3, 432, 438, Oct. 2010, [Peer-reviewed]
English, Scientific journal

小児白血病のマーカー中央診断に対する10カラーフローサイトメトリー解析の有用性　　　　　　　　　　　　　　　
清河 信敬, 恩田 恵子, 橋本 亙, 長谷川 大輔, 飯島 一智, 福島 敬, 齋藤 正博, 藤本 純一郎, 康 勝好, 真部 淳, 菊地 陽, 熊谷 昌明, 小原 明, 林 泰秀, 土田 昌宏
臨床血液, 51, 9, 1153, 1153, (一社)日本血液学会-東京事務局, Sep. 2010
Japanese

急性リンパ節白血病(ALL)治療後に海馬硬化を伴う難治性側頭葉てんかんを発症した女児例　　　　　　　　　　　　　　　
笠井 恵美, 荻原 正明, 小澤 美和, 真部 淳, 草川 功, 野崎 太希, 森本 克, 細谷 亮太
てんかん研究, 28, 2, 300, 300, (一社)日本てんかん学会, Sep. 2010
Japanese

[Molecular biology of juvenile myelomonocytic leukemia (JMML)].
Manabe A
[Rinsho ketsueki] The Japanese journal of clinical hematology, 51, 7, 526, 531, Jul. 2010, [Peer-reviewed]

Spectrum of molecular defects in juvenile myelomonocytic leukaemia includes ASXL1 mutations
Yuka Sugimoto, Hideki Muramatsu, Hideki Makishima, Courtney Prince, Anna M. Jankowska, Nao Yoshida, Yinyan Xu, Nobuhiro Nishio, Asahito Hama, Hiroshi Yagasaki, Yoshiyuki Takahashi, Koji Kato, Atsushi Manabe, Seiji Kojima, Jaroslaw P. Maciejewski
BRITISH JOURNAL OF HAEMATOLOGY, 150, 1, 83, 87, Jul. 2010, [Peer-reviewed]
English, Scientific journal

5カラーおよび10カラーによる小児白血病のマーカー中央診断　　　　　　　　　　　　　　　
清河 信敬, 恩田 恵子, 橋本 亙, 山田 浩之, 高野 邦彦, 飯島 一智, 福島 敬, 藤本 純一郎, 康 勝好, 真部 淳, 菊地 陽, 熊谷 昌明, 小原 明, 林 泰秀, 土田 昌宏
Cytometry Research, 20, Suppl., 65, 65, (一社)日本サイトメトリー学会, Jun. 2010
Japanese

小児白血病におけるCD244の発現　　　　　　　　　　　　　　　
山田 浩之, 清河 信敬, 恩田 恵子, 橋本 亙, 飯島 一智, 福島 敬, 斎藤 正博, 藤本 純一郎, 康 勝好, 真部 淳, 菊地 陽, 熊谷 昌明, 小原 明, 林 泰秀, 土田 昌宏
Cytometry Research, 20, Suppl., 65, 65, (一社)日本サイトメトリー学会, Jun. 2010
Japanese

がんを持つ親の子どもへの支援に関する活動報告　　　　　　　　　　　　　　　
大沢 かおり, 藤井 あけみ, 村瀬 有紀子, 伊藤 ゆかり, 井上 絵未, 中島 美鈴, 村田 和恵, 小林 真理子, 小澤 美和, 石田 也寸志, 真部 淳
日本緩和医療学会学術大会プログラム・抄録集, 15回, 212, 212, (NPO)日本緩和医療学会, Jun. 2010
Japanese

がんを持つ親の子どもへの介入に関する実態調査 医療関係者へのアンケート分析(その1) 量的分析　　　　　　　　　　　　　　　
小林 真理子, 石田 也寸志, 茶園 美香, 小澤 美和, 井上 実穂, 大沢 かおり, 村田 和恵, 真部 淳
日本緩和医療学会学術大会プログラム・抄録集, 15回, 214, 214, (NPO)日本緩和医療学会, Jun. 2010
Japanese

がんを持つ親の子どもへの介入に関する実態調査 医療関係者へのアンケート分析(その2) 量的分析　　　　　　　　　　　　　　　
衛藤 美穂, 小澤 美和, 井上 実穂, 小林 真理子, 西野 なお子, 茶園 美香, 大沢 かおり, 石田 也寸志, 真部 淳
日本緩和医療学会学術大会プログラム・抄録集, 15回, 214, 214, (NPO)日本緩和医療学会, Jun. 2010
Japanese

乳がん患者とその子どもへのサポートを考える CLS介入事例　　　　　　　　　　　　　　　
衛藤 美穂, 伊藤 ゆかり, 小澤 美和, 中島 美鈴, 小林 真理子, 真部 淳
日本乳癌学会総会プログラム抄録集, 18回, 655, 655, (一社)日本乳癌学会, May 2010
Japanese

乳がん患者とその子どもへのサポートを考える 親子で乳がんを考える絵本の作成　　　　　　　　　　　　　　　
中島 美鈴, 小澤 美和, 伊藤 ゆかり, 衛藤 美穂, 小林 真理子, 真部 淳
日本乳癌学会総会プログラム抄録集, 18回, 656, 656, (一社)日本乳癌学会, May 2010
Japanese

急速に呼吸障害が進行した小児のパンデミック(H1N1)2009による急性肺炎の2例　　　　　　　　　　　　　　　
神谷 尚宏, 森山 貴也, 中島 健太郎, 佐藤 真洋, 山本 剛士, 斎藤 怜, 笠井 恵美, 吉田 健一, 中川 真智子, 長谷川 大輔, 小松 なぎさ, 稲井 郁子, 平田 倫生, 小川 千登世, 小澤 美和, 真部 淳, 草川 功, 細谷 亮太, 片山 正夫
日本小児科学会雑誌, 114, 4, 746, 746, (公社)日本小児科学会, Apr. 2010
Japanese

Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia
Hideki Muramatsu, Hideki Makishima, Anna M. Jankowska, Heather Cazzolli, Christine O'Keefe, Nao Yoshida, Yinyan Xu, Nobuhiro Nishio, Asahito Hama, Hiroshi Yagasaki, Yoshiyuki Takahashi, Koji Kato, Atsushi Manabe, Seiji Kojima, Jaroslaw P. Maciejewski
BLOOD, 115, 10, 1969, 1975, Mar. 2010, [Peer-reviewed]
English, Scientific journal

当院における小児のインフルエンザA(H1N1)pdm感染症の受診動向および重症例のまとめ　　　　　　　　　　　　　　　
神谷 尚宏, 中島 健太郎, 笠井 恵美, 中川 真智子, 長谷川 大輔, 稲井 郁子, 小澤 美和, 真部 淳, 草川 功, 細谷 亮太
日本小児科学会雑誌, 114, 2, 215, 215, (公社)日本小児科学会, Feb. 2010
Japanese

Long-term results of Tokyo Children's Cancer Study Group trials for childhood acute lymphoblastic leukemia, 1984-1999
M. Tsuchida, A. Ohara, A. Manabe, M. Kumagai, H. Shimada, A. Kikuchi, T. Mori, M. Saito, M. Akiyama, T. Fukushima, K. Koike, M. Shiobara, C. Ogawa, T. Kanazawa, Y. Noguchi, S. Oota, Y. Okimoto, H. Yabe, M. Kajiwara, D. Tomizawa, K. Ko, K. Sugita, T. Kaneko, M. Maeda, T. Inukai, H. Goto, H. Takahashi, K. Isoyama, Y. Hayashi, R. Hosoya, R. Hanada
LEUKEMIA, 24, 2, 383, 396, Feb. 2010, [Peer-reviewed]
English, Scientific journal

小児がん患者が退院後に抱える心理社会的問題に関する研究の現状と課題　　　　　　　　　　　　　　　
武井優子, 尾形明子, 小澤美和, 真部淳, 鈴木伸一
小児がん, 47, 1, 84, 90, 2010, [Peer-reviewed]
Japanese, Scientific journal

Cytomegalovirus Infection Mimicking Juvenile Myelomonocytic Leukemia Showing Hypersensitivity to Granulocyte-Macrophage Colony Stimulating Factor
Hiroshi Moritake, Toshio Ikeda, Atsushi Manabe, Sachiyo Kamimura, Hiroyuki Nunoi
PEDIATRIC BLOOD & CANCER, 53, 7, 1324, 1326, Dec. 2009, [Peer-reviewed]
English, Scientific journal

Treatment of Children With Refractory Anemia: The Japanese Childhood MDS Study Group Trial (MDS99)
Daisuke Hasegawa, Atsushi Manabe, Hiroshi Yagasaki, Yoshitoshi Ohtsuka, Masami Inoue, Akira Kikuchi, Akira Ohara, Masahiro Tsuchida, Seiji Kojima, Tatsutoshi Nakahata
PEDIATRIC BLOOD & CANCER, 53, 6, 1011, 1015, Dec. 2009, [Peer-reviewed]
English, Scientific journal

泌尿生殖器領域の横紋筋肉腫に対する外科の役割について　　　　　　　　　　　　　　　
中村 晃子, 平林 健, 松藤 凡, 小川 千登世, 真部 淳, 細谷 亮太
小児がん, 46, プログラム・総会号, 218, 218, (NPO)日本小児がん学会, Nov. 2009
Japanese

脾臓摘出術後に同種臍帯血移植を行なった再発RBM15-MKL1陽性急性巨核芽球性白血病の一例　　　　　　　　　　　　　　　
長谷川 大輔, 神谷 尚宏, 吉田 健一, 中島 健太郎, 有馬 慶太郎, 平林 真介, 中村 晃子, 平林 健, 松藤 凡, 小川 高史, 藤原 美恵子, 鈴木 高祐, 小川 千登世, 真部 淳, 細谷 亮太
小児がん, 46, プログラム・総会号, 407, 407, (NPO)日本小児がん学会, Nov. 2009
Japanese

東京小児がん研究グループ急性リンパ性白血病第16次治療研究におけるマーカー中央診断　　　　　　　　　　　　　　　
清河 信敬, 恩田 恵子, 平林 真介, 飯島 一智, 福島 敬, 齋藤 正博, 藤本 純一郎, 真部 淳, 康 勝好, 熊谷 昌明, 小原 明, 林 泰秀, 花田 良二, 土田 昌宏
小児がん, 46, プログラム・総会号, 226, 226, (NPO)日本小児がん学会, Nov. 2009
Japanese

日本人小児ALLにおけるBFM95 protocol Mに基づいた5g/m2 MTX投与の安全性に関する検討　　　　　　　　　　　　　　　
大隅 朋生, 小川 千登世, 康 勝好, 嶋 晴子, 三春 晶嗣, 大久保 淳, 真部 淳, 嶋田 博之
小児がん, 46, プログラム・総会号, 229, 229, (NPO)日本小児がん学会, Nov. 2009
Japanese

治療中再発に対してimatinib併用Hyper-CVAD療法による第2寛解導入後にHLA一致同胞間移植を行ったPh+ALLの2例　　　　　　　　　　　　　　　
有馬 慶太郎, 長谷川 大輔, 中島 健太郎, 吉田 健一, 平林 真介, 神谷 尚宏, 小川 千登世, 小澤 美和, 真部 淳, 細谷 亮太
小児がん, 46, プログラム・総会号, 231, 231, (NPO)日本小児がん学会, Nov. 2009
Japanese

Parvovirus B19感染によりaplastic crisisを来たしたcongenital dyserythropoietic anemia type 2の1例　　　　　　　　　　　　　　　
笠井 恵美, 神谷 尚宏, 長谷川 大輔, 中島 健太郎, 吉田 健一, 小川 千登世, 小澤 美和, 真部 淳, 細谷 亮太
小児がん, 46, プログラム・総会号, 302, 302, (NPO)日本小児がん学会, Nov. 2009
Japanese

小児がん患児のきょうだいにおける心理・社会的問題の検討 きょうだいの心理的現状　　　　　　　　　　　　　　　
小林 明雪子, 小澤 美和, 阿佐美 百合子, 長谷川 大輔, 小川 千登世, 石田 也寸志, 真部 淳, 細谷 亮太
小児がん, 46, プログラム・総会号, 346, 346, (NPO)日本小児がん学会, Nov. 2009
Japanese

小児がん患児のきょうだいにおける心理・社会的問題の検討 きょうだい自身の意見　　　　　　　　　　　　　　　
小林 明雪子, 小澤 美和, 阿佐美 百合子, 長谷川 大輔, 小川 千登世, 石田 也寸志, 真部 淳, 細谷 亮太
小児がん, 46, プログラム・総会号, 346, 346, (NPO)日本小児がん学会, Nov. 2009
Japanese

家族性網膜芽細胞腫の治療後に2次性の横紋筋肉腫を発症した一例　　　　　　　　　　　　　　　
中島 健太郎, 山本 剛士, 笠井 恵美, 吉田 健一, 平林 真介, 神谷 尚宏, 長谷川 大輔, 小川 千登世, 石田 也寸志, 小澤 美和, 真部 淳, 細谷 亮太
小児がん, 46, プログラム・総会号, 369, 369, (NPO)日本小児がん学会, Nov. 2009
Japanese

MYCN増幅の獲得とともに進行性の経過をたどった神経芽腫StageIVの乳児例　　　　　　　　　　　　　　　
吉田 健一, 真部 淳, 山本 剛士, 中島 健太郎, 平林 真介, 神谷 尚宏, 長谷川 大輔, 小川 千登世, 小澤 美和, 中村 晃子, 平林 健, 藤原 美恵子, 鈴木 高祐, 中川 温子, 上條 岳彦, 中川原 章, 細谷 亮太
小児がん, 46, プログラム・総会号, 370, 370, (NPO)日本小児がん学会, Nov. 2009
Japanese

小児がんに罹患した子どもの同胞への心理面でのケア 弟を亡くした3歳児の事例から　　　　　　　　　　　　　　　
武田 洋子, 小澤 美和, 相良ローゼンマイヤ みはる, 真部 淳, 小川 千登世, 長谷川 大輔, 神谷 尚宏, 平林 真介, 吉田 健一, 中島 健太郎, 山本 剛士, 細谷 亮太
小児がん, 46, プログラム・総会号, 416, 416, (NPO)日本小児がん学会, Nov. 2009
Japanese

小児がん患者が退院後に抱える病気や体調面に関する困難の検討　　　　　　　　　　　　　　　
武井 優子, 尾形 明子, 鈴木 伸一, 小澤 美和, 盛武 浩, 平井 啓, 真部 淳
小児がん, 46, プログラム・総会号, 419, 419, (NPO)日本小児がん学会, Nov. 2009
Japanese

The ex vivo production of ammonia predicts L-asparaginase biological activity in children with acute lymphoblastic leukemia
Shizuka Watanabe, Kumiko Miyake, Chitose Ogawa, Haruna Matsumoto, Kenichi Yoshida, Shinsuke Hirabayashi, Daisuke Hasegawa, Tadao Inoue, Junko Kizu, Reiko Machida, Akira Ohara, Ryota Hosoya, Atsushi Manabe
INTERNATIONAL JOURNAL OF HEMATOLOGY, 90, 3, 347, 352, Oct. 2009, [Peer-reviewed]
English, Scientific journal

Detection of submicroscopic disease in the bone marrow and unaffected testis of a child with T-cell acute lymphoblastic leukemia who experienced "isolated" testicular relapse
Keitaro Arima, Daisuke Hasegawa, Chitose Ogawa, Itaru Kato, Toshihiro Imamura, Ayako Takusagawa, Hiroka Takahashi, Yoshiro Kitagawa, Toshinari Hori, Masahito Tsurusawa, Atsushi Manabe, Ryota Hosoya
INTERNATIONAL JOURNAL OF HEMATOLOGY, 90, 3, 370, 373, Oct. 2009, [Peer-reviewed]
English, Scientific journal

乳癌患者の闘病生活がその子どもへ与える心理・行動学影響　　　　　　　　　　　　　　　
小澤 美和, 伊藤 ゆかり, 真部 淳, 山内 英子, 中村 清吾, 細谷 亮太
日本癌治療学会誌, 44, 2, 845, 845, (一社)日本癌治療学会, Sep. 2009
Japanese

発作性の左下肢感覚異常に引き続いて部分運動発作重積状態を呈した右頭頂葉てんかんの一例(A case of right parietal lobe epilepsy showing repetitive paroxysmal irritation of left lower extremity developing clonic seizure of left leg)　　　　　　　　　　　　　　　
笠井 恵美, 山本 剛士, 吉田 健一, 中島 健太郎, 小澤 美和, 真部 淳, 草川 功, 細谷 亮太, 荻原 正明
てんかん研究, 27, 2, 266, 266, (一社)日本てんかん学会, Sep. 2009
English

Metachronous gliomas following cranial irradiation for mixed germ cell tumors
Akari Makidono, Nobuo Kobayashi, Yukihisa Saida, Atsushi Manabe, Jiro Kawamori, Koyu Suzuki
CHILDS NERVOUS SYSTEM, 25, 6, 713, 718, Jun. 2009, [Peer-reviewed]
English, Scientific journal

9 colorフローサイトメトリーによる小児白血病のマーカー解析　　　　　　　　　　　　　　　
清河 信敬, 恩田 恵子, 高野 邦彦, 藤本 純一郎, 真部 淳, 康 勝好, 小原 明, 林 泰秀, 花田 良二, 土田 昌宏
Cytometry Research, 19, 抄録集, 56, 56, (一社)日本サイトメトリー学会, Jun. 2009
Japanese

Correlation of Clinical Features With the Mutational Status of GM-CSF Signaling Pathway-Related Genes in Juvenile Myelomonocytic Leukemia
Nao Yoshida, Hiroshi Yagasaki, Yinyan Xu, Kazuyuki Matsuda, Ayami Yoshimi, Yoshiyuki Takahashi, Asahito Hama, Nobuhiro Nishio, Hideki Muramatsu, Nobuhiro Watanabe, Kimikazu Matsumoto, Koji Kato, Junichi Ueyama, Hiroko Inada, Hiroaki Goto, Miharu Yabe, Kazuko Kudo, Junichi Mimaya, Akira Kikuchi, Atsushi Manabe, Kenichi Koike, Seiji Kojima
PEDIATRIC RESEARCH, 65, 3, 334, 340, Mar. 2009, [Peer-reviewed]
English, Scientific journal

当院乳児健診受診児における排便状況と関連因子の検討　　　　　　　　　　　　　　　
中川 真智子, 鶴田 志緒, 中村 晃子, 小澤 美和, 真部 淳, 草川 功, 松藤 凡, 細谷 亮太
日本小児科学会雑誌, 113, 2, 350, 350, (公社)日本小児科学会, Feb. 2009
Japanese

頸部絞扼事故を契機に診断した広範性発達障害の一例　　　　　　　　　　　　　　　
山本 剛士, 笠井 恵美, 吉田 健一, 中島 健太郎, 平林 真介, 有馬 慶太郎, 小澤 美和, 真部 淳, 草川 功, 細谷 亮太
日本小児科学会雑誌, 113, 2, 359, 359, (公社)日本小児科学会, Feb. 2009
Japanese

親と死別する子どもへの介入の経験　　　　　　　　　　　　　　　
小澤 美和, 真部 淳, 石田 也寸志, 草川 功, 細谷 亮太
日本小児科学会雑誌, 113, 2, 457, 457, (公社)日本小児科学会, Feb. 2009
Japanese

聖路加国際病院のレジデント教育(第14報) 後期研修医の受け入れを開始してから　　　　　　　　　　　　　　　
比嘉 千明, 吉田 健一, 中島 健太郎, 有馬 慶太郎, 平林 信介, 小澤 美和, 真部 淳, 草川 功, 細谷 亮太
日本小児科学会雑誌, 113, 2, 464, 464, (公社)日本小児科学会, Feb. 2009
Japanese

01. 脾臓摘出術を先行して同種臍帯血移植を行った再発急性巨核芽球性白血病の1例(一般演題,第22回日本小児脾臓研究会)
長谷川 大輔, 神谷 尚宏, 吉田 健一, 中島 健太郎, 有馬 健太郎, 平林 真介, 中村 晃子, 平林 健, 松藤 凡, 小川 高史, 藤原 美恵子, 鈴木 高祐, 小川 千登世, 真部 淳, 細谷 亮太
日本小児外科学会雑誌, 45, 4, 803, 803, 特定非営利活動法人 日本小児外科学会, 2009
Japanese

A conditioning regimen of busulfan, fludarabine, and melphalan for allogeneic stem cell transplantation in children with juvenile myelomonocytic leukemia
Miharu Yabe, Masahiro Sako, Hiromasa Yabe, Yuko Osugi, Hidemitsu Kurosawa, Taemi Nara, Mika Tokuyama, Souichi Adachi, Chie Kobayashi, Masakatsu Yanagimachi, Yoshitoshi Ohtsuka, Yozo Nakazawa, Chitose Ogawa, Atsushi Manabe, Seiji Kojima, Tatsutoshi Nakahata
PEDIATRIC TRANSPLANTATION, 12, 8, 862, 867, Dec. 2008, [Peer-reviewed]
English, Scientific journal

Clinicopathological characteristics of erythroblast-rich RAEB and AML M6a in children
Yuko Honda, Atsushi Manabe, Masahiro Tsuchida, Yuji Zaike, Atsuko Masunaga, Masami Inoue, Ryoji Kobayashi, Yoshitoshi Ohtsuka, Akira Kikuchi, Tatsutoshi Nakahata
INTERNATIONAL JOURNAL OF HEMATOLOGY, 88, 5, 524, 529, Dec. 2008, [Peer-reviewed]
English, Scientific journal

Diagnosis and classification of myelodysplastic syndrome: International Working Group on Morphology of myelodysplastic syndrome (IWGM-MDS) consensus proposals for the definition and enumeration of myeloblasts and ring sideroblasts
Ghulam J. Mufti, John M. Bennett, Jean Goasguen, Barbara J. Bain, Irith Baumann, Richard Brunning, Mario Cazzola, Pierre Fenaux, Ulrich Germing, Eva Hellstrom-Lindberg, Itsuro Jinnai, Atsushi Manabe, Akira Matsuda, Charlotte M. Niemeyer, Guillermo Sanz, Masao Tomonaga, Teresa Vallespi, Ayami Yoshimi
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 93, 11, 1712, 1717, Nov. 2008, [Peer-reviewed]
English, Scientific journal

肺転移を伴う骨肉腫症例に対する外科的肺転移巣切除の意義　　　　　　　　　　　　　　　
中村 晃子, 松藤 凡, 平林 健, 小川 千登世, 真部 淳, 細谷 亮太
小児がん, 45, プログラム・総会号, 317, 317, (NPO)日本小児がん学会, Nov. 2008
Japanese

自家および同種造血幹細胞移植を含む集学的治療を行った右胸壁原発PNETの一例　　　　　　　　　　　　　　　
神谷 尚宏, 真部 淳, 小川 千登世, 有馬 慶太郎, 平林 真介, 長谷川 大輔, 河守 次郎, 関口 建次, 中村 晃子, 松藤 凡, 細谷 亮太
小児がん, 45, プログラム・総会号, 400, 400, (NPO)日本小児がん学会, Nov. 2008
Japanese

ALL標準危険群に対するTCCSG治療戦略の変遷 TCCSG ALL L-89-12,92-13,95-14,99-15研究　　　　　　　　　　　　　　　
康 勝好, 小原 明, 磯山 恵一, 梶原 道子, 小池 和俊, 金澤 崇, 嶋田 博之, 田中 竜平, 熊谷 昌明, 木下 明俊, 杉田 完爾, 杉田 憲一, 真部 淳, 林 泰秀, 前田 美穂, 花田 良二, 土田 昌宏
小児がん, 45, プログラム・総会号, 189, 189, (NPO)日本小児がん学会, Nov. 2008
Japanese

東京小児がん研究グループ(TCCSG)急性リンパ性白血病(ALL)マーカー中央診断におけるT-ALLのマーカー解析　　　　　　　　　　　　　　　
恩田 恵子, 清河 信敬, 藤本 純一郎, 齋藤 正博, 大喜多 肇, 梶原 道子, 福島 敬, 犬飼 岳史, 牧本 敦, 真部 淳, 康 勝好, 中川 温子, 小原 明, 林 泰秀, 花田 良二, 土田 昌宏
小児がん, 45, プログラム・総会号, 190, 190, (NPO)日本小児がん学会, Nov. 2008
Japanese

小児急性リンパ性白血病に対する寛解導入療法・早期強化療法の安全性に関する検討 TCCSG L04-16研究　　　　　　　　　　　　　　　
小嶋 靖子, 太田 節雄, 牧本 敦, 小原 明, 福島 啓太郎, 福島 敬, 犬飼 岳史, 秋山 政晴, 子川 和宏, 矢部 普正, 康 勝好, 清河 信敬, 真部 淳, 林 泰秀, 花田 良二, 土田 昌宏, 東京小児がん研究グループALL委員会・支持療法委員会
小児がん, 45, プログラム・総会号, 194, 194, (NPO)日本小児がん学会, Nov. 2008
Japanese

小児急性リンパ性白血病標準危険群治療における入院期間の後方視的検討　　　　　　　　　　　　　　　
望月 慎史, 菊地 陽, 後藤 裕明, 太田 節雄, 富澤 大輔, 廣瀬 衣子, 加藤 陽子, 前田 美穂, 磯山 恵一, 小原 明, 真部 淳, 花田 良二, 土田 昌宏
小児がん, 45, プログラム・総会号, 193, 193, (NPO)日本小児がん学会, Nov. 2008
Japanese

小児がん経験者のPosttraumatic stress symptomsの時間経過による変化　　　　　　　　　　　　　　　
小澤 美和, 阿佐美 百合子, 平林 真介, 神谷 尚宏, 長谷川 大輔, 小川 千登勢, 石田 也寸志, 真部 淳, 細谷 亮太
小児がん, 45, プログラム・総会号, 222, 222, (NPO)日本小児がん学会, Nov. 2008
Japanese

化学療法施行に際してClostridium difficile関連下痢症を発症した6例の検討　　　　　　　　　　　　　　　
吉田 健一, 長谷川 大輔, 笠井 恵美, 山本 剛士, 中島 健太郎, 比嘉 千明, 平林 真介, 有馬 慶太郎, 神谷 尚宏, 小川 千登世, 稲井 郁子, 小澤 美和, 真部 淳, 細谷 亮太
小児がん, 45, プログラム・総会号, 249, 249, (NPO)日本小児がん学会, Nov. 2008
Japanese

小児がん患者における知的発達のフォローアップ　　　　　　　　　　　　　　　
渡辺 静, 阿佐美 百合子, 真部 淳, 長谷川 大輔, 小川 千登世, 小澤 美和, 石田 也寸志, 木津 純子, 細谷 亮太
小児がん, 45, プログラム・総会号, 254, 254, (NPO)日本小児がん学会, Nov. 2008
Japanese

医療従事者のグリーフケアについての検討　　　　　　　　　　　　　　　
山本 光映, 永瀬 恭子, 宮坂 真紗規, 中村 かおり, 吉川 久美子, 阿佐美 百合子, 小川 千登世, 小澤 美和, 真部 淳, 細谷 亮太
小児がん, 45, プログラム・総会号, 257, 257, (NPO)日本小児がん学会, Nov. 2008
Japanese

germ cell tumorに対する治療終了から3年後に発症したglioblastomaの症例　　　　　　　　　　　　　　　
比嘉 千明, 中島 健太郎, 有馬 慶太郎, 平林 真介, 長谷川 大輔, 小川 千登世, 真部 淳, 小澤 美和, 関口 建次, 細谷 亮太, 伊藤 昌徳
小児がん, 45, プログラム・総会号, 293, 293, (NPO)日本小児がん学会, Nov. 2008
Japanese

川崎病と同時に発症したMyeloid/NK前駆細胞性急性白血病の例　　　　　　　　　　　　　　　
有馬 慶太郎, 真部 淳, 吉田 健一, 平林 真介, 神谷 尚宏, 長谷川 大輔, 小川 千登世, 小澤 美和, 海老原 康博, 土屋 恵司, 細谷 亮太
小児がん, 45, プログラム・総会号, 301, 301, (NPO)日本小児がん学会, Nov. 2008
Japanese

小児がん経験者の身体的晩期合併症 身長と体重に対する検討　　　　　　　　　　　　　　　
小松 なぎさ, 吉田 健一, 中島 健太郎, 平林 真介, 有馬 慶太郎, 神谷 尚宏, 長谷川 大輔, 小川 千登世, 小澤 美和, 真部 淳, 石田 也寸志, 細谷 亮太
小児がん, 45, プログラム・総会号, 380, 380, (NPO)日本小児がん学会, Nov. 2008
Japanese

Successful Reduction of Cranial Irradiation in Children with B Cell Precursor Acute Lymphoblastic Leukemia(ALL) through Four Consecutive ALL Studies: Long-Term Follow-up of ALL in Tokyo Children's Cancer Study Group (TCCSG) L89-12, 92-13, 95-14 and 99-15 Studies
Chitose Ogawa, Akira Ohara, Atsushi Manabe, Akira Kikuchi, Katsuyoshi Koh, Daisuke Tomizawa, Junya Fujimura, Hiroyasu Inoue, Syosuke Sunami, Eizaburo Ishii, Masaaki Shiohara, Tetsuya Mori, Hiroyuki Takahashi, Yasuhide Hayashi, Ryoji Hanada, Masahiro Tsuchida
BLOOD, 112, 11, 338, 339, Nov. 2008, [Peer-reviewed]
English

Myelodysplastic Syndrome (MDS) and Myeloproliferative Disease (MPD) in Children: A Prospective Registration of 222 Cases
Shinsuke Hirabayashi, Atsushi Manabe, Shizuka Watanabe, Yuji Zaike, Masahiro Tsuchida, Atsuko Masunaga, Ayami Yoshimi, Masafumi Ito, Akira Kikuchi, Kohichiro Tsuji, Akira Ohara, Seiji Kojima, Tatsutoshi Nakahata
BLOOD, 112, 11, 926, 926, Nov. 2008, [Peer-reviewed]
English

[Pediatric hematology for internists].
Manabe A
[Rinsho ketsueki] The Japanese journal of clinical hematology, 49, 10, 1341, 1348, Oct. 2008, [Peer-reviewed]

Mutation analysis of SIPA1 in patients with juvenile myelomonocytic leukemia
Hugues de lavallade, Philippe A. Cassier, Reda Bouabdallah, Jean El-Cheikh, Catherine Faucher, Sabine Fuerst, Diane Coso, Danielle Sainty, Christine Arnoulet, Jean-Albert Gastaut, Bruno Chetaille, Luc Xerri, Didier Blaise, Mohamad Mohty
BRITISH JOURNAL OF HAEMATOLOGY, 142, 5, 850, 851, Sep. 2008, [Peer-reviewed]
English

小児急性リンパ性白血病におけるDay8ITの意義 東京小児がん研究グループ(TCCSG)L99-15研究より　　　　　　　　　　　　　　　
長谷川 大輔, 真部 淳, 小原 明, 富澤 大輔, 康 勝好, 小川 千登世, 花田 良二, 土田 昌宏
臨床血液, 49, 9, 921, 921, (一社)日本血液学会-東京事務局, Sep. 2008
Japanese

小児ALLに対する化学療法早期の有効性と安全性の検討 TCCSG ALL L04-16研究　　　　　　　　　　　　　　　
小原 明, 真部 淳, 牧本 敦, 康 勝好, 小川 千登世, 磯山 恵一, 杉田 憲一, 杉田 完爾, 野口 靖, 太田 節雄, 前田 美穂, 矢部 普正, 金子 隆, 熊谷 昌明, 梶原 道子, 高橋 浩之, 菊地 陽, 嶋田 博之, 外松 学, 福島 敬, 齋藤 正博, 林 泰秀, 花田 良二, 土田 昌宏
臨床血液, 49, 9, 921, 921, (一社)日本血液学会-東京事務局, Sep. 2008
Japanese

高密度SNPマイクロアレイを用いた本邦の小児急性リンパ芽球性白血病のmolecular karyotyping　　　　　　　　　　　　　　　
清河 信敬, 加藤 元博, 藤本 純一郎, 宮川 世志幸, 恩田 恵子, 大喜多 肇, 齋藤 正博, 牧本 敦, 真部 淳, 康 勝好, 小原 明, 林 泰秀, 花田 良二, 土田 昌宏, 小川 誠司
臨床血液, 49, 9, 1203, 1203, (一社)日本血液学会-東京事務局, Sep. 2008
Japanese

Significance of the complete clearance of peripheral blasts after 7 days of prednisolone treatment in children with acute lymphoblastic leukemia: the Tokyo Children's Cancer Study Group Study L99-15
Atsushi Manabe, Akira Ohara, Daisuke Hasegawa, Katsuyoshi Koh, Tomohiro Saito, Nobutaka Kiyokawa, Akira Kikuchi, Hiroyuki Takahashi, Koichiro Ikuta, Yasuhide Hayashi, Ryoji Hanada, Masahiro Tsuchida
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 93, 8, 1155, 1160, Aug. 2008, [Peer-reviewed]
English, Scientific journal

Mutation analysis of AML1 gene in pediatric primary myelodysplastic syndrome and juvenile myelomonocytic leukemia
Atsuko Masunaga, Toshiyuki Mitsuya, Tsuyoki Kadoftiku, Sanju Iwamoto, Akira Miyazaki, Atsushi Manabe, Yuji Zaike, Masahiro Tsuchida, Tatsutoshi Nakahata
LEUKEMIA RESEARCH, 32, 6, 995, 997, Jun. 2008, [Peer-reviewed]
English

小児がんの治療における中枢神経障害の検討.　　　　　　　　　　　　　　　
渡辺静, 阿佐美百合子, 真部淳, 小川千登世, 長谷川大輔, 小澤美和, 木津純子, 井上忠夫, 細谷亮太
日本小児がん学会雑誌, 45(2), 45(2), Jun. 2008, [Peer-reviewed]
Japanese, Symposium

Picture in Clinical Hematology No. 25
平林 真介, 吉田 健一, 中島 健太郎, 有馬 慶太郎, 長谷川 大輔, 小川 千登世, 真部 淳, 細谷 亮太
Rinsho Ketsueki, 49, 3, 139, 139, The Japanese Society of Hematology, 30 Mar. 2008
Japanese

Iodine-131-metaiodobenzyguanidine therapy with reduced-intensity allogeneic stem cell transplantation in recurrent neuroblastoma
Hiroka Takahashi, Atsushi Manabe, Chiaki Aoyama, Takahiro Kamiya, Itaru Kato, Ayako Takusagawa, Chitose Ogawa, Miwa Ozawa, Ryota Hosoya, Kunihiko Yokoyama
PEDIATRIC BLOOD & CANCER, 50, 3, 676, 678, Mar. 2008, [Peer-reviewed]
English, Scientific journal

Desmoplastic small round cell tumorが疑われた縦隔肉腫の乳児例
平林 真介, 青山 千晶, 伊藤 雄伍, 今村 壽宏, 加藤 格, 神谷 尚宏, 藤田 真智子, 小澤 美和, 真部 淳, 細谷 亮太, 森本 克, 松藤 凡, 鈴木 高祐, 田中 祐吉, 秦 順一
小児がん, 45, 1, 36, 40, (NPO)日本小児がん学会, Feb. 2008
Japanese

小児がん経験者のsexualityを支援するフォローアップ外来を立ち上げて　　　　　　　　　　　　　　　
巷岡 彩子, 小澤 美和, 鈴木 麻水, 塩田 恭子, 佐藤 孝道, 有馬 慶太郎, 平林 真介, 小川 千登世, 真部 淳, 細谷 亮太
日本小児科学会雑誌, 112, 2, 278, 278, (公社)日本小児科学会, Feb. 2008
Japanese

聖路加国際病院小児科レジデント教育の現況(第13報) 電子カルテが教育へ及ぼす影響　　　　　　　　　　　　　　　
有馬 慶太郎, 平林 真介, 中川 真智子, 長谷川 大輔, 小川 千登世, 稲井 郁子, 小澤 美和, 真部 淳, 草川 功, 細谷 亮太
日本小児科学会雑誌, 112, 2, 329, 329, (公社)日本小児科学会, Feb. 2008
Japanese

Wiskott-Aldrich syndrome is an important differential diagnosis in male infants with juvenile myelomonocytic leukemialike features
Nobuhiro Watanabe, Ayami Yoshimi, Yoshiro Kamachi, Takashi Kawabe, Hideki Muramatsu, Kimikazu Matsumoto, Atsushi Manabe, Seiji Kojima, Koji Kato
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 29, 12, 836, 838, Dec. 2007, [Peer-reviewed]
English, Scientific journal

The effect of donor leukocyte infusion on refractory pure red blood cell aplasia after allogeneic stem cell transplantation in a patient with myelodysplastic syndrome developing from Kostmann syndrome
Yasuhiro Ebihara, Atsushi Manabe, Toshihisa Tsuruta, Kumiko Ishikawa, Daisuke Hasegawa, Yoshitoshi Ohtsuka, Hirohide Kawasaki, Kazuo Ogami, Yuka Wada, Tadayasu Kanda, Kohichiro Tsuji
INTERNATIONAL JOURNAL OF HEMATOLOGY, 86, 5, 446, 450, Dec. 2007, [Peer-reviewed]
English, Scientific journal

小児Castleman病の2例　　　　　　　　　　　　　　　
有馬 慶太郎, 稲井 郁子, 真部 淳, 長谷川 大輔, 小川 千登世, 細谷 亮太, 荒木 夕宇子, 中村 晃子, 松藤 凡, 竹内 敏雄, 三輪 操子, 上松 一永
小児感染免疫, 19, 4, 490, 490, (一社)日本小児感染症学会, Dec. 2007
Japanese

自家末梢血幹細胞移植後に消化管出血、VOD、肺出血を来たし死亡した神経芽腫の1例　　　　　　　　　　　　　　　
吉田 健一, 長谷川 大輔, 平林 真介, 有馬 慶太郎, 小川 千登世, 真部 淳, 中村 晃子, 松藤 凡, 細谷 亮太
小児がん, 44, プログラム・総会号, 237, 237, (NPO)日本小児がん学会, Dec. 2007
Japanese

肺転移を伴ったWilms腫瘍に対して治療終了のタイミングを開胸肺生検で決定した2例についての検討　　　　　　　　　　　　　　　
中村 晃子, 松藤 凡, 平林 健, 小川 千登世, 真部 淳, 細谷 亮太
小児がん, 44, プログラム・総会号, 356, 356, (NPO)日本小児がん学会, Dec. 2007
Japanese

診断に難渋した左上顎洞腫瘍の1女児例　　　　　　　　　　　　　　　
苛原 香, 真部 淳, 小川 千登世, 長谷川 大輔, 田草川 彩子, 高橋 宏佳, 今西 康次, 有馬 慶太郎, 平林 真介, 細谷 亮太, 中村 晃子, 荒木 夕宇子, 松藤 凡, 鈴木 高祐, 岸本 誠司
小児がん, 44, プログラム・総会号, 367, 367, (NPO)日本小児がん学会, Dec. 2007
Japanese

急性リンパ性白血病の染色体・遺伝子異常と予後 TCCSG ALL L95-14・L99-15研究　　　　　　　　　　　　　　　
高橋 浩之, 小原 明, 齋藤 正博, 福島 敬, 梶原 道子, 小嶋 靖子, 菊地 陽, 小川 千登世, 前田 美穂, 塩原 正明, 康 勝好, 真部 淳, 林 泰秀, 花田 良二, 土田 昌宏, 東京小児がん研究グループ(TCCSG)ALL委員会
小児がん, 44, プログラム・総会号, 179, 179, (NPO)日本小児がん学会, Dec. 2007
Japanese

東京小児がん研究グループALL治療第16次研究(TCCSG L04-16/06-16)におけるマーカー中央診断　　　　　　　　　　　　　　　
清河 信敬, 藤本 純一郎, 田口 智子, 塩沢 裕介, 斉藤 洋平, 大喜多 肇, 梶原 道子, 福島 敬, 河崎 裕英, 犬飼 岳史, 牧本 敦, 真部 淳, 康 勝好, 小原 明, 林 泰秀, 花田 良二, 土田 昌宏
小児がん, 44, プログラム・総会号, 180, 180, (NPO)日本小児がん学会, Dec. 2007
Japanese

1歳の小児急性リンパ性白血病の臨床像及び治療成績の検討 東京小児がん研究グループ(TCCSG)からの報告　　　　　　　　　　　　　　　
富澤 大輔, 磯山 恵一, 小原 明, 福島 啓太郎, 金子 隆, 加藤 陽子, 野口 靖, 太田 節雄, 嶋田 博之, 矢部 普正, 康 勝好, 真部 淳, 林 泰秀, 花田 良二, 土田 昌宏
小児がん, 44, プログラム・総会号, 172, 172, (NPO)日本小児がん学会, Dec. 2007
Japanese

骨・軟部腫瘍患児の術前/術後の面接から疾患の受け止め方を考える　　　　　　　　　　　　　　　
小澤 美和, 阿佐美 百合子, 有馬 慶太郎, 平林 真介, 長谷川 大輔, 小川 千登勢, 真部 淳, 細谷 亮太
小児がん, 44, プログラム・総会号, 206, 206, (NPO)日本小児がん学会, Dec. 2007
Japanese

小児がん患者長期フォローアップの実践 当院の最近20年間の実態調査　　　　　　　　　　　　　　　
渡辺 静, 真部 淳, 長谷川 大輔, 小川 千登世, 小澤 美和, 井上 忠夫, 木津 純子, 森本 克, 西村 昴三, 細谷 亮太
小児がん, 44, プログラム・総会号, 245, 245, (NPO)日本小児がん学会, Dec. 2007
Japanese

Acute myeloid leukemia with multifineage dysplasia in children
Souichi Adachi, Atsushi Manabe, Masue Imaizumi, Takashi Taga, Akio Tawa, Masahito Tsurusawa, Akira Kikuchi, Atsuko Masunaga, Masahiro Tsuchida, Tatsutoshi Nakahata
INTERNATIONAL JOURNAL OF HEMATOLOGY, 86, 4, 358, 363, Nov. 2007, [Peer-reviewed]
English, Scientific journal

上顎洞原発粘液性軟骨肉腫の1女児例
苛原 香, 真部 淳, 小川 千登世, 平林 真介, 田草川 彩子, 高橋 宏佳, 今西 康次, 有賀 慶太郎, 長谷川 大輔, 細谷 亮太, 中村 晃子, 荒木 夕宇子, 松藤 凡, 鈴木 高祐, 岸本 誠司
小児がん, 44, 2, 198, 198, (NPO)日本小児がん学会, Sep. 2007
Japanese

TCCSG L95-14およびL99-15にて治療後に再発した小児急性リンパ性白血病の予後　　　　　　　　　　　　　　　
小川 千登世, 康 勝好, 金子 隆, 後藤 裕明, 太田 節雄, 真部 淳, 小原 明, 花田 良二, 土田 昌宏
臨床血液, 48, 9, 936, 936, (一社)日本血液学会-東京事務局, Sep. 2007
Japanese

小児がん経験者のsexualityを支援するfollow up外来を立ち上げて　　　　　　　　　　　　　　　
巷岡 彩子, 小澤 美和, 鈴木 麻水, 塩田 恭子, 佐藤 孝道, 有馬 慶太郎, 長谷川 大輔, 小川 千登世, 真部 淳, 細谷 亮太
臨床血液, 48, 9, 975, 975, (一社)日本血液学会-東京事務局, Sep. 2007
Japanese

小児Castleman病の2例　　　　　　　　　　　　　　　
有馬 慶太郎, 稲井 郁子, 真部 淳, 平林 真介, 高橋 宏佳, 田草川 彩子, 長谷川 大輔, 小川 千登世, 荒木 夕宇子, 中村 晃子, 松藤 凡, 細谷 亮太, 竹内 敏雄, 三輪 操子, 上松 一永
日本小児科学会雑誌, 111, 7, 912, 912, (公社)日本小児科学会, Jul. 2007
Japanese

小児がん患児のきょうだいにおける心理的問題の検討
小澤 美和, 泉 真由子, 森本 克, 真部 淳, 細谷 亮太
日本小児科学会雑誌, 111, 7, 847, 854, (公社)日本小児科学会, Jul. 2007
Japanese

Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations
Kazuyuki Matsuda, Akira Shimada, Nao Yoshida, Atsushi Ogawa, Akihiro Watanabe, Shuhei Yajima, Susumu Iizuka, Kazutoshi Koike, Fumio Yanai, Keiichiro Kawasaki, Masakatsu Yanagimachi, Akira Kikuchi, Yoshitoshi Ohtsuka, Eiko Hidaka, Kazuyoshi Yamauchi, Miyuki Tanaka, Ryu Yanagisawa, Yozo Nakazawa, Masaaki Shiohara, Atsushi Manabe, Seiji Kojima, Kenichi Koike
BLOOD, 109, 12, 5477, 5480, Jun. 2007, [Peer-reviewed]
English, Scientific journal

当科で経験したOncologic surgical emergencyについての検討　　　　　　　　　　　　　　　
中村 晃子, 松藤 凡, 荒木 夕宇子, 真部 淳, 草川 功, 細谷 亮太
日本小児救急医学会雑誌, 6, 1, 116, 116, (一社)日本小児救急医学会, Jun. 2007
Japanese

Development of diffuse large B cell lymphoma during the maintenance therapy for B-lineage acute lymphoblastic leukemia
Itaru Kato, Atsushi Manabe, Chiaki Aoyama, Takahiro Kamiya, Tsuyoshi Morimoto, Hiroshi Matsufuji, Koyu Suzuki, Yoshiro Kitagawa, Toshinori Hori, Masahito Tsurusawa, Nobutaka Kiyokawa, Junichiro Fujimoto, Ryota Hosoya
PEDIATRIC BLOOD & CANCER, 48, 2, 230, 232, Feb. 2007, [Peer-reviewed]
English, Scientific journal

小児Castleman病の2例　　　　　　　　　　　　　　　
有馬 慶太郎, 稲井 郁子, 真部 淳, 小川 千登世, 荒木 夕宇子, 松藤 凡, 竹内 敏雄, 三輪 操子, 上松 一永, 細谷 亮太
日本小児科学会雑誌, 111, 2, 249, 249, (公社)日本小児科学会, Feb. 2007
Japanese

聖路加国際病院小児科レジデント教育の現況(第12報) 新臨床研修制度への対応　　　　　　　　　　　　　　　
今村 壽宏, 有馬 慶太郎, 平林 真介, 高橋 宏佳, 田草川 彩子, 小澤 美和, 真部 淳, 草川 功, 細谷 亮太
日本小児科学会雑誌, 111, 2, 316, 316, (公社)日本小児科学会, Feb. 2007
Japanese

Immunosuppressive therapy in children with refractory anemia: Results of Japanese childhood MDS study group trial (MDS99).
Daisuke Hasegawa, Hiroshi Yagasaki, Yoshitoshi Ohtsuka, Masami Inoue, Akira Kikuchi, Akira Ohara, Masahiro Tsuchida, Seiji Kojima, Atsushi Manabe, Tatsutoshi Nakahata
BLOOD, 108, 11, 756A, 756A, Nov. 2006, [Peer-reviewed]
English

健常腎温存のための治療方針選択に苦慮した、両側ウィルムス腫瘍(stage V,FRN)の1例　　　　　　　　　　　　　　　
荒木 夕宇子, 松藤 凡, 中村 晃子, 細谷 亮太, 真部 淳, 小川 千登世
日本小児血液学会雑誌, 20, 5, 332, 332, 日本小児血液学会, Oct. 2006
Japanese

当院で経験したユーイング肉腫ファミリー腫瘍10例の治療についての検討　　　　　　　　　　　　　　　
中村 晃子, 松藤 凡, 荒木 夕宇子, 道川 武紘, 小川 千登世, 真部 淳, 細谷 亮太
日本小児血液学会雑誌, 20, 5, 402, 402, 日本小児血液学会, Oct. 2006
Japanese

下大静脈合併切除を行ったStageIVのWilms腫瘍　　　　　　　　　　　　　　　
道川 武紘, 松藤 凡, 荒木 夕宇子, 中村 晃子, 小川 千登世, 真部 淳, 細谷 亮太
日本小児血液学会雑誌, 20, 5, 411, 411, 日本小児血液学会, Oct. 2006
Japanese

TEL/AML1陽性急性リンパ性白血病におけるday15BM芽球比率の重要性　　　　　　　　　　　　　　　
野口 靖, 小原 明, 真部 淳, 太田 節雄, 高橋 浩之, 福島 啓太郎, 杉田 憲一, 小川 千登世, 菊池 陽, 康 勝好, 生田 孝一郎, 林 泰秀, 花田 良二, 土田 昌宏
日本小児血液学会雑誌, 20, 5, 500, 500, 日本小児血液学会, Oct. 2006
Japanese

TCCSG L95-14およびL99-15にて治療後に再発した小児急性リンパ性白血病の予後　　　　　　　　　　　　　　　
小川 千登世, 康 勝好, 金子 隆, 太田 節雄, 後藤 裕明, 真部 淳, 小原 明, 花田 良二, 土田 昌宏
日本小児血液学会雑誌, 20, 5, 505, 505, 日本小児血液学会, Oct. 2006
Japanese

急性リンパ性白血病標準危険群・中間危険群に対する6MP/MTX漸増間歇維持療法の有効性の検討　　　　　　　　　　　　　　　
外松 学, 小原 明, 真部 淳, 金子 隆, 前田 美穂, 中舘 尚也, 福島 敬, 熊谷 昌明, 三浦 信之, 加藤 陽子, 生田 孝一郎, 林 泰秀, 花田 良二, 土田 昌宏, 東京小児がん研究グループ
日本小児血液学会雑誌, 20, 5, 360, 360, 日本小児血液学会, Oct. 2006
Japanese

最近当院で経験した骨肉腫の10症例　　　　　　　　　　　　　　　
田草川 彩子, 真部 淳, 加藤 格, 高橋 宏佳, 今村 壽宏, 有馬 慶太郎, 平林 真介, 長谷川 大輔, 小林 明雪子, 小川 千登世, 小澤 美和, 細谷 亮太, 真鍋 淳, 松本 誠一, 川口 智義
日本小児血液学会雑誌, 20, 5, 398, 398, 日本小児血液学会, Oct. 2006
Japanese

小児期に発症し、成人に持ち越した急性リンパ性白血病の2症例　　　　　　　　　　　　　　　
高橋 宏佳, 小澤 美和, 田草川 彩子, 長谷川 大輔, 小川 千登世, 真部 淳, 細谷 亮太, 塚崎 百合子, 西田 知佳子
日本小児血液学会雑誌, 20, 5, 425, 425, 日本小児血液学会, Oct. 2006
Japanese

小児悪性腫瘍患者における中枢神経障害の検討　　　　　　　　　　　　　　　
渡辺 静, 塚崎 百合子, 田草川 彩子, 長谷川 大輔, 小林 明雪子, 小川 千登世, 小澤 美和, 真部 淳, 細谷 亮太, 井上 忠夫, 木津 純子
日本小児血液学会雑誌, 20, 5, 435, 435, 日本小児血液学会, Oct. 2006
Japanese

心タンポナーデを合併したリンパ管腫症の1例　　　　　　　　　　　　　　　
田草川 彩子, 小川 千登世, 高橋 宏佳, 加藤 格, 今村 壽宏, 小澤 美和, 真部 淳, 細谷 亮太
日本小児血液学会雑誌, 20, 5, 454, 454, 日本小児血液学会, Oct. 2006
Japanese

東京小児がん研究グループTCCSG小児急性リンパ性白血病プロトコールALL L99-15研究中間解析　　　　　　　　　　　　　　　
小原 明, 真部 淳, 康 勝好, 磯山 恵一, 杉田 憲一, 杉田 完爾, 太田 節雄, 沖本 由理, 木下 明俊, 前田 美穂, 矢部 普正, 金子 隆, 熊谷 昌明, 上條 岳彦, 梶原 道子, 高橋 浩之, 菊地 陽, 小川 千登世, 外松 学, 福島 敬, 齋藤 正博, 別所 文雄, 生田 孝一郎, 齋藤 友博, 林 泰秀, 花田 良二, 土田 昌宏, 東京小児がん研究グループ
臨床血液, 47, 9, 1013, 1013, (一社)日本血液学会-東京事務局, Sep. 2006
Japanese

小児ALLにおけるPred反応性最良好群(Day8末梢血芽球ゼロ)の治療成績 TCCSG L99-15研究　　　　　　　　　　　　　　　
真部 淳, 小原 明, 康 勝好, 太田 節雄, 小川 千登世, 加藤 陽子, 後藤 裕明, 齋藤 正博, 嶋田 博之, 高橋 浩之, 富沢 大輔, 中舘 尚也, 野口 靖, 福島 啓太郎, 福島 敬, 牧本 敦, 三浦 信之, 林 泰秀, 生田 孝一郎, 齋藤 友博, 熊谷 昌明, 花田 良二, 土田 昌宏
臨床血液, 47, 9, 1030, 1030, (一社)日本血液学会-東京事務局, Sep. 2006
Japanese

初発時hyperleukocytosisをきたしたT cell ALLの3例　　　　　　　　　　　　　　　
田草川 彩子, 真部 淳, 高橋 宏佳, 今村 壽宏, 加藤 格, 神谷 尚宏, 長谷川 大輔, 小林 明雪子, 稲井 郁子, 小川 千登世, 小澤 美和, 細谷 亮太
臨床血液, 47, 9, 1257, 1257, (一社)日本血液学会-東京事務局, Sep. 2006
Japanese

Picture in Clinical Hematology
真部 淳
Rinsho Ketsueki, 47, 4, 255, 255, The Japanese Society of Hematology, 30 Apr. 2006
Japanese

Irinotecan for children with relapsed solid tumors
T Shitara, A Shimada, R Hanada, T Matsunaga, K Kawa, H Mugishima, T Sugimoto, JI Mimaya, A Manabe, M Tsurusawa, Y Tsuchida
PEDIATRIC HEMATOLOGY AND ONCOLOGY, 23, 2, 103, 110, Mar. 2006, [Peer-reviewed]
English, Scientific journal

聖路加国際病院小児科レジデント教育の現況(第11報) 新臨床研修制度が始まって　　　　　　　　　　　　　　　
神谷 尚宏, 伊藤 雄伍, 今村 寿宏, 加藤 格, 小川 千登世, 稲井 郁子, 小澤 美和, 真部 淳, 草川 功, 細谷 亮太
日本小児科学会雑誌, 110, 2, 282, 282, (公社)日本小児科学会, Feb. 2006
Japanese

学童期に経験した親との喪失体験の違いによる受容過程についての考察　　　　　　　　　　　　　　　
小澤 美和, 一ノ橋 祐子, 小川 千登世, 稲井 郁子, 森本 克, 真部 淳, 草川 功, 細谷 亮太
日本小児科学会雑誌, 110, 2, 330, 330, (公社)日本小児科学会, Feb. 2006
Japanese

P-52 最近10年間に当院で経験した10例のEwing肉腫/pPNETについての検討(示説13 腫瘍2・代謝,第43回 日本小児外科学会総会)
中村 晃子, 松藤 凡, 荒木 夕宇子, 細谷 亮太, 真部 淳
日本小児外科学会雑誌, 42, 3, 445, 445, 特定非営利活動法人 日本小児外科学会, 2006
Japanese

眼窩周囲炎・副鼻腔炎に続発した眼窩蜂窩織炎の1例
加藤 格, 今村 壽宏, 伊藤 雄伍, 神谷 尚宏, 藤田 真智子, 青山 千昌, 安西 有紀, 稲井 郁子, 小澤 美和, 森本 克, 真部 淳, 草川 功, 細谷 亮太, 小暮 朗子, 大越 貴志子, 山口 達夫
小児科臨床, 59, 1, 131, 136, (株)日本小児医事出版社, Jan. 2006
Japanese

RAS-blocking bisphosphonate zoledronic acid inhibits the abnormal proliferation and differentiation of juvenile myelomonocytic leukemia cells in vitro
Y Ohtsuka, A Manabe, H Kawasaki, D Hasegawa, Y Zaike, S Watanabe, T Tanizawa, T Nakahata, K Tsuji
BLOOD, 106, 9, 3134, 3141, Nov. 2005, [Peer-reviewed]
English, Scientific journal

眼窩周囲炎・副鼻腔炎に続発した眼窩蜂窩織炎の1例　　　　　　　　　　　　　　　
加藤 格, 今村 壽宏, 伊藤 雄伍, 神谷 尚宏, 藤田 真智子, 青山 千昌, 安西 有紀, 稲井 郁子, 小澤 美和, 森本 克, 真部 淳, 草川 功, 細谷 亮太
日本小児科学会雑誌, 109, 11, 1383, 1383, (公社)日本小児科学会, Nov. 2005
Japanese

鎖骨に生じたMRSA骨髄炎の1例　　　　　　　　　　　　　　　
平林 真介, 高橋 宏佳, 田草川 彩子, 伊藤 雄伍, 今村 壽宏, 加藤 格, 神谷 尚宏, 一ノ橋 裕子, 小川 千登世, 稲井 郁子, 小澤 美和, 真部 淳, 草川 功, 細谷 亮太
日本小児科学会雑誌, 109, 11, 1390, 1390, (公社)日本小児科学会, Nov. 2005
Japanese

11th symposium on aplastic anemia and 9th symposium on myelodysplastic syndromes in children
Atsushi Manabe, Seiji Kojima
Pediatrics International, 47, 5, 572, 574, Oct. 2005, [Peer-reviewed]
English, International conference proceedings

トータルケアの心と実践 地域共同診療(ウォーターフロント小児がん共同治療計画) 手術,化学療法,移植治療の分担と支援グループの共有　　　　　　　　　　　　　　　
松藤 凡, 荒木 夕宇子, 中村 晃子, 細谷 亮太, 真部 淳, 川口 智義, 高上 洋一, 牧本 敦
日本小児血液学会雑誌, 19, 5, 278, 278, 日本小児血液学会, Oct. 2005
Japanese

MDSの中央診断 骨髄生検の実施状況　　　　　　　　　　　　　　　
増永 敦子, 在家 裕司, 菅原 幸子, 土田 昌宏, 河崎 裕英, 真部 淳
日本小児血液学会雑誌, 19, 5, 299, 299, 日本小児血液学会, Oct. 2005
Japanese

小児11q23転座型急性リンパ性白血病(ALL)の第一寛解期移植による治療成績の向上　　　　　　　　　　　　　　　
齋藤 正博, 林 泰秀, 康 勝好, 高橋 浩之, 福島 敬, 太田 節雄, 真部 淳, 杉田 憲一, 杉田 完爾, 矢部 普正, 菊地 陽, 野口 靖, 生田 孝一郎, 小原 明, 花田 良二, 土田 昌宏, 東京小児がん研究グループ(TCCSG)ALL委員会
日本小児血液学会雑誌, 19, 5, 355, 355, 日本小児血液学会, Oct. 2005
Japanese

CD10陽性T細胞型急性リンパ性白血病(T-ALL)の臨床像および予後　　　　　　　　　　　　　　　
三浦 信之, 真部 淳, 嶋田 博之, 熊谷 昌明, 金子 隆, 前田 美穂, 木下 明俊, 沖本 由理, 加藤 陽子, 上條 岳彦, 豊田 恭徳, 生田 孝一郎, 小原 明, 花田 良二, 土田 昌宏, 東京小児がん研究グループALL委員会
日本小児血液学会雑誌, 19, 5, 500, 500, 日本小児血液学会, Oct. 2005
Japanese

131I-MIBG療法を2回施行し,良好なQOLを得られた再発神経芽腫の1例　　　　　　　　　　　　　　　
神谷 尚宏, 青山 千晶, 藤田 真智子, 伊藤 雄伍, 今村 壽宏, 加藤 格, 真部 淳, 小川 千登世, 小澤 美和, 細谷 亮太, 横山 邦彦
日本小児血液学会雑誌, 19, 5, 331, 331, 日本小児血液学会, Oct. 2005
Japanese

No advantage of dexamethasone over prednisolone for the outcome of standard- and intermediate-risk childhood acute lymphoblastic leukemia in the Tokyo Children's Cancer Study Group L95-14 protocol
S Igarashi, A Manabe, A Ohara, M Kumagai, T Saito, Y Okimoto, T Kamijo, K Isoyama, M Kajiwara, M Sotomatsu, K Sugita, K Sugita, M Maeda, H Yabe, A Kinoshita, T Kaneko, Y Hayashi, K Ikuta, R Hanada, M Tsuchida
JOURNAL OF CLINICAL ONCOLOGY, 23, 27, 6489, 6498, Sep. 2005, [Peer-reviewed]
English, Scientific journal

若年性骨髄単球性白血病(JMML)における赤芽球コロニー形成に対するビスフォスフォネート製剤の効果　　　　　　　　　　　　　　　
大塚 欣敏, 浅野 由美, 金田 由美, 竹田 洋樹, 森田 直子, 長谷川 大輔, 河崎 裕英, 真部 淳, 辻 浩一郎, 谷澤 隆邦
日本血液学会・日本臨床血液学会総会プログラム・抄録集, 67回・47回, 824, 824, 日本臨床血液学会, Sep. 2005
Japanese

小児急性リンパ性白血病(ALL)診断時・寛解導入期にみられる凝固異常と治療の必要性　　　　　　　　　　　　　　　
加藤 格, 神谷 尚宏, 田草川 彩子, 高橋 宏佳, 小澤 美和, 森本 克, 小川 千登世, 真部 淳, 細谷 亮太
日本血液学会・日本臨床血液学会総会プログラム・抄録集, 67回・47回, 750, 750, 日本臨床血液学会, Sep. 2005
Japanese

海外で処方された睡眠薬により中毒症状を来した1例　　　　　　　　　　　　　　　
今村 壽宏, 伊藤 雄伍, 加藤 格, 神谷 尚宏, 青山 千晶, 藤田 真智子, 安西 有紀, 稲井 郁子, 小澤 美和, 森本 克, 真部 淳, 草川 功, 細谷 亮太
日本小児科学会雑誌, 109, 7, 901, 901, (公社)日本小児科学会, Jul. 2005
Japanese

脾臓摘出術を行い貧血が改善したCDA Type IIの1例
藤田 真智子, 森本 克, 真部 淳, 小澤 美和, 細谷 亮太
日本小児外科学会雑誌, 41, 4, 712, 712, (一社)日本小児外科学会, Jun. 2005
Japanese

Therapy-related myelodysplastic syndrome in childhood: A retrospective study of 36 patients in Japan
M Tsurusawa, A Manabe, Y Hayashi, Y Akiyama, H Kigasawa, H Inada, Y Noguchi, N Sawai, R Kobayashi, Y Nagatoshi, K Kawakami, S Kojima, T Nakahata
LEUKEMIA RESEARCH, 29, 6, 625, 632, Jun. 2005, [Peer-reviewed]
English, Scientific journal

Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia
D Hasegawa, A Manabe, T Kubota, H Kawasaki, Hirose, I, Y Ohtsuka, T Tsuruta, Y Ebihara, Y Goto, XY Zhao, K Sakashita, K Koike, M Isomura, S Kojima, A Hoshika, K Tsuji, T Nakahata
BRITISH JOURNAL OF HAEMATOLOGY, 128, 6, 805, 812, Mar. 2005, [Peer-reviewed]
English, Scientific journal

非血縁者間同種骨髄移植後の再発に対するドナーリンパ球輸注(DLI)の臨床検討　　　　　　　　　　　　　　　
河崎 裕英, 長谷川 大輔, 大塚 欣敏, 鶴田 敏久, 真部 淳, 海老原 康博, 辻 浩一郎
日本小児科学会雑誌, 109, 2, 132, 132, (公社)日本小児科学会, Feb. 2005
Japanese

V-15 Liver hanging maneuver; 切除困難な肝芽腫への適応とその有用性
荒木 夕宇子, 松藤 凡, 堀田 亮, 細谷 亮太, 草川 功, 真部 淳, 青山 千晶, 藤田 真智子
日本小児外科学会雑誌, 41, 3, 416, 416, 特定非営利活動法人 日本小児外科学会, 2005
Japanese

フィラデルフィア染色体陽性急性リンパ性白血病(Ph+ALL)の治療 TCCSG L99-15　　　　　　　　　　　　　　　
真部 淳, 河崎 裕英, 矢部 普正, 小原 明, 高橋 浩之, 生田 孝一郎, 齋藤 友博, 土田 昌宏
小児がん, 41, 3, 558, 558, (NPO)日本小児がん学会, Nov. 2004
Japanese

非血縁者間同種骨髄移植後の再発に対してドナーリンパ球輸注(DLI)を行った3例　　　　　　　　　　　　　　　
河崎 裕英, 長谷川 大輔, 大塚 欣敏, 海老原 康博, 鶴田 敏久, 真部 淳, 辻 浩一郎
小児がん, 41, 3, 705, 705, (NPO)日本小児がん学会, Nov. 2004
Japanese

初診ALLにおけるdelayed lumbar puctureの妥当性　　　　　　　　　　　　　　　
康 勝好, 野口 靖, 福島 敬, 富澤 大輔, 太田 節雄, 齋藤 正博, 高橋 裕之, 真部 淳, 小原 明, 生田 孝一郎, 花田 良二, 土田 昌宏, 東京小児がん研究グループ
小児がん, 41, 3, 557, 557, (NPO)日本小児がん学会, Nov. 2004
Japanese

縦隔原発Desmoplastic small round cell tumorの乳児例　　　　　　　　　　　　　　　
青山 千晶, 伊藤 雄伍, 今村 壽宏, 加藤 格, 神谷 尚宏, 藤田 真智子, 小澤 美和, 森本 克, 真部 淳, 細谷 亮太, 松藤 凡, 鈴木 高祐
小児がん, 41, 3, 631, 631, (NPO)日本小児がん学会, Nov. 2004
Japanese

急性リンパ性白血病治療中腸重積を機に悪性リンパ腫が発見された5歳男児例　　　　　　　　　　　　　　　
加藤 格, 伊藤 雄伍, 今村 壽宏, 神谷 尚宏, 青山 千晶, 藤田 真智子, 小澤 美和, 森本 克, 真部 淳, 細谷 亮太, 清川 信敬, 藤本 純一郎
小児がん, 41, 3, 727, 727, (NPO)日本小児がん学会, Nov. 2004
Japanese

Viral infections in juvenile myelomonocytic leukemia: Prevalence and clinical implications
A Manabe, T Yoshimasu, Y Ebihara, H Yagasaki, M Wada, K Ishikawa, J Hara, K Koike, H Moritake, YD Park, K Tsuji, T Nakahata
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 26, 10, 636, 641, Oct. 2004, [Peer-reviewed]
English, Scientific journal

Viral infections in juvenile myelomonocytic leukemia: Prevalence and clinical implications
A Manabe, T Yoshimasu, Y Ebihara, H Yagasaki, M Wada, K Ishikawa, J Hara, K Koike, H Moritake, YD Park, K Tsuji, T Nakahata
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 26, 10, 636, 641, Oct. 2004, [Peer-reviewed]
English, Scientific journal

若年性骨髄単球性白血病(JMML)におけるビスフォスフォネート製剤の検討　　　　　　　　　　　　　　　
大塚 欣敏, 真部 淳, 長谷川 大輔, 河崎 裕英, 辻 浩一郎
日本血液学会・日本臨床血液学会総会プログラム・抄録集, 66回・46回, 951, 951, 日本臨床血液学会, Sep. 2004
Japanese

有害事象によりL-asparaginase投与を中止した小児急性リンパ性白血病症例の予後　　　　　　　　　　　　　　　
小川 千登世, 生田 孝一郎, 高橋 浩之, 梶原 道子, 前田 美穂, 杉田 憲一, 康 勝好, 菊地 陽, 磯山 恵一, 野口 靖, 矢部 普正, 豊田 恭徳, 真部 淳, 小原 明, 花田 良二, 土田 昌宏, 東京小児がん研究グループALL委員会
日本血液学会・日本臨床血液学会総会プログラム・抄録集, 66回・46回, 751, 751, 日本臨床血液学会, Sep. 2004
Japanese

小児の低2倍体急性リンパ性白血病(ALL)68例の検討　　　　　　　　　　　　　　　
福島 敬, 康 勝好, 高橋 浩之, 真部 淳, 小原 明, 竹 泰秀, 外松 学, 金子 隆, 上條 岳彦, 磯山 恵一, 木下 明俊, 後藤 裕明, 豊田 恭徳, 前田 美穂, 嶋田 博之, 杉田 憲一, 齋藤 正博, 杉田 完爾, 梶原 道子, 矢部 晋正, 菊地 陽, 中舘 尚也, 野口 靖, 牧本 敦, 柳沢 隆昭, 生田 孝一郎, 花田 良二, 土田 昌宏, 東京小児がん研究グループ
日本血液学会・日本臨床血液学会総会プログラム・抄録集, 66回・46回, 752, 752, 日本臨床血液学会, Sep. 2004
Japanese

フィラデルフィア染色体陽性急性リンパ性白血病(Ph+ALL)の治療 TCCSG L99-15　　　　　　　　　　　　　　　
真部 淳, 河崎 裕英, 矢部 普正, 小原 明, 高橋 浩之, 生田 孝一郎, 齋藤 友博, 土田 昌宏
日本小児血液学会雑誌, 18, 4, 301, 301, 日本小児血液学会, Aug. 2004
Japanese

非血縁者間同種骨髄移植後の再発に対してドナーリンパ球輸注(DLI)を行った3例　　　　　　　　　　　　　　　
河崎 裕英, 長谷川 大輔, 大塚 欣敏, 海老原 康博, 鶴田 敏久, 真部 淳, 辻 浩一郎
日本小児血液学会雑誌, 18, 4, 444, 444, 日本小児血液学会, Aug. 2004
Japanese

初診ALLにおけるdelayed lumbar puctureの妥当性　　　　　　　　　　　　　　　
康 勝好, 野口 靖, 福島 敬, 富澤 大輔, 太田 節雄, 齋藤 正博, 高橋 裕之, 真部 淳, 小原 明, 生田 孝一郎, 花田 良二, 土田 昌宏, 東京小児がん研究グループ
日本小児血液学会雑誌, 18, 4, 300, 300, 日本小児血液学会, Aug. 2004
Japanese

縦隔原発Desmoplastic small round cell tumorの乳児例　　　　　　　　　　　　　　　
青山 千晶, 伊藤 雄伍, 今村 壽宏, 加藤 格, 神谷 尚宏, 藤田 真智子, 小澤 美和, 森本 克, 真部 淳, 細谷 亮太, 松藤 凡
日本小児血液学会雑誌, 18, 4, 370, 370, 日本小児血液学会, Aug. 2004
Japanese

急性リンパ性白血病治療中腸重積を機に悪性リンパ腫が発見された5歳男児例　　　　　　　　　　　　　　　
加藤 格, 伊藤 雄伍, 今村 壽宏, 神谷 尚宏, 青山 千晶, 藤田 真智子, 小澤 美和, 森本 克, 真部 淳, 細谷 亮太, 清川 信敬
日本小児血液学会雑誌, 18, 4, 466, 466, 日本小児血液学会, Aug. 2004
Japanese

神経芽腫に対する遺伝子治療(第I相臨床試験)の問題点　　　　　　　　　　　　　　　
大塚 欣敏, 長谷川 大輔, 鶴田 敏久, 河崎 裕英, 海老原 康博, 広瀬 偉美子, 真部 淳, 辻 浩一郎, 黒田 達夫, 佐藤 雄也, 谷澤 昭彦, 山下 直秀
小児がん, 40, 3, 448, 448, (NPO)日本小児がん学会, Nov. 2003
Japanese

Myelodysplastic Syndrome : MDS
MANABE Atsushi
J.J.P.H., 17, 5, 429, 432, THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY, 30 Oct. 2003
Japanese

AMLI/RUNXI mutations are infrequent, but related to AML-M0, acquired trisomy 21, and leukemic transformation in pediatric hematologic malignancies
T Taketani, T Taki, J Takita, M Tsuchida, R Hanada, T Hongo, T Kaneko, A Manabe, K Ida, Y Hayashi
GENES CHROMOSOMES & CANCER, 38, 1, 1, 7, Sep. 2003, [Peer-reviewed]
English, Scientific journal

ALLに対するVP-16を含まないレジメンによる化学療法後に発症したtopoisomerase II阻害剤関連性急性骨髄性白血病　　　　　　　　　　　　　　　
長谷川 大輔, 真部 淳, 大塚 欣敏, 鶴田 敏久, 河崎 裕英, 海老原 康博, 辻 浩一郎, 前田 美穂
臨床血液, 44, 9, 975, 975, (一社)日本血液学会-東京事務局, Sep. 2003
Japanese

CD7/CD13陽性急性白血病の1例　　　　　　　　　　　　　　　
長谷川 大輔, 真部 淳, 鶴田 敏久, 大塚 欣敏, 海老原 康博, 河崎 裕英, 有瀧 健太郎, 松浦 恵子, 辻 浩一郎
日本小児血液学会雑誌, 17, 4, 263, 263, 日本小児血液学会, Aug. 2003
Japanese

DIC,高カルシウム血症を合併した(17;19)番転座を伴った急性リンパ性白血病の1例　　　　　　　　　　　　　　　
大塚 欣敏, 長谷川 大輔, 鶴田 敏久, 河崎 裕英, 海老原 康博, 真部 淳, 杉田 記代子, 田中 葉子, 稲葉 俊哉, 本郷 輝明, 辻 浩一郎
日本小児血液学会雑誌, 17, 4, 283, 283, 日本小児血液学会, Aug. 2003
Japanese

Successful treatment of natural killer (NK) cell leukemia following a long-standing chronic active Epstein-Barr virus (CAEBV) infection with allogeneic bone marrow transplantation
Y Ebihara, A Manabe, R Tanaka, T Yoshimasu, K Ishikawa, T Iseki, J Hayakawa, M Maeda, S Asano, K Tsuji
BONE MARROW TRANSPLANTATION, 31, 12, 1169, 1171, Jun. 2003, [Peer-reviewed]
English, Scientific journal

Effects of sodium in hydration solution on plasma methotrexate concentrations following high-dose methotrexate in children with acute lymphoblastic leukemia
A Kinoshita, Y Kurosawa, K Kondoh, T Suzuki, A Manabe, T Inukai, K Sugita, S Nakazawa
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 51, 3, 256, 260, Mar. 2003, [Peer-reviewed]
English, Scientific journal

Third International Symposium on Myelodysplastic Syndromes in Childhood
Atsushi Manabe, Yoshitoshi Ohtsuka
International Journal of Hematology, 78, 5, 475, 476, Springer Tokyo, 2003, [Peer-reviewed]
English, International conference proceedings

Reconstitution of human haematopoiesis in non-obese diabetic/severe combined immunodeficient mice by clonal cells expanded from single CD34(+) CD38(-) cells expressing Flk2/Flt3
Y Ebihara, M Wada, T Ueda, MJ Xu, A Manabe, R Tanaka, M Ito, H Mugishima, S Asano, T Nakahata, K Tsuji
BRITISH JOURNAL OF HAEMATOLOGY, 119, 2, 525, 534, Nov. 2002, [Peer-reviewed]
English, Scientific journal

短期決戦型TCCSG ALL L92-13再発例の救済とQOLについて　　　　　　　　　　　　　　　
杉田 憲一, 土田 昌宏, 生田 孝一郎, 花田 良二, 金子 隆, 小池 和俊, 角南 勝介, 矢部 みはる, 菊地 陽, 木下 俊明, 渋谷 温, 藤田 宏夫, 高山 順, 外松 学, 加藤 陽子, 森本 克, 沖本 由理, 豊田 恭徳, 小森 功夫, 前田 美穂, 真部 淳, 斉藤 友博, 中澤 眞平, 東京小児がん研究グループ
臨床血液, 43, 8, 327, 327, (一社)日本血液学会-東京事務局, Aug. 2002
Japanese

溶血性貧血,血小板減少にて発症したALPSの一例　　　　　　　　　　　　　　　
稲井 郁子, 森本 克, 小澤 美和, 真部 淳, 金兼 弘和, 宮脇 利男, 三輪 操子, 細谷 亮太
日本小児血液学会雑誌, 16, 4, 267, 267, 日本小児血液学会, Aug. 2002
Japanese

Successful treatment of relapsed blastic natural killer cell lymphoma with unrelated cord blood transplantation
T Yoshimasu, A Manabe, R Tanaka, S Mochizuki, Y Ebihara, K Ishikawa, T Iseki, N Oyaizu, K Aritaki, K Tanaka, T Tsuruta, A Hoshika, S Asano, K Tsuji
BONE MARROW TRANSPLANTATION, 30, 1, 41, 44, Jul. 2002, [Peer-reviewed]
English, Scientific journal

Generation of definitive hematopoietic stem cells from murine early yolk sac and paraaortic splanchnopleures by aorta-gonad-mesonephros region-derived stromal cells
S Matsuoka, K Tsuji, H Hisakawa, MJ Xu, Y Ebihara, T Ishii, D Sugiyama, A Manabe, R Tanaka, Y Ikeda, S Asano, T Nakahata
BLOOD, 98, 1, 6, 12, Jul. 2001, [Peer-reviewed]
English, Scientific journal

Surfactant protein D and KL-6 as serologic indicators of Pneumocystis carinii pneumonia in a child with acute lymphoblastic leukemia
Takashi Takahashi, Yasuhiro Ebihara, Atsushi Manabe, Kohichiro Tsuji, Tetsuya Nakamura, Tatsutoshi Nakahata, Aikichi Iwamoto
Journal of Medicine, 32, 1-2, 41, 51, 2001, [Peer-reviewed]
English, Scientific journal

C67 進行神経芽腫に対する樹状細胞を用いた免疫療法の基礎的研究
中原 さおり, 真部 淳, 浅野 茂隆, 辻 浩一郎, 橋都 浩平
日本小児外科学会雑誌, 36, 3, 250, 250, 特定非営利活動法人 日本小児外科学会, 2000
Japanese

Second international symposium on myelodysplastic syndromes in childhood
Atsushi Manabe
International Journal of Hematology, 72, 4, 522, 524, 2000, [Peer-reviewed]
English, Scientific journal

ヒト臍帯血CD34陽性細胞におけるFlk2/Flt3の発現　　　　　　　　　　　　　　　
海老原 康博, 植田 高弘, 吉野 浩, 石井 武文, 谷ヶ崎 博, 久川 浩章, 三井 哲夫, 郡司 勇治, 田中 竜平, 真部 淳
臨床血液, 40, 9, 921, 921, (一社)日本血液学会-東京事務局, Sep. 1999
Japanese

治療後期のL-アスパラギナーゼにより重症膵炎を発症したALLの1女児例　　　　　　　　　　　　　　　
石井 武文, 真部 淳, 海老原 康博, 植田 高弘, 吉野 浩, 三井 哲夫, 久川 浩章, 谷ヶ崎 博, 菊地 陽, 辻 浩一郎
日本小児血液学会雑誌, 13, 4, 261, 261, 日本小児血液学会, Aug. 1999
Japanese

再生不良性貧血と骨髄異形成症候群の境界例と考えられた1例　　　　　　　　　　　　　　　
吉野 浩, 植田 高弘, 真部 淳, 菊地 陽, 海老原 康博, 三井 哲夫, 久川 浩章, 石井 武文, 谷ヶ崎 博, 辻 浩一郎
日本小児血液学会雑誌, 13, 4, 320, 320, 日本小児血液学会, Aug. 1999
Japanese

再発急性骨髄性白血病患児にみられたNeutropenic enterocolitis(Typhlitis)の1例　　　　　　　　　　　　　　　
吉野 浩, 真部 淳, 海老原 康博, 植田 高弘, 石井 武文, 江口 直宏, 三井 哲夫, 久川 浩章, 谷ヶ崎 博, 菊地 陽
日本小児科学会雑誌, 103, 4, 478, 479, (公社)日本小児科学会, Apr. 1999
Japanese

Fifth international symposium on myelodysplastic syndromes
Atsushi Manabe
International Journal of Hematology, 70, 4, 296, 300, 1999, [Peer-reviewed]
English, Scientific journal

ステロイドが奏効した同種骨髄移植後Bronchiolitis Obliterans Organizing Pneumonia(BOOP)の一例　　　　　　　　　　　　　　　
石井 武文, 真部 淳, 海老原 康博, 植田 高弘, 吉野 浩, 江口 直宏, 三井 哲夫, 久川 浩章, 谷ヶ崎 博, 菊地 陽
日本小児血液学会雑誌, 12, 4, 221, 221, 日本小児血液学会, Aug. 1998
Japanese

Hydroxyureaで芽球のコントロールを行い,非血縁者間骨髄移植(uBMT)を施行した再発急性骨髄性白血病の一例　　　　　　　　　　　　　　　
吉野 浩, 真部 淳, 海老原 康博, 植田 高弘, 石井 武文, 江口 直宏, 三井 哲夫, 久川 浩章, 谷ヶ崎 博, 菊地 陽
日本小児血液学会雑誌, 12, 4, 231, 231, 日本小児血液学会, Aug. 1998
Japanese

Ph1 ALL症例の造血幹細胞移植における多分割高線量の全身照射(TBI)の試み　　　　　　　　　　　　　　　
菊地 陽, 海老原 康博, 植田 高弘, 吉野 浩, 石井 武文, 江口 直宏, 三井 哲夫, 久川 浩章, 谷ヶ崎 博, 真部 淳
日本小児血液学会雑誌, 12, 4, 227, 227, 日本小児血液学会, Aug. 1998
Japanese

G-CSF投与中に脳梗塞をきたしたT-ALLの1例
小澤 美和, 真部 淳, 海老原 康博
日本小児血液学会雑誌, 11, 6, 436, 440, 日本小児血液学会, Dec. 1997
Japanese

Etiologic correlation between streptococcal infection and anaphylactoid purpura....a study of anaphylactoid purpura in recent 10 years in St. Luke's International Hospital.
折居建治, 大矢達男, 大山栄作, 平田倫生, 斎藤昭彦, 海老原康博, 渡部玉蘭, 真部淳, 西村昂三
聖路加健康科学誌, 4/5(1994/1995), 30, 34, Jul. 1997
Japanese

A Case of Acute Lymphoblastic Leukemia Showing Markedly Increased Uptake in the Bone without Uptake in the Liver by ^<67> Ga Scintigraphy
ORII Kenji, MANABE Atsushi, HIRATA Michio, EBIHARA Yasuhiro, WATANABE Gokuran, NISHIMURA Kozo, HOSOYA Ryota
日本小児血液学会雑誌, 11, 2, 120, 124, 日本小児血液学会, 30 Apr. 1997
Japanese

Human B-cell progenitors and bone marrow microenvironment.　　　　　　　　　　　　　　　
Campana D, Coustan-Smith E, Manabe A, Kumagai M, Murti KG, Silvennoinen O, Nishigaki H, Kitanaka A, Ito C
Human cell, 9, 4, 317, 322, Dec. 1996, [Peer-reviewed]

52. 先天性神経芽腫 (NB) stage III の1例(第30回日本小児外科学会関東甲信越地方会)
加地 展之, 松藤 凡, 真部 淳, 細谷 亮太, 横山 穣太郎
日本小児外科学会雑誌, 32, 7, 1161, 1161, 特定非営利活動法人 日本小児外科学会, 1996
Japanese

26 神経芽腫の年齢とステージ別の治療方法と成績(乳児例(非MS)、進行例の手術はどうあるべきか, V.神経芽腫, 第11回日本小児外科学会秋季シンポジウム)
松藤 凡, 細谷 亮太, 真部 淳, 横山 穣太郎
日本小児外科学会雑誌, 31, 6, 871, 871, 特定非営利活動法人 日本小児外科学会, 1995
Japanese

63. 多発皮下転移を認めた小円形細胞肉腫の1例(第29回関東甲信越地方会)
澤村 聡美, 松藤 凡, 細谷 亮太, 真部 淳, 植草 利公, 横山 譲太郎, 秦 順一
日本小児外科学会雑誌, 31, 1, 127, 127, 特定非営利活動法人 日本小児外科学会, 1995
Japanese

Effects of Atrial Natriuretic Peptide on Hepatic Tissue Blood Flow in Rats
MANABE Atsushi
JOURNAL OF THE KYORIN MEDICAL SOCIETY, 21, 4, 477, 486, The Kyorin Medical Society, 1990
Japanese, Effects of intra-arterial injection of rat-atrial natriuretic peptide on hepatic tissue blood flow (HTBF) and mean blood pressure (MBP) were evaluated in normal and cirrhotic rats. HTBF was measured by the electrolytic hydrogen clearance method at, 0, 1, 10 and 20 min after bolus injection of ANP into the femoral artery. In normal rats, no significant changes was observed after injection of 10, 100 and 1000 μg/kg of ANP on HTBF. However, MBP fell significantly for 20 min after injection of 1000 μg/kg of ANP, while no significant change was observed with 10, or 100 μg/kg of ANP. In cirrhotic rats, HTBF increased by 20 % at 1 min after injection of 100 μg/kg of ANP (p<0.05), whereas it decreased by 17 % at 1 min after injection of 1000 μg/kg of ANP. No significant change was observed with 10 μg/kg of ANP. MBP fell significantly at 1 min after injection of 100 μg/kg of ANP and 20 min after injection of 1000 μg/kg of ANP respectively (p<0.01, p<0.01), while no significant change was observed with 10 μg/kg of ANP. These results indicate that the effect of ANP on HTBF is more prominent in cirrhotic than normal rats, and that the injection of ANP in a case of optimal dose induces an increase of HTBF in cirrhotic rats. Concerning THBF, ANP may be benefit in the therapy of patients with cirrhosis.

I-E-41 小児急性リンパ性白血症同胞発生のみられた2家族における両親の心理的反応(腫瘍・死の臨床)(一般口演)
細谷 亮太, 真部 淳, 岩堀 晃, 西村 昂三
心身医学, 28, 108, 108, 一般社団法人 日本心身医学会, 1988
Japanese

PHOTOIMMUNOTHERAPY USING ANTI-GD2 ANTIBODY FOR NEUROBLASTOMA AND OSTEOSARCOMA
Jimei Zhao, Masahiro Ueki, Kohei Nakajima, Yukayo Terashita, Shinsuke Hirabayashi, Yuko Cho, Mikako Ogawa, Atsushi Manabe, PEDIATRIC BLOOD & CANCER, 71, S5, S5, Jan. 2024
English, Summary international conference

IS DOSE MODIFICATION OF 6-MERCAPTOPURINE NECESSARY FOR PATIENTS WITH NUDT15 VARIANT IN EARLY INTENSIFICATION THERAPY FOR CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA?
Jimei Zhao, Masahiro Ueki, Saori Sawai, Minako Sugiyama, Yukayo Terashita, Shinsuke Hirabayashi, Yuko Cho, Ryoji Kobayashi, Yoichi Tanaka, Atsushi Manabe, PEDIATRIC BLOOD & CANCER, 71, S103, S103, Jan. 2024
English, Summary international conference

Treatment of intracranial immature teratoma with serum AFP elevation
山口秀, 伊師雪友, 大木聡悟, 茂木洋晃, 長谷河昌孝, 寺下友佳代, 平林真介, 西岡健太郎, 橋本孝之, 真部淳, 藤村幹, 小児の脳神経(Web), 49, 2, 2024

Report of Comprehensive Genomic Profiling (CGP) for the Patients with Primary Brain Tumors in Hokkaido Univ. Hospital
山口秀, 茂木洋晃, 澤谷亮佑, 伊師雪友, 寺下友佳代, 平林真介, 杉山未奈子, 齋藤祐介, 木下一郎, 真部淳, 藤村幹, 日本脳腫瘍学会学術集会プログラム・抄録集, 41st, 2023

IMMUNOPHENOTYPIC AND CHROMOSOMAL CHARACTERIZATION OF KMT2A GERMLINE ACUTE LYMPHOBLASTIC LEUKEMIA IN INFANTS
Hiroki Yoshihara, Takako Miyamura, Takao Deguchi, Toshinori Hori, Tomohiko Taki, Kunihiko Moriya, Yuki Arakawa, Mariko Eguchi, Kunihiro Shinoda, Yuhki Koga, Katsuyoshi Koh, Atsushi Manabe, Keizo Horibe, Daisuke Tomizawa, PEDIATRIC BLOOD & CANCER, 69, Nov. 2022
English, Summary international conference

乳児へのボリコナゾール投与中に、代謝機能の発達によると考えられる著しい血中濃度低下が認められた1例
山口 敦史, 田澤 佑基, 武隈 洋, 植木 将弘, 山田 雅文, 真部 淳, 菅原 満, TDM研究, 39, 2, 136, 136, May 2022
(一社)日本TDM学会, Japanese

早産出生の乳幼児の睡眠と精神発達　　　　　　　　　　　　　　　
太田 英伸, 安藤 明子, 吉村 優子, 中川 真智子, 安積 陽子, 中澤 貴代, 三谷 裕介, 大石 芳久, 水島 正人, 安達 裕行, 兼次 洋介, 森岡 圭太, 島袋 林秀, 平田 倫生, 池田 尊司, 福冨 理佳, 小林 京子, 小澤 美和, 竹島 正浩, 真部 淳, 高橋 勉, 三島 和夫, 草川 功, 與田 仁志, 菊知 充, 長 和俊, 精神神経学雑誌, 124, 4付録, S, 517, Apr. 2022
(公社)日本精神神経学会, Japanese

How should we manage multiple intracerebral hemorrhage and brain death in a patient with T-ALL?
長祐子, 澤井彩織, 原和也, 寺下友佳代, 杉山未奈子, 平林真介, 真部淳, 杉山拓, 方波見謙一, 浜崎和朗, 日本小児科学会雑誌, 126, 2, 2022

Heterozygous NUDT15 Gene Polymorphism Would Not Associate with the Severity of 6-Mercaptopurine Side Effects in Early Intensification Therapy for Childhood Acute Lymphoblastic Leukemia
Jimei Zhao, Masahiro Ueki, Saori Sawai, Minako Sugiyama, Yukayo Terashita, Shinsuke Hirabayashi, Yuko Cho, Yoichi Tanaka, Atsushi Manabe, BLOOD, 138, 23 Nov. 2021
English, Summary international conference

Chemotherapy with the Use of TKIs Based on MRD Has the Potential to Avoid Hematopoietic Stem Cell Transplantation in Treatment for Children with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph plus ALL). Results of the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) Study ALL-Ph13
Atsushi Sato, Hirohide Kawasaki, Takao Deguchi, Yoshiko Hashii, Yuka Iijima-Yamashita, Sachiko Yonezawa, Chiyo K. Imamura, Haruko Shima, Hirotoshi Sakaguchi, Yuichi Kodama, Keisuke Kato, Motohiro Kato, Hidefumi Hiramatsu, Nobutaka Kiyokawa, Akiko Kada, Akiko M. Saito, Keizo Horibe, Atsushi Manabe, Hiroyuki Shimada, BLOOD, 138, Nov. 2021
English, Summary international conference

新規の白血病特性を有するmyeloid/natural killer cell precursor acute leukemia(Myeloid/natural killer(NK) cell precursor acute leukemia as a novel distinctive leukemia entity)　　　　　　　　　　　　　　　
西村 聡, 横山 和明, 成戸 卓也, 中園 博仁, 木村 俊介, 今村 俊彦, 森尾 友宏, 金井 昭教, 松井 啓隆, 梅田 雄嗣, 佐野 秀樹, 小池 隆志, 頼 晋也, 關中 悠仁, 小川 淳, 木下 明俊, 柴 徳生, 三木 瑞香, 木村 文彦, 中山 秀樹, 中沢 洋三, 多賀 崇, 滝 智彦, 足立 壯一, 真部 淳, 康 勝好, 石田 也寸志, 滝田 順子, 東條 有伸, 高木 正稔, 日本血液学会学術集会, 83回, PL, 4, Sep. 2021
(一社)日本血液学会, English

Comprehensive Genetic Analysis Revealed Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia As a Novel Distinctive Leukemia Entity
Akira Nishimura, Kazuaki Yokoyama, Chika Yamagishi, Toshihiko Imamura, Takuya Naruto, Tomohiro Morio, Yukie Tanaka, Akinori Kanai, Hirotaka Matsui, Naoko Higuchi, Akiko Takada, Haruna Okuno, Shoji Saito, Shuhei Karakawa, Shogo Kobayashi, Daisuke Hasegawa, Hiroyuki Fujisaki, Daiichiro Hasegawa, Kazutoshi Koike, Takashi Koike, Shinya Rai, Katsutsugu Umeda, Hideki Sano, Yujin Sekinaka, Atsushi Ogawa, Akitoshi Kinoshita, Norio Shiba, Mizuka Miki, Fumihiko Kimura, Hideki Nakayama, Yozo Nakazawa, Takashi Taga, Tomohiko Taki, Souichi Adachi, Atsushi Manabe, Katsuyoshi Koh, Yasushi Ishida, Arinobu Tojo, Masatoshi Takagi, BLOOD, 136, Nov. 2020
English, Summary international conference

小児血液・腫瘍性疾患の治療中にPRESによる非けいれん性てんかん重積を認めた2例　　　　　　　　　　　　　　　
山本 薫, 代田 惇朗, 長谷川 大輔, 木村 俊介, 吉本 優里, 平林 真介, 細谷 要介, 野崎 太希, 横山 美奈, 真部 淳, 荻原 正明, 日本小児科学会雑誌, 124, 9, 1391, 1396, Sep. 2020
(公社)日本小児科学会, Japanese

NUDT15 Variants Confer High Incidence of Secondary Malignancies of ALL in Children
Masanori Yoshida, Kazuhiko Nakabayashi, Aiko Sato-Otsubo, Shinichi Tsujimoto, Kaoru Yoshida, Ryota Shirai, Tomoo Osumi, Yuki Yuza, Masatoshi Takagi, Hiroyuki Takahashi, Katsuyoshi Koh, Akitoshi Kinoshita, Moeko Hino, Toshihiko Imamura, Yozo Nakazawa, Okuya Mayuko, Harumi Kakuda, Masashi Sanada, Kimikazu Matsumoto, Daisuke Tomizawa, Nobutaka Kiyokawa, Akira Ohara, Atsushi Manabe, Kenichiro Hata, Jun J. Yang, Motohiro Kato, BLOOD, 134, Nov. 2019
English, Summary international conference

多彩な自己炎症性疾患を紐解く Linear ubiquitin assembly complexとOTULINによる炎症と細胞死の制御 OTULIN-related autoinflammatory syndrome患者の解析を通して　　　　　　　　　　　　　　　
植木 将弘, 松廣 淳平, 竹崎 俊一郎, 藤田 宏明, 三宅 紀子, 戸澤 雄介, 山田 雅文, 小林 一郎, 松本 直通, 有賀 正, 岩井 一宏, 真部 淳, 日本小児リウマチ学会総会・学術集会プログラム・抄録集, 29回, 52, 52, Oct. 2019
(一社)日本小児リウマチ学会, Japanese

大頭症、軽度運動発達遅滞、白質信号異常を呈し、PTEN遺伝子変異を認めた男児例　　　　　　　　　　　　　　　
黒子 由梨香, 山本 薫, 横山 美奈, 代田 惇朗, 平林 真介, 真部 淳, 荻原 正明, 草川 功, 青木 洋子, 小崎 里華, 脳と発達, 51, Suppl., S359, S359, May 2019
(一社)日本小児神経学会, Japanese

造血細胞移植後に生じた腸管気腫症に対して間欠的酸素投与が有効であった3例
足洗美穂, 西村聡, 西村聡, 神谷尚宏, 山本俊亮, 小野林太郎, 友田昴宏, 山本薫, 井上健斗, 井上真依子, 廣木遥, 宮本智史, 星野顕宏, 梅原直, 平林真介, 岡本健太郎, 柳町昌克, 磯田健志, 細谷要介, 長谷川大輔, 今井耕輔, 高木正稔, 金兼弘和, 森尾智宏, 真部淳, 日本造血細胞移植学会総会プログラム・抄録集, 41st, 2019

A case of neuroblastoma diagnosed by growth failure and hyperhidrosis
橋本 佳帆子, 中山 加奈子, 山口 健史, 原 和也, 寺下 友佳代, 杉山 未奈子, 長 祐子, 井口 晶裕, 本多 昌平, 中村 明枝, 真部 淳, 臨床小児医学 = The Journal of clinical pediatrics, Sapporo, 67, 1, 84, 89, 2019
日本小児科学会北海道地方会, Japanese

Characteristics and Treatment Outcome of Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia not Enrolled on Clinical Trials in TKI-era
Keisuke Kato, Hirotoshi Sakaguchi, Yuichi Kodama, Yuichi Shinkoda, Akira Shimada, Takashi Iwase, Junko Takita, Chitose Ogawa, Hidefumi Hiramatsu, Motohiro Kato, Atsushi Sato, Hideko Uryu, Tsuyako Iwai, Akiko Saito, Hirohide Kawasaki, Katsuyoshi Koh, Atsushi Manabe, Keizo Horibe, Hiroyuki Shimada, PEDIATRIC BLOOD & CANCER, 65, S64, S65, Nov. 2018
English, Summary international conference

Clinical Feature and Genetic Alterations in Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia and Myeloid/NK Cell Acute Leukemia
Akira Nishimura, Kazuaki Yokoyama, Chika Yamagishi, Takuya Naruto, Tomohiro Morio, Akinori Kanai, Hirotaka Matsui, Naoko Higuchi, Akiko Takada, Haruna Okuno, Shoji Saito, Shuhei Karakawa, Shogo Kobayashi, Hideki Sano, Takashi Koike, Daisuke Hasegawa, Hiroyuki Fujisaki, Daiichiro Hasegawa, Kazutoshi Koike, Atsushi Ogawa, Akitoshi Kinoshita, Norio Shiba, Mizuka Miki, Hideki Nakayama, Yozo Nakazawa, Toshihiko Imamura, Takashi Taga, Souichi Adachi, Katsuyoshi Koh, Atsushi Manabe, Tomohiko Taki, Yasushi Ishida, Arinobu Tojo, Masatoshi Takagi, BLOOD, 132, Nov. 2018
English, Summary international conference

DNA Methylation-Based Characterization of T-cell Acute Lymphoblastic Leukemia Well Correlated with Genetic Features, Prognosis and Differentiation Stages
Shunsuke Kimura, Masafumi Seki, Tomoko Kawai, Kenichi Yoshida, Tomoya Isobe, Hiroo Ueno, Yusuke Shiozawa, Hiromichi Suzuki, Yuichi Shiraishi, Kentaro Ohki, Motohiro Kato, Katsuyoshi Koh, Ryoji Kobayashi, Takao Deguchi, Yoshiko Hashii, Toshihiko Imamura, Atsushi Sato, Nobutaka Kiyokawa, Atsushi Manabe, Masashi Sanada, Akira Ohara, Keizo Horibe, Masao Kobayashi, Akira Oka, Yasuhide Hayashi, Satoru Miyano, Kenichiro Hata, Seishi Ogawa, Junko Takita, PEDIATRIC BLOOD & CANCER, 65, S21, S22, Nov. 2018
English, Summary international conference

The Prognostic Value of TP53 Mutations Depends on Clinical Backgrounds in Pediatric Patients with Acute Lymphoblastic Leukemia
Hiroo Ueno, Kenichi Yoshida, Yusuke Shiozawa, Yasuhito Nannya, Yuka Iijima-Yamashita, Nobutaka Kiyokawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Tomoya Isobe, Masafumi Seki, Shunsuke Kimura, Hideki Makishima, Nobuyuki Kakiuchi, Keisuke Kataoka, Tetsuichi Yoshizato, Hiroyuki Tsukamoto, Dai Nishijima, Takao Deguchi, Kentaro Ohki, Atsushi Sato, Hiroyuki Takahashi, Yoshiko Hashii, Sadao Tokimasa, Junichi Hara, Yoshiyuki Kosaka, Koji Kato, Takeshi Inukai, Junko Takita, Toshihiko Imamura, Satoru Miyano, Atsushi Manabe, Keizo Horibe, Seishi Ogawa, Masashi Sanada, BLOOD, 132, Nov. 2018
English, Summary international conference

Tolerable Dose of 6-Mercaptopurine and Prognostic Impact of NUDT15-Deficient Genotype in Childhood Acute Lymphoblastic Leukemia
Yoichi Tanaka, Motohiro Kato, Takaya Moriyama, Yuki Arakawa, Daisuke Hasegawa, Junya Fujimura, Dai Keino, Atsushi Sato, Takahiro Ueda, Yuichi Taneyama, Masatoshi Takagi, Masaki Yamamoto, Masaki Matsuoka, Moeko Hino, Hiroki Hori, Katsuyoshi Koh, Allen Eng Juh Yeoh, Jun J. Yang, Atsushi Manabe, BLOOD, 132, Nov. 2018
English, Summary international conference

Dasatinib-Combined Less Intensive Chemotherapy for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia in Down Syndrome
Hirabayashi Shinsuke, Yamamoto Shunsuke, Yamamoto Kaoru, Yamamoto Kazuki, Aiga Saori, Daida Atsuro, Ono Rintaro, Ashiarai Miho, Nishimura Akira, Hosoya Yosuke, Hasegawa Daisuke, Manabe Atsushi, PEDIATRIC BLOOD & CANCER, 65, S97, Nov. 2018, [Peer-reviewed]

Successful Inhaled Nitric Oxide Therapy for Severe Acute Respiratory Failure Due to Alveolar Hemorrhage During Induction Phase in AML M5
Ashiarai Miho, Umehara Naoki, Kuroko Yurika, Yamamoto Kaoru, Yamamoto Shunsuke, Ono Rintaro, Hirabayashi Shinsuke, Hosoya Yosuke, Hasegawa Daisuke, Manabe Atsushi, PEDIATRIC BLOOD & CANCER, 65, S55, S56, Nov. 2018, [Peer-reviewed]

小児T細胞性急性リンパ性白血病におけるNOTCH1シグナル活性化変異の種類と臨床的特徴の解析(Analysis of features of alterations leading to activate NOTCH1 signaling in pediatric T-ALL)　　　　　　　　　　　　　　　
木村 俊介, 関 正史, 吉田 健一, 上野 浩生, 塩澤 裕介, 磯部 知弥, 大木 健太郎, 加藤 元博, 康 勝好, 小林 良二, 出口 隆生, 橋井 佳子, 今村 俊彦, 佐藤 篤, 清河 信敬, 真部 淳, 堀部 敬三, 小原 明, 眞田 昌, 小林 正夫, 岡 明, 林 泰秀, 宮野 悟, 小川 誠司, 滝田 順子, 臨床血液, 59, 9, 1585, 1585, Sep. 2018
(一社)日本血液学会-東京事務局, English

小児ALLにおける高用量メトトレキサート療法時の薬物クリアランスへ影響を及ぼす因子の検討(The between MTX clearance and genetic variants in high-dose MTX therapy for ALL)　　　　　　　　　　　　　　　
田中 庸一, 浦山 ケビン, 森 麻希子, 長谷川 大輔, 赤羽 弘資, 太田 節雄, 康 勝好, 真部 淳, 臨床血液, 59, 9, 1533, 1533, Sep. 2018
(一社)日本血液学会-東京事務局, English

Clinical Sequencing of 347 Children with Acquired and Inherited Bone Marrow Failure Syndromes
Hideki Muramatsu, Yusuke Okuno, Kenichi Yoshida, Yuichi Shiraishi, Sayoko Doisaki, Atsushi Narita, Hirotoshi Sakaguchi, Nozomu Kawashima, Xinan Wang, Yinyan Xu, Kenichi Chiba, Hiroko Tanaka, Asahito Hama, Masashi Sanada, Yoshiyuki Takahashi, Hitoshi Kanno, Hiroki Yamaguchi, Shouichi Ohga, Atsushi Manabe, Hideo Harigae, Shinji Kunishima, Eiichi Ishii, Masao Kobayashi, Kenichi Koike, Kenichiro Watanabe, Etsuro Ito, Minoru Takata, Miharu Yabe, Seishi Ogawa, Satoru Miyano, Seiji Kojima, BLOOD, 130, Dec. 2017
English, Summary international conference

Comprehensive Immunophenotyping Panel in Japan Enables to Detect Rare Subtypes in Childhood Leukemia
Takao Deguchi, Nobutaka Kiyokawa, Kentaro Ohki, Yoshiko Hashii, Atsushi Manabe, Souichi Adachi, Akiko Moriya Saito, Keizo Horibe, BLOOD, 130, Dec. 2017
English, Summary international conference

Integrated Genetic and Epigenetic Analysis in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)
S. Kimura, M. Seki, T. Kawai, K. Yoshida, T. Isobe, H. Ueno, H. Suzuki, K. Oki, T. Imamura, N. Kiyokawa, M. Kobayashi, K. Koh, A. Manabe, A. Ohara, M. Sanada, Y. Hayashi, K. Hata, S. Miyano, S. Ogawa, J. Takita, PEDIATRIC BLOOD & CANCER, 64, S31, S31, Nov. 2017
English, Summary international conference

Close Correlation Between Immunophenotype and Genetic Abnormalities in Childhood Acute Lymphoblastic Leukemia: Results from TCCSG Study L04-16
Nobutaka Kiyokawa, Takashi Fukushima, Kentaro Ohki, Motohiro Kato, Takeshi Ishibashi, Ai Yoshimi, Yuya Saito, Takahiro Aoki, Kazuki Terada, Osamu Tomita, Keiko Onda, Yoshihiro Gocho, Shinsuke Hirabayashi, Daisuke Hasegawa, Hiroyuki Takahahsi, Katsuyoshi Koh, Atsushi Manabe, Akira Ohara, PEDIATRIC BLOOD & CANCER, 64, S17, S17, Nov. 2017
English, Summary international conference

Multimodality Treatment for Pelvic Ewing Sarcoma
Akira Nishimura, Ayumu Arakawa, Yosuke Hosoya, Shinsuke Hirabayashi, Hiroki Yoshihara, Atsushi Kikuta, Seiichi Matsumoto, Jiro Kawamori, Daisuke Hasegawa, Tadashi Kumamoto, Chitose Ogawa, Atsushi Manabe, PEDIATRIC BLOOD & CANCER, 64, S58, S58, Nov. 2017
English, Summary international conference

Asymptomatic Cerebral Microhemorrhage in Adolescent and Young Adult Survivors of Childhood Cancer: Five Patients Examined Using Magnetic Resonance Imaging
Yosuke Hosoya, Yasushi Ishida, Miwa Ozawa, Taiki Nozaki, Kyoko Nagase, Michiyo Gunji, Kunie Maeda, Kyoko Kobayashi, Yuri Yoshimoto, Daisuke Hasegawa, Atsushi Manabe, Ryota Hosoya, PEDIATRIC BLOOD & CANCER, 64, S100, S100, Nov. 2017
English, Summary international conference

The Feasibility of a Comprehensive Medical Check-up in Adolescent and Young Adult Survivors of Childhood Cancer
Miwa Ozawa, Yasushi Ishida, Kyoko Kobayashi, Kyoko Nagase, Michiyo Gunzi, Kunie Maeda, Yuri Yoshimoto, Yosuke Hosoya, Daisuke Hasegawa, Atsushi Manabe, Ryota Hosoya, PEDIATRIC BLOOD & CANCER, 64, S101, S101, Nov. 2017
English, Summary international conference

The Association Between Plasma Methotrexate Concentration and Genetic Variant in High-dose Methotrexate Therapy for Childhood Acute Lymphoblastic Leukemia
Yoichi Tanaka, Kevin Urayama, Makiko Mori, Daisuke Hasegawa, Koshi Akahane, Setsuo Ota, Katsuyoshi Koh, Atsushi Manabe, PEDIATRIC BLOOD & CANCER, 64, S97, S98, Nov. 2017
English, Summary international conference

IDH1 and KRAS Mutations are Involved in Acute Lymphoblastic Leukemia in Maffucci Syndrome
S. Hirabayashi, M. Seki, D. Hasegawa, M. Kato, N. Hyakuna, T. Shuo, S. Kimura, K. Yoshida, K. Kataoka, Y. Fujii, Y. Shiraishi, K. Chiba, H. Tanaka, N. Kiyokawa, S. Miyano, S. Ogawa, J. Takita, A. Manabe, PEDIATRIC BLOOD & CANCER, 64, S179, S180, Nov. 2017
English, Summary international conference

Correlation of Bone Marrow Morphology with Clinical Findings and Gene Alterations in Patients with Diamond-Blackfan Anemia
Asahito Hama, Tsutomu Toki, Akie Kobayashi, Hideki Muramatsu, Yusuke Okuno, Daisuke Hasegawa, Kazue Nozawa, Yoshiyuki Takahashi, Kenichiro Watanabe, Atsushi Manabe, Masafumi Ito, Etsuro Ito, Seiji Kojima, PEDIATRIC BLOOD & CANCER, 64, S28, S28, Nov. 2017
English, Summary international conference

Characteristics of Childhood Mixed Phenotype Acute Leukemia Diagnosed By Nation-Wide Immunophenotyping in Japan
Takao Deguchi, Nobutaka Kiyokawa, Kentaro Ohki, Yoshiko Hashii, Atsushi Manabe, Souichi Adachi, Akiko Saito, Keizou Horibe, PEDIATRIC BLOOD & CANCER, 64, S16, S16, Nov. 2017
English, Summary international conference

先天性および後天性造血不全375例に対するクリニカルシーケンス(Clinical sequencing of 375 patients with inherited and acquired bone marrow failure syndromes)
Muramatsu Hideki, Okuno Yusuke, Yoshida Kenichi, Shiraishi Yuichi, Narita Atsushi, Sakaguchi Hirotoshi, Kawashima Nozomu, Xu Yinyan, Chiba Kenichi, Tanaka Hiroko, Hama Asahito, Sanada Masashi, Takahashi Yoshiyuki, Kanno Hitoshi, Yamaguchi Hiroki, Ohga Shouichi, Manabe Atsushi, Harigae Hideo, Kunishima Shinji, Ishii Eiichi, Kobayashi Masao, Koike Kenichi, Watanabe Kenichiro, Ito Etsuro, Takata Minoru, Yabe Miharu, Miyano Satoru, Ogawa Seishi, Kojima Seiji, 臨床血液, 58, 9, 1519, 1519, Sep. 2017
(一社)日本血液学会-東京事務局, English

Congenetal dyserythropoietic anemia 10例の全エクソーム解析結果(Whole exome sequency analysis of congenital dyserythropoietic anemia in Japan)
Hamada Motoharu, Doisaki Sayoko, Okuno Yusuke, Muramatsu Hideki, Hama Asahito, Kataoka Shinsuke, Ichikawa Daisuke, Taniguchi Rieko, Suzuki Kyogo, Kojima Daiei, Sekiya Yuko, Kawashima Nozomu, Narita Atsushi, Yoshida Kenichi, Shiraishi Yuichi, Sanada Masashi, Chiba Kenichi, Tanaka Hiroko, Manabe Atsushi, Taga Takashi, Takahashi Yoshiyuki, Miyano Satoru, Ogawa Seishi, Kojima Seiji, 臨床血液, 58, 9, 1477, 1477, Sep. 2017
(一社)日本血液学会-東京事務局, English

"つつうらうら"の小児救急事情 小児救急医療の現況 多角的な視点から課題を共有する 当院の小児救急医療の10年間の動向 都市部の立場から　　　　　　　　　　　　　　　
梅原 直, 草川 功, 真部 淳, 小澤 美和, 稲井 郁子, 平田 倫生, 吉良 登志子, 山田 奈生子, 塙 佳生, 日原 真理子, 小森 信政, 渡辺 浩志, 小坂 和輝, 松藤 凡, 日本小児救急医学会雑誌, 16, 2, 232, 232, May 2017
(一社)日本小児救急医学会, Japanese

過去10年間に当院外来を受診した、異物・誤飲患児に関する検討　　　　　　　　　　　　　　　
山本 俊亮, 山本 薫, 相賀 咲央莉, 山本 一希, 梅原 直, 島袋 林秀, 平田 倫生, 小澤 美和, 真部 淳, 草川 功, 右田 美里, 松藤 凡, 日本小児救急医学会雑誌, 16, 2, 312, 312, May 2017
(一社)日本小児救急医学会, Japanese

ターゲットシーケンス解析を施行した小児造血不全移植例の解析
村松秀城, 奥野友介, 吉田健一, 白石友一, 濱麻人, 真田昌, 高橋義行, 菅野仁, 山口博樹, 大賀正一, 真部淳, 張替秀郎, 國島伸治, 石井榮一, 小林正夫, 小池健一, 渡邉健一郎, 伊藤悦朗, 高田穣, 矢部みはる, 小川誠司, 宮野悟, 小島勢二, 日本造血細胞移植学会総会プログラム・抄録集, 40th, 2017

特発性造血障害に関する調査研究 先天性造血不全症候群の研究
中畑龍俊, 真部淳, 特発性造血障害に関する調査研究 平成28年度 総括・分担研究報告書(Web), 201610059A0012 (WEB ONLY), 2017
Japanese

Five Cases of Pediatric-Onset Bechet’s disease complicated with Myelodysplastic Syndrome.　　　　　　　　　　　　　　　
Kanamitsu K, Shimada A, Nishiuchi R, Shigemura T, Nakazawa Y, Koike K, Kodama Y, Shinkoda Y, Kawano Y, Yasui K, Sasaki K, Kajiwara R, Tsukahara H, Manabe A, International Journal of Hematology, 105, 3, 377, 382, 2017

TAL1 Super Enhancer Aberration and Stil-TAL1 Fusion in Pediatric T Cell Acute Lymphoblastic Leukemia
Shunsuke Kimura, Masafumi Seki, Kenichi Yoshida, Hiroo Ueno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hiromichi Suzuki, Keisuke Kataoka, Kentaro Ohki, Motohiro Kato, Katsuyoshi Koh, Ryoji Hanada, Nobutaka Kiyokawa, Masao Kobayashi, Atsushi Manabe, Akira Ohara, Yasuhide Hayashi, Satoru Miyano, Seishi Ogawa, Junko Takita, BLOOD, 128, 22, Dec. 2016
English, Summary international conference

Clusters of Childhood Mixed Phenotype Acute Leukemia Diagnosed By Nation-Wide Immunophenotyping in Japan
Takao Deguchi, Nobutaka Kiyokawa, Kentaro Ohki, Yoshiko Hashii, Atsushi Manabe, Souichi Adachi, Akiko M. Saito, Keizo Horibe, Yoshihiro Komada, BLOOD, 128, 22, Dec. 2016
English, Summary international conference

Genetic Abnormalities and Prognosis in Pediatric B-Precursor Acute Lymphoblastic Leukemia without Conventional Genetic Abnormalities; Tokyo Children's Cancer Study Group
Kenro Ohki, Shinsuke Hirabayashi, Akinori Yaguchi, Akinori Yaguchi, Kazuki Terada, Jun Ohkubo, Norio Shiba, Motohiro Kato, Takashi Fukushima, Katsuyoshi Koh, Hayashi Yasuhide, Atsushi Manabe, Akira Ohara, Nobutaka Kiyokawa, BLOOD, 128, 22, Dec. 2016
English, Summary international conference

Comparison of Clinical Outcomes Between Pediatric Aplastic Anemia and Refractory Cytopenia of Childhood
Asahito Hama, Atsushi Manabe, Daisuke Hasegawa, Kazue Nozawa, Atsushi Narita, Hideki Muramatsu, Yoshiyuki Takahashi, Kenichiro Watanabe, Akira Ohara, Masafumi Ito, Seiji Kojima, BLOOD, 128, 22, Dec. 2016
English, Summary international conference

TAL1 Abnormalities in Childhood T-Cell Acute Lymphoblastic Leukemia
M. Seki, K. Yoshida, S. Kimura, Y. Shiraishi, M. Kato, K. Koh, R. Hanada, T. Deguchi, T. Imamura, K. Horibe, N. Kiyokawa, A. Manabe, A. Ohara, M. Sanada, H. Mano, Y. Hayashi, S. Miyano, A. Oka, S. Ogawa, J. Takita, PEDIATRIC BLOOD & CANCER, 63, S117, S117, Nov. 2016
English, Summary international conference

小児造血器腫瘍の分子遺伝学の進歩 : WHO分類第4版2016改訂 (特集 小児造血器腫瘍の特色 : 分子的理解から治療開発まで)
平林 真介, 真部 淳, 血液フロンティア, 26, 11, 1561, 1568, Nov. 2016
医薬ジャーナル社, Japanese

Risk Factors for Psychosomatic Symptoms in Patients with Paediatric Cancers
D. Hasegawa, K. I. Maeda, K. Urayama, S. I. Tsujimoto, Y. Azami, M. Ozawa, A. Manabe, PEDIATRIC BLOOD & CANCER, 63, S280, S281, Nov. 2016
English, Summary international conference

本邦での骨髄浸潤を伴わない小児顆粒球肉腫の後方視的研究(Retrospective study for pediatric myeloid sarcoma without bone marrow involvement in Japan)
多賀 崇, 今村 俊彦, 中島 健太郎, 前田 尚子, 渡辺 輝浩, 宮島 雄二, 藤村 純也, 佐野 仁志, 長谷川 大一郎, 河崎 裕英, 足立 壮一, 高木 正稔, 康 勝好, 真部 淳, 滝 智彦, 石田 也寸志, 日本小児血液・がん学会白血病リンパ腫委員会, 日本小児血液・がん学会雑誌, 53, 4, 251, 251, Nov. 2016
(一社)日本小児血液・がん学会, English

mTOR阻害剤が有効であった血管奇形の3例　　　　　　　　　　　　　　　
平林 真介, 長谷川 大輔, 吉本 優里, 細谷 要介, 熊本 忠史, 真部 淳, 鮫島 麗子, 藤村 純也, 日本小児血液・がん学会雑誌, 53, 4, 282, 282, Nov. 2016
(一社)日本小児血液・がん学会, Japanese

日本人小児ALLのL-アスパラギナーゼアレルギー発現におけるNFATC2 rs6021191多型の影響(Lack of association between L-asparaginase allergy and rs6021191 variant in NFATC2 in Japanese children with acute lymphoblastic leukemia)
田中 庸一, ウラヤマ・ケビン, 森 麻希子, 長谷川 大輔, 石丸 紗恵, 寺田 和樹, 柳町 昌克, 太田 節雄, 高橋 浩之, 外山 大輔, 慶野 大, 森脇 浩一, 高木 正稔, 藤村 純也, 関中 悠仁, 中村 こずえ, 佐藤 雄弥, 小原 明, 康 勝好, 真部 淳, 日本小児血液・がん学会雑誌, 53, 4, 342, 342, Nov. 2016
(一社)日本小児血液・がん学会, English

改訂版長期フォローアップ手帳(Follow Up Diary)の使用感に関する全国調査(A nation-wide survey of usability assessment for the revised version of the "Long-Term Follow Up Diary")　　　　　　　　　　　　　　　
大園 秀一, 石田 也寸志, 清谷 知賀子, 岩井 艶子, 黒田 達夫, 藤 浩, 佐藤 伊織, 前田 美穂, 細井 創, 足立 壯一, 真部 淳, 福澤 正洋, 水谷 修紀, JCCG長期フォローアップ委員会, 日本小児血液・がん学会雑誌, 53, 4, 265, 265, Nov. 2016
(一社)日本小児血液・がん学会, English

小児における特発性骨髄不全症候群の遺伝的背景(Genetic background of idiopathic bone marrow failure syndromes in children)
Narita Atsushi, Okuno Yusuke, Muramatsu Hideki, Yoshida Kenichi, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Wang Xinan, Kawashima Nozomu, Nishio Nobuhiro, Hama Asahito, Takahashi Yoshiyuki, Hasegawa Daisuke, Manabe Atsushi, Sakaguchi Hirotoshi, Yoshida Nao, Kato Koji, Miyano Satoru, Ito Masafumi, Ogawa Seishi, Kojima Seiji, 臨床血液, 57, 9, 1490, 1490, Sep. 2016
(一社)日本血液学会-東京事務局, English

非血縁同種骨髄移植後に重症腎TMAを発症した骨髄異形成症候群の8歳女児例
宮本智史, 宮本智史, 木村俊介, 石田悠志, 代田惇朗, 松井俊大, 吉本優里, 平林真介, 細谷要介, 藤丸拓也, 長谷川大輔, 熊本忠史, 森慎一郎, 鈴木高祐, 真部淳, 日本造血細胞移植学会総会プログラム・抄録集, 38th, 2016

小児最重症再生不良性貧血に対する非血縁者間臍帯血移植
木村俊介, 長谷川大輔, 松井俊大, 代田惇朗, 石田悠志, 吉本優里, 平林真介, 細谷要介, 吉原宏樹, 熊本忠史, 森愼一郎, 真部淳, 日本小児血液・がん学会雑誌(Web), 53, 1, 2016

Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia : Swaminathan S. (Journal club : 抄読会(第52回))
吉本 優里, 真部 淳, 小児科臨床, 69, 1, 149, 152, Jan. 2016
日本小児医事出版社, Japanese

Lack of association between L-asparaginase allergy and rs6021191 variant in NFATC2 in Japanese children with acute lymphoblastic leukemia
田中庸一, ウラヤマ ケビン, 森麻希子, 長谷川大輔, 石丸紗恵, 寺田和樹, 柳町昌克, 太田節雄, 高橋浩之, 外山大輔, 慶野大, 森脇浩一, 高木正稔, 藤村純也, 関中悠仁, 中村こずえ, 佐藤雄弥, 小原明, 康勝好, 真部淳, 日本小児血液・がん学会雑誌(Web), 53, 4, 2016

Two cases of pediatric BCL2 and MYC dual-hit leukemia between 2002 and 2011 in Japan
坂口公祥, 今村俊彦, 石丸紗恵, 今井千速, 下之段秀美, 岡田恵子, 出口隆生, 橋井佳子, 清河信敬, 齋藤明子, 真部淳, 佐藤篤, 康勝好, 日本小児血液・がん学会雑誌(Web), 53, 4, 2016

The characteristics of Bilineal Leukemia diagnosed by nationwide immunophenotyping for pediatric hematological malignancy in Japan
出口隆生, 清河信敬, 大木健太郎, 橋井佳子, 真部淳, 足立壯一, 齋藤明子, 堀部敬三, 駒田美弘, 日本小児血液・がん学会雑誌(Web), 53, 4, 2016

特発性造血障害に関する調査研究 先天性造血不全症候群の研究
中畑龍俊, 真部淳, 長谷川大輔, 小島勢二, 矢部普正, 小原明, 特発性造血障害に関する調査研究 平成27年度 総括・分担研究報告書, 45‐48, 2016
Japanese

The Outcome of Relapsed Childhood Core Binding Factor Acute Myeloid Leukemia: A Report from the JPLSG AML-05R Study
Hiroshi Moritake, Shiro Tanaka, Hideki Nakayama, Takako Miyamura, Shotaro Iwamoto, Akira Shimada, Kiminori Terui, Akiko M. Saito, Norio Shiba, Yasuhide Hayashi, Daisuke Tomizawa, Takashi Taga, Hiroaki Goto, Atsushi Manabe, Keizo Horibe, Shuki Mizutani, Souichi Adachi, BLOOD, 126, 23, Dec. 2015
English, Summary international conference

TAL1 and MYB Abnormalities in Childhood T-Cell Acute Lymphoblastic Leukemia
Masafumi Seki, Kenichi Yoshida, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Motohiro Kato, Shunsuke Kimura, Ryoji Hanada, Katsuyoshi Koh, Satoru Miyano, Toshihiko Imamura, Keizo Horibe, Nobutaka Kiyokawa, Atsushi Manabe, Akira Ohara, Yasuhide Hayashi, Akira Oka, Seishi Ogawa, Junko Takita, BLOOD, 126, 23, Dec. 2015
English, Summary international conference

The Characteristics of Blastic Plasmacytoid Dendritic Cell Neoplasms Presenting Leukemia Dissemination, Diagnosed By Nation-Wide Immunophenotyping for Pediatric Hematological Malignancy in Japan
Takao Deguchi, Nobutaka Kiyokawa, Yoshiko Hashii, Akiko M. Saito, Atsushi Manabe, Keizo Horibe, Yoshihiro Komada, BLOOD, 126, 23, Dec. 2015
English, Summary international conference

Genetic Susceptibility Loci for Childhood Acute Lymphoblastic Leukemia Among Japanese
Kevin Y. Urayama, Masatoshi Takagi, Takahisa Kawaguchi, Keitaro Matsuo, Yoichi Tanaka, Yuki Arakawa, Daisuke Hasegawa, Yuki Yuza, Takashi Kaneko, Yasushi Noguchi, Yuichi Taneyama, Setsuo Ota, Takeshi Inukai, Masakatsu Yanagimachi, Dai Keino, Kazutoshi Koike, Daisuke Toyama, Yozo Nakazawa, Hidernitsu Kurosawa, Kozue Nakamura, Koichi Moriwaki, Hiroaki Goto, Yujin Sekinaka, Daisuke Morita, Motohiro Kato, Katsuyoshi Koh, Yasushi Ishida, Akira Ohara, Shuki Mizutani, Fumihiko Matsuda, Atsushi Manabe, BLOOD, 126, 23, Dec. 2015
English, Summary international conference

A novel recurrent EP300-ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia
Y. Gocho, N. Kiyokawa, H. Ichikawa, K. Nakabayashi, T. Osumi, T. Ishibashi, H. Ueno, K. Terada, K. Oboki, H. Sakamoto, Y. Shioda, M. Imai, Y. Noguchi, Y. Arakawa, Y. Kojima, D. Toyama, K. Hata, T. Yoshida, K. Matsumoto, M. Kato, T. Fukushima, K. Koh, A. Manabe, A. Ohara, LEUKEMIA, 29, 12, 2445, 2448, Dec. 2015
English, Report scientific journal

Comparison of Clinical and Laboratory Features Between Pediatric Aplastic Anemia and Refractory Cytopenia of Childhood
Asahito Hama, Atsushi Manabe, Daisuke Hasegawa, Hideki Muramatsu, Yoshiyuki Takahashi, Kenichiro Watanabe, Akira Ohara, Masafumi Ito, Seiji Kojima, BLOOD, 126, 23, Dec. 2015
English, Summary international conference

FIVE CASES OF PEDIATRIC-ONSET BEHCET DISEASE COMPLICATED WITH MYELODYSPLASTIC SYNDROME
K. Kanamitsu, R. Nishiuchi, K. Yamato, T. Shigemura, Y. Nakazawa, K. Koike, Y. Shinkoda, Y. Kawano, H. Ueno, A. Manabe, K. Yasui, H. Goto, K. Sasaki, S. Yokota, A. Shimada, LEUKEMIA RESEARCH, 39, S96, S96, Apr. 2015
English, Summary international conference

Blast crisis of juvenile myelomonocytic leukemia
本田 裕子, 真部 淳, 血液内科, 70, 3, 397, 402, Mar. 2015
科学評論社, Japanese

小児不応性血球減少症に対する造血幹細胞移植;日本小児血液学会前方視的登録例より
長谷川大輔, 平林真介, 渡辺静, 在家裕司, 土田昌宏, 増永敦子, 吉見礼美, 濱麻人, 小島勢二, 伊藤雅文, 中畑龍俊, 真部淳, 日本造血細胞移植学会総会プログラム・抄録集, 37th, 251, 06 Feb. 2015
Japanese

非血縁者間臍帯血移植を行った小児最重症再生不良性貧血の1例
木村俊介, 長谷川大輔, 松井俊大, 小野沙裕子, 石田悠志, 吉本優里, 平林真介, 細谷要介, 吉原宏樹, 熊本忠志, 真部淳, 日本造血細胞移植学会総会プログラム・抄録集, 37th, 2015

小児再生不良性貧血におけるリンパ球テロメア長と造血幹細胞移植予後との関連
成田敦, 坂口大俊, 関屋由子, 奥野友介, 村松秀城, 川島希, 土居崎小夜子, 濱麻人, 高橋義行, 吉田奈央, 伊藤雅文, 長谷川大輔, 真部淳, 矢部普正, 小林良二, 小島勢二, 日本造血細胞移植学会総会プログラム・抄録集, 37th, 2015

特発性造血障害に関する調査研究 先天性造血不全症候群の研究
中畑龍俊, 真部淳, 小島勢二, 矢部普正, 小原明, 特発性造血障害に関する調査研究 平成26年度 総括・分担研究報告書, 76‐79, 2015
Japanese

SECONDARY CANCERS AFTER CANCER DIAGNOSIS IN CHILDHOOD: A HOSPITAL-BASED RETROSPECTIVE COHORT STUDY IN JAPAN
Y. Ishida, D. Qiu, M. Maeda, J. Fujimoto, H. Kigasawa, R. Kobayashi, M. Sato, J. Okamura, S. Yoshinaga, T. Rikiishi, H. Shichino, C. Kiyotani, K. Kudo, K. Asami, H. Hori, H. Kawaguchi, H. Inada, S. Adachi, A. Manabe, T. Kuroda, PEDIATRIC BLOOD & CANCER, 61, S198, S198, Dec. 2014
English, Summary international conference

Phase I/II Clinical Trial of Erwinia Asparaginase (Erwinase(R)) in Combination with Prednisolone, Vincristine and Pirarubicin in Children and Young Adults with Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LBL)
Chitose Ogawa, Atsushi Manabe, Hiroaki Goto, Katsuyoshi Koh, Daisuke Tomizawa, Keitaro Fukushima, Ken-ichiro Watanabe, Keizo Horibe, Atsushi Kikuta, Mitsuma Hamada, Akira Ohara, BLOOD, 124, 21, Dec. 2014
English, Summary international conference

Outcome of Adolescent and Young Adults with Acute Myeloid Leukemia Treated with Pediatric Protocols: A Report from the 3 Japanese Cooperative Studies
Daisuke Tomizawa, Tomoyuki Watanabe, Ryoji Hanada, Keizo Horibe, Yasuo Horikoshi, Shotaro Iwamoto, Akitoshi Kinoshita, Hiroshi Moritake, Hideki Nakayama, Akira Shimada, Takashi Taga, Hiroyuki Takahashi, Akio Tawa, Kiminori Terui, Hiroki Hori, Yoshifumi Kawano, Atsushi Kikuta, Atsushi Manabe, Souichi Adachi, BLOOD, 124, 21, Dec. 2014
English, Summary international conference

Central Morphology Review of Childhood Bone Marrow Failure in Japan
Asahito Hama, Manabe Atsushi, Daisuke Hasegawa, Kazue Nozawa, Yusuke Okuno, Masahiro Irie, Hideki Muramatsu, Yoshiyuki Takahashi, Kenichiro Watanabe, Akira Ohara, Masafumi Ito, Seiji Kojima, BLOOD, 124, 21, Dec. 2014
English, Summary international conference

RISK FACTORS OF LONG-TERM CENTRAL VENOUS CATHETERS (CVCS) COMPLICATION IN CHILDREN WITH HEMATO-ONCOLOGICAL DISORDERS
A. Sakoda, T. Kawano, Y. Hosoya, H. Yoshiwara, S. Hirabayashi, D. Hasegawa, M. Ozawa, H. Matsufuji, A. Manabe, O. Takahashi, PEDIATRIC BLOOD & CANCER, 61, S353, S353, Dec. 2014
English, Summary international conference

Genetic Abnormalities and Prognosis in Pediatric B-precursor Acute Lymphoblastic Leukemia Treated on Tokyo Children's Cancer Study Group Protocol
Kentaro Ohki, Myoung-ja Park, Yusuke Hara, Norio Shiba, Takashi Fukushima, Katsuyoshi Koh, Atsushi Manabe, Akira Ohara, Nobutaka Kiyokawa, Yasuhide Hayashi, BLOOD, 124, 21, Dec. 2014
English, Summary international conference

小児急性リンパ性白血病における6-メルカプトプリン/メトトレキサート関連遺伝子の再発リスクへの影響(The influence of genetic polymorphisms related with 6-mercaptopurine and methotrexate on the risk of relapse in childhood acute lymphoblastic leukemia)
田中 庸一, 真部 淳, 中舘 尚也, 慶野 大, 中村 こずえ, 康 勝好, 秋山 政晴, 植田 高弘, 小宮山 貴子, 日本小児血液・がん学会雑誌, 51, 4, 235, 235, Oct. 2014
(一社)日本小児血液・がん学会, English

B前駆細胞性急性リンパ芽球性白血病の新規融合遺伝子EP300-ZNF384 BCP-ALLの新たなサブグループ(Identification of a novel subset of B-cell precursor acute lymphoblastic leukemia with EP300-ZNF384 fusion gene)
牛腸 義宏, 清河 信敬, 市川 仁, 中林 一彦, 上野 瞳, 大隅 朋生, 石橋 武士, 寺田 和樹, 大保木 啓介, 坂本 裕美, 塩田 曜子, 今井 雅子, 野口 靖, 外山 大輔, 秦 健一郎, 吉田 輝彦, 松本 健治, 福島 敬, 康 勝好, 真部 淳, 小原 明, 日本小児血液・がん学会雑誌, 51, 4, 238, 238, Oct. 2014
(一社)日本小児血液・がん学会, English

小児Ph-like ALL症例の表面マーカー、遺伝子発現解析
飯島 一智, 清河 信敬, 吉原 宏樹, 富田 理, 小林 健一郎, 福島 敬, 林 泰秀, 菊地 陽, 康 勝好, 真部 淳, 小原 明, 日本小児血液・がん学会雑誌, 51, 3, 200, 205, Sep. 2014
(一社)日本小児血液・がん学会, Japanese

INVESTIGATION OF PH-LIKE ALL BY GENE SET ENRICHMENT ANALYSIS AND IDENTIFICATION OF THEIR SPECIFIC EXPRESSION GENES
K. Iijima, N. Kiyokawa, K. Nakabayashi, H. Ichikawa, T. Osumi, H. Yoshihara, K. Ohki, M. Kato, T. Fukushima, H. Shimada, T. Mori, A. Kinoshita, K. Matsumoto, K. Koh, A. Kikuchi, Y. Hayashi, A. Manabe, A. Ohara, HAEMATOLOGICA, 99, 5, 5, Jun. 2014
English, Summary international conference

Management of germinoma-induced diabetes insipidus with DDAVP during hydration for chemotherapy
木村 俊介, 伊藤 純子, 吉本 優里, 平林 真介, 細谷 要介, 吉原 宏樹, 長谷川 大輔, 真部 淳, ホルモンと臨床, 62, 5, 367, 371, May 2014
医学の世界社, Japanese

小児急性リンパ性白血病のキメラ遺伝子スクリーニング検査　　　　　　　　　　　　　　　
大木 圭子, 南木 融, 福島 敬, 清河 信敬, 康 勝好, 小原 明, 真部 淳, 川上 康, 医学検査, 63, 学会特集号, 175, 175, Apr. 2014
(一社)日本臨床衛生検査技師会, Japanese

点鼻あるいは経口デスモプレシン製剤を用いて化学療法中の尿崩症を管理した神経下垂体部胚細胞腫瘍の5例
木村俊介, 細谷要介, 石田悠志, 野村耕太郎, 吉本優里, 吉原宏樹, 長谷川大輔, 伊藤純子, 真部淳, 日本小児内分泌学会学術集会プログラム・抄録集, 48th, 2014

変異KRASの片親性ダイソミーにより急性転化したJMML
加藤 元博, 安井 直子, 関 正史, 岸本 宏志, 佐藤 亜以子, 長谷川 大輔, 清河 信敬, 小川 誠司, 真部 淳, 滝田 順子, 康 勝好, 花田 良二, 日本小児血液・がん学会雑誌, 50, 4, 651, 651, Dec. 2013
(一社)日本小児血液・がん学会, Japanese

B前駆細胞性ALL再発症例のマーカーの特徴に関する検討　　　　　　　　　　　　　　　
牛腸 義宏, 清河 信敬, 富田 理, 飯島 一智, 吉原 宏樹, 石橋 武士, 小林 健一郎, 福島 敬, 前田 美穂, 林 泰秀, 菊地 陽, 康 勝好, 真部 淳, 小原 明, 日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 55回・11回・18回, 202, 202, Nov. 2013
(NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Japanese

小児B前駆細胞型ALLにおけるEBF1-PDGFRB融合遺伝子の解析 TCCSG-ALL研究　　　　　　　　　　　　　　　
大木 健太郎, 朴 明子, 原 勇介, 柴 徳生, 大喜多 肇, 小林 健一郎, 外松 学, 福島 敬, 康 勝好, 花田 良二, 真部 淳, 菊地 陽, 土田 昌宏, 小原 明, 清河 信敬, 林 泰秀, 日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 55回・11回・18回, 244, 244, Nov. 2013
(NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Japanese

変異KRASの片親性ダイソミーにより急性転化したJMML
加藤 元博, 安井 直子, 関 正史, 岸本 宏志, 佐藤 亜以子, 長谷川 大輔, 清河 信敬, 小川 誠司, 真部 淳, 滝田 順子, 康 勝好, 花田 良二, 日本小児血液・がん学会雑誌, 50, 3, 496, 496, Oct. 2013
(一社)日本小児血液・がん学会, Japanese

Myelodysplastic syndrome and aplastic anemia in childhood : recent advances
上野 浩生, 真部 淳, 血液内科, 67, 3, 404, 410, Sep. 2013
科学評論社, Japanese

REAPPRAISAL OF NCI/ROME CRITERIA IN CHILDHOOD B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA: TOKYO CHILDREN'S CANCER STUDY GROUP STUDIES BETWEEN 1989 AND 2003
A. Manabe, K. Koh, K. Oshima, J. Fujimura, K. Ikuta, T. Saito, A. Kikuchi, R. Hanada, M. Tsuchida, A. Ohara, PEDIATRIC BLOOD & CANCER, 60, 66, 66, Sep. 2013
English, Summary international conference

HYPERSENSITIVITY TO ASPARAGINASE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
D. Hasegawa, S. Watanabe, H. Yoshihara, Y. Hosoya, C. Ogawa, K. Goto, R. Hosoya, A. Manabe, PEDIATRIC BLOOD & CANCER, 60, 63, 63, Sep. 2013
English, Summary international conference

NURSING CARE FOR CHILDREN WITH DOWN SYNDROME (DS) AND LEUKEMIA
J. Iida, M. Hirata, D. Hasegawa, A. Sekitomi, Y. Toriyama, W. Irie, R. Nishino, M. Ozawa, A. Manabe, R. Hosoya, PEDIATRIC BLOOD & CANCER, 60, 41, 41, Sep. 2013
English, Summary international conference

小児Ph-like ALLのマーカー所見の検討　　　　　　　　　　　　　　　
清河 信敬, 飯島 一智, 富田 理, 吉原 宏樹, 三春 晶嗣, 大隅 朋生, 嶋田 博之, 福島 敬, 森 鉄也, 斎藤 正博, 康 勝好, 真部 淳, 菊地 陽, 林 泰秀, 小原 明, Cytometry Research, 23, Suppl., 57, 57, Jun. 2013
(一社)日本サイトメトリー学会, Japanese

Cytomtric Bead Arrayを用いたBCR-ABL1蛋白検出の臨床的有用性　　　　　　　　　　　　　　　
富田 理, 清河 信敬, 三春 晶嗣, 石橋 武士, 大隅 朋生, 嶋田 博之, 福島 敬, 森 鉄也, 斎藤 正博, 康 勝好, 真部 淳, 菊地 陽, 林 泰秀, 小原 明, Cytometry Research, 23, Suppl., 58, 58, Jun. 2013
(一社)日本サイトメトリー学会, Japanese

Morphological differentiation of bone marrow failure syndromes in children according to 2008 WHO classification
A. Hama, A. Manabe, M. Ito, D. Hasegawa, K. Nozawa, H. Muramatsu, Y. Takahashi, A. Ohara, S. Kojima, LEUKEMIA RESEARCH, 37, S89, S89, May 2013
English, Summary international conference

Equivalent outcome between reduced-intensity versus conventional myeloablative conditioning haematopoietic stem cell transplantation for childhood MDS: a report from the MDS working group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT)
D. Hasegawa, A. Kikuchi, M. Yabe, M. Kato, K. Kudo, Y. Atsuta, J. Inagaki, M. Inoue, R. Nishimura, J. Tanaka, K. Kato, H. Yabe, K. Kawa, A. Manabe, K. Watanabe, BONE MARROW TRANSPLANTATION, 48, S296, S297, Apr. 2013
English, Summary international conference

思春期がん経験者のQOLと病気に関する自己開示
三井 千佳, 山崎 あけみ, 前田 尚子, 堀部 敬三, 浅見 恵子, 原 純一, 井田 孔明, 康 勝好, 小澤 美和, 真部 淳, 上別府 圭子, 日本小児血液・がん学会雑誌, 50, 1, 79, 84, Apr. 2013
(一社)日本小児血液・がん学会, Japanese

A Case of Burkitt Lymphoma with Multifocal Bone Invasion
TANAKA Chie, NOZAWA Kazue, SANO Akiko, UCHIKAWA Kaori, NAKAJIMA Atsuko, MANABE Atushi, TAKEDA Kyoko, 臨床病理, 61, 3, 231, 236, 25 Mar. 2013
日本臨床検査医学会事務所 ; 1953-, Japanese

小児B前駆細胞型ALLにおけるCRLF2高発現例の特徴 TCCSG-ALL研究　　　　　　　　　　　　　　　
大木 健太郎, 朴 明子, 柴 徳生, 清河 信敬, 康 勝好, 花田 良二, 真部 淳, 菊地 陽, 小原 明, 林 泰秀, 日本小児科学会雑誌, 117, 2, 345, 345, Feb. 2013
(公社)日本小児科学会, Japanese

小児不応性血球減少症の臨床像の検討 日本小児血液学会前方視的登録例より　　　　　　　　　　　　　　　
長谷川 大輔, 在家 裕司, 土田 昌宏, 増永 敦子, 吉見 礼美, 濱 麻人, 小島 勢二, 伊藤 雅文, 中畑 龍俊, 真部 淳, 日本小児血液, がん学会MDS委員会, 日本小児科学会雑誌, 117, 2, 370, 370, Feb. 2013
(公社)日本小児科学会, Japanese

血球貪食症候群の経過中に中枢神経症状を呈した3例の画像的考察
石田悠志, 長谷川大輔, 野崎太希, 細谷要介, 吉原宏樹, 平林真介, 神谷尚宏, 熊本忠史, 小川千登世, 細谷亮太, 森愼一郎, 真部淳, 日本小児血液・がん学会学術集会・日本小児がん看護学会・がんの子供を守る会公開シンポジウムプログラム・総会号, 55th-11th-18th, 2013

Telomere length as a predictor for the immunosuppressive therapy in acquired aplastic anemia
SAKAGUCHI Hirotoshi, NISHIO Nobuhiro, KAWASHIMA Nozomu, WANG Xinan, NARITA Atsushi, DOISAKI Sayoko, MURAMATSU Hideki, HAMA Asahito, NAKANISHI Koji, TAKAHASHI Yoshiyuki, TSUCHIDA Masahiro, KOBAYASHI Ryouji, ITOU Etsurou, YABE Hiromasa, OHGA Syouichi, OHARA Akira, HASEGAWA Daisuke, MANABE Atsushi, ITOU Masafumi, KOJIMA Seiji, 臨床血液, 54, 9, 2013

【臨床血液学 今後の展望(2013年版)-リンパ系疾患-】 小児急性リンパ性白血病　　　　　　　　　　　　　　　
真部 淳, 長谷川 大輔, 臨床血液, 54, 1, 100, 108, Jan. 2013
(一社)日本血液学会-東京事務局, Japanese

POSTTRAUMATIC STRESS SYMPTOMS AS AN IMPORTANT REACTION IN CHILDREN WHO DONATE THEIR STEM CELL TO THEIR SIBLINGS WITH CANCER
Miwa Ozawa, Asuka Higashi, Akiko Kobayashi, Disuke Hasegawa, Chitose Ogawa, Atsushi Manabe, Ryota Hosoya, ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 8, 247, 247, Nov. 2012
English, Summary international conference

CD66c陽性小児急性リンパ芽球性白血病の特徴　　　　　　　　　　　　　　　
富田 理, 清河 信敬, 三春 晶嗣, 小林 健一郎, 大喜多 肇, 長谷川 大輔, 嶋田 博之, 森 鉄也, 福島 敬, 斎藤 正博, 犬飼 岳史, 康 勝好, 杉田 完爾, 花田 良二, 土田 昌宏, 真部 淳, 菊地 陽, 藤本 純一郎, 林 泰秀, 小原 明, 東京小児がん研究グループ, 日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 54回・10回・17回, 286, 286, Nov. 2012
(NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Japanese

経過中に急性転化したJMML 23例の検討 MDS委員会のデータベースから　　　　　　　　　　　　　　　
本田 裕子, 土田 昌宏, 増永 敦子, 吉見 礼美, 小島 勢二, 伊藤 雅文, 菊地 陽, 中畑 龍俊, 真部 淳, 日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 54回・10回・17回, 251, 251, Nov. 2012
(NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Japanese

ダウン症候群に合併した一過性骨髄異常増殖症に対する少量シタラビン療法による腫瘍崩壊症候群　　　　　　　　　　　　　　　
村松 秀城, 菊地 陽, 林 泰秀, 川村 眞智子, 小島 勢二, 矢部 みはる, 磯山 恵一, 滝 智彦, 辻 浩一郎, 土田 昌宏, 真部 淳, 日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 54回・10回・17回, 282, 282, Nov. 2012
(NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Japanese

【MDS(骨髄異形成症候群)】 小児のMDS
長谷川 大輔, 真部 淳, 臨床検査, 56, 12, 1377, 1384, Nov. 2012
(株)医学書院, Japanese

若年性骨髄単球性白血病(JMML)の分子機構と治療
真部 淳, 臨床血液, 53, 8, 729, 733, 30 Aug. 2012
Japanese

Congenital Dyserythropoietic Anemia : 現状と今後の課題
多賀 崇, 真部 淳, 日本小児科学会雑誌, 116, 7, 1075, 1080, 01 Jul. 2012
日本小児科学会, Japanese

FCMによるリンパ系腫瘍への新たなアプローチ 小児白血病MRD検出における10カラーフローサイトメトリーの有用性　　　　　　　　　　　　　　　
三春 晶嗣, 清河 信敬, 小林 健一郎, 大喜多 肇, 飯島 一智, 森 鉄也, 斎藤 正博, 福島 敬, 康 勝好, 真部 淳, 菊地 陽, 林 泰秀, 小原 明, Cytometry Research, 22, Suppl., 44, 44, Jun. 2012
(一社)日本サイトメトリー学会, Japanese

小児リンパ芽球性白血病のキメラ遺伝子、細胞マーカーと遺伝子発現プロファイルの特徴　　　　　　　　　　　　　　　
清河 信敬, 福島 敬, 小林 健一郎, 三春 晶嗣, 大喜多 肇, 飯島 一智, 森 鉄也, 斎藤 正博, 康 勝好, 真部 淳, 菊地 陽, 林 泰秀, 小原 明, Cytometry Research, 22, Suppl., 66, 66, Jun. 2012
(一社)日本サイトメトリー学会, Japanese

A case of Langerhans cell histiocytosis with severe anemia: Letterer-Siwe disease
Hitomi Nakamura, Yukari Zenke, Yoko Momose, Mamiko Masuzawa, Satoru Arai, Hikaru Eto, Atsushi Manabe, Yosuke Hosoya, Daisuke Hasegawa, JOURNAL OF DERMATOLOGY, 39, 118, 118, Jun. 2012
English, Summary international conference

がんを家族にどう伝えどう支えるか 乳がん患者の子どものこころ　　　　　　　　　　　　　　　
小澤 美和, 三浦 絵莉子, 石田 也寸志, 山内 英子, 真部 淳, 日本緩和医療学会学術大会プログラム・抄録集, 17回, 206, 206, Jun. 2012
(NPO)日本緩和医療学会, Japanese

小児がん経験者の晩期合併症の予測は可能か 聖路加国際病院小児科の経験
石田 也寸志, 渡辺 静, 小澤 美和, 米川 聡子, 小川 千登世, 長谷川 大輔, 細谷 要介, 吉原 宏樹, 真部 淳, 森本 克, 西村 昴三, 細谷 亮太, 日本小児血液・がん学会雑誌, 49, 1-2, 31, 39, May 2012
(NPO)日本小児血液・がん学会, Japanese

血液腫瘍(白血病,悪性リンパ腫) (特集 小児慢性疾患の生活指導 : 最新の知見から) -- (日常生活における管理・指導)
細谷 要介, 真部 淳, 小児科臨床, 65, 4, 615, 621, Apr. 2012
日本小児医事出版社, Japanese

Significance of TP53 gene abnormalities in childhood acute lymphoblastic leukemia
熊本 忠史, 真部 淳, 血液内科, 64, 4, 508, 512, Apr. 2012
科学評論社, Japanese

Wiskott-Aldrich syndrome presenting with a clinical picture resembling juvenile myelomonocytic leukaemia
A. Yoshimi, Y. Kamachi, K. Imai, T. Morio, N. Watanabe, A. Konoshita, N. Nakadate, K. Tamura, S. Oozono, R. Kobayashi, H. Kigasawa, M. Jakob, S. Nonoyama, A. Manabe, C. Niemeyer, S. Kojima, BONE MARROW TRANSPLANTATION, 47, S69, S70, Apr. 2012
English, Summary international conference

プライマリケア・マスターコース 小児科診療のすすめ 小児がん
真部 淳, 細谷 亮太, 日本医事新報, 4586, 46, 49, 17 Mar. 2012
日本医事新報社, Japanese

若年性骨髄単球性白血病75例の予後 小児血液学会MDS委員会の前方視的検討　　　　　　　　　　　　　　　
吉田 奈央, 平林 真介, 渡辺 静, 在家 裕司, 土田 昌宏, 吉見 礼美, 増永 敦子, 大塚 欣敏, 伊藤 雅文, 小島 勢二, 中畑 龍俊, 真部 淳, 臨床血液, 52, 12, 1853, 1858, Dec. 2011
(一社)日本血液学会-東京事務局, Japanese

A 9-year-old female with thoracic vertebral fracture
槇殿 文香理, 野崎 太希, 真部 淳, The Journal of pediatric practice, 74, 11, 1665, 1669, Nov. 2011
診断と治療社, Japanese

A 8-year-old female with upper arm swelling
野崎 太希, 槇殿 文香理, 真部 淳, The Journal of pediatric practice, 74, 11, 1835, 1839, Nov. 2011
診断と治療社, Japanese

A boy with fever and migratory pain
槇殿 文香理, 野崎 太希, 真部 淳, The Journal of pediatric practice, 74, 11, 1846, 1850, Nov. 2011
診断と治療社, Japanese

A Brief Use of Imatinib Immediately Before Hematopoietic Stem Cell Transplantation (HSCT) in Children with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph plus ALL). Results of the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) Study Ph+ALL04
Atsushi Manabe, Hirohide Kawasaki, Motoaki Chin, Atsushi Sato, Kimikazu Matsumoto, Tsutomu Watanabe, Michiko Kajiwara, Hiroyuki Shimada, Itaru Kato, Yuichi Kodama, Noriko Sato, Kazuko Kudo, Atsushi Kikuta, Megumi Oda, Tomoyuki Watanabe, Akiko M. Saito, Masahito Tsurusawa, Keizo Horibe, BLOOD, 118, 21, 1095, 1096, Nov. 2011
English, Summary international conference

Acute Lymphoblastic Leukemia in Children with Down Syndrome: A Report From the Ponte Di Legno Study Group
Trudy Buitenkamp, Shai Izraeli, Martin Zimmermann, Erik Forestier, Nyla A. Heerema, Marry M. van den Heuvel, Rob Pieters, Valerie de Haas, Lewis B. Silverman, Kjeld Schmiegelow, Der-Cherng Liang, Keizo Horibe, Maurizio Arico, Giovanni Cazzaniga, Giuseppe Basso, Karen R. Rabin, Martin Schrappe, Gunnar Cario, Georg Mann, Veerle Mondelaers, Tim Lammens, Helene Cave, Batia Stark, Anthony V. Moorman, Ajay J. Vora, Stephen Hunger, Ching-Hon Pui, Charles G. Mullighan, Atsushi Manabe, Gabriele Escherich, Jerzy Kowalczyk, James A. Whitlock, Christian M. Zwaan, BLOOD, 118, 21, 1527, 1528, Nov. 2011
English, Summary international conference

TCCSG ALL登録症例の細胞抗原とキメラ遺伝子との関連性についての検討　　　　　　　　　　　　　　　
小林 健一郎, 福島 敬, 南木 融, 清河 信敬, 三春 晶嗣, 山田 浩之, 飯島 一智, 大喜多 肇, 森 鉄也, 熊谷 昌明, 藤本 純一郎, 斎藤 正博, 康 勝好, 真部 淳, 菊地 陽, 林 泰秀, 土田 昌宏, 小原 明, 東京小児がん研究グループTCCSG, 小児がん, 48, プログラム・総会号, 212, 212, Nov. 2011
(NPO)日本小児がん学会, Japanese

東京小児がん研究グループ(TCCSG)ALL治療研究登録症例の網羅的遺伝子発現解析　　　　　　　　　　　　　　　
飯島 一智, 清河 信敬, 小林 健一郎, 大喜多 肇, 山田 浩之, 三春 晶嗣, 森 鉄也, 福島 敬, 南木 融, 斎藤 正博, 康 勝好, 真部 淳, 菊地 陽, 熊谷 昌明, 藤本 純一郎, 林 泰秀, 土田 昌宏, 小原 明, 東京小児がん研究グループTCCSG, 小児がん, 48, プログラム・総会号, 211, 211, Nov. 2011
(NPO)日本小児がん学会, Japanese

10カラーフローサイトメトリーを用いたB前駆細胞急性リンパ芽球性白血病のMRD検出　　　　　　　　　　　　　　　
三春 晶嗣, 清河 信敬, 小林 健一郎, 大喜多 肇, 山田 浩之, 飯島 一智, 森 鉄也, 福島 敬, 斎藤 正博, 康 勝好, 真部 淳, 菊地 陽, 熊谷 昌明, 藤本 純一郎, 林 泰秀, 土田 昌宏, 小原 明, 東京小児がん研究グループTCCSG, 小児がん, 48, プログラム・総会号, 247, 247, Nov. 2011
(NPO)日本小児がん学会, Japanese

小児ALLにおけるCRLF2、IKZF1、JAK2遺伝子の臨床的意義 TCCSGの小児B前駆細胞型急性リンパ性白血病におけるCRLF2とIKZF1の解析　　　　　　　　　　　　　　　
大木 健太郎, 大喜多 肇, 小林 健一郎, 清河 信敬, 朴 明子, 新井 心, 外松 学, 柴 徳生, 福島 敬, 康 勝好, 花田 良二, 真部 淳, 菊地 陽, 小原 明, 土田 昌宏, 林 泰秀, 小児がん, 48, プログラム・総会号, 174, 174, Nov. 2011
(NPO)日本小児がん学会, Japanese

若い乳がん患者とその子どもへのサポートを考える 子どもの行動・情緒的問題<続報>　　　　　　　　　　　　　　　
小澤 美和, 三浦 絵莉子, 石田 智美, 石田 也寸志, 真部 淳, 山内 英子, 日本乳癌学会総会プログラム抄録集, 19回, 428, 428, Sep. 2011
(一社)日本乳癌学会, Japanese

日本におけるL-asparaginase(L-asp)療法中の凝固障害に対する支持療法の調査(Survey of supportive therapy for coagulation disorder during L-asparaginase (L-asp) therapy in Japan)　　　　　　　　　　　　　　　
Ogawa Chitose, Manabe Atsushi, Ohara Akira, Ishiguro Akira, 臨床血液, 52, 9, 1078, 1078, Sep. 2011
(一社)日本血液学会-東京事務局, English

日本人小児における血栓症に関する初の全国調査(The first national survey of thrombotic disorders in Japanese children)　　　　　　　　　　　　　　　
Ishiguro Akira, Taki Masashi, Manabe Atsushi, Ogawa Chitose, Nakadate Hisaya, Shima Midori, 臨床血液, 52, 9, 1138, 1138, Sep. 2011
(一社)日本血液学会-東京事務局, English

The survey of supportive therapy for coagulation disorder during L-asparaginase (L-ASP) therapy in Japan
C. Ogawa, A. Manabe, A. Ohara, A. Ishiguro, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 9, 227, 227, Jul. 2011
English, Summary international conference

小児白血病におけるCD66c発現の意義　　　　　　　　　　　　　　　
山田 浩之, 清河 信敬, 橋本 亙, 飯島 一智, 嶋 晴子, 嶋田 博之, 森 鉄也, 福島 敬, 康 勝好, 真部 淳, 菊地 陽, 熊谷 昌明, 小原 明, 林 泰秀, 土田 昌宏, Cytometry Research, 21, Suppl., 78, 78, Jun. 2011
(一社)日本サイトメトリー学会, Japanese

カラーフローサイトメトリーを用いた小児白血病MRD検出の試み　　　　　　　　　　　　　　　
清河 信敬, 三春 晶嗣, 山田 浩之, 橋本 亙, 飯島 一智, 森 鉄也, 斎藤 正博, 福島 敬, 康 勝好, 真部 淳, 菊地 陽, 熊谷 昌明, 林 泰秀, 土田 昌宏, 小原 明, Cytometry Research, 21, Suppl., 80, 80, Jun. 2011
(一社)日本サイトメトリー学会, Japanese

特発性造血障害に関する調査研究 小児の骨髄不全と骨髄異形成症候群に関する研究
中畑龍俊, 真部淳, 特発性造血障害に関する調査研究 平成22年度 総括・分担研究報告書, 39, 45, 2011
Japanese

東京小児がん研究グループ急性リンパ性白血病治療研究におけるBCP-ALL-NCI-HR群の治療成績 特に年齢因子の検討　　　　　　　　　　　　　　　
藤村 純也, 高橋 浩之, 菊地 陽, 清河 信敬, 福島 敬, 康 勝好, 真部 淳, 花田 良二, 小原 明, 土田 昌宏, 小児がん, 47, プログラム・総会号, 396, 396, Dec. 2010
(NPO)日本小児がん学会, Japanese

ダウン症候群に合併した一過性骨髄異常増殖症148例の後方視的解析　　　　　　　　　　　　　　　
村松 秀城, 菊地 陽, 林 泰秀, 川村 眞智子, 小島 勢二, 矢部 みはる, 磯山 恵一, 滝 智彦, 辻 浩一郎, 土田 昌宏, 真部 淳, 小児がん, 47, プログラム・総会号, 221, 221, Dec. 2010
(NPO)日本小児がん学会, Japanese

Low-Dose Cytosine Arabinoside Therapy for Neonates with Down Syndrome (DS) and Transient Leukemia (TL)
Hideki Muramatsu, Yasuhide Hayashi, Machiko Kawamura, Seiji Kojima, Miharu Yabe, Keiichi Isoyama, Tomohiko Taki, Kohichiro Tsuji, Masahiro Tsuchida, Atsushi Manabe, Etsuro Ito, Shotaro Iwamoto, Hiromi Kato, Aiko Sumie, Takashi Taga, Keiko Nomura, Daisuke Hasegawa, Ken-ichiro Watanabe, Akira Kikuchi, BLOOD, 116, 21, 469, 470, Nov. 2010
English, Summary international conference

Epidemiological and Genetic Analysis of Sideroblastic Anemia - Multi-center Study In Japan
Rie Ohba, Kazumichi Furuyama, Shigeru Tsuchiya, Atsushi Manabe, Etsuro Ito, Seiji Kojima, Keiya Ozawa, Hideo Harigae, BLOOD, 116, 21, 1716, 1717, Nov. 2010, [Peer-reviewed]
English, Summary international conference

Histopathological review of pediatric bone marrow failures by objective MDS scoring system
M. Ito, A. Hama, A. Manabe, S. Kojima, HISTOPATHOLOGY, 57, 149, 150, Oct. 2010
English, Summary international conference

9 colorフローサイトメトリーによる小児白血病のマーカー解析
清河 信敬, 恩田 恵子, 高野 邦彦, 藤本 純一郎, 真部 淳, 康 勝好, 小原 明, 林 泰秀, 花田 良二, 土田 昌宏, Cytometry Research, 20, 2, 27, 33, Sep. 2010
(一社)日本サイトメトリー学会, Japanese

Myelodysplastic syndrome
真部 淳, The Journal of pediatric practice, 73, 8, 1352, 1356, Aug. 2010
診断と治療社, Japanese

THE IMPACT OF THE CANCER IN JAPANESE CHILDHOOD CANCER PATIENTS AFTER DISCHARGE FROM MEDICAL TREATMENT
Yuko Takei, Akiko Ogata, Miwa Ozawa, Atsushi Manabe, Hiroshi Moritake, Kei Hirai, Shinichi Suzuki, INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE, 17, 28, 29, Aug. 2010
English, Summary international conference

Refractory Cytopenia of Childhood anno 2010, State of the Art
HASEGAWA Daisuke, MANABE Atsushi, 日本小児血液学会雑誌, 24, 3, 161, 167, 30 Jun. 2010
Japanese

乳がん患者とその子どもへのサポートを考える 子どもの行動・情緒的問題　　　　　　　　　　　　　　　
小澤 美和, 伊藤 ゆかり, 阿佐美 百合子, 真部 淳, 山内 英子, 中村 清吾, 日本乳癌学会総会プログラム抄録集, 18回, 656, 656, May 2010
(一社)日本乳癌学会, Japanese

Clinical Characteristics of Seven Cases with Acute Lymphoblastic Leukemia Unable to Participate in a Clinical Trial because of the Advanced Organ Damage at Diagnosis : TCCSG L99-15 Study
SOTOMATSU Manabu, KANEKO Takashi, SAITO Masahiro, NOGUCHI Yasushi, TAKAHASHI Hiroyuki, YABE Miharu, MANABE Atsushi, OHARA Akira, HANADA Ryoji, TSUCHIDA Masahiro, 日本小児血液学会雑誌, 24, 1, 25, 31, 28 Feb. 2010
Japanese

白血病の分子標的療法 (ミニ特集 白血病)
真部 淳, 小児科臨床, 63, 1, 27, 33, Jan. 2010
日本小児医事出版社, Japanese

6.多発性骨浸潤により発症したバーキット・リンパ腫の一例(III,2009年度関東甲信越地区小児がん登録研究会)
斎藤 怜, 笠井 恵美, 神谷 尚宏, 長谷川 大輔, 小川 千登世, 真部 淳, 細谷 亮太, 小児がん : 小児悪性腫瘍研究会記録, 47, 3, 478, 478, 2010
がんの子供を守る会, Japanese

特発性造血障害に関する調査研究 小児の骨髄不全と骨髄異形成症候群に関する研究
中畑龍俊, 真部淳, 特発性造血障害に関する調査研究 平成21年度 総括・分担研究報告書, 38, 39, 2010
Japanese

C-Cbl but Not TET2 Mutations Are Present in Patients with Juvenile Myelomonocytic Leukemia
Hideki Muramatsu, Hideki Makishima, Anna Malgorzata Jankowska, Heather Cazzolli, Christine O'Keefe, Nao Yoshida, Yinyan Xu, Nobuhiro Nishio, Asahito Hama, Hiroshi Yagasaki, Yoshiyuki Takahashi, Koji Kato, Atsushi Manabe, Seiji Kojima, Jaroslaw P. Maciejewski, BLOOD, 114, 22, 174, 175, Nov. 2009
English, Summary international conference

A COMPREHENSIVE SUPPORT FOR FAMILIES HAVING CHILDREN WITH CANCER
Atsushi Manabe, Miwa Ozawa, Akiko Higuchi, Hiroko Kondo, Motohiro Matoba, Makiko Oshikawa, Shinichi Suzuki, Megumi Oda, Kiyoko Kamibeppu, Keizo Horibe, Ryota Hosoya, PEDIATRIC BLOOD & CANCER, 53, 5, 876, 877, Nov. 2009
English, Summary international conference

東京小児がん研究グループ急性リンパ性白血病治療12から15次研究におけるBCP-ALL-NCI-SR群治療成績の検討　　　　　　　　　　　　　　　
大嶋 宏一, 康 勝好, 小川 千登世, 富澤 大輔, 嶋田 博之, 福島 啓太郎, 藤村 純也, 徳山 美香, 長谷川 大輔, 太田 節雄, 高橋 浩之, 真部 淳, 熊谷 昌明, 菊地 陽, 小原 明, 花田 良二, 土田 昌宏, 小児がん, 46, プログラム・総会号, 226, 226, Nov. 2009
(NPO)日本小児がん学会, Japanese

TCCSG-L1602治療研究におけるDay8末梢血-芽球数のフローサイトメトリー測定についての評価　　　　　　　　　　　　　　　
恩田 恵子, 平林 真介, 清河 信敬, 齊藤 正博, 森 鉄也, 福島 敬, 藤本 純一郎, 真部 淳, 康 勝好, 熊谷 昌明, 小原 明, 林 泰秀, 花田 良二, 土田 昌宏, 小児がん, 46, プログラム・総会号, 228, 228, Nov. 2009
(NPO)日本小児がん学会, Japanese

東京小児がん研究グループにて1981年から1999年の5つの研究に登録された小児急性リンパ性白血病2035例の長期追跡結果　　　　　　　　　　　　　　　
土田 昌宏, 小原 明, 花田 良二, 真部 淳, 熊谷 昌明, 高橋 浩之, 金沢 崇, 藤村 純也, 富澤 大輔, 康 勝好, 嶋田 博之, 森 鉄也, 後藤 裕明, 福島 敬, 小池 和俊, 野口 靖, 小川 千登世, 犬飼 岳史, 福島 啓太郎, 塩原 正明, 加藤 陽子, 前田 美穂, 菊地 陽, 梶原 道子, 矢部 晋正, 外松 学, 太田 節雄, 磯山 恵一, 金子 隆, 林 泰秀, 東京小児がん研究グループALL委員会, 臨床血液, 50, 9, 904, 904, Sep. 2009
(一社)日本血液学会-東京事務局, Japanese

小児B細胞性リンパ腫のマイクロアレイを用いたmolecular karyotypingと網羅的発現遺伝子解析　　　　　　　　　　　　　　　
清河 信敬, 恩田 恵子, 飯島 一智, 長谷川 大輔, 加藤 元博, 大喜多 肇, 齋藤 正博, 森 鉄也, 真部 淳, 康 勝好, 小原 明, 林 泰秀, 花田 良二, 土田 昌宏, 中川 温子, 小川 誠司, 藤本 純一郎, 臨床血液, 50, 9, 1268, 1268, Sep. 2009
(一社)日本血液学会-東京事務局, Japanese

Hepatic Veno-Occlusive Disease (VOD) during Early Intensification Therapy of Acute Lymphoblastic Leukemia (ALL)
YOSHIDA Kenichi, HASEGAWA Daisuke, NAKASHIMA Kentaro, ARIMA Keitaro, HIRABAYASHI Shinsuke, OGAWA Chitose, MANABE Atsushi, HOSOYA Ryota, 日本小児血液学会雑誌, 23, 4, 251, 255, 31 Aug. 2009
Japanese

Treatment of adolescents and young adults with acute lymphoblastic leukemia
真部 淳, 血液・腫瘍科, 59, 1, 88, 92, Jul. 2009
科学評論社, Japanese

TCCSG-L1602治療研究/Day8末梢血 芽球数のフローサイトメトリー測定　　　　　　　　　　　　　　　
恩田 恵子, 清河 信敬, 齋藤 正博, 森 鉄也, 藤本 純一郎, 真部 淳, 康 勝好, 小原 明, 林 泰秀, 花田 良二, 土田 昌宏, Cytometry Research, 19, 抄録集, 57, 57, Jun. 2009
(一社)日本サイトメトリー学会, Japanese

MYELODYSPLASTIC SYNDROME AND MYELOPROLIFERATIVE DISEASE IN CHILDREN: A PROSPECTIVE REGISTRATION OF 222 CASES
A. Manabe, S. Hirabayashi, S. Watanabe, Y. Zaike, M. Tsuchida, A. Masunaga, A. Yoshimi, M. Ito, A. Kikuchi, K. Tsuji, A. Ohara, S. Kojima, T. Nakahara, HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 94, S1, S1, Apr. 2009
English, Summary international conference

A JAPANESE PEDIGREE WITH RUNX1 MUTATION RESULTING IN FAMILIAL PLATELET DISORDER WITH PROPENSITY TO ACUTE MYELOGENOUS LEUKEMIA
D. Hasegawa, C. Ogawa, S. Hirabayashi, M. Park, Y. Hayashi, A. Manabe, R. Hosoya, HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 94, S24, S24, Apr. 2009
English, Summary international conference

CONGENITAL MYELOPROLIFERATIVE DISEASE WITH GATA-1 MUTATION IN A PHENOTYPICALLY NORMAL INFANT
S. Hirabayashi, K. Arima, T. Kamiya, D. Hasegawa, C. Ogawa, A. Manabe, R. Hosoya, E. Ito, HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 94, S29, S29, Apr. 2009
English, Summary international conference

IMPACT OF GM-CSF SIGNALING PATHWAY-RELATED GENES ON CLINICAL OUTCOME OF CHILDREN WITH JUVENILE MYELOMONOCYTIC LEUKEMIA
N. Yoshida, H. Yagasaki, Y. Xu, K. Matsuda, A. Yoshimi, Y. Takahashi, K. Matsumoto, K. Kato, J. Ueyama, H. Inada, H. Goto, M. Yabe, K. Kudo, J. Mimaya, A. Kikuchi, K. Koike, A. Manabe, S. Kojima, HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 94, S15, S15, Apr. 2009
English, Summary international conference

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION WITH FLUDARABINE-CONTAINING REGIMEN IN CHILDREN WITH JUVENILE MYELOMONOCYTIC LEUKEMIA
N. Yabe, A. Manabe, Y. Ohtsuka, K. Watanabe, M. Imamura, M. Kaneda, R. Miyachi, J. Inagaki, Y. Ebihara, N. Yoshida, K. Sakashita, K. Horibe, M. Tsurusawa, HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 94, S26, S27, Apr. 2009
English, Summary international conference

Pathological Central Review of Myelodysplastic Syndrome in 445 Children
HIRABAYASHI Shinsuke, MANABE Atsushi, 日本小児血液学会雑誌, 23, 1, 53, 57, 28 Feb. 2009
Japanese

Feasibility of WT1 peptide vaccination for the treatment of refractory hematological and solid malignancies in children
SAWADA Akihisa, INOUE Masami, KONDO Osamu, KIMOTO Tomiko, YAMADA Kayo, NAKAYAMA Masahiro, KUWAE Yuko, NISHIKAWA Masanori, OKAWA Hiroji, IDA Kohemi, TOKUDA Kiriko, MANABE Atsushi, TSUCHIYA Kunihiko, OKUYAMA Hiroomi, KUBOTA Akio, KAWAHARA Hisayoshi, HASEGAWA Toshimiti, YONEDA Akihiro, TAKEMOTO Osamu, YAMADA Junji, KAWABATA Hidehiko, TAMURA Daisuke, KINOUCHI Keiko, HIRANO Shinya, UNO Makoto, TAKESHITA Yasufumi, ISHIHARA Takashi, OKAMURA Takayuki, SAKATA Naoki, MIZUTANI Syuki, NAKAHATA Tatsutoshi, SAKO Masahiro, TAWA Akio, OJI Yusuke, TSUBOI Akihiro, KOYAMA Maho, OKA Yoshihiro, YASUI Masahiro, SUGIYAMA Haruo, KAWA Keisei, 小児がん : 小児悪性腫瘍研究会記録 = Pediatric oncology, 46, 1, 6, 16, 25 Feb. 2009
がんの子供を守る会, Japanese

Myelodysplastic syndromes: focused on refractory anemia/cytopenia
長谷川 大輔, 真部 淳, The Journal of pediatric practice, 72, 2, 345, 354, Feb. 2009
診断と治療社, Japanese

1.膀胱Rhabdoid tumorの女児例(2008年度関東甲信越地区小児がん登録研究会)
比嘉 千明, 中島 健太郎, 吉田 健一, 平林 真介, 神谷 尚宏, 長谷川 大輔, 小川 千登世, 真部 淳, 細谷 亮太, 中村 晃子, 平林 健, 鈴木 高祐, 小児がん : 小児悪性腫瘍研究会記録, 46, 3, 412, 413, 2009
がんの子供を守る会, Japanese

特発性造血障害に関する調査研究 小児骨髄異形成症候群に関する研究
中畑龍俊, 真部淳, 特発性造血障害に関する調査研究 平成20年度 総括・分担研究報告書, 41, 42, 2009
Japanese

Clinical Outcome of 640 Children with Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Treated Between 1995 and 2005
Maurizio Arica, Martin Schrappe, Stephen Hunger, William L. Carroll, Valentino Conter, Paola Di Lorenzo, Atsushi Manabe, Vaskar Saba, Andre Baruchel, Kim Vettenranta, Masahiro Tsuchida, Yves Benoit, Rob Pieters, Gabriele Escherich, Lewis B. Silverman, Ching-Hon Pui, Maria Grazia Valsecchi, BLOOD, 112, 11, 213, 214, Nov. 2008
English, Summary international conference

Significance of Initial Lumbar Puncture on Day8 of Remission Induction Therapy in Childhood Acute Lymphoblastic Leukemia: The Results from the Tokyo Children's Cancer Study Group L99-15 Protocol
Daisuke Hasegawa, Atsushi Manabe, Akira Ohara, Katsuyoshi Koh, Chitose Ogawa, Ryoji Hanada, Masahiro Tsuchida, BLOOD, 112, 11, 339, 339, Nov. 2008
English, Summary international conference

B precursor-ALLに対する中枢神経白血病予防治療の変遷と成績 TCCSG ALL L89-12,92-13,95-14,99-15研究　　　　　　　　　　　　　　　
小川 千登世, 小原 明, 真部 淳, 菊地 陽, 康 勝好, 富澤 大輔, 藤村 純也, 井上 裕靖, 角南 勝介, 石井 栄三郎, 塩原 正明, 森 鉄也, 高橋 裕之, 林 泰秀, 花田 良二, 土田 昌宏, 小児がん, 45, プログラム・総会号, 190, 190, Nov. 2008
(NPO)日本小児がん学会, Japanese

MDSセントラルレビュー症例の解析　　　　　　　　　　　　　　　
平林 真介, 渡辺 静, 真部 淳, 土田 昌宏, 在家 裕司, 増永 敦子, 菅原 幸子, 吉見 礼美, 伊藤 雅文, 辻 浩一郎, 菊地 陽, 中畑 龍俊, 小児がん, 45, プログラム・総会号, 160, 160, Nov. 2008
(NPO)日本小児がん学会, Japanese

20-P2-324 小児急性リンパ性白血病患者におけるex vivoアンモニア上昇値をパラメータとしたL-アスパラギナーゼの効果評価(がん薬物療法(その他),来るべき時代への道を拓く)
渡辺 静, 三宅 久美子, 松本 晴菜, 小川 千登世, 長谷川 大輔, 真部 淳, 木津 純子, 細谷 亮太, 日本医療薬学会年会講演要旨集, 18, 336, 336, 01 Sep. 2008
日本医療薬学会, Japanese