Oct. 2021, Best poster award RIKEN BDR retreat-2021　　　　　　　　　　　　　　　

Oct. 2018, Japan Student Services Organization (JASSO) scholarship award　　　　　　　　　　　　　　　

Oct. 2014, Japan government MEXT scholarship award　　　　　　　　　　　　　　　

Screening of a Fraction with Higher Amyloid β Aggregation Inhibitory Activity from a Library Containing 210 Mushroom Extracts Using a Microliter-Scale High-Throughput Screening System with Quantum Dot Imaging
Gegentuya Huanood, Mahadeva M. M. Swamy, Rina Sasaki, Keiya Shimamori, Masahiro Kuragano, Enkhmaa Enkhbat, Yoshiko Suga, Masaki Anetai, Kenji Monde, Kiyotaka Tokuraku
Foods, 13, 23, 3740, 3740, MDPI AG, 22 Nov. 2024
Scientific journal, Alzheimer’s disease (AD) is a highly prevalent neurodegenerative disease hallmarked by amyloid plaques and neurofibrillary tangles. Amyloid plaques are formed by the amyloid β (Aβ) aggregation, so substances that inhibit this aggregation are useful for preventing and treating AD. Mushrooms are widely used medicinal fungi with high edible and nutritional value. Mushrooms have a variety of biologically active ingredients, and studies have shown that they have certain effects in anti-bacterial, anti-oxidation, anti-inflammatory, anti-tumor, and immune regulation. Previously, we developed a microliter-scale high-throughput screening (MSHTS) system using quantum dot (QD) nanoprobes to screen Aβ aggregation inhibitors. In this study, we appraised the Aβ aggregation inhibitory activity of 210 natural mushrooms from Hokkaido (Japan) and found 11 samples with high activity. We then selected Elfvingia applanata and Fuscoporia obliqua for extraction and purification as these samples were able to suppress Aβ-induced neurocytotoxicity and were readily available in large quantities. We found that the ethyl acetate (EtOAc) extract of E. applanata has high Aβ aggregation inhibitory activity, so we performed silica gel column chromatography fractionation and found that fraction 5 (f5) of the EtOAc extract displayed the highest Aβ aggregation inhibitory activity among all mushroom samples. The half-maximal effective concentration (EC50) value was 2.30 µg/mL, higher than the EC50 of 10.7 µg/mL for rosmarinic acid, a well-known Aβ aggregation inhibitor. This inhibitory activity decreased with further purification, suggesting that some compounds act synergistically. The f5 fraction also inhibited the deposition of Aβ aggregates on the cell surface of human neuroblastoma SH-SY5Y cells. Our expectation is that f5, with additional tests, may eventually prove to be an inhibitor for the prevention of AD.

Biocompatible and Water-Soluble Shortwave-Infrared (SWIR)-Emitting Cyanine-Based Fluorescent Probes for In Vivo Multiplexed Molecular Imaging
Mahadeva M. M. Swamy, Yuta Murai, Kenji Monde, Setsuko Tsuboi, Aravind K. Swamy, Takashi Jin
ACS Applied Materials & Interfaces, 16, 17253, 17266, American Chemical Society (ACS), 01 Apr. 2024, [Peer-reviewed]
English, Scientific journal

Stereochemistry‐activity relationship of ceramide‐induced exosome production to clear amyloid‐β in Alzheimer's disease　　　　　　　　　　　　　　　
Mariam Abdelrasoul, Kohei Yuyama, Mahadeva M. M. Swamy, Yuta Murai, Kenji Monde
Chirality, 35, 9, 577, 585, Apr. 2023, [Peer-reviewed]
Scientific journal

Stereochemistry of Sphingolipids in Ganglioside GM3 Enhances Recovery of Nervous Functionality
Sajeer Koolath, Yuta Murai, Tomoya Suzuki, Mahadeva M, M. Swamy, Seigo Usuki, Kenji Monde
ACS Med. Chem. Lett., in press, 9, 1237, 1241, American Chemical Society (ACS), 2023, [Peer-reviewed]
English, Scientific journal

A near-infrared fluorescent long-chain fatty acid toward optical imaging of cardiac metabolism in living mice　　　　　　　　　　　　　　　
Mahadeva M. M. Swamy, Mohamad Zarif Mohd, Zubir, Mutmainah, Setsuko Tsuboi, Yuta Murai, Kenji Monde, Ken-ichi Hiranoc, Takashi Jin
Analyst, 147, 19, 4206, 4212, Aug. 2022, [Peer-reviewed]
Scientific journal

Shortwave-infrared (SWIR) emitting annexin V for high-contrast fluorescence molecular imaging of tumor apoptosis in living mice　　　　　　　　　　　　　　　
Mahadeva M. M. Swamy, Setsuko Tsuboi, Yuta Murai, Kenji Monde, Takashi Jin
RSC Advances, 12, 30, 19632, 19639, Jun. 2022, [Peer-reviewed]
English, Scientific journal

Shortwave-Infrared fluorescent molecular imaging probes based on π-conjugation extended indocyanine green
Mahadeva M. M. Swamy, Yuta Murai, Kenji Monde, Setsuko Tsuboi, Takashi Jin
Bioconjugate Chemistry, 32, 8, 1541, 1547, 18 Aug. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, Recently, shortwave-infrared (SWIR) fluorescence imaging for the optical diagnostics of diseases has attracted much attention as a new noninvasive imaging modality. For this application, the development of SWIR molecular imaging probes with high biocompatibility is crucial. Although many types of biocompatible SWIR fluorescent probes based on organic dyes have been reported, there are no SWIR-emitting molecular imaging probes that can be used for the detection of specific biomolecules in vivo. To apply SWIR-emitting molecular imaging probes to biomedical fields, we developed a biocompatible SWIR fluorescent dye based on π-conjugation extended indocyanine green (ICG), where ICG is the only approved near-infrared dye by the US Food and Drug Administration (FDA) for use in the clinic. Using the π-conjugation extended ICG, we prepared SWIR molecular imaging probes that can be used for in vivo tumor imaging. Herein, we demonstrate noninvasive SWIR fluorescence imaging of human epidermal growth factor receptor 2 (HER2)-positive and epidermal growth factor receptor (EGFR)-positive breast tumors using π-conjugation extended ICG and monoclonal antibody conjugates. The presented π-conjugation extended ICG analog probes will be a breakthrough to apply SWIR fluorescence imaging in biomedical fields.

Daurichromenic acid from the Chinese traditional medicinal plant Rhododendron dauricum inhibits sphingomyelin synthase and Aβ aggregation　　　　　　　　　　　　　　　
Hadya Virupaksha Deepak, Mahadeva M. M. Swamy, Yuta Murai, Yoshiko Suga, Masaki Anetai, Takuro Yo, Masahiro Kuragano, Koji Uwai, Kiyotaka Tokuraku, Kenji Monde
Molecules, 25, 18, 4077, 4088, 07 Sep. 2020, [Peer-reviewed]

Determination of the absolute configurations and sensory properties of the enantiomers of a homologous series (C6-C10) of 2-mercapto-4-alkanones　　　　　　　　　　　　　　　
Christiane Kiske, Anja Devenie Riegel, Ronja Hopf, Anna Kvind, Iulia Poplacean, Tohru Taniguchi, Mahadeva M. M. Swamy, Kenji Monde, Wolfgang Eisenreich, Karl-Heinz Engel
J. Agric. Food Chem., 64, 4, 1187, 1196, 03 Jan. 2019, [Peer-reviewed]
Scientific journal

Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor　　　　　　　　　　　　　　　
Mahadeva M. M. Swamy, Yuta Murai, Yusuke Ohno, Akio Kihara, Susumu Mitsutake, Yasuyuki Igarashi, Jian Yu, Min Yao, Yoshiko Suga, Masaki Anetai, Kenji Monde
Chem. Commun., 54, 90, 12758, 12761, 08 Nov. 2018, [Peer-reviewed]
Scientific journal

Chemical and genetic rescue of an ep300 knockdown model for Rubinstein Taybi Syndrome in zebrafish　　　　　　　　　　　　　　　
Aswini Babu, Mageshi Kamaraj, Moumita Basu, Debanjan Mukherjee, Shruti Kapoor, Shashi Ranjan, Mahadeva M. M. Swamy, Stephanie Kaypee, Vinod Scaria, Tapas K. Kundu, Chetana Sachidanandan
Biochim. Biophys. Acta, 1864, 4, 1203, 1215, Apr. 2018, [Peer-reviewed]
Scientific journal

Inhibition of histone/lysine acetyltransferase activity kills CoCl2-treated and hypoxia-exposed gastric cancer cells and reduces their invasiveness　　　　　　　　　　　　　　　
Suvasmita Rath, Lopamudra Das, Shrikant Babanrao Kokate, Nilabh Ghosh, Pragyesh Dixi, Niranjan Rou, Shivaram P. Singh, Subhasis Chattopadhyay, Hassan Ashktorab, Duane T. Smoo, Mahadeva M. M. Swamy, Tapas K. Kundu, Sheila E. Crowe, Asima Bhattacharyya
Int. J. Biochem. Cell Biol., 82, 28, 40, Jan. 2017, [Peer-reviewed]
Scientific journal

Reducing molecular flexibility by cyclization for elucidation of absolute configuration by CD calculations: Daurichromenic acid　　　　　　　　　　　　　　　
Attila Mandi, Mahadeva M. M. Swamy, Tohru Taniguchi, Masaki Anetai, Kenji Monde
Chirality, 28, 6, 453, 459, Jun. 2016, [Peer-reviewed]
Scientific journal

Stereochemistry of a rhododaurichromanic acid derivative　　　　　　　　　　　　　　　
Mahadeva M. M. Swamy, Attila Mándi, Masaki Anetai, Kenji Monde
Nat. Prod. Commun., 11, 2, 193, 195, Feb. 2016, [Peer-reviewed]
Scientific journal

Hydrazinobenzoylcurcumin inhibits androgen receptor activity and growth of castration-resistant prostate cancer in mice　　　　　　　　　　　　　　　
Min Wu, Sahn-Ho Kim, Indrani Datta, Albert Levin, Gregory Dyson, Jing Li, Stephanie Kaypee, Mahadeva M. M. Swamy, Nilesh Gupta, Ho Jeong Kwon, Mani Menon, Tapas K. Kundu, G. Prem-Veer Reddy
Oncotarget, 6, 8, 6136, 6150, Mar. 2015, [Peer-reviewed]
Scientific journal

Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers　　　　　　　　　　　　　　　
Feng Li, Muthu K, Shanmugam, Kodappully Sivaraman Siveen, Fan Wang, Tina H. Ong, Ser Yue Loo, Mahadeva M. M. Swamy, Somnath Mandal, Alan Prem Kumar, Boon Cher Goh, Tapas Kundu, Kwang Seok Ahn, Ling Zhi Wang, Kam Man Hui, Gautam Sethi
Oncotarget, 6, 7, 5147, 5163, Mar. 2015, [Peer-reviewed]
Scientific journal

Naphthoquinone-mediated inhibition of lysine acetyltransferase KAT3B/p300, basis for non-toxic inhibitor synthesis　　　　　　　　　　　　　　　
Mohankrishna Dalvoy Vasudevarao, Pushpak Mizar, Sujata Kumari, Somnath Mandal, Soumik Siddhanta, Mahadeva M. M. Swamy, Stephanie Kaypee, Ravindra C Kodihalli, Amrita Banerjee, Chandrabhas Naryana, Dipak Dasgupta, Tapas K. Kundu
J. Biol. Chem., 289, 11, 7702, 7717, Mar. 2014, [Peer-reviewed]
Scientific journal

Garcinol and its role in chronic diseases　　　　　　　　　　　　　　　
Amit K. Behera, Mahadeva M. M. Swamy, Nagashayana, Tapas K. Kundu
Adv. Exp. Med. Biol., Sep. 2016

Complexes and shortwave-infrared fluorescent probes, manufacturing methods and thereof　　　　　　　　　　　　　　　
Patent right, Jin Takashi, M. M. Mahadeva Swamy, Monde Kenji, Murai Yuta, RIKEN, Hokkaido University
特願2021-041717, 2021

Daurichromenic acid, naturally occurring SMS inhibitor　　　　　　　　　　　　　　　
Patent right, Monde Kenji, Murai Yuta, M. M. Mahadeva Swamy, Hokkaido University
特願2017-236847, 2017

Ginkgolic acid, naturally occurring SMS inhibitor　　　　　　　　　　　　　　　
Patent right, Monde Kenji, Murai Yuta, M. M. Mahadeva Swamy, Hokkaido University
特願2017-236846, 2017