Mathematical mechanistic model representing the cancer immunity cycle under radiation effects
Taisuke Takayanagi, Koichi Miyazaki, Kana Yamasaki, Takahiro Yamada, Futaro Ebina, Takahiro Kanehira, Yasuhito Onodera, Keiji Kobashi, Hiroshi Taguchi, Koichi Yasuda, Norio Katoh, Takayuki Hashimoto, Hidefumi Aoyama, Hiroki Shirato, Kenji Chamoto
Scientific Reports, 15, 1, Springer Science and Business Media LLC, 06 Jun. 2025, [Peer-reviewed]
Scientific journal

Evaluation of the glottic surface dose in three‐dimensional conformal radiotherapy for early‐stage glottic cancer using a treatment planning system
Yuki Saito, Takahiro Kanehira, Takahito Yuki, Miyako Myojin
Journal of Applied Clinical Medical Physics, Wiley, 14 Apr. 2025, [Peer-reviewed], [Corresponding author]
Scientific journal, ABSTRACT

Background

In radiotherapy for early‐stage glottic cancer, evaluating the target surface dose at the glottic air–tissue boundary is crucial, as buildup effect can cause underdosing. The accuracy of dose evaluation in the surrounding tissues is affected by both the dose calculation algorithms and the accuracy of the Hounsfield unit values in the glottic air cavities.

Purpose

The objective of this study is to investigate the impact of dose calculation algorithms and material override on glottic surface dose calculations in three‐dimensional conformal radiotherapy (3DCRT) for glottic cancer.

Methods

We retrospectively included three patients with early‐stage glottic cancer treated with 3DCRT. Treatment planning based on the collapsed cone convolution (CCC) algorithm in the treatment planning system with a 1‐mm dose grid was conducted using a prescribed dose of 65 Gy in 26 fractions. The contours of the glottic air cavities and the surrounding glottic tissues were delineated for material override to air and water, respectively to assign correct materials in dose calculation. Each treatment plan was initially calculated using CCC without material override (CCC_w/o) and recalculated using CCC with material override (CCC_w) as well as photon Monte Carlo (pMC) algorithm with and without material override (pMC_w and pMC_w/o, respectively). A 1‐mm glottic surface dose (D_99%) was evaluated using CCC_w/o, CCC_w, pMC_w, and pMC_w/o.

Results

PMC_w predicted a ∼13.0% reduction in the glottic surface dose compared with the prescribed dose. CCC_w/o, CCC_w, and pMC_w/o overestimated the dose by ∼10.0% compared with pMC_w. The difference between CCC_w/o and pMC_w/o was minimal (0.6%); pMC_w/o significantly overestimated (by 10.8%) the dose compared with pMC_w, indicating the significant impact of material override in pMC.

Conclusion

Monte Carlo dose calculations with material override are essential for the accurate surface dose calculation in 3DCRT for glottic cancer. Without appropriate material override, both CCC and pMC overestimate the surface dose.

Normal tissue complication probability model for severe radiation-induced lymphopenia in patients with pancreatic cancer treated with concurrent chemoradiotherapy
Fuki Koizumi, Norio Katoh, Takahiro Kanehira, Yasuyuki Kawamoto, Toru Nakamura, Tatsuhiko Kakisaka, Miyako Myojin, Noriaki Nishiyama, Akio Yonesaka, Manami Otsuka, Rikiya Takashina, Hideki Minatogawa, Hajime Higaki, Yusuke Uchinami, Hiroshi Taguchi, Kentaro Nishioka, Koichi Yasuda, Naoki Miyamoto, Isao Yokota, Keiji Kobashi, Hidefumi Aoyama
Physics and Imaging in Radiation Oncology, 100690, 100690, Elsevier BV, Dec. 2024, [Peer-reviewed]
Scientific journal

Geometric target margin strategy of proton craniospinal irradiation for pediatric medulloblastoma.
Takaaki Yoshimura, Keigo Kondo, Takayuki Hashimoto, Kentaro Nishioka, Takashi Mori, Takahiro Kanehira, Taeko Matsuura, Seishin Takao, Hiroshi Tamura, Takuya Matsumoto, Kenneth Sutherland, Hidefumi Aoyama
Journal of radiation research, 15 Sep. 2024, [Peer-reviewed], [International Magazine]
English, Scientific journal, In proton craniospinal irradiation (CSI) for skeletally immature pediatric patients, a treatment plan should be developed to ensure that the dose is uniformly delivered to all vertebrae, considering the effects on bone growth balance. The technical (t) clinical target volume (CTV) is conventionally set by manually expanding the CTV from the entire intracranial space and thecal sac, based on the physician's experience. However, there are differences in contouring methods among physicians. Therefore, we aimed to propose a new geometric target margin strategy. Nine pediatric patients with medulloblastoma who underwent proton CSI were enrolled. We measured the following water equivalent lengths for each vertebra in each patient: body surface to the dorsal spinal canal, vertebral limbus, ventral spinal canal and spinous processes. A simulated tCTV (stCTV) was created by assigning geometric margins to the spinal canal using the measurement results such that the vertebral limb and dose distribution coincided with a margin assigned to account for the uncertainty of the proton beam range. The stCTV with a growth factor (correlation between body surface area and age) and tCTV were compared and evaluated. The median values of each index for cervical, thoracic and lumber spine were: the Hausdorff distance, 9.14, 9.84 and 9.77 mm; mean distance-to-agreement, 3.26, 2.65 and 2.64 mm; Dice coefficient, 0.84, 0.81 and 0.82 and Jaccard coefficient, 0.50, 0.60 and 0.62, respectively. The geometric target margin setting method used in this study was useful for creating an stCTV to ensure consistent and uniform planning.

Clinical application of real-time tumor-tracking for stereotactic volumetric modulated arc therapy for liver tumors.
Naoki Miyamoto, Norio Katoh, Takahiro Kanehira, Kohei Yokokawa, Ryusuke Suzuki, Yusuke Uchinami, Hiroshi Taguchi, Daisuke Abo, Hidefumi Aoyama
Physics and imaging in radiation oncology, 31, 100623, 100623, Jul. 2024, [Peer-reviewed], [International Magazine]
English, Scientific journal, Real-time tumor-tracking volumetric modulated arc therapy (RT-VMAT) enabling beam-gating based on continuous X-ray tracking of the three-dimensional position of internal markers is relevant for moving tumors. Dose-volume characteristics and treatment time were evaluated in ten consecutive patients who underwent liver stereotactic body radiation therapy with RT-VMAT. Target dose conformity and sparing of the stomach and the intestine were improved comparing RT-VMAT with RT-3D conformal radiotherapy. The mean treatment time for each fraction was less than 10 min. RT-VMAT could be effective, especially for targets located adjacent to organs at risk.

A new predictive parameter for dose‐volume metrics in intensity‐modulated radiation therapy planning for prostate cancer: Initial phantom study
Yuki Saito, Ryusuke Suzuki, Naoki Miyamoto, Kenneth Lee Sutherland, Takahiro Kanehira, Masaya Tamura, Takashi Mori, Kentaro Nishioka, Takayuki Hashimoto, Hidefumi Aoyama
Journal of Applied Clinical Medical Physics, Apr. 2024, [Peer-reviewed]
Scientific journal

Probability of normal tissue complications for hematologic and gastrointestinal toxicity in postoperative whole pelvic radiotherapy for gynecologic malignancies using intensity-modulated proton therapy with robust optimization.
Takaaki Yoshimura, Ryota Yamada, Rumiko Kinoshita, Taeko Matsuura, Takahiro Kanehira, Hiroshi Tamura, Kentaro Nishioka, Koichi Yasuda, Hiroshi Taguchi, Norio Katoh, Keiji Kobashi, Takayuki Hashimoto, Hidefumi Aoyama
Journal of radiation research, 17 Mar. 2024, [Peer-reviewed], [International Magazine]
English, Scientific journal, This retrospective treatment-planning study was conducted to determine whether intensity-modulated proton therapy with robust optimization (ro-IMPT) reduces the risk of acute hematologic toxicity (H-T) and acute and late gastrointestinal toxicity (GI-T) in postoperative whole pelvic radiotherapy for gynecologic malignancies when compared with three-dimensional conformal radiation therapy (3D-CRT), intensity-modulated X-ray (IMXT) and single-field optimization proton beam (SFO-PBT) therapies. All plans were created for 13 gynecologic-malignancy patients. The prescribed dose was 45 GyE in 25 fractions for 95% planning target volume in 3D-CRT, IMXT and SFO-PBT plans and for 99% clinical target volume (CTV) in ro-IMPT plans. The normal tissue complication probability (NTCP) of each toxicity was used as an in silico surrogate marker. Median estimated NTCP values for acute H-T and acute and late GI-T were 0.20, 0.94 and 0.58 × 10-1 in 3D-CRT; 0.19, 0.65 and 0.24 × 10-1 in IMXT; 0.04, 0.74 and 0.19 × 10-1 in SFO-PBT; and 0.06, 0.66 and 0.15 × 10-1 in ro-IMPT, respectively. Compared with 3D-CRT and IMXT plans, the ro-IMPT plan demonstrated significant reduction in acute H-T and late GI-T. The risk of acute GI-T in ro-IMPT plan is equivalent with IMXT plan. The ro-IMPT plan demonstrated potential clinical benefits for reducing the risk of acute H-T and late GI-T in the treatment of gynecologic malignances by reducing the dose to the bone marrow and bowel bag while maintaining adequate dose coverage to the CTV. Our results indicated that ro-IMPT may reduce acute H-T and late GI-T risk with potentially improving outcomes for postoperative gynecologic-malignancy patients with concurrent chemotherapy.

Predicting the daily gastrointestinal doses of stereotactic body radiation therapy for pancreatic cancer based on the shortest distance between the tumor and the gastrointestinal tract using daily computed tomography images
Yusuke Uchinami, Takahiro Kanehira, Keiji Nakazato, Yoshihiro Fujita, Fuki Koizumi, Shuhei Takahashi, Manami Otsuka, Koichi Yasuda, Hiroshi Taguchi, Kentaro Nishioka, Naoki Miyamoto, Kohei Yokokawa, Ryusuke Suzuki, Keiji Kobashi, Keita Takahashi, Norio Katoh, Hidefumi Aoyama
BJR|Open, 5, 1, British Institute of Radiology, Aug. 2023, [Peer-reviewed]
English, Scientific journal, Objectives:

We aimed to investigate whether daily computed tomography (CT) images could predict the daily gastroduodenal, small intestine, and large intestine doses of stereotactic body radiation therapy (SBRT) for pancreatic cancer based on the shortest distance between the gross tumor volume (GTV) and gastrointestinal (GI) tract.

Methods:

Twelve patients with pancreatic cancer received SBRT of 40 Gy in five fractions. We recalculated the reference clinical SBRT plan (PLAN_ref) using daily CT images and calculated the shortest distance from the GTV to each GI tract. The maximum dose delivered to 0.5 cc (D_0.5cc) was evaluated for each planning at-risk volume of the GI tract. Spearman’s correlation test was used to determine the association between the daily change in the shortest distance (Δshortest distance) and the ratio of ΔD_0.5cc dose to D_0.5cc dose in PLAN_ref (ΔD_0.5cc/PLAN_ref) for quantitative analysis.

Results:

The median shortest distance in PLAN_ref was 0 mm in the gastroduodenum (interquartile range, 0–2.7), 16.7 mm in the small intestine (10.0–23.7), and 16.7 mm in the large intestine (8.3–28.1 mm). The D_0.5cc of PLAN_ref in the gastroduodenum was >30 Gy in all patients, with 10 (83.3%) having the highest dose. A significant association was found between the Δshortest distance and ΔD_0.5cc/ PLAN_ref in the small or large intestine (p < 0.001) but not in the gastroduodenum (p = 0.404).

Conclusions:

The gastroduodenum had a higher D_0.5cc and predicting the daily dose was difficult. Daily dose calculations of the GI tract are recommended for safe SBRT.

Advances in knowledge:

This study aimed to predict the daily doses in SBRT for pancreatic cancer from the shortest distance between the GTV and the gastrointestinal tract. Daily changes in the shortest distance can predict the daily dose to the small or large intestines, but not to the gastroduodenum.

Evaluation of short-term gastrointestinal motion and its impact on dosimetric parameters in stereotactic body radiation therapy for pancreatic cancer
Yusuke Uchinami, Takahiro Kanehira, Yoshihiro Fujita, Naoki Miyamoto, Kohei Yokokawa, Fuki Koizumi, Motoyasu Shido, Shuhei Takahashi, Manami Otsuka, Koichi Yasuda, Hiroshi Taguchi, Keiji Nakazato, Keiji Kobashi, Norio Katoh, Hidefumi Aoyama
Clinical and Translational Radiation Oncology, 39, 100576, 100576, Elsevier BV, Mar. 2023, [Peer-reviewed]
Scientific journal

Study of hepatic toxicity in small liver tumors after photon or proton therapy based on factors predicting the benefits of proton.
Yusuke Uchinami, Norio Katoh, Daisuke Abo, Ryo Morita, Hiroshi Taguchi, Yoshihiro Fujita, Takahiro Kanehira, Ryusuke Suzuki, Naoki Miyamoto, Seishin Takao, Taeko Matsuura, Takuya Sho, Koji Ogawa, Tatsuya Orimo, Tatsuhiko Kakisaka, Keiji Kobashi, Hidefumi Aoyama
The British journal of radiology, 96, 1144, 20220720, 20220720, 12 Jan. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: In a previous study of hepatic toxicity, the following three factors were identified to predict the benefits of proton beam therapy (PBT) for hepatocellular carcinomas (HCC) with a maximum diameter of ≤5 cm and Child-pugh grade A (CP-A): number of tumors (one vs ≥2), the location of tumors (hepatic hilum or others), and the sum of the diameters of lesions. The aim of this study is to analyze the association between these three factors and hepatic toxicity. METHODS: We retrospectively reviewed patients of CP-A treated with PBT or photon stereotactic body radiotherapy (X-ray radiotherapy, XRT) for HCC ≤5 cm. For normal liver dose, the V5, V10, V20 (volumes receiving 5, 10, and 20 Gy at least), and the mean dose was evaluated. The albumin-bilirubin (ALBI) and CP score changes from the baseline were evaluated at 3 and 6 months after treatment. RESULTS: In 89 patients (XRT: 48, PBT: 41), those with two or three (2-3) predictive factors were higher normal liver doses than with zero or one (0-1) factor. In the PBT group, the ALBI score worsened more in patients with 2-3 factors than those with 0-1 factor, at 3 months (median 0.26 vs 0.02, p = 0.032) and at 6 months (median: 0.35 vs 0.10, p = 0.009). The ALBI score change in the XRT group and CP score change in either modality were not significantly different in the number of predictive factors. CONCLUSIONS: The predictive factor numbers predicted the ALBI score change in PBT but not in XRT. ADVANCES IN KNOWLEDGE: This study suggest that the number of predictive factors previously identified (0-1 vs 2-3) were significantly associated with dosimetric parameters of the normal liver in both modalities. In the proton group, the number of predictive factors was associated with a worsening ALBI score at 3 and 6 months, but these associations were not found in the photon SBRT group.

Deformed dose restoration to account for tumor deformation and position changes for adaptive proton therapy.
Koichi Miyazaki, Yusuke Fujii, Takahiro Yamada, Takahiro Kanehira, Naoki Miyamoto, Taeko Matsuura, Koichi Yasuda, Yusuke Uchinami, Manami Otsuka, Hidefumi Aoyama, Seishin Takao
Medical physics, 50, 2, 675, 687, 11 Dec. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Online adaptation during intensity-modulated proton therapy (IMPT) can minimize the effect of inter-fractional anatomical changes, but remains challenging because of the complex workflow. One approach for fast and automated online IMPT adaptation is dose restoration, which restores the initial dose distribution on the updated anatomy. However, this method may fail in cases where tumor deformation or position changes occur. PURPOSE: To develop a fast and robust IMPT online adaptation method named "deformed dose restoration (DDR)" that can adjust for inter-fractional tumor deformation and position changes. METHODS: THE DDR METHOD COMPRISES TWO STEPS: : (1) calculation of the deformed dose distribution, and (2) restoration of the deformed dose distribution. First, the deformable image registration (DIR) between the initial clinical target volume (CTV) and the new CTV were performed to calculate the vector field. To ensure robustness for setup and range uncertainty and the ability to restore the deformed dose distribution, an expanded CTV-based registration to maintain the dose gradient outside the CTV was developed. The deformed dose distribution was obtained by applying the vector field to the initial dose distribution. Then, the voxel-by-voxel dose difference optimization was performed to calculate beam parameters that restore the deformed dose distribution on the updated anatomy. The optimization function was the sum of total dose differences and dose differences of each field to restore the initial dose overlap of each field. This method only requires target contouring, which eliminates the need for organs at risk (OARs) contouring. Six clinical cases wherein the tumor deformation and/or position changed on repeated CTs were selected. DDR feasibility was evaluated by comparing the results with those from three other strategies, namely, not adapted (continuing the initial plan), adapted by previous dose restoration, and fully optimized. RESULTS: In all cases, continuing the initial plan was largely distorted on the repeated CTs and the dose-volume histogram (DVH) metrics for the target were reduced due to the tumor deformation or position changes. On the other hand, DDR improved DVH metrics for the target to the same level as the initial dose distribution. Dose increase was seen for some OARs because tumor growth had reduced the relative distance between CTVs and OARs. Robustness evaluation for setup and range uncertainty (3 mm/3.5%) showed that deviation in DVH-bandwidth for CTV D95% from the initial plan was 0.4 ± 0.5% (Mean ± S.D.) for DDR. The calculation time was 8.1 ± 6.4 min. CONCLUSIONS: An online adaptation algorithm was developed that improved the treatment quality for inter-fractional anatomical changes and retained robustness for intra-fractional setup and range uncertainty. The main advantage of this method is that it only requires target contouring alone and saves the time for OARs contouring. The fast and robust adaptation method for tumor deformation and position changes described here can reduce the need for offline adaptation and improve treatment efficiency. This article is protected by copyright. All rights reserved.

強度変調回転照射法(VMAT)で術後照射を行った2例
木下 留美子, 檜垣 朔, 藤田 祥博, 森 崇, 西岡 健太郎, 橋本 孝之, 青山 英史, 押野 智博, 高橋 将人, 加藤 扶美, 金平 孝博
北海道外科雑誌, 67, 2, 162, 163, 北海道外科学会, Dec. 2022
Japanese

A study on predicting cases that would benefit from proton beam therapy in primary liver tumors of less than or equal to 5 cm based on the estimated incidence of hepatic toxicity
Yusuke Uchinami, Norio Katoh, Ryusuke Suzuki, Takahiro Kanehira, Masaya Tamura, Seishin Takao, Taeko Matsuura, Naoki Miyamoto, Yoshihiro Fujita, Fuki Koizumi, Hiroshi Taguchi, Koichi Yasuda, Kentaro Nishioka, Isao Yokota, Keiji Kobashi, Hidefumi Aoyama
Clinical and Translational Radiation Oncology, 35, 70, 75, Elsevier BV, Jul. 2022, [Peer-reviewed]
Scientific journal

HyperArcを用いた多発性脳転移腫瘍に対する脳定位放射線治療中の各標的の位置ずれに関する検討　　　　　　　　　　　　　　　
山田 亮太, 吉村 高明, 若林 倭, 金平 孝博, 森 崇, 西岡 健太郎, 青山 英史
日本放射線技術学会総会学術大会予稿集, 78回, 161, 162, (公社)日本放射線技術学会, Mar. 2022
Japanese

Comparisons of normal tissue complication probability models derived from planned and delivered dose for head and neck cancer patients
Takahiro Kanehira, Simon van Kranen, Tomas Jansen, Olga Hamming-Vrieze, Abrahim Al-Mamgani, Jan-Jakob Sonke
Radiotherapy and Oncology, 164, 209, 215, Elsevier BV, Nov. 2021, [Peer-reviewed], [Lead author]
Scientific journal

A treatment planning study of urethra-sparing intensity-modulated proton therapy for localized prostate cancer
Takaaki Yoshimura, Kentaro Nishioka, Takayuki Hashimoto, Kazuya Seki, Shouki Kogame, Sodai Tanaka, Takahiro Kanehira, Masaya Tamura, Seishin Takao, Taeko Matsuura, Keiji Kobashi, Fumi Kato, Hidefumi Aoyama, Shinichi Shimizu
Physics and Imaging in Radiation Oncology, 20, 23, 29, Elsevier BV, Oct. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND AND PURPOSE: Urethra-sparing radiation therapy for localized prostate cancer can reduce the risk of radiation-induced genitourinary toxicity by intentionally underdosing the periurethral transitional zone. We aimed to compare the clinical impact of a urethra-sparing intensity-modulated proton therapy (US-IMPT) plan with that of conventional clinical plans without urethral dose reduction. MATERIALS AND METHODS: This study included 13 patients who had undergone proton beam therapy. The prescribed dose was 63 GyE in 21 fractions for 99% of the clinical target volume. To compare the clinical impact of the US-IMPT plan with that of the conventional clinical plan, tumor control probability (TCP) and normal tissue complication probability (NTCP) were calculated with a generalized equivalent uniform dose-based Lyman-Kutcher model using dose volume histograms. The endpoints of these model parameters for the rectum, bladder, and urethra were fistula, contraction, and urethral stricture, respectively. RESULTS: The mean NTCP value for the urethra in US-IMPT was significantly lower than that in the conventional clinical plan (0.6% vs. 1.2%, p < 0.05). There were no statistically significant differences between the conventional and US-IMPT plans regarding the mean minimum dose for the urethra with a 3-mm margin, TCP value, and NTCP value for the rectum and bladder. Additionally, the target dose coverage of all plans in the robustness analysis was within the clinically acceptable range. CONCLUSIONS: Compared with the conventional clinically applied plans, US-IMPT plans have potential clinical advantages and may reduce the risk of genitourinary toxicities, while maintaining the same TCP and NTCP in the rectum and bladder.

Accurate estimation of daily delivered radiotherapy dose with an external treatment planning system
Takahiro Kanehira, Stina Svensson, Simon van Kranen, Jan Jakob Sonke
Physics and Imaging in Radiation Oncology, 14, 39, 42, Apr. 2020, [Peer-reviewed], [Lead author]
Scientific journal

Impact of Real-Time Image Gating on Spot Scanning Proton Therapy for Lung Tumors: A Simulation Study
Takahiro Kanehira, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Yusuke Fujii, Takaaki Fujii, Yoichi M. Ito, Naoki Miyamoto, Tetsuya Inoue, Norio Katoh, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
International Journal of Radiation Oncology Biology Physics, 97, 1, 173, 181, 01 Jan. 2017, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal

Comparing predictors of radiation-induced lymphopenia in various timeframes in NSCLC radiotherapy
Takahiro Kanehira, Hiroshi Taguchi, Jun Sakakibara-Konishi, Norio Katoh, Yusuke Uchinami, Keiji Kobashi, Takayuki Hashimoto, Hidefumi Aoyama, RADIOTHERAPY AND ONCOLOGY, 194, S5012, S5015, May 2024
English, Summary international conference

Effect of early fractional lymphocyte loss on lymphopenia probability models for NSCLC
T. Kanehira, H. Taguchi, N. Katoh, Y. Uchinami, T. Yoshimura, M. Tamura, R. Suzuki, T. Hashimoto, H. Aoyama, Radiotherapy and Oncology, 182, S1909, S1911, May 2023, [Peer-reviewed], [Lead author]
Elsevier BV

Comparison of dose accumulation based on CBCT and CT for lung cancer patients
T. Kanehira, S.R. van Kranen, W.V. Vogel, J. Sonke, Radiotherapy and Oncology, 152, S914, S915, Nov. 2020, [Peer-reviewed], [Lead author]
Elsevier BV

Unsupervised deep learning for fast and accurate CBCT to CT deformable image registration
S.R. Van Kranen, T. Kanehira, R. Rozendaal, J. Sonke, Radiotherapy and Oncology, 133, S267, S268, Apr. 2019, [Peer-reviewed]
Elsevier BV

PO-0993 Uncertainty estimation of dose accumulation with deformable image registration in head and neck region
T. Kanehira, S. Kranen, J. Sonke, Radiotherapy and Oncology, 133, S546, S547, Apr. 2019, [Peer-reviewed], [Lead author]
Elsevier BV

Comparison of NTCP models between using planned and actual delivered dose for head and neck cancer
T. Kanehira, S.R. Van Kranen, O. Hamming-Vrieze, T. Janssen, J.J. Sonke, Radiotherapy and Oncology, 127, S165, S166, Apr. 2018, [Peer-reviewed], [Lead author]
Elsevier BV

Feasibility Study of Using Dual-Energy Cone Beam Computed Tomography (DE-CBCT) in Proton Therapy Treatment Planning
H. Peng, T. Kanehira, S. Takao, T. Matsuura, K. Umegaki, H. Shirato, L. Xing, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 96, 2, E697, E697, Oct. 2016
English, Summary international conference

Feasibility Study of Using a Dual-Energy Cone Beam CT (DECBCT) in Proton Therapy Treatment Planning
H. Peng, T. Kanehira, S. Takao, T. Matsuura, K. Umegaki, H. Shirato, L. Xing, MEDICAL PHYSICS, 43, 6, 3457, 3458, Jun. 2016
English, Summary international conference

Simulation Study of Real-Time-Image Gating On Spot Scanning Proton Therapy for Lung Tumors
T. Kanehira, T. Matsuura, S. Takao, Y. Matsuzaki, Y. Fujii, T. Fujii, N. Miyamoto, T. Inoue, N. Katoh, S. Shimizu, K. Umegaki, H. Shirato, MEDICAL PHYSICS, 43, 6, Jun. 2016
English, Summary international conference

Comparing predictors of radiation-induced lymphopenia in various timeframes in NSCLC radiotherapy　　　　　　　　　　　　　　　
Takahiro Kanehira, Hiroshi Taguchi, Jun Sakakibara-Konishi, Norio Katoh, Yusuke Uchinami, Keiji Kobashi, Takayuki Hashimoto, Hidefumi Aoyama
European Society for Radiotherapy and Oncology (ESTRO), May 2024, English
03 May 2024 - 07 May 2024

肺癌に対する化学放射線治療中のリンパ球減少が全生存率に及ぼす影響　　　　　　　　　　　　　　　
田口大志, 金平孝博, 宮崎, 高柳泰輔, 青山英史
日本放射線腫瘍学会第36回学術大会, Nov. 2023

肺癌に対する化学放射線治療中のリンパ球数予測モデルの開発　　　　　　　　　　　　　　　
宮崎康一, 高柳泰輔, 金平孝博, 田口大志, 青山英史
日本放射線腫瘍学会第36回学術大会, Nov. 2023

Effect of early fractional lymphocyte loss on lymphopenia probability models for NSCLC　　　　　　　　　　　　　　　
T. Kanehira, H. Taguchi, N. Katoh, Y. Uchinami, T. Yoshimura, M. Tamura, R. Suzuki, T. Hashimoto, H. Aoyama
European Society for Radiotherapy and Oncology (ESTRO), May 2023, English
12 May 2023 - 16 May 2023

プランライブラリを用いた膵癌定位放射線治療における日々の線量評価　　　　　　　　　　　　　　　
金平 孝博, 加藤 徳雄, 打浪 雄介, 宮﨑 智彦, 田口 大志, 横川 航平, 鈴木 隆介, 宮本 直樹, 青山 英史
第37回高精度放射線外部照射部会学術大会, 02 Mar. 2023

Comparison of dose accumulation based on CBCT and CT for lung cancer patients　　　　　　　　　　　　　　　
T. Kanehira, S.R. van Kranen, W.V. Vogel, J. Sonke
European Society for Radiotherapy and Oncology (ESTRO), Nov. 2020
28 Nov. 2020 - 01 Dec. 2020

Unsupervised deep learning for fast and accurate CBCT to CT deformable image registration　　　　　　　　　　　　　　　
S.R. Van Kranen, T. Kanehira, R. Rozendaal, J. Sonke
European Society for Radiotherapy and Oncology (ESTRO), Apr. 2019, English
26 Apr. 2019 - 30 Apr. 2019

Uncertainty estimation of dose accumulation with deformable image registration in head and neck region　　　　　　　　　　　　　　　
T. Kanehira, S. Kranen, J. Sonke
European Society for Radiotherapy and Oncology (ESTRO), Apr. 2019
26 Apr. 2019 - 30 Apr. 2019

Comparison of NTCP models between using planned and actual delivered dose for head and neck cancer　　　　　　　　　　　　　　　
T. Kanehira, S.R. Van Kranen, O. Hamming-Vrieze, T. Janssen, J.J. Sonke
European Society for Radiotherapy and Oncology (ESTRO), Apr. 2018
20 Apr. 2018 - 24 Apr. 2018

Simulation Study of Real-Time-Image Gating On Spot Scanning Proton Therapy for Lung Tumors　　　　　　　　　　　　　　　
T. Kanehira, T. Matsuura, S. Takao, Y. Matsuzaki, Y. Fujii, T. Fujii, N. Miyamoto, T. Inoue, N. Katoh, S. Shimizu, K. Umegaki, H. Shirato
American Association of Physicists in Medicine (AAPM), Aug. 2016, English
31 Jul. 2016 - 04 Aug. 2016

臨床医学物理学実習（治療計画）　　　　　　　　　　　　　　　
北海道大学大学院医理工学院
Apr. 2023 - Present

基礎放射線治療物理学　　　　　　　　　　　　　　　
北海道大学大学院医理工学院
Apr. 2023 - Present

臨床医学物理学実習（品質管理）　　　　　　　　　　　　　　　
北海道大学大学院医学研究科
2023 - Present

Medical Physics School　　　　　　　　　　　　　　　
2022 - Present

Jan. 2016 - Present
日本医学物理学会