MAKANAHALLI MADEGOWDA MAHADEVA SWAMY (マカナハリ マデゴウダ マハデバ スワミイ)
先端生命科学研究院 | 助教 |
Last Updated :2024/12/03
■研究者基本情報
Researchmap個人ページ
ホームページURL
研究者番号
- 60830031
J-Global ID
■経歴
経歴
- 2022年04月 - 現在
Visiting scientist, RIKEN, 日本国 - 2022年03月 - 現在
Assistant professor, Faculty of Advanced Life Science, Hokkaido University, 日本国 - 2019年04月 - 2022年02月
Research scientist, RIKEN, 日本国 - 2018年05月 - 2019年01月
Academic researcher, Hokkaido University, 日本国 - 2012年05月 - 2014年08月
Research assistant, JNCASR, インド
学歴
■研究活動情報
受賞
論文
- Biocompatible and Water-Soluble Shortwave-Infrared (SWIR)-Emitting Cyanine-Based Fluorescent Probes for In Vivo Multiplexed Molecular Imaging
Mahadeva M. M. Swamy, Yuta Murai, Kenji Monde, Setsuko Tsuboi, Aravind K. Swamy, Takashi Jin
ACS Applied Materials & Interfaces, 16, 17253, 17266, American Chemical Society (ACS), 2024年04月01日, [査読有り]
英語, 研究論文(学術雑誌) - Stereochemistry‐activity relationship of ceramide‐induced exosome production to clear amyloid‐β in Alzheimer's disease
Mariam Abdelrasoul, Kohei Yuyama, Mahadeva M. M. Swamy, Yuta Murai, Kenji Monde
Chirality, 35, 9, 577, 585, 2023年04月, [査読有り]
研究論文(学術雑誌) - Stereochemistry of Sphingolipids in Ganglioside GM3 Enhances Recovery of Nervous Functionality
Sajeer Koolath, Yuta Murai, Tomoya Suzuki, Mahadeva M, M. Swamy, Seigo Usuki, Kenji Monde
ACS Med. Chem. Lett., in press, 9, 1237, 1241, American Chemical Society (ACS), 2023年, [査読有り]
英語, 研究論文(学術雑誌) - A near-infrared fluorescent long-chain fatty acid toward optical imaging of cardiac metabolism in living mice
Mahadeva M. M. Swamy, Mohamad Zarif Mohd, Zubir, Mutmainah, Setsuko Tsuboi, Yuta Murai, Kenji Monde, Ken-ichi Hiranoc, Takashi Jin
Analyst, 147, 19, 4206, 4212, 2022年08月, [査読有り]
研究論文(学術雑誌) - Shortwave-infrared (SWIR) emitting annexin V for high-contrast fluorescence molecular imaging of tumor apoptosis in living mice
Mahadeva M. M. Swamy, Setsuko Tsuboi, Yuta Murai, Kenji Monde, Takashi Jin
RSC Advances, 12, 30, 19632, 19639, 2022年06月, [査読有り]
英語, 研究論文(学術雑誌) - Shortwave-Infrared fluorescent molecular imaging probes based on π-conjugation extended indocyanine green
Mahadeva M. M. Swamy, Yuta Murai, Kenji Monde, Setsuko Tsuboi, Takashi Jin
Bioconjugate Chemistry, 32, 8, 1541, 1547, 2021年08月18日, [査読有り], [国際誌]
英語, 研究論文(学術雑誌), Recently, shortwave-infrared (SWIR) fluorescence imaging for the optical diagnostics of diseases has attracted much attention as a new noninvasive imaging modality. For this application, the development of SWIR molecular imaging probes with high biocompatibility is crucial. Although many types of biocompatible SWIR fluorescent probes based on organic dyes have been reported, there are no SWIR-emitting molecular imaging probes that can be used for the detection of specific biomolecules in vivo. To apply SWIR-emitting molecular imaging probes to biomedical fields, we developed a biocompatible SWIR fluorescent dye based on π-conjugation extended indocyanine green (ICG), where ICG is the only approved near-infrared dye by the US Food and Drug Administration (FDA) for use in the clinic. Using the π-conjugation extended ICG, we prepared SWIR molecular imaging probes that can be used for in vivo tumor imaging. Herein, we demonstrate noninvasive SWIR fluorescence imaging of human epidermal growth factor receptor 2 (HER2)-positive and epidermal growth factor receptor (EGFR)-positive breast tumors using π-conjugation extended ICG and monoclonal antibody conjugates. The presented π-conjugation extended ICG analog probes will be a breakthrough to apply SWIR fluorescence imaging in biomedical fields. - Daurichromenic acid from the Chinese traditional medicinal plant Rhododendron dauricum inhibits sphingomyelin synthase and Aβ aggregation
Hadya Virupaksha Deepak, Mahadeva M. M. Swamy, Yuta Murai, Yoshiko Suga, Masaki Anetai, Takuro Yo, Masahiro Kuragano, Koji Uwai, Kiyotaka Tokuraku, Kenji Monde
Molecules, 25, 18, 4077, 4088, 2020年09月07日, [査読有り] - Determination of the absolute configurations and sensory properties of the enantiomers of a homologous series (C6-C10) of 2-mercapto-4-alkanones
Christiane Kiske, Anja Devenie Riegel, Ronja Hopf, Anna Kvind, Iulia Poplacean, Tohru Taniguchi, Mahadeva M. M. Swamy, Kenji Monde, Wolfgang Eisenreich, Karl-Heinz Engel
J. Agric. Food Chem., 64, 4, 1187, 1196, 2019年01月03日, [査読有り]
研究論文(学術雑誌) - Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor
Mahadeva M. M. Swamy, Yuta Murai, Yusuke Ohno, Akio Kihara, Susumu Mitsutake, Yasuyuki Igarashi, Jian Yu, Min Yao, Yoshiko Suga, Masaki Anetai, Kenji Monde
Chem. Commun., 54, 90, 12758, 12761, 2018年11月08日, [査読有り]
研究論文(学術雑誌) - Chemical and genetic rescue of an ep300 knockdown model for Rubinstein Taybi Syndrome in zebrafish
Aswini Babu, Mageshi Kamaraj, Moumita Basu, Debanjan Mukherjee, Shruti Kapoor, Shashi Ranjan, Mahadeva M. M. Swamy, Stephanie Kaypee, Vinod Scaria, Tapas K. Kundu, Chetana Sachidanandan
Biochim. Biophys. Acta, 1864, 4, 1203, 1215, 2018年04月, [査読有り]
研究論文(学術雑誌) - Inhibition of histone/lysine acetyltransferase activity kills CoCl2-treated and hypoxia-exposed gastric cancer cells and reduces their invasiveness
Suvasmita Rath, Lopamudra Das, Shrikant Babanrao Kokate, Nilabh Ghosh, Pragyesh Dixi, Niranjan Rou, Shivaram P. Singh, Subhasis Chattopadhyay, Hassan Ashktorab, Duane T. Smoo, Mahadeva M. M. Swamy, Tapas K. Kundu, Sheila E. Crowe, Asima Bhattacharyya
Int. J. Biochem. Cell Biol., 82, 28, 40, 2017年01月, [査読有り]
研究論文(学術雑誌) - Reducing molecular flexibility by cyclization for elucidation of absolute configuration by CD calculations: Daurichromenic acid
Attila Mandi, Mahadeva M. M. Swamy, Tohru Taniguchi, Masaki Anetai, Kenji Monde
Chirality, 28, 6, 453, 459, 2016年06月, [査読有り]
研究論文(学術雑誌) - Stereochemistry of a rhododaurichromanic acid derivative
Mahadeva M. M. Swamy, Attila Mándi, Masaki Anetai, Kenji Monde
Nat. Prod. Commun., 11, 2, 193, 195, 2016年02月, [査読有り]
研究論文(学術雑誌) - Hydrazinobenzoylcurcumin inhibits androgen receptor activity and growth of castration-resistant prostate cancer in mice
Min Wu, Sahn-Ho Kim, Indrani Datta, Albert Levin, Gregory Dyson, Jing Li, Stephanie Kaypee, Mahadeva M. M. Swamy, Nilesh Gupta, Ho Jeong Kwon, Mani Menon, Tapas K. Kundu, G. Prem-Veer Reddy
Oncotarget, 6, 8, 6136, 6150, 2015年03月, [査読有り]
研究論文(学術雑誌) - Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
Feng Li, Muthu K, Shanmugam, Kodappully Sivaraman Siveen, Fan Wang, Tina H. Ong, Ser Yue Loo, Mahadeva M. M. Swamy, Somnath Mandal, Alan Prem Kumar, Boon Cher Goh, Tapas Kundu, Kwang Seok Ahn, Ling Zhi Wang, Kam Man Hui, Gautam Sethi
Oncotarget, 6, 7, 5147, 5163, 2015年03月, [査読有り]
研究論文(学術雑誌) - Naphthoquinone-mediated inhibition of lysine acetyltransferase KAT3B/p300, basis for non-toxic inhibitor synthesis
Mohankrishna Dalvoy Vasudevarao, Pushpak Mizar, Sujata Kumari, Somnath Mandal, Soumik Siddhanta, Mahadeva M. M. Swamy, Stephanie Kaypee, Ravindra C Kodihalli, Amrita Banerjee, Chandrabhas Naryana, Dipak Dasgupta, Tapas K. Kundu
J. Biol. Chem., 289, 11, 7702, 7717, 2014年03月, [査読有り]
研究論文(学術雑誌)
書籍等出版物
産業財産権
- Complexes and shortwave-infrared fluorescent probes, manufacturing methods and thereof
特許権, Jin Takashi, M. M. Mahadeva Swamy, Monde Kenji, Murai Yuta, RIKEN, Hokkaido University
特願2021-041717, 2021年 - Daurichromenic acid, naturally occurring SMS inhibitor
特許権, Monde Kenji, Murai Yuta, M. M. Mahadeva Swamy, Hokkaido University
特願2017-236847, 2017年 - Ginkgolic acid, naturally occurring SMS inhibitor
特許権, Monde Kenji, Murai Yuta, M. M. Mahadeva Swamy, Hokkaido University
特願2017-236846, 2017年