Researcher basic information

• 博士（理学）, 東京大学

• https://researchmap.jp/n_arai?lang=en

• https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201201082475184696
• https://orgsynth.eng.hokudai.ac.jp

• 201201082475184696

• Life Science, Bioorganic chemistry
• Nanotechnology/Materials, Structural organic chemistry and physical organic chemistry

• Bachelor's degree program, School of Engineering
• Master's degree program, Graduate School of Chemical Sciences and Engineering
• Doctoral (PhD) degree program, Graduate School of Chemical Sciences and Engineering

Research activity information

• Asymmetric Hydrogenation of α-Alkyl-Substituted β-Keto Esters and Amides through Dynamic Kinetic Resolution
  Taiga Yurino; Ryo Nishihara; Toshihisa Yasuda; Shuangli Yang; Noriyuki Utsumi; Takeaki Katayama; Noriyoshi Arai; Takeshi Ohkuma
  Organic Letters, American Chemical Society (ACS), 11 Jan. 2024
  Scientific journal
• Asymmetric Hydrogenation of α-Amino Esters into Optically Active β-Amino Alcohols through Dynamic Kinetic Resolution Catalyzed by Ruthenabicyclic Complexes
  Hiroki Ishikawa; Taiga Yurino; Ryo Komatsu; Ming-Yuan Gao; Noriyoshi Arai; Taichiro Touge; Kazuhiko Matsumura; Takeshi Ohkuma
  Organic Letters, American Chemical Society (ACS), 24 Mar. 2023
  Scientific journal
• Intramolecular [2 + 2] Cycloaddition of Isocarbostyrils Catalyzed by an Iridium Visible-Light Photocatalyst
  Noriyoshi Arai
  The Journal of Organic Chemistry, 88, 7, 4848, 4853, American Chemical Society (ACS), 09 Mar. 2023, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Formation of anti‐Bredt‐type azabicyclo[4.2.0]octene frameworks through photochemical intramolecular [2+2] cycloaddition between indole and a distal double bond of allene
  Noriyoshi Arai
  Journal of Heterocyclic Chemistry, 60, 2, 219, 231, Wiley, Feb. 2023, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal, Abstract
  
  Irradiation of 1‐(penta‐3,4‐dienoyl)indole derivatives in the presence of an aromatic ketone by a high‐pressure mercury lamp through Pyrex glass gave two types of cyclized products stereoselectively in high combined yields. The major product was a tetracyclic indoline derivative containing anti‐Bredt‐type azabicyclo[4.2.0]octene moiety produced via photo [2+2] cycloaddition between indole and a distal double bond of allene, accompanied by a small amount of proximal [2+2] adduct. Among a range of aromatic ketones screened, 3′,4′‐methylenedioxyacetophenone was found to sensitize the substrate most effectively.
• Stereospecific Skeletal Rearrangement of Epoxides Derived from Methylenecyclobutane-Fused N-Heterocycles
  Noriyoshi Arai
  HETEROCYCLES, 106, 7, 1198, 1198, CLOCKSS Archive, 2023, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Stereoselective construction of cycloheptene-fused indoline frameworks through photosensitised formal [5+2] cycloaddition
  Noriyoshi Arai; Takeshi Ohkuma
  Tetrahedron Letters, 88, 153588, 153588, Elsevier BV, Jan. 2022, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Asymmetric (Transfer) Hydrogenation of Functionalized Ketones
  Noriyoshi Arai; Takeshi Ohkuma
  Asymmetric Hydrogenation and Transfer Hydrogenation, 55, 85, Wiley, 26 Apr. 2021, [Peer-reviewed], [Invited]
  English, Scientific journal
• Photosensitized Intramolecular [2+2] Cycloaddition of 1H-Pyrrolo[2,3-b]pyridines Enabled by the Assistance of Lewis Acids
  Noriyoshi Arai; Takeshi Ohkuma
  The Journal of Organic Chemistry, 85, 23, 15717, 15725, Nov. 2020, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Isomerization‐Asymmetric Hydrogenation Sequence Converting Racemic β‐Ylidenecycloalkanols into Stereocontrolled β‐Substituted Cycloalkanols Using a Ru Catalytic System with Dual Roles
  Noriyoshi Arai; Yuki Okabe; Takeshi Ohkuma
  Advanced Synthesis & Catalysis, 361, 24, 5540, 5547, Wiley, 17 Dec. 2019, [Peer-reviewed], [Lead author]
  English, Scientific journal
• Stereoselective preparation of methylenecyclobutane-fused angular tetracyclic spiroindolines via photosensitized intramolecular [2+2] cycloaddition with allene
  Noriyoshi Arai; Takeshi Ohkuma
  Tetrahedron Letters, 60, 46, 151252, 151252, Elsevier BV, Nov. 2019, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Stereoselective Construction of Methylenecyclobutane-Fused Indolines through Photosensitized [2+2] Cycloaddition of Allene-Tethered Indole Derivatives
  Noriyoshi Arai; Takeshi Ohkuma
  Organic Letters, 21, 5, 1506, 1510, American Chemical Society (ACS), Mar. 2019, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Chemoselectivity Control in the Asymmetric Hydrogenation of γ- and δ-Keto Esters into Hydroxy Esters or Diols
  Noriyoshi Arai; Takanori Namba; Kei Kawaguchi; Yuki Matsumoto; Takeshi Ohkuma
  Angewandte Chemie - International Edition, 57, 5, 1386, 1389, Wiley-VCH Verlag, 26 Jan. 2018, [Peer-reviewed], [Lead author]
  English, Scientific journal
• Construction of Unique Heterocyclic Frameworks by Photochemical Reaction of 5- and 6-Membered Heteroaromatics
  Arai, Noriyoshi; Ohkuma, Takeshi
  Heterocycles, 96, 6, 997, 1035, 2018, [Peer-reviewed], [Invited], [Lead author, Corresponding author]
  English, Scientific journal
• Asymmetric Hydrogenation of Polysubstituted Aromatic Ketones Catalyzed by the DIPSkewphos​/PICA Derivative-​Ruthenium(II) Complexes
  Utsumi, Noriyuki; Arai, Noriyoshi; Kawaguchi, Kei; Katayama, Takeaki; Yasuda, Toshihisa; Murata, Kunihiko; Ohkuma, Takeshi
  ChemCatChem, 10, 18, 3955, 3959, 2018, [Peer-reviewed]
  English, Scientific journal
• Photochemically Promoted Aza-Diels Alder-Type Reaction: High Catalytic Activity of the Cr(III)/Bipyridine Complex Enhanced by Visible Light Irradiation
  Noriyoshi Arai; Takeshi Ohkuma
  JOURNAL OF ORGANIC CHEMISTRY, 82, 14, 7628, 7636, Jul. 2017, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Double Asymmetric Hydrogenation of Linear beta,beta-Disubstituted alpha,beta-Unsaturated Ketones into gamma-Substituted Secondary Alcohols using a Dual Catalytic System
  Noriyoshi Arai; Hironori Satoh; Ryo Komatsu; Takeshi Ohkuma
  CHEMISTRY-A EUROPEAN JOURNAL, 23, 37, 8806, 8809, Jul. 2017, [Peer-reviewed], [Lead author]
  English, Scientific journal
• Advancement in Catalytic Asymmetric Hydrogenation of Ketones and Imines, and Development of Asymmetric Isomerization of Allylic Alcohols
  Takeshi Ohkuma; Noriyoshi Arai
  CHEMICAL RECORD, 16, 6, 2801, 2819, Dec. 2016, [Peer-reviewed]
  English, Scientific journal
• Efficient chemoselective hydrogenation of organic azides catalyzed by palladium nanoparticles with alkyne-derived homogeneous supports
  Noriyoshi Arai; Nozomi Onodera; Takeshi Ohkuma
  TETRAHEDRON LETTERS, 57, 37, 4183, 4186, Sep. 2016, [Peer-reviewed], [Lead author]
  English, Scientific journal
• Development of Methods for Construction of Heterocyclic Frameworks by Photochemical Activation of Molecules
  Noriyoshi Arai; Takeshi Ohkuma
  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 74, 4, 360, 371, Apr. 2016, [Peer-reviewed], [Invited], [Lead author, Corresponding author]
  Japanese, Scientific journal
• Hydrogenation of nitroarenes with palladium nanoparticles stabilized by alkyne derivatives in homogeneous phase
  Noriyoshi Arai; Nozomi Onodera; Atsushi Dekita; Junichi Hori; Takeshi Ohkuma
  TETRAHEDRON LETTERS, 56, 25, 3913, 3915, Jun. 2015, [Peer-reviewed], [Lead author]
  English, Scientific journal
• NOVEL INTRAMOLECULAR CYCLIZATION-SKELETAL REORGANIZATION OF 2-ARYLTHIAZOLES UNDER PHOTOIRRADIATION
  Noriyoshi Arai; Moe Mizota; Takeshi Ohkuma
  HETEROCYCLES, 90, 1, 607, 616, Jan. 2015, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Stereoselective Preparation of Spiro[4.4] Cyclic Compounds by the Photochemical Activation of Oxazoles
  Noriyoshi Arai; Moe Mizota; Takeshi Ohkuma
  ORGANIC LETTERS, 17, 1, 86, 89, Jan. 2015, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Enantioselective Isomerization of Primary Allylic Alcohols into Chiral Aldehydes with the tol-binap/dbapen/Ruthenium(II) Catalyst
  Noriyoshi Arai; Keisuke Sato; Keita Azuma; Takeshi Ohkuma
  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52, 29, 7500, 7504, Jul. 2013, [Peer-reviewed], [Lead author]
  English, Scientific journal
• Asymmetric Hydrogenation of Alkynyl Ketones with the eta(6)-Arene/TsDPEN-Ruthenium(II) Catalyst
  Noriyoshi Arai; Hironori Satoh; Noriyuki Utsumi; Kunihiko Murata; Kunihiko Tsutsumi; Takeshi Ohkuma
  ORGANIC LETTERS, 15, 12, 3030, 3033, Jun. 2013, [Peer-reviewed], [Lead author]
  English, Scientific journal
• Asymmetric hydrogenation of quinoxalines, benzoxazines, and a benzothiazine catalyzed by chiral ruthenabicyclic complexes
  Noriyoshi Arai; Yu Saruwatari; Kotaro Isobe; Takeshi Ohkuma
  Advanced Synthesis and Catalysis, 355, 14-15, 2769, 2774, Wiley-VCH Verlag, 2013, [Peer-reviewed], [Lead author]
  English, Scientific journal
• 5.11 Reduction - Hydrogenation: C=O; Chemoselective
  T. Ohkuma; N. Arai
  Comprehensive Chirality, 5, 270, 300, Elsevier Ltd, Sep. 2012, [Peer-reviewed]
  English, In book
• Asymmetric Hydrogenation of N-Arylimines Catalyzed by the Xyl-Skewphos/DPEN-Ruthenium(II) Complex
  Noriyoshi Arai; Noriyuki Utsumi; Yuki Matsumoto; Kunihiko Murata; Kunihiko Tsutsumi; Takeshi Ohkuma
  ADVANCED SYNTHESIS & CATALYSIS, 354, 11-12, 2089, 2095, Aug. 2012, [Peer-reviewed], [Lead author]
  English, Scientific journal
• Design of molecular catalysts for achievement of high turnover number in homogeneous hydrogenation
  Noriyoshi Arai; Takeshi Ohkuma
  CHEMICAL RECORD, 12, 2, 284, 289, Apr. 2012, [Peer-reviewed], [Invited]
  English, Scientific journal
• Novel Intramolecular Photocyclization of alpha-Arylthiophene Derivatives
  Noriyoshi Arai; Koichiro Tanaka; Takeshi Ohkuma
  ORGANIC LETTERS, 14, 6, 1488, 1491, Mar. 2012, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Catalyst-Controlled Diastereoselection in the Hydrogenation of Heterocycloalkyl Ketones
  Masaya Akashi; Noriyoshi Arai; Tsutomu Inoue; Takeshi Ohkuma
  ADVANCED SYNTHESIS & CATALYSIS, 353, 11-12, 1955, 1960, Aug. 2011, [Peer-reviewed]
  English, Scientific journal
• Chiral Ruthenabicyclic Complexes: Precatalysts for Rapid, Enantioselective, and Wide-Scope Hydrogenation of Ketones
  Kazuhiko Matsumura; Noriyoshi Arai; Kiyoto Hori; Takao Saito; Noboru Sayo; Takeshi Ohkuma
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133, 28, 10696, 10699, Jul. 2011, [Peer-reviewed]
  English, Scientific journal
• Intramolecular iminium ene reaction with Cu(I) catalysts: facile formation of 4-amino-3-methylenechromans from O-propargyl salicylaldehydes and dialkylamines
  Noriyoshi Arai; Takeshi Ohkuma
  TETRAHEDRON, 67, 9, 1617, 1622, Mar. 2011, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Asymmetric Hydrogenation of Bicyclic Ketones Catalyzed by BINAP/IPHAN-Ru(II) Complex
  Noriyoshi Arai; Masaya Akashi; Satoshi Sugizaki; Hirohito Ooka; Tsutomu Inoue; Takeshi Ohkuma
  ORGANIC LETTERS, 12, 15, 3380, 3383, Aug. 2010, [Peer-reviewed], [Lead author]
  English, Scientific journal
• Photosensitized intramolecular cyclization of furan and non-activated alkene: pathway switching by the substituent on the furan ring
  Noriyoshi Arai; Koichiro Tanaka; Takeshi Ohkuma
  TETRAHEDRON LETTERS, 51, 9, 1273, 1275, Mar. 2010, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• ASYMMETRIC HYDROGENATION OF AROMATIC HETEROCYCLIC KETONES CATALYZED BY THE MsDPEN-Cp*Ir(III) COMPLEX
  Noriyuki Utsumi; Kunihiko Tsutsumi; Masahiko Watanabe; Kunihiko Murata; Noriyoshi Arai; Nobuhito Kurono; Takeshi Ohkume
  HETEROCYCLES, 80, 1, 141, 147, Jan. 2010, [Peer-reviewed]
  English, Scientific journal
• Highly Active and Selective Semihydrogenation of Alkynes with the Palladium Nanoparticles-Tetrabutylammonium Borohydride Catalyst System
  Junichi Hori; Kunihiko Murata; Toshiki Sugai; Hisanori Shinohara; Ryoji Noyori; Noriyoshi Arai; Nobuhito Kurono; Takeshi Ohkuma
  ADVANCED SYNTHESIS & CATALYSIS, 351, 18, 3143, 3149, Dec. 2009, [Peer-reviewed]
  English, Scientific journal
• Practical Asymmetric Hydrogenation of 3-Quinuclidinone Catalyzed by the XylSkewphos/PICA-Ruthenium(II) Complex
  Kunihiko Tsutsumi; Takeaki Katayama; Noriyuki Utsumi; Kunihiko Murata; Noriyoshi Arai; Nobuhito Kurono; Takeshi Ohkuma
  ORGANIC PROCESS RESEARCH & DEVELOPMENT, 13, 3, 625, 628, May 2009, [Peer-reviewed]
  English, Scientific journal
• Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by the TolBINAP/DMAPEN-Ruthenium(II) Complex: A Significant Effect of N-Substituents of Chiral 1,2-Diamine Ligands on Enantioselectivity
  Hirohito Ooka; Noriyoshi Arai; Keita Azuma; Nobuhito Kurono; Takeshi Ohkuma
  JOURNAL OF ORGANIC CHEMISTRY, 73, 22, 9084, 9093, Nov. 2008, [Peer-reviewed]
  English, Scientific journal
• Carbonyl Hydroboration
  Noriyoshi Arai; Takeshi Ohkuma
  Modern Reduction Methods, 159, 181, John Wiley and Sons, 04 Apr. 2008, [Peer-reviewed]
  English, In book
• Highly enantioselective hydrogenation of aryl vinyl ketones to allylic alcohols catalyzed by the tol-binap/dmapen ruthenium(II) complex
  Noriyoshi Arai; Keita Azuma; Noriyuki Nii; Takeshi Ohkuma
  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47, 39, 7457, 7460, 2008, [Peer-reviewed], [Lead author]
  English, Scientific journal
• Asymmetric hydrogenation of aromatic, aliphatic, and alpha,beta-unsaturated acyl silanes catalyzed by tol-binap/pica ruthenium(II) complexes: Practical synthesis of optically active alpha-hydroxysilanes
  Noriyoshi Arai; Ken Suzuki; Satoshi Sugizaki; Hiroko Sorimachi; Takeshi Ohkuma
  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47, 9, 1770, 1773, 2008, [Peer-reviewed]
  English, Scientific journal
• Asymmetric hydrogenation of alpha-hydroxy ketones catalyzed by MsDPEN-Cp*Ir(III) complex
  Takeshi Ohkuma; Noriyuki Utsumi; Masahito Watanabe; Kunihiko Tsutsumi; Noriyoshi Arai; Kunihiko Murata
  ORGANIC LETTERS, 9, 13, 2565, 2567, Jun. 2007, [Peer-reviewed]
  English, Scientific journal
• General asymmetric hydrogenation of alpha-branched aromatic ketones catalyzed by TolBINAP/DMAPEN-ruthenium(II) complex
  Noriyoshi Arai; Hirohito Ooka; Keita Azuma; Toshio Yabuuchi; Nobuhito Kurono; Tsutomu Inoue; Takeshi Ohkuma
  ORGANIC LETTERS, 9, 5, 939, 941, Mar. 2007, [Peer-reviewed]
  English, Scientific journal
• Asymmetric hydrogenation of alpha-chloro aromatic ketones catalyzed by eta(6)-arene/TsDPEN-ruthenium(II) complexes
  Takeshi Ohkuma; Kunihiko Tsutsumi; Noriyuki Utsumi; Noriyoshi Arai; Ryoji Noyori; Kunihiko Murata
  ORGANIC LETTERS, 9, 2, 255, 257, Jan. 2007, [Peer-reviewed]
  English, Scientific journal
• Generation of nitrile oxides from oxime derivatives by the oxidation with ammonium hexanitratocerate(IV)
  N Arai; M Iwakoshi; K Tanabe; K Narasaka
  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 72, 10, 2277, 2285, Oct. 1999, [Peer-reviewed]
  English, Scientific journal
• Generation of radical species from cyclohexane-1,2-dione and the reaction with olefins: Preparation of 4,5-dihydro-7(6H)-benzofuranone derivatives
  M Miura; N Arai; K Narasaka
  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 71, 6, 1437, 1441, Jun. 1998
  English, Scientific journal
• Oxidative generation of 1-nitroalkyl radicals and their addition reaction to olefins
  N Arai; K Narasaka
  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 70, 10, 2525, 2534, Oct. 1997
  English, Scientific journal
• Generation of alpha-alkylthio radicals by photoinduced one-electron oxidation of alpha-stannyl sulfides and their use for carbon-carbon bond formation
  T Ikeno; M Harada; N Arai; K Narasaka
  CHEMISTRY LETTERS, 2, 169, 170, 1997
  English, Scientific journal
• Development of new methods for generation of radical species by one-electron oxidation with metallic oxidants toward construction of carbon skeletons
  N Arai; K Narasaka
  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 54, 11, 964, 975, Nov. 1996, [Peer-reviewed]
  English, Scientific journal
• GENERATION OF ALPHA-NITROALKYL RADICALS BY OXIDATION OF NITRONATE ANIONS WITH CERIUM(IV) AMMONIUM-NITRATE AND THEIR ADDITION-REACTION TO ELECTRON-RICH OLEFINS
  N ARAI; K NARASAKA
  CHEMISTRY LETTERS, 11, 987, 988, Nov. 1995
  English, Scientific journal
• GENERATION OF ARYL RADICALS BY THE OXIDATION OF ALPHA-(ARYLAZO)TRIPHENYLMETHANES BY CERIUM(IV) AMMONIUM-NITRATE
  N ARAI; K NARASAKA
  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 68, 6, 1707, 1714, 1995, [Peer-reviewed]
  English, Scientific journal
• OXIDATIVE GENERATION OF THIOALKYL CATIONS FROM 2-TRIBUTYLSTANNYL-1,3-DITHIANES AND 1-(TRIBUTYLSTANNYL)ALKYL SULFIDES AND THEIR REACTIONS WITH OLEFINIC NUCLEOPHILES
  K NARASAKA; N ARAI; T OKAUCHI
  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 66, 10, 2995, 3003, Oct. 1993, [Peer-reviewed]
  English, Scientific journal
• GENERATION OF CATION RADICALS FROM 2-TRIBUTYLSTANNYL-1,3-DITHIANES AND THEIR REACTION WITH OLEFINS
  K NARASAKA; T OKAUCHI; N ARAI
  CHEMISTRY LETTERS, 7, 1229, 1232, Jul. 1992
  English, Scientific journal

• Investigation on the stereoselective construction of fused-ring frameworks by using photochemical properties of N-heteroaromatic compounds
  Noriyoshi Arai, Journal of Synthetic Organic Chemistry, Japan, 82, 3, 234, 246, Mar. 2024, [Peer-reviewed], [Lead author, Corresponding author]
  Japanese
• Asymmetric Hydrogenation of α-Amino Esters through Dynamic Kinetic Resolution Catalyzed by Ruthenabicyclic Complexes (RUCY)
  石川宏紀; 百合野大雅; 百合野大雅; 小松稜; GAO Ming-Yuan; 新井則義; 峠太一郎; 松村和彦; 大熊毅; 大熊毅, シンポジウム「モレキュラー・キラリティー」講演要旨集, 2023 (CD-ROM), 2023
• Development of Asymmetric Reactions Catalyzed by Ruthenium Complexes with Two Kinds of Ligands
  Takeshi Ohkuma; Nobuhito Kurono; Noriyoshi Arai, Bulletin of the Chemical Society of Japan, 92, 3, 475, 504, 2019, [Peer-reviewed]
  English, Introduction scientific journal
• 基礎講座：有機合成化学(2) あの身近な化合物はこうやって作られた
  新井則義; 大熊毅, 現代化学, 561, 18, 23, Dec. 2017, [Invited]
  東京化学同人, Japanese, Introduction other
• 基礎講座：有機合成化学(1) 有機化合物の作り方事始め
  新井則義; 大熊毅, 現代化学, 560, 17, 21, Nov. 2017, [Invited]
  Japanese, Introduction other
• Design of molecular catalysts for achievement of high turnover number in homogeneous hydrogenation
  Noriyoshi Arai; Takeshi Ohkuma, CHEMICAL RECORD, 12, 2, 284, 289, Apr. 2012, [Peer-reviewed]
  English, Introduction scientific journal
• 4 Studies toward the Total Synthesis of Kazusamycin, an Antitumor Compound
  Arai Noriyoshi; Chikaraishi Noriko; Omura Satoshi; Kuwajima Isao, Symposium on the Chemistry of Natural Products, symposium papers, 0, 44, 19, 24, 01 Sep. 2002
  Kazusamycin, which was isolated as a metabolite of actinomycete strain 81-484, attracts much attention due to its potent antitumor activity on P388 leukemia and sarcoma 180. It was also effective in completely preventing growth of HeLa cells at a concentration of 3.3ng/ml. On the other hand, from the structural point of view, only its planar structure was elucidated, and both its absolute configuration and complete relative configuration remain unknown. We are making an effort on the total synthesis of Kazusamycin in order to determine its absolute configuration and to establish a practical..., Symposium on the chemistry of natural products, Japanese
• スズヒドリドに代わる新規ラジカルメディエーター:シリルシクロヘキサジエン
  新井 則義, 化学と工業 = Chemistry and chemical industry, 54, 4, 492, 492, 01 Apr. 2001
  Japanese

• 有機合成実験法ハンドブック
  大熊毅; 新井則義, 25.1.4 還元法―水素ガスを用いる―触媒の調製と反応例
  丸善, 2015, [Joint work]
• e-EROS Encyclopedia of Reagents for Organic Synthesis
  Ohkuma, Takeshi; Arai, Noriyoshi, Phosphine, 1,1'-(1R)-[1,1'-binaphtharene]-2,2'-diylbis[bis(4-methylphenyl)-; Phosphine, 1,1'-(1S)-[1,1'-binaphtharene]-2,2'-diylbis[bis(4-methylphenyl)-
  Wiley Online Library, 2014, [Joint work]
• Comprehensive Chirality
  Ohkuma, Takeshi; Arai, Noriyoshi, Reduction–Hydrogenation: C=O; Chemoselective
  Elsevier, 2012, [Joint work]
• Science of Synthesis, Stereoselective Synthesis 2
  Arai, Noriyoshi; Ohkuma, Takeshi, Reduction of Carbonyl Groups: Hydrogenation
  Thieme, 2010, [Joint work]
• 触媒便覧
  大熊毅; 新井則義, 17.6.2不斉水素化反応
  講談社サイエンティフィク, 2008, [Joint work]
• Modern Reduction Methods
  Arai, Noriyoshi; Ohkuma, Takeshi, Carbonyl Hydroboration
  Wiley-VCH, 2008, [Joint work]

• Generation of Molecular Complexity by Photochemical Activation of 5-Membered Heteroaromatics
  Noriyoshi Arai
  18th Malaysian International Chemical Congress, 03 Nov. 2014, English, Invited oral presentation
  [Invited], [International presentation]
• Enantioselective 1,3-Hydrogen Migration of Primary Allylic Alcohols Catalyzed by Diphosphine–Ru(II) Complexes
  Arai, Noriyoshi; Sato, Keisuke; Ohkuma, Takeshi
  26th International Conference on Organometallic Chemistry, 14 Jul. 2014, English, Oral presentation
  [International presentation]

• 有機反応・構造論, 2024年, 修士課程, 総合化学院
• 有機化学Ⅱ, 2024年, 学士課程, 工学部
• 応用化学学生実験Ⅴ, 2024年, 学士課程, 工学部

• THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY
• THE CHEMICAL SOCIETY OF JAPAN

• 光による分子活性化を活用した高立体選択的有機分子構築手法の開発
  科学研究費助成事業，基盤研究C
  Apr. 2013 - Mar. 2015
  新井則義
  日本学術振興会, Principal investigator, Competitive research funding
• 高原子価金属化合物による酸化反応を利用した1、3−双極子発生手法の開発
  科学研究費助成事業
  1997 - 1998
  新井 則義
  筆者は,α-ヒドロキシイミノカルボン酸に対し,アルケン,またはアルキン類の存在下,硝酸アンモニウムセリウム(IV)(CAN)を作用させることによりニトリルオキシドを生成し,対応する付加生成物として4,5-ジヒドロイソオキサゾール,あるいはイソオキサゾール誘導体がそれぞれ得られることをすでに見出している。今年度の検討において,ニトリルオキシドの前駆体としてα-ヒドロキシイミノカルボン酸のみならず2-オキソアルドキシムも有効に活用でき,アシル(アロイル)ニトリルオキシドの発生に利用できることを見出した。たとえば,フェニルグリオキサール-1-オキシムに対しアクリル酸エチルの存在下CANを作用させると,生じたベンゾイルニトリルオキシドとアクリル酸エチルとの環状付加反応が進行し,3-ベンゾイル-4,5-ジヒドロイソオキサゾール-5-カルボン酸エチルが85%の収率で得られる。アシル(アロイル)ニトリルオキシドの効率の良い発生手法についてはわずかしか報告例がないが,本手法を用いることにより3-アシルイソオキサゾール誘導体を収率良く合成することができる。さらに,2-オキソアルドキシムに代え2-オキソアルデヒド-1-ヒドラゾンを用いれば,ニトリルオキシドと同様1,3-双極子の一種であるニトリルイミンを発生させることも可能なのではないかと考え,フェニルグリオキサール-1-アセチルヒドラゾンに対し,CANを作用させ反応を試みた。その結果,オレフィンとの付加生成物は得られなかったものの,自己環化生成物である1,3,4-オキサジアゾール誘導体が得られた。この化合物はニトリルイミンの発生を示唆するものと考えられる。
  日本学術振興会, 奨励研究(A), 東京大学, 09740462