Researcher basic information

• Ph. D. (Fisheries Science), Hokkaido University, Mar. 2024

• https://researchmap.jp/ryohei_surugaya?lang=en

• https://orcid.org/0000-0001-5461-8728
• https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202401001395840292

• 31002199

• https://orcid.org/0000-0001-5461-8728

• 202401001395840292

• Bachelor's degree program, School of Fisheries Sciences
• Master's degree program, Graduate School of Fisheries Sciences
• Doctoral (PhD) degree program, Graduate School of Fisheries Sciences

Research activity information

• Oct. 2025, 北海道大学, 第11回北海道大学部局横断シンポジウム研究助成採択 金賞
  チョウザメの安定種苗生産実現に向けたプロスタグランジン合成制御機構の解明
  駿河谷諒平;藤森千加
• Mar. 2025, 日本動物学会北海道支部, 日本動物学会北海道支部第69回大会優秀発表賞
  アムールチョウザメの良質卵および不良卵における母性mRNA量の比較
  中野玖里子;駿河谷諒平;足立伸次;井尻成保, Japan society
• Mar. 2024, 北海道大学大学院水産科学院, 伊藤一隆賞
  駿河谷諒平, Others, Japan
• Nov. 2023, 日本比較内分泌学会, 第47回日本比較内分泌学会大会学生優秀ポスター発表賞
  排卵期におけるアムールチョウザメ2種のptgs2の発現動態と転写調節機構
  駿河谷諒平;東坂和樹;足立伸次;井尻成保, Japan society, Japan
• Nov. 2019, 日本水産学会, 令和元年度日本水産学会北海道支部大会最優秀学生講演賞
  アムールチョウザメ卵濾胞の外観と排卵の関係
  駿河谷諒平, 井尻成保, 足立伸次, Japan society, Japan

• Sexual dimorphic expression pattern of sex differentiation–related genes and the W–chromosome–specific gene during gonadal sex differentiation in Kaluga sturgeon (Huso dauricus)
  Kazuki Tousaka; Ryohei Surugaya; Shun Yoshida; Shinji Adachi; Shigeho Ijiri
  Aquaculture, 15 Jul. 2026, [Peer-reviewed]
  English, Scientific journal
• Generation of WW Superfemale Sturgeons Through Hormonal Masculinization of ZW Females
  Ryohei Surugaya; Kazuki Tousaka; Shun Yoshida; Shinji Adachi; Shigeho Ijiri
  Fishes, 02 Dec. 2025, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal, In sturgeon aquaculture, all-female production is desirable due to the high value of caviar. Genetic sexing and the production of WW superfemales are important steps toward achieving this. In this study, we identified the WSR and ZSR primers for amplification of W- and Z-specific regions, respectively. WSR primers were designed on the gene W-linked RT RNase H-like domain containing protein (rnhW). The polymerase chain reaction (PCR) bands were obtained with the WSR primer only in phenotypic female sturgeons, indicating that stable genetic sexing was achieved in most species, including those captured around Hokkaido. Moreover, rnhW showed female-specific expression in the gonads during early sex differentiation in kaluga and Amur sturgeon. ZSR primers were developed from the orofacial cleft 1 candidate gene 1 protein homolog. Clear and distinct gel band patterns for ZZ, ZW, and WW genotypes were obtained using WSR and ZSR primers, consistent with genotypic estimations by quantitative PCR. This consistency confirmed the presence of WW superfemales among offspring produced by fertilizing ZW females with ZW pseudomales masculinized using 17α-methyltestosterone. Our findings provide new insights into the mechanisms of sex determination and differentiation in sturgeons, bringing the establishment of an all-female production system within reach.
• Identification of maturation-inducing steroid in sturgeons via comprehensive analyses of steroids produced during oocyte maturation.
  Yuya Hasegawa; Ryohei Surugaya; Kazuki Tousaka; Shinji Adachi; Shigeho Ijiri
  The Journal of steroid biochemistry and molecular biology, 238, 106442, 106442, Apr. 2024, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Although 17α, 20β-dihydroxy-4-pregnen-3-one (DHP) and 17α, 20β, 21-trihydroxy-4-pregnen-3-one (20β-S) have been identified as maturation-inducing steroids (MIS) in several teleosts, to date, no MISs have been identified in sturgeons. As it remains possible that an unidentified steroid is an MIS in sturgeons, this study aimed to identify a sturgeon MIS via comprehensive analyses and maturation-inducing (MI) assay of C21 steroids. In vivo and in vitro comprehensive analyses of C21 steroids revealed that serum DHP concentrations were rapidly elevated in the oocyte maturation phase and the DHP production level was notably high among C21 steroids. MI assay indicated that the MI activity of DHP, 17α-hydroxyprogesterone (17OHP), a precursor of DHP, 17α, 20α-dihydroxy-4-pregnen-3-one (αDHP), and 20β-S was high among C21 steroids, but the MI activity of these steroids were similar. In the C21 steroids produced in ovarian follicles during oocyte maturation, 17OHP, αDHP, and unidentified compounds had a low production level, and 20β-S was suggested to be metabolized from DHP after oocyte maturation. Against this background, this study concluded that DHP is a steroid that possesses strong MI activity and is highly produced during oocyte maturation. Although this study could not identify an MIS in sturgeons by fractionation of plasma and subsequent bio assay, it was suggested that DHP is a major MIS in sturgeons.
• mRNA expression profiles of proteolytic genes during the process of ovulation in ovarian follicles of sturgeons
  Ryohei Surugaya; Yuya Hasegawa; Kazuki Tousaka; Shinji Adachi; Shigeho Ijiri
  Fisheries Science, 90, 1, 41, 51, Jan. 2024, [Peer-reviewed], [Lead author]
  Scientific journal
• Soy isoflavones induce feminization of Japanese eel (Anguilla japonica)
  Hiroyuki Inaba; Yuzo Iwata; Takashi Suzuki; Moemi Horiuchi; Ryohei Surugaya; Shigeho Ijiri; Ai Uchiyama; Ryoko Takano; Seiji Hara; Takashi Yazawa; Takeshi Kitano
  International Journal of Molecular Sciences, 26 Dec. 2022, [Peer-reviewed]
  Scientific journal
• Changes in Ovulation-Related Gene Expression during Induced Ovulation in the Amur Sturgeon (Acipenser schrenckii) Ovarian Follicles
  Ryohei Surugaya; Yuya Hasegawa; Shinji Adachi; Shigeho Ijiri
  International Journal of Molecular Sciences, 29 Oct. 2022, [Peer-reviewed], [Lead author]
  Scientific journal
• Regulation of 17α-Hydroxyprogesterone production during induced oocyte maturation and ovulation in Amur sturgeon (Acipenser schrenckii)
  Yuya Hasegawa; Ryohei Surugaya; Shinji Adachi; Shigeho Ijiri
  Journal of Marine Science and Engineering, 10, 1, 86, 86, {MDPI} {AG}, 10 Jan. 2022, [Peer-reviewed]
  English, Scientific journal, In several teleosts, 17α, 20β-dihydroxy-4-pregnen-3-one (DHP) has been identified as a maturation-inducing steroid. DHP is synthesized from 17α-hydroxyprogesterone (17OHP) by 17β-hydroxysteroid dehydrogenase type 12-like (hsd17b12L). Along with 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD), 17α-hydroxylase and C17-20 lyase are associated with 17OHP production. This study aimed to determine the roles of Amur sturgeon hsd3b, P450c17-I (cyp17a1), and P450c17-II (cyp17a2) in 17OHP production and to examine their enzyme activity and mRNA expression pattern during oocyte maturation. In the sturgeons used in this study, hsd3b encoded 3β-HSD, cyp17a1 catalyzed 17α-hydroxylase production with C17-20 lyase activity, and cyp17a2 processed 17α-hydroxylase activity alone. In the ovarian follicles of individuals that underwent induced ovulation, hsd3b mRNA levels increased rapidly, cyp17a1 expression was downregulated, and cyp17a2 expression was upregulated during oocyte maturation. Finally, an in vitro study revealed that salmon pituitary extract (SPE) stimulation rapidly induced hsd3b expression, whereas cyp17a1 expression was downregulated. In vitro, cyp17a2 expression did not rapidly increase with SPE stimulation. This rapid upregulation of hsd3b during oocyte maturation was first observed in teleosts. It was suggested that hsd17b12L expression is upregulated after 17OHP production, which is regulated by hsd3b, cyp17a1, and cyp17a2, resulting in DHP production.
• 17β-hydroxysteroid dehydrogenase type 12-like is associated with maturation-inducing steroid synthesis during induced oocyte maturation and ovulation in sturgeons
  Yuya Hasegawa; Shigeho Ijiri; Ryohei Surugaya; Ryuichi Sakai; Shinji Adachi
  Aquaculture, 546, 737238, 737238, Elsevier {BV}, Jan. 2022, [Peer-reviewed]
  English, Scientific journal

• 排卵能とは何か？ ーチョウザメ類の排卵機構解明に向けた研究からー
  駿河谷諒平
  令和7年度日本動物学会中部支部大会, 06 Dec. 2025, Public discourse
  06 Dec. 2025 - 07 Dec. 2025, 公開シンポジウム「生殖細胞形成の仕組みー魚類の研究から解ったこと」, [Invited]
• TRANSCRIPTIONAL REGULATION OF PROSTAGLANDIN SYNTHESIS-RELATED GENES VIA WNT/Β-CATENIN SIGNALING DURING OVULATORY COMPETENCE INDUCTION IN OVARIAN FOLLICLES OF STURGEONS
  Ryohei Surugaya; Kazuki Tousaka; Chika Fujimori; Atsushi P. Kimura; Josei Sato; Koji Ishiya; Tomohiro Tamura; Katsumasa Yamashita; Kiyoshi Hiraoka; Shintaro Niwa; Shinji Adachi; Shigeho Ijiri
  The 19th International Congress of Comparative Endocrinology, 09 Jul. 2025, English, Poster presentation
  08 Jul. 2025 - 12 Jul. 2025
• 排卵期のチョウザメ類卵濾胞におけるプロテアーゼ遺伝子群の発現プロファイル
  駿河谷諒平; 長谷川祐也; 東坂和樹; 足立伸次; 井尻成保
  令和7年度日本水産学会春季大会, 27 Mar. 2025
  26 Mar. 2025 - 29 Mar. 2025
• チョウザメ類の良質卵および不良卵における母性mRNA量の発現量比較
  駿河谷諒平; 中野玖里子; 東坂和樹; 足立伸次; 井尻成保
  日本水産増殖学会 第22回大会, 29 Nov. 2024, Japanese, Poster presentation
  29 Nov. 2024 - 30 Nov. 2024
• アムールチョウザメにおける排卵誘導適期推定の分子マーカーの同定
  駿河谷諒平; 東坂和樹; 足立伸次; 井尻成保
  日本水産増殖学会 第22回大会, 29 Nov. 2024, Japanese, Oral presentation
  29 Nov. 2024 - 30 Nov. 2024
• アムールチョウザメ卵濾胞におけるプロスタグランジン合成酵素ptgs2aの転写を制御するWnt-responsive elementの特定
  駿河谷諒平; 藤森千加; 木村敦; 佐藤丈生; 東坂和樹; 石谷孔司; 田村具博; 足立伸次; 井尻成保
  第48回日本比較内分泌学会大会及びシンポジウム函館大会, 30 Aug. 2024, Japanese, Poster presentation
  29 Aug. 2024 - 01 Sep. 2024
• 排卵期におけるアムールチョウザメ2種のptgs2の発現動態と転写調節機構
  駿河谷諒平; 東坂和樹; 足立伸次; 井尻成保
  第47回日本比較内分泌学会大会及びシンポジウム, 18 Nov. 2023, Japanese, Poster presentation
  17 Nov. 2023 - 19 Nov. 2023, [Domestic Conference]
• Induction of ptgs2a and ptger3 expression in ovarian follicles is essential for ovulation in Amur sturgeon (Acipenser schrenckii)
  Ryohei Surugaya; Yuya Hasegawa; Kazuki Tosaka; Shigeho Ijiri; Shinji Adachi
  12th International Symposium on Reproductive Physiology of Fish, 18 May 2023, English, Poster presentation
  15 May 2023 - 19 May 2023, [International presentation]
• アムールチョウザメ卵濾胞における2タイプのPG合成酵素ptgs2とPG受容体ep3の発現動態
  駿河谷諒平; 足立伸次; 井尻成保
  令和5年度日本水産学会春季大会, 29 Mar. 2023, Japanese, Oral presentation
  28 Mar. 2023 - 31 Mar. 2023, [Domestic Conference]
• アムールチョウザメ卵濾胞における排卵能獲得中に発現する遺伝子の探索
  駿河谷諒平; 足立伸次; 井尻成保
  第46回日本比較内分泌学会大会及びシンポジウム, 29 Oct. 2022, Japanese, Oral presentation
  28 Oct. 2022 - 30 Oct. 2022, [Domestic Conference]
• Expression pattern of ovulation-related genes in the ovarian follicles of the Amur sturgeon (Acipenser schrenckii) during ovulation.
  Ryohei Surugaya; Shigeho Ijiri; Shinji Adachi
  The 6th International Exchange Seminar of Zoology, 17 Sep. 2022, English, Oral presentation
  17 Sep. 2022 - 17 Sep. 2022, [International presentation]
• アムールチョウザメの排卵に関わるプロテアーゼ遺伝子の探索
  駿河谷諒平; 井尻成保; 足立伸次
  令和3年度日本水産学会春季大会, 27 Mar. 2021, Japanese, Oral presentation
  26 Mar. 2021 - 30 Mar. 2021, [Domestic Conference]
• アムールチョウザメの排卵関連遺伝子の探索
  駿河谷諒平; 井尻成保; 足立伸次
  令和2年度日本水産学会北海道支部大会, 05 Dec. 2020, Japanese, Oral presentation
  05 Dec. 2020 - 05 Dec. 2020, [Domestic Conference]
• アムールチョウザメ (Acipenser schrenckii) 卵濾胞における排卵能獲得の分子機構解析
  駿河谷諒平; 井尻成保; 足立伸次
  第44回日本比較内分泌学会大会及びシンポジウム, 08 Nov. 2019, Japanese, Oral presentation
  08 Nov. 2019 - 10 Nov. 2019, [Domestic Conference]
• アムールチョウザメ卵濾胞の外観と排卵の関係
  駿河谷諒平; 井尻成保; 足立伸次
  令和元年度日本水産学会北海道支部大会, 02 Nov. 2019, Japanese, Oral presentation
  02 Nov. 2019 - 03 Nov. 2019, [Domestic Conference]
• アムールチョウザメ卵濾胞における排卵能獲得時の遺伝子発現動態
  駿河谷諒平; 井尻成保; 足立伸次
  令和元年度日本水産学会秋季大会, 10 Sep. 2019, Japanese, Oral presentation
  08 Sep. 2019 - 10 Sep. 2019, Japan, [Domestic Conference]
• アムールチョウザメ卵濾胞における排卵能関連遺伝子の発現動態
  駿河谷諒平; 井尻成保; 足立伸次
  平成31年度日本水産学会春季大会, 27 Mar. 2019, Japanese, Poster presentation
  26 Mar. 2019 - 29 Mar. 2019, [Domestic Conference]

• Nov. 2019 - Present
  The Japan Society for Comparative Endocrinology
• Mar. 2019 - Present
  The Japanese Society of Fisheries Science

• チョウザメの排卵能獲得を司るプロスタグランジン合成酵素遺伝子の転写調節機構解明
  科学研究費助成事業
  01 Apr. 2026 - 31 Mar. 2028
  駿河谷 諒平
  日本学術振興会, 若手研究, 北海道大学, 26K18130
• チョウザメ類の排卵卵を用いた高品質キャビアの開発
  研究助成金
  Oct. 2025 - Sep. 2026
  駿河谷 諒平; 足立 伸次; 井尻 成保
  公益財団法人戸部眞紀財団, 北海道大学, Principal investigator, 25-JE-005
• チョウザメの安定種苗生産実現に向けたプロスタグランジン合成制御機構の解明
  第11回北海道大学部局横断シンポジウム研究助成（金賞）
  Oct. 2025 - Mar. 2026
  駿河谷 諒平; 藤森 千加
  北海道大学, Principal investigator
• 特殊系統サクラマスによるイクラ・魚肉ダブル収益型養殖の確立
  イノベーション創出研究支援事業 産学連携創出補助金
  Aug. 2025 - Mar. 2026
  萩原 聖士; 駿河谷 諒平; 佐々木 理; 菊地 優
  ノーステック財団, Coinvestigator, S-3-6
• ニホンウナギの卵質改善に向けた採卵適期推定の分子指標の同定
  助成事業
  Apr. 2025 - Mar. 2026
  駿河谷 諒平
  公益財団法人南北海道学術振興財団, 北海道大学, Principal investigator
• チョウザメ卵濾胞における排卵能獲得を誘起するWntシグナル活性化メカニズムの解明
  科学研究費助成事業
  Jul. 2024 - Mar. 2026
  駿河谷 諒平
  日本学術振興会, 研究活動スタート支援, 北海道大学, Principal investigator, 24K23140