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Nishimoto Naoki
| Hokkaido University Hospital Institute of Health Science Innovation for Medical Care | Specially Appointed Associate Professor |
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■ Papers- 北海道における多系統萎縮症レジストリ研究 HoRC-MSA2014-2025
松島 理明; 工藤 彰彦; 佐久嶋 研; 金谷 泰宏; 西本 尚樹; 澤田 潤; 松岡 健; 上杉 春雄; 南 尚哉; 佐光 一也; 武井 麻子; 久原 真; 玉腰 暁子; 佐藤 典宏; 矢部 一郎
臨床神経学, 65, 11, 847, 847, (一社)日本神経学会, Nov. 2025
Japanese - Trends in Invasive Interventions and Risk Factors for Early Critical Events in Multiple System Atrophy.
Monami Tarisawa; Masaaki Matsushima; Akihiko Kudo; Taichi Nomura; Hisashi Uwatoko; Shinichi Shirai; Ikuko Takahashi-Iwata; Ken Sakushima; Hiroaki Yaguchi; Isao Yokota; Naoki Nishimoto; Jun Sawada; Takeshi Matsuoka; Haruo Uesugi; Naoya Minami; Kazuya Sako; Asako Takei; Shin Hisahara; Yasuhiro Kanatani; Akiko Tamakoshi; Norihiro Sato; Ichiro Yabe
Cerebellum (London, England), 24, 5, 152, 152, 06 Sep. 2025, [International Magazine]
English, Scientific journal, Multiple system atrophy (MSA) is a progressive, adult-onset neurodegenerative disorder involving autonomic failure, cerebellar ataxia, and parkinsonism. Patients often require invasive interventions, such as gastrostomy or tracheostomy, and sudden death is common. This study aimed to elucidate patterns of invasive treatment and identify risk factors for tracheostomy or sudden death within 5 years of onset. In total, 214 patients diagnosed with MSA between November 2014 and October 2024 across 66 institutions in Hokkaido were enrolled in the Hokkaido Rare Disease Consortium for MSA (HoRC-MSA). Patients were grouped by clinical course and interventions. We analyzed use of invasive procedures, including enteral nutrition via gastrostomy, enterostomy, esophagostomy, nasogastric tube insertion, central venous nutrition, tracheostomy, and ventilator support. Multivariable analyses were performed to compare patients with and without early critical events, defined as tracheostomy or sudden death within 5 years of disease onset. Invasive procedures were performed in 63.1% of patients. Patients receiving enteral nutrition and tracheostomy had prolonged survival. Early events correlated with older onset age (mean, 65.9 years), orthostatic hypotension, stridor, and an elevated apnea-hypopnea index (median, 32.45). Patients with preserved activities of daily living (ADL) in the Unified MSA Rating Scale part Ⅳ also had an increased risk of early critical events. Autonomic dysfunction, sleep-disordered breathing, and vocal cord impairment predict key risk factors for early mortality in patients with MSA. Monitoring is necessary, regardless of preserved ADL. The impact of invasive interventions on quality of life should be further explored. - Low HDL cholesterol levels in women and hypertriglyceridemia in men: predictors of MASLD onset in individuals without steatosis.
Tsubasa Tsutsumi; Takumi Kawaguchi; Hideki Fujii; Yoshihiro Kamada; Yuichiro Suzuki; Koji Sawada; Miwa Tatsuta; Tatsuji Maeshiro; Hiroshi Tobita; Takemi Akahane; Chitomi Hasebe; Miwa Kawanaka; Takaomi Kessoku; Yuichiro Eguchi; Hayashi Syokita; Atsushi Nakajima; Tomoari Kamada; Hitoshi Yoshiji; Hiroshi Sakugawa; Asahiro Morishita; Tsutomu Masaki; Takumi Ohmura; Toshio Watanabe; Yoshioki Yoda; Nobuyuki Enomoto; Masafumi Ono; Kanako Fuyama; Kazufumi Okada; Naoki Nishimoto; Yoichi M Ito; Hirokazu Takahashi; Michael R Charlton; Mary E Rinella; Yoshio Sumida
Journal of gastroenterology, 60, 7, 891, 904, Jul. 2025, [Domestic magazines]
English, Scientific journal, BACKGROUND: Individuals with metabolic-associated steatotic liver disease (MASLD) have a worse prognosis compared to patients without steatosis, and its prevalence is increasing. However, detailed risk factors based on obesity and sex remain unclear. We aimed to investigate the impact of cardiometabolic risk factors (CMRFs) on the risk of MASLD in individuals without pre-existing SLD. METHODS: SLD was diagnosed by ultrasonography. Non-SLD individuals were followed 65,657 person-years. Incidence rates of MASLD were assessed by Kaplan-Meier analysis. Furthermore, independent factors associated with the development of MASLD were identified using Cox regression analysis, stratified by four groups: obese men, non-obese men, obese women, and non-obese women. RESULTS: The overall incidence rate of MASLD was 39.3/1,000 person-years. The cumulative incidence was highest in obese men, followed by obese women, non-obese men, and non-obese women. Two or more CMRFs increased the risk of MASLD in all groups. Low HDL cholesterol level was the strongest independent risk factor in both obese and non-obese women and hypertriglyceridemia for both obese and non-obese men. The impact of these CMRFs was stronger in non-obese individuals. (HR [95% CI]: women non-obese 1.9 [1.5-2.4], obese 1.4 [1.1-1.8]; men non-obese 2.3 [1.9-2.9], obese 1.5 [1.2-2.0]). CONCLUSIONS: Multiple CMRFs are important to MASLD development, regardless of sex and obesity. In this Japanese cohort, low HDL cholesterol in women and hypertriglyceridemia in men were the most significant risk factors, especially among the non-obese group. These findings suggest that sex-specific CMRFs may play a role in the development of MASLD. - Alcohol Intake and Cardiometabolic Risk Factors Are Independently Associated With a Higher AST/Platelet Ratio Index in Obese Males
Hideki Fujii; Yoshihiro Kamada; Yuichiro Suzuki; Koji Sawada; Miwa Tatsuta; Tatsuji Maeshiro; Hiroshi Tobita; Tsubasa Tsutsumi; Takemi Akahane; Chitomi Hasebe; Miwa Kawanaka; Takaomi Kessoku; Yuichiro Eguchi; Hayashi Syokita; Atsushi Nakajima; Tomoari Kamada; Hitoshi Yoshiji; Takumi Kawaguchi; Hiroshi Sakugawa; Asahiro Morishita; Tsutomu Masaki; Takumi Ohmura; Toshio Watanabe; Yoshioki Yoda; Nobuyuki Enomoto; Masafumi Ono; Kanako Fuyama; Kazufumi Okada; Naoki Nishimoto; Yoichi M. Ito; Hirokazu Takahashi; Yoshio Sumida; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG‐NAFLD)
Liver International Communications, Mar. 2025, [Peer-reviewed]
English, Scientific journal, - 北海道における多系統萎縮症レジストリ研究 HoRC-MSA2014-2024
松島 理明; 足澤 萌奈美; 工藤 彰彦; 佐久嶋 研; 金谷 泰宏; 西本 尚樹; 澤田 潤; 松岡 健; 上杉 春雄; 南 尚哉; 佐光 一也; 武井 麻子; 久原 真; 玉腰 暁子; 佐藤 典宏; 矢部 一郎
臨床神経学, 64, 11, 841, 841, (一社)日本神経学会, Nov. 2024
Japanese - 北海道における多系統萎縮症レジストリ研究 HoRC-MSA2014-2024
松島 理明; 足澤 萌奈美; 工藤 彰彦; 佐久嶋 研; 金谷 泰宏; 西本 尚樹; 澤田 潤; 松岡 健; 上杉 春雄; 南 尚哉; 佐光 一也; 武井 麻子; 久原 真; 玉腰 暁子; 佐藤 典宏; 矢部 一郎
臨床神経学, 64, 11, 841, 841, (一社)日本神経学会, Nov. 2024
Japanese - The Movement Disorder Society Criteria: Its Clinical Usefulness in Multiple System Atrophy.
Monami Tarisawa; Masaaki Matsushima; Akihiko Kudo; Ken Sakushima; Yasuhiro Kanatani; Naoki Nishimoto; Jun Sawada; Takeshi Matsuoka; Shin Hisahara; Haruo Uesugi; Naoya Minami; Kazuya Sako; Asako Takei; Akiko Tamakoshi; Norihiro Sato; Hidenao Sasaki; Ichiro Yabe
Internal medicine (Tokyo, Japan), 18 Mar. 2024, [Domestic magazines]
English, Scientific journal, Objective In 2022, Wenning et al. proposed the Movement Disorder Society Criteria (MDS Criteria) for the Diagnosis of Multiple System Atrophy (MSA). These criteria were expected to provide useful alternatives to the second consensus statement. We examined trends in these diagnostic criteria. Methods We used patient data registered with the Hokkaido Rare Disease Consortium for Multiple System Atrophy, which has been recruiting patients with MSA through medical facilities in Hokkaido since November 2014. Patients were evaluated according to the MDS criteria based on neurological examinations and imaging findings at three separate times: the first evaluation, the time of enrollment (diagnosis), and the most recent evaluation (final evaluation). Results The MDS criteria were examined in 68 of 244 patients enrolled between November 2014 and July 2022. At the initial evaluation, the classifications were as follows: clinically established (n=27; 39.7%); clinically probable (n=13; 19.1%); possible prodromal (n=12; 17.6%); and negative (did not meet criteria (n=16; 23.5%). At the time of diagnosis, the classifications were as follows: clinically established (n=45; 66.2%); clinically probable (n=12; 17.6%); possible prodromal (n=4; 5.9%); and negative (n=7; 10.3%). At the final evaluation, the classifications were as follows: clinically established (n=52; 76.5%); clinically probable (n=9; 13.2%); possible prodromal (n=2; 2.9%); and negative (n=5; 7.4%). Conclusions We were able to clarify the changes in the criteria values and transition of patients due to the clarification of imaging and supportive findings in the MDS criteria. - 北海道における多系統萎縮症レジストリ研究 HoRC-MSA2014-2023
松島 理明; 足澤 萌奈美; 工藤 彰彦; 佐久嶋 研; 金谷 泰宏; 西本 尚樹; 澤田 潤; 松岡 健; 上杉 春雄; 南 尚哉; 佐光 一也; 武井 麻子; 久原 真; 玉腰 暁子; 佐藤 典宏; 佐々木 秀直; 矢部 一郎
臨床神経学, 63, 11, 780, 780, (一社)日本神経学会, Nov. 2023
Japanese - 多系統萎縮症新診断基準の有用性の検討
市之川 萌奈美; 松島 理明; 工藤 彰彦; 佐久嶋 研; 西本 尚樹; 澤田 潤; 松岡 健; 南 尚哉; 佐光 一也; 武井 麻子; 久原 真; 佐藤 典宏; 佐々木 秀直; 矢部 一郎
臨床神経学, 63, Suppl., S249, S249, (一社)日本神経学会, Sep. 2023
Japanese - Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2014 to 2018 in Japan: A large-scale multicenter retrospective study.
Hideki Fujii; Yuichiro Suzuki; Koji Sawada; Miwa Tatsuta; Tatsuji Maeshiro; Hiroshi Tobita; Tsubasa Tsutsumi; Takemi Akahane; Chitomi Hasebe; Miwa Kawanaka; Takaomi Kessoku; Yuichiro Eguchi; Hayashi Syokita; Atsushi Nakajima; Tomoari Kamada; Hitoshi Yoshiji; Takumi Kawaguchi; Hiroshi Sakugawa; Asahiro Morishita; Tsutomu Masaki; Takumi Ohmura; Toshio Watanabe; Norifumi Kawada; Yoshioki Yoda; Nobuyuki Enomoto; Masafumi Ono; Kanako Fuyama; Kazufumi Okada; Naoki Nishimoto; Yoichi M Ito; Yoshihiro Kamada; Hirokazu Takahashi; Yoshio Sumida; Japan Study Group Of Nonalcoholic Fatty Liver Disease Jsg-Nafld
Hepatology research : the official journal of the Japan Society of Hepatology, 03 Aug. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, AIM: The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. The aim of this study was to determine the recent prevalence and clinical characteristics of NAFLD in Japan. METHODS: This study initially included 410,061 retrospectively enrolled adults from the medical health checkup registry for metabolic syndrome, chronic kidney disease, and fatty liver in Japan (MIRACLE-J; UMIN-CTR no. UMIN000049419), who were evaluated between 2014 and 2018 at 13 health centers in Japan. Subjects consuming > 20 g of alcohol/day or with chronic liver disease were excluded. Fatty liver was diagnosed by ultrasonography. The probability of NAFLD with advanced fibrosis was estimated based on the fibrosis-4 index (FIB-4) and NAFLD fibrosis score (NFS). RESULTS: A total of 71,254 subjects were included in the final analysis. The overall prevalence of NAFLD was 25.8%. There was a significant, 2-fold difference in NAFLD prevalence between males (37.4%) and females (18.1%). NAFLD prevalence increased linearly with body mass index, triglycerides, and low-density lipoprotein cholesterol regardless of threshold values, even in the absence of obesity. Among patients with NAFLD, 14% had diabetes mellitus, 31% had hypertension, and 48% had dyslipidemia. The estimated prevalence of NAFLD with advanced fibrosis was 1.7% and 1.0% according to FIB-4 and NFS, respectively. CONCLUSIONS: The prevalence of NAFLD was approximately one-quarter of the general population in Japan. There was a linear relationship between NAFLD prevalence and various metabolic parameters, even in nonobese subjects. The prevalence of NAFLD with advanced fibrosis was estimated to be 1% to 2%. This article is protected by copyright. All rights reserved. - Regional assessment of medical care provision system by principal component analysis.
Kazuki Ohashi; Arisa Abe; Kensuke Fujiwara; Naoki Nishimoto; Katsuhiko Ogasawara
Journal of family medicine and primary care, 12, 4, 734, 742, Apr. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, INTRODUCTION: The Japanese government has promoted policies ensuring standardized medical care across the secondary medical care areas (SMCAs); however, these efforts have not been evaluated, making the current conditions unclear. Multidimensional indicators could identify these differences; thus, this study examined the regional characteristics of the medical care provision system for 21 SMCAs in Hokkaido, Japan, and the changes from 1998 to 2018. MATERIALS AND METHODS: This study evaluated the characteristics of SMCAs by principal component analysis using multidimensional data related to the medical care provision system. Factor loadings and principal component scores were calculated, with the characteristics of each SMCA visually expressed using scatter plots. Additionally, data from 1998 to 2018 were analyzed to clarify the changes in SMCAs' characteristics. RESULTS: The primary and secondary principal components were Medical Resources and Geographical Factors, respectively. The Medical Resources components included the number of hospitals, clinics, and doctors, and an area's population of older adults, accounting for 65.28% of the total variance. The Geographical Factors components included the number of districts without doctors and the population and a land area of these districts, accounting for 23.20% of the variance. The accumulated proportion of variance was 88.47%. From 1998 to 2018, the area with the highest increase in Medical Resources was Sapporo, with numerous initial medical resources (-9.283 to -10.919). DISCUSSION: Principal component analysis summarized multidimensional indicators and evaluated SMCAs in this regional assessment. This study categorized SMCAs into four quadrants based on Medical Resources and Geographical Factors. Additionally, the difference in principal component scores between 1998 and 2018 emphasized the expanding gap in the medical care provision system among the 21 SMCAs. - Allulose for the attenuation of postprandial blood glucose levels in healthy humans: A systematic review and meta-analysis.
Tani Yuma; Masaaki Tokuda; Naoki Nishimoto; Hideto Yokoi; Ken Izumori
PloS one, 18, 4, e0281150, 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, D-Allulose is a rare sugar that exists in nature. It is a food ingredient with nearly zero calories (<0.4 kcal/g) and has many physiological functionalities such as attenuation of postprandial blood glucose levels, attenuation of postprandial fat mass accumulation, and anti-aging property. This study focused on the postprandial blood glucose changes in healthy humans by a systematic review and meta-analysis. They were chosen because of its importance to a prevention from diabetes. The study objective was to examine acute blood glucose concentrations of healthy humans after the meal with and without allulose. The study collected all D-allulose related studies from various databases. A forest plot of the comparison between an allulose intake group and the control group showed both 5g and 10g intake groups have the significantly smaller area under the curve of postprandial blood glucose levels. It means that D-Allulose attenuates postprandial blood glucose concentrations in healthy humans. As the result, D-Allulose is a valuable blood glucose management tool for healthy humans and diabetes patients. Allulose Diet enables reduction of sucrose intake through Sugar Reformulation in the future diet. - 北海道における多系統萎縮症レジストリ研究 HoRC-MSA2014-2022
松島 理明; 足澤 萌奈美; 工藤 彰彦; 佐久嶋 研; 金谷 泰宏; 西本 尚樹; 澤田 潤; 松岡 健; 久原 真; 上杉 春雄; 南 尚哉; 佐光 一也; 武井 麻子; 玉腰 暁子; 佐藤 典宏; 佐々木 秀直; 矢部 一郎; 北海道保健福祉部健康安全局地域保健課感染症・特定疾患グループ
臨床神経学, 62, 12, 976, 976, (一社)日本神経学会, Dec. 2022
Japanese - 北海道における多系統萎縮症レジストリ研究 HoRC-MSA2014-2022
松島 理明; 足澤 萌奈美; 工藤 彰彦; 佐久嶋 研; 金谷 泰宏; 西本 尚樹; 澤田 潤; 松岡 健; 久原 真; 上杉 春雄; 南 尚哉; 佐光 一也; 武井 麻子; 玉腰 暁子; 佐藤 典宏; 佐々木 秀直; 矢部 一郎; 北海道保健福祉部健康安全局地域保健課感染症・特定疾患グループ
臨床神経学, 62, 12, 976, 976, (一社)日本神経学会, Dec. 2022, [Peer-reviewed]
Japanese - Improved time in range and postprandial hyperglycemia with canagliflozin in combination with teneligliptin: Secondary analyses of the CALMER study.
Kyu Yong Cho; Hiroshi Nomoto; Akinobu Nakamura; Shinichiro Kawata; Hajime Sugawara; Jun Takeuchi; So Nagai; Kazuno Omori; Kazuhisa Tsuchida; Aika Miya; Ikumi Shigesawa; Kenichi Tsuchida; Shingo Yanagiya; Hiraku Kameda; Hiroki Yokoyama; Shinji Taneda; Yoshio Kurihara; Shin Aoki; Naoki Nishimoto; Tatsuya Atsumi; Hideaki Miyoshi
Journal of diabetes investigation, 12, 8, 1417, 1424, Aug. 2021, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, AIMS/INTRODUCTION: We recently reported the beneficial effect of the combination of sodium-glucose cotransporter 2 inhibitor and dipeptidyl peptidase-4 inhibitor on daily glycemic variability in patients with type 2 diabetes mellitus. Additional favorable effects of combination therapy were explored in this secondary analysis. MATERIALS AND METHODS: The CALMER study was a multicenter, open-label, prospective, randomized, parallel-group comparison trial for type 2 diabetes mellitus involving continuous glucose monitoring under meal tolerance tests. Patients were randomly assigned to switch from teneligliptin to canagliflozin (SWITCH group) or to add canagliflozin to teneligliptin (COMB group). The continuous glucose monitoring metrics, including time in target range, were investigated. RESULTS: All 99 participants (mean age 62.3 years; mean glycated hemoglobin 7.4%) completed the trial. The time in target range was increased in the COMB group (71.2-82.7%, P < 0.001). The extent of the reduction in time above target range was significantly larger in the COMB group compared with the SWITCH group (-14.8% vs -7.5%, P < 0.01). Area under the curve values for glucose at 120 min after all meal tolerance tests were significantly decreased in the COMB group compared with the SWITCH group (P < 0.05). CONCLUSIONS: Sodium-glucose cotransporter 2 inhibitor combined with dipeptidyl peptidase-4 inhibitor improved the quality of glycemic variability and reduced postprandial hyperglycemia compared with each monotherapy. - The FibroScan-aspartate aminotransferase score can stratify the disease severity in a Japanese cohort with fatty liver diseases.
Hideki Fujii; Shinya Fukumoto; Masaru Enomoto; Sawako Uchida-Kobayashi; Tatsuo Kimura; Akihiro Tamori; Yuji Nadatani; Shingo Takashima; Naoki Nishimoto; Norifumi Kawada
Scientific reports, 11, 1, 13844, 13844, 05 Jul. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, This study aimed to prove that the FibroScan-aspartate aminotransferase (FAST) scores can be used to stratify disease severity in a Japanese cohort with fatty liver diseases [metabolic dysfunction-associated fatty liver disease (MAFLD) and nonalcoholic fatty liver disease (NAFLD)]. All the participants (n = 2254) underwent liver stiffness measurements and controlled attenuation parameter assessments. We compared the clinical characteristics of the patients with MAFLD and NAFLD using the FAST scores and explored the independent determinants of FAST scores ≥ 0.35, which indicated possible progressive disease. Overall, MAFLD was diagnosed in 789 patients (35.0%), while NAFLD was diagnosed in 618 (27.4%). The proportion of patients that had a condition that suggested progressive liver disease was higher in those with MAFLD than in those with NAFLD [68 (8.6%) vs 48 (7.7%)]. The area under the receiver-operating characteristic curve of the FAST score for diagnosing advanced fibrosis was 0.969 in MAFLD and 0.965 in NAFLD. Multivariate analyses determined that diabetes mellitus, alanine aminotransferase (ALT) levels, fatty liver index, and Fibrosis-4 index independently predict FAST scores ≥ 0.35 in patients with MAFLD. ALT levels had the strongest correlation with the FAST scores (p = 0.7817). The FAST score could stratify the disease severity in the Japanese cohort with fatty liver diseases. - Validation of a two-step approach combining serum biomarkers and liver stiffness measurement to predict advanced fibrosis.
Hideki Fujii; Masaru Enomoto; Shinya Fukumoto; Tatsuo Kimura; Yuji Nadatani; Shingo Takashima; Atsushi Hagihara; Sawako Uchida-Kobayashi; Akihiro Tamori; Naoki Nishimoto; Norifumi Kawada
JGH open : an open access journal of gastroenterology and hepatology, 5, 7, 801, 808, Jul. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, Background and Aim: The Gut and Obesity in Asia Workgroup recently reported that a two-step approach using fibrosis scores followed by liver stiffness measurement (LSM) could accurately detect patients with non-alcoholic fatty liver disease (NAFLD) having advanced fibrosis in low-risk fibrosis populations. This study aimed to validate the utility of this approach using a Japanese health checkup registry. Methods: This cross-sectional study included subjects who underwent a health checkup from 2014 to 2019. Using estimated fibrosis stage measured by LSM as a standard, we calculated the percentage of misclassification from assessments made based on fibrosis scores (NAFLD fibrosis score [NFS] or Fibrosis-4 score [FIB-4]) and LSM, alone or in combination. Results: Of 630 subjects with NAFLD, 4 (0.8%) had advanced fibrosis. In the first-step evaluation, only 21.4-38.0% of subjects needed further testing. This approach was associated with a high specificity of approximately 100% and a negative predictive value of 99.7%. The percentage of misclassification based on NFS or FIB-4 values followed by LSM in all subjects and using LSM after NFS or FIB-4 determination only in subjects with indeterminate/high NFS or FIB-4 values (two-step approach) was 0% and 0.3% and 0.16% and 0.3%, respectively. In addition, very few false negatives occurred for both NFS and FIB-4. Conclusion: The two-step approach helps to identify the subjects with NAFLD who have advanced fibrosis during a routine health checkup and is associated with only a few false negatives. - Patient characteristics affecting knowledge of the possibility of surgical reconstruction for rheumatoid hand and wrist deformities.
Makoto Motomiya; Naoki Nishimoto; Atsushi Urita; Daisuke Kawamura; Yuka Shimizu; Norimasa Iwasaki
Modern rheumatology, 31, 3, 614, 620, May 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: We aimed to investigate patient characteristics affecting their knowledge of surgical reconstruction for rheumatoid hand and wrist deformities, and to investigate such characteristics affecting their hope of receiving hand surgery if patients with rheumatoid arthritis (RA) knew surgical reconstruction options. METHODS: We carried out a questionnaire survey for all patients with RA who came to our outpatient department of rheumatology. Multivariate logistic regression analysis was performed to examine significant characteristics associated with the knowledge of surgical reconstruction and patients' hope of receiving hand surgery. RESULTS: In total, 687 patients were evaluated in this study and 337 (49%) reported knowledge about surgical reconstruction. A multivariate logistic regression analysis showed that patients with good control of disease activity and with long-lasting hand and wrist deformities were significantly associated with having knowledge of surgical reconstruction. Among the 337 patients with knowledge, only 122 (36%) expressed a hope of receiving hand surgery. The statistical analysis showed that younger age and surgical history were significantly associated with the hope of receiving surgery. CONCLUSION: Surgeons and rheumatologists should enlighten patients about the importance of hand surgery to achieve functional remission in this new era of treatment for patients with RA. - Efficacy and safety of sodium RISedronate for glucocorticoid-induced OsTeoporosis with rheumaTOid arthritis (RISOTTO study): A multicentre, double-blind, randomized, placebo-controlled trial.
Yuichiro Fujieda; Tetsuya Horita; Naoki Nishimoto; Kazuhide Tanimura; Yoshiharu Amasaki; Hideki Kasahara; Shin Furukawa; Tsuyoshi Takeda; Shinji Fukaya; Kazuo Matsui; Akito Tsutsumi; Akira Furusaki; Akira Sagawa; Kou Katayama; Kaoru Takeuchi; Kazuaki Katsumata; Takashi Kurita; Peter Shane; Masaru Kato; Kenji Oku; Shinsuke Yasuda; Masahiko Takahata; Norimasa Iwasaki; Tatsuya Atsumi
Modern rheumatology, 31, 3, 593, 599, May 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: No evidence has shown the efficacy of Sodium Risedronate (Risedronate) for glucocorticoid-induced osteoporosis (GIO) in patients with Rheumatoid arthritis (RA). The aim of this study was to explore the effectiveness and safety of Risedronate for GIO complicated with RA. METHODS: This was a six-month randomized, double-blind, placebo-controlled trial of 95 patients with GIO complicated with RA from 19 centers. The primary endpoint was the change from baseline in lumbar spine bone mineral density (L-BMD). Secondary endpoints included changes in femoral neck and total hip BMD and bone turnover markers, as well as rheumatoid arthritis Disease Activity Score with 28-joint counts. Incident of non-traumatic spine fractures and adverse events were tracked as safety endpoints. RESULTS: Increase in L-BMD was significantly greater in the Risedronate group compared to the Placebo group (Risedronate: 3.49% [95% CI: 1.92-5.05] vs Placebo: 0.12% [95% CI: -2.07 to 2.30], p < .0001). No significant difference was found in the femoral neck and total hip BMD. Although adverse events were observed in 28 patients, none were considered serious. Non-traumatic vertebral fractures were identified in 10 patients. CONCLUSION: Risedronate was effective in increasing L-BMD and was well tolerated in patients with GIO complicated with RA. - Multiple system atrophy in Hokkaido, Japan: a prospective registry study of natural history and symptom assessment scales followed for 5 years.
Masaaki Matsushima; Ichiro Yabe; Ken Sakushima; Yasuhiro Kanatani; Naoki Nishimoto; Takeshi Matsuoka; Jun Sawada; Haruo Uesugi; Kazuya Sako; Asako Takei; Akiko Tamakoshi; Shun Shimohama; Norihiro Sato; Seiji Kikuchi; Hidenao Sasaki
BMJ open, 11, 2, e045100, 08 Feb. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: Multiple system atrophy (MSA) is a refractory neurodegenerative disease, but novel treatments are anticipated. An accurate natural history of MSA is important for clinical trials, but is insufficient. This regional registry was launched to complement clinical information on MSA. SETTING: Patient recruitment started in November 2014 and is ongoing at the time of submission. The number of participating facilities was 66. Postal surveys were sent to medical facilities and patients with MSA in Hokkaido, Japan. PARTICIPANTS: After obtaining written consent from 196 participants, 184 overview surveys and 115 detailed surveys were conducted. PRIMARY AND SECONDARY OUTCOME MEASURES: An overview survey evaluated conformity to diagnostic criteria and a detailed survey implemented an annual assessment based on the Unified Multiple System Atrophy Rating Scale (UMSARS). RESULTS: At the time of registration, 58.2% of patients were diagnosed with cerebellar symptoms predominant type MSA (MSA-C) and 29.9% were diagnosed with parkinsonism predominant type MSA (MSA-P). UMSARS Part Ⅳ score of 4 or 5 accounted for 53.8% of participants. The higher the UMSARS Part Ⅳ score, the higher the proportion of MSA-P. At baseline, levodopa was used by 69 patients (37.5%) and the average levodopa dose was 406.7 mg/day. The frequency of levodopa use increased over time. Eleven cases changed from MSA-C to MSA-P during the study, but the opposite was not observed. Information about survival and causes of death was collected on 54 cases. Half of deaths were respiratory-related. Sudden death was recorded even in the group with UMSARS Part Ⅳ score of 1. CONCLUSIONS: This study is the first large-scale prospective MSA cohort study in Asia. MSA-C was dominant, but the use of antiparkinsonian drugs increased over the study period. Changes from MSA-C to MSA-P occurred, but not vice versa. - Development of a Novel Algorithm to Detect Atrial Fibrillation Using an Automated Blood Pressure Monitor With an Irregular Heartbeat Detector.
Makoto Ishizawa; Takahisa Noma; Takahiro Izumi; Ryosuke Tani; Tomoko Inoue; Eriko Nasu; Atsushi Tobiume; Yusuke Hasui; Shota Yokoyama; Hideyuki Hamaya; Shohei Ishikawa; Keiji Matsunaga; Ryo Kawakami; Kumi Konishi; Yuichi Miyake; Kaori Ishikawa; Teppei Tsuji; Kazushi Murakami; Naoki Nishimoto; Hiroyuki Kitajima; Tetsuo Minamino
Circulation journal : official journal of the Japanese Circulation Society, 83, 12, 2428, 2433, 25 Nov. 2019, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, BACKGROUND: Atrial fibrillation (AF), which contributes to an increased risk of stroke, frequently remains undetected, suggesting an unmet need for easier and more reliable AF screening. The reports on screening AF using an Omron blood pressure (BP) monitor with an irregular heartbeat (IHB) detector show inconsistent results, so the aim of this study was to develop a novel algorithm to accurately diagnose AF with 3 BP measurements using an Omron automated BP monitor with IHB detector.Methods and Results:In total, 303 general cardiac patients were included. Real-time single-lead ECG revealed AF in 44 patients. BP measurement was performed 3 times per patient using the Omron BP monitor HEM-907, and the number of IHBs detected was recorded. Based on these data, we developed the following algorithm: ≥1 IHB is detected during at least 2 of 3 BP measurements and the maximum number of IHBs detected is ≥2. Using this algorithm, we achieved a sensitivity of 95.5% and specificity of 96.5%, for diagnosing AF. CONCLUSIONS: The novel algorithm with 3 BP measurements using the Omron automated BP monitor with IHB detector showed high sensitivity and specificity for diagnosing AF in general cardiac patients. - 包絡分析法を用いた将来推計患者数に基づく医療資源の効率性評価
谷川 琢海; 藤原 健祐; 西本 尚樹; 大場 久照; 小笠原 克彦
医療情報学連合大会論文集, 39回, 199, 200, (一社)日本医療情報学会, Nov. 2019
Japanese - 包絡分析法を用いた将来推計患者数に基づく医療資源の効率性評価
谷川 琢海; 藤原 健祐; 西本 尚樹; 大場 久照; 小笠原 克彦
医療情報学連合大会論文集, 39回, 256, 256, (一社)日本医療情報学会, Nov. 2019
Japanese - Behavior problems and dysfunctional parenting: Cross-sectional study in Japan.
Hiromi Suzuki; Takeshi Yoda; Kanae Kanda; Naoki Nishimoto; Nobuyuki Miyatake; Yukihiko Konishi; Tomoko Nishida; Katsunori Yokoyama; Takashi Kusaka; Tomohiro Hirao
Pediatrics international : official journal of the Japan Pediatric Society, 61, 11, 1096, 1102, Nov. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: The Japanese government has established a law encouraging early detection and treatment of developmental disorders in children. Child behavior problems (CBP) tend to be recognized at school as a result of developmental disorders. The aim of this study was to identify factors associated with CBP in Japan. We hypothesized that factors other than developmental disorders are important in explaining CBP. METHODS: The study was conducted between February and March 2015. Parents of 3,515 children aged 2-5 years attending one of 34 public nursery schools in Takamatsu, Kagawa, Japan received self-administered questionnaires addressing parental socioeconomic factors, mental health, parenting style (i.e. hostile, overreactive, or lax), developmental disorders in children, and CBP. A multiple regression analysis was applied to explore associations between CBP and possible factors. RESULTS: Overall, 1,410 mothers were eligible to participate in the study. Children diagnosed with developmental disorders accounted for 7.8% of the sample, while on the Eyberg Child Behavior Inventory 17% of children had behavior problems needing clinical intervention. After adjustment for confounding factors, as well as for the diagnosis of developmental disorders, poor mental status and all three dysfunctional parenting styles had strong associations with CBP, and hostile, overreactive, and lax parenting had standardized β-values (β) of 0.29, 0.28, and 0.15, respectively (P < 0.01). A problematic relationship between the parents was also significantly associated with CBP (β = -0.29, P < 0.01). CONCLUSION: When CBP are identified, parenting skills, mental health status and parental relationships should be considered along with the possibility of developmental disorders in the development of interventions. - 放射線技術学用語集の電子化に向けて【後編】学術調査研究班から用語集管理小委員会までの活動
谷川原 綾子; 辻 真太朗; 福田 晋久; 西本 尚樹; 谷川 琢海; 川眞田 実; 内田 幸司; 小笠原 克彦; 用語集管理小委員会
日本放射線技術学会雑誌, 75, 9, 1101, 1108, (公社)日本放射線技術学会, Sep. 2019
Japanese - 放射線技術学用語集の電子化に向けて【前編】日本放射線技術学会における専門用語集構築の変遷と歴史
辻 真太朗; 谷川原 綾子; 福田 晋久; 西本 尚樹; 谷川 琢海; 川眞田 実; 内田 幸司; 小笠原 克彦; 用語集管理小委員会
日本放射線技術学会雑誌, 75, 8, 854, 860, (公社)日本放射線技術学会, Aug. 2019
Japanese - HOMA-IR: An independent predictor of advanced liver fibrosis in nondiabetic non-alcoholic fatty liver disease.
Hideki Fujii; Kento Imajo; Masato Yoneda; Takashi Nakahara; Hideyuki Hyogo; Hirokazu Takahashi; Tasuku Hara; Saiyu Tanaka; Yoshio Sumida; Yuichiro Eguchi; Kazuaki Chayama; Atsushi Nakajima; Naoki Nishimoto; Norifumi Kawada
Journal of gastroenterology and hepatology, 34, 8, 1390, 1395, Aug. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND AND AIM: Although non-alcoholic fatty liver disease (NAFLD) is common in the general population, identifying patients with advanced fibrosis remains a challenge. We investigated whether the homeostasis model assessment parameter of insulin resistance (HOMA-IR), an index of IR and one of the most important metabolic factors, is an independent predictive factor for advanced fibrosis in nondiabetic patients with NAFLD. METHODS: This was a retrospective, cross-sectional multicenter study. We included 361 patients with biopsy-proven NAFLD who had not been diagnosed with type 2 diabetes mellitus: 175 (48%) were women and 48 (13%) had advanced fibrosis. We used simple random sampling; the sampling ratio of the estimation and validation groups was 7:3. A logistic model was constructed for both the estimation and validation groups. The explanatory variables were age ≥ 49 years, sex (women), body mass index ≥ 26.7 kg/m2 , the presence of hypertension, presence of dyslipidemia, fasting plasma glucose level ≥ 98 mg/dL, fasting immune reactive insulin level ≥ 12.0 μU/mL, and HOMA-IR ≥ 2.90. The median HOMA-IR of the patients was 2.88 (interquartile range: 2.1-4.8). RESULTS: In the estimation group, univariate and multivariate analyses showed that age, dyslipidemia, and HOMA-IR were independent predictors of advanced fibrosis. In the validation group, only age and HOMA-IR were found to be independent predictors of advanced fibrosis. CONCLUSIONS: Homeostasis model assessment parameter of insulin resistance was an independent predictor of advanced liver fibrosis in nondiabetic patients with NAFLD. Given that most patients with NAFLD are nondiabetic, it is important to set goals with respect to improving IR to subsequently reduce liver fibrosis. - Fetal facial expressions in small-for-gestational-age and growth-restricted fetuses.
Nobuhiro Mori; Mohamed Ahmed Mostafa AboEllail; Chiaki Tenkumo; Kenji Kanenishi; Naoki Nishimoto; Toshiyuki Hata
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 32, 9, 1426, 1432, May 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: To evaluate the frequencies of fetal facial expressions among appropriate-for-gestational-age (AGA), small-for-gestational-age (SGA), and growth-restricted (FGR) fetuses. METHODS: Four-dimensional (4D) ultrasound was used to examine the facial expressions of 50 AGA, 25 SGA, and six FGR fetuses between 28 and 35 weeks of gestation. The frequencies of seven facial expressions during 15-minute recordings were assessed. Comparison of facial expressions among the three groups was performed. RESULTS: Mouthing was the commonest facial expression at 28-35 weeks, and the frequency of mouthing was significantly higher than those of the other six facial expressions in AGA fetuses. Mouthing was the most frequent facial expression, but there was no significant difference in the frequency among mouthing, smiling and blinking in SGA fetuses. Moreover, mouthing displayed a significantly higher frequency than the other facial expressions, except for yawning, smiling, and blinking in FGR fetuses. However, there was no significant difference in the frequency of each facial expression among the three groups. CONCLUSIONS: Our results suggest that the frequencies of fetal facial expressions are not decreased in either SGA or FGR pregnancies. The absence of a decrease in the frequency of each fetal expression in FGR fetuses may be due to increased brain blood flow because of the brain-sparing effect. Moreover, accelerated maturation and development of the brain function, especially the central dopamine system, might be suspected in SGA and FGR fetuses. - Chest Compression Depth and Rate - Effect on Instructor Visual Assessment of Chest Compression Quality.
Katsuya Nagafuchi; Toru Hifumi; Naoki Nishimoto; Yutaka Kondo; Kei Yoshikawa; Taku Iwami; Yasuhiro Kuroda
Circulation journal : official journal of the Japanese Circulation Society, 83, 2, 418, 423, 25 Jan. 2019, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, BACKGROUND: The aim of the present study was to determine whether instructors could accurately assess chest compression quality visually, considering the association between chest compression depth and rate. Methods and Results: In this prospective, observational study, the quality of chest compressions performed by a simulated actor in a video was visually assessed by certified instructors. The film consisted of 14 case scenarios, each including a combination of depth (2 patterns: adequate, 5-6 cm; and inadequate, <5 cm) and rate (7 categories: compressions 90-150 times/min in increments of 10 times/min). The participants evaluated whether the compression depth was adequate, deep, or inadequate; and whether the compression rate was appropriate, fast, or slow. Of 198 instructors, 56% of participants misidentified adequate depth as deep at a chest compression rate of 120/min (the tendency toward this response increased as chest compression rate increased), and 64.1% of participants incorrectly determined 130/min to be appropriate. On generalized linear mixed-effects model analysis, perceived chest compression depth and rate were significant factors for a correct response (P<0.01, both). A significant interaction between chest compression depth and rate was observed (P<0.01). CONCLUSIONS: In the visual assessment of chest compression quality, recognition of chest compression depth was closely associated with compression rate. Misidentification of adequate chest compression depth as deep increased as the compression rate increased. - Wearable sensors reveal that parents do not know children's sleep time
Hiromi Suzuki; Naoki Nishimoto; Kanae Kanda; Yukihiko Konish; Takashi Kusaka; Tomohiro Hirao; Nobuyuki Miyatake
22, 1, 1, 8, 2019, [Peer-reviewed]
English, Scientific journal - [The Influence for Image Quality of Diffusion Weighted Image by Gradient Coil Systems].
Tatsuya Yamasaki; Kazuo Ogawa; Takashi Ishimori; Naoki Nishimoto
Nihon Hoshasen Gijutsu Gakkai zasshi, 75, 4, 314, 321, 2019, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, The purpose of this study was to evaluate the influence for image quality of diffusion weighted image (DWI) by gradient coil systems (two single gradient systems and a dual gradient system). We obtained DWIs of a phantom and three volunteer brains, changing gradient coil systems and echo time (TE) from configurable shortest TE to 130 ms. Image quality of DWI was evaluated by signal to noise ratio (SNR), image distortion, susceptibility artifact, and visual evaluation. SNR of dual gradient system and configurable shortest TE was the highest in phantom study, but there was no difference for SNR of volunteer brain images by each gradient coil system in visual evaluation. Image distortion of single gradient system with low gradient amplitude was the worst in phantom study, and the score of visual evaluation in susceptibility artifact was significantly lower than other gradient coil systems. Dual gradient system was low influence to image distortion and susceptibility artifact. In conclusion, using dual gradient system and configurable shortest TE is recommended for less distortion, low susceptibility artifact, and high SNR image. - [Toward Launching Electronic Terminology Services in Radiological Technology-From the Academic Research to the Activity of the Subcommittee in JSRT].
Ayako Yagahara; Shintaro Tsuji; Akihisa Fukuda; Naoki Nishimoto; Takumi Tanikawa; Minoru Kawamata; Koji Uchida; Katsuhiko Ogasawra
Nihon Hoshasen Gijutsu Gakkai zasshi, 75, 9, 1101, 1108, 2019, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal - Mild decrease in heart rate during early phase of targeted temperature management following tachycardia on admission is associated with unfavorable neurological outcomes after severe traumatic brain injury: a post hoc analysis of a multicenter randomized controlled trial.
Akihiko Inoue; Toru Hifumi; Yasuhiro Kuroda; Naoki Nishimoto; Kenya Kawakita; Susumu Yamashita; Yasutaka Oda; Kenji Dohi; Hitoshi Kobata; Eiichi Suehiro; Tsuyoshi Maekawa
Critical care (London, England), 22, 1, 352, 352, 19 Dec. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: The association between isolated admission heart rate (HR) and prognosis has been discussed, but not that between gross HR change and neurological outcome in patients with severe traumatic brain injury (TBI). In the acute phase of severe TBI, HR is influenced by several factors (e.g., pain, sympathetic activation, hypovolemia, fever, body temperature). Therefore, admission HR and gross HR change should be examined in patients with TBI treated with a well-designed protocol, such as was done in the Brain Hypothermia (B-HYPO) Study. METHODS: This was a post hoc analysis of the B-HYPO Study, which was conducted as a prospective, multicenter, randomized controlled trial in patients with severe TBI receiving mild therapeutic hypothermia (MTH; 32.0 °C-34.0 °C) or fever control (35.5 °C-37.0 °C) in Japan. Patients with MTH were examined, and HR change (%HR) in the early MTH phase was calculated as follows: [admission HR - HR at day 1]/admission HR × 100. Patients were divided into six groups, using admission HR (< 80, 80-99, ≤ 100) and median of %HR; i.e., group (Admission HR < 80 and %HR ≥ 18.6); group (Admission HR < 80 and %HR < 18.6); group (Admission HR 80-99 and %HR ≥ 18.6); group (Admission HR 80-99 and %HR < 18.6); group (Admission HR ≥100 and %HR ≥ 18.6); and group (Admission HR ≥100 and %HR < 18.6). The primary outcome was an adjusted predicted probability of unfavorable neurological outcome at 6 months after TBI according to Glasgow Outcome Scale score, which is a measure of functional recovery and defined as severe disability, persistent vegetative state, and death. RESULTS: Overall, 79 patients with MTH (52.7% of the original trial) were examined; among these, unfavorable neurological outcomes were observed in 53.2%. Among all the groups, group (Admission HR ≥100 and %HR < 18.6) exhibited the highest proportion of unfavorable outcomes, and 82.3% of patients had an adjusted predicted probability of unfavorable outcomes, whereas those in group (Admission HR < 80 and %HR ≥ 18.6) developed only 22.8% (p = 0.04). CONCLUSIONS: Mild HR decrease during the early phase of targeted temperature management following tachycardia at admission can be associated with unfavorable neurological outcomes after severe TBI. - 北海道の将来における医療資源の適正配置 将来推計人口と推計傷病別患者数のシミュレーション分析
谷川 琢海; 藤原 健祐; 西本 尚樹; 大場 久照; 小笠原 克彦
医療情報学連合大会論文集, 38回, 1094, 1096, (一社)日本医療情報学会, Nov. 2018
Japanese - P1936Multiple measurements with an automated blood pressure monitor can detect atrial fibrillation with high sensitivity and specificity in general cardiac patients
M Ishizawa; T Inoue; A Tobiume; Y Hasui; S Yokoyama; S Ishikawa; K Matsunaga; K Mantani; Y Miyake; K Ishikawa; T Tsuji; K Murakami; N Nishimoto; T Noma; T Minamino
European Heart Journal, 39, suppl{\_}1, Oxford University Press ({OUP}), Aug. 2018
Scientific journal - Characteristic findings of high-grade cervical intraepithelial neoplasia or more on magnifying endoscopy with narrow band imaging.
Kunihisa Uchita; Kenji Kanenishi; Koki Hirano; Hideki Kobara; Noriko Nishiyama; Ai Kawada; Shintaro Fujihara; Emi Ibuki; Reiji Haba; Yohei Takahashi; Yuka Kai; Kenji Yorita; Hirohito Mori; Jun Kunikata; Naoki Nishimoto; Toshiyuki Hata; Tsutomu Masaki
International journal of clinical oncology, 23, 4, 707, 714, Aug. 2018, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, BACKGROUND: Colposcopy, which is a standard modality for diagnosing cervical intraepithelial neoplasia (CIN), can have limited accuracy owing to poor visibility. Flexible magnifying endoscopy with narrow band imaging (ME-NBI) has excellent diagnostic accuracy for early gastrointestinal neoplasms and is expected to be highly useful for CIN diagnosis. This study aimed to determine the characteristic findings and evaluate the diagnostic ability of ME-NBI for lesions ≥ CIN 3. METHODS: A well-designed prospective diagnostic case series conducted at multiple tertiary-care centers. A total of 24 patients who underwent cervical conization with a preoperative diagnosis of high-grade squamous cell intraepithelial lesions (HSILs) or lesions ≥ CIN 3 were enrolled. Prior to conization, still images and video of ME-NBI were captured to investigate the cervical lesions. The images were reviewed based on histological examination of the resected specimens. RESULTS: The NBI-ME images revealed the following abnormal findings: (1) light white epithelium (l-WE), (2) heavy white epithelium (h-WE), and (3) atypical intra-epithelial papillary capillary loop (IPCL). Pathological examination of the resected specimens confirmed cervical lesions ≥ CIN 3 in 21 patients. The ME-NBI findings were classified into four groups: l-WE, l-WE with atypical IPCL, h-WE, and h-WE with atypical IPCL, at rates of 0, 23.8, 9.5, and 66.7%, respectively. Additionally, all 3 patients with micro-invasive carcinoma showed a strong irregularity of IPCLs. CONCLUSION: The lesions ≥ CIN 3 demonstrated characteristic ME-NBI findings of h-WE alone, or l-/h-WE with atypical micro-vessels. This study indicates that ME-NBI may have novel value for CIN diagnosis. - Construction of mammographic examination process ontology using bottom-up hierarchical task analysis.
Ayako Yagahara; Yuki Yokooka; Guoqian Jiang; Shintarou Tsuji; Akihisa Fukuda; Naoki Nishimoto; Kunio Kurowarabi; Katsuhiko Ogasawara
Radiological physics and technology, 11, 1, 73, 81, Mar. 2018, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Describing complex mammography examination processes is important for improving the quality of mammograms. It is often difficult for experienced radiologic technologists to explain the process because their techniques depend on their experience and intuition. In our previous study, we analyzed the process using a new bottom-up hierarchical task analysis and identified key components of the process. Leveraging the results of the previous study, the purpose of this study was to construct a mammographic examination process ontology to formally describe the relationships between the process and image evaluation criteria to improve the quality of mammograms. First, we identified and created root classes: task, plan, and clinical image evaluation (CIE). Second, we described an "is-a" relation referring to the result of the previous study and the structure of the CIE. Third, the procedural steps in the ontology were described using the new properties: "isPerformedBefore," "isPerformedAfter," and "isPerformedAfterIfNecessary." Finally, the relationships between tasks and CIEs were described using the "isAffectedBy" property to represent the influence of the process on image quality. In total, there were 219 classes in the ontology. By introducing new properties related to the process flow, a sophisticated mammography examination process could be visualized. In relationships between tasks and CIEs, it became clear that the tasks affecting the evaluation criteria related to positioning were greater in number than those for image quality. We developed a mammographic examination process ontology that makes knowledge explicit for a comprehensive mammography process. Our research will support education and help promote knowledge sharing about mammography examination expertise. - Correlation between serum galectin-9 levels and liver fibrosis.
Koji Fujita; Toshiro Niki; Takako Nomura; Kyoko Oura; Tomoko Tadokoro; Teppei Sakamoto; Joji Tani; Hirohito Yoneyama; Asahiro Morishita; Noriyuki Kuroda; Takeshi Arai; Naoki Nishimoto; Takashi Himoto; Mitsuomi Hirashima; Tsutomu Masaki
Journal of gastroenterology and hepatology, 33, 2, 492, 499, Feb. 2018, [International Magazine]
English, Scientific journal, BACKGROUND AND AIM: Chronic liver diseases progress from chronic inflammation to fibrosis to tumorigenesis. Galectin-9, a β-galactoside-specific animal lectin, is indicated to contribute to all three steps of progression. The aim of this study was to determine which of the three steps was most dominant in elevating the serum galectin-9 concentration and to test the possibility of galectin-9 as a serum biomarker. METHODS: Japanese patients with chronic hepatitis, liver cirrhosis, hepatocellular carcinoma (HCC), non-alcoholic fatty liver disease, or alcoholic liver disease who provided informed consent were enrolled in this study. Serum galectin-9 levels were measured using a sandwich ELISA. Multiple regression analyses were performed using ezr to identify factors that determined serum galectin-9 concentration. RESULTS: One hundred one patients with 50 of chronic hepatitis and 51 of liver cirrhosis were enrolled; the cohort included 45 cases of hepatitis C virus infection, 13 cases of hepatitis B virus infection, and 46 cases with HCC-related complications. The median serum galectin-9 concentration was 77.54 pg/mL (interquartile range: 18.89-241.9 pg/mL). Multiple linear regression analyses proved Fibrosis-4 index and aspartate aminotransferase to platelet ratio index, indexes of liver fibrosis, were able to predict the serum galectin-9 levels with statistical significance. A multiple logistic regression analysis determined 10 pg/mL increase in the serum galectin-9 concentration presented an odds ratio of 3.90 for liver fibrosis progression. CONCLUSIONS: The serum galectin-9 concentration represents a potential biomarker of liver fibrosis in patients with chronic liver diseases, regardless of chronic inflammation or the presence of HCC complications. Furthermore, higher serum galectin-9 levels are a predictor for liver fibrosis progression. - Appling Text-mining to Extracting Technical Terms from Textbooks-Toward Updating the Terminology in the Field of Radiology Technology-
辻真太朗; 谷川原綾子; 福田晋久; 谷川琢海; 川眞田実; 西本尚樹; 島井健一郎; 星野修平; 小笠原克彦
日本放射線技術学会雑誌, 74, 8, 757‐768(J‐STAGE), 768, 2018, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, Although terminology requires continuous consideration of recorded technical terms, extracting these terms manually is difficult, because the number of recorded terms is constantly increasing. Text-mining acquires information from numerous documents, and is capable of extracting technical terms. The purpose of this study is to extract candidate terms using text-mining toward updating the terminology of Japanese society of radiological technology (JSRT). First, the subjects for this study were textbooks published by the JSRT, and morphological analysis was conducted, which is an analysis to break the books up into meaningful words. Additionally, index terms of textbooks were extracted. Second, we observed overlaps between the JSRT technical terms and the terms obtained from the morphological analysis and the indexes of textbooks and the extracted terms were absent in the JSRT terminology. The overlap was 53.6% (3090/5770 terms). The terms, "imaging technology for magnetic resonance" and "information and system in radiological technology" were missing from the JSRT terminology. From these results, it was estimated that half number of the JSRT technical terms were changing with time. This study demonstrated that text mining showed the differences between old and new technical terms. - 北海道の将来における患者受療行動予測分析 未来に向けた医療資源の適正配置に向けて
谷川 琢海; 大場 久照; 西本 尚樹; 小笠原 克彦
医療情報学連合大会論文集, 37回, 317, 319, (一社)日本医療情報学会, Nov. 2017
Japanese - 症例登録データベース事業に対する登録支援システムの現状と今後 登録情報の流用性の現状 項目標準化の課題
横井 英人; 西本 尚樹; 谷川原 綾子
医療情報学連合大会論文集, 37回, 156, 158, (一社)日本医療情報学会, Nov. 2017
Japanese - 正規化処理を利用した臨床検査値単位とCDISC SDTMのマッピング
西本 尚樹; 田村 菜穂美; 國方 淳; 谷川原 綾子; 赤堀 澄子; 十河 智昭; 谷 佑馬; 横井 英人
医療情報学連合大会論文集, 37回, 782, 783, (一社)日本医療情報学会, Nov. 2017
Japanese - 医療機器不具合用語集における定義文記載法の標準化に向けた表記パターン分析
谷川原 綾子; 西本 尚樹; 福田 晋久; 辻 真太郎; 谷川 琢海; 小笠原 克彦; 横井 英人
医療情報学連合大会論文集, 37回, 1192, 1193, (一社)日本医療情報学会, Nov. 2017
Japanese - Role of the Low-Density Lipoprotein-Cholesterol/High-Density Lipoprotein-Cholesterol Ratio in Predicting Serial Changes in the Lipid Component of Coronary Plaque.
Ryo Kawakami; Ichiro Matsumoto; Motoi Shiomi; Mizuki Kurozumi; Yuichi Miyake; Makoto Ishizawa; Kaori Ishikawa; Kazushi Murakami; Takahisa Noma; Yuichiro Takagi; Naoki Nishimoto; Tetsuo Minamino
Circulation journal : official journal of the Japanese Circulation Society, 81, 10, 1439, 1446, 25 Sep. 2017, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, BACKGROUND: The lipid component of coronary plaques is associated with their vulnerability. The aim of this study was to investigate which coronary risk factors were relevant in predicting serial changes in the lipid component of coronary plaques as evaluated by integrated backscatter intravascular ultrasound (IB-IVUS).Methods and Results:We enrolled 104 patients who underwent IB-IVUS-guided percutaneous coronary intervention (PCI) and were followed up with repeat IB-IVUS 6 months later. We investigated the serial changes in the plasma lipoprotein levels and the percentage of the lipid component of coronary plaques on IB-IVUS. In the multivariate linear regression analysis, the low-density lipoprotein-cholesterol/high-density lipoprotein-cholesterol (L/H) ratio independently had a significant fixed effect with the percentage of the lipid component of coronary plaques at the time of PCI. In addition, the change in the L/H ratio at the 6-month follow-up was significantly associated with that in the lipid component of coronary plaques (regression coefficient, 9.645; 95% CI: 5.814-13.475; P<0.0001); furthermore, this change was also observed in patients with an LDL-C <100 mg/dL. CONCLUSIONS: The L/H ratio was the most relevant parameter in predicting the lipid component of coronary plaques. Furthermore, strict management of the L/H ratio may reduce this lipid component, even in patients with an LDL-C <100 mg/dL. - The authors respond.
Hiroaki Takada; Toru Hifumi; Naoki Nishimoto
The American journal of emergency medicine, 35, 8, 1196, 1197, Aug. 2017, [International Magazine]
English - Comparison of submucosal tunneling biopsy versus EUS-guided FNA for gastric subepithelial lesions: a prospective study with crossover design.
Hideki Kobara; Hirohito Mori; Naoki Nishimoto; Shintaro Fujihara; Noriko Nishiyama; Maki Ayaki; Tatsuo Yachida; Tae Matsunaga; Taiga Chiyo; Nobuya Kobayashi; Koji Fujita; Kiyohito Kato; Hideki Kamada; Makoto Oryu; Kunihiko Tsutsui; Hisakazu Iwama; Reiji Haba; Tsutomu Masaki
Endoscopy international open, 5, 8, E695-E705, Aug. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND AND STUDY AIMS : Endoscopic ultrasound-guided fine needle aspiration (FNA) for gastrointestinal subepithelial lesions (SELs) has limited diagnostic accuracy due to technical problems and small lesion size. We previously reported a novel submucosal tunneling biopsy (STB) technique for sampling SELs. This study aimed to evaluate the diagnostic ability and safety of STB compared to that of FNA for SELs. PATIENTS AND METHODS : The study was a non-randomized, prospective comparative study with crossover design in patients with endoluminal gastric SELs. Forty-three patients, including 29 cases with lesions < 2 cm were enrolled. A crossover design with 2 intervention stages (Group A: FNA followed by STB for 23 SELs, Group B: STB followed by FNA for 20 SELs) was implemented. The primary outcome was the diagnostic yield (DY). Secondary outcomes were technical success rate, procedure time, complication rate, and sample quality. RESULTS : The DY of STB was significantly higher than that of FNA (100 % vs. 34.8 %; P < 0.0001) in group A, including 100 % in overall STB. The technical success rate of STB was significantly higher than that of FNA (100 % vs. 56.5 %; P = 0.0006), whereas the median procedure time of STB was significantly longer than that of FNA (37 minutes vs. 18 minutes; P < 0.0001). The median specimen area of STB samples was markedly larger than that of FNA samples (5.54 mm 2 vs. 0.69 mm 2 ; P < 0.001). No complications occurred in either method. CONCLUSIONS: STB had significantly superior diagnostic ability and a more adequate sample quality than FNA for endoluminal gastric SELs, indicating the suitability of STB for small SELs. CLINICAL TRIAL REGISTRATION: UMIN 000006754. - Linezolid versus vancomycin for nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus in the elderly: A retrospective cohort analysis: Effectiveness of linezolid in the elderly.
Hiroaki Takada; Toru Hifumi; Naoki Nishimoto; Takashi Kanemura; Hayato Yoshioka; Ichiro Okada; Nobuaki Kiriu; Junichi Inoue; Yuichi Koido; Hiroshi Kato
The American journal of emergency medicine, 35, 2, 245, 248, Feb. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: Several reports have compared the efficacy of linezolid (LZD) in Methicillin-resistant Staphylococcus aureus (MRSA) infections with that of vancomycin (VCM); however, these two antibiotics for the treatment of nosocomial MRSA pneumonia in elderly patients has not been well evaluated. The purpose of this study is to evaluate the efficacy and safety of LZD compared with VCM for the treatment of elderly patients with nosocomial MRSA pneumonia in a retrospective chart review of a cohort. METHODS: We included 28 consecutive patients aged ≥65years hospitalized with a confirmed diagnosis of MRSA pneumonia and treated with LZD (n=11) or VCM (n=17) between November 2010 and May 2015. We collected patient, disease, and laboratory data. The primary outcome was 30-day mortality. The secondary outcomes were the sequential organ failure assessment (SOFA) total, respiratory, renal, coagulation, hepatic, cardiovascular, and central nervous system scores on days 1, 3, 7, and 14. RESULTS: There were no significant differences between the two groups with regard to baseline characteristics. The 30-day mortality rate was significantly lower in the LZD group than in the VCM group (0% vs. 41%, P=.02). The SOFA total score on days 3, 7, and 14 were significantly lower those at baseline in the LZD group (P<.05). The SOFA respiratory score on days 14 was also significantly lower than baseline in the LZD group (P<.05). CONCLUSION: LZD may be more efficacious than VCM for treating elderly patients with nosocomial MRSA pneumonia. - 7. Ethics in Clinical Research (2)
Nishimoto Naoki; Ogasawara Katsuhiko
Japanese Journal of Radiological Technology, 73, 1, 69, 77, Japanese Society of Radiological Technology, 2017
Japanese - Apoptosis inhibitor of macrophage depletion decreased M1 macrophage accumulation and the incidence of cardiac rupture after myocardial infarction in mice.
Shohei Ishikawa; Takahisa Noma; Hai Ying Fu; Takashi Matsuzaki; Makoto Ishizawa; Kaori Ishikawa; Kazushi Murakami; Naoki Nishimoto; Akira Nishiyama; Tetsuo Minamino
PloS one, 12, 11, e0187894, 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Cardiac rupture is an important cause of death in the acute phase after myocardial infarction (MI). Macrophages play a pivotal role in cardiac remodeling after MI. Apoptosis inhibitor of macrophage (AIM) is secreted specifically by macrophages and contributes to macrophage accumulation in inflamed tissue by maintaining survival and recruiting macrophages. In this study, we evaluated the role of AIM in macrophage accumulation in the infarcted myocardium and cardiac rupture after MI. METHODS AND RESULTS: Wild-type (WT) and AIM‒/‒ mice underwent permanent left coronary artery ligation and were followed-up for 7 days. Macrophage accumulation and phenotypes (M1 pro-inflammatory macrophage or M2 anti-inflammatory macrophage) were evaluated by immunohistological analysis and RT-PCR. Matrix metalloproteinase (MMP) activity levels were measured by gelatin zymography. The survival rate was significantly higher (81.1% vs. 48.2%, P<0.05), and the cardiac rupture rate was significantly lower in AIM‒/‒ mice than in WT mice (10.8% vs. 31.5%, P<0.05). The number of M1 macrophages and the expression levels of M1 markers (iNOS and IL-6) in the infarcted myocardium were significantly lower in AIM‒/‒ mice than in WT mice. In contrast, there was no difference in the number of M2 macrophages and the expression of M2 markers (Arg-1, CD206 and TGF-β1) between the two groups. The ratio of apoptotic macrophages in the total macrophages was significantly higher in AIM‒/‒ mice than in WT mice, although MCP-1 expression did not differ between the two groups. MMP-2 and 9 activity levels in the infarcted myocardium were significantly lower in AIM‒/‒ mice than in WT mice. CONCLUSIONS: These findings suggest that AIM depletion decreases the levels of M1 macrophages, which are a potent source of MMP-2 and 9, in the infarcted myocardium in the acute phase after MI by promoting macrophage apoptosis, and leads to a decrease in the incidence of cardiac rupture and improvements in survival rates. - Estimating Sample Size for a Feasibility Study of Computer-Assisted Input Support to EDC.
Naoki Nishimoto; Naomi Tamura; Jun Kunikata; Sumiko Akahori; Tomoaki Sogo; Yuma Tani; Hideto Yokoi
Studies in health technology and informatics, 245, 1279, 1279, 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, The aim of this study was to to estimate the sample size for the assumed feasibility study of the computer-assisted input support on a clinica trial. More than 1,500 observations were required for the feasibility study with assumed settings. Further study was required for more efficient research design. - 香川県における子育て支援プログラム導入の試み 「前向き子育てプログラム(トリプルP)」の有用性の検討
鈴木 裕美; 依田 健志; 西本 尚樹; 神田 かなえ; 平尾 智広
地域環境保健福祉研究, 19, 1, 25, 32, 香川環境保健福祉学会, Dec. 2016, [Peer-reviewed]
Japanese - 医療機器不具合用語集における同義語抽出に向けた異義語除外法の検討
谷川原 綾子; 西本 尚樹; 辻 真太朗; 福田 晋久; 谷川 琢海; 上杉 正人; 小笠原 克彦; 横井 英人
医療情報学連合大会論文集, 36回, 2, 1038, 1039, (一社)日本医療情報学会, Nov. 2016
Japanese - Estimating the Duration of Public Concern After the Fukushima Dai-ichi Nuclear Power Station Accident from the Occurrence of Radiation Exposure-Related Terms on Twitter: A Retrospective Data Analysis
Naoki Nishimoto; Mizuki Ota; Ayako Yagahara; Katsuhiko Ogasawara
JMIR Public Health and Surveillance, 2, 2, e168, {JMIR} Publications Inc., Nov. 2016, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: After the Fukushima Dai-ichi Nuclear Power Station accident in Japan on March 11, 2011, a large number of comments, both positive and negative, were posted on social media. OBJECTIVE: The objective of this study was to clarify the characteristics of the trend in the number of tweets posted on Twitter, and to estimate how long public concern regarding the accident continued. We surveyed the attenuation period of the first term occurrence related to radiation exposure as a surrogate endpoint for the duration of concern. METHODS: We retrieved 18,891,284 tweets from Twitter data between March 11, 2011 and March 10, 2012, containing 143 variables in Japanese. We selected radiation, radioactive, Sievert (Sv), Becquerel (Bq), and gray (Gy) as keywords to estimate the attenuation period of public concern regarding radiation exposure. These data, formatted as comma-separated values, were transferred into a Statistical Analysis System (SAS) dataset for analysis, and survival analysis methodology was followed using the SAS LIFETEST procedure. This study was approved by the institutional review board of Hokkaido University and informed consent was waived. RESULTS: A Kaplan-Meier curve was used to show the rate of Twitter users posting a message after the accident that included one or more of the keywords. The term Sv occurred in tweets up to one year after the first tweet. Among the Twitter users studied, 75.32% (880,108/1,168,542) tweeted the word radioactive and 9.20% (107,522/1,168,542) tweeted the term Sv. The first reduction was observed within the first 7 days after March 11, 2011. The means and standard errors (SEs) of the duration from the first tweet on March 11, 2011 were 31.9 days (SE 0.096) for radioactive and 300.6 days (SE 0.181) for Sv. These keywords were still being used at the end of the study period. The mean attenuation period for radioactive was one month, and approximately one year for radiation and radiation units. The difference in mean duration between the keywords was attributed to the effect of mass media. Regularly posted messages, such as daily radiation dose reports, were relatively easy to detect from their time and formatted contents. The survival estimation indicated that public concern about the nuclear power plant accident remained after one year. CONCLUSIONS: Although the simple plot of the number of tweets did not show clear results, we estimated the mean attenuation period as approximately one month for the keyword radioactive, and found that the keywords were still being used in posts at the end of the study period. Further research is required to quantify the effect of other phrases in social media data. The results of this exploratory study should advance progress in influencing and quantifying the communication of risk. - アルコール使用障害特定テスト(AUDIT)スコアは飲酒量の推定に有用である
藤井 英樹; 西本 尚樹; 宮野 正人; 上田 渉; 大庭 宏子; 山口 誓子; 青木 哲哉; 倉井 修; 河田 則文; 大川 清孝
日本アルコール・薬物医学会雑誌, 51, 5, 293, 301, (一社)日本アルコール・アディクション医学会, Oct. 2016, [Peer-reviewed]
Japanese, 世界保健機構(WHO)が開発した過剰飲酒を短時間で評価するための10項目の質問文からなる「アルコール使用障害特定テスト」(The Alcohol Use Disorders Identification Test;AUDIT)の、飲酒量の推定における有用性を検討することを目的に、2014年6月〜2015年3月に当院の内科外来に通院した患者334名(男性174名、女性160名)を対象に、飲酒量を正確に推定するため電子カルテ上に飲酒頻度(日、週、月)、種類(ビール、ワイン、ウイスキー等)、量(コップ、グラス等)から1日当たりの摂取エタノール量(g/日)を自動計算するテンプレート(Juso Alcohol Calculator;JAC)を作成し、これにより推定された飲酒量と、同じ患者にAUDITを施行して得られたスコアの相関を検討した。その結果、JACによる1日当たりの摂取エタノールとAUDITスコアの間に高い相関が認められた。また、10分割交差法を用いたhazardous drinking(飲酒者や他者に対する有害事象のリスクが上昇するアルコール摂取パターン、56名(16%)が該当)におけるAUDITスコアの至適カットオフ値は8.2点で、男性10.0点、女性6.1点と、男女差を認めた。 - The Alcohol Use Disorders. Identification Test (AUDIT) score is useful for predicting alcohol consumption.
Hideki Fujii; Naoki Nishimoto; Masato Miyano; Wataru Ueda; Hiroko Oba; Seiko Yamaguchi; Tetsuya Aoki; Osamu Kurai; Norifumi Kawada; Kiyotaka Okawa
Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence, 51, 5, 293, 301, Oct. 2016, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, It is important to screen for alcohol consumption and drinking customs by using a stan- dardized method. The aim of this study was to investigate whether standardized questionnaire was useful for predicting alcohol consumption. A cross-sectional study using the Alcohol Use Disorders Identification Test (AUDIT) was conducted in 334 outpatients who consulted the Internal Medicine Department of Osaka City Juso Hospital. The patients completed self-reported questionnaires and underwent a diagnostic interview, physical examination, and laboratory testing. Forty (23%) male patients reported daily alcohol consumption 40 g, and 16 (10%) female patients reported consumption 20 g. The optimal cutoff values of hazardous drinking (all patients)/ drinker (male)/ drinker (female) were calculated using a 10-fold cross validation, resulting in an optimal AUDIT score cutoff of 8.2/ 7.2/ 6.1, with sensitivity of 95.5%/ 96.3%/ 88.9%, specificity of 87.0%/ 96.3%/ 88.9%, false positive rate of 13.0%/ 9.4%/6.6%, false negative rate of 4.5%/ 3.'%/ 11.1%, and area under the receiver operating characteristic curve of 0.97/ 0.98/ 0.99. In conclusion, this study showed that the AUDIT score was useful for predicting alcohol consumption. - コンジョイント分析による診療放射線技師を対象とした就労環境の選好に関する調査 個人属性
北川 剛; 井上 剛; 藤原 健祐; 谷川原 綾子; 福田 普久; 西本 尚樹; 小笠原 克彦
日本放射線技術学会雑誌, 72, 9, 832, 832, (公社)日本放射線技術学会, Sep. 2016
Japanese - The Alcohol Use Disorders Identification Test for Consumption (AUDIT-C) is more useful than pre-existing laboratory tests for predicting hazardous drinking: a cross-sectional study.
Hideki Fujii; Naoki Nishimoto; Seiko Yamaguchi; Osamu Kurai; Masato Miyano; Wataru Ueda; Hiroko Oba; Tetsuya Aoki; Norifumi Kawada; Kiyotaka Okawa
BMC public health, 16, 379, 379, 10 May 2016, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: It is important to screen for alcohol consumption and drinking customs in a standardized manner. The aim of this study was 1) to investigate whether the AUDIT score is useful for predicting hazardous drinking using optimal cutoff scores and 2) to use multivariate analysis to evaluate whether the AUDIT score was more useful than pre-existing laboratory tests for predicting hazardous drinking. METHODS: A cross-sectional study using the Alcohol Use Disorders Identification Test (AUDIT) was conducted in 334 outpatients who consulted our internal medicine department. The patients completed self-reported questionnaires and underwent a diagnostic interview, physical examination, and laboratory testing. RESULTS: Forty (23 %) male patients reported daily alcohol consumption ≥ 40 g, and 16 (10 %) female patients reported consumption ≥ 20 g. The optimal cutoff values of hazardous drinking were calculated using a 10-fold cross validation, resulting in an optimal AUDIT score cutoff of 8.2, with a sensitivity of 95.5 %, specificity of 87.0 %, false positive rate of 13.0 %, false negative rate of 4.5 %, and area under the receiver operating characteristic curve of 0.97. Multivariate analysis revealed that the most popular short version of the AUDIT consisting solely of its three consumption items (AUDIT-C) and patient sex were significantly associated with hazardous drinking. The aspartate transaminase (AST)/alanine transaminase (ALT) ratio and mean corpuscular volume (MCV) were weakly significant. CONCLUSIONS: This study showed that the AUDIT score and particularly the AUDIT-C score were more useful than the AST/ALT ratio and MCV for predicting hazardous drinking. - Visualization of the X-ray Radiography Technical Process by Hierarchical Task Analysis
Yuki Yokooka; Ayako Yagahara; Shintaro Tsuji; Naoki Nishimoto; Masahito Uesugi; Yasuo Okuda; Katsuhiko Ogasawara
JOURNAL OF MEDICAL IMAGING AND HEALTH INFORMATICS, 6, 2, 532, 538, Apr. 2016, [Peer-reviewed]
English, Scientific journal - 放射線技術学に関する用語集の日本語表記と意味記述に関する比較
谷川原 綾子; 辻 真太朗; 福田 晋久; 西本 尚樹; 小笠原 克彦
日本放射線技術学会雑誌, 72, 3, 203, 208, (公社)日本放射線技術学会, Mar. 2016, [Peer-reviewed]
Japanese, 放射線技術学に関する用語集の日本語表記と意味記述について比較検討した。放射線技術学用語集(1994年)・放射線技術学用語集・補遺編(2003年)(JSRT用語集)、電子放射線診療用語集(JRS用語集)、医学物理学用語集(JSMP用語集)を用いた。JSRT用語集から5620表記、JRS用語集から6015表記、JSMP用語集から6829語、重複を除いて全14982語を抽出した。二つ以上の用語集で英語表記の一致が見られた用語は2735語(18.3%)、全ての用語集で一致した用語は801語(5.3%)であった。三つの用語集で英語表記が一致していた用語について、二つ以上の用語集で日本語表記が一致した用語は752語(93.9%)、二つ以上の用語集で英語表記が一致した用語では、1240語(64.1%)が日本語表記においても一致した。JSRT用語集、JRS用語集から英語表記が一致した1233語中、両方に意味が記述されていた用語は351語(28.5%)で、意味が異なった用語は8語あった。 - [Comparison of Japanese Notation and Meanings among Three Terminologies in Radiological Technology Domain].
Ayako Yagahara; Shintaro Tsuji; Akihisa Hukuda; Naoki Nishimoto; Katsuhiko Ogasawara
Nihon Hoshasen Gijutsu Gakkai zasshi, 72, 3, 203, 8, Mar. 2016, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, PURPOSE: The purpose of this study is to investigate the differences in the notation of technical terms and their meanings among three terminologies in Japanese radiology-related societies. MATERIALS AND METHODS: The three terminologies compared in this study were "radiological technology terminology" and its supplement published by the Japan Society of Radiological Technology, "medical physics terminology" published by the Japan Society of Medical Physics, and "electric radiation terminology" published by the Japan Radiological Society. Terms were entered into spreadsheets and classified into the following three categories: Japanese notation, English notation, and meanings. In the English notation, terms were matched to character strings in the three terminologies and were extracted and compared. The Japanese notations were compared among three terminologies, and the difference between the meanings of the two terminologies radiological technology terminology and electric radiation terminology were compared. RESULTS AND DISCUSSION: There were a total of 14,982 terms in the three terminologies. In English character strings, 2,735 terms were matched to more than two terminologies, with 801 of these terms matched to all the three terminologies. Of those terms in English character strings matched to three terminologies, 752 matched to Japanese character strings. Of the terms in English character strings matched to two terminologies, 1,240 matched to Japanese character strings. With regard to the meanings category, eight terms had mismatched meanings between the two terminologies. For these terms, there were common concepts between two different meaning terms, and it was considered that the derived concepts were described based on domain. - χ2値を用いた放射線技術学分野に関する特徴語抽出の試み
福田 晋久; 谷川原 綾子; 辻 真太朗; 西本 尚樹; 谷川 琢海; 小笠原 克彦
日本放射線技術学会総会学術大会予稿集, 72回, 231, 231, (公社)日本放射線技術学会, Feb. 2016
Japanese - 放射線技術学用語集と教科書の索引語の重複調査
辻 真太朗; 福田 晋久; 谷川原 綾子; 川眞田 実; 西本 尚樹; 小笠原 克彦
日本放射線技術学会総会学術大会予稿集, 72回, 231, 231, (公社)日本放射線技術学会, Feb. 2016
Japanese - Epidemiology of Multiple System Atrophy in Hokkaido, the Northernmost Island of Japan.
Ken Sakushima; Naoki Nishimoto; Masanori Nojima; Masaaki Matsushima; Ichiro Yabe; Norihiro Sato; Mitsuru Mori; Hidenao Sasaki
Cerebellum (London, England), 14, 6, 682, 7, Dec. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal, Multiple system atrophy (MSA) is an intractable neurodegenerative disorder that is characterized by various combinations of autonomic failure, cerebellar ataxia, and parkinsonism. We conducted an epidemiological study of MSA using the combined data of a national registry system and a postal survey in Hokkaido, Japan. A postal survey was conducted in 2013 based on national registry data from 2006 to 2011. This survey contained the current status of each patient with MSA that had been collected from attending physicians and recorded into a national registry. Survey items included date, outcomes, primary symptoms, and activities of daily living at the last medical examination. Confirmation data of the diagnosis by a board-certified neurologist was also collected. Based on the national registry data, 1,092 patients with MSA were selected as our target population. The response rate of the postal survey was 81% (885/1,092). After excluding inappropriate responses, 839 patients with MSA were analyzed. Forty-nine percent of the patients were male, and the mean onset age was 62.1 ± 10.4 years. A Kaplan-Meier survival curve revealed that patients with onset symptoms of cerebellar ataxia had a better prognosis than those with onset of parkinsonism or autonomic failure (p < 0.01). Additionally, we found that a higher onset age was associated with poor prognosis. We found that patients with cerebellar ataxia at onset had a better survival prognosis than those with parkinsonism or autonomic failure at onset and that patients with an older age at onset had a worse survival prognosis. - 医療機器不具合用語集の現状調査と問題点抽出
谷川原 綾子; 辻 真太朗; 福田 晋久; 西本 尚樹; 谷川 琢海; 上杉 正人; 小笠原 克彦; 横井 英人
医療情報学連合大会論文集, 35回, 846, 848, (一社)日本医療情報学会, Nov. 2015
Japanese - 美容医療機関ウェブサイトの医療広告・広報に関する調査研究 2012年と2014年のウェブサイトの比較検証
大場 久照; 広庭 歩佳; 谷川原 綾子; 西本 尚樹; 谷川 琢海
医療情報学連合大会論文集, 35回, 1240, 1242, (一社)日本医療情報学会, Nov. 2015
Japanese - 放射線関連Tweetの現状と印象度調査の試み
青木 智大; 谷 祐児; 谷川原 綾子; 西本 尚樹; 小笠原 克彦
北海道放射線技術雑誌, 79, 96, 96, (公社)日本放射線技術学会-北海道支部, Oct. 2015
Japanese - コンジョイント分析による診療放射線技師を対象とした就労環境の選好に関する調査
藤原 健祐; 谷川原 綾子; 北川 剛; 井上 剛; 福田 晋久; 西本 尚樹; 小笠原 克彦
北海道放射線技術雑誌, 79, 96, 96, (公社)日本放射線技術学会-北海道支部, Oct. 2015
Japanese - コンジョイント分析による診療放射線技師を対象とした就労環境の選好に関する調査
北川剛; 井上剛; 藤原健祐; 谷川原綾子; 福田普久; 西本尚樹; 小笠原克彦
日本放射線技術学会雑誌, 71, 9, 832, 833, 20 Sep. 2015, [Peer-reviewed]
Japanese - 近赤外分光法を用いた小児開心術における脳血流自動調節能の検討
干野 晃嗣; 西本 尚樹; 森本 裕二
麻酔, 64, 9, 960, 965, 克誠堂出版(株), Sep. 2015, [Peer-reviewed]
Japanese - 放射線技術分野への応用に向けたオントロジーの分類
福田 晋久; 辻 真太朗; 谷川原 綾子; 西本 尚樹; 小笠原 克彦
日本放射線技術学会雑誌, 71, 6, 505, 511, (公社)日本放射線技術学会, Jun. 2015, [Peer-reviewed]
Japanese - An analysis of existing terminology towards constructing ontology in the field of the radiological technology
Shintaro Tsuji; Akihisa Fukuda; Ayako Yagahara; Naoki Nishimoto; Katsumi Homma; Katsuhiko Ogasawara
Nihon Hōshasen Gijutsu Gakkai zasshi, 71, 3, 186, 193, 01 Mar. 2015
Japanese, Scientific journal - 放射線技術学領域における用語オントロジーの構築に向けた分析
辻 真太朗; 福田 晋久; 谷川原 綾子; 西本 尚樹; 本間 勝美; 小笠原 克彦
日本放射線技術学会雑誌, 71, 3, 186, 193, (公社)日本放射線技術学会, Mar. 2015
Japanese, 放射線技術学分野の用語オントロジーの構築の検討を進めるため、学会名鑑に記載されている臨床医学、心理・教育学、総合工学の学会群を対象に、用語集の構築の有無を確認すると共に、各領域の用語集の特徴を比較した。各学会の公式ウェブサイトを検索した結果、用語集を構築しているのは臨床医学167学会中20学会、心理・教育学104学会中4学会、総合工学40学会中7学会であった。臨床医学分野の用語集は、他の分野と比較して電子媒体を中心とした用語集の電子化が進んでおり、閲覧者がPDFファイルとして入手することができ、日本語に対する英語の訳も記載されていた。一方課題として、電子媒体の用語集は収録語の増加に伴い検索・閲覧方法に限界があり、継続的なメンテナンスも容易ではなく、今後はオントロジー技術を利用することが必要と考えられた。 - 臨床試験登録データベースを用いた試験件数増加の変化点検出
西本 尚樹; 伊藤 陽一; 谷川原 綾子; 辻 真太朗; 福田 晋久; 上杉 正人; 小笠原 克彦
医療情報学連合大会論文集, 34回, 306, 307, (一社)日本医療情報学会, Nov. 2014
Japanese - 放射線治療におけるエラーの分類に対する標準化を目指したオントロジーの適用
辻 真太朗; 福田 晋久; 谷川原 綾子; 西本 尚樹; 本間 勝美; 小笠原 克彦
日本放射線技術学会総会学術大会予稿集, 70回, 186, 186, (公社)日本放射線技術学会, Feb. 2014
Japanese - 共起行列を用いた放射線防護に関する文献情報の体系化の試み
福田 晋久; 辻 真太朗; 谷川原 綾子; 西本 尚樹; 本間 勝美; 小笠原 克彦
日本放射線技術学会総会学術大会予稿集, 70回, 186, 186, (公社)日本放射線技術学会, Feb. 2014
Japanese - Data Quality and Interpretation of Analysis Results
Nishimoto Naoki
Jpn. J. Radiol. Technol., 70, 2, 155, 162, Japanese Society of Radiological Technology, 2014
Japanese - Neonatal exposure to sevoflurane causes significant suppression of hippocampal long-term potentiation in postgrowth rats.
Rui Kato; Kaori Tachibana; Naoki Nishimoto; Toshikazu Hashimoto; Yosuke Uchida; Ryoko Ito; Kenkichi Tsuruga; Koichi Takita; Yuji Morimoto
Anesthesia and analgesia, 117, 6, 1429, 35, Dec. 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: The inhaled anesthetic sevoflurane is commonly used for neonates in the clinical setting. Recent studies have indicated that exposure of neonatal rodents to sevoflurane causes acute widespread neurodegeneration and long-lasting neurocognitive dysfunction. Although acute toxic effects of sevoflurane on cellular viability in the hippocampus have been reported in some studies, little is known about the effects of neonatal sevoflurane exposure on long-term hippocampal synaptic plasticity, which has been implicated in the processes of learning and memory formation. Our study is the first to examine the long-term electrophysiological impact of neonatal exposure to a clinically relevant concentration of sevoflurane. METHODS: On postnatal day 7, rats were exposed to sevoflurane (1% or 2% for 2 hours) with oxygen. To eliminate the influence of blood gas abnormalities caused by sevoflurane-induced respiratory suppression, a group of rats were exposed to a high concentration of carbon dioxide (8% for 2 hours) to duplicate respiratory disturbances caused by 2% sevoflurane exposure. RESULTS: Exposure of neonatal rats to 2% sevoflurane for 2 hours caused significant suppression of long-term potentiation (LTP) induction in the postgrowth period. There was no significant difference between the control group and the CO2-exposed group in LTP induction, indicating that sevoflurane-induced LTP suppression was not caused by blood gas abnormalities. CONCLUSION: Our present findings indicate that neonatal exposure to sevoflurane at a higher concentration can cause alterations in the hippocampal synaptic plasticity that persists into adulthood. - 臨床試験登録データベースを用いた試験情報の探索的解析
西本 尚樹; 伊藤 陽一; 谷川原 綾子; 辻 真太朗; 福田 晋久; 小笠原 克彦
医療情報学連合大会論文集, 33回, 402, 403, (一社)日本医療情報学会, Nov. 2013
Japanese - Reduced-Intensity Versus Myeloablative Conditioning Allogeneic Hematopoietic Stem Cell Transplantation for Patients Aged Over 45 Years with Acute Lymphoblastic Leukemia (ALL) in Remission: A Study From the ALL Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT).
Bone Marrow Transplantation 48, Nov. 2013, [Peer-reviewed] - 医学・医療分野におけるオントロジーに関する文献の調査
福田 晋久; 辻 真太朗; 谷川原 綾子; 西本 尚樹; 本間 勝美; 上杉 正人; 小笠原 克彦
日本放射線技術学会総会学術大会予稿集, 69回, 151, 151, (公社)日本放射線技術学会, Feb. 2013
Japanese - 放射線技術領域における非劣性検定の症例数設計
西本 尚樹; 伊藤 陽一; 谷川原 綾子; 辻 真太朗; 福田 晋久; 谷川 琢海; 小笠原 克彦
日本放射線技術学会総会学術大会予稿集, 69回, 156, 156, (公社)日本放射線技術学会, Feb. 2013
Japanese - 12. Sample Size Determination in Radiologic Technology Research
Tani Yuji
Jpn. J. Radiol. Technol., 69, 12, 1436, 1443, Japanese Society of Radiological Technology, 2013
Japanese - An ontology design for visualizing implicit knowledge of the radiotherapy risk.
Shintaro Tsuji; Akihisa Fukuda; Ayako Yagahara; Katsumi Homma; Naoki Nishimoto; Masahito Uesugi; Katsuhiko Ogasawara
Studies in health technology and informatics, 192, 994, 994, 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal, Knowledge sharing of radiotherapy risk contributes to keep the safety practice between the oncologists, medical physicists, and therapists. But the mechanisms of risks tend to complex because of its diversities. Recently, an ontological analysis is tried to share knowledge in the various domains. Therefore, the aim of this study is to construct Radiotherapy Risk Ontology (RRO) and clarify the implicit structures of risks towards knowledge sharing. The method of this study is below. First, the classes and relations were extracted from the risk categorization of the publications. Second, these classes and relationships were connecting and mapping by the ontology editor. Third, the total relationships of classes were verified using paired comparison chart. This paper distinguishes between publication-oriented relationships and the other relationships. And these relationships was defined the explicit and implicit relationships. RRO was constructed 789 classes and 14 types of the explicit relationships. The 22 types of the implicit relationships were clarified using paired comparison. RRO provided the conceptual mapping and the implicit knowledge. The result of this study assisted the knowledge sharing. - Constructing Mammography Examination Process Ontology Using Affinity Diagram and Hierarchical Task Analysis
Ayako Yagahara; Shintarou Tsuji; Akihisa Fukuda; Yuki Yokooka; Naoki Nishimoto; Kunio Kurowarabi; Katsuhiko Ogasawara
MEDINFO 2013: PROCEEDINGS OF THE 14TH WORLD CONGRESS ON MEDICAL AND HEALTH INFORMATICS, PTS 1 AND 2, 192, 1059, 1059, 2013, [Peer-reviewed], [International Magazine]
English, International conference proceedings - 生物統計学語彙の構造化を目指した用語収集システムの構築と語彙の階層化
西本 尚樹; 伊藤 陽一; 谷川原 綾子; 横岡 由姫; 辻 真太朗; 福田 晋久; 上杉 正人; 小笠原 克彦
医療情報学連合大会論文集, 32回, 274, 275, (一社)日本医療情報学会, Nov. 2012
Japanese - マンモグラフィ内外斜位方向撮影技術に関するオントロジー構築
谷川原 綾子; 横岡 由姫; 辻 真太朗; 福田 晋久; 西本 尚樹; 黒蕨 邦夫; 小笠原 克彦
医療情報学連合大会論文集, 32回, 1454, 1455, (一社)日本医療情報学会, Nov. 2012
Japanese - オントロジーに関する英文論文抄録を対象とした使用目的の分類
福田 晋久; 辻 真太朗; 谷川原 綾子; 西本 尚樹; 上杉 正人; 小笠原 克彦
医療情報学連合大会論文集, 32回, 1456, 1457, (一社)日本医療情報学会, Nov. 2012
Japanese - ロジック・ツリーを用いた情報共有のための電子カルテ機能の可視化
横岡 由姫; 谷川原 綾子; 辻 真太朗; 向井 まさみ; 西本 尚樹; 上杉 正人; 奥田 保男; 小笠原 克彦
医療情報学連合大会論文集, 32回, 1462, 1463, (一社)日本医療情報学会, Nov. 2012
Japanese - 自主臨床研究における予定症例登録数未達の原因に関する関係者へのインタビュー調査
堀江 奈穂; 佐久嶋 研; 大庭 幸治; 西本 尚樹; 伊藤 陽一; 佐藤 典宏
臨床薬理, 43, Suppl., S265, S265, (一社)日本臨床薬理学会, Oct. 2012
Japanese - 形態素解析を用いたオントロジーに関する文献の調査
福田 晋久; 辻 真太朗; 横岡 由姫; 谷川原 綾子; 西本 尚樹; 上杉 正人; 小笠原 克彦
日本放射線技術学会総会学術大会予稿集, 68回, 129, 129, (公社)日本放射線技術学会, Feb. 2012
Japanese - アソシエーション分析を用いた放射線治療計画の確認タスクに対する暗黙的ルールの抽出
辻 真太朗; 福田 晋久; 谷川原 綾子; 西本 尚樹; 上杉 正人; 小笠原 克彦
日本放射線技術学会総会学術大会予稿集, 68回, 134, 134, (公社)日本放射線技術学会, Feb. 2012
Japanese - 放射線技術学研究における統計解析手法の集計と誤用対策の提案
西本 尚樹; 伊藤 陽一; 江口 菜弥帆; 谷川原 綾子; 上杉 正人; 小笠原 克彦
日本放射線技術学会総会学術大会予稿集, 68回, 279, 279, (公社)日本放射線技術学会, Feb. 2012
Japanese - Development of terminology for mammographic techniques for radiological technologists.
Ayako Yagahara; Yuki Yokooka; Shintaro Tsuji; Naoki Nishimoto; Masahito Uesugi; Hiroshi Muto; Hisateru Ohba; Kunio Kurowarabi; Katsuhiko Ogasawara
Radiological physics and technology, 4, 2, 121, 7, Jul. 2011, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, We are developing a mammographic ontology to share knowledge of the mammographic domain for radiologic technologists, with the aim of improving mammographic techniques. As a first step in constructing the ontology, we used mammography reference books to establish mammographic terminology for identifying currently available knowledge. This study proceeded in three steps: (1) determination of the domain and scope of the terminology, (2) lexical extraction, and (3) construction of hierarchical structures. We extracted terms mainly from three reference books and constructed the hierarchical structures manually. We compared features of the terms extracted from the three reference books. We constructed a terminology consisting of 440 subclasses grouped into 19 top-level classes: anatomic entity, image quality factor, findings, material, risk, breast, histological classification of breast tumors, role, foreign body, mammographic technique, physics, purpose of mammography examination, explanation of mammography examination, image development, abbreviation, quality control, equipment, interpretation, and evaluation of clinical imaging. The number of terms that occurred in the subclasses varied depending on which reference book was used. We developed a terminology of mammographic techniques for radiologic technologists consisting of 440 terms. - 放射線技術分野における検査オントロジー利用の可能性の検討 文献から調査した応用例
福田 晋久; 辻 真太朗; 横岡 由姫; 谷川原 綾子; 西本 尚樹; 上杉 正人; 小笠原 克彦
日本放射線技術学会総会学術大会予稿集, 67回, 157, 157, (公社)日本放射線技術学会, Feb. 2011
Japanese - 放射線技術分野において検査オントロジーは何に使えるのか? 現場からのニーズの調査
辻 真太朗; 福田 晋久; 横岡 由姫; 谷川原 綾子; 西本 尚樹; 上杉 正人; 小笠原 克彦
日本放射線技術学会総会学術大会予稿集, 67回, 157, 157, (公社)日本放射線技術学会, Feb. 2011
Japanese - 放射線治療計画の確認モデルの構築とルールの定義の試み
辻 真太朗; 福田 晋久; 横岡 由姫; 谷川原 綾子; 西本 尚樹; 上杉 正人; 小笠原 克彦
日本放射線技術学会総会学術大会予稿集, 67回, 157, 158, (公社)日本放射線技術学会, Feb. 2011
Japanese - 放射線医学・技術学用語集の比較 用語の和訳と意味の記述について
谷川原 綾子; 横岡 由姫; 辻 真太朗; 西本 尚樹; 上杉 正人; 小笠原 克彦
日本放射線技術学会総会学術大会予稿集, 67回, 158, 159, (公社)日本放射線技術学会, Feb. 2011
Japanese - X線撮影検査オントロジーのためのAnalytic Hierarchy Processを用いた診断可否の判断の明示化
横岡 由姫; 谷川原 綾子; 辻 真太朗; 上杉 正人; 西本 尚樹; 小笠原 克彦
日本放射線技術学会総会学術大会予稿集, 67回, 230, 230, (公社)日本放射線技術学会, Feb. 2011
Japanese - Survey of patient and physician satisfaction regarding patient-centered outpatient consultations in Japan.
Kengo Kisa; Hidenobu Kawabata; Takamasa Itou; Naoki Nishimoto; Masaji Maezawa
Internal medicine (Tokyo, Japan), 50, 13, 1403, 8, 2011, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, OBJECTIVE: The purpose of this study was to show the difference in consultation satisfaction between patient and physician in rural settings, and identify the variables affecting their satisfaction regarding these encounters. METHODS: We collected data by administering questionnaires that included questions regarding satisfaction for a patient-centered approach to patients and physicians, transcribing data from medical records, and observing consultations in person. We then modeled cumulative logits of patient and physician satisfaction scores by performing ordered logistic regression using the proportional odds model. PATIENTS: Seven physicians and 122 patients participated in the study. RESULTS: Both patients and physicians expressed high satisfaction with their consultation sessions. Patient satisfaction tended to be higher than physician satisfaction. Physicians were satisfied with longer consultations but patients were not. Moreover, the long waiting times dissatisfied patients. In cases of multiple healthcare episodes (courses of treatment for a different condition) during a single visit, patient satisfaction decreased, while physician satisfaction increased. Physician satisfaction for interactions in general was less when they checked the same patient who had previously visited them. CONCLUSION: Our findings suggest that if physicians feel satisfied with their consultation, patients also feel satisfied regardless of the physician's opinion. The variables that affect patient and physician satisfaction include prior visits with the same physician, consultation length, longer waiting times, and number of episodes. These findings from Japanese clinics are consistent with those previously reported for other countries. - Quantitative evaluation of expression difference in report assignments between nursing and radiologic technology departments.
Naoki Nishimoto; Yuki Yokooka; Ayako Yagahara; Masahito Uesugi; Katsuhiko Ogasawara
Radiological physics and technology, 4, 1, 29, 36, 2011, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Our purpose in this study was to investigate the expression differences in report assignments between students in nursing and radiologic technology departments. We have known that faculties could identify differences, such as word usage, through grading their students' assignments. However, there are no reports in the literature dealing with expression differences in vocabulary usage in medical informatics education based on statistical techniques or other quantitative measures. The report assignment asked for students' opinions in the event that they found a rare case of a disease in a hospital after they graduated from professional school. We processed student report data automatically, and we applied the space vector model and TF/IDF (term frequency/inverse document frequency) scoring to 129 report assignments. The similarity-score distributions among the assignments for these two departments were close to normal. We focused on the sets of terms that occurred exclusively in either department. For terms such as "radiation therapy" or "communication skills" that occurred in the radiologic technology department, the TF/IDF score was 8.01. The same score was obtained for terms such as "privacy guidelines" or "consent of patients" that occurred in the nursing department. These results will help faculties to provide a better education based on identified expression differences from students' background knowledge. - マンモグラフィMLO撮影におけるポジショニングのプロセス分析とマンモグラムに与える影響
谷川原 綾子; 横岡 由姫; 辻 真太朗; 西本 尚樹; 上杉 正人; 黒蕨 邦夫; 小笠原 克彦
医療情報学連合大会論文集, 30回, 1330, 1331, (一社)日本医療情報学会, Nov. 2010
Japanese - 診療放射線技師の意思決定に影響を与える概念の抽出 検査オントロジーによる概念関係の可視化
辻 真太朗; 横岡 由姫; 谷川原 綾子; 上杉 正人; 西本 尚樹; 小笠原 克彦
日本放射線技術学会総会学術大会予稿集, 66回, 235, 235, (公社)日本放射線技術学会, Feb. 2010
Japanese - 整形領域撮影時における再撮影タスク分析とX線検査オントロジーの構築
横岡 由姫; 谷川原 綾子; 辻 真太朗; 西本 尚樹; 上杉 正人; 寺下 貴美; 小笠原 克彦
日本放射線技術学会総会学術大会予稿集, 66回, 239, 240, (公社)日本放射線技術学会, Feb. 2010
Japanese - Quantitative analysis of ontology research articles in the radiologic domain.
Naoki Nishimoto; Ayako Yagahara; Yuki Yokooka; Shintaro Tsuji; Masahito Uesugi; Katsuhiko Ogasawara; Masaji Maezawa
Radiological physics and technology, 3, 2, 171, 177, 2010, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, To investigate the most advanced ontology research in health care and its impact on the radiologic domain, we proposed a concept identification and abstraction technique called "Concept Step". This technique identifies a MeSH term, medical subject headings used in PubMed, in a sentence and climbs up through its hierarchy to reach an abstract concept. We developed original Java software to implement this technique. We tested it on 2,774 abstracts in health-care ontology research retrieved from MEDLINE on 23 October 2008. The total number of MeSH terms was 112,690. We counted a total of 33 MeSH terms (0.029%) in the radiologic domain. The most frequently occurring term was "radiology", which occurred 21 times in the article set. Other frequent terms were "magnetic resonance imaging" and "tomography", the counts of which were 4 and 3, respectively. A pair plot showed no correlation among the MeSH categories "Analytical Diagnostic and Therapeutic Techniques and Equipment", "Anatomy", "Biological Sciences", and "Chemicals and Drugs". We conclude that ontology research is well established in the biomedical domain, and that further study is required in the radiologic domain. - タスクオントロジーによるX線撮影技術プロセスの可視化の試み トラブルの有無による撮影プロセスの変化分析
横岡 由姫; 谷川原 綾子; 辻 真太朗; 上杉 正人; 西本 尚樹; 寺下 貴美; 小笠原 克彦; 清野 孝
医療情報学連合大会論文集, 29回, 1042, 1043, (一社)日本医療情報学会, Nov. 2009
Japanese - マンモグラフィ撮影装置を対象とした品質管理オントロジーの構築
谷川原 綾子; 横岡 由姫; 辻 真太朗; 西本 尚樹; 上杉 正人; 黒蕨 邦夫; 寺下 貴美; 小笠原 克彦
医療情報学連合大会論文集, 29回, 1046, 1047, (一社)日本医療情報学会, Nov. 2009
Japanese - Interpretive Structural Modeling(ISM)法による乳房撮影技術の構造化
工藤 希美; 黒蕨 邦夫; 寺下 貴美; 西本 尚樹; 小笠原 克彦
日本放射線技術学会雑誌, 65, 10, 1385, 1390, (公社)日本放射線技術学会, Oct. 2009, [Peer-reviewed]
Japanese, 乳房撮影に関する撮影技術の要点を明確化し、複雑な撮影をより分かりやすく理解するため、Interpretive Structural Modeling(ISM)により乳房撮影技術の構造化を試みた。乳房撮影に関する経験・知識を有する診療放射線技師3例を対象とした。KJ法によりプラスの要因として13要因、マイナスの要因として1要因を抽出した。プラスの要因として、「経験(撮影回数)」「装置」「撮影条件」「解剖」「画像の確認」「講習会」「検査全体の説明」「圧迫動作に対する説明」「緊張を解くための説明(リラックス)」「撮影手技:圧迫動作」「撮影手技:立ち位置」「撮影手技:ミラーイメージ(左右の対称性)」「撮影手技:適切な大胸筋の角度に合わせる」であり、マイナスの要因としては「男性技師」が挙げられた。ISM法を用いて構造化を行い、乳房撮影技術は「検査全体の説明」を上位概念とする6層構造となった。 - Dual Snakesによるノイズ画像からの輪郭抽出と精度評価
谷川原 綾子; 西本 尚樹; 上杉 正人; 小笠原 克彦
医療情報学連合大会論文集, 28回, 444, 445, (一社)日本医療情報学会, Nov. 2008
Japanese - Parsing error correction of medical phrases for semantic annotation of clinical radiology reports.
Nishimoto N; Terae S; Uesugi M; Tanikawa T; Endou A; Ogasawara K; Sakurai T
AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium, 1070, 1070, Nov. 2008, [Peer-reviewed], [International Magazine]
English, Scientific journal, The purpose of this study is to develop a module for correcting errors in the product of a natural language parser. When tested with 300 CT reports, a total of 604 patterns were generated. The recall and precision was improved to 90.7% and 74.1% after processed by the module from initial 80.5% and 42.8% respectively. This rule-based module will help health care personnel reduce the cost of manual tagging correction for corpus building. - Development of a Medical-text Parsing Algorithm Based on Character Adjacent Probability Distribution for Japanese Radiology Reports
N. Nishimoto; S. Terae; M. Uesugi; K. Ogasawara; T. Sakurai
METHODS OF INFORMATION IN MEDICINE, 47, 6, 513, 521, 2008, [Peer-reviewed]
English, Scientific journal - 医療用語抽出のための用語分割点の探索
上杉 正人; 西本 尚樹; 谷川 琢海; 大場 久照; 寺下 貴美; 遠藤 晃; 小笠原 克彦; 櫻井 恒太郎
医療情報学連合大会論文集, 27回, 692, 693, (一社)日本医療情報学会, Nov. 2007
Japanese - Evaluation of Time Study Analysis by Segment Time Series Analysis using Maximum Entropy Method
TERASHITA T; SATOH H; ENDOH A; ISHII H; UESUGI M; NISHIMOTO N; TANIKAWA T; SON Q; OGASAWARA K; SAKURAI T
Japan Journal of Medical Informatics, 27, 3, 289, 296, Japan Association for Medical Informatics, 28 Sep. 2007, [Peer-reviewed]
Japanese, In our previous study, we applied frequency analysis on the sequential time study data of nurses in a busy in-patient ward, in order to extract periodic feature of the nursing service. In this paper, we prepared and analyzed a pair of simulated data of time study, in which either continuous or fragmented work schedule are assigned. Comparison of these simulated data with a pair of actual data, taken before and after the change of work schedule, was performed to examine whether the effect of the schedule change could be recognized and evaluated by the analysis. The simulated data was generated based on the total amount of classified items observed in the actual time study. The segment time series analysis was performed at the range of segment time series of 24hours and the shift of segment time of one hour for two days. The maximum entropy method (MEM) was used to calculate the power spectrum. The result of segment time series analysis of the simulated data featured a short cycle area and a medium to long cycle area. In the short cycle area, detailed variation of the cycle was clearly recognized, while the long term trend appeared in the medium to long cycle area. It is expected that the analysis of simulated data provides the visual assessment of the change of cycles of nursing service when applied to the data of actual time studies before and after the change of work schedule, as reported in our previous work. The simulation data analysis may be applied to evaluate the effect of other causes of interest. - 地域医療システム 患者フローと施設配置 北海道における小児救急医療機関の配置分析
谷川 琢海; 大場 久照; 上杉 正人; 寺下 貴美; 西本 尚樹; 小笠原 克彦; 櫻井 恒太郎
医療情報学連合大会論文集, 26回, 36, 38, (一社)日本医療情報学会, Oct. 2006
Japanese, 北海道における小児急病センターの数と配置について検討するため、患者の移動距離に着目したモデルの構築とGIS(地理情報システム)を利用した医療機関の適正配置について分析した。ミニ・サム型施設配置モデルと、ミニ・マックス型施設配置モデルの2つの手法を適用して患者の最大移動距離を最小化するような施設の配置と、各施設が受け持つ圏域を求めた。ミニ・サム型施設配置モデルを適用し、配置する施設の数を増加させると平均移動距離、最大移動距離はともに単調減少した。ミニ・マックス型施設配置モデルを適用し、施設の数を増加させると最大移動距離は連続的に単調減少し、施設の数を6としたときに165km、その後施設の数を増やすと施設の数が18のときに100kmを下回り、施設の数が21のときに91kmとなった。 - 地域医療システム 患者フローと施設配置 地理情報システム(GIS)を用いた北海道における二次医療圏の圏域分析
大場 久照; 小笠原 克彦; 谷川 琢海; 西本 尚樹; 遠藤 晃; 櫻井 恒太郎
医療情報学連合大会論文集, 26回, 47, 48, (一社)日本医療情報学会, Oct. 2006
Japanese, 地理情報システム(GIS)を用いて受療動向、通勤通学動向、買物動向の分析を行い、北海道における現在の21二次医療圏の圏域を検証し、新たな二次医療圏を提案した。二次医療圏別およびに入院・外来別に算出したPIより、現在の二次医療圏で医療が完結していない市町村の大部分は圏域境界に位置した。7二次医療圏の7町2村で二次医療圏の見直しが必要とされ、新しい二次医療圏を提案した。 - 小児救急病院を選択するための評価項目の優先度に関する分析 階層分析法を用いた保護者へのアンケート調査
谷川 琢海; 小笠原 克彦; 大場 久照; 上杉 正人; 西本 尚樹; 寺下 貴美; 遠藤 晃; 櫻井 恒太郎
医療情報学連合大会論文集, 26回, 325, 326, (一社)日本医療情報学会, Oct. 2006
Japanese, 地域住民の視点から、小児の救急医療体制において重要となる評価基準を明らかにすることを目的として、階層分析法により分析した。調査は2006年1,2月に、岩見沢市の四つの幼稚園に通う3歳から5歳迄の子供のいる保護者を対象とし、調査票を配布して行った。上位2階層(総合目的と評価基準)に着目して分析を行い、総合目的は「子供が急病の時の医療機関の選択」とした。評価基準は予備調査などから七つを選択した。有効回答数は73であった。各評価基準の重要度を比較したところ、「小児科の医師がいること」が全体の4割を占め、比較的大きかった他の評価基準「病院の評判が良い」「以前に受診したことがある」を4倍以上引き離していた。保護者は小児科専門医の診療を望んでおり、小児科医の存在が保護者の安心につながっていると考えられた。 - 看護業務タイムスタディのセグメント時系列解析 業務改善の効果の3次元スペクトルアレイによる視覚化
寺下 貴美; 佐藤 ひとみ; 遠藤 晃; 石井 英樹; 高橋 久美子; 孫 芹先; 谷川 琢海; 西本 尚樹; 上杉 正人; 小笠原 克彦; 櫻井 恒太郎
医療情報学連合大会論文集, 26回, 414, 417, (一社)日本医療情報学会, Oct. 2006
Japanese, タイムスタディで得られたデータを人員と時間毎に配置し、業務グループ毎に色分けして視覚的に分かりやすく表示する業務分布図を開発した。更に、最大エントロピー法を用いた周波数解析を行い、業務に内在する周期的特徴を明らかにしたが、業務の基点を表している位相の情報を抽出できなかった。そこで、位相の情報を明らかにするため、変動する周期的特徴の推移を抽出できるセグメント時系列解析を加えた分析を行い、業務改善の前後の相違を評価できるか検討した。その結果、タイムスタディの時系列解析によって周期的特徴の時間的推移を抽出でき、三次元スペクトルアレイで視覚化することで容易に認識できた。この手法を用いて業務改善の前後で周期的特徴の変化を比較し、新たなタイムスタディの評価が可能と思われた。 - Latent Semantic Analysisによる病名の類似度計測循環器病名と消化器病名の分離
上杉 正人; 小笠原 克彦; 西本 尚樹; 谷川 琢海; 寺下 貴美; 櫻井 恒太郎
医療情報学連合大会論文集, 26回, 542, 543, (一社)日本医療情報学会, Oct. 2006
Japanese, 病名を含む医療用語が複合語であることに注目し、潜在的意味解析(latant semantic analysis:LSA)の手法を用いて、病名とその文字の共起性から類似関係を調べ、分離・分類することを試みた。医療用語の意味の近さを定量評価する実験のためには、雑誌「循環器科」の抄録のタイトルから循環器病名の61語を取り出し対象とし、雑誌「日本消化器外科学会雑誌」の抄録のタイトルから消化器病名の82語を取り出し対象とした。そし病名と分解した文字を行と列にして共起性関係を行列にし、LSAを実施して病名群のベクトルから各病名に最も近い意味の病名を計算した。全体で127語(88.8%)がLSAにより正しく消化器病名群と循環器病名群に分離することができた。 - 医療文書から医療用語の分離抽出 単語長をパラメータとした新聞社説との相互比較
上杉 正人; 小笠原 克彦; 西本 尚樹; 谷川 琢海; 寺下 貴美; 櫻井 恒太郎
医療情報学連合大会論文集, 26回, 820, 821, (一社)日本医療情報学会, Oct. 2006
Japanese, 計算機システムに蓄積された医療データの再利用は医療の質の向上につながると考え、医療用語の分離抽出方法について検討した。1000例の症例報告と3年分及び16年分の新聞社説より2文字以上の漢字及びその前後のカタカナ文字列から成る対象単語群を抽出し、その中から医療用語を抽出した。その結果、症例報告では抽出した医療単語は77.3%で、社説を3年分から16年分に増やしたところ、各々の抽出精度は84.3%及び85.9%と改善が認められた。一方で、再現率は3年分の社説が98.4%、16年分の社説が95.8%と低下が認められた。単語長の長さが増えると共に医療用語の割合が増加したが、16語以上になると、低下する傾向にあった。医療用語中に不必要な漢字の負荷を認めた単語は約2割であった。今後、カタカナのみならず、ひらがなや英文字を含めた抽出を試みる必要がある。 - 日本と中国における病院情報システム導入実績の比較
孫 芹先; 蒋 国謙; 西本 尚樹; 谷川 琢海; 佐藤 ひとみ; 寺下 貴美; 頼 伏虎; 遠藤 晃; 櫻井 恒太郎
医療情報学連合大会論文集, 26回, 904, 907, (一社)日本医療情報学会, Oct. 2006
Japanese, 病院医療情報システムの導入状況を日本と中国の間で比較するため、両国の医療機関に対してアンケート調査を実施した。対象は両国の500床以上の総合病院、各200施設で、2006年4〜6月に各施設の医療情報責任者にあてて自記式調査表を2回に分けて郵送した。調査内容は、病院情報システム(システム)の代表的機能、システム導入による影響、及びコンピュータ化する代表的な機能の3点、各10項目で、得られた回答を分析した。その結果、日本のシステムのうち、初期の医事会計機能の導入は中国より約20年早いことがわかった。その他の機能は日本では長い時間をかけて普及してきたが、中国では最近の10年間で急速に普及した。また、中国の病院情報責任者はシステム導入の効果を日本より高く評価していた。 - Retrieving Issue of Identifying Semantic Relation between Atomic Medical Terms in Noun-noun Compounds in Reports of Computerized Tomography
NISHIMOTO N; TERAE S; JIANG G; UESUGI M; TERASHITA T; TANIKAWA T; ENDOU A; OGASAWARA K; SAKURAI T
Japan Journal of Medical Informatics, 25, 6, 413, 420, Japan Association for Medical Informatics, 20 Jun. 2006, [Peer-reviewed]
Japanese, Background: For the automatic retrieval of medical terms from clinical documents, the problems still remain in processing the noun-noun compounds. In addition, the semantic relations extracted from the compounds are useful for building the ontologies in the domain. Purpose: The purpose of the study is to investigate the distribution of the semantic relations between the two atomic medical terms of the noun-noun compounds extracted from the clinical documents. Methods: 100 clinical reports for CT examination generated in July 2005 were collected in a random way at Hokkaido University Hospital. The medical noun-noun compounds were extracted from the reports. We indexed the UMLS semantic type, group for each atomic medical term in the compounds, extracted the UMLS semantic relation according to the index, and analyzed the distribution of the semantic relations. Results: Only 29.9% of the compounds had the UMLS semantic relation defined (mainly including "location_of" and "adjacent_to"), and 70.1% of them undefined. Conclusion: The semantic relations defined in the UMLS are not enough for the noun-noun compounds extracted from the clinical reports, indicating further efforts are needed. - Semantic distribution study of noun*noun compounds in the Japanese CT clinical reports.
Nishimoto N; Satoshi T; Jiang G; Uesugi M; Terashita T; Tanikawa T; Endou A; Ogasawara K; Sakurai T
AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium, 1048, 1048, 2006, [Peer-reviewed], [International Magazine]
English, Scientific journal, The purpose of this study is to investigate the distribution of the semantic relationships between the two atomic medical terms of the noun-noun compounds extracted from the clinical documents in Japanese. Only 29.9% of the compounds had the UMLS semantic relation defined (mainly including "location_of" and "adjacent_to"). The results indicated that the semantic relations defined in the UMLS semantic network are not enough for describing the noun-noun medical compounds extracted from the Japanese clinical reports. - 看護業務タイムスタディーにおける最大エントロピー法を用いた時系列分析
寺下 貴美; 佐藤 ひとみ; 遠藤 晃; 高橋 久美子; 孫 芹先; 谷川 琢海; 西本 尚樹; 上杉 正人; 小笠原 克彦; 櫻井 恆太郎
医療情報学連合大会論文集, 25回, 404, 407, (一社)日本医療情報学会, Nov. 2005
Japanese - ミニ・マックス型モデルを用いた救急医療機関の適正配置 北海道の小児急病センターを事例としたモデルの構築と分析
谷川 琢海; 上杉 正人; 小笠原 克彦; 大場 久照; 寺下 貴美; 西本 尚樹; 櫻井 恒太郎
医療情報学連合大会論文集, 25回, 788, 789, (一社)日本医療情報学会, Nov. 2005
Japanese - 画像診断領域の論文抄録に含まれる複合語の意味的分布の調査
西本 尚樹; 蒋 国謙; 寺下 貴美; 上杉 正人; 谷川 琢海; 小笠原 克彦; 櫻井 恒太郎
医療情報学連合大会論文集, 25回, 970, 971, (一社)日本医療情報学会, Nov. 2005
Japanese - ラフ集合によるインシデントレポートからのインシデント発生要因の分析
小笠原 克彦; 寺下 貴美; 西本 尚樹; 谷川 琢海; 上杉 正人; 大場 久照; 佐藤 ひとみ; 蒋 国謙; 遠藤 晃; 櫻井 恒太郎
医療情報学連合大会論文集, 25回, 1106, 1107, (一社)日本医療情報学会, Nov. 2005
Japanese - 移動選択指数を用いた患者移動の地域的選択性 北海道を例として
大場 久照; 小笠原 克彦; 谷川 琢海; 西本 尚樹; 蒋 国謙; 遠藤 晃; 櫻井 恒太郎
医療情報学連合大会論文集, 24回, 494, 495, (一社)日本医療情報学会, Nov. 2004
Japanese - 最短路解析モデルを用いた小児急病センターの適正配置 北海道を事例としたモデルの構築と分析
谷川 琢海; 寺下 貴美; 小笠原 克彦; 大場 久照; 西本 尚樹; 櫻井 恒太郎
医療情報学連合大会論文集, 24回, 500, 501, (一社)日本医療情報学会, Nov. 2004
Japanese - 標準病名辞書による画像診断用語の形態素解析
西本 尚樹; 谷川 琢海; 蒋 国謙; 小笠原 克彦; 櫻井 恒太郎
医療情報学連合大会論文集, 24回, 812, 813, (一社)日本医療情報学会, Nov. 2004
Japanese - DEA法によるCT・MRIの分布の非効率性に関する検討 2次医療圏を対象として
小笠原 克彦; 大場 久照; 谷川 琢海; 西本 尚樹; 櫻井 恒太郎
医療情報学連合大会論文集, 24回, 1162, 1163, (一社)日本医療情報学会, Nov. 2004
Japanese - Gastric Phantom for Training Beginners in Gastric Segment (Stomap) Recognition (Clinical Technology)
NISHIMOTO NAOKI; HORITA KENJI; HOSOI TOMOHIRO; OGASAWARA KATSUHIKO
Japanese Journal of Radiological Technology, 59, 10, 1303, 1308, Japanese Society of Radiological Technology (JSRT), 20 Oct. 2003, [Peer-reviewed]
Japanese, It is usually difficult for a beginner to understand precisely and quickly the three-dimensional (3D) construction of gastric lesions in a gastric X-ray examination with barium meal. In this study, a training-use stomach phantom was developed using the stomach segment to provide beginners with an understanding of 3D stomach construction. The hook-shaped phantom (the shape of the stomach when a patient is in the supine position) was formed by using styrene, wire, and clay. It was then coated with dental stiffening agent, and wires were attached along the stomach segment. After drying, the st...
- 多系統萎縮症における侵襲的治療介入の傾向とリスク因子の解析
市之川萌奈美; 松島理明; 佐久嶋研; 金谷泰宏; 西本尚樹; 澤田潤; 松岡健; 上杉春雄; 南尚哉; 佐光一也; 武井麻子; 久原真; 玉腰暁子; 佐藤典宏; 矢部一郎, 日本神経学会学術大会プログラム・抄録集, 66th, 2025 - 北海道における多系統萎縮症レジストリ研究:HoRC-MSA2014-2024
松島理明; 足澤萌奈美; 工藤彰彦; 佐久嶋研; 金谷泰宏; 西本尚樹; 澤田潤; 松岡健; 上杉春雄; 南尚哉; 佐光一也; 武井麻子; 久原真; 玉腰暁子; 佐藤典宏; 矢部一郎, 臨床神経学(Web), 64, 11, 2024 - 北海道における多系統萎縮症レジストリ研究:HoRC-MSA2014・2023
松島理明; 足澤萌奈美; 工藤彰彦; 佐久嶋研; 金谷泰宏; 西本尚樹; 澤田潤; 松岡健; 上杉春雄; 南尚哉; 佐光一也; 武井麻子; 久原真; 玉腰暁子; 佐藤典宏; 佐々木秀直; 矢部一郎, 臨床神経学(Web), 63, 11, 2023 - 北海道における多系統萎縮症レジストリ研究:HoRC-MSA2014-2022
松島理明; 足澤萌奈美; 工藤彰彦; 佐久嶋研; 金谷素宏; 西本尚樹; 澤田潤; 松岡健; 久原真; 上杉春雄; 南尚哉; 佐光一也; 武井麻子; 玉腰暁子; 佐藤典宏; 佐々木秀直; 矢部一郎, 臨床神経学(Web), 62, 12, 2022 - 北海道における多系統萎縮症レジストリ研究:HoRC-MSA2014-2021
松島理明; 佐久嶋研; 金谷泰宏; 西本尚樹; 澤田潤; 松岡健; 久原真; 上杉春雄; 南尚哉; 佐光一也; 武井麻子; 玉腰暁子; 佐藤典宏; 佐々木秀直; 矢部一郎, 臨床神経学(Web), 62, 4, 2022 - リハビリテーション職種が知っておくべき臨床統計 基礎から最新の話題まで 14.診断法の統計的評価（感度・特異度・ROC曲線等）
西本 尚樹, Journal of Clinical Rehabilitation, 30, 12, 1259, 1259, Oct. 2021
医歯薬出版(株), Japanese - 北海道における多系統萎縮症レジストリ研究:HoRC-MSA2014-2019
松島理明; 佐久嶋研; 矢部一郎; 金谷泰宏; 西本尚樹; 松岡健; 澤田潤; 上杉春雄; 上杉春雄; 佐光一也; 武井麻子; 玉腰暁子; 下濱俊; 佐藤典宏; 菊地誠志; 佐々木秀直; 佐々木秀直, 臨床神経学(Web), 60, 1, 2020 - 北海道における多系統萎縮症レジストリ研究:HoRC-MSA2014-2019
松島 理明; 佐久嶋 研; 矢部 一郎; 金谷 泰宏; 西本 尚樹; 松岡 健; 澤田 潤; 上杉 春雄; 佐光 一也; 武井 麻子; 玉腰 暁子; 下濱 俊; 佐藤 典宏; 菊池 誠志; 佐々木 秀直, 臨床神経学, 60, 1, 95, 95, Jan. 2020, [Peer-reviewed]
(一社)日本神経学会, Japanese - 北海道の将来における医療資源の適正配置―将来推計人口と推計傷病別患者数によるシミュレーション分析―
谷川琢海; 藤原健祐; 西本尚樹; 大場久照; 小笠原克彦, 医療情報学連合大会プログラム・抄録集, 38th, 438, 22 Nov. 2018
Japanese - 将来推計人口メッシュに基づく医療資源の適正配置分析―北海道における患者アクセシビリティの最適化―
谷川琢海; 大場久照; 西本尚樹; 小笠原克彦, 日本医療情報学会春季学術大会プログラム・抄録集, 22nd, 160‐161, 2018
Japanese - 放射線技術学における研究倫理 臨床研究における倫理(2)
西本 尚樹; 小笠原 克彦, 日本放射線技術学会雑誌, 73, 1, 69, 77, Jan. 2017
(公社)日本放射線技術学会, Japanese - A市の救急電話相談事業の現状と課題 相談員へのグループインタビューをとおして
中村 圭佐; 松原 三智子; 石川 幸司; 西本 尚樹; 岡崎 哲夫; 林 裕子, 北海道科学大学研究紀要, 42, 77, 84, Dec. 2016
A市の救急電話相談事業「#7119」の相談員が捉えた現状と思いや困難についてグループインタビューを実施し、質的帰納的に分析を行った。対象者は女性5名であった。相談員の平均経験年数は約18ヵ月であり、臨床における看護師経験の平均年数は約12.0年であった。インタビューの内容について、切片化したラベルと2度にわたるグループ編成から命名された2種類の表札を作成した。1度目のグループ編成で命名された表札を「第1ステップの表札」2度目のグループ編成で命名された表札を「第2ステップの表札」として記述した。分析の結果、サービス対象外の相談が多く寄せられていること、相談者の特徴として救急車の利用よりも電話相談における解決を望む傾向があること、相談員らの心苦しさや葛藤などが明らかになった。看護師としての豊かな経験や自律性によってプロトコールに添った対応は順調に行われていた。今後の課題としてシステム上の検索および入力機能の改善があげられた。, 北海道科学大学, Japanese - 札幌市の救急電話相談「救急安心センターさっぽろ」における小児の電話相談内容の実態
石川 幸司; 松原 三智子; 中村 圭佐; 西本 尚樹; 市川 正人; 岡崎 哲夫; 林 裕子, 北海道科学大学研究紀要, 42, 71, 76, Dec. 2016
札幌市の救急電話相談「救急安心センターさっぽろ」の2年間の実施状況から、小児用プロトコールの利用状況を調査した。プロトコールは小児用は18種類となっており、15歳以下を小児と規定していた。電話相談対象者より年齢が15歳以下であった13637件(1年目5592件、2年目8045件)を分析対象とした。年間を通して使用されたプロトコール別の順位を見ると、1年目、2年目ともに発熱が第1位であり、次いで頭部・頸部外傷、嘔気・嘔吐であった。これらのプロトコールの使用割合は1年目2年目で有意差はなかった。2年間での救急群は7161件(52.5%)、非救急群は6476件(47.5%)であった。1年目の救急群は3000件(53.6%)、2年目の救急群は4161件(51.7%)であった。救急群で使用されたプロトコールは1年目2年目ともに発熱が1位であり、次いで嘔気・嘔吐、頭部・頸部外傷であった。非救急群では、1年目2年目ともに発熱が第1位、次いで頭部・頸部外傷であった。, 北海道科学大学, Japanese - 放射線技術学における研究倫理 臨床研究における倫理(1)
西本 尚樹; 小笠原 克彦, 日本放射線技術学会雑誌, 72, 12, 1268, 1276, Dec. 2016
(公社)日本放射線技術学会, Japanese - 救急電話相談「救急安心センターさっぽろ」における緊急度が高い症状の電話相談の実態
石川 幸司; 松原 三智子; 中村 圭佐; 西本 尚樹; 岡崎 哲夫; 林 裕子, 日本公衆衛生学会総会抄録集, 75回, 576, 576, Oct. 2016
日本公衆衛生学会, Japanese - 札幌市の救急電話相談「救急安心センターさっぽろ」における緊急度が高い症状を有する電話相談者への対応
石川 幸司; 松原 三智子; 中村 圭佐; 西本 尚樹; 市川 正人; 岡崎 哲夫; 林 裕子, 北海道科学大学研究紀要, 41, 115, 121, Sep. 2016
札幌市の救急電話相談の2年間の実施状況から、緊急度が高いと判定される電話相談において、プロトコルの運用状況を調査し、実際に看護師がどのように電話対応しているかを明らかにし、事業の効果と課題について検討した。救急安心センターさっぽろで受け付けた電話救急医療相談で記録されたデータを対象とした。最終的には5240件の電話相談を分析対象とした。緊急度の高いAカテゴリーのプロトコルを使用して電話対応していた割合は1年目と2年目では同程度であり、変化がないことから、プロトコルに沿った適切な対応ができていると考えられた。現在使用している緊急度が高いAカテゴリーのプロトコルの運用において、病態学的にも妥当と考えられる判定をしており、大きく問題となる傾向は認められず、看護師のみで運営するプロトコルとして安全に稼働できていると推測された。今後は実際に救急車で搬送された症例との照らし合わせなど、データの集積が必要であると考えられた。, 北海道科学大学, Japanese - 札幌市における救急電話相談「救急安心センターさっぽろ」の現状
石川 幸司; 松原 三智子; 西本 尚樹; 中村 圭佐; 市川 正人; 岡崎 哲夫; 林 裕子, 北海道科学大学研究紀要, 40, 71, 76, Mar. 2016
札幌市における救急電話相談「救急安心センターさっぽろ」の現状について報告した。受け付けた電話相談総数30195件(最大解析対象集団、FAS)から医療機関案内7288件(24.1%)および間違いやいたずらなどの電話5190件(17.2%)を除外した17717件のうち、札幌市以外からの入電およびプロトコールで救急判定の記入がなかった電話相談を除外したものをプロトコールに基づく相談件数(解析対象集団、PPS)(17416件)とした。1年間の電話相談において、1日の平均件数は82.7件であった。電話相談の対応種別では医療機関案内が24.1%、救急医療相談が58.7%、間違い電話やいたずら電話などが17.2%で、プロトコールを利用した電話相談件数は17586件(58.2%)、監督員である医師に電話相談したのは41件(0.2%)であった。PPSのうち、年間を通して症状別に順位を見ると、小児の発熱1118件(7.3%)が第1位であり、次いで腹痛、小児の頭部・頸部外傷の順であった。PPSにおいて、救急群は10948件(62.9%)、非救急群は6468件(37%)であった。, 北海道科学大学, Japanese - 札幌市における救急電話相談「救急安心センターさっぽろ」の実態
石川 幸司; 松原 三智子; 西本 尚樹; 中村 圭佐; 岡崎 哲也; 林 裕子, 看護総合科学研究会誌, 16, 2, 59, 59, Jan. 2016
看護総合科学研究会, Japanese - 札幌市電話救急相談(#7119)の相談件数を対象にした平均変動の解析
西本 尚樹; 松原 三智子; 石川 幸司; 林 裕子; 中村 圭佐; 岡崎 哲夫, 医療情報学連合大会論文集, 35回, 298, 299, Nov. 2015
(一社)日本医療情報学会, Japanese - 札幌市における救急電話相談「救急安心センターさっぽろ」の現状(第1報)
中村 圭佐; 松原 三智子; 西本 尚樹; 林 裕子; 石川 幸司; 岡崎 哲夫, 日本公衆衛生学会総会抄録集, 74回, 484, 484, Oct. 2015
日本公衆衛生学会, Japanese - 札幌市における救急電話相談「救急安心センターさっぽろ」の現状(第2報)
石川 幸司; 松原 三智子; 西本 尚樹; 中村 圭佐; 林 裕子; 岡崎 哲夫, 日本公衆衛生学会総会抄録集, 74回, 484, 484, Oct. 2015
日本公衆衛生学会, Japanese - 札幌市における救急電話相談「救急安心センターさっぽろ」の現状(第3報)
松原 三智子; 西本 尚樹; 石川 幸司; 中村 圭佐; 林 裕子; 岡崎 哲夫, 日本公衆衛生学会総会抄録集, 74回, 484, 484, Oct. 2015
日本公衆衛生学会, Japanese - 相関構造をもつROC曲線に対する検出力の算出
西本 尚樹; 伊藤 陽一; 菊池 明泰; 佐々木 恒平; 奥山 豪; 織田 圭一; 真田 哲也; 板東 道夫; 早川 修; 北間 正崇, 北海道科学大学研究紀要, 39, 79, 82, Mar. 2015
北海道科学大学, Japanese - 拡散光を用いた内シャント透視のための基礎的検討
北間 正崇; 菅谷 真之介; 清水 久恵; 山下 政司; 奥山 豪; 菊池 明泰; 西本 尚樹; 清水 孝一, 北海道科学大学研究紀要, 39, 101, 106, Mar. 2015
北海道科学大学, Japanese - 培地経由バイスタンダー効果に対する数理モデルの開発
佐々木 恒平; 早川 修; 真田 哲也; 奥山 豪; 菊池 明泰; 西本 尚樹; 板東 道夫; 織田 圭一; 北間 正崇, 北海道科学大学研究紀要, 39, 69, 74, Mar. 2015
低密度培養細胞環境における放射線誘導バイスタンダー効果(RIBE)について検討するため、Xiaらのモデルを改良したPoisson統計に基づくシグナル再放出モデルを開発し、Schettinoらの行った軟X線マイクロビームによる単一細胞照射実験を対象とした確率的モデルを構築してシミュレーションを行った。このシミュレーションにより、RIBEによって損傷を受けた細胞からのシグナル再放出確率を推定した。さらにRIBEの伝達時間について検討したところ、培養皿全体ではRIBEによる細胞損傷は約60時間で飽和することが示唆された。また照射細胞からの距離毎に解析を行い、シグナル伝達時間の距離依存性を確認した。, 北海道科学大学, Japanese - 201-Tl心筋血流検査におけるoff-peak法を用いた収集条件の検討
菊池 明泰; 北間 正崇; 奥山 豪; 西本 尚樹; 佐々木 恒平, 北海道科学大学研究紀要, 39, 75, 78, Mar. 2015
201-Tl心筋血流検査におけるカウント収集条件について、off-peak法によりエネルギーピークの設定を変更して面ファントムで比較検討した。エネルギーウィンドウとして(A)71keV±10.0%、(B)77keV±14.5%、(C)71keV±10.0%+167keV±7.5、(D)77keV±14.5%+167keV±7.5の4条件を設定し、Profile curveを散乱体(SC)の有無で比較したところ、SC(+)では条件Dが他の条件と比較してカウントも多く、欠損部分のコントラストも十分あり、散乱線含有の少ない良好な画像が得られた。SC(-)では全体にカウントは多かったが、最もカウントがあり欠損コントラストもあるのは条件Dであった。次にコリメータがLEGP散乱体(+)の条件下でのMulti defect phantom内のカウントについて、関心領域を統一して比較した。その結果、一般的な収集条件(A)に比較して条件Dでは約30%のカウント増加がみられ、本法が有用であることが示唆された。, 北海道科学大学, Japanese - 北海道における多系統萎縮症の疫学的実態 HoRC-MSAプロジェクト
佐久嶋 研; 西本 尚樹; 松島 理明; 野島 正寛; 矢部 一郎; 森 満; 佐藤 典宏; 佐々木 秀直, 臨床神経学, 55, 2, 131, 131, Feb. 2015
(一社)日本神経学会, Japanese - 北海道における多系統萎縮症の疫学的実態:HoRC‐MSAプロジェクト
佐久嶋研; 西本尚樹; 松島理明; 野島正寛; 矢部一郎; 森満; 佐藤典宏; 佐々木秀直, 臨床神経学(Web), 55, 2, 131(J‐STAGE), 131, Feb. 2015
(一社)日本神経学会, Japanese - 北海道における多系統萎縮症の疫学的実態:HoRC‐MSAプロジェクト
佐久嶋研; 西本尚樹; 野島正寛; 松島理明; 矢部一郎; 佐藤典宏; 森満; 佐々木秀直, 日本神経学会学術大会プログラム・抄録集, 55th, Suppl., 507, S38, Dec. 2014
(一社)日本神経学会, Japanese - 心臓専用半導体検出器を用いた欠損検出能の検討 機種および使用核種の違いによる描出能の比較
菊池 明泰; 藤原 征; 久保 和弘; 伊藤 達郎; 塩田 明佳; 織田 圭一; 西本 尚樹, 日本放射線技術学会雑誌, 70, 9, 981, 981, Sep. 2014
(公社)日本放射線技術学会, Japanese - 放射線技術学で必要な基礎統計学 まとめ データの品質と解析結果の解釈
西本 尚樹; 大場 久照; 小笠原 克彦; 伊藤 陽一, 日本放射線技術学会雑誌, 70, 2, 155, 162, Feb. 2014
(公社)日本放射線技術学会, Japanese - 北海道における多系統萎縮症の疫学的実態 HoRC-MSAプロジェクト
佐久嶋 研; 西本 尚樹; 松島 理明; 野島 正寛; 矢部 一郎; 森 満; 佐藤 典宏; 佐々木 秀直, 臨床神経学, 54, 1, 89, 89, Jan. 2014
(一社)日本神経学会, Japanese - Stage III結腸癌の術後補助化学療法としてのFOLFOX療法の第II相臨床試験:NORTH
中村路夫; 結城敏志; 福島拓; 高橋典彦; 七戸俊明; 三澤一仁; 久須美貴哉; 中村文隆; 宮城島拓人; 岩永一郎; 畑中一映; 大森一吉; 西本尚樹; 伊藤陽一; 小松嘉人, 日本癌治療学会学術集会(CD-ROM), 52nd, ROMBUNNO.P48-1, 2014
Japanese - 放射線技術学で必要な基礎統計学 サンプルサイズ
谷 祐児; 大場 久照; 西本 尚樹; 小笠原 克彦; 伊藤 陽一, 日本放射線技術学会雑誌, 69, 12, 1436, 1443, Dec. 2013
(公社)日本放射線技術学会, Japanese - 放射線技術学で必要な基礎統計学 信頼性の解析(κ係数とICC)
西本 尚樹; 小笠原 克彦; 伊藤 陽一, 日本放射線技術学会雑誌, 69, 11, 1320, 1330, Nov. 2013
(公社)日本放射線技術学会, Japanese - 放射線技術学で必要な基礎統計学 多群の比較 ノンパラメトリック検定
谷川 琢海; 西本 尚樹; 小笠原 克彦; 伊藤 陽一, 日本放射線技術学会雑誌, 69, 8, 885, 894, Aug. 2013
(公社)日本放射線技術学会, Japanese - 放射線技術学で必要な基礎統計学 多群の比較(2)
西本 尚樹; 小笠原 克彦; 伊藤 陽一, 日本放射線技術学会雑誌, 69, 7, 806, 815, Jul. 2013
(公社)日本放射線技術学会, Japanese - 放射線技術学で必要な基礎統計学 多群の比較(1)
西本 尚樹; 小笠原 克彦; 伊藤 陽一, 日本放射線技術学会雑誌, 69, 6, 679, 688, Jun. 2013
(公社)日本放射線技術学会, Japanese - 放射線技術学で必要な基礎統計学 2群の比較(4)
谷川原 綾子; 西本 尚樹; 小笠原 克彦; 伊藤 陽一, 日本放射線技術学会雑誌, 69, 5, 568, 574, May 2013
(公社)日本放射線技術学会, Japanese - 放射線技術学で必要な基礎統計学 2群の比較 ノンパラメトリック検定
大場 久照; 西本 尚樹; 小笠原 克彦; 伊藤 陽一, 日本放射線技術学会雑誌, 69, 4, 434, 441, Apr. 2013
(公社)日本放射線技術学会, Japanese - 放射線技術学で必要な基礎統計学 2群の比較(2)
西本 尚樹; 小笠原 克彦; 伊藤 陽一, 日本放射線技術学会雑誌, 69, 2, 208, 216, Feb. 2013
(公社)日本放射線技術学会, Japanese - 放射線技術学で必要な基礎統計学 2群の比較(1)
横岡 由姫; 西本 尚樹; 小笠原 克彦; 伊藤 陽一, 日本放射線技術学会雑誌, 69, 1, 114, 122, Jan. 2013
(公社)日本放射線技術学会, Japanese - Educational Lecture : Statistical Methods for Radiologic Research (3) Descriptive Statistics and Data Visualization
谷川 琢海; 西本 尚樹; 小笠原 克彦, 日本放射線技術学会雑誌, 68, 11, 1546, 1554, Nov. 2012
日本放射線技術学会, Japanese - 放射線技術学で必要な基礎統計学 研究デザイン
西本 尚樹; 小笠原 克彦; 伊藤 陽一, 日本放射線技術学会雑誌, 68, 10, 1392, 1400, Oct. 2012
(公社)日本放射線技術学会, Japanese - Finite Mixture Modelを用いた冠動脈狭窄度と冠動脈周囲脂肪組織との関連の探索的研究
宮本佳史子; 真鍋徳子; 西本尚樹; 伊藤陽一; 寺江聡; 白土博樹, 統計関連学会連合大会講演報告集, 2012, 66, Sep. 2012, [Peer-reviewed]
Japanese - 冠動脈周囲脂肪量を指標としたFinite Mixture Modelによるサブポピュレーションの推定
西本尚樹; 真鍋徳子; 宮本佳史子; 伊藤陽一; 寺江聡; 白土博樹, 統計関連学会連合大会講演報告集, 2012, 278, Sep. 2012
Japanese - 放射線技術学で必要な基礎統計学 医療統計学概論
西本 尚樹; 小笠原 克彦; 伊藤 陽一, 日本放射線技術学会雑誌, 68, 8, 1038, 1045, Aug. 2012
(公社)日本放射線技術学会, Japanese - Semi-automated Extraction of Brain Hematoma from CT images Using Improved Region-Growing Method
KITAGAWA Tsuyoshi; YAGAHARA Ayako; FUJIWARA Kensuke; INOUE Go; NISHIMOTO Naoki; UESUGI Masahito; OGASAWARA Katsuhiko, IEICE technical report., 111, 127, 19, 23, 05 Jul. 2011
The purpose of this study is to investigate the feasibility of the semi-automatic software for the estimation of brain hemorrhage volume. When a patient suffers brain hemorrhage, the expert manually measures the volume on CT images in daily practice. We developed the measurement software with Improved Region-Growing method (IRG method). The volume was 58.21ml for the manual measurement and 50.81ml for IRG in phantom experiment, respectively. We found 0.98 in correlation between the manual method and IRG in hematoma volume on CT images. Threshold detection was remained as a future work., The Institute of Electronics, Information and Communication Engineers, Japanese - Let's Write a Research Paper Soon after Returning ; Introduction of the International Journals Related to Radiological Technology and Members' Real Experiences
TANAKA Rie, Japanese Journal of Radiological Technology, 67, 1, 98, 116, 20 Jan. 2011
Japanese Society of Radiological Technology, Japanese - 医療情報分野 (教育講座 研究成果を世界に向けて発信しよう!(第7回)帰国しました,さっそく論文にしましょう!(投稿先の紹介,経験談))
西本 尚樹, 日本放射線技術学会雑誌, 67, 1, 108, 110, Jan. 2011
日本放射線技術学会, Japanese - 放射線画像診断レポートからの疾患名及びサイズ表現の抽出
西本尚樹; 寺江聡; 谷川原綾子; 横岡由姫; 辻真太朗; 上杉正人; 小笠原克彦, 医療情報学連合大会論文集, 30th, 413-414, 19 Nov. 2010
Japanese - 3T‐MRI Tagging撮像を用いた正常及び梗塞心筋の壁厚変化のモデル化および心筋梗塞進展度との関連性の解析
宮本佳史子; 大山徳子; 伊藤陽一; 西本尚樹; 寺江聡; 白土博樹, 統計関連学会連合大会講演報告集, 2010, 220, Sep. 2010
Japanese - A Literature Search Technique : An Information Retrieval for Radiologic Practice and Research
NISHIMOTO Naoki, Japanese Journal of Radiological Technology, 66, 7, 802, 807, 20 Jul. 2010
Japanese Society of Radiological Technology, Japanese - American Medical Informatics Association : AMIA, 米国医療情報学会
西本 尚樹; 前沢 政次, 日本放射線技術學會雜誌, 66, 2, 163, 163, 20 Feb. 2010
Japanese - 6. How to Attend the Meeting Effectively?Information on Meeting Schedule, Event, Service, and Dining
Tanaka e; al. Rie, Japanese Journal of Radiological Technology, 66, 10, 1343, 1356, 2010
Japanese Society of Radiological Technology - 4. Recommended way of learning English
Nishimoto e; al. Naoki, Japanese Journal of Radiological Technology, 66, 4, 385, 388, 2010
Japanese Society of Radiological Technology - Improved Dual SnakesによるCT・MRI画像からの側脳室の抽出精度評価
谷川原綾子; 西本尚樹; 上杉正人; 藤原健祐; 北川剛; 井上剛; 寺下貴美; 小笠原克彦, 医療情報学連合大会論文集, 29th, 524, 525, 21 Nov. 2009
(一社)日本医療情報学会, Japanese - Hierarchy Structuring for Mammography Technique by Interpretive Structural Modeling Method
KUDO Nozomi; KUROWARABI Kunio; TERASHITA Takayoshi; NISHIMOTO Naoki; OGASAWARA Katsuhiko, Japanese Journal of Radiological Technology, 65, 10, 1385, 1390, 20 Oct. 2009
Participation in screening mammography is currently desired in Japan because of the increase in breast cancer morbidity. However, the pain and discomfort of mammography is recognized as a significant deterrent for women considering this examination. Thus quick procedures, sufficient experience, and advanced skills are required for radiologic technologists. The aim of this study was to make the point of imaging techniques explicit and to help understand the complicated procedure. We interviewed 3 technologists who were highly skilled in mammography, and 14 factors were retrieved by using bra..., Japanese Society of Radiological Technology, Japanese - Developing and Evaluating an Auto-retrieval Algorithm for Abbreviations in Academic Articles
WAKOH Michika; NISHIMOTO Naoki; UESUGI Masahito; TERASHITA Takayoshi; OGASAWARA Katsuhiko, Japanese Journal of Radiological Technology, 65, 8, 1025, 1031, 20 Aug. 2009
The purpose of this study was to develop an automated acquisition support for the semantics of abbreviations and evaluate its performance with respect to academic articles. Our goal was to support the maintenance of an institution-specific semantics inventory for abbreviations on a continuous basis. We retrieved articles from MEDLINE with the keyword “Liver [MeSH],” and 100 abstracts were randomly selected. Abbreviations and their full forms were retrieved using original Java software based on the following rules. (1) Searching the parentheses in the abstracts, the words inside the parenthe..., Japanese Society of Radiological Technology, Japanese - 放射線技術者のための医用言語処理入門-part 4-(用語解説)
西本 尚樹; 上杉 正人; 櫻井 恒太郎; 小笠原 克彦, 日本放射線技術学会医療情報分科会雑誌, 0, 12, 77, 82, 01 Apr. 2009
公益社団法人日本放射線技術学会, Japanese - 事後確率推定に基づく医学コーパス構築支援
西本尚樹; 寺江聡; 上杉正人; 谷川原綾子; 小笠原克彦, 医療情報学連合大会論文集, 28th, 957-958, 958, 22 Nov. 2008
(一社)日本医療情報学会, Japanese - 放射線技術者のための医用言語処理入門(用語解説)
上杉 正人; 西本 尚樹; 櫻井 恒太郎; 小笠原 克彦, 日本放射線技術学会医療情報分科会雑誌, 0, 11, 71, 76, 01 Oct. 2008
公益社団法人日本放射線技術学会, Japanese - Pilot Study of Domain-specific Terminology Adaptation for Morphological Analysis : Research on Unknown Terms in National Examination Documents of Radiological Technologists
Tsuji Shintarou; Nishimoto Naoki; Ogasawara Katsuhiko, Japanese Journal of Radiological Technology, 64, 7, 791, 794, 20 Jul. 2008
Although large medical texts are stored in electronic format, they are seldom reused because of the difficulty of processing narrative texts by computer. Morphological analysis is a key technology for extracting medical terms correctly and automatically. This process parses a sentence into its smallest unit, the morpheme. Phrases consisting of two or more technical terms, however, cause morphological analysis software to fail in parsing the sentence and output unprocessed terms as "unknown words." The purpose of this study was to reduce the number of unknown words in medical narrative text ..., Japanese Society of Radiological Technology (JSRT), Japanese - 医療技術者のための医用言語処理入門(用語解説)
西本 尚樹; 上杉 正人; 櫻井 恒太郎; 小笠原 克彦, 日本放射線技術学会医療情報分科会雑誌, 0, 10, 46, 52, 01 Apr. 2008
公益社団法人日本放射線技術学会, Japanese - 医学用語抽出モジュールの開発—放射線読影レポートを対象として
西本尚樹; 寺江聡; 上杉正人; 寺下貴美; 小笠原克彦; 遠藤晃; 櫻井恒太郎, 医療情報学連合大会論文集, 27th, 376-377, 23 Nov. 2007
Japanese - 看護業務タイムスタディにおける業務間遷移確率を用いたシミュレーション
寺下 貴美; 佐藤 ひとみ; 遠藤 晃; 石井 英樹; 西本 尚樹; 上杉 正人; 小笠原 克彦; 櫻井 恒太郎; 前沢 政次, 医療情報学連合大会論文集, 27回, 306, 309, Nov. 2007
(一社)日本医療情報学会, Japanese - 医療技術者のための医用言語処理入門(用語解説)
西本尚樹; 上杉正人; 櫻井恒太郎; 小笠原克彦, 9, 59, 67, Oct. 2007 - 画像診断レポートにおける文字間遷移確率の分布
西本尚樹; 上杉正人; 寺江聡; 谷川琢海; 寺下貴美; 遠藤晃; 小笠原克彦; 櫻井恒太郎, 医療情報学連合大会論文集, 26th, 816-817, 30 Oct. 2006
Japanese
- Health Informatics Information Technology
日本医療情報学会; 医療情報技師育成部会
篠原出版新社, 10 Jun. 2022, 9784867058145, 362, Japanese - 核医学技術総論
福喜多博義; 日本核医学技術学会, 第１部理工学等に関する基礎知識 第４章医用統計学
山代印刷出版部, 18 Oct. 2021, 4990420705, 633, 29-39, Japanese, Scholarly book - 臨床研究アウトプット術
前田, 圭介; 室谷, 健太, 7．診断検査の解析
中外医学社, 27 Feb. 2020, 4498048784, 386, 219-230, Japanese, Scholarly book
- 深層学習と意味解析を組み合わせた臨床研究データを標準化する手法の開発
科学研究費助成事業 若手研究(B)
01 Apr. 2017 - 31 Mar. 2021
西本 尚樹
2019年度の成果として、医学用語のコーティングに統計解析パッケージのSASを用いて、既存の臨床試験の変数mappingを行った。昨年度の研究から引き続いて、プログラミング言語Pythonを使用して、変数のmappingを行っている。情報ソースは、統計解析パッケージSAS(SAS Institute Inc., Cary, NC, USA)に収録されている3,264人分のBMIと年齢のみが変数のサンプルデータ(BMIデータ)を用いた。サンプルデータは、米国のthe national center for health statisticsが公開しているnational health and nutrition examination survey (NHANES)の1999-2000年及び2001-2002年に調査された8250人の男性のデータであり、公開されているサンプルデータセットは、さらにサンプリングが行われているものである。この変数名に対して、semantic integrationの技術より、OWL(Ontology Web Language) で記述される"owl:equivalentClass", "owl:equivalentProperty"及び"owl:sameAs"を適用し、電子カルテデータの変数名や既存の試験のデータベース定義書から変数間のつながり、変換過程を記述する試みを行った。Semantic integrationは、実社会での応用例が集積されつつあるため、文献から、アルゴリズムの収集・分類を行った。
深層学習のアルゴリズムの適用について2019年度の進捗として、ワークステーションにGPUを増設し、PythonによるChainerの構築利用環境の構築を行った。自然言語処理と親和性の高いGroovyによる環境構築も同時に進めている。
日本学術振興会, 若手研究(B), 17K15866 - Study for increase the efficiency of data management practice in doctor initiated clinical trial
Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
2011 - 2012
NISHIMOTO Naoki
A web based-system was developed for supporting the patient entry control and we measured the efficiency on data management practice. Collecting log of the practice clarified the difference in timing of case report form return by the institutions. Recycling knowledge and knowledge management of the system development was required. Four layered, 57 concepts of basic biostatistics were developed as a knowledge representation.
Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, 23700332
