Research activity information

• Effects of Water on the Sealing Ability and Biocompatibility of a Methacrylate Ester-based Adhesive Sealer
  Kai SUZUKI; Taro WASHIZU; Tsutomu SUGAYA
  The Japanese Journal of Conservative Dentistry, 69, 1, 21, 32, The Japanese Society of Conservative Dentistry, 28 Feb. 2026, [Peer-reviewed]
  Japanese, Purpose: Root canal sealers are essential for sealing complex anatomical structures such as lateral canals, fins, and isthmuses. Because these narrow spaces cannot be dried thoroughly with paper points, sealers must function effectively under various moisture conditions. Nevertheless, the effects of water contamination on the setting behavior, sealing performance, and biocompatibility of sealers have not been sufficiently clarified. MetaSeal Soft Paste (MSSP), a methacrylate ester-based and highly hydrophilic sealer composed mainly of 4-methacryloxyethyl trimellitate anhydride, 2-hydroxyethyl methacrylate, and water, may have beneficial properties in the presence of moisture. This study aimed to compare the effects of water incorporation and dentin surface moisture on the sealing ability and biocompatibility of MSSP with those of conventional resin- and zinc oxide-eugenol-based sealers.
  
   Methods: MSSP was mixed with distilled water at weight ratios of 1 : 0 and 1 : 1 to evaluate polymerization rate, and at ratios of 1 : 0 and 1 : 0.5 to assess its solubility. In addition, MSSP, AH Plus, and Canals N were mixed with water at ratios of 1 : 0, 1 : 0.1, 1 : 0.2, or 1 : 0.3, applied to dentin blocks, and subjected to dye penetration testing after setting. Each sealer without water incorporation was applied to water-moistened dentin surfaces to assess the effect of surface moisture on sealing performance. Finally, water-mixed sealers were implanted into rat subcutaneous connective tissue, and inflammatory responses were assessed histologically.
  
   Results: MSSP showed no change in the polymerization rate when mixed with water at a 1 : 1 ratio, nor in solubility when mixed at a 1 : 0.5 ratio. In dye penetration tests, water incorporation had a minimal effect on MSSP, whereas AH Plus and Canals N showed markedly higher leakage at a 1 : 0.2 water ratio than MSSP (p＜0.05). MSSP maintained low leakage regardless of moisture on the dentin surface, with significantly superior sealing ability compared with AH Plus and Canals N (p＜0.01). Moreover, MSSP induced only minimal inflammation even when implanted immediately after mixing with water, whereas AH Plus and Canals N elicited significantly stronger inflammatory reactions (p＜0.01).
  
   Conclusion: MSSP exhibited a stable polymerization rate and solubility as well as high sealing performance even under water contamination or moist dentin conditions, and maintained excellent biocompatibility despite water incorporation.
• 清掃状態が不良な歯周病に対するCPC製剤の洗口とスケーリングの併用による臨床効果
  竹生 寛恵; 工藤 愛; 下地 伸司; 小田島 朝臣; 加藤 昭人; 鷲巣 太郎; 町田 紗樹; 高橋 直紀; 田中 佐織; 菅谷 勉
  日本歯周病学会会誌, 67, 秋季特別, 149, 149, (NPO)日本歯周病学会, Oct. 2025
  Japanese
• 4-META/MMA-TBBレジンシーラーとレジン製ポイントを用いた根管充填による垂直歯根破折抵抗性
  鷲巣 太郎; 菅谷 勉
  接着歯学, 34, 1, 9, 15, (一社)日本接着歯学会, Apr. 2016, [Peer-reviewed], [Lead author]
  Japanese, Scientific journal
• クエン酸応用が3種の水酸化カルシウム製剤の除去と歯根象牙質の接着性に及ぼす影響
  木村 慎吾; 菅谷 勉; 鷲巣 太郎; 川浪 雅光
  北海道歯学雑誌, 35, 2, 112, 122, 北海道歯学会, Mar. 2015
  Japanese
• クエン酸応用が水酸化カルシウムの除去と根管封鎖性に及ぼす影響
  鷲巣 太郎; 菅谷 勉; 川浪 雅光
  北海道歯学雑誌, 33, 2, 82, 93, 北海道歯学会, Mar. 2013, [Peer-reviewed], [Lead author]
  Japanese, Doctoral thesis

• Effects of Water on the Sealing Ability and Biocompatibility of a Methacrylate Ester-based Adhesive Sealer
  Kai SUZUKI; Taro WASHIZU; Tsutomu SUGAYA, The Japanese Journal of Conservative Dentistry, 69, 1, 21, 32, 28 Feb. 2026
  Purpose: Root canal sealers are essential for sealing complex anatomical structures such as lateral canals, fins, and isthmuses. Because these narrow spaces cannot be dried thoroughly with paper points, sealers must function effectively under various moisture conditions. Nevertheless, the effects of water contamination on the setting behavior, sealing performance, and biocompatibility of sealers have not been sufficiently clarified. MetaSeal Soft Paste (MSSP), a methacrylate ester-based and highly hydrophilic sealer composed mainly of 4-methacryloxyethyl trimellitate anhydride, 2-hydroxyethyl methacrylate, and water, may have beneficial properties in the presence of moisture. This study aimed to compare the effects of water incorporation and dentin surface moisture on the sealing ability and biocompatibility of MSSP with those of conventional resin- and zinc oxide-eugenol-based sealers.
  
   Methods: MSSP was mixed with distilled water at weight ratios of 1 : 0 and 1 : 1 to evaluate polymerization rate, and at ratios of 1 : 0 and 1 : 0.5 to assess its solubility. In addition, MSSP, AH Plus, and Canals N were mixed with water at ratios of 1 : 0, 1 : 0.1, 1 : 0.2, or 1 : 0.3, applied to dentin blocks, and subjected to dye penetration testing after setting. Each sealer without water incorporation was applied to water-moistened dentin surfaces to assess the effect of surface moisture on sealing performance. Finally, water-mixed sealers were implanted into rat subcutaneous connective tissue, and inflammatory responses were assessed histologically.
  
   Results: MSSP showed no change in the polymerization rate when mixed with water at a 1 : 1 ratio, nor in solubility when mixed at a 1 : 0.5 ratio. In dye penetration tests, water incorporation had a minimal effect on MSSP, whereas AH Plus and Canals N showed markedly higher leakage at a 1 : 0.2 water ratio than MSSP (p＜0.05). MSSP maintained low leakage regardless of moisture on the dentin surface, with significantly superior sealing ability compared with AH Plus and Canals N (p＜0.01). Moreover, MSSP induced only minimal inflammation even when implanted immediately after mixing with water, whereas AH Plus and Canals N elicited significantly stronger inflammatory reactions (p＜0.01).
  
   Conclusion: MSSP exhibited a stable polymerization rate and solubility as well as high sealing performance even under water contamination or moist dentin conditions, and maintained excellent biocompatibility despite water incorporation., The Japanese Society of Conservative Dentistry, Japanese
• 接着性シーラーを用いた根管充填が垂直歯根破折の抵抗性に及ぼす効果
  河合 大史; 鷲巣 太郎; 菅谷 勉, 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集, 156回, 50, 50, May 2022
  (NPO)日本歯科保存学会, Japanese
• 機械的根管拡大形成の限界を超える高周波電流による歯内療法(Part2) ファイル未到達根管での発熱と放電を応用した根管治療
  菅谷 勉; 富永 敏彦; 鷲巣 太郎; 西田 絵利香; 熊谷 広道, The Quintessence, 40, 2, 0458, 0467, Feb. 2021
  クインテッセンス出版(株), Japanese
• 新規メタクリル酸エステル系接着性シーラーの硬化と封鎖性に及ぼす水の影響
  鈴木 魁; 鷲巣 太郎; 菅谷 勉, 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集, 151回, 120, 120, Oct. 2019
  (NPO)日本歯科保存学会, Japanese
• 塩化セチルピリジニウム配合含嗽剤を用いた歯周ポケットの超音波洗浄効果におよぼす口腔清掃の影響
  鷲巣 太郎; 菅谷 勉, 日本歯周病学会会誌, 60, 秋季特別, 133, 133, Oct. 2018
  (NPO)日本歯周病学会, Japanese
• プロービング時の出血があるSPT期の深い歯周ポケットに対する塩化セチルピリジニウム配合含嗽剤を用いた超音波洗浄の有効性
  鷲巣 太郎; 西尾 啓英; 島田 歩; 柳澤 剛; 小川 幸佑; 菅谷 勉, 日本歯周病学会会誌, 60, 春季特別, 133, 133, May 2018
  (NPO)日本歯周病学会, Japanese
• ホルモクレゾール貼薬後の洗浄が象牙質面への接着に及ぼす効果
  鷲巣 太郎; 菅谷 勉, 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集, 146回, 132, 132, May 2017
  (NPO)日本歯科保存学会, Japanese
• ホルモクレゾールがスーパーボンド根充シーラーと象牙質の接着強さに与える影響
  鷲巣 太郎; 菅谷 勉, 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集, 145回, 126, 126, Oct. 2016
  (NPO)日本歯科保存学会, Japanese
• スーパーボンド根充シーラーとPMMAポイントを用いた根管充填法による破折抵抗性
  鷲巣 太郎; 菅谷 勉; 川浪 雅光, 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集, 142回, 161, 161, Jun. 2015
  (NPO)日本歯科保存学会, Japanese
• 表面処理材の濃度の違いによる4-META/MMA-TBBレジンと骨との接着強さの比較検討
  工藤 愛; 鷲巣 太郎; 中谷 充宣; 菅谷 勉, 接着歯学, 32, 3, 185, 185, Nov. 2014
  (一社)日本接着歯学会, Japanese
• クエン酸応用が各種水酸化カルシウム製剤の除去と根管象牙質の接着性に及ぼす影響
  木村 慎吾; 菅谷 勉; 鷲巣 太郎; 川浪 雅光, 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集, 139回, 215, 215, Oct. 2013
  (NPO)日本歯科保存学会, Japanese
• クエン酸溶液による超音波根管洗浄が水酸化カルシウム除去と根管充填シーラーの接着に及ぼす影響
  鷲巣 太郎; 菅谷 勉; 川浪 雅光, 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集, 136回, 142, 142, May 2012
  (NPO)日本歯科保存学会, Japanese
• クエン酸応用が水酸化カルシウムの除去と根管封鎖性に及ぼす影響
  鷲巣 太郎, 北海道歯学雑誌, 32, 2, 246, 246, Mar. 2012
  北海道歯学会, Japanese
• FGF2/コラーゲンハイドロゲルの骨再生スキャフォールドへの応用
  宮治裕史; 小林尚子; 菅谷勉; 井原朝子; 鷲巣太郎; 横山裕之; 光銭裕太; 川浪雅光, 北海道外科雑誌, 55, 1, 85, 85, Jun. 2010
  北海道外科学会, Japanese
• FGF-2含有コラーゲンハイドロゲル-スポンジ複合体が骨新生に与える効果
  小林 尚子; 宮治 裕史; 井原 朝子; 鷲巣 太郎; 横山 裕之; 光銭 裕太; 菅谷 勉; 川浪 雅光, 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集, 131回, 51, 51, Oct. 2009
  (NPO)日本歯科保存学会, Japanese

• 歯周組織再建学研究Ⅱ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅰ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅱ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅲ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅴ, 2024年, 博士後期課程, 歯学院
• 歯周病学・歯内療法学臨床実習Ⅰ, 2024年, 学士課程, 歯学部
• 歯周病学・歯内療法学臨床実習Ⅱ, 2024年, 学士課程, 歯学部

• 日本顎咬合学会
• 日本接着歯学会
• 日本歯科保存学会

• A development of the bonding treatment of vertically fractured roots with cementum regeneration on 4-META/MMA-TBB resin
  Grants-in-Aid for Scientific Research
  2007 - 2009
  TANAKA Saori; SUGAYA Tsutomu; MIYAJI Hirofumi; KATO Akihito; YOSHIMURA Yoshitaka; IBE Yuko; TENKUMO Taichi; OTANI Kaori; NAKATSUKA Megumi; INOUE Kana; FUKUDA Hiroe; HENMI Masaru; KOSEN Yuta; TAMAGAWA Hiroki; HONMA Keishi; YOKOYAMA Hiroyuki; WASHIZU Taro; KANAYAMA Izumi; SUNOSAKI Maki; NAKAZAWA Atsushi
  To improve the bonding treatment of vertically fractured roots, we aimed to the newly cementum formation on a compound of resin and dentin powder, which may improve the binding between resin and cementum. In vitro, cytotoxicity and Micro Tensile Bond Strength (MTBS) test were assessed. It had little cytotoxicity and exhibited higher bond strength. In vivo, in some cases, we observed the newly cementum formation on a compound of resin and dentin powder. This experiment might exhibit a possibility of the newly cementum formation on a resin.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 19592191