Researcher basic information

• Doctor of Engineering, Tokyo Institute of Technology

• https://researchmap.jp/kuniharu_ijiro?lang=en

• https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901043026613212
• http://chem.es.hokudai.ac.jp/
• http://chem.es.hokudai.ac.jp/mdl/

• 200901043026613212

• 超分子化学

• Nanotechnology/Materials, Nanometer-scale chemistry

• Bachelor's degree program, School of Science
• Master's degree program, Graduate School of Life Science
• Doctoral (PhD) degree program, Graduate School of Life Science

Research activity information

• Feb. 2026, 公益社団法人高分子学会, 2025 Award for Outstanding Achievement in Polymer Science and Technology
  Development of Self‑Assembled Nanomaterials Based on Biopolymers and Gold Nanoparticles
  居城邦治
• Oct. 2018, 14th IUPAC International Conference on Novel Materials and their Synthesis, Distinguished Award 2018 for Novel Materials and their Synthesis
• Mar. 2018, 公益社団法人 日本化学会, 日本化学会学術賞
  刺激応答性金ナノ構造集積体の創製と応用
  居城 邦治
• Sep. 2016, 高分子学会, 高分子学会三菱化学賞
  バイオテンプレートを用いたナノ構造組織体の設計
  居城 邦治
• Feb. 2016, 北海道大学, 平成27年度教育総長賞
  居城 邦治
• May 2014, 公益社団法人 高分子学会, 高分子学会賞
  ハニカムフィルムの生産技術とその応用
  居城 邦治
• Nov. 2007, 日刊工業新聞社主催、ＮＥＤＯ共催、中小企業基盤整備機構特別協力, 第２回モノづくり連携大賞 モノづくり連携大賞
  北海道の地の利と人材を活かしたバイオとナノの連携プロジェクト―自己組織化ハニカム膜の製造技術と医療応用―
  Japan

• Polymer Brush Morphology-Directed Orientation and Arrangement of Gold Nanorod Arrays
  Yu Sekizawa; Shohei Shiomoto; Takuya Isono; Kenji Tajima; Masaru Tanaka; Toshifumi Satoh; Kuniharu Ijiro; Hideyuki Mitomo
  Chemistry of Materials, 38, 8, 4343, 4352, American Chemical Society (ACS), 07 Apr. 2026, [Peer-reviewed], [International Magazine]
  Scientific journal
• Thermo‐Responsive Surface Potential Modulation in Gold Nanoparticles Modified With Oligo(ethylene glycol) Derivatives
  Hideyuki Mitomo; Chie Takeuchi; Mio Nakamura; Erika Kurimoto; Kuniharu Ijiro
  Chemistry – A European Journal, 32, 22, e70942, Wiley, 26 Mar. 2026, [Peer-reviewed], [Last author], [International Magazine]
  Scientific journal, ABSTRACT
  
  Smart materials that alter their physical properties in response to external stimuli have attracted significant interest for a wide range of applications. Among them, temperature‐responsive materials operating near physiological temperatures are particularly promising for biomedical uses. Such materials are generally understood to undergo hydration–dehydration transitions upon temperature changes, leading to reversible switching between hydrophilic and hydrophobic states. While hydrophobic interactions play a central role in biological systems, the temperature‐dependent behavior of surface charge has remained largely unexplored. Here, we investigate the surface charge properties of temperature‐responsive gold nanoparticles coated with oligo(ethylene glycol) (OEG)‐based ligands. Despite the absence of intrinsic charged groups, these nanoparticles exhibit negative zeta potentials in neutral to alkaline environments. Notably, increasing temperature induces not only a hydrophilic‐to‐hydrophobic transition but also a concomitant increase in surface potential. The results suggest that hydroxide ions are adsorbed at lower temperatures and desorbed upon heating in association with ligand dehydration. This coupled transition provides new insight into dynamic regulation of nanomaterial interfacial properties and may enable stimulus‐responsive control of interactions in biological environments.
• Shape-Dependent Surface-Enhanced Raman Scattering under Modal Ultrastrong Coupling between Self-Assembled Gold Nanoparticles and Fabry–Pérot Cavities
  Zhiyu He; Xu Shi; Keiji Sasaki; Hiroaki Misawa; Kuniharu Ijiro; Hideyuki Mitomo
  ACS Applied Materials & Interfaces, 17, 51, 69645, 69658, American Chemical Society (ACS), 11 Dec. 2025, [Peer-reviewed], [International Magazine]
  Scientific journal
• Highly Sensitive and Quantitative Detection of microRNA-21 in Cells Using Bipedal DNA Walker-Based Ratiometric Fluorescent Sensor
  Wenting Wei; Han Lin; Kuniharu Ijiro; Hideyuki Mitomo
  Analytical Chemistry, 97, 44, 24616, 24624, American Chemical Society (ACS), 21 Oct. 2025, [Peer-reviewed], [International Magazine]
  Scientific journal
• Controlled Assembly of Gold Nanodiscs via DNA Hybridization: Tuning Plasmonic Coupling via Interparticle Gap Distance and Multimerization Degree
  Melda Taspika; Takehiro Yachi; Xu Shi; Daisuke Unabara; Tasuku Hamaguchi; Koji Yonekura; Yusuke Yonamine; Hideyuki Mitomo; Kuniharu Ijiro
  Langmuir, 41, 44, 28811, 28824, American Chemical Society (ACS), 17 Oct. 2025, [Peer-reviewed], [Last author], [International Magazine]
  Scientific journal
• Versatile Nanoparticle Capsule Formation With Enhanced Encapsulation Efficiency via Solute‐Induced Liquid–Liquid Phase Separation
  Takehiro Yachi; Honoka Watanabe; Rumi Niwa; Daisuke Unabara; Tasuku Hamaguchi; Yusuke Yonamine; Koji Yonekura; Kuniharu Ijiro; Hideyuki Mitomo
  Small, 21, 30, 2502573, Wiley, 07 May 2025, [Peer-reviewed], [International Magazine]
  Scientific journal, Abstract
  
  Nanoparticle capsules (NCs), capsule‐like structures composed of inorganic nanoparticles (NPs), hold great potential for diverse applications due to their structure‐driven functionality and the unique properties of the NPs. Despite advancements in NC formation methods, achieving both stable formation and efficient material encapsulation remains challenging. In this study, a simple and versatile method is developed for the formation of inorganic NCs. Inorganic NCs are formed from oligo(ethylene glycol) (OEG)‐modified inorganic NPs via self‐assembly at solute‐induced liquid–liquid interfaces. First, Au NCs are formed from OEG‐Au NPs. Their formation is confirmed by scanning transmission electron microscopic (STEM) and cryo‐electron tomographic (ET) observations. The resulting Au NCs exhibited high stability, uniform size, and precise tunability under various conditions. The method is further extended to magnetic Fe₃O₄ NPs, affording size‐controlled magnetic NCs, demonstrating broad applicability. Moreover, this approach enables the efficient encapsulation of various materials, including citrate‐capped Au NPs and DNA molecules, into inorganic NCs, affording >2000‐fold enrichment. This method paves the way for innovative application of inorganic NCs in drug delivery, nanoreactors, and beyond.
• Streamlining Bacterial Gene Regulation via Nucleic Acid Delivery with Gold Nanoclusters
  Qingsong Zhang; Xinyi Leng; Lin Peng; Hong Lin; Guanhua Xuan; Weiwei Zhang; Hideyuki Mitomo; Kuniharu Ijiro; Guoqing Wang
  Small, 21, 2411723, Wiley, 24 Feb. 2025, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, Abstract
  
  Delivery of exogenous nucleic acids (NAs) for gene regulation in bacteria, bypassing the barrier of the cell wall, is essential for advancing fundamental microbiology and genetic engineering, and the treatment of bacterial diseases. However, current methods that rely on electrical or chemical interventions are limited by their complexity, specialized expertise, and laboratory‐specific instrumentation. This study explores the capability of gold nanoclusters (AuNCs) as carriers for delivering small‐interfering RNA and antisense oligonucleotides into bacteria for targeted gene regulation while shielding them from degradation during transport. By enhancing the cytoplasmic membrane permeability, the AuNCs enable efficient internalization of NAs into both Gram‐positive and Gram‐negative bacteria while exerting negligible influence on bacterial activity. It is demonstrated that the rationally designed NAs can be released from the AuNCs within bacteria, enabling ~70% knockdown of mecA in Methicillin‐resistant Staphylococcus aureus (MRSA). This significantly reduces MRSA's antibiotic resistance and enhances oxacillin treatment efficacy. Furthermore, the successful silencing of ligA in Escherichia coli and pilQ in Pseudomonas aeruginosa highlights the broad adaptability of the approach across diverse bacterial species. The AuNCs‐based next‐generation NA delivery system has the potential to transform bacterial gene regulation—previously restricted to laboratory settings—into a versatile and scalable solution for real‐world application.
• Chiral Shape Engineering Combined with Bimetallic Nanostructures for High-Performance Plasmonic Sulfide Sensors
  Han Lin; Kuniharu Ijiro; Hideyuki Mitomo
  Chemistry of Materials, 37, 3, 1221, 1230, American Chemical Society (ACS), 03 Feb. 2025, [Peer-reviewed], [International Magazine]
  Scientific journal
• Evaluation method for proteoglycans using near-infrared spectroscopy
  Fumiya Nakamura; Tomoki Ikemizu; Miu Murao; Takashi Isoshima; Daiji Kobayashi; Hideyuki Mitomo; Kuniharu Ijiro; Hiromi Kimura-Suda
  Analytical Sciences, 41, 395, 401, Springer Science and Business Media LLC, 24 Jan. 2025, [Peer-reviewed], [International Magazine]
  Scientific journal
• Charge-dependent hierarchical self-assembling of fluorinated gold nanoclusters
  Yuki Saito; Duhong Sun; Hayato Kanai; Yasuhiro Ishida; Hideyuki Mitomo; Kuniharu Ijiro; Katsuaki Konishi
  Chemical Communications, 61, 7, 1383, 1386, Royal Society of Chemistry (RSC), Dec. 2024, [Peer-reviewed], [International Magazine]
  Scientific journal, The introduction of semifluorinated ligands on Au₂₅ cluster surface results in the formation of hierarchical fibrous nanoassemblies dependent on the inherent charge of the cluster units.
• Azophotoswitches containing thiazole, isothiazole, thiadiazole, and isothiadiazole
  Nusaiba Madappuram Cheruthu; P. K. Hashim; Saugata Sahu; Kiyonori Takahashi; Takayoshi Nakamura; Hideyuki Mitomo; Kuniharu Ijiro; Nobuyuki Tamaoki
  Organic and Biomolecular Chemistry, 23, 1, 207, 212, 06 Nov. 2024, [Peer-reviewed], [International Magazine]
  Scientific journal
• Plasmonic circular dichroism-based metal ion detection using gold nanorod-DNA complexes.
  Yali Shi; Satoshi Nakamura; Hideyuki Mitomo; Yusuke Yonamine; Guoqing Wang; Kuniharu Ijiro
  Chemical communications (Cambridge, England), 60, 82, 11794, 11797, 10 Oct. 2024, [Peer-reviewed], [Last author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, We report that complexes formed between gold nanorods (AuNRs) and metal-mediated DNA exhibit plasmonic circular dichroism (CD) signals up to ∼400 times stronger than the molecular CD signal of DNA. This substantial enhancement enables the detection of metal ions, offering a promising approach to analytical applications in chiral biochemistry.
• Ultrasensitive Surface-Enhanced Raman Scattering Platform for Protein Detection via Active Delivery to Nanogaps as a Hotspot
  Tianxu Gao; Takehiro Yachi; Xu Shi; Rina Sato; Chikara Sato; Yusuke Yonamine; Kiyoshi Kanie; Hiroaki Misawa; Kuniharu Ijiro; Hideyuki Mitomo
  ACS Nano, 18, 21593, 21606, American Chemical Society (ACS), 02 Aug. 2024, [Peer-reviewed], [International Magazine]
  Scientific journal
• Influence of Solvophobicity of Biphenol-Derived Small Surface Ligands on the Formation of Size-Controllable Gold Nanoparticle Vesicles
  Jinjian Wei; Ying Liu; Zhidi Miao; Liang Zhang; Zhihua Li; Yuqin Chen; Kuniharu Ijiro; Zhide Zhang
  Langmuir, 40, 32, 16783, 16790, American Chemical Society (ACS), 31 Jul. 2024, [Peer-reviewed], ［Internationally co-authored］
  Scientific journal
• Hierarchical Au Nanoflowers Formed in an Ionic Liquid/Water System for Bacterial Inhibition
  Huiling Yin; Qingsong Zhang; Shengchao Hu; Xun Sun; Lin Peng; Huijie Zhao; Qing Kong; Hideyuki Mitomo; Yasutaka Matsuo; Kuniharu Ijiro; Guoqing Wang
  ACS Applied Nano Materials, 7, 16998, 17008, 17 Jul. 2024, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Assembly/disassembly control of gold nanorods with uniform orientation on anionic polymer brush substrates
  Jingyan Yang; Yu Sekizawa; Xu Shi; Kuniharu Ijiro; Hideyuki Mitomo
  Bulletin of the Chemical Society of Japan, 97, 7, uoae073, 10 Jul. 2024, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Spatially Uniform and Quantitative Surface-Enhanced Raman Scattering under Modal Ultrastrong Coupling Beyond Nanostructure Homogeneity Limits
  Yoshiki Suganami; Tomoya Oshikiri; Hideyuki Mitomo; Keiji Sasaki; Yen En Liu; Xu Shi; Yasutaka Matsuo; Kuniharu Ijiro; Hiroaki Misawa
  ACS Nano, 18, 6, 4993, 5002, 13 Feb. 2024, [Peer-reviewed], [International Magazine]
  Scientific journal
• Dynamic Orientation Control of Gold Nanorods in Polymer Brushes by Their Thickness Changes for Plasmon Switching
  Yu Sekizawa; Yuka Hasegawa; Hideyuki Mitomo; Chisato Toyokawa; Yusuke Yonamine; Kuniharu Ijiro
  Advanced Materials Interfaces, 2301066, Wiley, 10 Jan. 2024, [Peer-reviewed], [Last author], [International Magazine]
  Scientific journal, Abstract
  
  Gold nanorods (AuNRs) have unique optical properties such as transverse and longitudinal localized surface plasmon resonance (T‐ and L‐LSPR). As the L‐LSPR absorption depends on the angle of the AuNRs to incident light and polarization, orientational control of AuNRs is a crucial issue. In spite of various techniques to control AuNR orientation, dynamic orientation tuning on a solid substrate remains challenging. Herein, dynamic changes are demonstrated in AuNR orientation in the anionic polymer (DNA) brushes via control of their thickness by salt concentration. AuNRs vertically align toward the substrates when their thickness exceeds the AuNR length. Once their thickness becomes shorter than the AuNR length, the attached AuNRs begin to tilt. The tilt reaches a maximum level close to horizontal when the thickness decreases to half that of the AuNR length. The dynamic control between the vertical (uniform) and tilted (random) orientation of the AuNRs showed not only absorption intensity changes in L‐LSPR but also the switching of side‐by‐side plasmon coupling. The polymer brush‐based system affords a novel platform for the stimuli‐responsive control of AuNR orientation on the substrates via changes in the thickness of polymer brushes for actively tunable plasmonic substrates.
• Fair surface modification with mixed alkanethiols on gold nanoparticles through minimal unfair ligand exchange
  KUN XIONG; Masaharu Nagayama; Kuniharu Ijiro; Hideyuki Mitomo
  Nanoscale Advances, 6, 18, 4583, 4590, 2024, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Size Segregation of Gold Nanoparticles into Bilayer-like Vesicular Assembly
  Jinjian Wei; Yi Yu; Yasutaka Matsuo; Liang Zhang; Hideyuki Mitomo; Yuqin Chen; Kuniharu Ijiro; Zhide Zhang
  Langmuir, 39, 49, 17939, 17946, American Chemical Society (ACS), 01 Dec. 2023, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  Scientific journal
• ヒメマスの椎骨における骨強度と骨質の椎骨位置依存性
  河本 千宙; 中居 豪佑; 堀内 秀与; 中村 郁哉; 弘中 翔大; 三友 秀之; 居城 邦治; 佐々木 直樹; 木村 廣美[須田]
  日本骨形態計測学会雑誌, 33, 1, 176, 176, 日本骨形態計測学会, May 2023, [Peer-reviewed], [Domestic magazines]
  Japanese, Scientific journal
• DNA-Functionalized Silver Nanoparticles in an Alcoholic Solvent for Environment-Dictated Multimodal Actuation
  Li Kong; Luyang Wang; Yali Shi; Lin Peng; Xingguo Liang; Guoqing Wang; Hideyuki Mitomo; Tohru Takarada; Kuniharu Ijiro; Mizuo Maeda
  ACS Applied Nano Materials, 5, 8, 10321, 10330, American Chemical Society ({ACS}), 26 Aug. 2022, [Peer-reviewed], [International Magazine]
  Scientific journal
• ベニザケ椎骨におけるミネラル代謝の可視化解析
  河本 千宙; 堀内 秀与; 中村 郁哉; 弘中 翔大; 三友 秀之; 居城 邦治; 木村 廣美[須田]
  日本骨代謝学会学術集会プログラム抄録集, 40回, 134, 134, (一社)日本骨代謝学会, Jul. 2022, [Domestic magazines]
  Japanese, Symposium
• Three-dimensional structure determination of gold nanotriangles in solution using X-ray free-electron laser single-particle analysis
  Miki Nakano; Osamu Miyashita; Yasumasa Joti; Akihiro Suzuki; Hideyuki Mitomo; Yoshiya Niida; Ying Yang; Hirokatsu Yumoto; Takahisa Koyama; Kensuke Tono; Haruhiko Ohashi; Makina Yabashi; Tetsuya Ishikawa; YOSHITAKA BESSHO; Kuniharu Ijiro; Yoshinori Nishino; Florence Tama
  Optica, Optica Publishing Group, 06 Jun. 2022, [Peer-reviewed], [International Magazine]
  Scientific journal
• ヒメマスとベニザケ幼魚,親魚の生息環境が各骨質,骨強度に及ぼす影響
  河本 千宙; 堀内 秀与; 中村 郁哉; 弘中 翔大; 三友 秀之; 居城 邦治; 木村 廣美[須田]
  日本骨形態計測学会雑誌, 32, 1, S191, S191, 日本骨形態計測学会, May 2022, [Peer-reviewed], [Domestic magazines]
  Japanese, Scientific journal
• Thermo-Responsive Silver Nanocube Assembled Films
  Hideyuki Mitomo; Chie Takeuchi; Ryo Sugiyama; Kaoru Tamada; Kuniharu Ijiro
  Bulletin of the Chemical Society of Japan, 95, 5, 771, 773, May 2022, [Peer-reviewed], [Last author], [International Magazine]
  Scientific journal
• Hysteresis in the Thermo-Responsive Assembly of Hexa(ethylene glycol) Derivative-Modified Gold Nanodiscs as an Effect of Shape
  Joshua Chidiebere Mba; Hideyuki Mitomo; Yusuke Yonamine; Guoqing Wang; Yasutaka Matsuo; Kuniharu Ijiro
  NANOMATERIALS, 12, 9, May 2022, [Peer-reviewed], [Last author], [International Magazine]
  English, Scientific journal
• Core-Gap-Shell Nanoparticles@Polyaniline with TunablePlasmonic Chiroptical Activities by pH and Electric Potential Dual Modulation
  Han Lin; Hideyuki Mitomo; Yusuke Yonamine; Zhiyong Guo; Kuniharu Ijiro
  CHEMISTRY OF MATERIALS, 34, 9, 4062, 4072, May 2022, [Peer-reviewed], [Last author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Self-assembly of Gold Nanorods into a Highly Ordered Sheet via Electrostatic Interactions with Double-stranded DNA
  Satoshi Nakamura; Hideyuki Mitomo; Shigeaki Suzuki; Yu Torii; Yu Sekizawa; Yusuke Yonamine; Kuniharu Ijiro
  CHEMISTRY LETTERS, 51, 5, 529, 532, May 2022, [Peer-reviewed], [Last author], [International Magazine]
  English, Scientific journal
• Visualization of DNA replication in single chromosome by stable isotope labeling.
  Kosuke Nagata; Ken-Ichi Bajo; Hideyuki Mitomo; Ryosuke Fujita; Ryota Uehara; Kuniharu Ijiro; Hisayoshi Yurimoto
  Cell structure and function, 46, 2, 95, 101, 25 Sep. 2021, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, Among the inheritance of cellular components during cell division, deoxyribonucleic acid (DNA) and its condensate (chromosome) are conventionally visualized using chemical tag-labeled nucleotide analogs. However, associated mutagenesis with nucleotide analogs in the visualization of chromosomes is cause for concern. This study investigated the efficiency of using stable isotope labels in visualizing the replicating cultured human cell-chromosomes, in the absence of analog labels, at a high spatial resolution of 100 nm. The distinct carbon isotope ratio between sister chromatids reflected the semi-conservative replication of individual DNA strands through cell cycles and suggested the renewal of histone molecules in daughter chromosomes. Thus, this study provides a new, powerful approach to trace and visualize cellular components with stable-isotope labeling.Key Words: stable isotope, chromosome replication, semi-conservative replication, imaging, mass spectrometry.
• Vesicle Formation by the Self-Assembly of Gold Nanoparticles Covered with Fluorinated Oligo(ethylene glycol)-Terminated Ligands and Its Stability in Aqueous Solution
  Jinjian Wei; Xiaoying Huang; Liang Zhang; Yuqin Chen; Kenichi Niikura; Hideyuki Mitomo; Kuniharu Ijiro; Zhide Zhang
  Langmuir, 37, 32, 9694, 9700, 17 Aug. 2021, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• ヒメマスおよびベニザケ椎骨の骨評価
  堀内 秀与; 弘中 翔大; 中村 郁哉; 河本 千宙; 松尾 保孝; 三友 秀之; 居城 邦治; 木村 廣美[須田]
  日本骨形態計測学会雑誌, 31, 2, S130, S130, 日本骨形態計測学会, Jun. 2021, [Domestic magazines]
  Japanese
• Molecular configuration-mediated thermo-responsiveness in oligo(ethylene glycol) derivatives attached on gold nanoparticles
  Kun Xiong; Hideyuki Mitomo; Xueming Su; Yier Shi; Yusuke Yonamine; Shin-ichiro Sato; Kuniharu Ijiro
  Nanoscale Advances, 3, 13, 3762, 3769, 26 Mar. 2021, [Peer-reviewed], [Last author], [International Magazine]
  English, Scientific journal
• Hierarchical growth of Au nanograss with intense built-in hotspots for plasmonic applications
  Yali Shi; Qian Li; Yao Zhang; Guoqing Wang; Yasutaka Matsuo; Xingguo Liang; Tohru Takarada; Kuniharu Ijiro; Mizuo Maeda
  JOURNAL OF MATERIALS CHEMISTRY C, 8, 45, 16073, 16082, Dec. 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• ステロイド性骨粗鬆症ラットの腰椎の骨質は、大腿骨の骨質に比べて緩やかに変化する
  中村 郁哉; 兼平 裕也; 佐藤 大; 藤田 諒; 長谷川 智香; 堀内 秀与; 枡谷 朋美; 太田 昌博; 高畑 雅彦; 居城 邦治; 網塚 憲生; 木村 廣美[須田]
  日本骨代謝学会学術集会プログラム抄録集, 38回, 145, 145, (一社)日本骨代謝学会, Oct. 2020, [Domestic magazines]
  Japanese, Symposium
• Micro-liquid enclosure array and its semi-automated assembling system for x-ray free-electron laser diffractive imaging of samples in solution
  Takashi Kimura; Akihiro Suzuki; Ying Yang; Yoshiya Niida; Akiko Nishioka; Masashi Takei; Jinjian Wei; Hideyuki Mitomo; Yasutaka Matsuo; Kenichi Niikura; Kuniharu Ijiro; Kensuke Tono; Makina Yabashi; Tetsuya Ishikawa; Tairo Oshima; Yoshitaka Bessho; Yasumasa Joti; Yoshinori Nishino
  Review of Scientific Instruments, 91, 8, 083706, 083706, AIP Publishing, 01 Aug. 2020, [Peer-reviewed], [International Magazine]
  Scientific journal
• Salt-triggered Active Plasmonic Systems Based on the Assembly/Disassembly of Gold Nanorods in a DNA Brush Layer on a Solid Substrate
  Satoshi Nakamura; Hideyuki Mitomo; Yusuke Yonamine; Kuniharu Ijiro
  Chemistry Letters, 49, 7, 749, 752, 05 Jul. 2020, [Peer-reviewed], [Last author]
  English, Scientific journal
• Intrahelical Interactions in an α-Helical Coiled Coil Determine the Structural Stability of Tropomyosin
  Ken-Ichi Sano; Tsubasa Yuki; Yuta Nomata; Norihisa Nakayama; Ryo Iida; Hideyuki Mitomo; Kuniharu Ijiro; Yoshihito Osada
  Biochemistry, 59, 23, 2194, 2202, 16 Jun. 2020, [Peer-reviewed]
  English, Scientific journal
• Reversible changes in the orientation of gold nanorod arrays on polymer brushes
  Yu Sekizawa; Hideyuki Mitomo; Mizuki Nihei; Satoshi Nakamura; Yusuke Yonamine; Akinori Kuzuya; Takehiko Wada; Kuniharu Ijiro
  Nanoscale Advances, 2, 9, 3798, 3803, 22 May 2020, [Peer-reviewed], [Last author]
  English, Scientific journal
• ステロイド性骨粗鬆症モデルラットにおける骨強度と骨密度および骨質の関係
  中村 郁哉; 佐藤 大; 藤田 諒; 長谷川 智香; 堀内 秀与; 桝谷 朋美; 太田 昌博; 高畑 雅彦; 居城 邦治; 網塚 憲生; 木村 廣美[須田]
  日本骨形態計測学会雑誌, 30, 1, S134, S134, 日本骨形態計測学会, May 2020
  Japanese
• Strategy for Finely Aligned Gold Nanorod Arrays Using Polymer Brushes as a Template
  Satoshi Nakamura; Hideyuki Mitomo; Yu Sekizawa; Takeshi Higuchi; Yasutaka Matsuo; Hiroshi Jinnai; Kuniharu Ijiro
  Langmuir, 36, 13, 3590, 3599, 07 Apr. 2020, [Peer-reviewed], [Last author]
  English, Scientific journal
• Correction to "DNA Brush-Directed Vertical Alignment of Extensive Gold Nanorod Arrays with Controlled Density".
  Satoshi Nakamura; Hideyuki Mitomo; Miho Aizawa; Takeharu Tani; Yasutaka Matsuo; Kenichi Niikura; Andrew Pike; Masayuki Naya; Atsushi Shishido; Kuniharu Ijiro
  ACS omega, 4, 15, 16701, 16701, 08 Oct. 2019, [Peer-reviewed], [International Magazine]
  English, [This corrects the article DOI: 10.1021/acsomega.7b00303.].
• Nanoscale uniformity in the active tuning of a plasmonic array by polymer gel volume change
  Satoru Hamajima; Hideyuki Mitomo; Takeharu Tani; Yasutaka Matsuo; Kenichi Niikura; Masayuki Naya; Kuniharu Ijiro
  Nanoscale Advances, 1, 5, 1731, 1739, Mar. 2019, [Peer-reviewed], [Last author]
  English, Scientific journal
• Self‐Priming Enzymatic Fabrication of Multiply Modified DNA
  Colette J. Whitfield; Rachel C. Little; Kasid Khan; Kuniharu Ijiro; Bernard A. Connolly; Eimer M. Tuite; Andrew R. Pike
  Chemistry – A European Journal, 24, 57, 15267, 15274, Wiley, 12 Oct. 2018, [Peer-reviewed]
  English, Scientific journal
• Size-Defined Cracked Vesicle Formation via Self-Assembly of Gold Nanoparticles Covered with Carboxylic Acid-Terminated Surface Ligands
  Jinjian Wei; Hideyuki Mitomo; Takeharu Tani; Yasutaka Matsuo; Kenichi Niikura; Masayuki Naya; Kuniharu Ijiro
  Langmuir, 34, 41, 12445, 12451, Sep. 2018, [Peer-reviewed]
  English, Scientific journal
• Two-Step Assembly of Thermoresponsive Gold Nanorods Coated with a Single Kind of Ligand
  Ryo Iida; Hideyuki Mitomo; Kenichi Niikura; Yasutaka Matsuo; Kuniharu Ijiro
  Small, 14, 14, 1704230, Wiley-VCH Verlag, 05 Apr. 2018, [Peer-reviewed]
  English, Scientific journal
• Shape-dependent adjuvanticity of nanoparticle-conjugated RNA adjuvants for intranasal inactivated influenza vaccines
  Taiyu Tazaki; Koshiro Tabata; Akira Ainai; Yuki Ohara; Shintaro Kobayashi; Takafumi Ninomiya; Yasuko Orba; Hideyuki Mitomo; Tetsuo Nakano; Hideki Hasegawa; Kuniharu Ijiro; Hirofumi Sawa; Tadaki Suzuki; Kenichi Niikura
  RSC Advances, 8, 30, 16527, 16536, Royal Society of Chemistry, 2018, [Peer-reviewed]
  English, Scientific journal
• Formation of Plasmonic Vesicles Through the Self-Assembly of Sugar-Terminated Fluorinated Oligo(ethylene glycol) Ligand-Tethered Gold Nanoparticles
  Jinjian Wei; Kenichi Niikura; Hideyuki Mitomo; Yasutaka Mastuo; Kuniharu Ijiro
  JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 17, 12, 9149, 9156, Dec. 2017, [Peer-reviewed]
  English, Scientific journal
• Metal nanoarchitecture fabrication using DNA as a biotemplate
  Kuniharu Ijiro; Hideyuki Mitomo
  POLYMER JOURNAL, 49, 12, 815, 824, Dec. 2017, [Peer-reviewed]
  English
• Preparation and Characterization of Double-Stranded DNA Brushes via Surface-Initiated Enzymatic Polymerization
  Hideyuki Mitomo; Satoshi Nakamura; Yasunobu Suzuki; Yasutaka Matsuo; Kenichi Niikura; Kuniharu Ijiro
  JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 17, 12, 8995, 9001, Dec. 2017, [Peer-reviewed]
  English, Scientific journal
• Island Growth in the Seed-Mediated Overgrowth of Monometallic Colloidal Nanostructures
  Guoqing Wang; Yiding Liu; Chuanbo Gao; Lei Guo; Miaofang Chi; Kuniharu Ijiro; Mizuo Maeda; Yadong Yin
  CHEM, 3, 4, 678, 690, Oct. 2017, [Peer-reviewed]
  English, Scientific journal
• pH-Responsive Coassembly of Oligo(ethylene glycol)-Coated Gold Nanoparticles with External Anionic Polymers via Hydrogen Bonding
  Yu Torii; Naotoshi Sugimura; Hideyuki Mitomo; Kenichi Niikura; Kuniharu Ijiro
  LANGMUIR, 33, 22, 5537, 5544, Jun. 2017, [Peer-reviewed]
  English, Scientific journal
• DNA Brush-Directed Vertical Alignment of Extensive Gold Nanorod Arrays with Controlled Density
  Satoshi Nakamura; Hideyuki Mitomo; Miho Aizawa; Takeharu Tani; Yasutaka Matsuo; Kenichi Niikura; Andrew Pike; Masayuki Naya; Atsushi Shishido; Kuniharu Ijiro
  ACS Omega, 2, 5, 2208, 2213, American Chemical Society, 31 May 2017, [Peer-reviewed]
  English, Scientific journal
• Efficient Cellular Protein Transduction Using a Coiled-coil Protein Carrier
  Ken-Ichi Sano; Kanako Iijima; Norihisa Nakayama; Kuniharu Ijiro; Yoshihito Osada
  CHEMISTRY LETTERS, 46, 5, 719, 721, May 2017, [Peer-reviewed]
  English, Scientific journal
• Reverse Size Dependences of the Cellular Uptake of Triangular and Spherical Gold Nanoparticles
  Katsuyuki Nambara; Kenichi Niikura; Hideyuki Mitomo; Takafumi Ninomiya; Chie Takeuchi; Jinjian Wei; Yasutaka Matsuo; Kuniharu Ijiro
  LANGMUIR, 32, 47, 12559, 12567, Nov. 2016, [Peer-reviewed]
  English, Scientific journal
• Thermoresponsive Assembly of Gold Nanoparticles Coated with Oligo(Ethylene Glycol) Ligands with an Alkyl Head
  Ryo Iida; Hideyuki Mitomo; Yasutaka Matsuo; Kenichi Niikura; Kuniharu Ijiro
  JOURNAL OF PHYSICAL CHEMISTRY C, 120, 29, 15846, 15854, Jul. 2016, [Peer-reviewed]
  English, Scientific journal
• Yolk/Shell Assembly of Gold Nanoparticles by Size Segregation in Solution
  Jinjian Wei; Kenichi Niikura; Takeshi Higuchi; Takashi Kimura; Hideyuki Mitomo; Hiroshi Jinnai; Yasumasa Joti; Yoshitaka Bessho; Yoshinori Nishino; Yasutaka Matsuo; Kuniharu Ijiro
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 138, 10, 3274, 3277, Mar. 2016, [Peer-reviewed]
  English, Scientific journal
• Active Gap SERS for the Sensitive Detection of Biomacromolecules with Plasmonic Nanostructures on Hydrogels
  Hideyuki Mitomo; Kenta Horie; Yasutaka Matsuo; Kenichi Niikura; Takeharu Tani; Masayuki Naya; Kuniharu Ijiro
  ADVANCED OPTICAL MATERIALS, 4, 2, 259, 263, Feb. 2016, [Peer-reviewed]
  English, Scientific journal
• Fabrication of a Novel Cell Culture System Using DNA-Grafted Substrates and DNase
  Hideyuki Mitomo; Asumi Eguchi; Yasunobu Suzuki; Yasutaka Matsuo; Kenichi Niikura; Kohji Nakazawa; Kuniharu Ijiro
  JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 12, 2, 286, 295, Feb. 2016, [Peer-reviewed]
  English, Scientific journal
• Self-Organization beyond the Molecule: Control of Nanoparticle Assemblies by Their Surface Properties and Their Functional Applications
  Hideyuki Mitomo; Kenichi Niikura; Kuniharu Ijiro
  KOBUNSHI RONBUNSHU, 73, 2, 147, 156, 2016, [Peer-reviewed]
  Japanese, Scientific journal
• High-yield halide-free synthesis of biocompatible Au nanoplates
  Guoqing Wang; Shengyang Tao; Yiding Liu; Lei Guo; Guohui Qin; Kuniharu Ijiro; Mizuo Maeda; Yadong Yin
  CHEMICAL COMMUNICATIONS, 52, 2, 398, 401, 2016, [Peer-reviewed]
  English, Scientific journal
• Noncationic Rigid and Anisotropic Coiled-Coil Proteins Exhibit Cell-Penetration Activity
  Norihisa Nakayama; Kyoji Hagiwara; Yoshihiro Ito; Kuniharu Ijiro; Yoshihito Osada; Ken-ichi Sano
  LANGMUIR, 31, 30, 8218, 8223, Aug. 2015, [Peer-reviewed]
  English, Scientific journal
• DNA-modulated photo-transformation of AgCl to silver nanoparticles: visiting the formation mechanism
  Guoqing Wang; Hideyuki Mitomo; Yasutaka Matsuo; Kenichi Niikura; Mizuo Maeda; Kuniharu Ijiro
  JOURNAL OF COLLOID AND INTERFACE SCIENCE, 452, 224, 234, Aug. 2015, [Peer-reviewed]
  English, Scientific journal
• Synthesis of Janus-Like Gold Nanoparticles with Hydrophilic/Hydrophobic Faces by Surface Ligand Exchange and Their Self-Assemblies in Water
  Ryo Iida; Hitoshi Kawamura; Kenichi Niikura; Takashi Kimura; Shota Sekiguchi; Yasumasa Joti; Yoshitaka Bessho; Hideyuki Mitomo; Yoshinori Nishino; Kuniharu Ijiro
  LANGMUIR, 31, 14, 4054, 4062, Apr. 2015, [Peer-reviewed]
  English, Scientific journal
• Superior Cell Penetration by a Rigid and Anisotropic Synthetic Protein
  Norihisa Nakayama; Kyoji Hagiwara; Yoshihiro Ito; Kuniharu Ijiro; Yoshihito Osada; Ken-Ichi Sano
  LANGMUIR, 31, 9, 2826, 2832, Mar. 2015, [Peer-reviewed]
  English, Scientific journal
• Enzymatic Synthesis of a DNA Triblock Copolymer that is Composed of Natural and Unnatural Nucleotides
  Hideyuki Mitomo; Yukie Watanabe; Yasutaka Matsuo; Kenichi Niikura; Kuniharu Ijiro
  CHEMISTRY-AN ASIAN JOURNAL, 10, 2, 455, 460, Feb. 2015, [Peer-reviewed]
  English, Scientific journal
• Encapsulation of a gold nanoparticle in a DNA origami container
  Akinori Kuzuya; Masafumi Kaino; Mirai Hashizume; Kazuki Matsumoto; Takeaki Uehara; Yasutaka Matsuo; Hideyuki Mitomo; Kenichi Niikura; Kuniharu Ijiro; Yuichi Ohya
  POLYMER JOURNAL, 47, 2, 177, 182, Feb. 2015, [Peer-reviewed]
  English, Scientific journal
• Nanoparticle-based biomimetic functional materials (Presentation Recording)
  Kuniharu Ijiro
  NANOBIOSYSTEMS: PROCESSING, CHARACTERIZATION, AND APPLICATIONS VIII, 9557, 2015, [Peer-reviewed]
  English, International conference proceedings
• Amphiphilic Gold Nanoparticles Displaying Flexible Bifurcated Ligands as a Carrier for siRNA Delivery into the Cell Cytosol
  Kenichi Niikura; Kenya Kobayashi; Chie Takeuchi; Naoki Fujitani; Shuko Takahara; Takafumi Ninomiya; Kyoji Hagiwara; Hideyuki Mitomo; Yoshihiro Ito; Yoshihito Osada; Kuniharu Ijiro
  ACS APPLIED MATERIALS & INTERFACES, 6, 24, 22146, 22154, Dec. 2014, [Peer-reviewed]
  English, Scientific journal
• 慢性腎臓病に伴う骨・ミネラル代謝異常(CKD-MBD)の骨質の解析
  木村–須田廣美; 金沢恭祐; 伊藤哲平; 日高公介; 植野秀俊; 居城邦治; 小林幸雄; 圦本尚義
  北海道骨粗鬆症研究会雑誌, 3, 2, 12, 14, Oct. 2014, [Peer-reviewed]
  Japanese, Scientific journal
• Surface engineering of nanoparticles for therapeutic applications
  Kenya Kobayashi; Jinjian Wei; Ryo Iida; Kuniharu Ijiro; Kenichi Niikura
  POLYMER JOURNAL, 46, 8, 460, 468, Aug. 2014, [Peer-reviewed]
  English, Scientific journal
• Chemically cross-linked microtubule assembly shows enhanced dynamic motions on kinesins
  Ryuzo Kawamura; Ken-Ichi Sano; Kuniharu Ijiro; Yoshihito Osada
  RSC ADVANCES, 4, 62, 32953, 32959, 2014, [Peer-reviewed]
  English, Scientific journal
• Enhanced cellular uptake of amphiphilic gold nanoparticles with ester functionality
  Kenya Kobayashi; Kenichi Niikura; Chie Takeuchi; Shota Sekiguchi; Takafumi Ninomiya; Kyoji Hagiwara; Hideyuki Mitomo; Yoshihiro Ito; Yoshihito Osada; Kuniharu Ijiro
  CHEMICAL COMMUNICATIONS, 50, 10, 1265, 1267, 2014, [Peer-reviewed]
  English, Scientific journal
• DNA-templated plasmonic Ag/AgCl nanostructures for molecular selective photocatalysis and photocatalytic inactivation of cancer cells
  Guoqing Wang; Hideyuki Mitomo; Yasutaka Matsuo; Naonobu Shimamoto; Kenichi Niikura; Kuniharu Ijiro
  Journal of Materials Chemistry B, 1, 43, 5899, 5907, 21 Dec. 2013, [Peer-reviewed]
  English, Scientific journal
• Water transport mechanism through open capillaries analyzed by direct surface modifications on biological surfaces
  Daisuke Ishii; Hiroko Horiguchi; Yuji Hirai; Hiroshi Yabu; Yasutaka Matsuo; Kuniharu Ijiro; Kaoru Tsujii; Tateo Shimozawa; Takahiko Hariyama; Masatsugu Shimomura
  SCIENTIFIC REPORTS, 3, 3024, Oct. 2013, [Peer-reviewed]
  English, Scientific journal
• 337-340 Preparation of triblock dna as a template for fabrication of nano-gap structures using sequence-selective metallization
  Hideyuki Mitomo; Yukie Watanabe; Yasutaka Matsuo; Kenichi Nidcura; Kuniharu Ijiro
  Kobunshi Ronbunshu, 70, 7, 337, 340, Jul. 2013, [Peer-reviewed]
  Japanese, Scientific journal
• Enhanced Photon Extraction from a Quantum Dot Induced by a Silver Microcolumnar Photon Reflector
  Hidekazu Kumano; Hideaki Nakajima; Hitoshi Iijima; Satoru Odashima; Yasuhiro Matsuo; Kuniharu Ijiro; Ikuo Suemune
  APPLIED PHYSICS EXPRESS, 6, 6, 062801, Jun. 2013, [Peer-reviewed]
  English, Scientific journal
• Gold Nanoparticles as a Vaccine Platform: Influence of Size and Shape on Immunological Responses in Vitro and in Vivo
  Kenichi Niikura; Tatsuya Matsunaga; Tadaki Suzuki; Shintaro Kobayashi; Hiroki Yamaguchi; Yasuko Orba; Akira Kawaguchi; Hideki Hasegawa; Kiichi Kajino; Takafumi Ninomiya; Kuniharu Ijiro; Hirofumi Sawa
  ACS NANO, 7, 5, 3926, 3938, May 2013, [Peer-reviewed]
  English, Scientific journal
• Sub-100 nm Gold Nanoparticle Vesicles as a Drug Delivery Carrier enabling Rapid Drug Release upon Light Irradiation
  Kenichi Niikura; Naoki Iyo; Yasutaka Matsuo; Hideyuki Mitomo; Kuniharu Ijiro
  ACS APPLIED MATERIALS & INTERFACES, 5, 9, 3900, 3907, May 2013, [Peer-reviewed]
  English, Scientific journal
• Virus-like particles with removable cyclodextrins enable glutathione-triggered drug release in cells
  Kenichi Niikura; Naotoshi Sugimura; Yusuke Musashi; Shintaro Mikuni; Yasutaka Matsuo; Shintaro Kobayashi; Keita Nagakawa; Shuko Takahara; Chie Takeuchi; Hirofumi Sawa; Masataka Kinjo; Kuniharu Ijiro
  Molecular BioSystems, 9, 3, 501, 507, Mar. 2013, [Peer-reviewed]
  English, Scientific journal
• Characterization of Bone Mineralization in a Rat Model of Chronic Kidney Disease
  Hiromi Kimura-Suda; Kyosuke Kanazawa; Sachio Kobayashi; Mieko Kuwahara; Teppei Ito; Naoya Sakamoto; Makoto Kajiwara; Hideyuki Yamato; Kuniharu Ijiro; Hisayoshi Yurimoto
  JOURNAL OF BONE AND MINERAL RESEARCH, 28, Feb. 2013, [Peer-reviewed]
  English
• Analysis of herbal medicine coptis by Surface Enhanced Raman scattering Spectroscopy
  Kyouji Honma; Yasutaka Matsuo; Kuniharu Ijiro; Hiromi Kimura-Suda
  Proc. of CIF’13 “Biomimetics, Photonics Sensing and Networks” Eds. O. Karthaus and M. Kawase, PWC Pub, 87, 89, 2013, [Peer-reviewed]
  English, International conference proceedings
• Studies on bone metabolism by using isotope microscopy, FTIR imaging, and micro-Raman spectroscopy
  Hiromi Kimura-Suda; Kajiwara Makoto; Sakamoto Naoya; Kobayashi Sachio; Ijiro Kuniharu; Yurimoto Hisayoshi; Yamato Hideyuki
  Journal of Oral Biosciences, 55, 2, 61, 65, Japanese Association for Oral Biology, 2013, [Peer-reviewed]
  English, Scientific journal
• Nanopattern Fabrication of Gold on Hydrogels and Application to Tunable Photonic Crystal
  Naonobu Shimamoto; Yoshito Tanaka; Hideyuki Mitomo; Ryuzo Kawamura; Kuniharu Ijiro; Keiji Sasaki; Yoshihito Osada
  ADVANCED MATERIALS, 24, 38, 5243, 5248, Oct. 2012, [Peer-reviewed]
  English, Scientific journal
• Sequence-Specific Metallization of Single Divalent DNA-Nanoparticle Conjugates: A Potential Route to Single-Electron Devices
  Guoqing Wang; Ayako Ishikawa; Asumi Eguchi; Yasunobu Suzuki; Shukichi Tanaka; Yasutaka Matsuo; Kenichi Niikura; Kuniharu Ijiro
  CHEMPLUSCHEM, 77, 7, 592, 597, Jul. 2012, [Peer-reviewed]
  English, Scientific journal
• Sequence-Specific Metallization of Single Divalent DNA-Nanoparticle Conjugates: A Potential Route to Single-Electron Devices
  Guoqing Wang; Ayako Ishikawa; Asumi Eguchi; Yasunobu Suzuki; Shukichi Tanaka; Yasutaka Matsuo; Kenichi Niikura; Kuniharu Ijiro
  CHEMPLUSCHEM, 77, 7, 592, 597, Jul. 2012, [Peer-reviewed]
  English, Scientific journal
• Gold Nanoparticles Coated with Semi-Fluorinated Oligo(ethylene glycol) Produce Sub-100 nm Nanoparticle Vesicles without Templates
  Kenichi Niikura; Naoki Iyo; Takeshi Higuchi; Takashi Nishio; Hiroshi Jinnai; Naoki Fujitani; Kuniharu Ijiro
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134, 18, 7632, 7635, May 2012, [Peer-reviewed]
  English, Scientific journal
• Hydrophilic Gold Nanoparticles Adaptable for Hydrophobic Solvents
  Shota Sekiguchi; Kenichi Niikura; Yasutaka Matsuo; Kuniharu Ijiro
  LANGMUIR, 28, 13, 5503, 5507, Apr. 2012, [Peer-reviewed]
  English, Scientific journal
• Hydrophilic Double-Network Polymers that Sustain High Mechanical Modulus under 80% Humidity
  Taiki Tominaga; Ken-Ichi Sano; Jun Kikuchi; Hideyuki Mitomo; Kuniharu Ijiro; Yoshihito Osada
  ACS MACRO LETTERS, 1, 3, 432, 434, Mar. 2012, [Peer-reviewed]
  English, Scientific journal
• Novel charge transport in DNA-templated nanowires
  Guoqing Wang; Hirofumi Tanaka; Liu Hong; Yasutaka Matsuo; Kenichi Niikura; Masuhiro Abe; Kazuhiko Matsumoto; Takuji Ogawa; Kuniharu Ijiro
  JOURNAL OF MATERIALS CHEMISTRY, 22, 27, 13691, 13697, 2012, [Peer-reviewed]
  English, Scientific journal
• Nuclear transport facilitated by the interaction between nuclear pores and carbohydrates
  Shota Sekiguchi; Kenichi Niikura; Yasutaka Matsuo; Shige H. Yoshimura; Kuniharu Ijiro
  RSC ADVANCES, 2, 4, 1656, 1662, 2012, [Peer-reviewed]
  English, Scientific journal
• Virus Capsid Coating of Gold Nanoparticles via Cysteine-Au Interactions and Their Effective Cellular Uptakes
  Keita Nagakawa; Kenichi Niikura; Tadaki Suzuki; Yasutaka Matsuo; Manabu Igarashi; Hirofumi Sawa; Kuniharu Ijiro
  CHEMISTRY LETTERS, 41, 1, 113, 115, Jan. 2012, [Peer-reviewed]
  English, Scientific journal
• Self-Repairing Filamentous Actin Hydrogel with Hierarchical Structure
  Ken-Ichi Sano; Ryuzo Kawamura; Taiki Tominaga; Naoko Oda; Kuniharu Ijiro; Yoshihito Osada
  BIOMACROMOLECULES, 12, 12, 4173, 4177, Dec. 2011, [Peer-reviewed]
  English, Scientific journal
• pH-Dependent Network Formation of Quantum Dots and Fluorescent Quenching by Au Nanoparticle Embedding
  Shota Sekiguchi; Kenichi Niikura; Naoki Iyo; Yasutaka Matsuo; Asumi Eguchi; Takakazu Nakabayashi; Nobuhiro Ohta; Kuniharu Ijiro
  ACS APPLIED MATERIALS & INTERFACES, 3, 11, 4169, 4173, Nov. 2011, [Peer-reviewed]
  English, Scientific journal
• Fabrication and Wettability Patterning of Nano-structured Silicon Surface by using Self-organized Polymer Structures
  Y. Hirai; H. Yabu; Y. Matsuo; K. Ijiro; M. Shimomura
  表面科学, 32, 7, 416, 421, Jul. 2011, [Peer-reviewed]
  Japanese, Scientific journal, 6796
• Improving in Vivo Hepatic Transfection Activity by Controlling Intracellular Trafficking: The Function of GALA and Maltotriose
  Hidetaka Akita; Tomoya Masuda; Takashi Nishio; Kenichi Niikura; Kuniharu Ijiro; Hideyoshi Harashima
  MOLECULAR PHARMACEUTICS, 8, 4, 1436, 1442, Jul. 2011, [Peer-reviewed]
  English, Scientific journal
• Thermoresponsive Microtubule Hydrogel with High Hierarchical Structure
  Ken-Ichi Sano; Ryuzo Kawamura; Taiki Tominaga; Hiromichi Nakagawa; Naoko Oda; Kuniharu Ijiro; Yoshihito Osada
  BIOMACROMOLECULES, 12, 5, 1409, 1413, May 2011, [Peer-reviewed]
  English, Scientific journal
• Artificial polymeric receptors on the cell surface promote the efficient cellular uptake of quantum dots
  Kenichi Niikura; Katsuyuki Nambara; Takaharu Okajima; Ryosuke Kamitani; Shin Aoki; Yasutaka Matsuo; Kuniharu Ijiro
  ORGANIC & BIOMOLECULAR CHEMISTRY, 9, 16, 5787, 5792, 2011, [Peer-reviewed]
  English, Scientific journal
• Inspiration from chemical photography: accelerated photoconversion of AgCl to functional silver nanoparticles mediated by DNA
  Guoqing Wang; Takashi Nishio; Masato Sato; Ayako Ishikawa; Katsuyuki Nambara; Keita Nagakawa; Yasutaka Matsuo; Kenichi Niikura; Kuniharu Ijiro
  CHEMICAL COMMUNICATIONS, 47, 33, 9426, 9428, 2011, [Peer-reviewed]
  English, Scientific journal
• 3J1458 Motility of chemically cross-linked microtubule network driven by kinesin(Bioengineering2,The 49th Annual Meeting of the Biophysical Society of Japan)
  Kawamura Ryuzo; Sano Ken-ichi; Tominaga Taiki; Oda Naoko; Ijiro Kuniharu; Osada Yoshihito
  Seibutsu Butsuri, 51, S143, The Biophysical Society of Japan General Incorporated Association, 2011
  English
• Artificial polymeric receptors on the cell surface promote the efficient cellular uptake of quantum dots
  Kenichi Niikura; Katsuyuki Nambara; Takaharu Okajima; Ryosuke Kamitani; Shin Aoki; Yasutaka Matsuo; Kuniharu Ijiro
  ORGANIC & BIOMOLECULAR CHEMISTRY, 9, 16, 5787, 5792, 2011, [Peer-reviewed]
  English, Scientific journal
• Inspiration from chemical photography: accelerated photoconversion of AgCl to functional silver nanoparticles mediated by DNA
  Guoqing Wang; Takashi Nishio; Masato Sato; Ayako Ishikawa; Katsuyuki Nambara; Keita Nagakawa; Yasutaka Matsuo; Kenichi Niikura; Kuniharu Ijiro
  CHEMICAL COMMUNICATIONS, 47, 33, 9426, 9428, 2011, [Peer-reviewed]
  English, Scientific journal
• Influence of Hydrophobic Structures on the Plasma Membrane Permeability of Lipidlike Molecules
  Kenichi Niikura; Katsuyuki Nambara; Takaharu Okajima; Yasutaka Matsuo; Kuniharu Ijiro
  LANGMUIR, 26, 12, 9170, 9175, Jun. 2010, [Peer-reviewed]
  English, Scientific journal
• Low pH-Triggered Model Drug Molecule Release from Virus-Like Particles
  Noriko Ohtake; Kenichi Niikura; Tadaki Suzuki; Keita Nagakawa; Shintaro Mikuni; Yasutaka Matsuo; Masataka Kinjo; Hirofumi Sawa; Kuniharu Ijiro
  CHEMBIOCHEM, 11, 7, 959, 962, May 2010, [Peer-reviewed]
  English, Scientific journal
• Self-assembled Hierarchic Structures of Metal-Molecule Hybrids for Sensing and Electronic Devices
  K. Ijiro; A. Tanaka; Y. Matsuo; Y. Hashimoto; K. Nagakawa; N. Ohtake; T. Suzuki; H. Sawa; K. Niikura
  ICEP 2010 Proceedings, 179, 184, May 2010, [Peer-reviewed]
  English, International conference proceedings
• Spontaneous Formation of Microwrinkles on Metal Microdot Arrays by Shrinkage of Thermal Shrinkable Substrate
  Hiroshi Yabu; Yasutaka Matsuo; Kuniharu Ijiro; Fumiaki Nishino; Toshihiko Takaki; Masahiro Kuwahara; Masatsugu Shimomura
  ACS APPLIED MATERIALS & INTERFACES, 2, 1, 23, 27, Jan. 2010, [Peer-reviewed]
  English, Scientific journal
• Self-lubricating nanoparticles: self-organization into 3D-superlattices during a fast drying process
  Takashi Nishio; Kenichi Niikura; Yasutaka Matsuo; Kuniharu Ijiro
  CHEMICAL COMMUNICATIONS, 46, 47, 8977, 8979, 2010, [Peer-reviewed]
  English, Scientific journal
• Preparation of Self-Organized Porous Polymer Masks for Si Dry Etching
  Yuji Hirai; Hiroshi Yabu; Yasutaka Matsuo; Kuniharu Ijiro; Masatsugu Shimomura
  NEW FRONTIERS IN MACROMOLECULAR SCIENCE, 295, 77, +, 2010, [Peer-reviewed]
  English, International conference proceedings
• Arrays of triangular shaped pincushions for SERS substrates prepared by using self-organization and vapor deposition
  Yuji Hirai; Hiroshi Yabu; Yasutaka Matsuo; Kuniharu Ijiro; Masatsugu Shimomura
  CHEMICAL COMMUNICATIONS, 46, 13, 2298, 2300, 2010, [Peer-reviewed]
  English, Scientific journal
• Response of Mesenchymal Stem Cells from Rat Adult Bone Marrow to Honeycomb-patterned Porous Polymer Films
  MORITA Yuka; YAMAMOTO Sadaaki; YABU Hiroshi; ITO Emiko; HONMOU Osamu; IJIRO Kuniharu; SHIMOMURA Masatsugu
  Hyomen Kagaku, 31, 8, 392, 399, The Surface Science Society of Japan, 2010
  Japanese, In order to address the question if the proliferative ability of MSCs is able to be enhanced by surface topology, mesenchymal stem cells from rat adult bone marrow (r-MSCs) were cultured on polystyrene and polybutadiene honeycomb films without cytokines for cell growth. SEM, AFM and time laps phase contrast imaging demonstrated the anomalous cellular adhesion morphology and division on the honeycomb films that have not been observed so far in vitro culture on 2 dimensional scaffolds.; r-MSCs did not spread at all keeping semispherical shape along culture and divided directly in the semispherical cell bodies. The proliferative ability on polystyrene honeycomb films was about 1.5 times higher than that on the control flat film and commercially available polystyrene culture plates, whereas the polybutadiene honeycomb films did not affect the proliferative ability. The polymer dependence of the proliferative ability might be ascribed to the stiffness of the honeycomb structure dependent on polymer. These results led us to the hypothesis that the polystyrene honeycomb films mimic the topography and stiffness of the niche for r-MSCs, inducing the characteristic cell shape and division which may be similar to those in vivo.
• 1P155 1D1505 Autonomous oscillation in mechanical property of actin gel(Muscle,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan)
  Kawamura Ryuzo; Sano Ken-Ichi; Tominaga Taiki; Ijiro Kuniharu; Osada Yoshihito
  Seibutsu Butsuri, 50, 2, S46, The Biophysical Society of Japan General Incorporated Association, 2010
  English
• 1P156 Reversible gel-sol transition of covalently cross-linked actin hydrogel(Muscle,The 48th Annual Meeting of the Biophysical Society of Japan)
  Sano Ken-Ichi; Kawamura Ryuzo; Tominaga Taiki; Oda Naoko; Ijiro Kuniharu; Osada Yoshihito
  Seibutsu Butsuri, 50, 2, S46, S47, The Biophysical Society of Japan General Incorporated Association, 2010
  English
• Arrays of triangular shaped pincushions for SERS substrates prepared by using self-organization and vapor deposition
  Yuji Hirai; Hiroshi Yabu; Yasutaka Matsuo; Kuniharu Ijiro; Masatsugu Shimomura
  CHEMICAL COMMUNICATIONS, 46, 13, 2298, 2300, 2010, [Peer-reviewed]
  English, Scientific journal
• Self-lubricating nanoparticles: self-organization into 3D-superlattices during a fast drying process
  Takashi Nishio; Kenichi Niikura; Yasutaka Matsuo; Kuniharu Ijiro
  CHEMICAL COMMUNICATIONS, 46, 47, 8977, 8979, 2010, [Peer-reviewed]
  English, Scientific journal
• Biomimetic bi-functional silicon nanospike-array structures prepared by using self-organized honeycomb templates and reactive ion etching
  Yuji Hirai; Hiroshi Yabu; Yasutaka Matsuo; Kuniharu Ijiro; Masatsugu Shimomura
  JOURNAL OF MATERIALS CHEMISTRY, 20, 48, 10804, 10808, 2010, [Peer-reviewed]
  English, Scientific journal
• Multivalent display of oligosaccharides on nanoparticles accelerates their nuclear import
  Kenichi Niikura; Kuniharu Ijiro; Shota Sekiguchi
  TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, 21, 122, 335, 344, Nov. 2009, [Peer-reviewed]
  English, Scientific journal
• Multivalent display of oligosaccharides on nanoparticles accelerates their nuclear import
  Kenichi Niikura; Kuniharu Ijiro; Shota Sekiguchi
  TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, 21, 122, 335, 344, Nov. 2009
  English
• Gold Nanoparticle Arrangement on Viral Particles through Carbohydrate Recognition: A Non-Cross-Linking Approach to Optical Virus Detection
  Kenichi Niikura; Keita Nagakawa; Noriko Ohtake; Tadaki Suzuki; Yasutaka Matsuo; Hirofumi Sawa; Kuniharu Ijiro
  BIOCONJUGATE CHEMISTRY, 20, 10, 1848, 1852, Oct. 2009, [Peer-reviewed]
  English, Scientific journal
• Envelope-type lipid nanoparticles incorporating a short PEG-lipid conjugate for improved control of intracellular trafficking and transgene transcription
  Tomoya Masuda; Hidetaka Akita; Kenichi Niikura; Takashi Nishio; Masami Ukawa; Kaoru Enoto; Radostin Danev; Kuniaki Nagayama; Kuniharu Ijiro; Hideyoshi Harashima
  BIOMATERIALS, 30, 27, 4806, 4814, Sep. 2009, [Peer-reviewed]
  English, Scientific journal
• Enhanced Accumulation of Carbohydrate-Displaying CdTe Quantum Dots in Cells Responding to Cellular Chemical Stresses
  Takashi Nishio; Kenichi Niikura; Yasutaka Mastuo; Kuniharu Ijiro
  International Journal of Nanoscience, 8, 1, 219, 222, Feb. 2009, [Peer-reviewed]
  English, Scientific journal
• Design of Cell-Surface-Retained Polymers for Artificial Ligand Display
  Ryosuke Kamitani; Kenichi Niikura; Takaharu Okajima; Yasutaka Matsuo; Kuniharu Ijiro
  CHEMBIOCHEM, 10, 2, 230, 233, Jan. 2009, [Peer-reviewed]
  English, Scientific journal
• 3P-267 Reversible 3D-crosslinked 'bio-hydrogel' by polymerizable proteins(Bioengineering,The 47th Annual Meeting of the Biophysical Society of Japan)
  Kunita Itsuki; Tominaga Taiki; Kawamura Ryuzo; Nakagawa Hiromichi; Oda Naoko; Tsukamoto Rikako; Ijiro Kuniharu; Sano Ken-Ichi; Osada Yoshihito
  Seibutsu Butsuri, 49, S195, The Biophysical Society of Japan General Incorporated Association, 2009
  English
• 3P-266 Thermo-reversible hydrogel formed by microtubules(Bioengineering,The 47th Annual Meeting of the Biophysical Society of Japan)
  Kawamura Ryuzo; Sano Ken-Ichi; Kunita Istuki; Tominaga Taiki; Oda Naoko; Ijiro Kuniharu; Osada Yoshihito
  Seibutsu Butsuri, 49, S195, The Biophysical Society of Japan General Incorporated Association, 2009
  English
• Interfacial tension governs the formation of self-organized honeycomb-patterned polymer films
  Yukako Fukuhira; Hiroshi Yabu; Kuniharu Ijiro; Masatsugu Shimomura
  SOFT MATTER, 5, 10, 2037, 2041, 2009, [Peer-reviewed]
  English, Scientific journal
• Fabrication of Novel Biocompatible Surfaces by Two-Photon Absorption Technique Using Femtosecond Laser
  Tanaka Masaru; Sato Hirokazu; Sasaya Yugo; Horinouchi Suguru; Hotta Jun-ichi; Matsuo Yasutaka; Ijiro Kuniharu; Sasaki Keiji; Shimomura Masatsugu
  MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 505, 457, 468, 2009, [Peer-reviewed]
• Preparation of Highly Oriented Nano-Pit Arrays by Thermal Shrinking of Honeycomb-Patterned Polymer Films
  Hiroshi Yabu; Ruokun Jia; Yasutaka Matsuo; Kuniharu Ijiro; Sada-aki Yamamoto; Fumiaki Nishino; Toshihiko Takaki; Masahiro Kuwahara; Masatsugu Shimomura
  ADVANCED MATERIALS, 20, 21, 4200, +, Nov. 2008, [Peer-reviewed]
  English, Scientific journal
• Oligosaccharide-Mediated Nuclear Transport of Nanoparticles
  Kenichi Niikura; Shota Sekiguchi; Takashi Nishio; Tomoya Masuda; Hidetaka Akita; Yasutaka Matsuo; Kentaro Kogure; Hideyoshi Harashima; Kuniharu Ijiro
  CHEMBIOCHEM, 9, 16, 2623, 2627, Nov. 2008, [Peer-reviewed]
  English, Scientific journal
• Stabilization of DNA multiassembly by addition of a phosphate group at the 5 '-sticky end
  Aya Tanaka; Yasutaka Matsuo; Kenichi Niikura; Kuniharu Ijiro
  CHEMISTRY LETTERS, 37, 7, 758, 759, Jul. 2008, [Peer-reviewed]
  English, Scientific journal
• Double-layered Metal Mesh Film Having a Limited Viewing Angle Property Prepared by Electroless Plating of Self-rganization Honeycomb Film
  H. Yabu; Y. Hirai; Y. Matsuo; K. Ijiro; M. Shimomura
  Macromolecular Symposia, 267, 100, 104, Jun. 2008, [Peer-reviewed]
  English, Scientific journal
• Sequence-specific control of azobenzene assemblies by molecular recognition of DNA
  Osamu Haruta; Yasutaka Matsuo; Yuichi Hashimoto; Kenichi Niikura; Kuniharu Ijiro
  LANGMUIR, 24, 6, 2618, 2624, Mar. 2008, [Peer-reviewed]
  English, Scientific journal
• Development of lipid particles targeted via sugar-lipid conjugates as novel nuclear gene delivery system
  Tomoya Masuda; Hidetaka Akita; Takashi Nishio; Kenichi Niikura; Kentaro Kogure; Kuniharu Ijiro; Hideyoshi Harashima
  BIOMATERIALS, 29, 6, 709, 723, Feb. 2008, [Peer-reviewed]
  English, Scientific journal
• Enhanced cellular uptake of virus-like particles through immobilization on a sialic acid-displaying solid surface
  Noriko Ohtake; Kenichi Niikura; Tadaki Suzuki; Keita Nagakawa; Hirofumi Sawa; Kuniharu Ijiro
  BIOCONJUGATE CHEMISTRY, 19, 2, 507, 515, Feb. 2008, [Peer-reviewed]
  English, Scientific journal
• Photo-induced fluorescence emission enhancement of azobenzene thin films
  Osamu Haruta; Yasutaka Matsuo; Kuniharu Ijiro
  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 313, 595, 599, Feb. 2008, [Peer-reviewed]
  English, Scientific journal
• Sequence-specifically platinum metal deposition on enzymatically synthesized DNA block copolymer
  Aya Tanaka; Yasutaka Matsuo; Yuichi Hashimoto; Kuniharu Ijiro
  CHEMICAL COMMUNICATIONS, 36, 4270, 4272, 2008, [Peer-reviewed]
  English, Scientific journal
• 自己組織化マイクロパターン高分子表面が創り出すバイオ界面
  山本貞明; 田中賢; 藪浩; 伊藤絵美子; 前田悠; 森田有香; 居城邦治; 下村政嗣
  表面, 46, 8, 393, 409, 2008
• Surfactant dependence on fabrication of ordered microporous film of poly(lactide)
  Yukako Fukuhira; Hiroaki Kaneko; Kuniharu Ijiro; Hiroshi Yabu; Masatsugu Shimomura
  8th World Biomaterials Congress 2008, 4, 2012, 2008
  English, International conference proceedings
• Sequence-specifically platinum metal deposition on enzymatically synthesized DNA block copolymer
  Aya Tanaka; Yasutaka Matsuo; Yuichi Hashimoto; Kuniharu Ijiro
  CHEMICAL COMMUNICATIONS, 2008, 36, 4270, 4272, 2008, [Peer-reviewed]
  English, Scientific journal
• Phase separation of aqueous poly(vinyl methyl ether) solutions induced by the photon pressure of a focused near-infrared laser beam
  Yasuyuk Tsuboi; Masayuki Nishino; Yasutaka Matsuo; Kuniharu Ijiro; Noboru Kitamura
  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 80, 10, 1926, 1931, Oct. 2007, [Peer-reviewed]
  English, Scientific journal
• Patterned immobilization of unprotected carbohydrates on an aminooxy polymer-grafted solid surface
  Ryosuke Kamitani; Kenichi Niikura; Tomohiro Onodera; Norimasa Iwasaki; Hideyuki Shimaoka; Kuniharu Ijiro
  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 80, 9, 1808, 1813, Sep. 2007, [Peer-reviewed]
  English, Scientific journal
• The Influence of Pore Size of a Honeycomb Film on Early Spreading Process of Endothelial Cells
  Sadaaki Yamamoto; Masaru Tanaka; Emiko Ito; Yuka Morita; Hiroshi Sunami; Kuniharu Ijiro; Masatsugu Shimomura
  Hyoumen Kagaku, 28, 8, 433, 439, The Surface Science Society of Japan, Aug. 2007, [Peer-reviewed]
  Japanese, Scientific journal, The mechanism that cells use to recognize micro-patterned topographies was clarified. First, 3D double-layer poly (ε-caprolactone) scaffolds equipped with honeycomb-patterned micro-pores ("honeycomb films") were prepared. Then, porcine aortic endothelial cells (PAECs) were cultured on these scaffolds for 1-6 h in serum-free medium. Finally, their initial spreading process was investigated by using AFM and confocal laser scanning microscopy. The attachment and spreading of PAECs on honeycomb films having either 6-or 16-μm pore diameters resulted in voids within the cell cytoplasm, which correspond with the size and location of the honeycomb micropores. The number of cells with this unique morphology decreased with increasing culture time. This dependence of morphology on film pore size and culture time suggests a spreading process of PAECs in which the cells spread trying to sense suitable sites to adhere. Using thick filopodia, the cells spread along the rim of the film and produced pores by close contact between two spreading filopodia. Evidently, these pores became filled in during culture, presumably as the cells began to reorganize their cytoplasma.
• Accumulation of O-GlcNAc-displaying CdTe quantum dots in cells in the presence of ATP
  Kenichi Niikura; Takashi Nishio; Hidetaka Akita; Yasutaka Matsuo; Ryosuke Kamitani; Kentaro Kogure; Hideyoshi Harashima; Kuniharu Ijiro
  CHEMBIOCHEM, 8, 4, 379, 384, Mar. 2007, [Peer-reviewed]
  English, Scientific journal
• Application of oligonucleotide as a template for the assembly of nucleoamphiphile bearing azobenzene at the air-water interface
  Osamu Haruta; Kuniharu Ijiro
  JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 7, 3, 734, 737, Mar. 2007, [Peer-reviewed]
  English, Scientific journal
• Immobilizing and stretching of poly(dG)-poly(dC) synthesized by Klenow fragment exo(-) on substrates by LB method
  Aya Tanaka; Yasutaka Matsuo; Kuniharu Ijiro
  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 284, 246, 249, Aug. 2006, [Peer-reviewed]
  English, Scientific journal
• Highly expansive DNA hydrogel films prepared with photocrosslinkable poly(vinyl alcohol)
  Noriko Ishizuka; Yuichi Hashimoto; Yasutaka Matsuo; Kuniharu Ijiro
  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 284, 440, 443, Aug. 2006, [Peer-reviewed]
  English, Scientific journal
• Circular arrangement of nucleoamphiphile containing azobenzene by using base pairing with cyclic oligonucleotide template at the air-water interface
  Osamu Haruta; Jin Nishida; Kuniharu Ijiro
  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 284, 326, 330, Aug. 2006, [Peer-reviewed]
  English, Scientific journal
• Stripe pattern formation of oligonucleotides by Langmuir-Blodgett method
  Yasutaka Matsuo; Kuniharu Ijiro
  INTERNATIONAL JOURNAL OF NANOSCIENCE, VOL 5, NO 6, 5, 6, 697, +, 2006, [Peer-reviewed]
  English, International conference proceedings
• DNA-based silver nanowires fabricated by electroless plating
  K Ijiro; Y Matsuo; Y Hashimoto
  MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 445, 207, 211, 2006, [Peer-reviewed]
  English, Scientific journal
• DNA-assisted preparation of Ag nanoparticle by photoreduction
  Kuniharu Ijiro; Yasutaka Matsuo; Masato Sato
  Polymer Preprints, Japan, 55, 2, 4985, 4986, 2006
  Japanese, International conference proceedings
• Preparation of cell transfection array by using virus-like capsules immobilized onto substrates
  Kenichi Niikura; Noriko Ishizuka; Kuniharu Ijiro
  Polymer Preprints, Japan, 55, 2, 4875, 2006
  Japanese, International conference proceedings
• Systhesis of DNA block copolymer by DNA polymerase and its single molecule observation
  Aya Tanaka; Yasutaka Matsuo; Kuniharu Ijiro
  Polymer Preprints, Japan, 55, 2, 5290, 5291, 2006
  Japanese, International conference proceedings
• Sugar-displaying quantum dots for cellular stress sensing
  Kenichi Niikura; Takashi Nishio; Yasutaka Matsuo; Hidetaka Akita; Kentaro Kogure; Hideyoshi Harashima; Kuniharu Ijiro
  Polymer Preprints, Japan, 55, 2, 5451, 5452, 2006
  Japanese, International conference proceedings
• Synthesis of monodispersed DMA polymers by DNA polymerase and their single molecule obserbation
  Aya Tanaka; Yasutaka Matsuo; Kuniharu Ijiro
  Polymer Preprints, Japan, 55, 1, 1880, 2006
  Japanese, International conference proceedings
• Preparation of metal nanoparticle by nucleic acid-assisted photoreduction
  Masato Sato; Yasutaka Matsuo; Kuniharu Ijiro
  Polymer Preprints, Japan, 55, 1, 2177, 2006
  Japanese, International conference proceedings
• High density sugar-displaying materials using the glycoblotting methods for cell patterning
  Ryosuke Kamitani; Kenichi Niikura; Tomohiro Onodera; Norimasa Iwasaki; Masataka Fumoto; Hideyuki Shimaoka; Kuniharu Ijiro; Shin-Ichiro Nishimura
  Polymer Preprints, Japan, 55, 1, 1895, 2006
  Japanese, International conference proceedings
• Formation of DNA nano-stripe patterns by the LB method
  Yasutaka Matsuo; Kuniharu Ijiro
  Polymer Preprints, Japan, 55, 1, 1301, 2006
  Japanese, International conference proceedings
• Synthesis of sugar-displaying quantum dots and their intracellular dynamics
  Takashi Nishio; Kenichi Niikura; Yasutaka Matsuo; Hidetaka Akita; Kentaro Kogure; Hideyoshi Harashima; Kuniharu Ijiro
  Polymer Preprints, Japan, 55, 1, 2145, 2006
  Japanese, International conference proceedings
• DNA-Based Silver Nanowires Fabricated by Electroless Plating
  IJIRO Kuniharu; MATSUO Yasutaka; HASHIMOTO Yuichi
  Mol Cryst Liq Cryst, 445, 497-501, 2006
  English
• Spontaneous formation of polymer nanoparticles by good-solvent evaporation as a nonequilibrium process
  H Yabu; T Higuchi; K Ijiro; M Shimomura
  CHAOS, 15, 4, 047505, Dec. 2005, [Peer-reviewed]
  English, Scientific journal
• Fabrication of Silver Nanowires based on DNA stretched by the LB Method
  Y. Hashimoto; Y. Matsuo; K. Ijiro
  Transactions of the Materials Research Society of Japan, 30, 671, 674, Sep. 2005, [Peer-reviewed]
  English, Scientific journal
• Fabrication of metal nanowires by electroless plating of DNA
  Kuniharu Ijiro; Yasutaka Matsuo; Yuichi Hashimoto
  e-Journal of Surface Science and Nanotechnology, 3, 82, 85, 03 Mar. 2005, [Peer-reviewed]
  English, International conference proceedings
• Stretching of single DNA molecules complexed with restriction endonuclease by Langmuir-Blodgett method
  Y Matsuo; K Ijiro; M Shimomura
  COLLOIDS AND SURFACES B-BIOINTERFACES, 40, 3-4, 123, 126, Feb. 2005, [Peer-reviewed]
  English, Scientific journal
• Fabrication of silver nanowires by selective electroless plating of DNA stretched using the LB method
  Y Hashimoto; Y Matsuo; K Ijiro
  CHEMISTRY LETTERS, 34, 1, 112, 113, Jan. 2005, [Peer-reviewed]
  English, Scientific journal
• High- expansive gel films prepared from photosensitive PVA and polyelectrolyte
  Noriko Ishizuka; Yuichi Hashimoto; Yasutaka Matsuo; Kuniharu Ijiro
  Polymer Preprints, Japan, 54, 1, 1777, 2005
  Japanese, International conference proceedings
• Oligonucleotide templated molecular arrangement of nucleobase amphiphiles at the air-water interface
  Osamu Haruta; Kuniharu Ijiro
  Polymer Preprints, Japan, 54, 2, 3887, 3888, 2005
  Japanese, International conference proceedings
• Fabrication of metallic nanonet by using DNA network pattern as template
  Masato Sato; Yuichi Hashimoto; Yasutaka Matsuo; Kuniharu Ijiro
  Polymer Preprints, Japan, 54, 1, 917, 2005
  Japanese, International conference proceedings
• Alignment of π conjugated luminescent polymers using stretched DNA molecules as a template
  Yasutaka Matsuo; Kuniharu Ijiro
  Polymer Preprints, Japan, 54, 1, 1662, 2005
  Japanese, International conference proceedings
• Synthesis of poly(dA)-poly(dT) from oligodeoxyribonucleotides having different lengths
  Aya Tanaka; Yasutaka Matsuo; Kuniharu Ijiro
  Polymer Preprints, Japan, 54, 1, 2298, 2005
  Japanese, International conference proceedings
• Spectroscopic analyses of specific interaction between nucleobase monolayer and oligonucleotide
  Osamu Haruta; Kuniharu Ijiro
  Polymer Preprints, Japan, 54, 1, 2306, 2005
  Japanese, International conference proceedings
• Two-dimensional alignment of DNA/polymer complex by using Langmuir-Blodgett method
  Yasutaka Matsuo; Kuniharu Ijiro
  Polymer Preprints, Japan, 54, 2, 4294, 4295, 2005
  Japanese, International conference proceedings
• Synthesis of sequence-designed long DNA by DNA polymerase
  Aya Tanaka; Yasutaka Matsuo; Kuniharu Ijiro
  Polymer Preprints, Japan, 54, 2, 5090, 5091, 2005
  Japanese, International conference proceedings
• Fabrication of metallic nanonet by electroless plating of DNA network pattern
  Masato Sato; Yuichi Hashimoto; Yasutaka Matsuo; Kuniharu Ijiro
  Polymer Preprints, Japan, 54, 2, 5104, 5105, 2005
  Japanese, International conference proceedings
• Neuron alignment on self-organized pattern by optical tweezers
  Monma F; Tsuruma A; Matsuo Y; Hotta J.-I; Tanaka M; Yamamoto S; Sasaki K; Ijiro K; Nakamura H; Shimomura M
  Polymer Preprints, Japan, 54, 1, 2233, 2005, [Peer-reviewed]
• Influence of substratum surface morphologies on the structure of extracellular matrix on a honeycomb film
  Yamamoto S; Sunami H; Tanaka M; Matsuo Y; Ijiro K; Yamashita S; Morita Y; Shimomura M
  Polymer Preprints, Japan, 54, 1, 887, 2005, [Peer-reviewed]
• Molecular Recognition in Langmuir Monolayers at the Air-Water Interface for the Purpose of Molecular Arrangement Control
  IJIRO Kuniharu
  J. Surf. Sci. Soc. Jpn., 25, 3, 124, 130, The Surface Science Society of Japan, 10 Mar. 2004
  Japanese, The phenomenon of molecular recognition including further function is common in nature. Host-guest complexation occurring at Langmuir monolayers has been investigated in detail similarly to molecular recognition in solutions. Langmuir monolayers at the air-water interface provide a unique environment for molecular recognition. Characteristic binding efficiency and selectivity of water-soluble substrates by specific pairing of hydrogen bonding have been found for functionalized monolayers at the air-water interface. Hydrogen bonding network formation between a functionalized monolayer and a substrate enables cleavage of the head group of an amphiphile forming the monolayer by hydrolysis of a C=C double bond that links the head group to the hydrophobic tail. Molecular organization termed "molecular recognition-directed self-assembly" has been demonstrated through complementary base-pairing in monolayers at the air-water interface. Controlling of molecular arrangement of nucleobase amphiphiles in Langmuir monolayers has been attempted by using complementary base-pairing with sequence-designed oligonucleotides as a molecular template. This unique molecular recognition should be useful for nanotechnology.
• Preparation of honeycomb-patterned polyimide films by self-organization
  H Yabu; M Tanaka; K Ijiro; M Shimomura
  LANGMUIR, 19, 15, 6297, 6300, Jul. 2003, [Peer-reviewed]
  English, Scientific journal
• DNA-mimetics: towards novel molecular devices having molecular information
  M Shimomura; R Mitamura; J Matsumoto; K Ijiro
  SYNTHETIC METALS, 133, 473, 475, Mar. 2003, [Peer-reviewed]
  English, Scientific journal
• Stretching of single DNA molecules by LB technique for restriction site mapping
  K. Ijiro; Y. Matsuo; M. Shimomura
  Nucleic Acids Research Supplement, 3, 47, 48, 2003, [Peer-reviewed]
  English, Scientific journal
• Stretching of single DNA molecules by Langmuir-Blodgett method
  Y Matsuo; K Ijiro; M Shimomura
  ASIANANO 2002, PROCEEDINGS, 321, 325, 2003, [Peer-reviewed]
  English, International conference proceedings
• Electric conductivity of nucleic acid polymer monolayer
  Y Hashimoto; K Ijiro; T Sawadaishi; M Shimomura
  ASIANANO 2002, PROCEEDINGS, 333, 337, 2003, [Peer-reviewed]
  English, International conference proceedings
• Molecular recognition of nucleobases attached to self-assembled monolayers detected by chemical force microscopy and quartz crystal microbalance
  H Sunami; K Ijiro; M Shimomura
  ASIANANO 2002, PROCEEDINGS, 293, 297, 2003, [Peer-reviewed]
  English, International conference proceedings
• Controlled aggregation of azobenzene based on DNA-mimetics at the air-water interface
  K Ijiro; J Matsumoto; M Morisue; M Shimomura
  ASIANANO 2002, PROCEEDINGS, 223, 227, 2003, [Peer-reviewed]
  English, International conference proceedings
• Circular arrangement of azobenzene chromophores in the nucleoamphiphile monolayer by base-pairing with cyclic DNA
  J Nishida; J Matsumoto; M Morisue; K Ijiro; M Shimomura
  ASIANANO 2002, PROCEEDINGS, 303, 307, 2003, [Peer-reviewed]
  English, International conference proceedings
• DNA-Based Molecular Handling in Self-Organized Monolayers
  K. Ijiro; Y. Matsuo; M. Shimomura
  Interface 2003, 79, 82, 2003, [Peer-reviewed]
  English
• Immobilization of Single DNA Molecules Complexed with Cationic Lipid Monolayers towards Novel Molecular Devices
  K. Ijiro; R. Mitamura; J. Matsumoto; K. Kago; R. Yoshitome; H. Matsuoka; H. Yamaoka; M. Shimomura
  Nanotechnology toward the Organic Photonics, 351, 358, May 2002
  English, International conference proceedings
• Base-pair mapping by chemical force microscopy on nucleobase self-assembled monolayers
  K Ijiro; H Sunami; K Arai; J Matsumoto; O Karthaus; S Kraemer; S Mittler; N Nishi; B Juskowiak; S Takenaka; W Knoll; M Shimomura
  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 198, 677, 682, Feb. 2002, [Peer-reviewed]
  English, Scientific journal
• Preparation of self-organized micro-patterned polymer films having cell adhesive Ligands
  J Nishida; KA Nishikawa; S Nishimura; S Wada; T Karino; T Nishikawa; K Ijiro; M Shimomura
  POLYMER JOURNAL, 34, 3, 166, 174, 2002, [Peer-reviewed]
  English, Scientific journal
• Electric conductivity of nucleic acid polymer monolayer
  Yuichi Hashimoto; Kuniharu Ijiro; Tetsuro Sawadaishi; Masatsugu Shimomura
  International Journal of Nanoscience, Vol 1, Nos 5 and 6, 1, 5-6, 707, 711, 2002, [Peer-reviewed]
  English, International conference proceedings
• Controlled aggregation of azobenzene based on DNA-mimetics at the air-water interface
  Kuniharu Ijiro; Jin Matsumoto; Mitsuhiko Morisue; Masatsugu Shimomura
  International Journal of Nanoscience, Vol 1, Nos 5 and 6, 1, 5-6, 597, 601, 2002, [Peer-reviewed]
  English, International conference proceedings
• Circular arrangement of azobenzene chromophores in the nucleoamphiphile monolayer, by base-pairing with cyclic DNA
  Jin Nishida; Jin Matsumoto; Mitsuhiko Morisue; Kuniharu Ijiro; Masatsugu Shimomura
  International Journal of Nanoscience, Vol 1, Nos 5 and 6, 1, 5-6, 677, 681, 2002, [Peer-reviewed]
  English, International conference proceedings
• Molecular Recognition of Nucleobeses Attached to Self-Assembled Monolayers Detected by Chemical Rrce Microscopy and Quartz Crystal
  H. Sunami; K. Ijiro; M. Shimomura
  International Journal of Nanoscience, 1, 5-6, 667, 671, 2002, [Peer-reviewed]
  English, Scientific journal
• Stretching of single dna molecules by langmuir-blodgett method
  Yasutaka Matsuo; Kuniharu Ijiro; Masatsugu Shimomura
  International Journal of Nanoscience, Vol 1, Nos 5 and 6, 1, 5-6, 695, 699, 2002, [Peer-reviewed]
  English, International conference proceedings
• Photo-conductivity measurements of single line structure of poly(3-hexylthiophen) patterned film in submicro-meter range by conducting atomic force micro scope
  Yuichi Hashimoto; Tetsurou Sawadaishi; Kuniharu Ijiro; Masatsugu Shimomura
  Kobunshi Ronbunshu, 59, 10, 651, 655, Society of Polymer Science, 2002
  Japanese, Scientific journal
• Molecular recognition of nucleobases attached to self-assembled monolayers detected by chemical force microscopy and quartz crystal microbalance
  Hiroshi Sunami; Kuniharu Ijiro; Masatsugu Shimomura
  International Journal of Nanoscience, Vol 1, Nos 5 and 6, 1, 5-6, 667, 671, 2002, [Peer-reviewed]
  English, International conference proceedings
• Photo-conductivity measurements of single line structure of poly(3-hexylthiophen) patterned film in submicro-meter range by conducting atomic force micro scope
  Y Hashimoto; T Sawadaishi; K Ijiro; M Shimomura
  KOBUNSHI RONBUNSHU, 59, 10, 651, 655, 2002, [Peer-reviewed]
  Japanese, Scientific journal
• Direct observation of bimodal amphiphilic surface structures of zeolite particles for a novel liquid-liquid phase boundary catalysis
  S Ikeda; H Nur; T Sawadaishi; K Ijiro; M Shimomura; B Ohtani
  LANGMUIR, 17, 26, 7976, 7979, Dec. 2001, [Peer-reviewed]
  English, Scientific journal
• Direct observation of bimodal amphiphilic surface structures of zeolite particles for a novel liquid-liquid phase boundary catalysis
  S Ikeda; H Nur; T Sawadaishi; K Ijiro; M Shimomura; B Ohtani
  LANGMUIR, 17, 26, 7976, 7979, Dec. 2001
  English
• A lipid-coated lipase as an efficient hydrolytic catalyst in the two-phase aqueous-organic system
  T Mori; S Kishimoto; K Ijiro; A Kobayashi; Y Okahata
  BIOTECHNOLOGY AND BIOENGINEERING, 76, 2, 157, 163, Sep. 2001, [Peer-reviewed]
  English, Scientific journal
• Molecular Assemblies Based on DNA-Mimetics: Effect of Monolayer Matrix on Photopolymerization of Diacetylene-containing Nucleobase monolayers
  Kuniharu Ijiro; Jin Matsumoto; Masatsugu Shimomura
  Studies in Surface Science and Catalysis, 132, 481, 484, Feb. 2001, [Peer-reviewed]
  English, International conference proceedings
• Photopolymerization of the diacetylene nucleobase monolayers controlled by triplex formation
  J Matsumoto; K Ijiro; M Shimomura
  MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 371, 33, 36, 2001, [Peer-reviewed]
  English, Scientific journal
• Fabrication and photoconductivity measurements of mesoscopic 2-D patterned DNA
  K Ijiro; T Sawadaishi; M Shimomura
  MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 371, 375, 378, 2001
  English, Scientific journal
• Two-Dimensional Nucleobase Self-Organization Supported by Base-Pairing and Stacking at the Air-Water Interface
  MORISUE M; IJIRO K; SHIMOMURA M
  Mol. Cryst. Liq. Crys., 371, 379, 382, 2001
• Two-dimensional patterning of nanoparticles using dissipative structures
  T Sawadaishi; K Ijiro; M Shimomura; Y Shiraishi; N Toshima; T Yonezawa; T Kunitake
  MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 371, 123, 126, 2001
  English, Scientific journal
• Nucleobase mapping of self-assembled monolayers by chemical force microscopy
  Hiroshi Sunami; Kuniharu Ijiro; Olaf Karthaus; Stephan Kraemer; Silvia Mittler; Wolfgang Knoll; Masatsugu Simomura
  Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 371, 151, 154, Taylor and Francis Inc., 2001
  English, Scientific journal
• Fine tuning of chromophore orientation due to hydrogen bond formation in nucleobase-terminated azobenzene monolayers
  Mitsuhiko Morisue; Kuniharu Ijiro; Masatsugu Shimomura
  Studies in Surface Science and Catalysis, 132, 549, 552, Elsevier Inc., 2001
  English, International conference proceedings
• 二次元DNA-mimeticsの鋳型光重合
  松本仁; 居城邦治; 下村政嗣
  光化学, 32, 1, 6, 2001, [Peer-reviewed]
  English, Scientific journal
• Nucleobase mapping of self-assembled monolayers by chemical force microscopy
  H Sunami; K Ijiro; O Karthaus; S Kraemer; S Mittler; W Knoll; M Simomura
  MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 371, 151, 154, 2001, [Peer-reviewed]
  English, Scientific journal
• Molecular recognition and photopolymerization of nucleobase monolayer containing diacetylene group at the air-water interface
  J Matsumoto; K Ijiro; M Shimomura
  CHEMISTRY LETTERS, 11, 1280, 1281, Nov. 2000
  English, Scientific journal
• Precursory Research
  IJIRO Kuniharu
  Kobunshi, 49, 11, 781, 781, The Society of Polymer Science, Japan, 01 Nov. 2000
  Japanese
• Adenine-uridine base pairing at the water-solid-interface
  M Weisser; J Kashammer; B Menges; J Matsumoto; F Nakamura; K Ijiro; M Shimomura; S Mittler
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 122, 1, 87, 95, Jan. 2000
  English, Scientific journal
• Direct in situ observation of a lipid monolayer-DNA complex at the air-water interface by X-ray reflectometry
  K Kago; H Matsuoka; R Yoshitome; H Yamaoka; K Ijiro; M Shimomura
  LANGMUIR, 15, 16, 5193, 5196, Aug. 1999
  English
• Effect of polynucleotides on fluorescence quenching in monolayers at the air-water interface
  K Ijiro; T Ikeda; M Shimomura
  MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 327, 45, 48, 1999
  English, Scientific journal
• Molecular recognition and monolayer formation of azobenzene-containing nucleobase amphiphile assisted by cis -> trans photoisomerization at the air-water interface
  M Morisue; H Nakamura; K Ijiro; M Shimomura
  MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 337, 457, +, 1999
  English, Scientific journal
• Preparation of DNA-based molecular assemblies by self-organization. From nanometer scale to mesoscopic scale
  M Shimomura; J Matsumoto; F Nakamura; T Ikeda; T Fukasawa; K Hasebe; T Sawadaishi; O Karthaus; K Ijiro
  POLYMER JOURNAL, 31, 11, 1115, 1120, 1999
  English, Scientific journal
• Relationship between surface morphology and electroabsorption spectrum of an oxacyanine chromophore in a mixed Langmuir-Blodgett film
  N Ohta; M Nakamura; Yamazaki, I
  LANGMUIR, 14, 21, 6226, 6230, Oct. 1998
  English, Scientific journal
• Construction of two-dimensional DNA-mimetics: supramolecular architecture with highly stacked base-pairs of amphiphilic adenine and thymine at the air-water interface
  F Nakamura; K Ijiro; M Shimomura
  THIN SOLID FILMS, 327, 603, 606, Aug. 1998
  English, Scientific journal
• Mesoscopic patterns of molecular aggregates on solid substrates
  N Maruyama; T Koito; J Nishida; T Sawadaishi; Cieren, X; K Ijiro; O Karthaus; M Shimomura
  THIN SOLID FILMS, 327, 854, 856, Aug. 1998
  English, Scientific journal
• Mesoscopic pattern formation of nanostructured polymer assemblies
  N Maruyama; O Karthaus; K Ijiro; M Shimomura; T Koito; S Nishimura; T Sawadaishi; N Nishi; S Tokura
  SUPRAMOLECULAR SCIENCE, 5, 3-4, 331, 336, Jul. 1998
  English, Scientific journal
• Aggregation of dendrimers with a photochromic dithienylethene core group on the mica surface-atomic force microscopic imaging
  J Hellmann; M Hamano; O Karthaus; K Ijiro; M Shimomura; M Irie
  JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS, 37, 7A, L816, L819, Jul. 1998
  English, Scientific journal
• Protein-DNA double and triple layers: Interaction of biotinylated DNA fragments with solid supported streptavidin layers
  K Ijiro; H Ringsdorf; E Birch-Hirschfeld; S Hoffmann; U Schilken; M Strube
  LANGMUIR, 14, 10, 2796, 2800, May 1998
  English, Scientific journal
• Organizations of two-dimensional DNA-mimetics at the air-water interface
  K Ijiro; F Nakamura; M Shimomura
  MOLECULAR RECOGNITION AND INCLUSION, 361, 364, 1998
  English, International conference proceedings
• Synthesis and self-organisation of new cyclodextrin amphiphile
  T Sukegawa; M Matsuda; SI Nishimura; M Shimomura; K Ijiro; O Karthaus
  MOLECULAR RECOGNITION AND INCLUSION, 519, 522, 1998
  English, International conference proceedings
• Photonic and Electronic Applications of Mesoscopic Polymer Assemblies
  Masatsugu Shimomura; Takeo Koito; Norihiko Maruyama; Keiko Arai; Jin Nishida; Lars Grasjoe; Olaf Karthaus; Kuniharu Ijiro
  MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 322, 305, 312, 1998, [Peer-reviewed]
  English, Scientific journal
• Photoinduced Electron Transfer in DNA Monolayers
  SHIMOMURA Masatsugu; IJIRO Kuniharu
  Kobunshi, 46, 5, 334, 334, The Society of Polymer Science, Japan, May 1997
  Japanese
• Two-dimensional DNA-mimetic molecular organizations at the air-water interface
  M Shimomura; F Nakamura; K Ijiro; H Taketsuna; M Tanaka; H Nakamura; K Hasebe
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 119, 9, 2341, 2342, Mar. 1997
  English, Scientific journal
• Mesoscopic Patterns of DNA-Amphiphile Complexes
  M. Shimomura; O. Karthaus; N. Maruyama; K. Ijiro; T. Sawadaishi; S. Tokura; N. Nishi
  Rep. Prog. Polym. Phys. Jpn., 40, 523, 524, 1997
• Monomolecular layers of diarylethene-containing dendrimers
  O Karthaus; K Ijiro; M Shimomura; J Hellmann; M Irie
  LANGMUIR, 12, 26, 6714, 6716, Dec. 1996, [Peer-reviewed]
  English, Scientific journal
• Chiral crystal formation of octadecylcytosine monolayer by complementary base paring
  M Shimomura; F Nakamura; K Ijiro; H Taketsuna; M Tanaka; H Nakamura; K Hasebe
  THIN SOLID FILMS, 284, 691, 693, Sep. 1996, [Peer-reviewed]
  English, Scientific journal
• DNA monolayers complexed with amphiphilic intercalator at the air-water interface
  K Ijiro; M Shimomura; M Tanaka; H Nakamura; K Hasebe
  THIN SOLID FILMS, 284, 780, 783, Sep. 1996, [Peer-reviewed]
  English, Scientific journal
• Tailoring of stacked pi-electron arrays from electron- and/or energy donor-acceptor molecules based on two-dimensional supramolecular assemblies
  M Shimomura; O Karthaus; K Ijiro
  SYNTHETIC METALS, 81, 2-3, 251, 257, Aug. 1996, [Peer-reviewed]
  English, Scientific journal
• Ordered self-assembly of nanosize polystyrene aggregates on mica
  O Karthaus; K Ijiro; M Shimomura
  CHEMISTRY LETTERS, 9, 821, 822, 1996, [Peer-reviewed]
  English, Scientific journal
• Construction of oriented π-electron arrays based on two-dimensional supramolecular organizates
  Masatsugu Shimomura; Olaf Karthaus; Kuniharu Ijiro
  Supramolecular Science, 3, 1-3, 61, 65, Butterworth-Heinemann Ltd, 1996, [Peer-reviewed]
  English, Scientific journal
• ENHANCING ENANTIOSELECTIVITY OF A LIPID-COATED LIPASE VIA IMPRINTING METHODS FOR ESTERIFICATION IN ORGANIC-SOLVENTS
  Y OKAHATA; A HATANO; K IJIRO
  TETRAHEDRON-ASYMMETRY, 6, 6, 1311, 1322, Jun. 1995, [Peer-reviewed]
  English, Scientific journal
• A LIPID-COATED LIPASE AS AN ENANTIOSELECTIVE ESTER SYNTHESIS CATALYST IN HOMOGENEOUS ORGANIC-SOLVENTS
  Y OKAHATA; Y FUJIMOTO; K IJIRO
  JOURNAL OF ORGANIC CHEMISTRY, 60, 7, 2244, 2250, Apr. 1995, [Peer-reviewed]
  English, Scientific journal
• SIMPLE TRANSPHOSPHATIDYLATION OF PHOSPHOLIPIDS CATALYZED BY A LIPID-COATED PHOSPHOLIPASE-D IN ORGANIC-SOLVENTS
  Y OKAHATA; K NIIKURA; K IJIRO
  JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1, 7, 919, 925, Apr. 1995, [Peer-reviewed]
  English, Scientific journal
• DETECTION OF INTERCALATION BEHAVIORS OF DYES IN DNAS USING A QUARTZ-CRYSTAL MICROBALANCE
  Y OKAHATA; Y MATSUZAKI; K IJIRO
  SENSORS AND ACTUATORS B-CHEMICAL, 13, 1-3, 380, 383, May 1993, [Peer-reviewed]
  English, Scientific journal
• A DNA-LIPID CAST FILM ON A QUARTZ-CRYSTAL MICROBALANCE AND DETECTION OF INTERCALATION BEHAVIORS OF DYE MOLECULES INTO DNAS IN AN AQUEOUS-SOLUTION .2.
  Y OKAHATA; K IJIRO; Y MATSUZAKI
  LANGMUIR, 9, 1, 19, 21, Jan. 1993, [Peer-reviewed]
  English, Scientific journal
• HYBRIDIZATION OF NUCLEIC-ACIDS IMMOBILIZED ON A QUARTZ CRYSTAL MICROBALANCE
  Y OKAHATA; Y MATSUNOBU; K IJIRO; M MUKAE; A MURAKAMI; K MAKINO
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 114, 21, 8299, 8300, Oct. 1992, [Peer-reviewed]
  English, Scientific journal
• PREPARATION OF A LIPID-COATED LIPASE AND CATALYSIS OF GLYCERIDE ESTER SYNTHESES IN HOMOGENEOUS ORGANIC-SOLVENTS
  Y OKAHATA; K IJIRO
  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 65, 9, 2411, 2420, Sep. 1992, [Peer-reviewed]
  English, Scientific journal
• A DNA LIPID COMPLEX SOLUBLE IN ORGANIC-SOLVENTS
  K IJIRO; Y OKAHATA
  JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 18, 18, 1339, 1341, Sep. 1992, [Peer-reviewed]
  English, Scientific journal
• FUNCTIONAL CAPSULE MEMBRANES .32. LIPASE-IMMOBILIZED CAPSULE MEMBRANES AS A REACTOR IN ESTER SYNTHESES AND HYDROLYZES IN ORGANIC-SOLVENTS
  K IJIRO; Y OKAHATA
  JOURNAL OF MEMBRANE SCIENCE, 59, 1, 101, 112, Jun. 1991, [Peer-reviewed]
  English, Scientific journal
• PREPARATIONS OF LANGMUIR-BLODGETT FILMS OF ENZYME LIPID COMPLEXES - A GLUCOSE SENSOR MEMBRANE
  Y OKAHATA; T TSURUTA; K IJIRO; K ARIGA
  THIN SOLID FILMS, 180, 65, 72, Nov. 1989, [Peer-reviewed]
  English, Scientific journal
• ENZYME-LIPID COMPLEX .3. LANGMUIR-BLODGETT FILMS OF AN ENZYME-LIPID COMPLEX FOR SENSOR MEMBRANES
  Y OKAHATA; T TSURUTA; K IJIRO; K ARIGA
  LANGMUIR, 4, 6, 1373, 1375, Nov. 1988, [Peer-reviewed]
  English, Scientific journal
• A LIPID-COATED LIPASE AS A NEW CATALYST FOR TRIGLYCERIDE SYNTHESIS IN ORGANIC-SOLVENTS
  Y OKAHATA; K IJIRO
  JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 20, 1392, 1394, Oct. 1988, [Peer-reviewed]
  English, Scientific journal
• LIPASE-LIPID COMPLEX AS A RESOLUTION CATALYST OF RACEMIC ALCOHOLS IN ORGANIC-SOLVENTS
  Y OKAHATA; Y FUJIMOTO; K IJIRO
  TETRAHEDRON LETTERS, 29, 40, 5133, 5134, 1988, [Peer-reviewed]
  English, Scientific journal
• FUNCTIONAL CAPSULE MEMBRANES .29. THERMOLYSIN-IMMOBILIZED CAPSULE MEMBRANES AS BIOREACTORS IN THE SYNTHESIS OF A DIPEPTIDE (PRECURSOR OF ASPARTAME) IN AN ORGANIC-SOLVENT
  Y OKAHATA; K IJIRO
  JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1, 1, 91, 96, Jan. 1988, [Peer-reviewed]
  English, Scientific journal

• Azophotoswitches containing thiazole, isothiazole, thiadiazole, and isothiadiazole (vol 23, pg 207, 2025)
  Nusaiba Madappuram Cheruthu; P. K. Hashim; Saugata Sahu; Kiyonori Takahashi; Takayoshi Nakamura; Hideyuki Mitomo; Kuniharu Ijiro; Nobuyuki Tamaoki, ORGANIC & BIOMOLECULAR CHEMISTRY, 23, 45, 10408, 10408, 19 Nov. 2025
  English, Others
• 安定同位体を標識とした染色体の高空間分解能質量イメージング
  永田康祐; 永田康祐; 馬上謙一; 三友秀之; 藤田龍介; 上原亮太; 上原亮太; 居城邦治; 圦本尚義, 日本生化学会大会(Web), 95th, 2022
• Orientation changes of gold nanorods depending on polymer brush structure
  関澤祐侑; 三友秀之; 与那嶺雄介; 磯野拓也; 田島健次; 佐藤敏文; 居城邦治, ナノ学会大会講演予稿集, 20th, 2022
• Non-origami DNA for functional nanostructures: From structural control to advanced applications
  Lan Zhang; Xingyi Ma; Guoqing Wang; Xingguo Liang; Hideyuki Mitomo; Andrew Pike; Andrew Houlton; Kuniharu Ijiro, Nano Today, 39, 101154, 101154, Aug. 2021, [Last author]
  English, Introduction scientific journal
• Controlled Nanostructures Fabricated by the Self-Assembly of Gold Nanoparticles via Simple Surface Modifications
  Hideyuki Mitomo; Kuniharu Ijiro, Bulletin of the Chemical Society of Japan, 94, 4, 1300, 1310, 15 Apr. 2021, [Last author]
  Japanese, Introduction scientific journal
• Assembly and Active Control of Nanoparticles using Polymer Brushes as a Scaffold
  Satoshi Nakamura; Hideyuki Mitomo; Kuniharu Ijiro, Chemistry Letters, 50, 2, 361, 370, 05 Feb. 2021, [Last author]
  English, Introduction scientific journal
• 金ナノ粒子自己組織化カプセルを用いたドラッグデリバリーシステムの開発
  三友秀之; 居城邦治, 週刊 医学のあゆみ, 275, 13, 1293, 12999, 26 Dec. 2020, [Last author]
  Japanese, Introduction scientific journal
• 安定同位体標識を用いた染色体中のDNA複製の可視化
  永田康祐; 馬上謙一; 三友秀之; 三友秀之; 藤田龍介; 上原亮太; 上原亮太; 居城邦治; 居城邦治; 圦本尚義, 日本分子生物学会年会プログラム・要旨集(Web), 43rd, 2020
• ハイドロゲル表面に固定化した金ナノドット間距離の動的変化のナノスケール評価
  濱島暁; 三友秀之; 居城邦治, The Bulletin of the Nano Science and Technology （ナノ学会会誌）, 18, 1, 1, 7, Sep. 2019, [Last author]
  Japanese, Introduction scientific journal
• DNAミメティクス
  三友秀之; 居城邦治, 日本画像学会誌, 53, 3, 199, 206, Jun. 2019, [Peer-reviewed]
  Japanese, Introduction scientific journal
• DNA固定化基板を足場としたロッド状金ナノ粒子の配向化
  三友秀之; 居城邦治, セラミックス, 53, 6, 407, 410, Jun. 2018, [Peer-reviewed]
  Japanese, Introduction scientific journal
• Development of pump‐probe coherent diffractive imaging technique using X‐ray Free electron laser
  SUZUKI Yoshiyuki; SUZUKI Akihiro; KIMURA Takashi; MITOMO Hideyuki; JOTI Yasumasa; BESSHO Yoshitaka; IJIRO Kuniharu; NISHINO Yoshinori, Abstracts. RIES-Hokudai International Symposium, 19th, 134‐135, 2018
  English
• ナノポア(ナノサイズの穴)を用いた単分子センシング
  居城邦治; 三友秀之, パリティ Parity, 31, 6, 23, 31, Jun. 2017
  Japanese, Introduction scientific journal
• X‐ray laser imaging of thermoresponsive gold nanoparticles in solution
  SUZUKI Akihiro; KIMURA Takashi; IIDA Ryo; MITOMO Hideyuki; JOTI Yasumasa; BESSHO Yoshitaka; NIIKURA Ken‐ichi; IJIRO Kuniharu; NISHINO Yoshinori, Abstracts. RIES-Hokudai International Symposium, 18th, 114‐115, 2017
  English
• Development of Nano-medicine Using RNA Interference
  萩原 恭二; 佐野 健一; 居城 邦治; 新倉 謙一; 阿部 洋; 伊藤 嘉浩, 化學工業, 67, 12, 941, 947, Dec. 2016
  小峰工業出版, Japanese
• 慢性腎臓病に伴う低回転骨の骨質解析
  浅井恵; 兼平裕也; 伊藤哲平; 屋代充; 園生智弘; 小林幸雄; 居城邦治; 圦本尚義; 重松隆; 木村(須田)廣美, 日本骨形態計測学会雑誌, 26, 1, S160, S160, 05 Jun. 2016
  日本骨形態計測学会, Japanese
• X線自由電子レーザーを用いた環境を制御したナノイメージング
  西野吉則; 木村隆志; WEI Jinjian; 飯田良; 新倉謙一; 三友秀之; 居城邦治; 城地保昌; 別所義隆, 高分子学会予稿集(CD-ROM), 64, 2, ROMBUNNO.1J17, 25 Aug. 2015
  Japanese
• Self-assembly of Gold Nanoparticles Inspired by Biomolecular Assembly
  新倉謙一; 三友秀之; 居城邦治, 化学工業, 66, 4, 300, 304, Apr. 2015
  小峰工業出版, Japanese, Introduction scientific journal
• 細胞透過性コイルドコイルタンパク質の構造安定性
  結城翼; 中山典久; 萩原恭二; 伊藤嘉浩; 居城邦治; 長田義仁; 佐野健一, 高分子学会予稿集(CD-ROM), 64, 2, 2015
• X‐ray Laser Diffraction In‐Solution Imaging Using Environmental Cell Array Chips with Graphene Windows
  TAKABATAKE Yuki; KIMURA Takashi; YAMAZAKI Kenji; MAEHARA Yosuke; WEI Jinjian; NIIKURA Kenichi; IJIRO Kuniharu; JOTI Yasumasa; BESSHO Yositaka; GOHARA Kazutoshi; NISHINO Yoshinori, Abstracts. RIES-Hokudai International Symposium, 16th, 81, 82, 2015
  English
• 両親媒性表面をもつ金ナノ粒子によるsiRNAの効率的細胞導入
  新倉謙一; 小林謙也; 竹内智恵; 二宮孝文; 高原周子; 藤谷直樹; 長田義仁; 伊藤嘉浩; 居城邦治, 高分子学会予稿集(CD-ROM), 63, 2, ROMBUNNO.2S13, 03 Sep. 2014
  Japanese
• DNAミメティクス
  三友秀之; 居城邦治, 日本画像学会誌, 53, 3, 199, 206, Jun. 2014
  Japanese, Introduction scientific journal
• 安定同位体を用いた慢性腎臓病におけるカルシウム代謝の可視化
  KIMURA(SUDA) HIROMI; ITO TEPPEI; KANAZAWA KYOSUKE; KOBAYASHI SACHIO; IJIRO KUNIHARU; YURIMOTO HISAYOSHI, 日本腎臓学会誌, 56, 3, 327, 327, 25 May 2014
  (一社)日本腎臓学会, Japanese
• Enhanced cellular uptake of amphiphilic gold nanoparticles bearing ester groups
  Kenya Kobayashi; Kenichi Niikura; Chie Takeuchi; Kyoji Hagiwara; Yoshihiro Ito; Yoshihito Osada; Kuniharu Ijiro, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 247, Mar. 2014
  English, Summary international conference
• Gold nanoparticle vesicles as a drug delivery carrier enabling rapid drug release upon light irradiation
  Kenichi Niikura; Naoki Iyo; Yasutaka Matsuo; Hideyuki Mitomo; Kuniharu Ijiro, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 247, Mar. 2014
  English, Summary international conference
• Single-stranded RNA selective permeation through nanopores in a virus capsule surface
  Naotoshi Sugimura; Kenichi Niikura; Kyoji Hagiwara; Chie Takeuchi; Hideyuki Mitomo; Kuniharu Ijiro, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 247, Mar. 2014
  English, Summary international conference
• Janus gold nanoparticles: Control of the phase separation of two surface ligands
  Ryo Iida; Kenichi Niikura; Shota Sekiguchi; Hideyuki Mitomo; Kuniharu Ijiro, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 247, Mar. 2014
  English, Summary international conference
• 細胞膜透過を目指したナノ粒子表面修飾リガンドの設計
  小林謙也; 新倉謙一; 竹内智恵; 田崎太悠; 萩原恭二; 伊藤嘉浩; 長田義仁; 居城邦治, 高分子学会医用高分子シンポジウム講演要旨集, 43rd, 2014
• RNase内包ウイルスカプセルの作製と内部でのRNA分解反応
  杉村尚俊; 新倉謙一; 萩原恭二; 三友秀之; 伊藤嘉浩; 澤洋文; 長田義仁; 居城邦治, 高分子学会予稿集(CD-ROM), 63, 1, 2014
• ウイルスカプセルの内部空間での配列特異的RNA分解反応
  杉村尚俊; 新倉謙一; 萩原恭二; 三友秀之; 澤洋文; 居城邦治, 高分子学会予稿集(CD-ROM), 63, 2, 2014
• 分子の形と固さに基づいた細胞透過性人工タンパク質担体の創製
  中山典久; 中山典久; 萩原恭二; 萩原恭二; 伊藤嘉浩; 居城邦治; 居城邦治; 長田義仁; 佐野健一; 佐野健一; 佐野健一, 日本分子生物学会年会プログラム・要旨集(Web), 37th, 2014
• 生物に学ぶ動的に色を変えるナノ構造材料
  三友秀之; 居城邦治, 工業材料, 61, 11, 40, 43, Nov. 2013
  日刊工業出版プロダクション ; 1955-, Japanese, Introduction scientific journal
• 金ナノ粒子ワクチンによる形状依存的なサイトカイン産生及び抗体誘導の評価
  松永達也; 新倉謙一; 鈴木忠樹; 小林進太郎; 山口宏樹; 大場靖子; 梶野喜一; 二宮孝文; 澤洋文; 居城邦治, 日本化学会講演予稿集, 93rd, 3, 2013
• 金ナノ粒子ワクチンのin vivo及びin vitroにおける形状依存的ワクチン活性の評価
  松永達也; 新倉謙一; 鈴木忠樹; 小林進太郎; 山口宏樹; 大場靖子; 川口晶; 長谷川; 梶野喜一; 二宮孝文; 澤洋文; 居城邦治, 高分子学会北海道支部研究発表会講演要旨集, 47th, 2013
• In vivoおよびin vitroにおける金ナノ粒子ワクチンの形状依存的な活性
  新倉謙一; 松永達也; 鈴木忠樹; 小林進太郎; 小林進太郎; 山口宏樹; 大場靖子; 川口晶; 長谷川秀樹; 梶野喜一; 二宮孝文; 澤洋文; 居城邦治, バイオ・高分子シンポジウム講演要旨集, 23rd, 2013
• ナノ粒子ワクチンのワクチン活性に及ぼす粒子形状およびサイズ効果
  新倉謙一; 松永達也; 鈴木忠樹; 小林進太郎; 山口宏樹; 大場靖子; 川口晶; 長谷川秀樹; 梶野喜一; 二宮孝文; 澤洋文; 居城邦治, 高分子学会予稿集(CD-ROM), 62, 2, 2013
• Amphiphilic nanoparticles bearing ester functionality and its effect on cellular uptake
  KOBAYASHI Kenya; NIIKURA Kenichi; TAKEUCHI Chie; HAGIWARA Kyoji; MITOMO Hideyuki; NINOMIYA Takahumi; ITO Yoshihiro; OSADA Yoshihito; IJIRO Kuniharu; IJIRO Kuniharu, Abstracts. RIES-Hokudai International Symposium, 14th, 2013
• エステル置換基を有する両親媒性ナノ粒子とその細胞内導入への効果
  小林謙也; 新倉謙一; 竹内智恵; 高原周子; 萩原恭二; 伊藤嘉浩; 長田義仁; 居城邦治, 高分子学会予稿集(CD-ROM), 62, 2, 2013
• 酵素内包ウイルスカプセルの作製と微小空間での酵素反応
  杉村尚俊; 新倉謙一; 萩原恭二; 三友秀之; 永井健治; 澤洋文; 居城邦治, 高分子学会予稿集(CD-ROM), 62, 2, 2013
• Biomimetic Materials in Imitation of Eye-Opening Colors from Nano-Structure in Nature
  MITOMO Hideyuki; SHIMAMOTO Naonobu; IJIRO Kuniharu, Jitsumu Hyomen Gijutsu, 64, 1, 9, 14, Jan. 2013
  The Surface Finishing Society of Japan, Japanese, Introduction scientific journal
• 自己組織化を利用した銀微細間隙の作製とSERS測定
  平井悠司; 平井悠司; 藪浩; 松尾保孝; 松尾保孝; 居城邦治; 居城邦治; 下村政嗣; 下村政嗣; 下村政嗣, 応用物理学会学術講演会講演予稿集(CD−ROM), 73rd, ROMBUNNO.13A-PB6-3, 27 Aug. 2012
  Japanese
• 広さでは負けない北海道支部
  居城 邦治, 高分子, 61, 7, 487, 487, 01 Jul. 2012
  Japanese
• 光でパターニングしたDNAブラシを用いたリフトオフ法の開発
  鈴木康修; 江口明日美; 松尾保孝; 松尾保孝; 新倉謙一; 新倉謙一; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 61, 1, ROMBUNNO.2J21, 15 May 2012
  Japanese
• Fabrication of nano- or micro-meter scale pattern on hydrogels
  SHIMAMOTO Naonobu; SHIMAMOTO Naonobu; MITOMO Hideyuki; MITOMO Hideyuki; KAWAMURA Ryu‐zo; KISHI Ryo‐ichi; TANAKA Yoshito; SASAKI Keiji; IJIRO Kuniharu; IJIRO Kuniharu; OSADA Yoshihito, 高分子学会予稿集(CD−ROM), 61, 1, ROMBUNNO.1M21, 15 May 2012
  English
• DNAブラシの光マイクロパターニングとデバイスへの応用
  鈴木康修; 江口明日美; 松尾保孝; 松尾保孝; 新倉謙一; 新倉謙一; 居城邦治; 居城邦治, 日本化学会講演予稿集, 92nd, 3, 823, 09 Mar. 2012
  Japanese
• Self-assembly of gold nanoparticles in solution and their plasmonic application
  Naoki Iyo; Kenichi Niikura; Takashi Nishio; Kuniharu Ijiro, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 243, Mar. 2012
  English, Summary international conference
• DNA-mediated photoconversion of AgCl to functional nanocrystals
  Guoqing Wang; Yasutaka Matsuo; Kenichi Niikura; Kuniharu Ijiro, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 243, Mar. 2012
  English, Summary international conference
• Glutathione-triggered drug release from virus capsules in cells
  Kenichi Niikura; Keita Nagakawa; Yusuke Musashi; Hirofumi Sawa; Masataka Kinjo; Kuniharu Ijiro, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 243, Mar. 2012
  English, Summary international conference
• Shape dependent immunogenicity of antigen-coated gold nanomaterials
  Tatsuya Matsunaga; Kenichi Niikura; Tadaki Suzuki; Shintaro Kobayashi; Hiroki Yamaguchi; Hirofumi Sawa; Kuniharu Ijiro, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 243, Mar. 2012
  English, Summary international conference
• 形状の異なる金ナノ粒子を用いた擬似ウイルス粒子の作成とワクチン活性の形状依存性
  松永達也; 新倉謙一; 鈴木忠樹; 小林進太郎; 山口宏樹; 澤洋文; 居城邦治, 日本DDS学会学術集会プログラム予稿集, 28th, 2012
• ヌクレアーゼによる細胞剥離を可能にするDNAブラシ細胞培養基材の開発
  江口明日美; 松尾保孝; 松尾保孝; 新倉謙一; 新倉謙一; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 60, 2 Disk1, ROMBUNNO.2V04, 13 Sep. 2011
  Japanese
• 多孔性無機微粒子によるゲルの物性制御
  三友秀之; 三友秀之; 佐野健一; 佐野健一; 居城邦治; 居城邦治; 長田義仁, 高分子学会予稿集(CD−ROM), 60, 2 Disk1, ROMBUNNO.2S03, 13 Sep. 2011
  Japanese
• ゲル表面への金属マイクロパターンの作製
  島本直伸; 島本直伸; 三友秀之; 三友秀之; 川村隆三; 川端邦明; 岸良一; 佐野健一; 佐野健一; 居城邦治; 居城邦治; 長田義仁, 高分子学会予稿集(CD−ROM), 60, 2 Disk1, ROMBUNNO.3PC069, 13 Sep. 2011
  Japanese
• 同位体顕微鏡,FTIRイメージング,顕微ラマン分光を用いた骨代謝に関する研究
  KIMURA(SUDA) HIROMI; KAJIHARA MAKOTO; SAKAMOTO NAOYA; KOBAYASHI SACHIO; IJIRO KUNIHARU; YURIMOTO HISAYOSHI; YAMATO HIDEYUKI, J Oral Biosci, 53, Supplement, 84, 84, 01 Sep. 2011
  (一社)歯科基礎医学会, Japanese
• 量子ドットの3次元ネットワークの作製
  関口翔太; 新倉謙一; 松尾保孝; 居城邦治, コロイドおよび界面化学討論会講演要旨集, 63rd, 228, 22 Aug. 2011
  Japanese
• Ag埋め込み半導体ピラー構造を用いた高効率光子発生源の作製と発光特性評価
  飯島仁史; 中島秀朗; 中島秀朗; 小田島聡; 小田島聡; 熊野英和; 西尾崇; 松尾保孝; 居城邦治; 末宗幾夫, 応用物理学会学術講演会講演予稿集(CD−ROM), 72nd, ROMBUNNO.31A-A-5, 16 Aug. 2011
  Japanese
• 赤外イメージングおよび元素イメージングによる生体組織の解析
  木村 須田 廣美; 桑原 三恵子; 日高 公介; 金沢 恭祐; 本間 教嗣; 坂内 堅二; 菅野 三喜男; 梶原 誠; 大西 晃宏; 小林 幸雄; 坂本 直哉; 居城 邦治; 圦本 尚義; 大和 英之, バイオイメージング, 20, 2, 95, 96, 10 Aug. 2011
  Japanese
• 赤外イメージングおよび元素イメージングによる生体組織の解析
  KIMURA(SUDA) HIROMI; KUWAHARA MIEKO; HIDAKA KOSUKE; KANAZAWA KYOSUKE; HONMA NORITSUGU; BANNAI KENJI; SUGANO MIKIO; KAJIHARA MAKOTO; ONISHI AKIHIRO; KOBAYASHI SACHIO; SAKAMOTO NAOYA; IJIRO KUNIHARU; YURIMOTO HISAYOSHI; YAMATO HIDEYUKI, バイオイメージング, 20, 2, 95, 96, 10 Aug. 2011
  日本バイオイメージング学会, Japanese
• Supramolecular Chemistry-Mimetic Nanoparticle Assembly
  NIIKURA Kenichi; IJIRO Kuniharu, 高分子, 60, 8, 531, 536, Aug. 2011, [Invited]
  高分子学会, Japanese, Introduction scientific journal
• 糖鎖認識を利用した金属ナノ粒子の集合化によるウイルス検出
  永川桂大; 新倉謙一; 野村尚生; 松尾保孝; 鈴木忠樹; 澤洋文; 居城邦治, バイオ・高分子シンポジウム講演要旨集, 21st, 29-30, 15 Jul. 2011
  Japanese
• DNAブラシ上での細胞培養とDNaseによる細胞剥離
  江口明日美; 松尾保孝; 新倉謙一; 居城邦治, バイオ・高分子シンポジウム講演要旨集, 21st, 57-58, 15 Jul. 2011
  Japanese
• ウイルス粒子の再集合における金属ナノ粒子内包条件の検討
  永川桂大; 新倉謙一; 鈴木忠樹; 松尾保孝; 澤洋文; 居城邦治, ナノ学会大会講演予稿集, 9th, 113, 02 Jun. 2011
  Japanese
• DNAブラシを固定化した細胞培養基材の作製
  江口明日美; 松尾保孝; 新倉謙一; 居城邦治; 松尾保孝; 新倉謙一; 居城邦治, 高分子学会予稿集(CD−ROM), 60, 1 Disk1, ROMBUNNO.1PF120, 10 May 2011
  Japanese
• 細胞膜修飾高分子を用いたガン細胞特異的な微粒子導入
  新倉謙一; 南原克行; 岡嶋孝治; 松尾保孝; 居城邦治, 日本化学会講演予稿集, 91st, 3, 717, 11 Mar. 2011
  Japanese
• ウイルス様ナノカプセルを包含した金ナノシェル型構造体の構築
  永川桂大; 野村尚生; 新倉謙一; 鈴木忠樹; 松尾保孝; 澤洋文; 居城邦治, 日本化学会講演予稿集, 91st, 3, 989, 11 Mar. 2011
  Japanese
• 剥離層を用いたAg埋め込み半導体ピラー構造の作製と発光特性評価
  飯島仁史; 和田雅樹; 中島秀朗; 井田惣太郎; 小田島聡; 小田島聡; 熊野英和; 熊野英和; 西尾崇; 松尾保孝; 居城邦治; 末宗幾夫; 末宗幾夫, 応用物理学関係連合講演会講演予稿集(CD−ROM), 58th, ROMBUNNO.24A-KS-1, 09 Mar. 2011
  Japanese
• 自己組織化高分子構造を用いた銀微細構造の作製とSERS測定
  平井悠司; 藪浩; 松尾保孝; 松尾保孝; 居城邦治; 居城邦治; 下村政嗣; 下村政嗣; 下村政嗣, 応用物理学関係連合講演会講演予稿集(CD−ROM), 58th, ROMBUNNO.26A-BK-2, 09 Mar. 2011
  Japanese
• ナノギャップ電極作製のためのDNAブロックコポリマー合成および塩基配列選択的な金属化
  渡辺雪江; 松尾保孝; 松尾保孝; 新倉謙一; 新倉謙一; 居城邦治; 居城邦治, 高分子学会北海道支部研究発表会講演要旨集, 45th, 33, 01 Feb. 2011
  Japanese
• 剥離層を用いた金属埋め込み半導体ピラー構造の作製と光学評価
  飯島仁史; 和田雅樹; 中島秀朗; 井田惣太郎; 小田島聡; 小田島聡; 熊野英和; 熊野英和; 西尾崇; 松尾保孝; 居城邦治; 末宗幾夫; 末宗幾夫, 応用物理学会北海道支部・日本光学会北海道地区合同学術講演会講演予稿集, 46th-7th, 32, 07 Jan. 2011
  Japanese
• Thin film micro grating on hydro-gels for fine measurement
  SHIMAMOTO Naonobu; SHIMAMOTO Naonobu; MITOMO Hideyuki; MITOMO Hideyuki; KAWAMURA Ryuzo; OSADA Yoshihito; IJIRO Kuniharu; IJIRO Kuniharu, Abstr RIES Hokudai Symp, 12th, 144-145, 2011
  English
• 自己組織化微細構造を用いた超撥水‐超親水パターン化表面の作製
  平井悠司; 藪浩; 松尾保孝; 松尾保孝; 居城邦治; 居城邦治; 下村政嗣; 下村政嗣; 下村政嗣, 表面科学学術講演会講演要旨集, 30th, 418, 04 Nov. 2010
  Japanese
• 自己組織化によるバイオミメティックサーフェスの作製と機能
  下村政嗣; 下村政嗣; 平井悠司; 石井大祐; 藪浩; 松尾保孝; 居城邦治, 表面科学学術講演会講演要旨集, 30th, 47, 04 Nov. 2010
  Japanese
• 昆虫に学ぶマテリアル・デザインの戦略
  下村政嗣; 下村政嗣; 下澤楯夫; 松尾保孝; 居城邦治; 堀繁久; 水島未記; 杉山智昭, 高分子学会予稿集(CD−ROM), 59, 2 Disk1, ROMBUNNO.1Q03, 01 Sep. 2010
  Japanese
• 非天然塩基を導入したDNAブロックコポリマーの酵素合成および塩基配列選択的な金属化
  渡辺雪江; 松尾保孝; 松尾保孝; 新倉謙一; 新倉謙一; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 59, 2 Disk1, ROMBUNNO.2X01, 01 Sep. 2010
  Japanese
• 銀微細間隙を有する銀蒸着ピラー構造化膜を用いた表面増強ラマン散乱測定
  平井悠司; 藪浩; 松尾保孝; 松尾保孝; 居城邦治; 居城邦治; 下村政嗣; 下村政嗣; 下村政嗣, 高分子学会予稿集(CD−ROM), 59, 2 Disk1, ROMBUNNO.2R13, 01 Sep. 2010
  Japanese
• ウイルスのシアル酸認識を利用した有機/無機ハイブリッドナノ粒子の構築
  永川桂大; 新倉謙一; 大竹範子; 鈴木忠樹; 松尾保孝; 澤洋文; 居城邦治, 高分子学会予稿集(CD−ROM), 59, 2 Disk1, ROMBUNNO.2PC119, 01 Sep. 2010
  Japanese
• 細胞表層修飾可能な高分子を用いたガン細胞への高効率な物質導入
  南原克行; 新倉謙一; 岡嶋孝治; 松尾保孝; 居城邦治, 高分子学会予稿集(CD−ROM), 59, 2 Disk1, ROMBUNNO.2PD116, 01 Sep. 2010
  Japanese
• 自己組織化高分子構造をマスクとして用いたシリコン微細構造の作製と濡れ性パターニング
  平井悠司; 藪浩; 松尾保孝; 松尾保孝; 居城邦治; 居城邦治; 下村政嗣; 下村政嗣; 下村政嗣, 高分子学会予稿集(CD−ROM), 59, 2 Disk1, ROMBUNNO.1Q18, 01 Sep. 2010
  Japanese
• マルトオリゴ糖界面によって特異的に促進されるナノ微粒子の核移行
  関口翔太; 新倉謙一; 吉村成弘; 松尾保孝; 居城邦治, 高分子学会予稿集(CD−ROM), 59, 2 Disk1, ROMBUNNO.1L20, 01 Sep. 2010
  Japanese
• 固体基板上でのオリゴヌクレオチド伸長反応によるホモシークエンス二重鎖DNAの合成
  江口明日美; 松尾保孝; 松尾保孝; 新倉謙一; 新倉謙一; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 59, 2 Disk1, ROMBUNNO.1PB080, 01 Sep. 2010
  Japanese
• 物質の細胞膜透過における疎水部構造の影響
  南原克行; 新倉謙一; 岡嶋孝治; 松尾保孝; 居城邦治, 高分子学会予稿集(CD−ROM), 59, 2 Disk1, ROMBUNNO.2Q09, 01 Sep. 2010
  Japanese
• フッ素化テトラエチレングリコール誘導体界面が誘起するナノ粒子自己組織化構造
  西尾崇; 松尾保孝; 松尾保孝; 新倉謙一; 新倉謙一; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 59, 2 Disk1, ROMBUNNO.2Q16, 01 Sep. 2010
  Japanese
• 多孔性無機微粒子によるゲルの高強度化
  三友秀之; 三友秀之; 富永大輝; 佐野健一; 島本直伸; 島本直伸; 居城邦治; 居城邦治; 長田義仁, 高分子学会予稿集(CD−ROM), 59, 2 Disk1, ROMBUNNO.3J06, 01 Sep. 2010
  Japanese
• 安定同位体を標識とした細胞イメージング
  YAMAMOTO KOSUKE; SAKAMOTO NAOYA; NISHIO TAKASHI; IJIRO KUNIHARU; YURIMOTO HISAYOSHI, 日本分析化学会年会講演要旨集, 59th, 168, 01 Sep. 2010
  Japanese
• 同位体顕微鏡システムおよび振動分光法によるマウス骨質の解析
  KIMURA(SUDA) HIROMI; KAJIHARA MAKOTO; SAKAMOTO NAOYA; KOBAYASHI SACHIO; IJIRO KUNIHARU; YURIMOTO HISAYOSHI; YAMATO HIDEYUKI, 高分子学会予稿集(CD-ROM), 59, 2 Disk1, ROMBUNNO.2PE123, 01 Sep. 2010
  Japanese
• 剥離層を用いた金属埋め込み半導体ピラー構造の作製
  飯島仁史; 宮村壮太; 中島秀朗; 井田惣太郎; 小田島聡; 熊野英和; 熊野英和; 西尾崇; 松尾保孝; 居城邦治; 末宗幾夫; 末宗幾夫, 応用物理学会学術講演会講演予稿集(CD−ROM), 71st, ROMBUNNO.17A-P13-12, 30 Aug. 2010
  Japanese
• 非天然塩基を導入したDNAブロックコポリマーの酵素合成と単一分子観察
  渡辺雪江; 松尾保孝; 新倉謙一; 居城邦治, 高分子学会予稿集(CD−ROM), 59, 1 Disk1, ROMBUNNO.3PD152, 11 May 2010
  Japanese
• 固体基板上に固定化したオリゴヌクレオチドの伸長反応による長鎖DNAの合成
  江口明日美; 松尾保孝; 新倉謙一; 居城邦治, 高分子学会予稿集(CD−ROM), 59, 1 Disk1, ROMBUNNO.3PC151, 11 May 2010
  Japanese
• 糖鎖修飾ナノ微粒子で明らかにする核膜孔ゲルのレクチン活性
  関口翔太; 吉村成弘; 新倉謙一; 松尾保孝; 居城邦治, 高分子学会予稿集(CD−ROM), 59, 1 Disk1, ROMBUNNO.3PB156, 11 May 2010
  Japanese
• 糖鎖修飾により促進されるナノ粒子の核移行とメカニズム解明
  新倉謙一; 松尾保孝; 居城邦治; 関口翔太; 吉村成弘, 高分子学会予稿集(CD−ROM), 59, 1 Disk1, ROMBUNNO.2G14, 11 May 2010
  Japanese
• 単電子デバイスの構築を目指したDNA‐金属ナノ粒子‐DNAの合成
  石川綾子; 鈴木健二; 鈴木健二; 松尾保孝; 新倉謙一; 居城邦治, 高分子学会予稿集(CD−ROM), 59, 1 Disk1, ROMBUNNO.1G26, 11 May 2010
  Japanese
• Strengthening of the Hydrogel with Inorganic Particles
  MITOMO Hideyuki; MITOMO Hideyuki; TOMINAGA Taiki; SANO Ken‐Ichi; IJIRO Kuniharu; IJIRO Kuniharu; OSADA Yoshihito, 高分子学会予稿集(CD−ROM), 59, 1 Disk1, ROMBUNNO.1M20, 11 May 2010
  English
• pHに応答した分子放出のためのウイルスナノカプセルの機能化
  大竹範子; 新倉謙一; 鈴木忠樹; 三國新太郎; 松尾保孝; 永川桂太; 金城政孝; 澤洋文; 居城邦治, 日本化学会講演予稿集, 90th, 3, 888, 12 Mar. 2010
  Japanese
• 非天然塩基を導入したDNAポリマーの酵素合成および塩基配列選択的な金属化
  渡辺雪江; 田中あや; 松尾保孝; 新倉謙一; 居城邦治, 日本化学会講演予稿集, 90th, 3, 785, 12 Mar. 2010
  Japanese
• 金ナノ粒子結合オリゴヌクレオチドの伸長反応による単電子デバイスの鋳型作製
  石川綾子; 松尾保孝; 鈴木健二; 鈴木健二; 新倉謙一; 居城邦治, 日本化学会講演予稿集, 90th, 3, 737, 12 Mar. 2010
  Japanese
• 固体基板上に固定化したDNAの伸長反応によるナノデバイスの鋳型作製
  江口明日美; 松尾保孝; 新倉謙一; 居城邦治, 日本化学会講演予稿集, 90th, 3, 758, 12 Mar. 2010
  Japanese
• 細胞膜におけるフッ素型脂質の高速拡散挙動の解析
  南原克行; 新倉謙一; 岡嶋孝治; 櫛田勇樹; 松尾保孝; 居城邦治, 日本化学会講演予稿集, 90th, 3, 662, 12 Mar. 2010
  Japanese
• フッ素化エチレングリコール提示ナノ粒子の作製と細胞内動態
  西尾崇; 新倉謙一; 松尾保孝; 居城邦治, 日本化学会講演予稿集, 90th, 3, 886, 12 Mar. 2010
  Japanese
• 自己組織化ハニカムマスクを用いたバイオミメティック表面を有するシリコン基板の作製
  平井悠司; 仲道裕貴; 藪浩; 松尾保孝; 松尾保孝; 居城邦治; 居城邦治; 下村政嗣; 下村政嗣; 下村政嗣, エレクトロニクス実装学会講演大会講演論文集, 24th, 206-207, 10 Mar. 2010
  Japanese
• 自己組織化を用いた超撥水・無反射シリコン微細構造体の作製
  平井悠司; 藪浩; 松尾保孝; 松尾保孝; 居城邦治; 居城邦治; 下村政嗣; 下村政嗣; 下村政嗣, 応用物理学関係連合講演会講演予稿集(CD−ROM), 57th, ROMBUNNO.18P-ZE-9, 03 Mar. 2010
  Japanese
• ナノデバイスの作製を目指した固体基板上での固定化DNAの伸長反応
  江口明日美; 松尾保孝; 新倉謙一; 居城邦治, 高分子学会北海道支部研究発表会講演要旨集, 44th, 18, 26 Jan. 2010
  Japanese
• Preparation of functionalized virus-like particles enabling pH-mediated release of target molecules
  OHTAKE Noriko; NIIKURA Kenichi; SUZUKI Tadaki; MIKUNI Shintaro; MATSUO Yasutaka; NAGAKAWA Keita; KINJO Masataka; SAWA Hirofumi; IJIRO Kuniharu, Abstr RIES Hokudai Symp, 11th, 109-110, 2010
  English
• Construction of Organic Molecular Spin Assembly Organized by Molecular Recognition between Nucleobases
  TANAKA Hiroyuki; SHIOMI Daisuke; MATSUO Yasutaka; NIIKURA Kenichi; SATO Kazunobu; TAKUI Takeji; IJIRO Kuniharu, Abstr RIES Hokudai Symp, 11th, 107-108, 2010
  English
• 同位体顕微鏡システムによる骨形成の解析
  KIMURA(SUDA) HIROMI; KAJIHARA MAKOTO; SAKAMOTO NAOYA; KOBAYASHI SACHIO; IJIRO KUNIHARU; YURIMOTO HISAYOSHI; YAMATO HIDEYUKI, 日本骨代謝学会学術集会プログラム抄録集, 28th, 163, 163, 2010
  (一社)日本骨代謝学会, Japanese
• 新規癒着防止膜としての自己組織化非対称ハニカムフィルム
  下村政嗣; 藪浩; 田中賢; 山本貞明; 伊藤絵美子; 居城邦治; 松尾保孝; 福平由佳子; 兼子博章; 平坂雅男; 山美佳; 伊藤晃寿; 白土健太郎; 山崎英数; 奥田徹彦; 東出朋巳; 杉山和久, 日本バイオマテリアル学会大会予稿集, 31st, 137, 16 Nov. 2009
  Japanese
• 新規癒着防止膜としての自己組織化ハニカムフィルム
  下村政嗣; 藪浩; 田中賢; 山本貞明; 居城邦治; 松尾保孝; 福平由佳子; 兼子博章; 平坂雅男; 山我美佳; 伊藤晃寿; 白土健太郎; 山崎英数, ポリマー材料フォーラム講演予稿集, 18th, 205, 11 Nov. 2009
  Japanese
• 電子デバイス応用に向けたDNAの塩基配列選択的な金属ナノ細線作製
  松尾保孝; 田中あや; 石川綾子; 渡辺雪江; 新倉謙一; 阿部益宏; 阿部益宏; 上村崇史; 上村崇史; 上村崇史; 松本和彦; 松本和彦; 松本和彦; 居城邦治; 居城邦治, 応用物理学会学術講演会講演予稿集, 70th, 3, 1252, 08 Sep. 2009
  Japanese
• DNA鋳型から作製した金属ナノ細線の電子デバイスへの応用
  阿部益宏; 阿部益宏; 上村崇史; 上村崇史; 上村崇史; 松本和彦; 松本和彦; 松本和彦; 石川綾子; 渡辺雪江; 新倉謙一; 松尾保孝; 居城邦治; 居城邦治, 応用物理学会学術講演会講演予稿集, 70th, 1, 225, 08 Sep. 2009
  Japanese
• オリゴ糖の高密度提示によって促進されるナノ微粒子の核内輸送
  関口翔太; 新倉謙一; 松尾保孝; 吉村成弘; 居城邦治, 高分子学会予稿集(CD−ROM), 58, 2 Disk1, ROMBUNNO.2N-08, 01 Sep. 2009
  Japanese
• ウイルスを中心とした金ナノ粒子の三次元配列構造体とその光学応答
  永川桂大; 新倉謙一; 大竹範子; 鈴木忠樹; 松尾保孝; 澤洋文; 居城邦治, 高分子学会予稿集(CD−ROM), 58, 2 Disk1, ROMBUNNO.1L5-12, 01 Sep. 2009
  Japanese
• フルオロアルキル界面を利用した半導体量子ドットの機能化検討
  西尾崇; 新倉謙一; 松尾保孝; 居城邦治, 高分子学会予稿集(CD−ROM), 58, 2 Disk1, ROMBUNNO.1PF084, 01 Sep. 2009
  Japanese
• 単電子デバイス作製を目指した金ナノ粒子結合単一DNAの酵素合成
  石川綾子; 松尾保孝; 松尾保孝; 鈴木健二; 鈴木健二; 新倉健一; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 58, 2 Disk1, ROMBUNNO.2L5-18, 01 Sep. 2009
  Japanese
• 天然・非天然塩基を用いたDNAポリマーの合成と塩基配列選択的な金属化
  渡辺雪江; 田中あや; 松尾保孝; 松尾保孝; 新倉謙一; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 58, 2 Disk1, ROMBUNNO.2Q-06, 01 Sep. 2009
  Japanese
• 細胞周期選択的に取り込まれる脂質様化合物の探索と細胞膜との相互作用
  南原克行; 新倉謙一; 神谷亮介; 岡嶋孝治; 松尾保孝; 居城邦治, 高分子学会予稿集(CD−ROM), 58, 2 Disk1, ROMBUNNO.2T2-16, 01 Sep. 2009
  Japanese
• 自己組織化ハニカム状多孔質膜を用いた無反射超撥水表面の作製
  平井悠司; 藪浩; 松尾保孝; 松尾保孝; 居城邦治; 居城邦治; 下村政嗣; 下村政嗣; 下村政嗣, コロイドおよび界面化学討論会講演要旨集, 62nd, 410, 25 Aug. 2009
  Japanese
• 分子認識を利用した水溶性量子ドットの表面修飾法の開発
  西尾崇; 新倉謙一; 松尾保孝; 居城邦治, 高分子学会予稿集(CD−ROM), 58, 1 Disk1, 1PF080, 12 May 2009
  Japanese
• ウイルスを基盤とした金ナノ粒子の三次元配列化とその光学応答
  永川桂大; 新倉謙一; 大竹範子; 鈴木忠樹; 松尾保孝; 澤洋文; 居城邦治, 高分子学会予稿集(CD−ROM), 58, 1 Disk1, 1PD088, 12 May 2009
  Japanese
• 修飾DNAの酵素合成と塩基配列選択的な金属ナノワイヤーの作製
  渡辺雪江; 田中あや; 松尾保孝; 新倉謙一; 居城邦治, 高分子学会予稿集(CD−ROM), 58, 1 Disk1, 2PE135, 12 May 2009
  Japanese
• Development of Multifunctional Envelope-Type Nano-Device (MEND) for Hepatic Gene Transfer Via i.v. Administration: Impact for the Modification with Devices for Intracellular Trafficking
  Hidetaka Akita; Tomoya Masuda; Kinichi Niikura; Takashi Nishio; Kuniharu Ijiro; Hideyoshi Harashima, MOLECULAR THERAPY, 17, S54, S54, May 2009
  English, Summary international conference
• 銀‐高分子ハイブリッドピラー構造を用いた表面増強ラマン散乱測定
  平井悠司; 藪浩; 松尾保孝; 松尾保孝; 居城邦治; 居城邦治; 下村政嗣; 下村政嗣; 下村政嗣, 応用物理学関係連合講演会講演予稿集, 56th, 3, 1319, 30 Mar. 2009
  Japanese
• 核酸塩基と金の選択的な吸着を利用したサブナノサイズ金ナノ粒子の作製
  石川綾子; 松尾保孝; 居城邦治, 日本化学会講演予稿集, 89th, 1, 178, 13 Mar. 2009
  Japanese
• ウイルス様ナノカプセルを鋳型とした金ナノ粒子の3次元配列化
  永川桂大; 新倉謙一; 大竹範子; 鈴木忠樹; 松尾保孝; 澤洋文; 居城邦治, 日本化学会講演予稿集, 89th, 2, 1256, 13 Mar. 2009
  Japanese
• オリゴ糖の高密度提示によって促進される微粒子の核移行
  関口翔太; 新倉謙一; 西尾崇; 松尾保孝; 居城邦治, 日本化学会講演予稿集, 89th, 2, 1330, 13 Mar. 2009
  Japanese
• Base Selectivity of Metal Deposition onto DNA as Template
  WATANABE YUKIE; TANAKA AYA; MATSUO YASUTAKA; IJIRO KUNIHARU, 日本化学会講演予稿集, 89th, 2, 1288, 13 Mar. 2009
  Japanese
• 塩基配列選択的な金属ナノワイヤーの作製をめざした修飾DNAの合成
  渡辺雪江; 田中あや; 松尾保孝; 新倉謙一; 居城邦治, 高分子学会北海道支部研究発表会講演要旨集, 43rd, 19, 03 Feb. 2009
  Japanese
• 糖鎖依存的な核移行における多糖化と高密度化の効果
  関口翔太; 新倉謙一; 西尾崇; 松尾保孝; 居城邦治, 高分子学会北海道支部研究発表会講演要旨集, 43rd, 29, 03 Feb. 2009
  Japanese
• LB法による水溶化CNT単分子膜の作製
  門間太志; 松尾保孝; 居城邦治, 高分子学会北海道支部研究発表会講演要旨集, 43rd, 18, 03 Feb. 2009
  Japanese
• Micro-patterned surfaces regulate cellular shape and promote proliferation of mesenchymal stem cells from rat adult bone marrow
  森田有香; 山本貞明; 山本貞明; 藪浩; 藪浩; 伊藤絵美子; 居城邦治; 居城邦治; 本望修; 下村政嗣; 下村政嗣; 下村政嗣, 日本化学会講演予稿集, 89th, 1, 2009
• ハニカムフィルムによるラット骨髄由来間葉系幹細胞の増殖促進
  山本貞明; 山本貞明; 森田有香; 藪浩; 藪浩; 伊藤絵美子; 田中賢; 田中賢; 本望修; 居城邦治; 居城邦治; 下村政嗣; 下村政嗣; 下村政嗣, 高分子学会予稿集(CD-ROM), 58, 1 Disk1, 2009
• ハニカムフィルムによる骨髄間葉系幹細胞の増殖促進
  森田有香; 山本貞明; 山本貞明; 藪浩; 藪浩; 伊藤絵美子; 本望修; 居城邦治; 居城邦治; 下村政嗣; 下村政嗣; 下村政嗣, 高分子学会予稿集(CD-ROM), 58, 2 Disk1, 2009
• 自己組織化多孔性ハニカムフィルム上の表面での間葉系幹細胞-細胞の接着形態,増殖,分化に及ぼすフィルムの材質と細孔径の影響
  森田有香; 山本貞明; 藪浩; 本望修; 居城邦治; 下村政嗣; 下村政嗣, 表面科学学術講演会講演要旨集, 29th, 2009
• 階層横断生命科学-異分野融合的研究の新展開に向けて-バイオミメティック超撥水・無反射表面の作製と表面物性の測定
  平井悠司; 藪浩; 松尾保; 居城邦治; 居城邦治; 下村政嗣; 下村政嗣; 下村政嗣, 階層横断生命科学-異分野融合的研究の新展開にむけて 理研シンポジウム 平成21年, 2009
• DNAを鋳型とした金属ナノ構造の形成制御
  居城邦治; 田中あや; 石川綾子; 新倉謙一; 松尾保孝, 高分子学会予稿集(CD−ROM), 57, 2 Disk1, 2L11, 09 Sep. 2008
  Japanese
• DNAの塩基配列に選択的なプラチナナノワイヤーの作製
  田中あや; 松尾保孝; 居城邦治, 日本化学会バイオテクノロジー部会シンポジウム講演要旨集, 11th, 374, 08 Sep. 2008
  Japanese
• ウイルスの糖鎖認識能を利用した金ナノ粒子の規則配列化
  永川桂大; 新倉謙一; 大竹範子; 鈴木忠樹; 松尾保孝; 澤洋文; 居城邦治, 日本化学会バイオテクノロジー部会シンポジウム講演要旨集, 11th, 303, 08 Sep. 2008
  Japanese
• 糖鎖提示が可能とする微粒子の核内輸送
  関口翔太; 新倉謙一; 西尾崇; 松尾保孝; 居城邦治, 日本化学会バイオテクノロジー部会シンポジウム講演要旨集, 11th, 21, 08 Sep. 2008
  Japanese
• 核酸塩基と金の選択的な吸着を利用した金ナノ粒子の分散制御
  石川綾子; 松尾保孝; 居城邦治, 応用物理学会学術講演会講演予稿集, 69th, 3, 1083, 02 Sep. 2008
  Japanese
• 単一オリゴヌクレオチド/銀ハイブリッドナノ粒子の発光特性解析
  上田哲也; 石川綾子; 石川綾子; 高島英聡; 藤原英樹; 松尾保孝; 松尾保孝; 居城邦治; 居城邦治; 笹木敬司; 竹内繁樹; 竹内繁樹, 応用物理学会学術講演会講演予稿集, 69th, 3, 1139, 02 Sep. 2008
  Japanese
• Langmuir‐Blodgett法による水溶化CNTの薄膜作製
  門間太志; 松尾保孝; 居城邦治, 応用物理学会学術講演会講演予稿集, 69th, 3, 1081, 02 Sep. 2008
  Japanese
• 光局在場を目指したウイルスカプセル表面における金ナノ粒子の規則配列化
  永川桂大; 新倉謙一; 大竹範子; 鈴木忠樹; 松尾保孝; 澤洋文; 居城邦治, 応用物理学会学術講演会講演予稿集, 69th, 3, 1218, 02 Sep. 2008
  Japanese
• 銀蒸着自己組織化ピラー構造の表面増強ラマン散乱基板への応用
  平井悠司; 藪浩; 松尾保孝; 居城邦治; 下村政嗣, 応用物理学会学術講演会講演予稿集, 69th, 3, 1092, 02 Sep. 2008
  Japanese
• DNA/銀複合ナノ粒子の作製と発光メカニズムの解明
  石川綾子; 松尾保孝; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 57, 1 Disk1, 1PG127, 08 May 2008
  Japanese
• 機能性分子の一次元配列を目指した鋳型DNAの酵素合成
  田中あや; 松尾保孝; 居城邦治, 高分子学会予稿集(CD−ROM), 57, 1 Disk1, 3H10, 08 May 2008
  Japanese
• 糖鎖量子ドットプローブを用いた細胞ストレス可視化法の開発
  西尾崇; 新倉謙一; 松尾保孝; 秋田英万; 原島秀吉; 居城邦治, 高分子学会予稿集(CD−ROM), 57, 1 Disk1, 2PE165, 08 May 2008
  Japanese
• 自己組織化高分子構造を用いた表面増強ラマン散乱測定への応用
  平井悠司; 藪浩; 松尾保孝; 居城邦治; 下村政嗣, 高分子学会予稿集(CD−ROM), 57, 1 Disk1, 3PD098, 08 May 2008
  Japanese
• 単分散DNAポリマーの酵素合成およびそれを鋳型にしたプラチナナノワイヤーの作製
  田中あや; 松尾保孝; 居城邦治, 日本化学会講演予稿集, 88th, 2, 848, 12 Mar. 2008
  Japanese
• ウイルスカプセルを鋳型とした金ナノ粒子3Dアレイの作製
  永川桂大; 新倉謙一; 大竹範子; 鈴木忠樹; 松尾保孝; 澤洋文; 居城邦治, 日本化学会講演予稿集, 88th, 2, 878, 12 Mar. 2008
  Japanese
• 超音波照射によるアゾベンゼンクロロホルム溶液の色調変化
  治田修; 松尾保孝; 居城邦治; 居城邦治, 日本化学会講演予稿集, 88th, 1, 188, 12 Mar. 2008
  Japanese
• 核酸を分散剤とした発光性銀ナノ粒子の作製とその発光特性
  石川綾子; 松尾保孝; 居城邦治, 日本化学会講演予稿集, 88th, 1, 546, 12 Mar. 2008
  Japanese
• 糖鎖提示量子ドットを用いた細胞内核内移行の解析
  関口翔太; 西尾崇; 新倉謙一; 松尾保孝; 居城邦治, 日本化学会講演予稿集, 88th, 2, 900, 12 Mar. 2008
  Japanese
• 気液界面におけるDNAの分子認識を利用したアゾベンゼン単分子膜の組織化とその光機能
  治田修; 松尾保孝; 居城邦治; 居城邦治, 日本化学会講演予稿集, 88th, 1, 468, 12 Mar. 2008
  Japanese
• ウイルスカプセルを鋳型とした金ナノ粒子3Dアレイの作製
  永川桂大; 石塚範子; 新倉謙一; 松尾保孝; 鈴木忠樹; 澤洋文; 居城邦治, 高分子学会北海道支部研究発表会講演要旨集, 42nd, 21, 29 Jan. 2008
  Japanese
• 核酸で被覆した発光性銀ナノ粒子の作製
  石川綾子; 佐藤壮人; 松尾保孝; 居城邦治; 居城邦治, 高分子学会北海道支部研究発表会講演要旨集, 42nd, 20, 29 Jan. 2008
  Japanese
• LB法によるカーボンナノチューブ薄膜作製条件の検討
  門間太志; 松尾保孝; 居城邦治, 高分子学会北海道支部研究発表会講演要旨集, 42nd, 44, 29 Jan. 2008
  Japanese
• 生体適合性ハニカム構造フィルムの作製と癒着防止材への応用
  福平由佳子; 福平由佳子; 伊東雅弥; 兼子博章; 田中賢; 藪浩; 山本貞明; 下村政嗣; 居城邦治, 高分子学会医用高分子シンポジウム講演要旨集, 37th, 2008
• 生体適合性ハニカム構造フィルムの癒着防止材への応用
  福平由佳子; 福平由佳子; 兼子博章; 藪浩; 下村政嗣; 居城邦治, ポリマー材料フォーラム講演予稿集, 17th, 2008
• 自己組織化ハニカムパターン表面での間葉系幹細胞の増殖
  森田有香; 山本貞明; 藪浩; 田中賢; 居城邦治; 下村政嗣, 表面科学学術講演会講演要旨集, 28th, 2008
• ハニカムフィルム上での多能性未分化細胞の増殖
  山本貞明; 田中賢; 森田有香; 藪浩; 居城邦治; 下村政嗣, 高分子学会予稿集(CD-ROM), 57, 2 Disk1, 2008
• ハニカムフィルム上での多能性未分化細胞の増殖
  森田有香; 山本貞明; 藪浩; 田中賢; 居城邦治; 下村政嗣, 日本バイオマテリアル学会シンポジウム予稿集, 2008, 2008
• Dynamic Cellular Stress Sensing using Sugar Displaying CdTe Quantum Dots
  NISHIO Takashi; NIIKURA Kenichi; MATSUO Yasutaka; AKITA Hidetaka; KOGURE Kentaro; HARASHIMA Hideyoshi; IJIRO Kuniharu; IJIRO Kuniharu, Abstr RIES Hokudai Symp, 9th, 110-111, 2008
  English
• Gold Nanoparticle Array using Virus Like Particles as a Scaffold
  NAGAKAWA Keita; NIIKURA Kenichi; OHTAKE Noriko; SUZUKI Tadaki; MATSUO Yasutaka; SAWA Hirohumi; IJIRO Kuniharu, Abstr RIES Hokudai Symp, 10th, 51-52, 2008
  English
• 原子間力顕微鏡によるハニカム構造フィルム上での血管内皮細胞の初期接着形態観察
  山本貞明; 水谷武臣; 田中賢; 伊藤絵美子; ENIWUMIDE J. O; 森田由香; 角南寛; 居城邦治; 川端和重; 下村政嗣, 表面科学講演大会講演要旨集, 27th, 152, 01 Nov. 2007
  Japanese
• Development of Advanced Functional Polymer/Metal Hybrid Nanomaterials
  MATSUO Yasutaka; IJIRO Kuniharu, Kobunshi, 56, 10, 845, 849, 01 Oct. 2007
  The Society of Polymer Science, Japan, Japanese
• DNAを用いた発光性銀ナノ粒子の作製とバイオイメージングへの応用
  松尾保孝; 石川綾子; 佐藤壮人; 居城邦治; 居城邦治, 生体機能関連化学シンポジウム講演要旨集, 22nd, 106-107, 10 Sep. 2007
  Japanese
• 糖鎖提示量子ドットによる細胞ストレスのイメージング技術の開発
  西尾崇; 新倉謙一; 松尾保孝; 秋田英万; 小暮健太朗; 原島秀吉; 居城邦治, 生体機能関連化学シンポジウム講演要旨集, 22nd, 344-345, 10 Sep. 2007
  Japanese
• 自己組織化により作製した銀ピラー状構造フィルム作製とそれを用いた表面増強ラマン散乱(SERS)測定
  平井悠司; 藪浩; 藪浩; 藪浩; 下村政嗣; 下村政嗣; 下村政嗣; 松尾保孝; 居城邦治, 高分子学会予稿集(CD−ROM), 56, 2 Disk1, 2V12, 04 Sep. 2007
  Japanese
• ナノギャップ電極作製のためのDNA‐x‐DNAトリブロック型ポリマーの酵素重合
  田中あや; 松尾保孝; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 56, 2 Disk1, 2X03, 04 Sep. 2007
  Japanese
• 単一細胞のストレスをイメージングできる糖鎖プローブ分子の開発
  西尾崇; 新倉謙一; 松尾保孝; 秋田英万; 小暮健太朗; 原島秀吉; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 56, 2 Disk1, 1Y17, 04 Sep. 2007
  Japanese
• 核酸塩基を用いて作製した銀ナノ粒子の発光特性
  松尾保孝; 石川綾子; 佐藤壮人; 居城邦治; 居城邦治, 応用物理学会学術講演会講演予稿集, 68th, 3, 1271, 04 Sep. 2007
  Japanese
• カーボンナノチューブ薄膜作製のための可溶化条件の検討
  門間太志; 松尾保孝; 居城邦治, 応用物理学会学術講演会講演予稿集, 68th, 3, 1229, 04 Sep. 2007
  Japanese
• オリゴヌクレオチド/銀ハイブリッドナノ粒子の作製と発光特性解析
  居城邦治; 居城邦治; 佐藤壮人; 石川綾子; 松尾保孝, 高分子学会予稿集(CD−ROM), 56, 2 Disk1, 3G01, 04 Sep. 2007
  Japanese
• 分子集合体システムの金属化による機能性ナノ構造形成
  居城邦治; 居城邦治; 田中あや; 佐藤壮人; 橋本裕一; 松尾保孝, 応用物理学会学術講演会講演予稿集, 68th, 0, 21, 04 Sep. 2007
  Japanese
• DNAでコートした銀ナノ粒子の作製と光励起発光現象
  松尾保孝; 佐藤壮人; 石川綾子; 居城邦治; 居城邦治, コロイドおよび界面化学討論会講演要旨集, 60th, 116, 03 Sep. 2007
  Japanese
• 糖鎖半導体ナノ微粒子による細胞ストレス可視化技術の開発
  新倉謙一; 西尾崇; 秋田英万; 原島秀吉; 松尾保孝; 居城邦治, バイオ・高分子シンポジウム講演要旨集, 17th, 3-4, 23 Jul. 2007
  Japanese
• DNAポリメラーゼによる塩基配列をデザインしたDNAポリマーの合成
  田中あや; 松尾保孝; 居城邦治; 居城邦治, バイオ・高分子シンポジウム講演要旨集, 17th, 65-66, 23 Jul. 2007
  Japanese
• O‐GlcNAc提示量子ドットを用いた細胞ストレス蛍光イメージング
  西尾崇; 新倉謙一; 松尾保孝; 秋田英万; 小暮健太朗; 原島秀吉; 居城邦治; 居城邦治, 日本糖質学会年会要旨集, 27th, 118, 10 Jul. 2007
  Japanese
• 細胞のストレスイメージングを可能とする糖鎖プローブの開発
  新倉謙一; 西尾崇; 松尾保孝; 秋田英万; 小暮健太朗; 原島秀吉; 居城邦治; 居城邦治, 日本糖質学会年会要旨集, 27th, 79, 10 Jul. 2007
  Japanese
• リンカー分子を介した長鎖DNAブロックコポリマーの合成
  田中あや; 松尾保孝; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 56, 1 Disk1, 1PA175, 10 May 2007
  Japanese
• 金属ナノデバイスの構築を目指したウイルスナノカプセルの作製
  永川桂大; 新倉謙一; 石塚範子; 鈴木忠樹; 松尾保孝; 澤洋文; 居城邦治, 高分子学会予稿集(CD−ROM), 56, 1 Disk1, 3PC177, 10 May 2007
  Japanese
• DNAと複合化した銀ナノ微粒子の発光挙動
  佐藤壮人; 松尾保孝; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 56, 1 Disk1, 2H29, 10 May 2007
  Japanese
• アゾベンゼンを担持した高分子薄膜におけるUV照射による蛍光増強
  治田修; 松尾保孝; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 56, 1 Disk1, 1PF116, 10 May 2007
  Japanese
• 光還元を用いた核酸塩基選択的な銀ナノ粒子の作製
  佐藤壮人; 松尾保孝; 居城邦治; 居城邦治, 応用物理学関係連合講演会講演予稿集, 54th, 3, 1292, 27 Mar. 2007
  Japanese
• アゾベンゼンからなる薄膜のUV照射による蛍光増強
  治田修; 松尾保孝; 居城邦治; 居城邦治, 日本化学会講演予稿集, 87th, 1, 286, 12 Mar. 2007
  Japanese
• 核酸で被覆した銀ナノ粒子の合成と発光観察
  佐藤壮人; 松尾保孝; 居城邦治, 日本化学会講演予稿集, 87th, 1, 233, 12 Mar. 2007
  Japanese
• O‐GlcNAc修飾量子ドットを用いた新規細胞ストレス検出法の開発
  西尾崇; 新倉謙一; 松尾保孝; 秋田英万; 小暮健太朗; 原島秀吉; 居城邦治, 日本化学会講演予稿集, 87th, 2, 1365, 12 Mar. 2007
  Japanese
• 酵素によるDNAブロックコポリマーの合成と塩基配列に選択的な修飾
  田中あや; 松尾保孝; 居城邦治, 日本化学会講演予稿集, 87th, 2, 1249, 12 Mar. 2007
  Japanese
• A special section - Selected peer-reviewed papers on soft nanotechnology
  Masatsugu Shimomura; Masatsugu Shimomura; Masatsugu Shimomura; Masatsugu Shimomura; Masatsugu Shimomura; Kuniharu Ijiro; Masanori Kikuchi; Junzo Tanaka; Junzo Tanaka, Journal of Nanoscience and Nanotechnology, 7, 01 Mar. 2007
• 超分子ナノ材料としてのウイルスカプセルの作製
  永川桂大; 石塚範子; 新倉謙一; 松尾保孝; 鈴木忠樹; 澤洋文; 居城邦治; 居城邦治, 高分子学会北海道支部研究発表会講演要旨集, 41st, 45, 06 Feb. 2007
  Japanese
• DNAブロックコポリマーの酵素合成と塩基配列選択的な金属化
  田中あや; 松尾保孝; 居城邦治; 居城邦治, 高分子学会北海道支部研究発表会講演要旨集, 41st, 8, 06 Feb. 2007
  Japanese
• O‐GlcNAc提示量子ドット特異的細胞内挙動の観察
  西尾崇; 新倉謙一; 松尾保孝; 秋田英万; 小暮健太朗; 原島秀吉; 居城邦治; 居城邦治, 高分子学会北海道支部研究発表会講演要旨集, 41st, 31, 06 Feb. 2007
  Japanese
• 血管内皮細胞の初期伸展に及ぼすハニカムフィルム細孔径の影響
  山本貞明; 山本貞明; 田中賢; 田中賢; 角南寛; 角南寛; 伊藤絵美子; 森田有香; 居城邦治; 居城邦治; 下村政嗣; 下村政嗣, 高分子学会予稿集(CD-ROM), 56, 1 Disk1, 2007
• 人工ウィルスをめざしたDNA-脂質ポリイオンコンプレックスからなる単一分子粒子の作製
  藪浩; 下村政嗣; 春菜ゆかり; 新倉謙一; 居城邦治, バイオ・高分子シンポジウム講演要旨集, 17th, 2007
• ナノバイオ大事典
  ㈱テクノシステム, 2007
• COMPREHENSIVE NANO-BIO HANDBOOK
  2007
• 糖鎖のシャペロン認識を用いた細胞ストレスセンシングの開発
  新倉謙一; 西尾崇; 松尾保孝; 秋田英万; 木暮健太朗; 原島秀吉; 居城邦治, 日本化学会バイオテクノロジー部会シンポジウム講演要旨集, 9th, 264, 19 Sep. 2006
  Japanese
• 細胞ストレスセンシングを目指した糖鎖提示量子ドットの作製
  新倉謙一; 西尾崇; 松尾保孝; 秋田英万; 小暮健太朗; 原島秀吉; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 55, 2 Disk1, 2PC121, 05 Sep. 2006
  Japanese
• オリゴヌクレオチドを保護剤とする塩基選択的銀ナノ粒子の作製
  居城邦治; 居城邦治; 松尾保孝; 佐藤壮人, 高分子学会予稿集(CD−ROM), 55, 2 Disk1, 2V02, 05 Sep. 2006
  Japanese
• DNAポリメラーゼによるブロックコポリマー型DNAの合成と単一分子観察
  田中あや; 松尾保孝; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 55, 2 Disk1, 3X09, 05 Sep. 2006
  Japanese
• 糖鎖の細胞内挙動探索を目的とした糖鎖提示量子ドットの作製
  西尾崇; 新倉謙一; 松尾保孝; 秋田英万; 木暮健太朗; 原島秀吉; 居城邦治, コロイドおよび界面化学討論会講演要旨集, 59th, 504, 30 Aug. 2006
  Japanese
• DNAポリメラーゼによって合成した長鎖DNAのLB法による伸長固定化
  田中あや; 松尾保孝; 居城邦治; 居城邦治, コロイドおよび界面化学討論会講演要旨集, 59th, 503, 30 Aug. 2006
  Japanese
• 光還元によるcore‐shell型Ag/DNAナノ粒子の作製
  佐藤壮人; 松尾保孝; 居城邦治; 居城邦治, コロイドおよび界面化学討論会講演要旨集, 59th, 9, 30 Aug. 2006
  Japanese
• DNA多重会合体形成に及ぼす5’末端リン酸基と塩の効果
  田中あや; 松尾保孝; 居城邦治, バイオ・高分子シンポジウム講演要旨集, 16th, 65-66, 01 Aug. 2006
  Japanese
• DNAポリメラーゼによる単分散DNAポリマーの合成とその単分子観察
  田中あや; 松尾保孝; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 55, 1 Disk1, 2H04, 10 May 2006
  Japanese
• 核酸を光還元剤とした金属ナノ粒子の作製
  佐藤壮人; 松尾保孝; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 55, 1 Disk1, 3PD184, 10 May 2006
  Japanese
• 糖鎖提示半導体ナノ微粒子の作製と細胞内ダイナミクス観察
  西尾崇; 新倉謙一; 松尾保孝; 秋田英万; 小暮健太朗; 原島秀吉; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 55, 1 Disk1, 3PB192, 10 May 2006
  Japanese
• LB法を用いたDNAナノパターンの形成
  松尾保孝; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 55, 1 Disk1, 3PC067, 10 May 2006
  Japanese
• Development of Nuclear Targeting System of Plasmid DNA; Impact of Sugar Display on the Surface of Lipid Envelope
  Tomoya Masuda; Hidetaka Akita; Takashi Nishio; Kenichi Niikura; Asako Kudo; Kentaro Kogure; Akitada Iwasa; Kuniharu Ijiro; Hideyoshi Harashima, MOLECULAR THERAPY, 13, S388, S388, May 2006
  English, Summary international conference
• LB法を用いたパターン化DNA薄膜の作製
  松尾保孝; 居城邦治; 居城邦治, 応用物理学関係連合講演会講演予稿集, 53rd, 3, 1290, 22 Mar. 2006
  Japanese
• DNAポリメラーゼによる単分散DNAホモポリマーの合成
  田中あや; 松尾保孝; 居城邦治, 日本化学会講演予稿集, 86th, 2, 832, 13 Mar. 2006
  Japanese
• One-pot preparation of polyion complex particles of polynucleic acid and lipids
  居城邦治; 春菜ゆかり; 樋口剛志; 藪浩; 下村政嗣, 日本化学会講演予稿集, 86th, 1, 2006
• SYNTHESIS OF DNA BLOCK COPOLYMER BY DNA POLYMERASE
  TANAKA Aya,MATSUO Yasutaka; IJIRO Kuniharu; IJIRO Kuniharu, Abstr RIES Hokudai Symp, 8th, 66-67, 2006
  English
• Syntheses of Sugar-displaying Quantum Dots as a Cellular Stress Sensing Probe
  NISHIO Takashi; NIIKURA Kenichi; MATSUO Yasutaka; AKITA Hidetaka; KOGURE Kentaro; HARASHIMA Hideyoshi; IJIRO Kuniharu; IJIRO Kuniharu, Abstr RIES Hokudai Symp, 8th, 72-73, 2006
  English
• 核酸ナノ粒子の作製
  藪浩; 居城邦治; 下村政嗣, 化学工業, 57, 11, 37, 41, 2006
  Japanese, Introduction scientific journal
• 光ピンセットを用いた神経細胞の配列制御
  門間太志; 鶴間章典; 堀田純一; 松尾保孝; 田中賢; 山本貞明; 笹木敬司; 居城邦治; 中村博; 下村政嗣, 光化学討論会講演要旨集, 2005, 416, 11 Sep. 2005
  Japanese
• 光ピンセットを用いた神経細胞の配列制御
  門間太志; 鶴間章典; 松尾保孝; 堀田純一; 田中賢; 山本貞明; 笹木敬司; 居城邦治; 中村博; 下村政嗣, 応用物理学会学術講演会講演予稿集, 66th, 3, 1128, 07 Sep. 2005
  Japanese
• LB法により誘起されるDNAナノパターンの作製
  松尾保孝; 居城邦治; 居城邦治, 応用物理学会学術講演会講演予稿集, 66th, 3, 1068, 07 Sep. 2005
  Japanese
• DNAポリメラーゼによる塩基配列をデザインした長鎖DNAの作製
  田中あや; 松尾保孝; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 54, 2 Disk1, 1W12, 05 Sep. 2005
  Japanese
• DNAネットワークパターンの無電解メッキによるメタルナノネットの作製
  佐藤壮人; 橋本裕一; 松尾保孝; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 54, 2 Disk1, 1W19, 05 Sep. 2005
  Japanese
• LB膜作製過程を利用したDNA‐高分子複合体の二次元配向制御
  松尾保孝; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 54, 2 Disk1, 2N14, 05 Sep. 2005
  Japanese
• 18)気液界面における核酸塩基の分子認識とそれを利用した色素分子の会合制御
  治田修; 橋本裕一; 松尾保孝; 居城邦治; 居城邦治, バイオ・高分子シンポジウム講演要旨集, 15th, 37-38, 01 Aug. 2005
  Japanese
• 鎖長の異なるオリゴDNAを用いた長鎖poly(dA)・poly(dT)の合成
  田中あや; 松尾保孝; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 54, 1 Disk1, 2PE165, 10 May 2005
  Japanese
• 自己組織化パターン上での神経細胞の光ピンセットを用いた配列制御
  門間太志; 鶴間章典; 松尾保孝; 堀田純一; 田中賢; 山本貞明; 笹木敬司; 居城邦治; 中村博; 下村政嗣, 高分子学会予稿集(CD−ROM), 54, 1 Disk1, 2PA179, 10 May 2005
  Japanese
• 伸長DNAを鋳型としたπ共役系発光材料の配向制御
  松尾保孝; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 54, 1 Disk1, 1PC143, 10 May 2005
  Japanese
• 感光性PVAと高分子電解質を用いた高膨張性ゲルフィルムの作製
  石塚範子; 橋本裕一; 松尾保孝; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 54, 1 Disk1, 2PA113, 10 May 2005
  Japanese
• DNAネットワークパターンを鋳型とした金属ナノネットの作製
  佐藤壮人; 橋本裕一; 松尾保孝; 居城邦治; 居城邦治, 高分子学会予稿集(CD−ROM), 54, 1 Disk1, 2G17, 10 May 2005
  Japanese
• ハニカムフィルムによる細胞外マトリックスの吸着制御
  山本貞明; 山本貞明; 角南寛; 田中賢; 田中賢; 松尾保孝; 松尾保孝; 居城邦治; 居城邦治; 山下滋京子; 森田有香; 下村政嗣; 下村政嗣, 高分子学会予稿集(CD−ROM), 54, 1 Disk1, 1G20, 10 May 2005
  Japanese
• 光ピンセットを用いた神経細胞の配列制御
  門間太志; 鶴間章典; 松尾保孝; 堀田純一; 田中賢; 山本貞明; 笹木敬司; 居城邦治; 下村政嗣, 応用物理学関係連合講演会講演予稿集, 52nd, 3, 1454, 29 Mar. 2005
  Japanese
• 5’末端がリン酸化されたオリゴDNAの多重会合体形成
  田中あや; 松尾保孝; 居城邦治, 日本化学会講演予稿集, 85th, 2, 1368, 11 Mar. 2005
  Japanese
• DNAを鋳型とした金属ナノワイヤーの作製
  橋本裕一; 松尾保孝; 居城邦治, 日本化学会講演予稿集, 85th, 1, 452, 11 Mar. 2005
  Japanese
• DNA会合体形成における末端リン酸基の効果
  田中あや; 松尾保孝; 居城邦治; 西孝行; 野堀智新; 大矢裕一; 大内辰郎, 高分子学会予稿集(CD−ROM), 53, 2 Disk1, 2PF154, 01 Sep. 2004
  Japanese
• LB法による伸長DNA分子の二次元パターン形成
  松尾保孝; 居城邦治, 高分子学会予稿集(CD−ROM), 53, 2 Disk1, 1F14, 01 Sep. 2004
  Japanese
• LB法によるDNA/高分子複合体の伸長・固定化
  松尾保孝; 居城邦治, 応用物理学会学術講演会講演予稿集, 65th, 3, 1091, 01 Sep. 2004
  Japanese
• LB法による長鎖DNAの伸長固定化
  居城邦治; 橋本裕一; 松尾保孝, コロイドおよび界面化学討論会講演要旨集, 57th, 52, 25 Aug. 2004
  Japanese
• オリゴDNA多重会合体のLB法による伸長固定化
  田中あや; 松尾保孝; 大矢裕一; 西孝行; 野堀智新; 大内辰郎; 居城邦治; 下村政嗣, 高分子学会予稿集(CD−ROM), 53, 1, IIH05, 10 May 2004
  Japanese
• LB法による伸長DNA分子の二次元配列制御
  松尾保孝; 居城邦治; 下村政嗣, 高分子学会予稿集(CD−ROM), 53, 1, IIIPC057, 10 May 2004
  Japanese
• LB法を用いたタンパク質の結合したDNA分子の伸長固定化
  松尾保孝; 居城邦治; 下村政嗣, 応用物理学関係連合講演会講演予稿集, 51st, 3, 1431, 28 Mar. 2004
  Japanese
• Two-dimensional patterns of DNA molecules prepared on the solid substrate by Langmuir-Blodgett method
  MATSUO Yasutaka; IJIRO Kuniharu, Abstr RIES Hokudai Symp, 6th, 75-76, 2004
  English
• 近接場顕微鏡を用いたDNA結合性タンパク質の単一分子検出
  居城邦治; 松尾保孝; 下村政嗣, 高分子学会予稿集, 52, 12, 3232-3233, 10 Sep. 2003
  Japanese
• LB法によるDNAのパターン形成
  松尾保孝; 居城邦治; 下村政嗣, 応用物理学会学術講演会講演予稿集, 64th, 3, 1193, 30 Aug. 2003
  Japanese
• DNAへ結合したタンパク質の単一分子イメージング
  居城邦治; 松尾保孝; 下村政嗣, バイオ・高分子シンポジウム講演要旨集, 13th, 53-54, 31 Jul. 2003
  Japanese
• LB法を用いた伸長DNA分子の配列制御
  松尾保孝; 居城邦治; 下村政嗣, 応用物理学関係連合講演会講演予稿集, 50th, 3, 1430, 27 Mar. 2003
  Japanese
• フェムト秒レーザーによる2光子吸収を利用した組織工学材料の作製
  佐藤大和; 笹谷有語; 堀之内英; 松尾保孝; 堀田純一; 田中賢; 居城邦治; 笹木敬司; 下村政嗣, 日本化学会講演予稿集, 83rd, 1, 516, 03 Mar. 2003
  Japanese
• 気水界面単分子膜を用いた単一DNA分子の配向制御・固定化 2
  松尾保孝; 三田村リカ; 居城邦治; 下村政嗣, 応用物理学会学術講演会講演予稿集, 63rd, 3, 1156, 24 Sep. 2002
  Japanese
• 単一DNA分子のLB法による二次元配向配列制御
  居城邦治; 松尾保孝; 三田村リカ; 下村政嗣, 高分子学会予稿集, 51, 10, 2399-2400, 18 Sep. 2002
  Japanese
• 環状DNAを用いた人工光合成アンテナ系構築に向けて (特集 創造科学技術の展望)
  居城 邦治; 松本 仁; 西田 仁, 化学工業, 53, 7, 501, 505, Jul. 2002
  化学工業社, Japanese
• 気水界面単分子膜を用いた単一DNA分子の配向制御・固定化
  松尾保孝; 三田村リカ; 居城邦治; 下村政嗣, 応用物理学関係連合講演会講演予稿集, 49th, 3, 1291, 27 Mar. 2002
  Japanese
• DNAミメティクスを利用した分子ナノ組織体の構築
  居城邦治; 松本仁; 下村政嗣, 高分子錯体アニュアルレビュー, 9-10, Mar. 2002
  高分子錯体研究会, Japanese, Summary national conference
• 環状DNAを利用した人工光合成アンテナ系構築に向けて
  居城邦治; 松本 仁; 西田 仁; 森末光彦; 下村政嗣, 月刊化学工業, 53, 7, 17, 21, 2002
  Japanese, Report scientific journal
• 単分子膜に配向固定化されたDNAの単一分子計測
  居城邦治; 松尾保孝; 三田村リカ; 西村紳一郎; 沢田石哲郎; 下村政嗣, 日本化学会バイオテクノロジー部会シンポジウム講演要旨集, 5th, 12, 22 Sep. 2001
  Japanese
• Template Polymerization of Diacetylene in 2-D DNA-mimetics
  MATSUMOTO Jin; IJIRO Kunikaru; SHIMOMURA Masatsugu, Photochemistry, 32, 2, 34, 39, 15 Aug. 2001
  光化学協会, Japanese
• 自己組織性を利用したDNAのインテリジェント化
  居城邦治; 松本 仁; 森末光彦; 三田村リカ; 澤田石哲郎; 下村政嗣, 高分子加工, 50, 2, 81, 87, 2001
  Japanese, Introduction scientific journal
• Construction of a 2-D pi-electron system based on specific base-pairing in the azobenzene-containing surface monolayers.
  M Morisue; K Ijiro; M Shimomura, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 218, U379, U379, Aug. 1999
  English, Summary international conference
• Formation of 2-D polydiacetylene assemblies based on DNA-mimetics at the air-water interface.
  J Matsumoto; K Ijiro; M Shimomura, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 218, U380, U380, Aug. 1999
  English, Summary international conference
• DNA複合単分子を場とした光誘起電子異動
  居城 邦治; 池田 俊明; 下村 政嗣, 電子科学研究, 7, 51, 52, 1999
  北海道大学, Japanese
• 散逸構造を利用したDNAのマイクロパターニングとその応用
  沢田石 哲郎; 下村 政嗣; 居城 邦治; Karthaus Olaf, 電子科学研究, 6, 65, 67, 1998
  北海道大学, Japanese
• PHOTO-INDUCED ELECTRON TRANSFER IN DNA MONOLAYER : Fluoresence Quenching and Photocurrent Generation in DNA Monolayer
  IKEDA Toshiaki; NAKAMURA Fumio; IJIRO Kuniharu; SHIMOMURA Masatsugu, Technical report of IEICE. OME, 97, 88, 39, 44, 09 Jun. 1997
  Owing to one-dimensionallyarrayed π-electrons, so-called "π-ways", of stacked nucleobasesalong the polymer chain, double-stranded DNA can act as a molecular wire. DNA can form polyion complexes with cationic monolayers at the air-water interface. Fluorescencequenching of octadecylacridineorange (C18AO) by an amphphilic viologene in a dialkylammonium monolayer was enhanced by complexation with DNA. The cationic monolayer containing C18AO was transferred on an ITO electrode from an aqueous polymer subphase. Photocurrentwas generated when the modified electrode of DNA or RNA monolayer was irradiated with visible light (>450nm) in aqueous solution containing EDTA as a sacrificial electron doner., The Institute of Electronics, Information and Communication Engineers, Japanese
• Design of Functional Supramolecule Based on Chitin and Chitosan
  NISHIDA Jin; NISHIMURA Shin-Ichiro; IJIRO Kuniharu; OLAF Karthous; SHIMOMURA Masatsugu, キチン・キトサン研究 = Chitin and chitosan research, 3, 2, 112, 113, 15 May 1997
  Japanese
• 遺伝子DNA内を通る長距離電子移動
  居城 邦治; 下村 政嗣, 高分子, 42, 11, 146, 147, 10 Nov. 1996
  Japanese
• センサ-テクノロジ--6-単分子膜による分子認識とオプティカルセンシング
  下村 政嗣; 居城 邦治, 蛋白質核酸酵素, 41, 1, p83, 88, Jan. 1996
  共立出版, Japanese
• 機能性高分子としての2重らせんDNAの固体素子化
  居城 邦治; 下村 政嗣, 固体物理, 30, 12, p1042, 1048, Dec. 1995
  アグネ技術センタ-, Japanese
• 核酸単分子膜による分子認識
  居城 邦治, 電子科学研究, 2, 83, 87, 1994
  研究, 北海道大学, Japanese
• 酵素-脂質複合体 (超分子化学<特集>)
  岡畑 恵雄; 居城 邦治, 化学と工業, 43, 8, p1242, 1246, Aug. 1990
  日本化学会, Japanese

• Materials Nanoarchitectonics, From Integrated Molecular Systems to Advanced Devices
  Hideyuki Mitomo; Kuniharu Ijiro, Chapter 7 Metal Nanoarchitectonics: Fabrication of Sophisticated Gold Nanostructures for Functional Plasmonic Devices
  Elsevier, Dec. 2023, [Contributor]
• バイオミメティクス・エコミメティクス ー持続可能な循環型社会へ導く技術革新のヒントー
  居城邦治, バイオミメティクス・インフォマティクスを支えるナノテクノロジー
  シーエムシー出版, Jan. 2021, [Contributor]
• Stimuli-Responsive Interfaces -Fabrication and Application-
  Hideyuki Mitomo; Kenichi Niikura; Kuniharu Ijiro, Stimuli-responsive structure control of gold nanoparticle assembly
  Springer, Nov. 2016, 127-145, [Contributor]
• 生物模倣技術と新材料・新製品開発への応用
  三友秀之; 居城邦治, 生物の持つ発色メカニズムとその応用展開
  技術情報協会, Jul. 2014, [Contributor]
• ソフトナノテクノロジーにおける材料開発
  シーエムシー出版, 2011
• 次世代バイオミメティクス研究の最前線-生物多様性に学ぶ-
  シーエムシー出版, 2011
• 現代界面コロイド科学の事典
  丸善株式会社, 2010
• 自己組織化ハンドブック
  エヌ・ティー・エス, 2009
• 超分子サイエンス＆テクノロジー－基礎からイノベーションまで－
  エヌ・ティー・エス, 2009
• 金属ナノ・マイクロ粒子の形状・構造制御技術
  シーエムシー出版, 2009
• バイオナノプロセス
  シーエムシー出版, 2008
• 量子ドットの生命科学領域への応用
  ㈱シーエムシー出版, 2007
• バイオとナノの融合Ⅱ-新生命科学の応用-
  北海道大学出版会, 2007
• 自己組織化ナノマテリアル フロンティアテクノシリーズNo.9 -フロントランナー８５人が語るナノテクノロジーの新潮流-
  フロンティア出版, 2007
• Application of Quantum Dot in Life Science
  2007
• 進化する有機半導体 有機エレクトロニクス創成へ向けた光・電子機能デバイスへの応用最前線
  エヌ・ティー・エス, 2006
• ソフトナノテクノロジー -バイオマテリアル革命-
  ソフトナノテクノロジー -バイオマテリアル革命-, 2005
• 超分子科学－ナノ材料創製に向けて－
  化学同人, 2004
• Nanotechnology toward the Organic Photonics
  Nanotechnology toward the Organic Photonics, 2002
• Studies in Surface Science and Catalysis 132
  Elsevier Science B. V., 2001

• Bio-Inspired Plasmonic Nanostructures for SERS Sensing (in person)
  Kuniharu Ijiro
  9th NaBIS, 28 Nov. 2025, English, Invited oral presentation
  28 Nov. 2025 - 28 Nov. 2025, [Invited]
• Stimuli-responsive plasmonic nanogap structure for ultrasensitive surface-enhanced Raman scattering
  Kuniharu IJIRO
  N.I.C.E. International RENDEZ-VOUS, 23 Jun. 2025, English, Keynote oral presentation
  23 Jun. 2025 - 25 Jun. 2025, [Invited]
• Biomimetic Plasmonic Nanostructures for Ultra-Sensitive Surface Enhanced Raman Scattering
  Kuniharu Ijiro
  The 1st Taiwan-Japan International Mini-Symposium, 13 Jan. 2025, English, Invited oral presentation
  13 Jan. 2025 - 14 Jan. 2025, [Invited]
• Stimuli-responsive Plasmonic Nanostructure for Surface Enhanced Raman Scattering
  Kuniharu Ijiro
  NISE 2024, 20 Nov. 2024, English, Invited oral presentation
  20 Nov. 2024 - 20 Nov. 2024
• Self-Assembly of Gold Nanoparticles in Solution
  Kuniharu Ijiro
  RIES-CEFMS Symposium, 13 Dec. 2022, English
  13 Dec. 2022 - 14 Dec. 2022, [Invited]
• Biomimetic self-assembly of nanoparticles in solutions
  Kuniharu Ijiro
  9th NaBIS, 25 Nov. 2022, English, Invited oral presentation
  25 Nov. 2022 - 25 Nov. 2022, [Invited]
• 高分子を用いた刺激応答性プラズモニック金ナノ構造体の展開
  居城邦治
  高分子学会第47回中国四国地区高分子講座, 01 Dec. 2021, Japanese, Invited oral presentation
  01 Dec. 2021 - 01 Dec. 2021, [Invited]
• Stimuli-Responsive Assemblies of Gold Nanopaericles and those applications
  Kuniharu Ijiro
  International Conference on Materials Science and Engineering (Materials Oceania 2020), 14 Oct. 2021, English, Invited oral presentation
  10 Oct. 2021 - 14 Oct. 2021, [Invited]
• Stimuli-Responsive Gold Nanoparticles Assembly and Those Applications
  Kuniharu Ijiro
  The 1st Australia-Belgium-Japan joint symposium on excitonics and cellular communication, 03 Oct. 2019, English, Invited oral presentation
  03 Oct. 2019 - 03 Oct. 2019, [Invited]
• Self-Assembly of Rod-Shaped Au Nanoparticles and those Plasmonic Functions
  Kuniharu Ijiro
  15th IUPAC International Conference on Novel Materials and their Synthesis (NMS-XV), 08 Sep. 2019, English, Keynote oral presentation
  06 Sep. 2019 - 11 Sep. 2019, [Invited]
• DNA Brush-Directed Aligning Self-Assembly of Gold Nanorods as Photonic Nanomaterials
  Kuniharu Ijiro
  16th European Conference on Organized Films (ECOF16), 10 Jul. 2019, English, Invited oral presentation
  08 Jul. 2019 - 12 Jul. 2019, [Invited]
• バイオミメティクスへの取り組みについて
  居城邦治
  機能性フィルム研究会夏季特別研修会, 05 Jul. 2019, Japanese, Invited oral presentation
  05 Jul. 2019 - 05 Jul. 2019, [Invited]
• Stimuli-Responsive Gold Nanoparticle Assembly and Those Applications
  Kuniharu Ijiro
  10th International Conference on Materials for Advanced Technologies (ICMAT 2019), 24 Jun. 2019, English, Invited oral presentation
  23 Jun. 2019 - 27 Jun. 2019, [Invited]
• Development of Stimuli-Responsive Gold Nanostructure Assembly and those Applications
  IJIRO Kuniharu
  14th IUPAC International Conference on Novel Materials and their Synthesis (NMS-XIV), 23 Oct. 2018, English, Keynote oral presentation
  [International presentation]
• ナノ粒子集積体のボトムアップファブリケーションとバイオ・フォトニクスへの応用
  居城 邦治
  日本化学会北海道支部2018年夏季研究発表会, 21 Jul. 2018, Japanese, Invited oral presentation
  [Invited], [Domestic Conference]
• 刺激応答性金ナノ構造集積体の創製と応用
  居城 邦治
  日本化学会 第98春季年会 (2018), 21 Mar. 2018, Japanese, Invited oral presentation
  [Invited], [Domestic Conference]
• DNA Brush-Directed Alignment of Extensive Gold Nanorod Arrays as Plasmonic Nanomaterials
  IJIRO Kuniharu
  The 15th Pacific Polymer Conference (PPC-15), 12 Dec. 2017, English, Invited oral presentation
  [Invited], [International presentation]
• Active gap SERS with plasmonic nanostructures on hydrogels for the sensitive detection of biomacromolecules
  IJIRO Kuniharu
  8th International Conference and Exhibition on Lasers, Optics & Photonics, 16 Nov. 2017, English, Invited oral presentation
  [Invited], [International presentation]
• Reversible pH or temperature stimulus-response self-assembly of nanoparticles
  IJIRO Kuniharu
  2017 RIES-CIS Symposium, 28 Oct. 2017, English, Invited oral presentation
  [Invited], [International presentation]
• Self-assembled Nanoparticles as Photonic and Biological Nanomaterials
  IJIRO Kuniharu
  International Symposium on Materials for Chemistry and Engineering (IMCE 2017), 03 Feb. 2017, English, Keynote oral presentation
  [Invited], [International presentation]
• DNA Brush-Directed Self-Assembly of Gold Nanorods into Vertically Aligned Arrays
  Kuniharu Ijiro; Satoshi Nakamura; Hideyuki Mitomo; Yasutaka Matsuo; Kenichi Niikura
  The 11th SPSJ International Polymer Conference (IPC 2016), 15 Dec. 2016, English, Invited oral presentation
  [Invited], [International presentation]
• Salmon DNA-based Preparation of Nanomaterials
  IJIRO Kuniharu
  The 17th Chitose International Forum on Photonics Science & Technology (CIF17), 14 Nov. 2016, English, Invited oral presentation
  [Invited], [International presentation]
• DNA Brush-Directed Vertical Alignment of Au Nanorod
  Satoshi NAKAMURA; Hideyuki MITOMO; Yasutaka MATSUO; Kenichi NIIKURA; Kuniharu IJIRO; Andrew Pike
  12th IUPAC International Confrence on Novel Materials and their Synthesis(NMS-XII), 14 Oct. 2016, English, Invited oral presentation
  [Invited], [International presentation]
• ダイナミックなナノ粒子アセンブリングによる生体分子の表面増強ラマン散乱計測
  居城 邦治
  日本分析化学会第65年会, 16 Sep. 2016, Japanese, Invited oral presentation
  [Invited], [Domestic Conference]
• バイオテンプレートを用いたナノ構造組織体の設計
  居城 邦治
  第65回高分子討論会, 14 Sep. 2016, Japanese, Invited oral presentation
  [Invited], [Domestic Conference]
• Self-assembled 2D Monolayers and 3D Vesicle of Au Nanoparticles for Photonic and Biomedical Applications
  IJIRO Kuniharu
  KJF-ICOMEP 2016, 04 Sep. 2016, English, Invited oral presentation
  [Invited], [International presentation]
• Self-assembled alignment of nanorod by using DNA brush
  Kuniharu Ijiro; Satoshi Nakamura; Hideyuki Mitomo; Andrew Pike; Yasutaka Matsuo; Kenichi Niikura
  SPIE Optics + Photonics, 29 Aug. 2016, English, Invited oral presentation
  [Invited], [International presentation]
• DNA brushes as functional interfaces for bio/nano applications
  Kuniharu Ijiro; Hideyuki Mitomo; Satoshi Nakamura; Yasunobu Suzuki; Asumi Eguchi; Yasutaka Matsuo; Kenichi Niikura
  The First International Symposium on Advanced Soft Matter, 14 Jun. 2016, English, Invited oral presentation
  [Invited], [International presentation]
• Self-Assembled Vesicles and Monolayers Prepared by Gold Nanoparticles and their SERS Applications
  IJIRO Kuniharu
  1st Student Winter WorkshopMaison France-Japan University de Strasbourg, 14 Mar. 2016, English, Invited oral presentation
  [Invited], [International presentation]
• Active Gap SERS for the Sensitive Detection of Biomacromolecules with Gold Nanoparticles on Hydrogels
  K. Ijiro; H. Mitomo; K. Horie; Y. Matsuo; K. Niikura
  JOINT WORKSHOP Frontier 2015, 01 Dec. 2015, English, Invited oral presentation
  [Invited], [International presentation]
• Self-assembly of nanoparticles: beyond the molecular scale
  IJIRO Kuniharu
  The 3rd International Symposium on AMBITIOUS LEADER’ PROGRAM Fostering Future Leaders to Open New Frontiers in Materials Science, 18 Nov. 2015, English, Invited oral presentation
  Akira Suzuki Hall, Hokkaido Univ., [Invited], [International presentation]
• Nanoparticle self-assembly for bio applications
  IJIRO Kuniharu
  2015 RIES-CIS Symposium 北海道大学電子科学研究所・台湾国立交通大学合同シンポジウム, 06 Nov. 2015, English, Invited oral presentation
  [Invited], [International presentation]
• Hydrogel-Based Active Gap Control of Gold Nanoparticle-Assembly for Surface-Enhanced Raman Scattering Measurement of Macromolecules
  IJIRO Kuniharu
  11th IUPAC International Conference on Novel Materials and their Synthesis (NMS-XI), 11 Oct. 2015, English, Invited oral presentation
  [Invited], [International presentation]
• Plasmonic nanostructures based on self-assembled nanoparticles for biosensing
  IJIRO Kuniharu
  第76回応用物理学会秋季講演会シンポジウム, 13 Sep. 2015, English, Invited oral presentation
  [Invited], [Domestic Conference]
• Gold Nanoparticle Vesicles and Those Sensing and Biological Applications Based on Plasmonic Properties
  Kuniharu Ijiro; Jinjian Wei; Yasutaka Matsuo; Hideyuki Mitomo; Kenichi Niikura
  KJF International Conference on Organic Materials for Electronics and Photonics 2015 (KJF-ICOMEP 2015), 06 Sep. 2015, English, Invited oral presentation
  [Invited], [International presentation]
• Polymer Network Based Tunable Plasmonic Device Using Nanoparticles
  IJIRO Kuniharu
  Japan-Taiwan Bilateral Polymer Symposium 2015, 02 Sep. 2015, English, Invited oral presentation
  [Invited], [International presentation]
• Nanoparticle-based biomimetic functional materials
  IJIRO Kuniharu
  SPIE Optics + Photonics 2015, 09 Aug. 2015, English, Invited oral presentation
  [Invited], [International presentation]
• ハイドロゲルを用いたチューナブルプラズモン共鳴とラマン分光への応用
  居城 邦治
  日本学術振興会「先端ナノデバイス・材料テクノロジー第151委員会」平成２６年度 第1回研究会 ハイスループット材料分科会研究会 合同研究会, 03 Jul. 2015, Japanese, Invited oral presentation
  [Invited], [Domestic Conference]
• タンパク質やナノ粒子の自己組織化によるナノカプセルの作製とそれらのバイオ・フォトニック応用
  居城 邦治
  第一回新しい原子分子組織化物質・材料創出に向けた光・量子ビーム応用技術調査専門委員会, 08 May 2015, Japanese, Invited oral presentation
  [Invited], [Domestic Conference]
• 生物の動的構造色をヒントにした表面増強ラマン散乱基板の作製
  居城 邦治
  日本化学会 第95春季年会, 26 Mar. 2015, Japanese, Invited oral presentation
  [Invited], [Domestic Conference]
• Gold nanoparticle vesicles and those unique photonic properties
  IJIRO Kuniharu
  7th french-japanese joint workshop On FRONTIER MATERIALS, 09 Dec. 2014, English, Invited oral presentation
  [Invited], [International presentation]
• 分子からナノ粒子へと展開する自己組織化
  居城 邦治
  第14回 東北大学多元物質科学研究所研究発表会, 05 Dec. 2014, Japanese, Invited oral presentation
  [Invited], [Domestic Conference]
• Fabrication of Nanoparticle Vesicles beyond Molecular Self-assembly
  IJIRO Kuniharu
  17th SNU-HU Joint Symposium Satellite "Frontiers in Chemical Sciences 2014 @ SNU & HU", 28 Nov. 2014, English, Invited oral presentation
  [Invited], [International presentation]
• The synthesis and bio/nano applications of DNA brushes
  IJIRO Kuniharu
  SPIE Optics + Photonics 2014, 17 Aug. 2014, English, Invited oral presentation
  [Invited], [International presentation]
• ゲル表面への金属ナノ構造の固定化と動的構造色への応用
  居城 邦治
  表面技術協会 2014年北海道夏期セミナー"自然に学ぶ表面処理", 01 Aug. 2014, Japanese, Invited oral presentation
  [Invited], [Domestic Conference]
• Nanoparticle Vesicles toward Biosensing and Drug Carrier
  IJIRO Kuniharu
  Synthetic Biology Meeting, 07 Jul. 2013, English, Invited oral presentation
  [Invited], [International presentation]
• Self-assembly of Nanoparticles toward Biosensing and Drug Carrier
  IJIRO Kuniharu
  1st Conference of JSPS Core to Core Program, 15 Jun. 2013, English, Invited oral presentation
  [Invited], [International presentation]
• Nanoparticle vesicles: preparation and applications in biosensing and drug delivery
  IJIRO Kuniharu
  Discussion Symposium on Artificial Life and Biomimetic Functional Materials, 29 May 2013, English, Invited oral presentation
  [Invited], [International presentation]
• Gold nanoparticle vesicles and their optical and biological applications
  IJIRO Kuniharu
  Rennes Frontier 2012 5th frence-japanese joint workshop on Frontier Materials, 02 Dec. 2012, English, Invited oral presentation
  [Invited], [International presentation]
• Self-assembly of Nanoparticles for Optical and Biological Applications
  IJIRO Kuniharu
  RIES-CIS Symposium, 25 Oct. 2012, English, Invited oral presentation
  [Invited], [International presentation]
• Room temperature coulomb blockade in a DNA-templated metal/polymeralternated hybrid nanowire
  Kuniharu Ijiro; Guoqing Wang; Hirofumi Tanaka; Liu Hong; Yasutaka Matsuo; Kenichi Niikura; Masuhiro Abe; Kazuhiko Matsumoto; Takuji Ogawa
  2012 Optics + Photonics, SPIE, 12 Aug. 2012, English, Invited oral presentation
  [International presentation]
• Fabrication of functional nanowires by DNA-mediated self-assembly
  IJIRO Kuniharu
  imec Handai International Symposium, 04 Jun. 2012, English, Invited oral presentation
  [Invited], [International presentation]
• 生体分子の分子認識を利用した機能性金属ナノ構造の自己組織化的作製
  居城 邦治
  第114回 KARCコロキウム, 05 Mar. 2012, Japanese, Invited oral presentation
  [Invited], [Domestic Conference]
• DNA-conjugated silver nanoparticles for fluorescence and Raman scattering dual-modal imaging
  IJIRO Kuniharu
  12th Chitose International Forum on Photonic Science & Technology (CIF’12), 13 Oct. 2011, English, Invited oral presentation
  [Invited], [International presentation]
• DNA-templated bottom-up fabrication of conductive nanowires
  IJIRO Kuniharu
  2011 Taiwan-Japan Bilateral Polymer Symposium (TJBPS'11), 14 Sep. 2011, English, Invited oral presentation
  [Invited], [International presentation]
• DNA-assisted fabrication of luminescent and Raman active silver nanoparticles for dual-modal bioimaging
  Kuniharu Ijiro; Guoqing Wang; Takashi Nishio; Katsuyuki Nambara; Yasutaka Matsuo; Kenichi Niikura
  SPIE Optics + Photonics 2011, 21 Aug. 2011, English, Invited oral presentation
  [Invited], [International presentation]
• DNA-Tamplated Assembly of Azobenzene at the Air-Water Interface
  Kuniharu Ijiro; Osamu Haruta; Kenichi Niikura; Yasutaka Matsuo
  PACIFICHEM 2010, 15 Dec. 2010, English, Invited oral presentation
  [Invited], [International presentation]
• 同位体顕微鏡によるバイオイメージングの可能性
  居城 邦治
  第30回 日本マグネシウム学会総会, 20 Nov. 2010, Japanese, Invited oral presentation
  [Invited], [Domestic Conference]
• Introduction of RIES‐Hokkaido University and the Study of DNA‐templated Nano Device
  Kuniharu Ijiro; Aya Tanaka; Ayako Ishikawa; Kenichi Niikura; Yasutaka Matsuo
  The 3rd Workshop on FEL Science:"Emerging X‐ray Applications in Biological Systems‐II", 04 Oct. 2010, English, Invited oral presentation
  [Invited], [International presentation]
• Synthesis of DNA-nanoparticle/DNA-nanostructure for fabrication of single-electron device
  IJIRO Kuniharu
  SPIE Optics + Photonics 2010, 01 Aug. 2010, English, Invited oral presentation
  [Invited], [International presentation]
• Base Sequence Specific Metallization of Single DNA Molecule for Application to Nano Devices
  IJIRO Kuniharu
  13th International Conference on Organized Molecular Films(LB13), 18 Jul. 2010, English, Invited oral presentation
  [Invited], [International presentation]
• Metallization of Single DNA Molecule for Application to Nano Devices
  Kuniharu Ijiro; Aya Tanaka; Ken-ichi Niikura; Yasutaka Matsuo
  2010 Japan-Taiwan Bilateral Polymer symposium (JTBPS'10), 01 Jul. 2010, English, Invited oral presentation
  [Invited], [International presentation]
• Self-assembled Hierarchic Structures of Metal-Molecule Hybrids for Sensing and Electronic Devices
  IJIRO Kuniharu
  ICEP2010, 12 May 2010, English, Invited oral presentation
  [Invited], [International presentation]
• 生体の分子認識を利用した有機-金属バイオナノシステムの構築
  居城 邦治
  ナノICTシンポジウム2010～ナノとバイオの融合が切り開く未来型ICT～, 19 Feb. 2010, Japanese, Invited oral presentation
  [Invited], [Domestic Conference]
• Fabrication of Molecular-Metal Hybrid Nanosystems based on Biomolecular Recognition
  IJIRO Kuniharu
  International Symposium on Engineering Neo-Biomimetics – Toward Paradigm Shift for Innovation –, 01 Oct. 2009, English, Invited oral presentation
  [Invited], [International presentation]
• Base Sequence-Specific Metallization of Double-Stranded DNA for Bottom-Up Fabrication Process of Nanostructure
  K. Ijiro; A. Tanaka; K. Niikura; Y. Matsuo
  International Symposium of Post-Silicon Materials and Devices Research Alliance Project, 05 Sep. 2009, English, Invited oral presentation
  [Invited], [International presentation]
• Base Sequence-Specific Metallization of DNA for Bottom-Up Process of Nanostructure Fabrication
  IJIRO Kuniharu
  HYU-RIKEN Joint Workshop & FTC One Year Anniversary Celebration, 11 Aug. 2009, English, Invited oral presentation
  [Invited], [International presentation]
• DNA-assisted fabrication of functional metal nanostructures
  Kuniharu Ijiro; Aya Tanaka; Ayako Ishikawa; Ken-ichi Niikura; Yasutaka Matsuo
  SPIE Optics + Photonics 2009, 02 Aug. 2009, English, Invited oral presentation
  [Invited], [International presentation]
• Fabrication of Nanowires by Base-Selective Metallization of DNA
  IJIRO Kuniharu
  Japan-Korea-China Mini-symposium on Nanotechnology, Biotechnology and Catalysis -Satellite Session-, 07 Nov. 2008, English, Invited oral presentation
  [Invited], [International presentation]
• DNA Sequence-Selective Fabrication of Platinum Nanowires
  IJIRO Kuniharu
  AsiaNANO2008 (Asian Conference on Nanoscience and Nanotechnology), 03 Nov. 2008, English, Invited oral presentation
  [Invited], [International presentation]
• DNA Sequence Specific Fabrication of Metal Nanostructures
  IJIRO Kuniharu
  Korea-Japan Joint Forum (KJF) 2008, 23 Oct. 2008, English, Invited oral presentation
  [Invited], [International presentation]

• ソフトマター分子科学特論, 2024年, 修士課程, 生命科学院
• ソフトマター分子科学特論, 2024年, 修士課程, 生命科学院
• 環境と人間（1単位）, 2024年, 学士課程, 全学教育
• 環境と人間（1単位）, 2024年, 学士課程, 全学教育

• American Association for the Advancement of Science
• American Chemical Society
• 高分子学会 バイオ・高分子研究会
• 高分子学会
• 電気化学会
• 応用物理学会
• 日本化学会

• 光免疫療法のための近赤外線照射で活性化する界面活性ヤヌス型ナノ粒子の創製
  科学研究費助成事業
  01 Apr. 2024 - 31 Mar. 2028
  居城 邦治
  日本学術振興会, 基盤研究(B), 北海道大学, 24K03258
• Development of Janus-shaped gold nanoparticles for cancer treatment using highly biopermeable near-infrared light
  Grants-in-Aid for Scientific Research
  30 Jun. 2022 - 31 Mar. 2024
  Ijiro Kuniharu
  In this research, we aimed to develop a photothermal therapeutic system to disrupt cancer cell membranes with gold nanoparticles (AuNPs) that absorb near-infrared (NIR) light. The AuNPs were modified with temperature-responsive ligands to express surfactant effect that destroys cell membranes via photothermal conversion. Firstly, a disc (AuND) was modified with a weakly hydrophobic ligand to provide temperature responsivity. As a result, it showed assembly/disassembly according to heating/cooling with good dispersibility. Next, a rod (AuNR) was mixed with cancer cells in a culture medium and irradiated with NIR light to demonstrate cell membrane disruption. As a result, cell viability was significantly reduced with NIR light irradiation. These results revealed that the photothermal conversion of AuNPs enables to induce the death of cancer cells with NIR light efficiently.
  Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Research (Exploratory), Hokkaido University, 22K19908
• Super-resolution live-cell imaging of cell-attached nanointerface using LSPR sheets
  Grants-in-Aid for Scientific Research
  26 Jun. 2019 - 31 Mar. 2024
  玉田 薫; 木戸秋 悟; 須川 晃資; 岡本 晃一; 居城 邦治
  課題１：超解像度超高速ライブイメージング用局在プラズモンシートの作製
  Edgeの尖った銀ナノキューブ（立方体）について単層で大面積(数mm四方)の膜を作製することに成功した。さらに水ーブタノール混合溶媒系界面での銀ナノプリズムの二次元自己組織化が、ブタノールの界面への過剰吸着とそれに起因する界面での対流に誘発されることを明らかにした。電磁場解析計算では、金属薄膜上に金属ナノ構造を配置すれば光の共鳴ピークが著しく先鋭化し、Q値が約10倍、発光増強換算で約40倍の電場増強が得られることが明らかになった。さらに集光シミュレーションを行ったところ、通常の材料の半分以下の集光スポットが得られ、高分解イメージングの可能性が示唆された。
  課題２：細胞接着ナノ界面の創製と分子ダイナミクスの直接観察
  細胞接着の初期段階において、これまでに報告されていない新たな繊維状新生接着体の形成を発見した。この構造体は細胞が基板に接触した直後にのみ放射状に現れ、細胞が成熟した接着斑を形成し伸展を始めると消失する。またこの構造体はフィブロネクチン処理基板など細胞接着性表面では現れず、細胞が接着しにくい基板でのみ細胞の剥離を抑えるように現れる。これは局在プラズモンシートによる高解像度・高速イメージングによって初めて可視化されたもので、これについて論文発表し、プレス発表をした。さらに今後課題３で実施する医療応用（幹細胞/がん細胞の動態診断）の試験観察を始め、細胞腫によって界面での深さ方向の動き（ダイナミクス）に違いがあることを見出した。
  その他、国際共同研究の成果として、台湾師範大学との共同研究において、ペロブスカイト量子ドットを使った発光メモリーデバイスの開発に成功し、その成果についてNature Comm.に発表した。台湾国内では20社を超える新聞発表/TV報道がなされ、日本へもYahooニュースとして逆輸入され注目を集めた。
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (S), Kyushu University, 19H05627
• Dynamics of biomimetic hierarchical structure
  Grants-in-Aid for Scientific Research
  28 Jun. 2012 - 31 Mar. 2017
  Hosoda Naoe
  The hierarchy of the sub cellular size structure of the creature develops various functions such as self-healing (surface of the leaves), the reversible adhesion (attachment device of the insect), self-alignment and antifouling (the surface of a slug and the lotus leaves). This study finds out about the mechanism of each function from the point of view of biophysics, the materials science or surface science and aimed at the innovative materials development.
  We achieved successfully a development of the superior multilayer films coating which conventional artificial materials did not have self-healing, antifouling, and development of the self-alignment which used the bubble by an idea new at all, the realization of a reversible adhesive mechanism approximately as scheduled.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), National Institute for Materials Science, 24120005
• Innovative Materials Engineering Based on Biological Diversity
  Grants-in-Aid for Scientific Research
  28 Jun. 2012 - 31 Mar. 2017
  SHIMOMURA MASATSUGU
  Biomimetics is the innovative paradigm shift based on biodiversity. Biodiversity is not only the result of evolutionary adaptation but also the optimized solution of “an epic combinatorial chemistry” for sustainability. Biomimetics is an emergent interdisciplinary field of natural history, biology, ecology, mathematics, physics, chemistry, nanotechnology, materials science, mechanical engineering, architecture, economics, and sociology. The comprehensive “translational research” combining various fields of science and technology is indispensable to open the new paradigm based on ”biological diversity” and “human wisdom”. Through the design and fabrication of materials and devices based on knowledge obtained from biological diversity and a biological process, we aim to make a platform for development of new industry by compiling a "Biomimetics database".
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), 24120001
• Fabrication of meta-material by programmable plating of DNA
  Grants-in-Aid for Scientific Research
  2010 - 2012
  IJIRO Kuniharu
  Top-down processes, such as photolithography, have been approaching a limit with regard to the fabrication of fine structures. For the preparation of molecular-scale fine structures, it is important that conventional self-assembly methods should be adapted to a “programmable self-assembly” as a next-generation bottom-up system. We aim to fabricate nano-gap electrodes by sequence-selective metallization of template DNA. We have already reported the fabrication of sequence-selective platinum nano-wires using poly(guanine) and poly(adenine-thymine) diblock DNA, which is enzymatically polymerized as a template. That method, however, cannot be extended to the preparation of oligoblock DNA. In this study, we prepared triblock DNA sequences using guanine as a platinum-binding natural nucleotide and 7-deaza-guanine as a platinum-nonbinding unnatural nucleotide for the construction of platinum nano-wires with nano-gap structures.
  Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 22655059
• Fabrication of DNA conjugated gold nanoparticle for single electron devices
  Grants-in-Aid for Scientific Research
  2010 - 2012
  IJIRO Kuniharu; SANO Kenichi; NIIKURA Kenichi; MATSUO Yasutaka; SHIMAMOTO Naonobu; MITOMO Hideyuki
  DNA-based nanoparticle assembly is powerful tool for fabrication of nanostructures such as nano-patterning, whereas it is required to prepare nanoparticles in which a discrete and known number of single-stranded oligonucleotides are attached by thiol. We attempted to polymerize single primer-template DNA bound to Au nanoparticles by DNA polymerase, Klenow Fragment exo- (KF-), depending on reaction time. The AFM observation and gel electrophoresis suggest that KF- extended the short primer template bound to Au nanoparticle.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 22350076
• New approach for the detection of cellular stresses based on chaperone-carbohydrate interactions
  Grants-in-Aid for Scientific Research
  2007 - 2009
  NIIKURA Kenichi; IJIRO Kuniharu; KOGURE Kentaro
  For quantitative detection of stress responses to cells, we have developed sugar-displaying CdTe as a stress sensing probe in cells. During three years (H19-H21), we obtained following two results;
  1. GlcNAc-QDs were accumulated in cells when stimulating the cells by adding heavy metals as chemical stresses.
  2. The coating of QDs with α-Glucose can efficiently promote the nuclear import of QDs. This fact leads to various medical applications, such as drug delivery systems (DDSs) and bioimaging.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 19350078
• ウイルスを鋳型とした金属微粒子3次元規則配列構造の構築
  科学研究費助成事業
  2007 - 2008
  新倉 謙一; 澤 洋文; 松尾 保孝; 居城 邦治
  ウイルスのタンパク質が自己集合して形成するウイルス様微粒子(virus-like particle : VLP)は、ウイルスゲノムを持たずにウイルスと同じ経路で細胞内へ導入されるため、ドラッグデリバリーシステムのキャリアー等として注目されている。私たちはVLPの持つ糖鎖認識性に着目し、糖鎖の分子認識を利用してウイルスの周辺に規則的に金属微粒子を配列させることを目的に研究を進めた。まず金微粒子にシアル酸を提示させる技術を確立した。このシアル酸提示金微粒子は非常に水への分散性が高く、ウイルスと結合させても沈殿するようなことはなかった。VLPとシアル酸を修飾した金ナノ粒子の複合体形成の電子顕微鏡像(STEM)を詳細に検討すると、VLPの表層に特異的に金ナノ粒子が結合している様子が観察された。また、紫外可視吸収スペクトルの長波長シフトには、金ナノ粒子表面のシアル酸の有無によって有意な差が生じたことから、溶液中でも金ナノ粒子がVLPに結合していることが示された。さらに金ナノ粒子濃度の上昇に伴いプラズモン吸収の長波長側への大きなシフトが測定された。これはウイルスを鋳型とした金ナノ粒子の結合により、三次元的なプラズモンのカップリングが起きたことを意味している。さらにウイルスと金微粒子の結合を促進するために、デキストランを添加した。この効果は高分子クラウディング効果と言われるが、金属微粒子と生体分子(この場合はVLP)の特異的な結合をクラウディング効果で成功させた初めての例である。本研究によってウイルス-金微粒子複合体が外部の光と共鳴するプラズモン共鳴体になりうることを証明できた。
  日本学術振興会, 萌芽研究, 北海道大学, 19655058
• Preparation of Single Molecular Electronics Device based on DNA-Conductive Polymer Conjugate
  Grants-in-Aid for Scientific Research
  2007 - 2008
  IJIRO Kuniharu; NIIKURA Kkenichi; MATSUO Yasutaka
  高度情報通信社会を将来にわたって持続的に発展させるためには、電子デバイスの微細化と高性能化を低コストでさらに進めなければならないが、これは従来の半導体デバイスの延長線上では実現が困難であり、それに代わる新しいナノデバイスの開発が不可欠である。そこで本研究では単一分子で動作する極微細ナノデバイスの作製を目標として、DNAの自己組織化と無電解メッキを応用することで単一分子デバイスを作製する手法の開発を行った。
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 19350106
• Rapid Prototyping of Novel Optical Materials by using Self-organized Rapid Prototyping of Novel Optical Materials by using Self-organized Honeycomb-Patterned Polymer Films
  Grants-in-Aid for Scientific Research
  2006 - 2008
  SHIMOMURA Masathugu; IJIRO Kunihara; MATSUO Yasutaka; YABU Hiroshi
  本研究では、ボトムアップナノテクノロジ-のキ-技術である自己組織化によるナノ・ミクロ構造形成と、成熟した技術である無電解メッキを組み合わせることで、全湿式プロセスによるラピッドプロトタイピングが可能であることを示すことができた。また、マイクロメ-タ-スケ-ルの細孔を有するハニカム様多孔質フィルムが赤外領域でフォトニック結晶になりうることを確認しており、細孔径のサブミクロン化によって可視光領域でのフォトニック結晶が可能となる。金属化により、高屈折率化と力学強度にすぐれた材料が期待される。
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), 18201019
• メニスカスにおけるDNAの伸長ダイナミクスの解明
  科学研究費助成事業
  2005 - 2006
  居城 邦治; 新倉 謙一; 松尾 保孝
  これまで申請者は、DNA水溶液上にカチオン性の両親媒性化合物を展開し、静電的相互作用により気水界面に形成したDNA分子とのポリイオン複合膜をLangmuir-Blodgett(LB)法により、単分子膜に流動性を持たせた状態で固体基板上に移し取ると、溶液中ではランダムコイル形状であったDNA分子が伸長して固定化されることを見い出してきた。伸長・固定化された個々DNAA分子は長さ解析の結果、単一分子であることが明らかとなり、また二重らせんDNA鎖をほぼ伸び切り構造で2次元に配列することができることを示した。しかし、DNAが伸長するメカニズムは明らかになっていない。そこで研究では、これまで未開拓であったメニスカスにおける高分子鎖のダイナミクスの計測技術の開発を通じて、LB法によるDNAの伸長機構を明らかにすることを目的とした。
  DNAが気体・液体・固体の三相が交差するメニスカスにおいて伸長されることから、メニスカスでのDNA分子の運動を観察できる蛍光顕微鏡システムを構築した。このシステムを用いてDNA水溶液上にジアルキルアンモニウム塩(2C_<18>N^+2C_1)を展開することで気液界面に形成した2C_<18>N^+2C_1/DNAポリイオン複合単分子膜の観察を行った。その結果、糸まり状のDNAがメニスカス境界部分で数秒間滞留し、その後基板状に伸長した状態で固定化されていく様子が観察された。一方、溶液中のDNAはメニスカス部分で対流を行うだけで固定化されないことが分かった。一度固定化した伸長DNAを90度回転させて引き上げを行ったところ、部分的に強固な接着点が存在することが解明された。
  また、山形大学・佐野研究室との班内共同研究によって、Langmuir-Blodgett(LB)法により、DNA分子の伸長固定化を利用することで、これまで伸長・配向化が困難とされてきたカーボンナノチューブの伸長固定化を行った。DNAとカーボンナノチューブを水溶液中で混合し、DNAが巻き付いたカーボンナノチューブ複合体を作製し、これをLB法により固体基板上に伸長・固定化できることがわかった。
  日本学術振興会, 特定領域研究, 北海道大学, 17034003
• 自己組織化ハニカム構造体を用いた電界放出素子の開発
  科学研究費助成事業
  2004 - 2005
  下村 政嗣; 居城 邦治; 田中 賢; 藪 浩
  本研究の課題は、水滴を鋳型として自己組織的に形成されるハニカム状多孔質膜の上面を粘着テープ等で剥離することで、突起状の構造体を形成し、これをメッキすることにより、電界放出素子への応用を検討することにある。
  期間中にハニカム状多孔質膜の上面を剥離した後無電解メッキを行うことにより、銀等の金属からなるピラー状構造体が形成できることを見いだした。さらに無電会メッキの手法を応用することで、酸化亜鉛等の金属酸化物半導体をメッキできることを見いだした。これらの成果により特許を1報出願した。
  さらに、単なる金薄膜あるいは作製した金属ナノピラー構造と、金をスパッタリングしたITO基板とを、100〜200μm程度のギャップを空けて設置し、減圧した後、その間に1〜100Vの電圧を引加した時に、どの程度電流が流れるかを、微小電流・抵抗測定器によって測定したところ、薄膜の場合よりもピラー構造の場合の方が、約3倍程度電流が流れることを見いだした。この成果により、特許を1報出願した。
  以上の結果より、本研究課題の目標であった、自己組織化によるピラー構造の形成と、その金属化により、電界放出素子の作製の基本動作確認が出来た。
  日本学術振興会, 萌芽研究, 北海道大学, 16651074
• Fabrication of Hierarchic DNA Nano-Array based on Stretched DNA
  Grants-in-Aid for Scientific Research
  2004 - 2005
  IJIRO Kuniharu; SHIMOMURA Masatsugu; TANAKA Masaru; NIIKURA Kenichi; MATSUO Yasutaka; YABU Hiroshi
  The DNA micro-array method is very important fundamental technique. For high-through put analysis, the high density and high degree of integration of a DNA array is required. However, the DNA spots density less than 20 mm cannot be achieved by using conventional photolithography and spotter. Therefore we attempted to develop DNA arrangement technology with 100 nm distance by the FISH (Fluorescence In-situ Hybridization) method based on a stretched single DNA molecule as a template for the DNA array.
  We demonstrated that oligonucleotides whose sequences were 40mer and overlapped by 20mer were formed multi-assemblies. The structural change from a linear to a circle was dependent on metal cations. This result suggested that we could design DNA structures by adding cations. In order to control the DNA structures, we investigated the concentration of cations to induce structural changes and sequences to interact with cations specifically. Four sorts of oligonucleotides, which contained A-tract or not, or A-tract position was different, were prepared. Each of the multi-assemblies provided different electrophoretic gel patterns in TE, TE containing Na^+ or Mg^<2+>. It concluded that metal ion changed the structure of DNA multi-assemblies from linear to circular forms.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), HOKKAIDO UNIVERSITY, 16310079
• 新規に分子設計した生体適合性高分子の合成とバイオメディカルインターフェイスの構築
  科学研究費助成事業
  2003 - 2004
  田中 賢; 下村 政嗣; 居城 邦治
  Poly(2-methoxyethyl acrylate)(PMEA)表面は、細胞に対する活性化が軽微であり、表面に吸着したタンパク質の構造変化が小さいことを明らかにした。PMEA中の水の構造を調べたところ、-100℃からの昇温過程で水のコールドクリスタリゼーション(CC)に由来する発熱ピークが-40℃付近に観測された。一方、生体適合性の劣る高分子ではこのような水の存在は認められなかった。CCとして観測される中間水量が生体適合性に強く影響を及ぼしていることを見いだした。この中間水は、高分子表面の自由水と不凍水との界面に存在し、また、高い分子運動性を有するPMEA鎖に弱く束縛され、低温下でも分子運動性の高い水であることを明らかにした。また、PMEAと同様の中間水を有する生体適合性高分子:poly(tetrahydrofurfuryl acrylate)(PTHFA)、poly[2-(2-ethoxyethoxy)ethyl acrylate](PEEA)を新規合成した。PEEAおよびその類似体は下限臨界共溶温度を有することがわかった。さらに、高分子溶液を高湿度下でキャストするだけで、孔径の均一な多孔質薄膜が様々な生体適合性材料で作製できることを利用して、その多孔質薄膜の3次元構造制御に成功した。体内埋め込み型治療器具表面にもこの膜を作製することができた。多孔質薄膜表面に粘着テープを張って剥離することによって、剥離破断面(テープ側と基板側)にナノピラー構造を作製した。ナノピラー構造の前駆体となる多孔質薄膜の材質、孔径、膜厚や剥離方法を変えることで、突起の長さや太さ、間隔の制御が可能であった。これらの表面で神経系・消化器系・血管系細胞を培養したところ、正常細胞の増殖性や機能を上昇させることに成功した。一方、がん細胞の増殖性・細胞死を制御できることを見いだした。
  日本学術振興会, 萌芽研究, 北海道大学, 15650083
• Development of planner polymer devices by using self-organization based on non-equilibrium phenomena
  Grants-in-Aid for Scientific Research
  2002 - 2004
  SHIMOMURA Masatsugu; IJIRO Kuniharu; TANAKA Masaru; YAMAMOTO Sadaaki; MATSUO Yasutaka; YABU Hiroshi
  We have studied the fabrication of planner polymer devices by using self-organization based on non-equilibrium phenomena. Honeycomb-patterned films from various kinds of functional polymers were prepared by casting polymer solutions under humid conditions. Water droplets were condensed onto the solution surface by evaporation cooling, and finally, the micro-porous polymer films were formed after complete evaporation of solvent and template water droplets. Polymer nano-particles were prepared by mixing a poor solvent into a polymer solution, and following evaporation of a good solvent, By using this method, various kinds of polymers including biodegradable, electron conductive, and electro-luminescence polymers were prepared. The particle size was controlled from tens nm to tens micrometer by changing the preparation condition (e.g. concentration of polymer solution, ratio between the poor solvent and polymer solution). Furthermore, we fabricated the hybrid structures of the honeycomb-patterned micro-porous film and functional nanoparticles by casting the water dispersion of nanoparticles onto the UV-Ozone treated honeycomb-patterned films. UV Ozone treatment change the surface properties of the honeycomb-patterned films from hydrophobic to hydrophilic. The polymer nanoparticles were embedded onto the pores of hoenycomb structures by capillary force.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), HOKKAIDO UNIVERSITY, 14205132
• Characterization of Oriented Thin Films of DNA
  Grants-in-Aid for Scientific Research
  2001 - 2004
  OKAHATA Yoshio; MORI Toshiaki; KAWASAKI Takayashi; FURUSAWA Hiroyuki; IJIRO Kuniharu; KINJO Masataka
  Deoxyribonucleic acids (DNAs) are important as a source of biological information depending on their base sequences. DNA is also interesting as a molecular material that shows a long rod-like duplex structure with base-pair stacking-the base separation is 3.4 Å while the diameter of the duplex is about 20 Å, therefore appears to be a good candidate for one-dimensional energy transfer and conduction along the p electron clouds of the stacked bases.
  In this report, we summarize preparations of DNA-aligned Langmuir-Blodgett (LB) film and its anisotropic electron conductivity.
  The DNA aligned film was prepared as follows. On the aqueous solution of DNA from Salmon testes and intercalator (ethidium bromide), Langmuir monolayer of cationic lipids were prepared, and DNA-lipid complexes were transferred on a substrate. It was confirmed by polarized absorption spectra that DNA strands aligned along a dipping direction.
  The dc conductivity was measured by using an ammeter in atmosphere. When the DNA film was put on the comb-shaped electrode as DNA strands aligned perpendicularly to two Au electrodes, a large ohmic current was observed that increased linearly with increasing the applied voltage up to 0.1 V. On the contrary, when the film was put as DNA strands aligned parallelly to two electrodes, electric current was hardly observed even at the voltage of 0.1 v.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research on Priority Areas, Tokyo Institute of Technology, 13132205
• Fabrication of nano-devices of self-assembled semiconductor nano-particles based on DNA template
  Grants-in-Aid for Scientific Research
  2002 - 2003
  IJIRO Kuniharu; TANAKA Masaru; SHIMOMURA Masatsugu
  We have studied the fabrication of nano metal wires by the electroless plating of stretched DNA immobilized on a substrate as a template. A cationic amphiphile (dimethyldihexadecylammonium, 2C_<16>N2C_1) monolayer was spread on a Lambda DNA-Tris buffer solution mixed with fluorescence probe. YOYO-1 and excess platinum compounds (ex.cis-diamminedichloroplatinum). After the formation of a polyion complex monolayer at the air-water interface, dimethylammine borane was added to the subphase to reduce the platinum compound for catalyzing the electroless deposition of silver metal. The monolayer was compressed at 5mN/m and transferred on a glass substrate by the vertical lifting method It was confirmed that DNA was stretched and aligned along the dipping direction on the substrate by fluorescence microscopy. The substrate was immersed in a silver electroless plating solution to deposit silver metal on the substrate. AEM observation after the metallization procedure showed that thin lines (ca.50mm height and 50〜100mm width) were fabricated on the substrate. Electrical current mapping obtained by conductive AFM indicated that electric current was observed on the obtained line structure.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), HOKKAIDO UNIVERSITY, 14350480
• Micro-fabrication of Tissue Engineering Scaffolds by photon and self-organization
  Grants-in-Aid for Scientific Research
  2001 - 2003
  TANAKA Masaru; SASAKI Keiji; IJIRO Kuniharu; SHIMOMURA Masatsugu; MATUSHITA Michiaki; TOUDOU Satoru
  The possibility to replace damaged or diseased organs with artificial tissues engineered from a combination of living cells and biocompatible patterned-scaffolds is becoming a reality through multidisciplinary efforts^1. Compared with light or electron beam lithography and bottom-up technologies using the self organization^2, the virtue of two-photon polymerization^3 as a tool for making microdevices lies in its three dimensional capability, which has found application in photonic devices and micromachines with feature sizes close to diffraction limit. The present studies describe the preparation of biocompatible patterned surfaces by two photon polymerization. Newly synthesized poly(2-methoxyethyl acrylate)^4 copolymers, which have biocompatibility and potocrosslinking moiety, as well as photo-initiators:trans-4-(P-(N-ethyl-N hydroxylethylamino)styryl)-N-methylpyridium-tetraphenyl borate, is transparent to an ultrashort-pulsed beam from a Ti:sapphire mode-locked laser (750-800nm, 8OMHz, 100fs) and allows it to penetrate deeply. The polymer can be poto-polymerized by using two-photon adsorption. After the pattern is completed, unreacted polymer is washed away with an metylethylketone. The fabrication parameters affecting the spatial resolution are investigated. The resolution can be controlled in the range from sub-μm to 5-μm by changing the laser-pulse energy (laser power), exposure time, polymer type, excitation wavelength, and scanning speeds. The biocompatible micro-patterned surfaces could be used for various medical devices, eg, implants, biosensor chip and cell-supported scaffolds.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 13558102
• 環状DNAを用いた人工光合成系の構築
  2000 - 2003
  居城 邦治
  植物や細菌などの光合成では、光エネルギーがアンテナ複合体と呼ばれるタンパク質内で環状に並んだ色素分子に捕捉された後に、化学エネルギーへと変換されています。本研究では、(デオキシ)リボ核酸の持つ特異的な構造を利用して、色素分子が環状に並んだ人工アンテナ分子をつくることで、クリーンなエネルギー変換システムを可能とする人工光合成系の構築を目指します。
  科学技術振興機構, 戦略的な研究開発の推進/戦略的創造研究推進事業/さきがけ, 7700000563
• 塩基対形成で組織化したジアセチレンアレーによる単一分子ワイヤーの作製と導電性測定
  科学研究費助成事業
  2001 - 2002
  居城 邦治
  カーボンナノチューブやシクロデキストリンチューブやミセルの集合体などに見られるチューブ構造は、ナノメートルスケールで物質の輸送することができることから、大変注目されている。しかし、チューブ構造は長さがマイクロメートルに至るため、分子設計して全体を合成することは大変困難である。そこで環状構造体を積み重ねればチューブ構造が形成できると考えた。これまで我々は気水界面における核酸塩基対形成について研究を行ってきた。核酸塩基対の形成は相補的すなわち特異的であり、また方向性が制限されていることから、環状構造体の積み重ねの駆動力として使えると考えた。すなわち環状のオリゴヌクレオチドを用いることで塩基対形成によりチューブ構造が形成できると期待される。本申請の研究目的は、環状オリゴヌクレオチドを合成し、水溶液中や有機溶媒中において自己組織化によりチューブ構造を作製することである。交付期間内に環状オリゴヌクレオチドの合成法の確立とチューブ構造の作製条件を探索する。
  上記の目的に従って、本年度は下記のことを行った。
  1 環状オリゴヌクレオチドの合成
  液相法で環状オリゴヌクレオチドを合成した。リン酸基を保護したままヌクレオチドを伸張し、環化反応を行い、その後リン酸基の保護基をはずして目的物を得た。今年度は環状オリゴチミン4量体、環状オリゴチミン6量体、環状オリゴチミン8量体、環状オリゴチミン10量体を合成した。
  2 環状オリゴヌクレオチドの分子認識
  合成した環状オリゴヌクレオチドを含む下水相表面に、アデニン界面活性剤の単分子膜を作製し、環状オリゴチミンの塩基対形成について検討したところ、ワトソン-クリック型の塩基対が形成することがわかった。
  日本学術振興会, 萌芽研究, 北海道大学, 13875179
• Development of DNA Detection Method using Photo-induced Electron Transfer
  Grants-in-Aid for Scientific Research
  2000 - 2001
  IJIRO Kuniharu; TANAKA Masaru; SHIMOMURA Masatsugu
  Double-stranded DNA is expected to show function as a molecular wire based on the π-electron array structure, so-called "π-ways", of stacked nucleic acid bases. DNA-mediated photo-induced electron transfer between electron donors and acceptors which are intercalated or bound to base pairs in polynucleotides has been investigated. We have reported that the amphiphilic intercalator, C_<18>AO^+, monolayer can be intercalated into DNA and other polynucleotides at the air-water interface and the composite monolayer with ordered DNA array can be transferred on the solid support.
  Here we report, DNA-mediated photo-induced electron transfer in the monolayers containing electron donor and acceptor at the air-water interface. Binary mixed monolayers (an amphiphilic donor, C18AO+ and cationic amphiphile, 2C18N+2C1) and ternary mixture (an amphiphilic acceptor C12BphC5V2+) were prepared on the aqueous subphases of double-stranded DNA, RNA and other anionic polymers.
  Pressure-area isotherms and fluorescence spectra were measured simultaneously at the air-water interface by Langmuir film balance equipping fluorescence microscope. Electron transfer quenching of C18AO+ fluorescence by C12BphC5V2+ molecule are clearly. Fluorescence quenching was enhanced by DNA and RNA, but not affected by synthetic anionic polymers. This phenomenon is observed only in the double-stranded DNA and RNA. Therefore hybridization of single-stranded DNA and RNA with complementary DNA and RNA can be detected by the photo-induced electron transfer through DNA and RNA combined with the ternary monolayer.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), HOKKAIDO UNIVERSITY, 12555225
• Preparation of one-dimensional pi-electron system based on DNA-mimetics
  Grants-in-Aid for Scientific Research
  1999 - 2001
  SHIMOMURA Masatsugu; TANAKA Masaru; IJIRO Kuniharu
  DNA and DNA-mimetics are chosen for preparation of one-dimensional pi-electron systems with controlled nanostructure (chromophore arrangement, number of chromophores, chromophore orientation, etc.) because of their specific molecular recognition, controlled base sequence and molecular wight. Two types of Langmuir monolayers complexed with DNA molecules at the air-water interface were prepared for single DNA stretching and template polymerization of the DNA-mimetics, respectively. Single DNA molecule can be stretched on the solid surface when the ionic complex of a double-stranded DNA and a cationic monolayer was transferred slowly from water surface to the hydrophilic solid surface by using conventional Langmuir-Blodgett technique. The surface monolayer of the diacetylene containing nucleobase amphiphiles parepared as DNA-mimetics can form complementary hydrogen bonds with single stranded DNAs at the air-water interface. The single-stranded DNA molecule can act as a template of photopolymerization of the diacetylene groups in the DNA-mimetics. Combination of two methods will provide a new preparation strategy of single molecular devices having one-dimensional pi-electron system.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research on Priority Areas (B), HOKKAIDO UNIVERSITY, 11223202
• 分子性機能材料・単一分子デバイスとしてDNAの新展開
  科学研究費助成事業
  2000 - 2000
  下村 政嗣; 岡畑 恵雄; 西 則雄; 居城 邦治; 田畑 仁; 大野 弘幸
  本調査は、核酸ならびに関連物質を分子性機能材料として新しく展開しようとしている生体機能関連化学、高分子化学、応用物理学、ならびに光化学の研究者と、単一分子検出を専門としている分光学、生物物理、物理光学の研究者が、核酸高分子の材料化の手法、構造評価、機能化について情報を交換し、DNAを分子情報と分子フォトニクスの機能をあわせもつ単一分子素子としての新しい展開の可能性を探るものである。核酸高分子を材料化しようとする試みは、分子組織化の技術と分子レベルでの構造観察技術の著しい展開を背景に、ここ数年、世界的に注目されはじめている。核酸高分子を機能性高分子としてとらえ、分子レベルで設計された分子性機能材料として展開するためには、LB法や自己組織化法などを用いて分子自身の組織化力を有効に利用して分子配列や配向制御を可能とする分子組織化技術や、レーザー光放射圧や原子間力などを用いた分子操作技術、などの発展が強く要求される。また、これらの技法を用いて作製した分子デバイスの分子レベルにおける構造評価には、走査型プローブ顕微などによる形態観察や分子間力などの物理パラメーターの測定、単一分子の分光学的測定が不可欠になる。このように、核酸高分子の分子レベルの組織化と構造評価法の開発は、学際的な共同研究によるアプローチを前提とした本調査によってはじめて可能となる。核酸の有する機能の最も特徴的なものは、きわめて選択性の高い塩基間での水素結合、インターカレーションと呼ばれる核酸塩基対間への物質の特異的な取り込み現象、などに基づく分子認識能である。本調査では、化学力顕微鏡による塩基配列の直接的な読みとり、インターカレーションを用いた塩基選択的な光化学反応など、分子認識機能に関する調査・検討を行った。また、最近、DNA中でスタックした塩基対を介した長距離電子移動の可能性が示され、注目を集めるとともに盛んな議論がなされている。本調査では、DNAならびにその類似物における高速な光物理化学現象と分子フォトニクス材料への展開を、光化学、単一分子分光学、などの立場から検討した。
  日本学術振興会, 基盤研究(C), 北海道大学, 12895026
• 近接場プローブ顕微鏡を用いた単一DNA分子のセンシング
  科学研究費助成事業
  1999 - 2000
  居城 邦治
  本研究の目的は、DNA分子1個のゲノムマッピングを、近接場プローブ顕微鏡を用いた蛍光観察で行うことにある。そのためには、蛍光標識された特異的オリゴヌクレオチドがハイブリッドした単一DNA分子を基板上に引き伸ばして固定化する新手法の開発、また超高感度での蛍光観察のための近接場プローブ顕微鏡へのフォトンカウンティング技術の応用が必要不可欠である。昨年度は、固体基板に引き伸ばして固定化されたDNA1分子に結合した蛍光標識プローブを調べるために、新たにフォトンカウンティングを装備した超高感度近接場プローブ顕微鏡を用いて、引き伸ばされたDNA1分子の蛍光像とDNA自身のトポグラフ像(表面の凹凸)を同時に測定した。本年度はこの手法を用いて単一DNA分子に結合した単一蛍光分子の蛍光像の測定を試みた。具体的には
  1)気水界面にて脂質-DNA複合体の単分子膜を形成させ、これをガラス基板に垂直引き上げ法により移し取りDNA試料を作製した。超高感度近接場プローブ顕微鏡により単一DNA分子の長さとDNAの分子量との関係を調べ、DNA一分子が完全に引き延ばされる条件を調べた。(居城邦治ら,高分子加工,50,33(2001))
  2)無蛍光標識二重らせんDNAを引き伸ばしてガラス基板に固定化し、FISH法を行い超高感度近接場プローブ顕微鏡で蛍光プローブの空間的位置を一分子レベルすなわちナノメーターレベルでの計測を試みた。しかし、現有のフォトカウンティングシステムでも単一蛍光分子からの蛍光信号を検出することは困難であった。今後は近接場プローブ顕微鏡の光検出部をより高感度なAPDに交換して引き続き実験を行う予定である。
  日本学術振興会, 奨励研究(A), 北海道大学, 11750682
• Hierarchical Mesoscopic Structures of Polymer Complexes
  Grants-in-Aid for Scientific Research
  1998 - 1999
  SHIMOMURA Masatsugu; NISHIKAWA Takehiro; KARTHAUS Olaf; IJIRO Kuniharu
  This study is cooperative research between physicists of the surface analysis and polymer chemists of thin film preparation. The purpose of this study is hierarchical structuring of the two-dimensional polymer complexes from nanometer to micrometer scale by using self-assembling and self-organization of molecules and molecular assemblies. Self-assembled monolayers of nucleobase amphiphile were preapered on gold surface. The formation of the complementary base pairing at the monolayer interface was observed by surface plasmon resonance technique. A honeycomb patterned film having bio-compatibility was prepared by the simple casting method. The two-dimensional topography of the patterned polymer thin film was observed as contrast image of the plasmon resonance microscope.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)., HOKKAIDO UNIVERSITY, 10044051
• 原子間力顕微鏡を用いた単一DNAの二次元導電性測定
  科学研究費助成事業
  1997 - 1998
  居城 邦治
  本研究の目的は、DNA分子の二次元導電性を測定することである。そのためには、DNA1分子を伸ばして固体基板に固定化する技術、さらに微少領域の二次元導電性を測定できる装置の開発、を行う必要がある。今年度は、1)単分子膜を鋳型とした伸び切り鎖DNAの基板への固定化、2)伸び切り鎖DNAの導電性AFM測定、について研究を行った。
  1) 単分子膜を鋳型とした伸び切り鎖DNAの固定化
  昨年度は、DNAとカチオン性両親媒性化合物である2C_<18>N+2C_1からなるポリイオンコンプレックスのクロロホルム溶液を、劈開した雲母基板上にキャストすることで、DNA数分子が伸ばされ束になったナノ細線を作製することができた。しかし、このときDNA鎖は両親媒性化合物で覆われているために、新たに開発した導電性AFMでは光導電性を測定することができなかった。そこで裸のDNA分子を固定化するために新たに単分子膜を鋳型とした方法を開発した。DNA水溶液上に2C_<18>N+2C_1を展開して単分子膜を作製した。2Cs_<18>N+2C_1はカチオン性なのでアニオン性のDNAと気水界面で静電的に吸着する。下水相のDNA濃度を希薄にして、単分子膜をガラス基たに垂直浸漬法で移し取ると、伸びたDNA分子が二次元に孤立した状態で固定化されることが、蛍光プローブを用いた蛍光顕微鏡観察でわかった。移し取るときの単分子膜とガラス表面との間の水が流動するときにDNA分子が配向・延伸したものと考えられる。
  4) 伸び切り鎖DNAの導電性AFM測定
  今回開発した手法によって作製した伸び切り鎖DNA分子の光導電性を、昨年度に開発した導電性AFMを用いて測定した。しかし、DNA分子に沿った光導電性を映像化することができなかった。おそらくDNAに流れる電流量が小さすぎるためと考えられる。現在、導電性AFMの電流測定の感度を上げることを試みている。
  日本学術振興会, 奨励研究(A), 北海道大学, 09750862
• Immobilization of DNA for Single Molecule Detection
  Grants-in-Aid for Scientific Research
  1997 - 1998
  SHIMOMURA Masatsugu; NISHIKAWA Takehiro; KARTHAUS Olaf; IJIRO Kuniharu
  Double-helical DNA is a supramolecular architecture composed of complementary base-pairings of adenine-thymine and cytosine-guanine based on specific hydrogen bonding, and carries genetic information. Due to the stacking interaction of p-electrons at the ground states of the base-pairs, DNA can act as a p-electron medium for the photoinduced electron transfer. Toward the single molecule detection of DNA by using a novel optical technique based on the combination of near field optics and photoinduced electron transfer, polynucleic acids have been immobilized as two-dimensional molecular assemblies or single molecule by means of the specific intermolecular interaction at the air-water interface. DNA, having phosphate groups in its backbone, was assembled with counter charged amphiphiles and fixed as a polyion complex monolayer at the air-water interface. We have investigated the effect of DNA on the fluorescence lifetime of a binary component monolayer of an acridine amphiphile and a cationic double chain amphiphile. Strong fluorescence quenching was found when polyG polyC was dissolved in a water subphase. Static quenching of acridine fluorescence, probably due to the electron transfer from guanine base, is occurred because the fluorescence life-time is not so reduced as fluorescence intensity. The photoinduced electron transfer to an ITO electrode was measured by an electrochemical method. Anodic photosensitized current of the amphiphilic acridine dye is enhanced by the complex formation with polynucleic acids. PolyG polyC, whose guanine base is assumed to be *idized by the excited state of the acridine moiety, is most effective for photocurrent generation. By using the simple casting method we have prepared mesoscopic stripe pattern of DNA on a mica substrate. An aqueous DNA solution mixed with/without an aqueous alginic acid solution was dropped onto a fleshly cleaved mica surface and dried by heating up to ca. 80ﾟC.The mesoscopic lines parallel to the receding direction of the solvent were observed in the cast film. When alginic acid were added in the aqueous DNA solution, more regularly aligned stripe patterns were obtained. Height of those lines was below 10 nm.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Hokkaido University, 09304070
• DNAで分子エレクトロニクス素子をつくる
  1994 - 1997
  居城 邦治
  巨大分子である二重鎖DNAの単分子膜を気液界面に形成させることにより、高い秩序構造を持った場を創り出し、電荷移動錯体等を配向、配列させて、特異な光機能を有する超分子システムの構築を目指します。
  科学技術振興機構, 戦略的な研究開発の推進/戦略的創造研究推進事業/さきがけ, 7700000279
• DNA微量分析のための走査型化学力顕微鏡の開発
  科学研究費助成事業
  1996 - 1996
  居城 邦治
  本研究では、DNAの1分子内の塩基配列を調べるために、AFMのプローブ(探針)の先端を塩基対と結合するよう化学修飾して、特異的な水素結合を調べられるような走査型化学力顕微鏡(SCM)を開発することを目的とした。ここでは走査型化学力顕微鏡(SCM)の動作確認を単純化した系で行った。基板表面およびAFMのプローブ表面が親水的もしくは疎水的の場合、プローブに動く力がどうなるのかをフォースカーブにより調べ、そのマッピングを試みた。
  1.AFMのプローブをアルカンチオールで修飾するために、プローブ表面をクロム次いで金を蒸着装置にて被覆した。電子顕微鏡観察により10個に2個の割合でプローブ先端まで被覆されることがわかった。
  2.金で被覆されたプローブをアルカンチオール溶液に浸し自己組織膜を形成させ、プローブ表面を疎水化した。
  3.親水的な基板として劈開した雲母を用い、疎水的な基板としてポリスチレンキャストフィルムを用いた。裸の金表面を持つプローブでは親水性、疎水性基板ではフォースカーブに差はなかった。それに対して疎水化処理したプローブでは異なるフォースカーブを得られた。すなわち、疎水化プローブと疎水表面とは吸着力(化学力)は弱いのに対して、親水表面では強いことがわかった。
  4.ポリスチレン微粒子(疎水性)が雲母基板上(親水性)で点在する試料を作製した。これを疎水化プローブで、256×256点で1ポイントごとにフォースカーブを測定し、トポグラフィーおよび吸着力のマッピングに成功した。ポリスチレン微粒子はトポ像では山のように見えるものの、吸着力が雲母表面に比べ弱いことから吸着力のマッピングでは低く見えた。
  以上の結果より、プローブと基板表面間の特異的な化学力(吸着力)を測定することで、相補的な水素結合による化学種の検出、すなわちDNAの塩基配列の読み出しが可能であるとが示された。
  日本学術振興会, 奨励研究(A), 北海道大学, 08750936
• 水晶発振子と高感度蛍光顕微鏡を組み合わせた単分子DNA電気泳動法の研究
  科学研究費助成事業
  1995 - 1995
  居城 邦治
  本研究では、DNAの分子量を測定する方法として、新たに水晶発振子と高感度蛍光顕微鏡を組み合わせたDNA1分子の電気泳動の超微量直接観察法を開発することを目的とした。今年度の実験では、高感度蛍光顕微鏡によるDNAの超微量直接観察法の確立と水晶発振子への電気泳動用電極の加工法の検討を行った。
  1.カチオン性界面に固定化されたDNA分子の電気泳動を確認するために、ガラスを基板とした、くし形電極上に、カチオン性脂質ジオクタデシルジメチルアンモニウムブロマイドの気水界面単分子膜1層をラングミュアー-ブロジェット法により累積した。
  2.1kbpから100kbpのDNAフラグメントの希薄水溶液から、修飾くし形電極上に静電相互作用によりDNAを固定化した。
  3.固定化しDNA孤立分子を、蛍光色素YOYOで染色して、画像処理装置を組み合わせた高感度蛍光顕微鏡で観察した。さらに原子間力顕微鏡による観察も行った。
  4.くし形電極に数ボルトから数十ボルトの静電圧を印可して、DNA分子の陽極への移動を観察した。水溶液の塩強度およびpHを種々変化させてもDNA分子の移動は観察されなかった。おそらく、単分子膜表面の4級アンモニウムとDNAのリン酸の結合が強すぎるためと考察される。そのためDNAの界面への結合を弱くする、例えば、単分子膜に非イオン性脂質を添加してカチオン密度を下げる、もしくは4級アンモニウム塩脂質の代わりに1級アミン脂質を使用する、ことが改善策として期待される。
  5.水晶発振子上に、電気泳動用電極を金のスパッタリング法により作製を試みた。しかし、このために入手した水晶発振子基板の直径が、1.5cmと小さかったために電気泳動用電極の作製は困難であった。スパッタリング法による電極作製には直径は3cm以上必要であることがわかった。
  日本学術振興会, 奨励研究(A), 北海道大学, 07855112
• 核酸-脂質複合体への蛍光色素取り込みを利用した相補的塩基対形成の高感度検出
  科学研究費助成事業
  1994 - 1994
  居城 邦治
  本研究の目的は、水面上にジアルキル型脂質と長鎖アルキル基を持つ一本鎖DNAからなる核酸-脂質複合体を作製すること、および、水相に添加した相補的なDNAとの塩基対形成を、二重鎖DNAに特異的にインターカレートされる色素からの蛍光発光を利用することで高感度に検出しようとすることにある。
  1.核酸-脂質複合体として、一本鎖DNAの最小単位の一つである塩基シトシンに長鎖アルキル基を導入したオクタデシルシトシンを新規に合成した。
  2.水面上でのインターカレーションを観察するために、色素インターカレーターであるアクリジンオレンジに長鎖アルキル基を導入したオクタデシルアクリジンオレンジを新規に合成した。
  3.アデノシン、シチジン、ウリジン、グアノシンをそれぞれ添加した水相上にオクタデシルシトシンの単分子膜を作製して、表面圧-面積曲線を測定した結果、水相にグアノシンが存在するときのみ安定な単分子膜の形成が確認できたことから、水面上での核酸-脂質複合体のシトシンと水相中のグアノシンとの塩基対形成が示唆された。
  4.核酸-脂質複合体にオクタデシルアクリジンオレンジを混合させ、水面上での蛍光顕微鏡観察を行ったところ、グアノシン水溶液上では緑色発光が認められ、水面上で形成された塩基対間へのアクリジンオレンジのインターカレーションが確認された。
  以上の結果より、インターカレーションによる蛍光発光を利用した水面上での塩基対形成の検出は可能であることがわかった。
  日本学術振興会, 奨励研究(A), 北海道大学, 06854039
• 脂質分子膜被覆酵素の有機溶媒中での触媒作用とその薄膜化
  科学研究費助成事業
  1991 - 1992
  岡畑 恵雄; 居城 邦治
  研究目的 本研究の目的は、酵素の表面を脂質膜で被覆することにより酵素機能を改変し、有機溶媒中での不斉エステル合成触媒として利用したり、薄膜化酵素を作ることにある。
  研究成果の概要 1)エステラーゼやプロテアーゼなどの酵素水溶液と糖親水基をもつ合成ジアルキル脂質の水分散液を混合して、析出した白色の沈澱を集めて凍結乾燥して酵素ー脂質複合体を得た。
  2)得られた酵素ー脂質複合体をイソオクタンなどの有機溶媒に溶かし、これに種々のカルボン酸と不斉アルコールあるいは不斉アミンを加えて室温度で不斉選択エステル化、アミド化反応を行なった。反応は設備備品として初年度に購入したインキュベーターを用いて行なった。その結果、脂質修飾リパーゼは1ーPhenylethanolのRー体を不斉選択的にエステル化することがわかった。
  3)酵素の由来や有機溶媒の種類、基質の化学構造を系統的に変化させたところ、酵素の由来により基質選択性や有機溶媒中での安定性が大きく異なることがわかった。すなわち、酵素の由来や用いる有機溶媒の極性を変化させることにより、基質選択性や不斉選択性が制御できることがわかった。
  4)酵素としてオキシゲナーゼやヒドロゲナーゼを用いて酵素ー脂質複合体を作製し、有機溶媒に溶かして水面上に展開し、LangmuirーBlodgett(LB)法を用いて白金電極上に1-2層累積した。水溶液中に基質を加えたときの選択的酸化還元反応を電気量から追跡したところ、酸化還元反応の応答性が高いことがわかった。
  日本学術振興会, 一般研究(B), 東京工業大学, 03453116

• PARTICLE AGGREGATE, MANUFACTURING METHOD FOR PARTICLE AGGREGATE, FLUORESCENCE ENHANCING ELEMENT, AND DEVICE USING PHOTOCHEMICAL REACTIONS
  Patent right, NATIONAL UNIVERSITY; CORPORATION; HOKKAIDO UNIVERSITY; IJIRO KUNIHARU; NIIKURA KENICHI; IYO NAOKI; NISHIO TAKASHI
  特願2012JP054279, 22 Feb. 2012
  特開WO 2012/115151
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  Patent right, IJIRO Kuniharu
  特願PCT/JP2006/320806, 19 Oct. 2006
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  Patent right, IJIRO Kuniharu
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