Researcher basic information

• 博士（理学）, 筑波大学

• https://researchmap.jp/yu-tak?lang=en

• https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201401022189049147

• 201401022189049147

• photoinduced electron transfer
• perovskite nanocrystals
• Carbon nanohorns
• semiconductor quantum dots
• fullerenes (endohedral)
• carbon nanotubes
• phototherapy
• photophysical chemistry
• photofunctional molecules

• Life Science, Bioorganic chemistry
• Nanotechnology/Materials, Structural organic chemistry and physical organic chemistry
• Nanotechnology/Materials, Functional solid state chemistry
• Nanotechnology/Materials, Nanomaterials
• Nanotechnology/Materials, Bio chemistry

• Master's degree program, Graduate School of Environmental Science
• Doctoral (PhD) degree program, Graduate School of Environmental Science

Research activity information

• Mar. 2022, 日本化学会北海道支部, 日本化学会北海道支部奨励賞
• Oct. 2016, フラーレン・ナノチューブ・グラフェン学会, 第13回大澤賞
  髙野 勇太
• Aug. 2011, 日本化学会第4回関東支部大会, 優秀講演賞
  髙野 勇太

• Localized heat induces ERK activation and signal propagation in solid tumors.
  Farsai Taemaitree; Yuta Takano; Daisuke Yamaguchi; Kazushi Yamaguchi; Yudai Yamashita; Motosuke Tsutsumi; Chentao Wen; Kohei Otomo; Kenji Hirai; James Hutchison; Indra Van Zundert; Sandra Krzyzowska; Maria Bravo; Sayuki Hirano; Koutarou D Kimura; Kazuhiro Aoki; Susana Rocha; Tomomi Nemoto; Beatrice Fortuni; Hiroshi Uji-I
  Scientific reports, 30 Apr. 2026, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, Localized plasmonic heating by metallic nanoparticles offers a promising strategy to destroy cancer cells through controlled thermal stress. However, how cells sense and respond to microscale temperature variations within complex tissue environments remains unclear. Here, we investigate how plasmon-induced local heating reshapes intercellular signaling and cell fate within tumor spheroids, focusing on the extracellular signal-regulated kinase (ERK) pathway. HeLa spheroids expressing a FRET-based ERK biosensor were subjected to defined photothermal stimuli using gold nanostars as nanoscale heat sources, while ERK activity was tracked with a deep-learning algorithm (3DeeCellTracker). Local heating triggered marked alterations in ERK signaling dynamics compared to spontaneous activity, including changes in activation frequency, timing, and duration. Remarkably, heat-induced ERK activation spread across neighboring cells, revealing thermally mediated intercellular propagation. Quantitative analysis further showed that temperature elevation modulates cell death and division in a power-dependent manner. These results uncover how nanoscale heat generation governs signaling networks and collective cellular behavior, providing a mechanistic framework to understand and optimize heat-based cancer treatment strategies., 51318454;45267481
• Adaptable Blueprint for Non-metal Near-Infrared Organic Photocatalysts by Aromatic Sulfones
  Kazuya Yoshida; Toshiaki Suzuki; Vasudevanpillai Biju; Yuta Takano
  ACS Applied Materials & Interfaces, 17, 3, 4813, 4820, American Chemical Society (ACS), 13 Jan. 2025, [Peer-reviewed], [Last author, Corresponding author]
  Scientific journal
• Exploring photo-excited states of aromatic sulfones for efficient near-infrared-activated photothermal cancer therapy
  Kazuya Yoshida; Toshiaki Suzuki; Yasuko Osakada; Mamoru Fujitsuka; Yukiko Miyatake; Vasudevanpillai Biju; Yuta Takano
  Bulletin of the Chemical Society of Japan, 98, 1, Oxford University Press (OUP), 08 Jan. 2025, [Peer-reviewed], [Last author, Corresponding author]
  Scientific journal, Abstract
  
  Near-infrared light activation enhances phototherapeutic efficacy due to deep-tissue penetration and minimal invasion. While near-infrared-phototherapeutic agents are widely studied, conventional designs often increase molecular size, affecting pharmacokinetics. This study elucidates the photo-excited states of sulfone-containing aromatic compounds as efficient near-infrared-activated photothermal agents for cancer therapy. We synthesized sulfone-rosamine compounds (3 and 4) exhibiting strong optical absorption around 700 nm, attributed to a unique orbital in the LUMO. Compound 4, 35% smaller than conventional near-infrared-dye molecules, such as Cy5.5 (0.86 nm3/molecule), enhances intracellular mobility. Upon photoexcitation, 4 undergoes rapid non-radiative relaxation, resulting in remarkable photothermal effects and photostability. Transient absorption spectroscopy and density functional theory calculations revealed a mechanism involving rapid non-radiative deactivation after illumination, efficiently converting light to heat. The near-infrared-induced photothermal effect effectively killed various cancer cell lines, including HeLa, MDA-MB-231, and PCI-55. This study provides guidelines for designing novel photodrugs with improved intracellular mobility, near-infrared light responsiveness, and photostability, and introduces the advancement of cancer treatment.
• Carbon nanohorn coating on titanium promotes M2 macrophage polarization
  Sadahito KIMURA; Eri HIRATA; Yuta TAKANO; Miho IBI; Natsumi USHIJIMA; Eijiro MIYAKO; Masako YUDASAKA; Yukari MAEDA; Daisuke KONISHI; Kiwamu SAKAGUCHI; Atsuro YOKOYAMA
  Dental Materials Journal, 44, 5, 564, 571, Japanese Society for Dental Materials and Devices, 2025, [Domestic magazines]
  English, Scientific journal, This study investigated the effects of carbon nanohorns (CNHs) coated on titanium surfaces on macrophage responses. The CNHs were electrodeposited on titanium discs to create a uniform coating with a thickness of 0.2-0.3 µm. Analysis of macrophages cultured on CNH-modified titanium (CNH/Ti) revealed decreased production of pro-inflammatory cytokines (TNFα and IL6) and increased IL10 gene expression compared to unmodified titanium. Immunofluorescence analysis showed higher expression of the M2 marker CD206 and lower expression of the M1 marker CD86 on the CNH/Ti surfaces. Gene expression analysis indicated downregulation of genes involved in DNA transcription, repair, and replication, correlating with controlled cell proliferation on CNH/Ti. These findings demonstrate that CNH modification on titanium surfaces influences macrophage cytokine production and phenotype marker expression, suggesting its potential application in dental implant development.
• Near-infrared light-boosted antimicrobial activity of minocycline/hyaluronan/carbon nanohorn composite toward peri-implantitis treatments
  Daisuke Konishi; Eri Hirata; Yuta Takano; Yukari Maeda; Natsumi Ushijima; Masako Yudasaka; Atsuro Yokoyama
  Nanoscale, Royal Society of Chemistry (RSC), Jun. 2024, [Peer-reviewed], [Corresponding author]
  Scientific journal, A near-infrared responsive composite material (MC/HA/CNH) was developed for the treatment of peri-implantitis. The MC/HA/CNH showed enhanced antimicrobial effect by near-infrared light irradiation, which lasted for 48 hours.
• Bio-catalytic nanoparticle shaping for preparing mesoscopic assemblies of semiconductor quantum dots and organic molecules
  Rumana Akter; Nicholas Kirkwood; Samantha Zaman; Bang Lu; Tinci Wang; Satoru Takakusagi; Paul Mulvaney; Vasudevanpillai Biju; Yuta Takano
  Nanoscale Horizons, 9, 7, 1128, 1136, Royal Society of Chemistry (RSC), May 2024, [Peer-reviewed], [Lead author, Last author, Corresponding author]
  English, Scientific journal, Mesoscopic particles are promising materials in various fields owing to the combined or synergistic nature of quantum and bulk effects. We present a new approach for preparing a variety of dispersible mesoscopic particles using bio-enzymes., 51318454
• Investigation of the Nanoparticulation Method and Cell-Killing Effect following the Mitochondrial Delivery of Hydrophobic Porphyrin-Based Photosensitizers
  Naganawa, R.; Zhao, H.; Takano, Y.; Maeki, M.; Tokeshi, M.; Harashima, H.; Yamada, Y.
  International Journal of Molecular Sciences, 25, 8, 12 Apr. 2024, [Peer-reviewed]
  Scientific journal
• Dual-color photoluminescence modulation of zero-dimensional hybrid copper halide microcrystals
  Rahul Ghosh Dastidar; Takuya Okamoto; Kiyonori Takahashi; Yuta Takano; Chakkooth Vijayakumar; Challapalli Subrahmanyam; Vasudevanpillai Biju
  Nanoscale, 16, 10, 5107, 5114, Royal Society of Chemistry (RSC), 2024, [Peer-reviewed]
  Scientific journal, Green–red dual emission in hybrid copper halides is controlled by a conducting surface-induced deactivation of the red-emitting state.
• π-extended porphyrin-based near-infrared photosensitizers for mitochondria-targeted photodynamic therapy
  Hanjun Zhao; Rina Naganawa; Yuma Yamada; Yasuko Osakada; Mamoru Fujitsuka; Hideyuki Mitomo; Yukiko Miyatake; Hideyoshi Harashima; Vasudevanpillai Biju; Yuta Takano
  Journal of Photochemistry and Photobiology A: Chemistry, 115397, 115397, Elsevier BV, Dec. 2023, [Peer-reviewed], [Last author, Corresponding author]
  Scientific journal
• Luminescent quantum dots: Synthesis, optical properties, bioimaging and toxicity.
  Jeladhara Sobhanan; Jose V Rival; Abdulaziz Anas; Edakkattuparambil Sidharth Shibu; Yuta Takano; Vasudevanpillai Biju
  Advanced drug delivery reviews, 197, 114830, 114830, 20 Apr. 2023, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Luminescent nanomaterials such as semiconductor nanocrystals (NCs) and quantum dots (QDs) attract much attention to optical detectors, LEDs, photovoltaics, displays, biosensing, and bioimaging. These materials include metal chalcogenide QDs and metal halide perovskite NCs. Since the introduction of cadmium chalcogenide QDs to biolabeling and bioimaging, various metal nanoparticles (NPs), atomically precise metal nanoclusters, carbon QDs, graphene QDs, silicon QDs, and other chalcogenide QDs have been infiltrating the nano-bio interface as imaging and therapeutic agents. Nanobioconjugates prepared from luminescent QDs form a new class of imaging probes for cellular and in vivo imaging with single-molecule, super-resolution, and 3D resolutions. Surface modified and bioconjugated core-only and core-shell QDs of metal chalcogenides (MX; M = Cd/Pb/Hg/Ag, and X = S/Se/Te,), binary metal chalcogenides (MInX2; M = Cu/Ag, and X = S/Se/Te), indium compounds (InAs and InP), metal NPs (Ag, Au, and Pt), pure or mixed precision nanoclusters (Ag, Au, Pt), carbon nanomaterials (graphene QDs, graphene nanosheets, carbon NPs, and nanodiamond), silica NPs, silicon QDs, etc. have become prevalent in biosensing, bioimaging, and phototherapy. While heavy metal-based QDs are limited to in vitro bioanalysis or clinical testing due to their potential metal ion-induced toxicity, carbon (nanodiamond and graphene) and silicon QDs, gold and silica nanoparticles, and metal nanoclusters continue their in vivo voyage towards clinical imaging and therapeutic applications. This review summarizes the synthesis, chemical modifications, optical properties, and bioimaging applications of semiconductor QDs with particular references to metal chalcogenide QDs and bimetallic chalcogenide QDs. Also, this review highlights the toxicity and pharmacokinetics of QD bioconjugates.
• An antibacterial conjugate of carbon nanohorns for NIR-light mediated peri-implantitis treatment
  Eri Hirata; Yuta Takano; Daisuke Konishi; Yukari Maeda; Natsumi Ushijima; Masako Yudasaka; Atsuro Yokoyama
  Chemical Communications, 59, 73, 11000, 11003, 2023, [Peer-reviewed], [Corresponding author]
  Scientific journal
• Excitation‐Wavelength‐dependent Functionalities of Temporally‐controlled Sensing and Generation of Singlet Oxygen by a Photoexcited State Engineered Rhodamine 6G‐anthracene Conjugate
  Hanjun Zhao; Yuta Takano; Devika Sasikumar; Yukiko Miyatake; Vasudevanpillai Biju
  Chemistry – A European Journal, 12 Oct. 2022, [Peer-reviewed], [Lead author, Corresponding author]
  Scientific journal
• Fine-tuning the encapsulation of a photosensitizer in nanoparticles reveals the relationship between internal structure and phototherapeutic effects.
  Fumika Kubota; Satrialdi; Yuta Takano; Masatoshi Maeki; Manabu Tokeshi; Hideyoshi Harashima; Yuma Yamada
  Journal of biophotonics, 16, 3, e202200119, 01 Sep. 2022, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal, Photodynamic therapy (PDT) is a cancer therapy that uses a photosensitizer (PS) in the presence of oxygen molecules. Since singlet oxygen is highly reactive, it is important to deliver it to the target site. Thus, an efficient drug delivery system (DDS) is essential for enhancing the efficacy of such a treatment and protecting against the side effects of PDT. Here, we report on attempts to increase the therapeutic effect of PDT by using a DDS, a lipid nanoparticle (LNP). We prepared a porphyrin analog, rTPA (PS) that was encapsulated in LNPs using a microfluidic device. The findings indicated that the internal structure of the prepared particles changed depending on the amount of rTPA in LNPs. The photoactivity and cell-killing effect of PS in LNPs also changed when the amount of the cargo increased. These results suggest that the internal structure of LNPs is important factors that affect drug efficacy. This article is protected by copyright. All rights reserved.
• Caging and photo-triggered uncaging of singlet oxygen by excited state engineering of electron donor–acceptor-linked molecular sensors
  Sasikumar, D.; Takano, Y.; Zhao, H.; Kohara, R.; Hamada, M.; Kobori, Y.; Biju, V.
  Scientific Reports, 12, 1, Springer Science and Business Media LLC, Jul. 2022, [Peer-reviewed], [Corresponding author]
  Scientific journal
• Multimodal CTC detection using stem cell antigen-specific immunosilica particles and immunofluorescent quantum dots
  Jeladhara Sobhanan; Yuta Takano; Sakiko Sugino; Eri Hirata; Shohei Yamamura; Vasudevanpillai Biju
  NPG ASIA MATERIALS, 14, 1, Jan. 2022, [Peer-reviewed]
  English, Scientific journal
• Li@C-60 thin films: characterization and nonlinear optical properties
  Mathias Wolf; Shuichi Toyouchi; Peter Walke; Kazuki Umemoto; Akito Masuhara; Hiroshi Fukumura; Yuta Takano; Michio Yamada; Kenji Hirai; Eduard Fron; Hiroshi Uji-i
  RSC ADVANCES, 12, 1, 389, 394, Dec. 2021, [Peer-reviewed]
  English, Scientific journal
• Long-Range Interfacial Charge Carrier Trapping in Halide Perovskite-C60 and Halide Perovskite-TiO2 Donor–Acceptor Films
  Bhagyashree Mahesha Sachith; Takuya Okamoto; Sushant Ghimire; Tomokazu Umeyama; Yuta Takano; Hiroshi Imahori; Vasudevanpillai Biju
  The Journal of Physical Chemistry Letters, 12, 35, 8644, 8651, 09 Sep. 2021, [Peer-reviewed], [Corresponding author]
  English, Scientific journal
• Real-Time Blinking Suppression of Perovskite Quantum Dots by Halide Vacancy Filling
  Lata Chouhan; Syoji Ito; Elizabeth Mariam Thomas; Yuta Takano; Sushant Ghimire; Hiroshi Miyasaka; Vasudevanpillai Biju
  ACS Nano, 15, 2, 2831, 2838, 23 Feb. 2021, [Peer-reviewed]
  English, Scientific journal
• Molecular recognition in the infection, replication, and transmission of COVID-19-causing SARS-CoV-2: an emerging interface of infectious disease, biological chemistry, and nanoscience
  Prem Kumar; Jeladhara Sobhanan; Yuta Takano; Vasudevanpillai Biju
  NPG Asia Materials, 13, 1, Feb. 2021, [Peer-reviewed]
  English, Scientific journal
• An effective in vivo mitochondria-targeting nanocarrier combined with a π-extended porphyrin-type photosensitizer
  Satrialdi; Yuta Takano; Eri Hirata; Natsumi Ushijima; Hideyoshi Harashima; Yuma Yamada
  Nanoscale Advances, 3, 20, 5919, 5927, 2021, [Peer-reviewed], [Corresponding author]
  English, Scientific journal
• Carbon nanohorn coating by electrodeposition accelerate bone formation on titanium implant
  Sari Takada; Eri Hirata; Masatoshi Sakairi; Eijiro Miyako; Yuta Takano; Natsumi Ushijima; Masako Yudasaka; Sumio Iijima; Atsuro Yokoyama
  Artificial Cells, Nanomedicine, and Biotechnology, 49, 1, 20, 29, 01 Jan. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Erratum: Blinking suppression in highly excited CdSe/ZnS quantum dots by electron transfer under large positive gibbs (free) energy change (ACS Nano (2018) 12:9 (9060-9069) DOI: 10.1021/acsnano.8b03010)
  Thomas, E.M.; Ghimire, S.; Kohara, R.; Anil, A.N.; Yuyama, K.-I.; Takano, Y.; George Thomas, K.; Biju, V.
  ACS Nano, 14, 10, 14250, 14250, American Chemical Society ({ACS}), 27 Oct. 2020
  Scientific journal
• Near-infrared light control of membrane potential by an electron donor–acceptor linked molecule
  Yuta Takano; Kazuaki Miyake; Jeladhara Sobhanan; Vasudevanpillai Biju; Nikolai V. Tkachenko; Hiroshi Imahori
  Chemical Communications, 56, 83, 12562, 12565, Royal Society of Chemistry ({RSC}), Sep. 2020, [Peer-reviewed], [Lead author, Corresponding author]
  Scientific journal,

  (π-Extended porphyrin)–fullerene linked molecules are synthesized to utilize the molecular excited states induced by near-infrared light. One of the molecules successfully alters the membrane potential.

• Stable aqueous dispersions of carbon nanohorns loaded with minocycline and exhibiting antibacterial activity
  Yukari Maeda; Eri Hirata; Yuta Takano; Norihito Sakaguchi; Natsumi Ushijima; Ayumi Saeki; Sadahito Kimura; Ken-ichiro Shibata; Masako Yudasaka; Atsuro Yokoyama
  CARBON, 166, 36, 45, Sep. 2020, [Peer-reviewed], [Corresponding author]
  English, Scientific journal
• Photoinduced Betaine Generation for Efficient Photothermal Energy Conversion
  Sasikumar, D.; Takano, Y.; Biju, V.
  Chemistry - A European Journal, 26, 9, 2060, 2066, Wiley, 11 Feb. 2020, [Peer-reviewed], [Corresponding author]
  English, Scientific journal
• Nonradiative Energy Transfer through Distributed Bands in Piezochemically Synthesized Cesium and Formamidinium Lead Halide Perovskites
  Sankaramangalam Balachandran Bhagyalakshmi; Sushant Ghimire; Kiyonari Takahashi; Ken-ichi Yuyama; Yuta Takano; Takayoshi Nakamura; Vasudevanpillai Biju
  CHEMISTRY-A EUROPEAN JOURNAL, 26, 10, 2133, 2137, Feb. 2020, [Peer-reviewed]
  English, Scientific journal
• Erratum: The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter (Chem. Commun. (2020) 56 (1145–1148) DOI: 10.1039/C9CC08563G)
  Satrialdi; Munechika, R.; Biju, V.; Takano, Y.; Harashima, H.; Yamada, Y.
  Chemical Communications, 56, 45, 6153, 6153, 2020
  Scientific journal
• Toxicity of nanomaterials due to photochemical degradation and the release of heavy metal ions
  Jeladhara Sobhanan; Philip Jones; Reiko Kohara; Sakiko Sugino; Martin Vacha; Challapally Subrahmanyam; Yuta Takano; Fred Lacy; Vasudevanpillai Biju
  Nanoscale, 12, 2020, 22049, 22058, Royal Society of Chemistry ({RSC}), 2020, [Peer-reviewed], [Corresponding author]
  Scientific journal,

  The cytotoxicity and genotoxicity of PbS quantum dots by photochemical etching and the release of lead ions.

• Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress
  Yuma Yamada; Yuta Takano; Satrialdi; Jiro Abe; Mitsue Hibino; Hideyoshi Harashima
  BIOMOLECULES, 10, 1, Jan. 2020, [Peer-reviewed], [International Magazine]
  English
• The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter
  Satrialdi; Reina Munechika; Vasudevanpillai Biju; Yuta Takano; Hideyoshi Harashima; Yuma Yamada
  Chemical Communications, 56, 7, 1145, 1148, Royal Society of Chemistry ({RSC}), 2020, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal, The uncontrolled production of reactive oxygen species during photodynamic therapy (PDT) induces oxidative stress. The full potential of PDT is accomplished by delivery of a pi-extended porphyrin-type photosensitizer into mitochondria of tumor cells using a MITO-Porter, a mitochondrial targeting nanodevice. This strategy can be implemented for innovative cancer therapy.
• Exclusive occurrence of photoinduced energy transfer and switching of its direction by rectangular π-extension of nanographenes
  Tomokazu Umeyama; Takuma Hanaoka; Hiroki Yamada; Yuki Namura; Satoshi Mizuno; Tomoya Ohara; Jinseok Baek; JaeHong Park; Yuta Takano; Kati Stranius; Nikolai V. Tkachenko; Hiroshi Imahori
  Chemical Science, 10, 27, 6642, 6650, Royal Society of Chemistry ({RSC}), Jun. 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal, As structure defined cutouts of the graphene lattice, nanographene molecules have gained plenty of attention because of their high potential for versatile applications in organic electronics and energy conversion devices and as ideal model systems for the better understanding of intrinsic structure-property correlations of graphenes. In this study, well-defined nanographenes with sp2 carbon networks of different sizes, hexa-peri-hexabenzocoronene (HBC) and its rectangularly π-extended version, a short graphene nanoribbon (GNR), have been covalently functionalized with photoactive porphyrin molecules. On the basis of their spectroscopic studies, the photodynamics of the porphyrin-linked nanographenes was found to be influenced substantially by the size of the nanographenes. Photoexcitation of the porphyrin-HBC linked system led to exclusive energy transfer (EnT) from the first singlet excited state (S1) of the nanographene to the porphyrin, whereas opposite selective EnT occurred from the first and second singlet excited states (S1 and S2) of the porphyrin to the nanographene in the porphyrin-GNR linked system. In particular, ultrafast efficient EnTs from both the S2 and S1 states of the porphyrin to GNR mimic the corresponding ultrafast EnTs from the S2 and S1 states of carotenoids to chlorophylls in light-harvesting systems of natural photosynthesis. Such unique photophysical properties will be useful for the rational design of carbon-based photofunctional nanomaterials for optoelectronics and solar energy conversion devices.
• Photon-recycling by Energy Transfer in Piezochemically Synthesized and Close-packed Methyl Ammonium Lead Halide Perovskites
  Sushant Ghimire; Kiyonori Takahashi; Yuta Takano; Takayoshi Nakamura; Vasudevanpillai Biju
  Journal of Physical Chemistry C, 123, 45, 27752, 27758, 2019, [Peer-reviewed]
  English, Scientific journal
• Amplified and Multicolor Emission from Films and Interfacial Layers of Lead Halide Perovskite Nanocrystals
  Sushant Ghimire; Lata Chouhan; Yuta Takano; Kiyonori Takahashi; Takayoshi Nakamura; Ken-ichi Yuyama; Vasudevanpillai Biju
  ACS Energy Letters, 4, 1, 133, 141, Jan. 2019, [Peer-reviewed]
  English, Scientific journal
• Kinetics of singlet oxygen sensing using 9-substituted anthracene derivatives
  Devika Sasikumar; Reiko Kohara; Yuta Takano; Ken-ichi Yuyama; Vasudevanpillai Biju
  Journal of Chemical Science, 131, 5, Springer Science and Business Media LLC, Jan. 2019, [Peer-reviewed], [Corresponding author]
  English, Scientific journal
• Blinking Suppression in Highly Excited CdSe/ZnS Quantum Dots by Electron Transfer under Large Positive Gibbs (Free) Energy Change
  Elizabeth Mariam Thomas; Sushant Ghimire; Reiko Kohara; Ajith Nair Anil; Ken-ichi Yuyama; Yuta Takano; K George Thomas; Vasudevan Pillai Biju
  ACS Nano, 12, 9, 9060, 9069, American Chemical Society ({ACS}), Aug. 2018, [Peer-reviewed]
  Scientific journal
• Anisotropic magnetic properties of an endohedral metallofullerene for molecular location sensing
  Yuta Takano; Ryo Tashita; Mitsuaki Suzuki; Hiroshi Imahori; Takeshi Akasaka
  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 256, 535, ORGN, AMER CHEMICAL SOC, Aug. 2018, [Peer-reviewed]
  English, Scientific journal
• Quantum dot–polymer conjugates for stable luminescent displays
  Sushant Ghimire; Anjaly Sivadas; Ken-ichi Yuyama; Yuta Takano; Raju Francis; Vasudevanpillai Biju
  Nanoscale, 10, 28, 13368, 13374, Royal Society of Chemistry ({RSC}), Apr. 2018, [Peer-reviewed]
  Scientific journal,

  The broad absorption of light in the UV-Vis-NIR region and the size-based tunable photoluminescence color of semiconductor quantum dots make these tiny crystals one of the most attractive antennae in solar cells and phosphors in electrooptical devices.

• Photoinduced electron transfer reaction in mitochondria for spatiotemporal selective photo-oxidation of lipids by donor/acceptor linked molecules
  Yuta Takano; Erina Hanai; Hiroshi Imahori
  NANOSCALE, 9, 45, 17909, 17913, Dec. 2017, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Optical control of mitochondrial reductive reactions in living cells using an electron donor-acceptor linked molecule
  Yuta Takano; Reina Munechika; Vasudevanpillai Biju; Hideyoshi Harashima; Hiroshi Imahori; Yuma Yamada
  NANOSCALE, 9, 47, 18690, 18698, Dec. 2017, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Strategy to Attain Remarkably High Photoinduced Charge-Separation Yield of Donor-Acceptor Linked Molecules in Biological Environment via Modulating Their Cationic Moieties
  Ning Cai; Yuta Takano; Tomohiro Numata; Ryuji Inoue; Yasuo Mori; Tatsuya Murakami; Hiroshi Imahori
  JOURNAL OF PHYSICAL CHEMISTRY C, 121, 32, 17457, 17465, Aug. 2017, [Peer-reviewed]
  English, Scientific journal
• The Unanticipated Dimerization of Ce@C-2v(9)-C-82 upon Co-crystallization with Ni(octaethylporphyrin) and Comparison with Monomeric M@C-2v(9)-C-82 (M = La, Sc, and Y)
  Mitsuaki Suzuki; Michio Yamada; Yutaka Maeda; Satoru Sato; Yuta Takano; Filip Uhlik; Zdenek Slanina; Yongfu Lian; Xing Lu; Shigeru Nagase; Marilyn M. Olmstead; Alan L. Balch; Takeshi Akasaka
  CHEMISTRY-A EUROPEAN JOURNAL, 22, 50, 18115, 18122, Dec. 2016, [Peer-reviewed]
  English, Scientific journal
• Molecular Location Sensing Approach by Anisotropic Magnetism of an Endohedral Metallofullerene
  Yuta Takano; Ryo Tashita; Mitsuaki Suzuki; Shigeru Nagase; Hiroshi Imahori; Takeshi Akasaka
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 138, 25, 8000, 8006, Jun. 2016, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Optical control of neuronal firing via photoinduced electron transfer in donor-acceptor conjugates
  Yuta Takano; Tomohiro Numata; Kazuto Fujishima; Kazuaki Miyake; Kazuya Nakao; Wesley David Grove; Ryuji Inoue; Mineko Kengaku; Shigeyoshi Sakaki; Yasuo Mori; Tatsuya Murakami; Hiroshi Imahori
  CHEMICAL SCIENCE, 7, 5, 3331, 3337, 2016, [Peer-reviewed], [Lead author]
  English, Scientific journal
• Endohedral Metallofullerenes: From Chemical Reactivity to Material Performance
  Michio Yamada; Satoru Sato; Yuta Takano; Lai Feng; Shigeru Nagase; Takeshi Akasaka
  Chemical Science of Electron Systems, 133, 153, Springer Japan, 01 Jan. 2015, [Peer-reviewed]
  English, In book
• Unprecedented Chemical Reactivity of a Paramagnetic Endohedral Metallofullerene La@C-5-C-82 that Leads Hydrogen Addition in the 1,3-Dipolar Cycloaddition Reaction
  Yuta Takano; Zdenek Slanina; Jaime Mateos; Takayoshi Tsuchiya; Hirold Kurihara; Filip Uhlik; Maria Angeles Herranz; Nazario Martin; Shigeru Nagase; Takeshi Akasaka
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136, 50, 17537, 17546, Dec. 2014, [Peer-reviewed]
  English, Scientific journal
• Thermodynamically stable [4+2] cycloadducts of lanthanum-encapsulated endohedral metallofullerenes
  Yuta Takano; Yuki Nagashima; M. Angeles Herranz; Nazario Martin; Takeshi Akasaka
  BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 10, 714, 721, Mar. 2014, [Peer-reviewed]
  English, Scientific journal
• Intramolecular Electron Transfers in Donor/Acceptor Linked Molecules Based on Endohedral Lanthanide Metallofullerenes
  Yuta Takano
  FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES, 22, 1-3, 243, 249, Jan. 2014, [Peer-reviewed]
  English, Scientific journal
• Slow Charge Recombination and Enhanced Photoelectrochemical Properties of Diazaporphyrin-Fullerene Linked Dyad
  Masanori Yamamoto; Yuta Takano; Yoshihiro Matano; Kati Stranius; Nikolai V. Tkachenko; Helge Lemmetyinen; Hiroshi Imahori
  JOURNAL OF PHYSICAL CHEMISTRY C, 118, 4, 1808, 1820, Jan. 2014, [Peer-reviewed]
  English, Scientific journal
• Rates and energetics of intramolecular electron transfer processes in conjugated metallofullerenes
  Christina Schubert; Marc Rudolf; Dirk M. Guldi; Yuta Takano; Naomi Mizorogi; M. Ángeles Herranz; Nazario Martín; Shigeru Nagase; Takeshi Akasaka
  Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 371, 1998, Royal Society, 13 Sep. 2013, [Peer-reviewed]
  English, Scientific journal
• New Vistas in Fullerene Chemistry: Organosulfur Compounds Expand the Performance Of Carbon Nanomaterials
  Takeshi Akasaka; Takahiro Tsuchiya; Lai Feng; Yuta Takano; Shigeru Nagase
  PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 188, 4, 317, 321, Apr. 2013, [Peer-reviewed]
  English, Scientific journal
• FUNDAMENTAL AND APPLIED ASPECTS OF ENDOHEDRAL METALLOFULLERENES AS PROMISING CARBON NANOMATERIALS
  Yamada, Michio; Lu, Xing; Feng, Lai; Sato, Satoru; Takano, Yuta; Nagase, Shigeru; Akasaka, Takeshi
  Organic Nanomaterials: Synthesis, Characterization, and Device Applications, 2013
  Scientific journal
• Electrochemical and magnetic properties of a surface-grafted novel endohedral metallofullerene derivative
  Nuria Crivillers; Yuta Takano; Yuya Matsumoto; Javier Casado-Montenegro; Marta Mas-Torrent; Concepcio Rovira; Takeshi Akasaka; Jaume Veciana
  CHEMICAL COMMUNICATIONS, 49, 74, 8145, 8147, 2013, [Peer-reviewed]
  English, Scientific journal
• Intramolecular versus intermolecular electronic interactions between [5,6]-open and [6,6]-closed C-60 adducts with exTTF
  Yuta Takano; Christina Schubert; Naomi Mizorogi; Lai Feng; Azusa Iwano; Mikimasa Katayama; M. Angeles Herranz; Dirk M. Guldi; Nazario Martin; Shigeru Nagase; Takeshi Akasaka
  CHEMICAL SCIENCE, 4, 8, 3166, 3171, 2013, [Peer-reviewed]
  English, Scientific journal
• An Endohedral Metallofullerene as a Pure Electron Donor: Intramolecular Electron Transfer in Donor Acceptor Conjugates of La-2@C-80 and 11,11,12,12-Tetracyano-9,10-anthra-p-quinodimethane (TCAQ)
  Yuta Takano; Shota Obuchi; Naomi Mizorogi; Raul Garcia; M. Angeles Herranz; Marc Rudolf; Dirk M. Guldi; Nazario Martin; Shigeru Nagase; Takeshi Akasaka
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134, 47, 19401, 19408, Nov. 2012, [Peer-reviewed]
  English, Scientific journal
• Stabilizing Ion and Radical Ion Pair States in a Paramagnetic Endohedral Metallofullerene/pi-Extended Tetrathiafulvalene Conjugate
  Yuta Takano; Shota Obuchi; Naomi Mizorogi; Raul Garcia; M. Angeles Herranz; Marc Rudolf; Silke Wolfrum; Dirk M. Guldi; Nazario Martin; Shigeru Nagase; Takeshi Akasaka
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134, 39, 16103, 16106, Oct. 2012, [Peer-reviewed]
  English, Scientific journal
• Utilization of Photoinduced Charge-Separated State of Donor-Acceptor-Linked Molecules for Regulation of Cell Membrane Potential and Ion Transport
  Tomohiro Numata; Tatsuya Murakami; Fumiaki Kawashima; Nobuhiro Morone; John E. Heuser; Yuta Takano; Kei Ohkubo; Shunichi Fukuzumi; Yasuo Mori; Hiroshi Imahori
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134, 14, 6092, 6095, Apr. 2012, [Peer-reviewed]
  English, Scientific journal
• Dearomatizing conversion of pyrazines to 1,4-dihydropyrazine derivatives via transition-metal-free diboration, silaboration, and hydroboration
  Oshima, K.; Ohmura, T.; Suginome, M.; Takano, Y.; Umeyama, T.; Imahori, H.
  Chemical Communications, 48, 68, 2012
  Scientific journal
• Effects of dihydronaphthyl-based [60]fullerene bisadduct regioisomers on polymer solar cell performance
  Shinji Kitaura; Kei Kurotobi; Maki Sato; Yuta Takano; Tomokazu Umeyama; Hiroshi Imahori
  CHEMICAL COMMUNICATIONS, 48, 68, 8550, 8552, 2012, [Peer-reviewed]
  English, Scientific journal
• Self-assembling porphyrins and phthalocyanines for photoinduced charge separation and charge transport
  Hiroshi Imahori; Tomokazu Umeyama; Kei Kurotobi; Yuta Takano
  CHEMICAL COMMUNICATIONS, 48, 34, 4032, 4045, 2012, [Peer-reviewed]
  English, Scientific journal
• Enantioselective Synthesis of Endohedral Metallofullerenes
  Koji Sawai; Yuta Takano; Marta Izquierdo; Salvatore Filippone; Nazario Martin; Zdenek Slanina; Naomi Mizorogi; Markus Waelchli; Takahiro Tsuchiya; Takeshi Akasaka; Shigeru Nagase
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133, 44, 17746, 17752, Nov. 2011, [Peer-reviewed]
  English, Scientific journal
• Reversible radical coupling reaction of paramagnetic endohedral metallofullerenes
  Takano Yuta; Ishitsuka O. Midori; Slanina Zdenek; Tsuchiya Takahiro; Akasaka Takeshi; Kato Tatsuhisa; Nagase Shigeru
  Abstracts of Symposium on Physical Organic Chemistry, 2011, 178, 178, The Society of Physical Organic Chemistry, Japan, 2011
  Japanese, The radical coupling reaction of a paramagnetic endohedral metallofullerene, La@C₈₂, affords mono-substituted La@C₈₂ regioselectively. Four regioisomers of La@C₈₂CH₂C₆H₅ obtained from the reaction with benzyl radical, and were characterized by spectroscopic methods. In addition, heating the La@C₈₂ derivatives in the presence of a radical trapping reagent affords pristine La@C₈₂ in high yield.
• Synthesis and characterization of electron donor-acceptor conjugates based on La₂@C₈₀ and tetracyanoanthraquinodimethane
  Obuchi Shota; Takano Yuta; Mizorogi Naomi; Tsuchiya Takahiro; Akasaka Takeshi; HERRANZ Maria Angeles; MARTIN Nazario; Nagase Shigeru
  Abstracts of Symposium on Physical Organic Chemistry, 2011, 368, 368, The Society of Physical Organic Chemistry, Japan, 2011
  Japanese, We report here the synthesis of a new type of electron donor-acceptor
  conjugates containing endohedral metallofullerene as an electron
  donor,and tetracyanoanthraquinodimethane (TCAQ) as an electron acceptor.
  The target molecule was prepared by 1,3-dipolar cycloaddition of an
  azomethine ylide generated in situ by Prato reaction and isolated by
  HPLC. Characterization using spectroscopic methods and electrochemical
  analysis has been accomplished.
• Current progress on the chemical functionalization and supramolecular chemistry of M@C-82
  Yutaka Maeda; Takahiro Tsuchiya; Xing Lu; Yuta Takano; Takeshi Akasaka; Shigeru Nagase
  NANOSCALE, 3, 6, 2421, 2429, 2011, [Peer-reviewed]
  English, Scientific journal
• ORGANOSULFUR-BASED FULLERENE MATERIALS
  Tsukasa Nakahodo; Midori O. Ishitsuka; Yuta Takano; Takahiro Tsuchiya; Takeshi Akasaka; M. Angeles Herranz; Nazario Martin; Dirk M. Guldi; Shigeru Nagase
  PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 186, 5, 1308, 1311, 2011, [Peer-reviewed]
  English, Scientific journal
• Introduction of Azetidinimine Skeleton on C-60
  Nobuaki Ueda; Hidefumi Nikawa; Yuta Takano; Midori O. Ishitsuka; Takahiro Tsuchiya; Takeshi Akasaka
  HETEROATOM CHEMISTRY, 22, 3-4, 426, 431, 2011, [Peer-reviewed]
  English, Scientific journal
• Donor-Acceptor Conjugates of Lanthanum Endohedral Metallofullerene and pi-Extended Tetrathiafulvalene
  Yuta Takano; M. Angeles Herranz; Nazario Martin; Shankara Gayathri Radhakrishnan; Dirk M. Guldi; Takahiro Tsuchiya; Shigeru Nagase; Takeshi Akasaka
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132, 23, 8048, 8055, Jun. 2010, [Peer-reviewed]
  English, Scientific journal
• Retro-reaction of singly bonded La@C-82 derivatives
  Yuta Takano; Midori O. Ishitsuka; Takahiro Tsuchiya; Takeshi Akasaka; Tatsuhisa Kato; Shigeru Nagase
  CHEMICAL COMMUNICATIONS, 46, 42, 8035, 8036, 2010, [Peer-reviewed]
  English, Scientific journal
• Electron Donor-Acceptor Interactions in Regioselectively Synthesized exTTF(2)-C-70(CF3)(10) Dyads
  Yuta Takano; M. Angeles Herranz; Nazario Martin; Gustavo de Miguel Rojas; Dirk M. Guldi; Ivan E. Kareev; Steven H. Strauss; Olga V. Boltalina; Takahiro Tsuchiya; Takeshi Akasaka
  CHEMISTRY-A EUROPEAN JOURNAL, 16, 18, 5343, 5353, 2010, [Peer-reviewed]
  English, Scientific journal
• Efficient Regioselective [4+2] Cycloaddition of o-Quinodimethane to C-70(CF3)10
  Yuta Takano; M. Angeles Herranz; Ivan E. Kareev; Steven H. Strauss; Olga V. Boltalina; Takeshi Akasaka; Nazario Martin
  JOURNAL OF ORGANIC CHEMISTRY, 74, 17, 6902, 6905, Sep. 2009, [Peer-reviewed]
  English, Scientific journal
• Anisotropic Magnetic Behavior of Anionic Ce@C-82 Carbene Adducts
  Yuta Takano; Motoki Aoyagi; Michio Yamada; Hidefumi Nikawa; Zdenek Slanina; Naomi Mizorogi; Midori O. Ishitsuka; Takahiro Tsuchiya; Yutaka Maeda; Takeshi Akasaka; Tatsuhisa Kato; Shigeru Nagase
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131, 26, 9340, 9346, Jul. 2009, [Peer-reviewed]
  English, Scientific journal
• Synthesis and Anisotropic Magnetic Behavior of Anionic Ce@C₈₂ Carbene Adducts
  TAKANO Yuta; AOYAGI Motoki; YAMADA Michio; NIKAWA Hidefumi; SLANINA Zdenek; MIZOROGI Naomi; ISHITSUKA O. Midori; TSUCHIYA Takahiro; MAEDA Yutaka; AKASAKA Takeshi; KATO Tatsuhisa; NAGASE Shigeru
  Abstracts of Symposium on Physical Organic Chemistry, 2009, 46, 46, The Society of Physical Organic Chemistry, Japan, 2009
  Japanese, Derivatives of Ce@C₈₂ (C_2v) have been synthesized and fully characterized, and their anisotropic magnetism has been observed as paramagnetic shifts in NMR measurements. Carbene addition by photochemical reaction afforded two isomers of Ce@C₈₂(C_2v)Ad (Ad = adamantylidene), 2a and 2b, demonstrating high regioselectivity. The two isomers were characterized using MALDI-TOF mass spectrometry, vis-NIR absorption spectroscopy, ¹H and ¹³C NMR spectroscopy, and electrochemistry. The structure of the minor isomer (2b) was elucidated by single-crystal X-ray structural analysis. ¹³C and ¹H NMR measurements revealed the characteristic anisotropic interaction between the f electron on the Ce atom and nuclear spins of the carbon atoms of the cage and the protons of the Ad group, respectively.
• Radical Coupling Reaction of Paramagnetic Endohedral Metallofullerene La@C-82
  Yuta Takano; Akinori Yomogida; Hidefumi Nikawa; Michio Yamada; Takatsugu Wakahara; Takahiro Tsuchiya; Midori O. Ishitsuka; Yutaka Maeda; Takeshi Akasaka; Tatsuhisa Kato; Zdenek Slanina; Naomi Mizorogi; Shigeru Nagase
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130, 48, 16224, 16230, Dec. 2008, [Peer-reviewed]
  English, Scientific journal
• Simple purification and selective enrichment of metallic SWCNTs produced using the arc-discharge method
  Yutaka Maeda; Yuta Takano; Akiko Sagara; Masahiro Hashimoto; Makoto Kanda; Shin-ichi Kimura; Yongfu Lian; Tsukasa Nakahodo; Takahiro Tsuchiya; Takatsugu Wakahara; Takeshi Akasaka; Tadashi Hasegawa; Said Kazaoui; Nobutsugu Minami; Jing Lu; Shigeru Nagase
  CARBON, 46, 12, 1563, 1569, Oct. 2008, [Peer-reviewed]
  English, Scientific journal
• Radical Coupling Reaction of Paramagnetic Endohedral Metallofullerene La@C₈₂
  Takano Yuta; Yomogida Akinori; Nikawa Hidefumi; Wakahara Takatugu; Tuchiya Takahiro; Oinuma Midori; Maeda Yutaka; Akasaka Takeshi; Kato Tatsuhisa; Slanina Zdenek; Mizorogi Naomi; Nagase Shigeru
  Abstracts of Symposium on Physical Organic Chemistry, 2008, 336, 336, The Society of Physical Organic Chemistry, Japan, 2008
  Japanese, La@C₈₂ is one of the endohedral metallofullerenes which have attracted special attention because they engender new spherical molecules with unique electronic properties. We have found that four isomers of benzyl mono-adducts, La@C₈₂(CH₂C₆H₅), are obtained by the radical coupling reaction in a toluene solution of La@C₈₂. Thermolysis of 3-triphenylmethyloxazolidin-5-one (1) may generate benzyl radical by hydrogen abstraction from toluene, which affords the radical coupling product with La@C₈₂. The same mono-adducts are also obtained by photoirradiation of La@C₈₂ in toluene in the absence of 1. These reactions are applicable to paramagnetic metallofullerenes, such as La@C₈₂ and Ce@C₈₂. Photoirradiation of La@C₈₂ in 1,2-dichlorobenzene in the presence of tetrachlorotoluene also affords the mono-adducts(3a-3d). Single-crystal X-ray structure analysis for 3d reveals its unique structure. Theoretical calculation confirms that the cage carbons having high spin densities are selectively attacked by radical species to form the singly bonded mono-adducts linked by a carbon-carbon single bond.
• Nanorods of endohedral metallofullerene derivative
  Takahiro Tsuchiya; Ryotaro Kumashiro; Katsumi Tanigaki; Yoichiro Matsunaga; Midori O. Ishitsuka; Takatsugu Wakahara; Yutaka Maeda; Yuta Takano; Motoki Aoyagi; Takeshi Akasaka; Michael T. H. Liu; Tatsuhisa Kato; Kazutomo Suenaga; Jong S. Jeong; Sumio Iijima; Fumiko Kimura; Tsunehisa Kimura; Shigeru Nagase
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130, 2, 450, +, Jan. 2008, [Peer-reviewed]
  English, Scientific journal

• Near-Infrared Photosensitizer-Carbon Nanohorn Composites for the Treatment of Periimplantitis
  高野勇太; 平田恵理; 小西大輔; 前田由佳利; 牛島夏未; 湯田坂雅子; 横山敦郎, 日本化学会春季年会講演予稿集(Web), 104th, 2024
• 癌細胞ミトコンドリアを標的とした光感受性物質高含有・高力価のナノカプセルの開発
  木村祐美; 長縄莉奈; 高野勇太; 真栄城正寿; 渡慶次学; 佐藤悠介; 山田勇磨, 生体膜と薬物の相互作用シンポジウム講演要旨集, 45th, 2024
• Dual Emission Modulation of Zero-Dimensional Hybrid Copper Halides
  RAHUL Ghosh Dastidar; OKAMOTO Takuya; TAKAHASHI Kiyonori; TAKANO Yuta; BIJU Vasudevanpillai, 日本化学会春季年会講演予稿集(Web), 104th, 2024
• ロサミン骨格を利用した近赤外光温熱分子の開発
  吉田和矢; ビジュ ヴァスデヴァンピライ; ビジュ ヴァスデヴァンピライ; 高野勇太; 高野勇太, 化学系学協会北海道支部冬季研究発表会(Web), 2023, 2023
• Observation of surface-modified fluorescent beads with dead cell components in 3D-cultured pancreatic cancer cells
  高野勇太; 宮武由甲子; 繁富(栗林)香織; BIJU Vasudevanpillai, 日本化学会春季年会講演予稿集(Web), 103rd, 2023
• 癌光治療用ミトコンドリア標的型ナノカプセルの殺細胞効果向上を目指した試み
  長縄莉奈; 高野勇太; 高野勇太; 趙韓俊; 真栄城正寿; 渡慶次学; 原島秀吉; 山田勇磨, 日本DDS学会学術集会プログラム予稿集, 39th, 2023
• 光治療化合物に向けたスルホンロサミンの分子機能解明
  吉田和矢; 高野勇太; ビジュ ヴァスデヴァンピライ, 化学系学協会北海道支部冬季研究発表会(Web), 2022, 2022
• 光温熱効果がん治療に向けた近赤外光吸収色素分子の開発
  吉田和矢; ビジュ ヴァスデヴァンピライ; ビジュ ヴァスデヴァンピライ; 高野勇太; 高野勇太, 生体膜と薬物の相互作用シンポジウム講演要旨集, 43rd, 2022
• ミトコンドリア標的型DDSを基盤とした癌光治療の検証
  山田勇磨; 窪田文佳; 高野勇太; BIJU Vasudevanpillai; 真栄城正寿; 渡慶次学; 繁富香織; 宮武由甲子; 原島秀吉, 日本DDS学会学術集会プログラム予稿集, 38th, 2022
• ミトコンドリア標的型ナノカプセルを基盤とした癌光治療の検証
  山田勇磨; SATRIALDI; SATRIALDI; 高野勇太; 高野勇太; 原島秀吉, 生体膜と薬物の相互作用シンポジウム講演要旨集, 42nd (CD-ROM), 2021
• ミトコンドリア標的型光線力学的療法を可能とするナノキャリアの構築及び機能評価
  窪田文佳; 山田勇磨; SATRIALDI; 高野勇太; 真栄城正寿; 渡慶次学; 原島秀吉, 生体膜と薬物の相互作用シンポジウム講演要旨集, 42nd (CD-ROM), 2021
• Phototrrigered formation of metastable betaine from 9-substituted acridinium for the efficient photothermal energy conversion
  高野勇太; 高野勇太; SASIKUMAR Devika; BIJU Vasudevanpillai; BIJU Vasudevanpillai, 日本化学会春季年会講演予稿集(CD-ROM), 100th, 2020
• 癌ミトコンドリアを標的とした光線力学療法の検証
  山田勇磨; SATRIALDI; SATRIALDI; 高野勇太; 原島秀吉, 日本酸化ストレス学会学術集会プログラム・抄録集, 73rd, 2020
• Photodynamic therapy for cancer using mitochondrial drug delivery system
  山田勇磨; SATRIALDI; SATRIALDI; 高野勇太; BIJU Vasudevanpillai; 原島秀吉, 日本薬学会年会要旨集(Web), 140th, 2020
• 金属有機構造体（MOF）の光エネルギーのリレーを利用したイメージング
  髙野 勇太, 日本薬学会誌 ファルマシア, 55, 3, 253, 253, Mar. 2019, [Invited]
  Japanese, Introduction scientific journal
• 光増感分子rTPAを搭載したミトコンドリア標的型ナノカプセルの開発および癌光治療戦略の検証
  山田勇磨; SATRI Aldi; 高野勇太; BIJU Vasudevanpillai; 原島秀吉, 日本DDS学会学術集会プログラム予稿集, 35th, 2019
• ミトコンドリア標的型ナノキャリアを用いた癌光治療戦略の検証
  窪田文佳; 山田勇磨; SATRIALDI; SATRIALDI; 高野勇太; BIJU Vasudevanpillai; 原島秀吉, 日本酸化ストレス学会学術集会プログラム・抄録集, 72nd, 2019
• 有機分子の特異な光励起状態を利用したミトコンドリア内酸化・還元反応の誘起
  高野勇太; 高野勇太, 日本酸化ストレス学会学術集会プログラム・抄録集, 72nd, 2019
• π拡張型ポルフィリンとミトコンドリア標的型ドラッグデリバリキャリアを用いた近赤外がん光治療化合物の開発
  高野勇太; SATRIALDI; 宗近玲奈; 原島秀吉; 山田勇磨; BIJU Vasudevanpillai, 光化学討論会要旨集(CD-ROM), 2019, 2019
• 光機能性フラーレンを用いた細胞機能の光制御アプローチ
  髙野 勇太, 生物工学会誌, 95, 12, 705, 707, Dec. 2017, [Invited]
  Japanese, Introduction scientific journal
• 光誘起電荷分離分子からの電子移動反応を利用した癌細胞ミトコンドリア内での光還元反応手法の開発
  高野勇太; 高野勇太; 宗近玲奈; 福田豊; BIJU Vasudevan Pillai; 今堀博; 今堀博; 原島秀吉; 山田勇磨, 光化学討論会要旨集(CD-ROM), 2017, 2017
• 癌細胞ミトコンドリアを標的とした光殺細胞効果の検証
  山田勇磨; 高野勇太; 宗近玲那; 福田豊; 今堀博; 原島秀吉, 日本酸化ストレス学会学術集会プログラム・抄録集, 70th, 2017
• 両親媒性フェロセン-ポルフィリン-フラーレン三元連結型分子の高極性溶媒中における会合体構造と光誘起電荷分離状態の解明
  中尾和也; 高野勇太; 村上達也; 今堀博, 日本化学会講演予稿集, 95th, 4, 2015
• 光熱変換ナノ材料の安全な細胞膜デリバリーと痛み受容体TRPV1の光制御
  中辻博貴; 沼田朋大; 諸根信弘; HEUSER John; 高野勇太; 森泰生; 今堀博; 今堀博; 村上達也, 日本DDS学会学術集会プログラム予稿集, 31st, 2015
• 光誘起電荷分離分子によるカリウムイオンチャネル阻害と細胞膜電位制御
  高野勇太; 沼田朋大; 村上達也; 河島史明; 諸根信弘; HEUSER John E.; 森泰生; 今堀博, 日本化学会講演予稿集, 93rd, 4, 2013
• ドナー・アクセプター連結分子の光電荷分離状態を利用した細胞膜電位とイオン輸送制御
  沼田朋大; 沼田朋大; 村上達也; 河島史明; 諸根信弘; HEUSER John E.; 高野勇太; 森泰生; 森泰生; 今堀博; 今堀博, 生体膜と薬物の相互作用シンポジウム講演要旨集, 34th, 2012
• ラジカル付加反応によるLa@C₈₂の可逆的電子状態制御
  高野勇太; 生沼みどり; SLANINA Zdenek; 赤阪健; 加藤立久; 永瀬茂, 日本化学会講演予稿集, 92nd, 2, 2012
• アゼチジニミン骨格を有するC₆₀誘導体
  上田展彰; 高野勇太; 二川秀文; 石塚みどり; 土屋敬広; 赤阪健, 日本化学会講演予稿集, 91st, 4, 2011
• 光学活性金属内包フラーレン誘導体の合成と性質
  澤井孝治; 高野勇太; FILIPPONE Salvatore; MARTIN Nazario; 生沼みどり; 土屋敬広; 赤阪健, 日本化学会講演予稿集, 91st, 2, 2011
• La@C₈₂のラジカルカップリング反応とその可逆反応
  高野勇太; 生沼みどり; 土屋敬広; SLANINA Zdenek; 赤阪健; 加藤立久; 永瀬茂, 日本化学会講演予稿集, 91st, 2, 2011
• π共役拡張型テトラチアフルバレンと金属内包フラーレンLa₂@C₈₀を鍵物質とするドナー・アクセプター連結型分子の合成と物性解明
  高野勇太; 赤阪健; HERRANZ Maria Angeles; MARTIN Nazario; GULDI Dirk M., 有機典型元素化学討論会講演要旨集, 37th, 2010
• C₆₀とπ共役拡張型テトラチアフルバレンを用いた新規ドナーアクセプター連結型分子の合成と構造解析
  岩野あずさ; FENG Lai; 高野勇太; 溝呂木直美; 土屋敬広; 赤阪健; 永瀬茂; HERRANZ Maria Angeles; MARTIN Nazario, 有機典型元素化学討論会講演要旨集, 37th, 2010
• 金属内包フラーレンとπ共役拡張型テトラチアフルバレンを用いたドナー・アクセプター連結型分子の合成
  高野勇太; HERRANZ M. Angeles; MARTIN Nazario; GULDI Dirk M.; 土屋敬広; 赤阪健, 日本化学会講演予稿集, 90th, 2, 2010
• Radical Coupling Reaction of Paramagnetic Endohedral Metallofullerene La@C₈₂
  高野勇太; 蓬田知行; 二川秀史; 若原孝次; 土屋敬広; 生沼みどり; 前田優; 赤阪健; 加藤立久; SLANINA Zdenek; 溝呂木直美; 永瀬茂, 日本化学会講演予稿集, 89th, 1, 2009
• π共役拡張TTF/C₇₀(CF₃)₁₀ハイブリッド型光機能性分子系の構築
  高野勇太; 生沼みどり; 土屋敬広; 赤阪健; HERRANZ Maria Angeles; MARTIN Nazario; GULDI Dirk; BOLTALINA Olga V., 有機典型元素化学討論会講演要旨集, 35th, 2008
• 常磁性金属内包フラーレン:La@C₈₂におけるラジカルカップリング反応
  高野勇太; 蓬田知行; 二川秀史; 若原孝次; 土屋敬広; 生沼みどり; 前田優; 赤阪健; 加藤立久; SLANINA Zdenek; 溝呂木直美; 永瀬茂, 基礎有機化学討論会要旨集, 19th, 2008
• Radical reaction of La@C₈₂
  高野勇太; 蓬田知行; 若原孝次; 土屋敬広; 仲程司; 前田優; 赤阪健; 加藤立久; 溝呂木直美; 永瀬茂, 日本化学会講演予稿集, 86th, 1, 2006

• Cell-inspired materials and engineering
  Wang, Dan Ohtan; Packwood, Daniel
  Springer, 2021, 9783030559236, viii, 257 p., English
• Chemical Science of pi-Electron Systems Part II. Curved pi-Electron Systems
  M. Yamada; S. Sato; Y. Takano; L. Feng; S. Nagase; T. Akasaka, Endohedral Metallofullerenes: From Chemical Reactivity to Material Performance
  Springer, Berlin, Germany, 2015, [Contributor]
• Organic Nanomaterials -Synthesis, Characterization, and Device Applications-
  M. Yamada; X. Lu; L. Feng; S. Sato; Y. Takano; S. Nagase; T. Akasaka, Fundamental and Applied Aspects of Endohedral Metallofullerenes as Promising Carbon Nanomaterials
  Wiley, London, U.K., 2013, [Contributor]

• Bioenzymatic Nanoparticle Shaping: An Innovative Method for Producing Functional Mesoscopic Particles
  Yuta Takano; Rumana Akter; Nicholas Kirkwood; Samantha Zaman; Bang Lu; Satoru Takakusagi; Paul Mulvaney; Vasudevanpillai Biju
  日本化学会第106春季年会, 19 Mar. 2026, Japanese, Oral presentation
  17 Mar. 2026 - 20 Mar. 2026, 50149774
• Concentration-Responsive Photo-Redox Modulation in Chitosan Platinum(II)-Porphyrin/Chitosan Composite
  Kushal Mohan Gowda; Vasudevanpillai Biju; Yuta Takano
  北海道大学J-PEAKSフォトンフロンティアフォーラム2025, 23 Dec. 2025, English, Poster presentation
  23 Dec. 2025
• Concentration-Dependent Photo-Redox Switching of a Chitosan Supported Platinum(II)-Porphyrin Complex
  Kushal Mohan Gowda; Vasudevanpillai Biju; Yuta Takano
  The 26th RIES-HOKUDAI International Symposium, 26 Nov. 2025, English, Poster presentation
  26 Nov. 2025 - 27 Nov. 2025, 50149774
• Mitochondria-targeted nanocapsules enhance photodynamic therapy efficacy by improving photosensitizer encapsulation
  Yumi Kimura; Yuta Takano; Yusuke Sato; Yuma Yamada
  The 84th Annual Meeting of the Japanese Cancer Association, 26 Sep. 2025, Japanese, Oral presentation
  25 Sep. 2025 - 27 Sep. 2025
• Historical overview of nanocarbon bio-research from Japan
  Yuta Takano
  The 15th Nanocarbon Bio Symposium, 23 Sep. 2025, English, Invited oral presentation
  50149774, [Invited]
• ミノサイクリン-カーボンナノホーン複合体の生体内における光熱効果ならびに生体適合性の評価.
  前田由佳利; 平田恵理; 高野勇太; 小西大輔; 横山敦郎; 坂口究
  第45回日本口腔インプラント学会 東北・北海道支部大会, 06 Sep. 2025, Japanese, Oral presentation
  50149774;46932187
• 癌光治療用ミトコンドリア標的型ナノカプセルにおける光感受性物質の含有量増加に伴う力価向上の検討
  木村祐美; 長縄莉奈; 高野勇太; 真栄城正寿; 渡慶次学; 佐藤悠介; 山田勇磨
  日本薬学会北海道支部第152回例会, 17 May 2025, Japanese
  17 May 2025 - 17 May 2025
• 近赤外光を用いた光機能性化合物開発と循環型材料への展開
  高野 勇太
  J-PEAKS Photon Frontier Kick-off meeting, 10 Apr. 2025, Japanese, Nominated symposium
  [Invited]
• Bio-catalytic Nanoparticle Shaping (BNS): A Novel Method for Synthesizing Diverse Inorganic and Organic Mesoscopic Particles
  Yuta Takano
  2024 International Conference on Advanced Nano-Micro Materials (ICNM2 2024), 06 Dec. 2024, English, Nominated symposium
  32560976;50149774, [Invited]
• Bio-enzymatic Nanoparticle Shaping (BNS) for Preparing Variety of Inorganic and Organic Materials
  Yuta Takano
  2024 RIES-CEFMS Symposium, 28 Nov. 2024, English, Invited oral presentation
  50149774;32560976, [Invited]
• 近赤外光を用いた光機能性化合物開発と循環型材料への展開
  高野 勇太
  光有機化学研究会, 26 Oct. 2024, Japanese, Invited oral presentation
  50149774;46932187;32560976;44545886;32560977, [Invited]
• Organic Molecular Near-Infrared Photocatalyst Based on Sulfone-rosamine
  YOSHIDA, Kazuya; KAWABATA, Toshiyuki; NAKAGAWA, Tatsuo; SUZUKI, Toshiaki; Biju, Vasudevanpillai; TAKANO, Yuta
  2024年光化学討論会, 03 Sep. 2024, English, Oral presentation
• 生体触媒ナノ粒子成形法による量子ドットおよびポルフィリン集合体の作製
  高野 勇太; アクター ルマナ; カークウッド ニコラス; ザーマン サマンサ; ワン ティアンシー; マルヴァニ ポール; ビジュ ヴァスデヴァンピライ
  2024年光化学討論会, 03 Sep. 2024, Japanese, Oral presentation
  46932187;32560976;44545886
• Bio-enzymatic shaping of inorganic and organic nanoparticles
  Yuta Takano
  MULTIDIM SYMPOSIUM -Bi-dimensional carbon materials and beyond: synthesis, properties and biomedical applications-, 15 Jun. 2024, English, Invited oral presentation
  46932187;32560976;44545886;32560977, [Invited]
• Development of High-Performance Mitochondria-Targeted Photocancer Therapeutics Using Innovative 3D Cell Culture Devices
  Yuta TAKANO; Yuma YAMADA; Yukiko MIATAKE; Kaori SHIGETOMI
  第６回北海道大学部局横断シンポジウム, 19 Oct. 2020
  [Invited]
• High efficiency photothermal convirsion of 9-substituted acridinium using photo-induced metastable betaine
  Yuta Takano; Devika Sasikumar; Vasudevvanpillai Biju
  2020年web光化学討論会, 09 Sep. 2020
• Construction of mitochondria-targeted nanocapsules loaded with photosensitizing molecule rTPA and validation of cancer phototherapy strategy using tumor-bearing mouse models
  Yuta YAMADA; Satrialdi; Yuta TAKANO; Vasudevan; Pillai Biju; Hiddesi HARASHIMA
  日本薬学会 第140年会, 25 Mar. 2020, Oral presentation
• High efficiency of photo-thermal conversion using photo-induced metastable betaine of 9-substituted acridinium
  Yuta TAKANO; Sasikumar Devika; Vasudevan; Pillai Biju
  日本化学会第100春季年会, Mar. 2020, Oral presentation
• Delayed Red-Shifted Emission by Energy Transfer-Induced Photon Recycling in Pressed Lead Halide Perovskites
  S. Bhagya Lakshmi; S. Ghimire; Y. Takano; K. Yuyama; V. P. Biju
  2019年光化学討論会, Sep. 2019, English, Oral presentation
  [Domestic Conference]
• The Activated Reaction of Singlet Oxygen Trapped in an Electron Donor-Acceptor Molecular Sensor
  D. Sasikumar; Y. Takano; M. Hamada; K. Yuyama; Y. Kobori; V. P. Biju
  2019年光化学討論会, Sep. 2019, English, Poster presentation
  [Domestic Conference]
• Mitochondrial targeting phototherapy by near-infrared light and pi-extended porphyrin/drug delivery carrier conjugate
  Yuta Takano
  7th International conference for young chemists, 14 Aug. 2019, English, Invited oral presentation
  [Invited], [International presentation]
• 有機分子の特異な光励起状態を利用したミトコンドリア内酸化・還元反応の誘起
  髙野 勇太
  第72回日本酸化ストレス学会, 26 Jun. 2019, Japanese, Invited oral presentation
  [Invited], [Domestic Conference]
• Steady-state Spectroscopic Studies of the Kinetics of Singlet Oxygen Sensing by 9-Substituted Anthracene Derivatives
  D. Sasikumar; Y. Takano; K. Yuyama; V. P. Biju
  日本化学会第99春季年会, Mar. 2019, English, Oral presentation
  [Domestic Conference]
• Conjugate of pi-extended porphyrin/drug delivery carrier for near-infrared cancer phototherapy
  Yuta Takano; Satrialdi; Reina Munechika; Hideyoshi Harashima; Yuma Yamada; Vasudevan Pillai Biju
  日本化学会第99春季年会, Mar. 2019, English, Oral presentation
  [Domestic Conference]
• Anisotropic magnetic properties of an endohedral metallofullerene for molecular location sensing
  Y. Takano; R. Tashita; M. Suzuki; H. Imahori; T. Akasaka
  56th The American Chemical Society meeting, Aug. 2018, English, Oral presentation
  [International presentation]
• Extended Diffusion of Charge Carriers in Perovskite Nanocrystal Assembly
  S. Ghimire; L. Chouhan; K. Yuyama; Y. Takano; V. P. Biju
  日本化学会第98春季年会, Mar. 2018, Japanese, Oral presentation
  [Domestic Conference]
• Photoinduced reductive reaction in mitochondria by electron donor/acceptor linked molecules
  Y. Takano; R. Munechika; V. P. Biju; H. Harashima; H. Imahori; Y. Yamada
  日本化学会第98春季年会, Mar. 2018, English, Oral presentation
  [Domestic Conference]
• Development of Electron Donor-Acceptor Conjugates for Utilizing Photoinduced Charge Separated State in Cell Environment
  Y. Takano; T. Numata; K. Fujishima; T. Murakami; M. Kengaku; S. Sakaki; Y. Mori; H. Imahori
  iCeMS International Symposium Hierarchical Dynamics in Soft Materials and Biological Matter, Sep. 2015, English, Poster presentation
  [International presentation]
• Porphyrin-Fullerene Based Donor-Acceptor Conjugates for Photocontrol of Cell Membrane Potentials
  Y. Takano; T. Numata; K. Fujishima; T. Murakami; M. Kengaku; Y. Mori; H. Imahori
  The 227th the Electrochemical Society (ECS) meeting, Chicago, U.S.A., 26 May 2015, English, Oral presentation
  24 May 2015 - 28 May 2015, [International presentation]
• Unprecedented Chemical Reactivities and Potential Utilities of Paramagnetic Endohedral Metallofullerenes
  Y. Takano; T. Akasaka
  The 227th the Electrochemical Society (ECS) meeting, Chicago, U.S.A., May 2015, English, Keynote oral presentation
  [Invited], [International presentation]
• Development of Porphyrin-Fullerene Based Amphiphilic Donor-Acceptor Conjugates for Photocontrol on Cell Membrane Potential
  Y. Takano; T. Numata; M. Kengaku; T. Murakami; Y. Mori; H. Imahori
  The 95st Annual Meeting of the Chemical Society of Japan, Chiba, Japan, 28 Mar. 2015, Japanese, Oral presentation
  26 Mar. 2015 - 29 Mar. 2015, [Domestic Conference]
• Development of Porphyrin-Fullerene Based Donor-Acceptor Conjugates for Utilizing Photoinduced Charge Separated State in Cell Environment
  Y. Takano; H. Imahori
  2nd symposium on Nanocarbon bio symposium, Tokyo, Japan, Feb. 2015, Japanese, Oral presentation
  [Domestic Conference]
• Development of Porphyrin-Fullerene Based Donor-Acceptor Conjugates for Utilizing Photoinduced Charge Separated State in Cell Environment
  Yuta Takano
  International SPIRITS Symposium “Creation of Bio-Inspired, Non-Biological Mesoscale Hybrid Materials”, Kyoto, Japan, Nov. 2014, English, Invited oral presentation
  [Invited], [International presentation]
• Regulation of cell membrane potential and ion transport by utilizing photo-induced charge separation in organic molecules
  Yuta Takano
  iCeMS International Symposium “Light Control in Cell Biology”, Kyoto, Japan, Jun. 2014, English, Invited oral presentation
  [Invited], [International presentation]
• Synthesis and Photophysical and Photoelectrochemical Properties of Diazaporphyrin-Fullerene Linked Dyad
  M. Yamamoto; Y. Takano; Y. Matano; K. Stranius; N. V. Tkachenko; H. Lemmetyinen; H. Imahori
  225th the Electrochemical Society (ECS) meeting, May 2014, English, Oral presentation
  [International presentation]
• Unique Molecular Properties of a Paramagnetic Endohedral Metallofullerene La@C82: Its Chemical Reactivities, and Electronic and Magnetic Properties
  Y. Takano; J. Veciana; D. M. Guldi; N. Martin; T. Akasaka
  The 225th the Electrochemical Society (ECS) meeting, Orlando, U.S.A., May 2014, English, Invited oral presentation
  [Invited], [International presentation]
• Photoinduced depolarization in membrane of PC12 by fullerene-porphyrin linked molecules
  Y. Takano; T. Numata; K. Miyake; T. Murakami; Y. Mori; H. Imahori
  The 36th annual meeting of the Molecular Biology Society of Japan, Kobe, Japan, Dec. 2013, Japanese, Poster presentation
  [Domestic Conference]
• Unprecedented Chemical, Electronic and Magnetic Properties of a Paramagnetic Endohedral Metallofullerene La@C82
  Y. Takano; J. Veciana; D. S. Guldi; N. Martin; T. Akasaka
  3th Symposium on Carbon Nanoforms, Madrid, Spain, Sep. 2013, English, Invited oral presentation
  [Invited], [International presentation]
• Intra-molecular electron accepting and donating systems based on endohedral metallofullerenes
  Y. Takano; M. A. Herranz; N. Martin; D. M. Guldi; S. Nagas; T. Akasaka
  The 15th International Symposium on Novel Aromatic Compounds (ISNA), Jul. 2013, English, Poster presentation
  [International presentation]
• Photoregulation of Mammalian Cell Membrane Potential by Porphyrin/Fullerene based Donor/Acceptor Linked Molecules
  Y. Takano; T. Numata; T. Murakami; F. Kawashima; N. Morone; J. E. Heuser; Y. Mori; H. Imahori
  The 15th International Symposium on Novel Aromatic Compounds (ISNA), Jul. 2013, English, Poster presentation
  [International presentation]
• Inhibition of potassium channels and control of cell membrane potentials by photo-induced charge separated molecules
  Y. Takano; T. Numata; T. Murakami; F, Kawashima; N. Morone; J. E. Heuser; Y. Mori; H. Imahori
  第93回日本化学会春季年会, Mar. 2013, Japanese, Oral presentation
  [Domestic Conference]
• Establishment of intra-molecular electron accepting and donating systems based on endohedral metallofullerenes
  Y. Takano; N. Mizorogi; M. A. Herranz; N. Martin; D. M. Guldi; S. Nagase; T. Akasaka
  第43回フラーレン•ナノチューブ・グラフェン総合シンポジウム, Miyagi, Japan, Sep. 2012, Japanese, Oral presentation
  [Domestic Conference]
• Establishment of intra-molecular electron accepting and donating systems based on endohedral metallofullerenes
  Y. Takano; S. Obuchi; N. Mizorogi; M. A. Herranz; N. Martin; S. Wolfrum; D. M. Guldi; S. Nagase; T. Akasaka
  10th International Conference on Heteroatom Chemistry (ICHAC), Kyoto, Japan, May 2012, English, Oral presentation
  [International presentation]
• Donor-Acceptor Conjugates of Lanthanum Endohedral Metallofullerene, La2@C80, and π-Extended Tetrathiafulvalene
  Y. Takano; M. A. Herranz; N, Martin; S. G. Radhakrishnan; D. M. Guldi; T. Tsuchiya; T. Akasaka
  PACIFICHEM 2010, Honolulu, U.S.A., Dec. 2010, English, Invited oral presentation
  [Invited], [International presentation]

• 環境物質科学基礎論Ⅱ, 2024年, 修士課程, 環境科学院

• フラーレン・ナノチューブ・グラフェン学会
• JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
• The American Chemical Society
• THE CHEMICAL SOCIETY OF JAPAN

• カーボンドットを応用した感染制御能と骨形成能を有する革新的GBR膜の開発
  科学研究費助成事業
  01 Apr. 2024 - 31 Mar. 2027
  横山 敦郎; 赤坂 司; 山本 悟; 平田 恵理; 高野 勇太
  日本学術振興会, 基盤研究(C), 北海道大学, 24K12996
• 酵素分解を利用した循環型メゾスコピック粒子材料
  戦略的な研究開発の推進 戦略的創造研究推進事業 さきがけ
  Sep. 2024 - Mar. 2027
  高野 勇太
  酵素分解を利用した革新的な微粒子生成法により、環境調和型メゾスコピックナノ粒子材料(ms粒子)を創製する手法の確立を目指します。特に、非可食性バイオマスや廃棄物由来の原料を用いて金属ナノ粒子集合体や分子触媒ナノ粒子などを開発し、新規なms粒子の機能発現を実現します。本手法で生成されるms粒子は酵素分解性の連結部位を有するため、使用後の分解・リサイクルが容易な環境調和型ナノ材料として期待できます。
  科学技術振興機構, 北海道大学, Principal investigator, JPMJPR24M5
• Development of a novel photodynamic therapy for peri-implantitis using nanocarbons and near-infrared light
  Grants-in-Aid for Scientific Research
  01 Apr. 2023 - 31 Mar. 2026
  平田 恵理; 横山 敦郎; 高野 勇太
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 23K09266
• Development of Phototherapeutic Drugs and Elucidation of Single Molecule Dynamics Using Highly Bright Stable Quantum Dots and Innovative 3D cell system
  Grants-in-Aid for Scientific Research
  01 Apr. 2021 - 31 Mar. 2025
  高野 勇太; 宮武 由甲子; 平田 恵理; 山田 勇磨; 繁富 香織
  本年度は、当初計画通り「(II):マイクロ組織内の分子動態解明を利用した高効果光がん治療薬の開発」および「(III):マイクロ組織を活用した光治療薬開発プロセスの一般化」を中心に研究遂行した。また、本研究の遂行から発明された新規ナノ粒子作成方法について「(I):3D培養系で高い浸透性・発光性・安定性をもつ機能化量子ドットの合成と培養組織内動態の解明」に関連して新規展開し、その理解の深化と基盤構築を並行して行った。
  (II)に関して、各種光増感剤の改良・新規開発を行った。我々がこれまでも用いているπ拡張型ポルフィリン分子(rTPA)を利用した系の開発に成功した【成果論文2報】。ここではrTPAについて包括的な開発を行い、その液中挙動及び光励起状態での光増感剤としての性能評価をおこない、用途に応じて至適なrTPA誘導体を選択する基盤を確立した。この知見をもとに、ナノ薬剤やナノカーボンとの複合化による光治療薬向け化合物開発が加速した。
  (III)に関して、歯科医療応用に向けた近赤外光治療向けの化合物開発を行った。カーボンナノホーンを担体としてrTPAと複合化することで、効果的な近赤外光増感作用を発現して殺菌効果を示す材料開発を達成した【成果論文1報】。
  新規展開の(I)について、量子ドット凝集体を利用することでより長時間露光や環境変化に対しても安定に発光をつづける発光ラベルが得られることを見出した（特願2023- 79183、論文準備中）。この知見は、長時間観察が必要になることの多い3次元培養細胞系において、有用な発光ラベル調製法となりため、これを利用した薬物輸送キャリアのプロトタイプ開発も行った。これらは、3次元細胞系を基軸にした展開を行っていた本研究ゆえに実現した物質開発といえる。
  以上のように、研究は申請書記載の当初計画案にそっておおむね順調に進行している。
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 23K21067
• Development of Phototherapeutic Drugs and Elucidation of Single Molecule Dynamics Using Highly Bright Stable Quantum Dots and Innovative 3D cell system
  Grants-in-Aid for Scientific Research
  01 Apr. 2021 - 31 Mar. 2025
  高野 勇太
  本年度は、当初計画通り「(I):3D培養系で高い浸透性・発光性・安定性をもつ機能化量子ドットの合成と培養組織内動態の解明（研究１～2年目計画）」のために細胞標的指向性分子-量子ドット複合体の開発に着手した。量子ドットに対してポリエチレングリコール鎖を介して水酸基（中性）およびカルボン酸（アニオン性）を接合した量子ドットを合成した。また、量子ドットに対して癌細胞マーカーとして良く知られているCD44抗体およびEpCAM抗体を接合した複合体も作成し、血液モデルのPBMC中から癌細胞を選択的に癌細胞認識できることを確認した。当該量子ドット-抗体複合体は現在、膵がん細胞における取り込み挙動を、2次元培養および3次元培養にて検討中である。また、量子ドット自体の光安定性についても検討を行い、光照射強度に応じて表面エッチングが起きる一方、光強度の制御や量子ドット表面組成によって細胞毒性を抑え得ることを見出した。
  また「(II):マイクロ組織内の分子動態解明を利用した高効果光がん治療薬の開発（研究２～３年目計画）」に関して、その前段階として光増感剤の開発検討を行った。我々がこれまでも研究に用いているπ拡張型ポルフィリン分子(rTPA)について、量子ドット表面への担持やナノカーボン表面への担持を行い、その光増感性能（＝一重項酸素発生能）の検証を行った。その結果、量子ドット表面への直接不可は、分子凝集などが原因となり十分な一重項酸素発生能を発揮しない一方、ナノカーボンの1種であるカーボンナノホーンに担持したrTPAは十分な一重項酸素発生能と殺がん効果を発揮し得ることを見出した。
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 21H01753
• Development of innovative artificial bone with drug release ability using photoresponsivity of carbon dots
  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)
  30 Jun. 2022 - 31 Mar. 2024
  横山 敦郎; 山本 悟; 平田 恵理; 高野 勇太
  Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Research (Exploratory), Hokkaido University, 22K19609
• Development of Trojan horse-type cancer therapeutics by elucidating and utilizing the predation mechanism of pancreatic cancer cells
  Grants-in-Aid for Scientific Research
  09 Jul. 2021 - 31 Mar. 2023
  高野 勇太; 宮武 由甲子; 山田 勇磨; 繁富 香織
  本年度は当初計画通り、「[段階-I] 捕食誘引物質の粗分離、観察、構造決定による同定」にとりかかり、膵がん細胞の死細胞を調製した上で捕食誘引物質の分離を開始した。まず、死細胞について大きく「アポトーシス様死細胞」と「ネクローシス様死細胞」に分けて調製し、それぞれ膵がん細胞より再構築したミクロ組織3次元と共培養しながらリアルタイム顕微鏡観察を行い、取り込まれる挙動の観察を行った。この際、コントロール条件として1μm（大体アポトーシス死細胞と同サイズ）のCOOH修飾蛍光ビーズを用いた。結果、COOH修飾蛍光ビーズでは細胞への取り込み、特に細胞集団が触手を伸ばすなどの能動的な取り込みは起きないことを確認した。そして「アポトーシス様死細胞」と「ネクローシス様死細胞」は両者とも取り込まれることを確認したが、ネクローシス様死細胞では取り込みがやや少ない傾向にあった。これはネクローシスでは死細胞構造がランダムであるとともに、細胞内容物が維持できないことが一因であると考えられた。よって、今後の検討は主にアポトーシス様死細胞で行うこととした。現在は、アポトーシス様死細胞の大量調製と、粗分離を開始したところである。
  また、「[段階-II]捕食誘引物質を複合化した高薬効性の光がん治療薬の合成開発」の準備段階として、量子ドットに近赤外光殺がん分子(rTPA)を接合した複合体や、ドラッグデリバリキャリアとrTPAの複合化も行い、その一重項酸素発生能および光殺がん効果を確認した。本研究の遂行によってドラッグデリバリキャリアとrTPAの相性により、内容分子の機能性（本研究の場合は光殺がん性能）が変化することが分かった。今後、最適化を進め最大効率で殺がん効果を示す複合体プロトタイプを作成し、本研究の目的とするトロイの木馬型殺がん化合物を完成させる。
  Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Research (Exploratory), Hokkaido University, 21K19036
• インプラント周囲炎治療を可能とする光応答性ナノカーボンインプラントの開発
  科学研究費助成事業 基盤研究(C)
  01 Apr. 2020 - 31 Mar. 2023
  平田 恵理; 横山 敦郎; 高野 勇太
  本研究の目的は，カーボンナノ物質の光線力学作用を用いて，近赤外光を照射した際に抗菌作用を発揮させ，インプラント周囲炎に応用することである．本年度は，さらに高い殺菌効果を得るため，光増感剤をカーボンナノホーン(CNHs)に修飾し，その効果を検証した．
  π拡張型ポルフィリン分子（rTPA）は700nm近傍の光を高い効率で吸収し，約50%の高い量子収率で一重項酸素を発生させる．このrTPAをアミノ化したCNHsとの間でアミド結合形成し，rTPA-CNHを得た．CNH-rTPAの熱重量分析を行ったところ，CNH-rTPA中のCNHとrTPAの割合がおよそ1:1であることが示唆された．CNH-rTPAの吸収スペクトルを測定したところ，可視光領域から近赤外光領域に渡るCNHの特徴的な吸収と，仕込み量の比率に比例した712nm近傍に特徴的なrTPAの吸収帯が観測された．次に，一重項酸素発生能を評価したところ，CNHs:rTPA=1:1のものが一番大きな一重項酸素産生能を示したため，以後の実験ではこの条件で作成したCNH-rTPAを用いた．また，rTPAはPBSなどの高いイオン濃度溶液中に単独で存在すると凝集形成し一重項酸素が抑制されるところ，CNHと複合化することで十分な一重項酸素発生能を保持することも明らかとなった．
  Streptococcus mutans，Aggregatibacter actinomycetemcomitanceの分散液にrTPA-CNHを添加して10分間730nmの光を照射したところ，どちらの菌も半分以上の菌数減少がみられた．また，細胞毒性を調べるために，線維芽細胞の培養実験を行った．細胞播種4時間後にCNH-rTPAを添加し，10分間光照射した結果，CNH-rTPA添加および光照射による細胞数の減少はみられなかった．
  日本学術振興会, 基盤研究(C), 北海道大学, 20K10025
• Development of intelligent carbon nanomaterials for innovative biomaterials for oral region
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
  01 Apr. 2019 - 31 Mar. 2022
  YOKOYAMA ATSURO
  In this study, application of carbon nanomaterials (CNMs) for drug carrier and controlling release of drug, surface modification of Ti with CNMs, and production of CNMs based membrane were done to develop the intelligent carbon nanomaterials (i-CNMs) with high function capable of controlling its expression. Antibiotics was loaded to CNMs. It was able to control the expression of its function by photoirradiation. Also, acceleration of bone formation was observed around Ti by surface modification of Ti with CNMs. CNMs based membrane showed excellent shielding property and maintaining the space for GBR membrane. These results suggested the invention of i-CNMs and its possibility of application for biomaterials.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 19H03839
• new therapeutic of podocytopathy using cell membrane stabilization on podocytes via glycosphingolipid GM3
  Grants-in-Aid for Scientific Research
  01 Apr. 2017 - 31 Mar. 2022
  Kawashima Nagako
  In this study, we found that i) the early stage of podocyte injury is accompanied by a decrease in glycosphingolipid GM3, ii) enhancement of GM3 expression via valproic acid has preventive and therapeutic effects on an appearance of proteinuria and glomerulosclerotic lesions, iii) it is effective in preventing F-actin bundle assembly collapse and normalizing nephrin phosphorylation function, iv) nephrin and GM3 behave with each other in cooperatively.
  This suggests that nephrin, which constitutes the slit membrane, may be regulated by glycolipids around the transmembrane region of nephrin, resulting in the maintenance of healthy podocytes and normal slit membrane functions. Indeed, the study suggested the possibility that GM3, a glycosphingolipid expressed in podocytes, may also be a potential target for proteinuria therapy.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Kitasato University, 17K09709
• Construction of the strategy on innovative tissue repair and bone regeneration using biological properties of carbon nano-materials
  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)
  29 Jun. 2018 - 31 Mar. 2021
  YOKOYAMA ATSURO
  In this study, to establish new strategy on tissue and bone regeneration with the biological characteristics of CNHs, titanium was coated with CNHs with using electrodeposition. CNH/Ti was implanted in rat bone. Inflammatory cytokines and gene expression of macrophages cultured on CNH/Ti and Ti were analyzed and also fluorescent immunostaining was carried out.
  CNH/Ti promoted bone formation in early stage.The amounts of TNFα and IL-6 on CNH / Ti were significantly lower than those on Ti, and there was no significant difference in IL-10.Gene Ontology analysis by microarray showed genes related to transcription, repair and replication of macrophage DNA in CNH / Ti were down-regulated compared to Ti. More macrophages with high intensity for CD206 was observed on CNH/T compared with Ti. Therefore, it was suggested that CNHs on the Ti surface regulate transcription, repair and replication of DNA of macrophage, and effect on M2 macrophage polarization.
  Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Research (Exploratory), Hokkaido University, 18K19627
• Development of optical control method of cell organelle function by photoindeuced charge separation molecule
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
  01 Apr. 2015 - 31 Mar. 2018
  Takano Yuta; IMAHORI Hiroshi; MURAKAMI Tatsuya; YAMADA Yuma
  In this study, novel functional molecules utilizing the photoinduced charge separation were developed for a fundamental technology to develope photocontrol methods of cellular activities. We investigated intracellular optical functionality mainly for amphipathic ferrocene-porphyrin-fullerene linked molecules and aryl-acridinium molecules.
  As research outcomes, we succeeded in photoinduced depolarization of the cell membrane by high charge separation efficiency due to development of molecules with enhanced cell membrane fluidity. In addition, we succeeded in mitochondria selective molecular transport in living cells by utilization of drug transport carriers or optimization of molecular structure. The molecules demonstrated successful method for triggering photooxidation/reduction reactions in cells by irradiation with light.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), 15K05563
• Quest for Fundamental Principles in Photoinduced Charge Separation and Their Application
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S)
  31 May 2013 - 31 Mar. 2018
  IMAHORI Hiroshi
  Our comprehensive researches revealed that the linker structures in the porphyrin-nanocarbon covalent composites have a large impact on their optical and photophysical properties. Specifically, moderate length-spacers between donor and acceptor were found to be essential to produce a long-lived charge-separated state efficiently. Fast decay of photoinduced charge-transfer states (i.e., exciplex state) to the ground state was observed in not only simple donor-acceptor linked systems, but also more complex dye-semiconducting electrode interface for dye-sensitized solar cells and donor-acceptor mixed interface for organic thin film solar cells. Integrated views and interpretation on the undesirable unique phenomena have been developed to give us a universal guideline on efficient photoinduced charge separation.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (S), Kyoto University, 25220801
• 自己組織化による光機能発現
  科学研究費助成事業 基盤研究(A)
  01 Apr. 2013 - 31 Mar. 2017
  今堀 博; 梅山 有和; 高野 勇太; 村上 達也
  本研究では自己組織化と光機能性分子/ナノ材料を組み合わせ、高効率エネルギー変換や新規生体機能を発現する次世代人工光合成を創成していくことを目指した。すなわち、ナノ領域での光機能性分子/ナノ材料、メゾ-マイクロ領域の自己組織化の鍵となる相互作用を理解し、制御することを目的とした。特に次のような学際的な手法により、特異な巨視的特性-機能を発現させることを行った。(1) 種々の分子/ナノ材料を階層的に自己組織化するための構造ー機能相関の学理を解明することを目指した。特にフラーレン・カーボンナノチューブ・グラフェンを半導体電極上に同時に自己組織化し、光電変換特性を発現することに成功した。 (2) ポルフィリン、共役ポリマー、フラーレン誘導体などの光機能性分子/ナノ材料を合理的に電極上に自己組織化させることで高効率太陽光エネルギー変換を実現することを目指した。特に 浸漬溶媒を変化することで酸化チタン上の色素分子の吸着状態を変化させ、結果として色素増感太陽電池性能を制御できることを見いだした。一方、有機薄膜太陽電池では共役ポリマーの主鎖構造にハロゲン原子を導入することでフラーレン誘導体との混合膜状態を変化させ、太陽電池特性を制御することに成功した。(3) 光電荷分離分子と生きた細胞を自己組織化を通じて融合することで細胞機能を光で制御することを行った。具体的には光電荷分離分子を生きた細胞膜に導入し光照射を行うと、細胞膜電位の脱分極が起こること、また光電荷分離寿命と脱分極の大きさに相関があることを見いだした。
  日本学術振興会, 基盤研究(A), 京都大学, 25248018
• Novel porphyrin sensitizer-water splitting catalyst hybrids for light-driven material conversion
  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
  01 Apr. 2013 - 31 Mar. 2015
  IMAHORI HIROSHI
  To establish methodology for light-driven water splitting, we have focused on the creation of highly efficient water splitting catalyst driven by light as well as the fabrication of the corresponding photoelectrochemical cell for material conversion. First, we synthesized a series of porphyrins with high oxidizing power for extracting multi-electron from the water splitting catalyst with water. Second, ruthenium complexes as the water splitting catalyst were prepared. Finally, they were assembled onto a semiconducting electrode, which was found to exhibit the capability of light-driven water splitting.
  Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Kyoto University, 25620148
• Photoinduced charge separation molecules for control on membrane protein functions
  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
  01 Apr. 2013 - 31 Mar. 2015
  TAKANO Yuta
  Cell membrane potential plays a crucial role in cellular functionｓ in various cells such as nerve cells. Therefore, artificial control on the membrane potential is promising technology for cellular engineering and medical applications. For the control, we have studied on organic molecules which can generate charge separated state by irradiation in cellular environment. As a fruit, we found a molecular system which display efficient charge separation (quantum yield = 41%). In a series of study revealed that the molecules can induce depolarization in membrane of PC12 and rat hippocampal neurons. In addition, the degrees parallel the charge separation efficiency.
  Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Kyoto University, 25810098

• The 15th Nanocarbon Bio Symposium
  23 Sep. 2025
  Planning etc
  Competition etc
  The Fullerenes, Nanotubes, Graphene (FNTG) Research Society