Two cases of juxtapapillary retinal astrocytic hamartoma: a multimodal imaging study.
Mizuho Mitamura, Satoru Kase, Kiriko Nishiyama-Hirooka, Michiyuki Saito, Susumu Ishida
BMC ophthalmology, 25, 1, 691, 691, 2025年12月16日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND/AIM: Isolated retinal astrocytic hamartoma (IRAH) is a rare, benign retinal tumor that typically occurs without any clinical comorbidities. The clinical diagnosis of IRAH remains a challenge. This study reported on two patients with IRAH in the juxtapapillary region and evaluated their multimodal imaging findings. CASE REPORT: Case 1 involved a 71-year-old woman who presented with a retinal mass adjacent to the superior optic disc in her right eye. Optical coherence tomography (OCT) of the lesion cross-sections revealed thickening of the inner retinal layer, accompanied by low-reflection spots. Fluorescein angiography (FA) revealed hypofluorescence in the early and late phases. Case 2 involved a 37-year-old woman who presented with a whitish retinal tumor on the nasal optic disc in her left eye. She had a medical history of Vogt-Koyanagi-Harada disease approximately 20 years prior. OCT revealed a highly reflective mass with calcification. FA revealed fluorescein leakage from the tumor during the late phase. Laser speckle flowgraphy (LSFG) revealed cold coloration in both cases, indicating poor blood flow within the tumor. Both patients were diagnosed with IRAH, and no marked changes in the clinical characteristics of the tumors were observed during a follow-up of more than 6 months. CONCLUSION: Multimodal imaging, including LSFG, contributed to the clinical diagnosis of juxtapapillary IRAH, characterized by slow and consistent blood flow, consistent with a stable nature.

A case of IgG4-related ophthalmic disease with bone destruction presenting as unilateral painful blepharitis
Yuki Tanaka, Yoshihiro Matsuno, Shinichi Nakazato, Susumu Ishida
International Journal of Ophthalmology, 18, 9, 1812, 1814, Press of International Journal of Ophthalmology (IJO Press), 2025年09月18日
研究論文（学術雑誌）

Clinical characteristics of multiple evanescent white dot syndrome with poor visual prognosis in Japanese patients.
Takayuki Tanaka, Michiyuki Saito, Satoru Kase, Zhenyu Dong, Ryo Ando, Kenichi Namba, Kiriko Nishiyama-Hirooka, Yui Yamashita, Susumu Ishida
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 263, 9, 2551, 2559, 2025年09月, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: Multiple evanescent white dot syndrome (MEWDS) typically resolves spontaneously and is expected to have a favorable visual prognosis. Therefore, the initial manifestations of MEWDS have yet to be well studied. This study aimed to investigate the clinical characteristics of primary and secondary MEWDS patients and evaluate factors responsible for poor visual prognosis. METHODS: The medical records of 36 patients diagnosed with MEWDS between 2004 and 2021 at Hokkaido University Hospital were retrospectively reviewed. The study evaluated patient demographics, clinical characteristics, and multimodal imaging findings. The clinical factors involving final logMAR best-corrected visual acuity (BCVA) were analyzed. In addition, clinical characteristics of secondary MEWDS cases with poor visual prognosis were investigated. RESULTS: Twelve of the 36 patients (33.3%) had active chorioretinal lesions distinct from MEWDS lesions, resulting in a prevalence of secondary MEWDS of 33.3%. Four patients presented with foveal active chorioretinal lesions (11.1%). Retinal atrophy developed in these lesions in all four cases during the follow-up period. Compared to primary MEWDS, secondary MEWDS with foveal involvement of active chorioretinal lesions was associated with significantly worse visual acuity at the initial visit (p = 0.004), and showed a trend toward poorer visual acuity was also observed at the final visit (p = 0.11). In simple linear regression analysis, coexisting foveal involvement of active chorioretinal lesions was significantly associated with worse final logMAR BCVA (p = 0.002). In multiple stepwise linear regression analysis, coexisting foveal involvement (p < 0.001) and male sex (p = 0.03) remained independently associated with poorer visual outcomes. CONCLUSIONS: The presence of foveal active chorioretinal lesions in MEWDS may be associated with poorer visual prognosis. KEY MESSAGE: WHAT IS KNOWN : • Recent reports characterized the clinical aspects of primary and secondary multiple evanescent white dot syndrome (MEWDS), but the visual prognosis of these variants is only slowly unfolding. WHAT IS NEW: • Secondary MEWDS associated with foveal involvement of active chorioretinal lesions had significantly poorer visual acuity at the initial visit and showed a trend toward poorer visual acuity at the final visit compared to primary MEWDS. • In both simple and multiple linear regression analyses, foveal involvement of active chorioretinal lesions was associated with poorer visual outcomes. • The presence of foveal active chorioretinal lesions in MEWDS may be associated with poorer visual prognosis.

When ocular surface treatment fails: exploring neuropathic ocular pain in aqueous-deficient dry eye due to Sjögren's syndrome treated with mirogabalin: a case study.
Yoshiaki Tagawa, Yusuke Aihara, Susumu Ishida
Immunological medicine, 48, 3, 261, 265, 2025年09月, ［国際誌］
英語, 研究論文（学術雑誌）, Dry eye disease can be classified as aqueous-deficient, evaporative and mixed-type. Recently, neuropathic pain has been indicated to be involved in the subjective symptoms of aqueous-deficient dry eye. However, the mechanism underlying neuropathic ocular pain in such patients remains elusive. Here, we present the case of a patient with aqueous-deficient dry eye disease and severe corneal and conjunctival epithelial damage due to Sjögren's syndrome. Despite considerable improvements in ocular surface conditions with local treatments, such as punctal plugs, autologous serum eye drops, rebamipide eye drops, and tacrolimus eye drops, the patient experienced severe ocular pain for two years, which was disproportionate to the objective clinical findings. The pain worsened during the exacerbations of systemic symptom, such as arthritis and interstitial pneumonia, without correlating with the ocular surface findings. The administration of mirogabalin, a neuropathic pain medication, effectively alleviated the patient's subjective ocular pain symptoms. Ocular pain in patients with Sjögren's syndrome is not necessarily linked to an aqueous deficiency or ocular surface findings. It can arise as neuropathic ocular pain due to inflammation spreading to the trigeminal nerve. Given the systemic inflammatory condition and characteristics of the ocular pain, administering neuropathic pain medications should be considered as a treatment option.

Severe Aqueous-Deficient Dry Eye Following Herpes Zoster Ophthalmicus With Periocular Inflammation: A Case Series.
Rina Kanaya, Yoshiaki Tagawa, Kenichi Namba, Mayuko Kimura, Susumu Ishida
Cureus, 17, 8, e90569, 2025年08月, ［国際誌］
英語, 研究論文（学術雑誌）, This series aimed to describe the clinical characteristics and course of severe aqueous-deficient dry eye (ADDE), a condition characterized by tear deficiency and reduced corneal sensation, following ophthalmic herpes zoster infection with periocular inflammation. Four cases of ADDE that developed after ophthalmic herpes zoster infection were retrospectively examined. Clinical data, including disease course, medical history, imaging findings, tear volume assessment, corneal sensitivity testing, and treatment outcomes, were collected. Our patients exhibited severe tear deficiency, significant corneal hypoesthesia, and serious corneal complications, accompanied by persistent ocular pain despite reduced corneal sensation. Imaging studies revealed dacryoadenitis in two cases and suggested severe periocular inflammation in all cases. Persistent superficial punctate keratopathy (SPK) was observed in all patients, with complications including corneal ulcers, perforation, persistent epithelial defects, and filamentary keratitis. Neuropathic pain was believed to contribute to persistent ocular pain. Treatment with topical rebamipide, autologous serum eye drops, punctal plugs, and eyelid closure effectively managed corneal epithelial damage and associated complications. Herpes zoster-induced dacryoadenitis and corneal sensory nerve damage probably contributed to ADDE pathogenesis. Given the potential for severe corneal complications, careful long-term monitoring is crucial in these patients.

Unmasking Photophobia and Blepharospasm Mechanisms: The Role of Optic Chiasm and Trigeminal Nerve Compression in a Giant Pituitary Adenoma Case.
Ayaka Hasegawa, Yoshiaki Tagawa, Yasuhiro Shinmei, Akihiro Shinkai, Susumu Ishida
Cureus, 17, 8, e91148, 2025年08月, ［国際誌］
英語, 研究論文（学術雑誌）, Blepharospasm, characterized by abnormal blinking and sensory hypersensitivity such as photophobia and ocular pain, is thought to arise from pathological sensorimotor integration. We report a rare case of a male teenager with a growth hormone-secreting giant pituitary adenoma compressing both the optic chiasm and bilateral trigeminal nerves. Initially, the patient presented with visual disturbances and bitemporal hemianopia, without photophobia or ocular pain. Following partial tumor resection, which relieved compression of the optic chiasm but not the trigeminal nerves, he developed severe photophobia, deep ocular pain, and bilateral secondary blepharospasm. These symptoms persisted despite pharmacologic interventions, including pregabalin and topical rebamipide. A second surgery, which decompressed the trigeminal nerves, led to the complete resolution of all symptoms. The clinical course suggests that trigeminal nerve compression, particularly of the ophthalmic branch (V1), may induce hypersensitivity states resulting in neuropathic pain, photophobia, and secondary blepharospasm. We hypothesize that initial optic chiasm compression suppressed photophobia by disrupting non-visual photophobia circuits through the suprachiasmatic nuclei to pulvinar nuclei. After decompression, restoration of this pathway unmasked the hypersensitivity induced by ongoing trigeminal compression. The complete resolution of symptoms following trigeminal decompression supports the role of peripheral sensory nerve compression in the pathogenesis of photophobia and secondary blepharospasm. This case provides novel clinical evidence for the interrelationship between the trigeminal and visual pathways in sensorimotor disorders.

Diabetes-Induced Dysregulation of Peripapillary and Macular Neurovascular Units
Mizuho Mitamura, Satoru Kase, Hiroaki Endo, Michiyuki Saito, Satoshi Katsuta, Susumu Ishida
Investigative Ophthalmology & Visual Science, 66, 9, 10, 10, Association for Research in Vision and Ophthalmology (ARVO), 2025年07月03日
研究論文（学術雑誌）

Leucine-Rich Repeat Kinase 2 Promotes Disintegration of Retinal Pigment Epithelial Cell
Yuka Suimon, Moemi Nishimura, Miyuki Murata, Shiho Yoshida, Koichi Yokoi, Zhenyu Dong, Noriyuki Kuno, Shinobu Fujii, Zen-Ichi Tanei, Ichiro Yabe, Kousuke Noda, Susumu Ishida
The American Journal of Pathology, 195, 7, 1294, 1310, Elsevier BV, 2025年07月
研究論文（学術雑誌）

Morphological Changes in the Saw-Tooth Pattern of Cuticular Drusen Associated with Immune Complex-Mediated Membranous Proliferative Glomerulonephritis Type III: A Case Report
Takayuki Tanaka, Satoru Kase, Kiriko Nishiyama-Hirooka, Michiyuki Saito, Susumu Ishida
Case Reports in Ophthalmology, 16, 1, 535, 541, S. Karger AG, 2025年06月25日
研究論文（学術雑誌）, Introduction: Patients with membranoproliferative glomerulonephritis (MPGN) type III may exhibit the saw-tooth pattern of cuticular drusen. This study reports a four-and-a-half-year retrospective time-dependent observation of cuticular drusen associated with immune complex-mediated MPGN type III patients. Case Presentation: A 32-year-old woman was referred for ocular evaluation due to systemic steroids used for nephrotic syndrome caused by immune complex-mediated MPGN type III. She had no ocular symptoms. The initial examination showed that her best-corrected visual acuity (BCVA) was 1.0 oculus uterque (OU). Color fundus photographs revealed pigmentary abnormalities in the macular and perimacular regions OU. Fundus autofluorescence (FAF) images demonstrated numerous tiny dots with a hypoautofluorescent center surrounded by a rim of hyperautofluorescence. Enhanced depth imaging-optical coherence tomography (OCT) revealed triangular morphologic features, represented by a saw-tooth pattern with internal hyporeflectivity. Over 4.5 years, the internal reflectivity of the drusen gradually increased. Moreover, depigmentation and yellow color changes in the macular and perimacular regions worsened, without obvious changes on FAF. Her BCVA remained at 1.0 OU, without new ocular symptoms or cataract progression during the 4.5-year follow-up period. Both eyes had a significant positive correlation between swept-source OCT-based mean internal reflectivity measured by the ImageJ software and the observation period. However, no correlation was found between the estimated glomerular filtration rate (eGFR) and the observation period or between eGFR and mean internal reflectivity. Conclusion: The internal reflectivity of cuticular drusen associated with immune complex-mediated MPGN type III showed time-dependent changes on OCT and worsened depigmentation and yellow color changes in the macular and perimacular regions, independent of renal function.

Pterygium-like conjunctival nevus: a clinicopathological study
Satoru Kase, Kiriko Hirooka, Emi Takakuwa, Susumu Ishida
Canadian Journal of Ophthalmology, 60, 3, e498, e501, Elsevier BV, 2025年06月
研究論文（学術雑誌）

Case Report: Laser speckle flowgraphy in a patient with uveitis due to immune-related adverse events by immune checkpoint inhibitors
Satoru Kase, Yui Yamashita, Satoshi Takeuchi, Susumu Ishida
Frontiers in Oncology, 15, Frontiers Media SA, 2025年05月15日
研究論文（学術雑誌）, Purpose

It remains unknown whether choroidal circulation could be altered at the onset of immune checkpoint inhibitor (ICI) uveitis compared with that before ICI treatment. Herein we report a patient with Vogt-Koyanagi-Harada (VKH) disease-like uveitis in the unaffected eye as an immune-related adverse effect (irAE) due to ICIs for metastatic choroidal melanoma who had received enucleation. Moreover, choroidal circulation and choroidal thickness were measured before and after treatment.

Methods

A 58-year-old man had a medical history of enucleation in his left eye due to choroidal melanoma 6 years ago. Metastatic lesions in the gastrointestinal tracts and lung were found, and then he received ICIs three times. About 1 month later, he suffered from blurred vision and metamorphopsia in his right eye. Choroidal circulation was evaluated by mean blur rate (MBR), a relative value showing choroidal blood velocity on laser speckle flowgraphy. Central choroidal thickness (CCT) was measured on optical coherence tomography.

Results

Since ophthalmic findings revealed VKH-like uveitis, oral prednisolone of 30 mg was given for 2 weeks, which were then tapered. MBR was reduced and CCT increased at the onset of ICI uveitis compared with its baseline and resolution after corticosteroid treatment.

Conclusions

Choroidal circulation was disrupted, possibly due to ICI-induced autoinflammatory reaction to the choroid, which was managed by corticosteroid treatment. The combination of MBR and CCT could be a useful biomarker for managing the patients with VKH-like uveitis by ICIs.

Inter-Relationships Between the Deep Learning-Based Pachychoroid Index and Clinical Features Associated with Neovascular Age-Related Macular Degeneration
Michiyuki Saito, Mizuho Mitamura, Yuki Ito, Hiroaki Endo, Satoshi Katsuta, Susumu Ishida
Journal of Clinical Medicine, 14, 9, 3245, 3245, MDPI AG, 2025年05月07日
研究論文（学術雑誌）, Background/Objectives: To investigate the impact of pachychoroid on the clinical features of neovascular age-related macular degeneration (nAMD) in Japan using the deep learning-based Hokkaido University pachychoroid index (HUPI), which has a high discriminative ability for pachychoroid. Methods: This retrospective observational study examined 124 eyes of 111 treatment-naïve nAMD patients, including 44 eyes with type 1 macular neovascularization (MNV), 26 eyes with type 2 MNV, and 54 eyes with polypoidal choroidal vasculopathy (PCV). HUPI was calculated for each eye from EDI-OCT choroidal images using our modified LeNet that had learned the image patterns of pachychoroid. Differences in HUPI between nAMD types and inter-relationships between nAMD parameters, including HUPI, were evaluated. Results: The mean HUPI was 0.53 ± 0.30 for type 1 MNV, 0.33 ± 0.23 for type 2 MNV, and 0.61 ± 0.3 for PCV, with significant differences between any two of the three groups (p < 0.05, for each). Round-robin multiple regression analysis for nAMD parameters showed the close associations of the HUPI with choroidal vascular hyperpermeability (CVH) and subretinal fluid (SRF) (p = 0.017 and p < 0.001 for each) and the clear division of nAMD parameters into the following two groups: one including intraretinal fluid and type 1 and type 2 MNV and the other including SRF, CVH, polypoidal lesions, and HUPI. Conclusions: HUPI revealed that eyes with type 1 MNV and PCV had more pachychoroid-like features than eyes with type 2 MNV. HUPI was tightly associated with CVH and SRF but not MNV per se in nAMD parameters, reinforcing the pathoetiological concept of differentiating pachychoroid from typical nAMD.

Aggressive Orbital Dedifferentiated Liposarcoma With Osseus Components in a Young Woman
SATORU KASE, TAKU MAEDA, NORIYUKI OTSUKA, YUKA SUIMON, SUSUMU ISHIDA
Cancer Diagnosis & Prognosis, 5, 3, 404, 409, International Institute of Anticancer Research, 2025年05月03日
研究論文（学術雑誌）, Background/Aim:Dedifferentiated liposarcoma (DDLS) is a rare but aggressive subtype of liposarcoma that arises in soft tissues. In orbital liposarcoma, malignant transformation from well-differentiated to DDLS typically takes at least a year. We herein report a case of a young female with an aggressive DDLS, that developed from an orbital lipoma within one year.Case Report:A 25-year-old woman presented with left upper eyelid swelling. MRI revealed abnormal adipose tissue in the medial orbit. The excised tissue was diagnosed as an orbital lipoma. The eyelid swelling recurred three months later, and the orbital tumor enlarged. An additional resection was performed, which again revealed a lipoma without malignant features. Three months later, the swelling worsened, and tumor resection confirmed well differentiated liposarcoma with a Ki-67 labeling index of 10%. Two months later, CT imaging depicted calcified lesions within the tumor. The patient subsequently underwent orbital exenteration followed by proton beam radiation. Histopathological examination of the exenterated tissue revealed DDLS with extensive osseous components. The Ki-67 labeling index exceeded 50%.Conclusion:Ocular oncologists should pay attention to the possibility of rapid malignant transformation in DDLS in primary orbital liposarcoma.

Sex Differences in Age-Related Changes in Retinal Arteriovenous Area Based on Deep Learning Segmentation Model
Mizuho Mitamura, Michiyuki Saito, Kanae Fukutsu, Zhenyu Dong, Ryo Ando, Satoru Kase, Kousuke Noda, Ryosuke Shiba, Naoki Isogai, Mitsuru Dohke, Manabu Kase, Susumu Ishida
Ophthalmology Science, 5, 3, 100719, 100719, Elsevier BV, 2025年05月
研究論文（学術雑誌）

AI-based analysis of surgical outcomes in vitrectomy with and without cystotomy for refractory cystoid diabetic macular edema
Mizuho Mitamura, Michiyuki Saito, Kiriko Nishiyama-Hirooka, Zhenyu Dong, Ryo Ando, Satoru Kase, Susumu Ishida
Scientific Reports, 15, 1, Springer Science and Business Media LLC, 2025年04月26日
研究論文（学術雑誌）

Transvitreal endoresection of peripheral exudative hemorrhagic chorioretinopathy: a clinicopathological study
Satoru Kase, Ai Shimizu, Susumu Ishida
BMC Ophthalmology, 25, 1, Springer Science and Business Media LLC, 2025年04月22日
研究論文（学術雑誌）

Choroidal blood flow velocity and resistance in inferior posterior staphyloma using a novel superpixel technique in laser speckle flowgraphy
Michiyuki Saito, Mizuho Mitamura, Koichi Yokoi, Kiriko Hirooka, Dong Zhenyu, Ryo Ando, Satoru Kase, Susumu Ishida
Scientific Reports, 15, 1, Springer Science and Business Media LLC, 2025年03月26日
研究論文（学術雑誌）

Retinal Arteriovenous Information Improves the Prediction Accuracy of Deep Learning–Based baPWV Index From Color Fundus Photographs
Michiyuki Saito, Mizuho Mitamura, Kanae Fukutsu, Dong Zhenyu, Ryo Ando, Satoru Kase, Satoshi Katsuta, Susumu Ishida
Investigative Ophthalmology & Visual Science, 66, 2, 63, 63, Association for Research in Vision and Ophthalmology (ARVO), 2025年02月25日
研究論文（学術雑誌）

Differences in Artificial Intelligence-Based Macular Fluid Parameters Between Clinical Stages of Diabetic Macular Edema and Their Relationship with Visual Acuity
Mizuho Mitamura, Michiyuki Saito, Kiriko Hirooka, Zhenyu Dong, Ryo Ando, Satoru Kase, Susumu Ishida
Journal of Clinical Medicine, 14, 3, 1007, 1007, MDPI AG, 2025年02月05日
研究論文（学術雑誌）, Background/Objectives: The aim of this study was to determine artificial intelligence-based macular fluid (MF) parameters in diabetic macular edema (DME) with optical coherence tomography (OCT) and examine stage-by-stage differences in MF parameters and their relationship with best-corrected visual acuity (BCVA). Methods: This study enrolled 104 eyes with treatment-naïve DME. Intraretinal fluid (IRF) and subretinal fluid (SRF) were detected in horizontal OCT images based on the “Hokkaido University MF segmentation model” when DME was first observed together with BCVA testing. The MF area, the mean brightness, and the variance of brightness were compared between mild or moderate non-proliferative diabetic retinopathy (mNPDR, n = 33), severe NPDR (sNPDR, n = 52), and PDR eyes (n = 19). Correlations between logMAR BCVA and MF parameters were also examined. Results: All the MF parameters tended to increase with DR stages. Especially, the mean brightness of IRF was significantly greater in PDR than in mNPDR. The variance of brightness of IRF increased in sNPDR compared to mNPDR, whereas that of SRF increased in PDR compared to sNPDR. LogMAR BCVA showed positive correlations with MF areas and the variance of brightness of SRF. Conclusions: The qualitative and quantitative MF parameters may be useful for better understanding DME pathogenesis according to DR progression.

Lacrimal gland pleomorphic adenoma: two referral center analyses in Hokkaido, Japan.
Mizuho Mitamura, Satoru Kase, Yasuo Suzuki, Takatoshi Sakaguchi, Yuka Suimon, Manabu Kase, Susumu Ishida
International journal of ophthalmology, 18, 12, 2385, 2389, 2025年, ［国際誌］
英語, 研究論文（学術雑誌）, AIM: To evaluate the clinical features of primary lacrimal gland pleomorphic adenoma (LGPA). METHODS: This was a 2-center, retrospective, observational study of primary LGPA patients who underwent tumor resection. Ophthalmic examinations and orbital computed tomography (CT) and/or magnetic resonance imaging (MRI) were performed. RESULTS: Totally 18 patients (10 males and 8 females, mean age 56.3±13.8y) were enrolled. Initial symptoms were unilateral proptosis in 8 patients, diplopia in 3 patients, and pressure sensation and no chief complaint in 2 patients each. The best-corrected visual acuity of the affected eye was 0.26±0.44 logMAR, and the intraocular pressure (IOP) of the affected and healthy eyes was 20.1±9.9 and 15.8±4.3 mm Hg, respectively. The difference in degree of proptosis between the affected and healthy eyes was 4.1±2.2 mm based on the Hertel ocular protrusion meter. One case had a history of breast cancer. Seventeen of 18 patients with an orbital lacrimal gland origin underwent total tumor excision by anterior/lateral orbitotomy. CONCLUSION: Orbital LGPA can complicate IOP elevation, and require total tumor excision by orbitotomy. In rare cases, systemic malignancy may complicate LGPA, and in such cases total removal of the lacrimal gland tumor should be considered at the initial surgery.

Spontaneously Diabetic Torii Fatty Rat Shows Early Stage of Diabetic Retinopathy Characterized by Capillary Changes and Inflammation
Kasumi Kikuchi, Miyuki Murata, Yasushi Kageyama, Masami Shinohara, Tomohiko Sasase, Kousuke Noda, Susumu Ishida
Journal of Diabetes Research, 2025, 1, Wiley, 2025年01月
研究論文（学術雑誌）, Purpose: The Spontaneously Diabetic Torii (SDT) fatty rat is an animal model of obese Type 2 diabetes. We previously reported that the SDT fatty rats develop diabetic cataracts. This study aimed to elucidate early diabetic changes in the retina of the SDT fatty rats.

Materials and Methods: The retinal thickness, capillary diameter, and pericyte/endothelial cell (P/E) ratio were assessed in the male SDT fatty rats and Sprague–Dawley (SD) rats at 24 weeks of age. Immunostaining was performed to assess the intercellular adhesion molecule‐1 (ICAM‐1) and vascular cell adhesion molecule‐1 (VCAM‐1) levels in the retinal capillaries. DNA microarray analysis was performed to detect inflammation‐associated molecules in the retina of the SDT fatty rats. Real‐time PCR and Magnetic Luminex Assay were performed to validate the results.

Results: The retinal thickness in the SDT fatty rats was significantly greater than that in SD rats. The capillary diameter in the retina of the SDT fatty rats was significantly higher than that of SD rats. The P/E ratio in the SDT fatty rats was significantly lower than that in SD rats. ICAM‐1 and VCAM‐1 were observed in the retinal vessels of the SDT fatty rats. The levels of mRNA and protein of Mcp1, Il1b, Icam1, and Tnf were upregulated in the retinal tissues of the 24‐week‐old SDT fatty rats.

Conclusions: Our study demonstrated that the SDT fatty rats exhibited early diabetic retinal changes, suggesting that the SDT fatty rats may be useful in research on the pathogenesis of early human diabetic retinopathy.

A case of uveoscleral mucosa-associated lymphoid tissue lymphoma with secondary angle-closure glaucoma.
Mizuho Mitamura, Satoru Kase, Yuka Suimon, Kenjiro Kato, Hiromi Kanno-Okada, Susumu Ishida
BMC ophthalmology, 24, 1, 549, 549, 2024年12月27日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND/AIM: Mucosa-associated lymphoid tissue (MALT) lymphomas occur in not only the ocular adnexa, but rarely in the sclera or uvea. Histopathological confirmation contributes to a better understanding of the pathogenesis and treatment. We report a case of uveoscleral MALT lymphoma with angle-closure glaucoma. CASE REPORT: A 73-year-old man was referred to our hospital for a detailed examination of a choroidal mass oculus sinister (OS). At the initial examination, best-corrected visual acuity (BCVA) was 0.4 OS, intraocular pressure was 37 mmHg OS, the left eye had a narrow angle with anterior chamber inflammation. Optical coherence tomography (OCT) showed marked choroidal elevation. Anterior segment OCT showed tumor invasion into the inferior angle and ultrasound B-mode echography demonstrated choroidal thickening and a banded hypoechoic area posterior to the eye. Magnetic resonance imaging showed isointensity in the tumor on heterogeneous enhancement on gadolinium contrast-T1WI. A tumor biopsy of the left sclera was performed one month after the initial visit. Based on pathological findings, he was diagnosed with uveoscleral MALT lymphoma. Two months after the initial visit, left eye irradiation was performed. Nine months after the initial visit, the tumor was in remission with open angle. CONCLUSION: Angle-closure glaucoma caused by the uveoscleral MALT lymphoma was treated with radiotherapy, leading to IOP normalization as well as tumor remission.

A Case of Metastatic Iris Tumor from Adenocarcinoma of the Cecum Diagnosed by Combined Tumor Markers in Aqueous Humor and Fine Needle Aspiration Cytology
Mizuho Mitamura, Satoru Kase, Yuka Suimon, Yamato Hashimoto, Ryoko Watanabe, Yoshihiro Matsuno, Susumu Ishida
Case Reports in Oncology, 18, 1, 29, 34, S. Karger AG, 2024年12月24日
研究論文（学術雑誌）, Introduction: The diagnosis of metastatic iris tumor is made by a fine-needle aspiration biopsy of part of the solid component of the tumor and tumor cells seeded in the anterior chamber; however, sometimes the diagnosis is not made due to insufficient sample volumes. We report a case of metastatic iris tumor in which measurement of tumor marker levels in the aqueous humor together with fine needle aspiration cytology contributed to the diagnosis. Case Report: An 80-year-old Japanese woman was referred to our hospital because of an iris mass. Six months before the initial visit, the patient was diagnosed with adenocarcinoma of the cecum. Slit-lamp microscopy revealed an elevated iris mass. Fine-needle aspiration cytology suggested adenocarcinoma. The carcinoembryonic antigen (CEA) level in the anterior chamber was 5,716.1 ng/mL, and serum CEA level measured on the same day were 678.5 ng/mL. These data indicated CEA levels synchronously elevated in both anterior chamber and serum. Based on aspiration cytology and high CEA levels of anterior chamber, she was diagnosed with metastatic iris tumor derived from adenocarcinoma of the cecum. One month after the initial visit, right eye irradiation was performed for metastatic iris tumor. Conclusions: Measurement of tumor marker levels in the aqueous humor, together with fine needle aspiration cytology of the tumor, contributes to the diagnosis of metastatic iris tumors.

Wide-field indocyanine green fluorescein angiography findings in inferior posterior staphyloma
Koichi Yokoi, Michiyuki Saito, Mizuho Mitamura, Susumu Ishida
Graefe's Archive for Clinical and Experimental Ophthalmology, 263, 4, 1189, 1192, Springer Science and Business Media LLC, 2024年12月15日
研究論文（学術雑誌）

Clinicopathologic features of conjunctival MALT lymphomas refractory to radiation therapy.
Yuka Suimon, Satoru Kase, Rumiko Kinoshita, Susumu Ishida
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 59, 5, e501-e509, 2024年10月, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVE: Clinicopathologic features of patients with limited-stage mucosa-associated lymphoid tissue (MALT) lymphoma refractory to radiotherapy have not been fully elucidated. This study aimed to elucidate clinicopathologic features of localized conjunctival MALT lymphoma concerning radiosensitivity by analyzing cell proliferation and expression of mismatch repair proteins. METHODS: We enrolled 26 patients with localized conjunctival MALT lymphoma treated with radiotherapy from November 2007 to March 2020. Monoclonal immunoglobulin H gene rearrangement was tested in addition to histopathologic evaluation. Thirty-six specimens were immunostained with antibodies to Ki-67 and MutL protein homologue 1 (MLH1), MutS protein homologue 2 (MSH2), and MutS protein homologue 6 (MSH6). Positive rates under a high-power field at a hot spot were counted manually. RESULTS: After radiotherapy, 21 patients showed clinical disappearance of the tumour without recurrence (effective group). Three patients showed temporary disappearance of the tumour, which later recurred (relapse group). Two patients did not show disappearance of the tumour (ineffective group). The 2 ineffective patients were young, had bilateral lesions, and received x-ray beam therapy. The mean positive rates of Ki-67, MLH1, MSH2, and MSH6 were higher in tumours with complete remission (CR) than in those without CR (23.4% ± 4.0% and 18.7% ± 4.7%, 14.7% ± 2.3% and 7.1% ± 3.7%, 23.9% ± 4.7% and 14.4% ± 5.2%, and 11.5% ± 3.2% and 5.4% ± 2.2%; p > 0.05 for each, respectively). CONCLUSIONS: A few patients could not achieve CR following radiotherapy, whereas there were no significant differences in proliferation activity and mismatch repair proteins between tumours with and without CR.

Grad-CAM-Based Investigation into Acute-Stage Fluorescein Angiography Images to Predict Long-Term Visual Prognosis of Branch Retinal Vein Occlusion
Michiyuki Saito, Mizuho Mitamura, Mayuko Kimura, Yuki Ito, Hiroaki Endo, Satoshi Katsuta, Manabu Kase, Susumu Ishida
Journal of Clinical Medicine, 13, 17, 5271, 5271, MDPI AG, 2024年09月05日
研究論文（学術雑誌）, Background/Objectives: The purpose of this study was to analyze relevant areas in acute-stage fluorescein angiography (FA) images, predicting the long-term visual prognosis of branch retinal vein occlusion (BRVO) based on gradient-weighted class activation mapping (Grad-CAM). Methods: This retrospective observational study included 136 eyes with BRVO that were followed up for more than a year post-FA. Cropped grayscale images centered on the fovea (200 × 200 pixels) were manually pre-processed from early-phase FA at the acute phase. Pairs of the cropped FA images and the best-corrected visual acuity (BCVA) in remission at least one year post-FA were used to train a 38-layer ResNet with five-fold cross-validation. Correlations between the ResNet-predicted and true (actually measured) logMAR BCVAs in remission, and between the foveal avascular zone (FAZ) area measured by ImageJ (version 1.52r) from FA images and true logMAR BCVA in remission were evaluated. The heat maps generated by Grad-CAM were evaluated to determine which areas were consumed as computational resources for BCVA prediction. Results: The correlation coefficient between the predicted and true logMAR BCVAs in remission was 0.47, and that between the acute-stage FAZ area and true logMAR BCVA in remission was 0.42 (p < 0.0001 for both). The Grad-CAM-generated heat maps showed that retinal vessels adjacent to the FAZ and the FAZ per se had high selectivity (95.7% and 62.2%, respectively). Conclusions: The Grad-CAM-based analysis demonstrated FAZ-neighboring vessels as the most relevant predictor for the long-term visual prognosis of BRVO.

Acute acquired comitant esotropia associated with Lhermitte–Duclos disease: a case report
Junya Ota, Ryo Ando, Hiroaki Motegi, Hirokazu Sugino, Tomoko Mitsuhashi, Susumu Ishida
Journal of Medical Case Reports, 18, 1, Springer Science and Business Media LLC, 2024年08月11日
研究論文（学術雑誌）

Giant conjunctival melanoma with rich vascularization causing persistent bleeding.
Satoru Kase, Yuka Suimon, Mizuho Mitamura, Hiromi Kanno-Okada, Susumu Ishida
Molecular and clinical oncology, 21, 2, 53, 53, 2024年08月, ［国際誌］
英語, 研究論文（学術雑誌）, The present study reported a rare case of persistent bleeding caused by conjunctival melanoma containing abundant vascular channels. A 44-year-old Japanese woman presented with a left upper eyelid nodule in February 2023. A pigmented conjunctival mass was present in the upper palpebral conjunctiva. Enhanced computed tomography demonstrated marked enhancement in the left eyelid in the artery phase, indicating hemangioma. The patient suffered blunt trauma to the face in May 2023 and continuous bleeding occurred. Doctors in the emergency room attempted hemostasis by diathermy and suture, but the bleeding could not be stopped. The patient eventually underwent emergent orbital exenteration of the left eye. At high magnification of the histology sample of the bleeding site, small-to-large vascular channels with various vascular lumens made up of endothelial cells within the conjunctival melanoma tissue could be observed. The tumor cells were positive for SOX10, Melan A, S100 and HMB45. We herein propose a novel variant of conjunctival melanoma with rich vascularization, clinically causing persistent bleeding.

Stratified choroidal vascular structure in treatment-naïve diabetic retinopathy.
Hiroaki Endo, Satoru Kase, Mitsuo Takahashi, Yuki Ito, Shozo Sonoda, Tomonori Sakoguchi, Taiji Sakamoto, Satoshi Katsuta, Susumu Ishida, Manabu Kase
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2024年06月19日, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVE: To analyze the anatomical choroidal vascular layers in topical treatment-naïve diabetic retinopathy (DR) eyes. DESIGN: A retrospective, clinical case-control study. METHODS: A total of 328 eyes from 228 patients with treatment-naive DR and 192 eyes matched for axial length from 174 healthy controls were enrolled in the study. Choroidal structure was quantitatively analyzed using enhanced depth imaging optical coherence tomography (EDI-OCT). Each choroidal vascular layer was divided into the choriocapillaris, Sattler's layer, and Haller's layer, and then the choroidal area (CA), luminal area (LA), stromal area (SA), and central choroidal thickness (CCT) were calculated using binarization techniques. The ratio of LA to CA was defined as the L/C ratio. RESULTS: In the choriocapillaris, CA was significantly lower in the mild/moderate non-proliferative DR (mNPDR) group than in the control group, and SA was significantly higher in all DR groups (each P < 0.01). The L/C ratio was significantly lower in all DR groups than controls (P < 0.01). In Sattler's layer, CA, LA, and SA were significantly higher in the severe NPDR (sNPDR) and PDR groups than in the control group (P < 0.01). In Haller's layer, the L/C ratio was significantly high among the PDR groups (P < 0.05). CONCLUSIONS: The choroidal parameters of DR patients by the binarization method were associated with the stage of DR, in which the choriocapillaris lumen decreased in all the DR stages. The expansion of CA seen in more advanced DR eyes mainly resulted from changes in the Sattler's and Haller's layers.

A case of choroidal melanocytoma treated by transscleral resection: A clinicopathological study.
Mizuho Mitamura, Satoru Kase, Yuka Suimon, Hiromi Kanno-Okada, Susumu Ishida
American journal of ophthalmology case reports, 34, 102043, 102043, 2024年06月, ［国際誌］
英語, PURPOSE: Choroidal melanocytoma is a rare benign melanocytic tumor. We report a case of choroidal melanocytoma that was definitively diagnosed by histopathological findings after local resection. OBSERVATION: A 71-year-old female complained of blurred vision in her left eye. Her best-corrected visual acuity (BCVA) was 1.0. A dark-brown elevated lesion, measuring 5 papilla-diameter was found in the periphery of the fundus in her left eye. The mass showed hyperfluorescence on fluorescein angiography, early hypofluorescence and late hyperfluorescence on indocyanine green angiography. B-mode echography indicated the mass was originated from the choroid. Orbital magnetic resonance imaging showed isointense signal intensity on T1-weighted images (WI) and hypointense signal intensity on T2-WI, and poor Gadolinium enhancement on T1WI. The tumor was suspected to be melanocytoma, but it was difficult to differentiate from malignant melanoma. Transscleral tumor resection combined with 25-gauge vitrectomy was performed. Histopathological examinations led to the diagnosis of choroidal melanocytoma. Two years after local resection, her BCVA was 1.0 with no tumor recurrence. CONCLUSIONS/IMPORTANCE: Local resection was useful as a diagnostic treatment for choroidal tumors confined to the periphery of the fundus that were difficult to clinically differentiate from malignant melanoma.

Rationale and Design of VOYAGER: Long-term Outcomes of Faricimab and Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema in Clinical Practice
Robyn Guymer, Clare Bailey, Voraporn Chaikitmongkol, Usha Chakravarthy, Varun Chaudhary, Robert P. Finger, Roberto Gallego-Pinazo, Adrian Koh Hock Chuan, Susumu Ishida, Monica Lövestam-Adrian, Mariacristina Parravano, Jose D. Luna Pinto, Steffen Schmitz-Valckenberg, Veeral Sheth, Eric H. Souied, Gloria C. Chi, Frank Gilberg, Carl Glittenberg, Stefan Scheidl, Monica Bengus
Ophthalmology Science, 4, 3, 100442, 100442, Elsevier BV, 2024年05月
研究論文（学術雑誌）

Effects of age and axial length on choroidal stratified structure in normal eyes.
Yuki Ito, Hiroaki Endo, Satoru Kase, Mitsuo Takahashi, Shozo Sonoda, Tomonori Sakoguchi, Taiji Sakamoto, Susumu Ishida, Manabu Kase
Scientific reports, 14, 1, 2527, 2527, 2024年01月30日, ［国際誌］
英語, 研究論文（学術雑誌）, To quantify the choroidal structures of normal eyes by optical coherence tomography (OCT)-based binarization and evaluate the relationships among age, refractive power, and ocular axial length. This was a retrospective observational study. One hundred and eighty nine eyes of 189 subjects without ocular diseases were examined by enhanced depth imaging (EDI)-OCT. A choroidal OCT horizontal image with a width of 1500 μm centered on the fovea was binarized. The lumen, stroma, and total choroidal area in the choriocapillaris (CC), Sattler's layer (SL), and Haller's layer (HL) were measured, and the ratio of the luminal area to total choroidal area (L/C ratio) was calculated. Multiple regression analysis was performed for choroidal parameters in each choroidal layer and for age, refractive power, and ocular axial length. Multiple regression analysis showed that an older age was significantly correlated with a lower choroidal area and the L/C ratio in all choroidal layers (each P < 0.05). A Long axial length was significantly associated with lower SL and HL (P < 0.05), but not with refractive power. In the choroid of normal eyes, age-related decreases in the choroidal area and L/C ratio were associated with all choroidal layers, and elongation of the axial length was associated with thinning of SL and HL.

Multimodal Imaging, Including Laser Speckle Flowgraphy: A Case of Retinal Metastasis.
Mizuho Mitamura, Satoru Kase, Susumu Ishida
Cancer diagnosis & prognosis, 4, 4, 539, 543, 2024年, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND/AIM: Intraocular metastases of systemic cancer are most frequently located in the choroid, followed by the iris and ciliary body, while retinal metastases are extremely rare. Here we present a case of retinal metastasis and analyze multimodal imaging. CASE REPORT: A 66-year-old woman with a medical history of breast cancer 5 years earlier was referred to our Department struggling with blurry vision in her right eye. At initial examination, her best-corrected visual acuity (BCVA) was 1.0 oculus dexter (OD). Fundus examination revealed a yellowish elevated lesion with irregular surface, measuring 2 papillary diameters, along with serous retinal detachment (SRD) on the temporal side of the optic disc. Optical coherence tomography showed SRD with an isointense nodule extending across all retinal layers. Fluorescein angiography showed hyperfluorescence and vigorous fluorescence leakage inside the tumor in the early and late phases, respectively. Indocyanine green angiography depicted feeder and drainage vessels within the mass. Laser speckle flowgraphy (LSFG) showed a cold signal inside the tumor. Based on these clinical findings, the mass was diagnosed as a retinal metastasis. Eight days after the initial visit, the patient underwent external beam radiation to the right eye. One month after the initial diagnosis, her BCVA was 0.7 OD, the tumor was localized, and SRD had decreased. LSFG indicated vascular remodeling with marginally warmer signals in the tumor. CONCLUSION: LSFG of the retinal metastasis showed a cold signal, suggesting low tumor blood flow velocity and that the tumor may have grown slowly. LSFG findings are likely to play a supportive role in clinical diagnosis and contribute to better understanding of pathogenesis in juxtapapillary tumors.

Z-shaped incision without epithelial resection in pterygium surgery.
Satoru Kase, Shinki Chin, Susumu Ishida
International journal of ophthalmology, 17, 7, 1262, 1266, 2024年, ［国際誌］
英語, 研究論文（学術雑誌）, AIM: To introduce a novel surgical technique using a Z-shaped incision without epithelial resection in ophthalmic pterygia. METHODS: This was a prospective study. During pterygium surgery, all proliferative tissues were separated from the cornea and conjunctiva without resection of the tissues. The unaffected conjunctiva was incised in a Z-shape. The upper (or lower) conjunctival flap was sutured to the lower (or upper) normal conjunctiva on the limbal sclera, while the proliferative tissue was sutured to the upper conjunctiva (or lower) near the fornix. RESULTS: Ten patients with pterygia were eligible for this study. Eight patients with primary pterygia and 2 with recurrent pterygia were included. The age of patients at surgery ranged from 47 to 90y (average: 71.9y). Five patients each showed right and left-sided pterygia. The postoperative follow-up periods were from 8 to 78mo (average: 25.0mo). The surgery was successfully conducted and wounds were favorably reconstructed in all patients. The proliferative tissues sutured to the normal conjunctiva showed palor and attenuated neovessles, and never showed re-growth after surgery. Nine patients did not show recerrence. Recerrent pterygium was noted in 1 patient, but additional treatments were not required. CONCLUSION: The procedure involves the reconstruction of pterygial tissue and normal conjunctiva using a Z-shaped incision. The scleral limbal wound can be covered with non-affected conjunctiva without any excision of conjunctival epithelia in patients with primary or recurrent pterygia.

Clinicopathological findings in refractory diabetic macular edema: A case report.
Takayuki Tanaka, Satoru Kase, Michiyuki Saito, Ikuyo Hirose, Miyuki Murata, Emi Takakuwa, Susumu Ishida
Biomedical reports, 20, 1, 13, 13, 2024年01月, ［国際誌］
英語, The present study describes the case of a patient with refractory diabetic cystoid macular edema who underwent vitrectomy with en bloc removal of the cystoid lesion component. The current study also performed histopathological and immunohistochemical analyses of the cystoid lesion component to assess fibrin/fibrinogen and advanced glycation end-products (AGEs) immunoreactivity. A 69-year-old Japanese man presented with visual loss in the left eye due to residual cystoid macular edema (CME) refractory to anti-vascular endothelial growth factor therapy. Best-corrected visual acuity was 1.2 in the right eye (OD) and 0.5 in the left eye (OS). Fundus examination showed dot hemorrhages and hard exudates in the peri-macular region with pan-retinal photocoagulation scars in both eye. Swept-source optical coherence tomography revealed CME with slight hyperreflectivity in the cyst OS. A total of 3 months after the initial visit, pars plana vitrectomy was performed, and the translucent solidified component within the cystoid lesion was isolated. Histopathologically, the excised component was elliptical in shape, measuring 0.7x0.4 mm and exhibited homogeneous eosinophilic material without cellular components. No membranous structure was observed surrounding the component. Immunohistochemistry demonstrated that the tissue was positive for fibrin/fibrinogen and weakly positive for AGEs, but was negative for glial fibrillary acidic protein, type 1 collagen and receptor for AGEs. To the best of our knowledge, the present case report is the first to histopathologically examine the contents of refractory CME, and to immunohistochemically demonstrate that fibrin in diabetic CME may be post-translationally modified by AGEs. These results suggested that fibrin in CME may escape degradation by plasmin due to post-translational modifications.

正常眼圧緑内障の経過中に抗AQP4抗体陽性視神経炎を発症した一例
桂野 水那, 新明 康弘, 廣岡 季里子, 新海 晃弘, 中村 佳代子, 林 一彦, 石田 晋
神経眼科, 40, 4, 364, 370, 日本神経眼科学会, 2023年12月25日, ［査読有り］
日本語, 研究論文（学術雑誌）, 56歳女性．19年前より両眼の正常眼圧緑内障の診断で前医にて抗緑内障点眼治療を受けていたが，4日前から左眼の眼球運動痛と急激な視野狭窄を自覚し，北海道大学病院を紹介された．視力は右（1.2），左（0.8），眼圧は両眼9 mmHg．右眼の視野検査では緑内障様の鼻側上方の沈下，左眼では高度な周辺部視野欠損と傍中心暗点が認められた．光干渉断層計の網膜内層解析では左眼後極に広範囲の菲薄化と右眼に弓状の菲薄化がみられた．造影MRIで左視神経の増強効果を認め，さらに抗アクアポリン（AQP）4抗体が陽性であったことから抗AQP4抗体陽性視神経炎と診断した．ステロイドパルス治療2クールと免疫グロブリン大量静注療法を施行し，左眼の周辺部視野欠損は改善した．緑内障と思われる経過中でも，眼圧上昇なしに急激に視野狭窄が悪化した場合，視神経炎の合併を念頭におき，抗AQP4抗体の測定を行うべきである．

RETINAL HYPOPERFUSION DETECTED BY WIDE-FIELD OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY IN A CASE OF RETINAL RACEMOSE HEMANGIOMA.
Mizuho Mitamura, Kousuke Noda, Satoru Kase, Kiriko Hirooka, Susumu Ishida
Retinal cases & brief reports, 17, 6, 723, 727, 2023年11月01日, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: Retinal racemose hemangioma is a rare, unilateral, nonhereditary, arteriovenous malformation characterized by the appearance of dilated and tortuous retinal vessels. Retinal racemose hemangioma can develop complications associated with retinal ischemia, such as vitreous hemorrhage, retinal vein occlusion, and neovascular glaucoma. Here, a case of retinal racemose hemangioma with retinal hypoperfusion detected by wide-field swept-source optical coherence tomographic angiography was reported, which was not unambiguously illustrated by fluorescein angiography. METHODS: Case report. RESULTS: A 57-year-old woman was referred to our hospital for the evaluation of severe retinal vascular tortuosity, dilation, and retinal hemorrhages in the left eye. Fundus examination revealed arteriovenous communications temporal to the fovea and multiple microaneurysms surrounded by retinal hemorrhages at the midperipheral temporal fundus. In fluorescein angiography, multiple hyperfluorescent lesions with leakage corresponding to microaneurysms were observed in the temporal and lower midperipheral areas; however, nonperfused areas were apparently absent. By contrast, wide-field optical coherence tomographic angiography clearly showed low-density retinal capillaries in the superotemporal quadrant in comparison with those in the inferotemporal quadrant. CONCLUSION: Wide-field optical coherence tomographic angiography detected sparse retinal capillaries, which were not well illustrated by fluorescein angiography, in a patient with retinal racemose hemangioma. This indicates the presence of low-grade retinal hypoperfusion caused by altered retinal hemodynamics, potentially leading to ischemia-related retinal disorders during a prolonged course, in patients with clinically quiescent retinal racemose hemangioma.

A case of tubulointerstitial nephritis and uveitis syndrome accompanied by subclinical choroiditis.
Takuya Arita, Kenichi Namba, Daiju Iwata, Kayo Suzuki, Yo Ogino, Kazuomi Mizuuchi, Miki Hiraoka, Nobuyoshi Kitaichi, Susumu Ishida
BMC ophthalmology, 23, 1, 424, 424, 2023年10月20日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Tubulointerstitial nephritis and uveitis (TINU) syndrome is an uveits characterized by complications of idiopathic acute tubulointerstitial nephritis, and most cases present only anterior uveitis. We report a case of TINU syndrome in which the presence of choroiditis was revealed by multimodal imaging. CASE PRESENTATION: A 12-year-old male visited our hospital with a 6-day history of ocular pain and hyperemia. Conjunctival and ciliary injections, 1 + flare and 3 + cells of anterior chamber inflammation with mutton fat keratic precipitates were observed in both eyes (OU), together with redness and swelling of the optic disc OU. Laboratory tests showed slightly high levels of soluble IL-2R and serum β2 microglobulin and markedly high levels of urinary β2 microglobulin. The diagnosis of probable TINU syndrome was established on the basis of bilateral uveitis and urinalysis results in accordance with a clinical criteria of tubulointerstitial nephritis. With treatment with oral prednisolone (PSL) at 20 mg/day, ocular findings improved, and the dose of PSL was gradually reduced and withdrawn 6 months later. However, 1 month later from the withdrawal, ocular inflammation recurred with the presence of retinal exudates and snowball vitreous opacities in the peripheral retina OU. Fluorescein angiography showed leakages from peripheral retinal vessels and staining corresponding to retinal exudates. Indocyanine green angiography showed hypofluorescent dots scattered over the ocular fundus. Optical coherence tomography revealed the presence of choroidal thickening. Laser speckle flowgraphy color map showed a relatively cooler color. Findings from these multimodal images indicated the presence of subclinical choroiditis; therefore, oral PSL was administered again, and ocular inflammatory findings were improved. CONCLUSIONS: TINU syndrome can exhibit subclinical choroiditis detected with multimodal imaging. Further studies are necessary to determine the frequency of subclinical choroiditis in TINU syndrome.

Alterations in choroidal circulatory dynamics and choroidal thickness before and after treatment in posterior scleritis.
Mizuho Mitamura, Satoru Kase, Yui Yamashita, Kiriko Hirooka, Susumu Ishida
BMC ophthalmology, 23, 1, 382, 382, 2023年09月19日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Posterior scleritis is an inflammatory reaction of the sclera that occurs posterior to the ora serrata. The aim of this study was to present a case of posterior scleritis and to analyze choroidal circulatory and structural changes using laser speckle flowgraphy (LSFG) and optical coherence tomography (OCT), respectively. CASE PRESENTATION: A 64-year-old man presented to our department because of hyperemia of the left eye for one week, diplopia, ocular pain, and distorted vision when looking leftward. At an initial examination, his best-corrected visual acuity was 1.0 Oculi uterque (OU), with mild conjunctival hyperemia oculus dexter (OD) and marked ciliary hyperemia oculus sinister (OS). Color fundus photographs revealed a cluster of choroidal folds extending from the macula to the inferior retinal region OS. Swept-Source OCT showed choroidal thickening OD, and bacillary layer detachment and paracentral middle maculopathy on the paracentral side of the optic nerve papilla, suggesting severe inflammation. Fluorescein angiography showed hyperfluorescence in the optic disc and window defects around the macula OU. Indocyanine green angiography showed mottled choroidal vascular hyperpermeability findings in the late stage. B-mode echography displayed thickening of the posterior wall of the left eye. Orbital magnetic resonance imaging showed the thickened posterior eyeball. The patient was diagnosed with posterior scleritis, and 30 mg of oral prednisolone was then given and tapered off over the next 4 months. The hyperemia and intraocular inflammation resolved after the treatment. The rate of change in macular blood flow assessed by the mean blur rate on LSFG was 20.5% and 20.2% decrease OD and OS, respectively, before and after treatment. The central choroidal thickness showed 8.8% and 37.8% decrease OD and OS, respectively. CONCLUSION: Posterior scleritis complicated with choroiditis was suggested to show different choroidal circulatory dynamics from those in other choroidal inflammations.

Phosphorylation of αB-Crystallin Involves Interleukin-1β-Mediated Intracellular Retention in Retinal Müller Cells: A New Mechanism Underlying Fibrovascular Membrane Formation.
Taku Yamamoto, Satoru Kase, Akihiro Shinkai, Miyuki Murata, Kasumi Kikuchi, Di Wu, Yasushi Kageyama, Masami Shinohara, Tomohiko Sasase, Susumu Ishida
Investigative ophthalmology & visual science, 64, 10, 20, 20, 2023年07月03日, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: Chronic inflammation plays a pivotal role in the pathology of proliferative diabetic retinopathy (PDR), in which biological alterations of retinal glial cells are one of the key elements. The phosphorylation of αB-crystallin/CRYAB modulates its molecular dynamics and chaperone activity, and attenuates αB-crystallin secretion via exosomes. In this study, we investigated the effect of phosphorylated αB-crystallin in retinal Müller cells on diabetic mimicking conditions, including interleukin (IL)-1β stimuli. METHODS: Human retinal Müller cells (MIO-M1) were used to examine gene and protein expressions with real-time quantitative PCR, enzyme linked immunosorbent assay (ELISA), and immunoblot analyses. Cell apoptosis was assessed by Caspase-3/7 assay and TdT-mediated dUTP nick-end labeling staining. Retinal tissues isolated from the Spontaneously Diabetic Torii (SDT) fatty rat, a type 2 diabetic animal model with obesity, and fibrovascular membranes from patients with PDR were examined by double-staining immunofluorescence. RESULTS: CRYAB mRNA was downregulated in MIO-M1 cells with the addition of 10 ng/mL IL-1β; however, intracellular αB-crystallin protein levels were maintained. The αB-crystallin serine 59 (Ser59) residue was phosphorylated with IL-1β application in MIO-M1 cells. Cell apoptosis in MIO-M1 cells was induced by CRYAB knockdown. Immunoreactivity for Ser59-phosphorylated αB-crystallin and glial fibrillary acidic protein was colocalized in glial cells of SDT fatty rats and fibrovascular membranes. CONCLUSIONS: The Ser59 phosphorylation of αB-crystallin was modulated by IL-1β in Müller cells under diabetic mimicking inflammatory conditions, suggesting that αB-crystallin contributes to the pathogenesis of PDR through an anti-apoptotic effect.

Alterations of choroidal circulation and choroidal thickness before and after chemoradiotherapy in a case of metastatic choroidal tumor.
Mizuho Mitamura, Satoru Kase, Kiriko Hirooka, Susumu Ishida
BMC ophthalmology, 23, 1, 270, 270, 2023年06月13日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Metastatic choroidal tumors are hematogenous intraocular metastases of malignant tumors in systemic organs; however, the details of choroidal circulation and morphological changes in the choroid are unknown. The aim of this study is to present a case of metastatic choroidal tumor and examine laser speckle flowgraphy (LSFG)-based choroidal circulation and central choroidal thickness (CCT) before and after chemoradiotherapy. CASE PRESENTATION: A 66-year-old woman with a medical history of breast cancer 16 years ago was referred to our department struggling with blurred vision in her right eye. At the time of initial examination, her best-corrected visual acuity (BCVA) was 0.4 oculus dexter (OD) and 0.9 oculus sinister. Fundus revealed a yellowish-white choroidal elevated lesion measuring 8 papillary diameters with serous retinal detachment (SRD) in the posterior pole. Fluorescein angiography showed diffuse hyperfluorescence and fluorescent leakage due to SRD, and indocyanine green angiography demonstrated no abnormalities in the macula but hypofluorescence in the center of the tumor. Based on these clinical findings, she was diagnosed with metastatic choroidal tumor. After chemoradiotherapy, the metastatic choroidal tumor became scarred, and SRD disappeared. The rate of changes in macular blood flows assessed by mean blur rate on LSFG and CCT of her right eye were 33.8 and 32.8% decrease at 5 months after the initial visit, respectively. BCVA was 0.5 OD 27 months after the initial examination. CONCLUSION: Chemoradiotherapy resulted in regression of the metastatic choroidal tumor and disappearance of SRD, with a decrease in central choroidal blood flow and CCT. The choroidal blood flow on LSFG could reflect an increased oxygen demand by cancer cells invading the choroid and substantial blood supply.

Addendum: Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect.
Mizuho Mitamura, Satoru Kase, Kiriko Hirooka, Susumu Ishida
Oncotarget, 14, 542, 542, 2023年05月26日, ［国際誌］
英語

A case of APMPPE-like panuveitis presenting with extensive outer retinal layer impairment following COVID-19 vaccination.
Yo Ogino, Kenichi Namba, Daiju Iwata, Kayo Suzuki, Kazuomi Mizuuchi, Miki Hiraoka, Nobuyoshi Kitaichi, Susumu Ishida
BMC ophthalmology, 23, 1, 233, 233, 2023年05月24日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Vaccination against the worldwide pandemic coronavirus disease 2019 (COVID-19) is underway; however, some cases of new onset uveitis after vaccination have been reported. We report a case of bilateral acute posterior multifocal placoid pigment epitheliopathy-like (AMPPE-like) panuveitis after COVID-19 vaccination in which the patient's pathological condition was evaluated using multimodal imaging. CASE PRESENTATION: A 31-year-old woman experienced bilateral hyperemia and blurred vision starting 6 days after her second inoculation of the COVID-19 vaccination. At her first visit, her visual acuity was decreased bilaterally, and severe bilateral anterior chamber inflammation and bilateral scattering of cream-white placoid lesions on the fundus were detected. Optical coherence tomography (OCT) showed serous retinal detachment (SRD) and choroidal thickening in both eyes (OU). Fluorescein angiography (FA) revealed hypofluorescence in the early phase and hyperfluorescence in the late phase corresponding to the placoid legions. Indocyanine green angiography (ICGA) showed sharply marginated hypofluorescent dots of various sizes throughout the mid-venous and late phases OU. The patient was diagnosed with APMPPE and was observed without any medications. Three days later, her SRD disappeared spontaneously. However, her anterior chamber inflammation continued, and oral prednisolone (PSL) was given to her. Seven days after the patient's first visit, the hyperfluorescent lesions on FA and hypofluorescent dots on ICGA partially improved; however, the patient's best corrected visual acuity (BCVA) recovered only to 0.7 OD and 0.6 OS, and the impairment of the outer retinal layer was broadly detected as hyperautofluorescent lesions on fundus autofluorescence (FAF) examination and as irregularity in or disappearance of the ellipsoid and interdigitation zones on OCT, which were quite atypical for the findings of APMPPE. Steroid pulse therapy was performed. Five days later, the hyperfluorescence on FAF had disappeared, and the outer retinal layer improved on OCT. Moreover, the patient's BCVA recovered to 1.0 OU. Twelve months after the end of treatment, the patient did not show any recurrences. CONCLUSIONS: We observed a case of APMPPE-like panuveitis after COVID-19 vaccination featuring some atypical findings for APMPPE. COVID-19 vaccination may induce not only known uveitis but also atypical uveitis, and appropriate treatment is required for each case.

Effects of Mirogabalin on Hyperalgesia and Chronic Ocular Pain in Tear-Deficient Dry-Eye Rats.
Kasumi Kikuchi, Yoshiaki Tagawa, Miyuki Murata, Susumu Ishida
Investigative ophthalmology & visual science, 64, 5, 27, 27, 2023年05月01日, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: Patients with dry eye disease (DED) sometimes complain of ocular pain. DED-related ocular pain has many similarities with neuropathic pain. Mirogabalin, a novel ligand for the α2δ subunit of voltage-gated calcium channels, is approved for treating neuropathic pain in Japan. This study aimed to investigate the effect of mirogabalin on hyperalgesia and chronic ocular pain in a rat DED model. METHODS: DED was induced in female Sprague Dawley rats by unilaterally excising the external lacrimal gland (ELG) and Harderian gland (HG). After 4 weeks of ELG and HG removal, tear production (pH threads) and corneal epithelial damage (fluorescein staining) were evaluated. Corneal hyperalgesia and chronic pain were analyzed, respectively, by measuring capsaicin-induced eye-wiping behavior and c-Fos expression in the trigeminal nucleus. Mirogabalin (10 or 3 mg/kg) was evaluated for effects on DED-induced hyperalgesia and chronic ocular pain. RESULTS: Tear production was significantly lower in DED-induced eyes than in control eyes. Corneal damage was significantly higher in DED eyes than in control eyes. Hyperalgesia and chronic ocular pain were detected 4 weeks after ELG and HG removal. Five days of mirogabalin administration significantly suppressed capsaicin-induced eye-wiping behavior, which indicated the suppression of ocular hyperalgesia. Administration of 10 mg/kg mirogabalin significantly reduced c-Fos expression in the trigeminal nucleus, which indicated the amelioration of chronic ocular pain. CONCLUSIONS: Mirogabalin suppressed DED-induced hyperalgesia and chronic ocular pain in a rat DED model. Our findings suggested that mirogabalin might effectively alleviate chronic ocular pain in patients with DED.

A case of choroidal melanocytosis observed by multimodal imaging with laser speckle flowgraphy.
Mizuho Mitamura, Satoru Kase, Kiriko Hirooka, Susumu Ishida
BMC ophthalmology, 23, 1, 180, 180, 2023年04月26日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Choroidal melanocytosis is characterized by congenital diffuse melanin pigmentation with extensive parenchymal infiltration of spindle cells in the choroid; however, little is known about the choroidal circulation and morphological changes. We herein report a case of choroidal melanocytosis observed by multimodal imaging with laser speckle flowgraphy (LSFG). CASE PRESENTATION: A 56-year-old woman was referred to our hospital because of serous retinal detachment (SRD) in her left eye. At the initial examination, her best-corrected visual acuity (BCVA) was 1.5 oculus dexter (OD) and 0.8 oculus sinister (OS). An irregular, flat, brownish lesion was noted around the macula OS. Optical coherence tomography showed a choroidal structure with marked hyporeflectivity and SRD where the retinal thickness was preserved. Indocyanine green angiography demonstrated fluorescence blockade throughout. Fundus autofluorescence revealed enlarged macular hypofluorescence, suggesting chronic retinal pigment epithelium damage associated with prolonged SRD. B-mode echography showed no choroidal elevation. Based on the clinical findings, the left eye was diagnosed with choroidal melanocytosis. Four years and 10 months after the initial visit, her BCVA was 0.5 and SRD remained. During the entire period of observation, the mean blur rate (MBR) (mean ± standard deviation) of choroidal blood flow velocity on LSFG was 10.15 ± 0.72 arbitrary units (AU) OD and 1.31 ± 0.06 AU OS. CONCLUSION: Choroidal melanocytosis presented with chronic minor circulatory disturbances due to melanocyte proliferation in the choroid, but the markedly low MBR values by LSFG were dissociated from her retinal thickness and visual function. The proliferation of melanocytes may be a cause of overestimating the cold-color signal of LSFG due to their pigmentation.

The Steroid-Sparing Effect of Adalimumab in the Treatment for the Recurrent Phase of Vogt-Koyanagi-Harada Disease.
Mayuko Shinagawa, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Keitaro Hase, Kayo Suzuki, Kiriko Hirooka, Nobuyoshi Kitaichi, Miki Hiraoka, Susumu Ishida
Ocular immunology and inflammation, 31, 3, 501, 505, 2023年04月, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: To reveal the steroid-sparing effect of adalimumab (ADA) in the treatment for the chronic recurrent phase of Vogt-Koyanagi-Harada (VKH) disease. CASES AND METHODS: Thirty-six eyes from 18 cases of the recurrent phase of VKH disease treated with ADA over 12 months were examined retrospectively. Before the introduction of ADA, 4 cases received prednisolone (PSL) monotherapy and other 14 cases received PSL and cyclosporine A (CYA) combination therapy. RESULTS: In cases treated with PSL and CYA, CYA was discontinued when ADA was introduced. The minimum dose of PSL to control intraocular inflammation (min dose of PSL) could be reduced in all cases after the introduction of ADA (from 16.9 ± 7.9 mg to 6.3 ± 3.1 mg). No serious adverse events were observed in the observational periods. CONCLUSION: By comparing the min dose of PSL before and after the introduction of ADA, the steroid-sparing effect of ADA was confirmed.

Choroidal Circulatory and Vascular Morphological Changes in Acute Macular Neuroretinopathy After Infection With Severe Acute Respiratory Syndrome Coronavirus 2: A Case Report With Literature Review.
Mizuho Mitamura, Satoru Kase, Kiriko Hirooka, Hiroaki Endo, Yuki Ito, Susumu Ishida
In vivo (Athens, Greece), 37, 6, 2869, 2876, 2023年, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND/AIM: The aim of this study was to analyze choroidal circulatory and structural changes using laser speckle flowgraphy (LSFG) and optical coherence tomography (OCT) in acute macular neuroretinopathy (AMN) after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), respectively. CASE REPORT: A 24-year-old woman complained of distorted vision after SARS-CoV-2 infection oculi uterque (OU) and referred to our hospital because of ellipsoid zones (EZ) disruption on OCT. Her best-corrected visual acuity (BCVA) was 1.2 OU. Color fundus photographs revealed dark red lesions in the macula, and scanning laser ophthalmoscopy infrared images showed hypointensity consistent with dark red lesions OU. We diagnosed the patient with AMN after SARS-CoV-2 infection, and posterior sub-Tenon injections of triamcinolone acetonide were performed OU. Five months after the initial visit, her BCVA was 1.2 OU, and EZ disruption improved. The rate of change in macular blood flow assessed by the mean blur rate on LSFG was 20.4% and 29.6% increase oculus dexter (OD) and oculus sinister (OS) 5 months after the initial visit, respectively. The central choroidal thickness showed 13.5% increase OD and 16.1% increase OS. The binarization technique demonstrated that the ratio of luminal areas in choroidal area increased by 12.6% OD and 14.2% OS, and stromal areas increased by 7.3% OD and 16.9% OS. CONCLUSION: Before and after treatment for AMN, the luminal component may have increased with improvement of acute choroidal circulatory disturbance caused by SARS-CoV-2, and increased stromal components may be due to chronic inflammation and tissue remodeling of the stroma.

Peripapillary circulatory dysfunction precedes structural loss in treatment-naive diabetic retinopathy.
Mizuho Mitamura, Hiroaki Endo, Satoru Kase, Zhenyu Dong, Mitsuo Takahashi, Satoshi Katsuta, Manabu Kase, Susumu Ishida
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 261, 1, 85, 95, 2023年01月, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: The aim of this study was to compare the timing of peripapillary vascular damage between functional and structural parameters and examine their involvement with neurovascular coupling at different stages of diabetic retinopathy (DR). METHODS: One hundred ninety eyes of 143 patients with type 2 diabetes mellitus (DM) and 88 healthy control eyes were enrolled. Eyes of DM patients were divided into 3 stages with no diabetic retinopathy (NDR), non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR). NPDR and PDR eyes were treatment-naive. OCT angiography was used to calculate radial peripapillary capillary (RPC)-flux index (FI) and RPC-perfusion density (PD). Spectral domain OCT was used to measure retinal nerve fiber layer (RNFL) thickness within the corresponding RPC areas. RESULTS: RPC-FI significantly decreased in NDR eyes compared to control eyes and thereafter remained unchanged among DM (NDR, NPDR, and PDR) eyes. In contrast, RPC-PD stayed unaltered between control and NDR eyes and significantly decreased in NPDR followed by PDR eyes at similar levels. From control to NPDR eyes, RNFL thickness showed positive correlations with both RPC-FI and RPC-PD, indicative of functional and structural neurovascular coupling. These vascular parameters were also correlated with each other in control and NPDR eyes but not NDR eyes, consistent with the difference in the timing of vascular damage between functional and structural parameters. CONCLUSIONS: Circulatory dysfunction preceded structural loss while maintaining peripapillary neurovascular coupling during progression of DR stages. RPC-FI would likely be more sensitive than RPC-PD in detecting early vascular damage in DR.

Two-year clinical outcomes of triple therapy with photodynamic therapy, anti-vascular endothelial growth factor agent, and triamcinolone acetonide for neovascular age-related macular degeneration.
Ryo Ando, Kiriko Hirooka, Michiyuki Saito, Satoru Kase, Kousuke Noda, Susumu Ishida
Japanese journal of ophthalmology, 67, 1, 50, 58, 2023年01月, ［国内誌］
英語, 研究論文（学術雑誌）, PURPOSE: To analyze the 2-year treatment outcomes of triple therapy with standard-fluence photodynamic therapy (PDT), intravitreal injection of ranibizumab (IVR)/aflibercept (IVA), and sub-tenon injection of triamcinolone acetonide (STTA) for neovascular age-related macular degeneration (nAMD) in Japanese patients. STUDY DESIGN: A retrospective, clinical case-series study. METHODS: Forty-four eyes of 44 patients with treatment-naïve nAMD followed for more than 24 months were evaluated. Initial treatment was given with triple therapy and retreatment with IVR/IVA as a pro re nata regimen. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), the number of treatments, and intraocular pressure elevation were analyzed. RESULTS: The mean age was 73.3 ± 10.0 years. The mean BCVA significantly improved from 0.61 ± 0.30 at baseline to 0.50 ± 0.46 at 24 months (p = 0.034). CRT significantly improved from 373 ± 162 μm at baseline to 200 ± 107 μm at 24 months (p < 0.001). The number of treatments given during the 2-year treatment period was 2.7 ± 1.8. No retreatments were necessary in 18 of 44 eyes (40.9%), with no significant difference between IVR (46.4%) or IVA (31.3%) used during the 2-year follow-up of triple therapy (p = 0.51). Four eyes (9.1%) temporarily required glaucoma eye drop treatments. CONCLUSION: In nAMD patients, induction treatment with triple therapy resulted in approximately 40% of the patients requiring no retreatment for 2 years. The type of anti-VEGF agents used made no difference in the results.

A Case of Intraocular Metastasis of Lung Cancer Diagnosed Using Cell Block Preparation of the Vitreous Humor.
Kohei Matsumoto, Satoru Kase, Kenichi Namba, Daiju Iwata, Yoshihiro Matsuno, Susumu Ishida
Cancer diagnosis & prognosis, 3, 1, 130, 134, 2023年, ［国際誌］
英語, BACKGROUND/AIM: Masquerade syndrome is characterized by uveitis-like manifestations caused by tumor cell infiltration into the ocular tissues. The aim of the study was to report a lung cancer patient with persistent unilateral vitreous opacity, who was eventually diagnosed with masquerade syndrome using cell block preparation. CASE REPORT: An 82-year-old female complained of blurred vision in her left eye (OS). Because of pulmonary adenocarcinoma, she had previously received anticancer drug treatment at another Hospital and achieved partial remission. Ophthalmic examinations revealed anterior chamber inflammation and vitreous opacity OS. Corticosteroid eye drops were administered, but the inflammation did not improve, and was referred to the Hokkaido University Hospital. The left best-corrected visual acuity was 0.1 with normal intraocular pressure. Anterior chamber inflammation was 2+ cells, and vitreous haze was 4+ OS. B-mode ultrasonography showed diffuse heterogeneous high echoic changes in the vitreous cavity. She underwent vitrectomy, and cell block preparation of the vitreous infusion fluids was performed. Cytopathology revealed adenocarcinoma cells with a high nuclear/cytoplasmic ratio and glandular formation. The immunocytochemical study showed that tumor cells were positive for thyroid transcription factor-1 (TTF-1), napsin A, and CK7, therefore diagnosis of masquerade syndrome due to intraocular metastasis of pulmonary adenocarcinoma was reached. Chemoradiotherapy was administered, and the eye got phthisis bulbi after irradiation 2 years after diagnosis. CONCLUSION: Cell block preparation using vitreous humor may be useful in the diagnosis and management of intraocular metastasis of pulmonary adenocarcinoma in patients with prolonged vitreous opacity.

Involvement of Angiopoietin 2 and vascular endothelial growth factor in uveitis.
Kayo Suzuki, Daiju Iwata, Kenichi Namba, Keitaro Hase, Miki Hiraoka, Miyuki Murata, Nobuyoshi Kitaichi, Richard Foxton, Susumu Ishida
PloS one, 18, 11, e0294745, 2023年, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: Angiopoietin (Ang) 2 is released from vascular endothelial cells by the stimulation of vascular endothelial growth factor (VEGF)A. Ang2 increases the expression of leukocyte adhesion molecules on endothelial cells via nuclear factor κB. The aim of this study was to evaluate the effects of Ang2 and VEGFA on ocular autoimmune inflammation. METHODS: We measured the concentrations of Ang2 and VEGFA in vitreous samples among patients with uveitis. Vitreous samples were collected from 16 patients with idiopathic uveitis (uveitis group) and 16 patients with non-inflammatory eye disease (control group). Experimental autoimmune uveoretinitis (EAU) was induced in B10.BR mice with a human interphotoreceptor retinoid-binding protein-derived peptide. The retinochoroidal tissues of the EAU mice were removed, and the mRNA levels of Ang2 and VEGFA were examined. EAU mice treated with anti-Ang2, anti-VEGFA, a combination of anti-Ang2 and anti-VEGFA, anti-Ang2/VEGFA bispecific, or IgG control antibodies were clinically and histopathologically evaluated. RESULTS: The protein levels of Ang2 and VEGFA were significantly higher in the vitreous samples of patients with uveitis than in controls (P<0.05). The retinochoroidal mRNA levels of Ang2 and VEGFA were significantly upregulated in EAU mice compared to controls (n = 6, P<0.05). Although there was no significant difference, treatment with anti-VEGFA antibody reduced the clinical and histopathological scores. However, treatment with anti-Ang2 antibody reduced the clinical and histopathological scores (n = 18-20, P<0.05). Furthermore, these scores were further decreased when treated by inhibiting both Ang2 and VEGFA. CONCLUSIONS: Based on these results, VEGFA and Ang2 were shown to be upregulated locally in the eye of both uveitis patients and models of uveitis. Dual inhibition of Ang2 and VEGFA is suggested to be a new therapeutic strategy for uveitis.

Insidious progression of atrophic lesions in a case of posterior polar annular choroidal dystrophy.
Risako Sone, Kousuke Noda, Kiriko Hirooka, Michiyuki Saito, Susumu Ishida
American journal of ophthalmology case reports, 28, 101708, 101708, 2022年12月, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: To describe the clinical course of a case of posterior polar annular choroidal dystrophy (PPACD) followed for 5 years. OBSERVATIONS: A 64-year-old female patient presented with blurred vision. The patient had no subjective symptoms of night blindness or visual field defects. At the initial visit, the patient's visual acuity was 20/20 in both eyes. Bilateral fundus examination revealed atrophic lesions surrounding the optic nerve head, extending to the temporal arcades in an annular pattern. Fundus autofluorescence (FAF) revealed hypoautofluorescent areas corresponding to atrophic lesions, and Goldmann perimetry revealed ring scotomas consistent with lesions in the fundus. Swept-source optical coherence tomography revealed retinal pigment epithelium atrophy, loss of the choriocapillaris, and dilation of the choroidal medium and large vessels in the atrophic area. Full-field electroretinography revealed a mild reduction in the combined rod-cone response. Laser speckle flowgraphy revealed a cold color in the posterior pole of both eyes. Based on clinical and imaging findings, the patient was diagnosed with PPACD and followed up for 5 years. At the 5-year visit, visual acuity remained unchanged, while FAF and Goldmann perimetry revealed a slight enlargement of the atrophic lesions and scotoma in both eyes, respectively. CONCLUSIONS AND IMPORTANCE: In the present case, atrophic lesions insidiously progressed and resulted in a slight enlargement of the hypoautofluorescent area and scotoma over a 5-year follow-up period, indicating that PPACD is a gradually progressive dystrophy.

Fundus autofluorescence imaging in acute posterior multifocal placoid pigment epitheliopathy.
Koichi Yokoi, Kenichi Namba, Daiju Iwata, Kazuomi Mizuuchi, Keitaro Hase, Kayo Suzuki, Ryo Ando, Kiriko Hirooka, Nobuko Sekine, Nobuyoshi Kitaichi, Miki Hiraoka, Susumu Ishida
American journal of ophthalmology case reports, 28, 101732, 101732, 2022年12月, ［国際誌］
英語, PURPOSE: Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a disease characterized by multiple yellowish-white placoid lesions. Although most lesions resolve spontaneously, some turn into scars and lead to permanent visual dysfunction. In this report, we found suggestive findings in fundus autofluorescence (FAF) that may be useful for distinguishing severe lesions requiring treatment in APMPPE. OBSERVATION: Case 1: A 29-year-old woman was referred to our hospital with multiple yellowish-white placoid lesions on the fundi of both eyes (OU). FAF showed hyperautofluorescence in some of these placoid lesions. Based on the findings of fluorescein angiography, a diagnosis of APMPPE was established, and oral prednisolone (PSL) was initiated, given that some lesions were located in the macula. One week later, exacerbation occurred with the newly developed hyperautofluorescent lesions. Some lesions in the right eye (OD) that were hyperautofluorescent at the first visit became hypoautofluorescent. Afterward, although all hypoautofluorescent lesions persisted, most of the hyperautofluorescent lesions disappeared, so oral PSL could be stopped. Two months later, however, the recurrence occurred along with multiple new placoid lesions. Some lesions located at the macula were hyperautofluorescent on FAF OU, indicating the possibility of becoming scar lesions with hypoautofluorescence. Accordingly, oral PSL was given again. CASE 2: A 47-year-old woman noticed decreased vision OD, and she was referred to us. Multiple yellowish-white placoid lesions were seen in the fundi OU. FAF showed hyperautofluorescence both with and without corresponding hypoautofluorescence in the placoid lesions OU. A diagnosis of APMPPE was established, and oral PSL was initiated. Four months later, some lesions that were hyperautofluorescent at the first visit had turned isoautofluorescent, and some lesions OU became hypoautofluorescent. However, all hypoautofluorescent lesions remained hypoautofluorescent OU. Only some hyperautofluorescent lesions recovered to isoautofluorescence without scars. CONCLUSIONS AND IMPORTANCE: In APMPPE, lesions showing hyperautofluorescence on FAF may change into hypoautofluorescence indicating scar formation. Therefore, the presence of hyperautofluorescent lesions in the macula may be a good indicator of the need for intensive corticosteroid treatments to avoid leaving hypoautofluorescent scars that are related to irreversible visual dysfunction.

Clinical significance of serum and vitreous soluble interleukin-2 receptor in patients with intraocular lymphoma.
Kayo Suzuki, Kenichi Namba, Satoru Kase, Yo Ogino, Keitaro Hase, Daiju Iwata, Kazuomi Mizuuchi, Miki Hiraoka, Nobuyoshi Kitaichi, Susumu Ishida
BMC ophthalmology, 22, 1, 428, 428, 2022年11月10日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Intraocular lymphoma (IOL) is a masquerade syndrome that mimics uveitis, making diagnosis difficult. The serum soluble interleukin-2 receptor (sIL-2R), which is cleaved by matrix metalloproteinase (MMP) -2 and MMP-9, has been recognized as a tumor-related biomarker of malignant lymphomas. The aim of this study was to review the reliability of serum and vitreous sIL-2R for distinguishing IOL from uveitis. METHODS: Patients who underwent diagnostic vitrectomy for marked vitreous haze at Hokkaido University Hospital between April 2014 and June 2019 were enrolled. The patients were divided into an IOL group and a uveitis group, according to the pathology of their vitreous samples. The IOL group was further divided at the time of vitrectomy into patients who already had extraocular involvement (IOL with extraocular involvement group) and patients with no evidence of having extraocular involvement (IOL without extraocular involvement group). Serum sIL-2R, and intravitreal sIL-2R, MMP-2, and MMP-9 levels were assessed. RESULTS: Twenty-five eyes of 25 patients, and 15 eyes of 15 patients were included in the IOL group and uveitis group, respectively. The serum sIL-2R levels were significantly lower in the IOL group than in the uveitis group (P < 0.05), and 20.0% and 66.7% in the IOL and the uveitis group showed high sIL-2R value above the normal range. Vitreous sIL-2R tended to be higher in the IOL group than in the uveitis group (P = 0.80). Serum sIL-2R was significantly lower in the IOL without extraocular involvement group than in the IOL with extraocular involvement group (P < 0.05); 5.9% in the IOL without extraocular involvement group and 50.0% in the IOL with extraocular involvement group showed high sIL-2R value above the normal range. Vitreous sIL-2R, MMP-2, and MMP-9 tended to be higher in the IOL with extraocular involvement group than in the IOL without extraocular involvement group (P = 0.30, < 0.05, 0.16). CONCLUSIONS: Serum sIL-2R is often within the normal range in IOL patients. Even if it is within the normal range, the possibility of IOL should be considered. Serum sIL-2R is not a reliable biomarker for IOL, whereas vitreous sIL-2R may be useful for the diagnosis of IOL.

Relationship between Brachial-Ankle Pulse Wave Velocity and Fundus Arteriolar Area Calculated Using a Deep-Learning Algorithm.
Kanae Fukutsu, Michiyuki Saito, Kousuke Noda, Miyuki Murata, Satoru Kase, Ryosuke Shiba, Naoki Isogai, Yoshikazu Asano, Nagisa Hanawa, Mitsuru Dohke, Manabu Kase, Susumu Ishida
Current eye research, 47, 11, 1534, 1537, 2022年11月, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: Retinal vessels reflect alterations related to hypertension and arteriosclerosis in the physical status. Previously, we had reported a deep-learning algorithm for automatically detecting retinal vessels and measuring the total retinal vascular area in fundus photographs (VAFP). Herein, we investigated the relationship between VAFP and brachial-ankle pulse wave velocity (baPWV), which is the gold standard for arterial stiffness assessment in clinical practice. METHODS: Retinal photographs (n = 696) obtained from 372 individuals who visited the Keijinkai Maruyama Clinic for regular health checkups were used to analyze VAFP. Additionally, the baPWV was measured for each patient. Automatic retinal-vessel segmentation was performed using our deep-learning algorithm, and the total arteriolar area (AA) and total venular area (VA) were measured. Correlations between baPWV and several parameters, including AA and VA, were assessed. RESULTS: The baPWV was negatively correlated with AA (R = -0.40, n = 696, P < 2.2e-16) and VA (R = -0.36, n = 696, P < 2.2e-16). Independent variables (AA, sex, age, and systolic blood pressure) selected using the stepwise method showed a significant correlation with baPWV. The estimated baPWV, calculated using a regression equation with variables including AA, showed a better correlation with the measured baPWV (R = 0.70, n = 696, P < 2.2e-16) than the estimated value without AA (R = 0.68, n = 696, P < 2.2e-16). CONCLUSIONS: AA and VA were significantly correlated with baPWV. Moreover, baPWV estimated using AA correlated well with the actual baPWV. VAFP may serve as an alternative biomarker for evaluating systemic arterial stiffness.

Surgical outcomes of partial ciliary body direct suturing under the scleral flap for traumatic cyclodialysis cleft: A five-case series.
Riki Kijima, Yasuhiro Shinmei, Akihiro Shinkai, Rina Kanaya, Shinki Chin, Susumu Ishida
European journal of ophthalmology, 32, 6, 3712, 3719, 2022年11月, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Cyclodialysis cleft is an uncommon finding due to blunt ocular trauma. A larger and more chronic cyclodialysis requires surgical repair. The aim of this study was to introduce a minimally invasive suturing technique for the lens-sparing repair of traumatic cyclodialysis cleft and evaluate outcomes. METHODS: This study was a retrospective case series. The medical and surgical records of five patients with traumatic cyclodialysis cleft who underwent this surgery were reviewed. The surgeon (Y.S.) dissected a fornix-based conjunctival flap and created a 90° circumferential and limbal-based scleral flap. Several small incisions parallel to the limbus were made within the scleral bed 1.5 and 3 mm posterior to the limbus. After suprachoroidal fluid drainage, tiny bumps in the ciliary body were exposed from the incisions and sewn directly onto the scleral bed with 10-0 nylon sutures. RESULTS: The mean age of the patients was 37.8 ± 1.3 years. The mean duration from injury to surgery was 14.8 ± 16.7 months. Mean best-corrected visual acuity (BCVA) was 0.56 ± 0.70 and intraocular pressure (IOP) was 5.2 ± 1.9 mmHg. In all patients, IOP normalized and BCVA then returned to baseline following this procedure. Mean postoperative BCVA was 1.17 ± 0.86 and IOP was 17.8 ± 1.3 mmHg. Mean IOP and BCVA recovery times were 82.0 ± 139.6 and 294.3 ± 284.3 days, respectively. CONCLUSIONS: Partial ciliary body direct suturing under the scleral flap is a less invasive surgical option without lensectomy and considered safe and effective as a primary surgical repair for traumatic cyclodialysis cleft.

Reduction of Intraocular Pressure and Aqueous Outflow Resistance after Modified 360-degree Suture Trabeculotomy.
Kayo Suzuki, Yasuhiro Shinmei, Kiriko Hirooka, Rina Kanaya, Akihiro Shinkai, Riki Kijima, Shinki Chin, Yoichi M Ito, Susumu Ishida
Journal of glaucoma, 2022年10月12日, ［国際誌］
英語, 研究論文（学術雑誌）, PRCIS: Decreasing aqueous outflow resistance at trabecular meshwork is the main mechanism of modified 360-degree suture trabeculotomy, and the preoperative C-value, which shows aqueous outflow resistance, is likely to be useful for predicting IOP reduction. PURPOSE: To clarify the mechanism of intraocular pressure (IOP) reduction and the preoperative prognostic predictor of modified 360-degree suture trabeculotomy (ST). PATIENTS AND METHODS: Forty-three eyes of 32 patients with glaucoma who underwent ST at Hokkaido University Hospital between April 2017 and February 2020 were enrolled. The records of postoperative IOP and coefficient of aqueous outflow (C-value) after ST were reviewed from clinical charts retrospectively. Preoperative IOP and C-values were also reviewed and considered as the baseline. RESULTS: Although the differences were not significant, IOP decreased to 15.4±3.3 mmHg at 3 months (P=0.10) and 16.1±3.8 mmHg at 6 months (P=0.21). In addition, there were significant decreases in anti-glaucoma medication scores at both 3 and 6 months after surgery (P<0.01). The C-value increased significantly to 0.24±0.11 µl/min/mmHg at 3 months (P<0.01) and increased significantly to 0.27±0.14 µl/min/mmHg at 6 months (P<0.01). The rates of change in IOP were negatively correlated with that in the C-value at 3 months (r=-0.49 and P<0.01) and 6 months (r=-0.46 and P<0.01). The success rate (IOP<21 mmHg, IOP reduction>20%) was greater in the low baseline C-value group (≤0.17) than high baseline C-value group (>0.17) (P<0.05), and the baseline IOP and C-values were statistically significant in association with the success (P<0.05) at 6 months. CONCLUSIONS: Increased conventional outflow by elimination of the aqueous outflow resistance at the trabecular meshwork is the main mechanism of IOP reduction after ST. Preoperative examination of tonographic outflow facility may be useful for predicting the IOP reduction and outcome of ST.

Diffuse large b-cell lymphoma of the ocular adnexa with flow cytometry analysis and review of the literature.
Mizuho Mitamura, Satoru Kase, Yasuo Suzuki, Takatoshi Sakaguchi, Yuka Suimon, Toshiya Sinohara, A I Shimizu, Yoshihiro Matsuno, Hajime Sakai, Manabu Kase, Susumu Ishida
European journal of ophthalmology, 11206721221127053, 11206721221127053, 2022年09月16日, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: The aim of this study was to evaluate the clinicopathological features and flow cytometry (FCM) of tumor tissues in ocular adnexal diffuse large B-cell lymphoma (DLBCL). METHODS: This retrospective, multicenter case study was designed to evaluate the clinical and immunohistochemical features of tumors. DLBCL was diagnosed based on histopathology, immunoglobulin (Ig) heavy chain gene rearrangement, and FCM in all surgically removed periocular tumor tissues. This study involved assessing percentages (%) of B-cell/T-cell markers, a natural killer cell marker, and cell-surface Ig kappa/lambda (κ/λ) expression measured by FCM analysis in tumor tissues. RESULTS: Eleven DLBCL patients (4 men and 7 women) with 11 tumors were enrolled in this study. The median age at the time of initial presentation was 73 years. The tumor cells were immunohistochemically positive for cluster of differentiation (CD) 20, while CD5 was negative in all 8 cases tested. At the time of ophthalmic diagnosis, two cases already showed systemic dissemination of DLBCL throughout the body. FCM of tumor tissues detected a high percentage of B-cell markers including CD19 and CD20 in all 11 tumors. One case with high CD10 levels in FCM was histologic transformation from follicular lymphoma. One case with a relatively low CD20 population involved a history of systemic treatments including intravenous rituximab. CONCLUSION: Although caution should be exercised when interpreting the data, FCM is useful for not only supportive diagnosis complementary to immunohistochemistry, but also facilitates a better understanding of immunopathology including histologic transformation of follicular lymphoma to DLBCL in the ocular adnexa.

Subretinal fluid accumulation in a patient with polycythemia vera after receiving a prostaglandin I2 analogue treatment.
Tomoko Noda, Kousuke Noda, Kiriko Hirooka, Satoru Kase, Susumu Ishida
American journal of ophthalmology case reports, 27, 101568, 101568, 2022年09月, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: To report a case of polycythemia vera (PV) with subretinal fluid accumulation after the administration of prostaglandin I2 (PGI2) analogue. OBSERVATIONS: A 57-year-old woman diagnosed as having PV was referred to our department for the evaluation of severe metamorphopsia in the left eye, which gradually progressed after the initiation of oral administration of PGI2 mimetics. At the first visit, the patient's best-corrected visual acuities (BCVAs) were 20/20 OD and 20/30 OS. Fundus examination and optical coherence tomography revealed the presence of subretinal fluid (SRF) in the left eye and multiple serous pigment epithelial detachments (PEDs) in both eyes. Fluorescein angiography revealed central serous chorioretinopathy (CSC)-like lesions, consisting of dye pooling corresponding to the PEDs in both eyes and dye leakage in the left eye. Indocyanine green angiography and laser speckle flowgraphy revealed dilated choroidal veins and reduced choroidal blood flow, respectively. The central choroidal thickness (CCT) measured at the first visit showed a relatively thickened choroid in the left eye. Laboratory data showed mild pancytosis. The patient was diagnosed as having CSC associated with a background of PV, presumably triggered by the PGI2 analogue. One month after cessation of drug administration, the patient's BCVA improved, the CCT slightly decreased, and serous retinal detachment and PED disappeared in the left eye. CONCLUSIONS AND IMPORTANCE: Our case of PV presenting with CSC-like lesions after PGI2 analogue administration indicates the possible risk of SRF accumulation by PGI2 analogues in patients with PV.

Clinical features of ocular sarcoidosis: severe, refractory, and prolonged inflammation.
Kayo Suzuki, Mami Ishihara, Kenichi Namba, Shigeaki Ohno, Hiroshi Goto, Hiroshi Takase, Shigeru Kawano, Etsuko Shibuya, Keitaro Hase, Daiju Iwata, Kazuomi Mizuuchi, Nobuyoshi Kitaichi, Nobuhisa Mizuki, Susumu Ishida
Japanese journal of ophthalmology, 66, 5, 447, 454, 2022年09月, ［国内誌］
英語, 研究論文（学術雑誌）, PURPOSE: To clarify the proportion of ocular sarcoidosis with severe, refractory, and prolonged inflammation and their association with ocular complications and visual prognosis. STUDY DESIGN: Multicenter, retrospective, longitudinal cohort study. METHODS: Three hundred and twenty-three eyes of 164 patients (45 men; 119 women) with ocular sarcoidosis who visited Hokkaido University Hospital and Yokohama City University Hospital from 2010 to 2015. We newly defined severe, refractory, and prolonged inflammation in ocular sarcoidosis, and investigated their proportions, ocular complications and final visual acuity from medical records of our sarcoidosis patients. RESULTS: The eyes with severe inflammation numbered 72/323 (22.3%), with refractory inflammation, 80/323 (24.8%), and with prolonged inflammation, 91/323 (28.2%). The number of eyes having neither severe, refractory, nor prolonged inflammation (defined as none) was 114/323 (35.3%). The numbers of eyes that reached irreversible visual dysfunction were 6/72 (8.3%) of those with severe inflammation, 10/80 (12.5%) with refractory inflammation, 12/91 (13.2%) with prolonged inflammation, and 4/114 (6.2%) with none. As complications, cataract (62.2%), glaucoma (28.5%), epiretinal membrane (24.1%), cystoid macular edema (22.6%), vitreous hemorrhage (2.8%), choroidal atrophy (2.5%), macular degeneration (1.2%), macular hole (0.9%) and retinal detachment (0.3%) were identified. Among them, secondary glaucoma (16 eyes) and macular degeneration (4 eyes) were major complications related to irreversible visual dysfunction. CONCLUSIONS: Although most of the patients with ocular sarcoidosis had a relatively good visual prognosis, some developed severe, refractory, and/or prolonged inflammation related to the development of ocular complications, that resulted in poor visual prognosis.

Placental growth factor stabilizes VEGF receptor-2 protein in retinal pigment epithelial cells by downregulating glycogen synthase kinase 3 activity.
Miyuki Murata, Kousuke Noda, Satoru Kase, Keitaro Hase, Di Wu, Ryo Ando, Susumu Ishida
The Journal of biological chemistry, 298, 9, 102378, 102378, 2022年09月, ［国際誌］
英語, 研究論文（学術雑誌）, Placental growth factor (PlGF) belongs to the vascular endothelial growth factor (VEGF) family of proteins that participate in angiogenesis and vasculogenesis. Anti-VEGF therapy has become the standard treatment for ocular angiogenic disorders in ophthalmological practice. However, there is emerging evidence that anti-VEGF treatment may increase the risk of atrophy of the retinal pigment epithelium (RPE), which is important for the homeostasis of retinal tissue. Whereas the cytoprotective role of VEGF family molecules, particularly that of VEGF A (VEGFA) through its receptor VEGF receptor-2 (VEGFR-2), has been recognized, the physiological role of PlGF in the retina is still unknown. In this study, we explored the role of PlGF in the RPE using PlGF-knockdown RPE cells generated by retrovirus-based PlGF-shRNA transduction. We show that VEGFA reduced apoptosis induced by serum starvation in RPE cells, whereas the antiapoptotic effect of VEGFA was abrogated by VEGFR-2 knockdown. Furthermore, PlGF knockdown increased serum starvation-induced cell apoptosis and unexpectedly reduced the protein level of VEGFR-2 in the RPE. The antiapoptotic effect of VEGFA was also diminished in PlGF-knockdown RPE cells. In addition, we found that glycogen synthase kinase 3 activity was involved in proteasomal degradation of VEGFR-2 in RPE cells and inactivated by PlGF via AKT phosphorylation. Overall, the present data demonstrate that PlGF is crucial for RPE cell viability and that PlGF supports VEGFA/VEGFR-2 signaling by stabilizing the VEGFR-2 protein levels through glycogen synthase kinase 3 inactivation.

Long-term Outcomes of Modified 360-Degree Suture Trabeculotomy for Uveitic Glaucoma Compared With Primary Open Angle Glaucoma.
Riki Kijima, Yasuhiro Shinmei, Shinki Chin, Rina Kanaya, Akihiro Shinkai, Takeshi Ohguchi, Kenichi Namba, Susumu Ishida
Journal of glaucoma, 31, 8, 682, 688, 2022年08月01日, ［国際誌］
英語, 研究論文（学術雑誌）, PRCIS: A Kaplan-Meier survival curve analysis showed no significant differences in success rates between uveitic glaucoma (UG) and primary open angle glaucoma (POAG) 120 months after modified 360-degree suture trabeculotomy, which was effective for both groups in the long term. PURPOSE: The aim of this study was to examine the outcomes of modified 360-degree suture trabeculotomy in patients with UG as compared with those with POAG. PATIENTS AND METHODS: This was a retrospective, nonrandomized, and comparative case series study. Modified 360-degree trabeculotomy using a 5-0 nylon suture (S-LOT) was performed on 51 eyes of 51 patients (54.4±13.4 y) with UG between October 2005 and January 2012 at Hokkaido University Hospital. Age-matched patients with POAG who underwent S-LOT during the same period were enrolled as controls. Written informed consent was obtained from all patients enrolled in the present study. Surgical success was defined as an intraocular pressure (IOP) <18 mm Hg with similar or lower doses of antiglaucoma medications. Kaplan-Meier survival curves of surgical failure were analyzed and compared between UG and POAG. RESULTS: The mean follow-up periods (±SD) for UG and POAG were 104.8±44.0 and 98.1±36.3 months ( P =0.23), respectively. Mean preoperative IOP in UG and POAG were 34.9±11.0 and 25.3±9.4 mm Hg ( P <0.001), respectively. After surgery, mean IOP in UG and POAG decreased to 12.0±4.1 and 13.8±3.2 mm Hg, respectively, at 60 months, and 12.1±5.6 and 12.4±1.8 mm Hg ( P =0.86), respectively, at 120 months. The Kaplan-Meier survival curve analysis showed no significant differences in success rates between UG and POAG at the end of the follow-up (Log-rank test, P =0.13). Success rates in UG and POAG were 70.0 and 62.5% at 60 months, and 67.5 and 41.2% at 120 months, respectively. CONCLUSION: These results suggest that S-LOT is effective for UG and POAG alike.

Cerebrospinal fluid hypovolemia syndrome mimicking ocular myasthenia gravis: A case report.
Akihiro Shinkai, Yasuhiro Shinmei, Akihiro Takahashi, Kayoko Nakamura, Yoshiaki Tagawa, Shinki Chin, Susumu Ishida
American journal of ophthalmology case reports, 26, 101478, 101478, 2022年06月, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: Cerebrospinal fluid hypovolemia syndrome (CHS) is a rare clinical entity that can be caused by spontaneous cerebrospinal fluid (CSF) leakage. The aim of this study is to report a rare case of CHS after a traffic accident in a patient who presented with diplopia and ptosis with fluctuation and was initially diagnosed with ocular myasthenia gravis. OBSERVEATIONS: A 29-year-old man exhibited fluctuating left ptosis and diplopia after a traffic accident. Although he was suspected of having myasthenia gravis and was treated using oral pyridostigmine bromide, his symptoms did not improve. He also had orthostatic headaches and malaise after the accident. His symptoms were suspected to be associated with traumatic cerebrospinal fluid hypovolemia. After 1000-mL fluid replacement, his diplopia and ptosis improved, and orbital T2-weghted MRI detected a high-signal zone around the optic nerve. We diagnosed him with oculomotor nerve paresis associated with cerebrospinal fluid hypovolemia. The symptoms, including ptosis, diplopia, orthostatic headaches, and malaise, disappeared after epidural blood patch therapy. CONCLUSIONS AND IMPORTANCE: When treating patients with fluctuating ocular symptoms, such as diplopia and ptosis, who have a history of trauma and orthostatic headaches, the possibility of CHS should be considered in the differential diagnosis.

Alterations of choroidal circulation and vascular morphology in a patient with chronic myeloid leukemia before and after chemotherapy.
Mizuho Mitamura, Satoru Kase, Kiriko Hirooka, Hiroaki Endo, Yuki Ito, Yuko Cho, Susumu Ishida
BMC ophthalmology, 22, 1, 160, 160, 2022年04月07日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Chronic myeloid leukemia (CML) is known to cause leukemic retinopathy due to leukemia cell invasion into the choroid; however, details of the circulatory dynamics and morphological changes in the choroid are unknown. The aim of this study was to present a case of leukemic retinopathy and examine choroidal circulatory and structural analyses using laser speckle flowgraphy (LSFG) and optical coherence tomography with a binarization method, respectively. CASE PRESENTATION: A 15-year-old male diagnosed with CML complained of blurred vision in his right eye. He was ophthalmologically diagnosed with leukemic retinopathy due to retinal hemorrhage in both eyes. Tyrosine kinase inhibitors achieved complete cytogenetic remission and resolution of retinal hemorrhages at 6 months after treatment. After the treatment, the best-corrected visual acuity had recovered from 0.1 to 1.2 oculus dexter (OD) and remained at 1.5 oculus sinister (OS). The rate of change in macular blood flow assessed by the mean blur rate on LSFG was 18.3% increase OD and 25.2% decrease OS 19 months after treatment. The central choroidal thickness showed 0.4 and 3.1% reductions OD and OS, respectively. The binarization technique demonstrated that the rate of luminal areas in choroidal areas exhibited 3.2% increase OD but 4.8% decrease OS. CONCLUSION: Choroidal blood flow improved OD after treatment for CML, while it deteriorated OS, together with choroidal thinning due to reduction of luminal areas. The degrees of leukemia cell invasion into the choroidal tissue and tissue destruction might be different between the eyes in this case.

人を惹きつける魅力的なプレゼンをめざそう!
石田 晋, 小沢 洋子, 近藤 峰生, 園田 康平, 中澤 徹, 安川 力, 山城 健児
Retina Medicine, 11, 1, 1, 8, (株)先端医学社, 2022年04月
日本語

Serum advanced glycation end-products and αB-crystallin in diabetic retinopathy patients.
Taku Yamamoto, Satoru Kase, Miyuki Murata, Susumu Ishida
Biomedical reports, 16, 4, 28, 28, 2022年04月, ［国際誌］
英語, 研究論文（学術雑誌）, αB-crystallin, one of the small heat shock proteins, which is also known as HSPB5, has cytoprotective effects under inflammatory conditions. Advanced glycation end-products (AGE) are produced through non-enzymatic glycation under conditions of hyperglycemia and they contribute to angiogenesis and inflammation. The aim of this study was to examine the levels of serum αB-crystallin and AGE concentrations in blood samples collected from proliferative diabetic retinopathy (PDR) patients. Blood samples were collected from seven diabetic patients with PDR and eight patients without diabetes mellitus who underwent vitrectomy due to PDR and idiopathic macular diseases, respectively, in a single center. The levels of serum αB-crystallin and AGE were measured by ELISA and correlations were assessed statistically. The serum levels (mean ± SEM) of AGE were significantly higher in PDR patients (28.41±0.46 µg/ml) than in patients with non-diabetic macular diseases (25.76±0.60 µg/ml; P=0.015), whereas there was no significant difference in serum αB-crystallin levels. There was one patient with an extremely high level of αB-crystallin, who was treated with systemic corticosteroid due to chronic autoimmune inflammatory diseases. The current prospective study showed that serum AGE levels were significantly higher in PDR patients; however, no correlations between serum AGE and αB-crystallin levels were identified.

Diagnostic Accuracy of Cell Block Preparations and Clinical Features Affecting It in Vitreoretinal Lymphoma.
Satoru Kase, Kenichi Namba, Daiju Iwata, Kazuomi Mizuuchi, Kayo Suzuki, Takako Ito, Keitaro Hase, Nobuyoshi Kitaichi, Susumu Ishida
Journal of clinical medicine, 11, 5, 2022年03月03日, ［国際誌］
英語, 研究論文（学術雑誌）, Purpose: The purpose of this study was to examine the diagnostic accuracy of the cell block (CB) method and clinical features affecting it in patients with vitreoretinal lymphoma (VRL). Methods: This study enrolled 38 eyes in 33 VRL patients, and 7 eyes in 7 patients with idiopathic uveitis who underwent diagnostic vitrectomy. Medical records including the results of CB cytology, interleukin (IL)-10/-6 concentrations, and immunoglobulin heavy chain gene (IgH) rearrangement were retrospectively searched. Results: Patients with VRL comprised 16 women and 17 men, and the age of onset ranged from 44 to 85 years (mean: 70 years). CB preparations detected large malignant cells in 35 eyes (92%), whereas the other 3 VRL eyes were negative. Two of the latter three eyes showed subretinal infiltrates, which existed in 7 of 35 CB-positive eyes. Intravitreal IL-10 and -6 concentrations were 1866 ± 4088 pg/mL and 98 ± 139 pg/mL, respectively, and the rate of IL-10/-6 >1 was 86.9%. The presence of IgH monoclonality was 63.2%. In patients with uveitis, CB specimens revealed no atypical but small inflammatory cells. IL-6 concentration was 311.1 ± 240 pg/mL, whereas IL-10 was undetectable in six eyes, and the IL-negative rate was 85.7%. Six eyes (85.7%) with uveitis showed no IgH monoclonality. Conclusions: Diagnostic accuracy of CB preparations in VRL could achieve an equivalent outcome to IL ratio calculation and IgH monoclonality detection. The appearance of subretinal infiltrates may diminish the CB positivity.

Posterior scleritis with anti-neutrophil cytoplasmic antibody-associated vasculitis utilizing rituximab therapy to maintain remission: A case report.
Xinyu Weng, Daiju Iwata, Kenichi Namba, Kayo Suzuki, Kazuomi Mizuuchi, Hiroyuki Nakamura, Tatsuya Atsumi, Susumu Ishida
American journal of ophthalmology case reports, 25, 101333, 101333, 2022年03月, ［国際誌］
英語, PURPOSE: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a necrotizing vasculitis syndrome characterized by the destruction of small vessels, leading to various organ disorders. Here, we report a case of posterior scleritis with AAV successfully treated with prednisolone and rituximab (RTX) combination therapy. OBSERVATIONS: A 69-year-old female suffered from ocular pain and redness in her left eye for 2.5 years. She had been diagnosed with idiopathic otitis media before a year. At her initial visit, scleral injection with nodular elevated scleral lesions, vitreous haze, and serous retinal detachment (SRD) in the inferior periphery were observed in the left eye. Enhanced computed tomography revealed the enhancement and thickening of the left sclera. The results of laboratory analysis were positive for myeloperoxidase ANCA. Accordingly, she was diagnosed with AAV. Owing to the exacerbation of vitreous haze and SRD, topical treatment and steroid pulse therapy were initiated. Following therapy, anterior and posterior scleritis improved, and additional RTX was administered to maintain the remission. Following treatment, the patient has maintained remission with 10 mg/day prednisolone to date. CONCLUSIONS AND IMPORTANCE: We encountered a case of posterior scleritis with AAV in which inflammatory manifestations subsided with RTX and glucocorticoid combination therapy. RTX administration likely contributed to the maintenance of remission.

A case of Epstein-Barr virus acute retinal necrosis successfully treated with foscarnet.
Kayo Suzuki, Kenichi Namba, Keitaro Hase, Kazuomi Mizuuchi, Daiju Iwata, Takako Ito, Nobuyoshi Kitaichi, Hiroshi Takase, Susumu Ishida
American journal of ophthalmology case reports, 25, 101363, 101363, 2022年03月, ［国際誌］
英語, PURPOSE: Epstein-Barr virus (EBV) is a herpes virus known to cause infectious mononucleosis and several other human disorders. Ocular EBV infections that have been reported include uveitis, retinal vasculitis, and acute retinal necrosis (ARN). ARN is usually caused by herpes simplex virus (HSV) or varicella-zoster virus (VZV). ARN that is caused by EBV (EBV-ARN) is rarely seen, and only a few cases have been reported. The visual prognosis for EBV-ARN is poor, and no treatment strategy has been established. We report on a patient who was treated successfully for EBV-ARN. OBSERVATION: An 80-year-old female who had been treated with prednisolone at 5 mg/day and methotrexate at 2 mg/week for rheumatoid arthritis visited our hospital because of blurred vision in her left eye. Her left visual acuity was 20/50, and extensive white-yellowish retinal lesions at the temporal periphery with retinal hemorrhages were seen through vitreous haze. The DNA sequence of EBV, but not of HSV, VZV, or cytomegalovirus, was detected by a polymerase chain reaction (PCR) assay in the aqueous humor (4.2 × 106 copies/ml), with EBV also being positive in serum (3.5 × 102 copies/ml). The patient received 2 mg of intravitreal ganciclovir injections twice with a 3-day interval and intravenous infusion of acyclovir at 750 mg/day for 7 days; however, the retinal white lesions expanded rapidly, then dose of prednisolone was increased (40 mg/day) and vitrectomy was performed 10 days after the initial visit. After the surgery, the retinal lesion continued to enlarge. Vitreous samples showed high copies of EBV (1.2 × 108 copies/ml). Following treatment with intravenous foscarnet (4800 mg/day), which replaced the acyclovir application, the retinal white lesions gradually diminished, leaving retinal scars. To date, the patient has developed no retinal detachment and shows visual acuity over 6/60 in the left eye along with silicone oil. CONCLUSIONS: We experienced a case of EBV-ARN that was refractory to systemic acyclovir and topical ganciclovir but responded effectively to systemic foscarnet after vitrectomy. Although the clinical management remains challenging in this disease, foscarnet is considered to be one of the candidate drugs for EBV infections.

Laser speckle flowgraphy findings in a patient with radiation retinopathy.
Satoru Kase, Ayaka Hasegawa, Kiriko Hirooka, Hiroaki Endo, Kousuke Noda, Susumu Ishida
International journal of ophthalmology, 15, 1, 172, 174, 2022年, ［国際誌］
英語, 研究論文（学術雑誌）

Noninvasive Imaging of a Vasoproliferative Retinal Tumor Treated with Cryopexy.
Tetsuya Tanimukai, Kousuke Noda, Kiriko Hirooka, Satoru Kase, Susumu Ishida
Case reports in ophthalmology, 13, 2, 611, 616, 2022年, ［国際誌］
英語, 研究論文（学術雑誌）, Optical coherence tomographic angiography (OCTA) has emerged as a rapid, noninvasive imaging modality to visualize the vascular networks in the retina and choroid. Here, we report the clinical findings in a case of primary vasoproliferative retinal tumor (VPRT) observed by the wide-field swept-source OCTA. A 74-year-old male patient with central vision loss and metamorphopsia in his left eye was referred to our hospital. At the first visit, the best-corrected visual acuity was 20/20 OD and 20/40 OS. Fundus examination revealed the presence of the epiretinal membrane and inferotemporal reddish retinal tumor in the left eye. Fluorescein angiography and indocyanine green angiography (ICGA) showed leaky characteristics and sharply defined structure of vessels in the retinal tumor, respectively. The patient was diagnosed with the VPRT with secondary epiretinal membrane and underwent pars plana vitrectomy with internal limiting membrane peeling, retinal photocoagulation, and triple freeze and thaw procedure using cryopexy. Whereas wide-field swept-source OCTA preoperatively depicted the flow signals as distinctive vascular structures similar to ICGA, the tumor color turned out to be ischemic white, and the flow signals detected by wide-field OCTA disappeared after the surgery, indicating that the freezing effect of transscleral cryopexy sufficiently reached the surface of the tumor. In sum, wide-field swept-source OCTA is a useful imaging modality that can be noninvasively and repetitively performed to determine the treatment effect in cases of peripheral retinal tumors such as VPRT.

The Expression of Matrix Metalloproteinases in Eyes with Intraocular Lymphoma.
Kanae Fukutsu, Satoru Kase, Daiju Iwata, Kayo Suzuki, Kenichi Namba, Susumu Ishida
Ocular immunology and inflammation, 30, 7-8, 1798, 1802, 2022年, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: The purpose of this study is to investigate matrix metalloproteinases (MMPs) expression in human intraocular lymphoma (IOL). METHODS: Two enucleated eyes and seven cell-block samples obtained from patients with IOL who underwent vitrectomy were used. Immunopathological examinations were performed for detection of MMP-2, MMP-9, and TIMP-4 expressions. RESULTS: In the enucleated eye with primary IOL (PIOL), MMP-2 was negative, and MMP-9 and TIMP-4 were positive in the lymphoma cells, while in the enucleated eye with secondary IOL (SIOL), all the molecules were positive. Among the cell-block samples with PIOL, the positive rate in lymphoma cells of MMP-2, MMP-9, and TIMP-4 was 75%, 100%, and 75%, respectively. In the cell-block samples with SIOL, the positive rates of MMP-2, MMP-9, and TIMP-4 were all 100%. CONCLUSIONS: MMP-2, MMP-9, and TIMP-4 were expressed in lymphoma cells using the specimens of human IOL, suggesting that MMPs may play an important role in the development of IOL.

Downregulation of AlphaB-crystallin in Retinal Pigment Epithelial Cells Exposed to Diabetes-related Stimuli In Vivo and In Vitro.
D I Wu, Satoru Kase, Y E Liu, Atsuhiro Kanda, Miyuki Murata, Susumu Ishida
In vivo (Athens, Greece), 36, 1, 132, 139, 2022年, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND/AIM: AlphaB-crystallin plays a pivotal role in many diseases. However, the involvement of alphaB-crystallin in retinal pigment epithelial (RPE) cells with diabetes stimuli remains unknown. The aim of this study is to examine the alterations of RPE cells and alphaB-crystallin expression in diabetic models in vivo and in vitro. MATERIALS AND METHODS: Diabetic conditions in mice were induced by streptozotocin (STZ). The thickness of the RPE/choroid complex was measured by optical coherence tomography (OCT). Periodic acid-Schiff (PAS) staining was used to investigate the choriocapillaris in histological sections of murine eyeballs and oxidative stress was evaluated using immunofluorescence with anti-4-hydroxynonenal (HNE) antibody. AlphaB-crystallin expression was examined in the RPE/choroid complex using ELISA. Real-Time PCR was performed to evaluate the alphaB-crystallin expression in cultured human RPE cells with high glucose or following advanced glycation end-products (AGE) stimulation. RESULTS: In diabetic mice, OCT-based RPE/choroidal layers were thickened 2 months after STZ stimulation, where PAS-positive dilated choriocapillaris was noted. Immunoreactivity of 4-HNE was strongly observed in the RPE layer, from which a significant number of RPE cells was lost. Meanwhile, alphaB-crystallin expression in 2-month STZ mice was significantly lower compared to controls. In accordance with these results, in vitro data showed that the alphaB-crystallin expression was also significantly lower in RPE cells with high glucose or following AGE stimulation compared to untreated cells. CONCLUSION: In both types of diabetic models the expression of alphaB-crystallin was found to be downregulated in RPE cells and was associated with increased levels of oxidative stress.

Imbalanced choroidal circulation in eyes with asymmetric dilated vortex vein
Kiriko Hirooka, Michiyuki Saito, Yui Yamashita, Yuki Hashimoto, Nobuhiro Terao, Hideki Koizumi, Kousuke Noda, Susumu Ishida
Japanese Journal of Ophthalmology, Springer Science and Business Media LLC, 2021年12月03日
研究論文（学術雑誌）

Gliotic opaque posterior hyaloid membrane separation: report of two cases
Fumio Hosaka, Wataru Saito, Satoru Kase, Susumu Ishida
BMC Ophthalmology, 21, 1, BioMed Central Ltd, 2021年12月01日
英語, 研究論文（学術雑誌）

Factors based on optical coherence tomography correlated with vision impairment in diabetic patients
Hiroaki Endo, Satoru Kase, Hikari Tanaka, Mitsuo Takahashi, Satoshi Katsuta, Yasuo Suzuki, Minako Fujii, Susumu Ishida, Manabu Kase
Scientific Reports, 11, 1, Nature Research, 2021年12月01日
英語, 研究論文（学術雑誌）

A case of pterygium-like proliferation containing postoperative limbal dermoid remnants: a clinicopathological study
Mizuho Mitamura, Satoru Kase, Takeshi Ohguchi, Susumu Ishida
BMC Ophthalmology, 21, 1, BioMed Central Ltd, 2021年12月01日
英語, 研究論文（学術雑誌）

Macrophage-like iPS-derived Suppressor Cells Reduce Th1-mediated Immune Response to a Retinal Antigen.
Keitaro Hase, Kenichi Namba, Haruka Wada, Hyuma Tsuji, Aoi Maeda, Tomoki Murata, Ryo Otsuka, Daiju Iwata, Atsuhiro Kanda, Kousuke Noda, Nobuyoshi Kitaichi, Ken-Ichiro Seino, Susumu Ishida
Current eye research, 46, 12, 1908, 1916, 2021年12月, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: To investigate the immunotherapeutic effects of macrophage-like induced pluripotent stem (iPS) cell-derived suppressor cells (SCs) in ocular immune response and experimental autoimmune uveoretinitis (EAU). METHODS: The genes of Oct3/4, Sox2, Klf4, and c-Myc were transferred to B cells enriched from the spleen cells of C57BL/6 mice by using retrovirus vectors. Transferred B cells were cultured for 17 days to obtain colonies of iPS cells. Through additional steps, iPS-SCs were induced. An antigen-specific T cell proliferation assay was performed with CD4+ T cells collected from draining lymph nodes of the mice immunized with human interphotoreceptor retinoid-binding protein (hIRBP) peptide and co-cultured with iPS-SCs. Cytokine concentrations in the culture supernatant were examined. Mice were immunized with hIRBP peptide to induce EAU. The iPS-SCs were administered into the mice one day before the induction of EAU. RESULTS: The iPS-SCs decreased hIRBP-specific T cell proliferation depending on the number of cells. Productions of tumor necrosis factor-α and interferon-γ were significantly decreased; however, transforming growth factor-β1, nitric oxide, interleukin (IL)-13, IL-17A, and IL-17 F levels were elevated in the supernatant when the collected T cells were co-cultured with iPS-SCs. The iPS-SCs had immunosuppressant effects even without cell-to-cell contact, and their effects were non-specific to the antigen preloaded on iPS-SCs. EAU was significantly milder in the mice administered iPS-SCs prior to immunization. CONCLUSIONS: Macrophage-like iPS-SCs reduced Th1 immune response to a retinal antigen and Th1-mediated EAU in mice. These results showed the possibility of the application of iPS technology to the treatment of noninfectious ocular inflammation, endogenous uveitis, in the future.

臨床報告 再発がみられた単純ヘルペスウイルス2型による急性網膜壊死の1例
清野 修平, 南場 研一, 水内 一臣, 岩田 大樹, 鈴木 佳代, 品川 真有子, 長谷 敬太郎, 石田 晋
臨床眼科, 75, 12, 1527, 1532, 株式会社医学書院, 2021年11月15日

Comparison of clinical characteristics in patients with acute zonal occult outer retinopathy according to anti-retinal antibody status
Yuki Hashimoto, Wataru Saito, Saho Kanaizumi, Michiyuki Saito, Kousuke Noda, Atsuhiro Kanda, Susumu Ishida
Graefe's Archive for Clinical and Experimental Ophthalmology, 259, 10, 2967, 2976, Springer Science and Business Media Deutschland GmbH, 2021年10月01日
英語, 研究論文（学術雑誌）

Expression of vascular endothelial growth factor-c in the trabecular meshwork of patients with neovascular glaucoma and primary open-angle glaucoma
Keitaro Hase, Satoru Kase, Atsuhiro Kanda, Yasuhiro Shinmei, Kousuke Noda, Susumu Ishida
Journal of Clinical Medicine, 10, 13, MDPI, 2021年07月01日
英語, 研究論文（学術雑誌）

Correction to: Development of cytomegalovirus retinitis after negative conversion of cytomegalovirus antigenemia due to systemic antiviral therapy (Graefe's Archive for Clinical and Experimental Ophthalmology, (2021), 259, 4, (971-978), 10.1007/s00417-020-05011-0)
Kayo Suzuki, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Takako Ito, Keitaro Hase, Nobuyoshi Kitaichi, Susumu Ishida
Graefe's Archive for Clinical and Experimental Ophthalmology, 259, 4, 1083, Springer Science and Business Media Deutschland GmbH, 2021年04月01日
英語, 研究論文（学術雑誌）

Development of cytomegalovirus retinitis after negative conversion of cytomegalovirus antigenemia due to systemic antiviral therapy
Kayo Suzuki, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Takako Ito, Keitaro Hase, Nobuyoshi Kitaichi, Susumu Ishida
Graefe's Archive for Clinical and Experimental Ophthalmology, 259, 4, 971, 978, Springer Science and Business Media Deutschland GmbH, 2021年04月01日
英語, 研究論文（学術雑誌）

アデノウイルス角結膜炎迅速診断キットの検出感度の比較検討
橋爪 芽衣, 青木 功喜, 八幡 信代, Gabriel Gonzalez, 石田 晋, 大野 重昭, 佐藤 精一, 高岡 晃教, 北市 伸義
臨床眼科, 75, 4, 442, 447, (株)医学書院, 2021年04月
日本語

海外からみた日本の眼科
石田 晋, 小沢 洋子, 近藤 峰生, 篠島 亜里, 園田 康平, 中澤 徹, 安川 力, 柳 靖雄, 山城 健児
Retina Medicine, 10, 1, 1, 8, (株)先端医学社, 2021年04月
日本語

Validation of systemic parameters for the diagnosis of ocular sarcoidosis
Kayo Suzuki, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Takako Ito, Keitaro Hase, Nobuyoshi Kitaichi, Susumu Ishida
Japanese Journal of Ophthalmology, 65, 2, 191, 198, Springer Japan, 2021年03月01日
英語, 研究論文（学術雑誌）

Recent Clinical Features of Intraocular Inflammation in Hokkaido, Japan - Comparison with the Previous Decade.
Daiju Iwata, Kenichi Namba, Taku Yamamoto, Kazuomi Mizuuchi, Wataru Saito, Shigeaki Ohno, Nobuyoshi Kitaichi, Susumu Ishida
Ocular immunology and inflammation, 1, 7, 2021年02月11日, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: This study aimed to investigate the clinical features of intraocular inflammation (uveitis) in Hokkaido and to assess the etiology trends in comparison with those of our previous survey. METHODS: We retrospectively reviewed the medical records of 1,616 new referral uveitis patients (1,020 females and 596 males) in Hokkaido University Hospital between 2004 and 2014. RESULTS: Sarcoidosis was the most frequent etiology (17.4%), followed by Vogt-Koyanagi-Harada disease (8.1%), Behçet's disease (4.5%), and human leukocyte antigen B27 -associated uveitis (2.5%). The etiologies in 48.7% of the patients were unclassified. Compared to the previous survey between 1994 and 2003, the rate of Behçet's disease decreased and that of sarcoidosis increased. The rates of infectious uveitis and vitreoretinal lymphoma increased. CONCLUSION: Although the order of the top four etiologies was the same in the two surveys, the rate of sarcoidosis increased and that of Behçet's disease decreased.

Hypoxia Induces Galectin-1 Expression Via Autoinduction of Placental Growth Factor in Retinal Pigment Epithelium Cells.
Taku Yamamoto, Atsuhiro Kanda, Satoru Kase, Susumu Ishida
Investigative ophthalmology & visual science, 62, 2, 22, 22, 2021年02月01日, ［国際誌］
英語, 研究論文（学術雑誌）, Purpose: Galectin-1/LGALS1, a β-galactoside-binding protein, contributes to angiogenesis and fibrosis in various ocular diseases. Hypoxia-dependent and -independent pathways upregulate galectin-1/LGALS1 expression in Müller glial cells. Here, we present novel findings on the galectin-1/LGALS1 regulatory system in human retinal pigment epithelium (RPE) cells, the major cellular participant in the pathogenesis of neovascular age-related macular degeneration (nAMD). Methods: Human RPE cells were used to evaluate changes in gene and protein expression with real-time quantitative PCR and immunoblot analyses, respectively. The promoter and enhancer regions of LGALS1 were analyzed by reporter assay and chromatin immunoprecipitation. Immunofluorescence analysis of nAMD patient specimens was used to confirm the in vitro findings. Results: Hypoxia induced galectin-1/LGALS1 expression via binding of hypoxia-inducible factor 1α (HIF-1α) to hypoxia-responsive elements in the LGALS1 promoter region. Blockade of vascular endothelial growth factor receptor 1 (VEGFR1) partially decreased hypoxia-induced galectin-1/LGALS1 expression. Among several VEGFR1 ligands induced by hypoxia, placental growth factor (PlGF)/PGF alone upregulated galectin-1/LGALS1 expression via phosphorylation of activator protein 1 (AP-1) subunits following AKT and p38 mitogen-activated protein kinase (MAPK) activation. An AP-1 site in the LGALS1 enhancer region was required for PlGF-induced galectin-1/LGALS1 expression in RPE cells. PlGF application upregulated PGF expression via extracellular signal-regulated kinase 1 and 2, AKT, and p38 MAPK pathways. nAMD patient specimens demonstrated co-localization of galectin-1 with HIF-1α, PlGF, and VEGFR1 in RPE cells. Conclusions: Our present findings implicate the significance of hypoxia as a key inducer of galectin-1/LGALS1 in RPE cells and the autoinduction of hypoxia-induced PlGF as a vicious cycle amplifying the pathogenesis of nAMD.

A Novel Deep Learning Architecture for Vascular Area Measurement in Fundus Images
Kanae Fukutsu, Michiyuki Saito, Kousuke Noda, Miyuki Murata, Satoru Kase, Ryosuke Shiba, Naoki Isogai, Yoshikazu Asano, Nagisa Hanawa, Mitsuru Dohke, Manabu Kase, Susumu Ishida
Ophthalmology Science, 100004, 100004, Elsevier BV, 2021年02月
研究論文（学術雑誌）

Clinical Features of Primary Vitreoretinal Lymphoma: A Single-center Study.
Satoru Kase, Kenichi Namba, Daiju Iwata, Kazuomi Mizuuchi, Takako Ito, Keitaro Hase, Kayo Suzuki, Masahiro Onozawa, Nobuyoshi Kitaichi, Susumu Ishida
Cancer diagnosis & prognosis, 1, 2, 69, 75, 2021年, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND/AIM: This study aimed to demonstrate the clinical outcomes of primary vitreoretinal lymphoma (PVRL). PATIENTS AND METHODS: Seventeen patients with PVRL who had been treated at Hokkaido University Hospital were enrolled in this study. They were diagnosed based on their cytology, interleukin-10/-6 ratio, and immunoglobulin heavy chain (IgH) gene rearrangement. RESULTS: Diagnostic tests detected cytological malignancy among 14 cases (82.3%), high interleukin-10/-6 ratios among 16 cases (94.1%), and IgH monoclonality in 13 cases (76.5%). Systemic corticosteroids were given to seven (41.2%) patients before their diagnosis of PVRL. Treatments after diagnosis comprised intravitreal methotrexate injection, local radiation, and intravenous chemotherapy for 11, seven, and five cases, respectively. Central nervous system and systemic involvements were observed in nine and one case, respectively, and these complications occurred at 3 to 43 months (mean=16 months) after initial ocular presentation. CONCLUSION: Many of our patients did not receive any systemic intervention, and almost half of patients with PVRL developed central nervous system involvement during their follow-up period.

Optic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy
Yui Yamashita, Yuki Hashimoto, Kenichi Namba, Kazuomi Mizuuchi, Susumu Ishida
Case Reports in Ophthalmology, 899, 908, S. Karger AG, 2021年
英語, 研究論文（学術雑誌）

A case of pleomorphic adenoma of the lacrimal gland invading the lower orbit
Ryosei Kado, Satoru Kase, Yuka Suimon, Susumu Ishida
Orbit (London), Taylor and Francis Ltd., 2021年
英語, 研究論文（学術雑誌）

Involvements of choroidal vascular structures with local treatments in patients with diabetic macular edema
Satoru Kase, Hiroaki Endo, Mitsuo Takahashi, Masahiko Yokoi, Yuki Ito, Satoshi Katsuta, Shozo Sonoda, Taiji Sakamoto, Susumu Ishida, Manabu Kase
European Journal of Ophthalmology, SAGE Publications Ltd, 2021年
英語, 研究論文（学術雑誌）

Follicular lymphoma of the ocular adnexa: Clinicopathological findings with flow cytometry analysis of eight cases
Mizuho Mitamura, Satoru Kase, Yasuo Suzuki, Takatoshi Sakaguchi, Yuka Suimon, Yoko Dong, Kanako C Hatanaka, Toshiya Sinohara, Manabu Kase, Susumu Ishida
European Journal of Ophthalmology, SAGE Publications Ltd, 2021年
英語, 研究論文（学術雑誌）

A case of pediatric orbital fracture with successful recovery after elective surgery
Sakura Akaoka, Yasuhiro Shinmei, Masayuki Osawa, Ayaka Hasegawa, Kayo Suzuki, Akihiro Shinkai, Yuka Suimon, Yoshiaki Tagawa, Susumu Ishida
Neuro-Ophthalmology Japan, 38, 1, 25, 29, Neuro-Ophthalmology Society of Japan, 2021年
日本語, 研究論文（学術雑誌）

Optical coherence tomography as a possible tool to monitor and predict disease progression in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes
Akihiro Shinkai, Yasuhiro Shinmei, Kiriko Hirooka, Yoshiaki Tagawa, Kayoko Nakamura, Shinki Chin, Susumu Ishida
Mitochondrion, 56, 47, 51, Elsevier B.V., 2021年01月01日
英語, 研究論文（学術雑誌）

ROCK1 Mediates Retinal Glial Cell Migration Promoted by Acrolein.
Kanae Fukutsu, Miyuki Murata, Kasumi Kikuchi, Shiho Yoshida, Kousuke Noda, Susumu Ishida
Frontiers in medicine, 8, 717602, 717602, 2021年, ［国際誌］
英語, 研究論文（学術雑誌）, Objective: Acrolein is a highly reactive aldehyde that covalently binds to cellular macromolecules and subsequently modulates cellular function. Our previous study demonstrated that acrolein induces glial cell migration, a pathological hallmark of diabetic retinopathy; however, the detailed cellular mechanism remains unclear. The purpose of this study was to investigate the role of acrolein in retinal glial cell migration by focusing on rho-associated coiled-coil-containing protein kinases (ROCKs). Methods: Immunofluorescence staining for ROCK isoforms was performed using sections of fibrovascular tissue obtained from the eyes of patients with proliferative diabetic retinopathy (PDR). Rat retinal Müller glial cell line, TR-MUL5, was stimulated with acrolein and the levels of ROCK1 were evaluated using real-time PCR and western blotting. Phosphorylation of the myosin-binding subunit of myosin light chain phosphatase [myosin phosphatase target subunit 1, (MYPT1)] and myosin light chain 2 (MLC2) was assessed. The cell migration rate of TR-MUL5 cells exposed to acrolein and/or ripasudil, a non-selective ROCK inhibitor, was measured using the Oris cell migration assay. Results: ROCK isoforms, ROCK1 and ROCK2, were positively stained in the cytosol of glial cells in fibrovascular tissues. In TR-MUL5 cells, the mRNA expression level of Rock1, but not Rock2, was increased following acrolein stimulation. In line with the PCR data, western blotting showed increase in ROCK1 and cleaved ROCK1 protein in TR-MUL5 cells stimulated with acrolein. N-acetylcysteine (NAC) suppressed acrolein-associated Rock1 upregulation in TR-MUL5 cells. Acrolein augmented the phosphorylation of MYPT1 and MLC2 and increased the cell migration rate of TR-MUL5 cells, both of which were abrogated by ripasudil. Conclusions: Our study demonstrated that ROCK1 mediates the migration of retinal glial cells promoted by the unsaturated aldehyde acrolein.

Surgical Outcomes of Trabeculectomy in Uveitic Glaucoma: A Long-Term, Single-Center, Retrospective Case-Control Study.
Rina Kanaya, Riki Kijima, Yasuhiro Shinmei, Akihiro Shinkai, Takeshi Ohguchi, Kenichi Namba, Shinki Chin, Susumu Ishida
Journal of ophthalmology, 2021, 5550776, 5550776, 2021年, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: To evaluate the long-term outcomes of trabeculectomy with mitomycin C (MMC-TLE) in patients with uveitic glaucoma (UG). Patients and Methods. This was a retrospective, nonrandomized case series study. MMC-TLE was performed on 50 eyes with UG between February 2001 and January 2015 at Hokkaido University Hospital. Age- and sex-matched patients with primary open angle glaucoma (POAG) who underwent MMC-TLE were matched by age and sex and enrolled as controls. Surgical success was defined as an intraocular pressure (IOP) less than 18 or 15 mmHg. The Kaplan-Meier survival curves for surgical failure were analyzed. RESULTS: The mean preoperative IOP in UG and POAG was 27.6 ± 10.6 and 18.0 ± 4.5 mmHg, respectively. After the surgery, the mean IOP in UG and POAG was reduced to 11.7 ± 4.2 and 12.2 ± 3.8 mmHg at 12 months, 11.9 ± 7.0 and 12.1 ± 3.1 mmHg at 36 months, and 13.0 ± 5.2 and 10.6 ± 1.2 mmHg at 120 months, respectively. The success rates (IOP <18 mmHg, IOP reduction >20%) in UG and POAG were 91.7% and 88.0% at 12 months, 82.2% and 75.6% at 36 months, and 66.5% and 61.8% at 120 months, respectively. The success rates (IOP <15 mmHg) in UG and POAG were 64.0% and 58.0% at 12 months, 55.1% and 45.5% at 36 months, and 47.9% and 37.8% at 120 months, respectively. There was no significant difference in the success rate between UG and POAG at 120 months after surgery by either definition of surgical success. CONCLUSIONS: MMC-TLE effectively reduced IOP in both UG and POAG. There was no significant difference in the success rate between UG and POAG. Following sufficient inflammation suppression, surgical outcomes of UG may be comparable with those of POAG.

Cerebrospinal fluid hypovolemia syndrome after a traffic accident with abnormal eye movements: A case report
Yasuhiro Shinmei, Akihiro Takahashi, Kayoko Nakamura, Akihiro Shinkai, Yoshiaki Tagawa, Shinki Chin, Susumu Ishida
American Journal of Ophthalmology Case Reports, 20, Elsevier Inc., 2020年12月01日
英語, 研究論文（学術雑誌）

Multiple evanescent white dot syndrome and panuveitis: a case report
Kazuomi Mizuuchi, Wataru Saito, Kenichi Namba, Susumu Ishida
Journal of Ophthalmic Inflammation and Infection, 10, 1, Springer Science and Business Media Deutschland GmbH, 2020年12月01日
英語, 研究論文（学術雑誌）

Involvement of Müller Glial Autoinduction of TGF-β in Diabetic Fibrovascular Proliferation Via Glial-Mesenchymal Transition.
Di Wu, Atsuhiro Kanda, Ye Liu, Kousuke Noda, Miyuki Murata, Susumu Ishida
Investigative ophthalmology & visual science, 61, 14, 29, 29, 2020年12月01日, ［国際誌］
英語, 研究論文（学術雑誌）, Purpose: Müller glial-mesenchymal transition (GMT) is reported as the fibrogenic mechanism promoted by TGF-β-SNAIL axis in Müller cells transdifferentiated into myofibroblasts. Here we show the multifaceted involvement of TGF-β in diabetic fibrovascular proliferation via Müller GMT and VEGF-A production. Methods: Surgically excised fibrovascular tissues from the eyes of patients with proliferative diabetic retinopathy were processed for immunofluorescence analyses of TGF-β downstream molecules. Human Müller glial cells were used to evaluate changes in gene and protein expression with real-time quantitative PCR and ELISA, respectively. Immunoblot analyses were performed to detect TGF-β signal activation. Results: Müller glial cells in patient fibrovascular tissues were immunopositive for GMT-related molecular markers, including SNAIL and smooth muscle protein 22, together with colocalization of VEGF-A and TGF-β receptors. In vitro administration of TGF-β1/2 upregulated TGFB1 and TGFB2, both of which were suppressed by inhibitors for nuclear factor-κB, glycogen synthase kinase-3, and p38 mitogen-activated protein kinase. Of the various profibrotic cytokines, TGF-β1/2 application exclusively induced Müller glial VEGFA mRNA expression, which was decreased by pretreatment with small interfering RNA for SMAD2 and inhibitors for p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Supporting these findings, TGF-β1/2 stimulation to Müller cells increased the phosphorylation of these intracellular signaling molecules, all of which were also activated in Müller glial cells in patient fibrovascular tissues. Conclusions: This study underscored the significance of Müller glial autoinduction of TGF-β as a pathogenic cue to facilitate diabetic fibrovascular proliferation via TGF-β-driven GMT and VEGF-A-driven angiogenesis.

Acute unilateral inner retinal dysfunction with photophobia: importance of electrodiagnosis.
Toshiaki Hirakata, Kaoru Fujinami, Wataru Saito, Atsuhiro Kanda, Akito Hirakata, Susumu Ishida, Akira Murakami, Kazushige Tsunoda, Yozo Miyake
Japanese journal of ophthalmology, 65, 1, 42, 53, 2020年11月12日, ［国内誌］
英語, 研究論文（学術雑誌）, PURPOSE: To establish with negative electroretinogram (ERG) the clinical entity of eight patients with unilateral severe photophobia, essentially normal fundus, good visual acuity, and severe cone and rod dysfunction. STUDY DESIGN: Multicenter retrospective observation case series. METHODS: Comprehensive ophthalmologic examinations were performed, including best-corrected visual acuity (BCVA), full-field ERGs and multifocal ERGs (mfERGs), fundus photographs, and OCT. Systemic and genetic examinations were performed. RESULTS: The mean (± SD) age at the onset was 60.0 ± 8.4 years, and the six patients noticed severe photophobia in the affected eye in spite of almost normal fundus appearance and good BCVA. The dark-adapted bright flash ERGs in the affected eye had relatively well-preserved a-waves and depressed b-waves, i.e., a negative ERG. Cone ERGs and both b- and d-waves of the photopic long-duration ERGs were almost undetectable. Rod ERGs were severely reduced; however, only two patients complained of night blindness. In five patients, the mfERGs were extinguished in the periphery but preserved in the central retina, resulting in good BCVA. Electrophysiological findings indicated a severe diffuse dysfunction of the inner retina affecting bipolar cells of both ON- and OFF-pathways, and in five patients there was a reduction in the thickness of the inner nuclear layer. In seven patients the retinal arteries were attenuated. Anti-retinal antibodies were detected in the serum of two patients. No genetic causes were found. CONCLUSIONS: The common features in the eight patients with unilateral negative ERGs suggest a new disease entity of unilateral acute inner retinal layer dysfunction. In most patients, the only subjective complain was photophobia.

Morphological features of macular telangiectasia type 2 in Japanese patients.
Akihiro Shinkai, Wataru Saito, Yuki Hashimoto, Michiyuki Saito, Satoru Kase, Kousuke Noda, Susumu Ishida
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2020年11月04日, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: This study aimed to demonstrate the clinical course of Japanese patients with macular telangiectasia type 2 (MacTel-2). METHODS: This retrospective observational case series included 16 eyes of 8 Japanese patients (3 men and 5 women) with MacTel-2. The mean age and follow-up duration was 66.9 years and 42.8 months, respectively. Differences in best-corrected visual acuity (BCVA), funduscopic macular findings, central macular thickness (CMT), and the length of macular ellipsoid zone (EZ) loss were compared between the initial/baseline and final visits. Optical coherence tomographic changes in CMT by ≥ 20% and in EZ loss by ≥ 20% or ≥ 100 μm were defined as improved or worsened. RESULTS: Numerical changes in BCVA and EZ loss during follow-up were not statistically significant. However, the mean CMT at baseline, which was lower than that of healthy control eyes (P < 0.001), significantly increased during follow-up (P = 0.041). A certain proportion of eyes showed improvement in several parameters: funduscopic findings (both parafoveal retinal graying and foveal retinal pigment epithelium depigmentation) in 29% of eyes, CMT in 21% of eyes, and EZ loss in 43% of eyes. CONCLUSIONS: The non-negligible proportion of eyes with improved parameters, marked especially by macular EZ loss, suggests that Japanese patients with MacTel-2 have milder clinical features than Caucasian patients reported in the literature.

Solitary Fibrous Tumor of the Orbit: A Clinicopathologic Study of Two Cases with Review of the Literature
Mizuho Mitamura, Satoru Kase, Yasuo Suzuki, Takatoshi Sakaguchi, Yuka Suimon, Yoko Dong, Kanako C. Hatanaka, Toshiya Sinohara, Manabu Kase, Susumu Ishida
In Vivo, 34, 6, 3649, 3654, International Institute of Anticancer Research, 2020年11月01日
英語, 研究論文（学術雑誌）

硝子体内鉄片異物を経前房的に摘出した3例
長谷川 綾華, 清水 啓史, 野田 航介, 廣岡 季里子, 柴田 有紀子, 石田 晋
臨床眼科, 74, 12, 1449, 1454, (株)医学書院, 2020年11月
日本語

硝子体内鉄片異物を経前房的に摘出した3例　　　　　　　　　　　　　　　
長谷川 綾華, 清水 啓史, 柴田 有紀子, 品川 真有子, 齋藤 理幸, 加瀬 諭, 野田 航介, 石田 晋
眼科臨床紀要, 13, 11, 739, 739, 眼科臨床紀要会, 2020年11月
日本語

脈絡膜瘢痕病巣を生じた急性特発性黄斑症の1例　　　　　　　　　　　　　　　
大田 翔一郎, 齋藤 理幸, 鈴木 智浩, 清水 啓史, 橋本 勇希, 加瀬 諭, 野田 航介, 石田 晋
眼科臨床紀要, 13, 11, 743, 743, 眼科臨床紀要会, 2020年11月
日本語

Pachychoroid関連疾患と鑑別を要したchoroidal macrovesselの1例　　　　　　　　　　　　　　　
片岡 慶次, 加瀬 諭, 長谷川 綾華, 柴田 有紀子, 品川 真有子, 清水 啓史, 齋藤 理幸, 野田 航介, 石田 晋
眼科臨床紀要, 13, 11, 749, 749, 眼科臨床紀要会, 2020年11月
日本語

ポリープ状脈絡膜血管症に対するphotodynamic therapyトリプル療法におけるpachychoroidの有無での治療成績の比較　　　　　　　　　　　　　　　
柴田 有紀子, 安藤 亮, 野田 航介, 廣岡 季里子, 長谷川 綾華, 品川 真有子, 清水 啓史, 齋藤 理幸, 加瀬 諭, 齋藤 航, 石田 晋
眼科臨床紀要, 13, 11, 752, 752, 眼科臨床紀要会, 2020年11月
日本語

増殖糖尿病網膜症患者の硝子体中アクロレイン結合蛋白と単球走化性因子　　　　　　　　　　　　　　　
村田 美幸, 福津 佳苗, 野田 航介, 吉田 志帆, 神田 敦宏, 石田 晋
糖尿病合併症, 34, Suppl.1, 262, 262, (一社)日本糖尿病合併症学会, 2020年11月
日本語

Laser Speckle Flowgraphy Findings in a Patient with Choroidal Macrovessel.
Keiji Kataoka, Satoru Kase, Kousuke Noda, Susumu Ishida
Ophthalmology. Retina, 4, 11, 1123, 1124, 2020年11月, ［国際誌］
英語, 研究論文（学術雑誌）

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect
Mizuho Mitamura, Satoru Kase, Kiriko Hirooka, Susumu Ishida
Oncotarget, 11, 42, 3800, 3804, Impact Journals LLC, 2020年10月20日
英語, 研究論文（学術雑誌）

機械学習によって自動算出された網膜動静脈面積と血圧脈波の関係　　　　　　　　　　　　　　　
福津 佳苗, 齋藤 理幸, 野田 航介, 村田 美幸, 加瀬 諭, 柴 涼介, 磯貝 直己, 道家 充, 石田 晋
眼科臨床紀要, 13, 10, 683, 684, 眼科臨床紀要会, 2020年10月
日本語

黄斑部毛細血管拡張症type 2患者の黄斑部脈絡膜厚評価　　　　　　　　　　　　　　　
新海 晃弘, 齋藤 航, 橋本 勇希, 齋藤 理幸, 野田 航介, 石田 晋
眼科臨床紀要, 13, 10, 684, 684, 眼科臨床紀要会, 2020年10月
日本語

抗carbonic anhydrase II抗体陽性自己免疫性網膜症の臨床像　　　　　　　　　　　　　　　
安藤 亮, 齋藤 航, 平形 寿彬, 藤波 芳, 角田 和繁, 加瀬 諭, 野田 航介, 神田 敦宏, 石田 晋
眼科臨床紀要, 13, 10, 684, 684, 眼科臨床紀要会, 2020年10月
日本語

Choroidal Thickness in Diabetic Patients Without Diabetic Retinopathy: A Meta-analysis.
Hiroaki Endo, Satoru Kase, Michiyuki Saito, Masahiko Yokoi, Mitsuo Takahashi, Susumu Ishida, Manabu Kase
American journal of ophthalmology, 218, 68, 77, 2020年10月, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: To evaluate the relationship between diabetic eyes without diabetic retinopathy and healthy eyes in subfoveal choroidal thickness. DESIGN: Systematic review and meta-analysis. METHODS: An independent retrospective or prospective clinical study comparing diabetic eyes without diabetic retinopathy and healthy control eyes in the subfoveal choroidal thickness was selected. This study compiled data from publications in PubMed and Web of Science between January 1, 2008, and November 15, 2019. Heterogeneity was statistically quantified by I2 statistics, and meta-analysis was performed using a random-effects model. RESULTS: Seventeen related studies were identified, including a total of 4,213 eyes, which consisted of 1,197 diabetic eyes without diabetic retinopathy and 3,016 healthy eyes. Meta-analysis clearly showed that the subfoveal choroidal thickness of diabetic eyes without retinopathy was significantly thinner than that of healthy control eyes (weighted mean difference = -14.34 μm; 95% confidence interval: -24.37 to -4.32 μm; P < .005). Similar results were obtained in sub-analysis based on the adjustment of the axial length. CONCLUSIONS: This study suggests that the subfoveal choroidal thickness was thin in diabetic eyes without retinopathy compared to healthy eyes. Subfoveal choroidal thickness might be an important parameter for the development of diabetic retinopathy in diabetic eyes without retinopathy.

機械学習によるFA画像からの網膜静脈分枝閉塞症の視力予後の推量　　　　　　　　　　　　　　　
品川 真有子, 齋藤 理幸, 高橋 光生, 伊藤 有希, 遠藤 弘毅, 加瀬 諭, 野田 航介, 石田 晋
眼科臨床紀要, 13, 9, 638, 638, 眼科臨床紀要会, 2020年09月
日本語

Outer Retinal Abnormalities in a Patient with Danon Disease.
Ayaka Hasegawa, Kousuke Noda, Akio Fujiya, Kiriko Hirooka, Toshihisa Anzai, Susumu Ishida
Retinal cases & brief reports, 2020年08月31日, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: To report outer retinal abnormalities evaluated using high-resolution imaging modalities in a patient with Danon disease. METHODS: Case report. RESULTS: A 26-year-old woman, diagnosed with Danon disease based on genetic testing, was referred to our department for further evaluation of ocular findings. Her best-corrected visual acuity was 20/20, and color vision was normal. Fundus examination revealed pigmentary changes consisting of mottled depigmentation and pigmentation in the peripheral retina of both eyes. Spectral-domain optical coherence tomography (SD-OCT) revealed disruptions of the ellipsoid and interdigitation zones, irregularity of the retinal pigment epithelium (RPE), and hyperreflectivity of the outer nuclear layer. In addition, an adaptive optics retinal camera demonstrated the ambiguous macular cone mosaic pattern. CONCLUSION: Danon disease is caused by a primary deficiency in lysosomal associated membrane protein 2 (LAMP-2), an important constituent of the lysosomal membrane that plays a crucial role in the process of autophagy. It is possible that the findings of SD-OCT and adaptive optics retinal camera are early changes associated with the accumulation of autophagosomes and/or phagosomes due to LAMP-2 dysfunction in the photoreceptors, eventually followed by outer retinal degeneration, such as thinning of both the photoreceptor and RPE layers at the fovea.

A case of metastatic iris tumor observed with anterior segment optical coherence tomography before and after radiation therapy
Mizuho Mitamura, Satoru Kase, Yuka Suimon, Takako Ito, Susumu Ishida
In Vivo, 34, 4, 2159, 2162, International Institute of Anticancer Research, 2020年08月01日
英語, 研究論文（学術雑誌）

Receptor-Associated Prorenin System in the Trabecular Meshwork of Patients with Primary Open-Angle Glaucoma and Neovascular Glaucoma.
Erdal Tan Ishizuka, Atsuhiro Kanda, Yasuhiro Shinmei, Takeshi Ohguchi, Yoshiaki Tagawa, Keitaro Hase, Taku Yamamoto, Kousuke Noda, Shinki Chin, Susumu Ishida
Journal of clinical medicine, 9, 8, 2020年07月22日, ［国際誌］
英語, 研究論文（学術雑誌）, The receptor-associated prorenin system (RAPS) is associated with several pathologic conditions, including diabetic retinopathy, age-related macular degeneration, and uveitis. Here, we show the involvement of RAPS in the trabecular meshwork (TM) from patients with primary open-angle glaucoma (POAG) and neovascular glaucoma (NVG) due to proliferative diabetic retinopathy. Anterior chamber (AC) levels of prorenin significantly increased in both POAG and NVG, as did those of angiotensin II in NVG alone, compared to cataract. In surgically excised TM tissues, (pro)renin receptor ((P)RR) and angiotensin II type 1 receptor (AT1R) co-localized with prorenin and angiotensinogen, respectively. In screening for various genes related to glaucoma, prorenin stimulation to human TM cells exclusively upregulated cell junction constituents connexin 43 and zona occludens 1, while downregulating an extracellular matrix-degrading enzyme tissue plasminogen activator, all of which were reversed by (P)RR blockade. In contrast, angiotensin II application upregulated a pro-angiogenic factor placental growth factor alone, which was abolished by AT1R blockade. Consistently, (P)RR and AT1R co-localized with these corresponding proteins in patient TM tissues. Oxidative stress, a known etiology for glaucoma, induced the expression of prorenin and angiotensinogen in human TM cells. These data suggest the contribution of RAPS to the molecular pathogenesis of POAG and NVG through TM tissue remodeling and AC angle angiogenesis.

Blockade of Platelet-Derived Growth Factor Signaling Inhibits Choroidal Neovascularization and Subretinal Fibrosis in Mice.
Ye Liu, Kousuke Noda, Miyuki Murata, Di Wu, Atsuhiro Kanda, Susumu Ishida
Journal of clinical medicine, 9, 7, 2020年07月15日, ［国際誌］
英語, 研究論文（学術雑誌）, Neovascular age related macular degeneration (nAMD) leads to severe vision loss worldwide and is characterized by the formation of choroidal neovascularization (CNV) and fibrosis. In the current study, we aimed to investigate the effect of blockade for platelet derived growth factor receptor-β (PDGFR-β) on the formation of choroidal neovascularization and fibrosis in the laser-induced CNV model in mice. Firstly, the presence of PDGFR-β in CNV lesions were confirmed. Intravitreal injection of PDGFR-β neutralizing antibody significantly reduced the size of CNV and subretinal fibrosis. Additionally, subretinal hyperreflective material (SHRM), a landmark feature on OCT as a risk factor for subretinal fibrosis formation in nAMD patients was also suppressed by PDGFR-β blockade. Furthermore, pericytes were abundantly recruited to the CNV lesions during CNV formation, however, blockade of PDGFR-β significantly reduced pericyte recruitment. In addition, PDGF-BB stimulation increased the migration of the rat retinal pericyte cell line, R-rPCT1, which was abrogated by the neutralization of PDGFR-β. These results indicate that blockade of PDGFR-β attenuates laser-induced CNV and fibrosis through the inhibition of pericyte migration.

A Case of IgG4-Related Ophthalmic Disease With Coronary Arteritis.
Yuka Suimon, Satoru Kase, Shuhei Shimoyama, Susumu Ishida
Ophthalmic plastic and reconstructive surgery, 2020年07月13日, ［国際誌］
英語, 研究論文（学術雑誌）, IgG4-related disease (IgG4-RD) is a fibro-inflammatory condition characterized by lymphoplasmacytic infiltrates rich in IgG4-positive plasma cells, often with elevated serum IgG4. Multiple organs may be affected. Coronary arteritis may be one form of fatal involvement in IgG4-RD. IgG4-RD can manifest as periocular lesions, called IgG4-related ophthalmic disease (IgG4-ROD). Here, the authors describe a patient with asymptomatic coronary arteritis detected after the diagnosis of IgG4-ROD. A 58-year-old male complained of eyelid swelling and diplopia without systemic symptoms. Swelling of bilateral lacrimal glands and infraorbital nerves, high serum IgG4 levels, and histopathology of lacrimal gland tissue fulfilled diagnostic criteria for IgG4-ROD. After diagnosis, systemic and coronary CT showed coronary lesions and coronary artery stenosis. After prednisolone at 40 mg/day was administered, swelling of the lacrimal glands, diplopia, and coronary lesions improved. This case emphasizes the importance of systemic screening, even if initial symptoms are solely associated with periocular regions.

Multimodal imaging in sclerochoroidal calcification: a case report and literature review.
Mizuho Mitamura, Satoru Kase, Susumu Ishida
BMC ophthalmology, 20, 1, 248, 248, 2020年06月22日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Sclerochoroidal calcification (SCC), a rare condition found in elderly people, is idiopathic or occasionally secondary to disorders affecting calcium metabolism. Findings of multimodal imaging including choroidal circulation are, however, largely unknown. We present a patient of SCC with systemic background, who underwent multimodal imaging evaluations. CASE PRESENTATION: A 70-year-old Japanese man was referred to our clinic because of bilateral fundus lesions. He had a history of chronic kidney disease (CKD) and secondary hyperparathyroidism. Fundus photography showed a cluster of choroidal folds in the superotemporal extra-macular region OS. Swept-source optical coherence tomography demonstrated ellipsoid zone disruption OD, retinal pigment epithelium undulation OS, dilated Haller layer veins OU, and central choroidal thickening OU and thinning of the overlying choroid due to scleral elevation OS. Fluorescein angiography detected macular hyperfluorescence OD. Indocyanine green angiography demonstrated choroidal vascular hyperpermeability together with numerous scattered hypofluorescent lesions OU. Fundus autofluorescence showed multiple hypoautofluorescent spots surrounded by hyperautofluorescent areas OD. Laser speckle flowgraphy exhibited choroidal blood flow reduction represented by a cold color pattern OU. B-mode echography displayed hyperechoic solid lesions with acoustic shadowing and orbital computed tomography revealed high density areas in the sclera, both of which were consistent with calcification. The patient was diagnosed with SCC, and these imaging findings remained unchanged 7 months after the diagnosis. CONCLUSIONS: We reported a case of SCC with the background of CKD. Our detailed multimodal observations indicated choroidal hypoperfusion possibly caused by mechanical compression due to calcium deposition in the sclera.

Regulation of Spermine Oxidase through Hypoxia-Inducible Factor-1α Signaling in Retinal Glial Cells under Hypoxic Conditions.
Di Wu, Kousuke Noda, Miyuki Murata, Ye Liu, Atsuhiro Kanda, Susumu Ishida
Investigative ophthalmology & visual science, 61, 6, 52, 52, 2020年06月03日, ［国際誌］
英語, 研究論文（学術雑誌）, Purpose: Acrolein, a highly reactive unsaturated aldehyde, is known to facilitate glial cell migration, one of the pathological hallmarks in diabetic retinopathy. However, cellular mechanisms of acrolein generation in retinal glial cells remains elusive. In the present study, we investigated the role and regulation of spermine oxidase (SMOX), one of the enzymes related to acrolein generation, in retinal glial cells under hypoxic condition. Methods: Immunofluorescence staining for SMOX was performed using sections of fibrovascular tissues obtained from patients with proliferative diabetic retinopathy. Expression levels of polyamine oxidation enzymes including SMOX were analyzed in rat retinal Müller cell line 5 (TR-MUL5) cells under either normoxic or hypoxic conditions. The transcriptional activity of Smox in TR-MUL5 cells was evaluated using the luciferase assay. Levels of acrolein-conjugated protein, Nε-(3-formyl-3,4-dehydropiperidino) lysine adduct (FDP-Lys), and hydrogen peroxide were measured. Results: SMOX was localized in glial cells in fibrovascular tissues. Hypoxia induced SMOX production in TR-MUL5 cells, which was suppressed by silencing of hypoxia-inducible factor-1α (Hif1a), but not Hif2a. Transcriptional activity of Smox was regulated through HIF-1 binding to hypoxia response elements 2, 3, and 4 sites in the promoter region of Smox. Generation of FDP-Lys and hydrogen peroxide increased in TR-MUL5 cells under hypoxic condition, which was abrogated by SMOX inhibitor MDL72527. Conclusions: The current data demonstrated that hypoxia regulates production of SMOX, which plays a role in the generation of oxidative stress inducers, through HIF-1α signaling in Müller glial cells under hypoxic condition.

Changes in choroidal blood flow velocity in patients diagnosed with central serous chorioretinopathy during follow-up for pachychoroid pigment epitheliopathy
Wataru Saito, Yuki Hashimoto, Kiriko Hirooka, Susumu Ishida
American Journal of Ophthalmology Case Reports, 18, Elsevier Inc, 2020年06月01日
英語, 研究論文（学術雑誌）

小児と成人のacute macular neuroretinopathyにおける網脈絡膜形態の比較　　　　　　　　　　　　　　　
橋本 勇希, 齋藤 航, 長谷川 裕香, 滝田 亜かり, 野田 航介, 吉冨 健志, 石田 晋
眼科臨床紀要, 13, 6, 431, 432, 眼科臨床紀要会, 2020年06月
日本語

Alteration of choroidal vascular structure in diabetic macular edema.
Satoru Kase, Hiroaki Endo, Mitsuo Takahashi, Yuki Ito, Michiyuki Saito, Masahiko Yokoi, Satoshi Katsuta, Shozo Sonoda, Taiji Sakamoto, Susumu Ishida, Manabu Kase
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 258, 5, 971, 977, 2020年05月, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: The aim of this study was to analyze choroidal structures in healthy subjects and patients with/without diabetic macular edema (DME). METHODS: This was a retrospective observation case control study. Four hundred and two eyes of patients with diabetes mellitus (DM), and 124 age-matched eyes of healthy subjects were enrolled in this study. DM patients were divided into 3 groups: presence of central-involved (CI) DME (n = 81) and nonCI-DME/non-DME (n = 321), based on OCT findings. Central choroidal thickness (CCT) and total choroidal, luminal, and stromal areas were determined using EDI-OCT and a binarization method, respectively. The luminal area expressed as a ratio of the total choroidal area was defined as the L/C ratio. RESULTS: DM eyes showed a significantly lower L/C ratio than control eyes, whereas there was no significant difference in CCT or total choroidal, luminal, or stromal areas. There was no significant difference between CI-DME and non-DME groups in HbA1c, blood pressure, dyslipidemia, or renal function. CCT and total choroidal, luminal, and stromal areas were significantly greater in the CI-DME group than non-DME group (each P < 0.05). CONCLUSIONS: These results suggest that CCT was thickened in the presence of DME, associated with both increased luminal and stromal areas, which might be related to the pathology of DME.

Non-paraneoplastic autoimmune retinopathy that developed in fellow eye 10 years after onset in first eye: a case report.
Gen Miura, Takayuki Baba, Takehito Iwase, Hisao Ohde, Atsuhiro Kanda, Wataru Saito, Susumu Ishida, Shuichi Yamamoto
BMC ophthalmology, 20, 1, 132, 132, 2020年04月06日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Evidence-based criteria for the treatment of autoimmune retinopathy (AIR) have not been established. The pathology and clinical features of each antibody causing AIR, and its long-term course are still undetermined. We report our findings in a case of non-paraneoplastic AIR (npAIR) that developed in the fellow eye 10 years after the onset in the first eye. CASE PRESENTATION: Our patient had photophobia in both eyes and a rapidly progressing visual field defect in his right eye at the initial examination. He was diagnosed with non-paraneoplastic AIR based on the clinical findings and immunoblot analyses for anti-retinal antibodies, and he was treated with steroids. Ten years later, a visual field defect developed in the fellow eye, and a diagnosis of npAIR was made. Immunoblot analyses were positive for anti-α-enolase antibodies. He was treated with steroids, immunosuppressants, and plasma exchange. However, the response to the treatment was poor and both eyes eventually became blind. CONCLUSIONS: As best we know, this is the first case report of npAIR that developed in the fellow eye over 10 years after the development in the first eye. Long-term follow-up and a search for tumor lesions are necessary in cases of npAIR. Further understanding of the long-term course of AIR can contribute to an understanding of the pathology and treatment of npAIR.

Glucocorticoid-transactivated TSC22D3 attenuates hypoxia- and diabetes-induced Müller glial galectin-1 expression via HIF-1α destabilization.
Atsuhiro Kanda, Ikuyo Hirose, Kousuke Noda, Miyuki Murata, Susumu Ishida
Journal of cellular and molecular medicine, 24, 8, 4589, 4599, 2020年04月, ［国際誌］
英語, 研究論文（学術雑誌）, Galectin-1/LGALS1, a newly recognized angiogenic factor, contributes to the pathogenesis of diabetic retinopathy (DR). Recently, we demonstrated that glucocorticoids suppressed an interleukin-1β-driven inflammatory pathway for galectin-1 expression in vitro and in vivo. Here, we show glucocorticoid-mediated inhibitory mechanism against hypoxia-inducible factor (HIF)-1α-involved galectin-1 expression in human Müller glial cells and the retina of diabetic mice. Hypoxia-induced increases in galectin-1/LGALS1 expression and promoter activity were attenuated by dexamethasone and triamcinolone acetonide in vitro. Glucocorticoid application to hypoxia-stimulated cells decreased HIF-1α protein, but not mRNA, together with its DNA-binding activity, while transactivating TSC22 domain family member (TSC22D)3 mRNA and protein expression. Co-immunoprecipitation revealed that glucocorticoid-transactivated TSC22D3 interacted with HIF-1α, leading to degradation of hypoxia-stabilized HIF-1α via the ubiquitin-proteasome pathway. Silencing TSC22D3 reversed glucocorticoid-mediated ubiquitination of HIF-1α and subsequent down-regulation of HIF-1α and galectin-1/LGALS1 levels. Glucocorticoid treatment to mice significantly alleviated diabetes-induced retinal HIF-1α and galectin-1/Lgals1 levels, while increasing TSC22D3 expression. Fibrovascular tissues from patients with proliferative DR demonstrated co-localization of galectin-1 and HIF-1α in glial cells partially positive for TSC22D3. These results indicate that glucocorticoid-transactivated TSC22D3 attenuates hypoxia- and diabetes-induced retinal glial galectin-1/LGALS1 expression via HIF-1α destabilization, highlighting therapeutic implications for DR in the era of anti-vascular endothelial growth factor treatment.

Alteration of Cell Surface Markers CD38 and CD138 in Lymphoproliferative Disorders in the Ocular Adnexa.
Yuka Suimon, Satoru Kase, Ichiro Miura, Kan Ishijima, Susumu Ishida
Anticancer research, 40, 4, 2019, 2023, 2020年04月, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND/AIM: CD38 is a cell surface marker commonly present in plasma cells and activated T cells, while CD138 is a representative plasma cell marker. The aim of this study was to describe the expression of cell surface markers including CD38 and CD138, in the tumors of patients with IgG4-related ophthalmic disease (IgG4-ROD) and extranodal marginal zone B-cell lymphoma (EMZL) of the ocular adnexa. MATERIALS AND METHODS: Twenty-four consecutive patients of whom 12 had IgG4-ROD and 12 EMZL were enrolled in this study. Medical records were reviewed for flow cytometry (FCM) results on conventional T-cell markers, B-cell markers, CD38 and CD138. RESULTS: Positive rates of T-cell markers, CD38 and CD138 were significantly higher in IgG4-ROD than in EMZL (p<0.01 and p<0.05, respectively). CONCLUSION: Our FCM results on CD38 and CD138 showed that the lymphocyte populations were different between IgG4-ROD and EMZL, which may reflect the different pathophysiology of the two diseases.

A Case of Recurrent Painful Ophthalmoplegic Neuropathy in a Child
Ai Sakuma, Hideaki Shiraishi, Yasuhiro Shinmei, Ryo Ando, Kiriko Hirooka, Tomoko Shiroeda, Kayo Suzuki, Kayoko Nakamura, Shinki Chin, Susumu Ishida
Neuro-Ophthalmology Japan, 37, 1, 51, 57, Neuro-Ophthalmology Society of Japan, 2020年03月25日
日本語, 研究論文（学術雑誌）

Pseudo-inflammatory manifestations of choroidal lymphoma resembling Vogt-Koyanagi-Harada disease: case report based on multimodal imaging.
Kanae Fukutsu, Kenichi Namba, Daiju Iwata, Kazuomi Mizuuchi, Satoru Kase, Kayo Suzuki, Hiroshi Shimizu, Yukiko Shibata, Fumihiko Yamawaki, Masahiro Onozawa, Susumu Ishida
BMC ophthalmology, 20, 1, 94, 94, 2020年03月10日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Hematologic malignancies occasionally cause serous retinal detachment (SRD); however, its pathogenesis remains unclear. Here we present the imaging characteristics of metastatic choroidal lymphoma masquerading as Vogt-Koyanagi-Harada (VKH) disease. CASE PRESENTATION: A 45-year-old Japanese woman was referred to our clinic because of bilateral SRD with blurred vision. Fluorescein angiography revealed multiple pinpoint leakage followed by pooling OU. Enhanced depth imaging optical coherence tomography showed marked choroidal thickening OU. Laser speckle flowgraphy detected choroidal circulation impairment OU. Although these results totally agreed with the inflammatory manifestations of acute VKH disease, indocyanine green angiography demonstrated various sizes of sharply marginated hypofluorescent lesions that seemed atypical for the finding of VKH disease, i.e., vaguely marginated hypofluorescent small dots. Cerebrospinal fluid pleocytosis was not detected. Blood tests revealed leukocytosis together with elevation of lactate dehydrogenase and soluble interleukin-2 receptor levels. Corticosteroid pulse therapy did not improve any ocular findings. Bone marrow biopsy was then performed, leading to a definite diagnosis of diffuse large B-cell lymphoma. After starting systemic chemotherapy, both SRD and choroidal thickening resolved rapidly with visual recovery. However, choroidal hypoperfusion persisted, which contrasted distinctly with the inflammatory pattern of VKH disease, i.e., the restoration of choroidal blood flow in parallel with normalization of choroidal thickness. CONCLUSIONS: Our detailed multimodal observations highlighted the differential imaging features of choroidal lymphoma despite close resemblance to VKH disease especially at the initial stage. Impaired circulation in the thickened choroid marked the pseudo-inflammatory pathogenesis of SRD due to choroidal involvement with neoplastic, but not inflammatory cells.

Waardenburg症候群と網膜芽細胞腫を合併した13番染色体長腕部分欠失の1例　　　　　　　　　　　　　　　
赤岡 さくら, 安藤 亮, 加瀬 諭, 外木 秀文, 長 祐子, 藤井 史彦, 太田 亨, 石田 晋
日本眼科学会雑誌, 124, 臨増, 231, 231, (公財)日本眼科学会, 2020年03月
日本語

SDT fattyラット水晶体におけるポリオール経路と酸化ストレスの継時的解析　　　　　　　　　　　　　　　
菊地 香澄, 村田 美幸, 野田 航介, 神田 敦宏, 加瀬 諭, 影山 靖, 篠原 雅巳, 笹瀬 智彦, 石田 晋
日本眼科学会雑誌, 124, 臨増, 242, 242, (公財)日本眼科学会, 2020年03月
日本語

アクロレインによる網膜ミュラーグリア細胞の遊走作用とROCK1の関与　　　　　　　　　　　　　　　
福津 佳苗, 村田 美幸, 野田 航介, 吉田 志帆, 神田 敦宏, 石田 晋
日本眼科学会雑誌, 124, 臨増, 275, 275, (公財)日本眼科学会, 2020年03月
日本語

Alteration of choroidal vascular structure in diabetic retinopathy.
Satoru Kase, Hiroaki Endo, Mitsuo Takahashi, Michiyuki Saito, Masahiko Yokoi, Yuki Ito, Satoshi Katsuta, Shozo Sonoda, Taiji Sakamoto, Susumu Ishida, Manabu Kase
The British journal of ophthalmology, 104, 3, 417, 421, 2020年03月, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: The aim of this study was to analyse choroidal structures in normal patients and patients with diabetes with various severities of diabetic retinopathy (DR). METHODS: This is a retrospective observation case control study. Three hundred and forty-two diabetic eyes, and age-matched 112 eyes without diabetes mellitus (DM) were enrolled in this study. Patients with DM were classified into no DR, mild/moderate non-proliferative DR (mNPDR), severe NPDR and proliferative DR (PDR). Patients with DM were further divided into two groups based on information regarding systemic DM treatment situation: DM-treated and untreated groups. Central choroidal thickness (CCT), and total choroidal area (TCA), luminal area (LA) and stromal area (SA) were determined using enhanced depth imaging optical coherence tomography and a binarisation method, respectively. The ratio of LA in the TCA was defined as L/C ratio. RESULTS: The haemoglobin A1c (HbA1c) value was significantly higher in the DM-untreated than in the DM-treated subjects. L/C ratio was significantly lower in all the diabetic eyes than control eyes (p<0.05). TCA, LA, L/C ratio and CCT were significantly greater in the DM-untreated than treated group (each p<0.05). In the DM-untreated group, TCA and LAs (p<0.05) and L/C ratio (p<0.01) were significantly lower in mNPDR subjects than normal controls (p<0.05). PDR in the DM-untreated group showed significantly larger SA and LA, and greater CCT than normal controls (each p<0.05). CONCLUSIONS: These results suggest that choroidal vasculature was initially involved at an early DR, whereas thickened LA and SA were noted in advanced DR.

Waardenburg症候群と網膜芽細胞腫を合併した13番染色体長腕部分欠失の1例　　　　　　　　　　　　　　　
赤岡 さくら, 安藤 亮, 加瀬 諭, 外木 秀文, 長 祐子, 藤井 史彦, 太田 亨, 石田 晋
日本眼科学会雑誌, 124, 臨増, 231, 231, (公財)日本眼科学会, 2020年03月
日本語

Supplemental Restraint Systemエアバッグによる網膜再剥離と気胸を発症した1例
新海 晃弘, 加瀬 諭, 山下 優, 森 祥平, 安藤 亮, 藤谷 顕雄, 鈴木 智浩, 野田 航介, 石田 晋
あたらしい眼科, 37, 2, 230, 234, (株)メディカル葵出版, 2020年02月
日本語

Increased choroidal blood flow and choroidal thickness in patients with hypertensive chorioretinopathy.
Michiyuki Saito, Kousuke Noda, Wataru Saito, Kiriko Hirooka, Yuki Hashimoto, Susumu Ishida
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 258, 2, 233, 240, 2020年02月, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: To investigate the alterations of central choroidal thickness (CCT) and macular choroidal blood flow in patients with hypertensive chorioretinopathy treated with antihypertensive agents. METHODS: In retrospective observational case series, ten eyes of 9 patients with hypertensive chorioretinopathy were enrolled (5 men and 4 women; 43.1 ± 19.6 years of age). CCT and mean blur rate (MBR) had been observed during follow-up using enhanced depth imaging optical coherence tomography and laser speckle flowgraphy, respectively. RESULTS: With the medication for hypertension, serous retinal detachment (SRD) disappeared in all the eyes (mean period, 57.8 ± 50.4 days), and the mean blood pressure decreased (122.7 ± 13.0 mmHg and 93.4 ± 13.2 mmHg at the initial visit and at the day of subretinal fluid absorption, respectively; P < 0.01). The mean logMAR value of best corrected visual acuity showed a tendency toward improvement with the resolution of SRD (0.15 ± 0.30 and 0.08 ± 0.28, P = 0.15). The average MBR significantly decreased when SRD was absorbed (11.4 ± 4.5 and 7.7 ± 2.2, P < 0.01). Similarly, the mean values of CCT decreased (473.2 ± 218.0 μm and 325.7 ± 112.0 μm, P < 0.01). The changing rates of CCT and MBR showed a significant positive correlation (P < 0.01, R = 0.88). CONCLUSION: The current study demonstrated a novel finding that choroidal blood flow velocity and thickness concurrently increased in the acute phase of hypertensive chorioretinopathy, suggesting the role of choroidal hyperperfusion in the pathogenesis of hypertensive chorioretinopathy.

Supplemental Restraint Systemエアバッグによる網膜再剥離と気胸を発症した1例　　　　　　　　　　　　　　　
新海 晃弘, 加瀬 諭, 山下 優, 森 祥平, 安藤 亮, 藤谷 顕雄, 鈴木 智浩, 野田 航介, 石田 晋
あたらしい眼科, 37, 2, 230, 234, (株)メディカル葵出版, 2020年02月, ［査読有り］
日本語

Three cases of intraocular foreign bodies removed through the anterior chamber　　　　　　　　　　　　　　　
Ayaka Hasegawa, Hiroshi Shimizu, Kousuke Noda, Kiriko Hirooka, Yukiko Shibata, Susumu Ishida
Japanese Journal of Clinical Ophthalmology, 74, 12, 1449, 1454, Igaku-Shoin Ltd, 2020年
日本語, 研究論文（学術雑誌）

A case of giant orbital conjunctival cyst mimicking lymphatic malformation
Yuka Suimon, Satoru Kase, Takako Ito, Susumu Ishida
European Journal of Ophthalmology, SAGE Publications Ltd, 2020年
英語, 研究論文（学術雑誌）

Pathological Role of Unsaturated Aldehyde Acrolein in Diabetic Retinopathy.
Miyuki Murata, Kousuke Noda, Susumu Ishida
Frontiers in immunology, 11, 589531, 589531, 2020年, ［国際誌］
英語, 研究論文（学術雑誌）, With increasing prevalence of diabetes and a progressively aging society, diabetic retinopathy is emerging as one of the global leading causes of blindness. Recent studies have shown that vascular endothelial growth factor (VEGF) plays a central role in the pathogenesis of diabetic retinopathy and anti-VEGF agents have become the first-line therapy for the vision-threatening disease. However, recent studies have also demonstrated that diabetic retinopathy is a multifactorial disease and that VEGF-independent mechanism(s) also underlie much of the pathological changes in diabetic retinopathy. Acrolein is a highly reactive unsaturated aldehyde and is implicated in protein dysfunction. As acrolein is common in air pollutants, previous studies have focused on it as an exogenous causative factor, for instance, in the development of respiratory diseases. However, it has been discovered that acrolein is also endogenously produced and induces cell toxicity and oxidative stress in the body. In addition, accumulating evidence suggests that acrolein and/or acrolein-conjugated proteins are associated with the molecular mechanisms in diabetic retinopathy. This review summarizes the pathological roles and mechanisms of endogenous acrolein production in the pathogenesis of diabetic retinopathy.

Cytoprotective Effect of Astaxanthin in a Model of Normal Intraocular Pressure Glaucoma.
Kasumi Kikuchi, Zhenyu Dong, Yasuhiro Shinmei, Miyuki Murata, Atsuhiro Kanda, Kosuke Noda, Takayuki Harada, Susumu Ishida
Journal of ophthalmology, 2020, 9539681, 9539681, 2020年, ［国際誌］
英語, 研究論文（学術雑誌）, Glaucoma is characterized by axonal degeneration of retinal ganglion cells (RGCs) and apoptotic death of their cell bodies. Lowering intraocular pressure is currently the only way to treat glaucoma, but it is often insufficient to inhibit the progression of the disease. Glaucoma is a multifactorial disease, and the involvement of oxidative stress has recently received much attention. In the present study, we investigated the cytoprotective effect of astaxanthin (AST) on RGC degeneration using a normal-tension glaucoma (NTG) mouse model, which lacks the glutamate/aspartate transporter (Glast) and demonstrates spontaneous RGC and optic nerve degeneration without elevated intraocular pressure. Three-week-old Glast± mice were given intraperitoneal injections of AST at 10, 30, or 60 mg/kg/day or vehicle alone, and littermate control mice were given vehicle alone for 14 days, respectively. Five weeks after birth, the number of RGCs was counted in paraffin sections of retinal tissues stained with hematoxylin and eosin. We also used a retrograde labeling technique to quantify the number of RGCs. Additionally, the phosphorylated (p) IκB/total IκB ratio and the 4-hydroxynonenal (HNE) were measured in retinal tissues. The number of RGCs in Glast± mice was significantly decreased compared with that in control mice. RGC loss was suppressed by the administration of AST at 60 mg/kg/day, compared with vehicle alone. Following AST administration, the concentration of 4-HNE in the retina was also suppressed, but the pIκB/IκB ratio did not change. Our study revealed that the antioxidative stress effects of AST inhibit RGC degeneration in the retina and may be useful in the treatment of NTG.

Relationship between diabetic macular edema and choroidal layer thickness.
Hiroaki Endo, Satoru Kase, Mitsuo Takahashi, Michiyuki Saito, Masahiko Yokoi, Chisato Sugawara, Satoshi Katsuta, Susumu Ishida, Manabu Kase
PloS one, 15, 1, e0226630, 2020年, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: To investigate the relationship between diabetic macular edema (DME) and the choroidal layer thickness in diabetic patients. METHODS: This is a retrospective observation study. Three hundred eighteen eyes of 159 diabetes mellitus (DM) patients and age-matched 100 eyes of 79 healthy controls were enrolled. DME was defined as over 300 μm in the central retinal subfield of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid sector. The central choroidal thickness (CCT), as well as inner and outer layers were determined based on enhanced depth imaging (EDI)-OCT. Diabetic patients with/without systemic diabetic treatments (DT) at the start of this study was defined as DT+ and DT-, respectively. The number of eyes examined was 62 and 256 eyes in DME+and DME-groups, respectively. DM patients were further subdivided into 4 groups with/without DME and DT; DME+DT+(35 eyes), DME-DT+(159 eyes), DME+DT-(27 eyes), and DME-DT-group (97 eyes). Multiple comparisons on CCT layers including control and each DM group were statistically examined. RESULTS: The total CCT layer was 254±83, 283±88, and 251±70 μm in the control, DME+, and DME-group, respectively. A total CCT layer in DME+was significantly thicker than the DME-group (P < 0.05). The outer CCT layer was 195±75, 222±83, and 193±63 μm in the control, DME+, and DME-group, respectively. The outer CCT layer in DME+ was significantly thicker than the DME-group (P < 0.05). In the subdivided groups, the total CCT layers in the control, DME+DT+, DME-DT+, DME+DT-and DME-DT-groups were 254±83, 274±88, 247±66, 290±84 and 258±75 μm, respectively. The outer CCT layers in each group were 195±75, 214±83, 189±58, 228±77, and 201±70 μm, respectively. Total CCT and the outer layer in DME+DT-was significantly thicker than the DME-DT+group (each P < 0.05). In contrast, there was no significant difference in inner layer between the groups. CONCLUSIONS: The total and outer CCT layers of diabetic eyes were significantly thickened in the DME+DT-as compared with the DME-DT+group, suggesting that CCT may be related to the pathology of DME.

Histological observation of trabecular meshwork in a patient with Axenfeld-Rieger syndrome-a new theory for the mechanism of ectropion uvea in congenital glaucoma.
Satoru Kase, Shinki Chin, Teruhiko Hamanaka, Yasuhiro Shinmei, Takeshi Ohguchi, Susumu Ishida
International journal of ophthalmology, 13, 7, 1167, 1169, 2020年, ［国際誌］
英語, 研究論文（学術雑誌）

Diabetic Cataract in Spontaneously Diabetic Torii Fatty Rats.
Kasumi Kikuchi, Miyuki Murata, Kousuke Noda, Satoru Kase, Yoshiaki Tagawa, Yasushi Kageyama, Masami Shinohara, Tomohiko Sasase, Susumu Ishida
Journal of diabetes research, 2020, 3058547, 3058547, 2020年, ［国際誌］
英語, 研究論文（学術雑誌）, Spontaneously Diabetic Torii (SDT) fatty rat is a novel animal model of type 2 diabetes with obesity. SDT fatty rats develop hyperglycemia, dyslipidemia, and other diabetic complications including ocular disorders; however, diabetic cataract formation in SDT fatty rats has not been fully investigated. The aim of the current study was to investigate the characteristics of cataract in the SDT fatty rats. The mean body weight of SDT fatty rats is larger than that of age-matched Sprague-Dawley (SD) rats and control animals until 8 weeks of age, and thereafter the growing speed decreased until the end of observation at 16 weeks of age. Blood glucose levels in SDT fatty rats were significantly higher than those in SD rats throughout the observational period. Slit-lamp examination revealed that no rats showed cataract formation at 5 weeks of age; however, SDT fatty rats gradually developed cortical cataract and posterior subcapsular cataract, both of which are the common types of cataract in patients with type 2 diabetes. The levels of glucose, sorbitol, and fructose were higher in the lens tissues of SDT fatty rats in comparison with that of SD rats. Furthermore, the level of 4-hydroxynonenal (4-HNE) was higher in the lens of SDT fatty rats than in that of SD rats. By contrast, total glutathione (GSH) concentration was lower in the lens of SDT fatty rats than in that of SD rats. The present study demonstrated that the cataractogenesis in SDT fatty rats resembled human diabetic cataract formation, indicating that SDT fatty rats serve as a potential animal model in researches on human cataract associated with type 2 diabetes and obesity.

Immunohistochemical and Immunocytochemical Analyses in Patients with Vitreoretinal Lymphoma.
Satoru Kase, Kenichi Namba, Hiromi Kanno-Okada, Masahiro Onozawa, Daisuke Hidaka, Daiju Iwata, Kazuomi Mizuuchi, Takako Fukuhara, Junichi Fukuhara, Nobuyoshi Kitaichi, Yoshihiro Matsuno, Susumu Ishida
Ocular immunology and inflammation, 28, 1, 147, 155, 2020年, ［査読有り］, ［国際誌］
英語, Purpose: The aim of this study was to analyze immunohistochemical and immunocytological findings by examining enucleated eyes and vitreous cell block (CB) in patients with vitreoretinal lymphoma (VRL).Methods: Histological specimens were obtained from two enucleated eyes with VRL associated with neovascular glaucoma. CB specimens were prepared in 18 patients from diluted waste fluids containing shredded vitreous. Histological and cytological specimens were submitted for hematoxylin-eosin staining and immunopathological analyses.Results: Both specimens demonstrated massive infiltration of large lymphoma cells. The lymphoma cells were positive for CD20 and MUM-1 in enucleated eyes. Membranous immunoreactivity for CD20 was observed in lymphoma cells in CB with VRL. Bcl-6 and MUM-1 were marked in five and eight out of nine cases examined, respectivelyConclusions: Cytological findings in CB specimens indicated similar histopathological characteristics of enucleated eyes. CB specimens obtained from vitreous waste diluted fluids may serve as effective materials for cytological diagnosis of VRL.

Improvements in visual acuity and macular morphology following cessation of anti-estrogen drugs in a patient with anti-estrogen maculopathy resembling macular telangiectasia type 2: A pathogenic hypothesis
Akihiro Shinkai, Wataru Saito, Yuki Hashimoto, Susumu Ishida
BMC Ophthalmology, 19, 1, BioMed Central Ltd., 2019年12月30日
英語, 研究論文（学術雑誌）

Sudden bilateral vision loss due to third ventricular cavernous angioma with intratumoral hemorrhage - case report.
Kan Ishijima, Yasuhiro Shinmei, Mayo Nozaki, Shigeru Yamaguchi, Shinki Chin, Susumu Ishida
BMC ophthalmology, 19, 1, 259, 259, 2019年12月16日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: We report a rare case of sudden bilateral vision loss due to third ventricular cavernous angioma with intratumoral hemorrhage. CASE PRESENTATION: A 45-year-old woman presented decreased visual acuity in both eyes. Her best corrected visual acuity was 0.1 in the right eye and 0.15 in the left eye. Goldmann perimetry showed bilateral central scotomas and bitemporal visual field defects. MRI demonstrated a lesion with mixed hypo- and hyperintensity at the optic chiasm, which was thought to be an intratumoral hemorrhage. The patient underwent bifrontal craniotomy. The tumor was exposed via an anterior interhemispheric approach, and histological evaluation of the mass led to a diagnosis of cavernous angioma. Six months after the surgery, her best corrected visual acuity was 0.9 in the right eye and 0.9 in the left, with slight bitemporal visual field defects. CONCLUSION: Third ventricular cavernous angioma is considered in the differential diagnosis of chiasmal syndrome. Contrast-enhanced MRI and FDG-PET might be useful for differential diagnosis of cavernous angioma from other chiasmal tumors including glioblastoma.

ポリープ状脈絡膜血管症に対する光線力学的療法トリプル療法の5年成績　　　　　　　　　　　　　　　
安藤 亮, 野田 航介, 廣岡 季里子, 柴田 有紀子, 橋本 勇希, 鈴木 智浩, 清水 啓史, 藤谷 顕雄, 董 震宇, 加瀬 諭, 吉澤 史子, 齋藤 航, 石田 晋
眼科臨床紀要, 12, 11, 832, 832, 眼科臨床紀要会, 2019年11月
日本語

網膜色素上皮細胞における胎盤成長因子のアポトーシス抑制効果　　　　　　　　　　　　　　　
村田 美幸, 野田 航介, 長谷 敬太郎, 神田 敦宏, 石田 晋
眼科臨床紀要, 12, 11, 850, 850, 眼科臨床紀要会, 2019年11月
日本語

網膜変性を認めたDanon病の1例　　　　　　　　　　　　　　　
長谷川 綾華, 藤谷 顕雄, 柴田 有紀子, 鈴木 智浩, 清水 啓史, 董 震宇, 加瀬 諭, 野田 航介, 石田 晋
眼科臨床紀要, 12, 11, 854, 854, 眼科臨床紀要会, 2019年11月
日本語

術後細菌性眼内炎との鑑別を要した水晶体起因性眼内炎の1例　　　　　　　　　　　　　　　
清水 啓史, 加瀬 諭, 柴田 有紀子, 鈴木 智浩, 董 震宇, 藤谷 顕雄, 野田 航介, 石田 晋
眼科臨床紀要, 12, 11, 856, 856, 眼科臨床紀要会, 2019年11月
日本語

妊娠後期に発症した中心性漿液性脈絡網膜症の1例における脈絡膜循環動態と形態の変化　　　　　　　　　　　　　　　
金子 悠菜, 橋本 勇希, 齋藤 理幸, 山下 結衣, 廣岡 季里子, 野田 航介, 石田 晋
日本視能矯正学会プログラム抄録集, 60回, 88, 88, 日本視能矯正学会, 2019年11月
日本語

妊娠に伴う高血圧脈絡膜症の1例における脈絡膜循環動態と形態の変化　　　　　　　　　　　　　　　
山下 結衣, 橋本 勇希, 齋藤 理幸, 金子 悠菜, 廣岡 季理子, 野田 航介, 石田 晋
日本視能矯正学会プログラム抄録集, 60回, 88, 88, 日本視能矯正学会, 2019年11月
日本語

Changes in Intraocular Pressure in Single Ventricle Patients After the Glenn or Fontan Procedure
Riki Kijima, Osamu Sasaki, Yasuhiro Shinmei, Takeshi Ohguchi, Atsuhito Takeda, Shinki Chin, Susumu Ishida
JOURNAL OF GLAUCOMA, 28, 11, 1012, 1014, 2019年11月, ［査読有り］
英語, 研究論文（学術雑誌）

黄斑部毛細血管拡張症type 2の視力と視細胞形態の推移　　　　　　　　　　　　　　　
新海 晃弘, 齋藤 航, 橋本 勇希, 齋藤 理幸, 野田 航介, 石田 晋
眼科臨床紀要, 12, 10, 791, 791, 眼科臨床紀要会, 2019年10月
日本語

Glucocorticoid receptor inhibits Müller glial galectin-1 expression via DUSP1-dependent and -independent deactivation of AP-1 signalling.
Ikuyo Hirose, Atsuhiro Kanda, Kousuke Noda, Susumu Ishida
Journal of cellular and molecular medicine, 23, 10, 6785, 6796, 2019年10月, ［国際誌］
英語, 研究論文（学術雑誌）, Galectin-1/LGALS1 is a hypoxia-induced angiogenic factor associated with diabetic retinopathy (DR). Recently, we elucidated a hypoxia-independent pathway to produce galectin-1 in Müller glial cells stimulated by interleukin (IL)-1β. Here we revealed glucocorticoid receptor (GR)-mediated inhibitory mechanisms for Müller glial galectin-1/LGALS1 expression. Activator protein (AP)-1 site in the LGALS1 enhancer region, to which activating transcription factor2, c-Fos and c-Jun bind, was shown to be essential for IL-1β-induced galectin-1/LGALS1 expression in Müller cells. Ligand (dexamethasone or triamcinolone acetonide)-activated GR induced dual specificity phosphatase (DUSP)1 expression via the glucocorticoid response element and attenuated IL-1β-induced galectin-1/LGALS1 expression by reducing phosphorylation of these AP-1 subunits following AKT and extracellular signal-regulated kinase (ERK)1/2 deactivation. Moreover, activated GR also caused DUSP1-independent down-regulation of IL-1β-induced LGALS1 expression via its binding to AP-1. Administration of glucocorticoids to mice attenuated diabetes-induced retinal galectin-1/Lgals1 expression together with AKT/AP-1 and ERK/AP-1 pathways. Supporting these in vitro and in vivo findings, immunofluorescence analyses showed co-localization of galectin-1 with GR and phosphorylated AP-1 in DUSP1-positive glial cells in fibrovascular tissues from patients with DR. Our present data demonstrated the inhibitory effects of glucocorticoids on glial galectin-1 expression via DUSP1-dependent and -independent deactivation of AP-1 signalling (transactivation and transrepression), highlighting therapeutic implications for DR.

Unsaturated Aldehyde Acrolein Promotes Retinal Glial Cell Migration.
Miyuki Murata, Kousuke Noda, Shiho Yoshida, Michiyuki Saito, Akio Fujiya, Atsuhiro Kanda, Susumu Ishida
Investigative ophthalmology & visual science, 60, 13, 4425, 4435, 2019年10月01日, ［国際誌］
英語, 研究論文（学術雑誌）, Purpose: To investigate the effect of the unsaturated aldehyde acrolein on retinal glial cell migration. Methods: Müller glial cell markers expression in TR-MUL5 were confirmed by RT-PCR and immunostaining. Cell viability and migration rate of TR-MUL5 cells were assessed after the stimulation with acrolein. DNA microarray analysis was performed to analyze changes in the expression levels of migration-related genes in Müller glial cells stimulated with acrolein. Real-time PCR and ELISA were performed to validate DNA microarray analysis results. Inhibitors of C-X-C motif chemokine ligand 1 (CXCL1), one of the genes highly upregulated after the exposure to acrolein, and blockers of its receptor, CXCR2, were used to investigate the role of the CXCL1-CXCR2 axis on glial cell migration. CXCL1 concentration was measured in vitreous fluid samples obtained from proliferative diabetic retinopathy (PDR) and nondiabetic control eyes. CXCL1 and CXCR2 expression in glial cells of fibrovascular tissues obtained from PDR patients was examined by immunostaining. Results: At a high concentration, acrolein (100 μM) significantly decreased cell viability. However, in moderate, sublethal concentrations (25-50 μM), acrolein induced cell migration and substantially increased the production of CXCL1 in TR-MUL5 cells. CXCL1 concentration was significantly elevated in vitreous fluids of PDR patients, and CXCL1 and CXCR2 were present in glial cells in fibrovascular tissues of PDR patients. CXCL1 stimulation increased glial cell migration in a dose-dependent manner, which was abrogated by the neutralization of the CXCL1-CXCR2 axis. Conclusions: Our data demonstrate that acrolein promotes retinal Müller glial cell migration by enhancing CXCL1 production.

Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor.
Ye Liu, Atsuhiro Kanda, Di Wu, Erdal Tan Ishizuka, Satoru Kase, Kousuke Noda, Atsuhiro Ichihara, Susumu Ishida
Molecular therapy. Nucleic acids, 17, 113, 125, 2019年09月06日, ［国際誌］
英語, 研究論文（学術雑誌）, The receptor-associated prorenin system refers to the pathogenic mechanism whereby prorenin binding to (pro)renin receptor [ (P)RR] dually activates the tissue renin-angiotensin system (RAS) and RAS-independent signaling, and its activation contributes to the molecular pathogenesis of various ocular diseases. We recently developed a new single-stranded RNAi agent targeting both human and mouse (P)RR ((P)RR-proline-modified short hairpin RNA [ (P)RR-PshRNA]), and confirmed its therapeutic effect on murine models of ocular inflammation. Here, we investigated the efficacy of (P)RR-PshRNA against laser-induced choroidal neovascularization (CNV) and subretinal fibrosis, both of which are involved in the pathogenesis of age-related macular degeneration (AMD). Administration of (P)RR-PshRNA in mice significantly reduced CNV formation, together with the expression of inflammatory molecules, macrophage infiltration, and extracellular signal-regulated kinase (ERK) 1/2 activation. In addition, (P)RR-PshRNA attenuated subretinal fibrosis, together with epithelial-mesenchymal transition (EMT)-related markers including phosphorylated SMAD2. The suppressive effect of (P)RR-PshRNA is comparable with aflibercept, an anti-vascular endothelial growth factor drug widely used for AMD therapy. AMD patient specimens demonstrated (P)RR co-localization with phosphorylated ERK1/2 in neovascular endothelial cells and retinal pigment epithelial cells. These results indicate that (P)RR contributes to the ocular pathogenesis of both inflammation-related angiogenesis and EMT-driven fibrosis, and that (P)RR-PshRNA is a promising therapeutic agent for AMD.

Adenosquamous Carcinoma Arising in Bulbar Conjunctiva
Satoru Kase, Susumu Ishida
Ophthalmic plastic and reconstructive surgery, 35, 5, e109, e110, NLM (Medline), 2019年09月01日
英語, 研究論文（学術雑誌）

網膜上下の増殖組織が連続していた黄斑円孔網膜剥離併発の増殖糖尿病網膜症の1例　　　　　　　　　　　　　　　
柴田 有紀子, 清水 啓史, 長谷川 綾華, 品川 真有子, 齋藤 理幸, 加瀬 諭, 野田 航介, 石田 晋
糖尿病合併症, 33, Suppl.1, 266, 266, (一社)日本糖尿病合併症学会, 2019年09月
日本語

Spontaneously Diabetic Torii fattyラット網膜における炎症性サイトカインの発現解析　　　　　　　　　　　　　　　
菊地 香澄, 野田 航介, 村田 美幸, 神田 敦宏, 加瀬 諭, 影山 靖, 篠原 雅巳, 笹瀬 智彦, 石田 晋
糖尿病合併症, 33, Suppl.1, 271, 271, (一社)日本糖尿病合併症学会, 2019年09月
日本語

網膜色素上皮細胞における胎盤成長因子による血管内皮増殖因子受容体 2の安定化機序　　　　　　　　　　　　　　　
村田 美幸, 野田 航介, 長谷 敬太郎, Di Wu, 神田 敦宏, 石田 晋
糖尿病合併症, 33, Suppl.1, 271, 271, (一社)日本糖尿病合併症学会, 2019年09月
日本語

Comparison of clinical characteristics in patients with Vogt-Koyanagi-Harada disease with and without anti-retinal antibodies.
Yuki Hashimoto, Wataru Saito, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Kousuke Noda, Atsuhiro Kanda, Susumu Ishida
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 257, 8, 1751, 1758, 2019年08月, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: To compare the clinical characteristics of Vogt-Koyanagi-Harada (VKH) disease patients with and without anti-retinal antibodies (ARAs) that are frequently detected in autoimmune retinopathy. METHODS: Using immunoblot analyses, serum autoantibodies for recoverin, carbonic anhydrase II, and α-enolase were examined in 20 treatment-naïve patients with VKH disease. Clinical factors before and after systemic corticosteroid therapy, including best-corrected visual acuity (BCVA) and macular outer retinal morphology, were statistically compared between patients with VKH disease with and without ARAs. RESULTS: Serum ARAs were detected in 50.0% of patients with VKH disease. There were no significant differences in clinical factors between the two groups, including final BCVA, frequency of uveitis recurrence, and recovery of the macular ellipsoid zone after systemic corticosteroid therapy. CONCLUSIONS: Our results suggest that the detected ARAs did not influence visual outcomes, the chronicity of uveitis, or outer retinal morphology in patients with VKH disease.

抗α-enolase抗体陽性自己免疫性網膜症の網膜電図所見　　　　　　　　　　　　　　　
安藤 亮, 齋藤 航, 神田 敦宏, 加瀬 諭, 藤波 芳, 菅原 道孝, 中村 洋介, 江口 秀一郎, 野田 航介, 篠田 啓, 石田 晋
眼科臨床紀要, 12, 8, 642, 643, 眼科臨床紀要会, 2019年08月, ［査読有り］
日本語

Relationship between choroidal structure and duration of diabetes.
Hiroaki Endo, Satoru Kase, Yuki Ito, Mitsuo Takahashi, Masahiko Yokoi, Satoshi Katsuta, Shozo Sonoda, Taiji Sakamoto, Susumu Ishida, Manabu Kase
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 257, 6, 1133, 1140, 2019年06月, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: The aim of this study was to evaluate the relationship between the choroidal structure of diabetic patients without diabetic retinopathy (DR) and duration of diabetes. METHODS: This study is a retrospective observational study in diabetic patients without DR. Eyes with diabetes mellitus (DM) (n = 105) were divided into two groups based on the duration: long duration group (over 10 years, n = 31) and short duration group (less than 10 years, n = 74). One hundred seventeen eyes of non-diabetic patients were used as control group. All patients underwent enhanced depth imaging optical coherence tomography, and the choroidal structure was analyzed using a binarization method. RESULTS: There was no significant difference in areas of total choroid and lumina/stroma or central choroidal thickness (CCT) between control and DM groups. In contrast, lumina/total choroidal (L/C) ratio was significantly lower in diabetic eyes than in control eyes (P = 0.02). Although there was no significant difference in the areas or CCT between short and long duration groups, L/C ratio was significantly lower in the long duration group than in the short duration group (P = 0.03). CONCLUSIONS: The current study suggests that choroidal vasculature is involved in the diabetic eyes and that the choroidal structure has changed with duration of diabetes. Our study points out that L/C ratio is a new potential biomarker in monitoring choroidal vascular disorders in diabetic eyes without DR.

Cyclosporine and prednisolone combination therapy as a potential therapeutic strategy for relentless placoid chorioretinitis.
Takehiko Uraki, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Shigeaki Ohno, Nobuyoshi Kitaichi, Susumu Ishida
American journal of ophthalmology case reports, 14, 87, 91, 2019年06月, ［査読有り］, ［国際誌］
英語, Purpose: Relentless placoid chorioretinitis (RPC) is a new disease concept that was proposed by Jones et al. in 2000. Some cases of RPC have been reported; however, a treatment strategy has not yet been established. We report herein four cases of patients diagnosed with RPC. Observations: We experienced four cases of RPC in patients aged 24-51 years. All patients exhibited retinal lesions similar to that seen in acute posterior multifocal placoid pigment epitheliopathy or serpiginous choroiditis from the posterior pole to the surrounding region. Although patients underwent systemic prednisolone (PSL) therapy, recurrence was observed and the retinal scar formation was progressive; they were then diagnosed with RPC. In all cases, cyclosporine (CyA) was administered in addition to PSL, no recurrence was observed thereafter. Conclusions and Importance: RPC is a rare disease, and a treatment strategy has not yet been established. CyA and PSL combination therapy is considered to be effective in the treatment of RPC.

Increased thickness and decreased blood flow velocity of the choroid in a patient with acute macular neuroretinopathy
Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Yuka Hasegawa, Susumu Ishida
BMC Ophthalmology, 19, 1, BioMed Central Ltd., 2019年05月14日
英語, 研究論文（学術雑誌）

Photocoagulation for juxtapapillary retinal hemangioma in a young girl: A case report.
Satoru Kase, Susumu Ishida
Molecular and clinical oncology, 10, 5, 521, 523, 2019年05月, ［国際誌］
英語, 研究論文（学術雑誌）, von Hippel Lindau (VHL) disease is caused by inactivation of the VHL tumor suppressor gene, resulting in formation of multiple systemic tumors. Juxtapapillary retinal capillary hemangioma (JRCH) is one of the major manifestations in VHL disease; however, treatments are challenging, especially in children. The present study reports the case of a 6-year-old girl with suspected VHL disease presenting with JRCH. Fluorescein angiography demonstrated marked dye leakage from the tumor. Retinal hemorrhage occurred around the tumor 7 months later. Laser photocoagulation of the tumor tissue was safely and successfully conducted without general anesthesia. The hemorrhage diminished after laser photocoagulation. Optical coherence tomography demonstrated mild resolution of an elevated lesion in JRCH with contraction of the vitreoretinal interface over the tumor. Laser photocoagulation may be considered the first-line treatment for young patients with JRCH, although the primary physicians must have the necessary skills and be able to establish good doctor-patient relationships, even with children.

Involvement of circulatory disturbance in optic disk melanocytoma with visual dysfunction.
Iku Kikuchi, Satoru Kase, Yuki Hashimoto, Kiriko Hirooka, Susumu Ishida
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 257, 4, 835, 841, 2019年04月, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: This study aims to examine the relationship between ocular circulation changes and visual field defects in optic disk melanocytoma (ODM). METHODS: Five eyes of five patients were enrolled in this study. All patients were diagnosed with ODM in the Department of Ophthalmology, Hokkaido University Hospital from March 2009 to November 2017. Ophthalmological data including optical coherence tomography angiography (OCTA) and laser speckle flowgraphy (LSFG) findings were retrospectively analyzed. RESULTS: The five ODM cases consisted of two females and three males. Ages of the patients ranged from 47 to 82 years (mean 54 years). Follow-up periods were from 4 to 105 months. Fluorescein angiography showed hypo-fluorescence throughout the examination in all four eyes examined with this modality. OCTA detected dense blood vessel networks in the tumor in two out of the five eyes. Nasal visual field defects were found in two other eyes, which were correlated with locations of tumors free of vessel networks. One ODM eye without marked visual field defects and pigmentations showed lower mean blur rates determined by LSFG in optic disk vessels and tissue circulations than those in the contralateral eye. During follow-up, there was no tumor enlargement in any case. CONCLUSIONS: This study showed the relationship between the deficit of blood vessel networks and visual field defects in ODM patients. LSFG demonstrated reduced blood flow in the tumor, suggesting that circulatory disorder caused by the optic disk tumor might be correlated with visual field defect.

機能的単心室症におけるグレン手術およびフォンタン手術前後の眼圧の変化　　　　　　　　　　　　　　　
木嶋 理紀, 佐々木 理, 新明 康弘, 大口 剛司, 武田 充人, 陳 進輝, 石田 晋
日本眼科学会雑誌, 123, 臨増, 158, 158, (公財)日本眼科学会, 2019年03月
日本語

人工多能性幹細胞由来マクロファージ様免疫抑制細胞を用いたぶどう膜炎モデルの軽症化　　　　　　　　　　　　　　　
長谷 敬太郎, 南場 研一, 北市 伸義, 岩田 大樹, 辻 飛雄馬, 和田 はるか, 清野 研一郎, 石田 晋
日本眼科学会雑誌, 123, 臨増, 226, 226, (公財)日本眼科学会, 2019年03月
日本語

Spontaneously Diabetic Torii fattyラットにおける糖尿病白内障の検討　　　　　　　　　　　　　　　
菊地 香澄, 野田 航介, 村田 美幸, 田川 義晃, 神田 敦宏, 加瀬 諭, 影山 靖, 篠原 雅巳, 笹瀬 智彦, 石田 晋
日本眼科学会雑誌, 123, 臨増, 166, 166, (公財)日本眼科学会, 2019年03月
日本語

トレミフェン内服中止後に視機能が改善した黄斑部毛細血管拡張症type 2の1例　　　　　　　　　　　　　　　
新海 晃弘, 齋藤 航, 橋本 勇希, 野田 航介, 石田 晋
日本眼科学会雑誌, 123, 臨増, 289, 289, (公財)日本眼科学会, 2019年03月
日本語

Galectin-1 promotes choroidal neovascularization and subretinal fibrosis mediated via epithelial-mesenchymal transition
Di W, Kanda A, Ye L, Kase S, Noda, K, Ishida S
FASEB J, 33, 2, 2498, 2513, 2019年02月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, VEGFA and TGF-β are known major angiogenic and fibrogenic factors. Galectin-1, encoded by lectin, galactoside-binding, soluble ( LGALS) 1, has attracted growing attention for its facilitatory role in angiogenesis and fibrosis through its modification of VEGFA and TGF-β receptor signaling pathways. We reveal galectin-1 involvement in the mouse model of laser-induced choroidal neovascularization (CNV) and subretinal fibrosis, both of which represent the pathogenesis of age-related macular degeneration (AMD). Neither deletion nor overexpression of Lgals1 affected physiologic retinal development or visual function. Galectin-1/ Lgals1 was upregulated by CNV induction, whereas deletion of Lgals1 suppressed CNV together with downstream molecules of VEGF receptor (VEGFR)2. Loss of Lgals1 also attenuated subretinal fibrosis, expression of epithelial-mesenchymal transition (EMT) markers including Snai1, and phosphorylation of SMAD family member 2. Supporting these in vivo findings, silencing of LGALS1 in human retinal pigment epithelial (RPE) cells inhibited TGF-β1-induced EMT-related molecules and cell motilities. Conversely, overexpression of Lgals1 enhanced CNV and subretinal fibrosis. Specimens from patients with AMD demonstrated colocalization of galectin-1 with VEGFR2 in neovascular endothelial cells and with phosphorylated SMAD2 in RPE cells. These results suggested a biologic significance of galectin-1 as a key promotor for both angiogenesis and fibrosis in eyes with AMD.-Wu, D., Kanda, A., Liu, Y., Kase, S., Noda, K., Ishida, S. Galectin-1 promotes choroidal neovascularization and subretinal fibrosis mediated via epithelial-mesenchymal transition.

TGF-β-SNAIL axis induces Müller glial-mesenchymal transition in the pathogenesis of idiopathic epiretinal membrane.
Atsuhiro Kanda, Kousuke Noda, Ikuyo Hirose, Susumu Ishida
Scientific reports, 9, 1, 673, 673, 2019年01月24日, ［国際誌］
英語, 研究論文（学術雑誌）, The epithelial-mesenchymal transition (EMT) is a key process in fibrogenic diseases where transdifferentiated myofibroblasts produce excessive amounts of extracellular matrix, resulting in organ dysfunction. Idiopathic epiretinal membrane (iERM) is a vision-threatening disorder characterized by fibrocellular proliferation and contraction on the central retina. Müller glial cells, which regulate retinal physiology and structure, are the major cellular components in the iERM tissue; however, the pathological role of this cell type remains incompletely understood. Here we revealed the involvement of Müller glial-mesenchymal transition (GMT), as an alternative to EMT, in the pathogenesis of iERM lacking epithelial contribution in nature. Of various pro-fibrotic cytokines, transforming growth factor (TGF)-β1 stimulation to human Müller glial cells exclusively increased mRNA and protein levels of several EMT-related molecular markers, together with the transcription factor SNAIL but not SLUG or TWIST. TGF-β1-stimulated Müller cells also exhibited EMT-related cell motility, while reducing the expression of glutamine synthetase (GS), a Müller glial marker. Notably, all of these TGF-β-induced EMT features were reversed by SNAI1 knockdown in Müller cells. iERM patient specimens demonstrated co-immunolocalization of SNAIL with TGF-β1, GS, and smooth muscle protein 22. Our data implicated a critical role of the TGF-β-SNAIL axis in Müller GMT to promote iERM formation.

Corneal hyperalgesia in patients with short tear film break-up time dry eye.
Yoshiaki Tagawa, Kousuke Noda, Takeshi Ohguchi, Yoshitsugu Tagawa, Susumu Ishida, Nobuyoshi Kitaichi
The ocular surface, 17, 1, 55, 59, 2019年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: To evaluate corneal tactile and pain sensations in patients with short tear film break-up time dry eye (sBUT DE). METHODS: This study enrolled 60 patients with sBUT DE and 46 healthy volunteers from Japan. We evaluated corneal tactile and pain sensations using a modified method with the Cochet-Bonnet corneal esthesiometer. RESULTS: Patients with sBUT DE had higher corneal pain sensitivity (26.3 ± 23.1 mm) than healthy subjects (6.9 ± 16.4 mm), but similar corneal tactile sensation (52.0 ± 15.5 mm and 52.9 ± 14.9 mm, respectively). In patients with sBUT DE and corneal hyperalgesia (n = 22, 36.7%), defined as a pain sensitivity ≥40 mm (i.e., the cutoff value at the 95th percentile of corneal pain sensitivity in healthy subjects), a strong significant correlation was found between the subjective pain score and objective corneal pain sensation (R = 0.79). However, for the entire cohort, we found a weak positive correlation between the subjective pain score and objective corneal pain sensation. CONCLUSIONS: Patients with sBUT DE were hypersensitive to corneal pain, which suggested that corneal hyperalgesia partly accounted for subjective symptoms in patients with sBUT DE.

Usefulness of topical interferon alpha-2b eye drop as an adjunctive therapy following surgical resection in ocular surface squamous neoplasia
Rina Kanaya, Satoru Kase, Kan Ishijima, Susumu Ishida
In Vivo, 33, 6, 2211, 2215, International Institute of Anticancer Research, 2019年
英語, 研究論文（学術雑誌）

Clinicopathological features of cystic lesions in the eyelid
Yuka Suimon, Satoru Kase, Kan Ishijima, Hiromi Kanno-Okada, Susumu Ishida
Biomedical Reports, 10, 2, 92, 96, Spandidos Publications, 2019年
英語, 研究論文（学術雑誌）

Increased plasma galectin-1 correlates with advanced glycation end products and interleukin-1β in patients with proliferative diabetic retinopathy.
Keitaro Hase, Atsuhiro Kanda, Kousuke Noda, Susumu Ishida
International journal of ophthalmology, 12, 4, 692, 694, 2019年, ［国際誌］
英語, 研究論文（学術雑誌）

Involvement of Inner Choroidal Layer in Choroidal Thinning during Regression of Multiple Evanescent White Dot Syndrome.
Yuki Hashimoto, Wataru Saito, Yuka Hasegawa, Kousuke Noda, Susumu Ishida
Journal of ophthalmology, 2019, 6816925, 6816925, 2019年, ［国際誌］
英語, 研究論文（学術雑誌）, Purpose: To investigate relationships between total thickness and the thickness of inner and outer layers in the choroid during regression in patients with multiple evanescent white dot syndrome (MEWDS). Methods: This retrospective observational case series included 15 unilaterally affected eyes and 13 unaffected fellow eyes from 15 MEWDS patients (4 men and 11 women; mean age, 37.6 ± 17.6 years). Using enhanced depth imaging optical coherence tomography, whole, inner, and outer choroidal layer thicknesses at the fovea and perifovea were manually measured at the initial visit and at 1 and 3 months after the initial visit. The mean thickness values of the layers were compared at each stage. Results: With regression of MEWDS, the mean subfoveal whole and inner choroidal layer thicknesses significantly decreased at 1 and 3 months compared to baseline values in MEWDS eyes (P=0.01 and P < 0.0001, respectively), but not in fellow eyes. The outer layer in MEWDS eyes tended to thin. Changes in the inner and outer layers at the perifovea in MEWDS eyes also showed the same trends. Simple linear regression analysis revealed significant positive correlations in choroidal thickness changes between the whole and inner layers (R = 0.53, P=0.04) and between the whole and outer layers (R = 0.91, P < 0.0001) from baseline to 3 months. Multiple linear regression analysis revealed that choroidal thickness changes in the whole layer were significantly correlated with those in the inner (β = 0.51, P < 0.0001) and outer (β = 0.73, P < 0.0001) layers. Conclusion: The inner choroidal layer significantly thinned with regression of MEWDS, correlating with the thinning of total choroidal thickness. These results suggest that MEWDS lesions in the choroid are likely to lie mainly in the inner layer.

A case of nodular posterior scleritis simulating intraocular tumor.
Yukiko Shibata, Satoru Kase, Kenichi Namba, Susumu Ishida
International journal of ophthalmology, 12, 4, 685, 688, 2019年, ［国際誌］
英語, 研究論文（学術雑誌）

Rhegmatogenous retinal detachment in a patient with choroidal melanoma simulating choroidal detachment: A case report
Satoru Kase, Yuka Suimon, Kan Ishijima, Susumu Ishida
Journal of Medical Case Reports, 12, 1, BioMed Central, 2018年12月25日
英語, 研究論文（学術雑誌）

Changes in blood flow velocity and thickness of the choroid in a patient with leukemic retinopathy.
Takita A, Hashimoto Y, Saito W, Kase S, Ishida S
American journal of ophthalmology case reports, 12, 68, 72, 2018年12月, ［査読有り］

Acute macular neuroretinopathyにおける脈絡膜層別厚の経時変化　　　　　　　　　　　　　　　
橋本 勇希, 齋藤 航, 滝田 亜かり, 長谷川 裕香, 鈴木 智浩, 安藤 亮, 藤谷 顕雄, 森 祥平, 加瀬 諭, 野田 航介, 石田 晋
眼科臨床紀要, 11, 11, 836, 837, 眼科臨床紀要会, 2018年11月
日本語

MPO-ANCA陽性を示したparacentral acute middle maculopathyの1例　　　　　　　　　　　　　　　
福津 佳苗, 安藤 亮, 新明 康弘, 鈴木 智浩, 藤谷 顕雄, 森 祥平, 加瀬 諭, 阿部 早和子, 齋藤 航, 野田 航介, 石田 晋
眼科臨床紀要, 11, 11, 837, 837, 眼科臨床紀要会, 2018年11月
日本語

エアバッグによる網膜再剥離と気胸を発症した1例　　　　　　　　　　　　　　　
新海 晃弘, 加瀬 諭, 森 祥平, 安藤 亮, 藤谷 顕雄, 鈴木 智浩, 野田 航介, 石田 晋
眼科臨床紀要, 11, 11, 846, 846, 眼科臨床紀要会, 2018年11月
日本語

血管径自動解析プログラムによる網膜動静脈比と血圧脈波の相関　　　　　　　　　　　　　　　
齋藤 理幸, 野田 航介, 星川 靖裕, 小林 正彦, 道家 充, 村田 美幸, 齋藤 航, 加瀬 学, 石田 晋
眼科臨床紀要, 11, 11, 850, 851, 眼科臨床紀要会, 2018年11月
日本語

Clinical features of Japanese patients with anti-α-enolase antibody-positive autoimmune retinopathy: Novel subtype of multiple drusen.
Ando R, Saito W, Kanda A, Kase S, Fujinami K, Sugahara M, Nakamura Y, Eguchi S, Mori S, Noda K, Shinoda K, Ishida S
American journal of ophthalmology, 196, 181, 196, 2018年09月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: To evaluate clinical features of Japanese patients with anti-α-enolase antibody-positive autoimmune retinopathy (anti-enolase AIR). DESIGN: Multicenter retrospective observational case series. METHODS: Forty-nine eyes of 25 Japanese anti-enolase AIR patients (16 female and 9 male; mean age at first visit, 60.8 years) were included. Fundus characteristics, perimetry, spectral-domain optical coherence tomography (SD-OCT), electroretinography (ERG), best-corrected visual acuity (BCVA), and complicating systemic tumors were assessed. Protein localization of α-enolase was examined by immunohistochemistry in an enucleated eye of 1 patient. RESULTS: Patients were classified into 3 groups: multiple drusen (48%), retinal degeneration (36%), and normal fundus (16%). Drusen varied in size from small deposits to vitelliform-like lesions. Images on SD-OCT revealed dome-shaped hyperreflectivity beneath the retinal pigment epithelium (RPE), corresponding to drusen. Perimetry showed that ring scotoma was the most frequent (39%). Rod-system and/or single-flash cone responses revealed decreased responses in 81% of the eyes. Combined rod and cone system responses demonstrated significantly lower a-wave amplitudes in the degeneration group than in the drusen group (P = .005). BCVA was improved or maintained in 80% of the eyes during follow-up. Malignant or benign tumors were detected in 30% of patients. The RPE and photoreceptor layers were immunopositive for α-enolase. CONCLUSIONS: The drusen subtype, scarcely described in the literature, is suggested to characterize Japanese patients with anti-enolase AIR. The different funduscopic features with different functional severities may have resulted from antibody-mediated damage to RPE as well as photoreceptor cells.

糖尿病網膜症における血管新生因子ガレクチン-1による病態形成への関与　　　　　　　　　　　　　　　
石田 晋, 董 陽子, 野田 航介, 齋藤 航, 神田 敦宏
日本糖尿病眼学会誌, 22, 132, 132, 日本糖尿病眼学会, 2018年09月
日本語

糖尿病網膜症におけるポリアミン代謝の病態関与　　　　　　　　　　　　　　　
野田 航介, 村田 美幸, 神田 敦宏, 石田 晋
日本糖尿病眼学会誌, 22, 132, 132, 日本糖尿病眼学会, 2018年09月
日本語

糖尿病網膜症の増殖組織における分子シャペロンαB-クリスタリンのリン酸化　　　　　　　　　　　　　　　
加瀬 諭, 董 陽子, 神田 敦宏, 野田 航介, 石田 晋
日本糖尿病眼学会誌, 22, 133, 133, 日本糖尿病眼学会, 2018年09月
日本語

視機能と網膜機能が良好であった中心窩温存黄色斑眼底の1例　　　　　　　　　　　　　　　
新海 晃弘, 齋藤 航, 廣岡 季里子, 藤波 芳, 篠田 啓, 野田 航介, 石田 晋
眼科臨床紀要, 11, 7, 552, 552, 眼科臨床紀要会, 2018年07月
日本語

Two cases of cytomegalovirus panuveitis in immunocompetent patients
Masato Sakai, Hiroshi Takase, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Susumu Ishida
American Journal of Ophthalmology Case Reports, 10, 189, 191, Elsevier Inc, 2018年06月01日, ［査読有り］
英語, 研究論文（学術雑誌）

The clinical features of radiation cataract in patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma
Kanae Fukutsu, Satoru Kase, Kan Ishijima, Rumiko Kinoshita, Susumu Ishida
Radiation Oncology, 13, 1, 95, BioMed Central Ltd., 2018年05月16日, ［査読有り］
英語, 研究論文（学術雑誌）

Proteolytic cleavage of vascular adhesion protein-1 induced by vascular endothelial growth factor in retinal capillary endothelial cells
Shiho Yoshida, Miyuki Murata, Kousuke Noda, Takashi Matsuda, Michiyuki Saito, Wataru Saito, Atsuhiro Kanda, Susumu Ishida
Japanese Journal of Ophthalmology, 62, 2, 256, 264, Springer Tokyo, 2018年03月01日, ［査読有り］
英語, 研究論文（学術雑誌）

(Pro)renin receptor: Involvement in diabetic retinopathy and development of molecular targeted therapy.
Kanda A, Ishida S
Journal of diabetes investigation, 2018年03月, ［査読有り］

CHOROIDAL THICKNESS CHANGES IN A PATIENT DIAGNOSED WITH CENTRAL SEROUS CHORIORETINOPATHY DURING FOLLOW-UP FOR PACHYCHOROID PIGMENT EPITHELIOPATHY.
Saito W, Hashimoto Y, Hirooka K, Ishida S
Retinal cases & brief reports, 2018年02月, ［査読有り］

Relationship between choroidal blood flow velocity and choroidal thickness in patients with regression of acute central serous chorioretinopathy
Michiyuki Saito, Kousuke Noda, Wataru Saito, Susumu Ishida
Graefe's Archive for Clinical and Experimental Ophthalmology, 256, 1, 227, 229, Springer Verlag, 2018年01月01日, ［査読有り］
英語

Anterior proliferative vitreoretinopathy in a patient with Coats disease
Satoru Kase, Shohei Mori, Kousuke Noda, Susumu Ishida
International Journal of Ophthalmology, 11, 2, 343, 345, International Journal of Ophthalmology (c/o Editorial Office), 2018年, ［査読有り］
英語

Role of the Epipapillary Membrane in Maculopathy Associated with Cavitary Optic Disc Anomalies: Morphology, Surgical Outcomes, and Histopathology.
Tanaka A, Saito W, Kase S, Ishijima K, Noda K, Ishida S
Journal of ophthalmology, 2018, 5680503, 5680503, 2018年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Purpose: To evaluate the surgical outcomes of pars plana vitrectomy (PPV) with epipapillary membrane removal in patients with maculopathy associated with cavitary optic disc anomalies. Methods: Eight patients (8 eyes) with cavitary optic disc anomaly-associated maculopathy who underwent PPV with epipapillary membrane removal were retrospectively reviewed. The best-corrected visual acuity (BCVA) and macular and papillary morphologies using enhanced depth imaging optical coherence tomography (EDI-OCT) were evaluated before and after treatment. Immunohistochemistry for an intraoperatively excised epipapillary membrane tissue was also performed. Results: Before surgery, EDI-OCT revealed that epipapillary membrane was observed in all patients. Retinoschisis was resolved with no recurrence in all patients following vitrectomy regardless of a disease type or the presence or absence of preoperative posterior vitreous detachment. The mean final BCVA and central retinal thickness significantly improved compared with pretreatment values (P = 0.008 and 0.004, resp.). Immunoreactivity for S100 protein and glial fibrillary acidic protein, markers of astrocytes, was positive in the resected membrane tissues. Conclusions: These results suggest that epipapillary membrane is involved in the pathogenesis of some patients with cavitary optic disc anomaly-associated maculopathy as well as posterior hyaloid membrane. PPV with epipapillary membrane removal may be a useful treatment option for this maculopathy. This trial is registered with UMIN000011123.

Expression of VEGF in human conjunctival melanoma analyzed with immunohistochemistry
Satoru Kase, Iku Kikuchi, Susumu Ishida
Clinical Ophthalmology, 12, 2363, 2367, Dove Medical Press Ltd, 2018年
英語, 研究論文（学術雑誌）

A clinicopathological study on IgG4-related ophthalmic disease.
Suimon Y, Kase S, Ishijima K, Kanno-Okada H, Ishida S
International journal of ophthalmology, 11, 9, 1539, 1544, 2018年, ［査読有り］

Soluble Vascular Adhesion Protein-1 Mediates Spermine Oxidation as Semicarbazide-Sensitive Amine Oxidase: Possible Role in Proliferative Diabetic Retinopathy
Miyuki Murata, Kousuke Noda, Akiko Kawasaki, Shiho Yoshida, Yoko Dong, Michiyuki Saito, Zhenyu Dong, Ryo Ando, Shohei Mori, Wataru Saito, Atsuhiro Kanda, Susumu Ishida
Current Eye Research, 42, 12, 1674, 1683, Taylor and Francis Ltd, 2017年12月02日, ［査読有り］
英語, 研究論文（学術雑誌）

Usefulness of PET/CT for early detection of internal malignancies in patients with Muir-Torre syndrome: report of two cases.
Yui Ishiguro, Shigenori Homma, Tadashi Yoshida, Yosuke Ohno, Nobuki Ichikawa, Hideki Kawamura, Hiroo Hata, Satoru Kase, Susumu Ishida, Hiromi Okada-Kanno, Kanako C Hatanaka, Akinobu Taketomi
Surgical case reports, 3, 1, 71, 71, 2017年12月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Muir-Torre syndrome (MTS) is a rare autosomal dominant genodermatosis caused by mutations in mismatch repair genes. It is characterized by the presence of at least one sebaceous skin tumor associated with internal malignancies. Whether positron emission tomography/computed tomography (PET/CT) is useful for the detection of malignancies in patients with MTS has not been determined. We herein report two cases in which PET/CT was useful for the diagnosis and follow-up of internal malignancies in patients with MTS. CASE PRESENTATION: In case 1, a 57-year-old woman underwent excision of a sebaceous carcinoma on the left upper eyelid. She underwent follow-up PET/CT once yearly thereafter. Forty-two months after the eyelid surgery, PET/CT showed intense tracer uptake in the right lower abdomen. An ascending colon tumor was identified, and examination of a biopsy specimen showed adenocarcinoma. In case 2, a 77-year-old man presented for evaluation of three continuous papules with telangiectasia on his right cheek. Examination of a skin biopsy specimen of the cheek papule revealed a sebaceous carcinoma. He underwent PET/CT to detect other malignancies. PET/CT showed intense tracer uptake in the sigmoid colon. A sigmoid colon tumor was identified, and examination of a biopsy specimen showed adenocarcinoma. Both patients underwent resection of their tumors, and both were still free of recurrence of the sebaceous and colon carcinomas at the time of this writing. CONCLUSION: PET/CT is a reliable imaging modality for the detection of internal malignancies and is useful for the diagnosis and follow-up of MTS.

Systemic factors related to soluble (pro)renin receptor in plasma of patients with proliferative diabetic retinopathy
Keitaro Hase, Atsuhiro Kanda, Lkuyo Hirose, Kousuke Noda, Susumu Ishida
PLOS ONE, 12, 12, e0189696, 2017年12月, ［査読有り］
英語, 研究論文（学術雑誌）

糖尿病網膜症における新規血管新生因子ガレクチン-1の発現調節メカニズム　　　　　　　　　　　　　　　
神田 敦宏, 野田 航介, 齋藤 航, 石田 晋
生命科学系学会合同年次大会, 2017年度, [1P, 0023], 生命科学系学会合同年次大会運営事務局, 2017年12月
日本語

Long-term follow-up of conjunctival melanoma treated with topical interferon alpha-2b eye drops as adjunctive therapy following surgical resection
Iku Kikuchi, Satoru Kase, Kan Ishijima, Susumu Ishida
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 255, 11, 2271, 2276, 2017年11月, ［査読有り］
英語, 研究論文（学術雑誌）

Advanced glycation endproducts link inflammatory cues to upregulation of galectin-1 in diabetic retinopathy
Atsuhiro Kanda, Yoko Dong, Kousuke Noda, Wataru Saito, Susumu Ishida
SCIENTIFIC REPORTS, 7, 1, 16168, 2017年11月, ［査読有り］
英語, 研究論文（学術雑誌）

A case of cancer-Associated retinopathy successfully treated with systemic corticosteroids and extraction of ovarian cancer　　　　　　　　　　　　　　　
Rika Yamada, Katsuya Yamazoe, Yumi Kusumi, Atsuhiro Kanda, Wataru Saito, Susumu Ishida, Kazuki Hotta
Folia Japonica de Ophthalmologica Clinica, 10, 11, 913, 917, Association of Folia Ophthalmologica Japonica, 2017年11月01日
日本語, 研究論文（国際会議プロシーディングス）

Usefulness of Flow Cytometry in Diagnosis of IgG4-Related Ophthalmic Disease and Extranodal Marginal Zone B-Cell Lymphoma of the Ocular Adnexa
Satoru Kase, Kan Ishijima, Takehiko Uraki, Yuka Suimon, Yasuo Suzuki, Manabu Kase, Susumu Ishida
ANTICANCER RESEARCH, 37, 9, 5001, 5004, 2017年09月, ［査読有り］
英語, 研究論文（学術雑誌）

Intracorneal hematoma in a case of oculocutaneous albinism　　　　　　　　　　　　　　　
Iku Kikuchi, Takeshi Ohguchi, Yoshiaki Tagawa, Riki Kijima, Kazuomi Mizuuchi, Daiju Iwata, Yoshitsugu Tagawa, Susumu Ishida
Japanese Journal of Clinical Ophthalmology, 71, 8, 1227, 1231, Igaku-Shoin Ltd, 2017年08月01日
日本語, 研究論文（学術雑誌）

A Novel Single-Strand RNAi Therapeutic Agent Targeting the (Pro)renin Receptor Suppresses Ocular Inflammation
Atsuhiro Kanda, Erdal Tan Ishizuka, Atsushi Shibata, Takahiro Matsumoto, Hidekazu Toyofuku, Kousuke Noda, Kenichi Namba, Susumu Ishida
MOLECULAR THERAPY-NUCLEIC ACIDS, 7, 116, 126, 2017年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Vascular Adhesion Protein-1 Blockade Suppresses Ocular Inflammation After Retinal Laser Photocoagulation in Mice
Takashi Matsuda, Kousuke Noda, Miyuki Murata, Akiko Kawasaki, Atsuhiro Kanda, Yukihiko Mashima, Susumu Ishida
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58, 7, 3254, 3261, 2017年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Effect of topical rebamipide on goblet cells in the lid wiper of human conjunctiva
Satoru Kase, Toshiya Shinohara, Manabu Kase, Susumu Ishida
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 13, 6, 3516, 3522, 2017年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Blood flow velocity and thickness of the choroid in a patient with chorioretinopathy associated with ocular blunt trauma
Yuri Ishikawa, Yuki Hashimoto, Wataru Saito, Ryo Ando, Susumu Ishida
BMC OPHTHALMOLOGY, 17, 1, 86, 2017年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Catastrophic Thermal Corneoscleral Injury Treated with Transplantation of Donor Scleral Graft
Satoru Kase, Takeshi Ohguchi, Susumu Ishida
Case Reports in Ophthalmology, 8, 2, 349, 352, S. Karger AG, 2017年05月08日, ［査読有り］
英語, 研究論文（学術雑誌）

Histological findings in the trabecular meshwork of a patient with atopic glaucoma
Satoru Kase, Shiki Chin, Teruhiko Hamanaka, Yasuhiro Shinmei, Takeshi Ohguchi, Riki Kijima, Akira Matsuda, Susumu Ishida
Open Ophthalmology Journal, 11, 103, 106, Bentham Science Publishers B.V., 2017年05月01日, ［査読有り］
英語

Evaluating the efficacy of epinastine ophthalmic solution using a conjunctivitis allergen challenge model in patients with birch pollen allergic conjunctivitis
Yoshiaki Tagawa, Kenichi Namba, Yumi Nakazono, Daiju Iwata, Susumu Ishida
ALLERGOLOGY INTERNATIONAL, 66, 2, 338, 343, 2017年04月, ［査読有り］
英語, 研究論文（学術雑誌）

Improvements of visual function and outer retinal morphology following spontaneous regression of cancer in anti-recoverin cancer-associated retinopathy
Yuka Suimon, Wataru Saito, Kiriko Hirooka, Atsuhiro Kanda, Hidenori Kitai, Jun Sakakibara-Konishi, Susumu Ishida
American Journal of Ophthalmology Case Reports, 5, 137, 140, Elsevier Inc, 2017年04月01日, ［査読有り］
英語, 研究論文（学術雑誌）

Vascular anomaly in the levator aponeurosis of neurofibromatosis type 1
Satoru Kase, Toshiya Shinohara, Mika Noda, Susumu Ishida, Manabu Kase
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, 10, 4, 656, 657, 2017年04月, ［査読有り］
英語, 研究論文（学術雑誌）

Pathologic Roles of Receptor-Associated Prorenin System in Idiopathic Epiretinal Membrane
Yoko Dong, Atsuhiro Kanda, Kousuke Noda, Wataru Saito, Susumu Ishida
SCIENTIFIC REPORTS, 7, 44266, 2017年03月, ［査読有り］
英語, 研究論文（学術雑誌）

Visual field constriction in a case of cerebrospinal fluid hypovolemia following traffic accident　　　　　　　　　　　　　　　
Kayo Suzuki, Akihiro Takahashi, Yasuhiro Shinmei, Yoshiaki Tagawa, Mayo Nozaki, Kan Ishijima, Shinki Chin, Susumu Ishida
Japanese Journal of Clinical Ophthalmology, 71, 3, 301, 307, Igaku-Shoin Ltd, 2017年03月01日
日本語, 研究論文（学術雑誌）

Long-term use of tacrolimus ophthalmic suspension for vernal keratoconjunctivitis　　　　　　　　　　　　　　　
Mayuko Shinagawa, Kenichi Namba, Nobuyoshi Kitaichi, Susumu Ishida
Japanese Journal of Clinical Ophthalmology, 71, 3, 343, 348, Igaku-Shoin Ltd, 2017年03月01日
日本語, 研究論文（学術雑誌）

Early post-treatment choroidal thickness to alert sunset glow fundus in patients with Vogt-Koyanagi- Harada disease treated with systemic corticosteroids
Kiriko Hirooka, Wataru Saito, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Yuki Hashimoto, Susumu Ishida
PLOS ONE, 12, 2, e0172612, 2017年02月, ［査読有り］
英語, 研究論文（学術雑誌）

HLA-B51 Carriers are Susceptible to Ocular Symptoms of Behçet Disease and the Association between the Two Becomes Stronger towards the East along the Silk Road: A Literature Survey.
Horie Y, Meguro A, Ohta T, Lee EB, Namba K, Mizuuchi K, Iwata D, Mizuki N, Ota M, Inoko H, Ishida S, Ohno S, Kitaichi N
Ocular immunology and inflammation, 25, 1, 37, 40, 2017年, ［査読有り］
英語, 研究論文（学術雑誌）

Localization of Acrolein-Lysine Adduct in Fibrovascular Tissues of Proliferative Diabetic Retinopathy
Yoko Dong, Kousuke Noda, Miyuki Murata, Shiho Yoshida, Wataru Saito, Atsuhiro Kanda, Susumu Ishida
CURRENT EYE RESEARCH, 42, 1, 111, 117, 2017年01月, ［査読有り］
英語, 研究論文（学術雑誌）

Serial Frequencies and Clinical Features of Uveitis in Hokkaido, Japan
Daiju Iwata, Kazuomi Mizuuchi, Koki Aoki, Yukihiro Horie, Satoru Kase, Kenichi Namba, Shigeaki Ohno, Susumu Ishida, Nobuyoshi Kitaichi
OCULAR IMMUNOLOGY AND INFLAMMATION, 25, sup1, S15, S18, 2017年, ［査読有り］
英語, 研究論文（学術雑誌）

Clinical practice pattern in management of diabetic macular edema in Japan: survey results of Japanese retinal specialists
Yuichiro Ogura, Fumio Shiraga, Hiroko Terasaki, Masahito Ohji, Susumu Ishida, Taiji Sakamoto, Akito Hirakata, Tatsuro Ishibashi
JAPANESE JOURNAL OF OPHTHALMOLOGY, 61, 1, 43, 50, 2017年01月, ［査読有り］
英語, 研究論文（学術雑誌）

Relationship between Choroidal Thickness and Visual Field Impairment in Acute Zonal Occult Outer Retinopathy
Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Yuka Hasegawa, Akari Takita, Shohei Mori, Kousuke Noda, Susumu Ishida
JOURNAL OF OPHTHALMOLOGY, 2017, 2371032, 2017年, ［査読有り］
英語, 研究論文（学術雑誌）

Clinical and histological evaluation of large macular hole surgery using the inverted internal limiting membrane flap technique
Satoru Kase, Wataru Saito, Shohei Mori, Michiyuki Saito, Ryo Aando, Zhenyu Dong, Tomohiro Suzuki, Kousuke Noda, Susumu Ishida
Clinical Ophthalmology, 11, 9, 14, Dove Medical Press Ltd, 2017年01月01日, ［査読有り］
英語, 研究論文（学術雑誌）

Evaluation of the Safety and Tolerability of Conjunctival Ring for Posterior Segment of the Eye
Satoshi Kinoshita, Takeshi Ohguchi, Kousuke Noda, Miyuki Murata, Shin-ichi Yasueda, Haruka Obata, Toru Matsunaga, Tsutomu Fukushima, Atsuhiro Kanda, Susumu Ishida
CURRENT EYE RESEARCH, 42, 8, 1149, 1154, 2017年, ［査読有り］
英語, 研究論文（学術雑誌）

Relationship between choroidal thickness and visual impairment in multiple evanescent white dot syndrome
Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Yuka Hasegawa, Shohei Mori, Kousuke Noda, Susumu Ishida
ACTA OPHTHALMOLOGICA, 94, 8, E804, E806, 2016年12月, ［査読有り］
英語

Invariant natural killer T cells play dual roles in the development of experimental autoimmune uveoretinitis
Masashi Satoh, Ken-ichi Namba, Nobuyoshi Kitaichi, Noriko Endo, Hirokuni Kitamei, Daiju Iwata, Shigeaki Ohno, Susumu Ishida, Kazunori Onoe, Hiroshi Watarai, Masaru Taniguchi, Tatsuro Ishibashi, Joan Stein-Streilein, Koh-Hei Sonoda, Luc Van Kaer, Kazuya Iwabuchi
EXPERIMENTAL EYE RESEARCH, 153, 79, 89, 2016年12月, ［査読有り］
英語, 研究論文（学術雑誌）

Choroidal circulation impairment during the anterior recurrence of Vogt-Koyanagi-Harada disease confirmed with indocyanine green angiography and laser speckle flowgraphy
Yuko Takemoto, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Tomoe Uno, Shigeaki Ohno, Kiriko Hirooka, Yuki Hashimoto, Wataru Saito, Kazuhisa Sugiyama, Susumu Ishida
ACTA OPHTHALMOLOGICA, 94, 7, E629, E636, 2016年11月, ［査読有り］
英語, 研究論文（学術雑誌）

Modified 360-degree suture trabeculotomy combined with phacoemulsification and intraocular lens implantation for glaucoma and coexisting cataract
Yasuhiro Shinmei, Riki Kijima, Takuya Nitta, Kan Ishijima, Takeshi Ohguchi, Shinki Chin, Susumu Ishida
JOURNAL OF CATARACT AND REFRACTIVE SURGERY, 42, 11, 1634, 1641, 2016年11月, ［査読有り］
英語, 研究論文（学術雑誌）

Effect of geranylgeranylacetone on the protection of retinal ganglion cells in a mouse model of normal tension glaucoma.
Zhenyu Dong, Yasuhiro Shinmei, Yoko Dong, Saori Inafuku, Junichi Fukuhara, Ryo Ando, Nobuyoshi Kitaichi, Atsuhiro Kanda, Kohichi Tanaka, Kousuke Noda, Takayuki Harada, Shinki Chin, Susumu Ishida
Heliyon, 2, 10, e00191, 2016年10月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, Glaucoma is characterized by axonal degeneration of retinal ganglion cells (RGCs) and apoptotic death of their cell bodies, and lowering intraocular pressure is associated with an attenuation of progressive optic nerve damage. Nevertheless, intraocular pressure (IOP) reduction alone was not enough to inhibit the progression of disease, which suggests the contribution of other factors to the glaucoma pathogenesis. In this study, we investigated the cytoprotective effect of geranylgeranylacetone (GGA) on RGCs degeneration using a normal tension glaucoma (NTG) mouse model, which lacks glutamate/aspartate transporter (GLAST) and demonstrates spontaneous RGC and optic nerve degeneration without elevated intraocular pressure (IOP). Three-week-old GLAST+/- mice were given oral administration of GGA at 100, 300, or 600 mg/kg/day or vehicle alone, and littermate control mice were given vehicle alone for 14 days, respectively. At 5 weeks after birth, the number of RGCs was counted in paraffin sections of retinal tissues stained with hematoxylin and eosin. In addition, retrograde labeling technique was also used to quantify the number of RGC. Expression and localization of heat shock protein 70 (HSP70) in retinas were evaluated by reverse transcription polymerase chain reaction and immunohistochemistry, respectively. Activities of caspase-9 and -3 in retinas were also assessed. The number of RGCs of GLAST+/- mice significantly decreased, as compared to that of control mice. RGC loss was significantly suppressed by administration of GGA at 600 mg/kg/day, compared with vehicle alone. Following GGA administration, HSP70 was significantly upregulated together with reduction in the activities of caspase-9 and -3. Our studies highlight HSP70 induction in the retina is available to suppress RGC degeneration, and thus GGA may be applicable for NTG as a promising therapy.

Vitreous levels of vascular endothelial growth factor-B in proliferative diabetic retinopathy
Satoshi Kinoshita, Kousuke Noda, Wataru Saito, Atsuhiro Kanda, Susumu Ishida
ACTA OPHTHALMOLOGICA, 94, 6, E521, E523, 2016年09月, ［査読有り］
英語

Regulation of vascular endothelial growth factor-C by tumor necrosis factor-α in the conjunctiva and pterygium.
Dong Y, Kase S, Dong Z, Fukuhara J, Tagawa Y, Ishizuka ET, Murata M, Shinmei Y, Ohguchi T, Kanda A, Noda K, Ishida S
International journal of molecular medicine, 38, 2, 545, 550, 2016年08月, ［査読有り］
英語, 研究論文（学術雑誌）

Phosphorylation of alphaB-crystallin in epiretinal membrane of human proliferative diabetic retinopathy
Yoko Dong, Zhenyu Dong, Satoru Kase, Ryo Ando, Junichi Fukuhara, Satoshi Kinoshita, Saori Inafuku, Yoshiaki Tagawa, Erdal Tan Ishizuka, Wataru Saito, Miyuki Murata, Atsuhiro Kanda, Kousuke Noda, Susumu Ishida
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, 9, 8, 1100, 1105, 2016年08月, ［査読有り］
英語, 研究論文（学術雑誌）

Occult hypertensive choroidopathy: novel finding of suprachoroidal fluid
Wataru Saito, Michiyuki Saito, Yuki Hashimoto, Susumu Ishida
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 254, 6, 1229, 1231, 2016年06月, ［査読有り］
英語

Increased choroidal blood flow velocity with regression of acute posterior multifocal placoid pigment epitheliopathy
Kiriko Hirooka, Wataru Saito, Michiyuki Saito, Yuki Hashimoto, Shohei Mori, Kousuke Noda, Susumu Ishida
JAPANESE JOURNAL OF OPHTHALMOLOGY, 60, 3, 172, 178, 2016年05月, ［査読有り］
英語, 研究論文（学術雑誌）

Continuous Intraocular Pressure Monitoring During Nocturnal Sleep in Patients With Obstructive Sleep Apnea Syndrome
Yasuhiro Shinmei, Takuya Nitta, Hiroshi Saito, Takeshi Ohguchi, Riki Kijima, Shinki Chin, Susumu Ishida
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57, 6, 2824, 2830, 2016年05月, ［査読有り］
英語, 研究論文（学術雑誌）

Choroidal thickening prior to anterior recurrence in patients with Vogt-Koyanagi-Harada disease
Yoshiaki Tagawa, Kenichi Namba, Kazuomi Mizuuchi, Yuko Takemoto, Daiju Iwata, Tomoe Uno, Takako Fukuhara, Kiriko Hirooka, Nobuyoshi Kitaichi, Shigeaki Ohno, Susumu Ishida
BRITISH JOURNAL OF OPHTHALMOLOGY, 100, 4, 473, 477, 2016年04月, ［査読有り］
英語, 研究論文（学術雑誌）

[Etiology of diabetic retinopathy].
Noda K, Ishida S
Nihon rinsho. Japanese journal of clinical medicine, 74 Suppl 2, 107, 111, 2016年04月, ［査読有り］, ［国内誌］
日本語, 研究論文（学術雑誌）

Diagnostic efficacy of cell block method for vitreoretinal lymphoma
Satoru Kase, Kenichi Namba, Daiju Iwata, Kazuomi Mizuuchi, Nobuyoshi Kitaichi, Yoshiaki Tagawa, Hiromi Okada-Kanno, Yoshihiro Matsuno, Susumu Ishida
DIAGNOSTIC PATHOLOGY, 11, 29, 2016年03月, ［査読有り］
英語, 研究論文（学術雑誌）

Short Communication: Increase of Sialylated N-Glycansin Eyes with Neovascular Glaucoma Secondary to Proliferative Diabetic Retinopathy
Saori Inafuku, Kousuke Noda, Maho Amano, Shin-Ichiro Nishimura, Susumu Ishida
CURRENT EYE RESEARCH, 41, 5, 721, 724, 2016年, ［査読有り］
英語, 研究論文（学術雑誌）

A Case of Severe Panuveitis Associated with Psoriasis Vulgaris Successfully Treated with Infliximab
Yuri Sakurai, Kenichi Namba, Kazuomi Mizuuchi, Toshihumi Nomura, Susumu Ishida
Case Reports in Ophthalmology, 7, 1, 191, 194, S. Karger AG, 2016年, ［査読有り］
英語, 研究論文（学術雑誌）

Receptor-associated prorenin system contributes to development of inflammation and angiogenesis in proliferative diabetic retinopathy.
Kanda A, Ishida S
Inflammation and regeneration, 36, 22, 2016年, ［査読有り］

Ocular Behçet's disease is less complicated with allergic disorders. A nationwide survey in Japan.
Horie Y, Kitaichi N, Hijioka K, Sonoda KH, Saishin Y, Kezuka T, Goto H, Takeuchi M, Nakamura S, Kimoto T, Shimakawa M, Kita M, Sugita S, Mochizuki M, Hori J, Iwata M, Shoji J, Fukuda M, Kaburaki T, Numaga J, Kawashima H, Fukushima A, Joko T, Takai N, Ozawa Y, Meguro A, Mizuki N, Namba K, Ishida S, Ohno S
Clinical and experimental rheumatology, 34, 6 Suppl 102, 111, 114, Clinical and Experimental Rheumatology S.A.S., 2016年, ［査読有り］
英語, 研究論文（学術雑誌）

A case of tuberculous endophthalmitis successfully treated with vitrectomy followed by antituberculous agents
Keitaro Hase, Kenichi Namba, Wataru Saito, Shigeaki Ohno, Susumu Ishida
Journal of Ophthalmic Inflammation and Infection, 5, 1, 14, Springer Verlag, 2015年12月01日, ［査読有り］
英語, 研究論文（学術雑誌）

Aflibercept Traps Galectin-1, an Angiogenic Factor Associated with Diabetic Retinopathy
Atsuhiro Kanda, Kousuke Noda, Wataru Saito, Susumu Ishida
SCIENTIFIC REPORTS, 5, 17946, 2015年12月, ［査読有り］
英語, 研究論文（学術雑誌）

Significant role of the choroidal outer layer during recovery from choroidal thickening in Vogt-Koyanagi-Harada disease patients treated with systemic corticosteroids
Kiriko Hirooka, Wataru Saito, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Yuki Hashimoto, Susumu Ishida
BMC OPHTHALMOLOGY, 15, 181, 2015年12月, ［査読有り］
英語, 研究論文（学術雑誌）

多発消失性白点症候群における脈絡膜厚の経時的変化
橋本 勇希, 齋藤 航, 齋藤 理幸, 廣岡 季里子, 森 祥平, 野田 航介, 石田 晋
日本視能訓練士協会誌, 44, 199, 199, (公社)日本視能訓練士協会, 2015年12月
日本語

Measurement of interleukins in vitreous infusion fluid.
Kase S, Yokoi M, Ishida S, Kase M
Biomedical reports, 3, 6, 818, 820, Spandidos Publications, 2015年11月, ［査読有り］
英語, Measurements of interleukin (IL)-6 and -10 concentrations in the vitreous can be used to differentiate intraocular lymphoma (IOL) from uveitis. This is the first study reporting the IL-6 and -10 concentrations in the undiluted vitreous fluid and vitreous infusion fluid, which were simultaneously examined in the patients. A total of 2 females presented with intraocular inflammation, and underwent pars plana vitrectomy. Undiluted anterior vitreous and vitreous infusion fluid were collected simultaneously. IL concentrations were determined by enzyme-linked immunosorbent assay systems. Vitreous infusion fluid of 20 ml was eventually collected following completion of core vitrectomy in the two patients. IL-6 concentrations of the first patient were 513 and 106 pg/ml in the undiluted vitreous and the infusion fluid, respectively, while those of the second patient were 263 and 29 pg/ml. By contrast, IL-10 was under the detectable levels in all the fluids. The IL-10/-6 ratio was <1 in both fluids in the patients. Cytological examination revealed the presence of reactive inflammatory cells in the vitreous fluid. The two patients were eventually diagnosed with uveitis. Measurements of IL concentrations in the vitreous infusion fluid provided significant evidence on the differential diagnosis between IOL and uveitis, when considering how vitreous infusion fluid was diluted. The present study highlighted a novel application of cytokine analyses using the vitreous infusion fluid, which may contribute to the development of future translational researches on uveitis/IOL patients.

[Retinal Cell Biology and Molecular Targeting Therapy--Post-VEGF Era for Innovative Drug Development].
Ishida S
Nippon Ganka Gakkai zasshi, 119, 11, 759, 760, 2015年11月, ［査読有り］

Pulse Waveform Changes in Macular Choroidal Hemodynamics With Regression of Acute Central Serous Chorioretinopathy
Michiyuki Saito, Wataru Saito, Kiriko Hirooka, Yuki Hashimoto, Shohei Mori, Kousuke Noda, Susumu Ishida
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56, 11, 6515, 6522, 2015年10月, ［査読有り］
英語, 研究論文（学術雑誌）

A case of choroidal malignant melanoma with vitreal dissemination　　　　　　　　　　　　　　　
Hanae Yokoyama, Satoru Kase, Yasuo Suzuki, Satoshi Katsuta, Mitsuo Takahashi, Toshiya Shinohara, Susumu Ishida, Manabu Kase
Japanese Journal of Clinical Ophthalmology, 69, 10, 1545, 1550, Igaku-Shoin Ltd, 2015年10月01日
日本語, 研究論文（学術雑誌）

Multiple evanescent white dot syndrome associated with retinal vasculitis
Akihiro Takahashi, Wataru Saito, Yuki Hashimoto, Susumu Ishida
International Medical Case Reports Journal, 8, 209, 213, Dove Medical Press Ltd, 2015年09月21日, ［査読有り］
英語, 研究論文（学術雑誌）

Decreased choroidal blood flow velocity in the pathogenesis of multiple evanescent white dot syndrome
Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Kiriko Hirooka, Shohei Mori, Kousuke Noda, Susumu Ishida
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 253, 9, 1457, 1464, 2015年09月, ［査読有り］
英語, 研究論文（学術雑誌）

SRPK1/CK2阻害活性を有する新規血管新生阻害局所薬　　　　　　　　　　　　　　　
諸岡 諭, 伊藤 暢聡, 細谷 孝充, 野田 航介, 石田 晋, 萩原 正敏, 吉村 長久
日本眼薬理学会プログラム・抄録集, 35回, 49, 49, 日本眼薬理学会, 2015年09月
日本語

Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice
Satoshi Morooka, Mitsuteru Hoshina, Isao Kii, Takayoshi Okabe, Hirotatsu Kojima, Naoko Inoue, Yukiko Okuno, Masatsugu Denawa, Suguru Yoshida, Junichi Fukuhara, Kensuke Ninomiya, Teikichi Ikura, Toshio Furuya, Tetsuo Nagano, Kousuke Noda, Susumu Ishida, Takamitsu Hosoya, Nobutoshi Ito, Nagahisa Yoshimura, Masatoshi Hagiwara
MOLECULAR PHARMACOLOGY, 88, 2, 316, 325, 2015年08月, ［査読有り］
英語, 研究論文（学術雑誌）

Alteration of N-Glycan Profiles in Diabetic Retinopathy
Saori Inafuku, Kousuke Noda, Maho Amano, Tetsu Ohashi, Chikako Yoshizawa, Wataru Saito, Miyuki Murata, Atsuhiro Kanda, Shin-Ichiro Nishimura, Susumu Ishida
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56, 9, 5316, 5322, 2015年08月, ［査読有り］
英語, 研究論文（学術雑誌）

Changes in Inner and Outer Retinal Layer Thicknesses after Vitrectomy for Idiopathic Macular Hole: Implications for Visual Prognosis
Yuki Hashimoto, Wataru Saito, Akio Fujiya, Chikako Yoshizawa, Kiriko Hirooka, Shohei Mori, Kousuke Noda, Susumu Ishida
PLOS ONE, 10, 8, e0135925, 2015年08月, ［査読有り］
英語, 研究論文（学術雑誌）

Increased choroidal blood flow velocity with regression of unilateral acute idiopathic maculopathy
Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Kiriko Hirooka, Shohei Mori, Kousuke Noda, Susumu Ishida
JAPANESE JOURNAL OF OPHTHALMOLOGY, 59, 4, 252, 260, 2015年07月, ［査読有り］
英語, 研究論文（学術雑誌）

Increased vascular endothelial growth factor level in the subretinal fluid of eye with vasoproliferative retinal tumors
Akio Fujiya, Kousuke Noda, Shiho Yoshida, Wataru Saito, Susumu Ishida
Retinal Cases and Brief Reports, 9, 2, 154, 156, Lippincott Williams and Wilkins, 2015年04月06日, ［査読有り］
英語, 研究論文（学術雑誌）

Relationship between choroidal blood flow velocity and choroidal thickness during systemic corticosteroid therapy for Vogt-Koyanagi-Harada disease
Kiriko Hirooka, Wataru Saito, Kenichi Namba, Yuko Takemoto, Kazuomi Mizuuchi, Tomoe Uno, Yoshiaki Tagawa, Yuki Hashimoto, Susumu Ishida
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 253, 4, 609, 617, 2015年04月, ［査読有り］
英語, 研究論文（学術雑誌）

ATP6AP2/(pro)renin receptor contributes to glucose metabolism via stabilizing the pyruvate dehydrogenase E1 β subunit.
Kanda A, Noda K, Ishida S
The Journal of biological chemistry, 290, 15, 9690, 9700, 2015年04月, ［査読有り］
英語, 研究論文（学術雑誌）

Acute Zonal Occult Outer Retinopathy in Japanese Patients: Clinical Features, Visual Function, and Factors Affecting Visual Function
Saho Saito, Wataru Saito, Michiyuki Saito, Yuki Hashimoto, Shohei Mori, Kousuke Noda, Kenichi Namba, Susumu Ishida
PLOS ONE, 10, 4, e0125133, 2015年04月, ［査読有り］
英語, 研究論文（学術雑誌）

Macular thickness changes in a patient with Leber's hereditary optic neuropathy
Ayako Mizoguchi, Yuki Hashimoto, Yasuhiro Shinmei, Mayo Nozaki, Kan Ishijima, Yoshiaki Tagawa, Susumu Ishida
BMC OPHTHALMOLOGY, 15, 27, 2015年03月, ［査読有り］
英語, 研究論文（学術雑誌）

Single center study on ethnic and clinical features of Behcet's disease in Moscow, Russia
Anton Lennikov, Zemfira Alekberova, Regina Goloeva, Nobuyoshi Kitaichi, Lev Denisov, Kenichi Namba, Mitsuhiro Takeno, Yoshiaki Ishigatsubo, Nobuhisa Mizuki, Eugeny Nasonov, Susumu Ishida, Shigeaki Ohno
CLINICAL RHEUMATOLOGY, 34, 2, 321, 327, 2015年02月, ［査読有り］
英語, 研究論文（学術雑誌）

Single center study on ethnic and clinical features of Behcet's disease in Moscow, Russia.
Anton Lennikov, Zemfira Alekberova, Regina Goloeva, Nobuyoshi Kitaichi, Lev Denisov, Kenichi Namba, Mitsuhiro Takeno, Yoshiaki Ishigatsubo, Nobuhisa Mizuki, Eugeny Nasonov, Susumu Ishida, Shigeaki Ohno
Clinical rheumatology, 34, 2, 321, 7, 2015年02月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, For the purpose of investigating Behcet's disease (BD) in Russia, 250 consecutive patients (177 men and 73 women) diagnosed with BD between 1990 and 2010 at the Research Institute of Rheumatology, Russian Academy of Medical Sciences in Moscow were enrolled in this study. The ethnic backgrounds of the patients were reported as follows: 23.2% (58 cases) from Russia, 12.8% (32 cases) from Azerbaijan, 14.4% (36 cases) from Armenia, 8.8% (22 cases) from Chechnya, and 21.6% (55 cases) from Dagestan. The remaining 19.2% (48 cases) were from other regions or of unknown origin. More than half (57.6%) of the Behcet's disease patients originated from Central Asia, specifically Azerbaijan, Armenia, Chechnya, and Dagestan. The mean age at disease onset was 31.5 ± 9.38 (13-60) years old, and the most typical initial manifestations were oral aphthous ulcers. Patients aged 20-39 years old were more commonly affected and displayed a wide clinical spectrum of the disease, with varieties of severe internal organ involvement. The manifestations observed throughout the course of the disease included oral aphthous ulcers (100%), various cutaneous lesions (88.8%), genital ulcers (81.2%), and ocular lesions (54.0%). Besides these, many organs/systems were implicated in patient cases, namely joint (53.2%), vascular (25.2%), neurological (8.0%), gastrointestinal (25.2%), and cardiac (5.6%) systems. Involvements of ocular (p < 0.01) and skin (p < 0.01) lesions were more frequent in men than in women. HLA-B51 and HLA-A26 typing was performed in 127 patients and 508 healthy controls. HLA-B51 was found in 63.0% of BD patients compared to 20.7% of the healthy control subjects (p < 0.001), and HLA-A26 was present in 11.3% of BD patients and 18.9% of the control group. This study shows the presence of BD in Russia, and it is suggested that its prevalence in Central Asian people is much higher than that in White Russian.

Involvement of the Receptor-Associated Prorenin System in the Pathogenesis of Human Conjunctival Lymphoma
Erdal Tan Ishizuka, Atsuhiro Kanda, Satoru Kase, Kousuke Noda, Susumu Ishida
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56, 1, 74, 80, 2015年01月, ［査読有り］
英語, 研究論文（学術雑誌）

A case of mature natural killer-cell neoplasm manifesting multiple choroidal lesions: Primary intraocular natural killer-cell lymphoma
Yoshiaki Tagawa, Reiki Ogasawara, Hiromi Kanno, Susumu Ishida, Kenichi Namba
Case Reports in Ophthalmology, 6, 3, 380, 384, S. Karger AG, 2015年, ［査読有り］
英語, 研究論文（学術雑誌）

Enhanced-depth Imaging Optical Coherence Tomography and Laser Speckle Flowgraphy in a Patient with Acute Macular Neuroretinopathy
Kiriko Hirooka, Wataru Saito, Kousuke Noda, Susumu Ishida
OCULAR IMMUNOLOGY AND INFLAMMATION, 22, 6, 485, 489, 2014年12月, ［査読有り］
英語

Amelioration of experimental autoimmune uveoretinitis by inhibition of glyceraldehyde-derived advanced glycation end-product formation
Zhenyu Dong, Daiju Iwata, Nobuyoshi Kitaichi, Masayoshi Takeuchi, Masashi Sato, Noriko Endo, Kazuya Iwabuchi, Ryo Ando, Junichi Fukuhara, Satoshi Kinoshita, Anton Lennikov, Mizuki Kitamura, Kazuomi Mizuuchi, Atsuhiro Kanda, Kousuke Noda, Kenichi Namba, Sho-Ichi Yamagishi, Shigeaki Ohno, Susumu Ishida
JOURNAL OF LEUKOCYTE BIOLOGY, 96, 6, 1077, 1085, 2014年12月, ［査読有り］
英語, 研究論文（学術雑誌）

Retinal outer layer thickness increases with regression of multiple evanescent white dot syndrome and visual improvement positively correlates with photoreceptor outer segment length
Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Kiriko Hirooka, Chikako Yoshizawa, Kousuke Noda, Susumu Ishida
ACTA OPHTHALMOLOGICA, 92, 7, e591, e592, 2014年11月, ［査読有り］
英語

Genistein attenuates choroidal neovascularization
Satoshi Kinoshita, Kousuke Noda, Yoshiaki Tagawa, Saori Inafuku, Yoko Dong, Junichi Fukuhara, Zhenyu Dong, Ryo Ando, Atsuhiro Kanda, Susumu Ishida
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 25, 11, 1177, 1182, 2014年11月, ［査読有り］
英語, 研究論文（学術雑誌）

Acquired focal choroidal excavation associated with multiple evanescent white dot syndrome: observations at onset and a pathogenic hypothesis
Yuki Hashimoto, Wataru Saito, Kousuke Noda, Susumu Ishida
BMC Ophthalmology, 14, 135, 2014年11月, ［査読有り］
英語, 研究論文（学術雑誌）

多発消失性白点症候群における脈絡膜厚の経時的変化　　　　　　　　　　　　　　　
橋本 勇希, 齋藤 航, 齋藤 理幸, 廣岡 季里子, 森 祥平, 野田 航介, 石田 晋
日本視能矯正学会プログラム抄録集, 55回, 46, 46, 日本視能矯正学会, 2014年11月
日本語

Impaired Circulation in the Thickened Choroid of a Patient with Serpiginous Choroiditis
Ai Takahashi, Wataru Saito, Yuki Hashimoto, Michiyuki Saito, Susumu Ishida
OCULAR IMMUNOLOGY AND INFLAMMATION, 22, 5, 409, 413, 2014年10月, ［査読有り］
英語

[Japan phase 3 study of pegaptanib sodium in patients with diabetic macular edema].
Ishibashi T, Yuzawa M, Yoshimura N, Ohji M, Ishida S, Isogawa N, Esaka E
Nippon Ganka Gakkai zasshi, 118, 9, 773, 782, 日本眼科学会, 2014年09月, ［査読有り］
日本語

Intertypic modular exchanges of genomic segments by homologous recombination at universally conserved segments in human adenovirus species D
Gabriel Gonzalez, Kanako O. Koyanagi, Koki Aoki, Nobuyoshi Kitaichi, Shigeaki Ohno, Hisatoshi Kaneko, Susumu Ishida, Hidemi Watanabe
GENE, 547, 1, 10, 17, 2014年08月, ［査読有り］
英語, 研究論文（学術雑誌）

A comparison of N-glycan profiles in human plasma and vitreous fluid
Saori Inafuku, Kousuke Noda, Maho Amano, Tetsu Ohashi, Chikako Yoshizawa, Wataru Saito, Atsuhiro Kanda, Shin-Ichiro Nishimura, Susumu Ishida
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 252, 8, 1235, 1243, 2014年08月, ［査読有り］
英語, 研究論文（学術雑誌）

Decreased proteasomal activity causes photoreceptor degeneration in mice
Ryo Ando, Kousuke Noda, Utano Tomaru, Mamoru Kamoshita, Yoko Ozawa, Shoji Notomi, Toshio Hisatomi, Mika Noda, Atsuhiro Kanda, Tatsuro Ishibashi, Masanori Kasahara, Susumu Ishida
Investigative Ophthalmology and Visual Science, 55, 7, 4682, 4690, Association for Research in Vision and Ophthalmology Inc., 2014年07月03日, ［査読有り］
英語, 研究論文（学術雑誌）

Oxidative Stress in the Levator Aponeurosis in Asian Involutional Blepharoptosis
Satoru Kase, Mika Noda, Hiroshi Yoshikawa, Teppei Yamamoto, Kan Ishijima, Susumu Ishida
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY, 30, 4, 290, 294, 2014年07月, ［査読有り］
英語, 研究論文（学術雑誌）

Pars Plana Vitrectomy for Macular Schisis Associated With Peripapillary Intrachoroidal Cavitation
Chikako Yoshizawa, Wataru Saito, Kousuke Noda, Susumu Ishida
OPHTHALMIC SURGERY LASERS & IMAGING RETINA, 45, 4, 350, 353, 2014年07月, ［査読有り］
英語, 研究論文（学術雑誌）

[A review 59 molecular mechanisms in and medical treatments for diabetic retinopathy].
Ishida S
Nippon Ganka Gakkai zasshi, 118, 7, 607, 618, 日本眼科学会, 2014年07月, ［査読有り］
日本語, 研究論文（学術雑誌）, コレクション : 国立国会図書館デジタルコレクション > デジタル化資料 > 雑誌

Expression of Vascular Endothelial Growth Factor in Human Ocular Adnexal Lymphoma
Satoshi Kinoshita, Satoru Kase, Ryo Ando, Zhenyu Dong, Junichi Fukuhara, Yoko Dong, Saori Inafuku, Kousuke Noda, Mika Noda, Atsuhiro Kanda, Susumu Ishida
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55, 6, 3461, 3467, 2014年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Adenosquamous carcinoma of the conjunctiva: A case report
Satoru Kase, Hiroshi Yoshikawa, Yutaka Nakajima, Mika Noda, Susumu Ishida
ONCOLOGY LETTERS, 7, 6, 1941, 1943, 2014年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Aqueous humour levels of placental growth factor in diabetic retinopathy
Ryo Ando, Kousuke Noda, Shiho Namba, Wataru Saito, Atsuhiro Kanda, Susumu Ishida
ACTA OPHTHALMOLOGICA, 92, 3, E245, E246, 2014年05月, ［査読有り］
英語

Increased macular choroidal blood flow velocity and decreased choroidal thickness with regression of punctate inner choroidopathy
Kiriko Hirooka, Wataru Saito, Yuki Hashimoto, Michiyuki Saito, Susumu Ishida
BMC OPHTHALMOLOGY, 14, 73, 2014年05月, ［査読有り］
英語, 研究論文（学術雑誌）

Roles of the retinal pigment epithelium in neuroprotection
Atsuhiro Kanda, Susumu Ishida
Neuroprotection and Neuroregeneration for Retinal Diseases, 227, 238, Springer Japan, 2014年05月01日, ［査読有り］
英語, 論文集(書籍)内論文

Correlation between decreased choroidal blood flow velocity and the pathogenesis of acute zonal occult outer retinopathy
Michiyuki Saito, Wataru Saito, Yuki Hashimoto, Chikako Yoshizawa, Yasuhiro Shinmei, Kousuke Noda, Susumu Ishida
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 42, 2, 139, 150, 2014年03月, ［査読有り］
英語, 研究論文（学術雑誌）

Retinal outer layer thickness increases after vitrectomy for epiretinal membrane, and visual improvement positively correlates with photoreceptor outer segment length
Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Kiriko Hirooka, Akio Fujiya, Chikako Yoshizawa, Kousuke Noda, Susumu Ishida
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 252, 2, 219, 226, 2014年02月, ［査読有り］
英語, 研究論文（学術雑誌）

Amelioration of endotoxin-induced uveitis treated with the sea urchin pigment echinochrome in rats
Anton Lennikov, Nobuyoshi Kitaichi, Kousuke Noda, Kazuomi Mizuuchi, Ryo Ando, Zhenyu Dong, Junichi Fukuhara, Satoshi Kinoshita, Kenichi Namba, Shigeaki Ohno, Susumu Ishida
MOLECULAR VISION, 20, 171, 177, 2014年02月, ［査読有り］
英語, 研究論文（学術雑誌）

Safety and pressure-lowering effect of switching to 0.03% bimatoprost for primary open-angle glaucoma　　　　　　　　　　　　　　　
Masahiko Naka, Maria Yamamoto, Xehai Jin, Chiaki Yokoyama, Kan Ishijima, Nobuyoshi Kitaichi, Takeshi Ohguchi, Takuya Nitta, Yasuhiro Shinmei, Shinki Chin, Susumu Ishida
Japanese Journal of Clinical Ophthalmology, 68, 2, 219, 224, 2014年02月
日本語, 研究論文（学術雑誌）

Increase of lysosomal phospholipase A2 in aqueous humor by uveitis
Miki Hiraoka, Akira Abe, Anton Lennikov, Nobuyoshi Kitaichi, Susumu Ishida, Hiroshi Ohguro
EXPERIMENTAL EYE RESEARCH, 118, 13, 19, 2014年01月, ［査読有り］
英語, 研究論文（学術雑誌）

A case of paraneoplastic optic neuropathy and outer retinitis positive for autoantibodies against collapsin response mediator protein-5, recoverin, and α-enolase.
Saito M, Saito W, Kanda A, Ohguro H, Ishida S
BMC ophthalmology, 14, 5, 2014年01月, ［査読有り］
英語, 研究論文（学術雑誌）

A patient with acute zonal occult outer retinopathy who developed zonal retinal degeneration along retinal veins 5 years after the onset　　　　　　　　　　　　　　　
Yuka Hasegawa, Wataru Saito, Yuki Hashimoto, Saho Saito, Susumu Ishida
Folia Japonica de Ophthalmologica Clinica, 7, 7, 531, 535, Association of Folia Ophthalmologica Japonica, 2014年
日本語, 研究論文（学術雑誌）

A challenging case of malingering mimicking psychogenic visual impairment with higher brain dysfunction　　　　　　　　　　　　　　　
Sayaka Ishigaki, Yasuhiro Shinmei, Ayako Mizoguchi, Shinki Chin, Susumu Ishida
Neuro-Ophthalmology Japan, 31, 1, 52, 56, Neuro-Ophthalmology Society of Japan, 2014年
日本語, 研究論文（学術雑誌）

Presumed paraneoplastic retinopathy in a case of leiomyosarcoma　　　　　　　　　　　　　　　
Akihiro Takahashi, Wataru Saito, Michiyuki Saito, Daiju Iwata, Atsuhiro Kanda, Susumu Ishida
Japanese Journal of Clinical Ophthalmology, 68, 6, 819, 824, Igaku-Shoin Ltd, 2014年
日本語, 研究論文（学術雑誌）

Atp6ap2/(Pro)renin Receptor Interacts with Par3 as a Cell Polarity Determinant Required for Laminar Formation during Retinal Development in Mice
Atsuhiro Kanda, Kousuke Noda, Kenya Yuki, Yoko Ozawa, Takahisa Furukawa, Atsuhiro Ichihara, Susumu Ishida
JOURNAL OF NEUROSCIENCE, 33, 49, 19341, 19351, 2013年12月, ［査読有り］
英語, 研究論文（学術雑誌）

網膜中心静脈閉塞症を合併したacute macular neuroretinopathyの1例
廣岡 季里子, 齋藤 航, 橋本 勇希, 齋藤 理幸, 吉澤 史子, 野田 航介, 石田 晋
日本視能訓練士協会誌, 42, 228, 229, (公社)日本視能訓練士協会, 2013年12月
日本語

The Effects of 2% Rebamipide Ophthalmic Solution on the Tear Functions and Ocular Surface of the Superoxide Dismutase-1 (Sod1) Knockout Mice
Takeshi Ohguchi, Takashi Kojima, Osama M. Ibrahim, Taeko Nagata, Takahiko Shimizu, Takuji Shirasawa, Tetsuya Kawakita, Yoshiyuki Satake, Kazuo Tsubota, Jun Shimazaki, Susumu Ishida
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54, 12, 7793, 7802, 2013年11月, ［査読有り］
英語, 研究論文（学術雑誌）

EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND INTRAVITREAL ANTI-VEGF THERAPY WITH BEVACIZUMAB IN VASOPROLIFERATIVE RETINAL TUMORS
Wataru Saito, Satoru Kase, Akio Fujiya, Zhenyu Dong, Kousuke Noda, Susumu Ishida
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 33, 9, 1959, 1967, 2013年10月, ［査読有り］
英語, 研究論文（学術雑誌）

Spontaneous regression of IgG4-related dacryoadenitis
Satoru Kase, Teppei Yamamoto, Kan Ishijima, Mika Noda, Susumu Ishida
Modern Rheumatology, 23, 5, 1018, 1021, 2013年09月, ［査読有り］
英語, 研究論文（学術雑誌）

Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease
Yun Jong Lee, Yukihiro Horie, Graham R. Wallace, Yong Seok Choi, Ji Ah Park, Ji Yong Choi, Ran Song, Young-Mo Kang, Seong Wook Kang, Han Joo Baek, Nobuyoshi Kitaichi, Akira Meguro, Nobuhisa Mizuki, Kenichi Namba, Susumu Ishida, Jinhyun Kim, Edyta Niemczyk, Eun Young Lee, Yeong Wook Song, Shigeaki Ohno, Eun Bong Lee
ANNALS OF THE RHEUMATIC DISEASES, 72, 9, 1510, 1516, 2013年09月, ［査読有り］
英語, 研究論文（学術雑誌）

Expression of αB-crystallin and vascular endothelial growth factor in conjunctival squamous cell carcinoma.
Dong Z, Kase S, Ando R, Fukuhara J, Kinoshita S, Dong Y, Takashina S, Kanda A, Noda M, Noda K, Ishida S
Anticancer research, 33, 9, 3745, 3751, 2013年09月, ［査読有り］
英語, 研究論文（学術雑誌）

[Bioinformatics on new human adenoviruses causing nosocomial infection].
Koki Aoki, Hisatoshi Kaneko, Nobuyoshi Kitaichi, Hidemi Watanabe, Susumu Ishida, Shigeaki Ohno
Nippon Ganka Gakkai zasshi, 117, 9, 721, 6, 2013年09月, ［査読有り］, ［国内誌］
日本語, Human adenovirus (HAdV) causing epidemic keratoconjunctivitis is limited to D and E species. Recent progress in bioinformatics revealed that these viruses attach to the host with fibers, infiltrate the host cells via RGD (Arg-Gly-Asp) motif of penton base, and reveal their serological reaction by hexons. Loops 1 and 2 are the variable regions of each hexon. The possibility that a novel adenovirus later named HAdV-52 was transmitted over the wall of species' from monkeys to humans was reported. The recombination of the above three hot spots introduces novel types such as HAdV-53, -54, and -56. Boinformatics may provide rapid genotyping in nosocomial infection, predicting future epidemics, and an estimate of the therapeutic target molecules in the near future.

エキノクロームによるラットEIUの軽症化　　　　　　　　　　　　　　　
アントン・レニコフ, 北市 伸義, 野田 航介, 南場 研一, 石田 晋, 大野 重昭, 大黒 浩
日本眼薬理学会プログラム・抄録集, 33回, 44, 44, 日本眼薬理学会, 2013年09月
日本語

Choroid blood flow measurement with laser speckle flowgraphy in macular disease
Seong-Woo Kim, Jaeryung Oh
BRITISH JOURNAL OF OPHTHALMOLOGY, 97, 8, 1083, 1084, 2013年08月, ［査読有り］
英語

Blockade for vascular adhesion protein-1 suppresses pathological neovascularization in oxygen-induced retinopathy
Nami Yoshikawa, Kousuke Noda, Yoko Ozawa, Yukihiko Mashima, Susumu Ishida
ACTA OPHTHALMOLOGICA, 91, 5, E409, E410, 2013年08月, ［査読有り］
英語

A patient with acute macular neuroretinopathy and central retinal vein occlusion
Kiriko Hirooka, Wataru Saito, Kousuke Noda, Susumu Ishida
Clinical Ophthalmology, 7, 1447, 1450, 2013年07月12日, ［査読有り］
英語, 研究論文（学術雑誌）

Improvement of visual acuity after transcorneal electrical stimulation in case of Best vitelliform macular dystrophy
Naoki Ozeki, Kei Shinoda, Hisao Ohde, Susumu Ishida, Kazuo Tsubota
Graefe's Archive for Clinical and Experimental Ophthalmology, 251, 7, 1867, 1870, 2013年07月, ［査読有り］
英語, 研究論文（学術雑誌）

Clinical features of human T lymphotropic virus type 1-associated uveitis in Hokkaido, Japan
Satoru Kase, Kenichi Namba, Nobuyoshi Kitaichi, Daiju Iwata, Shigeaki Ohno, Susumu Ishida
JAPANESE JOURNAL OF OPHTHALMOLOGY, 57, 4, 379, 384, 2013年07月, ［査読有り］
英語, 研究論文（学術雑誌）

TNF-α decreases VEGF secretion in highly polarized RPE cells but increases it in non-polarized RPE cells related to crosstalk between JNK and NF-κB pathways.
Terasaki H, Kase S, Shirasawa M, Otsuka H, Hisatomi T, Sonoda S, Ishida S, Ishibashi T, Sakamoto T
PloS one, 8, 7, e69994, 2013年07月, ［査読有り］
英語, 研究論文（学術雑誌）

A case of paraneoplastic retinopathy diagnosed after vitrectomy for proliferative diabetic retinopathy　　　　　　　　　　　　　　　
Hiroshi Shimizu, Wataru Saito, Michiyuki Saito, Hiroshi Oguro, Susumu Ishida
Japanese Journal of Clinical Ophthalmology, 67, 8, 1349, 1355, 2013年07月
日本語, 研究論文（学術雑誌）

Macular choroidal blood flow velocity decreases with regression of acute central serous chorioretinopathy
Michiyuki Saito, Wataru Saito, Yuki Hashimoto, Chikako Yoshizawa, Akio Fujiya, Kousuke Noda, Susumu Ishida
BRITISH JOURNAL OF OPHTHALMOLOGY, 97, 6, 775, 780, 2013年06月, ［査読有り］
英語, 研究論文（学術雑誌）

IgG4-related Inflammation of the Orbit Simulating Malignant Lymphoma
Satoru Kase, Mika Noda, Kan Ishijima, Teppei Yamamoto, Kanako Hatanaka, Susumu Ishida
ANTICANCER RESEARCH, 33, 6, 2779, 2783, 2013年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Angiotensin II Type 1 Receptor Antagonist Attenuates Lacrimal Gland, Lung, and Liver Fibrosis in a Murine Model of Chronic Graft-Versus-Host Disease
Saori Yaguchi, Yoko Ogawa, Shigeto Shimmura, Tetsuya Kawakita, Shin Hatou, Shingo Satofuka, Shigeru Nakamura, Toshihiro Imada, Hideyuki Miyashita, Satoru Yoshida, Tomonori Yaguchi, Yoko Ozawa, Takehiko Mori, Shinichiro Okamoto, Yutaka Kawakami, Susumu Ishida, Kazuo Tsubota
PLOS ONE, 8, 6, e64724, 2013年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Membrane tissue on the optic disc may cause macular schisis associated with a glaucomatous optic disc without optic disc pits
S. Saori, W. Wataru, Kousuke Noda, Maki Katai, Susumu Ishida
Clinical Ophthalmology, 7, 883, 887, 2013年05月10日, ［査読有り］
英語, 研究論文（学術雑誌）

Trabecular meshwork depigmentation in Vogt-Koyanagi-Harada disease.
Kazuomi Mizuuchi, Nobuyoshi Kitaichi, Kenichi Namba, Yukihiro Horie, Susumu Ishida, Shigeaki Ohno
Japanese journal of ophthalmology, 57, 3, 245, 51, 2013年05月, ［査読有り］, ［国内誌］
英語, PURPOSE: Since some patients develop depigmentation of the trabecular meshwork in the course of Vogt-Koyanagi-Harada (VKH) disease, we examined the incidence of trabecular depigmentation and its correlation with other ocular findings and systemic symptoms. METHODS: We retrospectively reviewed the clinical charts of 53 Japanese patients diagnosed with VKH disease. The scores of trabecular and limbal pigmentation of all patients were recorded. We then examined the correlation between trabecular pigmentation and the presence of sunset glow fundus or skin lesions. RESULTS: Trabecular pigmentation was significantly lower in the patients with sunset glow fundus than in those without it (P = 0.022), whereas limbal pigmentation showed no significance. However, there were no significant differences in trabecular and limbal pigmentation between the patients with and those without skin lesions. Furthermore, there was no correlation between trabecular and limbal pigmentation. CONCLUSIONS: Depigmentation of the trabecular meshwork develops in some patients in the course of VKH disease. This depigmentation is significantly correlated with sunset glow fundus, but not with limbal depigmentation or skin lesions.

Vitreous renin activity correlates with vascular endothelial growth factor in proliferative diabetic retinopathy
Atsuhiro Kanda, Kousuke Noda, Wataru Saito, Susumu Ishida
BRITISH JOURNAL OF OPHTHALMOLOGY, 97, 5, 666, 668, 2013年05月, ［査読有り］
英語

Fifteen years old boy with atypical retinal pigment epitheliopathy at the fovea continuing after the onset of multiple evanescent white dot syndrome　　　　　　　　　　　　　　　
Kiriko Hirooka, Wataru Saito, Yuki Hashimoto, Kousuke Noda, Masayuki Tsutsumi, Naoki Furudate, Susumu Ishida
Folia Japonica de Ophthalmologica Clinica, 6, 4, 278, 282, 2013年04月
日本語, 研究論文（学術雑誌）

Serum Vascular Adhesion Protein-1 correlates with vascular endothelial growth factor in patients with type II diabetes
Nami Yoshikawa, Kousuke Noda, Hajime Shinoda, Atsuro Uchida, Yoko Ozawa, Kazuo Tsubota, Yukihiko Mashima, Susumu Ishida
JOURNAL OF DIABETES AND ITS COMPLICATIONS, 27, 2, 162, 166, 2013年03月, ［査読有り］
英語, 研究論文（学術雑誌）

Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization
Zhenyu Dong, Kousuke Noda, Atsuhiro Kanda, Junichi Fukuhara, Ryo Ando, Miyuki Murata, Wataru Saito, Masatoshi Hagiwara, Susumu Ishida
MOLECULAR VISION, 19, 536, 543, 2013年03月, ［査読有り］
英語, 研究論文（学術雑誌）

Recovery of visual function after corticosteroid pulse therapy in a patient with acute zonal occult outer retinopathy associated with punctuate inner choroidopathy　　　　　　　　　　　　　　　
Saho Saito, Wataru Saito, Yuki Hashimoto, Susumu Ishida
Folia Japonica de Ophthalmologica Clinica, 6, 3, 190, 194, 2013年03月
日本語, 研究論文（学術雑誌）

Expression of vascular endothelial growth factor C in human pterygium
Junichi Fukuhara, Satoru Kase, Tsutomu Ohashi, Ryo Ando, Zhenyu Dong, Kousuke Noda, Takeshi Ohguchi, Atsuhiro Kanda, Susumu Ishida
Histochemistry and Cell Biology, 139, 2, 381, 389, 2013年02月, ［査読有り］
英語, 研究論文（学術雑誌）

Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice.
Anton Lennikov, Nobuyoshi Kitaichi, Satoru Kase, Kousuke Noda, Yukihiro Horie, Akira Nakai, Shigeaki Ohno, Susumu Ishida
International journal of molecular sciences, 14, 1, 2175, 89, 2013年01月22日, ［査読有り］, ［国際誌］
英語, Acute ultraviolet (UV) B exposure causes photokeratitis and induces apoptosis in corneal cells. Geranylgeranylacetone (GGA) is an acyclic polyisoprenoid that induces expression of heat shock protein (HSP)70, a soluble intracellular chaperone protein expressed in various tissues, protecting cells against stress conditions. We examined whether induction of HSP70 has therapeutic effects on UV-photokeratitis in mice. C57 BL/6 mice were divided into four groups, GGA-treated (500 mg/kg/mouse) and UVB-exposed (400 mJ/cm2), GGA-untreated UVB-exposed (400 mJ/cm2), GGA-treated (500 mg/kg/mouse) but not exposed and naive controls. Eyeballs were collected 24 h after irradiation, and corneas were stained with hematoxylin and eosin (H&E) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL). HSP70, reactive oxygen species (ROS) production, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and protein kinase B (Akt) expression were also evaluated. Irradiated corneal epithelium was significantly thicker in the eyes of mice treated with GGA compared with those given the vehicle alone (p < 0.01). Significantly fewer TUNEL-positive cells were observed in the eyes of GGA-treated mice than controls after irradiation (p < 0.01). Corneal HSP70 levels were significantly elevated in corneas of mice treated with GGA (p < 0.05). ROS signal was not affected by GGA. NF-κB activation was reduced but phospho-(Ser/Ther) Akt substrate expression was increased in corneas after irradiation when treated with GGA. GGA-treatment induced HSP70 expression and ameliorated UV-induced corneal damage through the reduced NF-κB activation and possibly increased Akt phosphorilation.

Autoimmune retinopathy associated with colonic adenoma
Wataru Saito, Satoru Kase, Hiroshi Ohguro, Susumu Ishida
Graefe's Archive for Clinical and Experimental Ophthalmology, 251, 5, 1447, 1449, 2013年, ［査読有り］
英語

Photodynamic therapy combined with intravitreal bevacizumab and sub-tenon triamcinolone acetonide injections for age-related macular degeneration
Chikako Yoshizawa, Wataru Saito, Shigeki Hirose, Hirokuni Kitamei, Kousuke Noda, Susumu Ishida
Japanese Journal of Ophthalmology, 57, 1, 68, 73, 2013年01月, ［査読有り］
英語, 研究論文（学術雑誌）

Identification of contamination in the American type culture collection stock of human adenovirus type 8 by whole-genome sequencing.
Shotaro Yamane, Amanda Wei Ling Lee, Nozomu Hanaoka, Gabriel Gonzalez, Hisatoshi Kaneko, Susumu Ishida, Nobuyoshi Kitaichi, Shigeaki Ohno, Kanako O Koyanagi, Koki Aoki, Tsuguto Fujimoto, Nobuyo Yawata, Hidemi Watanabe
Journal of virology, 87, 2, 1285, 6, 2013年01月, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Expression of Vascular Endothelial Growth Factor in Eyes with Coats' Disease
Satoru Kase, Narsing A. Rao, Hiroshi Yoshikawa, Junichi Fukuhara, Kousuke Noda, Atsuhiro Kanda, Susumu Ishida
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54, 1, 57, 62, 2013年01月, ［査読有り］
英語, 研究論文（学術雑誌）

Tissue Kallikrein Attenuates Choroidal Neovascularization via Cleavage of Vascular Endothelial Growth Factor
Junichi Fukuhara, Kousuke Noda, Miyuki Murata, Shiho Namba, Satoshi Kinoshita, Zhenyu Dong, Ryo Ando, Anton Lennikov, Atsuhiro Kanda, Susumu Ishida
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54, 1, 274, 279, 2013年01月, ［査読有り］
英語, 研究論文（学術雑誌）

Two cases of subfoveal choroidal neovascularization with tubulointerstitial nephritis and uveitis syndrome
Yuko Takemoto, Kenichi Namba, Kazuomi Mizuuchi, Shigeaki Ohno, Susumu Ishida
European Journal of Ophthalmology, 23, 2, 255, 257, 2013年, ［査読有り］
英語, 研究論文（学術雑誌）

Bacterial endophthalmitis caused by an intraocular cilium in a patient under treatment with infliximab
Xue-Hai Jin, Kenichi Namba, Wataru Saito, Daiju Iwata, Susumu Ishida
Journal of Ophthalmic Inflammation and Infection, 3, 1, 1, 3, 2013年, ［査読有り］
英語, 研究論文（学術雑誌）

Angiopoietin-like protein 2 mediates endotoxin-induced acute inflammation in the eye
Atsuhiro Kanda, Kousuke Noda, Yuichi Oike, Susumu Ishida
LABORATORY INVESTIGATION, 92, 11, 1553, 1563, 2012年11月, ［査読有り］
英語, 研究論文（学術雑誌）

正常眼における中心窩の錐体外節端(COST)形態と視細胞外節(PROS)長の年代別検討　　　　　　　　　　　　　　　
橋本 勇希, 齋藤 航, 齋藤 理幸, 高橋 亜衣, 藤谷 顕雄, 吉澤 史子, 野田 航介, 石田 晋
日本視能矯正学会プログラム抄録集, 53回, 46, 46, 日本視能矯正学会, 2012年11月
日本語

網膜中心静脈閉塞症を合併したacute macular neuroretinopathyの1例　　　　　　　　　　　　　　　
廣岡 季里子, 齋藤 航, 橋本 勇希, 齋藤 理幸, 吉澤 史子, 野田 航介, 石田 晋
日本視能矯正学会プログラム抄録集, 53回, 55, 55, 日本視能矯正学会, 2012年11月
日本語

健常成人における錐体外節端(COST)ラインの範囲　　　　　　　　　　　　　　　
高橋 亜衣, 齋藤 航, 橋本 勇希, 齋藤 理幸, 藤谷 顕雄, 吉澤 史子, 野田 航介, 石田 晋
日本視能矯正学会プログラム抄録集, 53回, 67, 67, 日本視能矯正学会, 2012年11月
日本語

(Pro)renin receptor is associated with angiogenic activity in proliferative diabetic retinopathy
A. Kanda, K. Noda, W. Saito, S. Ishida
DIABETOLOGIA, 55, 11, 3104, 3113, 2012年11月, ［査読有り］
英語, 研究論文（学術雑誌）

Increased macular choroidal blood flow velocity during systemic corticosteroid therapy in a patient with acute macular neuroretinopathy
Yuki Hashimoto, Wataru Saito, Shohei Mori, Michiyuki Saito, Susumu Ishida
Clinical Ophthalmology, 6, 1, 1645, 1649, 2012年10月08日, ［査読有り］
英語, 研究論文（学術雑誌）

Amelioration of endotoxin-induced uveitis treated with an IκB kinase β inhibitor in rats.
Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Fukuhara J, Kinoshita S, Namba K, Mizutani M, Fujikawa T, Itai A, Ohno S, Ishida S
Molecular vision, 18, 267-70, 2586, 2597, 2012年10月, ［査読有り］
英語, 研究論文（学術雑誌）

Clinical Features of Central Retinal Vein Occlusion With Inflammatory Etiology.
Yoshizawa C, Saito W, Kase M, Ishida S
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.), 1, 5, 270, 276, 2012年09月, ［査読有り］

Conjunctival lymphoma arising from reactive lymphoid hyperplasia
Junichi Fukuhara, Satoru Kase, Mika Noda, Kan Ishijima, Teppei Yamamoto, Susumu Ishida
WORLD JOURNAL OF SURGICAL ONCOLOGY, 10, 194, 2012年09月, ［査読有り］
英語, 研究論文（学術雑誌）

Reduction of Intraocular Pressure Using a Modified 360-degree Suture Trabeculotomy Technique in Primary and Secondary Open-Angle Glaucoma: A Pilot Study
Shinki Chin, Takuya Nitta, Yasuhiro Shinmei, Maiko Aoyagi, Akari Nitta, Shigeaki Ohno, Susumu Ishida, Kazuhiko Yoshida
JOURNAL OF GLAUCOMA, 21, 6, 401, 407, 2012年08月, ［査読有り］
英語, 研究論文（学術雑誌）

Presence and Physiologic Function of the Renin-Angiotensin System in Mouse Lacrimal Gland
Saori Yaguchi, Yoko Ogawa, Shigeto Shimmura, Shin Hatou, Shigeru Nakamura, Takaaki Inaba, Toshihiro Imada, Yoko Ozawa, Yutaka Kawakami, Susumu Ishida, Kazuo Tsubota
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 53, 9, 5416, 5425, 2012年08月, ［査読有り］
英語, 研究論文（学術雑誌）

Correlation between elevation of serum antinuclear antibody titer and decreased therapeutic efficacy in the treatment of Behçet's disease with infliximab.
Iwata D, Namba K, Mizuuchi K, Kitaichi N, Kase S, Takemoto Y, Ohno S, Ishida S
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 250, 7, 1081, 1087, 2012年07月, ［査読有り］
英語, 研究論文（学術雑誌）

[Etiology of diabetic retinopathy].
Ishida S
Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 5, 343, 348, 2012年07月, ［査読有り］

Replication of a microsatellite genome-wide association study of Behcet's disease in a Korean population
Yukihiro Horie, Akira Meguro, Nobuyoshi Kitaichi, Eun Bong Lee, Atsuhiro Kanda, Kousuke Noda, Yeong Wook Song, Kyung Sook Park, Kenichi Namba, Masao Ota, Hidetoshi Inoko, Nobuhisa Mizuki, Susumu Ishida, Shigeaki Ohno
RHEUMATOLOGY, 51, 6, 983, 986, 2012年06月, ［査読有り］
英語, 研究論文（学術雑誌）

ALPHAB-CRYSTALLIN EXPRESSION IN EPIRETINAL MEMBRANE OF HUMAN PROLIFERATIVE DIABETIC RETINOPATHY
Zhenyu Dong, Satoru Kase, Ryo Ando, Junichi Fukuhara, Wataru Saito, Atsuhiro Kanda, Miyuki Murata, Kousuke Noda, Susumu Ishida
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 32, 6, 1190, 1196, 2012年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Soluble Vascular Adhesion Protein-1 Accumulates in Proliferative Diabetic Retinopathy
Miyuki Murata, Kousuke Noda, Junichi Fukuhara, Atsuhiro Kanda, Satoru Kase, Wataru Saito, Yoko Ozawa, Satsuki Mochizuki, Shioko Kimura, Yukihiko Mashima, Yasunori Okada, Susumu Ishida
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 53, 7, 4055, 4062, 2012年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Receptor-associated prorenin system in the pathogenesis of retinal diseases
Shingo Satofuka, Atsuhiro Kanda, Susumu Ishida
Frontiers in Bioscience - Scholar, 4, 4, 1449, 1460, 2012年06月01日, ［査読有り］
英語, 研究論文（学術雑誌）

Biological role of lutein in the light-induced retinal degeneration
Mariko Sasaki, Kenya Yuki, Toshihide Kurihara, Seiji Miyake, Kosuke Noda, Saori Kobayashi, Susumu Ishida, Kazuo Tsubota, Yoko Ozawa
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 23, 5, 423, 429, 2012年05月, ［査読有り］
英語, 研究論文（学術雑誌）

Spontaneous Regression of Intraocular Lymphoma
Satoru Kase, Kenichi Namba, Xue-Hai Jin, Kanako C. Kubota, Susumu Ishida
OPHTHALMOLOGY, 119, 5, 1083, 1084, 2012年05月, ［査読有り］
英語

Chickenpox chorioretinitis with retinal exudates and periphlebitis.
Hirokuni Kitamei, Kenichi Namba, Nobuyoshi Kitaichi, Akiko Wakayama, Shigeaki Ohno, Susumu Ishida
Case reports in ophthalmology, 3, 2, 180, 4, 2012年05月, ［査読有り］, ［国際誌］
英語, BACKGROUND: Chickenpox is rarely associated with posterior segment inflammation. We report on a case of unilateral chickenpox chorioretinitis with retinal exudates and periphlebitis. CASE PRESENTATION: A 21-year-old healthy man, who suffered from chickenpox 2 weeks prior to symptom development, exhibited mild anterior chamber cells, vitreous opacity, sheathing of retinal veins, and yellow-white exudates in his right eye. Varicella zoster virus DNA was detected by polymerase chain reaction in the aqueous humor. He was treated with intravenous acyclovir followed by oral prednisolone and valaciclovir. Aqueous cells quickly disappeared and retinal exudates diminished within 1 month, leaving faint retinal scarring. Retinal arteritis had never been observed in this patient. CONCLUSIONS: ALTHOUGH THE OCULAR FINDINGS IN THIS CASE WERE SIMILAR TO ACUTE RETINAL NECROSIS (ARN), THE CLINICAL FEATURES DIFFERED FROM ARN IN THE FOLLOWING POINTS: (1) mild anterior chamber inflammation, (2) absence of retinal arteritis, and (3) prompt resolution of inflammatory findings. The distinctive clinical features indicated that chorioretinitis associated with chickenpox may not have the same pathological conditions as ARN.

Blockade of vascular adhesion protein-1 attenuates choroidal neovascularization
Nami Yoshikawa, Kousuke Noda, Yoko Ozawa, Kazuo Tsubota, Yukihiko Mashima, Susumu Ishida
MOLECULAR VISION, 18, 60-65, 593, 600, 2012年03月, ［査読有り］
英語, 研究論文（学術雑誌）

Expression of α-crystallin in the retina of human sympathetic ophthalmia.
Kase S, Meghpara BB, Ishida S, Rao NA
Molecular medicine reports, 5, 2, 395, 399, 2012年02月, ［査読有り］
英語, 研究論文（学術雑誌）

Astaxanthin increases choroidal blood flow velocity
Michiyuki Saito, Kazuhiko Yoshida, Wataru Saito, Akio Fujiya, Kazuhiro Ohgami, Nobuyoshi Kitaichi, Hiroki Tsukahara, Susumu Ishida, Shigeaki Ohno
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 250, 2, 239, 245, 2012年02月, ［査読有り］
英語, 研究論文（学術雑誌）

Amelioration of ultraviolet-induced photokeratitis in mice treated with astaxanthin eye drops
Anton Lennikov, Nobuyoshi Kitaichi, Risa Fukase, Miyuki Murata, Kousuke Noda, Ryo Ando, Takeshi Ohguchi, Tetsuya Kawakita, Shigeaki Ohno, Susumu Ishida
MOLECULAR VISION, 18, 49, 455, 464, 2012年02月, ［査読有り］
英語, 研究論文（学術雑誌）

Leukocyte Adhesion Molecules in Diabetic Retinopathy
Kousuke Noda, Shintaro Nakao, Susumu Ishida, Tatsuro Ishibashi
JOURNAL OF OPHTHALMOLOGY, 2012, 279037, 2012年, ［査読有り］
英語

Immunolocalization of Vascular Adhesion Protein-1 in Human Conjunctival Tumors
Junichi Fukuhara, Satoru Kase, Kousuke Noda, Miyuki Murata, Mika Noda, Ryo Ando, Zhenyu Dong, Atsuhiro Kanda, Susumu Ishida
OPHTHALMIC RESEARCH, 48, 1, 33, 37, 2012年, ［査読有り］
英語, 研究論文（学術雑誌）

Renin-angiotensin system hyperactivation can induce inflammation and retinal neural dysfunction
Toshihide Kurihara, Yoko Ozawa, Susumu Ishida, Hideyuki Okano, Kazuo Tsubota
International Journal of Inflammation, 2012, 581695, 2012年, ［査読有り］
英語

Ectopic cilia: A histopathological study
Keitaro Hase, Satoru Kase, Mika Noda, Tsutomu Ohashi, Satoru Shinkuma, Susumu Ishida
Case Reports in Dermatology, 4, 1, 37, 40, 2012年01月, ［査読有り］
英語, 研究論文（学術雑誌）

Abnormalities of fundus autofluorescence in pigmented paravenous chorioretinal atrophy
Yuki Hashimoto, Satoru Kase, Wataru Saito, Susumu Ishida
Open Ophthalmology Journal, 6, 125, 128, 2012年, ［査読有り］
英語, 研究論文（学術雑誌）

Acute visual field defect following vitrectomy determined to originate from optic nerve by electrophysiological tests
Atsuro Uchida, Kei Shinoda, Celso Soiti Matsumoto, Miho Kawai, Sayaka Kawai, Hisao Ohde, Yoko Ozawa, Susumu Ishida, Makoto Inoue, Atsushi Mizota, Kazuo Tsubota
Case Reports in Ophthalmology, 3, 3, 396, 405, 2012年, ［査読有り］
英語, 研究論文（学術雑誌）

Intravitreal injection of bevacizumab in a case of occlusive retinal vasculitis accompanied by syphilitic intraocular inflammation
Kan Ishijima, Kenichi Namba, Shigeaki Ohno, Kiyofumi Mochizuki, Susumu Ishida
Case Reports in Ophthalmology, 3, 3, 434, 437, 2012年, ［査読有り］
英語, 研究論文（学術雑誌）

加齢黄斑変性の予防医学
石田 晋
学術の動向, 17, 12, 12_80, 12_85, Japan Science Support Foundation, 2012年
日本語

Presence and physiologic function of the renin-angiotensin system in mouse lacrimal gland
Yaguchi, S, Ogawa, Y, Shimmura, S, Hatou, S, Nakamura, S, Inaba, T, Imada, T, Ozawa, Y, Kawakami, Y, Ishida, S, Tsubota, K
Invest Ophthalmol Vis Sci, 53, 9, 5416, 25, 2012年
英語, PURPOSE: To investigate the expression, localization, and physiologic function of renin-angiotensin system (RAS) components in the mouse lacrimal gland. METHODS: Lacrimal glands and cultured lacrimal gland fibroblasts from wild-type (WT) BALB/c (H-2(d)) mice were used. Reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry were used to determine the expression and localization of the RAS components, prorenin/renin, angiotensin-converting enzyme (ACE), angiotensin II, angiotensin II type 1 receptor (AT1R), and angiotensin II type 2 receptor (AT2R) in the normal mouse lacrimal gland. To examine the change in tear secretion, mice received ARB (AT1R blocker) or AT2R antagonist. Tear secretion was assessed by cotton thread test before and after drug administration. RESULTS: The mRNAs coding for angiotensinogen, prorenin, ACE, and both AT1R and AT2R were found in normal lacrimal gland tissue and cultured lacrimal gland fibroblasts. Prorenin/renin and ACE were identified in myoepithelial cells around ducts and acini and in blood vessels. Angiotensin II, AT1R, and AT2R were observed in the ducts and interstitial fibroblasts. AT1R and AT2R were also localized in b

Neuroprotective response after photodynamic therapy: Role of vascular endothelial growth factor
Misa Suzuki, Yoko Ozawa, Shunsuke Kubota, Manabu Hirasawa, Seiji Miyake, Kousuke Noda, Kazuo Tsubota, Kazuaki Kadonosono, Susumu Ishida
JOURNAL OF NEUROINFLAMMATION, 8, 176, 2011年12月, ［査読有り］
英語, 研究論文（学術雑誌）

Intraocular neovascularization associated with choroidal ganglioneuroma in neurofibromatosis type 1
Kan Ishijima, Satoru Kase, Mika Noda, Susumu Ishida
EUROPEAN JOURNAL OF OPHTHALMOLOGY, 21, 6, 837, 840, 2011年11月, ［査読有り］
英語, 研究論文（学術雑誌）

Roles of AMP-Activated Protein Kinase in Diabetes-Induced Retinal Inflammation
Shunsuke Kubota, Yoko Ozawa, Toshihide Kurihara, Mariko Sasaki, Kenya Yuki, Seiji Miyake, Kousuke Noda, Susumu Ishida, Kazuo Tsubota
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 52, 12, 9142, 9148, 2011年11月, ［査読有り］
英語, 研究論文（学術雑誌）

Genome variability of human adenovirus type 8 causing epidemic keratoconjunctivitis during 1986-2003 in Japan
Xue-Hai Jin, Koki Aoki, Nobuyoshi Kitaichi, Toshihide Ariga, Susumu Ishida, Shigeaki Ohno
MOLECULAR VISION, 17, 336-37, 3121, 3127, 2011年11月, ［査読有り］
英語, 研究論文（学術雑誌）

[Two cases of conjunctival malignant melanoma treated with topical interferon alpha-2b drop as an adjuvant therapy].
Kase S, Ishijima K, Noda M, Ishida S
Nippon Ganka Gakkai zasshi, 115, 11, 1043, 1047, 日本眼科学会, 2011年11月, ［査読有り］
日本語

Increased expression of αA-crystallin in human diabetic eye.
Kase S, Ishida S, Rao NA
International journal of molecular medicine, 28, 4, 505, 511, 2011年10月, ［査読有り］
英語, 研究論文（学術雑誌）

GEP100-Arf6-AMAP1-Cortactin Pathway Frequently Used in Cancer Invasion Is Activated by VEGFR2 to Promote Angiogenesis
Ari Hashimoto, Shigeru Hashimoto, Ryo Ando, Kosuke Noda, Eiji Ogawa, Hirokazu Kotani, Mayumi Hirose, Toshi Menju, Masaki Morishige, Toshiaki Manabe, Yoshinobu Toda, Susumu Ishida, Hisataka Sabe
PLOS ONE, 6, 8, e23359, 2011年08月, ［査読有り］
英語, 研究論文（学術雑誌）

A case of herpes zoster ophthalmicus with acute dacryoadenitis as the initial manifestation　　　　　　　　　　　　　　　
Chiaki Yokoyama, Shohei Mori, Asako Kamada, Satoru Kase, Susumu Ishida
Japanese Journal of Clinical Ophthalmology, 65, 6, 945, 948, 2011年06月15日
日本語, 研究論文（国際会議プロシーディングス）

Recombination analysis of intermediate human adenovirus type 53 in Japan by complete genome sequence
Hisatoshi Kaneko, Koki Aoki, Susumu Ishida, Shigeaki Ohno, Nobuyoshi Kitaichi, Hiroaki Ishiko, Tsuguto Fujimoto, Yoshifumi Ikeda, Masako Nakamura, Gabriel Gonzalez, Kanako O. Koyanagi, Hidemi Watanabe, Tatsuo Suzutani
JOURNAL OF GENERAL VIROLOGY, 92, Pt 6, 1251, 1259, 2011年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Retinal Ganglion Cell Loss in Superoxide Dismutase 1 Deficiency
Kenya Yuki, Yoko Ozawa, Tetsu Yoshida, Toshihide Kurihara, Manabu Hirasawa, Naoki Ozeki, Daisuke Shiba, Kousuke Noda, Susumu Ishida, Kazuo Tsubota
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 52, 7, 4143, 4150, 2011年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Incidence of Increased Intraocular Pressure after Subtenon Injection of Triamcinolone Acetonide
Ryosuke Kawamura, Makoto Inoue, Hajime Shinoda, Kei Shinoda, Yuji Itoh, Susumu Ishida, Kazuo Tsubota
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 27, 3, 299, 304, 2011年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Repair of blowout orbital floor fracture by periosteal suturing
Mika Noda, Kousuke Noda, Shinji Ideta, Yasuhisa Nakamura, Susumu Ishida, Makoto Inoue, Kazuo Tsubota
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 39, 4, 364, 369, 2011年05月, ［査読有り］
英語, 研究論文（学術雑誌）

Extranodal marginal zone B-cell lymphoma involving superior rectus muscle: A clinicopathological case report
Junichi Fukuhara, Satoru Kase, Mika Noda, Kan Ishijima, Susumu Ishida
ONCOLOGY LETTERS, 2, 3, 489, 491, 2011年05月, ［査読有り］
英語, 研究論文（学術雑誌）

Transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization
Manabu Hirasawa, Kousuke Noda, Setsuko Noda, Misa Suzuki, Yoko Ozawa, Kei Shinoda, Makoto Inoue, Yoko Ogawa, Kazuo Tsubota, Susumu Ishida
MOLECULAR VISION, 17, 137, 1222, 1230, 2011年05月, ［査読有り］
英語, 研究論文（学術雑誌）

Detection of human adenovirus hexon antigen using carbon nanotube sensors
Xue-Hai Jin, Atsushi Ishii, Koki Aoki, Susumu Ishida, Koichi Mukasa, Shigeaki Ohno
JOURNAL OF VIROLOGICAL METHODS, 171, 2, 405, 407, 2011年02月, ［査読有り］
英語, 研究論文（学術雑誌）

Conjunctival Lymphoproliferative Disorder
Junichi Fukuhara, Satoru Kase, Kan Ishijima, Mika Noda, Susumu Ishida
OPHTHALMOLOGY, 118, 2, 423, 423, 2011年02月, ［査読有り］
英語

A case of bilateral malignant glaucoma: Different courses in the excising of the peripheral anterior vitreous　　　　　　　　　　　　　　　
Satoshi Kinoshita, Shinki Chin, Shigeki Hirose, Yasuhiro Shinmei, Takuya Nitta, Kazuhiko Yoshida, Susumu Ishida
Folia Japonica de Ophthalmologica Clinica, 4, 2, 143, 147, 2011年02月
日本語, 研究論文（学術雑誌）

Epidemiological and virological features of epidemic keratoconjunctivitis due to new human adenovirus type 54 in Japan
Hisatoshi Kaneko, Tatsuo Suzutani, Koki Aoki, Nobuyoshi Kitaichi, Susumu Ishida, Hiroaki Ishiko, Tsutomu Ohashi, Shigeki Okamoto, Hisashi Nakagawa, Rikutaro Hinokuma, Yoshimori Asato, Shinobu Oniki, Teiko Hashimoto, Tomohiro Iida, Shigeaki Ohno
BRITISH JOURNAL OF OPHTHALMOLOGY, 95, 1, 32, 36, 2011年01月, ［査読有り］
英語, 研究論文（学術雑誌）

Choroidal neovascularization in a patient with blunt trauma-caused traumatic retinopathy without choroidal rupture
Mitsuo Takahashi, Satoshi Kinoshita, Wataru Saito, Manabu Kase, Susumu Ishida
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 249, 1, 137, 140, 2011年01月, ［査読有り］
英語, 研究論文（学術雑誌）

Hydrogen and N-Acetyl-L-Cysteine Rescue Oxidative Stress-Induced Angiogenesis in a Mouse Corneal Alkali-Burn Model
Miyuki Kubota, Shigeto Shimmura, Shunsuke Kubota, Hideyuki Miyashita, Naoko Kato, Kousuke Noda, Yoko Ozawa, Tomohiko Usui, Susumu Ishida, Kazuo Umezawa, Toshihide Kurihara, Kazuo Tsubota
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 52, 1, 427, 433, 2011年01月, ［査読有り］
英語, 研究論文（学術雑誌）

Tissue factor expression in human pterygium
Ryo Ando, Satoru Kase, Tsutomu Ohashi, Zhenyu Dong, Junichi Fukuhara, Atsuhiro Kanda, Miyuki Murata, Kousuke Noda, Nobuyoshi Kitaichi, Susumu Ishida
MOLECULAR VISION, 17, 8-10, 63, 69, 2011年01月, ［査読有り］
英語, 研究論文（学術雑誌）

Evaluation of NLRP1 gene polymorphisms in Vogt-Koyanagi-Harada disease
Yukihiro Horie, Wataru Saito, Nobuyoshi Kitaichi, Toshie Miura, Susumu Ishida, Shigeaki Ohno
JAPANESE JOURNAL OF OPHTHALMOLOGY, 55, 1, 57, 61, 2011年01月, ［査読有り］
英語, 研究論文（学術雑誌）

Diffuse infiltrating retinoblastoma invading subarachnoid space
Satoru Kase, Kazuhiko Yoshida, Shigenobu Suzuki, Koh-Ichi Ohshima, Shigeaki Ohno, Susumu Ishida
Clinical Ophthalmology, 5, 1, 861, 863, 2011年, ［査読有り］
英語, 研究論文（学術雑誌）

18 cases of Acanthamoeba keratitis in the Hokkaido region　　　　　　　　　　　　　　　
Teppei Yamamoto, Takeshi Ohguchi, Hiroki Nishibori, Kimitoshi Nishizaka, Satomi Ariga, Yoshitsugu Tagawa, Susumu Ishida
Folia Japonica de Ophthalmologica Clinica, 4, 1, 20, 23, 2011年01月
日本語, 研究論文（学術雑誌）

Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model
Kubota, M, Shimmura, S, Kubota, S, Miyashita, H, Kato, N, Noda, K, Ozawa, Y, Usui, T, Ishida, S, Umezawa, K, Kurihara, T, Tsubota, K
Invest Ophthalmol Vis Sci, 52, 1, 427, 33, 2011年01月
英語, PURPOSE: To investigate the role of reactive oxygen species (ROS) as the prime initiators of the angiogenic response after alkali injury of the cornea and observe the effects of antioxidants in preventing angiogenesis. METHODS: The corneal epithelia of SOD-1-deficient mice or wild-type (WT) mice were removed after application of 0.15 N NaOH to establish the animal model of alkali burn. ROS production was semiquantitatively measured by dihydroethidium (DHE) fluorescence. Angiogenesis was visualized by CD31 immunohistochemistry. The effects of the specific NF-kappaB inhibitor DHMEQ, the antioxidant N-acetyl-L-cysteine (NAC), and hydrogen (H2) solution were observed. RESULTS: ROS production in the cornea was enhanced immediately after alkali injury, as shown by increased DHE fluorescence (P<0.01). NF-kappaB activation and the upregulation of vascular endothelial growth factor (VEGF) and monocyte chemoattractant protein-1 (MCP-1) were significantly enhanced (P<0.01), leading to a significantly larger area of angiogenesis. Angiogenesis in SOD-1-/- mice corneas were significantly higher in WT mice (P<0.01), confirming the role of ROS. Pretreatment with the specific NF-kappaB inhibitor DH

Calcium Channel Blocker Nilvadipine, but Not Diltiazem, Inhibits Ocular Inflammation in Endotoxin-Induced Uveitis
Susumu Ishida, Takashi Koto, Norihiro Nagai, Yuichi Oike
JAPANESE JOURNAL OF OPHTHALMOLOGY, 54, 6, 594, 601, 2010年11月, ［査読有り］
英語, 研究論文（学術雑誌）

[VEGF blockers].
Ishida S
Nihon rinsho. Japanese journal of clinical medicine, 68 Suppl 9, 304, 309, 2010年11月, ［査読有り］

[Renin-angiotensin system].
Ishida S
Nihon rinsho. Japanese journal of clinical medicine, 68 Suppl 9, 255, 261, 2010年11月, ［査読有り］

Resveratrol Prevents Light-Induced Retinal Degeneration via Suppressing Activator Protein-1 Activation
Shunsuke Kubota, Toshihide Kurihara, Mari Ebinuma, Miyuki Kubota, Kenya Yuki, Mariko Sasaki, Kousuke Noda, Yoko Ozawa, Yuichi Oike, Susumu Ishida, Kazuo Tsubota
AMERICAN JOURNAL OF PATHOLOGY, 177, 4, 1725, 1731, 2010年10月, ［査読有り］
英語, 研究論文（学術雑誌）

Molecular epidemiology of adenoviral keratoconjunctivitis in Saudi Arabia
Khalid F. Tabbara, Nazri Omar, Ehab Hammouda, Masataka Akanuma, Takeshi Ohguchi, Toshihide Ariga, Yoshitsugu Tagawa, Nobuyoshi Kitaichi, Susumu Ishida, Koki Aoki, Hiroaki Ishiko, Shigeaki Ohno
MOLECULAR VISION, 16, 228, 2132, 2136, 2010年10月, ［査読有り］
英語, 研究論文（学術雑誌）

Eicosapentaenoic acid suppresses ocular inflammation in endotoxin-induced uveitis
Misa Suzuki, Kousuke Noda, Shunsuke Kubota, Manabu Hirasawa, Yoko Ozawa, Kazuo Tsubota, Nobuhisa Mizuki, Susumu Ishida
MOLECULAR VISION, 16, 151-52, 1382, 1388, 2010年07月, ［査読有り］
英語, 研究論文（学術雑誌）

Secondary macular hole formation with presumed evulsion of foveal hard exudates in a patient with diabetic retinopathy
Yohei Tomita, Kousuke Noda, Hajime Shinoda, Yoko Ozawa, Kazuo Tsubota, Susumu Ishida
JAPANESE JOURNAL OF OPHTHALMOLOGY, 54, 4, 366, 368, 2010年07月, ［査読有り］
英語

CYCLO-OXYGENASE-2 EXPRESSION IN HUMAN IDIOPATHIC EPIRETINAL MEMBRANE
Satoru Kase, Wataru Saito, Shigeaki Ohno, Susumu Ishida
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 30, 5, 719, 723, 2010年05月, ［査読有り］
英語, 研究論文（学術雑誌）

von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina
Toshihide Kurihara, Yoshiaki Kubota, Yoko Ozawa, Keiyo Takubo, Kousuke Noda, M. Celeste Simon, Randall S. Johnson, Makoto Suematsu, Kazuo Tsubota, Susumu Ishida, Nobuhito Goda, Toshio Suda, Hideyuki Okano
DEVELOPMENT, 137, 9, 1563, 1571, 2010年05月, ［査読有り］
英語, 研究論文（学術雑誌）

Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes.
Sasaki M, Ozawa Y†, Kurihara T, Kubota S, Yuki K, Noda K, Kobayashi S, Ishida S, Tsubota K
Diabetologia, 53, 5, 971, 979, 5, 2010年05月, ［査読有り］

Amelioration of Experimental Autoimmune Uveoretinitis with Nuclear Factor-kappa B Inhibitor Dehydroxy Methyl Epoxyquinomicin in Mice
Daiju Iwata, Nobuyoshi Kitaichi, Akiko Miyazaki, Kazuya Iwabuchi, Kazuhiko Yoshida, Kenichi Namba, Michitaka Ozaki, Shigeaki Ohno, Kazuo Umezawa, Kenichiro Yamashita, Satoru Todo, Susumu Ishida, Kazunori Onoe
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 51, 4, 2077, 2084, 2010年04月, ［査読有り］
英語, 研究論文（学術雑誌）

Merkel Cell Carcinoma of the Conjunctiva
Satoru Kase, Kan Ishijima, Susumu Ishida, Narsing A. Rao
OPHTHALMOLOGY, 117, 3, 637.e1, 2, 2010年03月, ［査読有り］
英語

Mechanism of Visual Sensations Experienced during Pars Plana Vitrectomy under Retrobulbar Anesthesia
Eiko Sugisaka, Kei Shinoda, Ronaldo Yuiti Sano, Susumu Ishida, Yutaka Imamura, Yoko Ozawa, Hajime Shinoda, Kotaro Suzuki, Kazuo Tsubota, Makoto Inoue
OPHTHALMOLOGICA, 224, 2, 103, 108, 2010年, ［査読有り］
英語, 研究論文（学術雑誌）

Prevention of experimental autoimmune uveoretinitis by blockade of osteopontin with small interfering RNA
Daiju Iwata, Mizuki Kitamura, Nobuyoshi Kitaichi, Yoshinari Saito, Shigeyuki Kon, Kenichi Namba, Junko Morimoto, Akiko Ebihara, Hirokuni Kitamei, Kazuhiko Yoshida, Susumu Ishida, Shigeaki Ohno, Toshimitsu Uede, Kazunori Onoe, Kazuya Iwabuchi
EXPERIMENTAL EYE RESEARCH, 90, 1, 41, 48, 2010年01月, ［査読有り］
英語, 研究論文（学術雑誌）

Elevation of surfactant protein D, a pulmonary disease biomarker, in the sera of uveitis patients with sarcoidosis
Nobuyoshi Kitaichi, Mizuki Kitamura, Kenichi Namba, Susumu Ishida, Shigeaki Ohno
JAPANESE JOURNAL OF OPHTHALMOLOGY, 54, 1, 81, 84, 2010年01月, ［査読有り］
英語, 研究論文（学術雑誌）

Combined vitreous and cataract surgeries in highly hyperopic eye
Makoto Inoue, Kei Shinoda, Tomoko Matsuda-Yamamitsu, Ronaldo Yuiti Sano, Susumu Ishida
Clinical Ophthalmology, 4, 1, 1003, 1005, 2010年, ［査読有り］
英語, 研究論文（学術雑誌）

Selective laser trabeculoplasty for elevated intraocular pressure following subtenon injection of triamcinolone acetonide　　　　　　　　　　　　　　　
Kenya Yuki, Makoto Inoue, Daisuke Shiba, Ryosuke Kawamura, Susumu Ishida, Yuichiro Ohtake
Clinical Ophthalmology, 4, 1, 247, 249, 2010年
英語, 研究論文（学術雑誌）

Proliferative Diabetic Retinopathy with Lymphocyte-Rich Epiretinal Membrane Associated with Poor Visual Prognosis
Satoru Kase, Wataru Saito, Shigeaki Ohno, Susumu Ishida
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 50, 12, 5909, 5912, 2009年12月, ［査読有り］
英語, 研究論文（学術雑誌）

Retinal phototoxicity in a novel murine model of intraocular lens implantation
Toshihide Kurihara, Masahiro Omoto, Kousuke Noda, Mari Ebinuma, Shunsuke Kubota, Haruna Koizumi, Satoru Yoshida, Yoko Ozawa, Shigeto Shimmura, Susumu Ishida, Kazuo Tsubota
MOLECULAR VISION, 15, 290, 2751, 2761, 2009年12月, ［査読有り］
英語, 研究論文（学術雑誌）

Dehiscence of levator aponeurosis in ptosis after sub-Tenon injection of triamcinolone acetonide
Shinji Ideta, Mika Noda, Ryosuke Kawamura, Kei Shinoda, Kotaro Suzuki, Susumu Ishida, Makoto Inoue
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE, 44, 6, 668, 672, 2009年12月, ［査読有り］
英語, 研究論文（学術雑誌）

NEW RETRACTOR CAPABLE OF ASPIRATING FLUIDS DURING SCLERAL BUCKLING SURGERY
Toshihide Kurihara, Kotaro Suzuki, Kousuke Noda, Ryosuke Kawamura, Norihiro Nagai, Hajime Shinoda, Kei Shinoda, Kazuo Tsubota, Susumu Ishida, Makoto Inoue
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 29, 10, 1542, 1544, 2009年11月, ［査読有り］
英語

Inflammatory Corneal Neovascularization and Tissue Renin-Angiotensin System
Tomohiko Usui, Susumu Ishida, Shiro Amano
CORNEA, 28, 9, S54, S57, 2009年10月, ［査読有り］
英語, 研究論文（学術雑誌）

Involvement of Hyaluronan and Its Receptor CD44 with Choroidal Neovascularization
Hiroshi Mochimaru, Eri Takahashi, Nobuo Tsukamoto, Junichiro Miyazaki, Tomonori Yaguchi, Takashi Koto, Toshihide Kurihara, Kousuke Noda, Yoko Ozawa, Takatsugu Ishimoto, Yutaka Kawakami, Hidenobu Tanihara, Hideyuki Saya, Susumu Ishida, Kazuo Tsubota
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 50, 9, 4410, 4415, 2009年09月, ［査読有り］
英語, 研究論文（学術雑誌）

Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization
Mochimaru, H, Takahashi, E, Tsukamoto, N, Miyazaki, J, Yaguchi, T, Koto, T, Kurihara, T, Noda, K, Ozawa, Y, Ishimoto, T, Kawakami, Y, Tanihara, H, Saya, H, Ishida, S, Tsubota, K
Invest Ophthalmol Vis Sci, 50, 9, 4410, 5, 2009年09月
PURPOSE: CD44 is a cell-surface adhesion molecule and receptor for hyaluronan (HA), one of the major extracellular matrix components. The purpose of the present study was to clarify a role of HA and CD44 in the development of choroidal neovascularization (CNV). METHODS: Laser photocoagulation was used to induce CNV in C57BL/6 mice or CD44-deficient mice. The mRNA expression of CD44 and HA synthase (HAS)-2 in the retinal pigment epithelium (RPE)-choroid complex was evaluated by DNA microarray and real-time RT-PCR analyses 3 days after laser treatment. HA synthesis and CD44 expression were examined by immunohistochemistry 1 week after photocoagulation. Mice with laser-induced CNV were systemically administered the HA synthesis inhibitor 4-methylumbelliferone (MU) or an anti-CD44-neutralizing antibody. The response of CNV was analyzed by volumetric measurements 1 week after photocoagulation. Macrophage infiltration into CNV lesions was evaluated by real-time RT-PCR for F4/80 3 days after laser-induced injury. RESULTS: The induction of CNV led to a significant increase in expression of CD44 and HAS2 mRNA. HA and CD44 were immunopositive in the CNV lesions. Compared with vehicle treatme

Prevention of Ocular Inflammation in Endotoxin-Induced Uveitis with Resveratrol by Inhibiting Oxidative Damage and Nuclear Factor-kappa B Activation
Shunsuke Kubota, Toshihide Kurihara, Hiroshi Mochimaru, Shingo Satofuka, Kousuke Noda, Yoko Ozawa, Yuichi Oike, Susumu Ishida, Kazuo Tsubota
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 50, 7, 3512, 3519, 2009年07月, ［査読有り］
英語, 研究論文（学術雑誌）

(Pro)renin Receptor-Mediated Signal Transduction and Tissue Renin-Angiotensin System Contribute to Diabetes-Induced Retinal Inflammation
Shingo Satofuka, Atsuhiro Ichihara, Norihiro Nagai, Kousuke Noda, Yoko Ozawa, Akiyoshi Fukamizu, Kazuo Tsubota, Hiroshi Itoh, Yuichi Oike, Susumu Ishida
DIABETES, 58, 7, 1625, 1633, 2009年07月, ［査読有り］
英語, 研究論文（学術雑誌）

Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients
Yukihiro Horie, Nobuyoshi Kitaichi, Yoshihiko Katsuyama, Kazuhiko Yoshida, Toshie Miura, Masao Ota, Yuri Asukata, Hidetoshi Inoko, Nobuhisa Mizuki, Susumu Ishida, Shigeaki Ohno
MOLECULAR VISION, 15, 118, 1115, 1119, 2009年06月, ［査読有り］
英語, 研究論文（学術雑誌）

Secondary macular hole associated with central retinal vein occlusion treated with corticosteroid injection
Manabu Hirasawa, Kousuke Noda, Hajime Shinoda, Yoko Ozawa, Kazuo Tsubota, Susumu Ishida
JAPANESE JOURNAL OF OPHTHALMOLOGY, 53, 3, 279, 281, 2009年05月, ［査読有り］
英語

Neuroprotective Effect of an Antioxidant, Lutein, during Retinal Inflammation
Mariko Sasaki, Yoko Ozawa, Toshihide Kurihara, Kousuke Noda, Yutaka Imamura, Saori Kobayashi, Susumu Ishida, Kazuo Tsubota
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 50, 3, 1433, 1439, 2009年03月, ［査読有り］
英語, 研究論文（学術雑誌）

[Lifestyle-related diseases and anti-aging ophthalmology: suppression of retinal and choroidal pathologies by inhibiting renin-angiotensin system and inflammation].
Ishida S
Nippon Ganka Gakkai zasshi, 113, 3, 403, 22; discussion 423, 2009年03月, ［査読有り］

生活習慣病と眼 生活習慣病と抗加齢眼科学 レニン-アンジオテンシン系と炎症制御による網脈絡膜病態の是正
石田 晋, 永井 紀博, 里深 信吾, 永井 香奈子, 栗原 俊英, 厚東 隆志, 持丸 博史, 久保田 俊介, 野田 航介, 小沢 洋子, 坪田 一男, 市原 淳弘, 伊藤 裕, 岡野 栄之, 須田 年生, 河上 裕, 梅澤 一夫, 尾池 雄一, 深水 昭吉, 大神 一浩, 大野 重昭
日本眼科学会雑誌, 113, 3, 403, 423, (公財)日本眼科学会, 2009年03月
日本語

Serum antioxidants and age-related macular degeneration among older Japanese
Takehiro Michikawa, Susumu Ishida, Yuji Nishiwaki, Yuriko Kikuchi, Tazuru Tsuboi, Kanae Hosoda, Ai Ishigami, Satoko Iwasawa, Makiko Nakano, Toru Takebayashi
Asia Pacific Journal of Clinical Nutrition, 18, 1, 1, 7, 2009年03月, ［査読有り］
中国語, 研究論文（学術雑誌）

Simultaneous use of intravitreal viscoelastics and perfluorocarbon liquid during vitrectomy for severe globe rupture.
Shigeyasu C, Imamura Y, Ishida S, Tsubota K, Inoue M
Retinal cases & brief reports, 3, 3, 305, 307, 2009年, ［査読有り］

慶應義塾大学眼科におけるLASIK術後の網膜剥離・網膜裂孔の検討(第2報)　　　　　　　　　　　　　　　
谷口 沙織, 今村 裕, 内田 敦郎, 川村 亮介, 鈴木 浩太郎, 篠田 肇, 野田 航介, 小沢 洋子, 石田 晋
眼科臨床紀要, 2, 1, 75, 76, 眼科臨床紀要会, 2009年01月
日本語

Gender-specific associations of vision and hearing impairments with adverse health outcomes in older Japanese: A population-based cohort study
Takehiro Michikawa, Yuji Nishiwaki, Yuriko Kikuchi, Makiko Nakano, Satoko Iwasawa, Keiko Asakura, Ai Milojevic, Kunio Mizutari, Hideyuki Saito, Susumu Ishida, Tomonori Okamura, Toru Takebayashi
BMC Geriatrics, 9, 1, 2009年, ［査読有り］
英語, 研究論文（学術雑誌）

Suppression of experimental autoimmune uveitis by angiotensin II type 1 receptor blocker telmisartan
Okunuki Yoko, Usui Yoshihiko, Nagai Norihiro, Kezuka Takeshi, Ishida Susumu, Takeuchi Masaru, Goto Hiroshi
Investigative Ophthalmology and Visual Science, 50, 5, 2255, 2261, 2009年
英語, 研究論文（学術雑誌）, <p>PURPOSE. Angiotensin II type 1 receptor (AT1-R) blockers are used widely for the treatment of patients with hypertension. Recent reports have suggested that AT1-R also plays a key role in various inflammatory conditions. The aim of this study was to examine whether blockade of AT1-R is effective in the suppression of murine experimental autoimmune uveoretinitis (EAU). METHODS. C57BL/6 mice were immunized with human interphotoreceptor retinoid binding protein-derived peptide 1-20 (hIRBP-p). Telmisartan, an AT1-R blocker, was administrated daily by intraperitoneal injection. On day 21 after immunization, the severity of EAU was assessed clinically and histopathologically. With the use of flow cytometry, the activation of draining lymph node (LN) cells was assessed by cell proliferation response against hIRBP-p and by the number of CD44^high activated CD4⁺ T cells present. In addition, mRNA expression of ICAM-1, MCP-1, and IFN-γ in the eye was analyzed by reverse-transcriptase PCR, and the number of retinal adherent leukocytes was counted by retinal perfusion labeling. RESULTS. Telmisartan significantly suppressed EAU clinically and histopathologically. Intrao

(Pro)renin Receptor Promotes Choroidal Neovascularization by Activating Its Signal Transduction and Tissue Renin-Angiotensin System
Shingo Satofuka, Atsuhiro Ichihara, Norihiro Nagai, Kousuke Noda, Yoko Ozawa, Akiyoshi Fukamizu, Kazuo Tsubota, Hiroshi Itoh, Yuichi Oike, Susumu Ishida
AMERICAN JOURNAL OF PATHOLOGY, 173, 6, 1911, 1918, 2008年12月, ［査読有り］
英語, 研究論文（学術雑誌）

Rhegmatogenous retinal detachment associated with primary congenital glaucoma
Satofuka, S, Imamura, Y, Ishida, S, Ozawa, Y, Tsubota, K, Inoue, M
Int Ophthalmol, 28, 5, 369, 71, 2008年10月, ［査読有り］
英語, BACKGROUND: The development of rhegmatogenous retinal detachments (RRDs) in eyes with a history of congenital glaucoma (CG) is very rare. We present the characteristics and surgical outcomes of three cases with a RRD who had CG and had undergone surgery many years earlier. CASES: Three men, ages 14, 43, and 48 years of age, each with a history of surgery for primary CG, presented with a RRD. All of the eyes were highly myopic. The retinal tears were located at the equator in all cases. The degree of RRD were superior half, total, and total (proliferative vitreoretinopathy). OBSERVATIONS: Vitrectomy was performed and the retinas were reattached in all cases. However, the visual acuity in all cases remained poor. CONCLUSIONS: Our findings indicate that a posterior vitreous detachment due to advanced vitreous liquefaction in the highly myopic eyes may have been the cause of the RRD. We recommend periodic fundus examinations in patients with CG, because while the RRD in patients with CG can be reattached the functional recovery may not be good.

Inhibition of corneal neovascularization by blocking the angiotensin II type 1 receptor
永井 紀博
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 49, 10, 4370, 4376, 2008年10月
英語, 研究論文（学術雑誌）

Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation.
Ozawa Y, Nakao K, Kurihara T, Shimazaki T, Shimmura S, Ishida S, Yoshimura A, Tsubota K, Okano H†
The Journal of Biological Chemistry, 283, 36, 24561, 24570, 36, 2008年09月, ［査読有り］

Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina.
Kurihara T, Ozawa Y, Nagai N, Shinoda K, Noda K, Imamura Y, Tsubota K, Okano H, Oike Y, Ishida S†
Diabetes, 57, 2191, 2198, 8, 2008年08月, ［査読有り］

Suprachoroidal hemorrhage caused by breakage of a 25-gauge cannula
Chieh-Jen Chen, Shingo Satofuka, Makoto Inoue, Susumu Ishida, Kei Shinoda, Kazuo Tsubota
OPHTHALMIC SURGERY LASERS & IMAGING, 39, 4, 323, 324, 2008年07月, ［査読有り］
英語, 研究論文（学術雑誌）

Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2
Mochimaru, H, Usui, T, Yaguchi, T, Nagahama, Y, Hasegawa, G, Usui, Y, Shimmura, S, Tsubota, K, Amano, S, Kawakami, Y, Ishida, S
Invest Ophthalmol Vis Sci, 49, 5, 2172, 7, 2008年05月
英語, PURPOSE: To investigate whether the induction of cytotoxic T lymphocytes (CTLs) targeting VEGF receptor 2 inhibits corneal neovascularization caused by alkali injury. METHODS: H-2Db-restricted peptide corresponding to amino acids 400 to 408 of VEGF receptor 2 (VEGFR2(400-408)) was used as an epitope peptide. Dendritic cells (DCs) were harvested from bone marrow progenitors of C57BL/6 mice. Six-week-old C57BL/6 mice received subcutaneous injections of VEGFR2(400-408)- or gp70-pulsed mature DCs three times at 6-day intervals. After the third immunization, corneal neovascularization was induced by alkali injury. Two weeks after the injury, the corneal vascularized area was evaluated by lectin angiography. To confirm the peptide-specific CTL activities in C57BL/6 mice, CD8(+) T cells from immunized mice were subjected to ELISA for interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha production and (51)Cr-release cytotoxicity assay. To determine the in vivo effector T cells, the immunized mice were intraperitoneally injected with an anti-CD4 or -CD8 depletion antibody. RESULTS: Corneal neovascularization was significantly attenuated in mice immunized with VEGFR2(400-408) compare

Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice.
Hashizume K, Hirasawa M, Imamura Y†, Noda S, Shimizu T, Shinoda K, Kurihara T, Noda K, Ozawa Y, Ishida S, Miyake Y, Shirasawa T, Tsubota K
The American Journal of Pathology, 172, 1325, 1331, 5, 2008年05月, ［査読有り］

Vitrectomy combined with glial tissue removal at the optic pit in a patient with optic disc pit maculopathy: A case report
Makoto Inoue, Kei Shinoda, Susumu Ishida
Journal of Medical Case Reports, 2, 2008年04月07日, ［査読有り］
英語, 研究論文（学術雑誌）

アンジオテンシンII1型受容体阻害による糖尿病モデル網膜血管炎症の抑制　　　　　　　　　　　　　　　
永井 紀博, 厚東 隆志, 里深 信吾, 持丸 博史, 小澤 洋子, 坪田 一男, 井上 真, 石田 晋
日本糖尿病眼学会誌, 12, 83, 83, 日本糖尿病眼学会, 2008年04月
日本語

Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin.
Izumi-Nagai K, Nagai N, Ohgami K, Satofuka S, Ozawa Y, Tsubota K, Ohno S, Oike Y, Ishida S
Investigative ophthalmology & visual science, 49, 4, 1679, 1685, 2008年04月, ［査読有り］

マウス脈絡膜新生血管モデルにおけるVAP-1阻害剤の血管新生抑制効果　　　　　　　　　　　　　　　
野田 航介, 吉川 奈美, 里深 信吾, 栗原 俊英, 真島 行彦, 石田 晋
日本眼科学会雑誌, 112, 臨増, 222, 222, (公財)日本眼科学会, 2008年03月
日本語

Jamming of 25-gauge instruments in the cannula during vitrectomy for vitreous haemorrhage
Hajime Shinoda, Takeshi Nakajima, Kei Shinoda, Kotaro Suzuki, Susumu Ishida, Makoto Inoue
ACTA OPHTHALMOLOGICA, 86, 2, 160, 164, 2008年03月, ［査読有り］
英語, 研究論文（学術雑誌）

Visual recovery after vitrectomy for macular hole using 25-gauge instruments
Shinoda, H, Shinoda, K, Satofuka, S, Imamura, Y, Ozawa, Y, Ishida, S, Inoue, M
Acta Ophthalmol, 86, 2, 151, 5, 2008年03月, ［査読有り］
英語, PURPOSE: To determine whether vitrectomy with 25-gauge instruments contributes to better postoperative visual recovery after macular hole (MH) surgery. METHODS: The medical records for 46 consecutive eyes operated for MH by a single surgeon were retrospectively examined. Vitrectomy had been performed with a 25-gauge instrument in 23 eyes (25-G group) and with a 20-gauge instrument in 23 eyes (20-G group). Postoperative visual acuity (VA) in logMAR (logarithm of the minimum angle of resolution) units after 1 week and 1, 3, 6, 9 and 12 months, operating time, and volume of intraocular irrigating fluid were compared between the two groups. RESULTS: Mean preoperative logMAR VA was 0.72 in the 25-G group and 0.68 in the 20-G group (p = 0.282, unpaired t-test). One week after surgery, VA was significantly better in the 25-G group (0.40 +/- 0.34) than in the 20-G group (0.58 +/- 0.30) (p = 0.020). This significant difference was maintained until 9 months after surgery, but was no longer evident at 12 months (p = 0.182). Operating time was significantly shorter in the 25-G group (56 +/- 16 mins) than in the 20-G group (85 +/- 28 mins) (p = 0.003, unpaired t-test). The volume of intraocular

加齢黄斑変性に対する薬物治療の現状および問題点
石田 晋
日本薬理学雑誌, 131, 1, 47, 49, 公益社団法人 日本薬理学会, 2008年01月01日
日本語, 滲出型加齢黄斑変性の中心的病態は，脈絡膜血管新生であり，新生血管の透過性亢進による滲出性変化が神経網膜を恒久的に傷害する．近年の細胞生物学の進歩は，これらの病態における複数の分子メカニズムを明らかにしてきたため，特定の分子を標的とした阻害薬が開発される時代になった．なかでも血管内皮増殖因子（VEGF）は，進行の鍵となる2つの病態，血管新生・血管透過性亢進を促進することが明らかにされ，その阻害薬の臨床応用が実現した．眼科領域で臨床応用されたVEGF阻害薬pegaptanib（Macugen^®），ranibizumab（Lucentis^®），bevacizumab（Avastin^®）は，黄斑浮腫・剥離や血管新生を軽減させ，少なくとも短期的には有効であることがわかった．しかし，至適な投与法，長期の安全性，既存の光線力学療法との併用についてなど，検討すべき課題が山積みされている．

【糖尿病網膜症の最新治療戦略】治療戦略を立てるための病態の細胞生物学的理解
野田 航介, 石田 晋
眼科手術, 21, 1, 5, 9, (公社)日本眼科手術学会, 2008年01月
日本語

Age-related macular degeneration (AMD); From pathogenesis and approved therapies to proposed treatments for prevention　　　　　　　　　　　　　　　
Ozawa, Y, Ishida, S, Tsubota, K
Anti-Aging Medicine, 5, 8, 2008年, ［査読有り］

Pathologic roles of prorenin and (pro)renin receptor in the eye
Satofuka Shingo, Ichihara Atsuhiro, Nagai Norihiro, Tsubota Kazuo, Itoh Hiroshi, Ishida Susumu
Frontiers in Bioscience, 13, 10, 3884, 3895, 2008年
英語, 研究論文（学術雑誌）, <p>Recent reports indicated that tissue renin-angiotensin system (RAS) was upregulated and angiotensin II type 1 receptor signaling plays cmcial roles in ocular inflammation and neovascularization; however, the precise mechanism for activating tissue RAS had not been defined until recently. (Pro)renin receptor, a recently identified molecule existing in the major organs but not in the circulation, has attracted growing attention as an activator of tissue RAS. When the handle region of the prorenin prosegment binds to (pro)renin receptor, prorenin undergoes a conformational change to its enzymatically active state without the conventional proteolysis of the prorenin prosegment. Systemic treatment with a peptide with the structure of the handle region (handle region peptide; HRP), which competitively binds to (pro)renin receptor as a decoy peptide and inhibit the nonproteolytic activation of prorenin, resulted in the suppression of retinal inflammation and neovascularizaion in the rodent models. Retinal expression of RAS-related inflammatory and angiogenic molecules, such as intercellular adhesion molecule-1, monocyte chemotactic protein-1, and vascular endothelial growth factor, was

Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina　　　　　　　　　　　　　　　
岡野 栄之
NEUROSCIENCE RESEARCH, 61, S220, S220, 2008年
英語, 研究論文（学術雑誌）

Surgical effects and complications of indocyanine green-assisted internal limiting membrane peeling for idiopathic macular hole
永井 紀博
ACTA OPHTHALMOLOGICA SCANDINAVICA, 85, 8, 883, 889, 2007年12月
英語, 研究論文（学術雑誌）, PURPOSE:



To compare the surgical outcomes and complications of vitrectomy with internal limiting membrane (ILM) peeling with or without indocyanine green (ICG) staining in eyes with an idiopathic macular hole.



METHODS:



This study involved a non-randomized, single-centre, retrospective, interventional case series. Rates of anatomical closure, visual acuities (VAs) and postoperative complications in 35 eyes of 31 patients who underwent ICG-assisted ILM peeling during macular hole surgery (stained group) were compared with those in 18 eyes of 16 patients who underwent the same procedure without ICG staining (non-stained group).



RESULTS:



Macular holes were closed following the initial surgery in 97% of the stained group and 94% of the non-stained group (p > 0.999). There was no significant difference in mean final VA between the stained and non-stained groups, but there was a lower percentage of eyes with postoperative vision > 20/25 in the stained group (15%) than in the non-stained group (44%) after 2 years (p = 0.036). Posterior retinal pigment epithelium atrophy, retinoschisis and visual field defects were observed only in the stained group.



CONCLUSIONS:



The difference i

Macular pigment lutein is antiinflammatory in preventing choroidal neovascularization.
Izumi-Nagai K, Nagai N, Ohgami K, Satofuka S, Ozawa Y, Tsubota K, Umezawa K, Ohno S, Oike Y, Ishida S
Arteriosclerosis, thrombosis, and vascular biology, 27, 12, 2555, 2562, 2007年12月, ［査読有り］

Two-step oblique incision during 25-gauge vitrectomy reduces incidence of postoperative hypotony
Makoto Inoue, Kei Shinoda, Hajime Shinoda, Ryosuke Kawamura, Kotaro Suzuki, Susumu Ishida
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 35, 8, 693, 696, 2007年11月, ［査読有り］
英語, 研究論文（学術雑誌）

Suppression of choroidal neovascularization by dendritic cell vaccination targeting VEGFR2.
Mochimaru H, Nagai N, Hasegawa G, Kudo-Saito C, Yaguchi T, Usui Y, Kurihara T, Koto T, Satofuka S, Shinoda H, Ozawa Y, Tsubota K, Kawakami Y, Ishida S†
Investigative Ophthalmology & Visual Science, 48, 4795, 4801, 10, 2007年10月, ［査読有り］

レニン・アンジオテンシン系とカリクレイン・キニン系の実験的脈絡膜血管新生への関与　　　　　　　　　　　　　　　
永井 紀博, 永井 香奈子, 厚東 隆志, 里深 信吾, 小澤 洋子, 井上 真, 石田 晋
眼科臨床医報, 101, 9, 946, 946, 眼科臨床医報会, 2007年09月
日本語

エイコサペンタエン酸の摂取による実験的脈絡膜血管新生の抑制効果　　　　　　　　　　　　　　　
厚東 隆志, 永井 紀博, 篠田 肇, 里深 信吾, 栗原 俊英, 小澤 洋子, 井上 真, 石田 晋
眼科臨床医報, 101, 9, 946, 946, 眼科臨床医報会, 2007年09月
日本語

プロレニンの非タンパク融解的活性化の阻害による網膜血管新生の抑制　　　　　　　　　　　　　　　
里深 信吾, 永井 紀博, 厚東 隆志, 小澤 洋子, 井上 真, 石田 晋
眼科臨床医報, 101, 9, 946, 947, 眼科臨床医報会, 2007年09月
日本語

Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway.
Nagai N, Izumi-Nagai K, Oike Y, Koto T, Satofuka S, Ozawa Y, Yamashiro K, Inoue M, Tsubota K, Umezawa K, Ishida S
Investigative ophthalmology & visual science, 48, 9, 4342, 4350, 2007年09月, ［査読有り］

Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in mice.
Koto T, Nagai N, Mochimaru H, Kurihara T, Izumi-Nagai K, Satofuka S, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Oike Y, Ishida S†
Investigative Ophthalmology & Visual Science, 48, 4328, 4334, 9, 2007年09月, ［査読有り］

25-Gauge cannula system with microvitreoretinal blade trocar
Makoto Inoue, Kei Shinoda, Hajime Shinoda, Kotaro Suzuki, Ryosuke Kawamura, Susumu Ishida
AMERICAN JOURNAL OF OPHTHALMOLOGY, 144, 2, 302, 304, 2007年08月, ［査読有り］
英語, 研究論文（学術雑誌）

Patients' descriptions of visual sensations during pars plana vitrectomy under retrobulbar anesthesia
Sugisaka, E, Shinoda, K, Ishida, S, Imamura, Y, Ozawa, Y, Shinoda, H, Suzuki, K, Tsubota, K, Inoue, M
Am J Ophthalmol, 144, 2, 245, 51, 2007年08月, ［査読有り］
英語, PURPOSE: To investigate the visual sensations experienced by patients during vitrectomy under retrobulbar anesthesia. DESIGN: Cross-sectional study. METHODS: Fifty-six men and 45 women with a mean age of 62.2 +/- 11.9 years (range, 30 to 89 years) were studied. Twenty-two eyes had an idiopathic epiretinal membrane, 10 had an idiopathic macular hole, 29 had macular edema (16 resulting from diabetic retinopathy and 13 resulting from retinal vein occlusion), 14 had proliferative diabetic retinopathy, 13 had rhegmatogenous retinal detachment, four had proliferative vitreoretinopathy, and nine had other retinal diseases. The patients were questioned about their visual sensations during and within three hours after vitrectomy, which was performed under retrobulbar anesthesia using 2% lidocaine hydrochloride. Visual sensations perceived by the patients during surgery were reviewed. RESULTS: Ninety-one of the 101 patients experienced some type of visual sensation during the vitrectomy. Ninety-one (90.1%) patients reported seeing lights, 73 (72.3%) patients reported seeing one or more colors, and 57 (56.4%) patients reported seeing movements or moving objects. Of these latter 57 patients, 5

Binding of ADAM28 to p-selectin glycoprotein ligand-1 enhances p-selectin-mediated leukocyte adhesion to endothelial cells
永井 紀博
JOURNAL OF BIOLOGICAL CHEMISTRY, 282, 35, 25864, 25874, 2007年08月
英語, 研究論文（学術雑誌）

炎症細胞の血管外遊走におけるADAM28の役割　　　　　　　　　　　　　　　
下田 将之, 橋本 学爾, 望月 早月, 池田 栄二, 永井 紀博, 石田 晋, 岡田 保典
Inflammation and Regeneration, 27, 4, 423, 423, (一社)日本炎症・再生医学会, 2007年07月
日本語

Intraoperative dehiscence of laser subepithelial keratomileusis (LASEK) flap during retinal detachment surgery.
Kawamura R, Noda K, Negishi K, Shinoda K, Ishida S, Inoue M, Tsubota K
Acta ophthalmologica Scandinavica, 85, 4, 459, 4, 2007年06月, ［査読有り］

Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization.
Izumi-Nagai K, Nagai N, Ozawa Y, Mihara M, Ohsugi Y, Kurihara T, Koto T, Satofuka S, Inoue M, Tsubota K, Okano H, Oike Y, Ishida S†
The American Journal of Pathology, 170, 2149, 2158, 6, 2007年06月, ［査読有り］

Cardiac output increases the rate of carbon monoxide elimination in hyperpneic but not normally ventilated dogs
Susumu Ishida, Akinori Takeuchi, Takafumi Azami, Kazuya Sobue, Hiroshi Sasano, Hirotada Katsuya, Joseph A. Fisher
Journal of Anesthesia, 21, 2, 181, 186, 2007年05月, ［査読有り］
英語, 研究論文（学術雑誌）

Suppression of choroidal neovascularization by inhibiting angiotensin-converting enzyme: minimal role of bradykinin.
Nagai N, Oike Y, Izumi-Nagai K, Koto T, Satofuka S, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Ishida S
Investigative ophthalmology & visual science, 48, 5, 2321, 2326, 2007年05月, ［査読有り］

Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells.
Koto T, Takubo K, Ishida S, Shinoda H, Inoue M, Tsubota K, Okada Y, Ikeda E
The American journal of pathology, 170, 4, 1389, 1397, 4, 2007年04月, ［査読有り］

プロレニン受容体の阻害による脈絡膜血管新生の抑制　　　　　　　　　　　　　　　
里深 信吾, 市原 淳弘, 永井 紀博, 厚東 隆志, 小沢 洋子, 井上 真, 伊藤 裕, 坪田 一男, 石田 晋
日本眼科学会雑誌, 111, 臨増, 266, 266, (公財)日本眼科学会, 2007年03月
日本語

眼と加齢 活性酸素・炎症 エイジング仮説
坪田 一男, 今村 裕, 藤島 浩, 根岸 一乃, 井上 真, 榛村 重人, 石田 晋, 村戸 ドール, 小沢 洋子, 木村 至, 出田 真二, 結城 賢弥, 橋爪 公平, 永井 紀博, 里深 信吾, 平沢 学, 小川 由佳子, 栗原 俊英, 厚東 隆志, 深川 和己, 樋口 明弘, 海道 美奈子, 石田 玲子, 篠田 啓, 加藤 直子, 小川 葉子, 佐伯 めぐみ, 斎藤 一郎, 美島 健二, 井上 裕子, 後藤 英樹, 野田 節子, 水島 裕, 白澤 卓二, 清水 孝彦, 山口 美峰子, 内山 智, 吉田 悟, 比嘉 一成, 川北 哲也, 佐竹 良之, 田 聖花, 富田 真智子, 島崎 潤, 戸田 郁子, 堀 好子, 酒井 誓子, 河上 裕, 竹内 勤, 中村 滋, 渋谷 倫子, 中嶋 英雄, 久村 隆二, 増田 望, 佐々木 恭平
日本眼科学会雑誌, 111, 3, 193, 206, (公財)日本眼科学会, 2007年03月
日本語

SOCS3 is required to temporally fine-tune photoreceptor cell differentiation.
Ozawa Y, Nakao K, Shimazaki T, Shimmura S, Kurihara T, Ishida S, Yoshimura A, Tsubota K, Okano H†
Developmental Biology, 303, 2, 591, 600, 2, 2007年03月, ［査読有り］

Detecting vitreomacular adhesions in eyes with asteroid hyalosis with triamcinolone acetonide
Takefumi Yamaguchi, Makoto Inoue, Susumu Ishida, Kei Shinoda
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 245, 2, 305, 308, 2007年02月, ［査読有り］
英語, 研究論文（学術雑誌）

Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization.
Satofuka S, Ichihara A, Nagai N, Koto T, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Itoh H, Oike Y, Ishida S
Investigative ophthalmology & visual science, 48, 1, 422, 429, 2007年01月, ［査読有り］

Neuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation.
Kurihara T, Ozawa Y, Shinoda K, Nagai N, Inoue M, Oike Y, Tsubota K, Ishida S, Okano H†
Investigative Ophthalmology & Visual Science, 47, 5545, 5552, 12, 2006年12月, ［査読有り］

Current concept of the pathogenesis of age-related macular degeneration : the role of oxidative stress and inflammation
Imamura Yutaka, Ishida Susumu, Tsubota Kazuo
炎症・再生 : 日本炎症・再生医学会雑誌 = Inflammation and regeneration, 26, 6, 492, 500, 日本炎症・再生医学会, 2006年11月25日
英語, Age-related macular degeneration (AMD) is a common disorder in the aged people that affects the central region of the retina, which is called macula. AMD is the leading cause of legal blindness in people older than 65 in the developed world. AMD is characterized by very typical retinal pathologies including drusen, retinal pigment epithelium dysfunction, retinal degeneration (geographic atrophy) and choroidal neovascu-larization. Recent studies reveal that oxidative stress and inflammation are significantly linked to the pathogenesis of AMD. Retina is especially susceptible to oxidative stress by following reasons: 1) photoreceptors contain polyunsaturated fatty acids, 2) retina is exposed continuously to light, 3) its oxygen consumption is high, 4) it contains chromopheres which react with light and produce reactive oxygen species (ROS). Moreover, ran-domized, prospective, placebo-controlled study in United States showed that high-dose supplementation of beta-caroten, vitamin C, vitamin E, copper, and zinc significantly slowed the progression of the disease and visual deterioration in patients with AMD. Mice deficient of Cu, Zn-superoxide dismutase showed typical features of human AMD, suggesting that oxidative stress scavenger may play a critical role in the prevention of age-related retinal degeneration. Obesity and inflammatory biomarkers are significantly associated with the risk of AMD, which possibly indicates that AMD is considered as a consequence of disturbance of homeo-stasis, such as metabolic syndrome. Recent genetic studies showed genes related to immune system via complement are associated with AMD, which revealed that inflammatory reactions are causally linked with the pathogenesis of AMD. Recently, the inhibitor of angiotensin II type 1 receptor reduced the volume of experimental CNV after laser burn, suggesting that angiotensin II type 1 receptor blockade be a novel therapeutic strategy as a preventive treatment for AMD. Further research is necessary to invent mechanism-based therapies forAMD.

アンジオテンシンII1型受容体阻害による脈絡膜新生血管の抑制　　　　　　　　　　　　　　　
永井 紀博, 里深 信吾, 厚東 隆志, 篠田 肇, 栗原 俊英, 小沢 洋子, 井上 真, 石田 晋
眼科臨床医報, 100, 10, 808, 808, 眼科臨床医報会, 2006年10月
日本語

Visual Sensations during Vitrectomy
Sugisaka, E, Shinoda, K, Ishida, S, Imamura, Y, Ozawa, Y, Nakajima, T, Shinoda, H, Suzuki, K, Kawaguchi, N, Inoue, M
Ophthalmology, 113, 10, 1886.e1, 2, 2006年10月, ［査読有り］
英語

Angiotensin II type 1 receptor-mediated inflammation is required for choroidal neovascularization.
Nagai N, Oike Y, Izumi-Nagai K, Urano T, Kubota Y, Noda K, Ozawa Y, Inoue M, Tsubota K, Suda T, Ishida S
Arteriosclerosis, thrombosis, and vascular biology, 26, 10, 2252, 2259, 2006年10月, ［査読有り］

Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin.
Satofuka S, Ichihara A, Nagai N, Yamashiro K, Koto T, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Suzuki F, Oike Y, Ishida S
Investigative ophthalmology & visual science, 47, 6, 2686, 2692, 2006年06月, ［査読有り］

Angiotensin II 1型受容体阻害による抗炎症を介した脈絡膜新生血管の抑制　　　　　　　　　　　　　　　
永井 紀博, 尾池 雄一, 永井 香奈子, 里深 信吾, 厚東 隆志, 小澤 洋子, 坪田 一男, 石田 晋
日本抗加齢医学会総会プログラム・抄録集, 6回, 139, 139, (一社)日本抗加齢医学会, 2006年05月
日本語

脈絡膜血管新生の抑制へのω-3脂肪酸の影響(Effects of ω-3 Fatty Acid on Suppression of Choroidal Neovascularization)　　　　　　　　　　　　　　　
厚東 隆志, 永井 紀博, 小澤 洋子, 井上 真, 坪田 一男, 石田 晋
日本抗加齢医学会総会プログラム・抄録集, 6回, 148, 148, (一社)日本抗加齢医学会, 2006年05月
日本語

アンジオテンシンII1型受容体拮抗薬による脈絡膜新生血管の抑制　　　　　　　　　　　　　　　
永井 紀博, 里深 信吾, 厚東 隆志, 篠田 肇, 栗原 俊英, 小澤 洋子, 井上 真, 坪田 一男, 石田 晋
日本眼科学会雑誌, 110, 臨増, 198, 198, (公財)日本眼科学会, 2006年03月
日本語

【糖尿病眼合併症の診療指針】Basic 網膜新生血管の硝子体内侵入と間質分解酵素MMP　　　　　　　　　　　　　　　
野田 航介, 石田 晋
眼科プラクティス, 7, 245, 247, (株)文光堂, 2006年01月
日本語

Genomic structure and promoter activity of the E1AF gene, a member of the ETS oncogene family.
Ishida S, Higashino F, Aoyagi M, Takahashi A, Suzuki T, Shindoh M, Fujinaga K, Yoshida K
Biochemical and biophysical research communications, 339, 1, 325, 330, 1, 2006年01月, ［査読有り］

アンギオテンシンII1型レセプターのブロックによる炎症を介した網膜血管新生抑制　　　　　　　　　　　　　　　
永井 紀博, 野田 航介, 篠田 肇, 厚東 隆志, 篠田 啓, 井上 真, 石田 晋
眼科臨床医報, 99, 11, 905, 905, 眼科臨床医報会, 2005年11月
日本語

網膜静脈分枝閉塞症に伴う黄斑浮腫へのトリアムシノロンのテノン嚢下投与の有効性
寺内 直毅, 永井 紀博, 篠田 肇, 野田 航介, 今村 裕, 石田 晋, 井上 真
眼科, 47, 12, 1847, 1852, 金原出版(株), 2005年11月
日本語, 黄斑浮腫を伴った網膜静脈分枝閉塞症に対し,トリアムシノロン(TA)のテノン嚢下注射を行って有効性を検討した.対象は網膜光凝固未施行の18例19眼で,最終的な後部硝子体剥離(PVD)の有無によってPVD+群7眼とPVD-群12眼に分け,TA注入前後の中心窩網膜厚を光干渉断層計によって測定した.更に視力の推移を比較した.1)中心窩網膜厚はPVD+群がPVD-群よりも有意に減少し,視力は2段階以上向上して,全例で0.8以上となった.PVD-群では5眼で視力向上した.2)経過中PVDが生じた1眼と,側副血行路が発育したPVD-群の2眼は,中心窩網膜厚が減少し,視力も向上した.3)PVD-群の4眼では視力が悪化したため再度TAを注入したが,2眼で浮腫の改善や視力の向上が認められず,硝子体手術を施行した.4)PVD-群では,注入後3ヵ月以上経過してもPVD発生や側副血行路の発育による黄斑浮腫の軽減が期待できない場合は,TA再注入か硝子体手術を適応とすべきである

Intraocular lens implantation after atopic cataract surgery decreases incidence of postoperative retinal detachment
Makoto Inoue, Kei Shinoda, Susumu Ishida, Atsuro Uchida, Daijiro Kurosaka, Hiroshi Katsura, Kazuo Tsubota
Ophthalmology, 112, 10, 1719, 1724, 2005年10月, ［査読有り］
英語, 研究論文（学術雑誌）

Hypoxia induces the expression of membrane-type 1 matrix metalloproteinase in retinal glial cells.
Noda K, Ishida S, Shinoda H, Koto T, Aoki T, Tsubota K, Oguchi Y, Okada Y, Ikeda E
Investigative ophthalmology & visual science, 46, 10, 3817, 3824, 10, 2005年10月, ［査読有り］

Suppression of ocular inflammation in endotoxin-induced uveitis by blocking the angiotensin II type 1 receptor.
Nagai N, Oike Y, Noda K, Urano T, Kubota Y, Ozawa Y, Shinoda H, Koto T, Shinoda K, Inoue M, Tsubota K, Yamashiro K, Suda T, Ishida S
Investigative ophthalmology & visual science, 46, 8, 2925, 2931, 2005年08月, ［査読有り］

アンギオテンシンII1型受容体阻害による抗炎症作用を介した網膜血管新生抑制
里深 信吾, 永井 紀博, 篠田 肇, 厚東 隆志, 篠田 啓, 井上 真, 坪田 一男, 石田 晋
炎症・再生, 25, 4, 333, 333, (一社)日本炎症・再生医学会, 2005年07月
日本語

アンジオテンシンII1型受容体阻害による脈絡膜新生血管新生の抑制
永井 紀博, 厚東 隆志, 里深 信吾, 小沢 洋子, 石田 晋, 坪田 一男
炎症・再生, 25, 4, 334, 334, (一社)日本炎症・再生医学会, 2005年07月
日本語

アンギオテンシンII1型受容体阻害による眼内炎症の抑制
厚東 隆志, 永井 紀博, 里深 信吾, 小沢 洋子, 篠田 啓, 井上 真, 石田 晋, 坪田 一男
炎症・再生, 25, 4, 355, 355, (一社)日本炎症・再生医学会, 2005年07月
日本語

Adherence of intravitreally injected triamcinolone acetonide to the denuded retinal surface after internal limiting membrane peeling
Shingo Satofuka, Makoto Inoue, Kei Shinoda, Susumu Ishida, Yutaka Imamura, Yasutaka Ando
Retina, 25, 5, 672, 673, 2005年07月, ［査読有り］
英語, 研究論文（学術雑誌）

Pars plana vitrectomy with internal limiting membrane removal for macular hole associated with proliferative diabetic retinopathy.
Kurihara T, Noda K, Ishida S, Inoue M†
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 243, 724, 726, 7, 2005年07月, ［査読有り］

炎症抑制による加齢黄斑変性の新しい治療法の開発　　　　　　　　　　　　　　　
石田 晋, 永井 紀博, 篠田 肇, 厚東 隆志, 坪田 一男
日本抗加齢医学会総会プログラム・抄録集, 5回, 92, 92, (一社)日本抗加齢医学会, 2005年06月
日本語

低酸素濃度環境下における血管内皮細胞barrier機能の破綻　　　　　　　　　　　　　　　
池田 栄二, 厚東 隆志, 石田 晋, 篠田 肇, 井上 真, 坪田 一男, 岡田 保典
日本病理学会会誌, 94, 1, 213, 213, (一社)日本病理学会, 2005年03月
日本語

Selective suppression of pathologic, but not physiologic, retinal neovascularization by blocking the angiotensin II type 1 receptor.
Nagai N, Noda K, Urano T, Kubota Y, Shinoda H, Koto T, Shinoda K, Inoue M, Shiomi T, Ikeda E, Tsubota K, Suda T, Oike Y, Ishida S
Investigative ophthalmology & visual science, 46, 3, 1078, 1084, 2005年03月, ［査読有り］

低酸素下の血管内皮細胞におけるclaudin-5発現動態と血液網膜関門破綻機構の解明　　　　　　　　　　　　　　　
厚東 隆志, 石田 晋, 篠田 肇, 井上 真, 坪田 一男, 岡田 保典, 池田 栄二
日本眼科学会雑誌, 109, 臨増, 146, 146, (公財)日本眼科学会, 2005年02月
日本語

アンギオテンシンII1型レセプターのブロックによる眼内炎症の抑制　　　　　　　　　　　　　　　
永井 紀博, 篠田 肇, 厚東 隆志, 小沢 洋子, 篠田 啓, 井上 真, 坪田 一男, 山城 健児, 石田 晋
日本眼科学会雑誌, 109, 臨増, 184, 184, (公財)日本眼科学会, 2005年02月
日本語

アンギオテンシンII 1型レセプター阻害による抗炎症作用を介した網膜血管新生抑制　　　　　　　　　　　　　　　
石田 晋, 永井 紀博, 野田 航介, 篠田 肇, 厚東 隆志, 篠田 啓, 井上 真, 坪田 一男
日本眼科学会雑誌, 109, 臨増, 212, 212, (公財)日本眼科学会, 2005年02月
日本語

外傷性黄斑円孔に対する硝子体手術　　　　　　　　　　　　　　　
小森 景子, 野田 航介, 永井 紀博, 今村 裕, 石田 晋, 井上 真
眼科臨床医報, 99, 1, 8, 12, 眼科臨床医報会, 2005年01月
日本語

DORC社製25Gシステムの使用経験　　　　　　　　　　　　　　　
井上 真, 里深 信吾, 永井 紀博, 野田 航介, 今村 裕, 篠田 啓, 石田 晋
眼科臨床医報, 99, 1, 65, 65, 眼科臨床医報会, 2005年01月
日本語

【硝子体における眼疾患の病態】眼内血管新生　　　　　　　　　　　　　　　
石田 晋, 野田 航介
眼科, 46, 13, 1851, 1855, 金原出版(株), 2004年12月
日本語

Treatment of retinal detachment after macular translocation with scleral infolding: preservation of macular translocation.
Inoue M, Shinoda K, Ishida S, Shinoda H, Nagai N, Noda K, Oguchi Y
Retina (Philadelphia, Pa.), 24, 6, 962, 964, 6, 2004年12月, ［査読有り］

脈絡膜新生血管に対する黄斑下手術の術後成績　　　　　　　　　　　　　　　
川村 亮介, 永井 紀博, 野田 航介, 今村 裕, 石田 晋, 井上 真
眼科臨床医報, 98, 11, 1034, 1034, 眼科臨床医報会, 2004年11月
日本語

外傷性黄斑円孔に対する硝子体手術　　　　　　　　　　　　　　　
小森 景子, 野田 航介, 永井 紀博, 今村 裕, 石田 晋, 井上 真
眼科臨床医報, 98, 11, 1035, 1035, 眼科臨床医報会, 2004年11月
日本語

増殖糖尿病網膜症に併発した黄斑円孔に対する内境界膜剥離　　　　　　　　　　　　　　　
栗原 俊英, 野田 航介, 永井 紀博, 今村 裕, 石田 晋, 井上 真
眼科臨床医報, 98, 11, 1047, 1047, 眼科臨床医報会, 2004年11月
日本語

Intraoperative breakage of a 25-gauge vitreous cutter.
Inoue M, Noda K, Ishida S, Nagai N, Imamura Y, Oguchi Y
American journal of ophthalmology, 138, 5, 867, 869, 5, 2004年11月, ［査読有り］

A clinicopathologic case report on macular hole associated with von Hippel-Lindau disease: a novel ultrastructural finding of wormlike, wavy tangles of filaments.
Inoue M, Yamazaki K, Shinoda K, Ishida S, Shinoda H, Noda K, Oguchi Y
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 242, 10, 881, 886, 10, 2004年10月, ［査読有り］

脈絡膜新生血管に対する黄斑下手術成績
川村 亮介, 永井 紀博, 野田 航介, 今村 裕, 石田 晋, 井上 真
眼科, 46, 8, 1069, 1076, 金原出版(株), 2004年08月
日本語, 加齢性黄斑変性(ARMD)15例16眼とポリープ様脈絡膜血管症(PCV)5例5眼を対象に,脈絡膜新生血管(CNV)抜去術併用硝子体切除術を施行し,CNVを中心窩下,傍中心窩,中心窩外に分けて術前後視力を比較した.ARMDの中心窩下CNV7眼では,改善43%,不変14%,悪化43%であり,傍中心窩CNV5眼では,改善60%,悪化40%で,中心窩外CNV4眼では,改善75%,不変25%であった.PCV5眼においてCNVは3眼が中心窩下,2眼が傍中心窩に存在し,改善80%,不変20%であった.黄斑下手術は,ARMDの中心窩外,傍中心窩CNVに有効で,PCVではCNVの位置にかかわらず有効であった.また,ARMDによる中心窩下CNVの術後視力が不良であったが,原因は中心窩下に生じた網膜色素上皮欠損と術中に生じた黄斑円孔の発生が考えられた

Successful treatment of subfoveal choroidal neovascularization associated with combined hamartoma of the retina and retinal pigment epithelium.
Inoue M, Noda K, Ishida S, Yamaguchi T, Nagai N, Shinoda K, Shinoda H, Oguchi Y
American journal of ophthalmology, 138, 155, 156, 1, 2004年07月, ［査読有り］

Treatment of cystoid macular edema with oral acetazolamide in a patient with best vitelliform macular dystrophy
Kuniko Hori, Susumu Ishida, Makoto Inoue, Kei Shinoda, Shinichi Kawashima, Shizuaki Kitamura, Yoshihisa Oguchi
Retina, 24, 3, 481, 482, 2004年06月, ［査読有り］
英語, 研究論文（学術雑誌）

糖尿病網膜症の眼内血管新生病変形成における網膜虚血状態の関与　　　　　　　　　　　　　　　
池田 栄二, 野田 航介, 石田 晋, 篠田 肇, 厚東 隆志, 小口 芳久, 岡田 保典
日本病理学会会誌, 93, 1, 247, 247, (一社)日本病理学会, 2004年05月
日本語

VEGF164(165) as the Pathological Isoform: Differential Leukocyte and Endothelial Responses through VEGFR1 and VEGFR2
Tomohiko Usui, Susumu Ishida, Kenji Yamashiro, Yuichi Kaji, Vasiliki Poulaki, Johnny Moore, Tara Moore, Shiro Amano, Yoshitaka Horikawa, Darlene Dartt, Matthew Golding, David T. Shima, Anthony P. Adamis
Investigative Ophthalmology and Visual Science, 45, 2, 368, 374, 2004年02月, ［査読有り］
英語, 研究論文（学術雑誌）

Cerebral fat embolism diagnosed by magnetic resonance imaging at one, eight, and 50 days after hip arthroplasty: A case report
Nobuko Sasano, Susumu Ishida, Shinichiro Tetsu, Hiroe Takasu, Kiyoshi Ishikawa, Hiroshi Sasano, Hirotada Katsuya
Canadian Journal of Anesthesia, 51, 9, 875, 879, Canadian Anaesthetists' Society, 2004年, ［査読有り］
英語, 研究論文（学術雑誌）

Novel 473-bp deletion in XLRS1 gene in a Japanese family with X-linked juvenile retinoschisis
Kei Shinoda, Hisao Ohde, Susumu Ishida, Makoto Inoue, Yoshihisa Oguchi, Yukihiko Mashima
Graefe's Archive for Clinical and Experimental Ophthalmology, 242, 7, 561, 565, Springer Verlag, 2004年, ［査読有り］
英語, 研究論文（学術雑誌）

Retinal blood flow in the macular area before and after scleral buckling procedures for rhegmatogenous retinal detachment without macular involvement
Tadahiko Eshita, Kei Shinoda, Itaru Kimura, Shizuaki Kitamura, Susumu Ishida, Makoto Inoue, Yukihiko Mashima, Hiroshi Katsura, Yoshihisa Oguchi
Japanese Journal of Ophthalmology, 48, 4, 358, 363, Springer Japan, 2004年, ［査読有り］
英語, 研究論文（学術雑誌）

黄斑前膜に対するminimal vitrectomy　　　　　　　　　　　　　　　
井上 真, 永井紀博, 野田航介, 今村 裕, 石田 晋, 篠田 啓, 小口芳久
眼科, 46, 4, 449-453, 2004年
日本語, 研究論文（学術雑誌）

VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization
Susumu Ishida, Tomohiko Usui, Kenji Yamashiro, Yuichi Kaji, Shiro Amano, Yuichiro Ogura, Tetsuo Hida, Yoshihisa Oguchi, Jayakrishna Ambati, Joan W. Miller, Evangelos S. Gragoudas, Yin-Shan Ng, Patricia A. D'Amore, David T. Shima, Anthony P. Adamis
Journal of Experimental Medicine, 198, 3, 483, 489, 2003年08月04日, ［査読有り］
英語, 研究論文（学術雑誌）

Platelets accumulate in the diabetic retinal vasculature following endothelial death and suppress blood-retinal barrier breakdown
Kenji Yamashiro, Akitaka Tsujikawa, Susumu Ishida, Tomohiko Usui, Yuichi Kaji, Yoshihito Honda, Yuichiro Ogura, Anthony P. Adamis
American Journal of Pathology, 163, 1, 253, 259, American Society for Investigative Pathology Inc., 2003年07月01日, ［査読有り］
英語, 研究論文（学術雑誌）

Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease
Susumu Ishida, Kenji Yamashiro, Tomohiko Usui, Yuichi Kaji, Yuichiro Ogura, Tetsuo Hida, Yoshihito Honda, Yoshihisa Oguchi, Anthony P. Adamis
Nature Medicine, 9, 6, 781, 788, 2003年06月01日, ［査読有り］
英語, 研究論文（学術雑誌）

VEGF164 is proinflammatory in the diabetic retina
Susumu Ishida, Tomohiko Usui, Kenji Yamashiro, Yuichi Kaji, Ednan Ahmed, Karen G. Carrasquillo, Shiro Amano, Tetsuo Hida, Yoshihisa Oguchi, Anthony P. Adamis
Investigative Ophthalmology and Visual Science, 44, 5, 2155, 2162, 2003年05月01日, ［査読有り］
英語, 研究論文（学術雑誌）

Production and activation of matrix metalloproteinase-2 in proliferative diabetic retinopathy.
Noda K, Ishida S, Inoue M, Obata K, Oguchi Y, Okada Y, Ikeda E
Investigative ophthalmology & visual science, 44, 5, 2163, 2170, 2003年05月, ［査読有り］

増殖糖尿病網膜症における硝子体液中のmatrix metalloproteinaseについての検討　　　　　　　　　　　　　　　
野田 航介, 池田 栄二, 石田 晋, 井上 真, 小幡 賢一, 岡田 保典, 小口 芳久
日本眼科学会雑誌, 107, 臨増, 212, 212, (公財)日本眼科学会, 2003年03月
日本語

Expression and function of receptors for advanced glycation end products in bovine corneal endothelial cells
Yuichi Kaji, Shiro Amano, Tomohiko Usui, Tetsuro Oshika, Kenji Yamashiro, Susumu Ishida, Kaori Suzuki, Sumiyoshi Tanaka, Anthony P. Adamis, Ryoji Nagai, Seiko Horiuchi
Investigative Ophthalmology and Visual Science, 44, 2, 521, 528, 2003年02月01日, ［査読有り］
英語, 研究論文（学術雑誌）

Indocyanine green can distinguish posterior vitreous cortex from internal limiting membrane during vitrectomy with removal of epiretinal membrane
Tadahiko Eshita, Susumu Ishida, Kei Shinoda, Shizuaki Kitamura, Makoto Inoue, Yoshihisa Oguchi, Kazuto Yamazaki
Retina, 22, 1, 104, 106, 2002年02月, ［査読有り］
英語, 研究論文（学術雑誌）

ON-pathway disturbance in two siblings
Kei Shinoda, Hisao Ohde, Rikako Inoue, Susumu Ishida, Yukihiko Mashima, Yoshihisa Oguchi
Acta Ophthalmologica Scandinavica, 80, 2, 219, 223, 2002年, ［査読有り］
英語, 研究論文（学術雑誌）

Posterior synechia of the iris after combined pars plana vitrectomy, phacoemulsification, and intraocular lens implantation
Kei Shinoda, Aya O'hira, Susumu Ishida, Mika Hoshide, Liliana Sayuri Ogawa, Yoko Ozawa, Kenichi Nagasaki, Makoto Inoue, Hiroshi Katsura
Japanese Journal of Ophthalmology, 45, 3, 276, 280, 2001年05月, ［査読有り］
英語, 研究論文（学術雑誌）

Microcirculation in the macular area of eyes with an idiopathic epiretinal membrane
K. Shinoda, I. Kimura, T. Eshita, S. Kitamura, M. Inoue, S. Ishida, H. Katsura, Y. Mashima
Graefe's Archive for Clinical and Experimental Ophthalmology, 239, 12, 941, 945, Springer Verlag, 2001年, ［査読有り］
英語, 研究論文（学術雑誌）

A new method for quantification of metamorphopsia in patients with epiretinal membrane
Kei Shinoda, Susumu Ishida, Shinichi Kawashima, Tadayuki Matsuzaki, Kyoko Yamada, Hiroshi Katsura
Japanese Journal of Ophthalmology, 44, 4, 424, 427, 2000年07月, ［査読有り］
英語, 研究論文（学術雑誌）

Macular hole retinal detachment in highly myopic eyes: Ultrastructure of surgically removed epiretinal membrane and clinicopathologic correlation
Susumu Ishida, Kazuto Yamazaki, Kei Shinoda, Shinichi Kawashima, Yoshihisa Oguchi
Retina, 20, 2, 176, 183, Lippincott Williams and Wilkins, 2000年, ［査読有り］
英語, 研究論文（学術雑誌）

Clinical factors related to the aqueous levels of vascular endothelial growth factor and hepatocyte growth factor in proliferative diabetic retinopathy
K. Shinoda, S. Ishida, S. Kawashima, T. Wakabayashi, M. Uchita, T. Matsuzaki, M. Takayama, K. Shinmura, M. Yamada
Current Eye Research, 21, 2, 655, 661, Swets en Zeitlinger B.V., 2000年, ［査読有り］
英語, 研究論文（学術雑誌）

Coexpression of VEGF receptors VEGF-R2 and neuropilin-1 in proliferative diabetic retinopathy
Susumu Ishida, Kei Shinoda, Shinichi Kawashima, Yoshihisa Oguchi, Yasunori Okada, Eiji Ikeda
Investigative Ophthalmology and Visual Science, 41, 7, 1649, 1656, 2000年, ［査読有り］
研究論文（学術雑誌）

A new technique for separation of posterior vitreous in vitreous surgery
Kei Shinoda, Makoto Inoue, Hiroshi Katsura, Susumu Ishida
Ophthalmic Surgery and Lasers, 30, 7, 588, 590, 1999年07月, ［査読有り］
英語, 研究論文（学術雑誌）

Severe juvenile retinoschisis associated with a 33-bps deletion in XLRS1 gene
Kei Shinoda, Yukihiko Mashima, Susumu Ishida, Yoshihisa Oguchi
Ophthalmic Genetics, 20, 1, 57, 61, 1999年, ［査読有り］
英語, 研究論文（学術雑誌）

Comparison of the levels of hepatocyte growth factor and vascular endothelial growth factor in aqueous fluid and serum with grades of retinopathy in patients with diabetes mellitus
Kei Shinoda, Susumu Ishida, Shinichi Kawashima, Toshiko Wakabayashi, Tadayuki Matsuzaki, Michiyo Takayama, Ken Shinmura, Masakazu Yamada
British Journal of Ophthalmology, 83, 7, 834, 837, BMJ Publishing Group, 1999年, ［査読有り］
英語, 研究論文（学術雑誌）

増殖糖尿病網膜症手術におけるHydrodelamination　　　　　　　　　　　　　　　
篠田啓, 井上真, 石田晋, 小沢洋子, 小川さゆりリリアーナ, 長崎健一, 桂弘
眼科臨床医報, 92, 11, 1573-1576, 1998年11月
日本語, 研究論文（学術雑誌）

中心性漿液性脈絡網膜症眼と正常眼における黄斑部脈絡膜血管管腔と間質液の体積の比較
三田村瑞穂, 齋藤理幸, 廣岡季里子, 山下結衣, 董震宇, 安藤亮, 加瀬諭, 石田晋, 日本眼科学会雑誌, 129, 2025年

Vogt-小柳-原田病における脳脊髄液所見の検討
上床尚, 足澤萌奈美, 野村太一, 藤井信太朗, 田中大貴, 工藤彰彦, 白井慎一, 岩田育子, 松島理明, 矢口裕章, 南場研一, 石田晋, 矢部一郎, 日本神経学会学術大会プログラム・抄録集, 66th, 2025年

外直筋異常を合併したmonocular elevation deficiencyに対してKnapp法手術を施行した1例—Surgical management for a case of monocular elevation deficiency complicated by lateral rectus muscle anomaly using the Knapp procedure—第80回 日本弱視斜視学会総会 ; 学術展示「非共同性斜視」
角田 佑香, 安藤 亮, 石田 晋, 眼科臨床紀要, 18, 3, 153, 157, 2025年
東京 : 眼科臨床紀要会, 日本語

杆体1色覚の一家系
平岡美紀, 平岡美紀, 平岡美紀, 柴田有花, 向中野実央, 藤田穂波, 安藤亮, 鳥居薫子, 堀田喜裕, 石田晋, 山田崇弘, 日本遺伝カウンセリング学会誌, 46, 2, 2025年

眼瞼悪性腫瘍を自己摘出した認知症患者の一例
渡邉竜也, 加瀬論, 水門由佳, 松野吉宏, 石田晋, 眼科臨床紀要, 18, 1, 2025年

臨床的に脂腺癌が疑われた眼瞼apocrine mixed tumorの1例
水門由佳, 加瀬諭, 高桑恵美, 石田晋, 眼科臨床紀要, 18, 1, 2025年

糖尿病網膜症の重症度別の脈絡膜血管構造解析
加瀬諭, 遠藤弘毅, 高橋光生, 伊藤有希, 園田祥三, 迫口智紀, 寺崎寛人, 勝田聡, 石田晋, 加瀬学, 日本糖尿病眼学会総会講演抄録集, 31st, 2025年

糖尿病網膜症を伴う多発性後極部網膜色素上皮症に巨大な網膜下増殖を生じた一例
太田篤志, 福津佳苗, 齋藤理幸, 有田拓矢, 清野修平, 三田村瑞穂, 清野有紀子, 董震宇, 安藤亮, 加瀬諭, 石田晋, 日本糖尿病眼学会総会講演抄録集, 31st, 2025年

北大眼科における血管新生緑内障に対するチューブシャントの術後成績の検討
菊地香澄, 董震宇, 韓昇煕, 田川義晃, 木嶋理紀, 石田晋, 日本糖尿病眼学会総会講演抄録集, 31st, 2025年

我が国のVEGF阻害薬 種類と特徴
石田晋, 日本の眼科, 96, 2, 2025年

外直筋異常を合併したmonocular elevation deficiencyに対してKnapp法手術を施行した1例
角田佑香, 安藤亮, 石田晋, 眼科臨床紀要, 18, 3, 2025年

難治性緑内障に対するAhmed緑内障バルブを用いたチューブシャント手術成績
韓昇熙, 木嶋理紀, 菊地香澄, 田川義晃, DONG Zhenyu, 新海晃弘, 石田晋, あたらしい眼科, 42, 7, 2025年

眼瞼縁に発生したlobular capillary hemangiomaの1例
水門由佳, 石田晋, 加瀬諭, 加瀬諭, 種井善一, 九州眼科学会プログラム・講演抄録集, 95th, 2025年

Involvement of epidermal growth factor receptor pathway in experimental autoimmune uveoretinitis
Koichi Yokoi, Kenichi Namba, Miyuki Murata, Kayo Suzuki, Keitaro Hase, Daiju Iwata, Nobuyoshi Kitaichi, Miki Hiraoka, Susumu Ishida, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 65, 7, 2024年06月
英語, 研究発表ペーパー・要旨（国際会議）

著者インタビュー Guest 高橋綾子先生—日本人のヒット論文 : 本音で語る苦労話(第24回) ; OCT Angiographyで検出されたフォン・ヒッペル・リンドウ病における新たな網膜血管腫の臨床的特徴 : Ophthalmology掲載論文
高橋 綾子, 石田 晋, 園田 康平, Retina medicine : journal of retina medicine : 網膜・硝子体領域を中心とした医学情報誌 / Retina Medicine誌編集委員会 編, 13, 2, 151, 154, 2024年
東京 : 先端医学社, 日本語

老化と眼疾患—Aging and ocular diseases—特集 老化と疾患
安藤 亮, 石田 晋, 日本臨床 = Japanese journal of clinical medicine, 82, 1, 59, 65, 2024年01月
東京 : 日本臨床社, 日本語

間欠性外斜視における外直筋異常の有無による手術効果の比較
廣岡季里子, 安藤亮, 石橋裕香, 金泉沙宝, 木野田さくら, 清野有紀子, 石田晋, 眼科臨床紀要, 17, 3, 2024年

光干渉断層計で中心窩に高反射病変を認めたムコリピドーシスIII型の1例
庄子尚子, 安藤亮, 埜瀬菜々子, 清野有紀子, 門郁, 門郁, 廣岡季里子, 石田晋, 眼科臨床紀要, 17, 6, 2024年

緑内障眼に対する全層角膜移植術,角膜内皮移植術の術後経過の検討
櫻井淳, 石田晋, 木嶋理紀, 田川義晃, 大口剛司, 董震宇, 長谷敬太郎, 菊地香澄, 西村萌美, 金谷莉奈, 日本角膜学会総会・日本角膜移植学会プログラム・抄録集, 48th-40th, 2024年

糖尿病が網膜血管面積と動脈硬化指標の関係に与える影響
福津佳苗, 齋藤理幸, 野田航介, 野田航介, 石田晋, 日本糖尿病眼学会総会講演抄録集, 30th, 2024年

網膜症未発症糖尿病眼の脈絡膜血管構造
加瀬諭, 遠藤弘毅, 高橋光生, 伊藤有希, 園田祥三, 迫口智紀, 寺崎寛人, 勝田聡, 石田晋, 加瀬学, 日本糖尿病眼学会総会講演抄録集, 30th, 2024年

抗VEGF時代のアンメットニーズ:糖尿病黄斑虚血(DMI)の病態理解と治療戦略
石田晋, 日本糖尿病眼学会総会講演抄録集, 30th, 2024年

治療抵抗性糖尿病黄斑浮腫に対する嚢胞切開併施硝子体手術後のAIによる嚢胞面積解析
三田村瑞穂, 齋藤理幸, 廣岡季里子, 董震宇, 安藤亮, 加瀬諭, 石田晋, 日本糖尿病眼学会総会講演抄録集, 30th, 2024年

持続的な出血を来した結膜悪性黒色腫の1例
加瀬諭, 水門由佳, 三田村瑞穂, 岡田宏美, 石田晋, 日本眼科学会雑誌, 128, 2024年

ぶどう膜炎における硝子体内酸化リン脂質の変化と抗酸化剤によるEAU病態の軽症化
平岡美紀, 平岡美紀, DEDY Ariwansa, DURGA Paudel, 安彦善裕, 北市伸義, 北市伸義, 南場研一, 石田晋, 日本眼科学会雑誌, 128, 2024年

抗α-enolase抗体陽性自己免疫性網膜症における抗体価の検討
安藤亮, 堀尾瑠奈, 吉田志帆, 田中孝幸, 秦雅貴, 三田村瑞穂, 福津佳苗, 清野有紀子, 董震宇, 齋藤理幸, 加瀬諭, 村田美幸, 石田晋, 日本眼科学会雑誌, 128, 2024年

実験的自己免疫性ぶどう膜網膜炎における上皮成長因子受容体経路の検討
横井康一, 南場研一, 村田美幸, 岩田大樹, 岩田大樹, 長谷敬太郎, 北市伸義, 平岡美紀, 北市伸義, 平岡美紀, 鈴木佳代, 石田晋, 日本眼科学会雑誌, 128, 2024年

nAMDおよびDMEにおけるファリシマブの実臨床VOYAGER研究:ベースラインおよび3か月データ
石田晋, 安川力, 吉田茂生, 辻村淳, 鈴木智之, BENGUS Monica, CHI Gloria C., GILBERG Frank, SCHEIDL Stefan, SHETH Veeral, GUYMER Robyn, 日本眼科学会雑誌, 128, 2024年

糖尿病網膜症診療における血管内皮増殖因子(VEGF)阻害薬の種類と特色
石田晋, 糖尿病学の進歩, 58th, 2024年

AIを用いた糖尿病黄斑浮腫のmacular fluidの性状が視力に与える影響の検討
三田村瑞穂, 齋藤理幸, 廣岡季里子, 董震宇, 安藤亮, 加瀬諭, 石田晋, 日本眼科学会雑誌, 128, 2024年

網膜色素上皮腺腫が疑われた網膜下腫瘍
加瀬諭, 石田晋, 清水亜衣, 九州眼科学会プログラム・講演抄録集, 94th, 2024年

Neodymium(Nd):YAGレーザー照射3か月後に眼内炎様の所見を呈し眼球摘出術に至ったぶどう膜悪性黒色腫の1例
西村萌美, 加瀬諭, 水門由佳, 外丸詩野, 石田晋, 日本眼科学会雑誌, 128, 10, 783, 788, 2024年
東京 : 日本眼科学会, 日本語

deep learningを用いた網膜動静脈面積の加齢性変化の性別解析
三田村瑞穂, 齋藤理幸, 福津佳苗, 董震宇, 安藤亮, 加瀬諭, 村田美幸, 野田航介, 野田航介, 石田晋, 日本抗加齢医学会総会プログラム・抄録集, 24th, 2024年

Attention付加による眼底画像からの血圧脈波速度の予測
三田村瑞穂, 齋藤理幸, 福津佳苗, 董震宇, 安藤亮, 加瀬諭, 村田美幸, 野田航介, 石田晋, 日本眼循環学会講演抄録集, 40th, 2024年

パキコロイドの病態~ズバリ私はこう考える~〈5〉 Two-hit theoryは脈絡膜の循環動態および曲率変化から支持される
石田晋, 日本眼循環学会講演抄録集, 40th, 2024年

免疫チェックポイント阻害剤による原田病様ぶどう膜炎の脈絡膜循環
加瀬諭, 山下結衣, 石田晋, 日本眼循環学会講演抄録集, 40th, 2024年

甲状腺眼症に伴う圧迫性視神経症をより早期に診断できなかったかのご相談
新海晃弘, 新明康弘, 新明康弘, 田川義晃, 韓昇煕, 荻野陽, 中村佳代子, 陳進輝, 石田晋, 神経眼科, 41, 2024年

汎ぶどう膜炎に伴う網膜血管増殖性腫瘍が10年後に別部位に再発した1例
茶木駿, 南場研一, 岩田大樹, 水内一臣, 長谷敬太郎, 鈴木佳代, 荻野陽, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 60th-57th-7th, 2024年

白血病脈絡膜症のマルチモダルイメージング
廣岡季里子, 南場研一, 荻野陽, 鈴木佳代, 長谷敬太郎, 橋本大吾, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 60th-57th-7th, 2024年

ぶどう膜炎に伴う治療抵抗性嚢胞状黄斑浮腫に対してアダリムマブが著効した1例
平岡美紀, 平岡美紀, 南場研一, 荻野陽, 岩田大樹, 岩田大樹, 鈴木佳代, 水内一臣, 水内一臣, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 60th-57th-7th, 2024年

急速に増大した脱分化型眼窩原発脂肪肉腫の1例
加瀬諭, 前田拓, 大塚紀幸, 水門由佳, 石田晋, 日本眼窩疾患シンポジウムプログラム・抄録集, 38th, 2024年

脈絡膜画像パターン認識から作成したpachychoroid indexによるnAMD評価の妥当性
有田拓矢, 安藤亮, 齋藤理幸, 保坂広野, 三田村瑞穂, 福津佳苗, 廣岡季里子, 董震宇, 加瀬諭, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 63rd (CD-ROM), 2024年

中心性漿液性脈絡網膜症の脈絡膜体積減少に伴う脈絡膜曲率の変化
山下結衣, 齋藤理幸, 廣岡季里子, 三田村瑞穂, 董震宇, 安藤亮, 加瀬諭, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 63rd (CD-ROM), 2024年

糖尿病黄斑虚血の臨床的意義と分子標的治療の可能性 : 網膜血管再構築のための新たな介入戦略—Diabetic Macular Ischemia : Its Clinical Significance and Possibility of Molecular Targeting Therapy : Novel Treatment Strategy Aimed at Retinal Revascularization
石田 晋, 日本眼科學會雜誌 = Journal of Japanese Ophthalmological Society, 127, 8, 725, 740, 2023年08月
東京 : 日本眼科学会, 日本語

マルチモーダルイメージングによる眼科疾患の診断と病態解明 6.強膜脈絡膜石灰化症のマルチモーダルイメージング
三田村 瑞穂, 加瀬 諭, 石田 晋, 眼科, 65, 6, 565, 570, 2023年06月05日
金原出版

3大ぶどう膜炎の長期経過の検討—Evaluation of Long-term Outcomes of Three Major Etiologies of Panuveitis—学会原著 第126回日眼総会
北市 伸義, 平岡 美紀, 伊東 崇子, 南場 研一, 岩田 大樹, 水内 一臣, 董 震宇, 堀江 幸弘, 福原 淳一, 加瀬 諭, 大野 重昭, 石田 晋, 日本眼科學會雜誌 = Journal of Japanese Ophthalmological Society, 127, 4, 456, 462, 2023年04月
東京 : 日本眼科学会, 日本語

専門分野の選び方,深め方
石田 晋, 小沢 洋子, 近藤 峰生, 園田 康平, 中澤 徹, 安川 力, 山城 健児, Retina Medicine, 12, 1, 1, 8, 2023年04月
(株)先端医学社, 日本語

専門分野の選び方,深め方
石田 晋, 小沢 洋子, 近藤 峰生, 園田 康平, 中澤 徹, 安川 力, 山城 健児, Retina Medicine, 12, 1, 1, 8, 2023年04月
(株)先端医学社, 日本語

マルチモーダルイメージングによる眼科疾患の診断と病態解明 3.脈絡膜大血管(choroidal macrovessel)の眼循環:パキコロイド関連疾患との異同
片岡 慶次, 加瀬 諭, 石田 晋, 眼科, 65, 3, 265, 270, 2023年03月05日
金原出版

マルチモーダルイメージングによる眼科疾患の診断と病態解明 1.自己免疫性網膜症とanti-enolase drusen
安藤 亮, 石田 晋, 眼科, 65, 1, 69, 78, 2023年01月05日
金原出版

歯痛と眼痛が関連痛を呈した1例
金谷莉奈, 田川義晃, 片岡慶次, 渡邉竜也, 西村萌美, 菊地香澄, 野田友子, 木嶋理紀, 岩田大樹, 大口剛司, 石田晋, 日本眼科学会雑誌, 127, 2023年

真菌性副鼻腔炎を合併した重症筋無力症の一例
野見山慶, 田川義晃, 新明康弘, 新明康弘, 岩田育子, 中薗彬, 岡田宏美, 藤田幸大, 金谷莉奈, 荻野陽, 新海晃弘, 中村佳代子, 石田晋, 神経眼科, 40, 2023年

本態性眼瞼痙攣患者における臨床的特徴の検討
金谷莉奈, 田川義晃, 新明康弘, 新明康弘, 藤田幸大, 荻野陽, 新海晃弘, 菊地香澄, 長谷敬太郎, 中村佳代子, 石田晋, 神経眼科, 40, 2023年

眼瞼痙攣患者の光遮断下,点眼麻酔投与下における最大開瞼時間の検討
藤田幸大, 田川義晃, 新明康弘, 新明康弘, 金谷莉奈, 荻野陽, 新海晃弘, 菊地香澄, 長谷敬太郎, 中村佳代子, 石田晋, 神経眼科, 40, 2023年

副鼻腔炎に眼瞼痙攣を合併した1例
成田真央, 田川義晃, 新明康弘, 中薗彬, 藤田幸大, 荻野陽, 新海晃弘, 中村佳代子, 石田晋, 神経眼科, 40, 2023年

原田病患者にみられた反時計回りに移動する片眼1/4盲
新海晃弘, 新明康弘, 新明康弘, 藤田幸大, 荻野陽, 田川義晃, 中村佳代子, 陳進輝, 石田晋, 神経眼科, 40, 2023年

北海道大学病院眼科におけるDSAEK後の眼圧上昇の検討
藤田幸大, 田川義晃, 木嶋理紀, 渡邉竜也, 金谷莉奈, 西村萌美, 菊地香澄, 長谷敬太郎, DONG Zhenyu, 大口剛司, 石田晋, 日本緑内障学会抄録集, 34th, 2023年

私の治療 糖尿病網膜症
齋藤理幸, 石田晋, 週刊日本医事新報, 5189, 2023年

網膜色素上皮細胞におけるleucine-rich repeat kinase 2過剰発現の影響
水門由佳, 村田美幸, 野田航介, 石田晋, 日本眼科学会雑誌, 127, 2023年

網膜血管分布情報を用いた深層学習による糖尿病の検出精度
福津佳苗, 齋藤理幸, 野田航介, 田中孝幸, 村田美幸, 加瀬諭, 道家充, 石田晋, 日本眼科学会雑誌, 127, 2023年

急性後天共同性内斜視の手術成績と定量方法の検討
菅野杏, 安藤亮, 廣岡季里子, 石橋裕香, 山下結衣, 庄子尚子, 福津佳苗, 清野有紀子, 門郁, 中村佳代子, 中村佳代子, 石田晋, 眼科臨床紀要, 16, 4, 2023年

治療前後で角膜神経の観察ができたビタミンA欠乏症の1例
竹田迪葉, 田川義晃, 廣岡季里子, 安藤亮, 片岡慶次, 渡邉竜也, 西村萌美, 金谷莉奈, 菊地香澄, 野田友子, 木嶋理紀, 岩田大樹, 大口剛司, 石田晋, 日本眼科学会雑誌, 127, 2023年

多発するドルーゼン様沈着物と杆体系優位の網膜電図異常を呈したAlport症候群の1例
田中孝幸, 安藤亮, 齋藤理幸, 加瀬諭, 野田航介, 石田晋, 日本眼科学会雑誌, 127, 2023年

非典型的な経過を辿った急性後部多発性斑状色素上皮症の1例
高橋真生, 安藤亮, 石田晋, 眼科臨床紀要, 16, 11, 2023年

著者インタビュー Guest 山口宗男先生—日本人のヒット論文 : 本音で語る苦労話(第22回) ; 糖尿病網膜症における硝子体界面マクロファージとHyperreflective foci : Diabetes掲載論文
山口 宗男, 石田 晋, 小沢 洋子, Retina medicine : journal of retina medicine : 網膜・硝子体領域を中心とした医学情報誌 / Retina Medicine誌編集委員会 編, 12, 2, 175, 178, 2023年
東京 : 先端医学社, 日本語

非典型的な経過を辿った急性後部多発性斑状色素上皮症の1例—A case of acute posterior multifocal placoid pigment epitheliopathy with an atypical course—第61回 日本網膜硝子体学会総会 ; 一般演題(学術展示)「その他」
髙橋 真生, 安藤 亮, 石田 晋, 眼科臨床紀要, 16, 11, 784, 789, 2023年
東京 : 眼科臨床紀要会, 日本語

中心性漿液性脈絡網膜症へのreduced fluence光線力学療法の成績と脈絡膜循環の検討
横井康一, 安藤亮, 山下結衣, 廣岡季里子, 三田村瑞穂, 福津佳苗, 田中孝幸, 董震宇, 齋藤理幸, 加瀬諭, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 62nd, 2023年

肋間帯状疱疹後のHorner 症候群に対しブリモニジン酒石酸塩点眼が有効であった1例
庄子尚子, 田川義晃, 新明康弘, 新海晃弘, Dong Yoko, 中村佳代子, 陳進輝, 石田晋, 神経眼科, 40, 4, 2023年

乳癌による網膜転移の1例
三田村瑞穂, 加瀬諭, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 62nd, 2023年

トリグリセリド異常高値を伴った糖尿病網膜症の1例
福津佳苗, 齋藤理幸, 南場研一, 千葉麻夕子, 堤雅幸, 高橋由華, 泉原里美, 藤井渉, 藤井渉, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 62nd, 2023年

萎縮型加齢黄斑変性のdiffuse trickling patternにおける網膜電図所見
田中孝幸, 安藤亮, 廣岡季里子, 齋藤理幸, 董震宇, 加瀬諭, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 62nd, 2023年

COVID-19感染後に急性帯状潜在性網膜外層症を生じた1症例
秦雅貴, 董震宇, 田中孝幸, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 62nd, 2023年

Leucine-rich repeat kinase2のキナーゼ活性亢進がマウスの網膜機能に及ぼす影響
村田美幸, 水門由佳, 野田航介, 野田航介, 西村萌美, 横井康一, 吉田志帆, 石田晋, 日本眼薬理学会プログラム・講演抄録集, 43rd, 2023年

眼底画像と網膜血管位置情報を用いた深層学習による糖尿病の有無の予測
福津佳苗, 齋藤理幸, 野田航介, 村田美幸, 田中孝幸, 加瀬諭, 道家充, 加瀬学, 石田晋, 日本糖尿病眼学会総会講演抄録集, 29th, 2023年

治療抵抗性糖尿病黄斑浮腫の硝子体手術における嚢胞切開併施の有無での嚢胞面積の変化
三田村瑞穂, 齋藤理幸, 廣岡季里子, 董震宇, 安藤亮, 加瀬諭, 野田航介, 石田晋, 日本糖尿病眼学会総会講演抄録集, 29th, 2023年

ぶどう膜炎の経過中に脈絡膜新生血管(CNV)を併発した症例の臨床像
荻野陽, 南場研一, 岩田大樹, 鈴木佳代, 水内一臣, 水内一臣, 平岡美紀, 平岡美紀, 北市伸義, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 59th-56th-65th-11th, 2023年

トファシチニブが奏効した脊椎関節炎に伴う汎ぶどう膜炎の一例
若林彩乃, 南場研一, 岩田大樹, 鈴木佳代, 北市伸義, 竹山脩平, 渥美達也, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 59th-56th-65th-11th, 2023年

機械学習による3大ぶどう膜炎の視力予後予測因子の検討
吉川一平, 吉川一平, 出井涼介, 平岡美紀, 平岡美紀, 南場研一, 岩田大樹, 石田晋, 中嶋和夫, 中嶋和夫, 北市伸義, 北市伸義, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 59th-56th-65th-11th, 2023年

後部強膜炎における治療前後での脈絡膜循環動態と脈絡膜厚の変化
三田村瑞穂, 加瀬諭, 山下結衣, 廣岡季里子, 石田晋, 日本眼循環学会講演抄録集, 39th, 2023年

急性網膜色素上皮炎とPachychoroid pigment epitheliopathyの臨床的特徴の比較検討
田中孝幸, 董震宇, 廣岡季里子, 三田村瑞穂, 齋藤理幸, 安藤亮, 加瀬諭, 石田晋, 日本眼循環学会講演抄録集, 39th, 2023年

CSC眼における脈絡膜曲率半径の検討
埜瀬菜々子, 齋藤理幸, 廣岡季里子, 董震宇, 安藤亮, 加瀬諭, 石田晋, 日本眼循環学会講演抄録集, 39th, 2023年

萎縮型加齢黄斑変性の診断基準—眼疾患のガイドラインと診療指針 解説とアップデート
安藤 亮, 石田 晋, 眼科, 64, 13, 1377, 1381, 2022年12月
東京 : 金原出版, 日本語

角膜所見から診断に至った多発性骨髄腫の1例—A Case of Multiple Myeloma Diagnosed by Corneal Findings
千葉 麻夕子, 大口 剛司, 三田村 瑞穂, 金谷 莉奈, 野田 友子, 田川 義晃, 木嶋 理紀, 岩田 大樹, 田川 義継, 石田 晋, あたらしい眼科 / メディカル葵出版 [編], 39, 7, 978, 981, 2022年07月
東京 : メディカル葵出版, 日本語

AZOOR Complex—特集 マルチモーダルイメージングでひもとく網膜疾患
齋藤 理幸, 石田 晋, あたらしい眼科 / メディカル葵出版 [編], 39, 6, 739, 746, 2022年06月
東京 : メディカル葵出版, 日本語

抗VEGF薬に関連した感染性/非感染性眼内炎症—Infectious/non-infectious intraocular inflammation concerning the anti-VEGF agents
安藤 亮, 石田 晋, 臨床眼科, 76, 5, 581, 588, 2022年05月
東京 : 医学書院, 日本語

人を惹きつける魅力的なプレゼンをめざそう!
石田 晋, 小沢 洋子, 近藤 峰生, 園田 康平, 中澤 徹, 安川 力, 山城 健児, Retina Medicine, 11, 1, 1, 8, 2022年04月
(株)先端医学社, 日本語

新型コロナウイルスワクチン接種後に汎ぶどう膜炎がみられた1例
荻野陽, 南場研一, 岩田大樹, 鈴木佳代, 平岡美紀, 廣岡季里子, 石田晋, 日本眼科学会雑誌, 126, 2022年

ぶどう膜炎の経過中に視神経病変がみられた眼サルコイドーシスの2例
荻野陽, 南場研一, 岩田大樹, 鈴木佳代, 水内一臣, 平岡美紀, 平岡美紀, 北市伸義, 石田晋, 日本サルコイドーシス/肉芽腫性疾患学会雑誌, 42, 2022年

3大ぶどう膜炎の長期経過の検討
北市伸義, 北市伸義, 平岡美紀, 平岡美紀, 伊東崇子, 伊東崇子, 南場研一, 岩田大樹, 水内一臣, 董震宇, 堀江幸弘, 福原淳一, 加瀬諭, 大野重昭, 大野重昭, 石田晋, 日本眼科学会雑誌, 126, 2022年

Noonan症候群に合併した乳児期発症の小児緑内障の1例
田中友貴, 木嶋理紀, 金谷莉奈, 新海晃弘, 菊地香澄, 山本拓, 新明康弘, 陳進輝, 石田晋, 日本緑内障学会抄録集, 33rd, 2022年

眼瞼痙攣患者の点眼麻酔投与下における最大開瞼時間の検討
田川義晃, 新明康弘, 新海晃弘, 片岡慶次, 木野田さくら, 中村佳代子, 陳進輝, 石田晋, 神経眼科, 39, 2022年

特発性視神経炎の網膜内層厚と残存視野障害の関連性の検討
桂野水那, 新明康弘, 廣岡季里子, 新海晃弘, 田川義晃, 片岡慶次, 木野田さくら, 中村佳代子, 石田晋, 神経眼科, 39, 2022年

当院におけるエタンブトール視神経症の予後についての検討
片岡慶次, 新明康弘, 新明康弘, 新海晃弘, 木野田さくら, 田川義晃, 中村かよこ, 陳進輝, 石田晋, 神経眼科, 39, 2022年

高齢女性にみられた抗MOG抗体陽性視神経炎の1例
木野田さくら, 新明康弘, 新明康弘, 新海晃弘, 片岡慶次, 田川義晃, 中村佳代子, 陳進輝, 石田晋, 神経眼科, 39, 2022年

特発性視神経炎における網膜内層厚と予後の関連
新海晃弘, 新明康弘, 新明康弘, 田川義晃, 片岡慶次, 木野田さくら, 中村佳代子, 陳進輝, 石田晋, 神経眼科, 39, 2022年

涙液中エンケファリンの測定
菊地香澄, 田川義晃, 廣瀬育代, 石田晋, 日本眼薬理学会プログラム・講演抄録集, 42nd, 2022年

増殖糖尿病網膜症における黄斑円孔内に増生した増殖組織の臨床病理学的検討
田中孝幸, 齋藤理幸, 加瀬諭, 高桑恵美, 加藤憲士郎, 石田晋, 糖尿病合併症, 36, Supplement-1, 2022年

Angiopoietin 2とvascular endothelial growth factorの眼炎症への関与
鈴木佳代, 岩田大樹, 南場研一, 長谷敬太郎, 平岡美紀, 村田美幸, 北市伸義, FOXTON Richard, 石田晋, 日本眼科学会雑誌, 126, 2022年

Mueller細胞におけるアクロレインによる単球走化性因子の発現誘導
福津佳苗, 村田美幸, 菊地香澄, 吉田志帆, 野田航介, 石田晋, 日本眼科学会雑誌, 126, 2022年

Spontaneously Diabetic Torii Fattyラットにおける糖尿病眼合併症
菊地香澄, 村田美幸, 野田航介, 加瀬諭, 田川義晃, 影山靖, 篠原雅巳, 笹瀬智彦, 石田晋, 糖尿病合併症, 36, Supplement-1, 2022年

網膜血管分布確率マップを用いた年齢による糖尿病患者の網膜血管変化の検出
福津佳苗, 齋藤理幸, 田中孝幸, 村田美幸, 加瀬諭, 野田航介, 道家充, 石田晋, 糖尿病合併症, 36, Supplement-1, 2022年

レバミピドはコレシストキニン1受容体を介してドライアイの痛覚過敏を抑制する
田川義晃, 野田航介, 乙黒兼一, 村田美幸, 石田晋, 日本眼薬理学会プログラム・講演抄録集, 42nd, 2022年

難治性糖尿病黄斑浮腫の嚢胞様腔内フィブリンクロットの臨床病理学的検討
田中孝幸, 齋藤理幸, 加瀬諭, 廣瀬育代, 村田美幸, 高桑恵美, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 61st, 2022年

機械学習によって自動算出された網膜動静脈面積とCardio Ankle Vascular Indexの関係
福津佳苗, 齋藤理幸, 多田篤司, 永井利幸, 村田美幸, 野田航介, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 61st, 2022年

急性後天性共同性内斜視を契機に発見された小脳腫瘍(Lhermitte-Duclos病)の一例
太田純哉, 安藤亮, 清野有紀子, 福津佳苗, 廣岡季里子, 石田晋, 眼科臨床紀要, 15, 4, 2022年

5年間経過を観察し得たposterior polar annular choroidal dystrophyの1例
曽根理紗子, 野田航介, 廣岡季里子, 齋藤理幸, 安藤亮, 加瀬諭, 石田晋, 日本眼科学会雑誌, 126, 2022年

加齢黄斑変性診療の展望 5.加齢黄斑変性の治療 1)光線力学療法の現状と課題
安藤亮, 石田晋, Progress in Medicine, 42, 11, 2022年

治療抵抗性糖尿病黄斑浮腫の硝子体手術における嚢胞切開併施の有無での治療成績の比較
三田村瑞穂, 齋藤理幸, 廣岡季里子, 大田翔一郎, 董震宇, 安藤亮, 加瀬諭, 野田航介, 石田晋, 糖尿病合併症, 36, Supplement-1, 2022年

非典型的な経過を辿った急性後部多発性斑状色素上皮症の1例
高橋真生, 安藤亮, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 61st, 2022年

ブロルシズマブ投与後にpachychoroid GAが誘発されたPEDの一例
谷向哲矢, 董震宇, 田中孝幸, 齋藤理幸, 安藤亮, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 61st, 2022年

Vogt-小柳-原田病に生じた中心性漿液性脈絡網膜症の診断に画像検査が有用であった1例
廣岡季里子, 岩田大樹, 南場研一, 荻野陽, 鈴木佳代, 水内一臣, 平岡美紀, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 58th-55th-64th-10th, 2022年

Plasminogen activator inhibitor-1阻害薬による実験的自己免疫性ぶどう膜炎の軽症化
鈴木佳代, 岩田大樹, 南場研一, 長谷敬太郎, 平岡美紀, 村田美幸, 北市伸義, 大野重昭, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 58th-55th-64th-10th, 2022年

無症候性脈絡膜炎がみられた尿細管間質性腎炎ぶどう膜炎症候群の1例
有田拓矢, 南場研一, 岩田大樹, 鈴木佳代, 荻野陽, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 58th-55th-64th-10th, 2022年

ぶどう膜炎の経過中に視神経病変がみられた眼サルコイドーシスの2例
荻野陽, 南場研一, 岩田大樹, 鈴木佳代, 水内一臣, 水内一臣, 平岡美紀, 平岡美紀, 北市伸義, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 58th-55th-64th-10th, 2022年

硝子体液のセルブロック細胞診が有用であった肺癌の眼内転移の1例
松本光平, 松本光平, 加瀬諭, 南場研一, 岩田大樹, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 58th-55th-64th-10th, 2022年

眼部帯状疱疹後に涙液減少型ドライアイを呈した3例
金谷莉奈, 田川義晃, 野田友子, 木嶋理紀, 岩田大樹, 大口剛司, 田川義継, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 58th-55th-64th-10th, 2022年

Choroidal vascular structures in diabetic patients: a meta-analysis
Satoru Kase, Hiroaki Endo, Mitsuo Takahashi, Masahiko Yokoi, Yuki Ito, Michiyuki Saito, Susumu Ishida, Manabu Kase, Graefe's Archive for Clinical and Experimental Ophthalmology, 259, 12, 3537, 3548, 2021年12月01日
Springer Science and Business Media Deutschland GmbH, 英語, 書評論文,書評,文献紹介等

再発がみられた単純ヘルペスウイルス2型による急性網膜壊死の1例—A case of acute retinal necrosis recurrence caused by herpes simplex virus type 2
清野 修平, 南場 研一, 水内 一臣, 岩田 大樹, 鈴木 佳代, 品川 真有子, 長谷 敬太郎, 石田 晋, 臨床眼科, 75, 12, 1527, 1532, 2021年11月
東京 : 医学書院, 日本語

Histological observation in pachyvessels in a patient with choroidal melanoma
Satoru Kase, Kousuke Noda, Susumu Ishida, International Journal of Ophthalmology, 14, 5, 777, 779, 2021年05月01日
International Journal of Ophthalmology (c/o Editorial Office), 英語, 速報，短報，研究ノート等（学術雑誌）

増殖性変化を伴うアトピー性角結膜炎の治療後にデュピルマブ関連結膜炎がみられた1例
荻野陽, 南場研一, 石田晋, 日本眼科アレルギー学会学術集会プログラム・抄録集, 4th, 2021年

Posterior polar annular choroidal dystrophyが疑われる1例
酒井正人, 董震宇, 谷向哲矢, 七戸夏子, 坂口貴鋭, 高橋光生, 勝田聡, 加瀬学, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 60th, 2021年

原発開放隅角緑内障として紹介された肉芽腫性ぶどう膜炎による続発緑内障の臨床像
秋元亨介, 新明康弘, 新田卓也, 大口剛司, 木嶋理紀, 宇野友絵, 南場研一, 陳進輝, 石田晋, あたらしい眼科, 38, 7, 2021年

Suture trabeculotomyを施行したBlau症候群の1例
秦雅貴, 木嶋理紀, 金谷莉奈, 新海晃弘, 菊池香澄, 山本拓, 大口剛司, 大口剛司, 廣瀬茂樹, 新明康弘, 陳進輝, 石田晋, 日本緑内障学会抄録集, 32nd, 2021年

北海道大学病院における難治性緑内障に対するロングチューブシャントの手術成績
木嶋理紀, 新明康弘, 金谷莉奈, 新海晃弘, 菊地香澄, 山本拓, 大口剛司, 大口剛司, 陳進輝, 石田晋, 日本緑内障学会抄録集, 32nd, 2021年

著明な脈絡膜萎縮に至ったフォークト-小柳-原田病における脈絡膜画像所見
荻野陽, 南場研一, 岩田大樹, 水内一臣, 長谷敬太郎, 鈴木佳代, 石田晋, 日本眼科学会雑誌, 125, 2021年

抗Angopoietin2/Vascular endothelial growth factor二重特異性抗体を用いたぶどう膜炎の軽症化
鈴木佳代, 岩田大樹, 南場研一, 荻野陽, 長谷敬太郎, 水内一臣, 平岡美紀, 北市伸義, FOXTON Richard, 石田晋, 日本眼薬理学会プログラム・講演抄録集, 41st, 2021年

神経障害性疼痛治療薬ミロガバリンが奏効したシェーグレン症候群の一例
相原佑亮, 田川義晃, 大口剛司, 金谷莉奈, 白枝友子, 木嶋理紀, 岩田大樹, 田川義継, 石田晋, 日本角膜学会総会・日本角膜移植学会プログラム・抄録集, 45th-37th, 2021年

角膜所見から診断に至った多発性骨髄腫の一例
千葉麻夕子, 大口剛司, 三田村瑞穂, 三田村瑞穂, 金谷莉奈, 白枝友子, 白枝友子, 田川義晃, 木嶋理紀, 岩田大樹, 田川義継, 石田晋, 日本角膜学会総会・日本角膜移植学会プログラム・抄録集, 45th-37th, 2021年

Purpureocillium lilacinumによる真菌性角膜炎の一例
太田純哉, 田川義晃, 大口剛司, 福本達也, 金谷莉奈, 白枝友子, 木嶋理紀, 岩田大樹, 田川義継, 石田晋, 日本角膜学会総会・日本角膜移植学会プログラム・抄録集, 45th-37th, 2021年

抗アクアポリン4抗体陽性視神経炎における抗核抗体値
新海晃弘, 新明康弘, 田川義晃, 中村佳代子, 陳進輝, 石田晋, 神経眼科, 38, 2021年

脳脊髄液減少症による症候性眼瞼けいれんが疑われた1例
杉村美羽, 田川義晃, 新明康弘, 高橋明弘, 新海晃弘, 中村佳代子, 石田晋, 神経眼科, 38, 2021年

網脈絡膜循環を評価したindolent,nonprogressive,multifocal choroidal lesionsの2例
山下結衣, 齋藤理幸, 廣岡季里子, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 60th, 2021年

眼窩外涙腺摘出ドライアイモデル動物に対する神経障害性疼痛治療薬ミロガバリンの効果
田川義晃, 菊地香澄, 村田美幸, 野田航介, 石田晋, 日本眼薬理学会プログラム・講演抄録集, 41st, 2021年

Spontaneously Diabetic Torii fattyラットの網膜血管の解析
菊地香澄, 野田航介, 村田美幸, 影山靖, 篠原雅巳, 笹瀬智彦, 石田晋, 糖尿病合併症, 35, Supplement-1, 2021年

長期経過観察した抗リカバリン抗体陽性非腫瘍随伴自己免疫性網膜症の1例
田中孝幸, 安藤亮, 神田敦宏, 齋藤航, 齋藤航, 石田晋, 眼科臨床紀要, 14, 7, 2021年

Inferior staphylomaの脈絡膜循環のインドシアニングリーン蛍光眼底造影による検討
横井康一, 齋藤理幸, 廣岡季里子, 山下結衣, 安藤亮, 加瀬諭, 野田航介, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 60th, 2021年

LSFGで網脈絡膜循環の評価が可能であったfocal scleral noduleの2例
埜瀬菜々子, 齋藤理幸, 廣岡季里子, 山下結衣, 安藤亮, 加瀬諭, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 60th, 2021年

多発消失性白点症候群の臨床像と視力予後に寄与する因子
田中孝幸, 齋藤航, 齋藤航, 廣岡季里子, 山下結衣, 齋藤理幸, 安藤亮, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 60th, 2021年

著者インタビュー Guest 鈴村文那先生—日本人のヒット論文 : 本音で語る苦労話(第17回) ; 糖尿病網膜症におけるω3脂肪酸とその代謝産物18-HEPEによるBDNFを介した網膜神経保護効果の検討 : Diabetes掲載論文
鈴村 文那, 石田 晋, 小沢 洋子, Retina medicine : journal of retina medicine : 網膜・硝子体領域を中心とした医学情報誌 / Retina Medicine誌編集委員会 編, 10, 1, 56, 58, 2021年
東京 : 先端医学社, 日本語

北海道大学病院における眼内リンパ腫のMyd88の発現,遺伝子変異
加瀬諭, 南場研一, 岩田大樹, 小野澤真弘, 岡田宏美, 水内一臣, 伊東崇子, 伊東崇子, 北市伸義, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 57th-54th-63rd-9th, 2021年

眼内リンパ腫における血清と硝子体液中の可溶性インターロイキン2受容体の検討
鈴木佳代, 南場研一, 加瀬諭, 荻野陽, 岩田大樹, 水内一臣, 平岡美紀, 平岡美紀, 北市伸義, 北市伸義, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 57th-54th-63rd-9th, 2021年

眼底自発蛍光が再発検出・治療選択に有用であった急性後部多発性斑状色素上皮症の1例
横井康一, 南場研一, 岩田大樹, 水内一臣, 長谷敬太郎, 鈴木佳代, 廣岡季里子, 関根伸子, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 57th-54th-63rd-9th, 2021年

脈絡膜炎の併発が考えられた特発性視神経網膜炎の1例
廣岡季里子, 南場研一, 有塚舞, 清野修平, 清野修平, 田川義晃, 山下結衣, 岩田大樹, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 57th-54th-63rd-9th, 2021年

Laser speckle flowgraphy findings in focal scleral nodule
Yui Yamashita, Michiyuki Saito, Kiriko Hirooka, Susumu Ishida, Graefe's Archive for Clinical and Experimental Ophthalmology, 2021年
Springer Science and Business Media Deutschland GmbH, 英語, 速報，短報，研究ノート等（学術雑誌）

Attenuation of experimental autoimmune uveoretinitis in mice by IKKβ inhibitor IMD-0354.
Ye Liu, Nobuyoshi Kitaichi, Di Wu, Keitaro Hase, Masashi Satoh, Daiju Iwata, Kenichi Namba, Atsuhiro Kanda, Kousuke Noda, Akiko Itai, Kazuya Iwabuchi, Susumu Ishida, Biochemical and biophysical research communications, 525, 3, 589, 594, 2020年02月27日, ［国際誌］
Uveitis is a sight-threatening intraocular inflammatory disease that accounts for almost 10% of blindness worldwide. NF-κB signaling plays pivotal roles in inflammatory diseases. We have reported that IMD-0354, which inhibits NF-κB signaling via selective blockade of IKK-β, suppresses inflammation in several ocular disease models. Here, we examined the therapeutic effect of IMD-0354 in an experimental autoimmune uveoretinitis (EAU) model, a well-established animal model for endogenous uveitis in humans. Systemic administration of IMD-0354 significantly suppressed the clinical and histological severity, inflammatory edema, and the translocation of NF-κB p65 into the nucleus of retinas in EAU mice. Furthermore, IMD-0354 treatment significantly inhibited the levels of several Th1/Th17-mediated pro-inflammatory cytokines in vitro. Our current data demonstrate that inhibition of IKKβ with IMD-0354 ameliorates inflammatory responses in the mouse EAU model, suggesting that IMD-0354 may be a promising therapeutic agent for human endogenous uveitis., 英語

多発消失性白点症候群と点状脈絡膜内層症の病変混在例の臨床像
廣岡季里子, 齋藤航, 齋藤航, 山下結衣, 橋本勇希, 橋本勇希, 南場研一, 野田航介, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 59th, 2020年

線維柱帯切除術後早期の限局性濾過胞からの房水漏出に対し,結膜縫合に濾過胞再建術を併用することで房水漏出が消失した3例
相原佑亮, 陳進輝, 木嶋理紀, 大口剛司, 新明康弘, 石田晋, あたらしい眼科, 37, 4, 2020年

当院におけるマイクロフックトラベクロトミーの術後短期成績
新海晃弘, 木嶋理紀, 金谷莉奈, 菊地香澄, 山本拓, 大口剛司, 新明康弘, 陳進輝, 廣瀬茂樹, 石田晋, 日本緑内障学会抄録集, 31st, 2020年

眼内悪性リンパ腫に続発した高眼圧眼に対し経強膜的毛様体光凝固術を行なった一例
金谷莉奈, 木嶋理紀, 新海晃弘, 菊地香澄, 山本拓, 岩田大樹, 大口剛司, 新明康弘, 陳進輝, 石田晋, 日本緑内障学会抄録集, 31st, 2020年

多彩な表現型を呈し常染色体優性遺伝を示した小児緑内障の一家系
柴田有紀子, 陳進輝, 布施昇男, 新明康弘, 木嶋理紀, 大口剛司, 石田晋, 日本眼科学会雑誌, 124, 2020年

家族性アミロイドポリニューロパチーによる神経麻痺性角膜症の一例
金谷莉奈, 大口剛司, 松本光平, 田川義晃, 白枝友子, 木嶋理紀, 岩田大樹, 田川義継, 石田晋, 日本角膜学会総会・日本角膜移植学会プログラム・抄録集, 44th-36th, 2020年

ビタミンA欠乏症による角結膜上皮の角化にビタミンA配合点眼が有効であった1例
白枝友子, 白枝友子, 田川義晃, 大口剛司, 金谷莉奈, 木嶋理紀, 岩田大樹, 田川義継, 石田晋, 日本角膜学会総会・日本角膜移植学会プログラム・抄録集, 44th-36th, 2020年

肋間帯状疱疹後のHorner症候群に対しブリモニジン酒石酸塩点眼が有効であった1例
庄子尚子, 田川義晃, 新明康弘, 新海晃弘, 董陽子, 中村佳代子, 陳進輝, 石田晋, 神経眼科, 37, 2020年

交通外傷後に左同名半盲と両眼の視力低下,瞳孔異常を認めた1例
片岡慶次, 新明康弘, 渡邉竜也, 相原佑亮, 田邉章浩, 新海晃弘, 田川義晃, 陳進輝, 石田晋, 神経眼科, 37, 2020年

MELAS患者における網膜内層菲薄化のOCTによる観察
新海晃弘, 新明康弘, 廣岡季里子, 田川義晃, 中村佳代子, 陳進輝, 石田晋, 神経眼科, 37, 2020年

Cochet-bonnet角膜知覚計を用いた角膜の空間的2点識別覚に対する検討
田川義晃, 大口剛司, 長谷川綾華, 金谷莉奈, 白枝友子, 木嶋理紀, 岩田大樹, 田川義継, 石田晋, 日本眼科学会雑誌, 124, 2020年

網膜症未発症の糖尿病眼における脈絡膜厚:系統的レビューとメタ解析
遠藤弘毅, 加瀬諭, 齋藤理幸, 横井匡彦, 高橋光生, 石田晋, 加瀬学, 糖尿病合併症, 34, Supplement 1, 2020年

黄斑部毛細血管拡張症type 2患者における黄斑部脈絡膜血流評価
新海晃弘, 齋藤航, 齋藤航, 廣岡季里子, 橋本勇希, 橋本勇希, 齋藤理幸, 野田航介, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 59th, 2020年

OCT angiography法を用いて観察した網膜血管増殖性腫瘍の1例
谷向哲矢, 野田航介, 村田美幸, 廣岡季里子, 加瀬諭, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 59th, 2020年

網膜色素上皮細胞における血管新生因子ガレクチン-1発現制御機構の解明
山本拓, 神田敦宏, 加瀬諭, 村田美幸, 石田晋, 日本眼科学会雑誌, 124, 2020年

小児眼における光干渉断層計を用いた固視検査の有用性
廣岡季里子, 安藤亮, 橋本勇希, 長谷川裕香, 柴田有紀子, 鈴木佳代, 溝口亜矢子, 石田晋, 眼科臨床紀要, 13, 6, 2020年

裂孔原性網膜剥離を生じたCoats病の1例
品川真有子, 加瀬諭, 田中孝幸, 酒井正人, 清野有紀子, 齋藤理幸, 安藤亮, 野田航介, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 59th, 2020年

網膜血管分布密度マップを用いた網膜血管面積の加齢による変化
田中孝幸, 齋藤理幸, 酒井正人, 清野有紀子, 品川真有子, 安藤亮, 加瀬諭, 野田航介, 道家充, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 59th, 2020年

レボフロキサシン耐性のstaphylococcus capraeによる両眼の細菌性眼内炎をきたした1例
藤田幸大, 齋藤理幸, 木嶋理紀, 田中孝幸, 酒井正人, 清野有紀子, 品川真有子, 安藤亮, 加瀬諭, 野田航介, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 59th, 2020年

網膜血管腫状増殖に対する光線力学的療法トリプル療法の治療成績
酒井正人, 安藤亮, 田中孝幸, 清野有紀子, 品川真有子, 齋藤理幸, 加瀬諭, 野田航介, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 59th, 2020年

中心性漿液性脈絡網膜症への全身循環動態の影響の検討
山下結衣, 齋藤理幸, 廣岡季里子, 橋本勇希, 橋本勇希, 安藤亮, 加瀬諭, 野田航介, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 59th, 2020年

著者インタビュー Guest 藤波芳先生—日本人のヒット論文 : 本音で語る苦労話(第16回) ; Ophthalmology掲載論文 三宅病の臨床的・遺伝的特徴の解明 : 東アジアにおけるコホート研究より
藤波 芳, 石田 晋, 近藤 峰生, Retina medicine : journal of retina medicine : 網膜・硝子体領域を中心とした医学情報誌 / Retina Medicine誌編集委員会 編, 9, 1, 77, 81, 2020年
東京 : 先端医学社, 日本語

Optic nerve head microcirculation in congenital nasal optic disc hypoplasia
Yuka Hasegawa, Yuki Hashimoto, Yasuhiro Shinmei, Susumu Ishida, Graefe's Archive for Clinical and Experimental Ophthalmology, 258, 1, 211, 213, 2020年01月01日
Springer, 英語, 速報，短報，研究ノート等（学術雑誌）

Induced pluripotent stem cells-derived suppressor cells ameliorate experimental autoimmune uveoretinitis in mice
Keitaro Hase, Kenichi Namba, Nobuyoshi Kitaichi, Daiju Iwata, Hyuma Tsuji, Haruka Wada, Ken-ichiro Seino, Susumu Ishida, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 60, 9, 2019年07月
英語, 研究発表ペーパー・要旨（国際会議）

A specific IKKβ inhibitor suppresses experimental autoimmune uveoretinitis in mice
Ye Liu, Nobuyoshi Kitaichi, Di Wu, Keitaro Hase, Daiju Iwata, Kenichi Namba, Atsuhiro Kanda, Kousuke Noda, Susumu Ishida, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 60, 9, 2019年07月
英語, 研究発表ペーパー・要旨（国際会議）

AIと眼科診療
石田 晋, 小沢 洋子, 近藤 峰生, 園田 康平, 高橋 秀徳, 中澤 徹, 三宅 正裕, 安川 力, 山城 健児, Retina Medicine, 8, 1, 1, 9, 2019年04月
(株)先端医学社, 日本語

FGF2遺伝子改変マウスにおけるCNVの抑制とその分子機構
董震宇, 董震宇, サンテフォード アンドレア, アプティ ラジェンドラ, 石田晋, 日本眼科学会雑誌, 123, 2019年

全層角膜移植後の続発緑内障にS-LOT変法を施行した1例
草島萌美, 大口剛司, 木嶋理紀, 新田卓也, 新明康弘, 陳進輝, 石田晋, 眼科手術, 32, 3, 2019年

360°suture trabeculotomy変法において術前眼圧が術後眼圧に及ぼす影響について
木嶋理紀, 新明康弘, 金谷莉奈, 新海晃弘, 菊池香澄, 宇野友絵, 大口剛司, 陳進輝, 石田晋, 日本緑内障学会抄録集, 30th, 2019年

シャルル・ボネ症候群による幻視に痛覚体験を伴う後天性共感覚者の一例
田川義晃, 新明康弘, 赤岡さくら, 長谷川綾華, 新海晃弘, 水門由佳, 石田晋, 神経眼科, 36, 2019年

CTでは診断が困難であった小児眼窩内壁骨折の1例
赤岡さくら, 長谷川綾華, 大澤昌之, 鈴木佳代, 新海晃弘, 水門由佳, 田川義晃, 新明康弘, 石田晋, 神経眼科, 36, 2019年

北海道大学眼科における最近10年間の角膜穿孔の検討
渡邉竜也, 大口剛司, 橋本勇希, 田川義晃, 木嶋理紀, 岩田大樹, 田川義継, 石田晋, 日本角膜学会総会・日本角膜移植学会プログラム・抄録集, 43rd-35th, 2019年

0.4%オキシブプロカイン塩酸塩点眼液による神経麻痺性角膜症を生じた一例
山口瑞穂, 大口剛司, 白枝友子, 田川義晃, 木嶋理紀, 岩田大樹, 田川義継, 石田晋, 日本角膜学会総会・日本角膜移植学会プログラム・抄録集, 43rd-35th, 2019年

慢性眼痛を有する症例の安静時機能的MRIによる検討
田川義晃, 杉森博行, THA KhinKhin, 石田晋, Pain Research, 34, 2, 2019年

下垂体腺腫により眼瞼けいれん様症状を呈した一例
長谷川綾華, 新明康弘, 田川義晃, 赤岡さくら, 新海晃弘, 水門由佳, 石田晋, 神経眼科, 36, 2019年

糖尿病網膜症眼における脈絡膜構造解析
加瀬諭, 遠藤弘毅, 高橋光生, 齋藤理幸, 横井匡彦, 伊藤有希, 勝田聡, 園田祥三, 坂本泰二, 石田晋, 加瀬学, 日本網膜硝子体学会総会プログラム・講演抄録集, 58th, 2019年

Nat Commun & Proc Natl Acad Sci USA掲載雑誌 CCDC102Bと近視性黄斑症の関連 CFH・VIPR2と脈絡膜厚・CSC発症との関連—CCDC102B confers risk of low vision and blindness in high myopia : CFH and VIPR2 as susceptibility loci in choroidal thickness and pachychoroid disease central serous chorioretinopathy—日本人のヒット論文 : 本音で語る苦労話(第14回)
石田 晋, 細田 祥勝, 小沢 洋子, Retina medicine : journal of retina medicine : 網膜・硝子体領域を中心とした医学情報誌 / Retina Medicine誌編集委員会 編, 8, 1, 77, 84, 2019年
東京 : 先端医学社, 日本語

MPO-ANCA陽性ANCA関連血管炎症候群に伴う後部強膜炎の1例
翁欣瑜, 岩田大樹, 南場研一, 鈴木佳代, 水内一臣, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 56th-53rd-62nd-8th, 2019年

視神経乳頭循環動態の経時変化が観察できた原田病に前部虚血性視神経症を合併した1例
廣岡季里子, 南場研一, 山下結衣, 水内一臣, 岩田大樹, 橋本勇希, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 56th-53rd-62nd-8th, 2019年

硝子体網膜リンパ腫におけるセルブロック細胞診の診断率の検討
加瀬諭, 南場研一, 岩田大樹, 水内一臣, 岡田宏美, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 56th-53rd-62nd-8th, 2019年

Epstein-Barrウイルスによる急性網膜壊死の一例
鈴木佳代, 南場研一, 山口瑞穂, 水内一臣, 岩田大樹, 伊東崇子, 北市伸義, 高瀬博, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 56th-53rd-62nd-8th, 2019年

慢性眼痛を有する症例の安静的機能的MRIによる検討
田川義晃, 大口剛司, 杉森博行, KHIN Tha Khin, 木嶋理紀, 岩田大樹, 田川義継, 石田晋, 日本眼科学会雑誌, 123, 2019年

ニューラルネットワークによる眼底写真の網膜動静脈検出
福津佳苗, 齋藤理幸, 野田航介, 村田美幸, 加瀬諭, 柴涼介, 磯貝直己, 道家充, 石田晋, 日本眼循環学会講演抄録集, 36th, 2019年

片眼の視力低下を契機に発見された若年者の内頸動脈-眼動脈瘤の1例　　　　　　　　　　　　　　　
白枝 友子, 新明 康弘, 和田 莉奈, 鈴木 佳代, 中村 佳代子, 杉山 拓, 寳金 清博, 陳 進輝, 石田 晋, 神経眼科, 35, 増補1, 75, 75, 2018年11月
日本神経眼科学会, 日本語

Increased plasma galectin-1 is correlated with advanced glycation end products and interleukin-1β in patients with proliferative diabetic retinopathy
Keitaro Hase, Atsuhiro Kanda, Kousuke Noda, Susumu Ishida, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59, 9, 2018年07月
英語, 研究発表ペーパー・要旨（国際会議）

眼痛を有する患者の安静時機能的MRIによる検討　　　　　　　　　　　　　　　
田川 義晃, 杉森 博行, Tha Khin Khin, 石田 晋, PAIN RESEARCH, 33, 2, 146, 146, 2018年06月
日本疼痛学会, 日本語

生涯アカデミック宣言!　　　　　　　　　　　　　　　
石田 晋, 小沢 洋子, 尾花 明, 栗山 晶治, 近藤 峰生, 園田 康平, 中澤 徹, 安川 力, 山城 健児, Retina Medicine, 7, 1, 1, 8, 2018年04月
(株)先端医学社, 日本語

弱視治療をおこなった広汎な網膜有髄神経線維の4例　　　　　　　　　　　　　　　
福津 佳苗, 安藤 亮, 野崎 真世, 溝口 亜矢子, 石田 晋, 眼科臨床紀要, 11, 4, 300, 300, 2018年04月
眼科臨床紀要会, 日本語

第121回 日本眼科学会総会 評議員会指名講演 眼科のトランスレーショナルリサーチ : 多機能蛋白質に着目した糖尿病網膜症に対する創薬研究—Drug Discovery Research on Diabetic Retinopathy Specifically Focusing on a Moonlighting Protein
野田 航介, 村田 美幸, 稲福 沙織, 松田 剛, 吉田 志帆, 董 陽子, 木下 哲志, 安藤 亮, 藤谷 顕雄, 齋藤 理幸, 董 震宇, 森 祥平, 加瀬 諭, 吉澤 史子, 齋藤 航, 神田 敦宏, 石田 晋, 眞島 行彦, 笹瀬 智彦, 天野 麻穂, 大橋 哲, 西村 伸一郎, 今川 貴仁, 白仁田 明生, 日本眼科學會雜誌 = Journal of Japanese Ophthalmological Society, 122, 3, 223, 247, 2018年03月
東京 : 日本眼科学会, 日本語

眼科のトランスレーショナルリサーチ 多機能蛋白質に着目した糖尿病網膜症に対する創薬研究
野田 航介, 村田 美幸, 稲福 沙織, 松田 剛, 吉田 志帆, 董 陽子, 木下 哲志, 安藤 亮, 藤谷 顕雄, 齋藤 理幸, 董 震宇, 森 祥平, 加瀬 諭, 吉澤 史子, 齋藤 航, 神田 敦宏, 石田 晋, 眞島 行彦, 笹瀬 智彦, 天野 麻穂, 大橋 哲, 西村 伸一郎, 今川 貴仁, 白仁田 明生, 日本眼科学会雑誌, 122, 3, 223, 248, 2018年03月
(公財)日本眼科学会, 日本語

ドライアイ症状を有する患者の安静時機能的MRIによる検討　　　　　　　　　　　　　　　
田川 義晃, 大口 剛司, 杉森 博行, タ・キンキン, 木嶋 理紀, 岩田 大樹, 田川 義継, 石田 晋, 日本眼科学会雑誌, 122, 臨増, 156, 156, 2018年03月
(公財)日本眼科学会, 日本語

眼サルコイドーシスの診断における血液検査・画像検査の有用性　　　　　　　　　　　　　　　
鈴木 佳代, 南場 研一, 水内 一臣, 岩田 大樹, 福原 崇子, 長谷 敬太郎, 濱田 怜, 大野 重昭, 北市 伸義, 石田 晋, 日本眼科学会雑誌, 122, 臨増, 191, 191, 2018年03月
(公財)日本眼科学会, 日本語

多発消失性白点症候群における脈絡膜構造の層別解析　　　　　　　　　　　　　　　
廣岡 季里子, 齋藤 航, 江川 麻理子, 三田村 佳典, 橋本 勇希, 野田 航介, 園田 祥三, 坂本 泰二, 石田 晋, 日本眼科学会雑誌, 122, 臨増, 235, 235, 2018年03月
(公財)日本眼科学会, 日本語

増殖糖尿病網膜症患者における血漿ガレクチン-1と炎症関連分子との相関解析　　　　　　　　　　　　　　　
長谷 敬太郎, 神田 敦宏, 野田 航介, 石田 晋, 日本眼科学会雑誌, 122, 臨増, 237, 237, 2018年03月
(公財)日本眼科学会, 日本語

視神経乳頭黒色細胞腫のOCT angiography所見　　　　　　　　　　　　　　　
菊地 郁, 加瀬 諭, 石田 晋, 日本眼科学会雑誌, 122, 臨増, 279, 279, 2018年03月
(公財)日本眼科学会, 日本語

【免疫疾患と眼炎症】 眼炎症研究の最前線　　　　　　　　　　　　　　　
北市 伸義, 石田 晋, 炎症と免疫, 26, 2, 128, 132, 2018年02月
(株)先端医学社, 日本語

糖尿病網膜症における新規血管新生因子ガレクチン-1の発現調節メカニズム　　　　　　　　　　　　　　　
神田 敦宏, 野田 航介, 齋藤 航, 石田 晋, 日本眼科学会雑誌, 122, 2, 132, 133, 2018年02月
(公財)日本眼科学会, 日本語

中心性漿液性脈絡網膜症を発症した真性多血症の1例
白枝友子, 白枝友子, 野田航介, 廣岡季里子, 橋本勇希, 清水啓史, 鈴木智浩, 藤谷顕雄, 董震宇, 水内一臣, 加瀬諭, 齋藤航, 石田晋, 日本眼循環学会講演抄録集, 35th, 2018年

脈絡膜血管新生における線維芽細胞増殖因2の関与の検討
董震宇, 董震宇, SANTEFORD Andrea, 石田晋, APTE Rajendra, 日本網膜硝子体学会総会プログラム・講演抄録集, 57th, 2018年

線維柱帯切除術後早期の眼局性濾過胞からの房水漏出に対し,ニードリングを併用し房水漏出が消失した3症例
相原佑亮, 陳進輝, 木嶋理紀, 大口剛司, 新明康弘, 石田晋, 日本緑内障学会抄録集, 29th, 2018年

レーザー切糸後に低眼圧黄斑症を来した線維柱帯切除術後の続発開放隅角緑内障の1例
木嶋理紀, 陳進輝, 新明康弘, 宇野友絵, 大口剛司, 新田卓也, 青柳麻衣子, 辻野奈緒子, 勝田佳世, 石田晋, 日本緑内障学会抄録集, 29th, 2018年

眼サルコイドーシスの診断における各種検査の有用性検証
鈴木佳代, 南場研一, 水内一臣, 岩田大樹, 福原崇子, 長谷敬太郎, 濱田怜, 大野重昭, 北市伸義, 石田晋, 日本サルコイドーシス/肉芽腫性疾患学会雑誌, 38, 2018年

ドライアイ症状と全身の慢性疼痛との関連
田川義晃, 大口剛司, 木嶋理紀, 岩田大樹, 田川義継, 石田晋, 日本角膜学会総会・日本角膜移植学会プログラム・抄録集, 42nd-34th, 2018年

眼瞼けいれん患者の安静時機能的MRIによる検討
田川義晃, 新明康弘, 杉森博行, KHIN Tha Khin, 陳進輝, 石田晋, 神経眼科, 35, 2018年

発症前後の脈絡膜形態変化が観察できたacute macular neuroretionpathyの1例
橋本勇希, 齋藤航, 齋藤航, 長谷川裕香, 齋藤理幸, 野田航介, 石田晋, 日本眼循環学会講演抄録集, 35th, 2018年

小児の再発性有痛性眼筋麻痺性ニューロパチーの1例
佐久間愛, 溝口亜矢子, 新明康弘, 安藤亮, 白枝友子, 鈴木佳代, 中村佳代子, 陳進輝, 石田晋, 神経眼科, 35, 2018年

PCVに対するPDTトリプル療法の初回治療と再発治療の比較検討
柴田有紀子, 安藤亮, 安藤亮, 野田航介, 廣岡季里子, 橋本勇希, 鈴木智浩, 清水啓史, 藤谷顕雄, 董震宇, 加瀬諭, 吉澤史子, 吉澤史子, 齋藤航, 齋藤航, 石田晋, 日本網膜硝子体学会総会プログラム・講演抄録集, 57th, 2018年

Ophthalmology掲載論文 Stickler症候群における黄斑低形成—Foveal Hypoplasia in Patients with Stickler Syndrome—日本人のヒット論文 : 本音で語る苦労話(第12回)
石田 晋, 松下 五佳, 近藤 峰生, Retina medicine : journal of retina medicine : 網膜・硝子体領域を中心とした医学情報誌 / Retina Medicine誌編集委員会 編, 7, 1, 75, 81, 2018年
東京 : 先端医学社, 日本語

増殖糖尿病網膜症患者の血漿中における可溶型（プロ）レニン受容体に関連する全身的な要因. Best articles of the year
神田 敦宏, 石田 晋, 北海道医学雑誌, 93, 92, 2018年

眼内血管新生疾患の病態理解と治療の進歩
石田 晋, 医学の歩み.266: 887,, 266, 887, 2018年

原発性眼内悪性リンパ腫の臨床的特徴
加瀬諭, 南場研一, 岩田大樹, 水内一臣, 北市伸義, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 55th-52nd-61st-7th, 2018年

眼サルコイドーシス実態調査〈重症例,遷延例,難治例〉
鈴木佳代, 南場研一, 石原麻美, 水内一臣, 岩田大樹, 福原崇子, 大野重昭, 北市伸義, 石田晋, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 55th-52nd-61st-7th, 2018年

フォークト・小柳・原田病の発症年齢における脈絡膜形態および循環動態の検討　　　　　　　　　　　　　　　
橋本 勇希, 南場 研一, 廣岡 季里子, 水内 一臣, 岩田 大樹, 石田 晋, 日本視能訓練士協会誌, 46, 309, 309, 2017年12月
(公社)日本視能訓練士協会, 日本語

糖尿病網膜症における新規血管新生因子ガレクチン-1の発現調節メカニズム　　　　　　　　　　　　　　　
神田 敦宏, 野田 航介, 齋藤 航, 石田 晋, 生命科学系学会合同年次大会, 2017年度, [1P, 0023], 2017年12月
生命科学系学会合同年次大会運営事務局, 日本語

ステロイド治療と卵巣腫瘍摘出により視機能改善を示した癌関連網膜症の1例
山田 梨佳, 山添 克弥, 久須見 有美, 神田 敦宏, 齋藤 航, 石田 晋, 堀田 一樹, 眼科臨床紀要, 10, 11, 913, 917, 2017年11月
眼科臨床紀要会, 日本語

増殖糖尿病網膜症患者の硝子体中アクロレイン結合蛋白FDP-lysine濃度　　　　　　　　　　　　　　　
森 祥平, 村田 美幸, 野田 航介, 鈴木 智浩, 齋藤 理幸, 安藤 亮, 加瀬 諭, 齋藤 航, 神田 敦宏, 石田 晋, 眼科臨床紀要, 10, 11, 920, 921, 2017年11月
眼科臨床紀要会, 日本語

PDTトリプル療法を行った加齢黄斑変性における治療2年後視力の規定因子　　　　　　　　　　　　　　　
安藤 亮, 野田 航介, 廣岡 季里子, 橋本 勇希, 鈴木 智浩, 森 祥平, 齋藤 理幸, 吉澤 史子, 加瀬 諭, 齋藤 航, 石田 晋, 眼科臨床紀要, 10, 11, 940, 940, 2017年11月
眼科臨床紀要会, 日本語

ステロイドパルス療法が著効した脈絡膜新生血管とAZOORを伴った点状脈絡膜内層症の1例　　　　　　　　　　　　　　　
鈴木 智浩, 加瀬 諭, 森 祥平, 安藤 亮, 齋藤 理幸, 野田 航介, 石田 晋, 眼科臨床紀要, 10, 11, 949, 950, 2017年11月
眼科臨床紀要会, 日本語

朝顔様視神経乳頭眼に発症した急性帯状潜在性網膜外層症の1例　　　　　　　　　　　　　　　
橋本 勇希, 齋藤 航, 齋藤 理幸, 野田 航介, 石田 晋, 眼科臨床紀要, 10, 11, 950, 950, 2017年11月
眼科臨床紀要会, 日本語

【臓器炎症からみた糖尿病および糖尿病性合併症】 慢性炎症と糖尿病網膜症
神田 敦宏, 石田 晋, 糖尿病診療マスター, 15, 10, 851, 855, 2017年10月
(株)医学書院, 日本語

北海道大学眼科における全層角膜移植術の成績　　　　　　　　　　　　　　　
山本 拓, 大口 剛司, 田川 義晃, 木嶋 理紀, 水内 一臣, 岩田 大樹, 田川 義継, 石田 晋, 眼科手術, 30, 4, 707, 709, 2017年10月
(公社)日本眼科手術学会, 日本語

難治性黄斑円孔に対する内境界膜自家移植変法　　　　　　　　　　　　　　　
柴田 有紀子, 齋藤 理幸, 藤谷 顕雄, 鈴木 智浩, 安藤 亮, 森 祥平, 加瀬 諭, 野田 航介, 石田 晋, 眼科臨床紀要, 10, 10, 843, 843, 2017年10月
眼科臨床紀要会, 日本語

Pachychoroid pigment epitheliopathyの臨床像　　　　　　　　　　　　　　　
廣岡 季里子, 齋藤 航, 齋藤 理幸, 森 祥平, 安藤 亮, 橋本 勇希, 加瀬 諭, 野田 航介, 石田 晋, 眼科臨床紀要, 10, 10, 860, 860, 2017年10月
眼科臨床紀要会, 日本語

挙筋整復術を契機に発見された眼球運動制限を伴う眼窩内転移性乳がんの一例　　　　　　　　　　　　　　　
鈴木 佳代, 新明 康弘, 和田 莉奈, 石嶋 漢, 新田 卓也, 陳 進輝, 石田 晋, 神経眼科, 34, 増補1, 58, 58, 2017年10月
日本神経眼科学会, 日本語

日内変動を伴う眼瞼下垂と複視を呈し、重症筋無力症との鑑別を要した脳脊髄液減少症の一例　　　　　　　　　　　　　　　
和田 莉奈, 新明 康弘, 鈴木 佳代, 石嶋 漢, 中村 佳代子, 高橋 明弘, 陳 進輝, 石田 晋, 神経眼科, 34, 増補1, 94, 94, 2017年10月
日本神経眼科学会, 日本語

糖尿病眼における熱ショック蛋白α-クリスタリンと最終糖化産物の発現　　　　　　　　　　　　　　　
加瀬 諭, 石田 晋, 糖尿病合併症, 31, Suppl.1, 341, 341, 2017年10月
(一社)日本糖尿病合併症学会, 日本語

糖尿病網膜症における新規血管新生因子ガレクチン-1の発現調節メカニズム　　　　　　　　　　　　　　　
神田 敦宏, 野田 航介, 齋藤 航, 石田 晋, 糖尿病合併症, 31, Suppl.1, 342, 342, 2017年10月
(一社)日本糖尿病合併症学会, 日本語

網膜グリア細胞に対するアクロレインの作用　　　　　　　　　　　　　　　
野田 航介, 村田 美幸, 吉田 志帆, 神田 敦宏, 石田 晋, 糖尿病合併症, 31, Suppl.1, 347, 347, 2017年10月
(一社)日本糖尿病合併症学会, 日本語

瞼板内角質嚢胞との鑑別を要した眼瞼結膜嚢胞性病変の1例　　　　　　　　　　　　　　　
水門 由佳, 加瀬 諭, 石嶋 漢, 高桑 恵美, 石田 晋, 日本眼腫瘍学会誌, 6, 1, 4, 2017年09月
日本眼腫瘍学会, 日本語

眼皮膚白皮症に角膜内血腫を合併した1例
菊地 郁, 大口 剛司, 田川 義晃, 木嶋 理紀, 水内 一臣, 岩田 大樹, 田川 義継, 石田 晋, 臨床眼科, 71, 8, 1227, 1231, 2017年08月
(株)医学書院, 日本語

視細胞形態に異常を示さなかった急性帯状潜在性網膜外層症の1例　　　　　　　　　　　　　　　
廣岡 季里子, 齋藤 航, 神田 敦宏, 石田 晋, 眼科臨床紀要, 10, 7, 590, 590, 2017年07月
眼科臨床紀要会, 日本語

Rosai-Dorfman病に合併した続発緑内障に対し360.suture trabeculotomy変法が奏効した1例　　　　　　　　　　　　　　　
菊地 香澄, 木嶋 理紀, 新明 康弘, 大口 剛司, 陳 進輝, 南場 研一, 齋藤 航, 石田 晋, 眼科手術, 30, 3, 514, 517, 2017年07月
(公社)日本眼科手術学会, 日本語

A comprehensive analysis of serum levels of prorenin/renin and inflammation-associated molecules in proliferative diabetic retinopathy
Keitaro Hase, Atsuhiro Kanda, Kousuke Noda, Susumu Ishida, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58, 8, 2017年06月
英語, 研究発表ペーパー・要旨（国際会議）

Mechanism in suppression of CCK pathway by rebamipide in trigeminal neurons.
Yoshiaki Tagawa, Kousuke Noda, Ken-ichi Otsuguro, Erdal Tan Ishizuka, Atsuhiro Kanda, Susumu Ishida, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58, 8, 2017年06月
英語, 研究発表ペーパー・要旨（国際会議）

【糖尿病網膜症】 糖尿病網膜症の病態研究と進歩　　　　　　　　　　　　　　　
神田 敦宏, 石田 晋, Diabetes Frontier, 28, 3, 273, 276, 2017年06月
(株)メディカルレビュー社, 日本語

多発消失性白点症候群における年代別の網脈絡膜形態の比較　　　　　　　　　　　　　　　
森 なみ, 橋本 勇希, 長谷川 裕香, 齋藤 航, 石田 晋, 眼科臨床紀要, 10, 6, 513, 513, 2017年06月
眼科臨床紀要会, 日本語

Laser speckle flowgraphyを施行した小児発症のフォークト・小柳・原田病の1例　　　　　　　　　　　　　　　
橋本 勇希, 南場 研一, 廣岡 季里子, 水内 一臣, 岩田 大樹, 齋藤 航, 石田 晋, 眼科臨床紀要, 10, 6, 514, 514, 2017年06月
眼科臨床紀要会, 日本語

非典型的所見を呈した片眼性網膜芽細胞腫の1例　　　　　　　　　　　　　　　
安藤 亮, 加瀬 諭, 野崎 真世, 石田 晋, 眼科臨床紀要, 10, 6, 517, 517, 2017年06月
眼科臨床紀要会, 日本語

(プロ)レニン受容体特異的一本鎖RNA干渉による眼炎症病態の抑制　　　　　　　　　　　　　　　
神田 敦宏, 石塚 タンエルダル, 劉 野, 野田 航介, 石田 晋, 日本抗加齢医学会総会プログラム・抄録集, 17回, 173, 173, 2017年06月
(一社)日本抗加齢医学会, 日本語

【アンチエイジング研究-世界の趨勢と日本】各領域におけるアンチエイジング研究 感覚器のアンチエイジング研究 眼科領域の食品因子研究の現状
北市 伸義, 石田 晋, 医学のあゆみ, 261, 6, 613, 618, 2017年05月
医歯薬出版(株), 日本語

臨床報告Selected 求心性視野狭窄を呈した交通外傷後脳脊髄液減少症
鈴木 佳代, 高橋 明弘, 新明 康弘, 田川 義晃, 野崎 真世, 石嶋 漢, 陳 進輝, 石田 晋, 臨床眼科, 71, 3, 301, 307, 2017年03月
(株)医学書院, 日本語

臨床報告 春季カタルにおけるタクロリムス点眼薬の長期使用成績
品川 真有子, 南場 研一, 北市 伸義, 石田 晋, 臨床眼科, 71, 3, 343, 348, 2017年03月
(株)医学書院, 日本語

【世界のトップを走る日本のドライアイ最前線】 痛みをターゲットとしたドライアイ治療
田川 義晃, 石田 晋, あたらしい眼科, 34, 3, 341, 346, 2017年03月
(株)メディカル葵出版, 日本語

創薬に必要な眼科のドラッグデリバリーシステム(DDS) 後眼部疾患の治療を目的としたドラッグデリバリーシステム「結膜リング」の開発(Drug delivery system(DDS) for innovation of ophthalmic drugs Development of the Conjunctival Ring for Treating Posterior-Segment Eye Diseases)　　　　　　　　　　　　　　　
石田 晋, 日本眼科学会雑誌, 121, 臨増, 34, 34, 2017年03月
(公財)日本眼科学会, 英語

糖尿病網膜症における新規血管新生因子ガレクチン-1の発現調節メカニズム　　　　　　　　　　　　　　　
神田 敦宏, 董 陽子, 野田 航介, 齋藤 航, 石田 晋, 日本眼科学会雑誌, 121, 臨増, 176, 176, 2017年03月
(公財)日本眼科学会, 日本語

眼付属器MALTリンパ腫の診断におけるフローサイトメトリの有用性　　　　　　　　　　　　　　　
加瀬 諭, 石嶋 漢, 浦木 健彦, 鈴木 康夫, 石田 晋, 日本眼科学会雑誌, 121, 臨増, 201, 201, 2017年03月
(公財)日本眼科学会, 日本語

多発消失性白点症候群における脈絡膜層別厚の経時変化　　　　　　　　　　　　　　　
橋本 勇希, 齋藤 航, 長谷川 裕香, 齋藤 理幸, 安藤 亮, 森 祥平, 加瀬 諭, 野田 航介, 石田 晋, 日本眼科学会雑誌, 121, 臨増, 218, 218, 2017年03月
(公財)日本眼科学会, 日本語

三叉神経節細胞におけるレバミピドのコレシストキニン経路抑制機序の検討　　　　　　　　　　　　　　　
田川 義晃, 野田 航介, 宮本 亮, 乙黒 兼一, 石塚 タンエルダル, 神田 敦宏, 石田 晋, 日本眼科学会雑誌, 121, 臨増, 221, 221, 2017年03月
(公財)日本眼科学会, 日本語

RPE特異的なAtp6ap2コンディショナルノックアウトマウスにおける眼の表現型の分析(Analysis of ocular phenotype in RPE-specific Atp6ap2 conditional knockout mice)　　　　　　　　　　　　　　　
石塚 タンエルダル, 神田 敦宏, 野田 航介, 市原 淳弘, 石田 晋, 日本眼科学会雑誌, 121, 臨増, 229, 229, 2017年03月
(公財)日本眼科学会, 英語

両眼の外転神経麻痺を合併した仙骨軟骨肉腫の一例　　　　　　　　　　　　　　　
石嶋 漢, 新明 康弘, 高宮 宗一郎, 関 俊隆, 新田 卓也, 野崎 真世, 中村 佳代, 石田 晋, 日本眼科学会雑誌, 121, 臨増, 317, 317, 2017年03月
(公財)日本眼科学会, 日本語

腫瘍性病変が疑われた結節性後部強膜炎の1例　　　　　　　　　　　　　　　
柴田 有紀子, 加瀬 諭, 南場 研一, 石田 晋, 日本眼科学会雑誌, 121, 臨増, 329, 329, 2017年03月
(公財)日本眼科学会, 日本語