MAKANAHALLI MADEGOWDA MAHADEVA SWAMY (マカナハリ マデゴウダ マハデバ スワミイ)

先端生命科学研究院助教
Last Updated :2024/12/03

■研究者基本情報

Researchmap個人ページ

研究者番号

  • 60830031

研究キーワード

  • Organic synthesis
  • Fluorescent probes
  • Molecular imaging
  • Sphingolipids
  • Natural products

研究分野

  • ライフサイエンス, 生物有機化学

■経歴

経歴

  • 2022年04月 - 現在
    Visiting scientist, RIKEN, 日本国
  • 2022年03月 - 現在
    Assistant professor, Faculty of Advanced Life Science, Hokkaido University, 日本国
  • 2019年04月 - 2022年02月
    Research scientist, RIKEN, 日本国
  • 2018年05月 - 2019年01月
    Academic researcher, Hokkaido University, 日本国
  • 2012年05月 - 2014年08月
    Research assistant, JNCASR, インド

学歴

  • 2014年10月 - 2018年03月, Doctoral degree, Graduate School of Life Science, Hokkaido University, 日本国
  • 2009年07月 - 2011年06月, Master's degree, University of Mysore, インド
  • 2006年06月 - 2009年05月, Bachelor's degree, University of Mysore, インド

■研究活動情報

受賞

  • 2021年10月, Best poster award RIKEN BDR retreat-2021               
  • 2018年10月, Japan Student Services Organization (JASSO) scholarship award               
  • 2014年10月, Japan government MEXT scholarship award               

論文

  • Biocompatible and Water-Soluble Shortwave-Infrared (SWIR)-Emitting Cyanine-Based Fluorescent Probes for In Vivo Multiplexed Molecular Imaging
    Mahadeva M. M. Swamy, Yuta Murai, Kenji Monde, Setsuko Tsuboi, Aravind K. Swamy, Takashi Jin
    ACS Applied Materials & Interfaces, 16, 17253, 17266, American Chemical Society (ACS), 2024年04月01日, [査読有り]
    英語, 研究論文(学術雑誌)
  • Stereochemistry‐activity relationship of ceramide‐induced exosome production to clear amyloid‐β in Alzheimer's disease               
    Mariam Abdelrasoul, Kohei Yuyama, Mahadeva M. M. Swamy, Yuta Murai, Kenji Monde
    Chirality, 35, 9, 577, 585, 2023年04月, [査読有り]
    研究論文(学術雑誌)
  • Stereochemistry of Sphingolipids in Ganglioside GM3 Enhances Recovery of Nervous Functionality
    Sajeer Koolath, Yuta Murai, Tomoya Suzuki, Mahadeva M, M. Swamy, Seigo Usuki, Kenji Monde
    ACS Med. Chem. Lett., in press, 9, 1237, 1241, American Chemical Society (ACS), 2023年, [査読有り]
    英語, 研究論文(学術雑誌)
  • A near-infrared fluorescent long-chain fatty acid toward optical imaging of cardiac metabolism in living mice               
    Mahadeva M. M. Swamy, Mohamad Zarif Mohd, Zubir, Mutmainah, Setsuko Tsuboi, Yuta Murai, Kenji Monde, Ken-ichi Hiranoc, Takashi Jin
    Analyst, 147, 19, 4206, 4212, 2022年08月, [査読有り]
    研究論文(学術雑誌)
  • Shortwave-infrared (SWIR) emitting annexin V for high-contrast fluorescence molecular imaging of tumor apoptosis in living mice               
    Mahadeva M. M. Swamy, Setsuko Tsuboi, Yuta Murai, Kenji Monde, Takashi Jin
    RSC Advances, 12, 30, 19632, 19639, 2022年06月, [査読有り]
    英語, 研究論文(学術雑誌)
  • Shortwave-Infrared fluorescent molecular imaging probes based on π-conjugation extended indocyanine green
    Mahadeva M. M. Swamy, Yuta Murai, Kenji Monde, Setsuko Tsuboi, Takashi Jin
    Bioconjugate Chemistry, 32, 8, 1541, 1547, 2021年08月18日, [査読有り], [国際誌]
    英語, 研究論文(学術雑誌), Recently, shortwave-infrared (SWIR) fluorescence imaging for the optical diagnostics of diseases has attracted much attention as a new noninvasive imaging modality. For this application, the development of SWIR molecular imaging probes with high biocompatibility is crucial. Although many types of biocompatible SWIR fluorescent probes based on organic dyes have been reported, there are no SWIR-emitting molecular imaging probes that can be used for the detection of specific biomolecules in vivo. To apply SWIR-emitting molecular imaging probes to biomedical fields, we developed a biocompatible SWIR fluorescent dye based on π-conjugation extended indocyanine green (ICG), where ICG is the only approved near-infrared dye by the US Food and Drug Administration (FDA) for use in the clinic. Using the π-conjugation extended ICG, we prepared SWIR molecular imaging probes that can be used for in vivo tumor imaging. Herein, we demonstrate noninvasive SWIR fluorescence imaging of human epidermal growth factor receptor 2 (HER2)-positive and epidermal growth factor receptor (EGFR)-positive breast tumors using π-conjugation extended ICG and monoclonal antibody conjugates. The presented π-conjugation extended ICG analog probes will be a breakthrough to apply SWIR fluorescence imaging in biomedical fields.
  • Daurichromenic acid from the Chinese traditional medicinal plant Rhododendron dauricum inhibits sphingomyelin synthase and Aβ aggregation               
    Hadya Virupaksha Deepak, Mahadeva M. M. Swamy, Yuta Murai, Yoshiko Suga, Masaki Anetai, Takuro Yo, Masahiro Kuragano, Koji Uwai, Kiyotaka Tokuraku, Kenji Monde
    Molecules, 25, 18, 4077, 4088, 2020年09月07日, [査読有り]
  • Determination of the absolute configurations and sensory properties of the enantiomers of a homologous series (C6-C10) of 2-mercapto-4-alkanones               
    Christiane Kiske, Anja Devenie Riegel, Ronja Hopf, Anna Kvind, Iulia Poplacean, Tohru Taniguchi, Mahadeva M. M. Swamy, Kenji Monde, Wolfgang Eisenreich, Karl-Heinz Engel
    J. Agric. Food Chem., 64, 4, 1187, 1196, 2019年01月03日, [査読有り]
    研究論文(学術雑誌)
  • Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor               
    Mahadeva M. M. Swamy, Yuta Murai, Yusuke Ohno, Akio Kihara, Susumu Mitsutake, Yasuyuki Igarashi, Jian Yu, Min Yao, Yoshiko Suga, Masaki Anetai, Kenji Monde
    Chem. Commun., 54, 90, 12758, 12761, 2018年11月08日, [査読有り]
    研究論文(学術雑誌)
  • Chemical and genetic rescue of an ep300 knockdown model for Rubinstein Taybi Syndrome in zebrafish               
    Aswini Babu, Mageshi Kamaraj, Moumita Basu, Debanjan Mukherjee, Shruti Kapoor, Shashi Ranjan, Mahadeva M. M. Swamy, Stephanie Kaypee, Vinod Scaria, Tapas K. Kundu, Chetana Sachidanandan
    Biochim. Biophys. Acta, 1864, 4, 1203, 1215, 2018年04月, [査読有り]
    研究論文(学術雑誌)
  • Inhibition of histone/lysine acetyltransferase activity kills CoCl2-treated and hypoxia-exposed gastric cancer cells and reduces their invasiveness               
    Suvasmita Rath, Lopamudra Das, Shrikant Babanrao Kokate, Nilabh Ghosh, Pragyesh Dixi, Niranjan Rou, Shivaram P. Singh, Subhasis Chattopadhyay, Hassan Ashktorab, Duane T. Smoo, Mahadeva M. M. Swamy, Tapas K. Kundu, Sheila E. Crowe, Asima Bhattacharyya
    Int. J. Biochem. Cell Biol., 82, 28, 40, 2017年01月, [査読有り]
    研究論文(学術雑誌)
  • Reducing molecular flexibility by cyclization for elucidation of absolute configuration by CD calculations: Daurichromenic acid               
    Attila Mandi, Mahadeva M. M. Swamy, Tohru Taniguchi, Masaki Anetai, Kenji Monde
    Chirality, 28, 6, 453, 459, 2016年06月, [査読有り]
    研究論文(学術雑誌)
  • Stereochemistry of a rhododaurichromanic acid derivative               
    Mahadeva M. M. Swamy, Attila Mándi, Masaki Anetai, Kenji Monde
    Nat. Prod. Commun., 11, 2, 193, 195, 2016年02月, [査読有り]
    研究論文(学術雑誌)
  • Hydrazinobenzoylcurcumin inhibits androgen receptor activity and growth of castration-resistant prostate cancer in mice               
    Min Wu, Sahn-Ho Kim, Indrani Datta, Albert Levin, Gregory Dyson, Jing Li, Stephanie Kaypee, Mahadeva M. M. Swamy, Nilesh Gupta, Ho Jeong Kwon, Mani Menon, Tapas K. Kundu, G. Prem-Veer Reddy
    Oncotarget, 6, 8, 6136, 6150, 2015年03月, [査読有り]
    研究論文(学術雑誌)
  • Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers               
    Feng Li, Muthu K, Shanmugam, Kodappully Sivaraman Siveen, Fan Wang, Tina H. Ong, Ser Yue Loo, Mahadeva M. M. Swamy, Somnath Mandal, Alan Prem Kumar, Boon Cher Goh, Tapas Kundu, Kwang Seok Ahn, Ling Zhi Wang, Kam Man Hui, Gautam Sethi
    Oncotarget, 6, 7, 5147, 5163, 2015年03月, [査読有り]
    研究論文(学術雑誌)
  • Naphthoquinone-mediated inhibition of lysine acetyltransferase KAT3B/p300, basis for non-toxic inhibitor synthesis               
    Mohankrishna Dalvoy Vasudevarao, Pushpak Mizar, Sujata Kumari, Somnath Mandal, Soumik Siddhanta, Mahadeva M. M. Swamy, Stephanie Kaypee, Ravindra C Kodihalli, Amrita Banerjee, Chandrabhas Naryana, Dipak Dasgupta, Tapas K. Kundu
    J. Biol. Chem., 289, 11, 7702, 7717, 2014年03月, [査読有り]
    研究論文(学術雑誌)

書籍等出版物

  • Garcinol and its role in chronic diseases               
    Amit K. Behera, Mahadeva M. M. Swamy, Nagashayana, Tapas K. Kundu
    Adv. Exp. Med. Biol., 2016年09月

産業財産権

  • Complexes and shortwave-infrared fluorescent probes, manufacturing methods and thereof               
    特許権, Jin Takashi, M. M. Mahadeva Swamy, Monde Kenji, Murai Yuta, RIKEN, Hokkaido University
    特願2021-041717, 2021年
  • Daurichromenic acid, naturally occurring SMS inhibitor               
    特許権, Monde Kenji, Murai Yuta, M. M. Mahadeva Swamy, Hokkaido University
    特願2017-236847, 2017年
  • Ginkgolic acid, naturally occurring SMS inhibitor               
    特許権, Monde Kenji, Murai Yuta, M. M. Mahadeva Swamy, Hokkaido University
    特願2017-236846, 2017年

担当教育組織